title: Lipid profiles in a large cohort of Italian children with Down syndrome.
abstract: OBJECTIVE
  Results of epidemiological studies of lipid profiles in individuals with Down Syndrome (DS) in different settings showed discordant results but laboratory norms for this population has been lacking. The aim of our study is to evaluate lipid profiles in a large population of Italian children with DS.
  
  
  METHODS
  Lipid profiles of 357 patients with diagnosis of DS were recorded.
  
  
  RESULTS
  Multiple linear regression was employed to estimate models for each lipid fraction as a function of sex and age in patients with DS.
  
  
  CONCLUSIONS
  The main contribution of this paper is to provide data about lipid profile on a large cohort of people with Down syndrome. Long-term surveillance will be crucial to establish if this specific lipid profile may translate into increased morbidity and mortality from cardiovascular diseases (CVD).
authors.affiliation: Rare Diseases and Medical Genetic Unit, Bambino Gesù Children's Hospital, Rome, Italy. Electronic address: psabrina.buonuomo@opbg.net.
authors.forename: Paola Sabrina
authors.initials: PS
authors.lastname: Buonuomo
authors.affiliation: Rare Diseases and Medical Genetic Unit, Bambino Gesù Children's Hospital, Rome, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Bartuli
authors.affiliation: Rare Diseases and Medical Genetic Unit, Bambino Gesù Children's Hospital, Rome, Italy.
authors.forename: Gerarda
authors.initials: G
authors.lastname: Mastrogiorgio
authors.affiliation: Pediatric and Infectious Disease Unit, Bambino Gesù Children's Hospital, Rome, Italy.
authors.forename: Annachiara
authors.initials: A
authors.lastname: Vittucci
authors.affiliation: Pediatric and Infectious Disease Unit, Bambino Gesù Children's Hospital, Rome, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Di Camillo
authors.affiliation: Pediatric and Infectious Disease Unit, Bambino Gesù Children's Hospital, Rome, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Bianchi
authors.affiliation: Rheumatology Unit, Bambino Gesù Children's Hospital, Rome, Italy.
authors.forename: Denise
authors.initials: D
authors.lastname: Pires Marafon
authors.affiliation: Pediatric and Infectious Disease Unit, Bambino Gesù Children's Hospital, Rome, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Villani
authors.affiliation: Pediatric and Infectious Disease Unit, Bambino Gesù Children's Hospital, Rome, Italy.
authors.forename: Diletta
authors.initials: D
authors.lastname: Valentini
mesh_terms: D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D004314:Down Syndrome / Q000097:blood* / Q000453:epidemiology / Q000401:mortality; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008055:Lipids / Q000097:blood*; D008297:Male; D055442:Metabolome; D055432:Metabolomics; D009765:Obesity; D050177:Overweight; D011159:Population Surveillance
chemical_list: D008055:Lipids
keywords: Cardiovascular disease; Down syndrome; Health supervision; Lipids; Prevention