title: Maintenance of B cells during chronic murine Trypanosoma brucei gambiense infection.
abstract: African trypanosomosis is a debilitating parasitic disease occurring in large parts of sub-Saharan Africa. Trypanosoma brucei gambiense accounts for 98% of the reported HAT infections and causes a chronic, gradually progressing disease. Multiple experimental murine models for trypanosomosis have demonstrated inflammation-dependent apoptosis of splenic follicular B (FoB) cells and the destruction of B-cell memory against previously encountered pathogens. Here, we report that during murine infection with a chronic T. b. gambiense field isolate, FoB cells are retained. This coincided with reduced levels of IFN-γ and TNF-α during the acute phase of the infection. This result suggests that in chronic infections with low virulent parasites, less inflammation is elicited and consequently no FoB cell destruction occurs.
authors.affiliation: Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium.|Structural Biology Research Center, Vlaams Instituut voor Biotechnologie (VIB), Brussels, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Cnops
authors.affiliation: Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium.|Structural Biology Research Center, Vlaams Instituut voor Biotechnologie (VIB), Brussels, Belgium.
authors.forename: F
authors.initials: F
authors.lastname: Kauffmann
authors.affiliation: Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium.|Structural Biology Research Center, Vlaams Instituut voor Biotechnologie (VIB), Brussels, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: De Trez
authors.affiliation: UMR 5234, Centre National de Recherche Scientifique, IFR66, Université Bordeaux 2, Bordeaux, France.
authors.forename: T
authors.initials: T
authors.lastname: Baltz
authors.affiliation: Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium.|VIB Laboratory of Myeloid Cell Immunology, Brussels, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Keirsse
authors.affiliation: Ghent University Global Campus, Incheon, Korea.
authors.forename: M
authors.initials: M
authors.lastname: Radwanska
authors.affiliation: Unité de Recherche en Biologie des Microorganismes, Laboratoire d'Immunologie et de Microbiologie, Université de Namur, Namur, Belgium.|Laboratoire de Parasitologie, Université Libre de Bruxelles, Campus Erasme, Brussels, Belgium.
authors.forename: E
authors.initials: E
authors.lastname: Muraille
authors.affiliation: Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium. stemagez@vub.ac.be.|Structural Biology Research Center, Vlaams Instituut voor Biotechnologie (VIB), Brussels, Belgium. stemagez@vub.ac.be.|Ghent University Global Campus, Incheon, Korea. stemagez@vub.ac.be.
authors.forename: S
authors.initials: S
authors.lastname: Magez
mesh_terms: D000818:Animals; D017209:Apoptosis; D001402:B-Lymphocytes / Q000276:immunology*; D002908:Chronic Disease; D005260:Female; D007371:Interferon-gamma / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000276:immunology; D014347:Trypanosoma brucei gambiense / Q000276:immunology*; D014353:Trypanosomiasis, African / Q000276:immunology* / Q000469:parasitology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: C000611649:IFNG protein, mouse; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma
keywords: B lymphocyte; Trypanosoma spp.; inflammation; trypanosomiasis