title: High Oxygen Delivery to Preserve Exercise Capacity in Patients with Idiopathic Pulmonary Fibrosis Treated with Nintedanib. Methodology of the HOPE-IPF Study.
abstract: Pulmonary rehabilitation improves dyspnea and exercise capacity in idiopathic pulmonary fibrosis (IPF); however, it is unknown whether breathing high amounts of oxygen during exercise training leads to further benefits.
  
  
  
  Herein, we describe the design of the High Oxygen Delivery to Preserve Exercise Capacity in IPF Patients Treated with Nintedanib study (the HOPE-IPF study). The primary objective of this study is to determine the physiological and perceptual impact of breathing high levels of oxygen during exercise training in patients with IPF who are receiving antifibrotic therapy.
  
  
  
  HOPE-IPF is a two-arm double-blind multicenter randomized placebo-controlled trial of 88 patients with IPF treated with nintedanib. Patients will undergo 8 weeks of three times weekly aerobic cycle exercise training, breathing a hyperoxic gas mixture with a constant fraction of 60% inhaled oxygen, or breathing up to 40% oxygen as required to maintain an oxygen saturation level of at least 88%.
  
  
  
  End points will be assessed at baseline, postintervention (Week 8), and follow-up (Week 26). The primary analysis will compare the between-group baseline with post-training change in endurance time during constant work rate cycle exercise tests. Additional analyses will evaluate the impact of training with high oxygen delivery on 6-minute walk distance, dyspnea, physical activity, and quality of life.
  
  
  
  The HOPE-IPF study will lead to a comprehensive understanding of IPF exercise physiology, with the potential to change clinical practice by indicating the need for increased delivery of supplemental oxygen during pulmonary rehabilitation in patients with IPF. Clinical trial registered with www.clinicaltrials.gov (NCT02551068).
authors.affiliation: 1 Department of Medicine.|2 Centre for Heart Lung Innovation, University of British Columbia and St. Paul's Hospital, Vancouver, British Columbia, Canada.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Ryerson
authors.affiliation: 3 Department of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada.|2 Centre for Heart Lung Innovation, University of British Columbia and St. Paul's Hospital, Vancouver, British Columbia, Canada.
authors.forename: Pat G
authors.initials: PG
authors.lastname: Camp
authors.affiliation: 4 Centre for Heart, Lung and Vascular Health, University of British Columbia, Kelowna, British Columbia, Canada.
authors.forename: Neil D
authors.initials: ND
authors.lastname: Eves
authors.affiliation: 3 Department of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada.|2 Centre for Heart Lung Innovation, University of British Columbia and St. Paul's Hospital, Vancouver, British Columbia, Canada.
authors.forename: Michele
authors.initials: M
authors.lastname: Schaeffer
authors.affiliation: 3 Department of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada.|2 Centre for Heart Lung Innovation, University of British Columbia and St. Paul's Hospital, Vancouver, British Columbia, Canada.
authors.forename: Nafeez
authors.initials: N
authors.lastname: Syed
authors.affiliation: 3 Department of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada.|2 Centre for Heart Lung Innovation, University of British Columbia and St. Paul's Hospital, Vancouver, British Columbia, Canada.
authors.forename: Satvir
authors.initials: S
authors.lastname: Dhillon
authors.affiliation: 5 Department of Kinesiology and Physical Education, McGill University; Division of Respiratory Medicine, Department of Medicine, McGill University and Research Institute of the McGill University Health Centre; and Centre for Innovative Medicine, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
authors.forename: Dennis
authors.initials: D
authors.lastname: Jensen
authors.affiliation: 6 Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Quebec City, Quebec, Canada.
authors.forename: Francois
authors.initials: F
authors.lastname: Maltais
authors.affiliation: 7 Division of Respiratory and Critical Care Medicine, Queen's University, Kingston, Ontario, Canada.
authors.forename: Denis E
authors.initials: DE
authors.lastname: O'Donnell
authors.affiliation: 8 Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Natya
authors.initials: N
authors.lastname: Raghavan
authors.affiliation: 9 Departments of Medicine and Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.
authors.forename: Michael
authors.initials: M
authors.lastname: Roman
authors.affiliation: 10 Pulmonary Division, Department of Medicine, University of Alberta and G. F. MacDonald Centre for Lung Health, Covenant Health, Edmonton, Alberta, Canada.
authors.forename: Michael K
authors.initials: MK
authors.lastname: Stickland
authors.affiliation: 11 Department of Medicine, McGill University, Montreal, Quebec, Canada.
authors.forename: Deborah
authors.initials: D
authors.lastname: Assayag
authors.affiliation: 12 Montreal Chest Institute, McGill University Health Centre, Montreal, Quebec, Canada.
authors.forename: Jean
authors.initials: J
authors.lastname: Bourbeau
authors.affiliation: 6 Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Quebec City, Quebec, Canada.
authors.forename: Genevieve
authors.initials: G
authors.lastname: Dion
authors.affiliation: 9 Departments of Medicine and Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.
authors.forename: Charlene D
authors.initials: CD
authors.lastname: Fell
authors.affiliation: 8 Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Nathan
authors.initials: N
authors.lastname: Hambly
authors.affiliation: 9 Departments of Medicine and Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.
authors.forename: Kerri A
authors.initials: KA
authors.lastname: Johannson
authors.affiliation: 13 Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Meena
authors.initials: M
authors.lastname: Kalluri
authors.affiliation: 1 Department of Medicine.
authors.forename: Nasreen
authors.initials: N
authors.lastname: Khalil
authors.affiliation: 8 Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Martin
authors.initials: M
authors.lastname: Kolb
authors.affiliation: 14 Department of Medicine, Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada; and.
authors.forename: Helene
authors.initials: H
authors.lastname: Manganas
authors.affiliation: 7 Division of Respiratory and Critical Care Medicine, Queen's University, Kingston, Ontario, Canada.
authors.forename: Onofre
authors.initials: O
authors.lastname: Morán-Mendoza
authors.affiliation: 6 Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Quebec City, Quebec, Canada.
authors.forename: Steve
authors.initials: S
authors.lastname: Provencher
authors.affiliation: 15 Royal Alexandra Hospital, Edmonton, Alberta, Canada.
authors.forename: Warren
authors.initials: W
authors.lastname: Ramesh
authors.affiliation: 1 Department of Medicine.
authors.forename: J Douglass
authors.initials: JD
authors.lastname: Rolf
authors.affiliation: 1 Department of Medicine.
authors.forename: Pearce G
authors.initials: PG
authors.lastname: Wilcox
authors.affiliation: 3 Department of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada.|2 Centre for Heart Lung Innovation, University of British Columbia and St. Paul's Hospital, Vancouver, British Columbia, Canada.
authors.forename: Jordan A
authors.initials: JA
authors.lastname: Guenette
mesh_terms: D000328:Adult; D000368:Aged; D002170:Canada; D004311:Double-Blind Method; D004417:Dyspnea / Q000628:therapy*; D005080:Exercise Test; D005081:Exercise Therapy / Q000379:methods; D017079:Exercise Tolerance; D005260:Female; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000503:physiopathology* / Q000628:therapy*; D007211:Indoles / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000627:therapeutic use*; D011788:Quality of Life; D012107:Research Design; D016896:Treatment Outcome; D014797:Vital Capacity; D055815:Young Adult
chemical_list: D007211:Indoles; C530716:nintedanib; D010100:Oxygen
keywords: interstitial lung disease; pulmonary rehabilitation; therapy