title: Computationally Efficient Implementation of a Novel Algorithm for the General Unified Threshold Model of Survival (GUTS).
abstract: The General Unified Threshold model of Survival (GUTS) provides a consistent mathematical framework for survival analysis. However, the calibration of GUTS models is computationally challenging. We present a novel algorithm and its fast implementation in our R package, GUTS, that help to overcome these challenges. We show a step-by-step application example consisting of model calibration and uncertainty estimation as well as making probabilistic predictions and validating the model with new data. Using self-defined wrapper functions, we show how to produce informative text printouts and plots without effort, for the inexperienced as well as the advanced user. The complete ready-to-run script is available as supplemental material. We expect that our software facilitates novel re-analysis of existing survival data as well as asking new research questions in a wide range of sciences. In particular the ability to quickly quantify stressor thresholds in conjunction with dynamic compensating processes, and their uncertainty, is an improvement that complements current survival analysis methods.
authors.affiliation: Eawag: Swiss Federal Institute of Aquatic Science and Technology, Dübendorf, Switzerland.
authors.forename: Carlo
authors.initials: C
authors.lastname: Albert
authors.affiliation: Eawag: Swiss Federal Institute of Aquatic Science and Technology, Dübendorf, Switzerland.
authors.forename: Sören
authors.initials: S
authors.lastname: Vogel
authors.affiliation: Environment Department, University of York, Heslington, York, United Kingdom.
authors.forename: Roman
authors.identifier: 0000-0002-9579-8793
authors.initials: R
authors.lastname: Ashauer
mesh_terms: D000465:Algorithms; D019295:Computational Biology / Q000379:methods*; D006801:Humans; D008390:Markov Chains; D009010:Monte Carlo Method; D012984:Software; D016019:Survival Analysis