title: m(6)A: Signaling for mRNA splicing.
abstract: Among myriads of distinct chemical modifications in RNAs, dynamic N6-methyladenosine (m(6)A) is one of the most prevalent modifications in eukaryotic mRNAs and non-coding RNAs. Similar to the critical role of chemical modifications in regulation of DNA and protein activities, RNA m(6)A modification is also observed to be involved in the regulation of diverse functions of RNAs including meiosis, fertility, development, cell reprogramming and circadian period. The RNA m(6)A modification is recognized by YTH domain containing family proteins comprising of YTHDC1-2 and YTHDF1-3. Here we focus on the nuclear m(6)A reader YTHDC1 and its regulatory role in alternative splicing and other RNA metabolic processes.
authors.affiliation: a Key Laboratory of Genomic and Precision Medicine , Collaborative Innovation Center of Genetics and Development, CAS Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing , China.
authors.forename: Samir
authors.initials: S
authors.lastname: Adhikari
authors.affiliation: a Key Laboratory of Genomic and Precision Medicine , Collaborative Innovation Center of Genetics and Development, CAS Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing , China.
authors.forename: Wen
authors.initials: W
authors.lastname: Xiao
authors.affiliation: b Key Laboratory of Genomic and Precision Medicine , China Gastrointestinal Cancer Research Center, Beijing Institute of Genomics, University of Chinese Academy of Sciences, Chinese Academy of Sciences , Beijing , China.
authors.forename: Yong-Liang
authors.initials: YL
authors.lastname: Zhao
authors.affiliation: a Key Laboratory of Genomic and Precision Medicine , Collaborative Innovation Center of Genetics and Development, CAS Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing , China.
authors.forename: Yun-Gui
authors.initials: YG
authors.lastname: Yang
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000378:metabolism; D017398:Alternative Splicing; D000818:Animals; D006801:Humans; D008745:Methylation; D011485:Protein Binding; D012326:RNA Splicing; D000072260:RNA Splicing Factors / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism*; D000068103:Serine-Arginine Splicing Factors / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D000072260:RNA Splicing Factors; D012333:RNA, Messenger; D000068103:Serine-Arginine Splicing Factors; C010223:N-methyladenosine; D000241:Adenosine
keywords: Alternative splicing; SRSF10; SRSF3; YTHDC1; m6A