title: Effects of electromagnetic field exposure on conduction and concentration of voltage gated calcium channels: A Brownian dynamics study.
abstract: A three-dimensional Brownian Dynamics (BD) in combination with electrostatic calculations is employed to specifically study the effects of radiation of high frequency electromagnetic fields on the conduction and concentration profile of calcium ions inside the voltage-gated calcium channels. The electrostatic calculations are performed using COMSOL Multiphysics by considering dielectric interfaces effectively. The simulations are performed for different frequencies and intensities. The simulation results show the variations of conductance, average number of ions and the concentration profiles of ions inside the channels in response to high frequency radiation. The ionic current inside the channel increases in response to high frequency electromagnetic field radiation, and the concentration profiles show that the residency of ions in the channel decreases accordingly.
authors.affiliation: Computational Nano-Bioelectromagnetics Research Group, School of Nano-Science, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran.
authors.forename: Tahereh
authors.initials: T
authors.lastname: Tekieh
authors.affiliation: Department of Medical Physics & Biomedical Engineering, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Computational Nano-Bioelectromagnetics Research Group, School of Nano-Science, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran. Electronic address: pesasanpour@sbmu.ac.ir.
authors.forename: Pezhman
authors.initials: P
authors.lastname: Sasanpour
authors.affiliation: Department of Medical Physics & Biomedical Engineering, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: rafii-tabar@nano.ipm.ac.ir.
authors.forename: Hashem
authors.initials: H
authors.lastname: Rafii-Tabar
mesh_terms: D055592:Biophysical Phenomena; D002118:Calcium / Q000378:metabolism* / Q000528:radiation effects*; D015220:Calcium Channels / Q000378:metabolism* / Q000528:radiation effects*; D020013:Calcium Signaling / Q000528:radiation effects*; D004574:Electromagnetic Fields; D008962:Models, Theoretical; D056004:Molecular Dynamics Simulation
chemical_list: D015220:Calcium Channels; D002118:Calcium
keywords: Brownian Dynamics; COMSOL Multiphysics; Electromagnetic radiation; Voltage gated calcium channel