title: Neurocognitive and behavioral profiles of children with Landau-Kleffner syndrome.
abstract: This is a retrospective study of 14 cases of children with Landau-Kleffner syndrome (LKS), the most prominent feature of which is acquired aphasia. These children were followed at a tertiary care pediatric epilepsy center. From the research data base, all LKS cases with neuropsychological evaluation were extracted. Children ranged in age from 6 to 13 years (M = 9.12; SD = 2.19) at the time of assessment (1 to 10 years post-onset). The majority of the children were white males, and all but one continued to experience seizure activity. Global intellectual functioning ranged from 59 to 101 (M = 82.07; SD = 12.14). Across the 14 cases reviewed, the neuropsychological profiles are considered in the context of neurological and syndrome-related factors. For these cases, 86% demonstrated continued expressive, and 50% had receptive language problems with 57% exhibiting poor auditory processing. Furthermore, 50 to 57% had deficits in auditory working memory and verbal memory. Academically, the majority had poor reading fluency and comprehension; 50% exhibited difficulty with mathematics. Finally, 57% evidenced attentional or other behavioral problems. Better understanding of LKS can assist in targeted assessment and intervention planning.
authors.affiliation: a Department of Educational Psychology, Texas A&M University , College Station , Texas.
authors.forename: Cynthia A
authors.initials: CA
authors.lastname: Riccio
authors.affiliation: a Department of Educational Psychology, Texas A&M University , College Station , Texas.
authors.forename: Stephanie M
authors.identifier: http://orcid.org/0000-0002-3951-8953
authors.initials: SM
authors.lastname: Vidrine
authors.affiliation: c Department of Neurology, Medical College of Georgia at Augusta University , Augusta , Georgia.
authors.forename: Morris J
authors.initials: MJ
authors.lastname: Cohen
authors.affiliation: b Department of Neurology, Medical College of Georgia at Georgia Regents University , Augusta , Georgia.
authors.forename: Delmaris
authors.initials: D
authors.lastname: Acosta-Cotte
authors.affiliation: b Department of Neurology, Medical College of Georgia at Georgia Regents University , Augusta , Georgia.
authors.forename: Yong
authors.initials: Y
authors.lastname: Park
mesh_terms: D000076363:Academic Success; D000293:Adolescent; D002648:Child; D002652:Child Behavior / Q000523:psychology*; D003071:Cognition / Q000502:physiology*; D032882:Comprehension / Q000502:physiology; D005260:Female; D006801:Humans; D007360:Intelligence / Q000502:physiology*; D018887:Landau-Kleffner Syndrome / Q000150:complications / Q000523:psychology*; D008297:Male; D009483:Neuropsychological Tests; D012189:Retrospective Studies
keywords: Aphasia; Landau-Kleffner syndrome; epilepsy; inattention