title: Oropharyngeal and laryngeal but not oral cancers are strongly associated with high-risk human papillomavirus in 172 Greek patients.
abstract: A strong and consistent association has been reported between human papillomavirus (HPV) infection and oropharyngeal cancer, whereas a similar link has not yet been clarified in oral and laryngeal cancer. The purpose of this study was to investigate the association between HPV infection and head and neck squamous cell carcinoma (HNSCC) in Greek patients. Cytological or tissue specimens from 172 cases patients with HNSCC and cytological specimens from 91 control subjects were analyzed for HPV DNA detection and genotyping using a microarray-based assay. Multivariate logistic regression was used to estimate odds ratios (ORs) for the association between the presence of HPV infection and HNSCC for each of the tumor site, after adjustment for potential confounders. The adjusted ORs for positivity to high-risk HPV infection for oropharyngeal and laryngeal cancer were 20.3 (95% CI: 1.7-250.1) and 22.8 (95% CI: 2.5-206.2), respectively. High-risk HPV infection was not significantly associated with oral cancer. HPV infection was independently associated with poorly differentiated tumors (OR = 2.8; 95% CI: 1.1-7.5). Our results suggest a strong association of high-risk HPV infection with oropharyngeal and laryngeal cancer. J. Med. Virol. 89:170-176, 2017. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Department of Virology, "St. Savvas" Regional Anticancer Oncology Hospital of Athens, Athens, Greece.
authors.forename: Elpida
authors.initials: E
authors.lastname: Tsimplaki
authors.affiliation: Department of Virology, "St. Savvas" Regional Anticancer Oncology Hospital of Athens, Athens, Greece.
authors.forename: Elena
authors.initials: E
authors.lastname: Argyri
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, "St. Savvas" Regional Anticancer Oncology Hospital of Athens, Athens, Greece.
authors.forename: Athanassios
authors.initials: A
authors.lastname: Sakellaridis
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, "Hippokration" General Hospital, National University of Athens, Athens, Greece.
authors.forename: Efthimios
authors.initials: E
authors.lastname: Kyrodimos
authors.affiliation: Department of Radiotherapy, "St. Savvas" Regional Anticancer Oncology Hospital of Athens, Athens, Greece.
authors.forename: Dimitra
authors.initials: D
authors.lastname: Xesfyngi
authors.affiliation: Department of Virology, "St. Savvas" Regional Anticancer Oncology Hospital of Athens, Athens, Greece. epanot@tee.gr.
authors.forename: Efstathia
authors.initials: E
authors.lastname: Panotopoulou
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000821:virology; D016022:Case-Control Studies; D004279:DNA, Viral / Q000032:analysis / Q000235:genetics; D005260:Female; D005838:Genotype; D006115:Greece / Q000453:epidemiology; D006801:Humans; D007822:Laryngeal Neoplasms / Q000453:epidemiology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000453:epidemiology* / Q000821:virology; D009959:Oropharyngeal Neoplasms / Q000453:epidemiology* / Q000821:virology; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000150:complications* / Q000821:virology; D018570:Risk Assessment; D055815:Young Adult
chemical_list: D004279:DNA, Viral
keywords: Greek patients; human papillomavirus; laryngeal cancer; oral cancer; oropharyngeal cancer