title: Functional and oncologic outcome of cemented endoprosthesis for malignant proximal femoral tumors.
abstract: BACKGROUND
  Cemented endoprosthetic replacement is an option for reconstruction of the proximal femur to achieve limb salvage. Existing outcome studies combine benign and malignant conditions, or group endoprostheses from multiple areas into one cohort. We sought to examine a series of endoprosthetic replacements of the proximal femur for a malignant process.
  
  
  METHODS
  We reviewed 204 patients who underwent an endoprosthesis for a malignant process of the proximal femur with at least 2-year follow-up. Mean age was 59 years, with 55% being male. The most common pathology was metastatic disease (n = 120, 59%). Mean follow-up was 7 years (2-22 years). Mean time to death was 2 years (range 2 weeks-18 years). A bipolar component was used in 93% of patients.
  
  
  RESULTS
  5-year survival was 8% in patients with metastatic disease and 54% for patients with primary disease. Local recurrence and metastatic disease developed in 5 and 19 patients with a primary sarcoma. Following the procedure the mean Harris Hip and Musculoskeletal Tumor Society Scores were 75 and 18.
  
  
  CONCLUSIONS
  Patients typically succumb to their disease prior to implant failure; however, endoprosthetic replacement provides patients with an acceptable means of functional recovery with an acceptable complication profile. J. Surg. Oncol. 2016;114:501-506. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Mayo Clinic, Department of Orthopedic Surgery, Rochester, Minnesota.
authors.forename: Matthew T
authors.initials: MT
authors.lastname: Houdek
authors.affiliation: Mayo Clinic, Department of Orthopedic Surgery, Rochester, Minnesota.
authors.forename: Chad D
authors.initials: CD
authors.lastname: Watts
authors.affiliation: Mayo Clinic, Department of Orthopedic Surgery, Rochester, Minnesota.
authors.forename: Cody C
authors.initials: CC
authors.lastname: Wyles
authors.affiliation: Mayo Clinic, Department of Orthopedic Surgery, Rochester, Minnesota.
authors.forename: Peter S
authors.initials: PS
authors.lastname: Rose
authors.affiliation: Mayo Clinic, Department of Orthopedic Surgery, Rochester, Minnesota.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Taunton
authors.affiliation: Mayo Clinic, Department of Orthopedic Surgery, Rochester, Minnesota.
authors.forename: Franklin H
authors.initials: FH
authors.lastname: Sim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D005266:Femoral Neoplasms / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D005269:Femur / Q000601:surgery*; D006801:Humans; D023821:Limb Salvage; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology; D019919:Prosthesis Implantation / Q000379:methods*; D019651:Plastic Surgery Procedures / Q000379:methods*; D012086:Reoperation
keywords: endoprosthesis; malignant; outcome; proximal femur