title: Hepato- and gastro- protective activity of purified oat 1-3, 1-4-β-d-glucans of different molecular weight.
abstract: Protective and antioxidant properties of highly purified oat β-glucans of high and low molecular weight in liver and stomach were evaluated. The novelty in approach was to determine whether dietary β-glucans affect the parameters of oxidative stress directly in the stomach and indirectly in the liver, especially in inflammation states. Physicochemical properties e.g. viscoelastic was found as strictly dependent from molecular weight of oat β-glucans hence its metabolic activity could also show dependence. Three groups of rats were fed control diet and diet supplemented with low and high molecular weights oat β-glucans. Animals were divided into controls and individuals with experimentally induced intestinal inflammation. Most active in increasing of total antioxidant status was low molecular weight β-glucan. High molecular weight β-glucan supplementation inhibits lipid oxidation the most in LPS treated animals. The results obtained from experiment encourage for dietary intervention with oat β-glucans for stomach and liver protection during existing enteritis.
authors.affiliation: Chair of Nutritional Physiology, Department of Dietetics, Faculty of Human Nutrition and Consumer Sciences, Warsaw University of Life Sciences (SGGW), ul. Nowoursynowska 166, 02-787 Warsaw, Poland. Electronic address: sucheckad@wp.pl.
authors.forename: Dominika
authors.initials: D
authors.lastname: Suchecka
authors.affiliation: Bio-Ref Laboratory, Food Biotechnology Department, Faculty of Engineering and Economics, Wroclaw University of Economics, ul. Komandorska 118/120, 53-345 Wrocław, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Harasym
authors.affiliation: Division of Dietetics, Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences (SGGW), ul. Nowoursynowska 166, 02-787 Warsaw, Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Wilczak
authors.affiliation: Chair of Nutritional Physiology, Department of Dietetics, Faculty of Human Nutrition and Consumer Sciences, Warsaw University of Life Sciences (SGGW), ul. Nowoursynowska 166, 02-787 Warsaw, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Gromadzka-Ostrowska
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D019610:Cytoprotection / Q000187:drug effects*; D019587:Dietary Supplements; D005753:Gastric Mucosa / Q000378:metabolism; D008099:Liver / Q000166:cytology* / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008970:Molecular Weight; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013270:Stomach / Q000166:cytology* / Q000187:drug effects*; D047071:beta-Glucans / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D047071:beta-Glucans; C067858:beta-glucan, (1-3)(1-4)-
keywords: Antioxidant; Enteritis; Hepato-protective; Liver; Oat beta-glucan; Stomach