title: Pulmonary embolism and mortality following total ankle replacement: a data linkage study using the NJR data set.
abstract: To determine the mortality rate following total ankle replacement (TAR) and incidence of 90 day pulmonary embolism (PE) along with the associated risk factors.
  
  
  
  Data-linkage study of the UK National Joint Registry (NJR) data and Hospital Episodes Statistics (HES) database. Linkage was performed in a deterministic fashion. HES episodes 90 days after the index procedure were analysed for PE. Mortality data were obtained pertaining to all the index procedures from the NJR for analysis.
  
  
  
  All primary and revision ankle replacement patients captured on the NJR between February 2008 and February 2013.
  
  
  
  The 90-day mortality following TAR was 0.13% (95% CI 0.03 to 0.52) and 1-year mortality was 0.72% (95% CI 0.40 to 1.30); no deaths were as a result of PE. The incidence of PE within 90 days following primary TAR was 0.51% (95% CI 0.23 to 1.13). There was only one PE following revision surgery. Patients with an Royal College of Surgeons Charlson score greater than zero were at 13 times greater risk of PE (p=0.003).
  
  
  
  There is low incidence of PE following TAR, but multiple comorbidities are a leading risk factor for its occurrence.
authors.affiliation: Institute of Orthopaedics & Musculoskeletal Science, Royal National Orthopaedic Hospital NHS Trust, London, UK.
authors.forename: Razi
authors.initials: R
authors.lastname: Zaidi
authors.affiliation: Norwich Medical School, University of East Anglia, Norwich, UK.
authors.forename: Alexander
authors.initials: A
authors.lastname: MacGregor
authors.affiliation: Clinical Trials Unit at UCL, Medical Research Council (MRC), London, UK.
authors.forename: Suzie
authors.initials: S
authors.lastname: Cro
authors.affiliation: Institute of Orthopaedics & Musculoskeletal Science, Royal National Orthopaedic Hospital NHS Trust, London, UK.
authors.forename: Andy
authors.initials: A
authors.lastname: Goldberg
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D064386:Ankle Fractures / Q000150:complications / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D058737:Arthroplasty, Replacement, Ankle / Q000009:adverse effects* / Q000401:mortality; D015897:Comorbidity; D016208:Databases, Factual; D005260:Female; D006801:Humans; D007103:Immobilization / Q000009:adverse effects*; D015994:Incidence; D016247:Information Storage and Retrieval; D008297:Male; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000209:etiology* / Q000401:mortality / Q000503:physiopathology; D012042:Registries / Q000706:statistics & numerical data*; D012086:Reoperation / Q000706:statistics & numerical data; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013222:State Medicine
keywords: ankle replacement; data linkage; registry