title: Borane-catalyzed metal-free hydrogenation of 2,7-disubstituted 1,8-naphthyridines.
abstract: Metal-free hydrogenation of 2,7-disubstituted 1,8-naphthyridines was successfully realized for the first time using in situ generated borane catalysts under mild conditions to furnish 1,2,3,4-tetrahydro-1,8-naphthyridine derivatives in 83-98% yields. Significantly, up to 74% ee was achieved for the corresponding asymmetric hydrogenation reactions.
authors.affiliation: Beijing National Laboratory of Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. haifengdu@iccas.ac.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Beijing National Laboratory of Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. haifengdu@iccas.ac.cn.
authors.forename: Xiangqing
authors.initials: X
authors.lastname: Feng
authors.affiliation: Beijing National Laboratory of Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. haifengdu@iccas.ac.cn.
authors.forename: Haifeng
authors.initials: H
authors.lastname: Du
mesh_terms: D001880:Boranes / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D006865:Hydrogenation; D009287:Naphthyridines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D020058:Styrene / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D001880:Boranes; D009287:Naphthyridines; D020058:Styrene