title: Growth Outcomes of Preterm Infants Exposed to Different Oxygen Saturation Target Ranges from Birth.
abstract: To test whether infants randomized to a lower oxygen saturation (peripheral capillary oxygen saturation [SpO2]) target range while on supplemental oxygen from birth will have better growth velocity from birth to 36 weeks postmenstrual age (PMA) and less growth failure at 36 weeks PMA and 18-22 months corrected age.
  
  
  
  We evaluated a subgroup of 810 preterm infants from the Surfactant, Positive Pressure, and Oxygenation Randomized Trial, randomized at birth to lower (85%-89%, n = 402, PMA 26 ± 1 weeks, birth weight 839 ± 186 g) or higher (91%-95%, n = 408, PMA 26 ± 1 weeks, birth weight 840 ± 191 g) SpO2 target ranges. Anthropometric measures were obtained at birth, postnatal days 7, 14, 21, and 28; then at 32 and 36 weeks PMA; and 18-22 months corrected age. Growth velocities were estimated with the exponential method and analyzed with linear mixed models. Poor growth outcome, defined as weight <10th percentile at 36 weeks PMA and 18-22 months corrected age, was compared across the 2 treatment groups by the use of robust Poisson regression.
  
  
  
  Growth outcomes including growth at 36 weeks PMA and 18-22 months corrected age, as well as growth velocity were similar in the lower and higher SpO2 target groups.
  
  
  
  Targeting different oxygen saturation ranges between 85% and 95% from birth did not impact growth velocity or reduce growth failure in preterm infants.
authors.affiliation: University of Miami Miller School of Medicine, Miami, FL. Electronic address: cnavarrete@med.miami.edu.
authors.forename: Cristina T
authors.initials: CT
authors.lastname: Navarrete
authors.affiliation: Social, Statistical and Environmental Sciences Unit, RTI International, Research Triangle Park, NC.
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Wrage
authors.affiliation: Division of Neonatology, University of Alabama at Birmingham, Birmingham, AL.
authors.forename: Waldemar A
authors.initials: WA
authors.lastname: Carlo
authors.affiliation: Department of Pediatrics, Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, OH.
authors.forename: Michele C
authors.initials: MC
authors.lastname: Walsh
authors.affiliation: Division of Neonatology, University of California San Diego, San Diego, CA.
authors.forename: Wade
authors.initials: W
authors.lastname: Rich
authors.affiliation: Social, Statistical and Environmental Sciences Unit, RTI International, Research Triangle Park, NC.
authors.forename: Marie G
authors.initials: MG
authors.lastname: Gantz
authors.affiliation: Social, Statistical and Environmental Sciences Unit, RTI International, Rockville, MD.
authors.forename: Abhik
authors.initials: A
authors.lastname: Das
authors.affiliation: Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH.
authors.forename: Kurt
authors.initials: K
authors.lastname: Schibler
authors.affiliation: Division of Neonatology, University of California San Diego, San Diego, CA.
authors.forename: Nancy S
authors.initials: NS
authors.lastname: Newman
authors.affiliation: Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, Atlanta, GA.
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Piazza
authors.affiliation: Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN.
authors.forename: Brenda B
authors.initials: BB
authors.lastname: Poindexter
authors.affiliation: Department of Pediatrics, Wayne State University, Detroit, MI.
authors.forename: Seetha
authors.initials: S
authors.lastname: Shankaran
authors.affiliation: Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX.
authors.forename: Pablo J
authors.initials: PJ
authors.lastname: Sánchez
authors.affiliation: Department of Pediatrics, University of Texas Medical School at Houston, Houston, TX.
authors.forename: Brenda H
authors.initials: BH
authors.lastname: Morris
authors.affiliation: Division of Newborn Medicine, Department of Pediatrics, Floating Hospital for Children, Tufts Medical Center, Boston, MA.
authors.forename: Ivan D
authors.initials: ID
authors.lastname: Frantz
authors.affiliation: Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, CA.
authors.forename: Krisa P
authors.initials: KP
authors.lastname: Van Meurs
authors.affiliation: Department of Pediatrics, Duke University, Durham, NC.
authors.forename: C Michael
authors.initials: CM
authors.lastname: Cotten
authors.affiliation: Department of Pediatrics, Yale University School of Medicine, New Haven, CT.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Ehrenkranz
authors.affiliation: Department of Pediatrics, University of Iowa, Iowa City, IA.
authors.forename: Edward F
authors.initials: EF
authors.lastname: Bell
authors.affiliation: University of New Mexico Health Sciences Center, Albuquerque, NM.
authors.forename: Kristi L
authors.initials: KL
authors.lastname: Watterberg
authors.affiliation: Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD.
authors.forename: Rosemary D
authors.initials: RD
authors.lastname: Higgins
authors.affiliation: University of Miami Miller School of Medicine, Miami, FL.
authors.forename: Shahnaz
authors.initials: S
authors.lastname: Duara
mesh_terms: D005260:Female; D006128:Growth; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D010092:Oximetry; D010100:Oxygen / Q000008:administration & dosage / Q000378:metabolism*; D012121:Respiration, Artificial
chemical_list: D010100:Oxygen
keywords: ELBW growth; oxygen saturation target