title: Caudwell Xtreme Everest: An Overview.
abstract: The Caudwell Xtreme Everest (CXE) expedition in the spring of 2007 systematically studied 222 healthy volunteers as they ascended from sea level to Everest Base Camp (5300 m). A subgroup of climbing investigators ascended higher on Everest and obtained physiological measurements up to an altitude of 8400 m. The aim of the study was to explore inter-individual variation in response to environmental hypobaric hypoxia in order to understand better the pathophysiology of critically ill patients and other patients in whom hypoxaemia and cellular hypoxia are prevalent. This paper describes the aims, study characteristics, organization and management of the CXE expedition.
authors.affiliation: Caudwell Xtreme Everest Research Group, London, UK. mike.grocott@soton.ac.uk.
authors.forename: Michael P W
authors.initials: MP
authors.lastname: Grocott
authors.affiliation: Caudwell Xtreme Everest Research Group, London, UK.
authors.forename: D Z H
authors.initials: DZ
authors.lastname: Levett
authors.affiliation: Caudwell Xtreme Everest Research Group, London, UK.
authors.forename: D S
authors.initials: DS
authors.lastname: Martin
authors.affiliation: Caudwell Xtreme Everest Research Group, London, UK.
authors.forename: M H
authors.initials: MH
authors.lastname: Wilson
authors.affiliation: Caudwell Xtreme Everest Research Group, London, UK.
authors.forename: A
authors.initials: A
authors.lastname: Mackenney
authors.affiliation: Caudwell Xtreme Everest Research Group, London, UK.
authors.forename: S
authors.initials: S
authors.lastname: Dhillon
authors.affiliation: Caudwell Xtreme Everest Research Group, London, UK.
authors.forename: H E
authors.initials: HE
authors.lastname: Montgomery
authors.affiliation: Caudwell Xtreme Everest Research Group, London, UK.
authors.forename: M G
authors.initials: MG
authors.lastname: Mythen
authors.affiliation: Caudwell Xtreme Everest Research Group, London, UK.
authors.forename: K
authors.initials: K
authors.lastname: Mitchell
mesh_terms: D000531:Altitude; D005101:Expeditions; D006801:Humans; D009934:Organization and Administration; D012107:Research Design; D012308:Risk Management; D013223:Statistics as Topic
keywords: Acclimatization; Arterial blood gases; Climbing; Extreme altitude