title: Isavuconazole in the treatment of invasive aspergillosis and mucormycosis infections.
abstract: We have a limited arsenal with which to treat invasive fungal infections caused by Aspergillus and Mucorales. The morbidity and mortality for both pathogens remains high. A triazole antifungal, isavuconazole, was recently granted approval by the US Food and Drug Administration and the European Medicines Agency for the treatment of invasive aspergillosis and mucormycosis. A randomized double-blind comparison trial for the treatment of invasive aspergillosis found isavuconazole noninferior to voriconazole. A separate, open-label study evaluating the efficacy of isavuconazole in the treatment of mucormycosis found comparable response rates to amphotericin B and posaconazole treated historical controls. The prodrug isavuconazonium sulfate is commercially available in both an oral and intravenous formulation and is generally well tolerated. Isavuconazole's broad spectrum of activity, limited side effect profile, and favorable pharmacokinetics will likely solidify its place in therapy.
authors.affiliation: Department of Inpatient Pharmacy, University of California - Davis, Sacramento, USA; Department of Clinical Sciences, Touro University College of Pharmacy, Vallejo, USA.
authors.forename: Monica A
authors.initials: MA
authors.lastname: Donnelley
authors.affiliation: Department of Inpatient Pharmacy, University of California - Davis, Sacramento, USA.
authors.forename: Elizabeth S
authors.initials: ES
authors.lastname: Zhu
authors.affiliation: Department of Medicine, Division of Infectious Diseases, University of California - Davis, Davis, CA, USA.
authors.forename: George R
authors.initials: GR
authors.lastname: Thompson
keywords: antifungal; clinical efficacy; isavuconazonium; mold infection; mucor; new agent; pharmacodynamics; pharmacokinetics; therapy; zygomycosis