title: Adults at Increased Alzheimer's Disease Risk Display Cognitive-Motor Integration Impairment Associated with Changes in Resting-State Functional Connectivity: A Preliminary Study.
abstract: Many neuroimaging parameters have demonstrated utility as biomarkers in preclinical AD, including resting-state functional connectivity in the default mode network. However, neuroimaging is not a practical, cost effective screening instrument.
  
  
  
  Here we investigate the relationship between performance on a cognitive-motor integration assessment and alterations in resting-state functional connectivity in an at-risk population.
  
  
  
  Three groups of ten adults (young: mean age = 26.6 ± 2.7, low AD risk: mean age = 58.7 ± 5.6, and high AD risk: mean age = 58.5 ± 6.9) performed a simple cognitive-motor integration task using a dual-touchscreen laptop and also underwent functional magnetic resonance imaging at rest.
  
  
  
  We found poorer cognitive-motor integration performance in high AD risk participants, as well as an association with lower resting-state functional connectivity in this group.
  
  
  
  These findings provide novel insight into underlying AD-related brain alterations associated with a behavioral assessment that can be easily administered clinically.
authors.forename: Kara M
authors.initials: KM
authors.lastname: Hawkins
authors.forename: Lauren E
authors.initials: LE
authors.lastname: Sergio
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000544:Alzheimer Disease / Q000150:complications*; D000704:Analysis of Variance; D001696:Biomechanical Phenomena; D060825:Cognitive Dysfunction / Q000000981:diagnostic imaging* / Q000209:etiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008959:Models, Neurological; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D010775:Photic Stimulation; D011597:Psychomotor Performance / Q000502:physiology*; D011930:Reaction Time; D012146:Rest; D012307:Risk Factors; D055815:Young Adult
chemical_list: D010100:Oxygen
keywords: Aging; ApoE4; dementia; functional magnetic resonance imaging; geriatric assessment; population at risk; psychomotor performance