title: Atopy patch test with house dust mite in Chinese patients with atopic dermatitis.
abstract: BACKGROUND
  The atopy patch test (APT) has been defined as an important tool in the diagnosis of cutaneous hypersensitivity caused by house dust mites in atopic dermatitis (AD).
  
  
  OBJECTIVE
  The aim of this study was to evaluate the diagnostic value of the APT to mite allergens by comparing its positive results with those of the skin prick test (SPT) and serum specific IgE test in Chinese AD patients.
  
  
  METHODS
  The APT, SPT and serum specific IgE test with Dermatophagoiodes pteronyssinus and Dermatophagoides farina were performed on a total of 120 patients with atopic dermatitis.
  
  
  RESULTS
  Overall, 37.5% of the patients showed a positive APT reaction to mite allergens. A statistically significant association was observed between positive APT results and air-exposed eczema pattern. The positive APT results were not significantly associated with SCORAD scores and accompanied atopic respiratory disorders in AD patients. A higher frequency of APT positive reactions to mite allergens was observed in adolescent and adult patients. There was no significant difference in APT positivity between extrinsic patients (40.7%) and intrinsic patients (27.6%).
  
  
  CONCLUSIONS
  This study identified house dust mite induced cutaneous hypersensitivity in Chinese patients with AD by APT, especially in air-exposed distribution patterns or adolescent and adult patients. Both intrinsic and extrinsic AD patients showed positive APT reactions to house dust mite.
authors.affiliation: Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.
authors.forename: X
authors.initials: X
authors.lastname: Dou
authors.affiliation: Department of Dermatology, Huashan Hospital Fudan University, Shanghai, China.
authors.forename: J
authors.initials: J
authors.lastname: Kim
authors.affiliation: Department of Dermatology, Huashan Hospital Fudan University, Shanghai, China.
authors.forename: C Y
authors.initials: CY
authors.lastname: Ni
authors.affiliation: Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Shao
authors.affiliation: Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.
authors.forename: J
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D002648:Child; D002675:Child, Preschool; D002681:China; D003876:Dermatitis, Atopic / Q000276:immunology*; D004391:Dust; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008925:Mites / Q000276:immunology*; D010328:Patch Tests; D055815:Young Adult
chemical_list: D004391:Dust