title: IgG4-related disease: A concise review of the current literature.
abstract: IgG4-related disease is the term used to refer to a condition characterized by a lymphoplasmacytic infiltrate, fibrosis and an increased number of IgG4+ cells present in tissue, in most cases, with an elevated serum IgG4 level. This disease frequently affects the pancreas, salivary glands and lymph nodes, but can involve almost any tissue. Its etiology and the exact role of the different inflammatory cells in the damage to the target organ is still unclear. As yet, there is no international consensus about diagnostic criteria for the disease, but there are important advances in its treatment and in the quest to achieve remission. We include a review of the history, possible pathogenesis, clinical manifestations, diagnostic approach and available therapeutic approaches.
authors.affiliation: Servicio de Medicina Interna, Hospital Manuel Uribe Angel, Envigado, Antioquia, Colombia.
authors.forename: Oscar
authors.initials: O
authors.lastname: Ardila-Suarez
authors.affiliation: Department of Rheumatology, Mayo Clinic, Jacksonville, Florida, Estados Unidos.
authors.forename: Andy
authors.initials: A
authors.lastname: Abril
authors.affiliation: Grupo de Inmunología Celular e Inmunogenética (GICIG), Universidad de Antioquia, Colombia. Electronic address: jgomezpuerta@mail.harvard.edu.
authors.forename: José A
authors.initials: JA
authors.lastname: Gómez-Puerta
mesh_terms: D001327:Autoimmune Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology* / Q000628:therapy; D015415:Biomarkers / Q000378:metabolism; D014943:Global Health; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D015994:Incidence; D015995:Prevalence
chemical_list: D015415:Biomarkers; D007074:Immunoglobulin G
keywords: Autoimmune pancreatitis; Enfermedad de Mikulicz; Enfermedad relacionada con IgG4; IgG4-related disease; Immunoglobulin G4; Inmunoglobulina G4; Mikulicz’ disease; Pancreatitis autoinmune