title: [Role of Biology Based on Epigenetics in Multiple Myeloma].
abstract: Multiple myeloma (MM) is a malignant tumor, characterized by dysplasia of clonal plasma cells in the bone marrow secreting large amounts of monoclonal immunoglobulin or fragments (M protein), resulting in damage in relevant organs or tissues. The biological complexity of MM is based on disrupted cancer pathways. Except the central role of cytogenetic abnormalities, epigenetic aberrations have also been shown to be involved in the occurrence and development of MM. Epigenetics of MM is mainly concentrated in the ways of DNA methylation, histone modifications and noncoding RNA, which have generated abnormal signaling pathways to regulate cell cycle and apoptosis of MM. In this article, advances of research on epigenetics of development, clinical diagnosis and treatments of MM are reviewed.
authors.affiliation: Hematology Center of Chinese People's Liberation Army, Lanzhou General Hospital of Lanzhou Military Command, Lanzhou 730050, Gansu Province, China.|College of Clinical Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, Gansu Province, China.
authors.forename: Bin-Bin
authors.initials: BB
authors.lastname: Wang
authors.affiliation: Hematology Center of Chinese People's Liberation Army, Lanzhou General Hospital of Lanzhou Military Command, Lanzhou 730050, Gansu Province, China. E-mail: wutao2009@126.com.
authors.forename: Tao
authors.initials: T
authors.lastname: Wu
mesh_terms: D017209:Apoptosis; D001853:Bone Marrow / Q000378:metabolism; D002453:Cell Cycle; D002869:Chromosome Aberrations; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D006801:Humans; D009101:Multiple Myeloma / Q000235:genetics*; D009194:Myeloma Proteins / Q000378:metabolism; D010950:Plasma Cells / Q000166:cytology; D015398:Signal Transduction
chemical_list: D009194:Myeloma Proteins; C085016:multiple myeloma M-proteins