title: Molecular targeted therapy in gynaecologic malignancies: primer for radiologists.
abstract: The identification of characteristic genetic alteration in gynaecological malignancies has opened the door for molecular targeted therapy. The purpose of this review is to provide a primer for the radiologist on these agents with emphasis on the role of imaging in treatment response assessment and drug toxicities. The use of targeted therapy in gynaecological malignancies will likely increase in the future and make the role of the radiologist critical in response assessment and detection of toxicities.
authors.affiliation: 1 Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.|2 Department of Radiology, Namwon Medical Center, Namwon-Si, Jeollabuk-Do, Republic of Korea.
authors.forename: Chong Hyun
authors.initials: CH
authors.lastname: Suh
authors.affiliation: 3 Department of Imaging, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.|4 Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Sree H
authors.initials: SH
authors.lastname: Tirumani
authors.affiliation: 3 Department of Imaging, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.|4 Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Abhishek
authors.initials: A
authors.lastname: Keraliya
authors.affiliation: 1 Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
authors.forename: Kyung Won
authors.initials: KW
authors.lastname: Kim
authors.affiliation: 3 Department of Imaging, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.|4 Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Nikhil H
authors.initials: NH
authors.lastname: Ramaiya
authors.affiliation: 3 Department of Imaging, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.|4 Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Atul B
authors.initials: AB
authors.lastname: Shinagare
mesh_terms: D005260:Female; D005833:Genital Neoplasms, Female / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*