title: Psychogenic non-epileptic seizures in early Huntington's disease.
abstract: Huntington's disease (HD) is a neurodegenerative condition characterised by motor dysfunction with involuntary movements and loss of voluntary control, cognitive deterioration and psychiatric problems. We report a 51-year-old man with early HD who experienced stereotyped episodes of repetitive, purposeless complex movements and unresponsiveness. His neurological examination was compatible with HD as were all investigations. We diagnosed psychogenic non-epileptic seizures. While seizures are common in juvenile-onset HD, they are no more prevalent in adult-onset HD than in the general population. However, neuropsychiatric symptoms are common in HD and can involve a number of different complaints. Patients may experience dissociative attacks soon after manifesting a HD diagnosis. Such episodes can be managed with patient and carer education, cognitive behavioural therapy and anxiolytic selective serotonin reuptake inhibitors.
authors.affiliation: Huntington's Disease Centre, Institute of Neurology, University College London, London, UK.
authors.forename: Filipe Brogueira
authors.identifier: http://orcid.org/0000-0002-5567-7938
authors.initials: FB
authors.lastname: Rodrigues
authors.affiliation: Huntington's Disease Centre, Institute of Neurology, University College London, London, UK.
authors.forename: Edward J
authors.identifier: http://orcid.org/0000-0002-6921-7887
authors.initials: EJ
authors.lastname: Wild
mesh_terms: D003072:Cognition Disorders; D006801:Humans; D006816:Huntington Disease / Q000150:complications / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D015995:Prevalence; D012640:Seizures / Q000209:etiology*
keywords: Huntington disease; case reports; pseudoseizures