title: Serum Levels of Substance P and Mortality in Patients with a Severe Acute Ischemic Stroke.
abstract: Substance P (SP), a member of tachykinin family, is involved in the inflammation of the central nervous system and in the appearance of cerebral edema. Higher serum levels of SP have been found in 18 patients with cerebral ischemia compared with healthy controls. The aim of our multi-center study was to analyze the possible association between serum levels of SP and mortality in ischemic stroke patients. We included patients with malignant middle cerebral artery infarction (MMCAI) and a Glasgow Coma Scale (GCS) lower than 9. Non-surviving patients at 30 days (n = 31) had higher serum concentrations of SP levels at diagnosis of severe MMCAI than survivors (n = 30) (p < 0.001). We found in multiple regression an association between serum concentrations of SP higher than 362 pg/mL and mortality at 30 days (Odds Ratio = 5.33; 95% confidence interval = 1.541-18.470; p = 0.008) after controlling for age and GCS. Thus, the major novel finding of our study was the association between serum levels of SP and mortality in patients suffering from severe acute ischemic stroke.
authors.affiliation: Intensive Care Unit, Hospital Universitario de Canarias, Ofra, s/n. La Laguna, Tenerife 38320, Spain. lorentemartin@msn.com.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Lorente
authors.affiliation: Intensive Care Unit, Hospital Universitario Nuestra Se&#241;ora Candelaria, Crta Rosario s/n, Santa Cruz Tenerife 38010, Spain. mar.martinvelasco@gmail.com.
authors.forename: María M
authors.initials: MM
authors.lastname: Martín
authors.affiliation: Unidad de Gen&#233;tica, Instituto de Enfermedades Tropicales y Salud P&#250;blica de Canarias, Universidad de La Laguna, Campus de Anchieta, Avda. Astrof&#237;sico Francisco S&#225;nchez s/n, La Laguna, Tenerife 38071, Spain. tacosalm@ull.edu.es.
authors.forename: Teresa
authors.initials: T
authors.lastname: Almeida
authors.affiliation: Laboratory Department, Hospital Universitario de Canarias, Ofra, s/n. La Laguna, Tenerife 38320, Spain. aperezcejas@gmail.com.
authors.forename: Antonia
authors.initials: A
authors.lastname: Pérez-Cejas
authors.affiliation: Intensive Care Unit, Hospital General La Palma, Buenavista de Arriba s/n, Bre&#241;a Alta, La Palma 38713, Spain. lramosgomez@gmail.com.
authors.forename: Luis
authors.initials: L
authors.lastname: Ramos
authors.affiliation: Intensive Care Unit, Hospital Cl&#237;nico Universitario de Valencia, Avda. Blasco Ib&#225;&#241;ez nº17-19, Valencia 46004, Spain. moni_begasa@hotmail.com.
authors.forename: Mónica
authors.initials: M
authors.lastname: Argueso
authors.affiliation: Servicio de Bioqu&#237;mica Cl&#237;nica, Complejo Hospitalario Universitario Insular Materno-Infantil, Plaza Dr. Pasteur s/n, Las Palmas de Gran Canaria 35016, Spain. mriarui@gobiernodecanarias.org.
authors.forename: Marta
authors.initials: M
authors.lastname: Riaño-Ruiz
authors.affiliation: Intensive Care Unit, Hospital Universitario Dr. Negr&#237;n, CIBERES. Barranco de la Ballena s/n, Las Palmas de Gran Canaria 35010, Spain. jsolvio@gobiernodecanarias.org.
authors.forename: Jordi
authors.initials: J
authors.lastname: Solé-Violán
authors.affiliation: Unidad de Gen&#233;tica, Instituto de Enfermedades Tropicales y Salud P&#250;blica de Canarias, Universidad de La Laguna, Campus de Anchieta, Avda. Astrof&#237;sico Francisco S&#225;nchez s/n, La Laguna, Tenerife 38071, Spain. mnhdez@ull.edu.es.
authors.forename: Mariano
authors.initials: M
authors.lastname: Hernández
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000097:blood* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000097:blood* / Q000401:mortality / Q000473:pathology; D013373:Substance P / Q000097:blood*; D015996:Survival Rate
chemical_list: D015415:Biomarkers; D013373:Substance P
keywords: cerebral infarction; mortality; stroke; substance P