title: Impact of Open Laparoscopy in Patients Under Suspicion of Ovarian Cancer.
abstract: OBJECTIVE
  Feasibility and value of diagnostic open laparoscopy (DOL) was assessed in patients presenting under suspicion of advanced ovarian cancer (AOC) mostly with large-volume ascites.
  
  
  METHODS
  This retrospective study analyzed 143 consecutive patients who underwent DOL for histopathological verification of AOC performed from 2002 to 2012.
  
  
  RESULTS
  Out of the 143 patients presenting at our Center with an ovarian mass and mostly with ascites under suspicion of ovarian cancer, we diagnosed 125 AOCs, three AOCs with three concomitant tumors of other origin, and 15 other diseases causing an ovarian mass and ascites mimicking AOC (e.g. gastrointestinal malignancies, tuberculosis, mesothelioma, endometrial cancer and benign conditions).
  
  
  CONCLUSIONS
  DOL can be considered a valid and safe diagnostic tool for histopathologically verifying epithetlial ovarian cancer and preventing patients with other diagnoses undergoing the wrong course of therapy.
authors.affiliation: Department of Gynecology and Obstetrics, Center for Integrated Oncology (CIO) Köln/Bonn, University Hospital Bonn, Bonn, Germany lars.schroeder@ukb.uni-bonn.de.
authors.forename: Lars
authors.initials: L
authors.lastname: Schröder
authors.affiliation: Department of Gynecology and Obstetrics, Center for Integrated Oncology (CIO) Köln/Bonn, University Hospital Bonn, Bonn, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Rudlowski
authors.affiliation: Department of Gynecology and Obstetrics, Center for Integrated Oncology (CIO) Köln/Bonn, University Hospital Bonn, Bonn, Germany.
authors.forename: Paula
authors.initials: P
authors.lastname: Kutkuhn
authors.affiliation: Department of Gynecology and Obstetrics, Center for Integrated Oncology (CIO) Köln/Bonn, University Hospital Bonn, Bonn, Germany.
authors.forename: Alina
authors.initials: A
authors.lastname: Abramian
authors.affiliation: Department of Gynecology and Obstetrics, Center for Integrated Oncology (CIO) Köln/Bonn, University Hospital Bonn, Bonn, Germany.
authors.forename: Christina
authors.initials: C
authors.lastname: Kaiser
authors.affiliation: Department of Gynecology and Obstetrics, Center for Integrated Oncology (CIO) Köln/Bonn, University Hospital Bonn, Bonn, Germany.
authors.forename: Walther Christian
authors.initials: WC
authors.lastname: Kuhn
authors.affiliation: Department of Gynecology and Obstetrics, Center for Integrated Oncology (CIO) Köln/Bonn, University Hospital Bonn, Bonn, Germany.
authors.forename: Mignon-Denise
authors.initials: MD
authors.lastname: Keyver-Paik
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018394:CA-125 Antigen / Q000097:blood; D005260:Female; D006801:Humans; D010535:Laparoscopy; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000097:blood / Q000175:diagnosis* / Q000601:surgery; D010051:Ovarian Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000601:surgery; D012189:Retrospective Studies
chemical_list: D018394:CA-125 Antigen
keywords: Advanced ovarian cancer; ascites; diagnostic open laparoscopy; epithelial ovarian cancer; neoadjuvant chemotherapy; primary debulking surgery; sampling