title: Involvement of regulatory T cells and selected cytokines in the pathogenesis of bronchial asthma.
abstract: Asthma pathogenesis is complex and involves the interplay of many factors and actions. Airway inflammation in allergic asthma is characterized by an exaggerated activation of T helper type 2 cells, IgE production and infiltration and activation of eosinophils. The results of studies conducted in recent years indicate that the deficit of naturally occurring Foxp3+CD25+CD4+ and Foxp3+CD25+CD8+ regulatory T cells and type 1 regulatory T cells plays a pivotal role in the development of this disease. Moreover, numerous studies have provided convincing evidence that a decrease in IL-10 production and an increase in IL-17 production have an important place in the pathophysiology of asthma. TGF-β is another important cytokine involved in this disease. TGF-β has a paradoxical status in relation to asthma pathogenesis because it seems to play a role in both suppressing and promoting asthma development. This review discusses briefly clinical and experimental data concerning the involvement of T regulatory cells and IL-10, IL-17 and TGF-β in the pathogenesis of asthma.
authors.affiliation: Katedra Farmakologii i Toksykologii, Wydział Medycyny Weterynaryjnej, Uniwersytet Warmińsko-Mazurski w Olsztynie.
authors.forename: Monika
authors.initials: M
authors.lastname: Zuśka-Prot
authors.affiliation: Katedra Farmakologii i Toksykologii, Wydział Medycyny Weterynaryjnej, Uniwersytet Warmińsko-Mazurski w Olsztynie.
authors.forename: Jerzy J
authors.initials: JJ
authors.lastname: Jaroszewski
authors.affiliation: Katedra Farmakologii i Toksykologii, Wydział Medycyny Weterynaryjnej, Uniwersytet Warmińsko-Mazurski w Olsztynie.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Maślanka
mesh_terms: D000818:Animals; D001249:Asthma / Q000503:physiopathology*; D015415:Biomarkers / Q000378:metabolism; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000502:physiology*
chemical_list: D015415:Biomarkers