title: Total Synthesis of Nosiheptide.
abstract: Total synthesis of the bismacrocyclic thiopeptide antibiotic nosiheptide was achieved through the assembly of a fully functionalized linear precursor followed by consecutive macrocyclizations. Key features are a critical macrothiolactonization and a mild deprotection strategy for the 3-hydroxypyridine core. The natural product was identical to isolated authentic material in terms of spectral data and antibiotic activity.
authors.affiliation: Friedrich-Schiller-Universität, Institut für Organische Chemie und Makromolekulare Chemie, Humboldtstrasse 10, 07743, Jena, Germany.
authors.forename: K Philip
authors.initials: KP
authors.lastname: Wojtas
authors.affiliation: Friedrich-Schiller-Universität, Institut für Organische Chemie und Makromolekulare Chemie, Humboldtstrasse 10, 07743, Jena, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Riedrich
authors.affiliation: Friedrich-Schiller-Universität, Institut für Organische Chemie und Makromolekulare Chemie, Humboldtstrasse 10, 07743, Jena, Germany.
authors.forename: Jin-Yong
authors.initials: JY
authors.lastname: Lu
authors.affiliation: Friedrich-Schiller-Universität, Institut für Organische Chemie und Makromolekulare Chemie, Humboldtstrasse 10, 07743, Jena, Germany.
authors.forename: Philipp
authors.initials: P
authors.lastname: Winter
authors.affiliation: Friedrich-Schiller-Universität, Institut für Organische Chemie und Makromolekulare Chemie, Humboldtstrasse 10, 07743, Jena, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Winkler
authors.affiliation: Friedrich-Schiller-Universität, Institut für Organische Chemie und Makromolekulare Chemie, Humboldtstrasse 10, 07743, Jena, Germany.
authors.forename: Sophia
authors.initials: S
authors.lastname: Walter
authors.affiliation: Friedrich-Schiller-Universität, Institut für Organische Chemie und Makromolekulare Chemie, Humboldtstrasse 10, 07743, Jena, Germany. hd.arndt@uni-jena.de.
authors.forename: Hans-Dieter
authors.initials: HD
authors.lastname: Arndt
keywords: antibiotics; heterocycles; macrocycles; peptides; total synthesis