title: Spiroindoles as Potential Pharmacophores.
abstract: The spiroindole heterocyclic scaffold is found in many natural products and has been identified as an important bioactive agent. Over the past few decades, various spiroindole-containing compounds have been reported to possess biological properties and hence found in the structure of many synthetic pharmaceuticals. This mini-review describes the most promising examples of this class of compounds possessing biological activity including anticancer, anti-inflammatory, and antimicrobial activities. To the best of our knowledge, the earlier reviews did not cover the pharmaceutical properties of synthetic and naturally occurring spiroindoles; thus, the current review focuses on the biological activity of compounds containing the spiroindole scaffold.
authors.affiliation: Augusta University - Department of Chemistry & Physics Augusta, Georgia,United States.
authors.forename: Siva S
authors.initials: SS
authors.lastname: Panda
authors.forename: Rachel A
authors.initials: RA
authors.lastname: Jones
authors.forename: Praveen
authors.initials: P
authors.lastname: Bachawala
authors.forename: Prabhu P
authors.initials: PP
authors.lastname: Mohapatra