title: The assessment of the effect of a cosmetic product brightening the skin of people with discolorations of different etiology.
abstract: BACKGROUND
  Hyperpigmentations are disorders displayed with a change in the color of the skin, its strange shape, the lack of symmetry, and irregular placement. They appear no matter on the age, gender, and often as a congenital defect. Disorder connected with overproduction of melanin by pigmentary cells. The change of color is due to endogenous and exogenous cause.
  
  
  OBJECTIVE
  The aim of this thesis was to conduct a research in vivo. This will allow to judge the effectiveness of the cosmetic product which brightens the skin with hyperpigmentation problems. The characteristics of dermocosmetics were tested on people with various etiology of hyperpigmentation. The aim of the research was to assess the effect of the active substances used daily on skin hyperpigmentation.
  
  
  METHODS
  The tests were carried out on groups of patients with hyperpigmentations. The application of the pharmaceutical and the use of specific apparatus measurements were taken on every medical checkup. A survey was conducted to assess the changes in the face, neck, and neckline skin. The research was based on the apparatus analysis of the skin condition (MPA®, VISIA®).
  
  
  RESULTS
  Regular application of the pharmaceutical caused brightening of hyperpigmentations (P < 0.05). General improvement in skin condition was also observed - the increase in skin elasticity, smoothness, and the enhancement of hydration levels.
  
  
  CONCLUSIONS
  Dermocosmetics for people with hyperpigmentation are an essential part of their medical treatment. In case of epidermal hyperpigmentation, the recipe of individually chosen and tested combination of ingredients enables us to reach satisfactory results.
authors.affiliation: Department of Cosmetic Raw Materials Chemistry, Faculty of Pharmacy, Medical University of Lodz, Lodz, Poland.
authors.forename: Malwina
authors.initials: M
authors.lastname: Zasada
authors.affiliation: Dr Irena Eris Cosmetic Laboratories, Dr Irena Eris Centre for Science and Research, Warsaw, Poland.
authors.forename: Renata
authors.initials: R
authors.lastname: Debowska
authors.affiliation: Dr Irena Eris Cosmetic Laboratories, Dr Irena Eris Centre for Science and Research, Warsaw, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Pasikowska
authors.affiliation: Department of Cosmetic Raw Materials Chemistry, Faculty of Pharmacy, Medical University of Lodz, Lodz, Poland.
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Budzisz
mesh_terms: D040761:Biomimetic Materials / Q000627:therapeutic use; D001834:Body Water / Q000378:metabolism; D004548:Elasticity / Q000187:drug effects; D005260:Female; D006801:Humans; D017495:Hyperpigmentation / Q000188:drug therapy* / Q000209:etiology; D008875:Middle Aged; D009525:Niacin / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D031804:Rumex; D012867:Skin / Q000378:metabolism; D063465:Skin Cream / Q000737:chemistry / Q000627:therapeutic use*; D062327:Skin Lightening Preparations / Q000737:chemistry / Q000627:therapeutic use*; D012879:Skin Physiological Phenomena / Q000187:drug effects; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D000521:alpha-MSH / Q000037:antagonists & inhibitors
chemical_list: D010936:Plant Extracts; D062327:Skin Lightening Preparations; D009525:Niacin; D000521:alpha-MSH
keywords: cosmetic formulation; hyperpigmentation; melanin; niacinamide; pigmentation