title: The Level of Cholesterol in COPD Patients with Severe and Very Severe Stage of the Disease.
abstract: BACKGROUND
  High blood cholesterol is part of metabolic syndrome and can be caused by medical conditions or bad dietary habits.
  
  
  OBJECTIVE
  The aim of the study was to investigate the prevalence of hypercholesterolemia in privies diagnosed patients with the severe and very severe stage of COPD, which were stable.
  
  
  METHODS
  We investigated 100 subjects, all of them smokers, with smoking status >10 years, stratified into two groups: with severe and very severe stage of the disease. It was clinical, randomized, cross-sectional study. Besides demographic parameters and functional parameters, body mass index, cholesterol, LDL, and HDL were investigated.
  
  
  RESULTS
  In the group of patients with very severe COPD were recorded significantly higher average values of cholesterol (6.16 ± 1.5 vs. 5.61 ± 1.1, p = 0.039). As independent significant factors influencing cholesterol in the group with a very severe COPD were confirmed the age of the patients (p = 0.005), LDL (p = 0.004) and HDL (p = 0.002). In the group with severe COPD, only LDL was confirmed as an independent significant factor that has an impact on cholesterol (p < 0.0001).
  
  
  CONCLUSIONS
  The results of our survey demonstrated a high level of blood cholesterol and LDL, and low level of blood HDL in both investigated group's patients with COPD.
authors.affiliation: Institute for Epidemiology and Biostatistics and Medical Informatics, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
authors.forename: Beti
authors.initials: B
authors.lastname: Zafirova-Ivanovska
authors.affiliation: University Clinic of Pulmonology and Allergology, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
authors.forename: Jagoda
authors.initials: J
authors.lastname: Stojkovikj
authors.affiliation: University Clinic of Pulmonology and Allergology, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
authors.forename: Dejan
authors.initials: D
authors.lastname: Dokikj
authors.affiliation: University Clinic of Cardiology, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
authors.forename: Sasha
authors.initials: S
authors.lastname: Anastasova
authors.affiliation: University Clinic of Pulmonology and Allergology, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
authors.forename: Angela
authors.initials: A
authors.lastname: Debresliovska
authors.affiliation: University Clinic of Pulmonology and Allergology, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
authors.forename: Sead
authors.initials: S
authors.lastname: Zejnel
authors.affiliation: School of Doctoral Studies at Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
authors.forename: Dragana
authors.initials: D
authors.lastname: Stojkovikj
keywords: comorbidity; severe and very severe COPD; the level of HDL; the level of LDL; the level of cholesterol