title: FZD6, targeted by miR-21, represses gastric cancer cell proliferation and migration via activating non-canonical wnt pathway.
abstract: FZD6 plays crucial roles in human tumorigenesis. However, its mechanism in regulating cancers has not been fully elucidated. In the study, we found that FZD6 repressed gastric cancer cell proliferation and migration via activating non-canonical wnt pathway. In addition, non-canonical wnt pathway ameliorated expression of canonical wnt pathway. We also demonstrated that the FZD6 was involved in miR-21-dependent effects in the canonical and non-canonical wnt pathways in gastric cancer. These findings provide a better understanding of the development and progression of gastric cancer and may be an important implication for future therapy.
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital with Nanjing Medical UniversityNanjing, Jiangsu 210000, China; The First Clinical Medical College, Nanjing Medical UniversityNanjing, Jiangsu 210000, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Yan
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital with Nanjing Medical UniversityNanjing, Jiangsu 210000, China; The First Clinical Medical College, Nanjing Medical UniversityNanjing, Jiangsu 210000, China.
authors.forename: Tingyu
authors.initials: T
authors.lastname: Liu
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital with Nanjing Medical UniversityNanjing, Jiangsu 210000, China; The First Clinical Medical College, Nanjing Medical UniversityNanjing, Jiangsu 210000, China.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital with Nanjing Medical UniversityNanjing, Jiangsu 210000, China; The First Clinical Medical College, Nanjing Medical UniversityNanjing, Jiangsu 210000, China.
authors.forename: Yini
authors.initials: Y
authors.lastname: Dang
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital with Nanjing Medical UniversityNanjing, Jiangsu 210000, China; The First Clinical Medical College, Nanjing Medical UniversityNanjing, Jiangsu 210000, China.
authors.forename: Chengqiang
authors.initials: C
authors.lastname: Yin
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital with Nanjing Medical UniversityNanjing, Jiangsu 210000, China; The First Clinical Medical College, Nanjing Medical UniversityNanjing, Jiangsu 210000, China.
authors.forename: Guoxin
authors.initials: G
authors.lastname: Zhang
keywords: FZD6; Wnt pathway; gastric cancer; miR-21