title: New emergence pattern with variant porcine epidemic diarrhea viruses, South Korea, 2012-2015.
abstract: Since outbreaks of porcine epidemic diarrhea virus (PEDV) in the United States in 2013, explosive outbreaks of PED in South Korea have infected all age groups of pigs in 2014-2015year. This study analyzed a large collection of the Spike protein coding gene to infer the spatial-temporal diffusion history of PEDV. The studying results suggested that PEDVs in Korea belonged to different genogroups. While classical G1 was continuingly circulating between provinces of Korea, the pandemic G2a were recently introduced from China and USA. By the application of Bayesian phylogeographical analysis, this study demonstrated the spatial-temporal transmission of PEDVs within Korea. Of the recent emerged G2a viruses, J3142 strains showed potential recombination breakpoint (376-2,143nt) of S1 gene between KNU1303_Korea strain_G2a (KJ451046) and 45RWVCF0712_Thailand strain_G2b (KF724935). The pandemic G2a virus was partial neutralized by the antibodies invoked by the G1- based PED vaccine virus.
authors.affiliation: Department of Veterinary Medicine Virology Lab, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, DaeHakRo 1, GwanAk-Gu, Seoul, 151-742, Republic of Korea.
authors.forename: Hee-Chun
authors.initials: HC
authors.lastname: Chung
authors.affiliation: Department of Veterinary Medicine Virology Lab, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, DaeHakRo 1, GwanAk-Gu, Seoul, 151-742, Republic of Korea.
authors.forename: Jee-Hoon
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Veterinary Microbiology and Infectious Diseases, Faculty of Veterinary Medicine, Vietnam National University of Agriculture, Hanoi, Vietnam.
authors.forename: Van Giap
authors.initials: VG
authors.lastname: Nguyen
authors.affiliation: Department of Veterinary Microbiology and Infectious Diseases, Faculty of Veterinary Medicine, Vietnam National University of Agriculture, Hanoi, Vietnam.
authors.forename: Thi My Le
authors.initials: TML
authors.lastname: Huynh
authors.affiliation: Department of Veterinary Medicine Virology Lab, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, DaeHakRo 1, GwanAk-Gu, Seoul, 151-742, Republic of Korea.
authors.forename: Ga-Eun
authors.initials: GE
authors.lastname: Lee
authors.affiliation: Research Unit, Green Cross Veterinary Products, Yongin, Republic of Korea.
authors.forename: Hyoung-Joon
authors.initials: HJ
authors.lastname: Moon
authors.affiliation: Forensic Medicine Division, Daegu Institute, National Forensic Service, Chilgok 718-803, Republic of Korea.
authors.forename: Seong-Jun
authors.initials: SJ
authors.lastname: Park
authors.affiliation: Viral Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Republic of Korea.
authors.forename: Hye-Kwon
authors.initials: HK
authors.lastname: Kim
authors.affiliation: Department of Veterinary Medicine Virology Lab, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, DaeHakRo 1, GwanAk-Gu, Seoul, 151-742, Republic of Korea. Electronic address: parkx026@snu.ac.kr.
authors.forename: Bong Kyun
authors.initials: BK
authors.lastname: Park
mesh_terms: D000818:Animals; D021821:Communicable Diseases, Emerging / Q000662:veterinary*; D018352:Coronavirus Infections / Q000662:veterinary*; D003967:Diarrhea / Q000662:veterinary*; D049674:History, 21st Century; D010802:Phylogeny; D053485:Porcine epidemic diarrhea virus / Q000145:classification* / Q000235:genetics*; D016865:Reassortant Viruses; D011995:Recombination, Genetic; D056910:Republic of Korea / Q000453:epidemiology; D013552:Swine; D013553:Swine Diseases / Q000453:epidemiology* / Q000266:history / Q000821:virology*; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D014764:Viral Proteins
keywords: Isolation; Novel strains; Piglets; Porcine epidemic diarrhea virus; South Korea