title: Complications of indwelling central venous catheters in pediatric liver transplant recipients.
abstract: In pLT recipients, the advantages of ICVCs need to be weighed against the risk of complications. This single-center retrospective study aimed to review ICVC complications in our cohort of pLT recipients. We performed chart reviews of pLT patients having undergone transplant between 01/2000 and 03/2014 and who underwent ICVC placement either before or after LT. We identified 100 ICVC in 85 patients. Overall observation time was 90 470 catheter-days. There was no difference in catheter lifespan between those inserted pre- or post-transplant; 46% of ICVC presented a complication. Most frequent complications were MD and infection. The infection rate was 0.09 per 1000 catheter-days, and MD rate was 0.36 per 1000 catheter-days. Patients having received technical variant grafts were more at risk of complications. To the best of our knowledge, this is the first study examining ICVC complications in pLT recipients. We conclude that ICVC have a high rate of MD. Children receiving technical variants may be more at risk of complications. By removing ICVC in a select number of patients at six months post-insertion, we might avoid as much as 60% of complications.
authors.affiliation: Pediatric Gastroenterology Unit, University Hospitals Geneva, Geneva, Switzerland.
authors.forename: Vladimir L
authors.initials: VL
authors.lastname: Cousin
authors.affiliation: Division of Pediatric Surgery, University Hospitals Geneva, Geneva, Switzerland.
authors.forename: Barbara E
authors.initials: BE
authors.lastname: Wildhaber
authors.affiliation: Department of Pediatrics, University Hospitals Geneva, Geneva, Switzerland.
authors.forename: Charlotte M
authors.initials: CM
authors.lastname: Verolet
authors.affiliation: Pediatric Gastroenterology Unit, University Hospitals Geneva, Geneva, Switzerland.|Department of Pediatrics, University Hospitals Geneva, Geneva, Switzerland.
authors.forename: Dominique C
authors.initials: DC
authors.lastname: Belli
authors.affiliation: Department of Pediatrics, University Hospitals Geneva, Geneva, Switzerland.
authors.forename: Klara M
authors.identifier: http://orcid.org/0000-0001-9464-5704
authors.initials: KM
authors.lastname: Posfay-Barbe
authors.affiliation: Pediatric Gastroenterology Unit, University Hospitals Geneva, Geneva, Switzerland.
authors.forename: Valérie A
authors.initials: VA
authors.lastname: McLin
mesh_terms: D055499:Catheter-Related Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D002405:Catheterization, Central Venous / Q000009:adverse effects* / Q000295:instrumentation; D002408:Catheters, Indwelling / Q000009:adverse effects*; D062905:Central Venous Catheters / Q000009:adverse effects*; D002675:Child, Preschool; D004868:Equipment Failure / Q000706:statistics & numerical data*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D053208:Kaplan-Meier Estimate; D016031:Liver Transplantation; D016015:Logistic Models; D008297:Male; D019990:Perioperative Care / Q000009:adverse effects* / Q000295:instrumentation; D012189:Retrospective Studies; D012307:Risk Factors
keywords: catheter; children; devices; dysfunction; infection; liver; mechanical; pediatric; transplantation