title: Serial use of pentamidine and miltefosine for treating Leishmania infantum-HIV coinfection.
abstract: Liposomal amphotericin B (LAmb) may fail to heal Leishmania infantum visceral leishmaniasis (VL) in the immunodeficient host. There are currently no guidelines on how to treat such patients and efficacy of miltefosine monotherapy seems limited in this indication. We present 2 cases of patients with VL and AIDS for which LAmb had to be interrupted (one because of toxicity, one because of treatment failure) and who were treated effectively with pentamidine followed by miltefosine.
authors.affiliation: Service des maladies infectieuses et Tropicales, CHRU de Besançon, 25030 Besançon cedex, France. Electronic address: jffaucher@chu-besancon.fr.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Faucher
authors.affiliation: Service des maladies infectieuses et Tropicales, CHU de Montpellier, 34295 Montpellier cedex 5, France. Electronic address: d-morquin@chu-montpellier.fr.
authors.forename: David
authors.initials: D
authors.lastname: Morquin
authors.affiliation: Service des maladies infectieuses et Tropicales, CHU de Montpellier, 34295 Montpellier cedex 5, France. Electronic address: j-reynes@chu-montpellier.fr.
authors.forename: Jacques
authors.initials: J
authors.lastname: Reynes
authors.affiliation: Service des maladies infectieuses et Tropicales, CHRU de Besançon, 25030 Besançon cedex, France. Electronic address: cchirouze@chu-besancon.fr.
authors.forename: Catherine
authors.initials: C
authors.lastname: Chirouze
authors.affiliation: Service des maladies infectieuses et Tropicales, CHRU de Besançon, 25030 Besançon cedex, France. Electronic address: bruno.hoen@chu-guadeloupe.fr.
authors.forename: Bruno
authors.initials: B
authors.lastname: Hoen
authors.affiliation: Service des maladies infectieuses et Tropicales, CHU de Montpellier, 34295 Montpellier cedex 5, France. Electronic address: v-le_moing@chu-montpellier.fr.
authors.forename: Vincent
authors.initials: V
authors.lastname: Le Moing
mesh_terms: D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D060085:Coinfection / Q000188:drug therapy; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D016867:Immunocompromised Host; D018314:Leishmania infantum / Q000187:drug effects*; D007898:Leishmaniasis, Visceral / Q000188:drug therapy* / Q000469:parasitology; D010419:Pentamidine / Q000627:therapeutic use*; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000981:Antiprotozoal Agents; D010767:Phosphorylcholine; C039128:miltefosine; D010419:Pentamidine
keywords: Aids; Liposomal amphotericin B; Miltefosine; Pentamidine; Visceral leishmaniasis