title: Synthesis, characterization and evaluation of antibacterial activity of (E)-N'-(substituted benzylidene)-2-(2-fluorobenzyl)-5-ethyl-2H-1,2,3-triazole-4-carbohydrazides.
abstract: Triazoles and their derivatives are important precursors in the pharmacological field due to their broad diversity of medicinal and biological deed. In this article, the exploration is to put an effort to produce some novel biologically active triazole 4-carbohydrazide derivatives. The structures of the newly synthesized compounds were characterized and confirmed by spectral data and were screened for anti-bacterial activity. Compounds 5(d-i), 5l and 5m were observed to possess potent anti-microbial activity.
authors.affiliation: Department of Chemistry, Sri Krishnadevaraya University, 515 003, Ananthapuramu, Andhra Pradesh, India.
authors.forename: P V B
authors.initials: PV
authors.lastname: Reddy
authors.affiliation: Denisco Chemicals Pvt. Ltd., 500 055, Hyderabad, Telangana State, India.
authors.forename: V
authors.initials: V
authors.lastname: Kamala Prasad
authors.affiliation: Department of Chemistry, Sri Krishnadevaraya University, 515 003, Ananthapuramu, Andhra Pradesh, India.
authors.forename: G
authors.initials: G
authors.lastname: Manjunath
authors.affiliation: Department of Chemistry, Sri Krishnadevaraya University, 515 003, Ananthapuramu, Andhra Pradesh, India. Electronic address: ramanapv54@gmail.com.
authors.forename: P
authors.initials: P
authors.lastname: Venkata Ramana
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D006834:Hydrazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D006834:Hydrazines; D014230:Triazoles
keywords: Activité antibactérienne; Antibacterial activity; Synthesis of triazoles; Synthèse de triazoles substitués