title: Silver-Catalyzed Difluoroamidation of Activated Alkenes for the Construction of Difluorinated 3,3-Disubstituted Oxindoles.
abstract: A AgOAc catalyzed difunctionalization of activated alkenes through a difluoroamidic radical addition to afford difluoroamidated 3,3-disubstituted oxindoles has been developed. Various functional groups were well tolerated. Moreover, the product could be efficiently derived to the corresponding difluorofunctionalized alcohol, ketone, and ester in high yields. The mechanistic studies revealed that a radical pathway was involved in the transformation.
authors.affiliation: Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University , Lanzhou 730000, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.affiliation: Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University , Lanzhou 730000, China.
authors.forename: Qiao
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University , Lanzhou 730000, China.
authors.forename: Quanping
authors.initials: Q
authors.lastname: Guo
authors.affiliation: Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University , Lanzhou 730000, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
authors.affiliation: Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University , Lanzhou 730000, China.
authors.forename: Zhaoqing
authors.initials: Z
authors.lastname: Xu
authors.affiliation: Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University , Lanzhou 730000, China.
authors.forename: Yubing
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University , Lanzhou 730000, China.
authors.forename: Mengran
authors.initials: M
authors.lastname: Wang
authors.affiliation: Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University , Lanzhou 730000, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Wang