title: An overall and dose-response meta-analysis for thyrotropin and thyroid cancer risk by histological type.
abstract: Thyrotropin (TSH) is thought as a risk factor for thyroid cancer. However, the effect of serum TSH might depend on histological types of thyroid cancer. We searched for related studies including serum TSH as an exposure and thyroid cancer as a result in PUBMED, EMBASE and Chinese National Knowledge Infrastructure up to April 21, 2016. This meta-analysis included 22 articles with 53,538 participants. When comparing all histological thyroid cancer, the pooled odds ratios of thyroid cancer in patients with nodules was found to increase significantly with higher serum TSH concentrations for differentiated thyroid carcinoma (1.88 vs .1.48, P = 0.0000) and papillary thyroid carcinoma (2.08 vs. 1.48, P = 0.0006). Each 1 mU/L increase of serum TSH was associated with 14% greater risk of thyroid cancer for all histological thyroid cancer, 16% for differentiated thyroid carcinoma and 22% for papillary thyroid carcinoma. In addition, high serum TSH was associated with a reduced risk for follicular thyroid carcinoma (OR = 0.73, 95% CI: 0.52, 1.02). This meta-analysis suggested high serum TSH concentration is risky for papillary thyroid carcinoma but not for follicular thyroid carcinoma.
authors.affiliation: Institute of Biomedical Sciences, Minhang Hospital, Fudan University, Shanghai, P.R. China.|School of Public Health Taishan Medical University, Shandong, P.R. China.
authors.forename: Na
authors.initials: N
authors.lastname: Hu
authors.affiliation: Ruijin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, P.R. China.
authors.forename: Zhan-Ming
authors.initials: ZM
authors.lastname: Li
authors.affiliation: Institute of Biomedical Sciences, Minhang Hospital, Fudan University, Shanghai, P.R. China.|School of Public Health Taishan Medical University, Shandong, P.R. China.
authors.forename: Jin-Feng
authors.initials: JF
authors.lastname: Liu
authors.affiliation: Institute of Biomedical Sciences, Minhang Hospital, Fudan University, Shanghai, P.R. China.|School of Public Health Taishan Medical University, Shandong, P.R. China.
authors.forename: Zhen-Zhen
authors.initials: ZZ
authors.lastname: Zhang
authors.affiliation: Institute of Biomedical Sciences, Minhang Hospital, Fudan University, Shanghai, P.R. China.
authors.forename: Li-Shun
authors.initials: LS
authors.lastname: Wang
mesh_terms: D006801:Humans; D012307:Risk Factors; D013964:Thyroid Neoplasms / Q000097:blood* / Q000473:pathology*; D013972:Thyrotropin / Q000097:blood*
chemical_list: D013972:Thyrotropin
keywords: differentiated thyroid carcinoma; meta-analysis; papillary thyroid carcinoma; serum thyrotropin; thyroid cancer