title: Focal intestinal lipogranulomatous lymphangitis in 10 dogs.
abstract: OBJECTIVE
  To describe the clinical and pathological features of canine focal lipogranulomatous lymphangitis, to evaluate its underlying infectious cause and to compare it with human Crohn's disease.
  
  
  METHODS
  Retrospective review of case records with a histopathological diagnosis of focal lipogranulomatous lymphangitis. Bacterial and fungal colonisation was evaluated using fluorescence in situ hybridisation and histochemical staining, respectively. A comparison with Crohn's disease was performed by a human pathologist.
  
  
  RESULTS
  Ten dogs were evaluated. The historical complaints were predominantly chronic diarrhoea (10/10) and vomiting (5/10). The biochemical abnormalities included hypoalbuminaemia (6/10) and hypocobalaminaemia (4/6). Abdominal sonography revealed a thickened distal ileum±ileocolic junction. Colonoscopy showed a swollen caecal ostium and oedematous caecum in 7/10 dogs. A stenotic ileo-colic opening prevented endoscopic intubation in all dogs. Histology from the resected lesions revealed granulomatous inflammation involving the muscularis and serosa. Fluorescence in situ hybridization demonstrated invasive bacteria in 2/10 dogs. Post-resection, all dogs received metronidazole and tapering immunosuppressive doses of prednisolone. Remission (median 17 months) was achieved in 8/10 dogs.
  
  
  CONCLUSIONS
  Focal lipogranulomatous lymphangitis is a rare and severe form of canine inflammatory bowel disease with preferential localisation to the ileum and the ileocolic junction. An underlying infectious aetiology was not identified.
authors.affiliation: Service de Médecine Interne, VetAgro Sup Campus Vétérinaire, Université de Lyon, 69280 Marcy l'Etoile, 69007 Lyon, France.
authors.forename: A
authors.initials: A
authors.lastname: Lecoindre
authors.affiliation: CVC Clinique des Cerisioz, Route de Saint-Symphorien-d'Ozon, 69800 Lyon, France.
authors.forename: P
authors.initials: P
authors.lastname: Lecoindre
authors.affiliation: Service de Médecine interne, VetAgro Sup Campus Vétérinaire, Université de Lyon, 69280 Marcy l'Etoile, 69007 Lyon, France.
authors.forename: J L
authors.initials: JL
authors.lastname: Cadoré
authors.affiliation: Laboratoire Biomnis, 17/19 avenue Tony Garnier, 69007, Lyon, France.
authors.forename: M
authors.initials: M
authors.lastname: Chevallier
authors.affiliation: Laboratoire Biomnis, 17/19 avenue Tony Garnier, 69007, Lyon, France.
authors.forename: S
authors.initials: S
authors.lastname: Guerret
authors.affiliation: Clinique Vétérinaire de la Plage, 1 Promenade George Pompidou, 13008, Marseille, France.
authors.forename: G
authors.initials: G
authors.lastname: Derré
authors.affiliation: Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, 14853, USA.
authors.forename: S P
authors.initials: SP
authors.lastname: Mcdonough
authors.affiliation: College of Veterinary Medicine, Cornell University, Ithaca, New York, 14853, USA.
authors.forename: K W
authors.initials: KW
authors.lastname: Simpson
mesh_terms: D000818:Animals; D003424:Crohn Disease / Q000473:pathology; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D006099:Granuloma / Q000473:pathology / Q000662:veterinary*; D017404:In Situ Hybridization, Fluorescence / Q000662:veterinary; D008205:Lymphangitis / Q000473:pathology / Q000662:veterinary*; D008297:Male; D008499:Medical Records; D011504:Protein-Losing Enteropathies / Q000473:pathology / Q000662:veterinary*; D012189:Retrospective Studies