title: Adipokines, asymmetrical dimethylarginine, and pulmonary function in adolescents with asthma and obesity.
abstract: This study was to investigate whether the metabolic abnormalities of adipokines and asymmetrical dimethylarginine (ADMA) associate with pulmonary function deficits in adolescents with obesity and asthma.
  
  
  
  This study enrolled 28 obese adolescents with asthma, 46 obese adolescents without asthma, 58 normal-weight adolescents with asthma, and 63 healthy control subjects. Serum levels of leptin, high-molecule-weight (HMW) adiponectin, retinol binding protein 4 (RBP4), asymmetrical dimethylarginine (ADMA), and pulmonary function were qualified.
  
  
  
  The obese subjects had higher levels of leptin and ADMA but lower levels of HMW adiponectin than the normal-weight subjects with or without asthma. The subjects with asthma had higher levels of RBP4 than those without asthma. The obese adolescents with asthma had lowest forced expiratory lung volume in the first second (FEV1)/forced vital capacity (FVC) ratio among the four study groups. In all the study subjects and in the subjects with asthma alone, the FEV1/FVC ratio associated negatively with leptin, however, such association was rendered non-significant when adjusted for BMI. The pulmonary function deficits associated inversely with BMI percentile in the subjects with asthma. However, the decreased FEV1/FVC ratio was not correlated with HMW adiponectin, RBP4 or ADMA.
  
  
  
  Our present study confirmed obstructive pattern of pulmonary function characterized by the reduced FEV1/FVC ratio in the obese adolescents with asthma. These pulmonary deficits were associated inversely with the increased BMI percentile.
authors.affiliation: a Laboratory of Pharmacology and Toxicology, Hospital Infántil de México Federico Gómez (HIMFG) , Mexico City , Mexico.
authors.forename: Fengyang
authors.initials: F
authors.lastname: Huang
authors.affiliation: b Department of Allergy , Hospital Infántil de México Federico Gómez (HIMFG) , Mexico City , Mexico.
authors.forename: Blanca Estela
authors.initials: BE
authors.lastname: Del-Río-Navarro
authors.affiliation: a Laboratory of Pharmacology and Toxicology, Hospital Infántil de México Federico Gómez (HIMFG) , Mexico City , Mexico.
authors.forename: Saúl
authors.initials: S
authors.lastname: Torres-Alcántara
authors.affiliation: a Laboratory of Pharmacology and Toxicology, Hospital Infántil de México Federico Gómez (HIMFG) , Mexico City , Mexico.
authors.forename: José Alfredo
authors.initials: JA
authors.lastname: Pérez-Ontiveros
authors.affiliation: c Center Laboratory, Hospital Infántil de México Federico Gómez (HIMFG) , Mexico City , Mexico.
authors.forename: Eliseo
authors.initials: E
authors.lastname: Ruiz-Bedolla
authors.affiliation: b Department of Allergy , Hospital Infántil de México Federico Gómez (HIMFG) , Mexico City , Mexico.
authors.forename: Omar Josué
authors.initials: OJ
authors.lastname: Saucedo-Ramírez
authors.affiliation: d Superior School of Medicine, National Polytechnic Institute , Mexico City , Mexico.
authors.forename: Santiago
authors.initials: S
authors.lastname: Villafaña
authors.affiliation: e Departamento de Atención a la Salud , Instituto Nacional de Cardiología Ignacio Chávez , Mexico City , Mexico.
authors.forename: Fausto
authors.initials: F
authors.lastname: Sánchez Muñoz
authors.affiliation: f Department of Pharmacobiology , Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional , Mexico City , Mexico.
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Bravo
authors.affiliation: f Department of Pharmacobiology , Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional , Mexico City , Mexico.
authors.forename: Enrique
authors.initials: E
authors.lastname: Hong
mesh_terms: D054392:Adipokines / Q000378:metabolism*; D052242:Adiponectin / Q000378:metabolism; D000293:Adolescent; D001120:Arginine / Q000031:analogs & derivatives* / Q000378:metabolism; D001249:Asthma / Q000453:epidemiology* / Q000503:physiopathology*; D002648:Child; D005260:Female; D006801:Humans; D020738:Leptin / Q000378:metabolism; D008168:Lung / Q000503:physiopathology; D008297:Male; D063766:Pediatric Obesity / Q000453:epidemiology* / Q000503:physiopathology*; D012129:Respiratory Function Tests; D054839:Retinol-Binding Proteins, Plasma / Q000378:metabolism
chemical_list: D054392:Adipokines; D052242:Adiponectin; D020738:Leptin; C101326:RBP4 protein, human; D054839:Retinol-Binding Proteins, Plasma; C487735:dimethylarginine; C018524:N,N-dimethylarginine; D001120:Arginine
keywords: Adolescents; HMW adiponectin; RBP4; asthma; leptin; obesity