title: Integration and Analysis of Heterogeneous Colorectal Cancer Data for Translational Research.
abstract: Cancer is the number one cause of death in Australia with colorectal cancer being the second most common cancer type. The translation of cancer research into clinical practice is hindered by the lack of integration of heterogeneous and autonomous data from various data sources. Integration of heterogeneous data can offer researchers a comprehensive source for biospecimen identification, hypothesis formulation, hypothesis validation, cohort discovery and biomarker discovery. Alongside the increasing prominence of big data, various translational research tools such as tranSMART have emerged that can converge and analyse different types of data. In this study, we show the integration of different data types from a significant Australian colorectal cancer cohort. Additionally, colorectal cancer datasets from The Cancer Genome Atlas were also integrated for comparison. These integrated data are accessible via http://www.tcrn.unsw.edu.au/transmart. The use of translational research tools for data integration can provide a cost-effective and rapid approach to translational cancer research.
authors.affiliation: Prince of Wales Clinical School, UNSW Australia.
authors.forename: Jitendra
authors.initials: J
authors.lastname: Jonnagaddala
authors.affiliation: Prince of Wales Clinical School, UNSW Australia.
authors.forename: Joanne L
authors.initials: JL
authors.lastname: Croucher
authors.affiliation: Prince of Wales Clinical School, UNSW Australia.
authors.forename: Toni Rose
authors.initials: TR
authors.lastname: Jue
authors.affiliation: Prince of Wales Clinical School, UNSW Australia.
authors.forename: Nicola S
authors.initials: NS
authors.lastname: Meagher
authors.affiliation: Prince of Wales Clinical School, UNSW Australia.
authors.forename: Lena
authors.initials: L
authors.lastname: Caruso
authors.affiliation: Office of DVC-Research, University of Queensland.
authors.forename: Robyn
authors.initials: R
authors.lastname: Ward
authors.affiliation: School of Medicine, University of Queensland, St Lucia, Australia.
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Hawkins
mesh_terms: D015415:Biomarkers; D015179:Colorectal Neoplasms / Q000209:etiology / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D003627:Data Interpretation, Statistical; D006801:Humans; D013223:Statistics as Topic; D057170:Translational Research, Biomedical / Q000379:methods
chemical_list: D015415:Biomarkers