title: Anti-obesity and anti-diabetic effects of a standardized potato extract inob/obmice.
abstract: The potato (Solanum tuberosum) has been cultivated globally for food for millenia. Potato contains proteinase inhibitor II, which catalyzes the release of cholecystokinin (CCK), leading to delayed gastric emptying in humans. The present study investigated the anti-obesity effects of Slendesta™ Potato Extract (SLD), a standardized potato extract containing 5% proteinase inhibitor II, in theob/obobese mice. Three doses of SLD (50, 150 or 300 mg/kg) were orally administered toob/obmice once a day for 28 days, whereas control mice were administered distilled water. Four weeks after SLD treatment, the changes in body weight, food consumption, epididymal fat weight, serum chemistry, insulin, leptin and adiponectin contents, and fat histopathology were determined and compared withob/obmice treated with 750 mg/kg conjugate linoleic acid. As a result of SLD treatment in the obese mice, body weight, food consumption, epididymal fat, serum biochemistry, histomorphological changes of fat and pancreas were significantly and dose-dependently decreased compared withob/obcontrol mice. These obesity and type 2 diabetes associated alterations were significantly inhibited after SLD treatment for 28 days. Thus, the present results indicate that SLD has potential as an alternative therapeutic agent for obesity.
authors.affiliation: Department of Anatomy and Histology, College of Oriental Medicine, Daegu Haany University, Gyeongsan-Si, Gyeongsanbuk-Do 712-715, Republic of Korea.
authors.forename: Sae Kwang
authors.initials: SK
authors.lastname: Ku
authors.affiliation: Aribio, Inc., Byeoksan Digital Valley, Suite 1004, Yeongdeungpo-Gu, Seoul 150-095, Republic of Korea.
authors.forename: Soo Hyun
authors.initials: SH
authors.lastname: Sung
authors.affiliation: EU Biotech Development Co., London W1D 2EU, UK.
authors.forename: Jai Jun
authors.initials: JJ
authors.lastname: Choung
authors.affiliation: Division of Bioindustry, College of Medical and Life Sciences, Silla University, Sasang-Gu, Busan 617-736, Republic of Korea.
authors.forename: Jae-Suk
authors.initials: JS
authors.lastname: Choi
authors.affiliation: Department of Natural Medicine Resources, Semyung University, Jecheon-Si, Chungcheongbuk-Do 390-711, Republic of Korea.
authors.forename: Yong Kook
authors.initials: YK
authors.lastname: Shin
authors.affiliation: Aribio, Inc., Byeoksan Digital Valley, Suite 1004, Yeongdeungpo-Gu, Seoul 150-095, Republic of Korea.
authors.forename: Joo Wan
authors.initials: JW
authors.lastname: Kim
keywords: ob/ob mouse; obesity; potato extract; potato proteinase inhibitor II