title: Anti-TIF1-γ antibody and cancer-associated myositis: A clinicohistopathologic study.
abstract: We aimed to analyze the clinical and histopathologic features of cancer-associated myositis (CAM) in relation to anti-transcriptional intermediary factor 1 γ antibody (anti-TIF1-γ-Ab), a marker of cancer association.
  
  
  
  We retrospectively studied 349 patients with idiopathic inflammatory myopathies (IIMs), including 284 patients with pretreatment biopsy samples available. For the classification of IIMs, the European Neuromuscular Center criteria were applied. Patients with CAM with (anti-TIF1-γ-Ab[+] CAM) and without anti-TIF1-γ-Ab (anti-TIF1-γ-Ab[-] CAM) were compared with patients with IIM without cancers within and beyond 3 years of myositis diagnosis.
  
  
  
  Cancer was detected in 75 patients, of whom 36 (48%) were positive for anti-TIF1-γ-Ab. In anti-TIF1-γ-Ab(+) patients with CAM, cancers were detected within 1 year of myositis diagnosis in 35 (97%) and before 1 year of myositis diagnosis in 1. All the anti-TIF1-γ-Ab(+) patients with CAM satisfied the dermatomyositis (DM) criteria, including 2 possible DM sine dermatitis cases, and were characterized histologically by the presence of perifascicular atrophy, vacuolated fibers (VFs), and dense C5b-9 deposits on capillaries (dC5b-9). In contrast, 39 anti-TIF1-γ-Ab(-) patients with CAM were classified into various subgroups, and characterized by a higher frequency of necrotizing autoimmune myopathy (NAM). Notably, all 7 patients with CAM classified into the NAM subgroup were anti-TIF1-γ-Ab(-) and exhibited no dC5b-9 or VFs.
  
  
  
  CAM includes clinicohistopathologically heterogeneous disease entities. Among CAM entities, anti-TIF1-γ-Ab(+) CAM has characteristically shown a close temporal association with cancer detection and the histopathologic findings of dC5b-9 and VFs, and CAM with NAM is a subset of anti-TIF1-γ-Ab(-) CAM.
authors.forename: Ayumi
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authors.lastname: Hida
authors.forename: Takenari
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authors.lastname: Yamashita
authors.forename: Yuji
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authors.lastname: Hosono
authors.forename: Manami
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authors.lastname: Inoue
authors.forename: Kenichi
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authors.lastname: Kaida
authors.forename: Masato
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authors.lastname: Kadoya
authors.forename: Yusuke
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authors.lastname: Miwa
authors.forename: Nobuyuki
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authors.lastname: Yajima
authors.forename: Reika
authors.initials: R
authors.lastname: Maezawa
authors.forename: Satoko
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authors.lastname: Arai
authors.forename: Kazuhiro
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authors.lastname: Kurasawa
authors.forename: Kazuhiro
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authors.forename: Hiroyuki
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authors.lastname: Shimada
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authors.forename: Masahiro
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authors.forename: Shigeo
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authors.forename: Ayumi
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authors.lastname: Uchibori
authors.forename: Atsuro
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authors.forename: Hitoshi
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authors.lastname: Aizawa
authors.forename: Takayuki
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authors.lastname: Momoo
authors.forename: Yoshiharu
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authors.lastname: Nakae
authors.forename: Yasuhisa
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authors.lastname: Sakurai
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Shiio
authors.forename: Hideji
authors.initials: H
authors.lastname: Hashida
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Yoshizawa
authors.forename: Yoshio
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authors.lastname: Sakiyama
authors.forename: Aya
authors.initials: A
authors.lastname: Oda
authors.forename: Kiyoharu
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authors.lastname: Inoue
authors.forename: Sousuke
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authors.lastname: Takeuchi
authors.forename: Nobue K
authors.initials: NK
authors.lastname: Iwata
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Date
authors.forename: Naoki
authors.initials: N
authors.lastname: Masuda
authors.forename: Takashi
authors.initials: T
authors.lastname: Mikata
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Motoyoshi
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Uesaka
authors.forename: Meiko Hashimoto
authors.initials: MH
authors.lastname: Maeda
authors.forename: Ran
authors.initials: R
authors.lastname: Nakashima
authors.forename: Shoji
authors.initials: S
authors.lastname: Tsuji
authors.forename: Shin
authors.initials: S
authors.lastname: Kwak
authors.forename: Tsuneyo
authors.initials: T
authors.lastname: Mimori
authors.forename: Jun
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authors.lastname: Shimizu
mesh_terms: D051017:Apoptosis Regulatory Proteins / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D009220:Myositis / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000276:immunology*; D009369:Neoplasms / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000276:immunology*; D009687:Nuclear Proteins / Q000276:immunology*; D012189:Retrospective Studies; D009218:Myosins
chemical_list: D051017:Apoptosis Regulatory Proteins; D001323:Autoantibodies; D015415:Biomarkers; D009687:Nuclear Proteins; C407152:MYO18A protein, human; D009218:Myosins