title: Risk of neuroblastoma, birth-related characteristics, congenital malformations and perinatal exposures: A pooled analysis of the ESCALE and ESTELLE French studies (SFCE).
abstract: Neuroblastoma (NB), an embryonic tumour arising from neural crest cells, is the most common malignancy among infants. The aetiology of NB is largely unknown. We conducted a pooled analysis to explore whether there is an association between NB and preconception and perinatal factors using data from two French national population-based case-control studies. The mothers of 357 NB cases and 1783 controls younger than 6 years, frequency-matched by age and gender, responded to a telephone interview that focused on demographic, socioeconomic and perinatal characteristics, childhood environment, life-style and maternal reproductive history. Unconditional logistic regression was used to estimate pooled odds ratios and 95% confidence intervals. After controlling for matching variables, study of origin and potential confounders, being born either small (OR 1.4 95% CI 1.0-2.0) or large (OR 1.5 95% CI 1.1-2.2) for gestational age and, among children younger than 18 months, having congenital malformations (OR 3.6 95% CI 1.3-8.9), were significantly associated with NB. Inverse associations were observed with breastfeeding (OR 0.7 95% CI 0.5-1.0) and maternal use of any supplements containing folic acid, vitamins or minerals (OR 0.5 95% CI 0.3-0.9) during the preconception period. Our findings reinforce the hypothesis that fetal growth anomalies and congenital malformations may be associated with an increased risk of NB. Further investigations are needed in order to clarify the role of folic acid supplementation and breastfeeding, given their potential importance in NB prevention.
authors.affiliation: Inserm U1153, Epidemiology and Biostatistics Sorbonne Paris Cité Centre (CRESS), Epidemiology of Childhood and Adolescent Cancers Team (EPICEA), Villejuif, France.|Paris-Descartes University, UMRS-1153, Epidemiology and Biostatistics Sorbonne Paris Cité Centre (CRESS), Paris, France.
authors.forename: Paula
authors.initials: P
authors.lastname: Rios
authors.affiliation: Inserm U1153, Epidemiology and Biostatistics Sorbonne Paris Cité Centre (CRESS), Epidemiology of Childhood and Adolescent Cancers Team (EPICEA), Villejuif, France.|Paris-Descartes University, UMRS-1153, Epidemiology and Biostatistics Sorbonne Paris Cité Centre (CRESS), Paris, France.
authors.forename: Helen D
authors.initials: HD
authors.lastname: Bailey
authors.affiliation: Inserm U1153, Epidemiology and Biostatistics Sorbonne Paris Cité Centre (CRESS), Epidemiology of Childhood and Adolescent Cancers Team (EPICEA), Villejuif, France.|Paris-Descartes University, UMRS-1153, Epidemiology and Biostatistics Sorbonne Paris Cité Centre (CRESS), Paris, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Orsi
authors.affiliation: Inserm U1153, Epidemiology and Biostatistics Sorbonne Paris Cité Centre (CRESS), Epidemiology of Childhood and Adolescent Cancers Team (EPICEA), Villejuif, France.|Paris-Descartes University, UMRS-1153, Epidemiology and Biostatistics Sorbonne Paris Cité Centre (CRESS), Paris, France.|CHU Nancy, Registre National Des Tumeurs Solides De L'Enfant, Vandœuvre-lès-Nancy, France.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Lacour
authors.affiliation: Gustave Roussy, Service D'Oncologie Pédiatrique, Paris, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Valteau-Couanet
authors.affiliation: Institut Curie, Département D'Oncologie Pédiatrique, Adolescents Et Jeunes Adultes, Paris, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Levy
authors.affiliation: Centre Léon Bérard, Institut D'Hématologie Et D'Oncologie Pédiatrique, Lyon, France.
authors.forename: Nadège
authors.initials: N
authors.lastname: Corradini
authors.affiliation: Hôpital Armand-Trousseau, Assistance Publique - Hôpitaux De Paris, Service D'Oncohématologie Pédiatrique, Paris, France.
authors.forename: Guy
authors.initials: G
authors.lastname: Leverger
authors.affiliation: Centre Oscar Lambret, Service D'Oncologie Pédiatrique, Lille, France.
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Defachelles
authors.affiliation: Hôpital Des Enfants, Sce D'Hématologie Oncologie Pédiatrique, Toulouse, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Gambart
authors.affiliation: Service d'Hémato-Oncologie Pédiatrique, Hôpital Arnaud De Villeneuve, Montpellier, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Sirvent
authors.affiliation: Hôpital De La Mère Et L'enfant, Service D'Oncologie Pédiatrique, Nantes, France.
authors.forename: Estelle
authors.initials: E
authors.lastname: Thebaud
authors.affiliation: Service D'Oncohématologie Pédiatrique, Hôpital Pellegrin Tripode, Bordeaux, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Ducassou
authors.affiliation: Inserm U1153, Epidemiology and Biostatistics Sorbonne Paris Cité Centre (CRESS), Epidemiology of Childhood and Adolescent Cancers Team (EPICEA), Villejuif, France.|Paris-Descartes University, UMRS-1153, Epidemiology and Biostatistics Sorbonne Paris Cité Centre (CRESS), Paris, France.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Clavel
mesh_terms: D000293:Adolescent; D000328:Adult; D001724:Birth Weight; D001942:Breast Feeding; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D000013:Congenital Abnormalities / Q000453:epidemiology*; D019587:Dietary Supplements / Q000706:statistics & numerical data*; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007407:Interviews as Topic; D016015:Logistic Models; D008297:Male; D009447:Neuroblastoma / Q000453:epidemiology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology* / Q000209:etiology; D055815:Young Adult
keywords: childhood cancer; congenital malformations; fetal growth; neuroblastoma; risk factors