title: Enhancing antitumor activity of silver nanoparticles by modification with cell-penetrating peptides.
abstract: Recently, silver nanoparticles (AgNPs) have been used for cancer treatment. To achieve a successful anticancer activity, AgNP needs to be delivered sufficiently to the cells. Cell-penetrating peptides (CPPs) are small cationic peptides that have ability to transport various cargos across cell membranes. In this study, a strategy was developed for cancer treatment, where AgNP modified with CPPs displayed dramatically antitumor activity in MCF-7 cell lines. Peptides-modified AgNPs showed significant enhancement in killing tumor cells by increasing the uptake of AgNP into cell lines and could be a new class of nano-drug for cancer treatment.
authors.affiliation: a Research Center for Pharmaceutical Nanotechnology and Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences , Tabriz University of Medical Sciences , Tabriz , Iran.|b Student Research Committee , Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Samad
authors.initials: S
authors.lastname: Mussa Farkhani
authors.affiliation: a Research Center for Pharmaceutical Nanotechnology and Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences , Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Abbas
authors.initials: A
authors.lastname: Asoudeh Fard
authors.affiliation: c Liver and Gastrointestinal Diseases Research Center and Faculty of Pharmacy , Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Parvin
authors.initials: P
authors.lastname: Zakeri-Milani
authors.affiliation: d Biotechnology Research Center and Faculty of Pharmacy , Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Javid
authors.initials: J
authors.lastname: Shahbazi Mojarrad
authors.affiliation: e Drug Applied Research Center and Faculty of Pharmacy , Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Hadi
authors.initials: H
authors.lastname: Valizadeh
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D057846:Cell-Penetrating Peptides / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells; D053768:Metal Nanoparticles; D012834:Silver / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D057846:Cell-Penetrating Peptides; D012834:Silver
keywords: Anticancer; cell-penetrating peptides; cytotoxicity; silver nanoparticles