title: Anti-erosive effects of fluoride and phytosphingosine: an in vitro study.
abstract: A selection of commercially available products containing stannous fluoride (SnF2 )/sodium fluoride (NaF), SnF2 /amorphous calcium phosphate (ACP), SnF2 /NaF/ACP, tin (Sn)/fluorine (F)/chitosan were compared with phytosphingosine (PHS) with respect to their anti-erosive properties in vitro. One-hundred and twenty bovine enamel specimens were immersed in the respective product slurries for 2 min, twice daily. The formulations were diluted with either remineralization solution or artificial saliva. After each treatment, an erosive challenge was performed for 10 min, twice daily, using citric acid, pH 3.4. The specimens were stored in remineralization solution or artificial saliva until the next treatment-erosion challenge. After 10 d, tissue loss was determined using profilometry. Enamel softening was determined through surface microhardness measurements. Tissue-loss values (measured in μm and expressed as mean ± SD) for PHS, SnF2 /NaF, SnF2 /ACP, SnF2 /ACP/NaF, and Sn/F/chitosan treatment groups and for the negative-control group, were, respectively, 35.6 ± 2.8, 15.8 ± 1.8, 22.1 ± 2.0, 22.9 ± 1.8, 16.2 ± 1.2, and 51.2 ± 4.4 in the presence of remineralization solution and 31.7 ± 3.3, 15.6 ± 2.9, 16.5 ± 2.7, 16.8 ± 2.1, 13.1 ± 3.0, and 50.7 ± 2.8 in the presence of artificial saliva. There were no significant differences in surface microhardness measurements between the treatment groups. In conclusion, PHS resulted in a significant reduction of tissue loss compared with the negative control, but in comparison, the toothpastes containing Sn(2+) and F(-) ions were significantly more effective compared with PHS.
authors.affiliation: Department of Paediatric Dentistry, Faculty of Dentistry, Near East University, Nicosia, Cyprus.|Department of Cariology Endodontology Pedodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University, Amsterdam, the Netherlands.
authors.forename: Nermin
authors.initials: N
authors.lastname: Yönel
authors.affiliation: Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University, Amsterdam, the Netherlands.
authors.forename: Floris J
authors.initials: FJ
authors.lastname: Bikker
authors.affiliation: Department of Cariology Endodontology Pedodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University, Amsterdam, the Netherlands.
authors.forename: Maxim D
authors.initials: MD
authors.lastname: Lagerweij
authors.affiliation: Department of Dental Materials Science, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University, Amsterdam, the Netherlands.
authors.forename: Cees J
authors.initials: CJ
authors.lastname: Kleverlaan
authors.affiliation: Department of Cariology Endodontology Pedodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University, Amsterdam, the Netherlands.
authors.forename: Cor
authors.initials: C
authors.lastname: van Loveren
authors.affiliation: Department of Cariology Endodontology Pedodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University, Amsterdam, the Netherlands.
authors.forename: Bugra
authors.initials: B
authors.lastname: Özen
authors.affiliation: Department of Paediatric Dentistry, Faculty of Dentistry, Near East University, Nicosia, Cyprus.
authors.forename: Serap
authors.initials: S
authors.lastname: Çetiner
authors.affiliation: Department of Cariology Endodontology Pedodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University, Amsterdam, the Netherlands.
authors.forename: Augustinus J P
authors.initials: AJ
authors.lastname: van Strijp
mesh_terms: D000818:Animals; D002327:Cariostatic Agents / Q000494:pharmacology*; D002417:Cattle; D005459:Fluorides / Q000494:pharmacology*; D012969:Sodium Fluoride; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D014002:Tin Fluorides; D014077:Tooth Erosion; D014089:Tooth Remineralization; D014100:Toothpastes
chemical_list: D002327:Cariostatic Agents; D014002:Tin Fluorides; D014100:Toothpastes; D012969:Sodium Fluoride; C012491:phytosphingosine; D013110:Sphingosine; D005459:Fluorides
keywords: chitosan; erosion; fluoride; phytosphingosine; toothpaste