title: Permeable Thrombi Are Associated With Higher Intravenous Recombinant Tissue-Type Plasminogen Activator Treatment Success in Patients With Acute Ischemic Stroke.
abstract: Preclinical studies showed that thrombus permeability improves recombinant tissue-type plasminogen activator (r-tPA) efficacy. We hypothesize that thrombus permeability estimated from radiological imaging is associated with improved recanalization after treatment with intravenously administered r-tPA (r-tPA) and with better functional outcome.
  
  
  
  We assessed thrombus attenuation increase (TAI) in patients from the Dutch Acute Stroke Study with an occlusion of an intracranial artery on computed tomographic angiography. Patients were included within 9 hours after the stroke onset. After dichotomization of TAI as pervious or impervious, logistic regressions analyses were performed to estimate associations of intravenous r-tPA therapy with complete recanalization and with favorable functional outcome (modified Rankin Scale score of ≤2).
  
  
  
  Three hundred eight patients matched the inclusion criteria. The median TAI was 20.1 (interquartile range, 8.5-37.8) Hounsfield unit (HU). We found a significant increase in the odds of complete recanalization with increasing TAI for patients treated with intravenous r-tPA (P=0.030). One hundred thirty-one (42%) thrombi were classified as pervious with TAI of ≥23 HU. In patients with a pervious thrombus, complete recanalization was more frequent after treatment with intravenous r-tPA than after conservative treatment (odds ratio, 6.26; 95% confidence interval, 2.4-16.8; P<0.001). In patients with an impervious thrombus, the effect of intravenous r-tPA was not significant (odds ratio, 1.4; 95% confidence interval, 0.5-4.1; P=0.47). Favorable outcome was more common in patients with a pervious thrombi than without (odds ratio, 2.1; 95% confidence interval, 1.3-3.4; P=0.001).
  
  
  
  Thrombus perviousness, as measured on computed tomography in the acute stage of ischemic stroke, is strongly associated with recanalization after intravenous r-tPA treatment and with favorable functional outcome.
authors.affiliation: From the Departments of Radiology (E.M.M.S., K.M.T., C.B.M., H.A.M.), Biomedical Engineering and Physics (E.M.M.S., H.A.M.), and Neurology (Y.B.R.), Academic Medical Center, Amsterdam, The Netherlands; Departments of Radiology (E.M.M.S., W.J.N.) and Medical Informatics (E.M.M.S., W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; Departments of Radiology (J.W.D., A.D.H., B.V.) and Neurology (L.J.K.), University Medical Centrum Utrecht, Utrecht, The Netherlands; and Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands (W.J.N.).Catharina Hospital, Eindhoven, The NetherlandsCatharina Hospital, Eindhoven, The NetherlandsErasmus Medical Center, Rotterdam, The NetherlandsErasmus Medical Center, Rotterdam, The NetherlandsGelre Hospitals, Apeldoorn, The NetherlandsGelre Hospitals, Apeldoorn, The NetherlandsLeiden University Medical Center, Leiden, The NetherlandsLeiden University Medical Center, Leiden, The NetherlandsMedical Center Haaglanden, The Hague, The NetherlandsMedical Center Haaglanden, The Hague, The NetherlandsOnze Lieve Vrouwe Gasthuis, Amsterdam, The NetherlandsOnze Lieve Vrouwe Gasthuis, Amsterdam, The NetherlandsRadboud University Nijmegen Medical Centre, Nijmegen, The NetherlandsRadboud University Nijmegen Medical Centre, Nijmegen, The NetherlandsRijnstate Hospital, Arnhem, The NetherlandsRijnstate Hospital, Arnhem, The NetherlandsSt. Antonius Hospital, Nieuwegein, The NetherlandsSt. Antonius Hospital, Nieuwegein, The NetherlandsSt. Elisabeth Hospital, Tilburg, The NetherlandsSt. Elisabeth Hospital, Tilburg, The NetherlandsSt. Franciscus Hospital, Rotterdam, The NetherlandsSt. Franciscus Hospital, Rotterdam, The NetherlandsVU Medical Center, Amsterdam, The NetherlandsVU Medical Center, Amsterdam, The NetherlandsUniversity Medical Center Utrecht, Utrecht, The NetherlandsUniversity Medical Center Utrecht, Utrecht, The NetherlandsUniversity Medical Center Utrecht, Utrecht, The NetherlandsUniversity Medical Center Utrech
authors.forename: Emilie M M
authors.initials: EM
authors.lastname: Santos
authors.affiliation: From the Departments of Radiology (E.M.M.S., K.M.T., C.B.M., H.A.M.), Biomedical Engineering and Physics (E.M.M.S., H.A.M.), and Neurology (Y.B.R.), Academic Medical Center, Amsterdam, The Netherlands; Departments of Radiology (E.M.M.S., W.J.N.) and Medical Informatics (E.M.M.S., W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; Departments of Radiology (J.W.D., A.D.H., B.V.) and Neurology (L.J.K.), University Medical Centrum Utrecht, Utrecht, The Netherlands; and Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands (W.J.N.).Catharina Hospital, Eindhoven, The NetherlandsCatharina Hospital, Eindhoven, The NetherlandsErasmus Medical Center, Rotterdam, The NetherlandsErasmus Medical Center, Rotterdam, The NetherlandsGelre Hospitals, Apeldoorn, The NetherlandsGelre Hospitals, Apeldoorn, The NetherlandsLeiden University Medical Center, Leiden, The NetherlandsLeiden University Medical Center, Leiden, The NetherlandsMedical Center Haaglanden, The Hague, The NetherlandsMedical Center Haaglanden, The Hague, The NetherlandsOnze Lieve Vrouwe Gasthuis, Amsterdam, The NetherlandsOnze Lieve Vrouwe Gasthuis, Amsterdam, The NetherlandsRadboud University Nijmegen Medical Centre, Nijmegen, The NetherlandsRadboud University Nijmegen Medical Centre, Nijmegen, The NetherlandsRijnstate Hospital, Arnhem, The NetherlandsRijnstate Hospital, Arnhem, The NetherlandsSt. Antonius Hospital, Nieuwegein, The NetherlandsSt. Antonius Hospital, Nieuwegein, The NetherlandsSt. Elisabeth Hospital, Tilburg, The NetherlandsSt. Elisabeth Hospital, Tilburg, The NetherlandsSt. Franciscus Hospital, Rotterdam, The NetherlandsSt. Franciscus Hospital, Rotterdam, The NetherlandsVU Medical Center, Amsterdam, The NetherlandsVU Medical Center, Amsterdam, The NetherlandsUniversity Medical Center Utrecht, Utrecht, The NetherlandsUniversity Medical Center Utrecht, Utrecht, The NetherlandsUniversity Medical Center Utrecht, Utrecht, The NetherlandsUniversity Medical Center Utrech
authors.forename: Jan Willem
authors.initials: JW
authors.lastname: Dankbaar
authors.affiliation: From the Departments of Radiology (E.M.M.S., K.M.T., C.B.M., H.A.M.), Biomedical Engineering and Physics (E.M.M.S., H.A.M.), and Neurology (Y.B.R.), Academic Medical Center, Amsterdam, The Netherlands; Departments of Radiology (E.M.M.S., W.J.N.) and Medical Informatics (E.M.M.S., W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; Departments of Radiology (J.W.D., A.D.H., B.V.) and Neurology (L.J.K.), University Medical Centrum Utrecht, Utrecht, The Netherlands; and Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands (W.J.N.).Catharina Hospital, Eindhoven, The NetherlandsCatharina Hospital, Eindhoven, The NetherlandsErasmus Medical Center, Rotterdam, The NetherlandsErasmus Medical Center, Rotterdam, The NetherlandsGelre Hospitals, Apeldoorn, The NetherlandsGelre Hospitals, Apeldoorn, The NetherlandsLeiden University Medical Center, Leiden, The NetherlandsLeiden University Medical Center, Leiden, The NetherlandsMedical Center Haaglanden, The Hague, The NetherlandsMedical Center Haaglanden, The Hague, The NetherlandsOnze Lieve Vrouwe Gasthuis, Amsterdam, The NetherlandsOnze Lieve Vrouwe Gasthuis, Amsterdam, The NetherlandsRadboud University Nijmegen Medical Centre, Nijmegen, The NetherlandsRadboud University Nijmegen Medical Centre, Nijmegen, The NetherlandsRijnstate Hospital, Arnhem, The NetherlandsRijnstate Hospital, Arnhem, The NetherlandsSt. Antonius Hospital, Nieuwegein, The NetherlandsSt. Antonius Hospital, Nieuwegein, The NetherlandsSt. Elisabeth Hospital, Tilburg, The NetherlandsSt. Elisabeth Hospital, Tilburg, The NetherlandsSt. Franciscus Hospital, Rotterdam, The NetherlandsSt. Franciscus Hospital, Rotterdam, The NetherlandsVU Medical Center, Amsterdam, The NetherlandsVU Medical Center, Amsterdam, The NetherlandsUniversity Medical Center Utrecht, Utrecht, The NetherlandsUniversity Medical Center Utrecht, Utrecht, The NetherlandsUniversity Medical Center Utrecht, Utrecht, The NetherlandsUniversity Medical Center Utrech
authors.forename: Kilian M
authors.initials: KM
authors.lastname: Treurniet
authors.affiliation: From the Departments of Radiology (E.M.M.S., K.M.T., C.B.M., H.A.M.), Biomedical Engineering and Physics (E.M.M.S., H.A.M.), and Neurology (Y.B.R.), Academic Medical Center, Amsterdam, The Netherlands; Departments of Radiology (E.M.M.S., W.J.N.) and Medical Informatics (E.M.M.S., W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; Departments of Radiology (J.W.D., A.D.H., B.V.) and Neurology (L.J.K.), University Medical Centrum Utrecht, Utrecht, The Netherlands; and Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands (W.J.N.).Catharina Hospital, Eindhoven, The NetherlandsCatharina Hospital, Eindhoven, The NetherlandsErasmus Medical Center, Rotterdam, The NetherlandsErasmus Medical Center, Rotterdam, The NetherlandsGelre Hospitals, Apeldoorn, The NetherlandsGelre Hospitals, Apeldoorn, The NetherlandsLeiden University Medical Center, Leiden, The NetherlandsLeiden University Medical Center, Leiden, The NetherlandsMedical Center Haaglanden, The Hague, The NetherlandsMedical Center Haaglanden, The Hague, The NetherlandsOnze Lieve Vrouwe Gasthuis, Amsterdam, The NetherlandsOnze Lieve Vrouwe Gasthuis, Amsterdam, The NetherlandsRadboud University Nijmegen Medical Centre, Nijmegen, The NetherlandsRadboud University Nijmegen Medical Centre, Nijmegen, The NetherlandsRijnstate Hospital, Arnhem, The NetherlandsRijnstate Hospital, Arnhem, The NetherlandsSt. Antonius Hospital, Nieuwegein, The NetherlandsSt. Antonius Hospital, Nieuwegein, The NetherlandsSt. Elisabeth Hospital, Tilburg, The NetherlandsSt. Elisabeth Hospital, Tilburg, The NetherlandsSt. Franciscus Hospital, Rotterdam, The NetherlandsSt. Franciscus Hospital, Rotterdam, The NetherlandsVU Medical Center, Amsterdam, The NetherlandsVU Medical Center, Amsterdam, The NetherlandsUniversity Medical Center Utrecht, Utrecht, The NetherlandsUniversity Medical Center Utrecht, Utrecht, The NetherlandsUniversity Medical Center Utrecht, Utrecht, The NetherlandsUniversity Medical Center Utrech
authors.forename: Alexander D
authors.initials: AD
authors.lastname: Horsch
authors.affiliation: From the Departments of Radiology (E.M.M.S., K.M.T., C.B.M., H.A.M.), Biomedical Engineering and Physics (E.M.M.S., H.A.M.), and Neurology (Y.B.R.), Academic Medical Center, Amsterdam, The Netherlands; Departments of Radiology (E.M.M.S., W.J.N.) and Medical Informatics (E.M.M.S., W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; Departments of Radiology (J.W.D., A.D.H., B.V.) and Neurology (L.J.K.), University Medical Centrum Utrecht, Utrecht, The Netherlands; and Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands (W.J.N.).Catharina Hospital, Eindhoven, The NetherlandsCatharina Hospital, Eindhoven, The NetherlandsErasmus Medical Center, Rotterdam, The NetherlandsErasmus Medical Center, Rotterdam, The NetherlandsGelre Hospitals, Apeldoorn, The NetherlandsGelre Hospitals, Apeldoorn, The NetherlandsLeiden University Medical Center, Leiden, The NetherlandsLeiden University Medical Center, Leiden, The NetherlandsMedical Center Haaglanden, The Hague, The NetherlandsMedical Center Haaglanden, The Hague, The NetherlandsOnze Lieve Vrouwe Gasthuis, Amsterdam, The NetherlandsOnze Lieve Vrouwe Gasthuis, Amsterdam, The NetherlandsRadboud University Nijmegen Medical Centre, Nijmegen, The NetherlandsRadboud University Nijmegen Medical Centre, Nijmegen, The NetherlandsRijnstate Hospital, Arnhem, The NetherlandsRijnstate Hospital, Arnhem, The NetherlandsSt. Antonius Hospital, Nieuwegein, The NetherlandsSt. Antonius Hospital, Nieuwegein, The NetherlandsSt. Elisabeth Hospital, Tilburg, The NetherlandsSt. Elisabeth Hospital, Tilburg, The NetherlandsSt. Franciscus Hospital, Rotterdam, The NetherlandsSt. Franciscus Hospital, Rotterdam, The NetherlandsVU Medical Center, Amsterdam, The NetherlandsVU Medical Center, Amsterdam, The NetherlandsUniversity Medical Center Utrecht, Utrecht, The NetherlandsUniversity Medical Center Utrecht, Utrecht, The NetherlandsUniversity Medical Center Utrecht, Utrecht, The NetherlandsUniversity Medical Center Utrech
authors.forename: Yvo B
authors.initials: YB
authors.lastname: Roos
authors.affiliation: From the Departments of Radiology (E.M.M.S., K.M.T., C.B.M., H.A.M.), Biomedical Engineering and Physics (E.M.M.S., H.A.M.), and Neurology (Y.B.R.), Academic Medical Center, Amsterdam, The Netherlands; Departments of Radiology (E.M.M.S., W.J.N.) and Medical Informatics (E.M.M.S., W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; Departments of Radiology (J.W.D., A.D.H., B.V.) and Neurology (L.J.K.), University Medical Centrum Utrecht, Utrecht, The Netherlands; and Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands (W.J.N.).Catharina Hospital, Eindhoven, The NetherlandsCatharina Hospital, Eindhoven, The NetherlandsErasmus Medical Center, Rotterdam, The NetherlandsErasmus Medical Center, Rotterdam, The NetherlandsGelre Hospitals, Apeldoorn, The NetherlandsGelre Hospitals, Apeldoorn, The NetherlandsLeiden University Medical Center, Leiden, The NetherlandsLeiden University Medical Center, Leiden, The NetherlandsMedical Center Haaglanden, The Hague, The NetherlandsMedical Center Haaglanden, The Hague, The NetherlandsOnze Lieve Vrouwe Gasthuis, Amsterdam, The NetherlandsOnze Lieve Vrouwe Gasthuis, Amsterdam, The NetherlandsRadboud University Nijmegen Medical Centre, Nijmegen, The NetherlandsRadboud University Nijmegen Medical Centre, Nijmegen, The NetherlandsRijnstate Hospital, Arnhem, The NetherlandsRijnstate Hospital, Arnhem, The NetherlandsSt. Antonius Hospital, Nieuwegein, The NetherlandsSt. Antonius Hospital, Nieuwegein, The NetherlandsSt. Elisabeth Hospital, Tilburg, The NetherlandsSt. Elisabeth Hospital, Tilburg, The NetherlandsSt. Franciscus Hospital, Rotterdam, The NetherlandsSt. Franciscus Hospital, Rotterdam, The NetherlandsVU Medical Center, Amsterdam, The NetherlandsVU Medical Center, Amsterdam, The NetherlandsUniversity Medical Center Utrecht, Utrecht, The NetherlandsUniversity Medical Center Utrecht, Utrecht, The NetherlandsUniversity Medical Center Utrecht, Utrecht, The NetherlandsUniversity Medical Center Utrech
authors.forename: L Jaap
authors.initials: LJ
authors.lastname: Kappelle
authors.affiliation: From the Departments of Radiology (E.M.M.S., K.M.T., C.B.M., H.A.M.), Biomedical Engineering and Physics (E.M.M.S., H.A.M.), and Neurology (Y.B.R.), Academic Medical Center, Amsterdam, The Netherlands; Departments of Radiology (E.M.M.S., W.J.N.) and Medical Informatics (E.M.M.S., W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; Departments of Radiology (J.W.D., A.D.H., B.V.) and Neurology (L.J.K.), University Medical Centrum Utrecht, Utrecht, The Netherlands; and Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands (W.J.N.).Catharina Hospital, Eindhoven, The NetherlandsCatharina Hospital, Eindhoven, The NetherlandsErasmus Medical Center, Rotterdam, The NetherlandsErasmus Medical Center, Rotterdam, The NetherlandsGelre Hospitals, Apeldoorn, The NetherlandsGelre Hospitals, Apeldoorn, The NetherlandsLeiden University Medical Center, Leiden, The NetherlandsLeiden University Medical Center, Leiden, The NetherlandsMedical Center Haaglanden, The Hague, The NetherlandsMedical Center Haaglanden, The Hague, The NetherlandsOnze Lieve Vrouwe Gasthuis, Amsterdam, The NetherlandsOnze Lieve Vrouwe Gasthuis, Amsterdam, The NetherlandsRadboud University Nijmegen Medical Centre, Nijmegen, The NetherlandsRadboud University Nijmegen Medical Centre, Nijmegen, The NetherlandsRijnstate Hospital, Arnhem, The NetherlandsRijnstate Hospital, Arnhem, The NetherlandsSt. Antonius Hospital, Nieuwegein, The NetherlandsSt. Antonius Hospital, Nieuwegein, The NetherlandsSt. Elisabeth Hospital, Tilburg, The NetherlandsSt. Elisabeth Hospital, Tilburg, The NetherlandsSt. Franciscus Hospital, Rotterdam, The NetherlandsSt. Franciscus Hospital, Rotterdam, The NetherlandsVU Medical Center, Amsterdam, The NetherlandsVU Medical Center, Amsterdam, The NetherlandsUniversity Medical Center Utrecht, Utrecht, The NetherlandsUniversity Medical Center Utrecht, Utrecht, The NetherlandsUniversity Medical Center Utrecht, Utrecht, The NetherlandsUniversity Medical Center Utrech
authors.forename: Wiro J
authors.initials: WJ
authors.lastname: Niessen
authors.affiliation: From the Departments of Radiology (E.M.M.S., K.M.T., C.B.M., H.A.M.), Biomedical Engineering and Physics (E.M.M.S., H.A.M.), and Neurology (Y.B.R.), Academic Medical Center, Amsterdam, The Netherlands; Departments of Radiology (E.M.M.S., W.J.N.) and Medical Informatics (E.M.M.S., W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; Departments of Radiology (J.W.D., A.D.H., B.V.) and Neurology (L.J.K.), University Medical Centrum Utrecht, Utrecht, The Netherlands; and Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands (W.J.N.).Catharina Hospital, Eindhoven, The NetherlandsCatharina Hospital, Eindhoven, The NetherlandsErasmus Medical Center, Rotterdam, The NetherlandsErasmus Medical Center, Rotterdam, The NetherlandsGelre Hospitals, Apeldoorn, The NetherlandsGelre Hospitals, Apeldoorn, The NetherlandsLeiden University Medical Center, Leiden, The NetherlandsLeiden University Medical Center, Leiden, The NetherlandsMedical Center Haaglanden, The Hague, The NetherlandsMedical Center Haaglanden, The Hague, The NetherlandsOnze Lieve Vrouwe Gasthuis, Amsterdam, The NetherlandsOnze Lieve Vrouwe Gasthuis, Amsterdam, The NetherlandsRadboud University Nijmegen Medical Centre, Nijmegen, The NetherlandsRadboud University Nijmegen Medical Centre, Nijmegen, The NetherlandsRijnstate Hospital, Arnhem, The NetherlandsRijnstate Hospital, Arnhem, The NetherlandsSt. Antonius Hospital, Nieuwegein, The NetherlandsSt. Antonius Hospital, Nieuwegein, The NetherlandsSt. Elisabeth Hospital, Tilburg, The NetherlandsSt. Elisabeth Hospital, Tilburg, The NetherlandsSt. Franciscus Hospital, Rotterdam, The NetherlandsSt. Franciscus Hospital, Rotterdam, The NetherlandsVU Medical Center, Amsterdam, The NetherlandsVU Medical Center, Amsterdam, The NetherlandsUniversity Medical Center Utrecht, Utrecht, The NetherlandsUniversity Medical Center Utrecht, Utrecht, The NetherlandsUniversity Medical Center Utrecht, Utrecht, The NetherlandsUniversity Medical Center Utrech
authors.forename: Charles B
authors.initials: CB
authors.lastname: Majoie
authors.affiliation: From the Departments of Radiology (E.M.M.S., K.M.T., C.B.M., H.A.M.), Biomedical Engineering and Physics (E.M.M.S., H.A.M.), and Neurology (Y.B.R.), Academic Medical Center, Amsterdam, The Netherlands; Departments of Radiology (E.M.M.S., W.J.N.) and Medical Informatics (E.M.M.S., W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; Departments of Radiology (J.W.D., A.D.H., B.V.) and Neurology (L.J.K.), University Medical Centrum Utrecht, Utrecht, The Netherlands; and Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands (W.J.N.).Catharina Hospital, Eindhoven, The NetherlandsCatharina Hospital, Eindhoven, The NetherlandsErasmus Medical Center, Rotterdam, The NetherlandsErasmus Medical Center, Rotterdam, The NetherlandsGelre Hospitals, Apeldoorn, The NetherlandsGelre Hospitals, Apeldoorn, The NetherlandsLeiden University Medical Center, Leiden, The NetherlandsLeiden University Medical Center, Leiden, The NetherlandsMedical Center Haaglanden, The Hague, The NetherlandsMedical Center Haaglanden, The Hague, The NetherlandsOnze Lieve Vrouwe Gasthuis, Amsterdam, The NetherlandsOnze Lieve Vrouwe Gasthuis, Amsterdam, The NetherlandsRadboud University Nijmegen Medical Centre, Nijmegen, The NetherlandsRadboud University Nijmegen Medical