title: Identification and Mechanistic Studies of a Cell Cycle Regulator JP18 from a Library of Synthetic Indole Terpenoid Mimics.
abstract: We constructed a small library of indole terpenoid mimics using a hybridizing strategy to link various indole and α,β-unsaturated enone building blocks together. Prepared compounds were evaluated for the cytotoxicity against a panel of cancer cell lines. An indolyl ketone called JP18 was identified as a cell cycle regulator, and the underlying mechanism was investigated.
authors.affiliation: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China.
authors.forename: Jinpeng
authors.initials: J
authors.lastname: Pei
authors.affiliation: State Key Laboratory of Bioorganic and Natural Products Chemistry, Collaborative Innovation Center of Chemistry for Life Sciences, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China.
authors.forename: Shupeng
authors.initials: S
authors.lastname: Zhou
authors.affiliation: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Bioorganic and Natural Products Chemistry, Collaborative Innovation Center of Chemistry for Life Sciences, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Sun
authors.affiliation: State Key Laboratory of Bioorganic and Natural Products Chemistry, Collaborative Innovation Center of Chemistry for Life Sciences, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China. ali@sioc.ac.cn.
authors.forename: Ang
authors.identifier: http://orcid.org/0000-0002-8808-0636
authors.initials: A
authors.lastname: Li
authors.affiliation: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China. wdzhangy@hotmail.com.|Department of Phytochemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai, 200433, China. wdzhangy@hotmail.com.
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Zhang
authors.affiliation: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China. heweiwei@ecust.edu.cn.
authors.forename: Weiwei
authors.initials: W
authors.lastname: He
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D018844:Cyclin-Dependent Kinases / Q000737:chemistry / Q000378:metabolism; D016213:Cyclins / Q000737:chemistry / Q000378:metabolism; D059565:G2 Phase Cell Cycle Checkpoints / Q000187:drug effects; D006801:Humans; D007211:Indoles / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry* / Q000633:toxicity; D059566:M Phase Cell Cycle Checkpoints / Q000187:drug effects; D013729:Terpenes / Q000737:chemistry* / Q000633:toxicity
chemical_list: D016213:Cyclins; D007211:Indoles; D007659:Ketones; D013729:Terpenes; C030374:indole; D018844:Cyclin-Dependent Kinases
keywords: CDK/cyclin complexes; cell cycle arrest; hybrid structures; indoles; terpenoids