title: EETs and HO-1 cross-talk.
abstract: Epoxygenase-dependent metabolites of arachidonc acid, EETs and the heme-oxygenase (HO)-1/carbon monoxide/bilverdin system share similarities in their activity and mediators. They control endothelial function, dilating small arterial vessels, decrease blood pressure, protect the heart from ischemic and hypertensive cardiopathy, control renal circulation and function, promote angiogenesis and organ regeneration, oppose oxidative stress and inflammation, improve diabetes and obesity, have protective effects on the liver, and participate in portal hypertension. Furthermore, EETs induce HO-1, and inhibition of HO-1 abolishes most of the effects of EETs. Thus, a close interaction between the two systems exists, and is relevant in view of their therapeutic potential.
authors.affiliation: Department of Medicine, University of Padova, Padova, Italy.
authors.forename: David
authors.initials: D
authors.lastname: Sacerdoti
authors.affiliation: Department of Medicine, University of Padova, Padova, Italy. Electronic address: paola.pesce82@libero.it.
authors.forename: Paola
authors.initials: P
authors.lastname: Pesce
authors.affiliation: Department of Medicine, University of Padova, Padova, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Di Pascoli
authors.affiliation: Department of Medicine, University of Padova, Padova, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Bolognesi
mesh_terms: D015126:8,11,14-Eicosatrienoic Acid / Q000378:metabolism*; D000818:Animals; D051547:Heme Oxygenase-1 / Q000378:metabolism*; D006801:Humans; D058990:Molecular Targeted Therapy
chemical_list: D051547:Heme Oxygenase-1; D015126:8,11,14-Eicosatrienoic Acid
keywords: AA; Arachidonic acid; CO; Carbon monoxide; Diabetes; EET; Epoxyeicosatrienoic acid; HO-1; Heme oxygenase; Hypertension; Myocardial infarction; NAFLD