title: Temporal Lobe Epilepsy Alters Auditory-motor Integration For Voice Control.
abstract: Temporal lobe epilepsy (TLE) is the most common drug-refractory focal epilepsy in adults. Previous research has shown that patients with TLE exhibit decreased performance in listening to speech sounds and deficits in the cortical processing of auditory information. Whether TLE compromises auditory-motor integration for voice control, however, remains largely unknown. To address this question, event-related potentials (ERPs) and vocal responses to vocal pitch errors (1/2 or 2 semitones upward) heard in auditory feedback were compared across 28 patients with TLE and 28 healthy controls. Patients with TLE produced significantly larger vocal responses but smaller P2 responses than healthy controls. Moreover, patients with TLE exhibited a positive correlation between vocal response magnitude and baseline voice variability and a negative correlation between P2 amplitude and disease duration. Graphical network analyses revealed a disrupted neuronal network for patients with TLE with a significant increase of clustering coefficients and path lengths as compared to healthy controls. These findings provide strong evidence that TLE is associated with an atypical integration of the auditory and motor systems for vocal pitch regulation, and that the functional networks that support the auditory-motor processing of pitch feedback errors differ between patients with TLE and healthy controls.
authors.affiliation: Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
authors.forename: Weifeng
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
authors.forename: Ziyi
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Ambient Intelligence and Multimodal Systems Lab, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences Shenzhen, 518055, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Yan
authors.affiliation: Psychology Department and Laurier Centre for Cognitive Neuroscience, Wilfrid Laurier University, Waterloo, Ontario, N2L 3C5, Canada.
authors.forename: Jeffery A
authors.initials: JA
authors.lastname: Jones
authors.affiliation: Department of Biomedical Engineering, School of Engineering, Sun Yat-sen University, Guangzhou, 510006, China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Guo
authors.affiliation: Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
authors.forename: Xiyan
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
authors.forename: Shaozhen
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Liu
authors.affiliation: Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.|Guangdong Provincial Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
authors.forename: Hanjun
authors.initials: H
authors.lastname: Liu
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D016022:Case-Control Studies; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000503:physiopathology*; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D010898:Pitch Perception / Q000502:physiology; D055815:Young Adult