title: Immunotherapy of Cancer Visualized by Live Microscopy: Seeing Is Believing.
abstract: The success of immunotherapy of cancer depends on several cellular events in the tumors that can be visualized by live microscopy strategies in experimental models. Taking advantage of advanced microscopy techniques, Lehmann and colleagues explore in this issue of CCR the mechanism of action of a novel bispecific mAb (TCB-CEA) that targets membrane-bound CEA and CD3ε. Clin Cancer Res; 22(17); 4277-9. ©2016 AACRSee related article by Lehmann et al., p. 4417.
authors.affiliation: Immunology and Immunotherapy Department, CIMA, Pamplona, Spain.
authors.forename: Alvaro
authors.initials: A
authors.lastname: Teijeira
authors.affiliation: Immunology and Immunotherapy Department, CIMA, Pamplona, Spain.
authors.forename: Iñaki
authors.initials: I
authors.lastname: Etxeberria
authors.affiliation: Oncology Department, University Clinic, University of Navarra and Instituto de Investigacion Sanitaria de Navarra (IdISNA), Pamplona, Spain.
authors.forename: Mariano
authors.initials: M
authors.lastname: Ponz-Sarvise
authors.affiliation: Immunology and Immunotherapy Department, CIMA, Pamplona, Spain. Immunology Department, University Clinic, University of Navarra and Instituto de Investigacion Sanitaria de Navarra (IdISNA), Pamplona, Spain. imelero@unav.es.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Melero
mesh_terms: D000818:Animals; D018033:Antibodies, Bispecific / Q000494:pharmacology; D000951:Antigens, Neoplasm / Q000276:immunology; D000074322:Antineoplastic Agents, Immunological / Q000494:pharmacology; D014408:Biomarkers, Tumor / Q000037:antagonists & inhibitors; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D008853:Microscopy; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy*
chemical_list: D018033:Antibodies, Bispecific; D000951:Antigens, Neoplasm; D000074322:Antineoplastic Agents, Immunological; D014408:Biomarkers, Tumor