title: Biological activities of suilysin: role in Streptococcus suis pathogenesis.
abstract: Streptococcus suis is an important swine and zoonotic pathogen equipped with several virulence factors. The pore-forming toxins are the most abundant bacterial toxins and classified as critical virulence (associated) factors of several pathogens. The role of suilysin (SLY), a pore-forming cholesterol-dependent cytolysin of S. suis, as a true virulence factor is under debate. Most of the bacterial toxins have been reported to modulate the host immune system to facilitate invasion and subsequent replication of bacteria within respective host cells. SLY has been demonstrated to play an important role in the pathogenesis of S. suis infection and inflammatory response in vitro and in vivo. This review highlights the contributions of SLY to the pathogenicity of S. suis. It will address its role during the development of S. suis meningitis in pigs, as well as humans, and discuss SLY as a potential vaccine candidate.
authors.affiliation: Pediatric Infectious Diseases, Department of Pediatrics, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, Mannheim D-68167, Germany.
authors.forename: Tobias
authors.initials: T
authors.lastname: Tenenbaum
authors.affiliation: Center for Advanced Studies in Vaccinology and Biotechnology, Brewery Road, University of Balochistan, 87300 Quetta, Pakistan
authors.forename: Tauseef M
authors.initials: TM
authors.lastname: Asmat
authors.affiliation: Institute for Microbiology, University of Veterinary Medicine Hannover, Bischofsholer Damm 15, Hannover D-30173, Germany.
authors.forename: Maren
authors.initials: M
authors.lastname: Seitz
authors.affiliation: Pediatric Infectious Diseases, Department of Pediatrics, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, Mannheim D-68167, Germany.
authors.forename: Horst
authors.initials: H
authors.lastname: Schroten
authors.affiliation: Pediatric Infectious Diseases, Department of Pediatrics, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, Mannheim D-68167, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Schwerk
mesh_terms: D000818:Animals; D002460:Cell Line; D006460:Hemolysin Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D016920:Meningitis, Bacterial / Q000382:microbiology* / Q000503:physiopathology / Q000662:veterinary; D012703:Serotyping; D013290:Streptococcal Infections / Q000276:immunology / Q000382:microbiology* / Q000662:veterinary; D017011:Streptococcus suis / Q000378:metabolism* / Q000472:pathogenicity*; D013552:Swine; D013553:Swine Diseases / Q000382:microbiology*; D037521:Virulence Factors / Q000235:genetics / Q000378:metabolism*; D015047:Zoonoses / Q000382:microbiology
chemical_list: D006460:Hemolysin Proteins; D037521:Virulence Factors; C104760:suilysin
keywords: SLY; Streptococcus suis; pathogenesis; toxin; virulence factors