title: Healing of a soft tissue wound of the neck and jaw osteoradionecrosis using platelet gel.
abstract: Bone osteoradionecrosis is a serious complication of radiation treatment. Current treatment approaches are not curative and treatment response is often poor leading to high social and healthcare costs.
  
  
  
  We report on the first case of osteoradionecrosis with successful restitutio ab integro by repeated administration of platelet gel (PLT-gel) and surgery in a critically ill patient. The administration of PLT-gel during a severe septic episode helped regeneration of bone and soft tissues, shortening the hospital stay of the patient. It was also noted that following applications of PLT-gel, both the use of morphine and the numbers of infective episodes were reduced.
  
  
  
  Additional studies are needed to confirm the promising effect of PLT-gel for the treatment of osteoradionecrosis.
authors.affiliation: Haematology Dept, San Maurizio Regional Hospital, Bolzano, South Tyrol, Italy.|Interdisciplinary Medical Research Center (IMREST), Bolzano, South Tyrol, Italy.|Department of Internal Medicine V, Innsbruck Medical University, Innsbruck, Austria.
authors.forename: Andrea
authors.initials: A
authors.lastname: Piccin
authors.affiliation: Haematology Dept, San Maurizio Regional Hospital, Bolzano, South Tyrol, Italy.|Interdisciplinary Medical Research Center (IMREST), Bolzano, South Tyrol, Italy.|Department of Internal Medicine V, Innsbruck Medical University, Innsbruck, Austria.|Biochemistry Laboratory, San Maurizio Regional Hospital, Bolzano, Italy.
authors.forename: Angela Maria
authors.initials: AM
authors.lastname: Di Pierro
authors.affiliation: Interdisciplinary Medical Research Center (IMREST), Bolzano, South Tyrol, Italy.|Odontostomatology Dept, San Maurizio Regional Hospital, Bolzano, South Tyrol, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Tagnin
authors.affiliation: Interdisciplinary Medical Research Center (IMREST), Bolzano, South Tyrol, Italy.|ENT Dept, San Maurizio Regional Hospital, Bolzano, South Tyrol, Italy.
authors.forename: Carla
authors.initials: C
authors.lastname: Russo
authors.affiliation: Interdisciplinary Medical Research Center (IMREST), Bolzano, South Tyrol, Italy.|ENT Dept, San Maurizio Regional Hospital, Bolzano, South Tyrol, Italy.
authors.forename: Roland
authors.initials: R
authors.lastname: Fustos
authors.affiliation: Haematology Dept, San Maurizio Regional Hospital, Bolzano, South Tyrol, Italy.|Interdisciplinary Medical Research Center (IMREST), Bolzano, South Tyrol, Italy.|Pathology Dept., San Maurizio Regional Hospital, Bolzano, Italy.
authors.forename: Daisy
authors.initials: D
authors.lastname: Corvetta
authors.affiliation: Interdisciplinary Medical Research Center (IMREST), Bolzano, South Tyrol, Italy.|Hospital Pharmacy, San Maurizio Regional Hospital, Bolzano, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Primerano
authors.affiliation: Radiotherapy Dept, Santa Chiara Hospital, Trento, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Magri
authors.affiliation: Interdisciplinary Medical Research Center (IMREST), Bolzano, South Tyrol, Italy.|Odontostomatology Dept, San Maurizio Regional Hospital, Bolzano, South Tyrol, Italy.
authors.forename: Viviana
authors.initials: V
authors.lastname: Conci
authors.affiliation: Transfusion Service, Bolzano, Italy.
authors.forename: Ivo
authors.initials: I
authors.lastname: Gentilini
authors.affiliation: Haematology Dept, San Maurizio Regional Hospital, Bolzano, South Tyrol, Italy.|Interdisciplinary Medical Research Center (IMREST), Bolzano, South Tyrol, Italy.
authors.forename: Evelyn
authors.initials: E
authors.lastname: Burkia Stocker
authors.affiliation: Interdisciplinary Medical Research Center (IMREST), Bolzano, South Tyrol, Italy.|Pathology Dept., San Maurizio Regional Hospital, Bolzano, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Negri
authors.affiliation: Interdisciplinary Medical Research Center (IMREST), Bolzano, South Tyrol, Italy.|Pathology Dept., San Maurizio Regional Hospital, Bolzano, Italy.
authors.forename: Guido
authors.initials: G
authors.lastname: Mazzoleni
authors.affiliation: Department of Internal Medicine V, Innsbruck Medical University, Innsbruck, Austria.
authors.forename: Günther
authors.initials: G
authors.lastname: Gastl
authors.affiliation: Interdisciplinary Medical Research Center (IMREST), Bolzano, South Tyrol, Italy.|Odontostomatology Dept, San Maurizio Regional Hospital, Bolzano, South Tyrol, Italy.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Fontanella
mesh_terms: D003240:Connective Tissue Diseases / Q000628:therapy; D005402:Fistula / Q000628:therapy; D005782:Gels; D006801:Humans; D008297:Male; D008336:Mandibular Diseases / Q000628:therapy*; D008875:Middle Aged; D009333:Neck; D010025:Osteoradionecrosis / Q000628:therapy*; D017713:Platelet Transfusion; D053657:Platelet-Rich Plasma; D012038:Regeneration; D044968:Regenerative Medicine; D014945:Wound Healing
chemical_list: D005782:Gels
keywords: plastic surgery; platelet gel; platelet-rich plasma; radiodermatitis