title: The efficacy of resveratrol in controlling hypertension: study protocol for a randomized, crossover, double-blinded, placebo-controlled trial.
abstract: Hypertension is a global health concern for which novel treatment strategies are necessary. The aim of this study is to evaluate the efficacy of resveratrol (trans-3, 5, 4'-trihydroxystilbene, a polyphenol present in grapes) in controlling blood pressure in participants diagnosed with prehypertension and stage 1 hypertension.
  
  
  
  In a randomized, crossover, double-blinded, placebo-controlled study, 50 participants with prehypertension (diastolic blood pressure and systolic blood pressure, 80-89 mmHg and 120-139 mmHg, respectively) and 50 participants with stage 1 hypertension (diastolic and systolic, 90-99 mmHg and 140-159 mmHg, respectively) will be assigned to receive resveratrol (99 % pure, from Biotivia Longevity Bioceuticals LLC Company, USA, in 500 mg capsules, twice daily for 4 weeks, orally) or placebo (500 mg neutral microcellulose capsules, twice daily for 4 weeks) in a 2 × 2 crossover design (4 weeks treatment-4 weeks washout-4 weeks treatment). The blood pressure of each participant will be recorded (a mean of two times within a 15-minute interval) every week during the study. The participants in the prehypertensive group will not receive any medication, while those in the stage 1 hypertensive group will continue to receive their routine medications during the study. Blood samples will be taken from all groups and examined for various biochemical parameters.
  
  
  
  This trial will help to establish whether resveratrol is an effective antihypertensive agent in prehypertensive and stage 1-hypertensive patients. The trial outcome will provide novel insight into the clinical efficacy of resveratrol and provide valuable information for conducting future clinical studies with resveratrol.
  
  
  
  Iranian Registry of Clinical Trials, IRCT201407078129N7. Registered on 15 August 2014.
authors.affiliation: The Persian Gulf Tropical Medicine Research Center, Biochemistry Group, Bushehr University of Medical Sciences, Bushehr, Iran. amovahed58@gmail.com.
authors.forename: Ali
authors.initials: A
authors.lastname: Movahed
authors.affiliation: The Persian Gulf Tropical Medicine Research Center, Biochemistry Group, Bushehr University of Medical Sciences, Bushehr, Iran.
authors.forename: Afshin
authors.initials: A
authors.lastname: Ostovar
authors.affiliation: Department of Cardiology, Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran.
authors.forename: Daryoush
authors.initials: D
authors.lastname: Iranpour
authors.affiliation: Agriculture and Agri-Food Canada, Winnipeg, Manitoba, R3T 2M9, Canada.
authors.forename: Sijo Joseph
authors.initials: SJ
authors.lastname: Thandapilly
authors.affiliation: Canadian Centre for Agri-Food Research in Health and Medicine, Winnipeg, R2H 2A6, Canada.|Agriculture and Agri-Food Canada, Winnipeg, Manitoba, R3T 2M9, Canada.|Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Manitoba, R3E 0J9, Canada.
authors.forename: Pema
authors.initials: P
authors.lastname: Raj
authors.affiliation: Canadian Centre for Agri-Food Research in Health and Medicine, Winnipeg, R2H 2A6, Canada.|Agriculture and Agri-Food Canada, Winnipeg, Manitoba, R3T 2M9, Canada.|Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Manitoba, R3E 0J9, Canada.
authors.forename: Xavier Lieben
authors.initials: XL
authors.lastname: Louis
authors.affiliation: Department of Physical Therapy, High Point University, High Point, NC, 27262, USA.|Department of Basic Pharmaceutical Sciences, High Point University, High Point, NC, 27262, USA.
authors.forename: James Michael
authors.initials: JM
authors.lastname: Smoliga
authors.affiliation: Department of Cardiology, Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran. tnetticadan@sbrc.ca.|Agriculture and Agri-Food Canada, Winnipeg, Manitoba, R3T 2M9, Canada. tnetticadan@sbrc.ca.|Heart Failure Research Laboratory, Canadian Centre for Agri-Food Research in Health and Medicine, R2035, St. Boniface Research Centre, 351 Tache Avenue, Winnipeg, Manitoba, R2H 2A6, Canada. tnetticadan@sbrc.ca.
authors.forename: Thomas
authors.initials: T
authors.lastname: Netticadan
mesh_terms: D002985:Clinical Protocols; D018592:Cross-Over Studies; D004311:Double-Blind Method; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D017063:Outcome Assessment, Health Care; D000077185:Resveratrol; D018401:Sample Size; D013267:Stilbenes / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D013267:Stilbenes; D000077185:Resveratrol
keywords: Blood pressure; Hypertension; Polyphenol; Resveratrol