title: Maternal age and intracytoplasmic sperm injection outcome in infertile couples at Khartoum, Sudan.
abstract: Background Intracytoplasmic sperm injection (ICSI) was considered as the mainstay of treatment for male infertility. Nowadays, the scope of ICSI has been widened to include other causes of infertility. There are few published data on ICSI in countries with low incomes. Aims A cross-sectional study was conducted at Saad AbuAlla and Banoun Centers, Khartoum, Sudan to investigate outcomes of ICSI and to determine the parameters that might predict pregnancy success rate following ICSI. Methods The study included 191 infertile couples who underwent 296 ICSI cycles between 1st April 2013 and 31 March 2014. Results One hundred and ninety one couples (comprising 296 cycles of ICSI) were enrolled to the study. The mean (SD) number of retrieved oocytes was 9.7 (7.5).  The mean (SD) number of transferred embryos was 2.9 (1.0). Out of these, 50 (26.2%) and 40 (20.9%) had chemical and clinical pregnancy, respectively. Thirty-six couples (18.8%) and five couples (2.6%) had miscarriage and had ectopic pregnancy, respectively. Under logistic regression, younger age (OR = 0.8, 95% CI= 0.81 ─ 0.96, P = 0.004) and endometrial thickness (OR = 1.3, 95% CI= 1.07─1.60, P = 0.009) were the significant predictors for the success of ICSI in inducing pregnancy. Conclusion                 The rates of successful fertilisation and pregnancy-to-term rates in this setting depend mainly on the maternal age.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, University of Khartoum, Khartoum, 11111, Sudan.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Ahmed
authors.affiliation: Adam and Hawa Fertility Center, Khartoum, 11111, Sudan.
authors.forename: Osama
authors.initials: O
authors.lastname: Shareef
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, University of Khartoum, Khartoum, 11111, Sudan.
authors.forename: Ishag
authors.initials: I
authors.lastname: Adam
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, University of Khartoum, Khartoum, 11111, Sudan.
authors.forename: Duria
authors.initials: D
authors.lastname: Rayis
keywords: ICSI; Sudan; age; infertility; intracytoplasmic sperm injection