title: [Efficacy of lisdexamphetamine to improve the behavioural and cognitive symptoms of attention deficit hyperactivity disorder: treatment monitored by means of the AULA Nesplora virtual reality test].
abstract: BACKGROUND
  Lisdexanfetamine (LDX) is the drug for attention deficit hyperactivity disorder (ADHD) undergoing the largest research volume in the latest years. However, no studies certify its usefulness for the improvement of cognitive functioning in ADHD.
  
  
  OBJECTIVE
  To evaluate the efficacy of LDX in the behavioral and cognitive improvement of a group of patients with ADHD. Such efficacy was measured by means of the administration of AULA Nesplora virtual reality test before the prescription of pharmacological treatment and right after the treatment with LDX.
  
  
  METHODS
  The sample comprised 85 patients between 6 and 16 years, with clinical diagnosis of ADHD, who attended treatment in a neuropediatrics consultation. All patients started pharmacological treatment with the proper dose of LDX after the clinical interview and the first administration of AULA test. After an average treatment of 7.5 months, AULA was administered again and the treatment progress based on cognitive and motor symptomatology was assessed.
  
  
  RESULTS
  Results showed highly significant improvements in selective and sustained attention, quality of attention focus and hyperactivity; moderate improvements in impulsivity; and an incidence close to zero in processing speed.
  
  
  CONCLUSIONS
  LDX constitutes an adequate treatment for the substantial improvement of attention and hyperactivity; such improvement can be monitored accurately by means of AULA virtual reality test.
authors.affiliation: Nesplora, Technology , Donostia-San Sebastian, Espana.
authors.forename: U
authors.initials: U
authors.lastname: Diaz-Orueta
authors.affiliation: INANP Instituto Andaluz de Neurologia Pediatrica, Sevilla, Espana.
authors.forename: M A
authors.initials: MA
authors.lastname: Fernandez-Fernandez
authors.affiliation: INANP Instituto Andaluz de Neurologia Pediatrica, Sevilla, Espana.
authors.forename: M D
authors.initials: MD
authors.lastname: Morillo-Rojas
authors.affiliation: Nesplora, Technology , Donostia-San Sebastian, Espana.
authors.forename: G
authors.initials: G
authors.lastname: Climent
mesh_terms: D000293:Adolescent; D001288:Attention; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy*; D000697:Central Nervous System Stimulants; D002648:Child; D003071:Cognition; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000188:drug therapy; D006801:Humans; D000069478:Lisdexamfetamine Dimesylate / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000697:Central Nervous System Stimulants; D000069478:Lisdexamfetamine Dimesylate