title: Antibacterial structure-activity relationship studies of several tricyclic sulfur-containing flavonoids.
abstract: A structure-activity relationship study concerning the antibacterial properties of several halogen-substituted tricyclic sulfur-containing flavonoids has been performed. The compounds have been synthesized by cyclocondensation of the corresponding 3-dithiocarbamic flavanones under acidic conditions. The influence of different halogen substituents on the antibacterial properties has been tested against Staphylococcus aureus and Escherichia coli. Amongst the N,N-dialkylamino-substituted flavonoids, those having an N,N-diethylamino moiety exhibited good to excellent antimicrobial properties against both pathogens. Fluorine-substituted flavonoids were found to be less active than those bearing other halogen atoms.
authors.affiliation: Department of Chemistry, "Al. I. Cuza" University of Iasi, 11 Carol I Blvd., RO-700506 Iasi, Romania; Institute of Organic Chemistry, Technical University of Braunschweig, Hagenring 30, D-38106 Braunschweig, Germany.
authors.forename: Lucian G
authors.initials: LG
authors.lastname: Bahrin
authors.affiliation: Institute of Organic Chemistry, Technical University of Braunschweig, Hagenring 30, D-38106 Braunschweig, Germany.
authors.forename: Henning
authors.initials: H
authors.lastname: Hopf
authors.affiliation: Institute of Inorganic and Analytical Chemistry, Technical University of Braunschweig, Hagenring 30, D-38106 Braunschweig, Germany.
authors.forename: Peter G
authors.initials: PG
authors.lastname: Jones
authors.affiliation: Department of Chemistry, "Al. I. Cuza" University of Iasi, 11 Carol I Blvd., RO-700506 Iasi, Romania.
authors.forename: Laura G
authors.initials: LG
authors.lastname: Sarbu
authors.affiliation: Department of Biology, Al. I. Cuza University of Iasi, 11 Carol I, 700506-Iasi, Romania.
authors.forename: Cornelia
authors.initials: C
authors.lastname: Babii
authors.affiliation: Department of Biology, Al. I. Cuza University of Iasi, 11 Carol I, 700506-Iasi, Romania.
authors.forename: Alina C
authors.initials: AC
authors.lastname: Mihai
authors.affiliation: Department of Biology, Al. I. Cuza University of Iasi, 11 Carol I, 700506-Iasi, Romania.
authors.forename: Marius
authors.initials: M
authors.lastname: Stefan
authors.affiliation: Department of Chemistry, "Al. I. Cuza" University of Iasi, 11 Carol I Blvd., RO-700506 Iasi, Romania; Institute of Organic Chemistry, Technical University of Braunschweig, Hagenring 30, D-38106 Braunschweig, Germany.
authors.forename: Lucian M
authors.initials: LM
authors.lastname: Birsa
keywords: SAR studies; antibacterial activity; dithiocarbamates; dithiolium salts; flavonoids