title: Synergistic Chemo-Photothermal Therapy of Breast Cancer by Mesenchymal Stem Cell-Encapsulated Yolk-Shell GNR@HPMO-PTX Nanospheres.
abstract: Mesenchymal stem cells (MSCs) have attracted increasing attention as vehicles for cancer treatment. Herein, MSC-based synergistic oncotherapy strategy is presented for the first time. To achieve this goal, yolk-shell structured gold nanorod embedded hollow periodic mesoporous organosilica nanospheres (GNR@HPMOs) with high paclitaxel (PTX) loading capability and excellent photothermal transfer ability upon near-infrared (NIR) light irradiation are first prepared. Cytotoxicity and migration assays show that the viability and tumor-homing capability of MSCs are well-retained after internalization of high content of PTX loaded GNR@HPMOs (denoted as GNR@HPMOs-PTX). In vitro experiments show the GNR@HPMOs-PTX loaded MSCs (GNR@HPMOs-PTX@MSCs) possess synergistic chemo-photothermal killing effects for breast cancer cells. Also, photoacoustic imaging shows that the MSCs can improve dispersion and distribution in tumor tissue for GNR@HPMOs-PTX after intratumoral injection. In vivo experiments in breast cancer model of nude mice further demonstrate that the GNR@HPMOs-PTX@MSCs significantly inhibit tumor growth, suggesting their great potential for synergistic therapy of cancer.
authors.forename: Jiang
authors.initials: J
authors.lastname: Wu
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Yuxia
authors.initials: Y
authors.lastname: Tang
authors.forename: Shouju
authors.initials: S
authors.lastname: Wang
authors.forename: Chunyan
authors.initials: C
authors.lastname: Wang
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Li
authors.affiliation: Key Laboratory for Organic Electronics & Information Displays and Institute of Advanced Materials, Nanjing University of Posts and Telecommunications , Nanjing 210046, P. R. China.
authors.forename: Xiaodan
authors.initials: X
authors.lastname: Su
authors.affiliation: Department of Radiotherapy, the Second Affiliated Hospital of Nanjing Medical University , Nanjing 210011, P. R. China.
authors.forename: Jihong
authors.initials: J
authors.lastname: Tian
authors.forename: Ying
authors.initials: Y
authors.lastname: Tian
authors.forename: Jing
authors.initials: J
authors.lastname: Pan
authors.forename: Yunyan
authors.initials: Y
authors.lastname: Su
authors.forename: Hong
authors.initials: H
authors.lastname: Zhu
authors.affiliation: State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing 210093, P. R. China.
authors.forename: Zhaogang
authors.initials: Z
authors.lastname: Teng
authors.affiliation: State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing 210093, P. R. China.
authors.forename: Guangming
authors.initials: G
authors.lastname: Lu
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000188:drug therapy / Q000628:therapy*; D016503:Drug Delivery Systems / Q000379:methods*; D005260:Female; D006046:Gold / Q000737:chemistry; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D061986:MCF-7 Cells; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000737:chemistry / Q000166:cytology / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D057145:Nanoshells / Q000008:administration & dosage / Q000737:chemistry; D054118:Nanospheres / Q000737:chemistry; D043942:Nanotubes / Q000737:chemistry; D017646:Organosilicon Compounds / Q000737:chemistry; D017239:Paclitaxel / Q000008:administration & dosage*; D010789:Phototherapy / Q000379:methods*; D011897:Random Allocation; D023041:Xenograft Model Antitumor Assays
chemical_list: D017646:Organosilicon Compounds; D006046:Gold; D017239:Paclitaxel
keywords: breast cancer; gold nanorods; mesenchymal stem cells; periodic mesoporous organosilica; synergistic therapy