title: Sentinel lymph node detection during radical prostatectomy for prostate cancer: current evidence and results of our experience.
abstract: OBJECTIVE
  A sentinel lymph node (SNL) is the primary landing zone of cancer cells that spreads through the lymphatic vessels. The rational of the detection of sentinel node (SLN) during radical prostatectomy (RP) for prostate cancer (PCa) is the removal of the first nodal stations to provide a restriction of the template of node dissection. A review of the outcomes of SNL detection during RP for PCa was performed.
  
  
  METHODS
  A systematic review of the literature was conducted, searching on PubMed and Web of Science, using the following keywords: lymph node dissection, prostatic neoplasm, sentinel node.
  
  
  RESULTS
  Twenty articles were selected and analyzed including over 2000 PCa patients. Although promising and technically feasible, many points remain to be clarified before clinical application can be recommended.
  
  
  CONCLUSIONS
  The technique of SNL detection is feasible and provides a higher sensitivity and detection rate than standard lymphadenectomy, especially for organ-confined tumors. Larger series and long-term follow-up data are mandatory to assess the oncologic effectiveness of the detection of SNL for PCa.
authors.affiliation:  Department of Urology, Maggiore della Carità Hospital, University of Eastern Piedmont, Novara - Italy.
authors.forename: Giansilvio
authors.initials: G
authors.lastname: Marchioro
authors.affiliation:  Department of Urology, Città della Salute e della Scienza Hospital, University of Torino, Torino - Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Gontero
authors.affiliation:  Department of Urology, Maggiore della Carità Hospital, University of Eastern Piedmont, Novara - Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: De Angelis
authors.affiliation:  Department of Urology, Maggiore della Carità Hospital, University of Eastern Piedmont, Novara - Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Volpe
authors.affiliation:  Department of Urology, Città della Salute e della Scienza Hospital, University of Torino, Torino - Italy.
authors.forename: Bruno
authors.initials: B
authors.lastname: Frea
authors.affiliation:  Department of Urology, Maggiore della Carità Hospital, University of Eastern Piedmont, Novara - Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Terrone
mesh_terms: D006801:Humans; D007430:Intraoperative Care / Q000379:methods*; D008197:Lymph Node Excision; D008297:Male; D011446:Prospective Studies; D011468:Prostatectomy / Q000379:methods*; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery*; D000071036:Sentinel Lymph Node / Q000473:pathology*