title: Therapeutic effects of ellagic acid on L-arginin ınduced acute pancreatitis.
abstract: OBJECTIVE
  To investigate the therapeutic effects of ellagic acid on L-arginin ınduced acute pancreatitis in rats.
  
  
  METHODS
  Thirty-two were split into four groups. Group 1 (control) rats were performed only laparotomy, no drugs were administered. Group 2 (control+EA) rats were administered 85mg/kg EA orally. Rats were sacrificed by cardiac puncture 24 hours after the administration. Group3 (AP) 24 hours after intraperitoneal L-arginine administration, rats were sacrificed by cardiac puncture. Group 4 (EA)-(AP): 85mg/kg EA was administered orally after the L-arginine administration. 24 hours later, rats were sacrificed by cardiac puncture. Serum TNF-α, IL-1β, IL-6, total oxidative status (TOS), total antioxidant capacity (TAC), amylase levels were determined in all groups.
  
  
  RESULTS
  Group 3 (AP) rats showed significantly raised TOS level as compared to Group1 (control) rats (p<0.001). Following the EA therapy, a decrease in TOS was observed in Group 4 (AP+EA). TAC levels were significantly raised in the Group 4 (AP+EA) compared to the Group 3 (AP) (p=0.003). Group 3 (AP) showed significantly increased TNF-α, IL-1β and IL-6 serum levels as compared to Group 4 (AP+EA). Histopathological changes were supported our result.
  
  
  CONCLUSIONS
  The healing effects of ellagic acid on inflammatory and oxidative stress were confirmed by histopathological and biochemical evaluations of the pancreatic tissue.
authors.affiliation: MD, Department of General Surgery, Diyarbakır Gazi Yaşargil Education and Research Hospital, Turkey. Intellectual and scientific content of the study, design the protocol, surgical procedures, acquisition and interpretation of data, statistical analysis, manuscript writing.
authors.forename: Edip Erdal
authors.initials: EE
authors.lastname: Yılmaz
authors.affiliation: Assistant Professor, Department of General Surgery, Faculty of Medicine, Dicle University, Turkey. Design the protocol, surgical procedures, acquisition and interpretation of data, statistical analysis, manuscript writing.
authors.forename: Zübeyir
authors.initials: Z
authors.lastname: Bozdağ
authors.affiliation: Assistant Professor, Department of Pathology, Faculty of Medicine, Dicle University, Turkey. Surgical procedures, acquisition of data.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Ibiloğlu
authors.affiliation: Assosciate Professor, Department of General Surgery, Faculty of Medicine, Dicle University, Turkey. Surgical procedures, acquisition and interpretation of data, statistical analysis.
authors.forename: Zülfü
authors.initials: Z
authors.lastname: Arıkanoğlu
authors.affiliation: Assistant Professor, Department of Physiology, Faculty of Medicine, Zirve University, Turkey. Surgical procedures, statistical analysis.
authors.forename: Ümit Can
authors.initials: ÜC
authors.lastname: Yazgan
authors.affiliation: Assistant Professor, Department of Biochemistry, Faculty of Medicine, Dicle University, Turkey. Surgical procedures, acquisition and interpretation of data, statistical analysis.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Kaplan
authors.affiliation: Assosciate Professor, Department of General Surgery, Faculty of Medicine, Dicle University, Turkey. Statistical analysis, acquisition and interpretation of data, manuscript writing, critical revision.
authors.forename: Metehan
authors.initials: M
authors.lastname: Gümüş
authors.affiliation: Professor, Head, Department of General Surgery, Faculty of Medicine, Ataturk University, Turkey. Manuscript writing, critical revision.
authors.forename: Sabri Selçuk
authors.initials: SS
authors.lastname: Atamanalp
mesh_terms: D000208:Acute Disease; D000681:Amylases / Q000097:blood / Q000187:drug effects; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D001120:Arginine; D004610:Ellagic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D053583:Interleukin-1beta / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D010195:Pancreatitis / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D011897:Random Allocation; D017207:Rats, Sprague-Dawley; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D053583:Interleukin-1beta; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D004610:Ellagic Acid; D001120:Arginine; D000681:Amylases