title: Pathogen perception by NLRs in plants and animals: Parallel worlds.
abstract: Intracellular NLR (Nucleotide-binding domain and Leucine-rich Repeat-containing) receptors are sensitive monitors that detect pathogen invasion of both plant and animal cells. NLRs confer recognition of diverse molecules associated with pathogen invasion. NLRs must exhibit strict intramolecular controls to avoid harmful ectopic activation in the absence of pathogens. Recent discoveries have elucidated the assembly and structure of oligomeric NLR signalling complexes in animals, and provided insights into how these complexes act as scaffolds for signal transduction. In plants, recent advances have provided novel insights into signalling-competent NLRs, and into the myriad strategies that diverse plant NLRs use to recognise pathogens. Here, we review recent insights into the NLR biology of both animals and plants. By assessing commonalities and differences between kingdoms, we are able to develop a more complete understanding of NLR function.
authors.affiliation: The Sainsbury Laboratory, Norwich Research Park, Norwich, UK.
authors.forename: Zane
authors.initials: Z
authors.lastname: Duxbury
authors.affiliation: The Sainsbury Laboratory, Norwich Research Park, Norwich, UK.
authors.forename: Yan
authors.initials: Y
authors.lastname: Ma
authors.affiliation: The Sainsbury Laboratory, Norwich Research Park, Norwich, UK.
authors.forename: Oliver J
authors.initials: OJ
authors.lastname: Furzer
authors.affiliation: The Sainsbury Laboratory, Norwich Research Park, Norwich, UK.
authors.forename: Sung Un
authors.initials: SU
authors.lastname: Huh
authors.affiliation: The Sainsbury Laboratory, Norwich Research Park, Norwich, UK.
authors.forename: Volkan
authors.initials: V
authors.lastname: Cevik
authors.affiliation: The Sainsbury Laboratory, Norwich Research Park, Norwich, UK.
authors.forename: Jonathan D G
authors.initials: JD
authors.lastname: Jones
authors.affiliation: Division of Plant and Microbial Sciences, School of Biosciences, University of Exeter, Exeter, UK.
authors.forename: Panagiotis F
authors.initials: PF
authors.lastname: Sarris
mesh_terms: D000818:Animals; D007113:Immunity, Innate; D007239:Infections / Q000276:immunology / Q000378:metabolism*; D000070576:NLR Proteins / Q000502:physiology*; D010944:Plants / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology; D015398:Signal Transduction
chemical_list: D000070576:NLR Proteins
keywords: NLR; animals; effectors; innate immunity; plants; receptors