title: Effects of Rhus tripartitum fruit extract on CCl4-induced hepatotoxicity and cisplatin-induced nephrotoxicity in rats.
abstract: Rhus tripartitum D.C., Anacardiaceae, has traditionally been used in Tunisia against many illnesses. The present study investigates, for the first time, the protective effects of the methanol extract of Rhus tripartitum fruit (MERT) against CCl4-induced hepatotoxicity and cisplatin-induced nephrotoxicty in Wistar rats. ALT, AST, LDH, GGT, creatinin, urea, and uric acid levels were studied. The changes in antioxidant parameters such as malondialdehyde (MDA) and protein carbonyl contents were also determined. The increased levels of MDA (30.97 and 11.50 nmol MDA/mg protein in liver and kidney, respectively) and protein carbonyls (13.4 and 17.95 nmol/mg protein in liver and kidney, respectively) were attenuated by MERT pretreatment (19.35 and 6.1 nmol MDA/mg protein and 9.15 and 12 nmol/mg protein in liver and kidney, respectively). The MERT pretreatment significantly reduced the increased biochemical parameters of liver and kidney caused by CCl4 and cisplatin treatment. The histopathologic observation showed that MERT pretreatment restores the altered tissues. The observed results could be due to the high phenolic content and to MERT's important antioxidant potential. This study supports the hepatoprotective and nephroprotective effects of R. tripartitum.
authors.affiliation: a Département de Biologie, Faculté des Sciences de Tunis, Université Tunis El-Manar, 2092 Tunis, Tunisia.|d Institut National de Recherches en Génie Rural, Eaux et Forêts, Université de Carthage, BP 10, Ariana 2080, Tunisia.
authors.forename: Nizar
authors.initials: N
authors.lastname: Tlili
authors.affiliation: b Unité de Biochimie Macromoléculaire et Génétique, Faculté des Sciences de Gafsa, cité Zarroug, Université de Gafsa, 2112 Tunisia.|c Laboratoire d'Ecophysiologie Animale, Faculté des Sciences de Sfax, 3018, Tunisia.
authors.forename: Anouar
authors.initials: A
authors.lastname: Feriani
authors.affiliation: c Laboratoire d'Ecophysiologie Animale, Faculté des Sciences de Sfax, 3018, Tunisia.
authors.forename: Mohamed Salah
authors.initials: MS
authors.lastname: Allagui
authors.affiliation: d Institut National de Recherches en Génie Rural, Eaux et Forêts, Université de Carthage, BP 10, Ariana 2080, Tunisia.
authors.forename: Ezzeddine
authors.initials: E
authors.lastname: Saadoui
authors.affiliation: d Institut National de Recherches en Génie Rural, Eaux et Forêts, Université de Carthage, BP 10, Ariana 2080, Tunisia.
authors.forename: Abdelhamid
authors.initials: A
authors.lastname: Khaldi
authors.affiliation: a Département de Biologie, Faculté des Sciences de Tunis, Université Tunis El-Manar, 2092 Tunis, Tunisia.
authors.forename: Nizar
authors.initials: N
authors.lastname: Nasri
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000473:pathology; D002945:Cisplatin / Q000633:toxicity*; D005638:Fruit; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D029045:Rhus; D016896:Treatment Outcome
chemical_list: D010936:Plant Extracts; D002251:Carbon Tetrachloride; D002945:Cisplatin
keywords: Rhus tripartitum; hepatoprotective; hépatoprotecteur; nephroprotective; néphroprotecteur