title: High near-infrared absorbing Cu5FeS4 nanoparticles for dual-modal imaging and photothermal therapy.
abstract: Multifunctional nanomaterials have shown excellent and promising properties for cancer diagnosis and treatment. Herein, we have developed iron doped copper sulfide (Cu5FeS4) nanoparticles with a non-covalent polyethylene glycol (PEG) coating (Cu5FeS4-PEG) for tumor dual-modal imaging and photothermal therapy (PTT). The obtained Cu5FeS4-PEG nanoparticles with high near-infrared absorbance could be used for phototoacoustic (PA) imaging and PTT, whereas Fe(3+) doping offer the nanoparticles the additional property for magnetic resonance (MR) imaging. As shown by PA imaging, Cu5FeS4-PEG exhibit a high tumor uptake (∼10% ID g(-1)) after intravenous injection. In vitro and in vivo cancer treatment further confirm that Cu5FeS4-PEG could act as a novel therapeutic agent for PTT of cancer cells. Our study further promotes the potential applications of multifunctional nanomaterials in a range of tumor diagnoses and treatments.
authors.affiliation: School of Medicine and Life Sciences, Medical College, Soochow University, Suzhou, Jiangsu 215123, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhao
authors.forename: Xuan
authors.initials: X
authors.lastname: Yi
authors.forename: Meifang
authors.initials: M
authors.lastname: Li
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Zhong
authors.forename: Quanliang
authors.initials: Q
authors.lastname: Shi
authors.forename: Kai
authors.initials: K
authors.lastname: Yang
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D003300:Copper; D005260:Female; D005296:Ferrous Compounds; D053768:Metal Nanoparticles; D008807:Mice, Inbred BALB C; D064847:Multimodal Imaging; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging* / Q000628:therapy*; D010789:Phototherapy; D013440:Sulfides
chemical_list: D005296:Ferrous Compounds; D013440:Sulfides; C550757:bornite; D003300:Copper