title: The role of mean platelet volume in patients with Takayasu arteritis.
abstract: Background Takayasu arteritis is a chronic non-specific inflammatory disease and mean platelet volume can either be decreased or increased during inflammation. However, there are no published data to confirm an association between mean platelet volume and Takayasu arteritis. Our aim was to evaluate the role of mean platelet volume in patients with Takayasu arteritis. Methods A total of 119 consecutive patients with Takayasu arteritis and 217 healthy individuals were included in this study. Forty-five Takayasu arteritis patients with active disease were followed with prednisone therapy. Results Mean platelet volume of patients was low compared with control groups (10.1 ± 1.47 fL vs. 11.2 ± 0.91 fL; P < 0.001). Mean platelet volume was lower in active Takayasu arteritis than in inactive Takayasu arteritis patients (9.3 ± 1.39 fL vs. 10.6 ± 1.28 fL; P< 0.001). Mean platelet volume values were significantly increased after prednisone treatment (9.3 ± 1.45 fL vs. 10.5 ± 1.29 fL; P < 0.001). Mean platelet volume negatively correlated with C-reactive protein, erythrocyte sedimentation rate, neutrophil count and platelet count (r = - 0.219, P = 0.018; r = - 0.296, P < 0.001; r = - 0.273, P = 0.003; r =-0.486, P< 0.001), and positively correlated with platelet distribution width (r=0.304, P ≤ 0.001) in patients with Takayasu arteritis. An inverse correlation between mean platelet volume and erythrocyte sedimentation rate was observed in active Takayasu arteritis patients (r = -0.406, P = 0.010). In multiple linear regression analysis, mean platelet volume was independently correlated with erythrocyte sedimentation rate in patients with Takayasu arteritis. Conclusions Our results suggest that mean platelet volume may identify active disease in patients with Takayasu arteritis, and the values of mean platelet volume may help to establish remission of active disease after treatment in Takayasu arteritis patients.
authors.affiliation: 1 Department of Laboratory Medicine, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China.
authors.forename: You-Fan
authors.initials: YF
authors.lastname: Peng
authors.affiliation: 2 Department of Dermatology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Guo
authors.affiliation: 1 Department of Laboratory Medicine, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China.
authors.forename: Yi-Bin
authors.initials: YB
authors.lastname: Deng
mesh_terms: D000293:Adolescent; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000378:metabolism / Q000473:pathology*; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D016014:Linear Models; D008297:Male; D063847:Mean Platelet Volume; D009504:Neutrophils / Q000473:pathology; D011241:Prednisone / Q000627:therapeutic use; D012720:Severity of Illness Index; D013625:Takayasu Arteritis / Q000097:blood* / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology
chemical_list: D000893:Anti-Inflammatory Agents; D015415:Biomarkers; D002097:C-Reactive Protein; D011241:Prednisone
keywords: Takayasu arteritis; erythrocyte sedimentation rate; mean platelet volume