title: Human absorbed dose estimation for a new (175)Yb-phosphonate based on rats data: Comparison with similar bone pain palliation agents.
abstract: In this work, the absorbed dose to human organs for (175)Yb-BPAMD was evaluated based on the biodistribution studies in rats. The results showed that the bone surface would receive the highest absorbed dose after injection of (175)Yb-BPAMD with 13.32mGy/MBq, while the other organs receive insignificant absorbed dose. Also, the comparison of (175)Yb-BPAMD with other therapeutic phosphonate complexes demonstrated noticeable characteristics for this new agent. Generally, based on the obtained results, (175)Yb-BPAMD can be considered as a promising agent for bone pain palliative therapy in near future.
authors.affiliation: Energy Engineering and Department of Physics, Amir Kabir University of Technology, Tehran, Iran.
authors.forename: Mahdokht
authors.initials: M
authors.lastname: Vaez-Tehrani
authors.affiliation: Nuclear Science and Technology Research Institute (NSTRI), 14155-1339 Tehran, Iran.
authors.forename: Samaneh
authors.initials: S
authors.lastname: Zolghadri
authors.affiliation: Nuclear Science and Technology Research Institute (NSTRI), 14155-1339 Tehran, Iran.
authors.forename: Hassan
authors.initials: H
authors.lastname: Yousefnia
authors.affiliation: Energy Engineering and Department of Physics, Amir Kabir University of Technology, Tehran, Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Afarideh
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000150:complications; D006801:Humans; D063065:Organophosphonates / Q000493:pharmacokinetics*; D010146:Pain / Q000188:drug therapy*; D059408:Pain Management; D011829:Radiation Dosage; D051381:Rats; D014018:Tissue Distribution; D015018:Ytterbium
chemical_list: D063065:Organophosphonates; D015018:Ytterbium
keywords: Absorbed dose; BPAMD; RADAR; Ytterbium-175