title: Pulsatile Support Mode of BJUT-II Ventricular Assist Device (VAD) has Better Hemodynamic Effects on the Aorta than Constant Speed Mode: A Primary Numerical Study.
abstract: BACKGROUND BJUT-II VAD is a novel left ventricular assist device (LVADs), directly implanted into the ascending aorta. The pulsatile support mode is proposed to achieve better unloading performance than constant speed mode. However, the hemodynamic effects of this support mode on the aorta are still unclear. The aim of this study was to clarify the hemodynamic effects BJUT-II VAD under pulsatile support mode on the aorta. MATERIAL AND METHODS Computational fluid dynamics (CFD) studies, based on a patient-specific aortic geometric model, were conducted. Wall shear stress (WSS), averaged WSS (avWSS), oscillatory shear index (OSI), and averaged helicity density (Ha) were calculated to compare the differences in hemodynamic effects between pulsatile support mode and constant speed mode. RESULTS The results show that avWSS under pulsatile support mode is significantly higher than that under constant speed mode (0.955Pa vs. 0.675Pa). Similarly, the OSI value under pulsatile mode is higher than that under constant speed mode (0.104 vs. 0.057). In addition, Ha under pulsatile mode for all selected cross-sections is larger than that under constant mode. CONCLUSIONS BJUT-II VAD, under pulsatile control mode, may prevent atherosclerosis lesions and aortic remodeling. The precise effects of pulsatile support mode on atherosclerosis and aortic remodeling need to be further studied in animal experiments.
authors.affiliation: School of Life Sciences and BioEngineering, Beijing University of Technology, Beijing, China (mainland).
authors.forename: Kaiyun
authors.initials: K
authors.lastname: Gu
authors.affiliation: School of Life Sciences and BioEngineering, Beijing University of Technology, Beijing, China (mainland).
authors.forename: Bin
authors.initials: B
authors.lastname: Gao
authors.affiliation: School of Life Science and BioEngineering, Beijing University of Technology, Beijing, China (mainland).
authors.forename: Yu
authors.initials: Y
authors.lastname: Chang
authors.affiliation: School of Life Science and BioEngineering, Beijing University of Technology, Beijing, China (mainland).
authors.forename: Yi
authors.initials: Y
authors.lastname: Zeng
mesh_terms: D001011:Aorta / Q000502:physiology / Q000601:surgery; D003198:Computer Simulation; D006353:Heart-Assist Devices; D006439:Hemodynamics; D006801:Humans; D057446:Hydrodynamics; D008955:Models, Cardiovascular; D010865:Pilot Projects; D011474:Prosthesis Design; D011673:Pulsatile Flow / Q000502:physiology; D016277:Ventricular Function, Left / Q000502:physiology