title: Simple vaginal trachelectomy as a fertility-sparing treatment to manage high-grade dyskaryosis following multiple large loop excision of the transformation zone.
abstract: A 34-year-old nullipara, wishing to start a family, presented to colposcopy clinic. Her most recent cervical cytology result showed high-grade dyskaryosis. Having undergone four large loop excisions of the transformation zone during the past 6 years, this woman had no remaining vaginal cervix. In order to excise presumed high-grade cervical intraepithelial neoplasia while mitigating obstetric risk, she underwent a simple vaginal trachelectomy and isthmic cerclage. 6 months later, the patient had a negative test of cure. 7 months following surgery she became pregnant naturally. At 29 weeks she had antenatal sepsis of unknown cause, which was treated with intravenous antibiotics. She delivered by caesarean section at 37 weeks and now has a healthy child. This report will discuss the obstetric impact of colposcopic treatment, and simple vaginal trachelectomy as a fertility-sparing treatment option for women who have had multiple loop excision procedures to treat premalignant lesions.
authors.affiliation: Department of Health Sciences, University of Bristol, Bristol, UK.
authors.forename: Claire Grace
authors.initials: CG
authors.lastname: Scrivener
authors.affiliation: Department of Gynaecology, Cheltenham General Hospital, Cheltenham, UK.
authors.forename: Robert
authors.initials: R
authors.lastname: Gornall
authors.affiliation: Department of Gynaecology, Cheltenham General Hospital, Cheltenham, UK.
authors.forename: Philip
authors.initials: P
authors.lastname: Rolland
mesh_terms: D003127:Colposcopy / Q000379:methods; D005260:Female; D059247:Fertility Preservation / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging; D059351:Organ Sparing Treatments / Q000379:methods*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000601:surgery*; D011256:Pregnancy Outcome; D000069339:Trachelectomy / Q000379:methods*; D002583:Uterine Cervical Neoplasms / Q000601:surgery*; D002578:Uterine Cervical Dysplasia / Q000601:surgery*