title: High-Grade Neuroendocrine Carcinoma of the Breast With Focal Squamous Differentiation.
abstract: Primary neuroendocrine carcinoma of the breast is a rare tumor that comprises less than 1% of breast carcinomas, with most patients being in the sixth or seventh decade of their life. In this article, the authors present the case report of a 42-year-old woman with a rapidly growing tumor in her right breast. After clinical staging by physical examination, breast imaging, and thoracoabdominal computed tomography the patient underwent breast-conserving surgery. The histologic results showed a unique type of high-grade, predominantly large-cell neuroendocrine carcinoma with focal abrupt squamous differentiation. The authors also discuss the clinical and morphological characteristics of the tumor as well as treatment options.
authors.affiliation: Alpha Medical Pathology Ltd, Bratislava, Slovakia.
authors.forename: Iveta
authors.initials: I
authors.lastname: Mečiarová
authors.affiliation: Comenius University of Bratislava, Faculty of Medicine, Bratislava, Slovakia.|National Cancer Institute, Bratislava, Slovakia.
authors.forename: Michaela
authors.initials: M
authors.lastname: Sojáková
authors.affiliation: Comenius University of Bratislava, Faculty of Medicine, Bratislava, Slovakia.|National Cancer Institute, Bratislava, Slovakia.
authors.forename: Michal
authors.initials: M
authors.lastname: Mego
authors.affiliation: Comenius University of Bratislava, Faculty of Medicine, Bratislava, Slovakia.|National Cancer Institute, Bratislava, Slovakia.
authors.forename: Jozef
authors.initials: J
authors.lastname: Mardiak
authors.affiliation: Comenius University of Bratislava, Faculty of Medicine, Bratislava, Slovakia kpohlodek@gmail.com.
authors.forename: Kamil
authors.initials: K
authors.lastname: Pohlodek
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000175:diagnosis / Q000473:pathology*; D018278:Carcinoma, Neuroendocrine / Q000175:diagnosis / Q000473:pathology*; D002454:Cell Differentiation; D018450:Disease Progression; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D060787:Neoplasm Grading
chemical_list: D014408:Biomarkers, Tumor
keywords: breast cancer; diagnosis; histopathology; neuroendocrine tumors