title: Protective effect of magnolol-loaded polyketal microparticles on lipopolysaccharide-induced acute lung injury in rats.
abstract: Magnolol has shown inhibitory effects on NO production and TNF-alpha production in lipopolysaccharide (LPS)-activated macrophages and LPS-induced acute lung injury; however, the poor solubility of magnolol has hindered its clinical success. In this study, magnolol-loaded microparticles were prepared via single emulsion method from a polyketal polymer, termed PK3. The particle sizes of magnolol-loaded PK3 microparticle is 3.73 ± 0.41 μm, and was suitable for phagocytosis by macrophages and pulmonary drug delivery. PK3 microparticles exhibited excellent biocompatibility both in vitro and in vivo. More importantly, intratracheal delivery of these magnolol-loaded microparticles significantly reduced the lung inflammatory responses at low dosage of magnolol (0.5 mg/kg), and have great clinical potential in treating acute lung injury.
authors.affiliation: a Graduate Institute of Biomedical Materials and Tissue Engineering, Taipei Medical University , Taipei , Taiwan ;
authors.forename: Tsuimin
authors.initials: T
authors.lastname: Tsai
authors.affiliation: b Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology , Taipei , Taiwan ;|c Department of Biomedical Engineering , National Defense Medical Center , Taipei , Taiwan ;
authors.forename: Chen-Yu
authors.initials: CY
authors.lastname: Kao
authors.affiliation: b Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology , Taipei , Taiwan ;
authors.forename: Chun-Liang
authors.initials: CL
authors.lastname: Chou
authors.affiliation: b Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology , Taipei , Taiwan ;
authors.forename: Lu-Chun
authors.initials: LC
authors.lastname: Liu
authors.affiliation: d Graduate Institute of Medical Sciences, National Defense Medical Center , Taipei , Taiwan ;|e Institute of Medical Sciences, Tzu Chi University , Hualien , Taiwan.
authors.forename: Tz-Chong
authors.initials: TC
authors.lastname: Chou
mesh_terms: D055371:Acute Lung Injury / Q000139:chemically induced / Q000188:drug therapy; D000818:Animals; D001713:Biphenyl Compounds / Q000737:chemistry / Q000494:pharmacology*; D016503:Drug Delivery Systems / Q000379:methods*; D017705:Lignans / Q000737:chemistry / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000633:toxicity*; D008297:Male; D051379:Mice; D000067996:RAW 264.7 Cells; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D001713:Biphenyl Compounds; D017705:Lignans; D008070:Lipopolysaccharides; C005498:magnolol
keywords: Magnolol; acute lung injury; anti-inflammatory. pulmonary drug delivery; polyketal microparticles