title: Towards Predicting Protective Vaccine Responses in the Very Young.
abstract: Infectious diseases remain a major cause of death in infancy. Vaccination is a proven-effective strategy to reduce the risk of infectious diseases. However, important gaps remain in our understanding of vaccine responses in early life. Systems vaccinology has provided new insight into mechanisms and predictors of vaccine responses. However, systems vaccinology has not yet been systematically applied to infants younger than 12 months of age. Here, we review the knowledge gained from systems vaccinology studies of vaccines that are licensed for administration to infants. We propose that systems vaccinology should be applied to age-specific studies focused on protection, to derive the necessary insight for optimal design of vaccines for the very young.
authors.affiliation: Division of Infectious Diseases, Department of Pediatrics, University of British Columbia, BC Children's Hospital, Vancouver, Canada. Electronic address: tkollm@mac.com.
authors.forename: Tobias R
authors.initials: TR
authors.lastname: Kollmann
authors.affiliation: Institute for Medical Immunology, Université Libre de Bruxelles, Charleroi, Belgium.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Marchant
mesh_terms: D000367:Age Factors; D000818:Animals; D003140:Communicable Disease Control / Q000379:methods; D006801:Humans; D007107:Immune System / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D007109:Immunity; D017063:Outcome Assessment, Health Care; D011379:Prognosis; D014611:Vaccination; D014612:Vaccines / Q000276:immunology*
chemical_list: D014612:Vaccines