title: Primary stability and osseointegration of dental implants in polylactide modified bone - A pilot study in Goettingen minipigs.
abstract: The present study aimed to evaluate primary stability (PS) and osseointegration of dental implants in polylactide [70/30 poly(l-lactide-co-d, l-lactide); (PLDLA)] modified bone in 30 Goettingen minipigs. Each animal received three implants per jaw quadrant. In a split-mouth design, one side of the maxilla and mandible was randomly allocated to the experimental treatment (PLDLA applied into the drill hole before implantation), while the contralateral sides served as intraindividual controls (no PLDLA applied). The required insertion torque and the implant stability quotient (ISQ) were measured during implantation. ISQ, volume density (VD) of new bone formation (NBF), and the bone-implant contact (BIC) were evaluated at the end of the observation period (1, 3, 6, 12, and 24 months, respectively) in six animals each. Across all study groups, the PLDLA treatment resulted in a) a comparable insertion torque, b) an equivalent ISQ, c) a reduced BIC, and d) a reduced VD of NBF, as opposed to the untreated controls. In conclusion, the PLDLA treatment did not affect the PS, but rather led to an impaired osseointegration, which was particularly strong in the compact mandibular bone, and decreased in the spongious maxillary bone. PLDLA induced anchoring in spongious bone should be evaluated in further investigations.
authors.affiliation: Department of Oral and Maxillofacial Surgery, University of Goettingen, Robert-Koch-Str. 40, D-37075 Goettingen, Germany. Electronic address: ph.brockmeyer@gmail.com.
authors.forename: Phillipp
authors.initials: P
authors.lastname: Brockmeyer
authors.affiliation: Department of Prosthodontics, University of Goettingen, Robert-Koch-Str. 40, D-37075 Goettingen, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Krohn
authors.affiliation: Department of Oral and Maxillofacial Surgery, University of Goettingen, Robert-Koch-Str. 40, D-37075 Goettingen, Germany.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Thiemann
authors.affiliation: Department of Medical Statistics, University of Goettingen, Humboldtallee 32, D-37073 Goettingen, Germany.
authors.forename: Xenia
authors.initials: X
authors.lastname: Schulz
authors.affiliation: Department of Oral and Maxillofacial Surgery, University of Goettingen, Robert-Koch-Str. 40, D-37075 Goettingen, Germany.
authors.forename: Philipp
authors.initials: P
authors.lastname: Kauffmann
authors.affiliation: Department of Oral and Maxillofacial Surgery, University of Goettingen, Robert-Koch-Str. 40, D-37075 Goettingen, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Tröltzsch
authors.affiliation: School of Life Sciences FHNW, Gruendenstrasse 40, CHE-4132 Muttenz, Switzerland.
authors.forename: Falko
authors.initials: F
authors.lastname: Schlottig
authors.affiliation: Department of Oral and Maxillofacial Surgery, University of Goettingen, Robert-Koch-Str. 40, D-37075 Goettingen, Germany.
authors.forename: Henning
authors.initials: H
authors.lastname: Schliephake
authors.affiliation: Department of Oral and Maxillofacial Surgery, University of Goettingen, Robert-Koch-Str. 40, D-37075 Goettingen, Germany.
authors.forename: Rudolf Matthias
authors.initials: RM
authors.lastname: Gruber
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001842:Bone and Bones / Q000737:chemistry / Q000000981:diagnostic imaging / Q000187:drug effects*; D003757:Dental Implantation; D015921:Dental Implants; D017267:Dental Prosthesis Design; D023421:Models, Animal; D016348:Osseointegration; D010865:Pilot Projects; D011091:Polyesters / Q000494:pharmacology*; D011897:Random Allocation; D013552:Swine; D013556:Swine, Miniature
chemical_list: D015921:Dental Implants; D011091:Polyesters; C033616:poly(lactide)
keywords: 70/30 poly(l-lactide-co-d, l-lactide); Dental implants; Osseointegration; Polylactide modified bone; Primary stability