title: Changes in lactate dehydrogenase are associated with central gray matter lesions in newborns with hypoxic-ischemic encephalopathy.
abstract: OBJECTIVE
  Biomarkers may predict neurological prognosis in infants with hypoxic-ischemic encephalopathy (HIE). We evaluated the relationship between serum lactate dehydrogenase (LDH) and brain magnetic resonance imaging (MRI), which predicts neurodevelopmental outcomes, in order to assess whether LDH levels are similarly predictive.
  
  
  METHODS
  Medical records were reviewed for infants with HIE and LDH levels were assessed on the first (LDH1) and third (LDH3) days following birth. Receiver operating characteristic curves were obtained in relation to central gray matter hypoxic-ischemic lesions.
  
  
  RESULTS
  Of 92 patients, 52 (56.5%) had hypoxic-ischemic lesions on brain MRI, and 21 of these infants (40.4%) had central gray matter lesions. LDH1and LDH3did not differ; however, the percentage change (ΔLDH%) was significantly higher in infants with central gray matter lesions (36.9% versus 6.6%, p = 0.006). With cutoffs of 187 (IU/L, ΔLDH) and 19.4 (%, ΔLDH%), the sensitivity, specificity, positive predictive value and negative predictive value were 71.4, 69.0, 40.5 and 89.1%, respectively. The relative risk was 5.57 (p = 0.001).
  
  
  CONCLUSIONS
  Changes in serum LDH may be a useful biomarker for predicting future neurodevelopmental prognosis in infants with HIE.
authors.affiliation: a Division of Neonatology , Department of Pediatrics, College of Medicine, The Catholic University of Korea , Seoul , Republic of Korea.
authors.forename: Sook Kyung
authors.initials: SK
authors.lastname: Yum
authors.affiliation: a Division of Neonatology , Department of Pediatrics, College of Medicine, The Catholic University of Korea , Seoul , Republic of Korea.
authors.forename: Cheong-Jun
authors.initials: CJ
authors.lastname: Moon
authors.affiliation: a Division of Neonatology , Department of Pediatrics, College of Medicine, The Catholic University of Korea , Seoul , Republic of Korea.
authors.forename: Young-Ah
authors.initials: YA
authors.lastname: Youn
authors.affiliation: a Division of Neonatology , Department of Pediatrics, College of Medicine, The Catholic University of Korea , Seoul , Republic of Korea.
authors.forename: In Kyung
authors.initials: IK
authors.lastname: Sung
mesh_terms: D015415:Biomarkers / Q000097:blood; D005260:Female; D066128:Gray Matter / Q000000981:diagnostic imaging*; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000175:diagnosis* / Q000201:enzymology; D007231:Infant, Newborn; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008279:Magnetic Resonance Imaging; D008297:Male; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D007770:L-Lactate Dehydrogenase
keywords: Central gray matter; hypoxic ischemic encephalopathy; lactate dehydrogenase; magnetic resonance imaging; neurodevelopment