title: Impact of caesarean section on mode of delivery, pregnancy-induced and pregnancy-associated disorders, and complications in the subsequent pregnancy in Germany.
abstract: OBJECTIVE
  To analyze the impact of caesarean section (CS) on mode of delivery, pregnancy-induced and pregnancy-associated disorders, as well as complications in the subsequent pregnancy within German gynecological practices.
  
  
  METHODS
  1,801 women with CS and 1,801 matched women with vaginal delivery (VD) from the IMS Disease Analyzer database were included. The impact of previous CS on the mode of delivery and pregnancy-associated disorders as well as complications prior to or during birth in the subsequent pregnancy were analyzed. Cox regressions were used to determine the influence of CS with regard to these outcomes.
  
  
  RESULTS
  Medical abortion and single spontaneous delivery were significantly less frequent in women with a history of CS compared to VD (OR equal to 0.52 and 0.04 respectively), whereas CS after CS was the significantly more common mode of delivery (79.0% versus 9.3%, OR=36.47). Gestational hypertension without significant proteinuria, gestational hypertension with significant proteinuria, and polyhydramnios were more frequent in women with CS than in women with VD (OR equal to 6.80, 1.71, and 2.29). Hemorrhage and maternal care for known or suspected disproportion were more common in the CS group than in the VD group (OR equal to 1.34 and 3.75). Prolonged pregnancy, preterm labor, abnormalities arising from forces of labor, and perineal laceration during delivery were significantly less frequent in women with CS than in women with VD (OR between 0.32 and 0.75), whereas long labor was more common (OR=2.09).
  
  
  CONCLUSIONS
  Women with CS were more likely to undergo further CS and to develop major pregnancy-associated diseases in the following pregnancy compared to women with VD.
authors.affiliation: Department of Biology, École Normale Supérieure de Lyon, Lyon, France.
authors.forename: Louis
authors.initials: L
authors.lastname: Jacob
authors.affiliation: Department of Gynecological Endocrinology and Reproductive Medicine, Hospital of Gynecology and Obstetrics University, Hospital Gießen und Marburg, Marburg (Lahn), Germany.
authors.forename: Sevil
authors.initials: S
authors.lastname: Taskan
authors.affiliation: Department of Obstetrics and Gynecology, Helsinki University and Helsinki University Central Hospital, Helsinki, Finland.
authors.forename: George
authors.initials: G
authors.lastname: Macharey
authors.affiliation: Department of Gynecological Endocrinology and Reproductive Medicine, Hospital of Gynecology and Obstetrics University, Hospital Gießen und Marburg, Marburg (Lahn), Germany.
authors.forename: Ingeborg
authors.initials: I
authors.lastname: Sechet
authors.affiliation: Department of Gynecological Endocrinology and Reproductive Medicine, Hospital of Gynecology and Obstetrics University, Hospital Gießen und Marburg, Marburg (Lahn), Germany.
authors.forename: Volker
authors.initials: V
authors.lastname: Ziller
authors.affiliation: IMS Health, Frankfurt, Germany.
authors.forename: Karel
authors.initials: K
authors.lastname: Kostev
mesh_terms: D000028:Abortion, Induced / Q000706:statistics & numerical data; D001720:Birth Injuries / Q000453:epidemiology; D016022:Case-Control Studies; D052178:Cephalopelvic Disproportion / Q000453:epidemiology; D002585:Cesarean Section / Q000706:statistics & numerical data*; D036861:Delivery, Obstetric / Q000706:statistics & numerical data; D004420:Dystocia / Q000453:epidemiology; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000453:epidemiology; D007233:Infant, Postmature; D022125:Lacerations / Q000453:epidemiology; D007752:Obstetric Labor, Premature / Q000453:epidemiology; D010502:Perineum / Q000293:injuries; D006831:Polyhydramnios / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D014592:Uterine Hemorrhage / Q000453:epidemiology*
keywords: caesarean section; mode of delivery; pregnancy; pregnancy-associated disorders; pregnancy-induced disorders