title: Brain activation differences in schizophrenia during context-dependent processing of saccade tasks.
abstract: BACKGROUND
  Brain function in schizophrenia has been probed using saccade paradigms and functional magnetic resonance imaging, but little information exists about how changing task context impacts saccade related brain activation and behavioral performance. We recruited schizophrenia and comparison subjects to perform saccade tasks in differing contexts: (1) two single task runs (anti- or pro-saccades alternating with fixation) and (2) one dual task run (antisaccades alternating with prosaccades).
  
  
  RESULTS
  Context-dependent differences in saccade circuitry were evaluated using ROI analyses. Distinction between anti- and pro-saccade activation across contexts (single versus dual task) suggests that the schizophrenia group did not respond to context in the same way as the comparison group.
  
  
  CONCLUSIONS
  Further investigation of context processing effects on brain activation and saccade performance measures informs models of cognitive deficits in the disorder and enhances understanding of antisaccades as a potential endophenotype for schizophrenia.
authors.affiliation: Department of Psychology, University of Georgia, Psychology Building 125 Baldwin Street, Athens, GA, 30602, USA.
authors.forename: A L
authors.initials: AL
authors.lastname: Rodrigue
authors.affiliation: Department of Psychology, University of Georgia, Psychology Building 125 Baldwin Street, Athens, GA, 30602, USA.|Department of Medicine, School of Medicine and Public Health, University of Wisconsin, 2500 Overlook Terrace, Madison, WI, 53705, USA.
authors.forename: B P
authors.initials: BP
authors.lastname: Austin
authors.affiliation: Department of Psychology, University of Georgia, Psychology Building 125 Baldwin Street, Athens, GA, 30602, USA.
authors.forename: K A
authors.initials: KA
authors.lastname: Dyckman
authors.affiliation: Department of Psychology, University of Georgia, Psychology Building 125 Baldwin Street, Athens, GA, 30602, USA. jemcd@uga.edu.
authors.forename: J E
authors.initials: JE
authors.lastname: McDowell
mesh_terms: D000328:Adult; D001921:Brain / Q000378:metabolism / Q000503:physiopathology*; D001931:Brain Mapping; D005133:Eye Movements / Q000502:physiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010775:Photic Stimulation; D011930:Reaction Time / Q000502:physiology; D012438:Saccades / Q000502:physiology; D012559:Schizophrenia / Q000378:metabolism / Q000503:physiopathology*
keywords: Antisaccades; Context; Prosaccades; Schizophrenia; fMRI