title: Size-dependent cytotoxicity of copper oxide nanoparticles in lung epithelial cells.
abstract: The increasing use of copper oxide (CuO) nanoparticles (NPs) in medicine and industry demands an understanding of their potential toxicities. In this study, we compared thein vitrocytotoxicity of CuO NPs of two distinct sizes (4 and 24 nm) using the A549 human lung cell line. Despite possessing similar surface and core oxide compositions, 24 nm CuO NPs were significantly more cytotoxic than 4 nm CuO NPs. The difference in size may have affected the rate of entry of NPs into the cell, potentially influencing the amount of intracellular dissolution of Cu2+and causing a differential impact on cytotoxicity.
authors.affiliation: Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa city, IA 52242, United States; Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand; Center of Excellence in Innovative Drug Delivery and Nanomedicine, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand.
authors.forename: Amaraporn
authors.initials: A
authors.lastname: Wongrakpanich
authors.affiliation: Department of Chemistry, University of Iowa, Iowa city, IA 52242, United States.
authors.forename: Imali A
authors.initials: IA
authors.lastname: Mudunkotuwa
authors.affiliation: Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa city, IA 52242, United States.
authors.forename: Sean M
authors.initials: SM
authors.lastname: Geary
authors.affiliation: Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa city, IA 52242, United States; Department of Chemistry, University of Iowa, Iowa city, IA 52242, United States.
authors.forename: Angie S
authors.initials: AS
authors.lastname: Morris
authors.affiliation: Department of Radiation Oncology, Carver College of Medicine, University of Iowa, Iowa city, IA 52242, United States.
authors.forename: Kranti A
authors.initials: KA
authors.lastname: Mapuskar
authors.affiliation: Department of Radiation Oncology, Carver College of Medicine, University of Iowa, Iowa city, IA 52242, United States.
authors.forename: Douglas R
authors.initials: DR
authors.lastname: Spitz
authors.affiliation: Department of Chemistry, University of Iowa, Iowa city, IA 52242, United States; Departments of Chemistry and Biochemistry, Nanoengineering and the Scripps Institution of Oceanography, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093, United States.
authors.forename: Vicki H
authors.initials: VH
authors.lastname: Grassian
authors.affiliation: Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa city, IA 52242, United States.
authors.forename: Aliasger K
authors.initials: AK
authors.lastname: Salem
keywords: A549; Copper oxide; nanoparticles; toxicity