title: Baeyer-Villiger oxidations: biotechnological approach.
abstract: Baeyer-Villiger monooxygenases (BVMOs) are a very well-known and intensively studied class of flavin-dependent enzymes. Their substrate promiscuity, high chemo-, regio-, and enantioselectivity are prerequisites for the use in synthetic chemistry and should pave the way for successful industrial processes. Nonetheless, only a very limited number of industrial relevant transformations are known, mainly due to the lack of BVMOs stability and cofactor dependency. In this review, we focus on novel BVMO-mediated transformations, BVMOs in cascade type reactions, potential industrial applications, and how limitations have been tackled by the community. Special attention will be put on whole-cell immobilization strategies. We emphasize to bridge recent developments in fundamental research to industrial applications.
authors.affiliation: Department of Glycobiotechnology, Institute of Chemistry - Center for Glycomics, Slovak Academy of Sciences, Dúbravská cesta 9, SK-845 38, Bratislava, Slovakia.
authors.forename: Marek
authors.initials: M
authors.lastname: Bučko
authors.affiliation: Department of Glycobiotechnology, Institute of Chemistry - Center for Glycomics, Slovak Academy of Sciences, Dúbravská cesta 9, SK-845 38, Bratislava, Slovakia. Peter.Gemeiner@savba.sk.
authors.forename: Peter
authors.initials: P
authors.lastname: Gemeiner
authors.affiliation: Department of Glycobiotechnology, Institute of Chemistry - Center for Glycomics, Slovak Academy of Sciences, Dúbravská cesta 9, SK-845 38, Bratislava, Slovakia.
authors.forename: Andrea
authors.initials: A
authors.lastname: Schenkmayerová
authors.affiliation: Department of Glycobiotechnology, Institute of Chemistry - Center for Glycomics, Slovak Academy of Sciences, Dúbravská cesta 9, SK-845 38, Bratislava, Slovakia.
authors.forename: Tomáš
authors.initials: T
authors.lastname: Krajčovič
authors.affiliation: Institute of Applied Synthetic Chemistry, TU Wien, Getreidemarkt 9/163, A-1060, Vienna, Austria. florian.rudroff@tuwien.ac.at.
authors.forename: Florian
authors.initials: F
authors.lastname: Rudroff
authors.affiliation: Institute of Applied Synthetic Chemistry, TU Wien, Getreidemarkt 9/163, A-1060, Vienna, Austria.
authors.forename: Marko D
authors.initials: MD
authors.lastname: Mihovilovič
mesh_terms: D055162:Biocatalysis; D019149:Bioreactors; D001709:Biotechnology; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D006899:Mixed Function Oxygenases
keywords: Asymmetric synthesis; Baeyer-Villiger monooxygenases; Biocatalysis; Cascade reactions; Polyelectrolyte complex capsules; Whole-cell immobilization