title: Developmental Origins of Hypoxic Pulmonary Hypertension and Systemic Vascular Dysfunction: Evidence from Humans.
abstract: Epidemiological studies have shown an association between pathologic events occurring during fetal/perinatal life and the development of cardiovascular and metabolic disease in adulthood. These observations have led to the so-called developmental origin of adult disease hypothesis. More recently, evidence has been provided that the pulmonary circulation is also an important target for the developmental programming of adult disease in both experimental animal models and in humans. Here we will review this evidence and provide insight into mechanisms that may play a pathogenic role.
authors.affiliation: Department of Internal Medicine, University Hospital, Lausanne, Switzerland. claudio.sartori@chuv.ch.
authors.forename: Claudio
authors.initials: C
authors.lastname: Sartori
authors.affiliation: Department of Cardiology, Swiss Cardiovascular Center Bern, University Hospital, Bern, Switzerland.
authors.forename: Stefano F
authors.initials: SF
authors.lastname: Rimoldi
authors.affiliation: Department of Internal Medicine, University Hospital, Lausanne, Switzerland.
authors.forename: Hervé
authors.initials: H
authors.lastname: Duplain
authors.affiliation: Imperial College Healthcare NHS Trust, St. Mary's Hospital, London, UK.
authors.forename: Thomas
authors.initials: T
authors.lastname: Stuber
authors.affiliation: Department of Internal Medicine, University Hospital, Lausanne, Switzerland.
authors.forename: Sophie
authors.initials: S
authors.lastname: Garcin
authors.affiliation: Department of Cardiology, Swiss Cardiovascular Center Bern, University Hospital, Bern, Switzerland.
authors.forename: Emrush
authors.initials: E
authors.lastname: Rexhaj
authors.affiliation: Department of Cardiology, Swiss Cardiovascular Center Bern, University Hospital, Bern, Switzerland.
authors.forename: Yves
authors.initials: Y
authors.lastname: Allemann
authors.affiliation: Department of Cardiology, Swiss Cardiovascular Center Bern, University Hospital, Bern, Switzerland.|Departamento de Biología, Universidad de Tarapacá, Arica, Chile.
authors.forename: Urs
authors.initials: U
authors.lastname: Scherrer
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000196:embryology* / Q000503:physiopathology*; D004777:Environment; D047109:Fetal Development; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications* / Q000503:physiopathology*; D000860:Hypoxia / Q000150:complications* / Q000503:physiopathology*; D008954:Models, Biological
keywords: Barker hypothesis; Epigenetics; Perinatal insult