title: Dehydroepiandrosterone, Its Sulfate and Cognitive Functions.
abstract: To present a review of cross-sectional and longitudinal studies that investigate the relationship between the hormones Dehydroepiandrosterone (DHEA) and Dehydroepiandrosterone sulfate (DHEA-S) and cognition.
  
  
  METHODS
  The cognition items included in this review were global cognitive function, memory, attention, executive function, intelligence, perception and visuospatial ability. A systematic review was proceeded using three databases: PubMed, ISI Web of Science, and PsycINFO.
  
  
  RESULTS
  Two thousand fifty five references about cognition and hormones were found; 772 duplicated references were excluded, resulting in 1.283 references to be evaluated. According to exclusion and inclusion criteria, 25 references were selected. A positive correlation between DHEA-S blood levels and global cognition was found in women and men. Other positive correlations between DHEA-S and working memory, attention and verbal fluency were found only in women. The DHEA effect on cognition is limited to one study conducted among young men with high-doses.
authors.affiliation: Laboratory of Panic and Respiration, Institute of Psychiatry, UFRJ (Federal University of Rio de Janeiro), Brazil.
authors.forename: Karina Junqueira
authors.initials: KJ
authors.lastname: de Menezes
authors.affiliation: Laboratory of Panic and Respiration, Institute of Psychiatry, UFRJ (Federal University of Rio de Janeiro), Brazil.
authors.forename: Clayton
authors.initials: C
authors.lastname: Peixoto
authors.affiliation: Laboratory of Panic and Respiration, Institute of Psychiatry, UFRJ (Federal University of Rio de Janeiro), Brazil.
authors.forename: Antonio Egidio
authors.initials: AE
authors.lastname: Nardi
authors.affiliation: Department of Public Health, Clinical and Molecular Medicine, University of Cagliari, Cagliari, Italy.
authors.forename: Mauro Giovanni
authors.initials: MG
authors.lastname: Carta
authors.affiliation: Laboratory of Panic and Respiration, Institute of Psychiatry, UFRJ (Federal University of Rio de Janeiro), Brazil.
authors.forename: Sérgio
authors.initials: S
authors.lastname: Machado
authors.affiliation: Dom Bosco Catholic University (UCDB), Laboratory of Panic and Respiration, Institute of Psychiatry, UFRJ, Brazil.
authors.forename: André Barciela
authors.initials: AB
authors.lastname: Veras
keywords: Attention; Cognition; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Executive Function; Memory; Neuropsychology