title: Constructing Slow-Release Formulations of Metribuzin Based on Degradable Poly(3-hydroxybutyrate).
abstract: Experimental formulations of herbicide metribuzin embedded in matrices of degradable natural polymer poly(3-hydroxybutyrate) (P3HB) and its composites with poly(ethylene glycol) (PEG), poly-ε-caprolactone (PCL), and wood powder have been prepared in the form of pressed pellets containing 75% polymeric basis (pure P3HB or its composite with a second component at a ratio of 7:3) and 25% metribuzin. Incubation of formulations in soil laboratory systems led to the degradation of the matrix and herbicide release. The most active release of metribuzin (about 60% of the embedded herbicide over 35 days) was detected for the P3HB/PEG carrier compared to the P3HB, P3HB/wood, and P3HB/PCL forms (30-40%). Thus, the study shows that herbicide release can be controlled by the matrix formulation. Metribuzin formulations exerted a significant herbicidal effect on the plant Agrostis stolonifera, used as a weed plant model. Application of these long-term formulations will make it possible to reduce environmental release of chemicals, which will restrict the rate of their accumulation in trophic chains of ecosystems and abate their adverse effects on the biosphere.
authors.affiliation: Institute of Biophysics of Siberian Branch of Russian Academy of Sciences , 50/50 Akademgorodok, Krasnoyarsk 660036, Russia.
authors.forename: Anatoly Nikolayevich
authors.initials: AN
authors.lastname: Boyandin
authors.affiliation: Institute of Biophysics of Siberian Branch of Russian Academy of Sciences , 50/50 Akademgorodok, Krasnoyarsk 660036, Russia.
authors.forename: Natalia Olegovna
authors.initials: NO
authors.lastname: Zhila
authors.affiliation: Institute of Biophysics of Siberian Branch of Russian Academy of Sciences , 50/50 Akademgorodok, Krasnoyarsk 660036, Russia.
authors.forename: Evgeniy Gennadievich
authors.initials: EG
authors.lastname: Kiselev
authors.affiliation: Institute of Biophysics of Siberian Branch of Russian Academy of Sciences , 50/50 Akademgorodok, Krasnoyarsk 660036, Russia.
authors.forename: Tatiana Grigorievna
authors.initials: TG
authors.lastname: Volova
mesh_terms: D031703:Agrostis / Q000737:chemistry / Q000187:drug effects; D003692:Delayed-Action Preparations / Q000737:chemistry* / Q000494:pharmacology; D004339:Drug Compounding / Q000295:instrumentation / Q000379:methods*; D006540:Herbicides / Q000737:chemistry* / Q000494:pharmacology; D006885:Hydroxybutyrates / Q000737:chemistry*; D007700:Kinetics; D011091:Polyesters / Q000737:chemistry*; D014227:Triazines / Q000737:chemistry* / Q000494:pharmacology; D000094122:Polyhydroxybutyrates
chemical_list: D003692:Delayed-Action Preparations; D006540:Herbicides; D006885:Hydroxybutyrates; D011091:Polyesters; D014227:Triazines; C003182:poly-beta-hydroxybutyrate; D000094122:Polyhydroxybutyrates; C009235:metribuzin
keywords: controlled release; degradable poly(3-hydroxybutyrate); herbicide; metribuzin; release kinetics