title: Polymer Capsules for Plaque-Targeted In Vivo Delivery.
abstract: Targeted polymer capsules can selectively bind to unstable plaques in mice after intravenous injection. Different formulations of the capsules are explored with a synthetic/biopolymer hybrid capsule showing the best stability and small-molecule drug retention. The synthetic polymer is composed of pH-sensitive blocks (PDPA), low-binding blocks (PEG), and click-groups for postfunctionalization with targeting peptides specific to plaques.
authors.affiliation: ARC Centre of Excellence in Convergent Bio-Nano Science and Technology and the Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria, 3010, Australia.
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Richardson
authors.affiliation: NanoBiotechnology Laboratory, Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, 3004, Australia.
authors.forename: Mei Y
authors.initials: MY
authors.lastname: Choy
authors.affiliation: ARC Centre of Excellence in Convergent Bio-Nano Science and Technology and the Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria, 3010, Australia.
authors.forename: Junling
authors.initials: J
authors.lastname: Guo
authors.affiliation: ARC Centre of Excellence in Convergent Bio-Nano Science and Technology and the Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria, 3010, Australia.
authors.forename: Kang
authors.initials: K
authors.lastname: Liang
authors.affiliation: NanoBiotechnology Laboratory, Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, 3004, Australia.
authors.forename: Karen
authors.initials: K
authors.lastname: Alt
authors.affiliation: ARC Centre of Excellence in Convergent Bio-Nano Science and Technology and the Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria, 3010, Australia.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Ping
authors.affiliation: ARC Centre of Excellence in Convergent Bio-Nano Science and Technology and the Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria, 3010, Australia.
authors.forename: Jiwei
authors.initials: J
authors.lastname: Cui
authors.affiliation: NanoBiotechnology Laboratory, Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, 3004, Australia.
authors.forename: Lok S
authors.initials: LS
authors.lastname: Law
authors.affiliation: NanoBiotechnology Laboratory, Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, 3004, Australia. christoph.hagemeyer@monash.edu.
authors.forename: Christoph E
authors.initials: CE
authors.lastname: Hagemeyer
authors.affiliation: ARC Centre of Excellence in Convergent Bio-Nano Science and Technology and the Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria, 3010, Australia. fcaruso@unimelb.edu.au.
authors.forename: Frank
authors.initials: F
authors.lastname: Caruso
mesh_terms: D000818:Animals; D002214:Capsules / Q000008:administration & dosage* / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D051379:Mice; D058225:Plaque, Amyloid / Q000188:drug therapy*; D011108:Polymers / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D002214:Capsules; D011108:Polymers
keywords: click-chemistry; degradation; nanomedicine; polymer blends; templating