title: Reconstruction and Application of Protein-Protein Interaction Network.
abstract: The protein-protein interaction network (PIN) is a useful tool for systematic investigation of the complex biological activities in the cell. With the increasing interests on the proteome-wide interaction networks, PINs have been reconstructed for many species, including virus, bacteria, plants, animals, and humans. With the development of biological techniques, the reconstruction methods of PIN are further improved. PIN has gradually penetrated many fields in biological research. In this work we systematically reviewed the development of PIN in the past fifteen years, with respect to its reconstruction and application of function annotation, subsystem investigation, evolution analysis, hub protein analysis, and regulation mechanism analysis. Due to the significant role of PIN in the in-depth exploration of biological process mechanisms, PIN will be preferred by more and more researchers for the systematic study of the protein systems in various kinds of organisms.
authors.affiliation: Tianjin Key Laboratory of Animal and Plant Resistance/College of Life Sciences, Tianjin Normal University, Tianjin 300387, China. joyht2001@163.com.
authors.forename: Tong
authors.initials: T
authors.lastname: Hao
authors.affiliation: Tianjin Key Laboratory of Animal and Plant Resistance/College of Life Sciences, Tianjin Normal University, Tianjin 300387, China. crystal6062@163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Peng
authors.affiliation: Tianjin Key Laboratory of Animal and Plant Resistance/College of Life Sciences, Tianjin Normal University, Tianjin 300387, China. 18222565925@163.com.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Tianjin Key Laboratory of Animal and Plant Resistance/College of Life Sciences, Tianjin Normal University, Tianjin 300387, China. wbkjc@mail.tjnu.edu.cn.
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.affiliation: Tianjin Key Laboratory of Animal and Plant Resistance/College of Life Sciences, Tianjin Normal University, Tianjin 300387, China. jinshsun@163.com.|Tianjin Aquatic Animal Infectious Disease Control and Prevention Center, Tianjin 300221, China. jinshsun@163.com.
authors.forename: Jinsheng
authors.initials: J
authors.lastname: Sun
mesh_terms: D000818:Animals; D005075:Biological Evolution; D005057:Eukaryotic Cells / Q000378:metabolism; D006801:Humans; D010944:Plants / Q000378:metabolism; D011387:Prokaryotic Cells / Q000378:metabolism; D025941:Protein Interaction Mapping / Q000379:methods; D060066:Protein Interaction Maps; D020543:Proteome; D040901:Proteomics / Q000379:methods; D014780:Viruses / Q000378:metabolism
chemical_list: D020543:Proteome
keywords: interactome; protein–protein interaction network; proteome; reconstruction technique