title: Vascular endothelial growth factor polymorphisms are associated with osteosarcoma susceptibility.
abstract: Polymorphisms in the vascular endothelial growth factor (VEGF) gene may contribute to osteosarcoma risk, but the results of previous studies have been inconsistent and inconclusive. We conducted a meta-analysis to assess this association more accurately. Relevant studies were collected systemically from three online English databases. Crude odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the associations of three VEGF gene polymorphisms (+936C/T, -634 G/C, +1612 G/A) with osteosarcoma risk. Seven case-control studies involving 1,350 cases and 1,706 controls were selected for the meta-analysis. The pooled OR indicated that the VEGF +936C/T polymorphism was associated with increased risk of osteosarcoma in a Chinese population (T vs. C: OR = 1.26, 95% CI = 1.12-1.42, P < 0.01; TT vs. CC: OR = 1.70, 95% CI = 1.29-2.24, P < 0.01; CT + TT vs. CC: OR = 1.23, 95% CI = 1.06-1.44, P < 0.01; TT vs. CC + CT: OR = 1.61, 95% CI = 1.23-2.10, P < 0.01). A significant association was also found between the -634 G/C polymorphism and osteosarcoma risk (C vs. G: OR = 0.81, 95% CI = 0.69-0.96, P = 0.01; CC vs. GG: OR = 0.66, 95% CI = 0.48-0.90, P < 0.01; GC + CC vs. GG: OR = 0.80, 95% CI = 0.67-0.96, P = 0.02; CC vs. GG + GC: OR = 0.72, 95% CI = 0.60-0.86, P < 0.01). In sum, our meta-analysis suggests VEGF polymorphisms are associated with osteosarcoma susceptibility in the Chinese population. However, further studies that include different ethnicities and larger populations are needed.
authors.affiliation: Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Hu
authors.affiliation: Department of Stomatology, People's Hospital of New District Longhua Shenzhen, Shenzhen 518109, China.
authors.forename: Xin-Ya
authors.initials: XY
authors.lastname: Du
authors.affiliation: Department of Anesthesiology, Central Hospital of Shanghai Songjiang District, Shanghai 201600, China.
authors.forename: Ai-Ling
authors.initials: AL
authors.lastname: Zhan
authors.affiliation: Department of Neurology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Jiang
authors.affiliation: Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.|Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.
authors.forename: Yu-Ming
authors.initials: YM
authors.lastname: Niu
authors.affiliation: Jiangsu Key Laboratory of Oral Diseases, Department of Dental Implant, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing 210029, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Shen
mesh_terms: D044466:Asian People / Q000235:genetics*; D001859:Bone Neoplasms / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D020022:Genetic Predisposition to Disease; D006801:Humans; D012516:Osteosarcoma / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A
keywords: meta-analysis; osteosarcoma; polymorphism; vascular endothelial growth factor