title: Synthesis of 2-BMIDA 6,5-bicyclic heterocycles by Cu(i)/Pd(0)/Cu(ii) cascade catalysis of 2-iodoaniline/phenols.
abstract: A one-pot cascade reaction for the synthesis of 2-BMIDA 6,5-bicyclic heterocycles has been developed using Cu(i)/Pd(0)/Cu(ii) catalysis. 2-Iodoanilines and phenols undergo a Cu(i)/Pd(0)-catalyzed Sonogashira reaction with ethynyl BMIDA followed by in situ Cu(ii)-catalyzed 5-endo-dig cyclization to generate heterocyclic scaffolds with a BMIDA functional group in the 2-position. The method provides efficient access to borylated indoles, benzofurans, and aza-derivatives, which can be difficult to access through alternative methods.
authors.affiliation: Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, 295 Cathedral St., Glasgow, G1 1XL, UK. allan.watson.100@strath.ac.uk.
authors.forename: Ciaran P
authors.initials: CP
authors.lastname: Seath
authors.affiliation: Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, 295 Cathedral St., Glasgow, G1 1XL, UK. allan.watson.100@strath.ac.uk.
authors.forename: Kirsty L
authors.initials: KL
authors.lastname: Wilson
authors.affiliation: Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, 295 Cathedral St., Glasgow, G1 1XL, UK. allan.watson.100@strath.ac.uk.
authors.forename: Angus
authors.initials: A
authors.lastname: Campbell
authors.affiliation: Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, 295 Cathedral St., Glasgow, G1 1XL, UK. allan.watson.100@strath.ac.uk.
authors.forename: Jenna M
authors.initials: JM
authors.lastname: Mowat
authors.affiliation: Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, 295 Cathedral St., Glasgow, G1 1XL, UK. allan.watson.100@strath.ac.uk.
authors.forename: Allan J B
authors.initials: AJ
authors.lastname: Watson