title: Ethanol Extracts of Selected Cyathea Species Decreased Cell Viability and Inhibited Growth in MCF 7 Cell Line Cultures.
abstract: Cancer is the cause of more than 6 million deaths worldwide every year. For centuries, medicinal plants have been used in the treatment of cancer. Chemotherapy, radiotherapy, surgery and acupuncture point stimulation are also used to treat cancer. The present study was intended to reveal the cytotoxic and anticancer potential of selected Cyathea species and to highlight their importance in the pharmaceutical industry for the development of cost-effective drugs. Cytotoxic studies using brine shrimp lethality bioassays and MCF 7 cell line cultures were carried out. Compared to petroleum ether, chloroform and acetone extracts, the ethanol extracts of selected Cyathea species were found to be more effective against brine shrimps. The ethanol extracts were further subjected to 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) cell proliferation assays. A decrease in cell viability and an increase in growth inhibition were observed for the MCF 7 cell line. The maximum percentage of cell inhibition was observed in Cyathea crinit, followed by Cyathea nilgirensis and Cyathea gigantea. The results of the present study suggest that Cyathea species are an effective source of cytotoxic compounds.
authors.affiliation: Centre for Plant Biotechnology, Department of Botany, St. Xavier's College (Autonomous), Palayamkottai, Tamil Nadu, India.
authors.forename: Narayanan
authors.initials: N
authors.lastname: Janakiraman
authors.affiliation: Centre for Plant Biotechnology, Department of Botany, St. Xavier's College (Autonomous), Palayamkottai, Tamil Nadu, India. Electronic address: ptcjohnson@gmail.com.
authors.forename: Marimuthu
authors.initials: M
authors.lastname: Johnson
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects*; D029624:Ferns / Q000737:chemistry*; D006801:Humans; D061986:MCF-7 Cells; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry
chemical_list: D010936:Plant Extracts
keywords: Cyathea; MCF 7 cells; cytotoxicity; lethality