title: Wearable Sensors in Huntington Disease: A Pilot Study.
abstract: The Unified Huntington's Disease Rating Scale (UHDRS) is the principal means of assessing motor impairment in Huntington disease but is subjective and generally limited to in-clinic assessments.
  
  
  
  To evaluate the feasibility and ability of wearable sensors to measure motor impairment in individuals with Huntington disease in the clinic and at home.
  
  
  
  Participants with Huntington disease and controls were asked to wear five accelerometer-based sensors attached to the chest and each limb for standardized, in-clinic assessments and for one day at home. A second chest sensor was worn for six additional days at home. Gait measures were compared between controls, participants with Huntington disease, and participants with Huntington disease grouped by UHDRS total motor score using Cohen's d values.
  
  
  
  Fifteen individuals with Huntington disease and five controls completed the study. Sensor data were successfully captured from 18 of the 20 participants at home. In the clinic, the standard deviation of step time (time between consecutive steps) was increased in Huntington disease (p < 0.0001; Cohen's d = 2.61) compared to controls. At home with additional observations, significant differences were observed in seven additional gait measures. The gait of individuals with higher total motor scores (50 or more) differed significantly from those with lower total motor scores (below 50) on multiple measures at home.
  
  
  
  In this pilot study, the use of wearable sensors in clinic and at home was feasible and demonstrated gait differences between controls, participants with Huntington disease, and participants with Huntington disease grouped by motor impairment.
authors.affiliation: Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA.
authors.forename: Kelly L
authors.initials: KL
authors.lastname: Andrzejewski
authors.affiliation: BioSensics LLC, Cambridge, MA, USA.
authors.forename: Ariel V
authors.initials: AV
authors.lastname: Dowling
authors.affiliation: Teva Pharmaceuticals, La Jolla, CA, USA.
authors.forename: David
authors.initials: D
authors.lastname: Stamler
authors.affiliation: CHET, University of Rochester Medical Center, Rochester, NY, USA.
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Felong
authors.affiliation: University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
authors.forename: Denzil A
authors.initials: DA
authors.lastname: Harris
authors.affiliation: Teva Pharmaceuticals, La Jolla, CA, USA.
authors.forename: Cynthia
authors.initials: C
authors.lastname: Wong
authors.affiliation: BioSensics LLC, Cambridge, MA, USA.
authors.forename: Hang
authors.initials: H
authors.lastname: Cai
authors.affiliation: Department of Neurodegenerative Diseases and Hertie-Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany.
authors.forename: Ralf
authors.initials: R
authors.lastname: Reilmann
authors.affiliation: Aston University, Birmingham, UK.|Massachusetts Institute of Technology, Cambridge, MA, USA.
authors.forename: Max A
authors.initials: MA
authors.lastname: Little
authors.affiliation: BioSensics LLC, Cambridge, MA, USA.
authors.forename: Joseph T
authors.initials: JT
authors.lastname: Gwin
authors.affiliation: Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA.|CHET, University of Rochester Medical Center, Rochester, NY, USA.
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Biglan
authors.affiliation: Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA.|CHET, University of Rochester Medical Center, Rochester, NY, USA.
authors.forename: E Ray
authors.initials: ER
authors.lastname: Dorsey
mesh_terms: D061725:Accelerometry; D000328:Adult; D000368:Aged; D015444:Exercise / Q000502:physiology*; D005260:Female; D005684:Gait / Q000502:physiology*; D006801:Humans; D006816:Huntington Disease / Q000175:diagnosis / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology*; D010865:Pilot Projects
keywords: Huntington disease; ambulatory monitoring; chorea; clinical study; gait; movement; remote sensing technology