title: Feasibility and Safety of Hydrogen Gas Inhalation for Post-Cardiac Arrest Syndrome　- First-in-Human Pilot Study.
abstract: BACKGROUND
  Hydrogen gas inhalation (HI) ameliorates cerebral and cardiac dysfunction in animal models of post-cardiac arrest syndrome (PCAS). HI for human patients with PCAS has never been studied.
  
  
  RESULTS
  Between January 2014 and January 2015, 21 of 107 patients with out-of-hospital cardiac arrest achieved spontaneous return of circulation. After excluding 16 patients with specific criteria, 5 patients underwent HI together with target temperature management (TTM). No undesirable effects attributable to HI were observed and 4 patients survived 90 days with a favorable neurological outcome.
  
  
  CONCLUSIONS
  HI in combination with TTM is a feasible therapy for patients with PCAS. (Circ J 2016; 80: 1870-1873).
authors.affiliation: Department of Emergency and Critical Care Medicine, Keio University School of Medicine.
authors.forename: Tomoyoshi
authors.initials: T
authors.lastname: Tamura
authors.forename: Kei
authors.initials: K
authors.lastname: Hayashida
authors.forename: Motoaki
authors.initials: M
authors.lastname: Sano
authors.forename: Masaru
authors.initials: M
authors.lastname: Suzuki
authors.forename: Takayuki
authors.initials: T
authors.lastname: Shibusawa
authors.forename: Joe
authors.initials: J
authors.lastname: Yoshizawa
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Suzuki
authors.forename: Shigeo
authors.initials: S
authors.lastname: Ohta
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morisaki
authors.forename: Keiichi
authors.initials: K
authors.lastname: Fukuda
authors.forename: Shingo
authors.initials: S
authors.lastname: Hori
mesh_terms: D000368:Aged; D005260:Female; D006323:Heart Arrest / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D006859:Hydrogen / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011446:Prospective Studies
chemical_list: D006859:Hydrogen