title: Evaluation of the degradation of acetaminophen by the filamentous fungus Scedosporium dehoogii using carbon-based modified electrodes.
abstract: The nonpathogenic filamentous fungus Scedosporium dehoogii was used for the first time to study the electrochemical biodegradation of acetaminophen (APAP). A carbon fiber microelectrode (CFME) modified by nickel tetrasulfonated phthalocyanine (p-NiTSPc) and a carbon paste electrode (CPE) modified with coffee husks (CH) were prepared to follow the kinetics of APAP biodegradation. The electrochemical response of APAP at both electrodes was studied by cyclic voltammetry and square wave voltammetry. p-NiTSPc-CFME was suitable to measure high concentrations of APAP, whereas CH-CPE gave rise to high current densities but was subject to the passivation phenomenon. p-NiTSPc-CFME was then successfully applied as a sensor to describe the kinetics of APAP biodegradation: this was found to be of first order with a kinetics constant of 0.11 day(-1) (at 25 °C) and a half-life of 6.30 days. APAP biodegradation by the fungus did not lead to the formation of p-aminophenol (PAP) and hydroquinone (HQ) that are carcinogenic, mutagenic, and reprotoxic (CMR). Graphical Abstract The kinetics of APAP biodegradation, followed by a poly-nickel tetrasulfonated phtalocyanine modified carbon fiber microelectrode.
authors.affiliation: Electrochemistry and Chemistry of Materials, Department of Chemistry, University of Dschang, P.O. Box 67 Dschang, Dschang, West 237, Cameroon.|L'UNAM Université, Angers University, GEPEA, UMR-CNRS 6144, 2 Bd. Lavoisier, 49045, Angers, France.|L'UNAM Université, Angers University, GEIHP, EA 3142, Institut de Biologie en Santé PBH-IRIS, CHU, 4 rue Larrey, 49933, Angers, France.
authors.forename: Serge Foukmeniok
authors.initials: SF
authors.lastname: Mbokou
authors.affiliation: L'UNAM Université, Angers University, GEPEA, UMR-CNRS 6144, 2 Bd. Lavoisier, 49045, Angers, France.|L'UNAM Université, Angers University, GEIHP, EA 3142, Institut de Biologie en Santé PBH-IRIS, CHU, 4 rue Larrey, 49933, Angers, France.
authors.forename: Maxime
authors.initials: M
authors.lastname: Pontié
authors.affiliation: L'UNAM Université, Angers University, GEIHP, EA 3142, Institut de Biologie en Santé PBH-IRIS, CHU, 4 rue Larrey, 49933, Angers, France.
authors.forename: Bienvenue
authors.initials: B
authors.lastname: Razafimandimby
authors.affiliation: L'UNAM Université, Angers University, GEIHP, EA 3142, Institut de Biologie en Santé PBH-IRIS, CHU, 4 rue Larrey, 49933, Angers, France.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Bouchara
authors.affiliation: Electrochemistry and Chemistry of Materials, Department of Chemistry, University of Dschang, P.O. Box 67 Dschang, Dschang, West 237, Cameroon.
authors.forename: Evangéline
authors.initials: E
authors.lastname: Njanja
authors.affiliation: Electrochemistry and Chemistry of Materials, Department of Chemistry, University of Dschang, P.O. Box 67 Dschang, Dschang, West 237, Cameroon. ignas.tonle@univ-dschang.org.
authors.forename: Ignas
authors.initials: I
authors.lastname: Tonle Kenfack
mesh_terms: D000082:Acetaminophen / Q000032:analysis / Q000378:metabolism*; D018712:Analgesics, Non-Narcotic / Q000032:analysis / Q000378:metabolism*; D001673:Biodegradation, Environmental; D002244:Carbon / Q000737:chemistry; D055664:Electrochemical Techniques / Q000379:methods; D004785:Environmental Pollutants / Q000032:analysis / Q000378:metabolism*; D007211:Indoles / Q000737:chemistry; D054833:Isoindoles; D008839:Microelectrodes; D021681:Scedosporium / Q000378:metabolism*
chemical_list: D018712:Analgesics, Non-Narcotic; D004785:Environmental Pollutants; D007211:Indoles; D054833:Isoindoles; D000082:Acetaminophen; D002244:Carbon; C013647:phthalocyanine
keywords: Acetaminophen; Biodegradation; Carbon-based electrodes; Kinetics; Scedosporium dehoogii