title: A Chiral Phosphoramidite Reagent for the Synthesis of Inositol Phosphates.
abstract: There is a paucity of chiral phosphoramidite reagents or chiral catalysis methods for the synthesis of biologically relevant inositol phosphates. A new C2-symmetrical chiral phosphoramidite has been developed and successfully applied to the synthesis of a set of chiral inositol bisphosphates. The reagent allowed bis-phosphorylation and chiral resolution, resulting in a concise synthetic route, thus expanding the toolbox available for the preparation of biologically relevant inositol phosphates in high optical purity.
authors.affiliation: Department of Chemistry and Applied Biosciences, ETH-Zürich , 8093 Zürich, Switzerland.
authors.forename: Estelle
authors.initials: E
authors.lastname: Durantie
authors.affiliation: Department of Chemistry and Applied Biosciences, ETH-Zürich , 8093 Zürich, Switzerland.
authors.forename: Samuel
authors.initials: S
authors.lastname: Huwiler
authors.affiliation: Department of Chemistry and Applied Biosciences, ETH-Zürich , 8093 Zürich, Switzerland.
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Leroux
authors.affiliation: Department of Chemistry and Applied Biosciences, ETH-Zürich , 8093 Zürich, Switzerland.
authors.forename: Bastien
authors.initials: B
authors.lastname: Castagner