title: Novel Computed Tomography Scoring System for Sinus Disease in Adults With Cystic Fibrosis.
abstract: OBJECTIVE
  There is no easy to use scoring system for computed tomography (CT) scans of the sinuses that is specific to cystic fibrosis (CF). We propose a simple and easily implemented scoring system to quantify severity of sinus disease in adults with CF.
  
  
  METHODS
  Case series with chart review.
  
  
  METHODS
  Academic tertiary-care referral center.
  
  
  METHODS
  Sixty-nine adult patients with CF and 50 age-matched controls.
  
  
  METHODS
  We validated a scoring system for CF sinus disease. The CT scans were interpreted by 3 physicians on 2 separate sittings. Parameters include maxillary opacification, nasal obstruction, lateral nasal wall displacement, uncinate process absence/demineralization, and presence/absence of mucocele.
  
  
  RESULTS
  Patients with CF aged 21 to 30 years (mean = 24.7 ± 2.49). In CF cohort (n = 69), intrarater reliability for the 10 CT categories ranged from .70 to 1.00. Twenty-six (87%) were in the excellent range, and the remaining 4 (13%) were evaluated as good. In the non-CF cohort (n = 50), reliabilities ranged from .44 to 1.00. Twenty-seven (90%) were in the excellent range. For interrater reliability, in the CF cohort, 10 CT categories across the 3 raters ranged from .55 to 1.00. Excellent reliability was achieved in 15 (50%) of the observations. In the non-CF cohort, reliabilities ranged from .44 to 1.00.
  
  
  CONCLUSIONS
  A novel and easy to use CT scoring system for CF sinus disease in adults was validated with inter- and intrarater reliability. This new CF sinus disease-specific scoring system can be used by clinicians, surgeons, and radiologists.
authors.affiliation: Departments of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio, USA Section of Pulmonary Medicine, Nationwide Children's Hospital, Columbus, Ohio, USA Shahid.Sheikh@nationwidechildrens.org.
authors.forename: Shahid I
authors.initials: SI
authors.lastname: Sheikh
authors.affiliation: Radiology, The Ohio State University College of Medicine, Columbus, Ohio, USA Radiological Institute, Nationwide Children's Hospital, Columbus, Ohio, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Handly
authors.affiliation: Departments of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio, USA Section of Pulmonary Medicine, Nationwide Children's Hospital, Columbus, Ohio, USA.
authors.forename: Nancy A
authors.initials: NA
authors.lastname: Ryan-Wenger
authors.affiliation: Departments of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio, USA Section of Pulmonary Medicine, Nationwide Children's Hospital, Columbus, Ohio, USA Internal Medicine, The Ohio State University College of Medicine, Columbus, Ohio, USA.
authors.forename: Don
authors.initials: D
authors.lastname: Hayes
authors.affiliation: Departments of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio, USA Section of Pulmonary Medicine, Nationwide Children's Hospital, Columbus, Ohio, USA Internal Medicine, The Ohio State University College of Medicine, Columbus, Ohio, USA.
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Kirkby
authors.affiliation: Departments of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio, USA Section of Pulmonary Medicine, Nationwide Children's Hospital, Columbus, Ohio, USA.
authors.forename: Karen S
authors.initials: KS
authors.lastname: McCoy
authors.affiliation: Otolaryngology, The Ohio State University College of Medicine, Columbus, Ohio, USA Department of Otolaryngology, Nationwide Children's Hospital, Columbus, Ohio, USA.
authors.forename: Meredith
authors.initials: M
authors.lastname: Lind
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003550:Cystic Fibrosis / Q000150:complications / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D009078:Mucocele / Q000150:complications / Q000000981:diagnostic imaging*; D015508:Nasal Obstruction / Q000150:complications / Q000000981:diagnostic imaging*; D010256:Paranasal Sinuses / Q000000981:diagnostic imaging*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012720:Severity of Illness Index; D012852:Sinusitis / Q000150:complications / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed; D055815:Young Adult
keywords: CAT scan; adults; cystic fibrosis; scoring system; sinusitis