title: Activation of protein phosphatase 2A is responsible for increased content and inactivation of respiratory chain complex i induced by all-trans retinoic acid in human keratinocytes.
abstract: This study presents the effect of all-trans retinoic acid (ATRA) on cell growth and respiratory chain complex I in human keratinocyte cultures. Keratinocyte treatment results in increased level of GRIM-19 and other subunits of complex I, in particular of their carbonylated forms, associated with inhibition of its enzymatic activity. The results show that in keratinocytes ATRA-promoted phosphatase activity controls the proteostasis and activity of complex I.
authors.affiliation: Department of Basic Medical Sciences, Neurosciences and Sense Organs. University of Bari Aldo Moro, Bari, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Papa
authors.affiliation: Department of Basic Medical Sciences, Neurosciences and Sense Organs. University of Bari Aldo Moro, Bari, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Sardaro
authors.affiliation: Institute of Bioenergetics and Biomembranes (IBBE) of the Italian National Council of Researches (CNR), Bari, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Lippolis
authors.affiliation: Department of Basic Medical Sciences, Neurosciences and Sense Organs. University of Bari Aldo Moro, Bari, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Panelli
authors.affiliation: Department of Basic Medical Sciences, Neurosciences and Sense Organs. University of Bari Aldo Moro, Bari, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Scacco
mesh_terms: D051017:Apoptosis Regulatory Proteins / Q000032:analysis; D002478:Cells, Cultured; D042967:Electron Transport Complex I / Q000032:analysis / Q000187:drug effects*; D006801:Humans; D015603:Keratinocytes / Q000187:drug effects* / Q000378:metabolism; D009247:NADH, NADPH Oxidoreductases / Q000032:analysis; D054648:Protein Phosphatase 2 / Q000502:physiology*; D014212:Tretinoin / Q000494:pharmacology*
chemical_list: D051017:Apoptosis Regulatory Proteins; D014212:Tretinoin; D009247:NADH, NADPH Oxidoreductases; C439057:NDUFA13 protein, human; D054648:Protein Phosphatase 2; D042967:Electron Transport Complex I