title: Synthesis of 1,2,4-Triazolo[4,3-a]pyridines and Related Heterocycles by Sequential Condensation and Iodine-Mediated Oxidative Cyclization.
abstract: A facile and efficient approach to access 1,2,4-triazolo[4,3-a]pyridines and related heterocycles has been accomplished through condensation of readily available aryl hydrazines with corresponding aldehydes followed by iodine-mediated oxidative cyclization. This transition-metal-free synthetic process is broadly applicable to a variety of aromatic, aliphatic, and α,β-unsaturated aldehydes, and can be conveniently conducted on the gram scale.
authors.affiliation: College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 450001, P.R. China.
authors.forename: Ertong
authors.initials: E
authors.lastname: Li
authors.affiliation: College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 450001, P.R. China.
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Hu
authors.affiliation: College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 450001, P.R. China.
authors.forename: Lina
authors.initials: L
authors.lastname: Song
authors.affiliation: College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 450001, P.R. China. wenquan_yu@zzu.edu.cn.
authors.forename: Wenquan
authors.initials: W
authors.lastname: Yu
authors.affiliation: College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 450001, P.R. China. changjunbiao@zzu.edu.cn.
authors.forename: Junbiao
authors.initials: J
authors.lastname: Chang
keywords: C−N bond formation; heterocycles; iodine; oxidative cyclization; synthesis design