title: Potential clinical impact of the film array meningitis encephalitis panel in children with suspected central nervous system infections.
abstract: The FilmArray Meningitis Encephalitis Panel, a multiplex PCR for testing of cerebrospinal fluid, was compared to conventional diagnostic methods in children with suspected central nervous system infections. The panel had comparable diagnostic yield (96% agreement) and improved time-to-diagnosis by 10.3 hours with potential for more judicious antimicrobial use, particularly acyclovir.
authors.affiliation: University of Colorado/Children's Hospital Colorado Department of Pediatrics, Section of Infectious Diseases, Aurora, CO, USA; University of Colorado/Children's Hospital Colorado Department of Pediatrics, Section of Hospital Medicine, Aurora, CO, USA. Electronic address: kevin.messacar@childrenscolorado.org.
authors.forename: Kevin
authors.initials: K
authors.lastname: Messacar
authors.affiliation: Children's Hospital Colorado, Department of Pathology and Laboratory Medicine, Aurora, CO, USA.
authors.forename: Garrett
authors.initials: G
authors.lastname: Breazeale
authors.affiliation: Children's Hospital Colorado, Department of Pathology and Laboratory Medicine, Aurora, CO, USA.
authors.forename: Christine C
authors.initials: CC
authors.lastname: Robinson
authors.affiliation: University of Colorado/Children's Hospital Colorado Department of Pediatrics, Section of Infectious Diseases, Aurora, CO, USA; Children's Hospital Colorado Department of Epidemiology, Aurora, CO, USA.
authors.forename: Samuel R
authors.initials: SR
authors.lastname: Dominguez
mesh_terms: D001419:Bacteria / Q000145:classification / Q000302:isolation & purification; D002555:Cerebrospinal Fluid / Q000382:microbiology* / Q000821:virology*; D002648:Child; D002675:Child, Preschool; D004660:Encephalitis / Q000175:diagnosis*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008581:Meningitis / Q000175:diagnosis*; D025202:Molecular Diagnostic Techniques / Q000379:methods*; D060885:Multiplex Polymerase Chain Reaction / Q000379:methods*; D012189:Retrospective Studies; D013997:Time Factors; D014780:Viruses / Q000145:classification / Q000302:isolation & purification
keywords: Acyclovir; Central nervous system infection; Cerebrospinal fluid; Encephalitis; Meningitis; Rapid diagnostics