title: Schiff Base-Poloxamer P85 Combination Prevents Prostate Cancer Progression in C57/Bl6 Mice.
abstract: Prostate cancer which is the second most common cause of death among men has a high incidence in recent years. Current therapeutic regimens should be improved to overcome drug resistance. At the metastatic stage, tumors become refractory to established chemotherapeutic treatments and cause serious problems at the clinics. Development of new drug molecules that are able to transport through the membrane easily and kill tumor cells rapidly is of great interest.
  
  
  
  In the current study, a novel Heterodinuclear copper(II)Mn(II) Schiff base complex combined with P85 was used for prostate cancer treatment in vivo. Tramp-C1 cells injected animals were subjected to chemotherapeutic formulation treatment and results were analyzed by toxicology analysis, tumor volume measurements, and histopathological analysis. 0.5 mg/kg Schiff base was selected and combined with 0.05% P85 according to the toxicology analysis showing the enzyme levels, blood parameters, and multiple organ toxicity.
  
  
  
  Results demonstrated that Heterodinuclear copper(II)Mn(II) complex-P85 combination decreased tumor formation and tumor volume steadily over the course of experiments.
  
  
  
  Overall, Heterodinuclear copper(II)Mn(II) complex-P85 exerted remarkable anti-cancer activity in vivo in C57/B16 mice. Prostate 76:1454-1463, 2016. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Faculty of Engineering and Architecture, Department of Genetics and Bioengineering, Yeditepe University, Istanbul, Turkey. aguldgn@gmail.com.
authors.forename: Ayşegül
authors.initials: A
authors.lastname: Doğan
authors.affiliation: Faculty of Engineering and Architecture, Department of Genetics and Bioengineering, Yeditepe University, Istanbul, Turkey.
authors.forename: Selami
authors.initials: S
authors.lastname: Demirci
authors.affiliation: Department of Pharmaceutical Toxicology, Inonu University, Malatya, Turkey.
authors.forename: Neşe Başak
authors.initials: NB
authors.lastname: Türkmen
authors.affiliation: Faculty of Medicine, Department of Physiology, Istanbul Medipol University, Istanbul, Turkey.
authors.forename: Ahmet Burak
authors.initials: AB
authors.lastname: Çağlayan
authors.affiliation: Faculty of Engineering and Architecture, Department of Genetics and Bioengineering, Yeditepe University, Istanbul, Turkey.
authors.forename: Safa
authors.initials: S
authors.lastname: Aydın
authors.affiliation: Faculty of Engineering and Architecture, Department of Genetics and Bioengineering, Yeditepe University, Istanbul, Turkey.
authors.forename: Dilek
authors.initials: D
authors.lastname: Telci
authors.affiliation: Faculty of Medicine, Department of Physiology, Istanbul Medipol University, Istanbul, Turkey.
authors.forename: Ertuğrul
authors.initials: E
authors.lastname: Kılıç
authors.affiliation: Faculty of Veterinary Medicine, Department of Animal Nutrition, Fırat University, Elazığ, Turkey.
authors.forename: Kazım
authors.initials: K
authors.lastname: Şahin
authors.affiliation: Faculty of Veterinary Medicine, Department of Animal Nutrition, Fırat University, Elazığ, Turkey.
authors.forename: Cemal
authors.initials: C
authors.lastname: Orhan
authors.affiliation: Faculty of Science, Department of Biology, Fırat University, Elazığ, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Tuzcu
authors.affiliation: Faculty of Medicine, Department of Pathology, Yeditepe University, Istanbul, Turkey.
authors.forename: Asiye Işın Doğan
authors.initials: AI
authors.lastname: Ekici
authors.affiliation: Faculty of Engineering and Architecture, Department of Genetics and Bioengineering, Yeditepe University, Istanbul, Turkey.
authors.forename: Fikrettin
authors.initials: F
authors.lastname: Şahin
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000517:prevention & control*; D000818:Animals; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D018450:Disease Progression; D004338:Drug Combinations; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D020442:Poloxamer / Q000008:administration & dosage* / Q000633:toxicity; D011471:Prostatic Neoplasms / Q000473:pathology / Q000517:prevention & control*; D012545:Schiff Bases / Q000008:administration & dosage* / Q000633:toxicity; D047368:Tumor Burden
chemical_list: D004338:Drug Combinations; D012545:Schiff Bases; D020442:Poloxamer
keywords: P85; Schiff base; pluronic; prostate cancer; tramp-C1