title: [Disease burden of liver cancer in the Chinese population, in 1990 and 2013].
abstract: OBJECTIVE
  To analyze the disease burden of liver cancer in the Chinese population in 1990 and 2013.
  
  
  METHODS
  Data from Global Burden of Diseases 2013 (GBD2013) was used to analyze the disease burden of liver cancer in China. The main outcome measurements would include mortality and disability-adjusted life years (DALY). Again, GBD global standard population in 2013 was used as the reference population to calculate the age-standardized rate. Related changes on percentage from 1990 to 2013 were calculated to analyze the changing patterns of disease burden for liver cancer in China.
  
  
  RESULTS
  In 2013, a total of 358 100 people died of liver cancer, with the crude death rate as 25.85/100 000, in China. Number of deaths due to liver cancer secondary to hepatitis B was 163 600 (accounting for 45.69%). Number of deaths due to liver cancer secondary to hepatitis C was 134 200 (accounting for 37.48%) with DALY due to liver cancer appeared as 40.80 million person years. In 2013, the leading causes of DALY related to liver cancer was liver cancer secondary to hepatitis B, followed by liver cancer secondary to hepatitis C, liver cancer secondary to alcohol use, other liver cancers, with related DALYs as 4 652.0, 3 394.3, 964.3 and 592.1 thousands person years, respectively. The disease burdens of liver cancer secondary to various kinds of liver cancer were significantly higher in males than in females. Compared with 1990, the standardized mortality of liver cancer reduced by 25.00%, the DALY attributable to liver cancer increased by 16.95% and the standardized DALY rate attributable to liver cancer reduced by 33.47%. The burden of liver cancer secondary to hepatitis C became more serious and the standardized death rate increased by 106.18%, together with the standardized DALY rate increased by 91.68% in the past 23 years. Disease burden of liver cancer among young adults and the elderly were most serious. When comparing with the data in 1990, the standardized DALY rate showed declining trend in all the age groups, with the most seen in the 5-14 year group. The standardized DALY rate, secondary to hepatitis B had a 46.37% decrease in the 5-14 year olds. The standardized DALY rate secondary to hepatitis C showed an increasing trend in all the age groups.
  
  
  CONCLUSIONS
  Liver cancer had been one of the serious diseases that causing heavy disease burden in China. In recent years, the disease burden of liver cancer secondary to hepatitis B decreased but the disease burden of liver cancer secondary to hepatitis C significantly increased. Disease burden on liver cancer in male population was significantly higher than that in females, showing that related targeted prevention and control measures should be imminently carried out.
authors.affiliation: Division of Vital Statistics and Death Surveillance, National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
authors.forename: L J
authors.initials: LJ
authors.lastname: Wang
authors.affiliation: Division of Vital Statistics and Death Surveillance, National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
authors.forename: P
authors.initials: P
authors.lastname: Yin
authors.affiliation: Division of Vital Statistics and Death Surveillance, National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
authors.forename: Y N
authors.initials: YN
authors.lastname: Liu
authors.affiliation: Division of Vital Statistics and Death Surveillance, National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
authors.forename: J M
authors.initials: JM
authors.lastname: Liu
authors.affiliation: Division of Vital Statistics and Death Surveillance, National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
authors.forename: J L
authors.initials: JL
authors.lastname: Qi
authors.affiliation: National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
authors.forename: M G
authors.initials: MG
authors.lastname: Zhou
mesh_terms: D000428:Alcohol Drinking; D044466:Asian People; D002681:China; D005260:Female; D006801:Humans; D008113:Liver Neoplasms; D008297:Male; D017063:Outcome Assessment, Health Care; D019057:Quality-Adjusted Life Years; D047368:Tumor Burden