title: Histamine in diabetes: Is it time to reconsider?
abstract: The first studies of histamine and diabetes date back to the 1950s. Since that time the involvement of histamine in diabetes was related to its well known vasoactive properties and permeability leakage effects. In particular, the first evidence for a correlation between histamine and diabetes arose in 1989 when an increase in plasma and leucocyte histamine content was observed. Limited independent evidence followed in the subsequent two decades, focusing on both histamine glyceamic control and macro- and microvascular complications of diabetes. However, recent observations have sparked the question whether it is time to reconsider the functional contribution of histamine in diabetes. We reveal an interesting upsurge in the field which provides scope for new insights into the role of histamine in diabetes.
authors.affiliation: Department of Clinical and Experimental Medicine, University of Florence, Viale Pieraccini 6, 50139, Florence, Italy. Electronic address: apini@unifi.it.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Pini
authors.affiliation: School of Medicine, Pharmacy and Health, Durham University, Stockton-on-Tees TS17 6BH, United Kingdom. Electronic address: ilona.obara@durham.ac.uk.
authors.forename: Ilona
authors.initials: I
authors.lastname: Obara
authors.affiliation: School of Biological and Biomedical Science, Durham University, Durham DH13LE, United Kingdom. Electronic address: emma.battell@durham.ac.uk.
authors.forename: Emma
authors.initials: E
authors.lastname: Battell
authors.affiliation: School of Biological and Biomedical Science, Durham University, Durham DH13LE, United Kingdom. Electronic address: paul.chazot@durham.ac.uk.
authors.forename: Paul L
authors.initials: PL
authors.lastname: Chazot
authors.affiliation: School of Biological and Biomedical Science, Durham University, Durham DH13LE, United Kingdom; Department of Scienza e Tecnologia del Farmaco, University of Turin, Via P. Giuria 9, 10125, Turin, Italy. Electronic address: acrosa@unito.it.
authors.forename: Arianna Carolina
authors.initials: AC
authors.lastname: Rosa
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D048909:Diabetes Complications / Q000097:blood / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D003920:Diabetes Mellitus / Q000097:blood / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D006632:Histamine / Q000378:metabolism*; D006633:Histamine Antagonists / Q000627:therapeutic use; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D011968:Receptors, Histamine / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D001786:Blood Glucose; D006633:Histamine Antagonists; D007004:Hypoglycemic Agents; D011968:Receptors, Histamine; D006632:Histamine
keywords: Diabetes; Histamine; Histamine receptor; Nephropathy; Neuropathy; Retinopathy