title: Organocatalytic Doubly Annulative Approach to 3,4-Dihydrocoumarins Bearing a Fused Pyrrolidine Scaffold.
abstract: A new strategy for the highly enantio- and diastereoselective synthesis of 3,4-dihydrocoumarin derivatives bearing a fused pyrrolidine ring is reported. It is based on a Brønsted base catalyzed cascade reactivity between β,γ-unsaturated-α-ketophosphonates and imines (derived from various salicylaldehydes and diethyl aminomalonate). The approach can be described as a doubly annulative strategy where both the pyrrolidine moiety and the δ-lactone ring of the 3,4-dihydrocoumarin framework are constructed starting from acyclic precursors.
authors.affiliation: Institute of Organic Chemistry, Chemistry Department, Lodz University of Technology , Żeromskiego 116, 90-924 Łódź, Poland.
authors.forename: Dorota
authors.initials: D
authors.lastname: Kowalczyk
authors.affiliation: Institute of Organic Chemistry, Chemistry Department, Lodz University of Technology , Żeromskiego 116, 90-924 Łódź, Poland.
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Albrecht