title: Cold-stored cadaveric venous allograft for superior mesenteric/portal vein reconstruction during pancreatic surgery.
abstract: SMV/PV resection has become common practice in pancreatic surgery. The aim of this study was to evaluate the technical feasibility and surgical outcome of using cold-stored cadaveric venous allografts (AG) for superior mesenteric vein (SMV) and portal vein (PV) reconstruction during pancreatectomy.
  
  
  
  Patients who underwent pancreatic resection with concomitant vascular resection and reconstruction with AG between January 2006 and December 2014 were identified from our institutional prospective database. Medical records and pre- and postoperative CT-images were reviewed.
  
  
  
  Forty-five patients underwent SMV/PV reconstruction with AG interposition (n = 37) or AG patch (n = 8). The median operative time and blood loss were 488 min (IQR: 450-551) and 900 ml (IQR: 600-2000), respectively. Major morbidity (Clavien ≥ III) occurred in 16 patients. Four patients were reoperated (thrombosis n = 2, graft kinking/low flow n = 2) and in-hospital mortality occurred in two patients. On last available CT scan, 3 patients had thrombosis, all of whom also had local recurrence. Estimated cumulative patency rate (reduction in SMV/PV luminal diameter <70% and no thrombosis) at 12 months was 52%.
  
  
  
  Cold-stored cadaveric venous AG for SMV/PV reconstruction during pancreatic surgery is safe and associated with acceptable long-term patency.
authors.affiliation: Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Electronic address: dyrkle@ous-hf.no.
authors.forename: Dyre
authors.initials: D
authors.lastname: Kleive
authors.affiliation: Department of Radiology, Oslo University Hospital, Oslo, Norway.
authors.forename: Audun E
authors.initials: AE
authors.lastname: Berstad
authors.affiliation: Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Pathology, Oslo University Hospital, Oslo, Norway.
authors.forename: Caroline S
authors.initials: CS
authors.lastname: Verbeke
authors.affiliation: Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway; Department of Surgery, Drammen Hospital, Vestre Viken Hospital Trust, Drammen, Norway.
authors.forename: Sven P
authors.initials: SP
authors.lastname: Haugvik
authors.affiliation: Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
authors.forename: Ivar P
authors.initials: IP
authors.lastname: Gladhaug
authors.affiliation: Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Transplantation Medicine, Oslo University Hospital, Oslo, Norway.
authors.forename: Pål-Dag
authors.initials: PD
authors.lastname: Line
authors.affiliation: Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway.
authors.forename: Knut J
authors.initials: KJ
authors.lastname: Labori
mesh_terms: D000368:Aged; D064591:Allografts; D016063:Blood Loss, Surgical; D002102:Cadaver; D003080:Cold Temperature / Q000009:adverse effects; D005240:Feasibility Studies; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007084:Iliac Vein / Q000000981:diagnostic imaging / Q000637:transplantation*; D008297:Male; D008642:Mesenteric Veins / Q000601:surgery*; D008875:Middle Aged; D061646:Operative Time; D009926:Organ Preservation / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D010180:Pancreatectomy / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D016577:Pancreaticoduodenectomy / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D010690:Phlebography / Q000379:methods; D011169:Portal Vein / Q000601:surgery*; D012086:Reoperation; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D014019:Tissue Donors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D018608:Ultrasonography, Doppler; D014654:Vascular Patency