title: Peripheral brain-derived neurotrophic factor is related to cardiovascular risk factors in active and inactive elderly men.
abstract: Regular exercise plays an important preventive and therapeutic role in heart and vascular diseases, and beneficially affects brain function. In blood, the effects of exercise appear to be very complex and could include protection of vascular endothelial cells via neurotrophic factors and decreased oxidative stress. The purpose of this study was to identify the age-related changes in peripheral brain-derived neurotrophic factor (BDNF) and its relationship to oxidative damage and conventional cardiovascular disease (CVD) biomarkers, such as atherogenic index, C-reactive protein (hsCRP) and oxidized LDL (oxLDL), in active and inactive men. Seventeen elderly males (61-80 years) and 17 young males (20-24 years) participated in this study. According to the 6-min Åstrand-Rhyming bike test, the subjects were classified into active and inactive groups. The young and elderly active men had a significantly better lipoprotein profile and antioxidant status, as well as reduced oxidative damage and inflammatory state. The active young and elderly men had significantly higher plasma BDNF levels compared to their inactive peers. BDNF was correlated with VO2max (r=0.765, P<0.001). In addition, we observed a significant inverse correlation of BDNF with atherogenic index (TC/HDL), hsCRP and oxLDL. The findings demonstrate that a high level of cardiorespiratory fitness reflected in VO2max was associated with a higher level of circulating BDNF, which in turn was related to common CVD risk factors and oxidative damage markers in young and elderly men.
authors.affiliation: University of Zielona Gora, University of Zielona Gora, Department of Applied and Clinical Physiology, Faculty of Medicine and Health Sciences, Zielona Gora , Poland, Department of Applied and Clinical Physiology, Faculty of Medicine and Health Sciences, University of Zielona Gora, Zielona Gora, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Zembron-Lacny
authors.affiliation: University School of Physical Education in Wroclaw, University School of Physical Education in Wroclaw, Department of Physiotherapy in Internal Diseases, Faculty of Physiotherapy, Wroclaw , Poland, Department of Physiotherapy in Internal Diseases, Faculty of Physiotherapy, University School of Physical Education in Wroclaw, Wroclaw, Poland.
authors.forename: W
authors.initials: W
authors.lastname: Dziubek
authors.affiliation: University of Zielona Gora, University of Zielona Gora, Department of Biological Basis of Sport, Faculty of Medicine and Health Sciences, Zielona Gora , Poland, Department of Biological Basis of Sport, Faculty of Medicine and Health Sciences, University of Zielona Gora, Zielona Gora, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Rynkiewicz
authors.affiliation: University of Zielona Gora, University of Zielona Gora, Department of Biological Basis of Sport, Faculty of Medicine and Health Sciences, Zielona Gora , Poland, Department of Biological Basis of Sport, Faculty of Medicine and Health Sciences, University of Zielona Gora, Zielona Gora, Poland.
authors.forename: B
authors.initials: B
authors.lastname: Morawin
authors.affiliation: University School of Physical Education in Wroclaw, University School of Physical Education in Wroclaw, Department of Physiotherapy in Internal Diseases, Faculty of Physiotherapy, Wroclaw , Poland, Department of Physiotherapy in Internal Diseases, Faculty of Physiotherapy, University School of Physical Education in Wroclaw, Wroclaw, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Woźniewski
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D001823:Body Composition / Q000502:physiology; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood* / Q000502:physiology; D002097:C-Reactive Protein / Q000032:analysis; D002318:Cardiovascular Diseases / Q000097:blood* / Q000209:etiology*; D002784:Cholesterol / Q000097:blood; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology; D010101:Oxygen Consumption / Q000502:physiology; D012016:Reference Values; D018570:Risk Assessment; D012307:Risk Factors; D018709:Statistics, Nonparametric; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D015415:Biomarkers; D019208:Brain-Derived Neurotrophic Factor; D014280:Triglycerides; D002097:C-Reactive Protein; D002784:Cholesterol