title: [Percutaneous Phil™-Embolization for Preoperative Therapy of Carotid Body Paragangliomas].
abstract: Introduction:Paragangliomas are rare tumors representing a therapeutic challenge. In particular, the surgical removal may lead to life-threatening bleeding. The preoperative percutaneous embolization is an alternative that allows a high closure rate of tumor-feeding vessels in a short intervention time and thus significantly reduces intraoperative bleeding probability. Complete tumor resection is facilitated thereby. The use of a new non-adhesive liquid embolic agent is presented here.Methods:A 50-year old patient presented with 4 cm large paraganglioma of the carotid body (Shamblin II). A percutaneous embolization with 7 ml PHIL™ (injectable precipitating hydrophobic liquid) was performed preoperatively. 24 h later the complete surgical resection of the tumor was performed.Results:A good distribution of the liquid embolic agent could be achieved over the entire tumor. Intraoperative resection of the tumor was much easier and faster due to low bleeding tendency over the entire surface of the tumor. Total blood loss was less than 50 ml. All adjacent nerve and arterial structures could be spared. Postoperative nerve function was normal and the patient was discharged on the 4thpostoperative day.Conclusion:The combination of percutaneous embolization and surgical resection provides a safe combination in the treatment of advanced carotid body paragangliomas. The use of a novel liquid embolic agent may possibly further optimize the therapy.
authors.affiliation: HNO-Klinik, Klinikum Augsburg, Augsburg.
authors.forename: G
authors.initials: G
authors.lastname: Psychogios
authors.affiliation: Klinik für Diagnostische Radiologie und Neuroradiologie, Klinikum Augsburg, Augsburg.
authors.forename: A
authors.initials: A
authors.lastname: Berlis
authors.affiliation: Institut für Pathologie, Klinikum Augsburg, Augsburg.
authors.forename: B
authors.initials: B
authors.lastname: Märkl
authors.affiliation: Institut für Pathologie, Klinikum Augsburg, Augsburg.
authors.forename: T
authors.initials: T
authors.lastname: Schaller
authors.affiliation: Abteilung für Neuroradiologie, Universitätsmedizin Göttingen, Göttingen.
authors.forename: M N
authors.initials: MN
authors.lastname: Psychogios
authors.affiliation: HNO-Klinik, Klinikum Augsburg, Augsburg.
authors.forename: J
authors.initials: J
authors.lastname: Zenk
mesh_terms: D002345:Carotid Body Tumor / Q000098:blood supply / Q000628:therapy*; D003131:Combined Modality Therapy; D004621:Embolization, Therapeutic / Q000379:methods*; D006470:Hemorrhage / Q000517:prevention & control; D006801:Humans; D007431:Intraoperative Complications / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D011145:Polyvinyls / Q000627:therapeutic use*
chemical_list: D011145:Polyvinyls; C020320:ethylene-vinyl alcohol copolymer