title: Optical Coherence Tomography of De Novo Lesions and In-Stent Restenosis in Coronary Saphenous Vein Grafts (OCTOPUS Study).
abstract: BACKGROUND
  The OCTOPUS registry prospectively evaluates the procedural and long-term outcomes of saphenous vein graft (SVG) PCI. The current study assessed the morphology of de novo lesions and in-stent restenosis (ISR) in patients undergoing PCI of SVG.
  
  
  RESULTS
  Optical coherence tomography (OCT) of SVG lesions in consecutive patients presenting with stable CAD and ACS was carried out. Thirty-nine patients (32 de novo and 10 ISR lesions) were included in the registry. ISR occurred in 5 BMS and 5 DES. There were no differences in the presence of plaque rupture and thrombus between de novo lesions and ISR. Lipid-rich tissue was identified in both de novo lesions and in ISR (75% vs. 50%, P=0.071) with a higher prevalence in BMS than in DES (23% vs. 7.5%; P=0.048). Calcific de novo lesions were detected in older grafts as compared with non-calcific atheromas (159±57 vs. 90±62 months after CABG, P=0.001). Heterogeneous neointima was found only in ISR (70% vs. 0, P<0.001) and was observed with similar frequency in both BMS and DES (24% vs. 30%, P=0.657). ISR was detected earlier in DES than BMS (median, 50 months; IQR, 18-96 months vs. 27 months; IQR, 13-29 months, P<0.001).
  
  
  CONCLUSIONS
  OCT-based characteristics of de novo and ISR lesions in SVG were similar except for heterogeneous tissue, which was observed only in ISR. (Circ J 2016; 80: 1804-1811).
authors.affiliation: Third Department of Cardiology, Medical University of Silesia.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Roleder
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Pociask
authors.forename: Wojciech
authors.initials: W
authors.lastname: Wańha
authors.forename: Magdalena
authors.initials: M
authors.lastname: Dobrolińska
authors.forename: Paweł
authors.initials: P
authors.lastname: Gąsior
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Smolka
authors.forename: Wojciech
authors.initials: W
authors.lastname: Walkowicz
authors.forename: Tomasz
authors.initials: T
authors.lastname: Jadczyk
authors.forename: Tomasz
authors.initials: T
authors.lastname: Bochenek
authors.forename: Dariusz
authors.initials: D
authors.lastname: Dudek
authors.forename: Andrzej
authors.initials: A
authors.lastname: Ochała
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Mizia-Stec
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Gąsior
authors.forename: Michał
authors.initials: M
authors.lastname: Tendera
authors.forename: Ziad A
authors.initials: ZA
authors.lastname: Ali
authors.forename: Wojciech
authors.initials: W
authors.lastname: Wojakowski
mesh_terms: D000368:Aged; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000601:surgery; D005260:Female; D006083:Graft Occlusion, Vascular / Q000000981:diagnostic imaging / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention; D058226:Plaque, Atherosclerotic / Q000000981:diagnostic imaging / Q000601:surgery; D011446:Prospective Studies; D012501:Saphenous Vein / Q000000981:diagnostic imaging*; D015607:Stents; D041623:Tomography, Optical Coherence; D019737:Transplants