title: Synthesis and Bioactivity of (R)-Ricinoleic Acid Derivatives: A Review.
abstract: (R)-Ricinoleic acid (RA) [(12R,9Z)-hydroxyoctadecenoic acid], the main compound of castor seed oil, because of its unusual structure readily undergoes multi-directional chemical and biochemical transformations to produce derivatives with the retained carbon skeleton or with its degradation. Many of these are of high biological activity, as documented by an in vitro study, and possess therapeutic potential. This review article provides an overview of the recent developments in the area of synthesis of RA based compounds with anticancer and antimicrobial activities. Moreover, the antiinflammatory and analgesic properties of some ricinoleic acid derivatives are also highlighted.
authors.forename: Sylwia
authors.initials: S
authors.lastname: Pabiś
authors.affiliation: Institute of General Food Chemistry, Faculty of Biotechnology and Food Science, Lodz University of Technology; ul. Stefanowskiego 4/10, 90-924 Lodz, Poland. jozef.kula@p.lodz.pl.
authors.forename: Józef
authors.initials: J
authors.lastname: Kula
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D002368:Castor Oil / Q000737:chemistry; D006801:Humans; D011091:Polyesters / Q000737:chemistry; D012277:Ricinoleic Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D012545:Schiff Bases / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects; D013237:Stereoisomerism
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D011091:Polyesters; D012277:Ricinoleic Acids; D012545:Schiff Bases; D002368:Castor Oil