title: Next Generation Mesenchymal Stem Cell (MSC)-Based Cartilage Repair Using Scaffold-Free Tissue Engineered Constructs Generated with Synovial Mesenchymal Stem Cells.
abstract: Because of its limited healing capacity, treatments for articular cartilage injuries are still challenging. Since the first report by Brittberg, autologous chondrocyte implantation has been extensively studied. Recently, as an alternative for chondrocyte-based therapy, mesenchymal stem cell-based therapy has received considerable research attention because of the relative ease in handling for tissue harvest, and subsequent cell expansion and differentiation. This review summarizes latest development of stem cell therapies in cartilage repair with special attention to scaffold-free approaches.
authors.affiliation: Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Kazunori
authors.initials: K
authors.lastname: Shimomura
authors.affiliation: Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Wataru
authors.initials: W
authors.lastname: Ando
authors.affiliation: Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Yu
authors.initials: Y
authors.lastname: Moriguchi
authors.affiliation: Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Norihiko
authors.initials: N
authors.lastname: Sugita
authors.affiliation: Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Yasui
authors.affiliation: Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Kota
authors.initials: K
authors.lastname: Koizumi
authors.affiliation: Biomechanics Laboratory, Department of Mechanical Engineering, Kogakuin University, Tokyo, Japan; Division of Human Mechatronics Systems, Faculty of System Design, Tokyo Metropolitan University, Tokyo, Japan.
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Fujie
authors.affiliation: McCaig Institute for Bone & Joint Health, University of Calgary, Calgary, Alberta, Canada.
authors.forename: David A
authors.initials: DA
authors.lastname: Hart
authors.affiliation: Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Yoshikawa
authors.affiliation: Institute for Medical Science in Sports, Osaka Health Science University, Osaka, Japan; Center for Advanced Medical Engineering and Informatics, Osaka University, Osaka, Japan.
authors.forename: Norimasa
authors.initials: N
authors.lastname: Nakamura
keywords: animal models; articular cartilage; biomaterials; mesenchymal stem cells; synovial cells