title: A class of sulfonamides as carbonic anhydrase I and II inhibitors.
abstract: Four groups of novel sulfonamide derivatives: (i) acetoxybenzamide, (ii) triacetoxybenzamide, (iii) hydroxybenzamide and (iv) trihydroxybenzamide, all having thiazole, pyrimidine, pyridine, isoxazole and thiadiazole moieties were prepared and their inhibitory effects were studied on two metalloenzymes, i.e. carbonic anhydrase isozymes (hCA I and II), purified from human erythrocyte cells by Sepharose-4B-l-tyrosine-sulfanilamide affinity chromatography. These enzymes are present in almost all living organisms to catalyse the synthesis of bicarbonate ion (HCO3-) from carbon dioxide and water. The sulfonamide derivatives were found to be active against hCA I and II in the range of 2.62-136.54 and 5.74-210.58 nM, respectively.
authors.affiliation: a Chemistry Group Laboratories, TUBITAK UME , Gebze , Turkey.|b Department of Organic Chemistry , Faculty of Science, Istanbul Technical University , Istanbul , Turkey.
authors.forename: Taner
authors.initials: T
authors.lastname: Gokcen
authors.affiliation: c Department of Chemistry , Faculty of Science, Atatürk University , Erzurum , Turkey , and.|d Fetal Programming of Diseases Research Chair, Zoology Department, College of Science, King Saud University , Riyadh , Saudi Arabia.
authors.forename: Ilhami
authors.initials: I
authors.lastname: Gulcin
authors.affiliation: a Chemistry Group Laboratories, TUBITAK UME , Gebze , Turkey.|b Department of Organic Chemistry , Faculty of Science, Istanbul Technical University , Istanbul , Turkey.
authors.forename: Turan
authors.initials: T
authors.lastname: Ozturk
authors.affiliation: a Chemistry Group Laboratories, TUBITAK UME , Gebze , Turkey.
authors.forename: Ahmet C
authors.initials: AC
authors.lastname: Goren
mesh_terms: D024401:Carbonic Anhydrase I / Q000037:antagonists & inhibitors* / Q000378:metabolism; D024402:Carbonic Anhydrase II / Q000037:antagonists & inhibitors* / Q000378:metabolism; D002257:Carbonic Anhydrase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D002257:Carbonic Anhydrase Inhibitors; D013449:Sulfonamides; D024401:Carbonic Anhydrase I; D024402:Carbonic Anhydrase II
keywords: Enzyme inhibition; gallic acid; p-hydroxybenzoic acid