title: (Thio)urea-mediated synthesis of functionalized six-membered rings with multiple chiral centers.
abstract: Organocatalysis, now running its second decade of life, is being considered one of the main tools a synthetic chemist has to perform asymmetric catalysis. In this review the synthesis of six-membered rings, that contain multiple chiral centers, either by a ring closing process or by a functionalization reaction on an already existing six-membered ring, utilizing bifunctional (thio)ureas will be summarized. Initially, the use of primary amine-thioureas as organocatalysts for the above transformation is being discussed, followed by the examples employing secondary amine-thioureas. Finally, the use of tertiary amine-thioureas and miscellaneous examples are presented.
authors.affiliation: Department of Chemistry, National and Kapodestrian University of Athens, Panepistimiopolis 15771, Athens, Greece.
authors.forename: Giorgos
authors.initials: G
authors.lastname: Koutoulogenis
authors.affiliation: Department of Chemistry, National and Kapodestrian University of Athens, Panepistimiopolis 15771, Athens, Greece.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Kaplaneris
authors.affiliation: Department of Chemistry, National and Kapodestrian University of Athens, Panepistimiopolis 15771, Athens, Greece.
authors.forename: Christoforos G
authors.initials: CG
authors.lastname: Kokotos
keywords: multiple chiral centers; organocatalysis; six-membered ring; thiourea; urea