title: The innate immune signaling in cancer and cardiometabolic diseases: Friends or foes?
abstract: The innate immune system is responsible for sensing pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs) by several types of germline-encoded pattern-recognition receptors (PRRs). It has the capacity to help the human body maintain homeostasis under normal conditions. However, in pathological conditions, PAMPs or DAMPs trigger aberrant innate immune and inflammatory responses and thus negatively or positively influence the progression of cancer and cardiometabolic diseases. Interestingly, we found that some elements of innate immune signaling are involved in these diseases partially via immune-independent manners, indicating a deeper understanding of the function of innate immune signaling in these diseases is urgent. In this review, we summarize the primary innate immune signaling pathways and their association with cancer and cardiometabolic diseases, with the aim of providing effective therapies for these diseases.
authors.affiliation: Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 JieFang Avenue, Wuhan 430022, China.
authors.forename: Weijun
authors.initials: W
authors.lastname: Wang
authors.affiliation: Animal Experiment Center/Animal Biosafety Level-III Laboratory, Wuhan University, Donghu Road 115, Wuhan 430071, China; Department of Cardiology, Renmin Hospital of Wuhan University, Jiefang Road 238, Wuhan 430060, China.
authors.forename: Yaxing
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 JieFang Avenue, Wuhan 430022, China. Electronic address: lingyang70@gmail.com.
authors.forename: Ling
authors.initials: L
authors.lastname: Yang
authors.affiliation: Animal Experiment Center/Animal Biosafety Level-III Laboratory, Wuhan University, Donghu Road 115, Wuhan 430071, China; Department of Cardiology, Renmin Hospital of Wuhan University, Jiefang Road 238, Wuhan 430060, China. Electronic address: lihl@whu.edu.cn.
authors.forename: Hongliang
authors.initials: H
authors.lastname: Li
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D008659:Metabolic Diseases / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology*; D015398:Signal Transduction
keywords: Cancer; Cardiometabolic diseases; Innate immune signaling; PRRs