title: Immune Reconstitution Inflammatory Syndrome and Shingles Associated with a Combined Paralysis of Three Oculomotor Nerves: A Case Report.
abstract: BACKGROUND
  In countries with high prevalence of HIV/AIDS infection, particularly in black Africa, shingles is one of the main opportunistic infections during immunosuppression due to AIDS in young patients. If immunological weakness is important, usually when the CD4 cell count is less than 100 cells/mm(3), the risk of inflammatory reactions in the first three months after initiating of antiretroviral treatment (ART) is very high. This inflammatory reaction is called immune reconstitution inflammatory syndrome (IRIS). This observation reports the first documented case of IRIS with V1 shingles in a young HIV patient at University Hospital of Brazzaville.
  
  
  METHODS
  A 40 years old patient was seen for a pain of the right side of the face and a complete immobility of the eyeball. The diagnosis of V1 shingles with a pan uveitis, and a paralysis of III, IV and VI nerves was made. The patiants HIV status was positive and CD4 cell count was 150 cells/mm(3). After two months of evolution under ART with a CD4 count of 850 cells /mm(3), the symptomatology was quickly complicated by significant inflammation causing a phtisis bulbi.
  
  
  CONCLUSIONS
  CD4 cells count is an important indicator in the HIV/AIDS therapy. In some major forms of IRIS, momentary pause of anti retroviral treatment is sometimes necessary.
authors.affiliation: Department of Ophthalmology, University Hospital of Brazzaville.
authors.forename: P W
authors.initials: PW
authors.lastname: Atipo-Tsiba
authors.affiliation: Department of Medicinel (Dermatology unit), Talangaï Hospital of Brazzaville.
authors.forename: E S
authors.initials: ES
authors.lastname: Kombo Bayonne
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000209:etiology; D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes; D005123:Eye / Q000473:pathology; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy*; D006562:Herpes Zoster / Q000209:etiology*; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000473:pathology*; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D007249:Inflammation / Q000209:etiology; D008297:Male; D009802:Oculomotor Nerve / Q000473:pathology; D015840:Oculomotor Nerve Diseases / Q000209:etiology*; D014605:Uveitis / Q000209:etiology
chemical_list: D019380:Anti-HIV Agents
keywords: AIDS; Immune reconstitution Inflammatory Syndrome; Oculomotor Nerves Paralysis; Shingles