title: [Latest Advance of Study on Pathogenesis of Immune Thrombocytopenia].
abstract: Immune thrombocytopenia (ITP) is recognized as a multifactorial cell-specific autoimmune disorder, and its pathogenesis is still not very clear. Traditional concept suggests that the platelet destruction mediated by autoantibodies is the pathophysiology mechanism of ITP, while many studies in recent years have shown that the abnormities of T lymphocyte, dendritic cell (DC), natural killer cell (NK), cytokine, programmed cell death (PCD), oxidative stress (OS), infection, pregnancy and drugs etc play an important role in the pathogenesis of ITP. Since the study of ITP has made a series of important achievements in recent years, this review focuses on the latest advance of studies on pathogenesis of ITP.
authors.affiliation: Department of Pediatrics, Affiliated Hospital of Luzhou Medical College, Luzhou 64600, Sichuan Province, China.
authors.forename: Min
authors.initials: M
authors.lastname: Yang
authors.affiliation: Department of Pediatrics, Affiliated Hospital of Luzhou Medical College, Luzhou 64600, Sichuan Province, China. E-mail: lwjlyfy@sina.com.
authors.forename: Wen-Jun
authors.initials: WJ
authors.lastname: Liu
mesh_terms: D017209:Apoptosis; D001323:Autoantibodies / Q000097:blood; D016207:Cytokines / Q000097:blood; D003713:Dendritic Cells / Q000473:pathology; D006801:Humans; D007694:Killer Cells, Natural / Q000473:pathology; D018384:Oxidative Stress; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000503:physiopathology*; D013601:T-Lymphocytes / Q000473:pathology
chemical_list: D001323:Autoantibodies; D016207:Cytokines