title: Tau PET in Alzheimer disease and mild cognitive impairment.
abstract: To investigate the topographical distribution of tau pathology and its effect on functional and structural changes in patients with Alzheimer disease (AD) and mild cognitive impairment (MCI) by using (18)F-AV-1451 PET.
  
  
  
  We included 20 patients with AD, 15 patients with MCI, and 20 healthy controls, and performed neuropsychological function tests, MRI, as well as (18)F-florbetaben (for amyloid) and (18)F-AV-1451 (for tau) PET scans. By using the regional volume-of-interest masks extracted from MRIs, regional binding values of standardized uptake value ratios and volumes were measured. We compared regional binding values among 3 diagnostic groups and identified correlations among the regional binding values, performance in each cognitive function test, and regional atrophy.
  
  
  
  (18)F-AV-1451 binding was increased only in the entorhinal cortex in patients with MCI, while patients with AD exhibited greater binding in most cortical regions. In the 35 patients with MCI and AD, (18)F-AV-1451 binding in most of the neocortex increased with a worsening of global cognitive function. The visual and verbal memory functions were associated with the extent of (18)F-AV-1451 binding, especially in the medial temporal regions. The (18)F-AV-1451 binding also correlated with the severity of regional atrophy of the cerebral cortex.
  
  
  
  Tau PET imaging with (18)F-AV-1451 could serve as an in vivo biomarker for the evaluation of AD-related tau pathology and monitoring disease progression. The accumulation of pathologic tau is more closely related to functional and structural deterioration in the AD spectrum than β-amyloid.
authors.affiliation: From the Departments of Neurology (H.C., M.S.H., Y.J.K., H.M.L., C.H.L., M.S.L.) and Nuclear Medicine (J.Y.C., J.H.L., Y.H.R.), Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Hanna
authors.initials: H
authors.lastname: Cho
authors.affiliation: From the Departments of Neurology (H.C., M.S.H., Y.J.K., H.M.L., C.H.L., M.S.L.) and Nuclear Medicine (J.Y.C., J.H.L., Y.H.R.), Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Jae Yong
authors.initials: JY
authors.lastname: Choi
authors.affiliation: From the Departments of Neurology (H.C., M.S.H., Y.J.K., H.M.L., C.H.L., M.S.L.) and Nuclear Medicine (J.Y.C., J.H.L., Y.H.R.), Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Mi Song
authors.initials: MS
authors.lastname: Hwang
authors.affiliation: From the Departments of Neurology (H.C., M.S.H., Y.J.K., H.M.L., C.H.L., M.S.L.) and Nuclear Medicine (J.Y.C., J.H.L., Y.H.R.), Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Jae Hoon
authors.initials: JH
authors.lastname: Lee
authors.affiliation: From the Departments of Neurology (H.C., M.S.H., Y.J.K., H.M.L., C.H.L., M.S.L.) and Nuclear Medicine (J.Y.C., J.H.L., Y.H.R.), Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: You Jin
authors.initials: YJ
authors.lastname: Kim
authors.affiliation: From the Departments of Neurology (H.C., M.S.H., Y.J.K., H.M.L., C.H.L., M.S.L.) and Nuclear Medicine (J.Y.C., J.H.L., Y.H.R.), Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Hye Mi
authors.initials: HM
authors.lastname: Lee
authors.affiliation: From the Departments of Neurology (H.C., M.S.H., Y.J.K., H.M.L., C.H.L., M.S.L.) and Nuclear Medicine (J.Y.C., J.H.L., Y.H.R.), Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. lyoochel@yuhs.ac.
authors.forename: Chul Hyoung
authors.initials: CH
authors.lastname: Lyoo
authors.affiliation: From the Departments of Neurology (H.C., M.S.H., Y.J.K., H.M.L., C.H.L., M.S.L.) and Nuclear Medicine (J.Y.C., J.H.L., Y.H.R.), Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Young Hoon
authors.initials: YH
authors.lastname: Ryu
authors.affiliation: From the Departments of Neurology (H.C., M.S.H., Y.J.K., H.M.L., C.H.L., M.S.L.) and Nuclear Medicine (J.Y.C., J.H.L., Y.H.R.), Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Myung Sik
authors.initials: MS
authors.lastname: Lee
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000523:psychology; D016229:Amyloid beta-Peptides / Q000378:metabolism; D000814:Aniline Compounds; D001284:Atrophy; D060825:Cognitive Dysfunction / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000523:psychology; D018450:Disease Progression; D018728:Entorhinal Cortex / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory; D009483:Neuropsychological Tests; D049268:Positron-Emission Tomography; D011446:Prospective Studies; D019275:Radiopharmaceuticals; D013267:Stilbenes; D014785:Vision, Ocular; D016875:tau Proteins / Q000378:metabolism*
chemical_list: D016229:Amyloid beta-Peptides; D000814:Aniline Compounds; D019275:Radiopharmaceuticals; D013267:Stilbenes; D016875:tau Proteins; C527756:4-(N-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbene