title: CD34(+) therapy-related acute promyelocytic leukemia in a patient previously treated for breast cancer.
abstract: Therapy-related acute myeloid leukemia (AML) is a long term complication of chemotherapy for a variety of cancers. In most cases, the marrow demonstrates high risk cytogenetics and the prognosis is poor. In a minority of patients "good risk" cytogenetics, including t(15;17)(q22;q12), are seen and the patient's prognosis is similar to those who have de novo disease. Currently we present a patient who developed therapy-related acute promyelocytic leukemia (APL) after chemoradiotherapy for breast cancer. This case was especially atypical because the leukemic cells were CD34(+), which is an unusual immunophenotype for APL. Recognition that this patient had APL, rather than the more common therapy-related MDS or AML, was imperative to initiate chemotherapy in a timely manner.
authors.affiliation: 1 Department of Medicine, New York Medical College, Valhalla, NY, USA ; 2 Department of Pathology, Westchester Medical Center, Valhalla, NY, USA.
authors.forename: John
authors.initials: J
authors.lastname: Savooji
authors.affiliation: 1 Department of Medicine, New York Medical College, Valhalla, NY, USA ; 2 Department of Pathology, Westchester Medical Center, Valhalla, NY, USA.
authors.forename: Fouzia
authors.initials: F
authors.lastname: Shakil
authors.affiliation: 1 Department of Medicine, New York Medical College, Valhalla, NY, USA ; 2 Department of Pathology, Westchester Medical Center, Valhalla, NY, USA.
authors.forename: Humayun
authors.initials: H
authors.lastname: Islam
authors.affiliation: 1 Department of Medicine, New York Medical College, Valhalla, NY, USA ; 2 Department of Pathology, Westchester Medical Center, Valhalla, NY, USA.
authors.forename: Delong
authors.initials: D
authors.lastname: Liu
authors.affiliation: 1 Department of Medicine, New York Medical College, Valhalla, NY, USA ; 2 Department of Pathology, Westchester Medical Center, Valhalla, NY, USA.
authors.forename: Karen
authors.initials: K
authors.lastname: Seiter
keywords: Acute promyelocytic leukemia (APL); CD34+; breast cancer; therapy-related leukemia