title: Primary bilateral corneal nerve sheath neoplasm in a dog.
abstract: A 15-year-old, neutered male, Shih Tzu cross developed progressive corneal stromal thickening and vascularization of the right eye, and 5 months later, of the left eye. Both eyes became blind due to extensive corneal opacification and were enucleated. Light microscopic examination revealed a diffuse corneal infiltrate of neoplastic mesenchymal cells, and immunohistochemistry revealed diffuse cytoplasmic vimentin immunoreactivity and variable cytoplasmic and nuclear immunoreactivity for S100 in the neoplastic cells. Transmission electron microscopy revealed desmosomes between contiguous cells, thread-like cytoplasmic processes coated with basement membrane, extracellular bundles of collagen, and axonal degeneration consistent with features of a nerve sheath neoplasm. This is the first report of primary, bilateral corneal nerve sheath sarcoma in a canine.
authors.affiliation: Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK, S7N 5B4, Canada.
authors.forename: Marina L
authors.initials: ML
authors.lastname: Leis
authors.affiliation: Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK, S7N 5B4, Canada.
authors.forename: M Elyse
authors.initials: ME
authors.lastname: Salpeter
authors.affiliation: Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK, S7N 5B4, Canada.
authors.forename: Bianca S
authors.initials: BS
authors.lastname: Bauer
authors.affiliation: Prairie Diagnostic Services, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK, S7N 5B4, Canada.
authors.forename: Dale L
authors.initials: DL
authors.lastname: Godson
authors.affiliation: Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK, S7N 5B4, Canada.
authors.forename: Bruce H
authors.initials: BH
authors.lastname: Grahn
mesh_terms: D000818:Animals; D003315:Cornea; D003319:Corneal Stroma / Q000473:pathology; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005134:Eye Neoplasms / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*; D007150:Immunohistochemistry / Q000662:veterinary; D008297:Male; D009363:Neoplasm Proteins / Q000032:analysis; D018317:Nerve Sheath Neoplasms / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*; D014746:Vimentin / Q000032:analysis
chemical_list: D009363:Neoplasm Proteins; D014746:Vimentin
keywords: canine; corneal neoplasia; electron microscopy; histopathology; immunohistochemistry; nerve sheath neoplasm