title: Alzheimer's disease: the silver tsunami of the 21(st) century.
abstract: Alzheimer's disease (AD), a fatal progressive neurodegenerative disorder, has no cure to date. One of the causes of AD is the accumulation of amyloid-beta 42 (Aβ42) plaques, which result in the onset of neurodegeneration. It is not known how these plaques trigger the onset of neurodegeneration. There are several animal models developed to (i) study etiology of disease, (ii) look for genetic modifiers, and (iii) identify chemical inhibitors that can block neurodegeneration and help to find cure for this disease. An insect model of Drosophila melanogaster has also provided new insights into the disease. Here we will discuss the utility of the Drosophila eye model to study Alzheimer's disease.
authors.affiliation: Department of Biology, University of Dayton, Dayton, OH, USA.
authors.forename: Ankita
authors.initials: A
authors.lastname: Sarkar
authors.affiliation: Department of Biology, University of Dayton, Dayton, OH, USA.
authors.forename: Madison
authors.initials: M
authors.lastname: Irwin
authors.affiliation: Department of Biology, University of Dayton, Dayton, OH, USA.
authors.forename: Aditi
authors.initials: A
authors.lastname: Singh
authors.affiliation: Department of Biology, University of Dayton, Dayton, OH, USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: Riccetti
authors.affiliation: Department of Biology, University of Dayton, Dayton, OH, USA; Premedical Program, University of Dayton, Dayton, OH, USA; Center for Tissue Regeneration and Engineering at Dayton (TREND), University of Dayton, Dayton, OH, USA.
authors.forename: Amit
authors.identifier: 0000-0002-2962-2255
authors.initials: A
authors.lastname: Singh
keywords: Alzheimer's disease; amyloid hypothesis; amyloid plaques; animal models; drosophila eye; drosophila melanogaster; neurodegeneration