title: Influenza A(H1N1)pdm09 virus exhibiting enhanced cross-resistance to oseltamivir and peramivir due to a dual H275Y/G147R substitution, Japan, March 2016.
abstract: An influenza A(H1N1)pdm09 virus carrying a G147R substitution in combination with an H275Y substitution in the neuraminidase protein, which confers cross-resistance to oseltamivir and peramivir, was detected from an immunocompromised inpatient in Japan, March 2016. This dual H275Y/G147R mutant virus exhibited enhanced cross-resistance to both drugs compared with the single H275Y mutant virus and reduced susceptibility to zanamivir, although it showed normal inhibition by laninamivir.
authors.affiliation: Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
authors.forename: Emi
authors.initials: E
authors.lastname: Takashita
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Fujisaki
authors.forename: Masayuki
authors.initials: M
authors.lastname: Shirakura
authors.forename: Kazuya
authors.initials: K
authors.lastname: Nakamura
authors.forename: Noriko
authors.initials: N
authors.lastname: Kishida
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kuwahara
authors.forename: Yukie
authors.initials: Y
authors.lastname: Shimazu
authors.forename: Takeshi
authors.initials: T
authors.lastname: Shimomura
authors.forename: Shinji
authors.initials: S
authors.lastname: Watanabe
authors.forename: Takato
authors.initials: T
authors.lastname: Odagiri
mesh_terms: D000146:Acids, Carbocyclic; D019943:Amino Acid Substitution / Q000235:genetics; D000998:Antiviral Agents / Q000008:administration & dosage; D003517:Cyclopentanes / Q000008:administration & dosage*; D024882:Drug Resistance, Viral; D004791:Enzyme Inhibitors / Q000008:administration & dosage; D005260:Female; D006146:Guanidines / Q000008:administration & dosage*; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics*; D007251:Influenza, Human / Q000188:drug therapy* / Q000821:virology*; D007564:Japan; D008875:Middle Aged; D009154:Mutation; D009439:Neuraminidase / Q000037:antagonists & inhibitors / Q000235:genetics; D053139:Oseltamivir / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000146:Acids, Carbocyclic; D000998:Antiviral Agents; D003517:Cyclopentanes; D004791:Enzyme Inhibitors; D006146:Guanidines; D053139:Oseltamivir; D009439:Neuraminidase; C414210:peramivir
keywords: A(H1N1)pdm09; influenza virus; neuraminidase inhibitor; oseltamivir-resistant influenza virus; peramivir-resistant influenza virus