title: Hypophosphatemic Rickets in Siblings: A Rare Case Report.
abstract: Hypophosphatemic rickets (HR) is a type of hereditary rickets characterized by persistent hypophosphatemia and hyperphosphaturia. The most predominant type is inherited in an X-linked fashion and caused by mutation in the gene encoding the phosphate-regulating endopeptidase homolog, X-linked (PHEX), identified in 1995. The X-linked hypophosphatemic (XLH) rickets is a rare hereditary metabolic disorder with a prevalence of 1 in 20,000 and causes deficient calcification of mineralized structures such as bones and teeth resulting in dental problems in terms of delayed eruption, spontaneous periapical infections, and exfoliation. We report one such unique case of hypophosphatemic vitamin D-resistant rickets in siblings exhibiting classical features of rickets with emphasis on its treatment and dental considerations.
authors.affiliation: Department of Oral Medicine & Radiology, Drs. Sudha and Nageswara Siddhartha Institute of Dental Sciences, Chinoutpalli, Gannavaram Mandal, Andhra Pradesh 521286, India.
authors.forename: Gummadapu
authors.initials: G
authors.lastname: Sarat
authors.affiliation: Department of Oral Medicine & Radiology, Drs. Sudha and Nageswara Siddhartha Institute of Dental Sciences, Chinoutpalli, Gannavaram Mandal, Andhra Pradesh 521286, India.
authors.forename: Nuthalapati
authors.initials: N
authors.lastname: Priyanka
authors.affiliation: Department of Oral Medicine & Radiology, Drs. Sudha and Nageswara Siddhartha Institute of Dental Sciences, Chinoutpalli, Gannavaram Mandal, Andhra Pradesh 521286, India.
authors.forename: Meka Purna Venkata
authors.initials: MP
authors.lastname: Prabhat
authors.affiliation: Department of Oral Medicine & Radiology, Drs. Sudha and Nageswara Siddhartha Institute of Dental Sciences, Chinoutpalli, Gannavaram Mandal, Andhra Pradesh 521286, India.
authors.forename: Chintamaneni
authors.initials: C
authors.lastname: Raja Lakshmi
authors.affiliation: Department of Oral Medicine & Radiology, Drs. Sudha and Nageswara Siddhartha Institute of Dental Sciences, Chinoutpalli, Gannavaram Mandal, Andhra Pradesh 521286, India.
authors.forename: Sujana Mulk
authors.identifier: 0000-0002-3322-9392
authors.initials: SM
authors.lastname: Bhavana
authors.affiliation: Department of Oral Medicine & Radiology, Drs. Sudha and Nageswara Siddhartha Institute of Dental Sciences, Chinoutpalli, Gannavaram Mandal, Andhra Pradesh 521286, India.
authors.forename: Dharmavaram
authors.initials: D
authors.lastname: Ayesha Thabusum