title: A Sustainable, Semi-Continuous Flow Synthesis of Hydantoins.
abstract: Hydantoins are an important class of heterocycles with applications in pharmacy, agriculture, and as intermediates in organic synthesis. Traditional synthetic procedures to access hydantoins are target oriented with multiple synthetic steps and often use reagents that are not commercially available or sustainable. Herein, an efficient process is described for accessing hydantoins starting from commercially available amines using consecutive gas-liquid transformations (oxygen, carbon dioxide). This semi-continuous process produced ten benzylic/aliphatic hydantoins in good overall yields (52-84 %).
authors.affiliation: Department of Biology, Chemistry and Pharmacy, Free University Berlin, Takustrasse 3, 14195, Berlin, Germany.
authors.forename: Stella
authors.initials: S
authors.lastname: Vukelić
authors.affiliation: Department of Biology, Chemistry and Pharmacy, Free University Berlin, Takustrasse 3, 14195, Berlin, Germany.
authors.forename: Beate
authors.initials: B
authors.lastname: Koksch
authors.affiliation: Department of Biology, Chemistry and Pharmacy, Free University Berlin, Takustrasse 3, 14195, Berlin, Germany.|Biomolecular Systems, Max Planck Institute for Colloids and Interfaces, Am Mühlenberg, 14476, Potsdam, Germany.
authors.forename: Peter H
authors.initials: PH
authors.lastname: Seeberger
authors.affiliation: Biomolecular Systems, Max Planck Institute for Colloids and Interfaces, Am Mühlenberg, 14476, Potsdam, Germany. kerry.gilmore@mpikg.mpg.de.
authors.forename: Kerry
authors.identifier: http://orcid.org/0000-0001-9897-6017
authors.initials: K
authors.lastname: Gilmore
keywords: carbon dioxide; flow chemistry; hydantoins; multiphase chemistry; sustainable chemistry