title: Fluid-structure interaction including volumetric coupling with homogenised subdomains for modeling respiratory mechanics.
abstract: In this article, a novel approach is presented for combining standard fluid-structure interaction with additional volumetric constraints to model fluid flow into and from homogenised solid domains. The proposed algorithm is particularly interesting for investigations in the field of respiratory mechanics as it enables the mutual coupling of airflow in the conducting part and local tissue deformation in the respiratory part of the lung by means of a volume constraint. In combination with a classical monolithic fluid-structure interaction approach, a comprehensive model of the human lung can be established that will be useful to gain new insights into respiratory mechanics in health and disease. To illustrate the validity and versatility of the novel approach, three numerical examples including a patient-specific lung model are presented. The proposed algorithm proves its capability of computing clinically relevant airflow distribution and tissue strain data at a level of detail that is not yet achievable, neither with current imaging techniques nor with existing computational models. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Institute for Computational Mechanics, Technische Universität München, Boltzmannstrasse 15, D-85748 Garching b. München, Germany.
authors.forename: Lena
authors.initials: L
authors.lastname: Yoshihara
authors.affiliation: Institute for Computational Mechanics, Technische Universität München, Boltzmannstrasse 15, D-85748 Garching b. München, Germany.
authors.forename: Christian J
authors.initials: CJ
authors.lastname: Roth
authors.affiliation: Institute for Computational Mechanics, Technische Universität München, Boltzmannstrasse 15, D-85748 Garching b. München, Germany.
authors.forename: Wolfgang A
authors.initials: WA
authors.lastname: Wall
mesh_terms: D000465:Algorithms; D006801:Humans; D008168:Lung / Q000502:physiology*; D008954:Models, Biological; D015656:Respiratory Mechanics
keywords: constraint; fluid-structure interaction; monolithic coupling; respiratory mechanics