title: Human metapneumovirus in patients hospitalized with acute respiratory infections: A meta-analysis.
abstract: This meta-analysis aimed to estimate the prevalence of human metapneumovirus (hMPV) infections in patients hospitalized for acute respiratory infection (ARI) and to study factors associated with this prevalence. Medline and ScienceDirect databases were searched for prospective observational studies that screened hospitalized patients with ARI for hMPV by RT-PCR, with data available at December 27, 2014. The risk of bias was assessed regarding participation rate, definition of ARI, description of diagnostic technique, method of inclusion identical for all subjects, standardized and identical sampling method for all subjects, analysis performed according to the relevant subgroups, and presentation of data sources. Random-effect meta-analysis with arcsine transformation and meta-regressions was used. In the 75 articles included, the prevalence of hMPV among hospitalized ARI was 6.24% (95% CI 5.25-7.30). An effect of the duration of the inclusion period was observed (p=0.0114), with a higher prevalence of hMPV in studies conducted during periods of 7-11 months (10.56%, 95% CI 5.97-16.27) or complete years (7.55%, 95% CI 5.90-9.38) than in periods of 6 months or less (5.36%, 95% CI 4.29-6.54). A significant increase in the incidence with increasing distance from the equator was observed (p=0.0384). hMPV should be taken into account as a possible etiology in hospitalized ARI.
authors.affiliation: Epidemiology and infection control unit, Dijon University Hospital, France. Electronic address: alefebvre@chu-reims.fr.
authors.forename: Annick
authors.initials: A
authors.lastname: Lefebvre
authors.affiliation: Virology Laboratory, Dijon University Hospital, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Manoha
authors.affiliation: Virology Laboratory, Dijon University Hospital, France.
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Bour
authors.affiliation: Epidemiology and infection control unit, Dijon University Hospital, France.
authors.forename: Rachid
authors.initials: R
authors.lastname: Abbas
authors.affiliation: Epidemiology and infection control unit, Dijon University Hospital, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Fournel
authors.affiliation: Epidemiology and infection control unit, Dijon University Hospital, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Tiv
authors.affiliation: Virology Laboratory, Dijon University Hospital, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Pothier
authors.affiliation: Epidemiology and infection control unit, Dijon University Hospital, France.
authors.forename: Karine
authors.initials: K
authors.lastname: Astruc
authors.affiliation: Epidemiology and infection control unit, Dijon University Hospital, France.
authors.forename: Ludwig Serge
authors.initials: LS
authors.lastname: Aho-Glélé
mesh_terms: D006760:Hospitalization; D006801:Humans; D029121:Metapneumovirus; D018184:Paramyxoviridae Infections
keywords: Acute respiratory infection; Human metapneumovirus; Meta-analysis; Prevalence; Respiratory virus