title: [Autologous Peripheral Blood Hematopoietic Stem Cell Transplantation for Treating Patient with Primary Cutaneous γΔ T Cell Lymphoma].
abstract: OBJECTIVE
  To investigate the clinical characteristics of primary cutaneous γΔ T cell lymphoma and its treatment methods.
  
  
  METHODS
  The clinical data and treatment process of one woman case of primary cutaneous γ Δ T cell lymphoma diagnosed in our department were analysed. The multiple subcutaneous nodules were the main clinical features, the diagnosis of primary cutaneous γΔ T cell lymphoma was comfired by skin biopsy pathology. The immunophenotypes of lymphocytes showed CD20-, CD3+, CD4-, CD8-, CD56+, TIA-1+, Ki-67+ (about 60%); plasma cells kappa+(part)/lambda predominate+(part); histocytes CD4+, CD68/PGM1+; βF1-, epstein-barr (EB) virus showed negative EBER in situ hybridization.
  
  
  RESULTS
  By means of the chemotherapy regimens containing L-Asparaginase, the complete remission (CR) was achieved. Then, the patients were given autologous hematopoietic stem cell transplantation. Neutrophils were implanted after 16 days, and platelet was implanted after 18 days. Now, the patient is still in remission.
  
  
  CONCLUSIONS
  primary cutaneous γΔ T cell lymphoma is rare and easy to be misdiagnosed. This disease is aggressive and its prognosis is poor. The large dose chemotherapy with L-asparaginase shows a certain curative efficacy, the autologous hematopoietic stem cells can prolong survival time of the patient.
authors.affiliation: Department of Hematology, Yijishan Hospital, Wannan Medical College, Wuhu 241000, Anhui Province, China.
authors.forename: Zhong-Ling
authors.initials: ZL
authors.lastname: Wei
authors.affiliation: Department of Hematology, Yijishan Hospital, Wannan Medical College, Wuhu 241000, Anhui Province, China.
authors.forename: Lai-Quan
authors.initials: LQ
authors.lastname: Huang
authors.affiliation: Department of Hematology, Yijishan Hospital, Wannan Medical College, Wuhu 241000, Anhui Province, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Dai
authors.affiliation: Department of Hematology, Yijishan Hospital, Wannan Medical College, Wuhu 241000, Anhui Province, China.
authors.forename: Gui-Ping
authors.initials: GP
authors.lastname: Su
authors.affiliation: Department of Hematology, Yijishan Hospital, Wannan Medical College, Wuhu 241000, Anhui Province, China.
authors.forename: Yi-Zhi
authors.initials: YZ
authors.lastname: Jiang
authors.affiliation: Department of Hematology, Yijishan Hospital, Wannan Medical College, Wuhu 241000, Anhui Province, China. E-mail: hdp_9713@163.com.
authors.forename: Dong-Ping
authors.initials: DP
authors.lastname: Huang
mesh_terms: D001215:Asparaginase / Q000627:therapeutic use; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D016130:Immunophenotyping; D016410:Lymphoma, T-Cell, Cutaneous / Q000628:therapy*; D012074:Remission Induction; D014182:Transplantation, Autologous
chemical_list: D001215:Asparaginase