title: Vaccination in Multiple Myeloma: Review of Current Literature.
abstract: Multiple myeloma is a cancer of the immune system. Infection is a major cause of morbidity and mortality in patients with multiple myeloma. Some of these infections are preventable by vaccines available to the general population. However, little is known about the clinical effectiveness of these vaccines in patients with multiple myeloma, and the cellular and humoral immune response to vaccination has not been well characterized, especially in conjunction with modern myeloma therapies. The present report reviews the basics of multiple myeloma and the immune system, the available evidence on the immunologic response of patients with multiple myeloma after vaccination, and current practice recommendations regarding specific vaccines. Understanding the immune response to vaccines could help us understand how immuno-oncology-based therapies work in multiple myeloma and provide future directions for research.
authors.affiliation: Aurora Research Institute, Aurora Health Care, Milwaukee, WI.
authors.forename: Andinet
authors.initials: A
authors.lastname: Alemu
authors.affiliation: Aurora Research Institute, Aurora Health Care, Milwaukee, WI.
authors.forename: John O
authors.initials: JO
authors.lastname: Richards
authors.affiliation: Transplant Research Laboratory, Aurora St. Luke's Medical Center, Aurora Health Care, Milwaukee, WI.
authors.forename: Martin K
authors.initials: MK
authors.lastname: Oaks
authors.affiliation: Aurora Research Institute, Aurora Health Care, Milwaukee, WI. Electronic address: Michael.A.Thompson@aurora.org.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Thompson
mesh_terms: D001428:Bacterial Vaccines / Q000276:immunology; D003131:Combined Modality Therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D017053:Infection Control / Q000379:methods; D007239:Infections / Q000209:etiology*; D009101:Multiple Myeloma / Q000150:complications* / Q000276:immunology* / Q000628:therapy; D000072737:Myeloid-Derived Suppressor Cells / Q000276:immunology / Q000378:metabolism; D017063:Outcome Assessment, Health Care; D014611:Vaccination / Q000379:methods; D014612:Vaccines / Q000008:administration & dosage / Q000276:immunology*; D014765:Viral Vaccines / Q000276:immunology
chemical_list: D001428:Bacterial Vaccines; D007166:Immunosuppressive Agents; D014612:Vaccines; D014765:Viral Vaccines
keywords: Immune system; Influenza; Multiple myeloma; Pneumonia; Supportive care