title: MicroRNA-210 and its theranostic potential.
abstract: MicroRNAs (miRNAs) are a set of small single-stranded noncoding RNAs with diverse biological functions. As a prototypical hypoxamir, human microRNA-210 (hsa-miR-210) is one of the most widely studied miRNAs thus far. In addition to its involvement in sophisticated regulation of numerous biological processes, miR-210 has also been shown to be associated with the development of different human diseases including various types of cancers, cardiovascular and cerebrovascular diseases, and immunological diseases. Given its multi-faceted functions, miR-210 may serve as a novel and promising theranostic target for prevention and treatment of diseases. Areas covered: This review aims to provide a comprehensive overview of miR-210, the regulation of its expression, biological functions and molecular mechanisms, with particular emphasis on its diagnostic and therapeutic potential. Expert opinion: Although the exact roles of miR-210 in various diseases have not been fully clarified, targeting miR-210 may be a promising therapeutic strategy. Further investigations are also needed to facilitate therapeutic-clinical applications of miR-210 in human diseases.
authors.affiliation: a Department of Epidemiology and Biostatistics , School of Public Health, Anhui Medical University , Hefei , Anhui , China.|b Anhui Provincial Laboratory of Population Health & Major Disease Screening and Diagnosis , Anhui Medical University , Hefei , Anhui , China.|c The First Affiliated Hospital of Anhui Medical University , Hefei , Anhui , China.
authors.forename: Chun-Xia
authors.initials: CX
authors.lastname: Ren
authors.affiliation: a Department of Epidemiology and Biostatistics , School of Public Health, Anhui Medical University , Hefei , Anhui , China.|b Anhui Provincial Laboratory of Population Health & Major Disease Screening and Diagnosis , Anhui Medical University , Hefei , Anhui , China.
authors.forename: Rui-Xue
authors.initials: RX
authors.lastname: Leng
authors.affiliation: a Department of Epidemiology and Biostatistics , School of Public Health, Anhui Medical University , Hefei , Anhui , China.|b Anhui Provincial Laboratory of Population Health & Major Disease Screening and Diagnosis , Anhui Medical University , Hefei , Anhui , China.
authors.forename: Yin-Guang
authors.initials: YG
authors.lastname: Fan
authors.affiliation: a Department of Epidemiology and Biostatistics , School of Public Health, Anhui Medical University , Hefei , Anhui , China.|b Anhui Provincial Laboratory of Population Health & Major Disease Screening and Diagnosis , Anhui Medical University , Hefei , Anhui , China.
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Pan
authors.affiliation: d Faculty of Health and Medical Sciences , University of Surrey , Guildford , UK.
authors.forename: Chang-Hao
authors.initials: CH
authors.lastname: Wu
authors.affiliation: a Department of Epidemiology and Biostatistics , School of Public Health, Anhui Medical University , Hefei , Anhui , China.|b Anhui Provincial Laboratory of Population Health & Major Disease Screening and Diagnosis , Anhui Medical University , Hefei , Anhui , China.
authors.forename: Dong-Qing
authors.initials: DQ
authors.lastname: Ye
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000235:genetics / Q000517:prevention & control / Q000628:therapy; D002561:Cerebrovascular Disorders / Q000235:genetics / Q000517:prevention & control / Q000628:therapy; D006801:Humans; D007154:Immune System Diseases / Q000235:genetics / Q000517:prevention & control / Q000628:therapy; D035683:MicroRNAs / Q000235:genetics*; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000235:genetics / Q000517:prevention & control / Q000628:therapy; D000068936:Theranostic Nanomedicine / Q000379:methods*
chemical_list: C543800:MIRN210 microRNA, human; D035683:MicroRNAs
keywords: MicroRNA-210; biomarker; hypoxia; theranostic target