title: Ovariectomy changes the response to antidepressant drugs in tail suspension test in mice.
abstract: Depressive symptoms are very frequent over a lifetime, especially for women. Menopause is a period of higher depressive vulnerability. There are suggestive data that estrogen deficiency may increase the susceptibility for depression. We studied whether a bilateral ovariectomy (OVX) modifies mice behaviors and antidepressant drug effects through tail suspension test (TST). We evaluated behavioral changes at 1 week, 2 weeks, and up to 2 months after OVX. The behavior responses to doxepin, paroxetine, and venlafaxine at 1 week, 2 weeks, and 2 months after OVX were evaluated. No obvious difference was detected on the duration of immobility among control group, sham group, and OVX group in the TST at 1 week and 2 weeks after OVX. But the duration of immobility of OVX group was distinctly longer than that of both control group and sham operation group at 2 months after OVX. At 1 and 2 weeks after OVX, only the antidepressant response to venlafaxine was observed, while response to paroxetine increased 2 months after OVX. Response to antidepressant drugs was strongly modified in OVX mice. The present results suggest that not all antidepressant drugs are appropriate for depression with estrogen deficiency.
authors.affiliation: a Department of Neuroscience , Institute for Chinese Medicine , Heilongjiang University of Chinese Medicine, Harbin , China.|b Graduate School, Beijing University of Chinese Medicine , Beijing , China.|c Department of Acupuncture and Moxibustion , Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University , Beijing , China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Ye
authors.affiliation: c Department of Acupuncture and Moxibustion , Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University , Beijing , China.
authors.forename: Cunzhi
authors.initials: C
authors.lastname: Liu
authors.affiliation: a Department of Neuroscience , Institute for Chinese Medicine , Heilongjiang University of Chinese Medicine, Harbin , China.
authors.forename: Xuewei
authors.initials: X
authors.lastname: Liu
authors.affiliation: a Department of Neuroscience , Institute for Chinese Medicine , Heilongjiang University of Chinese Medicine, Harbin , China.
authors.forename: Shuming
authors.initials: S
authors.lastname: Huang
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D003863:Depression / Q000188:drug therapy* / Q000378:metabolism; D004195:Disease Models, Animal; D004316:Doxepin / Q000008:administration & dosage / Q000494:pharmacology*; D004967:Estrogens / Q000378:metabolism; D005260:Female; D019417:Hindlimb Suspension; D008593:Menopause / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D010052:Ovariectomy / Q000009:adverse effects*; D017374:Paroxetine / Q000008:administration & dosage / Q000494:pharmacology*; D000069470:Venlafaxine Hydrochloride / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000928:Antidepressive Agents; D004967:Estrogens; D004316:Doxepin; D017374:Paroxetine; D000069470:Venlafaxine Hydrochloride
keywords: Antidepressant drug; menopause; ovariectomy; ovary; tail suspension test