title: The Immune Landscape in Nonalcoholic Steatohepatitis.
abstract: The liver lies at the intersection of multiple metabolic pathways and consequently plays a central role in lipid metabolism. Pathological disturbances in hepatic lipid metabolism are characteristic of chronic metabolic diseases, such as obesity-mediated insulin resistance, which can result in nonalcoholic fatty liver disease (NAFLD). Tissue damage induced in NAFLD activates and recruits liver-resident and non-resident immune cells, resulting in nonalcoholic steatohepatitis (NASH). Importantly, NASH is associated with an increased risk of significant clinical sequelae such as cirrhosis, cardiovascular diseases, and malignancies. In this review, we describe the immunopathogenesis of NASH by defining the known functions of immune cells in the progression and resolution of disease.
authors.affiliation: Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908, USA.; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia 22908, USA.
authors.forename: Sowmya
authors.initials: S
authors.lastname: Narayanan
authors.affiliation: Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908, USA.
authors.forename: Fionna A
authors.initials: FA
authors.lastname: Surette
authors.affiliation: Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908, USA.; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia 22908, USA.
authors.forename: Young S
authors.initials: YS
authors.lastname: Hahn
keywords: Fatty liver; Immunity; Liver