title: Prevalence and concordance between the clinical and the post-mortem diagnosis of dementia in a psychogeriatric clinic.
abstract: BACKGROUND
  The aim of our study is to describe the types of dementia found in a series of patients and to estimate the level of agreement between the clinical diagnosis and post-mortem diagnosis.
  
  
  METHODS
  We conducted a descriptive analysis of the prevalence of the types of dementia found in our series and we established the level of concordance between the clinical and the post-mortem diagnoses. The diagnosis was made based on current diagnostic criteria.
  
  
  RESULTS
  114 cases were included. The most common clinical diagnoses both at a clinical and autopsy level were Alzheimer disease and mixed dementia but the prevalence was quite different. While at a clinical level, prevalence was 39% for Alzheimer disease and 18% for mixed dementia, in the autopsy level, prevalence was 22% and 34%, respectively. The agreement between the clinical and the autopsy diagnoses was 62% (95% CI 53-72%).
  
  
  CONCLUSIONS
  Almost a third of our patients were not correctly diagnosed in vivo. The most common mistake was the underdiagnosis of cerebrovascular pathology.
authors.affiliation: Servicio de Geriatría, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, España. Electronic address: beatrizgrandal@hotmail.com.
authors.forename: B
authors.initials: B
authors.lastname: Grandal Leiros
authors.affiliation: Unidad de Investigación, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife.
authors.forename: L I
authors.initials: LI
authors.lastname: Pérez Méndez
authors.affiliation: Navarrabiomed Fundación Miguel Servet, Complejo Hospitalario de Navarra Osasunbidea, Pamplona, España.
authors.forename: M V
authors.initials: MV
authors.lastname: Zelaya Huerta
authors.affiliation: Clínica Psicogeriátrica Josefina Arregui , Alsasua, Navarra, España.
authors.forename: L
authors.initials: L
authors.lastname: Moreno Eguinoa
authors.affiliation: Departamento de Anatomía Patológica, Complejo Hospitalario de Navarra Osasunbidea, Pamplona, España.
authors.forename: F
authors.initials: F
authors.lastname: García-Bragado
authors.affiliation: Departamento de Anatomía Patológica, Complejo Hospitalario de Navarra Osasunbidea, Pamplona, España.
authors.forename: T
authors.initials: T
authors.lastname: Tuñón Álvarez
authors.affiliation: Clínica Psicogeriátrica Josefina Arregui , Alsasua, Navarra, España.
authors.forename: J J
authors.initials: JJ
authors.lastname: Roldán Larreta
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology / Q000473:pathology*; D001344:Autopsy; D001921:Brain / Q000473:pathology*; D002561:Cerebrovascular Disorders; D060825:Cognitive Dysfunction / Q000453:epidemiology; D015140:Dementia, Vascular / Q000453:epidemiology; D005260:Female; D005852:Geriatric Psychiatry; D006801:Humans; D008297:Male; D015995:Prevalence; D013030:Spain / Q000453:epidemiology
keywords: Alzheimer's disease; Cerebrovascular disease; Comorbilidad cerebral; Dementia diagnosis accuracy; Dementia prevalence; Diagnóstico post-mortem; Enfermedad cerebrovascular; Enfermedad de Alzheimer; Fiabilidad diagnóstica en demencia; Mixed brain pathologies; Post-mortem diagnosis; Prevalencia de demencia