title: Paediatric Living Donor Liver Transplantation: ASingle Centre Experience from Pakistan.
abstract: OBJECTIVE
  To determine the outcomes of paediatric living donor liver transplantation (LDLT) recipients from Pakistan in terms of 90-day morbidity and mortality.
  
  
  METHODS
  Cohort study.
  
  
  METHODS
  Shifa International Hospital, Islamabad, Pakistan, between April 2012 and April 2015.
  
  
  METHODS
  All patients in paediatric age group (≤ 17 years) who underwent LDLT with a minimum follow-up of 3 months, were included. All grade 2 and above complications on Clavien-Dindo system were included as morbidity. The main outcome measure was 90-day morbidity and mortality.
  
  
  RESULTS
  Fourteen paediatric LDLTs were performed. Median age of the recipients was 8.5 years ranging between 6 months and 17 years. Wilson's disease and cryptogenic cirrhosis were the most common etiologies (28.6% each). Acute liver failure was present in 5 (35.7%) patients. Overall 90-day morbidity and mortality was 71.4% and 14.2%; both were attributable to pulmonary infection. No difference was observed in morbidity (21.3% vs. 42.8%, p=0.3) and mortality rates (20% vs. 11%, p=1.0) between patients with acute and chronic liver failure. Estimated 3-year survival was 85%.
  
  
  CONCLUSIONS
  Paediatric LDLT offers a promising treatment option for acute and chronic liver failure. Mortality was attributable to post-transplant pulmonary infections.
authors.affiliation: Department of HPB and Liver Transplantation, Shifa International Hospital, Karachi.
authors.forename: Abu Bakar Hafeez
authors.initials: AB
authors.lastname: Bhatti
authors.affiliation: Department of HPB and Liver Transplantation, Shifa International Hospital, Karachi.
authors.forename: Faisal Saud
authors.initials: FS
authors.lastname: Dar
authors.affiliation: Department of Pediatrics, Shifa International Hospital, Karachi.
authors.forename: Syeda Shaheera
authors.initials: SS
authors.lastname: Hashmi
authors.affiliation: Department of HPB and Liver Transplantation, Shifa International Hospital, Karachi.
authors.forename: Haseeb
authors.initials: H
authors.lastname: Zia
authors.affiliation: Department of Pediatrics, Shifa International Hospital, Karachi.
authors.forename: Munir Iqbal
authors.initials: MI
authors.lastname: Malik
authors.affiliation: Department of Pediatrics, Shifa International Hospital, Karachi.
authors.forename: Najmul Hassan
authors.initials: NH
authors.lastname: Shah
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D007223:Infant; D017093:Liver Failure / Q000401:mortality* / Q000601:surgery*; D016031:Liver Transplantation / Q000401:mortality*; D019520:Living Donors; D008297:Male; D010154:Pakistan / Q000453:epidemiology; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology; D012720:Severity of Illness Index; D016019:Survival Analysis; D016896:Treatment Outcome