title: Self-Assembly of Disorazole C1through a One-Pot Alkyne Metathesis Homodimerization Strategy.
abstract: Alkyne metathesis is increasingly explored as a reliable method to close macrocyclic rings, but there are no prior examples of an alkyne-metathesis-based homodimerization approach to natural products. In this approach to the cytotoxicC2-symmetric marine-derived bis(lactone) disorazole C1, a highly convergent, modular strategy is employed featuring cyclization through an ambitious one-pot alkyne cross-metathesis/ring-closing metathesis self-assembly process.
authors.affiliation: EaStCHEM School of Chemistry, University of Edinburgh, David Brewster Road, Edinburgh, EH9 3FJ (UK).
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Ralston
authors.affiliation: EaStCHEM School of Chemistry, University of Edinburgh, David Brewster Road, Edinburgh, EH9 3FJ (UK).
authors.forename: H Clinton
authors.initials: HC
authors.lastname: Ramstadius
authors.affiliation: EaStCHEM School of Chemistry, University of Edinburgh, David Brewster Road, Edinburgh, EH9 3FJ (UK).
authors.forename: Richard C
authors.initials: RC
authors.lastname: Brewster
authors.affiliation: EaStCHEM School of Chemistry, University of Edinburgh, David Brewster Road, Edinburgh, EH9 3FJ (UK).
authors.forename: Helen S
authors.initials: HS
authors.lastname: Niblock
authors.affiliation: EaStCHEM School of Chemistry, University of Edinburgh, David Brewster Road, Edinburgh, EH9 3FJ (UK).
authors.forename: Alison N
authors.initials: AN
authors.lastname: Hulme
keywords: Alkinmetathese; Naturstoffe; Selbstorganisation; Totalsynthese; Zelltoxizität