title: Confirmed case of Zika virus congenital infection, Spain, March 2016.
abstract: We describe Zika virus (ZIKV) vertical transmission in an imported case in Spain, in a 17-week pregnant woman. ZIKV IgG, IgM and RNA were detected in serum in week 17. At 19 weeks, ultrasound scan revealed fetal malformations and ZIKV was detected in the amniotic fluid. Pregnancy was terminated at week 21; autopsy of the fetus revealed bilateral hydrocephalus, brain microcalcifications and arthrogryposis multiplex congenita. ZIKV was detected in the umbilical cord and brain tissue.
authors.affiliation: Microbiology Department, University Hospital of Vigo, Spain.
authors.forename: Sonia
authors.initials: S
authors.lastname: Perez
authors.forename: Ruben
authors.initials: R
authors.lastname: Tato
authors.forename: Jorge Julio
authors.initials: JJ
authors.lastname: Cabrera
authors.forename: Alberto
authors.initials: A
authors.lastname: Lopez
authors.forename: Olga
authors.initials: O
authors.lastname: Robles
authors.forename: Eugenio
authors.initials: E
authors.lastname: Paz
authors.forename: Amparo
authors.initials: A
authors.lastname: Coira
authors.forename: Maria Paz
authors.initials: MP
authors.lastname: Sanchez-Seco
authors.forename: Ana
authors.initials: A
authors.lastname: Vazquez
authors.forename: Raquel
authors.initials: R
authors.lastname: Carballo
authors.forename: Carlos
authors.initials: C
authors.lastname: Quintas
authors.forename: Anxela
authors.initials: A
authors.lastname: Pousa
mesh_terms: D000015:Abnormalities, Multiple / Q000175:diagnosis / Q000821:virology*; D000028:Abortion, Induced; D000653:Amniotic Fluid / Q000821:virology*; D001176:Arthrogryposis / Q000000981:diagnostic imaging / Q000821:virology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods; D013030:Spain; D055815:Young Adult; D000071243:Zika Virus Infection / Q000151:congenital* / Q000175:diagnosis* / Q000821:virology*
keywords: Flaviviridae; Zika virus; imported viral diseases; pregnancy; sexually transmitted infections; surveillance; vector-borne infections