title: Asymmetric α-amination of 3-substituted oxindoles using chiral bifunctional phosphine catalysts.
abstract: A highly enantioselective α-amination of 3-substituted oxindoles with azodicarboxylates catalyzed by amino acids-derived chiral phosphine catalysts is reported. The corresponding products containing a tetrasubstituted carbon center attached to a nitrogen atom at the C-3 position of the oxindole were obtained in high yields and with up to 98% ee.
authors.affiliation: Laboratory of Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, People's Republic of China.
authors.forename: Qiao-Wen
authors.initials: QW
authors.lastname: Jin
authors.affiliation: Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, People's Republic of China.
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Chai
authors.affiliation: Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, People's Republic of China.
authors.forename: You-Ming
authors.initials: YM
authors.lastname: Huang
authors.affiliation: Laboratory of Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, People's Republic of China.
authors.forename: Gang
authors.initials: G
authors.lastname: Zou
authors.affiliation: Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, People's Republic of China.
authors.forename: Gang
authors.initials: G
authors.lastname: Zhao
keywords: 3-aminooxindoles; asymmetric catalysis; phosphine catalyst; tetrasubstituted stereogenic carbon centers