title: Toxicity, pharmacokinetics, and in vivo efficacy of biotinylated chitosan surface-modified PLGA nanoparticles for tumor therapy.
abstract: Based on our previous work on the PLGA nanoparticles modified with biotinylated chitosan (Bio-CS-PLGA NPs), we further studied the stability, toxicity, pharmacokinetics, and in vivo efficacy. The safety of NPs was studied through single-dose toxicity test in mice, and the result showed that NPs were well tolerated at the dose of 300 mg/kg. Compared with the free EPB group, the NPs group exhibited higher plasma drug concentration, longer half-life time. EPB-loaded NPs significantly inhibited the tumor growth compared to free EPB. All results suggested that Bio-CS-PLGA NPs were stable, safe, and showed a promising potential on targeted drug delivery.
authors.affiliation: a Research Center of Stem Cell and Biotherapy Technology, School of Life Science and Technology , Xinxiang Medical University , Xinxiang , China.
authors.forename: Hongli
authors.initials: H
authors.lastname: Chen
authors.affiliation: a Research Center of Stem Cell and Biotherapy Technology, School of Life Science and Technology , Xinxiang Medical University , Xinxiang , China.
authors.forename: WenBin
authors.initials: W
authors.lastname: Nan
authors.affiliation: a Research Center of Stem Cell and Biotherapy Technology, School of Life Science and Technology , Xinxiang Medical University , Xinxiang , China.
authors.forename: Xiangjuan
authors.initials: X
authors.lastname: Wei
authors.affiliation: a Research Center of Stem Cell and Biotherapy Technology, School of Life Science and Technology , Xinxiang Medical University , Xinxiang , China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: b Institute of Biomedical Engineering , Chinese Academy of Medical Sciences , Tianjin , China.
authors.forename: Feng
authors.initials: F
authors.lastname: Lv
authors.affiliation: c Department of Pharmacy, Beijing Obstetrics and Gynecology Hospital , Capital Medical University , Beijing , China.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Tang
authors.affiliation: a Research Center of Stem Cell and Biotherapy Technology, School of Life Science and Technology , Xinxiang Medical University , Xinxiang , China.
authors.forename: Yonghai
authors.initials: Y
authors.lastname: Li
authors.affiliation: a Research Center of Stem Cell and Biotherapy Technology, School of Life Science and Technology , Xinxiang Medical University , Xinxiang , China.
authors.forename: Chenyan
authors.initials: C
authors.lastname: Zhou
authors.affiliation: a Research Center of Stem Cell and Biotherapy Technology, School of Life Science and Technology , Xinxiang Medical University , Xinxiang , China.
authors.forename: Juntang
authors.initials: J
authors.lastname: Lin
authors.affiliation: a Research Center of Stem Cell and Biotherapy Technology, School of Life Science and Technology , Xinxiang Medical University , Xinxiang , China.
authors.forename: Wuling
authors.initials: W
authors.lastname: Zhu
authors.affiliation: b Institute of Biomedical Engineering , Chinese Academy of Medical Sciences , Tianjin , China.
authors.forename: Qiqing
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D000818:Animals; D019921:Biotinylation; D048271:Chitosan / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods*; D005260:Female; D019344:Lactic Acid / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D011100:Polyglycolic Acid / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D048271:Chitosan
keywords: Biotin; PLGA nanoparticle; chitosan; pharmacokinetics; toxicity; tumor