title: Reactive oxygen species: sources, consequences and targeted therapy in type 2 diabetes.
abstract: Oxidative stress has been considered as a central mediator in the progression of diabetic complication. The intracellular reactive oxygen species (ROS) leads to oxidative stress and it is raised from the mitochondria as well as by activation of five major pathways: increased polyol pathway flux, activation of protein kinase C (PKC) pathway, increased formation of advanced glycation end products (AGEs), over activity of hexosamine pathway and increased production of angiotensin II. The increased ROS through these pathways leads to β-cell dysfunction and insulin resistance, responsible for cell damage and death. This review not only highlights the sources of ROS production and their involvement in the progression of diabetes, but also emphasizes on pharmacological interventions and targeting of ROS in type 2 diabetes. This review summarizes the ROS as potential therapeutic targets, based on a putative mechanism in the progression of the diabetes. It also summarizes current knowledge of ROS activation in type 2 diabetes as well as ROS as a possible target for its treatment. Eventually, it would be a promising target for various strategies and drugs to modulate ROS levels in diabetes.
authors.affiliation: a Department of Biotechnology , Guru Ghasidas Vishwavidyalaya (a Central University) , Bilaspur , India.
authors.forename: Suchitra Kumari
authors.initials: SK
authors.lastname: Panigrahy
authors.affiliation: a Department of Biotechnology , Guru Ghasidas Vishwavidyalaya (a Central University) , Bilaspur , India.
authors.forename: Renu
authors.initials: R
authors.lastname: Bhatt
authors.affiliation: b Department of Biotechnology , National Institute of Technology (NIT) , Raipur , India.
authors.forename: Awanish
authors.initials: A
authors.lastname: Kumar
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications / Q000628:therapy*; D006801:Humans; D007333:Insulin Resistance; D017382:Reactive Oxygen Species / Q000097:blood*
chemical_list: D017382:Reactive Oxygen Species
keywords: Diabetes; diagnosis; oxidative stress; reactive oxygen species; target