title: CXCR4 signaling in health and disease.
abstract: Chemokines and chemokine receptors regulate multiple processes such morphogenesis, angiogenesis and immune responses. Among the chemokine receptors, CXCR4 stands out for its pleiotropic roles as well as for its involvement in several pathological conditions, including immune diseases, viral infections and cancer. For these reasons, CXCR4 represents a crucial target in drug development. In this review, we discuss of CXCR4 receptor properties and signaling in health and diseases, focusing on the WHIM syndrome, an inherited immunodeficiency caused by mutations of the CXCR4 gene.
authors.affiliation: Department of Biomedical Sciences, University of Padua, Padua, Italy; Venetian Institute of Molecular Medicine (VIMM), Padova, Italy.
authors.forename: Tommaso
authors.initials: T
authors.lastname: Pozzobon
authors.affiliation: Venetian Institute of Molecular Medicine (VIMM), Padova, Italy.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Goldoni
authors.affiliation: Department of Biomedical Sciences, University of Padua, Padua, Italy; Venetian Institute of Molecular Medicine (VIMM), Padova, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Viola
authors.affiliation: Department of Biomedical Sciences, University of Padua, Padua, Italy; Venetian Institute of Molecular Medicine (VIMM), Padova, Italy. Electronic address: barbara.molon@unipd.it.
authors.forename: Barbara
authors.initials: B
authors.lastname: Molon
mesh_terms: D000818:Animals; D054377:Chemokine CXCL12 / Q000378:metabolism*; D006801:Humans; D007109:Immunity; D007153:Immunologic Deficiency Syndromes / Q000235:genetics / Q000276:immunology*; D009024:Morphogenesis; D009154:Mutation / Q000235:genetics; D018919:Neovascularization, Physiologic; D000081207:Primary Immunodeficiency Diseases; D011487:Protein Conformation; D019718:Receptors, CXCR4 / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D059467:Transcriptome; D014860:Warts / Q000235:genetics / Q000276:immunology*
chemical_list: D054377:Chemokine CXCL12; D019718:Receptors, CXCR4
keywords: CXCL12; CXCR4; Chemokine receptors; Immunity; Signaling pathway; WHIM syndrome