title: IRF-3 gene polymorphisms are associated with the susceptibility to and the survival in chronic lymphocytic leukemia and could also serve as an auxiliary index.
abstract: The objective of this article was to investigate the relationship between IRF-3 gene polymorphisms and the susceptibility and prognosis of CLL. Between January 2011 and August 2012, 108 CLL patients and 112 healthy were enrolled in the study. DHPLC and Shesis software were applied in our study. In rs7251, CG genotype may increase the CLL risk. In the rs2304206, the alleles T may increase the CLL risk. The GTC haplotype can decrease the CLL risk in normal people, the GTT haplotype can increase the CLL risk in normal people. After treatment, in the rs7251, the event-free survival (EFS) in patients carrying CC genotype was higher than those carrying CG + GG genotype. In the rs2304206, the EFS in patients carrying CC genotype was higher than those carrying CT + TT genotype. IRF-3 gene polymorphisms were associated with the susceptibility and prognosis of CLL, it can be used as an auxiliary index for clinical detection of CLL.
authors.affiliation: a Department of Clinical Laboratory , Huzhou Central Hospital , Huzhou , P.R. China.
authors.forename: Zong-Xin
authors.initials: ZX
authors.lastname: Zhang
authors.affiliation: a Department of Clinical Laboratory , Huzhou Central Hospital , Huzhou , P.R. China.
authors.forename: Cui-Fen
authors.initials: CF
authors.lastname: Shen
authors.affiliation: b Department of Hematology , Huzhou Central Hospital , Huzhou , P.R. China.
authors.forename: Li-Hong
authors.initials: LH
authors.lastname: Shou
authors.affiliation: b Department of Hematology , Huzhou Central Hospital , Huzhou , P.R. China.
authors.forename: Qiu
authors.initials: Q
authors.lastname: Fang
mesh_terms: D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D050838:Interferon Regulatory Factor-3 / Q000235:genetics*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality*; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D012307:Risk Factors; D017422:Sequence Analysis, DNA; D016019:Survival Analysis
chemical_list: D050838:Interferon Regulatory Factor-3
keywords: Chronic lymphocytic leukemia; gene polymorphism; haplotyping; interferon regulatory factor-3; prognosis; susceptibility