title: Evolution of the Calcium-Based Intracellular Signaling System.
abstract: To progress our understanding of molecular evolution from a collection of well-studied genes toward the level of the cell, we must consider whole systems. Here, we reveal the evolution of an important intracellular signaling system. The calcium-signaling toolkit is made up of different multidomain proteins that have undergone duplication, recombination, sequence divergence, and selection. The picture of evolution, considering the repertoire of proteins in the toolkit of both extant organisms and ancestors, is radically different from that of other systems. In eukaryotes, the repertoire increased in both abundance and diversity at a far greater rate than general genomic expansion. We describe how calcium-based intracellular signaling evolution differs not only in rate but in nature, and how this correlates with the disparity of plants and animals.
authors.affiliation: Life Sciences Building, University of Bristol, United Kingdom GQE-Le Moulon, INRA, Univ. Paris-Sud, CNRS, AgroParisTech, Université Paris-Saclay, 91190 Gif-sur-Yvette, France elodie.marchadier@moulon.inra.fr.
authors.forename: Elodie
authors.initials: E
authors.lastname: Marchadier
authors.affiliation: Department of Computer Sciences, University of Bristol, United Kingdom.
authors.forename: Matt E
authors.initials: ME
authors.lastname: Oates
authors.affiliation: Department of Computer Sciences, University of Bristol, United Kingdom.
authors.forename: Hai
authors.initials: H
authors.lastname: Fang
authors.affiliation: Department of Earth Sciences, University of Bristol, United Kingdom.
authors.forename: Philip C J
authors.initials: PC
authors.lastname: Donoghue
authors.affiliation: Life Sciences Building, University of Bristol, United Kingdom.
authors.forename: Alistair M
authors.initials: AM
authors.lastname: Hetherington
authors.affiliation: Department of Computer Sciences, University of Bristol, United Kingdom.
authors.forename: Julian
authors.initials: J
authors.lastname: Gough
mesh_terms: D000818:Animals; D020013:Calcium Signaling / Q000235:genetics*; D002135:Calcium-Binding Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D056890:Eukaryota / Q000235:genetics; D019143:Evolution, Molecular
chemical_list: D002135:Calcium-Binding Proteins
keywords: calcium signaling; diversification; evolution; protein architecture; specialization