title: "Bridge Proteins" Link Inflammation and Metabolic Diseases: Potential Targets for Therapeutics.
abstract: Clinical observations support the postulate that chronic low-grade inflammation underlies metabolic diseases and inflammatory mediators can trigger some metabolic diseases. In disorder condition, what is the first one: metabolic diseases cause inflammation or conversely? This "chicken or egg" type question was hard to answer. However, instead of focusing on this difficult issue, we should ask another challenging question: what are the links between inflammation and metabolic diseases? Seizing the key from this chaos may be the best way to solve the problem and break the cycle. To answer this question, we review the regulators (such as NF-κB, PPARs, mTOR, and STAT3) that have important roles in both metabolism and inflammation. These "bridge proteins" that link metabolic diseases and inflammation not only increase our understanding of these two diseases, but also provide potential targets for therapeutics and practical clinical applications.
authors.affiliation: Department of Animal Science, Jilin Agricultural University, No.2888 Xincheng Street, Changchun 130118. China.
authors.forename: Hailong
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Department of Animal Science, Jilin Agricultural University, No.2888 Xincheng Street, Changchun 130118. China.
authors.forename: Guixin
authors.initials: G
authors.lastname: Qin
authors.affiliation: Department of Animal Science, Jilin Agricultural University, No.2888 Xincheng Street, Changchun 130118. China.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Animal Production, Product Quality and Security, Ministry of Education, Jilin Agricultural University, Changchun 130118. China.
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Che
mesh_terms: D000818:Animals; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000276:immunology* / Q000378:metabolism; D008659:Metabolic Diseases / Q000150:complications / Q000276:immunology* / Q000378:metabolism; D016328:NF-kappa B / Q000276:immunology / Q000378:metabolism; D047492:Peroxisome Proliferator-Activated Receptors / Q000276:immunology / Q000378:metabolism; D050796:STAT3 Transcription Factor / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000276:immunology / Q000378:metabolism
chemical_list: D016328:NF-kappa B; D047492:Peroxisome Proliferator-Activated Receptors; D050796:STAT3 Transcription Factor; D058570:TOR Serine-Threonine Kinases
keywords: Inflammation; NF-κB; PPARs; STAT3; mTOR; metabolic disease