title: Left Prefrontal Repetitive Transcranial Magnetic Stimulation in a Logopenic Variant of Primary Progressive Aphasia: A Case Report.
abstract: High frequency repetitive transcranial magnetic stimulation (hf-rTMS) improves language skills in Alzheimer's disease (AD). We report the use of hf-rTMS in a patient with logopenic primary progressive aphasia (LPPA) due to AD.
  
  
  
  hf-rTMS was applied to the left dorsolateral prefrontal cortex of a LPPA patient. Cerebral perfusion, neuropsychological and linguistic performances were evaluated before and 1 month after hf-rTMS.
  
  
  
  The tolerance was good. Improvements on linguistic (fluency, naming, lesser paraphasia) and cognitive skills (Mini Mental State Examination, verbal memory free recall, speed processing) and cerebral perfusion were observed.
  
  
  
  hf-rTMS can be used in LPPA patients. A procognitive effect persisting several weeks after stimulation in LPPA patients was suggested and should therefore be evaluated in a clinical trial as an adjunctive therapeutic tool.
authors.affiliation: Department of Memory Center of Research and Resources (CMRR), University Hospital of Besanx00E7;on, Besanx00E7;on, France.
authors.forename: Matthieu
authors.initials: M
authors.lastname: Bereau
authors.forename: Eloi
authors.initials: E
authors.lastname: Magnin
authors.forename: Magali
authors.initials: M
authors.lastname: Nicolier
authors.forename: Louis
authors.initials: L
authors.lastname: Berthet
authors.forename: Elfried
authors.initials: E
authors.lastname: Dariel
authors.forename: Sabrina
authors.initials: S
authors.lastname: Ferreira
authors.forename: Géraldine
authors.initials: G
authors.lastname: Sylvestre
authors.forename: Julie
authors.initials: J
authors.lastname: Monnin
authors.forename: Gilles
authors.initials: G
authors.lastname: Chopard
authors.forename: Hatem
authors.initials: H
authors.lastname: Bouladour
authors.forename: Pierre
authors.initials: P
authors.lastname: Vandel
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Haffen
mesh_terms: D000368:Aged; D018888:Aphasia, Primary Progressive / Q000175:diagnosis / Q000628:therapy*; D003071:Cognition / Q000502:physiology; D005260:Female; D006801:Humans; D009483:Neuropsychological Tests; D050781:Transcranial Magnetic Stimulation / Q000379:methods*; D016896:Treatment Outcome