title: Association Between Antioxidant Intake/Status and Obesity: a Systematic Review of Observational Studies.
abstract: The global prevalence of obesity has doubled in recent decades. Compelling evidences indicated that obesity was associated with lower concentrations of specific antioxidants which may play a role in the development of obesity-related diseases such as cardiovascular disease. The present review aimed to synthesize the evidence from studies on the association between obesity and antioxidant micronutrients in a systematic manner. Data bases including MEDLINE, Science Direct, and Cochrane were searched from inception to October 2015. Thirty-one articles were reviewed using the MOOSE checklist. Lower concentrations of antioxidants have been reported in obese individuals among age groups worldwide. Circulatory levels of carotenoids, vitamins E and C, as well as zinc, magnesium, and selenium were inversely correlated with obesity and body fat mass. However, studies demonstrated inconsistencies in findings. Lower status of carotenoids, vitamins E and C, zinc, magnesium, and selenium appears to be associated with adiposity. Intervention studies may be needed to establish the causality of these associations.
authors.affiliation: School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW, Australia.
authors.forename: Banafshe
authors.initials: B
authors.lastname: Hosseini
authors.affiliation: School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW, Australia. A.Saedisomeolia@westernsydney.edu.au.|Department of Pharmacy, School of Medicine, Western Sydney University, Richmond, NSW, Australia. A.Saedisomeolia@westernsydney.edu.au.|School of Molecular Bioscience, University of Sydney, Sydney, NSW, Australia. A.Saedisomeolia@westernsydney.edu.au.|School of Medicine, Campbelltown Campus, Western Sydney University, Richmond, NSW, 2560, Australia. A.Saedisomeolia@westernsydney.edu.au.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Saedisomeolia
authors.affiliation: School of Molecular Bioscience, University of Sydney, Sydney, NSW, Australia.
authors.forename: Margaret
authors.initials: M
authors.lastname: Allman-Farinelli
mesh_terms: D050154:Adiposity; D000975:Antioxidants / Q000008:administration & dosage / Q000493:pharmacokinetics; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D018977:Micronutrients / Q000008:administration & dosage / Q000493:pharmacokinetics; D009765:Obesity / Q000097:blood / Q000453:epidemiology; D064887:Observational Studies as Topic
chemical_list: D000975:Antioxidants; D018977:Micronutrients
keywords: Adiposity; Carotenoids; Obesity; Vitamin C; Vitamin E; Zinc