title: Omental leiomyosarcoma with unusual giant cells in a Beagle dog - Short communication.
abstract: A 10-year-old castrated male Beagle dog was presented with a 2-month history of intermittent vomiting and abdominal pain. The dog was referred to the Veterinary Teaching Hospital at Iwate University for further evaluation, and a splenic tumour was suspected on the basis of ultrasonography and computed tomography. Surgery identified a large, solid, light-pink mass on the greater omentum with blood-coloured ascites in the abdominal cavity, and resection was performed. Microscopically, the mass comprised spindle-shaped tumour cells and scattered osteoclast-like giant cells. Most spindle-shaped cells were positive for vimentin, desmin, and smooth muscle actin (α-SMA), whereas osteoclast-like giant cells were positive only for vimentin. On the basis of histopathological and immunohistochemical findings, a diagnosis of leiomyosarcoma was made. To the best of our knowledge, this represents the first report of leiomyosarcoma associated with osteoclast-like giant cells developing from the greater omentum in a dog.
authors.affiliation: Department of Veterinary Pathology, Iwate University , 3-18-8 Ueda, Morioka, Iwate 020-8550 , Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Sasaki
authors.affiliation: Department of Veterinary Pathology, Iwate University , 3-18-8 Ueda, Morioka, Iwate 020-8550 , Japan.
authors.forename: Megumi
authors.initials: M
authors.lastname: Toyoshima
authors.affiliation: Veterinary Surgery, Faculty of Agriculture, Iwate University , 3-18-8 Ueda, Morioka, Iwate 020-8550 , Japan.
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Okamura
authors.affiliation: Department of Veterinary Pathology, Iwate University , 3-18-8 Ueda, Morioka, Iwate 020-8550 , Japan.
authors.forename: Masanobu
authors.initials: M
authors.lastname: Goryo
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D007890:Leiomyosarcoma / Q000473:pathology / Q000662:veterinary*; D008297:Male; D009852:Omentum / Q000473:pathology*; D010534:Peritoneal Neoplasms / Q000473:pathology / Q000662:veterinary*
keywords: Dog; greater omentum; leiomyosarcoma; osteoclast-like giant cell