title: Antioxidant, antilipidemic and antidiabetic effects of ficusin with their effects on GLUT4 translocation and PPARγ expression in type 2 diabetic rats.
abstract: In this study, the antioxidant, antilipidemic and antidiabetic effects of ficusin isolated from Ficus carica leaves and their effects on GLUT4 translocation and PPARγ expression were evaluated in HFD-STZ induced type 2 diabetic rats. Ficusin (20 and 40 mg/kg b. wt.) lowered the levels of fasting blood glucose, plasma insulin and body weight gain, in HFD-STZ induced diabetic rats. Ficusin also significantly lowered the serum antioxidant enzymes (SOD, CAT and GPx) and lipids (TC, TG and FFA) levels to near normal. Ficusin significantly enhanced the PPARγ expression and improved the translocation and activation of GLUT4 in the adipose tissue. Molecular docking analysis exhibited promising interactions of GLUT4 and PPARγ into their active sites. This study suggests that ficusin improved the insulin sensitivity on adipose tissue and it can be used for the treatment of obesity related type 2 diabetes mellitus.
authors.affiliation: Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Chennai 600 034, India.
authors.forename: Santiagu Stephen
authors.initials: SS
authors.lastname: Irudayaraj
authors.affiliation: Division of Bioinformatics, Entomology Research Institute, Loyola College, Chennai 600 034, India.
authors.forename: Antony
authors.initials: A
authors.lastname: Stalin
authors.affiliation: Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Chennai 600 034, India.
authors.forename: Christudas
authors.initials: C
authors.lastname: Sunil
authors.affiliation: Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Chennai 600 034, India; Department of Botany and Microbiology, Addiriyah Chair for Environmental Studies, College of Science, King Saudi University, P. O. Box 2455, Riyadh 11451, Saudi Arabia. Electronic address: avdpandiyan@yahoo.co.in.
authors.forename: Veeramuthu
authors.initials: V
authors.lastname: Duraipandiyan
authors.affiliation: Department of Botany and Microbiology, Addiriyah Chair for Environmental Studies, College of Science, King Saudi University, P. O. Box 2455, Riyadh 11451, Saudi Arabia.
authors.forename: Naif Abdullah
authors.initials: NA
authors.lastname: Al-Dhabi
authors.affiliation: Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Chennai 600 034, India; Division of Bioinformatics, Entomology Research Institute, Loyola College, Chennai 600 034, India; Visiting Professor Programme, Deanship of Scientific Research, College of Science, King Saudi University, Saudi Arabia.
authors.forename: Savarimuthu
authors.initials: S
authors.lastname: Ignacimuthu
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D001786:Blood Glucose / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D030681:Ficus / Q000737:chemistry; D005363:Ficusin / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D051275:Glucose Transporter Type 4 / Q000378:metabolism*; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D047495:PPAR gamma / Q000378:metabolism*; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D051275:Glucose Transporter Type 4; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D007328:Insulin; D008055:Lipids; D047495:PPAR gamma; D005363:Ficusin
keywords: Ficus carica; Ficusin; GLUT4; High fat diet; PPARγ; Streptozotocin