title: Physiological role for amyloid precursor protein in adult experience-dependent plasticity.
abstract: Changes in neural circuits after experience-dependent plasticity are brought about by the formation of new circuits via axonal growth and pruning. Here, using a combination of electrophysiology, adeno-associated virus-delivered fluorescent proteins, analysis of mutant mice, and two-photon microscopy, we follow long-range horizontally projecting axons in primary somatosensory cortex before and after selective whisker plucking. Whisker plucking induces axonal growth and pruning of horizontal projecting axons from neurons located in the surrounding intact whisker representations. We report that amyloid precursor protein is crucial for axonal pruning and contributes in a cell autonomous way.
authors.affiliation: Laboratory of Neurobiology, The Rockefeller University, New York, NY 10065;
authors.forename: Sally A
authors.initials: SA
authors.lastname: Marik
authors.affiliation: Laboratory of Brain Development and Repair, The Rockefeller University, New York, NY 10065.
authors.forename: Olav
authors.initials: O
authors.lastname: Olsen
authors.affiliation: Laboratory of Neurobiology, The Rockefeller University, New York, NY 10065;
authors.forename: Marc
authors.initials: M
authors.lastname: Tessier-Lavigne
authors.affiliation: Laboratory of Neurobiology, The Rockefeller University, New York, NY 10065; gilbert@rockefeller.edu.
authors.forename: Charles D
authors.initials: CD
authors.lastname: Gilbert
mesh_terms: D016564:Amyloid beta-Protein Precursor / Q000502:physiology*; D000818:Animals; D051379:Mice; D009473:Neuronal Plasticity
chemical_list: D016564:Amyloid beta-Protein Precursor
keywords: amyloid precursor protein; axon pruning; experience-dependent plasticity; long-range axons; somatosensory cortex