title: Incidence of Infection and Inhospital Mortality in Patients With Chronic Renal Failure After Total Joint Arthroplasty.
abstract: Patients with chronic renal failure (CRF) may require total joint arthroplasty (TJA) to treat degenerative joint disease, fractures, osteonecrosis, or amyloid arthropathy. There have been conflicting results, however, regarding outcomes of TJA in patients with chronic renal disease. The aim of this case-controlled study was to determine the outcome of TJA in patients with CRF, with particular interest in the incidence of infections and inhospital mortality.
  
  
  
  We queried our electronic database to determine which patients among the 29,389 TJAs performed at our institution between January 2000 and June 2012 had a diagnosis of CRF. A total of 359 CRF patients were identified and matched for procedure, gender, age (±4 years), date of surgery (±2 years), and body mass index (±5 kg/m2) in a 2:1 ratio to 718 control patients.
  
  
  
  The incidence of infection and inhospital mortality was not significantly different between the nondialysis CRF patients and controls, whereas it was significantly higher in dialysis-dependent end-stage renal failure patients compared to controls. Of the 50 CRF patients receiving hemodialysis, 10 (20%) developed surgical site infection, of which 4 (8%) were periprosthetic joint infection, and 4 (8%) died during hospital stay. The odds ratio for infection in the dialysis group was 7.54 (95% confidence interval: 2.83-20.12) and 10.46 (95% confidence interval: 1.67-65.34) for the inhospital mortality.
  
  
  
  We conclude that end-stage renal failure patients receiving hemodialysis have higher postoperative infection and inhospital mortality rates after an elective TJA procedure, whereas nondialysis CRF patients have similar outcomes compared with the general TJA population.
authors.affiliation: Rothman Institute at Thomas Jefferson University, Philadelphia, Pennsylvania.
authors.forename: Omer F
authors.initials: OF
authors.lastname: Erkocak
authors.affiliation: Rothman Institute at Thomas Jefferson University, Philadelphia, Pennsylvania.
authors.forename: Joanne Y
authors.initials: JY
authors.lastname: Yoo
authors.affiliation: Rothman Institute at Thomas Jefferson University, Philadelphia, Pennsylvania.
authors.forename: Camilo
authors.initials: C
authors.lastname: Restrepo
authors.affiliation: Rothman Institute at Thomas Jefferson University, Philadelphia, Pennsylvania.
authors.forename: Mitchell G
authors.initials: MG
authors.lastname: Maltenfort
authors.affiliation: Rothman Institute at Thomas Jefferson University, Philadelphia, Pennsylvania.
authors.forename: Javad
authors.initials: J
authors.lastname: Parvizi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects / Q000401:mortality*; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects / Q000401:mortality*; D002648:Child; D016208:Databases, Factual; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000401:mortality*; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D015143:Philadelphia / Q000453:epidemiology; D016459:Prosthesis-Related Infections / Q000453:epidemiology* / Q000209:etiology; D006435:Renal Dialysis; D012189:Retrospective Studies; D013530:Surgical Wound Infection / Q000453:epidemiology* / Q000209:etiology; D055815:Young Adult
keywords: chronic renal failure; hemodialysis; in-hospital mortality; infection; renal disease; total joint arthroplasty