title: The use of a biocompatible cement in endodontic surgery. A randomized clinical trial 1.
abstract: OBJECTIVE
  To evaluate the clinical applicability of Pozzolana Biologic Silva cement (PBS(r)) in endodontic surgery.
  
  
  METHODS
  Persistent apical periodontitis was diagnosed in 30 teeth of 12 patients by cone-beam computed tomography (CT). All patients had 2 or 4 affected teeth and underwent endodontic surgery with root-end filling. Patients with 2 affected teeth had one tooth (control) treated with mineral trioxide aggregate (MTA-Angelus(r)) as a root-end filling material, and the other tooth treated with PBS (experiment). When the patient had four affected teeth, two of them were treated with MTA and two with PBS. Six months after surgery, all patients were assessed by CT scan. Between-group comparisons of measurements were performed using the Wilcoxon test.
  
  
  RESULTS
  Periradicular tissue regeneration was observed in all cases. Significant within-group differences in long axes of the lesion were found in the bucco-palatal direction (PBS group, p=0.0012; MTA group, p=0.024) and coronal-apical direction (PBS group, p=0.0007; MTA group, p=0.0015) between pre- and postoperative measurements.
  
  
  CONCLUSIONS
  Pozzolana Biologic Silva cement can be used in the treatment of persistent periradicular lesions. The clinical use of PBS as a root-end filling material may be an alternative to MTA. PBS has additives, which provide enhanced strength.
authors.affiliation: Fellow Master degree, Professional Master's Program in Applied Health, Universidade di Vale do Sapucaí (UNIVÁS), Pouso Alegre-MG, and Universidade Federal de São Paulo (UNIFESP), Sao Paulo-SP, Brazil. Conception, design, intellectual and scientific content of the study; acquisition, interpretation and analysis of data; manuscript writing.
authors.forename: Sérgio Ribeiro da
authors.initials: SR
authors.lastname: Silva
authors.affiliation: PhD, Associate Professor, Professional Master's Program in Applied Health Sciences, UNIVÁS, Pouso Alegre-MG, Brazil. Conception, design, intellectual and scientific content of the study; acquisition, interpretation and analysis of data; manuscript writing; critical revision.
authors.forename: José Dias da
authors.initials: JD
authors.lastname: Silva
authors.affiliation: PhD, Full Professor, Department of Surgery, UNIVÁS, Pouso Alegre-MG, Brazil. Conception, design, intellectual and scientific content of the study; interpretation and analysis of data; critical revision.
authors.forename: Taylor Brandão
authors.initials: TB
authors.lastname: Schnaider
authors.affiliation: PhD, Full Professor, Department of Surgery, UNIFESP, Sao Paulo-SP, and UNIVÁS, Pouso Alegre-MG, Brazil. Interpretation and analysis of data, critical revision.
authors.forename: Daniela Francescato
authors.initials: DF
authors.lastname: Veiga
authors.affiliation: PhD, Department of Biostatistics, UNIVÁS, Pouso Alegre-MG, Brazil. Statistical analysis.
authors.forename: Neil Ferreira
authors.initials: NF
authors.lastname: Novo
authors.affiliation: PhD, Full Professor, Department of Biostatistics, UNIVÁS, Pouso Alegre-MG, Brazil. Interpretation of data, statistical analysis, critical revision.
authors.forename: Marcos
authors.initials: M
authors.lastname: Mesquita
authors.affiliation: PhD, Full Professor, Department of Surgery, UNIFESP, Sao Paulo-SP, Brazil. Interpretation and analysis of data, critical revision.
authors.forename: Lydia Masako
authors.initials: LM
authors.lastname: Ferreira
mesh_terms: D000293:Adolescent; D000328:Adult; D017607:Aluminum Compounds / Q000627:therapeutic use*; D001047:Apicoectomy / Q000379:methods; D001672:Biocompatible Materials / Q000627:therapeutic use*; D017610:Calcium Compounds / Q000627:therapeutic use*; D054893:Cone-Beam Computed Tomography; D003738:Dental Cements / Q000627:therapeutic use*; D004338:Drug Combinations; D006801:Humans; D008875:Middle Aged; D010087:Oxides / Q000627:therapeutic use*; D010485:Periapical Periodontitis / Q000000981:diagnostic imaging / Q000601:surgery*; D011184:Postoperative Period; D011446:Prospective Studies; D012038:Regeneration / Q000502:physiology; D012387:Root Canal Filling Materials / Q000627:therapeutic use*; D017640:Silicates / Q000627:therapeutic use*; D014092:Tooth Root / Q000000981:diagnostic imaging / Q000601:surgery; D055815:Young Adult
chemical_list: D017607:Aluminum Compounds; D001672:Biocompatible Materials; D017610:Calcium Compounds; D003738:Dental Cements; D004338:Drug Combinations; D010087:Oxides; D012387:Root Canal Filling Materials; D017640:Silicates; C086631:mineral trioxide aggregate