title: Clinical characterization of influenza A and human respiratory syncytial virus among patients with influenza like illness.
abstract: Influenza A and Respiratory Syncytial Virus (RSV) has been recognized as a major cause of acute respiratory tract infection. H1N1 is one of the subtypes of influenza A, pandemic worldwide in July 2009, causing 18,449 deaths globally. To investigate the prevalence and clinical manifestation of the influenza A, H1N1pdm09, and RSV. Throat/nasal swab collected from the patients of all age group either outpatients/inpatients having respiratory illness from 2 to 5 days. The clinical data were recorded in a predesigned questionnaire. RNA was extracted and analyzed by real time PCR at a tertiary care center, 2009-2014. Total 4,352 samples tested for influenza A and H1N1. Out of 4,352, 32.2% (median positivity 21%; range 16-41% during 6 years) were positive for influenza A and 19% were H1N1 (median positivity 16.7%; range 8.7-23% during 6 years). Total 1653 samples were analyzed for RSV from 2011 to 2014, 12% were RSV positive (median positivity 11.35%; range 10-16.3% during 4 years). Pharyngitis, dyspnea were frequent symptoms in influenza A and H1N1 (P < 0.005) whereas bronchiolitis and pneumonia were commonly present in RSV (P < 0.005). The positivity of influenza A and H1N1 was higher in age-group 21-30, whereas RSV in infant and children. H1N1 and RSV were co-circulated and have common clinical symptoms particularly in lower age group. Therefore, laboratory confirmation is necessary for further disease prognosis. Age was an important risk factor that affects the positivity of influenza A, H1N1, and RSV. Different clinical manifestation of H1N1 and RSV will be helpful for early and accurate diagnosis. J. Med. Virol. 89:49-54, 2017. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, U.P., India.|Chhatrapati Shahuji Maharaj Medical University, Lucknow, U.P., India.
authors.forename: Swati
authors.initials: S
authors.lastname: Saxena
authors.affiliation: Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, U.P., India.
authors.forename: Dharamveer
authors.initials: D
authors.lastname: Singh
authors.affiliation: Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, U.P., India.
authors.forename: Amreen
authors.initials: A
authors.lastname: Zia
authors.affiliation: Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, U.P., India.
authors.forename: Jyoti
authors.initials: J
authors.lastname: Umrao
authors.affiliation: Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, U.P., India.
authors.forename: Naveen
authors.initials: N
authors.lastname: Srivastava
authors.affiliation: Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, U.P., India.
authors.forename: Ankita
authors.initials: A
authors.lastname: Pandey
authors.affiliation: Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, U.P., India.
authors.forename: Sushma
authors.initials: S
authors.lastname: Singh
authors.affiliation: Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, U.P., India.
authors.forename: Piyali
authors.initials: P
authors.lastname: Bhattacharya
authors.affiliation: Chhatrapati Shahuji Maharaj Medical University, Lucknow, U.P., India.
authors.forename: Reema
authors.initials: R
authors.lastname: Kumari
authors.affiliation: Chhatrapati Shahuji Maharaj Medical University, Lucknow, U.P., India.
authors.forename: Ramawadh
authors.initials: R
authors.lastname: Kushwaha
authors.affiliation: Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, U.P., India. tndhole@gmail.com.
authors.forename: T N
authors.initials: TN
authors.lastname: Dhole
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D016021:Epidemiologic Studies; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D007223:Infant; D007231:Infant, Newborn; D053118:Influenza A Virus, H1N1 Subtype / Q000302:isolation & purification*; D007251:Influenza, Human / Q000453:epidemiology* / Q000473:pathology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000032:analysis / Q000235:genetics / Q000302:isolation & purification; D060888:Real-Time Polymerase Chain Reaction; D018357:Respiratory Syncytial Virus Infections / Q000453:epidemiology* / Q000473:pathology*; D018113:Respiratory Syncytial Virus, Human / Q000302:isolation & purification*; D011795:Surveys and Questionnaires; D062606:Tertiary Care Centers; D055815:Young Adult
chemical_list: D012367:RNA, Viral
keywords: epidemiology; influenza virus; respiratory tract infection