title: Progression of Cutaneous Vitiligo in a Patient with Large Posterior Choroidal Melanoma: A Case Report.
abstract: OBJECTIVE
  The aim of our study was to report a case of progression of cutaneous vitiligo after large posterior choroidal melanoma diagnosis.
  
  
  METHODS
  The clinical history, fundus findings and histopathological features suggest the diagnosis of cutaneous vitiligous progression after a diagnosis of large posterior choroidal melanoma.
  
  
  RESULTS
  A 30-year-old female, with a personal history of cutaneous vitiligo for 12 years, was diagnosed with choroidal melanoma 18 months previously. The cutaneous vitiligo had progressed over her back, body and arms during the preceding 3 years. She refused treatment because she was in her 28th week of pregnancy. When she came to our clinic her visual symptoms had worsened, and the fundus examination showed a melanocytic choroidal mass. After confirming that there was no extraocular extension, she was treated with enucleation. A histopathological study confirmed the choroidal melanoma diagnosis.
  
  
  CONCLUSIONS
  The association between the progression of vitiligo and the diagnosis of uveal melanoma could be considered a good prognostic factor, as has been described in cases of cutaneous melanoma. A longer follow-up of these patients will allow us to confirm this association.
authors.affiliation: Centro de Oftalmología Barraquer, Barcelona, Spain.
authors.forename: Angela
authors.initials: A
authors.lastname: Ding
authors.affiliation: Centro de Oftalmología Barraquer, Barcelona, Spain; Ocular Oncology Service, Barcelona, Spain; Universitat Internacional de Catalunya (UIC), Barcelona, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Elizalde
authors.affiliation: Centro de Oftalmología Barraquer, Barcelona, Spain; Ocular Oncology Service, Barcelona, Spain; Universitat Internacional de Catalunya (UIC), Barcelona, Spain.
authors.forename: Rafael Ignacio
authors.initials: RI
authors.lastname: Barraquer
keywords: Choroidal melanoma; Cutaneous vitiligo; Pregnancy; Progression