title: Geometry matters: inverse cytotoxic relationship for cis/trans-Ru(ii) polypyridyl complexes from cis/trans-[PtCl2(NH3)2].
abstract: Two thermally activated ruthenium(ii) polypyridyl complexes, cis-Ru(bpy)2Cl2 and trans-Ru(qpy)Cl2 were investigated to determine the impact of the geometric arrangement of the exchangable ligands on the potential of the compounds to act as chemotherapeutics. In contrast to the geometry requirements for cisplatin, trans-Ru(qpy)Cl2 was 7.1-9.5× more cytotoxic than cis-Ru(bpy)2Cl2. This discovery could open up a new area of metal-based chemotherapeutic research.
authors.affiliation: Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA. ec.glazer@uky.edu.
authors.forename: Erin
authors.initials: E
authors.lastname: Wachter
authors.affiliation: Departamento de Química Inorgánica and Regional Campus of International Excellence "Campus Mare Nostrum", Universidad de Murcia, and Institute for Bio-Health Research of Murcia (IMIB-Arrixaca), E-30771 Murcia, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Zamora
authors.affiliation: Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA. ec.glazer@uky.edu.
authors.forename: David K
authors.initials: DK
authors.lastname: Heidary
authors.affiliation: Departamento de Química Inorgánica and Regional Campus of International Excellence "Campus Mare Nostrum", Universidad de Murcia, and Institute for Bio-Health Research of Murcia (IMIB-Arrixaca), E-30771 Murcia, Spain.
authors.forename: José
authors.initials: J
authors.lastname: Ruiz
authors.affiliation: Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA. ec.glazer@uky.edu.
authors.forename: Edith C
authors.initials: EC
authors.lastname: Glazer