title: Pediatric Erythema Annulare Centrifugum Treated with Oral Fluconazole: A Retrospective Series.
abstract: OBJECTIVE
  Erythema annulare centrifugum (EAC) is an uncommon eruption that may be a hypersensitivity reaction. Treatment of EAC is best accomplished by eliminating the underlying cause. Although many triggers have been reported, the inciting factor is unknown in most patients. We hypothesized that occult yeast overgrowth may trigger EAC in patients with EAC of unknown etiology.
  
  
  METHODS
  Five children with EAC were treated empirically with oral fluconazole. These cases were retrospectively reviewed.
  
  
  RESULTS
  Improvement was noted in all patients; three cleared entirely. Two patients experienced recurrences after successful treatment, which were treated with a second course of fluconazole. The treatment was well tolerated, without adverse effects.
  
  
  CONCLUSIONS
  Oral fluconazole was an effective treatment in five children with EAC.
authors.affiliation: Division of Dermatology, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. lkruse@luriechildrens.org.|Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois. lkruse@luriechildrens.org.
authors.forename: Lacey L
authors.initials: LL
authors.lastname: Kruse
authors.affiliation: Division of Dermatology, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.|Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.
authors.forename: Brandi M
authors.initials: BM
authors.lastname: Kenner-Bell
authors.affiliation: Division of Dermatology, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.|Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Mancini
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000935:Antifungal Agents / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004890:Erythema / Q000175:diagnosis* / Q000188:drug therapy*; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D012494:Sampling Studies; D012720:Severity of Illness Index; D012873:Skin Diseases, Genetic / Q000175:diagnosis* / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole