title: Spontaneous Maturation of Neuroblastoma to Ganglioneuroma: Two Case Studies.
abstract: We describe two children with ganglioneuroma (GN) likely originating from incompletely resected neuroblastoma (NB) during infancy, stages 2A and 2B, who did not undergo postoperative adjuvant chemotherapies. Both NB tumors had no MYCN amplification, had TrKA but no TrkB expression, and by TUNEL had apoptosis. These findings may have contributed to spontaneous maturation of the residual primary NB and hence the favorable prognosis, which suggests surgery alone might be the sufficient initial therapy for low-risk patients.
authors.affiliation: a Department of Pathology , Shandong Provincial Hospital Affiliated to Shandong University , Jinan , China.
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Yao
authors.affiliation: b Department of Pathology , Qi Lu Children's Hospital of Shandong University , Jinan , China.
authors.forename: Xiu-Mei
authors.initials: XM
authors.lastname: Liu
authors.affiliation: a Department of Pathology , Shandong Provincial Hospital Affiliated to Shandong University , Jinan , China.
authors.forename: Ye-Jun
authors.initials: YJ
authors.lastname: Qin
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology*; D005260:Female; D005729:Ganglioneuroma / Q000175:diagnosis / Q000473:pathology*; D005784:Gene Amplification / Q000502:physiology; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D007223:Infant; D009447:Neuroblastoma / Q000175:diagnosis / Q000473:pathology*; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D016271:Proto-Oncogene Proteins c-myc
keywords: MYCN; Neuroblastoma; TrkA; ganglioneuroma