title: Functional polymorphism of lncRNA MALAT1 contributes to pulmonary arterial hypertension susceptibility in Chinese people.
abstract: BACKGROUND
  The long noncoding RNAs (lncRNAs) have gradually been reported to be an important class of RNAs with pivotal roles in regulation of gene expression, and thus are involved in multitudinous human complex diseases. However, the biological functions and precise mechanisms of the majority of lncRNAs are still poorly understood.
  
  
  METHODS
  In the study, we tested genomic variations in lncRNA-metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) loci, and their potentially functional correlationship with pulmonary arterial hypertension (PAH) susceptibility based on a case-control study with a total of 587 PAH patients and 736 healthy controls in southern Chinese.
  
  
  RESULTS
  We found that the rs619586A>G single nucleotide polymorphism (SNP) was significantly associated with PAH risk. The carriers with G variant genotypes had a decreased risk of PAH (odds ratio [OR]=0.69, 95% confidence interval [CI]=0.53-0.90, p=0.007) compared to the rs619586AA genotype. Further functional experiments indicated that the alteration from rs619586A to G in MALAT1 could directly upregulate X box-binding protein 1 (XBP1) expression via functioning as the competing endogenous RNA (ceRNA) for miR-214, and consequentially inhibiting the vascular endothelial cells proliferation and migration in vitro by shortening S-M phase transition.
  
  
  CONCLUSIONS
  Taken together, our findings propose that functional polymorphism rs619586A>G in MALAT1 gene plays an important role in PAH pathogenesis and may serve as a potential indicator for PAH susceptibility.
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Zhuo
authors.forename: Qingchun
authors.initials: Q
authors.lastname: Zeng
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.forename: Guoyang
authors.initials: G
authors.lastname: Li
authors.forename: Qiang
authors.initials: Q
authors.lastname: Xie
authors.forename: Ying
authors.initials: Y
authors.lastname: Cheng
mesh_terms: D044466:Asian People / Q000235:genetics*; D049109:Cell Proliferation; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006976:Hypertension, Pulmonary / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000378:metabolism
chemical_list: C557041:MALAT1 long non-coding RNA, human; D062085:RNA, Long Noncoding