title: The importance of stem cell engineering in head and neck oncology.
abstract: Head and neck squamous cell carcinoma is the sixth leading cause of cancer worldwide. The most common risk factors are carcinogens (tobacco, alcohol), and infection of the human papilloma virus. Surgery is still considered as the treatment of choice in case of head and neck cancer, followed by a reconstructive surgery to enhance the quality of life in the patients. However, the widespread use of artificial implants does not provide appropriate physiological activities and often cannot act as a long-term solution for the patients. Here we review the applicability of multiple stem cell types for tissue engineering of cartilage, trachea, vocal folds and nerves for head and neck injuries. The ability of the cells to self-renew and maintain their pluripotency state makes them an attractive tool in tissue engineering.
authors.affiliation: Department of Head and Neck Surgery, The Greater Poland Cancer Centre, Poznań University of Medical Sciences, Garbary 15 Str., 61-866, Poznan, Poland.|Radiobiology Lab, Department of Medical Physics, The Greater Poland Cancer Centre, Garbary 15 Str., 61-866, Poznan, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Barczak
authors.affiliation: Department of Head and Neck Surgery, The Greater Poland Cancer Centre, Poznań University of Medical Sciences, Garbary 15 Str., 61-866, Poznan, Poland.
authors.forename: Pawel
authors.initials: P
authors.lastname: Golusiński
authors.affiliation: Department of Head and Neck Surgery, The Greater Poland Cancer Centre, Poznań University of Medical Sciences, Garbary 15 Str., 61-866, Poznan, Poland.
authors.forename: Lukasz
authors.initials: L
authors.lastname: Luczewski
authors.affiliation: Radiobiology Lab, Department of Medical Physics, The Greater Poland Cancer Centre, Garbary 15 Str., 61-866, Poznan, Poland. wiktoria.suchorska@wco.pl.|Department of Electroradiology, Poznan University of Medical Sciences, Garbary 15 Str., 61-866, Poznan, Poland. wiktoria.suchorska@wco.pl.
authors.forename: Wiktoria M
authors.initials: WM
authors.lastname: Suchorska
authors.affiliation: Department of Head and Neck Surgery, The Greater Poland Cancer Centre, Poznań University of Medical Sciences, Garbary 15 Str., 61-866, Poznan, Poland.|Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, 6900 Lake Nona Blvd., Orlando, FL, 32827, USA.
authors.forename: Michal M
authors.initials: MM
authors.lastname: Masternak
authors.affiliation: Department of Head and Neck Surgery, The Greater Poland Cancer Centre, Poznań University of Medical Sciences, Garbary 15 Str., 61-866, Poznan, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Golusiński
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000601:surgery*; D002356:Cartilage / Q000294:innervation / Q000502:physiology / Q000637:transplantation; D002454:Cell Differentiation; D006258:Head and Neck Neoplasms / Q000601:surgery*; D006801:Humans; D011788:Quality of Life; D019651:Plastic Surgery Procedures; D013234:Stem Cells / Q000166:cytology*; D023822:Tissue Engineering / Q000379:methods*; D014132:Trachea / Q000294:innervation / Q000502:physiology / Q000637:transplantation; D014827:Vocal Cords / Q000294:innervation / Q000502:physiology / Q000637:transplantation
keywords: HESC; Head and neck cancer; Induced pluripotent stem cells; Mesenchymal stem cells; Stem cell tissue engineering