title: Restoring stem cells - all you need is NAD(.).
abstract: The loss of stem cells, through cell dysfunction or senescence, is thought to contribute to biological aging. Recently, Hongbo Zhang and colleagues have shown that activation of the mitochondrial unfolded protein response, a retrograde stress response, through administration with an NAD-raising compound, can rejuvenate stem cells and extend lifespan in mice.
authors.affiliation: School of Medical Sciences, UNSW Australia, Sydney 2052, Australia.
authors.forename: Lindsay E
authors.initials: LE
authors.lastname: Wu
authors.affiliation: School of Medical Sciences, UNSW Australia, Sydney 2052, Australia.|Glenn Labs for the Biological Mechanisms of Aging, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Sinclair
mesh_terms: D000818:Animals; D008136:Longevity; D051379:Mice; D008928:Mitochondria; D009243:NAD; D013234:Stem Cells; D056811:Unfolded Protein Response
chemical_list: D009243:NAD