title: Silver acetate exposure: Effects on reproduction and post natal development.
abstract: Effects of oral silver acetate exposure were assessed in P generation and F generation post-natal day 26 rats. Male and female Sprague Dawley rats (n = 20 each) were exposed to silver acetate at 0.4, 4.0 or 40.0 mg/kg bw in their drinking water for 10 weeks prior to and during mating. Females were exposed to silver acetate throughout gestation and lactation. Clinical signs, body weight, feed and fluid consumption were recorded regularly. Decreased mean daily fluid consumption was observed in male and female animals during the 10 week pre mating period and during gestation in the 40 mg/kg bw dose group. Decreased fertility was observed in the 40 mg/kg bw dose group. Decreased feed consumption was observed across all dose groups and decreased mean daily fluid consumption was observed in the 4.0 mg/kg dose group during lactation. Decreased implant numbers, mean numbers of pups born/litter and numbers of live pups born/litter was observed in the 40 mg/kg bw dose group. Pup weight was reduced on lactation days 0, 4 and 7 (males) and 4, 7 and 21 (females) in the 4.0 mg/kg bw dose group and in males at lactation day 21 (40 mg/kg bw dose group). Runting was observed in males (Lactation Day; LD 4) and female (LD 4 and 7) animals in the 4.0 mg/kg bw dose group. Reduced postnatal-day 26 pup weight was observed in male pups in the 40 mg/kg bw dose group and female pups in the 4.0 mg/kg bw dose group.
authors.affiliation: Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, United States Food and Drug Administration, Laurel, MD, United States. Electronic address: Robert.sprando@fda.hhs.gov.
authors.forename: Robert L
authors.initials: RL
authors.lastname: Sprando
authors.affiliation: Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, United States Food and Drug Administration, Laurel, MD, United States.
authors.forename: Thomas
authors.initials: T
authors.lastname: Black
authors.affiliation: Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, United States Food and Drug Administration, Laurel, MD, United States.
authors.forename: Zachary
authors.initials: Z
authors.lastname: Keltner
authors.affiliation: Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, United States Food and Drug Administration, Laurel, MD, United States.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Olejnik
authors.affiliation: Division of Public Health Informatics, Office of Analytics and Outreach, Center for Food Safety and Applied Nutrition, United States Food and Drug Administration, Laurel, MD, United States.
authors.forename: Martine
authors.initials: M
authors.lastname: Ferguson
mesh_terms: D000085:Acetates / Q000633:toxicity*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005260:Female; D007774:Lactation / Q000187:drug effects; D008297:Male; D036801:Parturition / Q000187:drug effects; D011247:Pregnancy; D051381:Rats / Q000254:growth & development*; D017207:Rats, Sprague-Dawley; D012098:Reproduction / Q000187:drug effects*; D018030:Silver Compounds / Q000633:toxicity*; D013270:Stomach / Q000187:drug effects / Q000254:growth & development; D018675:Toxicity Tests
chemical_list: D000085:Acetates; D018030:Silver Compounds; C103100:silver acetate
keywords: Growth suppression; Maternal exposure; Rodent model; Silver acetate