title: The effect of 1 mg folic acid supplementation on clinical outcomes in female migraine with aura patients.
abstract: BACKGROUND
  Migraine is a common neurovascular condition that may be linked to hyperhomocysteinemia. We have previously provided evidence that reduction of homocysteine with a vitamin supplementation can reduce the occurrence of migraine in women. The current study examined the occurrence of migraine in response to vitamin supplementation with a lower dose of folic acid.
  
  
  METHODS
  This was a 6 month randomised, double blinded placebo controlled trial of daily vitamin supplementation containing 1 mg of folic acid, 25 mg of Vitamin B6 and Vitamin B12, on reduction of homocysteine and the occurrence of migraine in 300 female patients diagnosed with migraine with aura.
  
  
  RESULTS
  Vitamin supplementation with 1 mg of folic acid, did not significantly decrease homocysteine levels (P = 0.2). The treatment group did not show a significant decrease in the percentage of participants with high migraine disability, severity or frequency at the end of the 6 month intervention (P > 0.1).
  
  
  CONCLUSIONS
  1 mg of folic acid in combination with vitamin B6 and B12 is less effective in reducing migraine associated symptoms compared to the previously tested dosage of 2 mg folic acid in combination with 25 mg of vitamin B6 and 400 μg of vitamin B12.
authors.affiliation: Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia.
authors.forename: Saras
authors.initials: S
authors.lastname: Menon
authors.affiliation: Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia.
authors.forename: Bushra
authors.initials: B
authors.lastname: Nasir
authors.affiliation: Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia.
authors.forename: Nesli
authors.initials: N
authors.lastname: Avgan
authors.affiliation: Centre for Integrated Preclinical Drug Development Faculty of Medicine and Biomedical Sciences, University of Queensland, Brisbane, QLD, Australia.
authors.forename: Sussan
authors.initials: S
authors.lastname: Ghassabian
authors.affiliation: Blackmores Institute, 20 Jubilee Avenue, Warriewood, NSW 2102, Australia.
authors.forename: Christopher
authors.initials: C
authors.lastname: Oliver
authors.affiliation: Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia.
authors.forename: Rodney
authors.initials: R
authors.lastname: Lea
authors.affiliation: Centre for Integrated Preclinical Drug Development Faculty of Medicine and Biomedical Sciences, University of Queensland, Brisbane, QLD, Australia.
authors.forename: Maree
authors.initials: M
authors.lastname: Smith
authors.affiliation: Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia. lyn.griffiths@qut.edu.au.
authors.forename: Lyn
authors.identifier: http://orcid.org/0000-0002-6774-5475
authors.initials: L
authors.lastname: Griffiths
mesh_terms: D000293:Adolescent; D000328:Adult; D019587:Dietary Supplements; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D020325:Migraine with Aura / Q000175:diagnosis* / Q000188:drug therapy*; D016896:Treatment Outcome; D014805:Vitamin B 12 / Q000008:administration & dosage*; D025101:Vitamin B 6 / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D025101:Vitamin B 6; D005492:Folic Acid; D014805:Vitamin B 12
keywords: Folate; Folic acid; Migraine; Vitamin B12; Vitamin B6