title: Negatively Charged Lipid Membranes Catalyze Supramolecular Hydrogel Formation.
abstract: In this contribution we show that biological membranes can catalyze the formation of supramolecular hydrogel networks. Negatively charged lipid membranes can generate a local proton gradient, accelerating the acid-catalyzed formation of hydrazone-based supramolecular gelators near the membrane. Synthetic lipid membranes can be used to tune the physical properties of the resulting multicomponent gels as a function of lipid concentration. Moreover, the catalytic activity of lipid membranes and the formation of gel networks around these supramolecular structures are controlled by the charge and phase behavior of the lipid molecules. Finally, we show that the insights obtained from synthetic membranes can be translated to biological membranes, enabling the formation of gel fibers on living HeLa cells.
authors.affiliation: Department of Chemical Engineering, Delft University of Technology , van der Maasweg, 2629 HZ Delft, The Netherlands.
authors.forename: Frank
authors.initials: F
authors.lastname: Versluis
authors.affiliation: Leiden Institute of Chemistry, Leiden University , P.O. Box 9502, 2300 RA Leiden, The Netherlands.
authors.forename: Daphne M
authors.initials: DM
authors.lastname: van Elsland
authors.affiliation: Department of Chemical Engineering, Delft University of Technology , van der Maasweg, 2629 HZ Delft, The Netherlands.
authors.forename: Serhii
authors.initials: S
authors.lastname: Mytnyk
authors.affiliation: Department of Chemical Engineering, Delft University of Technology , van der Maasweg, 2629 HZ Delft, The Netherlands.
authors.forename: Dayinta L
authors.initials: DL
authors.lastname: Perrier
authors.affiliation: Department of Chemical Engineering, Delft University of Technology , van der Maasweg, 2629 HZ Delft, The Netherlands.
authors.forename: Fanny
authors.initials: F
authors.lastname: Trausel
authors.affiliation: Department of Chemical Engineering, Delft University of Technology , van der Maasweg, 2629 HZ Delft, The Netherlands.
authors.forename: Jos M
authors.initials: JM
authors.lastname: Poolman
authors.affiliation: Department of Chemical Engineering, Delft University of Technology , van der Maasweg, 2629 HZ Delft, The Netherlands.
authors.forename: Chandan
authors.initials: C
authors.lastname: Maity
authors.affiliation: Department of Chemical Engineering, Delft University of Technology , van der Maasweg, 2629 HZ Delft, The Netherlands.
authors.forename: Vincent A A
authors.initials: VA
authors.lastname: le Sage
authors.affiliation: Leiden Institute of Chemistry, Leiden University , P.O. Box 9502, 2300 RA Leiden, The Netherlands.
authors.forename: Sander I
authors.initials: SI
authors.lastname: van Kasteren
authors.affiliation: Department of Chemical Engineering, Delft University of Technology , van der Maasweg, 2629 HZ Delft, The Netherlands.
authors.forename: Jan H
authors.initials: JH
authors.lastname: van Esch
authors.affiliation: Department of Chemical Engineering, Delft University of Technology , van der Maasweg, 2629 HZ Delft, The Netherlands.
authors.forename: Rienk
authors.initials: R
authors.lastname: Eelkema
mesh_terms: D002384:Catalysis; D002462:Cell Membrane / Q000737:chemistry* / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D010715:Phosphatidylglycerols / Q000737:chemistry / Q000378:metabolism
chemical_list: D010715:Phosphatidylglycerols; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; C051388:1,2-dioleoyl-sn-glycero-3-phosphoglycerol; C030345:1,2-dipalmitoylphosphatidylglycerol