title: Repeated Hepatectomy for Recurrent Intrahepatic Cholangiolocellular Carcinoma: Report of a Case.
abstract: The patient was a 59-year-old female. A liver tumor measuring 10 cm was found in the right hepatic lobe by medical examination of August, 2008 and she underwent extended right hepatectomy in September. Microscopically, the tumor was composed of small cuboidal cells possessing oval nuclei and resembling cholangiole. These formed small tubular structures with fibrous stroma. From a result of histopathological features, a diagnosis of a cholangiolocellular carcinoma was made. She received postoperative adjuvant chemotherapy with gemcitabine and S-1. After that, the patient underwent six partial hepatectomies by August, 2013 for recurrent intrahepatic cholangiolocellular carcinoma. The patient is doing well 7 years after the first hepatectomy. Cholangiolocellular carcinoma is a rare tumor accounting for less than 1% of primary liver cancer, and the clinicopathologic features are not fully understood. Aggressive surgical resection may be one of the choices to assure a good outcome.
authors.affiliation: Department of Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan. tomiokumifuji@tokai-u.jp.
authors.forename: Mifuji
authors.initials: M
authors.lastname: Tomioku
authors.forename: Naoki
authors.initials: N
authors.lastname: Yazawa
authors.forename: Daisuke
authors.initials: D
authors.lastname: Furukawa
authors.forename: Hideki
authors.initials: H
authors.lastname: Izumi
authors.forename: Taro
authors.initials: T
authors.lastname: Mashiko
authors.forename: Soji
authors.initials: S
authors.lastname: Ozawa
authors.forename: Sotaro
authors.initials: S
authors.lastname: Sadahiro
authors.forename: Seiei
authors.initials: S
authors.lastname: Yasuda
authors.forename: Kenichi
authors.initials: K
authors.lastname: Hirabayashi
authors.forename: Toshio
authors.initials: T
authors.lastname: Nakagohri
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D018281:Cholangiocarcinoma / Q000000981:diagnostic imaging / Q000601:surgery* / Q000648:ultrastructure; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D004338:Drug Combinations; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000601:surgery* / Q000648:ultrastructure; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging / Q000601:surgery*; D010094:Oxonic Acid / Q000008:administration & dosage; D012086:Reoperation; D013534:Survival; D005641:Tegafur / Q000008:administration & dosage; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D000093542:Gemcitabine
chemical_list: D004338:Drug Combinations; D003841:Deoxycytidine; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D000093542:Gemcitabine