title: Association of HIV and highly active antiretroviral therapy with clinical and biochemical indices among women with pre-eclampsia.
abstract: OBJECTIVE
  To determine whether clinical and biochemical features associated with pre-eclampsia are significantly altered among women with HIV infection taking highly active antiretroviral therapy (HAART).
  
  
  METHODS
  A prospective observational cohort study was conducted between July 2013 and September 2014 at Prince Mshiyeni Memorial Hospital, Durban, South Africa. Women with and without pre-eclampsia and HIV infection were enrolled at booking and followed up until delivery. Specific demographic data, clinical features, laboratory indices, and complications were analyzed.
  
  
  RESULTS
  Of 193 participants, 98 had pre-eclampsia (45 [45.9%] with HIV infection). There were no significant differences in clinical features and laboratory indices among the study groups except for γ-glutamyl transferase levels, which were significantly higher among women with pre-eclampsia and HIV infection (26.9±40.9U/L) than among those with pre-eclampsia but no HIV infection (17.1±14.0U/L; P=0.001). Perinatal and maternal complications were similar, and there were no maternal deaths.
  
  
  CONCLUSIONS
  Clinical features, laboratory indices, and complications among women with pre-eclampsia and HIV infection taking HAART were similar to those among women with pre-eclampsia without HIV infection. Current guidelines remain appropriate; however, frequent hepatic function tests should be conducted.
authors.affiliation: Prince Mshiyeni Memorial Hospital, Durban, South Africa. Electronic address: drray@vodamail.co.za.
authors.forename: Niren R
authors.initials: NR
authors.lastname: Maharaj
authors.affiliation: Women's Health and HIV research group, University of KwaZulu Natal, Durban, South Africa.
authors.forename: Jagidesa
authors.initials: J
authors.lastname: Moodley
authors.affiliation: Department of Medical Biochemistry, University of KwaZulu Natal, Durban, South Africa.
authors.forename: Anil
authors.initials: A
authors.lastname: Chuturgoon
mesh_terms: D000293:Adolescent; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D008875:Middle Aged; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood / Q000188:drug therapy*; D011295:Prenatal Care; D013019:South Africa; D055815:Young Adult; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D005723:gamma-Glutamyltransferase
keywords: Clinical features; HIV; Highly active antiretroviral therapy; Pre-eclampsia