title: The genus Hymenocrater: a comprehensive review.
abstract: BACKGROUND
  The genus Hymenocrater Fisch. et Mey. (Lamiaceae) contains over 21 species in the world. Some species have been used in folk medicine around the world. The present review comprises the ethnopharmacological, phytochemical and therapeutic potential of various species of Hymenocrater.
  
  
  OBJECTIVE
  This review brings together most of the available scientific research regarding the genus Hymenocrater. Through this review, the authors hope to attract the attention of natural product researchers throughout the world to focus on the unexplored potential of Hymenocrater species.
  
  
  METHODS
  This review has been compiled using references from major databases such as Chemical Abstracts, Medicinal and Aromatic Plants Abstracts, ScienceDirect, SciFinder, Google Scholar, Scopus, PubMed, Springer Link and books, without limiting the dates of publication. General web searches were also carried out using Google and Yahoo search engines by applying some related search terms (e.g., Hymenocrater spp., phytochemical, pharmacological, extract, essential oil and traditional uses). The articles related to agriculture, ecology, and synthetic works and those using languages other than English or Persian have been excluded.
  
  
  RESULTS
  The genus Hymenocrater contains essential oil. Flavonoids, phenolic acids and terpenoids are important constituents of this genus. The pharmacological studies confirmed that the species of the genus Hymenocrater showed antimicrobial, antiparasitic, antioxidant, anticancer and antidiabetic activities.
  
  
  CONCLUSIONS
  This review discusses the current knowledge of Hymenocrater species that review therapeutic potential, especially their effects on the cancer cells and gaps offering opportunities for future research.
authors.affiliation: a Department of Medicinal Chemistry, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center , Mazandaran University of Medical Sciences , Sari , Iran.
authors.forename: Katayoun
authors.initials: K
authors.lastname: Morteza-Semnani
authors.affiliation: a Department of Medicinal Chemistry, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center , Mazandaran University of Medical Sciences , Sari , Iran.
authors.forename: Hamideh
authors.initials: H
authors.lastname: Ahadi
authors.affiliation: a Department of Medicinal Chemistry, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center , Mazandaran University of Medical Sciences , Sari , Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Hashemi
mesh_terms: D000818:Animals; D020834:Ethnopharmacology / Q000379:methods / Q000639:trends*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D006801:Humans; D019686:Lamiaceae; D009822:Oils, Volatile / Q000737:chemistry* / Q000302:isolation & purification / Q000627:therapeutic use; D008517:Phytotherapy / Q000379:methods / Q000639:trends*; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000627:therapeutic use; D013045:Species Specificity
chemical_list: D005419:Flavonoids; D009822:Oils, Volatile; D010936:Plant Extracts
keywords: Anticancer; Lamiaceae; antidiabetic; antimicrobial; antioxidant; antiparasitic; flavonoids; phenolic acids; terpenoids