title: Portal hypertension with extensive fibrosis and plasma cell infiltration in multiple myeloma.
abstract: Plasma cell infiltration of the liver has been described in about 45% of patient with multiple myeloma in autopsy review; however, it is usually not associated with significant liver dysfunction. Indeed, only rare cases of massive plasma cell infiltration leading to non-obstructive cholestasis and hepatic failure have been described. Here, we report a case with a history of 8 years of MM with extensive liver fibrosis and portal hypertension with no other evidence aetiology unless massive plasma cell infiltration who presented a significant regression of both biological liver abnormalities and liver stiffness after ten months of chemotherapy concomitantly to a significant decrease of the IgG serum monoclonal band.
authors.affiliation: Reims Teaching Hospitals, Robert-Debré Hospital, Department of Internal Medicine, Infectious Diseases, and Clinical Immunology, 51092 Reims, France.
authors.forename: Raphael
authors.initials: R
authors.lastname: Cohen
authors.affiliation: Reims Teaching Hospitals, Robert-Debré Hospital, Pathology Department, 51092 Reims, France.
authors.forename: Camille
authors.initials: C
authors.lastname: Boulagnon
authors.affiliation: Reims Teaching Hospitals, Robert-Debré Hospital, Gastroenterology Department, 51092 Reims, France.
authors.forename: Florent
authors.initials: F
authors.lastname: Ehrhard
authors.affiliation: Reims Teaching Hospitals, Robert-Debré Hospital, Pathology Department, 51092 Reims, France.
authors.forename: Marie-Danièle
authors.initials: MD
authors.lastname: Diebold
authors.affiliation: Reims Teaching Hospitals, Robert-Debré Hospital, Department of Internal Medicine, Infectious Diseases, and Clinical Immunology, 51092 Reims, France.
authors.forename: Yohan
authors.initials: Y
authors.lastname: Nguyen
authors.affiliation: Reims Teaching Hospitals, Robert-Debré Hospital, Department of Internal Medicine, Infectious Diseases, and Clinical Immunology, 51092 Reims, France.
authors.forename: Aurélien
authors.initials: A
authors.lastname: Giltat
authors.affiliation: Reims Teaching Hospitals, Robert-Debré Hospital, Department of Internal Medicine, Infectious Diseases, and Clinical Immunology, 51092 Reims, France.
authors.forename: Anthony
authors.initials: A
authors.lastname: Corchia
authors.affiliation: Reims Teaching Hospitals, Robert-Debré Hospital, Laboratory of Haematology, 51092 Reims, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Pignon
authors.affiliation: Reims Teaching Hospitals, Robert-Debré Hospital, Department of Internal Medicine, Infectious Diseases, and Clinical Immunology, 51092 Reims, France. Electronic address: fbanisadr@chu-reims.fr.
authors.forename: Firouzé
authors.initials: F
authors.lastname: Bani-Sadr
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications*; D007074:Immunoglobulin G / Q000097:blood; D008099:Liver / Q000473:pathology*; D008103:Liver Cirrhosis / Q000473:pathology*; D009101:Multiple Myeloma / Q000150:complications / Q000473:pathology*; D010950:Plasma Cells / Q000473:pathology*
chemical_list: D007074:Immunoglobulin G