title: Bone Marrow Is a Reservoir for Cardiac Resident Stem Cells.
abstract: Resident cardiac stem cells (CSCs) represent a responsive stem cell reservoir within the adult myocardium and have a significant function in myocardial homeostasis and injury. However, the distribution, origin, homing and possible therapeutic benefits of CSCs are still under discussion. Here we investigated whether bone marrow (BM) stem cells could contribute to repopulating the pool of CSCs in heart. The engraftment of BM cells in heart was detected at a low level after BM transplantation (BMT) and ischemia/reperfusion (I/R) could increase BM cells engraftment but not significant. We clarified that more than 50% CSCs are derived from BM and confirmed that BM-derived CSCs have similar characteristics with the host CSCs. Furthermore, we transplanted BM-derived CSCs into heart ischemia models and presented evidence for the first time that BM-derived CSCs can differentiate into cardiomyocytes in vivo. In conclusions, BM stem cells could be a potential back-up source of CSCs for restoring heart function after injury or maintaining homeostasis of CSCs.
authors.affiliation: Nankai University School of Medicine, Tianjin, China.|The Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, the College of Life Science, Tianjin, China.
authors.forename: Na
authors.initials: N
authors.lastname: Liu
authors.affiliation: Department of Cardiology, Tianjin Union Medical Center, Nankai University Affiliated Hospital, Tianjin, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Qi
authors.affiliation: State Key Lab of Experimental Hematology, Institute of Hematology &Hospital of Blood Diseases, Chinese Academy of Medical Sciences, Tianjin, China.
authors.forename: Zhibo
authors.initials: Z
authors.lastname: Han
authors.affiliation: Nankai University School of Medicine, Tianjin, China.|Beijing Institute of Health and Stem Cells, No. 1 Kangding Road, BDA, Beijing, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Liang
authors.affiliation: The Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, the College of Life Science, Tianjin, China.
authors.forename: Deling
authors.initials: D
authors.lastname: Kong
authors.affiliation: State Key Lab of Experimental Hematology, Institute of Hematology &Hospital of Blood Diseases, Chinese Academy of Medical Sciences, Tianjin, China.|Beijing Institute of Health and Stem Cells, No. 1 Kangding Road, BDA, Beijing, China.
authors.forename: Zhongchao
authors.initials: Z
authors.lastname: Han
authors.affiliation: Department of Radiology, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Shihua
authors.initials: S
authors.lastname: Zhao
authors.affiliation: Department of Nuclear Medicine, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Disease, Peking Union Medical College &Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Zuo-Xiang
authors.initials: ZX
authors.lastname: He
authors.affiliation: Nankai University School of Medicine, Tianjin, China.|The Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, the College of Life Science, Tianjin, China.
authors.forename: Zongjin
authors.initials: Z
authors.lastname: Li
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000378:metabolism* / Q000473:pathology; D016026:Bone Marrow Transplantation; D002454:Cell Differentiation; D051379:Mice; D008822:Mice, Transgenic; D017202:Myocardial Ischemia / Q000378:metabolism* / Q000473:pathology; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D032383:Myocytes, Cardiac / Q000378:metabolism* / Q000473:pathology; D013234:Stem Cells / Q000378:metabolism* / Q000473:pathology