title: Fish Oil Supplementation Enhances Pulmonary Strength and Endurance in Women Undergoing Chemotherapy.
abstract: We investigated the effect of fish oil (FO) supplementation, at 4 g/day, on the respiratory performance and blood lipid profile of 32 patients with breast cancer at the beginning of chemotherapy. They were randomized into two groups: control (C) and FO supplemented (S). Both groups underwent three respiratory evaluations and blood harvest (before chemotherapy-Day 0, and 30 and 60 days after supplementation). The S group showed a significant increase in the maximal inspiratory and expiratory pressure (P ≤ 0.05 vs. Day 0) and in the maximum voluntary ventilation (P ≤ 0.05). In the treadmill 6-min-walk test, the S group had a significant increase in the walked distance (P ≤ 0.05). Blood lactate concentration was significantly lower in the S group after 60 days, at rest, when compared to C (P ≤ 0.05). Plasma high-density lipoprotein (HDL) cholesterol concentration remained the same after 60 days of supplementation, while in the C group, it decreased significantly (P ≤ 0.05 Day 0 vs. Day 60). Triacylglycerol (TAG) plasma concentration in the S group was lower when compared to the C group (P ≤ 0.05 Day 60S vs. Day 60). Supplementation with FO caused improvement in the respiratory muscle strength and endurance, ameliorated functional performance, and kept TAG, HDL cholesterol, and lactate plasma concentration at normal levels.
authors.affiliation: a Department of Physiology , Biological Science Building, Cell Metabolism Laboratory, Federal University of Parana , Curitiba , Brazil.
authors.forename: Doris Naoko
authors.initials: DN
authors.lastname: Suzumura
authors.affiliation: a Department of Physiology , Biological Science Building, Cell Metabolism Laboratory, Federal University of Parana , Curitiba , Brazil.
authors.forename: Juliana Carvalho
authors.initials: JC
authors.lastname: Schleder
authors.affiliation: a Department of Physiology , Biological Science Building, Cell Metabolism Laboratory, Federal University of Parana , Curitiba , Brazil.
authors.forename: Marcia Helena
authors.initials: MH
authors.lastname: Appel
authors.affiliation: b Department of Cell Biology , Biological Science Building, Federal University of Parana , Curitiba , Brazil.
authors.forename: Katya
authors.initials: K
authors.lastname: Naliwaiko
authors.affiliation: a Department of Physiology , Biological Science Building, Cell Metabolism Laboratory, Federal University of Parana , Curitiba , Brazil.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Tanhoffer
authors.affiliation: a Department of Physiology , Biological Science Building, Cell Metabolism Laboratory, Federal University of Parana , Curitiba , Brazil.
authors.forename: Luiz Claudio
authors.initials: LC
authors.lastname: Fernandes
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001938:Brazil; D001943:Breast Neoplasms / Q000097:blood / Q000178:diet therapy / Q000188:drug therapy* / Q000601:surgery; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D008076:Cholesterol, HDL / Q000097:blood; D019587:Dietary Supplements / Q000009:adverse effects; D005080:Exercise Test; D005260:Female; D005395:Fish Oils / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D019344:Lactic Acid / Q000097:blood; D008168:Lung / Q000187:drug effects* / Q000503:physiopathology; D008875:Middle Aged; D053580:Muscle Strength / Q000187:drug effects; D010807:Physical Endurance / Q000187:drug effects*; D011182:Postoperative Care; D011183:Postoperative Complications / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control; D015203:Reproducibility of Results; D012131:Respiratory Insufficiency / Q000139:chemically induced / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D012132:Respiratory Muscles / Q000187:drug effects / Q000503:physiopathology; D014280:Triglycerides / Q000097:blood
chemical_list: D000970:Antineoplastic Agents; D008076:Cholesterol, HDL; D005395:Fish Oils; D014280:Triglycerides; D019344:Lactic Acid