title: Association of single nucleotide polymorphism rs3803662 with the risk of breast cancer.
abstract: Large scale association studies have identified the single nucleotide polymorphism rs3803662 associated with breast cancer risk. However, the sample size of most studies is too small. Here, we performed this meta-analysis to make the result more convincing. Relevant articles published up to 2016 were identified by searching the PubMed database. 13 studies, involving a total of 29405 participants, were included in the meta-analysis. Odds Ratios (ORs) with 95% confidence intervals (CIs) was calculated with random or fixed effects model. All data analyses were analyzed by Review Manger 5.3 software. In Caucasian subgroup: Dominant model (TT + CT vs CC): OR = 1.17 (1.06, 1.29), Recessive model (TT vs CT + CC): OR = 1.25 (1.13, 1.39) and Allele frequency (T vs C): OR = 1.15 (1.08, 1.22). The present meta-analysis suggests that rs3803662 polymorphism is significantly associated with breast cancer risk in Caucasian women, and we did not find the association in Asian women.
authors.affiliation: College of Life Sciences, Northwest A&F University, Yangling, Shaanxi, China.|School of Life Sciences, Fudan University, Shanghai, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Yang
authors.affiliation: College of Life Sciences, Northwest A&F University, Yangling, Shaanxi, China.|Research Center for Translation Medicine, East Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Wenjing
authors.initials: W
authors.lastname: Wang
authors.affiliation: School of Life Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang, China.
authors.forename: Guiyou
authors.initials: G
authors.lastname: Liu
authors.affiliation: College of Natural Resources and Environment, Northwest A&F University, Yangling, Shaanxi, China.
authors.forename: Yingcui
authors.initials: Y
authors.lastname: Yu
authors.affiliation: College of Life Sciences, Northwest A&F University, Yangling, Shaanxi, China.
authors.forename: Mingzhi
authors.initials: M
authors.lastname: Liao
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D001943:Breast Neoplasms / Q000208:ethnology / Q000235:genetics*; D016001:Confidence Intervals; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D016014:Linear Models; D008957:Models, Genetic; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias; D012306:Risk; D044465:White People / Q000235:genetics