title: A pilot comparative study of topical latanoprost and tacrolimus in combination with narrow-band ultraviolet B phototherapy and microneedling for the treatment of nonsegmental vitiligo.
abstract: Prostaglandins and their analogues are beneficial as topical agents in vitiligo treatment, yet neither of the previous study addressed their comparative efficiency with conventional topical agents used in vitiligo treatment. In this pilot (24 patients) left-right comparative study we addressed efficiency of prostaglandin F2α analogue latanoprost versus tacrolimus when combined with narrow-band ultraviolet B and microneedling in repigmentation of nonsegmental vitiligo lesions. Our results confirm potency of prostaglandins, in particular, that of latanoprost, in inducing repigmentation, with the efficiency being at least comparable to that of tacrolimus, while contribution of microneedling remains unclear. In summary, results of our study provide further evidences for justified use of prostaglandins, in particular, latanoprost, in vitiligo treatment. In turn, this warrants future studies on the topic aiming to conclusively introduce prostaglandin-based formulations as conventional agents for vitiligo management.
authors.affiliation: VR Foundation, New York, New York, USA.
authors.forename: Igor V
authors.initials: IV
authors.lastname: Korobko
authors.affiliation: Department of Skin and Venereal Diseases, Therapeutic Faculty, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
authors.forename: Konstantin M
authors.initials: KM
authors.lastname: Lomonosov
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D003357:Cosmetic Techniques / Q000009:adverse effects / Q000295:instrumentation*; D003879:Dermatologic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D004867:Equipment Design; D005260:Female; D006801:Humans; D000077338:Latanoprost; D008297:Male; D008875:Middle Aged; D008904:Miniaturization; D009339:Needles; D010865:Pilot Projects; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage* / Q000009:adverse effects; D012880:Skin Pigmentation / Q000187:drug effects* / Q000528:radiation effects*; D016559:Tacrolimus / Q000008:administration & dosage* / Q000009:adverse effects; D013997:Time Factors; D016896:Treatment Outcome; D014467:Ultraviolet Therapy / Q000009:adverse effects; D014820:Vitiligo / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D055815:Young Adult
chemical_list: D003879:Dermatologic Agents; D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost; D016559:Tacrolimus
keywords: comparative study; latanoprost; microneedling; narrow-band ultraviolet B; nonsegmental vitiligo; prostaglandins; repigmentation; tacrolimus