title: Low-Level Environmental Lead Exposure and Dysglycemia in Adult Individuals: Results from the Canadian Health and Measure Survey 2007-2011.
abstract: We aimed to evaluate the association of exposure to lead with glycated hemoglobin (HbA1c), fasting glucose levels (FGLs), and the likelihood for dysglycemia. We accessed data from Canada Health and Measures Survey. General linear models were used to estimate the association between blood lead concentrations (BPb) and both HbA1c and FGLs, while controlling for confounders. Multivariate logistic regression was used for assessing the relation between BPb and the likelihood for dysglycemia. FGLs in participants with moderate BPb (2.5-5.0 μg/dL) were 1.03 (95 % CI 1.00-1.06) times higher compared with participants with BPb < 2.5 μg/dL. Equivalent figures for those with BPb ≥ 5.0 μg/dL were 1.10 (95 % CI 1.01-1.20) times, relative to the lowest stratum. This association was attenuated using HbA1c to define dysglycemia. Lead exposure was associated with the likelihood for neither FGLs ≥ 1.10 g/L nor HbA1c ≥ 5.7 %. The association between lead exposure and dysglycemia, if any, is likely to be very modest, at least at the population level.
authors.affiliation: Population Health and Optimal Health Practices Research Unit, CHUQ Research Center, Faculty of Medicine, Laval University, Bureau JS1-13, 1050 Chemin Sainte-Foy, Québec, QC, G1S 4L8, Canada. ngueta@hotmail.com.|Department of Occupational and Environmental Health, School of Public Health, Université de Montréal, Montreal, Canada. ngueta@hotmail.com.
authors.forename: Gerard
authors.identifier: http://orcid.org/0000-0002-6794-9873
authors.initials: G
authors.lastname: Ngueta
authors.affiliation: Non-Communicable Diseases Research Unit, South African Medical Research Council and University of Cape Town, Cape Town, South Africa.
authors.forename: André Pascal
authors.initials: AP
authors.lastname: Kengne
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002170:Canada / Q000453:epidemiology; D002648:Child; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D044882:Glucose Metabolism Disorders / Q000097:blood / Q000139:chemically induced / Q000453:epidemiology; D006801:Humans; D007854:Lead / Q000493:pharmacokinetics / Q000633:toxicity; D008297:Male; D008875:Middle Aged
chemical_list: D007854:Lead
keywords: Adults; Fasting glucose levels; Glycated hemoglobin; Lead exposure