title: Active tumor-targeting luminescent gold clusters with efficient urinary excretion.
abstract: We present novel active targeting luminescent gold nanoclusters (AuNCs), which are prepared through a one-pot procedure by using a pentapeptide (CRGDS) for stabilization and tumor recognition. CRGDS-AuNCs exhibit a high tumor-specific retention with an exceptionally high tumor-to-liver uptake ratio of 9.3. Their small hydrodynamic diameter and zwitterionic surface facilitate urinary excretion, which reaches 82% within 24 h after injection.
authors.affiliation: State Key Laboratory of Heavy Oil Processing, China University of Petroleum (East China), Qingdao 266580, China. fhuang@upc.edu.cn.
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Wang
authors.forename: Hua
authors.initials: H
authors.lastname: He
authors.forename: Yanan
authors.initials: Y
authors.lastname: Wang
authors.forename: Junying
authors.initials: J
authors.lastname: Wang
authors.forename: Xing
authors.initials: X
authors.lastname: Sun
authors.forename: Hai
authors.initials: H
authors.lastname: Xu
authors.forename: Werner M
authors.initials: WM
authors.lastname: Nau
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Zhang
authors.forename: Fang
authors.initials: F
authors.lastname: Huang
mesh_terms: D006046:Gold / Q000737:chemistry*; D049449:Luminescence; D053768:Metal Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000652:urine*; D009842:Oligopeptides / Q000737:chemistry; D050607:Organogold Compounds / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D009842:Oligopeptides; D050607:Organogold Compounds; D006046:Gold