title: One-Pot Cascade Reactions Leading to Pyrido[2',1':2,3]imidazo[4,5-c][1,2,3]triazolo[1,5-a]quinolines under Bimetallic Relay Catalysis with Air as the Oxidant.
abstract: In this paper, we report an efficient one-pot synthesis of 1,2,3-triazole/quinoline-fused imidazo[1,2-a]pyridines starting from 2-(2-bromophenyl)imidazo[1,2-a]pyridines, alkynes, and sodium azide. This novel method involves a one-pot bimetallic relay-catalyzed cascade process combining azide-alkyne cycloaddition, C-N coupling between 1,2,3-triazole and aryl bromide, and intramolecular cross dehydrogenative C-C coupling between 1,2,3-triazole and imidazo[1,2-a]pyridine. Notable features of this protocol include simple starting materials, sustainable oxidants, reduced synthetic steps, and high efficiency.
authors.affiliation: School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University , Xinxiang, Henan 453007, China.
authors.forename: Ze
authors.initials: Z
authors.lastname: Wang
authors.affiliation: School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University , Xinxiang, Henan 453007, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.affiliation: School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University , Xinxiang, Henan 453007, China.
authors.forename: Xinying
authors.initials: X
authors.lastname: Zhang
authors.affiliation: School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University , Xinxiang, Henan 453007, China.
authors.forename: Xuesen
authors.initials: X
authors.lastname: Fan