title: Correlations of Cerebrospinal Fluid/Plasma Fibroblast Growth Factor 21 Ratio with Metabolic Parameters in Chinese Individuals of Normal Weight.
abstract: BACKGROUND
  Fibroblast growth factor 21 (FGF21) is an important metabolic regulator that has multiple beneficial effects on glucose homeostasis and lipid metabolism. Although circulating levels of FGF21 are mainly derived from liver, FGF21 is also found in other tissues and fluids including the cerebrospinal fluid (CSF). The aim of the present study was to investigate the relationships of CSF and/or plasma FGF21 levels with metabolic parameters in a normal-weight Chinese population.
  
  
  METHODS
  Forty-five subjects (22 males and 23 females) were recruited from a patient population undergoing surgery for lower extremity injuries due to ligament damage or bone fractures below the knee in the Beijing Jishuitan Hospital. The levels of FGF21 in CSF and plasma were determined by radioimmunoassay and enzyme-linked immunosorbent assay, respectively.
  
  
  RESULTS
  No significant differences were detected in the levels of FGF21 in CSF and plasma between males (CSF: 158.01 ± 12.10 pg/mL; plasma: 206.19 ± 7.22 pg/mL) and females (CSF: 159.27 ± 17.85 pg/mL; plasma: 203.10 ± 7.53 pg/mL). The level of FGF21 in CSF was about 75% of that in plasma. The FGF21 level in CSF was positively correlated with triglyceride level, whereas plasma FGF21 level was negatively correlated with alanine aminotransferase in women but not in men. The CSF/plasma FGF21 ratio was positively correlated with CSF FGF21 in both genders and with peripheral glucose, triglyceride, and gamma-glutamyl transferase levels in female Chinese patients.
  
  
  CONCLUSIONS
  These results have important implications regarding the potential central actions of FGF21.
authors.forename: Qiujun
authors.initials: Q
authors.lastname: Li
authors.forename: Yang
authors.initials: Y
authors.lastname: Yu
authors.forename: Yimin
authors.initials: Y
authors.lastname: Kang
authors.forename: Jinzhong
authors.initials: J
authors.lastname: Xu
authors.forename: Hong
authors.initials: H
authors.lastname: Lin
authors.forename: Xiaofang
authors.initials: X
authors.lastname: Wang
authors.forename: Lingxia
authors.initials: L
authors.lastname: Pang
authors.forename: Lufeng
authors.initials: L
authors.lastname: Hu
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Yang
authors.forename: Wei
authors.initials: W
authors.lastname: Zuo
authors.forename: Guoshi
authors.initials: G
authors.lastname: Qiu
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Jiang
authors.forename: Cunbao
authors.initials: C
authors.lastname: Li
authors.forename: Geng
authors.initials: G
authors.lastname: Wang
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D015992:Body Mass Index; D001835:Body Weight; D005260:Female; D005346:Fibroblast Growth Factors / Q000097:blood* / Q000134:cerebrospinal fluid*; D006801:Humans; D008297:Male; D014280:Triglycerides / Q000097:blood; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D014280:Triglycerides; C414620:fibroblast growth factor 21; D005346:Fibroblast Growth Factors; D005723:gamma-Glutamyltransferase; D000410:Alanine Transaminase