title: Skin tumours and skin aging in 209 French elderly people: the PROOF study.
abstract: Few studies have evaluated the prevalence of skin tumours in the geriatric population and none have analysed different skin aging parameters for whole-body skin in this population. To evaluate the prevalence of skin tumours and global skin aging in a French cohort of elderly people. In total, 209 subjects, 105 women and 104 men (mean age: 77.5; range: 74-81 years), were enrolled from the PROOF (PROgnostic indicator OF cardiovascular and cerebrovascular events) cohort. SCINEXA (SCore for INtrinsic and EXtrinsic skin Aging) was used to assess the degree of skin aging and the prevalence of skin tumours. Some additional cutaneous parameters were also studied. Skin aging in women and men was compared. Mean global SCINEXA was 24.3 (SD: 4.7; range: 8.2-35.3). Solar elastosis and lax appearance were more severe in women (t test; p<0.0001), whereas pseudoscars (t test; p = 0.0312) and coarse wrinkles (t test; p = 0.0479) were more severe in men. Erythrosis coli (chi-square test; p <0.0001) was more frequent in men, whereas varicous veins (chi-square test; p = 0.0026) and eyelid xanthomas (chi-square test; p = 0.0282) were more frequent in women. Twelve patients presented with cutaneous carcinomas and two patients had early melanomas. This research describes in detail the main indices of skin aging in an old population and the differences related to gender. Moreover, it highlights the utility of systematic screening of old patients by dermatologists in order to diagnose skin cancers early.
authors.affiliation: Department of Dermatology, University Hospital of Saint Etienne, Cedex 2, 42055 Saint Etienne, France.
authors.forename: Elisa
authors.initials: E
authors.lastname: Cinotti
authors.affiliation: Department of Dermatology, University Hospital of Saint Etienne, Cedex 2, 42055 Saint Etienne, France.
authors.forename: Jean Luc
authors.initials: JL
authors.lastname: Perrot
authors.affiliation: Department of Dermatology, University Hospital of Saint Etienne, Cedex 2, 42055 Saint Etienne, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Labeille
authors.affiliation: Department of Dermatology, University Hospital of Saint Etienne, Cedex 2, 42055 Saint Etienne, France.
authors.forename: Anne Catherine
authors.initials: AC
authors.lastname: Biron
authors.affiliation: IUF, Leibniz Research Institute for Environmental Medicine, Auf'm Hennekamp 50, D-40225 Düsseldorf, Germany.
authors.forename: Andrea
authors.initials: A
authors.lastname: Vierkötter
authors.affiliation: LVMH Research, 185 Avenue de Verdun, Saint Jean-de-Braye 45804.
authors.forename: Catherine
authors.initials: C
authors.lastname: Heusèle
authors.affiliation: LVMH Research, 185 Avenue de Verdun, Saint Jean-de-Braye 45804.
authors.forename: Carine
authors.initials: C
authors.lastname: Nizard
authors.affiliation: LVMH Research, 185 Avenue de Verdun, Saint Jean-de-Braye 45804.
authors.forename: Sylvianne
authors.initials: S
authors.lastname: Schnebert
authors.affiliation: Clinical and Exercise Physiology Laboratory, University Hospital of Saint Etienne, Cedex 2, 42055 Saint Etienne, France.
authors.forename: Jean Claude
authors.initials: JC
authors.lastname: Barthelemy
authors.affiliation: Department of Dermatology, University Hospital of Saint Etienne, Cedex 2, 42055 Saint Etienne, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Cambazard
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002280:Basal Cell Carcinoma / Q000453:epidemiology*; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology*; D003872:Dermatitis / Q000453:epidemiology; D005141:Eyelid Diseases / Q000453:epidemiology; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008297:Male; D008545:Melanoma / Q000453:epidemiology*; D011230:Precancerous Conditions / Q000453:epidemiology*; D015995:Prevalence; D012737:Sex Factors; D015595:Skin Aging; D012878:Skin Neoplasms / Q000453:epidemiology*; D014648:Varicose Veins / Q000453:epidemiology; D014973:Xanthomatosis / Q000453:epidemiology
keywords: SCINEXA; aging; elderly people; melanoma; prevalence; skin; tumor