title: [Survival effect after antiretroviral treatment initiating at different times on AIDS patients in Henan province, 2002-2014].
abstract: OBJECTIVE
  To study the survival effect of AIDS patients after the antiretroviral treatment that initiated at different times and to understand the factors associated with the survival time.
  
  
  METHODS
  Information on AIDS patients who started receiving the antiretroviral therapy during 2002-2014 was collected from the Chinese HIV/AIDS Integrated Control System in Henan province. According to the level of baseline immunology, all the participants were divided into earlier treatment group [Baseline CD4(+)T lymphocyte cell counts (CD4) between 350/μl and 500/μl] or conventional treatment group (Baseline CD4 cell counts≤350/μl). Data was analyzed with both Survival and Review methods.
  
  
  RESULTS
  A total number of 37 169 cases were selected, including 32 129 cases in the conventional treatment group and 5 040 cases in the earlier treatment group. Mortalities in the conventional treatment group and earlier treatment group were 4.3/100 person year and 1.8/100 person year, respectively. Data on the 11-year cumulative survival rate of both the conventional treatment group and earlier treatment group were 67.9% and 82.3%, respectively. By means of multi-variable analysis, we found that factors as gender, age, marital status, route of infection, number of symptoms, missed taking drugs in the past 7 days, degree of education at baseline of conventional treatment group etc. were associated with survival time of patients after the initiation of antiretroviral treatment (ART) (P<0.05) while factors as gender, age, marital status, ever missed taking drugs in the past 7 days at baseline etc. in the earlier treatment group were associated with the survival time of patients after the ART initiation (P<0.05).
  
  
  CONCLUSIONS
  Strategy including earlier initiation of antiretroviral treatment on AIDS patients who had met the treatment criteria and programs related to the improvement on adherence to medication, could prolong the survival time of AIDS patients, in Henan province.
authors.affiliation: STD/AIDS Prevention and Control Institute, Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China.
authors.forename: W J
authors.initials: WJ
authors.lastname: Yang
authors.forename: P Y
authors.initials: PY
authors.lastname: Fan
authors.forename: Y
authors.initials: Y
authors.lastname: Liang
authors.forename: Y G
authors.initials: YG
authors.lastname: Nie
authors.forename: Q
authors.initials: Q
authors.lastname: Zhu
authors.forename: N
authors.initials: N
authors.lastname: Li
authors.forename: D Y
authors.initials: DY
authors.lastname: Sun
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000163:Acquired Immunodeficiency Syndrome; D044966:Anti-Retroviral Agents; D044466:Asian People; D018791:CD4 Lymphocyte Count; D006801:Humans; D017533:Marital Status; D015996:Survival Rate
chemical_list: D044966:Anti-Retroviral Agents