title: Management of post liver transplantation recurrent hepatitis C infection with directly acting antiviral drugs: a review.
abstract: Recurrent HCV infection (rHCV) of the liver allograft following transplantation is universal and is associated with poor graft and patient survival in comparison with other indications. Treatment of rHCV infection in the previous era with pegylated interferon and ribavirin was associated with low sustained virological response (SVR) due to poor tolerability, adverse events and graft rejection. Recently, directly acting antiviral drugs (DAA) have been approved for the treatment of hepatitis C infection and a number of clinical trials have been conducted across various centers in the management of rHCV infection of the graft. In this review we discuss about recent studies that have emerged on the use of NS5b polymerase inhibitor, sofosbuvir in combination with second generation protease inhibitor, simeprevir, fixed dose ledipasvir or daclatasvir with or without ribavirin in the treatment of post transplant rHCV infection.
authors.affiliation: Institute of Liver Disease and Transplantation, Global Hospital, Chennai, India. jdineshis@yahoo.co.uk.
authors.forename: Dinesh
authors.initials: D
authors.lastname: Jothimani
authors.affiliation: Institute of Liver Disease and Transplantation, Global Hospital, Chennai, India.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Govil
authors.affiliation: Institute of Liver Disease and Transplantation, Global Hospital, Chennai, India.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Rela
mesh_terms: D000998:Antiviral Agents / Q000008:administration & dosage* / Q000494:pharmacology; D004338:Drug Combinations; D016174:Hepacivirus / Q000187:drug effects / Q000201:enzymology; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D016031:Liver Transplantation; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D004338:Drug Combinations
keywords: Daclatasvir; Ledipasvir; Liver transplantation; Recurrent hepatitis C infection; Ribavirin; Sofosbuvir