title: Sarcopenia is Associated with Chemotherapy Toxicity in Patients Undergoing Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis from Colorectal Cancer.
abstract: Despite the positive survival results of cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC), criticisms have been put forward regarding the safety of this treatment as a result of a high morbidity rate. Muscle depletion (sarcopenia) is associated with the occurrence of postoperative complications. The purpose of this study was to determine the association between sarcopenia and postoperative morbidity after CRS-HIPEC for peritoneal carcinomatosis from colorectal cancer by distinguishing the complications linked to CRS itself and those associated with chemotherapy (HIPEC) toxicities.
  
  
  
  Data concerning 97 consecutive patients who had undergone CRS-HIPEC were recorded. We analyzed the events occurring within 30 days after surgery that were prospectively recorded in a database. Sarcopenia was assessed using the L3 muscle index on computed tomography performed during the 2 months preceding surgery.
  
  
  
  The sarcopenic patients experienced significantly more chemotherapy toxicities (57 vs. 26 %; p = 0.004) and especially neutropenia (36 vs. 17 %; p = 0.04) than their nonsarcopenic counterparts. There was no difference in complications linked to the CRS procedure between sarcopenic and nonsarcopenic patients. In the multivariate analysis, sarcopenia was the only parameter independently associated with the risk of chemotherapy toxicity (odds ratio 3.97; 95 % confidence interval 1.52-10.39; p = 0.005).
  
  
  
  Despite the local administration of chemotherapy, systemic toxicity was observed in sarcopenic patients after CRS-HIPEC. This relationship favors new treatment strategies with white blood cell growth factors or chemotherapy dosing based on muscle value.
authors.affiliation: Department of Surgical Oncology, Gustave-Roussy Cancer Campus, University of Paris Sud, Villejuif, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Chemama
authors.affiliation: Biostatistics and Epidemiology Unit, Gustave-Roussy Cancer Campus, University of Paris Sud, Villejuif, France.|INSERM U1018, CESP, University of Paris-Saclay, Villejuif, France.
authors.forename: Mohamed Amine
authors.initials: MA
authors.lastname: Bayar
authors.affiliation: Biostatistics and Epidemiology Unit, Gustave-Roussy Cancer Campus, University of Paris Sud, Villejuif, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Lanoy
authors.affiliation: Department of Radiology, Gustave-Roussy Cancer Campus, University of Paris Sud, Villejuif, France.
authors.forename: Samy
authors.initials: S
authors.lastname: Ammari
authors.affiliation: Intensive Care Unit, Gustave-Roussy Cancer Campus, University of Paris Sud, Villejuif, France.
authors.forename: Annabelle
authors.initials: A
authors.lastname: Stoclin
authors.affiliation: Department of Surgical Oncology, Gustave-Roussy Cancer Campus, University of Paris Sud, Villejuif, France.
authors.forename: Diane
authors.initials: D
authors.lastname: Goéré
authors.affiliation: Department of Surgical Oncology, Gustave-Roussy Cancer Campus, University of Paris Sud, Villejuif, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Elias
authors.affiliation: Department of Supportive Care, Gustave-Roussy Cancer Campus, University of Paris Sud, Villejuif, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Raynard
authors.affiliation: Department of Ambulatory Care, Gustave-Roussy Cancer Campus, University of Paris Sud, Villejuif, France. sami.antoun@gustaveroussy.fr.
authors.forename: Sami
authors.initials: S
authors.lastname: Antoun
mesh_terms: D061605:Administration, Intravenous; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects*; D001823:Body Composition; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D015179:Colorectal Neoplasms / Q000473:pathology*; D065426:Cytoreduction Surgical Procedures / Q000009:adverse effects; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D006979:Hyperthermia, Induced / Q000009:adverse effects; D007263:Infusions, Parenteral; D000077146:Irinotecan; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced; D061646:Operative Time; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D000077150:Oxaliplatin; D010534:Peritoneal Neoplasms / Q000556:secondary / Q000628:therapy*; D011183:Postoperative Complications / Q000209:etiology; D055948:Sarcopenia / Q000150:complications*
chemical_list: D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D000077146:Irinotecan; D002955:Leucovorin; D005472:Fluorouracil; D002166:Camptothecin