title: A Glucose Sensing Contact Lens: A Non-Invasive Technique for Continuous Physiological Glucose Monitoring.
abstract: We have developed a range of glucose sensing contact lenses, using a daily, disposable contact lens embedded with newly developed boronic acid containing fluorophores. Our findings show that our approach may be suitable for the continuous monitoring of tear glucose levels in the range 50-1000μM, which typically track blood glucose levels, which are ≈5-10 fold higher. Our non-invasive approach may well offer an alternative solution to current invasive glucose monitoring techniques for diabetes, such as "finger pricking."
authors.affiliation: Center for Fluorescence Spectroscopy, Department of Biochemistry and Molecular Biology, Medical Biotechnology Center, University of Maryland School of Medicine, Baltimore, Maryland.
authors.forename: Ramachandram
authors.initials: R
authors.lastname: Badugu
authors.affiliation: Center for Fluorescence Spectroscopy, Department of Biochemistry and Molecular Biology, Medical Biotechnology Center, University of Maryland School of Medicine, Baltimore, Maryland.
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Lakowicz
authors.affiliation: Center for Fluorescence Spectroscopy, Department of Biochemistry and Molecular Biology, Medical Biotechnology Center, University of Maryland School of Medicine, Baltimore, Maryland; Institute of Fluorescence and Center for Fluorescence Spectroscopy, Medical Biotechnology Center, University of Maryland Biotechnology Institute, Baltimore, Maryland.
authors.forename: Chris D
authors.initials: CD
authors.lastname: Geddes
keywords: Glucose monitoring; contact lens; continuous monitoring; non-invasive