title: Impact of opportunistic salpingectomy on anti-Müllerian hormone in patients undergoing laparoscopic hysterectomy: a multicentre randomised controlled trial.
abstract: OBJECTIVE
  The aim of the study was to investigate whether opportunistic salpingectomy has any deleterious effects on ovarian reserve and increases surgical risk in patients undergoing laparoscopic hysterectomy.
  
  
  METHODS
  A multicentre, randomised controlled trial.
  
  
  METHODS
  Three university hospitals in Korea.
  
  
  METHODS
  Sixty-eight patients undergoing laparoscopic hysterectomy for the treatment of symptomatic benign uterine diseases.
  
  
  METHODS
  Patients were randomised to undergo either opportunistic salpingectomy (n = 34) or no salpingectomy (n = 34) during laparoscopic hysterectomy.
  
  
  METHODS
  The primary and secondary outcome measures were the change of ovarian reserve, determined by the rate of decline in anti-Müllerian hormone (AMH) level from before surgery to 3 months post-surgery and surgical outcomes, respectively.
  
  
  RESULTS
  Baseline demographic and clinical characteristics were similar between the two groups. There was also no difference in operative outcomes such as operative time, operative bleeding, or complications between the two groups. In both groups, postoperative AMH levels were significantly lower than preoperative AMH levels (both, P < 0.01). The decline rate in AMH was 12.5% (interquartile range 0.8-60.9%) in the opportunistic salpingectomy group and 10.8% (interquartile range 6.9-27.4%) in the no salpingectomy group, with no significant difference between both groups (P = 0.898).
  
  
  CONCLUSIONS
  Opportunistic salpingectomy at the time of laparoscopic hysterectomy did not have any negative effects on ovarian reserve or increased surgical risk.
  
  
  CONCLUSIONS
  Opportunistic salpingectomy did not have any negative effects on ovarian reserve or increased surgical risk.
authors.affiliation: Department of Obstetrics & Gynaecology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: T
authors.initials: T
authors.lastname: Song
authors.affiliation: Department of Obstetrics & Gynaecology, CHA Gangnam Medical Centre, CHA University, Seoul, Korea.
authors.forename: M K
authors.initials: MK
authors.lastname: Kim
authors.affiliation: Department of Obstetrics & Gynaecology, CHA Gangnam Medical Centre, CHA University, Seoul, Korea.
authors.forename: M-L
authors.initials: ML
authors.lastname: Kim
authors.affiliation: Department of Obstetrics & Gynaecology, CHA Gangnam Medical Centre, CHA University, Seoul, Korea.
authors.forename: Y W
authors.initials: YW
authors.lastname: Jung
authors.affiliation: Department of Obstetrics & Gynaecology, CHA Gangnam Medical Centre, CHA University, Seoul, Korea.
authors.forename: B S
authors.initials: BS
authors.lastname: Yun
authors.affiliation: Department of Obstetrics & Gynaecology, CHA Gangnam Medical Centre, CHA University, Seoul, Korea.
authors.forename: S J
authors.initials: SJ
authors.lastname: Seong
authors.affiliation: Department of Obstetrics & Gynaecology, Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea.
authors.forename: S-H
authors.initials: SH
authors.lastname: Kwon
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects* / Q000379:methods; D010535:Laparoscopy / Q000009:adverse effects* / Q000379:methods; D008875:Middle Aged; D065851:Ovarian Reserve / Q000502:physiology; D011184:Postoperative Period; D057234:Preoperative Period; D011446:Prospective Studies; D056910:Republic of Korea; D058994:Salpingectomy / Q000009:adverse effects* / Q000379:methods; D016896:Treatment Outcome; D014591:Uterine Diseases / Q000097:blood / Q000503:physiopathology / Q000601:surgery*
chemical_list: D054304:Anti-Mullerian Hormone
keywords: Anti-Müllerian hormone; hysterectomy; ovarian cancer; ovarian reserve; salpingectomy