title: A propitious time for initiating clinical trials in patients with heart failure with reduced ejection fraction and an estimated glomerular filtration rate <30 mL/min with an mineralocorticoid receptor antagonist and a K+ binder: 'the forbidden fruit'.
authors.affiliation: Division of Nephrology and Hypertension, University of Miami Miller School of Medicine, PO Box 016960 (R-126), Miami, FL 33101, USA murraye@gate.net.
authors.forename: Murray
authors.initials: M
authors.lastname: Epstein
authors.affiliation: Division of Cardiology, University of Michigan School of Medicine, Ann Arbor, MI, USA.
authors.forename: Bertram C
authors.initials: BC
authors.lastname: Pitt
mesh_terms: D005919:Glomerular Filtration Rate / Q000502:physiology*; D006333:Heart Failure / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology / Q000503:physiopathology; D006801:Humans; D000451:Mineralocorticoid Receptor Antagonists / Q000627:therapeutic use*; D008991:Monitoring, Physiologic; D018579:Patient Selection; D016032:Randomized Controlled Trials as Topic; D051436:Renal Insufficiency, Chronic / Q000150:complications* / Q000188:drug therapy* / Q000453:epidemiology / Q000503:physiopathology; D013318:Stroke Volume / Q000502:physiology*
chemical_list: D000451:Mineralocorticoid Receptor Antagonists