title: LILRA6 copy number variation correlates with susceptibility to atopic dermatitis.
abstract: Leukocyte immunoglobulin-like receptors (LILR) are expressed mostly on myelomonocytic cells where they are mediators of immunological tolerance. Two LILR genes, LILRA3 and LILRA6, exhibit marked copy number variation. We assessed the contribution of these genes to atopic dermatitis (AD) by analysing transmission in 378 AD families. The data indicated that copies of LILRA6 were over-transmitted to affected patients. They are consistent with a contribution of LILR genes to AD. They could affect the equilibrium between activating and inhibitory signals in the immune response.
authors.affiliation: Immunology Division, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK.
authors.forename: M R
authors.initials: MR
authors.lastname: López-Álvarez
authors.affiliation: Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, Wellcome Trust/MRC Building, Hills Road, Cambridge, CB2 0XY, UK.
authors.forename: W
authors.initials: W
authors.lastname: Jiang
authors.affiliation: Immunology Division, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK.
authors.forename: D C
authors.initials: DC
authors.lastname: Jones
authors.affiliation: Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, Wellcome Trust/MRC Building, Hills Road, Cambridge, CB2 0XY, UK.
authors.forename: J
authors.initials: J
authors.lastname: Jayaraman
authors.affiliation: Immunology Division, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK.|Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, Wellcome Trust/MRC Building, Hills Road, Cambridge, CB2 0XY, UK.|Molecular Genetics and Genomics Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London, SW3 6LY, UK.
authors.forename: C
authors.initials: C
authors.lastname: Johnson
authors.affiliation: Molecular Genetics and Genomics Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London, SW3 6LY, UK.
authors.forename: W O
authors.initials: WO
authors.lastname: Cookson
authors.affiliation: Molecular Genetics and Genomics Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London, SW3 6LY, UK.
authors.forename: M F
authors.initials: MF
authors.lastname: Moffatt
authors.affiliation: Immunology Division, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK.|Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, Wellcome Trust/MRC Building, Hills Road, Cambridge, CB2 0XY, UK.
authors.forename: J
authors.initials: J
authors.lastname: Trowsdale
authors.affiliation: Immunology Division, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK. jat51@cam.ac.uk.|Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, Wellcome Trust/MRC Building, Hills Road, Cambridge, CB2 0XY, UK. jat51@cam.ac.uk.
authors.forename: J A
authors.initials: JA
authors.lastname: Traherne
mesh_terms: D002648:Child; D004247:DNA / Q000032:analysis / Q000235:genetics*; D056915:DNA Copy Number Variations / Q000235:genetics*; D003876:Dermatitis, Atopic / Q000235:genetics* / Q000473:pathology*; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011971:Receptors, Immunologic / Q000235:genetics*
chemical_list: C586909:LILRA6 protein, human; D011971:Receptors, Immunologic; D004247:DNA
keywords: AD; Atopic dermatitis; CNV; LILR