title: Knowledge-base for interpretation of cerebrospinal fluid data patterns. Essentials in neurology and psychiatry.
abstract: The physiological and biophysical knowledge base for interpretations of cerebrospinal fluid (CSF) data and reference ranges are essential for the clinical pathologist and neurochemist. With the popular description of the CSF flow dependent barrier function, the dynamics and concentration gradients of blood-derived, brain-derived and leptomeningeal proteins in CSF or the specificity-independent functions of B-lymphocytes in brain also the neurologist, psychiatrist, neurosurgeon as well as the neuropharmacologist may find essentials for diagnosis, research or development of therapies. This review may help to replace the outdated ideas like "leakage" models of the barriers, linear immunoglobulin Index Interpretations or CSF electrophoresis. Calculations, Interpretations and analytical pitfalls are described for albumin quotients, quantitation of immunoglobulin synthesis in Reibergrams, oligoclonal IgG, IgM analysis, the polyspecific ( MRZ- ) antibody reaction, the statistical treatment of CSF data and general quality assessment in the CSF laboratory. The diagnostic relevance is documented in an accompaning review.
authors.affiliation: CSF and Complexity Studies, Sao Paulo SP , Brasil, CSF and Complexity Studies, Sao Paulo SP, Brasil;|Georg-August-Universität Göttingen, University Goettingen, Former Neurochemistry Laboratory, Goettingen , Germany, University Goettingen, Former Neurochemistry Laboratory, Goettingen, Germany.
authors.forename: Hansotto
authors.initials: H
authors.lastname: Reiber
mesh_terms: D015415:Biomarkers / Q000134:cerebrospinal fluid; D002555:Cerebrospinal Fluid / Q000378:metabolism*; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis*; D006801:Humans; D051188:Knowledge Bases; D001523:Mental Disorders / Q000134:cerebrospinal fluid*; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid*; D012016:Reference Values
chemical_list: D015415:Biomarkers; D002556:Cerebrospinal Fluid Proteins