title: Quinoxaline Nucleus: A Promising Scaffold in Anti-cancer Drug Discovery.
abstract: Heterocyclic compounds are a class of substances, which play a critical role in modern drug discovery being incorporated in the structure of a large variety of drugs used in many different types of diseases. Quinoxaline is an important heterocyclic nucleus with a wide spectrum of biological activities, and recently much attention has been found on anticancer drug discovery based on this class. Owing to the importance of this system, the aim of this review is to provide an update on the synthesis and anticancer activity of quinoxaline derivatives covering articles published between 2010 and 2015.
authors.forename: Alessandra C
authors.initials: AC
authors.lastname: Pinheiro
authors.forename: Thais C
authors.initials: TC
authors.lastname: Mendonça Nogueira
authors.affiliation: FioCruz-Fundação Oswaldo Cruz, Instituto de Tecnologia em Fármacos-Far-Manguinhos, Rua Sizenando Nabuco, 100, Manguinhos, 21041-250, Rio de Janeiro - RJ, Brazil. marcos_souza@far.fiocruz.br.
authors.forename: Marcus V N
authors.initials: MV
authors.lastname: de Souza
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D060326:Chemistry Techniques, Synthetic; D055808:Drug Discovery; D006801:Humans; D011810:Quinoxalines / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D011810:Quinoxalines