title: Hepatoid adenocarcinoma of the lung without production of α-fetoprotein: A case report and review of the literature.
abstract: Hepatoid adenocarcinoma of the lung (HAL) is a rare type of extrahepatic hepatoid adenocarcinoma. The majority of such cases that have been reported in the English literature have demonstrated elevated serum α-fetoprotein (AFP) and/or positive AFP expression on histopathological analysis, and have had poor prognoses. The current study reports an extremely rare case of HAL in the right upper lung without AFP production in a 59-year-old male patient. The patient underwent radical right upper lobectomy via video assisted thoracoscopic surgery. No signs of local recurrence or distant metastasis have been observed for 23 months after the surgery. The serum AFP level following surgery remained within the normal range. Although the diagnosis of HAL predominantly depends on pathological examination, a review of the literature demonstrates that HAL has certain characteristic features with regard to its clinical and computed tomography findings and prognoses, and clinicians should be aware that clinicians should be aware that monitoring serum AFP levels, as well as CT findings, remains important.
authors.affiliation: Department of Radiology, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China.
authors.forename: Ji Ning
authors.initials: JN
authors.lastname: Sun
authors.affiliation: Department of Radiology, Weifang Maternity and Child Care Hospital, Weifang, Shandong 261011, P.R. China.
authors.forename: Bao Long
authors.initials: BL
authors.lastname: Zhang
authors.affiliation: Department of Radiology, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China.
authors.forename: Lin Kun
authors.initials: LK
authors.lastname: Li
authors.affiliation: Department of Radiology, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China.
authors.forename: Hai Yan
authors.initials: HY
authors.lastname: Yu
authors.affiliation: Medical Imaging Research Institute, Binzhou Medical University, Yantai, Shandong 264003, P.R. China.
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
keywords: computed tomography; hepatoid adenocarcinoma; lung; α-fetoprotein