title: The benefit of exercise training in pulmonary hypertension: a clinical review.
abstract: Pulmonary hypertension (PH) is a clinical condition characterised by raised pulmonary artery pressure, which results in increased right ventricular afterload and dyspnoea. This is accompanied by reduced exercise capacity, quality of life and, eventually, death. An increasing range of targeted medications has transformed the treatment of pulmonary arterial hypertension, a specific type of PH. Supervised exercise training is recommended as part of a multifaceted management plan for PH. However, many questions remain regarding how exercise training improves exercise capacity and quality of life. The optimal exercise regimen (frequency, timing, duration and intensity) also remains unclear. This review provides an update on the pathophysiology of exercise impairment in PH, suggests mechanisms by which exercise may improve symptoms and function and offers evidence-based recommendations regarding the frequency and intensity of an exercise programme for patients with PH.
authors.affiliation: Department of Medicine, University of New South Wales Rural Clinical School, Coffs Harbour, New South Wales, Australia.|Department of Medicine, Coffs Harbour Health Campus, Coffs Harbour, New South Wales, Australia.
authors.forename: Karen S W
authors.initials: KS
authors.lastname: Chia
authors.affiliation: Department of Medicine, University of New South Wales Rural Clinical School, Coffs Harbour, New South Wales, Australia.|Department of Medicine, Coffs Harbour Health Campus, Coffs Harbour, New South Wales, Australia.|Mid-North Coast Arthritis Clinic, Coffs Harbour, New South Wales, Australia.
authors.forename: Peter K K
authors.initials: PK
authors.lastname: Wong
authors.affiliation: Department of Rehabilitation, Sacred Heart Rehabilitation, St Vincent's Health, Sydney, New South Wales, Australia.|Department of Medicine, University of New South Wales, Sydney, New South Wales, Australia.|Department of Medicine, St Vincent's Hospital, Sydney, New South Wales, Australia.
authors.forename: Steven G
authors.initials: SG
authors.lastname: Faux
authors.affiliation: Department of Medicine, University of New South Wales Rural Clinical School, Coffs Harbour, New South Wales, Australia.
authors.forename: Craig S
authors.initials: CS
authors.lastname: McLachlan
authors.affiliation: Department of Medicine, University of New South Wales, Sydney, New South Wales, Australia.|Department of Medicine, St Vincent's Hospital, Sydney, New South Wales, Australia.
authors.forename: Eugene
authors.initials: E
authors.lastname: Kotlyar
mesh_terms: D055317:Evidence-Based Practice; D005081:Exercise Therapy; D017079:Exercise Tolerance / Q000502:physiology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000503:physiopathology / Q000534:rehabilitation / Q000628:therapy*; D015397:Program Evaluation; D011788:Quality of Life; D016896:Treatment Outcome
keywords: exercise training; pulmonary hypertension; rehabilitation