title: Intermittent administration of parathyroid hormone enhances primary stability of dental implants in a bone-reduced rabbit model.
abstract: The aim of the study was to investigate the effect of parathyroid hormone (PTH) on primary stability of dental implants in a bone-reduced model. Ten female New Zealand white rabbits underwent ovariectomy and were administered glucocorticoid to induce osteoporosis. One group was administered PTH intermittently by subcutaneous injection for 4 weeks (PTH-group) and the other group was given injections of saline for 4 weeks (Osteoporosis; OP-group). After the administration period, implants were inserted into the distal femoral epiphyses of each animal. At implant placement, insertion torque (IT) and implant stability quotient (ISQ) were measured. Histological examination revealed newly formed trabecular bone around the implant socket in the PTH-group but not in the OP-group. The trabecular bone structures in the PTH-group appeared thicker than those in the OP-group. In the PTH-group, the mean IT value was significantly greater than that in the OP-group (29.8 ± 6.2 Ncm and 10.0 ± 2.1 Ncm, respectively; P < 0.05). The ISQ value in the PTH-group was significantly higher than that in the OP-group (74.7 ± 11.2 and 55.9 ± 13.5, respectively; P < 0.05). Intermittent PTH administration could be an effective treatment for achieving favorable primary stability of dental implants in patients with osteoporosis. (J Oral Sci 58, 241-246, 2016).
authors.affiliation: Department of Advanced Prosthodontics, Hiroshima University Graduate School of Biomedical and Health Sciences.
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Oki
authors.forename: Kazuya
authors.initials: K
authors.lastname: Doi
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Makihara
authors.forename: Takayasu
authors.initials: T
authors.lastname: Kubo
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Oue
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Tsuga
mesh_terms: D000818:Animals; D015921:Dental Implants; D004195:Disease Models, Animal; D010024:Osteoporosis / Q000503:physiopathology*; D010281:Parathyroid Hormone / Q000008:administration & dosage*; D011817:Rabbits
chemical_list: D015921:Dental Implants; D010281:Parathyroid Hormone