title: Hibernation, Hypothermia and a Possible Therapeutic "Shifted Homeostasis" Induced by Central Activation of A1 Adenosine Receptor (A1AR).
abstract: The positive outcome that hypothermia contributes to brain and cardiac protection following ischemia has stimulated research in the development of pharmacological approaches to induce a hypothermic/hypometabolic state. Pharmacological manipulation of central autonomic thermoregulatory circuits could represent a potential target for the induction of a hypothermic state. Here we present a brief description of the CNS thermoregulatory centers and how the manipulation of these circuits can be useful in the treatment of pathological conditions such as stroke or brain hemorrhage.
authors.forename: Domenico
authors.initials: D
authors.lastname: Tupone
authors.forename: Justin S
authors.initials: JS
authors.lastname: Cetas
authors.forename: Shaun F
authors.initials: SF
authors.lastname: Morrison
mesh_terms: D000818:Animals; D001833:Body Temperature Regulation / Q000502:physiology*; D006706:Homeostasis; D006801:Humans; D007036:Hypothermia, Induced; D043682:Receptor, Adenosine A1 / Q000378:metabolism / Q000502:physiology*; D020521:Stroke / Q000503:physiopathology / Q000628:therapy; D013345:Subarachnoid Hemorrhage / Q000503:physiopathology / Q000628:therapy
chemical_list: D043682:Receptor, Adenosine A1