title: Metabolizable Ultrathin Bi2 Se3 Nanosheets in Imaging-Guided Photothermal Therapy.
abstract: Poly(vinylpyrrolidone)-encapsulated Bi2 Se3 nanosheets with a thickness of 1.7 nm and diameter of 31.4 nm are prepared by a solution method. Possessing an extinction coefficient of 11.5 L g(-1) cm(-1) at 808 nm, the ultrathin Bi2 Se3 nanosheets boast a high photothermal conversion efficiency of 34.6% and excellent photoacoustic performance. After systemic administration, the Bi2 Se3 nanosheets with the proper size and surface properties accumulate passively in tumors enabling efficient photoacoustic imaging of the entire tumors to facilitate photothermal cancer therapy. In vivo biodistribution studies reveal that they are expelled from the body efficiently after 30 d. The ultrathin Bi2 Se3 nanosheets have large clinical potential as metabolizable near-infrared-triggered theranostic agents.
authors.affiliation: Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China.|Department of Physics, Wuhan University, Wuhan, 430072, P. R. China.
authors.forename: Hanhan
authors.initials: H
authors.lastname: Xie
authors.affiliation: Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China.
authors.forename: Zhibin
authors.initials: Z
authors.lastname: Li
authors.affiliation: SZU-NUS Collaborative Innovation Center for Optoelectronic Science and Technology, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, P. R. China.
authors.forename: Zhengbo
authors.initials: Z
authors.lastname: Sun
authors.affiliation: SZU-NUS Collaborative Innovation Center for Optoelectronic Science and Technology, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, P. R. China.
authors.forename: Jundong
authors.initials: J
authors.lastname: Shao
authors.affiliation: Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China.
authors.forename: Xue-Feng
authors.initials: XF
authors.lastname: Yu
authors.affiliation: SZU-NUS Collaborative Innovation Center for Optoelectronic Science and Technology, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, P. R. China.
authors.forename: Zhinan
authors.initials: Z
authors.lastname: Guo
authors.affiliation: Department of Physics, Wuhan University, Wuhan, 430072, P. R. China.
authors.forename: Jiahong
authors.initials: J
authors.lastname: Wang
authors.affiliation: SZU-NUS Collaborative Innovation Center for Optoelectronic Science and Technology, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, P. R. China.
authors.forename: Quanlan
authors.initials: Q
authors.lastname: Xiao
authors.affiliation: Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China.|Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, 999077, China.
authors.forename: Huaiyu
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Physics, Wuhan University, Wuhan, 430072, P. R. China.
authors.forename: Qu-Quan
authors.initials: QQ
authors.lastname: Wang
authors.affiliation: SZU-NUS Collaborative Innovation Center for Optoelectronic Science and Technology, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, P. R. China.
authors.forename: Han
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, 999077, China.
authors.forename: Paul K
authors.initials: PK
authors.lastname: Chu
mesh_terms: D000818:Animals; D006801:Humans; D006979:Hyperthermia, Induced; D053758:Nanoparticles / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry; D010789:Phototherapy / Q000379:methods*; D000068936:Theranostic Nanomedicine / Q000379:methods
keywords: 2D layered materials; Bi2Se3 nanosheets; photoacoustic imaging; photothermal therapy; theranostics