title: Composite Follicular Lymphoma and CD5-Positive Nodal Marginal Zone Lymphoma.
abstract: Composite CD10-positive low-grade B-cell and CD5-positive low-grade B-cell lymphoma is extremely rare. We report a case of a composite follicular lymphoma (FL) and CD5-positive nodal marginal zone lymphoma (NMZL) in a resected inguinal lymph node of a 72-year-old Japanese male. Histologically, multiple follicles had reactive-germinal centers with tingible body macrophages, a thin mantle zone and a wide marginal zone. The wide marginal zone consisted of medium-sized cells having slightly indented nuclei and clear cytoplasm, indicating monocytoid cells with CD5-positive B-cells. Several follicles had germinal centers filled with many centrocytes, with CD10-positive B-cells. Polymerase chain reaction/sequence analysis of the immunoglobulin heavy chain gene obtained from microdissected regions of CD5-positive NMZL and FL showed different sequences within the CDR3 region. To our knowledge, this is the first report of FL and CD5-positive NMZL.
authors.affiliation: Department of Pathology, Tokai University School of Medicine.
authors.forename: Masashi
authors.initials: M
authors.lastname: Miyaoka
authors.forename: Tomoki
authors.initials: T
authors.lastname: Kikuchi
authors.forename: Joaquim
authors.initials: J
authors.lastname: Carreras
authors.forename: Yukie
authors.initials: Y
authors.lastname: Yara Kikuti
authors.forename: Ken
authors.initials: K
authors.lastname: Omachi
authors.forename: Minoru
authors.initials: M
authors.lastname: Kojima
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Ando
authors.forename: Naoya
authors.initials: N
authors.lastname: Nakamura
mesh_terms: D000368:Aged; D001402:B-Lymphocytes / Q000473:pathology*; D018956:CD5 Antigens / Q000032:analysis*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D018442:Lymphoma, B-Cell, Marginal Zone / Q000473:pathology*; D008224:Lymphoma, Follicular / Q000473:pathology*; D008297:Male
chemical_list: D018956:CD5 Antigens