title: Myocardial effective transverse relaxation time T2* Correlates with left ventricular wall thickness: A 7.0 T MRI study.
abstract: Myocardial effective relaxation time T2* is commonly regarded as a surrogate for myocardial tissue oxygenation. However, it is legitimate to assume that there are multiple factors that influence T2*. To this end, this study investigates the relationship between T2* and cardiac macromorphology given by left ventricular (LV) wall thickness and left ventricular radius, and provides interpretation of the results in the physiological context.
  
  
  
  High spatio-temporally resolved myocardial CINE T2* mapping was performed in 10 healthy volunteers using a 7.0 Tesla (T) full-body MRI system. Ventricular septal wall thickness, left ventricular inner radius, and T2* were analyzed. Macroscopic magnetic field changes were elucidated using cardiac phase-resolved magnetic field maps.
  
  
  
  Ventricular septal T2* changes periodically over the cardiac cycle, increasing in systole and decreasing in diastole. Ventricular septal wall thickness and T2* showed a significant positive correlation, whereas the inner LV radius and T2* were negatively correlated. The effect of macroscopic magnetic field gradients on T2* can be considered minor in the ventricular septum.
  
  
  
  Our findings suggest that myocardial T2* is related to tissue blood volume fraction. Temporally resolved T2* mapping could be beneficial for myocardial tissue characterization and for understanding cardiac (patho)physiology in vivo. Magn Reson Med 77:2381-2389, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
authors.affiliation: Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
authors.forename: Till
authors.initials: T
authors.lastname: Huelnhagen
authors.affiliation: Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
authors.forename: Fabian
authors.initials: F
authors.lastname: Hezel
authors.affiliation: Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
authors.forename: Teresa
authors.initials: T
authors.lastname: Serradas Duarte
authors.affiliation: Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Pohlmann
authors.affiliation: Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
authors.forename: Celal
authors.initials: C
authors.lastname: Oezerdem
authors.affiliation: Institute of Physiology, Charité University Medicine, Berlin, Germany.
authors.forename: Bert
authors.initials: B
authors.lastname: Flemming
authors.affiliation: Institute of Physiology, Charité University Medicine, Berlin, Germany.
authors.forename: Erdmann
authors.initials: E
authors.lastname: Seeliger
authors.affiliation: Working Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine.|DZHK (German Centre for Cardiovascular Research), partner site Berlin, Germany.
authors.forename: Marcel
authors.initials: M
authors.lastname: Prothmann
authors.affiliation: Working Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine.|DZHK (German Centre for Cardiovascular Research), partner site Berlin, Germany.
authors.forename: Jeanette
authors.initials: J
authors.lastname: Schulz-Menger
authors.affiliation: Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.|Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine, Berlin, Germany.|DZHK (German Centre for Cardiovascular Research), partner site Berlin, Germany.
authors.forename: Thoralf
authors.initials: T
authors.lastname: Niendorf
mesh_terms: D000328:Adult; D005260:Female; D006352:Heart Ventricles / Q000033:anatomy & histology* / Q000000981:diagnostic imaging*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009929:Organ Size / Q000502:physiology; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016277:Ventricular Function, Left / Q000502:physiology*
keywords: T2*; cardiac imaging; magnetic resonance imaging; myocardial tissue characterization; myocardial wall thickness; susceptibility weighted imaging; ultrahigh field MR