title: [P200 parameters in patients with diabetes mellitus type 2 (DM2)].
abstract: BACKGROUND
  A complication underserved in diabetic patients is the cognitive deficits that can reach dementia. Studying the association between electrophysiological, neuropsychological, and biochemical measures could provide a breakthrough in the understanding of this phenomenon.
  
  
  OBJECTIVE
  To compare P200 parameters between subjects with and without diabetes mellitus type 2 and to determine their relationship with biochemical and neuropsychological indicators.
  
  
  METHODS
  This is an observational, prospective, transversal and analytical study. Seventy-four participants were divided into two groups: 37 with diabetes mellitus type 2, and 37 subjects as controls. P200 latency, amplitude, and rate of rise to somatosensory stimuli were measured and related to the Mini Mental State Examination (MMSE) test and blood glucose and glycosylated hemoglobin.
  
  
  RESULTS
  Diabetics showed longer latency (p < 0.042, 1-tail) and lower MMSE score (p < 0.0001) than controls. Negative associations of amplitude and rising rate with glycosylated hemoglobin were observed in patients (p < 0.025); also, between amplitude and blood glucose (p < 0.038, 1-tail) and between MMSE score and time with diabetes mellitus type 2 (p < 0.007).
  
  
  CONCLUSIONS
  The P200 parameters of the somatosensory system are sensitive to metabolic deterioration of diabetic patients, so its use in monitoring the cognitive state of patients is recommended.
authors.affiliation: Hospital General de Especialidades Dr. Javier Buenfil Osorio, Secretaría de Salud, Campeche, Camp., México.|Centro de Investigaciones Biomédicas, Universidad Autónoma de Campeche, Campeche, Camp., México.
authors.forename: Oscar H
authors.initials: OH
authors.lastname: Hernández
authors.affiliation: Hospital General de Especialidades Dr. Javier Buenfil Osorio, Secretaría de Salud, Campeche, Camp., México.
authors.forename: Luisa
authors.initials: L
authors.lastname: Aguirre-Manzo
authors.affiliation: Hospital General de Especialidades Dr. Javier Buenfil Osorio, Secretaría de Salud, Campeche, Camp., México.
authors.forename: Freddy
authors.initials: F
authors.lastname: Ye-Ehuan
authors.affiliation: Centro de Investigaciones Biomédicas, Universidad Autónoma de Campeche, Campeche, Camp., México.
authors.forename: Rolando
authors.initials: R
authors.lastname: García-Martínez
authors.affiliation: Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Campeche, Campeche, Camp., México.
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Maldonado-Velázquez
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000502:physiology*; D003072:Cognition Disorders / Q000453:epidemiology / Q000209:etiology*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011446:Prospective Studies
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin