title: Interpretation of Biochemical Tests Using the Reference Change Value in Monitoring Adverse Effects of Oral Isotretinoin in 102 Ethnic Turkish Patients.
abstract: OBJECTIVE
  The aim of this study was to model the use of reference change values (RCVs) for the follow-up of 4 parameters of patients using oral isotretinoin which is gaining widespread popularity for monitoring the side effects of the treatment.
  
  
  METHODS
  102 patients received 30 mg/day oral isotretinoin for 24 weeks for the diagnosis of acne vulgaris.
  
  
  RESULTS
  Repetitive measurements of the patients were interpreted with RCVs, after comparing the first and second doses based on RCVs: TC, TG, AST and ALT results increased in 12%, 20%, 14% and 12% of the patients respectively. When the first dose was compared with the last dose, the increases were 20%, 29%, 22% and 18% respectively interpreted as significant changes based on laboratory medicine.
  
  
  CONCLUSIONS
  A more sensitive follow-up is possible in the monitorization of adverse effects by using RCVs method.
authors.affiliation: Department of Biochemistry, and gbugdayci@gmail.com.
authors.forename: Guler
authors.initials: G
authors.lastname: Bugdayci
authors.affiliation: Department of Dermatology, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey.
authors.forename: Mualla
authors.initials: M
authors.lastname: Polat
authors.affiliation: Department of Biochemistry, and.
authors.forename: Hamdi
authors.initials: H
authors.lastname: Oguzman
authors.affiliation: Department of Biochemistry, and.
authors.forename: Havva Yasemin
authors.initials: HY
authors.lastname: Cinpolat
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001774:Blood Chemical Analysis; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis* / Q000473:pathology; D003879:Dermatologic Agents / Q000008:administration & dosage* / Q000009:adverse effects*; D004798:Enzymes / Q000097:blood; D005260:Female; D006801:Humans; D015474:Isotretinoin / Q000008:administration & dosage* / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D003879:Dermatologic Agents; D004798:Enzymes; D015474:Isotretinoin
keywords: acne vulgaris; clinical chemistry test; data interpretation; isotretinoin; references values; side effects