title: Long-term effects of weight reduction on the severity of psoriasis in a cohort derived from a randomized trial: a prospective observational follow-up study.
abstract: BACKGROUND
  Weight reduction may reduce the severity of psoriasis, but little is known about the long-term effects.
  
  
  OBJECTIVE
  We aimed to investigate long-term effects of weight reduction in psoriasis.
  
  
  METHODS
  We previously conducted a randomized trial (n = 60) involving patients with psoriasis who were allocated to a control group or a low-energy diet (LED) group. Here we followed the participants for an additional 48-wk period. In total, 56 patients with psoriasis [mean ± SD body mass index (in kg/m(2)): 34.4 ± 5.3] underwent a 64-wk weight-loss program consisting of an initial 16-wk randomized phase with an LED for 8 wk and 8 wk of normal food intake combined with 2 LED products/d, followed by a 48-wk period of weight maintenance with the latter diet. After the randomization phase, the control group received the same 8 + 8-wk LED intervention, and all patients were then followed for 48 wk while on the weight-loss maintenance diet. The main outcome was the Psoriasis Area and Severity Index (PASI), and secondary outcome was the Dermatology Life Quality Index (DLQI).
  
  
  RESULTS
  For the present study, 56 patients were eligible, 38 agreed to participate, and 32 completed. After the 16-wk LED-only period, the mean weight loss was -15.0 kg (95% CI: -16.6, -13.4 kg), and PASI and DLQI were reduced by -2.3 (95% CI: -3.1, -1.5) and -2.3 (95% CI: -3.2, -1.4), respectively. At week 64, the mean weight loss compared with baseline was -10.1 kg (95% CI: -12.0, -8.1 kg), and PASI and DLQI were maintained at -2.9 (95% CI: -3.9, -1.9) and -1.9 (95% CI: -3.0, -0.9), respectively.
  
  
  CONCLUSIONS
  Long-term weight loss in patients with psoriasis has long-lasting positive effects on the severity of psoriasis. This trial was registered at clinicaltrials.gov as NCT01137188.
authors.affiliation: Departments of Dermato-Allergology, peter.jensen@regionh.dk.
authors.forename: Peter
authors.initials: P
authors.lastname: Jensen
authors.affiliation: Musculoskeletal Statistics Unit, Parker Institute, Department of Rheumatology, Frederiksberg Hospital and.
authors.forename: Robin
authors.initials: R
authors.lastname: Christensen
authors.affiliation: Departments of Dermato-Allergology.
authors.forename: Claus
authors.initials: C
authors.lastname: Zachariae
authors.affiliation: Nutrition Research Unit, Herlev Hospital, University of Copenhagen, Herlev, Denmark.
authors.forename: Nina Rw
authors.initials: NR
authors.lastname: Geiker
authors.affiliation: Clinical Physiology and Nuclear Medicine.
authors.forename: Bente K
authors.initials: BK
authors.lastname: Schaadt
authors.affiliation: Clinical Biochemistry, and.
authors.forename: Steen
authors.initials: S
authors.lastname: Stender
authors.affiliation: Cardiology, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark;
authors.forename: Peter R
authors.initials: PR
authors.lastname: Hansen
authors.affiliation: Department of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark; and.
authors.forename: Arne
authors.initials: A
authors.lastname: Astrup
authors.affiliation: Departments of Dermato-Allergology.
authors.forename: Lone
authors.initials: L
authors.lastname: Skov
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015992:Body Mass Index; D031204:Caloric Restriction; D004038:Diet, Reducing; D002149:Energy Intake; D005500:Follow-Up Studies; D009765:Obesity / Q000150:complications / Q000178:diet therapy; D011446:Prospective Studies; D011565:Psoriasis / Q000150:complications; D011788:Quality of Life; D012720:Severity of Illness Index; D012867:Skin / Q000473:pathology; D015431:Weight Loss / Q000502:physiology; D061217:Weight Reduction Programs; D016032:Randomized Controlled Trials as Topic
keywords: inflammation; long-term weight maintenance; obesity; psoriasis; weight reduction