title: The Multiple Roles of XBP1 in Regulation of Glucose and Lipid Metabolism.
abstract: X-box binding protein1 (XBP1) especially exerts its fundamental effects in the cellular organelle endoplasmic reticulum (ER) via affecting three trans-membrane stress sensor proteins: PKRlike ER kinase (PERK), inositol-requiring enzyme 1(IRE1) and activating transcription factor 6(ATF6). At the center of XBP1's broad effects is its remarkable metabolic housekeeper function. XBP1 decreased glucose dysfunction via funneling its effects on improving insulin sensitivity and stimulating insulin secretion. However, XBP1 also yields its double-edged effects, driving the transformation from excess glucose to lipid, which is a key contribution to obesity and T2DM. In this review, we highlight the vital mechanism of XBP1 in manipulating glucose and lipid metabolism involved by multiple signaling pathways.
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang. China.
authors.forename: Jianjing
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Immunology, Binzhou Medical University, Yantai. China.
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Wu
authors.affiliation: Department of Operating Theatre, Binzhou People`s Hospital, Binzhou. China.
authors.forename: Xiaoting
authors.initials: X
authors.lastname: Wu
authors.affiliation: Department of Immunology, Binzhou Medical University, Yantai. China.
authors.forename: Dijia
authors.initials: D
authors.lastname: Zhou
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang. China.
authors.forename: Tengmei
authors.initials: T
authors.lastname: Lin
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang. China.
authors.forename: Saidan
authors.initials: S
authors.lastname: Ding
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Immunology, Binzhou Medical University, Yantai. China.
authors.forename: Jiangnan
authors.initials: J
authors.lastname: Xue
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000. China.
authors.forename: Qichuan
authors.initials: Q
authors.lastname: Zhuge
mesh_terms: D050156:Adipogenesis; D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism; D059865:Endoplasmic Reticulum Stress; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D050356:Lipid Metabolism; D009765:Obesity / Q000378:metabolism; D015398:Signal Transduction; D000071717:X-Box Binding Protein 1 / Q000378:metabolism*
chemical_list: D007328:Insulin; D000071717:X-Box Binding Protein 1; C000605543:XBP1 protein, human; D005947:Glucose
keywords: ER stress; IRE1α; Metabolic regulator/housekeeper; PI3K; XBP1; insulin