title: Prognostic significance of PLIN1 expression in human breast cancer.
abstract: Breast cancer is a heterogeneous disease associated with diverse clinical, biological and molecular features, presenting huge challenges for prognosis and treatment. Here we found that perilipin-1 (PLIN1) mRNA expression is significantly downregulated in human breast cancer. Kaplan-Meier analysis indicated that patients presenting with reduced PLIN1 expression exhibited poorer overall metastatic relapse-free survival (p = 0.03). Further Cox proportional hazard models analysis revealed that the reduced expression of PLIN1 is an independent predictor of overall survival in estrogen receptor positive (p < 0.0001, HR = 0.87, 95% CI = 0.81-0.92, N = 3,600) and luminal A-subtype (p = 0.02, HR = 0.88, 95% CI = 0.78-0.98, N = 1,469) breast cancer patients. We also demonstrated that the exogenous expression of PLIN1 in human breast cancer MCF-7 and MDA-MB-231 cells significantly inhibits cell proliferation, migration, invasion and in vivo tumorigenesis in mice. Together, these data provide novel insights into a prognostic significance of PLIN1 in human breast cancer and reveal a potentially new gene therapy target for breast cancer.
authors.affiliation: Institute of Biomedical and Pharmaceutical Sciences, and Provincial Cooperative Innovation Center, College of Bioengineering, Hubei University of Technology, Wuhan, Hubei, China.|The State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei, China.
authors.forename: Cefan
authors.initials: C
authors.lastname: Zhou
authors.affiliation: Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Wang
authors.affiliation: Animal Biosafety Level III Laboratory at the Center for Animal Experiment, Wuhan University, Wuhan, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Institute of Biomedical and Pharmaceutical Sciences, and Provincial Cooperative Innovation Center, College of Bioengineering, Hubei University of Technology, Wuhan, Hubei, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Clinical Laboratory, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.
authors.forename: Weiyong
authors.initials: W
authors.lastname: Liu
authors.affiliation: Institute of Biomedical and Pharmaceutical Sciences, and Provincial Cooperative Innovation Center, College of Bioengineering, Hubei University of Technology, Wuhan, Hubei, China.
authors.forename: Wenying
authors.initials: W
authors.lastname: Qin
authors.affiliation: Institute of Biomedical and Pharmaceutical Sciences, and Provincial Cooperative Innovation Center, College of Bioengineering, Hubei University of Technology, Wuhan, Hubei, China.
authors.forename: Rong
authors.initials: R
authors.lastname: He
authors.affiliation: Institute of Biomedical and Pharmaceutical Sciences, and Provincial Cooperative Innovation Center, College of Bioengineering, Hubei University of Technology, Wuhan, Hubei, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Lu
authors.affiliation: The State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei, China.
authors.forename: Yefu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Institute of Biomedical and Pharmaceutical Sciences, and Provincial Cooperative Innovation Center, College of Bioengineering, Hubei University of Technology, Wuhan, Hubei, China.|Membrane Protein Disease Research Group, Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
authors.forename: Xing-Zhen
authors.initials: XZ
authors.lastname: Chen
authors.affiliation: Institute of Biomedical and Pharmaceutical Sciences, and Provincial Cooperative Innovation Center, College of Bioengineering, Hubei University of Technology, Wuhan, Hubei, China.
authors.forename: Jingfeng
authors.initials: J
authors.lastname: Tang
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000737:chemistry / Q000401:mortality* / Q000473:pathology; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D005260:Female; D016158:Genes, p53; D006801:Humans; D051379:Mice; D009154:Mutation; D009361:Neoplasm Invasiveness; D000070778:Perilipin-1 / Q000032:analysis*; D011379:Prognosis; D016016:Proportional Hazards Models; D011960:Receptors, Estrogen / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; C000602978:PLIN1 protein, human; D000070778:Perilipin-1; D011960:Receptors, Estrogen
keywords: Kaplan-Meier analysis; biomarker; meta analysis; perilipin-1; tumor suppressor