title: ABOUT PATIENTS, "INVENTORS", JOURNALISTS, SCIENTISTS AND IRBs (TO SAY NOTHING OF THE INSTITUTIONS): CCSVI AND MS.
abstract: In this article, the Author analyzes her own experience as a member of the IRB that approved a trial to determine the efficacy of a disobstruction procedure of extracranial veins by means of angioplasty in patients with multiple sclerosis (MS). The so-called "liberation therapy" was proposed by an Italian vascular surgeon, who theorized a condition called "chronic cerebrospinal venous insufficiency" (CCSVI) as playing a role in the pathogenesis of MS. This approval, given after an animated discussion amongst IRB members, lacked any solid scientific evidence of a causal relationship between CCSVI and MS, and was accepted despite the concerns about potential risks associated with the proposed therapy. Undoubtedly, considerable pressure was exerted on IRB by MS sufferers, who rushed off to get the surgery from the many clinics who offered liberation therapy.The remaining sense of bitter has raised a reflection on how to prevent similar future cases.
authors.forename: M Antonella
authors.initials: MA
authors.lastname: Piga
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D017130:Angioplasty / Q000941:ethics / Q000331:legislation & jurisprudence*; D001921:Brain / Q000098:blood supply*; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D057176:Compassionate Use Trials / Q000941:ethics / Q000331:legislation & jurisprudence*; D028744:Ethics Committees, Research / Q000941:ethics / Q000331:legislation & jurisprudence*; D004992:Ethics, Medical; D005260:Female; D005607:Fraud / Q000331:legislation & jurisprudence; D006801:Humans; D007558:Italy; D018156:Journalism, Medical; D008297:Male; D017056:Medical Laboratory Personnel / Q000941:ethics / Q000331:legislation & jurisprudence*; D009103:Multiple Sclerosis / Q000209:etiology / Q000628:therapy*; D014897:Spinal Muscular Atrophies of Childhood / Q000209:etiology / Q000628:therapy*; D033581:Stem Cell Transplantation / Q000941:ethics / Q000331:legislation & jurisprudence*; D014689:Venous Insufficiency / Q000209:etiology / Q000628:therapy*