title: Alpha-synuclein modulates dopamine neurotransmission.
abstract: Alpha-synuclein is a small, highly charged protein encoded by the synuclein or SNCA gene that is predominantly expressed in central nervous system neurons. Although its physiological function remains enigmatic, alpha-synuclein is implicated in movement disorders such as Parkinson's disease, multiple system atrophy, and in neurodegenerative diseases such as Dementia with Lewy bodies. Here we have focused on reviewing the existing literature pertaining to wild-type alpha-synuclein structure, its properties, and its potential involvement in regulation of dopamine neurotransmission.
authors.affiliation: University of Florida, Department of Neuroscience and Department of Psychiatry Gainesville, FL 32611.
authors.forename: Brittany
authors.initials: B
authors.lastname: Butler
authors.affiliation: University of Florida, Department of Neuroscience and Department of Psychiatry Gainesville, FL 32611.
authors.forename: Danielle
authors.initials: D
authors.lastname: Sambo
authors.affiliation: University of Florida, Department of Neuroscience and Department of Psychiatry Gainesville, FL 32611. Electronic address: Habibeh@ufl.edu.
authors.forename: Habibeh
authors.initials: H
authors.lastname: Khoshbouei
mesh_terms: D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D006801:Humans; D009435:Synaptic Transmission / Q000502:physiology*; D051844:alpha-Synuclein / Q000378:metabolism*
chemical_list: D051844:alpha-Synuclein; D004298:Dopamine