title: Central Skull Base Osteomyelitis: Diagnostic Dilemmas and Management Issues.
abstract: The aim of this study is to describe the clinical presentation of central skull base osteomyelitis and to discuss the classical imaging findings and various diagnostic and therapeutic challenges faced in the management of this condition. This is a retrospective analysis of inpatient case records, carried out in a multidisciplinary tertiary care hospital. The study subjects included five elderly diabetic patients presenting to the ENT surgeon or neurologist with headache followed by multiple cranial nerve paralysis with no temporal bone involvement in four patients and a past history of otitis externa in one patient. These patients were diagnosed to have an infective pathology of the central skull base detected by imaging and confirmed by biopsy in three. All were treated successfully with antibiotics administered for an average period of 6 weeks. Three patients followed up over 4 years and showed no relapses. One succumbed to other medical co morbidities after 8 months and one diagnosed a month prior is still under follow up. A symptom complex of headache and cranial neuropathies usually raises the suspicion of malignancy. Central skull base osteomyelitis, a relatively uncommon pathology, must also be considered as a possible differential diagnosis despite absence of a definite septic focus. Imaging studies showing bony destruction and adjacent soft tissue involvement should raise the suspicion of this clinical entity. Malignancy needs to be ruled out by biopsy. Early diagnosis and prompt initiation of antibiotics administered for an adequate duration is of paramount importance in successfully treating these patients. A multidisciplinary approach is needed for a successful outcome.
authors.affiliation: Department of ENT, Bombay Hospital and MRC, Mumbai, India ; Suman Apartments, 3rd floor, 16 B Naushir Bharucha Road, Tardeo, Mumbai, 400 007 India.
authors.forename: Sujata N
authors.initials: SN
authors.lastname: Muranjan
authors.affiliation: Department of Neurology, Bombay Hospital and MRC, Mumbai, India.
authors.forename: Satish V
authors.initials: SV
authors.lastname: Khadilkar
authors.affiliation: Department of General Medicine, Bombay Hospital and MRC, Mumbai, India.
authors.forename: Sanjay C
authors.initials: SC
authors.lastname: Wagle
authors.affiliation: Department of Imaging, Bombay Hospital and MRC, Mumbai, India.
authors.forename: Sunila T
authors.initials: ST
authors.lastname: Jaggi
keywords: Central skullbase; Clivus; Cranial neuropathies; Osteomyelitis