title: Bacterial Metabolism Shapes the Host-Pathogen Interface.
abstract: Bacterial pathogens have evolved to exploit humans as a rich source of nutrients to support survival and replication. The pathways of bacterial metabolism that permit successful colonization are surprisingly varied and highlight remarkable metabolic flexibility. The constraints and immune pressures of distinct niches within the human body set the stage for understanding the mechanisms by which bacteria acquire critical nutrients. In this article we discuss how different bacterial pathogens carry out carbon and energy metabolism in the host and how they obtain or use key nutrients for replication and immune evasion.
authors.affiliation: Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109.
authors.forename: Karla D
authors.initials: KD
authors.lastname: Passalacqua
authors.affiliation: Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109.
authors.forename: Marie-Eve
authors.initials: ME
authors.lastname: Charbonneau
authors.affiliation: Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109.
authors.forename: Mary X D
authors.initials: MXD
authors.lastname: O'Riordan
mesh_terms: D000818:Animals; D001419:Bacteria / Q000254:growth & development / Q000378:metabolism* / Q000472:pathogenicity*; D002244:Carbon / Q000378:metabolism; D004734:Energy Metabolism; D054884:Host-Pathogen Interactions; D006801:Humans; D057131:Immune Evasion; D053858:Metabolic Networks and Pathways; D014774:Virulence
chemical_list: D002244:Carbon