title: Is Gianotti-Crosti Syndrome Associated with Atopy? A Case-Control Study and a Postulation on the Intrinsic Host Factors in Gianotti-Crosti Syndrome.
abstract: OBJECTIVE
  To investigate whether Gianotti-Crosti syndrome (GCS) in children is associated with atopy.
  
  
  METHODS
  The setting was two outpatient clinic. Diagnoses of asthma and atopic dermatitis (AD) were made according to internationally accepted diagnostic criteria. Allergic rhinitis, atopic urticaria, and allergic conjunctivitis were diagnosed clinically. Participants were children with GCS diagnosed over the previous 5 years. For any child with GCS, we extracted the record of the subsequent age and sex pair-matched child seen for problems unrelated to the skin as controls.
  
  
  RESULTS
  We retrieved the records of 37 pairs of study and control subjects; 28 (76%) children with GCS and 9 (24%) controls had AD (risk ratio [RR] = 3.11[95% confidence interval {CI} 1.73, 5.73]), 31 (84%) children with GCS and 19 (51%) controls had at least one atopic condition (RR = 1.63 [95% CI 1.13, 2.18]) and 11 (30%) children with GCS and 2 (5%) controls had at least three atopic conditions (RR = 5.50 [95% CI 1.29, 35.35]).
  
  
  CONCLUSIONS
  GCS is significantly associated with AD and the presence of atopic conditions.
authors.affiliation: Jockey Club School of Public Health and Primary Care, Chinese University of Hong Kong and Prince of Wales Hospital, Shatin, Hong Kong. antonio.chuh@yahoo.com.hk.
authors.forename: Antonio
authors.initials: A
authors.lastname: Chuh
authors.affiliation: Skin Diseases Center, Nashik, India.
authors.forename: Vijay
authors.initials: V
authors.lastname: Zawar
authors.affiliation: Jockey Club School of Public Health and Primary Care, Chinese University of Hong Kong and Prince of Wales Hospital, Shatin, Hong Kong.
authors.forename: Albert
authors.initials: A
authors.lastname: Lee
authors.affiliation: Department of Dermatology, College of Medicine, Mayo Clinic, Rochester, Minnesota.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Sciallis
mesh_terms: D000169:Acrodermatitis / Q000453:epidemiology* / Q000276:immunology*; D017677:Age Distribution; D000554:Ambulatory Care Facilities; D001249:Asthma / Q000453:epidemiology / Q000276:immunology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D016001:Confidence Intervals; D003876:Dermatitis, Atopic / Q000453:epidemiology / Q000276:immunology; D005260:Female; D006784:Hospitals, Teaching; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology* / Q000276:immunology*; D007223:Infant; D008297:Male; D015995:Prevalence; D011379:Prognosis; D018570:Risk Assessment; D012720:Severity of Illness Index; D017678:Sex Distribution