title: [Mechanism Study on Danggui Shaoyao San and Guizhi Fuling Wan For Treating Primary Dysmenorrheal Based on Biological Network].
abstract: OBJECTIVE
  To investigate the molecular mechanisms of Danggui Shaoyao San and Guizhi Fuling Wan for treating primary dysmenorrhea of liver depression and blood stasis syndrome by biological network method.
  
  
  METHODS
  Targets of the formula were collected from. PubMed database, and targets of primary dysmenorrhea were searched from Gene Card database. Then, the "formula-syndromes-disease" network was constructed and analyzed with Cytoscape software. Molecular docking approach was used to verify estrogen-like effect of ingredients.
  
  
  RESULTS
  The "formula-syndromes-disease" shared multiple targets, which involves a variety of important nodes, such as IL and PGF2α, and played the effects of anti-inflammatory and analgesic. Danggui Shaoyao San could influence the function of hormones, such as corticotropin releasing hormone, and inhibit hyperactivity of adrenal axis. Guizhi Fuling Wan mainly affected a series of inflammation caused by cyclooxygenase and had the effects of blood coagulation. Estrogen-like effect of Danggui Shaoyao Sanwas stronger than that of Guizhi Fuling Wan.
  
  
  CONCLUSIONS
  The novel approach will present an effective strategy for theory study of Danggui Shaoyao San and Guizhi Fuling Wan for treating primary dysmenorrhea.
authors.forename: Yun-lai
authors.initials: YL
authors.lastname: Wang
authors.forename: Si-yao
authors.initials: SY
authors.lastname: Ru
authors.forename: Qing
authors.initials: Q
authors.lastname: Fang
authors.forename: Gun-qiang
authors.initials: GQ
authors.lastname: Li
authors.forename: Yong-fu
authors.initials: YF
authors.lastname: Pan
authors.forename: Yao
authors.initials: Y
authors.lastname: Yao
authors.forename: Fan
authors.initials: F
authors.lastname: Xu
mesh_terms: D001777:Blood Coagulation; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004412:Dysmenorrhea / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D062105:Molecular Docking Simulation
chemical_list: D004365:Drugs, Chinese Herbal; C531150:danggui-shaoyao-san; C525079:guizhi-fuling