title: Efficacy of Silodosin in Expulsive Therapy for Distal Ureteral Stones: A Randomized Double-blinded Controlled Trial.
abstract: OBJECTIVE
  To evaluate the efficacy of silodosin in the medical expulsive therapy for symptomatic distal ureteral stones.
  
  
  METHODS
  This prospectively randomized controlled trial was carried out from May 2011 to December 2014. In all, 198 patients with radiopaque distal ureteral stones &lt;10 mm in size were eligible: 61 patients in the control group and 62 patients in the silodosin group. The silodosin group received silodosin 8 mg daily, and the control group received lactose tablets. The primary outcome was the expulsion rate. The secondary outcomes the expulsion time, analgesic consumption, lower urinary tract symptoms, colic episodes, and adverse effects. Statistical analyses were performed using a Mann-Whitney U-test and chi-square test.
  
  
  RESULTS
  The final analysis was conducted with 61 control and 62 silodosin patients as the denominator in each randomization arm. The average expulsion times were 6.31 &plusmn; 2.13 days for the silodosin group and 9.73 &plusmn; 2.76 days for the control group (P &lt; .001).
  
  
  CONCLUSIONS
  Treatment with silodosin proved to be safe and effective, as demonstrated by the increased stone expulsion rate, the reduced expulsion time, and the reduced analgesics consumption.&nbsp.
authors.affiliation: Department of Surgery, Division of Urology, Saint Martin De Porres Hospital, Chiayi, Taiwan, R.O.C.
authors.forename: Chung Jing
authors.initials: CJ
authors.lastname: Wang
authors.affiliation: Department of Surgery, Division of Urology, Saint Martin De Porres Hospital, Chiayi, Taiwan, R.O.C.
authors.forename: Po Chao
authors.initials: PC
authors.lastname: Tsai
authors.affiliation: Department of Surgery, Division of Urology, Saint Martin De Porres Hospital, Chiayi, Taiwan, R.O.C.
authors.forename: Chien Hsing
authors.initials: CH
authors.lastname: Chang
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007211:Indoles / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016896:Treatment Outcome; D014514:Ureteral Calculi / Q000188:drug therapy* / Q000473:pathology
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D007211:Indoles; C095285:silodosin