title: Impact of chronic kidney disease stages on atherosclerotic plaque components on optical coherence tomography in patients with coronary artery disease.
abstract: The progression of coronary atherosclerosis has been influenced by the presence of chronic kidney disease (CKD). This study investigated the impact of CKD stages on coronary plaque components observed on optical coherence tomography (OCT). We investigated 296 native coronary lesions with stable angina pectoris treated with stent implantation. All lesions were divided into the three groups according to the values of estimated glomerular filtration rate (eGFR, mL min-11.73 m-2): the non-CKD group (eGFR ≥60, n = 142), CKD group (15 ≤ eGFR < 60, n = 126), and end-stage kidney disease (ESKD) group (eGFR <15 and/or hemodialysis, n = 28). Among the groups, plaque morphologies at the narrowest culprit sites on OCT were evaluated. The CKD group had a larger lipid arc [207.5 (88.3-264.5) vs. 159.3 (73.3-227.7) degrees, P = 0.037] and longer lipid length [2.4 (0.0-5.7) vs. 0.0 (0.0-4.7) mm, P = 0.017] than the non-CKD group. The ESKD group had a thinner fibrous cap [120 (70-258) vs. 170 (100-270) μm, P = 0.044], higher prevalence of plaque rupture (28.6 vs. 12.3 %, P = 0.038), and larger calcification arc [124.8 (0.0-194.3) vs. 0.0 (0.0-125.4) degrees, P = 0.025] than the non-ESKD group (CKD + non-CKD groups). The presence of CKD was related to the growth of lipidic plaques. Furthermore, the advancement in the CKD stage to ESKD affected the occurrence of plaque rupture or progression of calcification.
authors.affiliation: Cardiovascular Center, Yokosuka Kyosai Hospital, 1-16, Yonegahama-dori, Yokosuka, Kanagawa, 238-8558, Japan.
authors.forename: Tomoyo
authors.initials: T
authors.lastname: Sugiyama
authors.affiliation: Cardiovascular Center, Yokosuka Kyosai Hospital, 1-16, Yonegahama-dori, Yokosuka, Kanagawa, 238-8558, Japan. shigeki55@nifty.com.
authors.forename: Shigeki
authors.initials: S
authors.lastname: Kimura
authors.affiliation: Cardiovascular Center, Yokosuka Kyosai Hospital, 1-16, Yonegahama-dori, Yokosuka, Kanagawa, 238-8558, Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Ohtani
authors.affiliation: Cardiovascular Center, Yokosuka Kyosai Hospital, 1-16, Yonegahama-dori, Yokosuka, Kanagawa, 238-8558, Japan.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Yamakami
authors.affiliation: Cardiovascular Center, Yokosuka Kyosai Hospital, 1-16, Yonegahama-dori, Yokosuka, Kanagawa, 238-8558, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Kojima
authors.affiliation: Cardiovascular Center, Yokosuka Kyosai Hospital, 1-16, Yonegahama-dori, Yokosuka, Kanagawa, 238-8558, Japan.
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Sagawa
authors.affiliation: Cardiovascular Center, Yokosuka Kyosai Hospital, 1-16, Yonegahama-dori, Yokosuka, Kanagawa, 238-8558, Japan.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Hishikari
authors.affiliation: Cardiovascular Center, Yokosuka Kyosai Hospital, 1-16, Yonegahama-dori, Yokosuka, Kanagawa, 238-8558, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hikita
authors.affiliation: Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Ashikaga
authors.affiliation: Cardiovascular Center, Yokosuka Kyosai Hospital, 1-16, Yonegahama-dori, Yokosuka, Kanagawa, 238-8558, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takahashi
authors.affiliation: Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Isobe
mesh_terms: D000368:Aged; D001807:Blood Vessel Prosthesis; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000209:etiology*; D003331:Coronary Vessels / Q000000981:diagnostic imaging; D018450:Disease Progression; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D058226:Plaque, Atherosclerotic / Q000000981:diagnostic imaging / Q000209:etiology*; D051436:Renal Insufficiency, Chronic / Q000150:complications* / Q000473:pathology; D015607:Stents; D041623:Tomography, Optical Coherence
keywords: Atherosclerosis; Chronic kidney disease; Coronary disease; Optical coherence tomography