title: Bio-nano interactions detected by nanochannel electrophoresis.
abstract: Engineered nanoparticles have been widely used in industry and are present in many consumer products. However, their bio-safeties especially in a long term are largely unknown. Here, a nanochannel-electrophoresis-based method is proposed for detecting the potential bio-nano interactions that may further lead to damages to human health and/or biological environment. Through proof-of-concept molecular dynamics simulations, it was demonstrated that the transport of a protein-nanoparticle complex is very different from that of a protein along. By monitoring the change of ionic currents induced by a transported analyte as well as the transport velocities of the analyte, the complex (with bio-nano interaction) can be clearly distinguished from the protein alone (with no interaction with tested nanoparticles).
authors.affiliation: Computational Biological Center, IBM Thomas J. Watson Research, Yorktown Heights, NY, USA.
authors.forename: Binquan
authors.initials: B
authors.lastname: Luan
mesh_terms: D004586:Electrophoresis / Q000295:instrumentation / Q000379:methods*; D056004:Molecular Dynamics Simulation; D053758:Nanoparticles / Q000737:chemistry*; D049329:Nanostructures; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry*
chemical_list: D011506:Proteins
keywords: Bio-nano; Biological sensor; Nanochannel