title: Clinical study of total glucosides of paeony for the treatment of diabetic kidney disease in patients with diabetes mellitus.
abstract: OBJECTIVE
  Total glucosides of paeony (TGP), an active compound extracted from dried roots of Paeonia lactiflora Pall, have anti-inflammatory effects. This study investigated the efficacy and safety of TGP for treating diabetic kidney disease (DKD) in type 2 diabetes mellitus patients.
  
  
  METHODS
  An open-label, prospective, randomized, parallel-group, single-site study involving 76 patients with DKD. Patients were randomized into two groups: losartan group (n = 38), treated with losartan 100 mg/day for 6 months and TGP group (n = 38), treated with TGP 1800 mg/day and losartan 100 mg/day for 6 months. Serum hs-CRP, MCP-1, and TNF-α were determined before and after treatment. Urinary albumin excretion rate (UAER), fasting blood glucose, serum creatinine, and lipid profiles were examined.
  
  
  RESULTS
  At the end-point, UAER decreased in the TGP group compared with baseline. UAER in the losartan group decreased to a level lower than before treatment. The rate of decline in the losartan group was significantly lower than the TGP group. There were no significant differences in serum creatinine and albumin levels between TGP and losartan groups at the end-point. Serum hs-CRP, MCP-1, and TNF-α levels were significantly lower in both groups after treatment. After treatment, serum hs-CRP, MCP-1, and TNF-α in the TGP group decreased more than the losartan group. Positive correlations were observed between UAER and hs-CRP, MCP-1, and TNF-α. No statistically significant difference in side effects was observed between groups.
  
  
  CONCLUSIONS
  Our study showed that TGP treatment could reduce the albuminuria and inflammatory markers in type 2 diabetes mellitus patients with DKD.
authors.affiliation: Department of Nephrology, The First Affiliated Hospital, Anhui Medical University, Hefei, 230022, Anhui, China.
authors.forename: Qijin
authors.initials: Q
authors.lastname: Zhu
authors.affiliation: Department of Nephrology, The First Affiliated Hospital, Anhui Medical University, Hefei, 230022, Anhui, China.
authors.forename: Xiangming
authors.initials: X
authors.lastname: Qi
authors.affiliation: Department of Nephrology, The First Affiliated Hospital, Anhui Medical University, Hefei, 230022, Anhui, China. wuyonggui@medmail.com.cn.
authors.forename: Yonggui
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Nephrology, The First Affiliated Hospital, Anhui Medical University, Hefei, 230022, Anhui, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Wang
mesh_terms: D000328:Adult; D000419:Albuminuria / Q000652:urine; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001786:Blood Glucose / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D018932:Chemokine CCL2 / Q000097:blood; D003404:Creatinine / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications; D003928:Diabetic Nephropathies / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D004359:Drug Therapy, Combination; D005260:Female; D005960:Glucosides / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D019808:Losartan / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D029596:Paeonia; D008517:Phytotherapy; D010936:Plant Extracts / Q000009:adverse effects / Q000627:therapeutic use*; D018517:Plant Roots; D011446:Prospective Studies; D012709:Serum Albumin / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D000959:Antihypertensive Agents; D001786:Blood Glucose; C111835:CCL2 protein, human; D018932:Chemokine CCL2; D005960:Glucosides; D010936:Plant Extracts; D012709:Serum Albumin; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein; D003404:Creatinine; D019808:Losartan
keywords: Albumin excretion rate; Diabetic kidney disease; Inflammation; Total glucosides of paeony