title: The dynamics of the HIV epidemic among men who have sex with men (MSM) from 2005 to 2012 in Shenzhen, China.
abstract: HIV-1 epidemics among MSM are a major public health concern in China, especially in large cities. This study sought to better understand the dynamics of HIV molecular epidemiology among MSM in Shenzhen, a rapidly developing city with over 13.8 million people. HIV-1 pol sequences were obtained from 996 (53.5%) of 1862 HIV-infected MSM and 403(9.0%) of 4498 heterosexuals and injection drug users in Shenzhen, China from 2005-2012. Eight HIV-1 subtypes and some inter-subtype recombinants were identified among sampled MSM with CRF07_BC (39.1%) and CRF01_AE (35.1%) being the most predominant. From 2006 to 2012, the prevalence of CRF07_BC and CRF55_01B rapidly increased, while the prevalence of subtypes B and CRF01_AE gradually decreased. The genetic distances within CRF07_BC and CRF55_01B groups were significantly lower than within CRF01_AE and B groups. The vast majority (90.3%) of HIV-1 infected MSM in Shenzhen were migrants who came from 31 of the 34 provinces of China, and these migrants had significantly different HIV-1 subtype distributions from the local MSM. This study highlighted the importance of CRF07_BC and migrants in the changing HIV epidemic among MSM in China, and provides a molecular epidemiology framework for understanding how HIV-1 epidemics can change in large cities with diverse risk groups.
authors.affiliation: Shenzhen Center for Disease Control and Prevention, Shenzhen, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Shenzhen Center for Disease Control and Prevention, Shenzhen, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Chen
authors.affiliation: University of California San Diego, La Jolla, California, USA.|Veterans Affairs Healthcare System San Diego, San Diego, California, USA.
authors.forename: Antoine
authors.initials: A
authors.lastname: Chaillon
authors.affiliation: Shenzhen Center for Disease Control and Prevention, Shenzhen, China.
authors.forename: Chenli
authors.initials: C
authors.lastname: Zheng
authors.affiliation: Shenzhen Center for Disease Control and Prevention, Shenzhen, China.
authors.forename: Wende
authors.initials: W
authors.lastname: Cai
authors.affiliation: Shenzhen Center for Disease Control and Prevention, Shenzhen, China.
authors.forename: Zhengrong
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Shenzhen Center for Disease Control and Prevention, Shenzhen, China.
authors.forename: Guilian
authors.initials: G
authors.lastname: Li
authors.affiliation: Shenzhen Center for Disease Control and Prevention, Shenzhen, China.
authors.forename: Yongxia
authors.initials: Y
authors.lastname: Gan
authors.affiliation: Shenzhen Center for Disease Control and Prevention, Shenzhen, China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Wang
authors.affiliation: Pathogen Diagnostic Center, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
authors.forename: Yihong
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhong
authors.affiliation: University of California San Diego, La Jolla, California, USA.|Veterans Affairs Healthcare System San Diego, San Diego, California, USA.|Pathogen Diagnostic Center, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
authors.forename: Chiyu
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Veterans Affairs Healthcare System San Diego, San Diego, California, USA.|Pathogen Diagnostic Center, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
authors.forename: Davey M
authors.initials: DM
authors.lastname: Smith
mesh_terms: D002681:China / Q000453:epidemiology; D006679:HIV Seropositivity / Q000453:epidemiology* / Q000235:genetics*; D015497:HIV-1 / Q000235:genetics*; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D000072339:Sexual and Gender Minorities; D054302:pol Gene Products, Human Immunodeficiency Virus
chemical_list: D054302:pol Gene Products, Human Immunodeficiency Virus