title: [Constipation and cancer: Current strategies].
abstract: Digestive disorders, in particular constipation, are symptoms very often reported by cancer patients as having a major impact on their quality of life. An accurate diagnosis of bowel delayed transit and defecation disorders is required to best adapt therapeutic management. Constipation associated with cancer may be related to several causes, which can be placed in three nosological categories that sometimes overlap: chronic constipation prior to cancer and having its own evolution; constipation related to the cancer condition, in particular the occlusive syndrome, and constipation induced by cancer therapies. The stricter application of diet and lifestyle measures is often necessary and sometimes sufficient. Laxative drug treatments come under various galenic forms and administration routes and must be selected according to the clinical features of constipation. Surgical management can be indicated in case of ileus or pelvic static disorders. In the case of refractory constipation induced by opioids and within the framework of palliative care to treat an advanced pathology, a peripheral morphinic antagonist can offer fast symptom relief. A way forward to improve the patients' quality of life could be to identify the contributing factors (in particular, genetic factors) to determine which patients are the more at risk and anticipate their management.
authors.affiliation: AP-HP, hôpital européen Georges-Pompidou, service d'oncologie médicale-unité fonctionnelle de soins de support, 20, rue Leblanc, 75015 Paris, France. Electronic address: claire.gervais@yahoo.fr.
authors.forename: Claire
authors.initials: C
authors.lastname: Gervais
authors.affiliation: CHU de Rouen, Inserm UMR 1073, hôpital Charles-Nicolle, service d'hépato-gastro-entérologie et nutrition, 1, rue de Germont, 76031 Rouen cedex, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Ducrotté
authors.affiliation: CHU de Nice, EA Inserm 6302, hôpital de l'Archet 2, service de gastro-entérologie et oncologie digestive, 151, route St-Antoine-de-Ginestière, CS 23079, 06202 Nice cedex 3, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Piche
authors.affiliation: Unicancer, Institut Gustave-Roussy, département ambulatoire, 114, rue Edouard-Vaillant, 94800 Villejuif cedex, France.
authors.forename: Mario
authors.initials: M
authors.lastname: Di Palma
authors.affiliation: Unicancer, Institut Jean-Godinot, département d'oncologie médicale, 1, avenue du Général-Koenig, CS 80014, 51726 Reims cedex, France; Centre hospitalier de Saint-Dizier, cancérologie transversale, 1, rue Albert-Schweitzer, CS 10001, 52115 Saint-Dizier cedex, France; Clinique François I(er), service d'oncologie médicale, 12, rue François I(er), 52122 Saint-Dizier, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Jovenin
authors.affiliation: AP-HP, hôpital européen Georges-Pompidou, service d'oncologie médicale-unité fonctionnelle de soins de support, 20, rue Leblanc, 75015 Paris, France.
authors.forename: Florian
authors.initials: F
authors.lastname: Scotté
mesh_terms: D000367:Age Factors; D000701:Analgesics, Opioid / Q000009:adverse effects; D002908:Chronic Disease; D003125:Colostomy; D003248:Constipation / Q000145:classification / Q000209:etiology* / Q000628:therapy; D006801:Humans; D009369:Neoplasms / Q000150:complications*; D011788:Quality of Life; D012307:Risk Factors
chemical_list: D000701:Analgesics, Opioid
keywords: Cancer; Constipation; Laxatif; Laxative; Opioid; Opioïde; Quality of life; Qualité de vie; Soins de support; Supportive care