title: A Case of Cutaneous B-Cell Lymphoma in Longstanding Systemic Lupus Erythematosus.
abstract: BACKGROUND
  The association between lymphoproliferative malignancies and autoimmune rheumatological diseases, such as systemic lupus erythematosus (SLE), remains of great interest. It is known that individuals with immune dysregulation also have an increased risk of lymphoma.
  
  
  OBJECTIVE
  To report a case of primary cutaneous diffuse large B-cell lymphoma of the leg type associated with longstanding SLE, as well as to review the literature for similar cases.
  
  
  METHODS
  A PubMed search was done using the following search terms: lupus and B-cell lymphoma.
  
  
  RESULTS
  Although several studies show that non-Hodgkin lymphoma is significantly increased in SLE, there is currently no literature reporting specifically on the risk of primary cutaneous lymphomas in patients with SLE.
  
  
  CONCLUSIONS
  Our report highlights the possibility that patients with autoimmune disease are at increased risk of not only the classic forms of non-Hodgkin lymphoma but also primary cutaneous B-cell lymphomas.
authors.affiliation: Dermatology Division, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada ajzarins@me.com.
authors.forename: Andrea
authors.initials: A
authors.lastname: Zarins
authors.affiliation: Rheumatology Division, Department of Medicine, The Ottawa Hospital-Riverside Campus, University of Ottawa, Ottawa, Ontario, Canada.
authors.forename: Douglas
authors.initials: D
authors.lastname: Smith
authors.affiliation: Dermatology Division, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
authors.forename: Simone
authors.initials: S
authors.lastname: Fahim
mesh_terms: D000328:Adult; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology; D012878:Skin Neoplasms / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology
keywords: SLE; autoimmunity; cutaneous B-cell lymphoma; lupus