title: Sensory Processing in Rhesus Monkeys: Developmental Continuity, Prenatal Treatment, and Genetic Influences.
abstract: Neonatal sensory processing (tactile and vestibular function) was tested in 78 rhesus macaques from two experiments. At ages 4-5 years, striatal dopamine D2receptor binding was examined using positron emission tomography. At ages 5-7 years, adult sensory processing was assessed. Findings were: (a) prenatal stress exposure yielded less optimal neonatal sensory processing; (b) animals carrying the short rh5-HTTLPR allele had less optimal neonatal sensory scores than monkeys homozygous for the long allele; (c) neonatal sensory processing was significantly related to striatal D2receptor binding for carriers of the short allele, but not for animals homozygous for the long allele; and (d) there was moderate developmental continuity in sensory processing from the neonatal period to adulthood.
authors.affiliation: Department of Kinesiology, University of Wisconsin-Madison.|Harlow Center for Biological Psychology, University of Wisconsin-Madison.|Department of Psychology, University of Wisconsin-Madison.
authors.forename: Mary L
authors.initials: ML
authors.lastname: Schneider
authors.affiliation: Department of Psychology, University of Wisconsin-Madison.|Department of Psychology, Montana State University-Bozeman.
authors.forename: Colleen F
authors.initials: CF
authors.lastname: Moore
authors.affiliation: Department of Kinesiology, University of Wisconsin-Madison.
authors.forename: Miriam
authors.initials: M
authors.lastname: Adkins
authors.affiliation: National Institutes of Health.
authors.forename: Christina S
authors.initials: CS
authors.lastname: Barr
authors.affiliation: Department of Kinesiology, University of Wisconsin-Madison.|Harlow Center for Biological Psychology, University of Wisconsin-Madison.
authors.forename: Julie A
authors.initials: JA
authors.lastname: Larson
authors.affiliation: Department of Kinesiology, University of Wisconsin-Madison.|Harlow Center for Biological Psychology, University of Wisconsin-Madison.
authors.forename: Leslie M
authors.initials: LM
authors.lastname: Resch
authors.affiliation: Minnesota State University-Mankato.
authors.forename: Andrew
authors.initials: A
authors.lastname: Roberts
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000502:physiology*; D002492:Central Nervous System Depressants / Q000008:administration & dosage / Q000009:adverse effects*; D000431:Ethanol / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D008253:Macaca mulatta / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D049268:Positron-Emission Tomography; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology*; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D013315:Stress, Psychological / Q000150:complications*; D055698:Touch Perception / Q000502:physiology*
chemical_list: D002492:Central Nervous System Depressants; D017448:Receptors, Dopamine D2; D050486:Serotonin Plasma Membrane Transport Proteins; D000431:Ethanol