title: Fat, Stem Cells, and Platelet-Rich Plasma.
abstract: The ideal filler for aesthetic surgery is inexpensive and easy to obtain, natural in appearance and texture, immunologically compatible, and long lasting without risk of infection. By most metrics, autologous fat grafts meet these criteria perfectly. Although facial fat grafting is now a commonly accepted surgical procedure, there has been a wave of activity applying stem cells and platelet-rich plasma (PRP) therapies to aesthetic practice. This article addresses technical considerations in the use of autologous fat transfer for facial rejuvenation, and also explores the current evidence for these stem cell and PRP therapies in aesthetic practice.
authors.affiliation: Department of Plastic Surgery, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA.
authors.forename: Isaac B
authors.initials: IB
authors.lastname: James
authors.affiliation: Department of Plastic Surgery, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA; Department of Plastic Surgery, New York University Langone Medical Center, 44 Hudson Street, New York, NY 10013, USA; Private Practice, Tribeca Plastic Surgery, New York, NY.
authors.forename: Sydney R
authors.initials: SR
authors.lastname: Coleman
authors.affiliation: Department of Plastic Surgery, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA; Department of Bioengineering, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15261, USA; McGowan Institute for Regenerative Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA. Electronic address: rubipj@UPMC.EDU.
authors.forename: J Peter
authors.initials: JP
authors.lastname: Rubin
mesh_terms: D000273:Adipose Tissue / Q000637:transplantation*; D003357:Cosmetic Techniques; D000067548:Dermal Fillers; D005145:Face / Q000601:surgery*; D006801:Humans; D053657:Platelet-Rich Plasma; D044968:Regenerative Medicine; D012060:Rejuvenation; D015595:Skin Aging; D033581:Stem Cell Transplantation
chemical_list: D000067548:Dermal Fillers
keywords: Adipose-derived stem cells; Autologous fat; Coleman technique; Facial augmentation; Facial rejuvenation; Fat; Fat grafting; Lipoaspirate; PRP; Platelet-rich plasma; Regenerative medicine; Stem cells; Stromal vascular fraction; Structural fat grafting