title: Clinical outcomes and prognostic factors of adult's Ewing sarcoma family of tumors: single center experience.
abstract: OBJECTIVE
  Aim of the study was to investigate the demographics of Ewing sarcoma family of tumours (ESTF) patients, treatment alternatives, clinical outcomes, and prognostic factors for survival.
  
  
  METHODS
  We retrospectively reviewed 39 patients with ESFT who were admitted to our institute between September 2008 and September 2012.
  
  
  RESULTS
  The patients included 32 (82.1%) males and seven (17.9%) females of median age 24 (range, 18-66) years. Among the 27 patients with a primary osseous localization, 17 (43.5%) had a central axis localization. Fifteen patients (38.5%) had metastases at the time of diagnosis. Patients were followed up for a median period of 18 (range, 2-134) months. The median event-free survival (EFS) was 23 (range, 1-64) months, and the 1- and 4-year EFS were 60% and 48%, respectively. The median overall survival (OS) was 91 (range, 1-188) months, and the 1- and 4-year OS were 78% and 54%, respectively. Gender, age, primary tumor site, and local treatment modalities, either alone or in combination, did not have a significant effect on OS (p = 0.210, p = 0.617, p = 0.644, and p = 0.417, respectively). In contrast, osseous site of peripheral localization, limited stage, and metastasis to the bone significantly affected OS (p = 0.015, p < 0.001, and p = 0.042, respectively).
  
  
  CONCLUSIONS
  ESFTs are aggressive tumors with a high rate of relapse and metastatic potential. Patients with peripheral bone involvement and limited stage had a good prognosis. Appropriate surgical resection, radiotherapy, and aggressive chemotherapy regimens are recommended.
authors.affiliation: Department of Medical Oncology, Abant Izzet Baysal University, Faculty of Medicine, Bolu, Turkey.
authors.forename: Ummugul
authors.initials: U
authors.lastname: Uyeturk
authors.affiliation: Department of Medical Oncology, Ankara Oncology Education and Research Hospital, Ankara, Turkey.
authors.forename: Kaan
authors.initials: K
authors.lastname: Helvaci
authors.affiliation: Department of Medical Oncology, Ankara Oncology Education and Research Hospital, Ankara, Turkey.
authors.forename: Ayse
authors.initials: A
authors.lastname: Demirci
authors.affiliation: Department of Medical Oncology, Ankara Oncology Education and Research Hospital, Ankara, Turkey.
authors.forename: Ozlem Uysal
authors.initials: OU
authors.lastname: Sonmez
authors.affiliation: Department of Medical Oncology, Ankara Oncology Education and Research Hospital, Ankara, Turkey.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Turker
authors.affiliation: Department of Medical Oncology, Cukurova University, Faculty of Medicine, Adana, Turkey.
authors.forename: Cigdem Usul
authors.initials: CU
authors.lastname: Afsar
authors.affiliation: Department of Medical Oncology, Ankara Oncology Education and Research Hospital, Ankara, Turkey.
authors.forename: Burcin
authors.initials: B
authors.lastname: Budakoglu
authors.affiliation: Department of Medical Oncology, Ankara Oncology Education and Research Hospital, Ankara, Turkey.
authors.forename: Ulku Yalcintas
authors.initials: UY
authors.lastname: Arslan
authors.affiliation: Department of Medical Oncology, Ankara Oncology Education and Research Hospital, Ankara, Turkey.
authors.forename: Omur Berna
authors.initials: OB
authors.lastname: Oksuzoglu
authors.affiliation: Department of Medical Oncology, Ankara Oncology Education and Research Hospital, Ankara, Turkey.
authors.forename: Nurullah
authors.initials: N
authors.lastname: Zengin
keywords: Ewing's sarcoma family of tumors; adult; treatment