title: A case of hemifacial paresis in a patient with Lyme neuroborreliosis treated with antibiotics in whom Borrelia meningitis developed.
abstract: A 38-year-old man visited our hospital because of hemifacial paresis that developed 2 months after being bit by a tick. We diagnosed idiopathic peripheral facial palsy and gave the patient oral prednisolone and valacyclovir. Although the symptoms completely resolved in about 2 weeks, there was a risk of Lyme neuroborreliosis. The patient therefore received doxycycline (100 mg twice daily) and amoxicillin (1,000 mg 3 times daily) for 14 days. Two months later, he had symptoms of meningitis such as headache and fever accompanied by lymphocytic cerebrospinal fluid pleocytosis. Viral meningitis was diagnosed and treated with parenteral acyclovir. The symptoms of meningitis improved. Tests for serum IgG antibodies against borrelia were positive. We gave the patient a diagnosis of Lyme neuroborreliosis. The patient received intravenous ceftriaxone and had no relapse. It is a rare for meningitis to develop in a patient with cranial neuropathy who received doxycycline. Lyme neuroborreliosis is a rare disease in Japan. Care should therefore be exercised in the diagnosis of Lyme neuroborreliosis and evaluation of the response to treatment.
authors.affiliation: Department of Neurology, Nara City Hospital.
authors.forename: Hisao
authors.initials: H
authors.lastname: Shimizu
authors.forename: Koji
authors.initials: K
authors.lastname: Haratani
authors.forename: Masayuki
authors.initials: M
authors.lastname: Miyazaki
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kakehi
authors.forename: Shuhei
authors.initials: S
authors.lastname: Nagami
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Katanami
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kawabata
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Takahashi
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D000907:Antibodies, Bacterial / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001898:Borrelia / Q000276:immunology; D001899:Borrelia Infections; D002443:Ceftriaxone / Q000008:administration & dosage; D004318:Doxycycline / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005158:Facial Paralysis / Q000209:etiology; D006801:Humans; D020852:Lyme Neuroborreliosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D016920:Meningitis, Bacterial / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology* / Q000382:microbiology*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial; D015415:Biomarkers; D002443:Ceftriaxone; D004318:Doxycycline