title: [Applied research of CT angiography of lower extremities by using 100 kVp and iodixanol(270 mg I/ml) combined with iDose(4) iterative reconstruction technique].
abstract: OBJECTIVE
  To evaluate the feasibility of CT angiography of lower extremities by using 100 kVp as tube voltage and Iodixanol(270 mg I/ml) as contrast medium combined with iDose(4) iterative reconstruction technique.
  
  
  METHODS
  A total of 52 continuous patients with clinically suspected lesions of lower extremity arteries underwent CT angiography of lower extremities, divided into 2 groups, and different scan protocols were adopted. "double low" group included 26 patients using 100 kVp, Iodixanol (270 mg I/ml) and iDose(4) -4 iterative reconstruction algorithm; routine group included 26 patients using 120 kVp, Iopromide(370 mg I/ml) and filtered back projection reconstruction algorithm. The total amount of contrast medium in both groups was 95 ml. Artery CT value and background noise at the level of L4 vertebral, hip, knee and ankle were measured, signal to noise ratio (SNR) and contrast to noise ratio (CNR) were calculated, and the quality of images was evaluated subjectively. Scan length (L), volume CT dose index (CTDI(VOL)) and dose length product(DLP) were recorded, and the effective dose (ED) was calculated. The measurement results and subjective evaluation were analyzed statistically. CTA results were analyzed with the digital subtraction angiography (DSA) as the "gold standard".
  
  
  RESULTS
  (1) No significant difference was existed in gender, age, height, weight and body mass index (BMI) of these two groups (P > 0.05). (2) No significant difference was existed in artery CT value, SNR and CNR at the level of L4 vertebral, hip, knee and ankle of the two groups (P > 0.05). Compared with routine group, background noise of "double low" group at the level of hip and knee increased by 16.6% and 13.8%, respectively (P < 0.05). (3) The image quality of the two groups met the requirement of diagnosis, no significant statistical difference was existed in subjective evaluation (P > 0.05). (4) The CTDI(VOL), DLP, ED of "double low" group were lower than that of routine group, with significant statistical difference (P < 0.05). The total amount of iodine in "double group" was lower than that of routine group (25.6 g vs 35.2 g). (5) A total of 7 cases from "double low" group underwent DSA examination, and 18 pathological changes (stenosis and occlusion) were found totally, in which 16 matched CTA; 6 cases from routine group underwent DSA examination, and 15 pathological changes (stenosis and occlusion) were found totally, in which 13 matched. CTA. No significant statistical difference was existed between the two groups in diagnostic efficacy (P = 0.626).
  
  
  CONCLUSIONS
  Using 100 kVp and Iodixanol (270 mg I/ml) combined with iDose(4) -4 iterative reconstruction technique for CT angiography of lower extremities, the image quality could meet the requirement for clinical diagnosis, the radiation dose and the volume of contrast medium could be lowered.
authors.forename: Bo
authors.initials: B
authors.lastname: Chen
authors.forename: Lei
authors.initials: L
authors.lastname: Xu
authors.forename: Jianmin
authors.initials: J
authors.lastname: Cheng
authors.forename: Hui
authors.initials: H
authors.lastname: He
authors.forename: Qiuyan
authors.initials: Q
authors.lastname: Kong
authors.forename: Zhihan
authors.initials: Z
authors.lastname: Yan
authors.forename: Xin
authors.initials: X
authors.lastname: Xu
authors.forename: Shan
authors.initials: S
authors.lastname: Xiong
mesh_terms: D000465:Algorithms; D015901:Angiography, Digital Subtraction; D015992:Body Mass Index; D001835:Body Weight; D003287:Contrast Media / Q000737:chemistry*; D005240:Feasibility Studies; D006801:Humans; D007472:Iohexol / Q000031:analogs & derivatives / Q000737:chemistry; D035002:Lower Extremity; D011829:Radiation Dosage; D011857:Radiographic Image Interpretation, Computer-Assisted; D059629:Signal-To-Noise Ratio; D014057:Tomography, X-Ray Computed; D014283:Triiodobenzoic Acids / Q000737:chemistry*
chemical_list: D003287:Contrast Media; D014283:Triiodobenzoic Acids; D007472:Iohexol; C038192:iopromide; C044834:iodixanol