title: [The expression of VEGF-C in the condylar cartilage after anterior disc displacement and its clinical significance].
abstract: OBJECTIVE
  To investigate the expression and significance of vascular endothelial growth factor-C in the condylar cartilage after anterior disc displacement of temporomandibular joint.
  
  
  METHODS
  Sixty healthy adult Japanese rabbits were used in this study. Forty-eight rabbits were subjected to surgical anterior disc displacement in the right TMJs, every 12 rabbits were sacrificed 1, 2, 4, 8 weeks post-operation, 12 rabbits without operation were used as normal control.The gene expression and distribution of VEGF-C in condylar cartilage were studied by gene chip, real-time quantitative PCR and SP immunohistochemical methods. Paired t test was used for analysis with SPSS19.0 software package.
  
  
  RESULTS
  After anterior disc displacement, the expression of VEGF-C in the 2nd week reached to a minimum level, there was a significant difference (P<0.05), and increased in the 8th week. VEGF-C was expressed by cells of articular cartilage in the proliferative zone, hypertrophic zone and calcified cartilage zone. The expression in 1-week group was mainly found in the deep proliferative zone and hypertrophic zone, while the expression mainly found in the hypertrophic zone in 2-and 4-week group; calcified cartilage gradually enhanced, and there was significant difference (P<0.05) between 8-week group and control group.
  
  
  CONCLUSIONS
  VEGF-C gene transcription and expression may be involved in the remodeling of the condylar cartilage after anterior disc displacement.
authors.affiliation: School of Stomatology, Zhejiang Chinese Medical University. Hangzhou 310053, China. E-mail：852819264@qq.com.
authors.forename: Gao-li
authors.initials: GL
authors.lastname: Xu
authors.affiliation: School of Stomatology, Zhejiang Chinese Medical University. Hangzhou 310053, China.
authors.forename: Shu-hua
authors.initials: SH
authors.lastname: Wang
authors.affiliation: School of Stomatology, Zhejiang Chinese Medical University. Hangzhou 310053, China.
authors.forename: Qiu-tao
authors.initials: QT
authors.lastname: Shi
authors.affiliation: School of Stomatology, Zhejiang Chinese Medical University. Hangzhou 310053, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.affiliation: School of Stomatology, Zhejiang Chinese Medical University. Hangzhou 310053, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Yan
authors.affiliation: 2.Department of Stomatology, First hospital, Zhejiang University School of Medicine. Hangzhou 310003, Zhejiang Province, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Xu
authors.affiliation: School of Stomatology, Zhejiang Chinese Medical University. Hangzhou 310053, China.
authors.forename: Zhi-yuan
authors.initials: ZY
authors.lastname: Gu
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000378:metabolism*; D006984:Hypertrophy; D011817:Rabbits; D013704:Temporomandibular Joint / Q000378:metabolism*; D019224:Temporomandibular Joint Disc; D013705:Temporomandibular Joint Disorders; D042582:Vascular Endothelial Growth Factor C / Q000378:metabolism*
chemical_list: D042582:Vascular Endothelial Growth Factor C