title: A case of septic arthritis caused by a Mycoplasma salivarium strain resistant towards Ciprofloxacin and Clarithromycin in a patient with chronic lymphatic leukemia.
abstract: Mycoplasma salivarium is a rare agent of septic arthritis in immunocompromised patients. We report a case of septic arthritis due to Mycoplasma salivarium in a patient with B-cell chronic lymphocytic leukemia who underwent chemotherapy with rituximab and bendamustin. Therapy of arthritis due to Mycoplasma salivarium is difficult because there are almost no susceptibility data available. The present case illustrates that antimicrobial susceptibility of Mycoplasma strains is not necessarily predictable and that antibiotic therapy should therefore be guided by in vitro susceptibility testing.
authors.affiliation: Institute of Medical Microbiology and Hygiene, University Medical Centre Freiburg, Hermann-Herder-Straße 11, 79104 Freiburg, Germany. Electronic address: martin.buechsel@uniklinik-freiburg.de.
authors.forename: Martin
authors.initials: M
authors.lastname: Büchsel
authors.affiliation: Department of Medical Oncology, Tumor Biology Center, Breisacher Straße 117, 79106 Freiburg, Germany.
authors.forename: Lars
authors.initials: L
authors.lastname: Pletschen
authors.affiliation: Department of Medical Oncology, Tumor Biology Center, Breisacher Straße 117, 79106 Freiburg, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Fleiner
authors.affiliation: Institute of Medical Microbiology and Hygiene, University Medical Centre Freiburg, Hermann-Herder-Straße 11, 79104 Freiburg, Germany.
authors.forename: Georg
authors.initials: G
authors.lastname: Häcker
authors.affiliation: Institute of Medical Microbiology and Hygiene, University Medical Centre Freiburg, Hermann-Herder-Straße 11, 79104 Freiburg, Germany.
authors.forename: Annerose
authors.initials: A
authors.lastname: Serr
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001170:Arthritis, Infectious / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology; D000069461:Bendamustine Hydrochloride / Q000627:therapeutic use; D002939:Ciprofloxacin / Q000494:pharmacology*; D017291:Clarithromycin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications / Q000188:drug therapy; D008297:Male; D009175:Mycoplasma Infections / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology; D045804:Mycoplasma salivarium / Q000187:drug effects* / Q000302:isolation & purification; D000069283:Rituximab / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D000069283:Rituximab; D002939:Ciprofloxacin; D000069461:Bendamustine Hydrochloride; D017291:Clarithromycin
keywords: B-CLL; Mycoplasma salivarium; Rituximab; Septic arthritis; Susceptibility