title: Genome wide association study on beef production traits in Marchigiana cattle breed.
abstract: A genomewide association study was carried out on a sample of Marchigiana breed cattle to detect markers significantly associated with carcass and meat traits. Four hundred and nine young bulls from 117 commercial herds were genotyped by Illumina 50K BeadChip assay. Eight growth and carcass traits (average daily gain, carcass weight, dressing percentage, body weight, skin weight, shank circumference, head weight and carcass conformation) and two meat quality traits (pH at slaughter and pH 24 h after slaughter) were measured. Data were analysed with a linear mixed model that included fixed effects of herd, slaughter date, fixed covariables of age at slaughter and SNP genotype, and random effects of herd and animal. A permutation test was performed to correct SNP genotype significance level for multiple testing. A total of 96 SNPs were significantly associated at genomewide level with one or more of the considered traits. Gene search was performed on genomic regions identified on the basis of significant SNP position and level of linkage disequilibrium. Interesting loci affecting lipid metabolism (SOAT1), bone (BMP4) and muscle (MYOF) biology were highlighted. These results may be useful to better understand the genetic architecture of growth and body composition in cattle.
authors.affiliation: Dipartimento di Agraria, Sezione di Scienze Zootecniche, Università degli Studi di Sassari, Sassari, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Sorbolini
authors.affiliation: Dipartimento per l'Innovazione nei Sistemi Biologici Agroalimentari e Forestali DIBAF, Università della Tuscia, Viterbo, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Bongiorni
authors.affiliation: Dipartimento di Agraria, Sezione di Scienze Zootecniche, Università degli Studi di Sassari, Sassari, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Cellesi
authors.affiliation: Dipartimento di Agraria, Sezione di Scienze Zootecniche, Università degli Studi di Sassari, Sassari, Italy.
authors.forename: G
authors.identifier: http://orcid.org/0000-0003-1604-8917
authors.initials: G
authors.lastname: Gaspa
authors.affiliation: Dipartimento di Agraria, Sezione di Scienze Zootecniche, Università degli Studi di Sassari, Sassari, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Dimauro
authors.affiliation: Dipartimento per l'Innovazione nei Sistemi Biologici Agroalimentari e Forestali DIBAF, Università della Tuscia, Viterbo, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Valentini
authors.affiliation: Dipartimento di Agraria, Sezione di Scienze Zootecniche, Università degli Studi di Sassari, Sassari, Italy.
authors.forename: N P P
authors.initials: NP
authors.lastname: Macciotta
mesh_terms: D000818:Animals; D049628:Body Size; D001835:Body Weight; D002417:Cattle / Q000145:classification / Q000235:genetics* / Q000254:growth & development*; D008297:Male; D008460:Meat; D020641:Polymorphism, Single Nucleotide
keywords: Bovine; SNP chip; genomewide association studies; productive traits