title: Expression of HSP27 in Hepatocellular Carcinoma.
abstract: OBJECTIVE
  Heat-shock protein 27 (HSP27), a low molecular weight stress protein, is recognized as a molecular chaperone. The expression of HSP27 has been detected in some human tumors and while HSP27 is phosphorylated as a reresponse to stress, the function of phosphorylated HSP27 (p-HSP27) is not known. The aim of this study was to investigate what kind of effect expression of HSP27 and p-HSP27 in HCC has on clinicopathological characteristics and prognosis.
  
  
  METHODS
  An immunohistochemical study for HSP27 and p-HSP27 was performed on 194 resected HCC cases. We analyzed the correlation of HSP27 expression with various parameters statistically.
  
  
  RESULTS
  There was no correlation between expression of HSP27 and the clinicopathological characteristics and prognosis from the analysis of 194 cases. From the analysis of the hepatitis C virus (HCV)-positive group of 142 cases, those that were p-HSP27-positive had a larger tumor diameter and the portal vein invasion rate was high.
  
  
  CONCLUSIONS
  The expression of total HSP27 may serve as a new, clinically useful marker of HCC. In addition, the present study suggests that the expression of phosphorylated HSP27 is useful in the screening and grading of HCC occurring in the setting of HCV.
authors.affiliation: Department of Surgery, School of Medicine, Kurume University, Kurume, Japan.
authors.forename: Daimei
authors.initials: D
authors.lastname: Eto
authors.affiliation: Department of Surgery, School of Medicine, Kurume University, Kurume, Japan thisaka@med.kurume-u.ac.jp.
authors.forename: Toru
authors.initials: T
authors.lastname: Hisaka
authors.affiliation: Department of Surgery, School of Medicine, Kurume University, Kurume, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Horiuchi
authors.affiliation: Department of Surgery, School of Medicine, Kurume University, Kurume, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Uchida
authors.affiliation: Department of Surgery, School of Medicine, Kurume University, Kurume, Japan.
authors.forename: Hiroto
authors.initials: H
authors.lastname: Ishikawa
authors.affiliation: Department of Surgery, School of Medicine, Kurume University, Kurume, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kawashima
authors.affiliation: Department of Surgery, School of Medicine, Kurume University, Kurume, Japan.
authors.forename: Tetsushi
authors.initials: T
authors.lastname: Kinugasa
authors.affiliation: Department of Pathology, School of Medicine, Kurume University, Kurume, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Nakashima
authors.affiliation: Department of Pathology, School of Medicine, Kurume University, Kurume, Japan.
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Yano
authors.affiliation: Department of Surgery, School of Medicine, Kurume University, Kurume, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Okuda
authors.affiliation: Department of Surgery, School of Medicine, Kurume University, Kurume, Japan.
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Akagi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000821:virology; D005260:Female; D055551:HSP27 Heat-Shock Proteins / Q000378:metabolism*; D006360:Heat-Shock Proteins; D006526:Hepatitis C / Q000150:complications / Q000378:metabolism; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism* / Q000821:virology; D008297:Male; D008875:Middle Aged; D018832:Molecular Chaperones; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational
chemical_list: D014408:Biomarkers, Tumor; D055551:HSP27 Heat-Shock Proteins; C057725:HSPB1 protein, human; D006360:Heat-Shock Proteins; D018832:Molecular Chaperones
keywords: Heat-shock protein; Hepatocellular carcinoma; hepatectomy; hepatitis C virus; phosphorylation