title: [Central nervous system lymphoma revealed by lymphocytic meningitis in a patient with systemic lupus erythematosus: An unusual association].
abstract: BACKGROUND
  We report an unusual observation of central nervous system (CNS) lymphoma in a 60-year-old woman with systemic lupus erythematosus and fatal outcome.
  
  
  METHODS
  The patient had systemic erythematosus lupus for 7 years, treated with mycophenolate mofetil and developed lymphocytic meningitis in 2015 associated to the presence of EBV in the cerebrospinal fluid and a necrotic vermis' lesion. Diagnosis of large B-cell lymphoma was histologically confirmed from stereotaxic biopsy, shortly before she died from neurological complications.
  
  
  CONCLUSIONS
  Even though the current association is unusual, lymphocytic meningitis with hypoglycorrachia in patients with systemic lupus erythematosus may reveal CNS lymphoma and diagnosis confirmation requires stereotaxic biopsy in order not to delay specific therapeutic management.
authors.affiliation: Département de médecine interne, hôpital Fernand-Widal, groupe hospitalier Lariboisière, AP-HP, 2, rue Ambroise-Paré, 75475 Paris cedex 10, France; UMR-S1144, UFR de médecine Paris-Diderot, 10, avenue de Verdun, 75010 Paris, France. Electronic address: melanie.roriz@aphp.fr.
authors.forename: M
authors.initials: M
authors.lastname: Roriz
authors.affiliation: Département de médecine interne, hôpital Fernand-Widal, groupe hospitalier Lariboisière, AP-HP, 2, rue Ambroise-Paré, 75475 Paris cedex 10, France.
authors.forename: A
authors.initials: A
authors.lastname: Lopes
authors.affiliation: Département de médecine interne, hôpital Fernand-Widal, groupe hospitalier Lariboisière, AP-HP, 2, rue Ambroise-Paré, 75475 Paris cedex 10, France.
authors.forename: I
authors.initials: I
authors.lastname: Jarrin
authors.affiliation: Département de médecine interne, hôpital Fernand-Widal, groupe hospitalier Lariboisière, AP-HP, 2, rue Ambroise-Paré, 75475 Paris cedex 10, France; UMR-S1144, UFR de médecine Paris-Diderot, 10, avenue de Verdun, 75010 Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Lechtman
authors.affiliation: Service d'anatomopathologie, hôpital Lariboisière, AP-HP, 2, rue Ambroise-Paré, 75010 Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Polivka
authors.affiliation: Département de médecine interne, hôpital Fernand-Widal, groupe hospitalier Lariboisière, AP-HP, 2, rue Ambroise-Paré, 75475 Paris cedex 10, France; UMR-S1144, UFR de médecine Paris-Diderot, 10, avenue de Verdun, 75010 Paris, France.
authors.forename: J-F
authors.initials: JF
authors.lastname: Bergmann
authors.affiliation: Département de médecine interne, hôpital Fernand-Widal, groupe hospitalier Lariboisière, AP-HP, 2, rue Ambroise-Paré, 75475 Paris cedex 10, France; UMR-S1144, UFR de médecine Paris-Diderot, 10, avenue de Verdun, 75010 Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Sène
authors.affiliation: Département de médecine interne, hôpital Fernand-Widal, groupe hospitalier Lariboisière, AP-HP, 2, rue Ambroise-Paré, 75475 Paris cedex 10, France; UMR-S1144, UFR de médecine Paris-Diderot, 10, avenue de Verdun, 75010 Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Mouly
mesh_terms: D016543:Central Nervous System Neoplasms / Q000150:complications / Q000175:diagnosis*; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D017254:Leukemic Infiltration / Q000150:complications; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000175:diagnosis*; D008223:Lymphoma / Q000150:complications / Q000175:diagnosis*; D008581:Meningitis / Q000175:diagnosis* / Q000209:etiology; D008875:Middle Aged
keywords: Central nervous system; Lupus érythémateux systémique; Lymphoma; Lymphome; Meningitis; Méningite; Systemic erythematosus lupus; Système nerveux central