title: Chemo- and Regioselective Direct Functional Group Installation through Catalytic Hydroxy Group Selective Conjugate Addition of Amino Alcohols to α,β-Unsaturated Sulfonyl Compounds.
abstract: A chemoselective functional group installation through catalytic hydroxy group selective conjugate addition of amino alcohols to a variety of functionalized α,β-unsaturated sulfonyl derivatives was developed. Azide group installation for click chemistry and facile fluorescent labeling onto the less reactive hydroxy group demonstrated the synthetic utility of the present chemoselective catalysis. Moreover, chemo- and regioselective reaction of an unprotected amino diol was achieved for the first time.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyushu University , Fukuoka 812-8582, Japan.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Li
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyushu University , Fukuoka 812-8582, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Yazaki
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyushu University , Fukuoka 812-8582, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Ohshima