title: [Desensitizing effect of stannous fluoride-containing toothpaste for patients with dentine hypersensitivity: a Meta-analysis].
abstract: OBJECTIVE
  This study aims to assess the effects of desensitizing toothpaste containing stannous fluoride on dentine hypersensitivity by performing Meta-analysis of randomized controlled trials (RCT) involving the treatment of dentine hypersensitivity with stannous fluoride-containing toothpaste.
  
  
  METHODS
  The study was developed based on the Cochrane handbook for systematic reviews of interventions (Version 5.1.0) and included the following: search strategy, selection criteria, data extraction, and risk of bias assessment. We searched electronic databases such as CNKI, CBM, PubMed, Embase, and Cochrane Library up to January 2015. RCT of treating dentine hypersensitivity with stannous fluoride-containing toothpaste were included. Data extraction and domain-based risk of bias assessment were independently performed by two reviewers. Meta-analysis was performed with RevMan 5.3 software.
  
  
  RESULTS
  Six RCT with 494 patients (247 in the experimental group and 247 in the control group) were included. The results of Meta-analysis showed that the desensitizing effect of stannous fluoride-containing toothpaste was significantly better than that of control in tactile sensitivity test (SMD=1.41, 95% confidence interval 0.74-2.09, P<0.00001) and air blast test (SMD = -1.16, 95% confidence interval -1.84--0.48, P<0.000 01).
  
  
  CONCLUSIONS
  Current evidence shows that stannous fluoride-containing toothpaste is effective in treating dentine hypersensitivity in clinic. However, due to limited sample size and lower quality of the included studies, more high quality and large-sample RCT are needed to further verify the evidence.
authors.forename: Shuliang
authors.initials: S
authors.lastname: Yang
authors.forename: Kai
authors.initials: K
authors.lastname: Ying
authors.forename: Fan
authors.initials: F
authors.lastname: Wang
authors.forename: Kangying
authors.initials: K
authors.lastname: Chen
authors.forename: Longbin
authors.initials: L
authors.lastname: Zhou
authors.forename: Qingfu
authors.initials: Q
authors.lastname: Yang
mesh_terms: D057133:Dentin Desensitizing Agents / Q000627:therapeutic use*; D003807:Dentin Sensitivity / Q000188:drug therapy*; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D012969:Sodium Fluoride; D014002:Tin Fluorides / Q000627:therapeutic use*; D014100:Toothpastes / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D057133:Dentin Desensitizing Agents; D014002:Tin Fluorides; D014100:Toothpastes; D012969:Sodium Fluoride