title: Thiotagetin A, a new cytotoxic thiophene from Tagetes minuta.
abstract: Phytochemical investigation of the n-hexane fraction of the methanolic extract of Tagetes minuta L. (Asteraceae) aerial parts afforded a new thiophene derivative: thiotagetin A (3), together with β-sitosterol (1) and stigmasterol (2). The structure of the new thiophene was identified by UV, IR, 1D (1H and13C), 2D (1H-1H COSY, HSQC and HMBC) NMR and HRESIMS spectral data. Compound 3 displayed cytotoxic activity against KB and MCF7 cancer cell lines with ED50values of 2.03 and 3.88 μg/mL, respectively, compared to adriamycin (0.26 and 0.07 μg/mL, respectively).
authors.affiliation: a Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy , Taibah University , Al Madinah Al Munawwarah , Saudi Arabia.|b Faculty of Pharmacy, Department of Pharmacognosy , Assiut University , Assiut , Egypt.
authors.forename: Sabrin R M
authors.initials: SR
authors.lastname: Ibrahim
authors.affiliation: c Faculty of Pharmacy, Department of Natural Products and Alternative Medicine , King Abdulaziz University , Jeddah , Saudi Arabia.|d Faculty of Pharmacy, Department of Pharmacognosy , Al-Azhar University, Assiut Branch , Assiut , Egypt.
authors.forename: Gamal A
authors.initials: GA
authors.lastname: Mohamed
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D045744:Cell Line, Tumor; D006801:Humans; D010936:Plant Extracts / Q000032:analysis; D031686:Tagetes / Q000737:chemistry*; D013876:Thiophenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D013876:Thiophenes
keywords: Tagetes minuta; cytotoxic activity; thiophene; thiotagetin A