title: Cancer Research Advance in CKLF-like MARVEL Transmembrane Domain Containing Member Family (Review).
abstract: CKLF-like MARVEL transmembrane domain-containing family (CMTM) is a novel family of genes first reported at international level by Peking University Human Disease Gene Research Center. The gene products are between chemokines and the transmembrane-4 superfamily. Loaceted in several human chromosomes, CMTMs, which are unregulated in kinds of tumors, are potential tumor suppressor genes consisting of CKLF and CMTM1 to CMTM8. CMTMs play important roles in immune, male reproductive and hematopoietic systems. Also, it has been approved that CMTM family has strong connection with diseases of autoimmunity, haematopoietic system and haematopoietic system. The in-depth study in recent years found the close relation between CMTMs and umorigenesis, tumor development and metastasis. CMTM family has a significant clinical value in diagnosis and treatment to the diseases linking to tumor and immune system.
authors.affiliation: School of Basic Medical Hebei Medical University, Beijing, China E-mail : liuweihebmu@hebmu.edu.cn, zhengwei301@sina.cn.
authors.forename: Jia
authors.initials: J
authors.lastname: Lu
authors.forename: Qian-Qian
authors.initials: QQ
authors.lastname: Wu
authors.forename: Ya-Bo
authors.initials: YB
authors.lastname: Zhou
authors.forename: Kai-Hua
authors.initials: KH
authors.lastname: Zhang
authors.forename: Bing-Xin
authors.initials: BX
authors.lastname: Pang
authors.forename: Liang
authors.initials: L
authors.lastname: Li
authors.forename: Nan
authors.initials: N
authors.lastname: Sun
authors.forename: Heng-Shu
authors.initials: HS
authors.lastname: Wang
authors.forename: Song
authors.initials: S
authors.lastname: Zhang
authors.forename: Wen-Jian
authors.initials: WJ
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
mesh_terms: D000818:Animals; D018925:Chemokines / Q000378:metabolism*; D006801:Humans; D062792:MARVEL Domain-Containing Proteins / Q000378:metabolism*; D008297:Male; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*
chemical_list: C432676:CKLF protein, human; D018925:Chemokines; D062792:MARVEL Domain-Containing Proteins