title: Association of serum levels of AngII, KLK1, and ACE/KLK1 polymorphisms with acute myocardial infarction induced by coronary artery stenosis.
abstract: BACKGROUND
  The study aims to confirm the association of acute myocardial infarction (AMI) with serum angiotensin II (AngII), kallikrein1 (KLK1), and ACE/KLK1 polymorphisms.
  
  
  METHODS
  Serum AngII/KLK1 levels and ACE and KLK1 genotypes were determined in 208 patients with AMI and 216 normal controls. Binary logistic regression was used for data analysis.
  
  
  RESULTS
  The differences in serum AngII levels were statistically significant between the groups. After adjusting for potential confounding factors, high serum levels of AngII and KLK1 significantly increased the risk of AMI. The individuals with ACE DD and KLK1 GG genotypes significantly increased the risk of AMI compared with those harboring the ACE II and KLK1 AA genotypes (OR = 8.77, 95% CI = 1.74-44.16).
  
  
  CONCLUSIONS
  (1) Increasing the serum levels of AngII increased the risk of AMI. (2) The risk of AMI increased significantly when the serum levels of AngII and KLK1 simultaneously increased. (3) Individuals with the combined genotypes of ACE DD and KLK1 GG showed significantly increased risk of AMI compared with those with the combined genotypes of ACE II and KLK1 AA.
authors.affiliation: The Key Laboratory of Cardiovascular Remodelling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, China Department of cardiology, Qilu Hospital, Shandong University, China.
authors.forename: Shu-hong
authors.initials: SH
authors.lastname: Dai
authors.affiliation: The Key Laboratory of Cardiovascular Remodelling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, China Department of cardiology, Qilu Hospital, Shandong University, China.
authors.forename: Ji-fu
authors.initials: JF
authors.lastname: Li
authors.affiliation: Department of obstetrics and gynecology, Qilu Hospital, Shandong University, China.
authors.forename: Jin-bo
authors.initials: JB
authors.lastname: Feng
authors.affiliation: Department of emergency, Qilu Hospital, Shandong University, China.
authors.forename: Rui-jian
authors.initials: RJ
authors.lastname: Li
authors.affiliation: Department of emergency, Qilu Hospital, Shandong University, China.
authors.forename: Chuan-bao
authors.initials: CB
authors.lastname: Li
authors.affiliation: The Key Laboratory of Cardiovascular Remodelling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, China Department of cardiology, Qilu Hospital, Shandong University, China.
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Li
authors.affiliation: The Key Laboratory of Cardiovascular Remodelling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, China Department of cardiology, Qilu Hospital, Shandong University, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: The Key Laboratory of Cardiovascular Remodelling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, China Department of cardiology, Qilu Hospital, Shandong University, China qingdali611@163.com.
authors.forename: Da-qing
authors.initials: DQ
authors.lastname: Li
mesh_terms: D000804:Angiotensin II / Q000097:blood*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D023921:Coronary Stenosis / Q000097:blood / Q000150:complications*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D054643:INDEL Mutation / Q000235:genetics; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000209:etiology* / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D020840:Tissue Kallikreins / Q000097:blood* / Q000235:genetics*
chemical_list: D000804:Angiotensin II; C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A; D020840:Tissue Kallikreins
keywords: Coronary artery stenosis; acute myocardial infarction; angiotensin converting enzyme gene; kallikrein1 gene; polymorphism