title: Comparison of endoscopic and external resections for sinonasal instestinal-type adenocarcinoma.
abstract: Endoscopic sinus surgery (ESS) is considered as a valid option in the management of nasal adenocarcinoma (ADC). Comparative studies with open approaches are still required. A monocentric retrospective study was carried out from May 2002 to December 2013, including 43 patients with intestinal-type adenocarcinoma of the ethmoid sinus. Non-resectable tumours or recurrences were excluded. Before 2008, open approach with lateral rhinotomy (LR) was performed as the gold standard of treatment. From 2008, ESS was systematically used as a first-line option as long as a complete resection was achievable. Adjuvant radiation therapy was delivered (RT) for all the patients. LR and ESS were performed in, respectively, 23 and 20 patients. The two groups were comparable in terms of age, occupational dust exposure, histopathological subtypes, and T stage based on the pathological assessment of the specimen (10 pT2, 26 pT3, 2 pT4a, and 5 pT4b). The tumour origin was mainly located in the olfactory cleft with the involvement of the cribriform plate in 60 % of patients. No major complication was observed in ESS group with a reduced hospital stay (5.6 vs 7.6 days). The disease-free survival was not different between LR and ESS groups over a mean follow-up period of 6.6 years. Even for local advanced stages with skull base involvement, we confirm the reliability and the advantages of ESS in terms of oncological outcomes and morbidity. We advocate complete excision of the olfactory cleft to ensure an appropriate control of the tumoral origin.
authors.affiliation: Otorhinolaryngology-Head and Neck Surgery Department, University Hospital, Lille, France. geoffrey.mortuaire@chru-lille.fr.|Université de Lille 2, Lille, France. geoffrey.mortuaire@chru-lille.fr.|Service d'ORL de chirurgie cervico-faciale, Hôpital Huriez CHRU Lille, Lille, 59000, France. geoffrey.mortuaire@chru-lille.fr.
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Mortuaire
authors.affiliation: Université de Lille 2, Lille, France.|Pathology Department, University Hospital, Lille, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Leroy
authors.affiliation: Otorhinolaryngology-Head and Neck Surgery Department, University Hospital, Lille, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Vandenhende-Szymanski
authors.affiliation: Otorhinolaryngology-Head and Neck Surgery Department, University Hospital, Lille, France.|Université de Lille 2, Lille, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Chevalier
authors.affiliation: Otorhinolaryngology-Head and Neck Surgery Department, University Hospital, Lille, France.
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Thisse
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery*; D000368:Aged; D018572:Disease-Free Survival; D004724:Endoscopy; D005005:Ethmoid Sinus / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009300:Nasal Septum / Q000601:surgery; D009364:Neoplasm Recurrence, Local; D010255:Paranasal Sinus Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D018714:Radiotherapy, Adjuvant / Q000379:methods; D020266:Radiotherapy, Conformal / Q000379:methods; D015203:Reproducibility of Results; D012189:Retrospective Studies; D018709:Statistics, Nonparametric
keywords: Adenocarcinoma; Endoscopic surgery; Ethmoid; Olfactory cleft; Radiotherapy