title: Simulated Bench Testing to Evaluate the Mechanical Performance of New Carotid Stents.
abstract: Our group recently developed a novel covered carotid stent that can prevent emboli while preserving the external carotid artery (ECA) branch blood flow. However, our recent in vitro side-branch ECA flow preservation tests on the covered stents revealed the need for further stent frame design improvements, including the consideration to crimp the stent to a low profile for the delivery of the stent system and having bigger cells. Hence, the current work aims to design new bare metal stents with bigger cell size to improve the crimpability and to accommodate more slits so that the side-branch flow could be further increased. Three new stent designs were analyzed using finite element analysis and benchmarked against two commercially available carotid stents in terms of their mechanical performances such as crimpability, radial strength, and flexibility. Results indicated that the new bare metal stent designs matched well against the commercial stents. Hence our new generation covered stents based on these designs can be expected to perform better in side-branch flow preservation without compromising on their mechanical performances.
authors.affiliation: Institute of High Performance Computing, A*STAR.
authors.forename: Gideon Praveen
authors.initials: GP
authors.lastname: Kumar
authors.affiliation: Department of Bioengineering, National University of Singapore.|Department of Surgery, National University of Singapore.
authors.forename: Foad
authors.identifier: http://orcid.org/0000-0002-4125-5064
authors.initials: F
authors.lastname: Kabinejadian
authors.affiliation: Institute of High Performance Computing, A*STAR.
authors.forename: Jianfei
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Surgery, National University of Singapore.|Department of Cardiac, Thoracic & Vascular Surgery, National University Health System, Singapore.
authors.forename: Pei
authors.initials: P
authors.lastname: Ho
authors.affiliation: Department of Bioengineering, National University of Singapore.
authors.forename: Hwa Liang
authors.initials: HL
authors.lastname: Leo
authors.affiliation: Institute of High Performance Computing, A*STAR.
authors.forename: Fangsen
authors.initials: F
authors.lastname: Cui
mesh_terms: D000497:Alloys; D017130:Angioplasty / Q000295:instrumentation*; D001783:Blood Flow Velocity; D002340:Carotid Artery Diseases / Q000503:physiopathology / Q000628:therapy*; D003198:Computer Simulation; D017076:Computer-Aided Design; D020342:Finite Element Analysis; D008422:Materials Testing; D008955:Models, Cardiovascular; D011474:Prosthesis Design / Q000379:methods*; D011475:Prosthesis Failure; D012039:Regional Blood Flow; D015607:Stents; D013314:Stress, Mechanical
chemical_list: D000497:Alloys; C013616:nitinol
keywords: Carotid artery stenting; Computer aided design; Crimpability; Finite element analysis; Nitinol; Self-expandable stents; Stent design