title: Denosumab: a case of MRONJ with resolution.
abstract: A patient was referred by a clinical oncologist regarding a non-healing area of bone in the lower jaw. The patient was taking denosumab (Prolia(®), Xgeva(®)) when they had a tooth extracted and the area failed to heal. Following suspension of the drug, the area healed with mucosal coverage. This new class of drugs are being increasingly used as an alternative antiresorptive drug to bisphosphonates and are licenced in the UK for prevention of osteoporotic fractures and prevention of skeletal-related events (SREs) in patients with metastatic cancer.
authors.affiliation: CT1.
authors.forename: C V
authors.initials: CV
authors.lastname: Lyttle
authors.affiliation: Glasgow Dental Hospital.
authors.forename: H
authors.initials: H
authors.lastname: Patterson
mesh_terms: D000368:Aged; D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw; D050071:Bone Density Conservation Agents / Q000009:adverse effects*; D000069448:Denosumab / Q000009:adverse effects*; D004164:Diphosphonates; D006801:Humans; D007568:Jaw; D009369:Neoplasms; D014081:Tooth Extraction
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D000069448:Denosumab