title: Joint effects of objectively-measured sedentary time and physical activity on all-cause mortality.
abstract: Examine the joint effects of objectively-measured sedentary time and moderate-to-vigorous physical activity (MVPA) on all-cause mortality.
  
  
  
  The present study included data from the 2003-2006 National Health & Nutrition Examination Survey, with mortality follow-up data (via National Death Index) through 2011 (N=5575U.S. adults). Sedentary time (activity counts/min between 0 and 99) and MVPA (activity counts/min ≥2020) were objectively measured using the ActiGraph 7164 accelerometer.
  
  
  
  The median age of the participants was 50yrs; proportion of men was 50.2%; proportion of whites was 53.8%, 18.7% for blacks; median follow-up was 81months; and 511 deaths occurred over the follow-up period. After adjusting for age, gender, race-ethnicity, cotinine, weight status, poverty level, C-reactive protein and comorbid illness (summed score of 0-8 chronic diseases), and for a 1min increase in MVPA and sedentary time, both MVPA (HRadjusted=0.98; 95% CI: 0.96-0.99; P=0.04) and sedentary time (HRadjusted=1.001; 95% CI: 1.0003-1.002; P=0.008) were independently associated with all-cause mortality. Further, MVPA was associated with all-cause mortality among those with greater (above median) sedentary time (HRadjusted=0.95; 95% CI: 0.93-0.97; P<.001). Sedentary time was not associated with all-cause mortality among those engaging in above median levels of MVPA (HRadjusted=0.998; 95% CI: 0.996-1.001; P=.32), but sedentary time was associated with increased mortality risk among those below median levels of MVPA (HR=1.002; 95% CI: 1.001-1.003; P<0.001).
  
  
  
  Sedentary time and MVPA are independently associated with all-cause mortality. Above median sedentary time levels did not negate the beneficial effects of MVPA on all-cause mortality risk.
authors.affiliation: Physical Activity Epidemiology Laboratory, Jackson Heart Study Vanguard Center of Oxford, Department of Health, Exercise Science, and Recreation Management, The University of Mississippi, University, MS, United States. Electronic address: pdloprin@olemiss.edu.
authors.forename: Paul D
authors.initials: PD
authors.lastname: Loprinzi
authors.affiliation: Kevser Ermin Applied Physiology Laboratory, Department of Health, Exercise Science, and Recreation Management, The University of Mississippi, University, MS, United States.
authors.forename: Jeremy P
authors.initials: JP
authors.lastname: Loenneke
authors.affiliation: Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins Hospital, Baltimore, MD, United States.
authors.forename: Haitham M
authors.initials: HM
authors.lastname: Ahmed
authors.affiliation: Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins Hospital, Baltimore, MD, United States.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Blaha
mesh_terms: D015444:Exercise; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009026:Mortality; D009749:Nutrition Surveys; D012307:Risk Factors; D057185:Sedentary Behavior
keywords: Epidemiology; NHANES; Survival