Centre, Nijmegen, The NetherlandsRijnstate Hospital, Arnhem, The NetherlandsRijnstate Hospital, Arnhem, The NetherlandsSt. Antonius Hospital, Nieuwegein, The NetherlandsSt. Antonius Hospital, Nieuwegein, The NetherlandsSt. Elisabeth Hospital, Tilburg, The NetherlandsSt. Elisabeth Hospital, Tilburg, The NetherlandsSt. Franciscus Hospital, Rotterdam, The NetherlandsSt. Franciscus Hospital, Rotterdam, The NetherlandsVU Medical Center, Amsterdam, The NetherlandsVU Medical Center, Amsterdam, The NetherlandsUniversity Medical Center Utrecht, Utrecht, The NetherlandsUniversity Medical Center Utrecht, Utrecht, The NetherlandsUniversity Medical Center Utrecht, Utrecht, The NetherlandsUniversity Medical Center Utrech
authors.forename: Birgitta
authors.initials: B
authors.lastname: Velthuis
authors.affiliation: From the Departments of Radiology (E.M.M.S., K.M.T., C.B.M., H.A.M.), Biomedical Engineering and Physics (E.M.M.S., H.A.M.), and Neurology (Y.B.R.), Academic Medical Center, Amsterdam, The Netherlands; Departments of Radiology (E.M.M.S., W.J.N.) and Medical Informatics (E.M.M.S., W.J.N.), Erasmus Medical Center, Rotterdam, The Netherlands; Departments of Radiology (J.W.D., A.D.H., B.V.) and Neurology (L.J.K.), University Medical Centrum Utrecht, Utrecht, The Netherlands; and Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands (W.J.N.).Catharina Hospital, Eindhoven, The NetherlandsCatharina Hospital, Eindhoven, The NetherlandsErasmus Medical Center, Rotterdam, The NetherlandsErasmus Medical Center, Rotterdam, The NetherlandsGelre Hospitals, Apeldoorn, The NetherlandsGelre Hospitals, Apeldoorn, The NetherlandsLeiden University Medical Center, Leiden, The NetherlandsLeiden University Medical Center, Leiden, The NetherlandsMedical Center Haaglanden, The Hague, The NetherlandsMedical Center Haaglanden, The Hague, The NetherlandsOnze Lieve Vrouwe Gasthuis, Amsterdam, The NetherlandsOnze Lieve Vrouwe Gasthuis, Amsterdam, The NetherlandsRadboud University Nijmegen Medical Centre, Nijmegen, The NetherlandsRadboud University Nijmegen Medical Centre, Nijmegen, The NetherlandsRijnstate Hospital, Arnhem, The NetherlandsRijnstate Hospital, Arnhem, The NetherlandsSt. Antonius Hospital, Nieuwegein, The NetherlandsSt. Antonius Hospital, Nieuwegein, The NetherlandsSt. Elisabeth Hospital, Tilburg, The NetherlandsSt. Elisabeth Hospital, Tilburg, The NetherlandsSt. Franciscus Hospital, Rotterdam, The NetherlandsSt. Franciscus Hospital, Rotterdam, The NetherlandsVU Medical Center, Amsterdam, The NetherlandsVU Medical Center, Amsterdam, The NetherlandsUniversity Medical Center Utrecht, Utrecht, The NetherlandsUniversity Medical Center Utrecht, Utrecht, The NetherlandsUniversity Medical Center Utrecht, Utrecht, The NetherlandsUniversity Medical Center Utrech
authors.forename: Henk A
authors.initials: HA
authors.lastname: Marquering
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D002545:Brain Ischemia / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D000072226:Computed Tomography Angiography; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D010539:Permeability; D020521:Stroke / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D013927:Thrombosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator
keywords: angiography; permeability; reperfusion; stroke; thrombosis