title: Catalytic Asymmetric [4 + 1] Annulation of Sulfur Ylides with Copper-Allenylidene Intermediates.
abstract: The first copper-catalyzed asymmetric decarboxylative [4 + 1] cycloaddition of propargylic carbamates and sulfur ylides was successfully developed. This strategy led to a series of chiral indolines with synthetically flexible alkyne groups in good yields and with high enantio- and diastereoselectivities (up to 99% yield, 98% ee, and >95:5 dr). A possible mechanism and stereoinduction mode with copper-allenylidenes were proposed as the possible dipolar intermediate.
authors.affiliation: College of Chemistry, Central China Normal University , 152 Luoyu Road, Wuhan, Hubei 430079, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wang
authors.affiliation: College of Chemistry, Central China Normal University , 152 Luoyu Road, Wuhan, Hubei 430079, China.
authors.forename: Tian-Ren
authors.initials: TR
authors.lastname: Li
authors.affiliation: College of Chemistry, Central China Normal University , 152 Luoyu Road, Wuhan, Hubei 430079, China.
authors.forename: Liang-Qiu
authors.initials: LQ
authors.lastname: Lu
authors.affiliation: College of Chemistry, Central China Normal University , 152 Luoyu Road, Wuhan, Hubei 430079, China.
authors.forename: Miao-Miao
authors.initials: MM
authors.lastname: Li
authors.affiliation: College of Chemistry, Central China Normal University , 152 Luoyu Road, Wuhan, Hubei 430079, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Zhang
authors.affiliation: College of Chemistry, Central China Normal University , 152 Luoyu Road, Wuhan, Hubei 430079, China.|State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou, Gansu 730000, China.
authors.forename: Wen-Jing
authors.initials: WJ
authors.lastname: Xiao