title: Treatment Outcome Following Transarterial Chemoembolization in Advanced Bone and Soft Tissue Sarcomas.
abstract: OBJECTIVE
  Transarterial chemoembolization (TACE) is used to treat unresectable bone and soft tissue sarcoma (STS) and as a pre-surgical adjuvant treatment. However, its efficiency for advanced STS is undetermined. This study evaluated TACE's efficiency in treating advanced STS and prognostic factors for patient survival.
  
  
  METHODS
  We enrolled 39 patients with unresectable STS who underwent TACE as an alternative treatment during 2010-2014, with overall survival (OS) as the primary end point. Cancer pain was evaluated by visual analogue scores (VAS) before and after TACE procedures. Factors that affect survival were evaluated by multivariate analyses (Cox proportional hazard model).
  
  
  RESULTS
  Mean OS after TACE was 23.7 ± 2.1 months, with 1-year OS 71.5 %, 2-year OS 45.8 %, and 3-year OS 32.5 %. Lesion number and tumor stage were key predictors of survival. TACE was found to decrease cancer pain VAS and increase relapse interval. Size of polyvinyl alcohol (PVA) particle diameter (P = 0.03) and imaging response (P = 0.044) were also found to affect relapse interval.
  
  
  CONCLUSIONS
  TACE was an effective treatment for advanced STS, with a 32.5 % 3-year OS rate, and led to lower cancer pain VAS and longer relapse intervals than chemoinfusion only. Smaller PVA particles are preferable during the TACE procedure.
authors.affiliation: Department of Radiology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, 600 Yi-Shan Road, Shanghai, 200233, People's Republic of China.
authors.forename: Chunyu
authors.initials: C
authors.lastname: Jiang
authors.affiliation: Department of Radiology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, 600 Yi-Shan Road, Shanghai, 200233, People's Republic of China. a602131499@163.com.
authors.forename: Jianbo
authors.identifier: http://orcid.org/0000-0003-3027-6967
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Oncology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, 200233, People's Republic of China.
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Radiology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, 600 Yi-Shan Road, Shanghai, 200233, People's Republic of China.
authors.forename: Jungong
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Radiology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, 600 Yi-Shan Road, Shanghai, 200233, People's Republic of China.
authors.forename: Yueqi
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Radiology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, 600 Yi-Shan Road, Shanghai, 200233, People's Republic of China.
authors.forename: Xu
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Radiology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, 600 Yi-Shan Road, Shanghai, 200233, People's Republic of China.
authors.forename: Jia
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of General Surgery, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, 200233, People's Republic of China.
authors.forename: Xuebing
authors.initials: X
authors.lastname: Yan
mesh_terms: D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000628:therapy*; D016461:Chemoembolization, Therapeutic; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012509:Sarcoma / Q000628:therapy*; D012983:Soft Tissue Neoplasms / Q000628:therapy*; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult
keywords: Bone sarcoma; Overall survival; Prognosis; Soft tissue sarcoma; Transarterial chemoembolization