title: Biotransformation and bioactivation reactions - 2015 literature highlights.
abstract: Since 1972, Drug Metabolism Reviews has been recognized as one of the principal resources for researchers in pharmacological, pharmaceutical and toxicological fields to keep abreast of advances in drug metabolism science in academia and the pharmaceutical industry. With a distinguished list of authors and editors, the journal covers topics ranging from relatively mature fields, such as cytochrome P450 enzymes, to a variety of emerging fields. We hope to continue this tradition with the current compendium of mini-reviews that highlight novel biotransformation processes that were published during the past year. Each review begins with a summary of the article followed by our comments on novel aspects of the research and their biological implications. This collection of highlights is not intended to be exhaustive, but rather to be illustrative of recent research that provides new insights or approaches that advance the field of drug metabolism. Abbreviations NAPQI N-acetyl-p-benzoquinoneimine ALDH aldehyde dehydrogenase AO aldehyde oxidase AKR aldo-keto reductase CES carboxylesterase CSB cystathionine β-synthase CSE cystathionine γ-lyase P450 cytochrome P450 DHPO 2,3-dihydropyridin-4-one ESI electrospray FMO flavin monooxygenase GSH glutathione GSSG glutathione disulfide ICPMS inductively coupled plasma mass spectrometry i.p. intraperitoneal MDR multidrug-resistant NNAL 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol NNK 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone oaTOF orthogonal acceleration time-of-flight PBK physiologically based kinetic PCP pentachlorophenol SDR short-chain dehydrogenase/reductase SULT sulfotransferase TB tuberculosis.
authors.affiliation: a School of Pharmacy, University of Washington , Seattle , WA , USA ;
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Baillie
authors.affiliation: b Department of Drug Metabolism and Pharmacokinetics, Genentech , 1 DNA Way , South San Francisco , CA , USA ;
authors.forename: Deepak
authors.initials: D
authors.lastname: Dalvie
authors.affiliation: c Division of Toxicology , Wageningen University , Wageningen , The Netherlands ;
authors.forename: Ivonne M C M
authors.initials: IM
authors.lastname: Rietjens
authors.affiliation: d Pfizer Global Research and Development, La Jolla Laboratories , San Diego , CA , USA.
authors.forename: S
authors.initials: S
authors.lastname: Cyrus Khojasteh
mesh_terms: D000082:Acetaminophen / Q000493:pharmacokinetics; D000081248:Allylbenzene Derivatives; D000814:Aniline Compounds / Q000493:pharmacokinetics; D000818:Animals; D000840:Anisoles / Q000493:pharmacokinetics; D001553:Benzbromarone / Q000493:pharmacokinetics; D001711:Biotransformation; D006801:Humans; D007093:Imidazoles / Q000493:pharmacokinetics; D009536:Niacinamide / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D009593:Nitroimidazoles / Q000493:pharmacokinetics; D009602:Nitrosamines / Q000493:pharmacokinetics; D010080:Oxazoles / Q000493:pharmacokinetics; D023303:Oxazolidinones / Q000493:pharmacokinetics; D010545:Peroxides / Q000493:pharmacokinetics; D011719:Pyrazines / Q000493:pharmacokinetics; D011720:Pyrazoles / Q000493:pharmacokinetics; D011724:Pyridazines / Q000009:adverse effects / Q000493:pharmacokinetics; D011725:Pyridines / Q000493:pharmacokinetics; D011728:Pyridones / Q000493:pharmacokinetics; D011744:Pyrimidinones / Q000493:pharmacokinetics; D013876:Thiophenes / Q000493:pharmacokinetics; D014230:Triazoles / Q000009:adverse effects / Q000493:pharmacokinetics
chemical_list: C000622435:AZD9819; D000081248:Allylbenzene Derivatives; D000814:Aniline Compounds; D000840:Anisoles; C000622437:GDC-0623; D007093:Imidazoles; C000599304:JNJ38877605; C560621:N-(3-(6-(4-(1,4-dimethyl-3-oxopiperazin-2-yl)phenylamino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl)-2-methylphenyl)-4,5,6,7-tetrahydrobenzo(b)thiophene-2-carboxamide; D009593:Nitroimidazoles; D009602:Nitrosamines; C516022:OPC-67683; D010080:Oxazoles; D023303:Oxazolidinones; D010545:Peroxides; D011719:Pyrazines; D011720:Pyrazoles; D011724:Pyridazines; D011725:Pyridines; D011728:Pyridones; D011744:Pyrimidinones; D013876:Thiophenes; D014230:Triazoles; C012195:asarone; C023621:4-bromoaniline; D009536:Niacinamide; D000082:Acetaminophen; D001553:Benzbromarone; C000590780:contezolid; C099565:4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol
keywords: 2015 review; Bioactivation; biotransformation; literature highlights; metabolism