title: Gender and laterality in semicircular canal dehiscence syndrome.
abstract: OBJECTIVE
  To determine if there is gender or laterality predilection in patients with semicircular canal dehiscence syndrome.
  
  
  METHODS
  A multi-institutional chart review was performed to identify patients diagnosed with semicircular canal dehiscence between 2000 and 2015. A systematic literature search was conducted using PubMed to further identify patients with semicircular canal dehiscence. Age, gender and laterality data were collected. Statistical analysis was performed to evaluate for gender or laterality preponderance.
  
  
  RESULTS
  A total of 682 patients with semicircular canal dehiscence were identified by literature and chart review. Mean age of diagnosis was 49.75 years (standard deviation = 15.33). Semicircular canal dehiscence was associated with a statistically significant female predominance (chi-square = 7.185, p = 0.007); the female-to-male ratio was 1.2 to 1. Left-sided semicircular canal dehiscence was most common, followed by right-sided then bilateral (chi-square = 23.457, p < 0.001).
  
  
  CONCLUSIONS
  Semicircular canal dehiscence syndrome is most commonly left-sided and exhibits a female predominance. This may be secondary to morphological cerebral hemisphere asymmetries in both sexes and a predilection of women to seek more medical care than men.
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery,Saint Louis University School of Medicine,Missouri,USA.
authors.forename: K
authors.initials: K
authors.lastname: Karimnejad
authors.affiliation: Ear, Nose, and Throat Institute of Southern Illinois,Swansea,USA.
authors.forename: M S
authors.initials: MS
authors.lastname: Czerny
authors.affiliation: Department of Otolaryngology,University of Rochester Medical Center,New York,USA.
authors.forename: S
authors.initials: S
authors.lastname: Lookabaugh
authors.affiliation: Department of Otology and Laryngology,Massachusetts Eye and Ear Infirmary,Boston,USA.
authors.forename: D J
authors.initials: DJ
authors.lastname: Lee
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery,Saint Louis University School of Medicine,Missouri,USA.
authors.forename: A A
authors.initials: AA
authors.lastname: Mikulec
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D007839:Functional Laterality; D006314:Hearing Loss, Conductive / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012665:Semicircular Canals / Q000503:physiopathology*; D012737:Sex Factors; D014717:Vertigo / Q000503:physiopathology*; D055815:Young Adult
keywords: Conductive; Health Status; Hearing Loss; Parietal Lobe; Semicircular Canals; Temporal Lobe; Vertigo