title: [Early-onset and late-onset male hypogonadotropic hypogonadism and osteoporosis].
abstract: Hypogonadism is classified into two major clinical entities, namely early-onset hypogonadism and late-onset hypogonadism. The former is characterized by the malfunction of hypothalamo-pituitary-gonadal(testicular)axis or by the primary hypofunction of testes(e.g. Klinefelter's syndrome). The latter is summarized as LOH syndrome which is attributed to the dropped level of bioavailable testosterone. In these diseases testosterone is the key molecule which may cause various symptoms relating not only to physical health but also to mental or psychologic health. In this review issues concerning bone health in these disease are described.
authors.affiliation: Department of Urology, Dokkyo Medical University, Koshigaya Hospital, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Okada
authors.affiliation: Department of Urology, Dokkyo Medical University, Koshigaya Hospital, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Shin
authors.affiliation: Department of Urology, Dokkyo Medical University, Koshigaya Hospital, Japan.
authors.forename: Yoshitomo
authors.initials: Y
authors.lastname: Kobori
mesh_terms: D017668:Age of Onset; D015519:Bone Density; D020022:Genetic Predisposition to Disease; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy / Q000378:metabolism; D008297:Male; D010024:Osteoporosis / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D013739:Testosterone / Q000378:metabolism / Q000627:therapeutic use
chemical_list: D013739:Testosterone