title: Association study of Glutathione S-Transferase polymorphisms and risk of endometriosis in an Iranian population.
abstract: BACKGROUND
  Endometriosis influenced by both genetic and environmental factors. Associations of glutathione S-transferases (GSTs) genes polymorphisms in endometriosis have been investigated by various researchers; however, the results are not consistent.
  
  
  OBJECTIVE
  We examined the associations of GSTM1 and GSTT1 null genotypes and GSTP1 313 A/G polymorphisms with endometriosis in an Iranian population.
  
  
  METHODS
  In this case-control study, 151 women with diagnosis of endometriosis and 156 normal healthy women as control group were included. The genotyping was determined using multiplex PCR and PCR- RFLP methods.
  
  
  RESULTS
  The GSTM1 null genotype was significantly higher (p=0.027) in the cases (7.3%) than the control group (1.3%). There was no significant difference between the frequency of GSTT1 genotypes between the cases and controls. The GSTP1 313 AG genotype was significantly lower (p=0.048) in the case (33.1%) than the control group (44.4%).
  
  
  CONCLUSIONS
  Our results showed that GSTM1 and GSTP1 polymorphisms may be associated with susceptibility of endometriosis in Iranian women.
authors.affiliation: Department of Biology, Faculty of Science, University of Kurdistan, Sanandaj, Iran.
authors.forename: Mina
authors.initials: M
authors.lastname: Hassani
authors.affiliation: Reproductive Biotechnology Research Center, Avicenna Research Institute (ACECR), Tehran, Iran.
authors.forename: Kioomars
authors.initials: K
authors.lastname: Saliminejad
authors.affiliation: Department of Biology, Faculty of Science, University of Kurdistan, Sanandaj, Iran.
authors.forename: Masood
authors.initials: M
authors.lastname: Heidarizadeh
authors.affiliation: Reproductive Biotechnology Research Center, Avicenna Research Institute (ACECR), Tehran, Iran.
authors.forename: Koorosh
authors.initials: K
authors.lastname: Kamali
authors.affiliation: Central Research Lab, North Khorasan University of Medical Sciences, Bojnurd, Iran.
authors.forename: Toktam
authors.initials: T
authors.lastname: Memariani
authors.affiliation: Genetic Research Center, University of Social Welfare and Rehabilitation Science, Tehran, Iran.; Avicenna Research Institute, Shahid Beheshti University, Tehran, Iran.
authors.forename: Hamid Reza
authors.initials: HR
authors.lastname: Khorram Khorshid
keywords: Association study; Endometriosis; GSTM1; GSTP1; GSTT1; Polymorphism