title: Association between intake of antioxidants and pancreatic cancer risk: a meta-analysis.
abstract: We conducted a meta-analysis to systematically evaluate the association between antioxidants intake and pancreatic cancer risk. Relevant articles were retrieved from PUBMED and EMBASE databases and standard meta-analysis methods were applied. Finally a total of 18 studies were included. Comparing the highest with lowest categories, higher dietary intakes of selenium, vitamin C, vitamin E, β-carotene and β-cryptoxanthin were significantly associated with reduced pancreatic cancer risk (for selenium, pooled OR = 0.47, 95%CI 0.26-0.85; for vitamin C, pooled OR = 0.68, 95%CI 0.57-0.80; for vitamin E, pooled OR = 0.70, 95%CI 0.62-0.81; for β-carotene, pooled OR = 0.74, 95%CI 0.56-0.98; for β-cryptoxanthin, pooled OR = 0.70, 95%CI 0.56-0.88). Lycopene intake was marginally associated with pancreatic cancer risk (pooled OR = 0.85, 95%CI 0.73-1.00), while no significant association was observed for α-carotene, lutein and zeaxanthin. In summary, higher dietary intake of selenium, vitamin C, vitamin E, β-carotene and β-cryptoxanthin was inversely associated with pancreatic cancer risk.
authors.affiliation: a Department of Gastroenterology , Second Affiliated Hospital, Zhejiang University College of Medicine , Hangzhou , China ;
authors.forename: Jiamin
authors.initials: J
authors.lastname: Chen
authors.affiliation: a Department of Gastroenterology , Second Affiliated Hospital, Zhejiang University College of Medicine , Hangzhou , China ;
authors.forename: Wuxia
authors.initials: W
authors.lastname: Jiang
authors.affiliation: a Department of Gastroenterology , Second Affiliated Hospital, Zhejiang University College of Medicine , Hangzhou , China ;
authors.forename: Liming
authors.initials: L
authors.lastname: Shao
authors.affiliation: a Department of Gastroenterology , Second Affiliated Hospital, Zhejiang University College of Medicine , Hangzhou , China ;
authors.forename: Dandan
authors.initials: D
authors.lastname: Zhong
authors.affiliation: b Department of Epidemiology and Health Statistics , Zhejiang University School of Public Health , Hangzhou , China.
authors.forename: Yihua
authors.initials: Y
authors.lastname: Wu
authors.affiliation: a Department of Gastroenterology , Second Affiliated Hospital, Zhejiang University College of Medicine , Hangzhou , China ;
authors.forename: Jianting
authors.initials: J
authors.lastname: Cai
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000008:administration & dosage; D000072743:Beta-Cryptoxanthin / Q000008:administration & dosage; D002338:Carotenoids / Q000008:administration & dosage; D016208:Databases, Factual; D004032:Diet; D006801:Humans; D014975:Lutein / Q000008:administration & dosage; D000077276:Lycopene; D010190:Pancreatic Neoplasms / Q000453:epidemiology*; D012307:Risk Factors; D012643:Selenium / Q000008:administration & dosage; D014810:Vitamin E / Q000008:administration & dosage; D065146:Zeaxanthins / Q000008:administration & dosage; D019207:beta Carotene / Q000008:administration & dosage
chemical_list: D000975:Antioxidants; D000072743:Beta-Cryptoxanthin; D065146:Zeaxanthins; D019207:beta Carotene; D014810:Vitamin E; D002338:Carotenoids; C041635:alpha-carotene; D012643:Selenium; D001205:Ascorbic Acid; D000077276:Lycopene; D014975:Lutein
keywords: Antioxidant; association; intake; pancreatic cancer; risk