title: Hemostatic assessment of dogs associated with hepatic parasite load of Leishmania infantum chagasi.
abstract: Leishmania infantum chagasi liver parasite load was compared to hemostatic abnormalities, as well as to clinical, laboratorial, and histopathological findings in dogs with visceral leishmaniasis. The liver parasite load of 30 dogs L. infantum chagasi naturally-infected was evaluated by quantitative real- time PCR and the results were compared with serum biochemistry and primary and secondary hemostasis findings. Moreover, hepatic histological lesions were described in these dogs. Prolonged bleeding time, prothrombin time (PT), and activated partial thromboplastin time (APTT), were observed in the group with visceral leishmaniasis. Eleven dogs presented inflammatory liver lesions, with predominance of mild multifocal mononuclear periportal hepatitis. No association between the presence of parasites and abnormalities in screening tests was observed by Spearman's rank correlation coefficient. The clinical progression in leishmaniasis is associated with the occurrence of hemorrhagic diathesis, which depends not only on the presence of the parasite but also the inflammatory process, compromised immunological response, hepatic and renal failure in symptomatic dogs.
authors.affiliation: Departamento de Clínica Médica Veterinária, Universidade Federal de Mato Grosso, Universidade Federal de Mato Grosso, Cuiabá MT , Brasil, Departamento de Clínica Médica Veterinária, Universidade Federal de Mato Grosso - UFMT, Cuiabá, MT, Brasil.
authors.forename: Mariana de Medeiros
authors.initials: Mde M
authors.lastname: Torres
authors.affiliation: Departamento de Clínica Médica Veterinária, Universidade Federal de Mato Grosso, Universidade Federal de Mato Grosso, Cuiabá MT , Brasil, Departamento de Clínica Médica Veterinária, Universidade Federal de Mato Grosso - UFMT, Cuiabá, MT, Brasil.
authors.forename: Arleana do Bom Parto Ferreira de
authors.initials: Ado B
authors.lastname: Almeida
authors.affiliation: Departamento de Clínica Médica Veterinária, Universidade Federal de Mato Grosso, Universidade Federal de Mato Grosso, Cuiabá MT , Brasil, Departamento de Clínica Médica Veterinária, Universidade Federal de Mato Grosso - UFMT, Cuiabá, MT, Brasil.
authors.forename: Daphine Ariadne Jesus de
authors.initials: DA
authors.lastname: Paula
authors.affiliation: Departamento de Clínica Médica Veterinária, Universidade Federal de Mato Grosso, Universidade Federal de Mato Grosso, Cuiabá MT , Brasil, Departamento de Clínica Médica Veterinária, Universidade Federal de Mato Grosso - UFMT, Cuiabá, MT, Brasil.
authors.forename: Adriane Jorge
authors.initials: AJ
authors.lastname: Mendonça
authors.affiliation: Departamento de Clínica Médica Veterinária, Universidade Federal de Mato Grosso, Universidade Federal de Mato Grosso, Cuiabá MT , Brasil, Departamento de Clínica Médica Veterinária, Universidade Federal de Mato Grosso - UFMT, Cuiabá, MT, Brasil.
authors.forename: Luciano
authors.initials: L
authors.lastname: Nakazato
authors.affiliation: Departamento de Clínica Médica Veterinária, Universidade Federal de Mato Grosso, Universidade Federal de Mato Grosso, Cuiabá MT , Brasil, Departamento de Clínica Médica Veterinária, Universidade Federal de Mato Grosso - UFMT, Cuiabá, MT, Brasil.
authors.forename: Caroline Argenta
authors.initials: CA
authors.lastname: Pescador
authors.affiliation: Departamento de Clínica Médica Veterinária, Universidade Federal de Mato Grosso, Universidade Federal de Mato Grosso, Cuiabá MT , Brasil, Departamento de Clínica Médica Veterinária, Universidade Federal de Mato Grosso - UFMT, Cuiabá, MT, Brasil.
authors.forename: Valéria Régia Franco
authors.initials: VR
authors.lastname: Sousa
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D006487:Hemostasis; D018314:Leishmania infantum; D007898:Leishmaniasis, Visceral / Q000097:blood / Q000662:veterinary*; D059208:Parasite Load / Q000662:veterinary*