title: Periostin and Interleukin-13 Are Independently Related to Chronic Spontaneous Urticaria.
abstract: Chronic spontaneous urticaria (CSU) is a complex idiopathic disease of the skin with various cellular infiltrations. Although mast cells are key effector cells in the pathogenesis of CSU, CD4+ T helper 2 cells also have particular roles in the development and maintenance of CSU. Periostin is known as a downstream molecule of interleukin (IL)-4 and IL-13, key cytokines of type 2 immune responses. In this study, we examined periostin and IL-13 levels in the sera of patients with CSU (n=84) and healthy normal controls (NCs, n=43). Periostin levels were significantly lower in the CSU group than in NCs (71.4±21.8 vs 85.1±22.4 ng/mL, P=0.04). Periostin levels were also lower in the severe CSU group than those in mild CSU (59.7±18.0 vs 73.4±22.0 ng/mL, P=0.04). However, IL-13 levels were significantly higher in patients with CSU than in NCs (508.5±51.2 vs 200.7±13.3 pg/mL, P=0.001). In conclusion, periostin and IL-13 may be independently related to the pathogenesis of CSU.
authors.affiliation: Department of Dermatology, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea.
authors.forename: Youin
authors.initials: Y
authors.lastname: Bae
authors.affiliation: Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Izuhara
authors.affiliation: Department of Laboratory Medicine, Saga Medical School, Saga, Japan.
authors.forename: Soichiro
authors.initials: S
authors.lastname: Ohta
authors.affiliation: The Shino-Test Corporation, Sagamihara, Japan.
authors.forename: Junya
authors.initials: J
authors.lastname: Ono
authors.affiliation: Department of Pharmacology and SBRI, Sungkyunkwan University School of Medicine, Suwon, Korea.
authors.forename: Gwan Ui
authors.initials: GU
authors.lastname: Hong
authors.affiliation: Department of Pharmacology and SBRI, Sungkyunkwan University School of Medicine, Suwon, Korea.
authors.forename: Jai Youl
authors.initials: JY
authors.lastname: Ro
authors.affiliation: Department of Dermatology, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea.
authors.forename: Gyeong Hun
authors.initials: GH
authors.lastname: Park
authors.affiliation: Department of Pulmonology and Allergy, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea. mdqueen@hallym.or.kr.
authors.forename: Jeong Hee
authors.initials: JH
authors.lastname: Choi
keywords: Urticaria; interleukin-13; periostin