title: [Procedure guidelines for radioiodine therapy of differentiated thyroid cancer. Version 4].
abstract: The procedure guideline for radioiodine therapy of differentiated thyroid cancer (version 4) was developed in the consensus of a representative expert group. This fulfils the level S1 (first step) within the AWMF classification of Clinical Practice Guidelines (AWMF, Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften, Germany). This procedure guideline completed the guideline for surgical management of thyroid cancer (level S2) with the aspects from nuclear medicine. Controversies over ablative radioiodine therapy in small papillary thyroid cancers and in minimally invasive follicular cancer without angioinvasion, over empirical standard doses for ablative radioiodine therapy, and over the kind of TSH-stimulation were described and the guideline formulated a corridor of good clinical practice. The text has included the recent results from the National Cancer database and the SEER database (both from the USA), indicating that the ablative radioiodine therapy has improved the survival rate even in low risk patients. Such a statistically significant benefit can be detected only by a national cancer registry with long-term follow-up data.
authors.affiliation: Prof. Dr. med. Markus Dietlein, Klinik und Poliklinik für Nuklearmedizin, Universitätsklinikum Köln, Kerpener Str. 62, 50937 Köln, Tel. 02 21/478 50 24, Fax 02 21/47 88 90 85, markus.dietlein@uni-koeln.de.
authors.forename: Markus
authors.initials: M
authors.lastname: Dietlein
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Eschner
authors.forename: Frank
authors.initials: F
authors.lastname: Grünwald
authors.forename: Michael
authors.initials: M
authors.lastname: Lassmann
authors.forename: Frederik A
authors.initials: FA
authors.lastname: Verburg
authors.forename: Markus
authors.initials: M
authors.lastname: Luster
mesh_terms: D019317:Evidence-Based Medicine; D005858:Germany; D006801:Humans; D007457:Iodine Radioisotopes / Q000592:standards / Q000627:therapeutic use*; D008495:Medical Oncology / Q000592:standards*; D009683:Nuclear Medicine / Q000592:standards*; D017410:Practice Guidelines as Topic; D019275:Radiopharmaceuticals / Q000592:standards / Q000627:therapeutic use; D011878:Radiotherapy / Q000592:standards*; D013964:Thyroid Neoplasms / Q000532:radiotherapy*; D016896:Treatment Outcome
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals
keywords: Guideline; differentiated thyroid cancer; dosimetry; radioiodine ablation; radioiodine therapy; recombinant human thyrotropin