title: Overexpression of p16(INK4a) in Mastocytosis (Urticarial Pigmentosa).
abstract: The expression of p16(INK4a) has been reported to induce cell-cycle arrest and cellular senescence. The p16(INK4a) expression has never been examined in human mast cells and mastocytosis. We immunohistologically examined the expression of p16(INK4a) and tryptase in 5 normal human skin and 4 mastocytosis. In normal mast cells, only 5.9 ± 3.4 (mean ± standard deviation) % of tryptase-positive mast cells coexpressed p16(INK4a). However, significantly higher percentage (86.0 ± 14.1%) of tryptase-positive tumor cells was immunoreactive to p16(INK4a) in all of 4 mastocytosis. The p16(INK4a) overexpression may induce the senescence of neoplastic mast cells to undergo spontaneous regression of mastocytosis.
authors.forename: Jun
authors.initials: J
authors.lastname: Tsujita
authors.forename: Kazuko
authors.initials: K
authors.lastname: Doi
authors.forename: Makiko
authors.initials: M
authors.lastname: Nakahara
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nakahara
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Kaku
authors.forename: Kiichiro
authors.initials: K
authors.lastname: Nishio
authors.forename: Nagisa
authors.initials: N
authors.lastname: Kan
authors.forename: Yuki
authors.initials: Y
authors.lastname: Sato
authors.forename: Shoko
authors.initials: S
authors.lastname: Nagata
authors.forename: Asako
authors.initials: A
authors.lastname: Nakao
authors.forename: Maiko
authors.initials: M
authors.lastname: Yoshida
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Uchi
authors.forename: Masutaka
authors.initials: M
authors.lastname: Furue
mesh_terms: D059447:Cell Cycle Checkpoints / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism; D016922:Cellular Senescence / Q000235:genetics; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D015870:Gene Expression; D006801:Humans; D008407:Mast Cells / Q000473:pathology; D034701:Mastocytosis, Cutaneous / Q000235:genetics / Q000473:pathology; D009365:Neoplasm Regression, Spontaneous / Q000235:genetics / Q000473:pathology; D012867:Skin / Q000378:metabolism / Q000473:pathology; D053802:Tryptases / Q000235:genetics / Q000378:metabolism; D014582:Urticaria Pigmentosa / Q000235:genetics* / Q000473:pathology
chemical_list: D019941:Cyclin-Dependent Kinase Inhibitor p16; D053802:Tryptases