title: Associations between gene polymorphisms of the apelin-APJ system and the risk of hypertension.
abstract: The aim of this study was to assess the associations between single nucleotide polymorphisms (SNPs) of the apelin and APJ (apelin receptor) genes and the risk of hypertension in people living in the south-east coastal area of China. A cross-sectional study involving 1031 participants was performed. Genotypes of the apelin (rs3115757, rs56204867 and rs3761581) and APJ (rs7119375 and rs9943582) genes were determined by the TaqMan® MGB probe method. For male patients, the frequencies of mutant alleles in the three apelin gene SNPs were significantly different between the hypertension and control groups (all p < 0.05), while no significant difference was obtained for frequencies of mutant alleles in the two APJ gene SNPs (p > 0.05). For females, the frequencies of mutant alleles in all five SNPs were not significantly different between the hypertension and control groups (all p > 0.05). After adjusting for several factors, the risk of developing hypertension increased significantly in patients, regardless of gender, carrying rs3115757-C, rs56204867-C or rs3761581-A allele (all p < 0.05). The optimal gene-gene interaction model for both males and females with regard to hypertension was apelin rs3761581-apelin rs3115757-APJ rs7119375. In conclusion, gene polymorphisms of the apelin-APJ system are associated with susceptibility to hypertension.
authors.affiliation: a Department of Geriatric Medicine , Fujian Provincial Hospital, Fujian Institute of Clinical Geriatrics, Fujian Medical University , Fuzhou , PR China.
authors.forename: Feng
authors.initials: F
authors.lastname: Huang
authors.affiliation: a Department of Geriatric Medicine , Fujian Provincial Hospital, Fujian Institute of Clinical Geriatrics, Fujian Medical University , Fuzhou , PR China.
authors.forename: Pengli
authors.initials: P
authors.lastname: Zhu
authors.affiliation: a Department of Geriatric Medicine , Fujian Provincial Hospital, Fujian Institute of Clinical Geriatrics, Fujian Medical University , Fuzhou , PR China.
authors.forename: Qiuxia
authors.initials: Q
authors.lastname: Huang
authors.affiliation: a Department of Geriatric Medicine , Fujian Provincial Hospital, Fujian Institute of Clinical Geriatrics, Fujian Medical University , Fuzhou , PR China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: a Department of Geriatric Medicine , Fujian Provincial Hospital, Fujian Institute of Clinical Geriatrics, Fujian Medical University , Fuzhou , PR China.
authors.forename: Fan
authors.initials: F
authors.lastname: Lin
authors.affiliation: a Department of Geriatric Medicine , Fujian Provincial Hospital, Fujian Institute of Clinical Geriatrics, Fujian Medical University , Fuzhou , PR China.
authors.forename: Qiaowei
authors.initials: Q
authors.lastname: Li
mesh_terms: D000328:Adult; D000483:Alleles; D000073861:Apelin; D000075244:Apelin Receptors; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000453:epidemiology* / Q000235:genetics*; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D043562:Receptors, G-Protein-Coupled / Q000235:genetics*; D012307:Risk Factors
chemical_list: C115436:APLN protein, human; C104575:APLNR protein, human; D000073861:Apelin; D000075244:Apelin Receptors; D036341:Intercellular Signaling Peptides and Proteins; D043562:Receptors, G-Protein-Coupled
keywords: Apelin–APJ system; primary hypertension; single nucleotide polymorphism