title: Circulating MicroRNA-21 is Downregulated in Patients with Metabolic Syndrome.
abstract: The microRNA-21 (miR-21) is known to play a major role in cancer progression; however, its function in the cardiovascular system appears to be even more complex and conflicting. To characterize miR-21 expression in the plasma of individuals with or without metabolic syndrome (MetS), 58 MetS cases and 96 non-MetS controls were investigated. Expression levels of miR-21 were significantly decreased in the circulation of MetS subjects (OR=0.52, 95% CI: 0.29-0.92) compared with that of non-MetS subjects. Body mass index (BMI) and the number of MetS components had a negative correlation with the level of miR-21, whereas age was inversely related to the level of miR-21. No significant difference was detected in miR-21 levels between the sexes (P=0.056). MiR-21 might be a negative regulating factor in MetS.
authors.affiliation: Zhejiang Provincial Center for Disease Prevention and Control, Hangzhou 310051, Zhejiang, China.
authors.forename: Qing Fang
authors.initials: QF
authors.lastname: He
authors.affiliation: Zhejiang Provincial Center for Disease Prevention and Control, Hangzhou 310051, Zhejiang, China.
authors.forename: Li Xin
authors.initials: LX
authors.lastname: Wang
authors.affiliation: Zhejiang Provincial Center for Disease Prevention and Control, Hangzhou 310051, Zhejiang, China.
authors.forename: Jie Ming
authors.initials: JM
authors.lastname: Zhong
authors.affiliation: Zhejiang Provincial Center for Disease Prevention and Control, Hangzhou 310051, Zhejiang, China.
authors.forename: Ru Ying
authors.initials: RY
authors.lastname: Hu
authors.affiliation: Zhejiang Provincial Center for Disease Prevention and Control, Hangzhou 310051, Zhejiang, China.
authors.forename: Le
authors.initials: L
authors.lastname: Fang
authors.affiliation: Zhejiang Provincial Center for Disease Prevention and Control, Hangzhou 310051, Zhejiang, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Zhejiang Provincial Center for Disease Prevention and Control, Hangzhou 310051, Zhejiang, China.
authors.forename: Wei Wei
authors.initials: WW
authors.lastname: Gong
authors.affiliation: Zhejiang Provincial Center for Disease Prevention and Control, Hangzhou 310051, Zhejiang, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Zhejiang Provincial Center for Disease Prevention and Control, Hangzhou 310051, Zhejiang, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Pan
authors.affiliation: Zhejiang Provincial Center for Disease Prevention and Control, Hangzhou 310051, Zhejiang, China.
authors.forename: Min
authors.initials: M
authors.lastname: Yu
mesh_terms: D000328:Adult; D000368:Aged; D015536:Down-Regulation; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000209:etiology / Q000235:genetics*; D035683:MicroRNAs / Q000097:blood / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012307:Risk Factors
chemical_list: C524940:MIRN21 microRNA, human; D035683:MicroRNAs