title: Artificial Organelles: Reactions inside Protein-Polymer Supramolecular Assemblies.
abstract: Reactions inside confined compartments at the nanoscale represent an essential step in the development of complex multifunctional systems to serve as molecular factories. In this respect, the biomimetic approach of combining biomolecules (proteins, enzymes, mimics) with synthetic membranes is an elegant way to create functional nanoreactors, or even simple artificial organelles, that function inside cells after uptake. Functionality is provided by the specificity of the biomolecule(s), whilst the synthetic compartment provides mechanical stability and robustness. The availability of a large variety of biomolecules and synthetic membranes allows the properties and functionality of these reaction spaces to be tailored and adjusted for building complex self-organized systems as the basis for molecular factories.
authors.affiliation: University of Basel, Department of Chemistry, Klingelbergstrasse 80, CH-4056 Basel, Switzerland.
authors.forename: Martina
authors.initials: M
authors.lastname: Garni
authors.affiliation: University of Basel, Department of Chemistry, Klingelbergstrasse 80, CH-4056 Basel, Switzerland.
authors.forename: TomaŽ
authors.initials: T
authors.lastname: Einfalt
authors.affiliation: University of Basel, Department of Chemistry, Klingelbergstrasse 80, CH-4056 Basel, Switzerland.
authors.forename: Mihai
authors.initials: M
authors.lastname: Lomora
authors.affiliation: University of Basel, Department of Chemistry, Klingelbergstrasse 80, CH-4056 Basel, Switzerland.
authors.forename: Anja
authors.initials: A
authors.lastname: Car
authors.affiliation: University of Basel, Department of Chemistry, Klingelbergstrasse 80, CH-4056 Basel, Switzerland. wolfgang.meier@unibas.ch.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Meier
authors.affiliation: University of Basel, Department of Chemistry, Klingelbergstrasse 80, CH-4056 Basel, Switzerland. cornelia.palivan@unibas.ch.
authors.forename: Cornelia G
authors.initials: CG
authors.lastname: Palivan
mesh_terms: D036103:Nanotechnology; D015388:Organelles; D010539:Permeability; D011108:Polymers / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*
chemical_list: D011108:Polymers; D011506:Proteins