title: [Association between β-arrestin2 genetic polymorphism and response to methadone maintenance treatment in heroin-dependent patients in Han population in Hunan province].
abstract: OBJECTIVE
  To study the distributions of three single nucleotide polymorphisms (SNPs) in β-arrestin2 (ARRB2) which including rs3786047, rs1045280 and rs2036657 and to elucidate the relationship between these SNPs and response to methadone maintenance treatment (MMT) among heroin-dependent patients of Han ethnicity population in Hunan.
  
  
  METHODS
  Han MMT patients were recruited in four random-chosen MMT clinics from Hunan province. Demographics, history of drug-use and MMT were recorded. ARRB2 SNPs were genotyped to determine the association between SNPs and response to MMT.
  
  
  RESULTS
  Distributions of the three SNPs were in Hardy-Weinberg equilibrium in both groups (responders vs. non-responders). There was no statistical significance in the distribution frequency of genotype on rs3786047 (χ(2)=0.486 2, P=0.784), rs1045280 (χ(2)=1.591 9, P=0.451) and rs2036657 (χ(2)=1.061 5, P=0.588) in ARRB2 among the responders or the non-responders.
  
  
  CONCLUSIONS
  Associations between the ARRB2 genotypes, rs3786047, rs1045280 and rs2036657, and MMT response in Han MMT patients in Hunan province did not appear.
authors.affiliation: Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha 410078, China.
authors.forename: R
authors.initials: R
authors.lastname: Luo
authors.affiliation: Central Laboratory, Xiangya School of Public Health, Central South University, Changsha 410078, China.
authors.forename: X L
authors.initials: XL
authors.lastname: Feng
authors.affiliation: Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha 410078, China.
authors.forename: X
authors.initials: X
authors.lastname: Luo
authors.affiliation: Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha 410078, China.
authors.forename: Z S
authors.initials: ZS
authors.lastname: Liu
authors.affiliation: Department of Scientific Research, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: P W
authors.initials: PW
authors.lastname: Hu
authors.affiliation: Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha 410078, China.
authors.forename: S
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha 410078, China.
authors.forename: X L
authors.initials: XL
authors.lastname: Li
mesh_terms: D002681:China; D005838:Genotype; D003932:Heroin; D006801:Humans; D058850:Opiate Substitution Treatment; D020641:Polymorphism, Single Nucleotide; D000071560:beta-Arrestin 2
chemical_list: D000071560:beta-Arrestin 2; D003932:Heroin