title: The Impact of Remote Ischemic Preconditioning on Arterial Stiffness and Heart Rate Variability in Patients with Angina Pectoris.
abstract: Remote ischemic preconditioning (RIPC) is the set of ischemia episodes that protects against subsequent periods of prolonged ischemia through the cascade of adaptive responses; however, the mechanisms of RIPC are not entirely clear. Here, we aimed to study the impact of RIPC in patients with stable angina pectoris and compare it with healthy individuals with respect to arterial stiffness and heart rate variability. In the randomized, sham-controlled, crossover blind design study, a group of 30 coronary heart disease (CHD) patients (63.9 ± 1.6 years) with stable angina pectoris NYHA II-III and a control group of 20 healthy individuals (58.2 ± 2.49) were both randomly allocated for remote RIPC or sham RIPC. Arterial stiffness, pulse wave velocity (Spygmacor, Australia), and heart rate variability (HRV) were recorded before and after the procedure followed by the crossover examination. In the group of healthy individuals, RIPC showed virtually no impact on the cardiovascular parameters, while, in the CHD group, the systolic and central systolic blood pressure, central pulse pressure, and augmentation decreased, and total power of HRV improved. We conclude that ischemic preconditioning reduces not only systolic blood pressure, but also reduces central systolic blood pressure and improves arterial compliance and heart rate modulation reserve, which may be associated with the antianginal effect of preconditioning.
authors.affiliation: Department of Internal Diseases, Bashkir State Medical University, Ufa, 450000, Russia. znaufal@mail.ru.
authors.forename: Naufal
authors.initials: N
authors.lastname: Zagidullin
authors.affiliation: Department of Internal Diseases, Bashkir State Medical University, Ufa, 450000, Russia. alnushka555@mail.ru.
authors.forename: Elena
authors.initials: E
authors.lastname: Scherbakova
authors.affiliation: Department of Internal Diseases, Bashkir State Medical University, Ufa, 450000, Russia. y.f.safina@mail.ru.
authors.forename: Yuliana
authors.initials: Y
authors.lastname: Safina
authors.affiliation: Department of Internal Diseases, Bashkir State Medical University, Ufa, 450000, Russia. zrustem@ufanet.ru.
authors.forename: Rustem
authors.initials: R
authors.lastname: Zulkarneev
authors.affiliation: Department of Internal Diseases, Bashkir State Medical University, Ufa, 450000, Russia. zshamil@inbox.ru.
authors.forename: Shamil
authors.initials: S
authors.lastname: Zagidullin
keywords: RIPC; angina pectoris; arterial stiffness; heart rate variability