title: Diagnostic efficacy and therapeutic impact of computed tomography in the evaluation of clinically suspected otosclerosis.
abstract: OBJECTIVE
  To assess the diagnostic efficacy and therapeutic impact of CT in evaluating patients with clinically suspected otosclerosis.
  
  
  METHODS
  CT scans performed over a 5-year period for clinically suspected otosclerosis were retrospectively reviewed. CT diagnoses were correlated with subsequent surgical management. For otosclerosis positive cases, clinically significant extensions of otosclerosis were correlated with audiometry and the diagnosis was correlated with surgical findings.
  
  
  RESULTS
  Of 259 CT studies, 46 % of patients were positive, 49 % negative and 5 % equivocal for otosclerosis. A relevant alternative CT diagnosis was evident in 33 % of the negative studies. One targeted surgery was performed for every four CT studies. CT outcome influenced the decision to perform stapedectomy in 41 % CT-positive versus 4 % CT-negative patients. CT-positive ears for otosclerosis could not be predicted from baseline clinical or audiometric criteria. Those with endosteal extension demonstrated lower bone conduction thresholds presurgically. The positive predictive value of CT diagnosis of otosclerosis was 100 %.
  
  
  CONCLUSIONS
  CT demonstrated a high rate of clinically relevant diagnoses in both CT-positive and -negative for otosclerosis patients, and this frequently influenced surgical management. CT also added value by demonstrating relevant extensions of the otosclerotic foci, some of which were predictive of audiometric parameters.
  
  
  CONCLUSIONS
  • CT demonstrates a high rate of alternative diagnoses in suspected otosclerosis, 1:3. • CT results in a high rate of targeted surgery in suspected otosclerosis, 1:4. • CT prevents exploratory surgery in suspected otosclerosis. • Endosteal extension of otosclerosis is predictive of lower bone conduction tresholds presurgically. • The PPV of CT diagnosis of otosclerosis was 100 %.
authors.affiliation: Department of Neuroradiology, King's College Hospital NHS Foundation Trust, Ruskin Wing, Denmark Hill, London, SE5 9RS, UK. cristinadudau@doctors.org.uk.
authors.forename: Cristina
authors.initials: C
authors.lastname: Dudau
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Auditory Implantation Centre, Guy's and St. Thomas Hospital, London, UK.
authors.forename: Fakhruddin
authors.initials: F
authors.lastname: Salim
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Auditory Implantation Centre, Guy's and St. Thomas Hospital, London, UK.
authors.forename: Dan
authors.initials: D
authors.lastname: Jiang
authors.affiliation: Department of Radiology, Guy's and St Thomas' NHS Foundation Trust, London, UK.
authors.forename: Steve E J
authors.initials: SE
authors.lastname: Connor
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001299:Audiometry; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010040:Otosclerosis / Q000000981:diagnostic imaging* / Q000601:surgery; D015203:Reproducibility of Results; D012189:Retrospective Studies; D013199:Stapes / Q000000981:diagnostic imaging; D013201:Stapes Surgery; D014057:Tomography, X-Ray Computed / Q000379:methods*; D055815:Young Adult
keywords: CT; Diagnosis; Efficacy; Otosclerosis; Stapedectomy