title: The relation of protein C and protein S levels with cardiovascular risk in patients with diabetic neuropathy.
abstract: BACKGROUND
  This study was conducted to determine the clinically significance of protein C and protein S levels as a cardiovascular risk marker in patients with diabetic neuropathy.
  
  
  METHODS
  We included 71 subjects. 50 of them were diabetics, 27 of them also had diabetic neuropathy(DN), 21 subjects were non diabetic. We evaluated these 3 group subjects' protein C, protein S, fibrinogen, prothrombine time (PT), activated partial thromboplastine time (aPTT), total cholesterol, levels and Framingham Coronary Risk Score (FCRS).
  
  
  RESULTS
  Non diabetic group's protein C levels were higher than patients with DN (p<0.05) and diabetic patients without DN (p<0.05). But there were no difference in terms of protein C levels between patients with DN and diabetic patients without DN. FCRS of control group was lower than diabetic subjects(p<0.01).
  
  
  CONCLUSIONS
  We found that protein C and S levels were much lower in diabetic patients than non diabetics.There was no difference between diabetic patients with DN and diabetic patients without DN in terms of protein C and protein S levels. Further, we couldn't detect any finding that we can say protein C and Protein S levels can be used as a cardiovascular risk assessment marker in diabetic neuropathic patients.
authors.affiliation: Umraniye Education and Research Hospital, Internal Medicine Clinic, Istanbul, Turkey. Electronic address: drhsaktas@gmail.com.
authors.forename: H Şerife
authors.initials: HŞ
authors.lastname: Aktaş
authors.affiliation: Umraniye Education and Research Hospital, Internal Medicine Clinic, Istanbul, Turkey.
authors.forename: Sema
authors.initials: S
authors.lastname: Ucak
authors.affiliation: Umraniye Education and Research Hospital, Internal Medicine Clinic, Istanbul, Turkey.
authors.forename: M Behçet
authors.initials: MB
authors.lastname: Demirbaş
authors.affiliation: Umraniye Education and Research Hospital, Internal Medicine Clinic, Istanbul, Turkey.
authors.forename: Zehra
authors.initials: Z
authors.lastname: Sarikaya
authors.affiliation: Umraniye Education and Research Hospital, Internal Medicine Clinic, Istanbul, Turkey.
authors.forename: Gülçin Güngör
authors.initials: GG
authors.lastname: Olçum
authors.affiliation: Umraniye Education and Research Hospital,Clinical Biochemistry, Istanbul, Turkey.
authors.forename: Eker
authors.initials: E
authors.lastname: Pınar
mesh_terms: D015415:Biomarkers / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000150:complications* / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011486:Protein C / Q000378:metabolism*; D017293:Protein S / Q000378:metabolism*; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D011486:Protein C; D017293:Protein S
keywords: Diabetic neuropathy; Protein C; Protein S