title: Fungal proteinaceous compounds with multiple biological activities.
abstract: Fungi comprise organisms like molds, yeasts and mushrooms. They have been used as food or medicine for a long time. A large number of fungal proteins or peptides with diverse biological activities are considered as antibacterial, antifungal, antiviral and anticancer agents. They encompass proteases, ribosome inactivating proteins, defensins, hemolysins, lectins, laccases, ribonucleases, immunomodulatory proteins, and polysaccharopeptides. The target of the present review is to update the status of the various bioactivities of these fungal proteins and peptides and discuss their therapeutic potential.
authors.affiliation: School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China. b021770@mailserv.cuhk.edu.hk.
authors.forename: Tzi Bun
authors.initials: TB
authors.lastname: Ng
authors.affiliation: School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China. chifaicheung@cuhk.edu.hk.
authors.forename: Randy Chi Fai
authors.initials: RCF
authors.lastname: Cheung
authors.affiliation: School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China. b111590@mailserv.cuhk.edu.hk.
authors.forename: Jack Ho
authors.initials: JH
authors.lastname: Wong
authors.affiliation: State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, School of Medicine, Shenzhen University, Nanhai Ave 3688, 518060, Shenzhen, Guangdong, People's Republic of China.
authors.forename: Yau Sang
authors.initials: YS
authors.lastname: Chan
authors.affiliation: School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
authors.forename: Xiuli
authors.initials: X
authors.lastname: Dan
authors.affiliation: School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
authors.forename: Wenliang
authors.initials: W
authors.lastname: Pan
authors.affiliation: State Key Laboratory for Agrobiotechnology and Department of Microbiology, China Agricultural University, Beijing, 100193, China.
authors.forename: Hexiang
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Social Medicine, College of Public Health, Xinjiang Medical University, Urumqi, 830011, China.
authors.forename: Suzhen
authors.initials: S
authors.lastname: Guan
authors.affiliation: Biomedical and Tissue Engineering Research Group, Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital, 34 Hospital Road, Hong Kong, China.
authors.forename: Ki
authors.initials: K
authors.lastname: Chan
authors.affiliation: College of Biological Sciences and Technology, Fuzhou University, Fuzhou, Fujian, China.|Fujian Key Laboratory of Marine Enzyme Engineering, Fuzhou, Fujian, China.
authors.forename: Xiuyun
authors.initials: X
authors.lastname: Ye
authors.affiliation: Department of Microbiology, Nankai University, Tianjin, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, School of Medicine, Shenzhen University, Nanhai Ave 3688, 518060, Shenzhen, Guangdong, People's Republic of China.
authors.forename: Lixin
authors.initials: L
authors.lastname: Xia
authors.affiliation: School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China. chanwy@cuhk.edu.hk.
authors.forename: Wai Yee
authors.initials: WY
authors.lastname: Chan
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D023082:Defensins / Q000494:pharmacology; D005656:Fungal Proteins / Q000378:metabolism* / Q000494:pharmacology*; D005658:Fungi / Q000378:metabolism*; D007155:Immunologic Factors / Q000494:pharmacology; D054788:Ribosome Inactivating Proteins / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D023082:Defensins; D005656:Fungal Proteins; D007155:Immunologic Factors; D054788:Ribosome Inactivating Proteins
keywords: Antibacterial; Anticancer; Antifungal; Antiviral; Fungi; Proteins