title: Metal-Catalyzed Annulations through Activation and Cleavage of C-H Bonds.
abstract: The exponential increase in the number of catalytic transformations that involve a metal-promoted activation of hitherto considered inert C-H bonds is promoting a fundamental change in the field of synthetic chemistry. Although most reactions involving C-H activations consist of simple functionalizations or additions, recent years have witnessed an upsurge in related transformations that can be formally considered as cycloaddition processes. These transformations are particularly appealing from a synthetic perspective because they allow the conversion of readily available substrates into highly valuable cyclic products in a rapid and sustainable manner. In many cases, these annulations involve the formation of metallacyclic intermediates that resemble those proposed for standard metal-catalyzed cycloadditions of unsaturated precursors.
authors.affiliation: Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS) and Departamento de Química Orgánica, 15782, Universidade de Santiago de Compostela, Spain. moises.gulias@usc.es.
authors.forename: Moisés
authors.initials: M
authors.lastname: Gulías
authors.affiliation: Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS) and Departamento de Química Orgánica, 15782, Universidade de Santiago de Compostela, Spain. joseluis.mascarenas@usc.es.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Mascareñas
keywords: C−H activation; cycloaddition; heterocycles; homogeneous catalysis; transition metals