title: Whole-brain analytic measures of network communication reveal increased structure-function correlation in right temporal lobe epilepsy.
abstract: The in vivo structure-function relationship is key to understanding brain network reorganization due to pathologies. This relationship is likely to be particularly complex in brain network diseases such as temporal lobe epilepsy, in which disturbed large-scale systems are involved in both transient electrical events and long-lasting functional and structural impairments. Herein, we estimated this relationship by analyzing the correlation between structural connectivity and functional connectivity in terms of analytical network communication parameters. As such, we targeted the gradual topological structure-function reorganization caused by the pathology not only at the whole brain scale but also both in core and peripheral regions of the brain. We acquired diffusion (dMRI) and resting-state fMRI (rsfMRI) data in seven right-lateralized TLE (rTLE) patients and fourteen healthy controls and analyzed the structure-function relationship by using analytical network communication metrics derived from the structural connectome. In rTLE patients, we found a widespread hypercorrelated functional network. Network communication analysis revealed greater unspecific branching of the shortest path (search information) in the structural connectome and a higher global correlation between the structural and functional connectivity for the patient group. We also found evidence for a preserved structural rich-club in the patient group. In sum, global augmentation of structure-function correlation might be linked to a smaller functional repertoire in rTLE patients, while sparing the central core of the brain which may represent a pathway that facilitates the spread of seizures.
authors.affiliation: Aix-Marseille Université, CNRS, CRMBM UMR 7339, 13385 Marseille, France; APHM, Hôpitaux de la Timone, Pôle d'imagerie Médicale, CEMEREM, 13005 Marseille, France; Aix-Marseille Université, Institut de Neurosciences des Systèmes, 13385 Marseille, France; INSERM, UMR_S 1106, 13385 Marseille, France. Electronic address: jonathan.wirsich@univ-amu.fr.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Wirsich
authors.affiliation: Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Sydney, NSW, Australia; School of Psychiatry, University of New South Wales, Sydney, NSW 2052, Australia; Systems Neuroscience Group, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, QLD 4006, Australia. Electronic address: alistairperry123@gmail.com.
authors.forename: Alistair
authors.initials: A
authors.lastname: Perry
authors.affiliation: Aix-Marseille Université, CNRS, CRMBM UMR 7339, 13385 Marseille, France; APHM, Hôpitaux de la Timone, Pôle d'imagerie Médicale, CEMEREM, 13005 Marseille, France. Electronic address: ben.ridley@univ-amu.fr.
authors.forename: Ben
authors.initials: B
authors.lastname: Ridley
authors.affiliation: Aix-Marseille Université, Institut de Neurosciences des Systèmes, 13385 Marseille, France; INSERM, UMR_S 1106, 13385 Marseille, France. Electronic address: timothee.proix@gmail.com.
authors.forename: Timothée
authors.initials: T
authors.lastname: Proix
authors.affiliation: Aix-Marseille Université, Institut de Neurosciences des Systèmes, 13385 Marseille, France; INSERM, UMR_S 1106, 13385 Marseille, France. Electronic address: mathieu.golos@univ-amu.fr.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Golos
authors.affiliation: Aix-Marseille Université, Institut de Neurosciences des Systèmes, 13385 Marseille, France; INSERM, UMR_S 1106, 13385 Marseille, France. Electronic address: christian.benar@univ-amu.fr.
authors.forename: Christian
authors.initials: C
authors.lastname: Bénar
authors.affiliation: Aix-Marseille Université, CNRS, CRMBM UMR 7339, 13385 Marseille, France; APHM, Hôpitaux de la Timone, Pôle d'imagerie Médicale, CEMEREM, 13005 Marseille, France. Electronic address: jean-philippe.ranjeva@univ-amu.fr.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Ranjeva
authors.affiliation: Aix-Marseille Université, Institut de Neurosciences des Systèmes, 13385 Marseille, France; INSERM, UMR_S 1106, 13385 Marseille, France; APHM, Hôpitaux de la Timone, Pôle de Neurosciences Cliniques, Service de Neurophysiologie Clinique, 13005 Marseille, France. Electronic address: fabrice.bartolomei@ap-hm.fr.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Bartolomei
authors.affiliation: School of Psychiatry, University of New South Wales, Sydney, NSW 2052, Australia; Systems Neuroscience Group, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, QLD 4006, Australia; Metro North Mental Health Services, Brisbane, QLD 4006, Australia. Electronic address: mjbreaks@gmail.com.
authors.forename: Michael
authors.initials: M
authors.lastname: Breakspear
authors.affiliation: Aix-Marseille Université, Institut de Neurosciences des Systèmes, 13385 Marseille, France; INSERM, UMR_S 1106, 13385 Marseille, France. Electronic address: viktor.jirsa@univ-amu.fr.
authors.forename: Viktor
authors.initials: V
authors.lastname: Jirsa
authors.affiliation: Aix-Marseille Université, CNRS, CRMBM UMR 7339, 13385 Marseille, France; APHM, Hôpitaux de la Timone, Pôle d'imagerie Médicale, CEMEREM, 13005 Marseille, France. Electronic address: maxime.guye@univ-amu.fr.
authors.forename: Maxime
authors.initials: M
authors.lastname: Guye
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D001931:Brain Mapping; D063132:Connectome; D038524:Diffusion Magnetic Resonance Imaging; D004833:Epilepsy, Temporal Lobe / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D010100:Oxygen / Q000097:blood; D055815:Young Adult
chemical_list: D010100:Oxygen
keywords: CSD, constrained spherical deconvolution; CSF, cerebrospinal fluid; FA, fractional anisotropy; FCA, analytic functional connectivity; FCD, functional connectivity dynamics; FOD, fiber orientation distribution; Functional connectivity; NBS, network based statistics; Network based statistics; Network communication; Rich club; Structural connectivity; Temporal lobe epilepsy; dMRI, diffusion magnetic resonance imaging; rTLE, right temporal lobe epilepsy; rsfMRI, resting state functional magnetic resonance imaging