title: Biochemical parameters response to weight loss in patients with non-alcoholic steatohepatitis.
abstract: BACKGROUND
  Non-alcoholic steatohepatitis (NASH) is a chronic liver disease that is capable of progressing to end-stage liver disease, but generally has a benign course. Non-alcoholic steatohepatitis (NASH) is a growing public health problem with no approved therapy. NASH projected to be the leading cause of liver transplantation in the United States by 2020. Obesity, non-insulin-dependent diabetes mellitus and hyperlipidaemia are the most common associations of the disease. Global prevalence of NASH is 10-24% amongst general population but increases to 25-75% in obese diabetic individuals.
  
  
  OBJECTIVE
  There is an urgent need for efficient therapeutic options as there is still no approved medication. The aim of this study was to detect changes in biochemical parameters including insulin resistance, cytokines, blood lipid profile and liver enzymes following weight loss in patients with non-alcoholic steatohepatitis.
  
  
  METHODS
  One hundred obese patients with NASH, their age between 35-50 years, body mass index (BMI) from 30 to 35 Kg/m(2) were included in the study in two subgroups; the first group (A) received moderate aerobic exercise training in addition to diet regimen , where the second group (B) received no treatment intervention.
  
  
  RESULTS
  The mean values of leptin, TNF-α, IL6, IL8, Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), Homeostasis Model Assessment-Insulin Resistance- index (HOMA-IR), Total Cholesterol (TC), Low Density Lipoprotein Cholesterol (LDL-c) , Triglycerides (TG) and BMI were significantly decreased in group (A), where the mean value of Adiponectin and High Density Lipoprotein Cholesterol (HDL-c) were significantly increased, while there were no significant changes in group (B). Also, there was a significant difference between both groups at the end of the study.
  
  
  CONCLUSIONS
  Weight loss modulates insulin resistance, adiponectin, leptin, inflammatory cytokine levels and markers of hepatic function in patients with nonalcoholic steatohepatitis.
authors.affiliation: Department of Physical Therapy, Faculty of Applied Medical Sciences, King Abdulaziz University.
authors.forename: Shehab M
authors.initials: SM
authors.lastname: Abd El-Kader
authors.affiliation: Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University.
authors.forename: Fadwa M
authors.initials: FM
authors.lastname: Al-Shreef
authors.affiliation: Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University.
authors.forename: Osama H
authors.initials: OH
authors.lastname: Al-Jiffri
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers; D015992:Body Mass Index; D048909:Diabetes Complications; D004032:Diet; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology; D007378:Interleukins / Q000097:blood; D020738:Leptin / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood* / Q000150:complications; D009765:Obesity / Q000150:complications; D016037:Single-Blind Method; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D015431:Weight Loss / Q000502:physiology*; D061217:Weight Reduction Programs / Q000379:methods
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D007378:Interleukins; D020738:Leptin; D008055:Lipids; D014409:Tumor Necrosis Factor-alpha; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
keywords: Weight loss; cytokines; insulin resistance; liver enzymes; nonalcoholic steatohepatitis