title: Genetic polymorphisms of T-1131C APOA5 and ALOX5AP SG13S114 with the susceptibility of ischaemic stroke in Morocco.
abstract: Ischaemic stroke is a multifactorial disease. Genetic polymorphisms involved in lipid, inflammatory and thrombotic metabolisms play an important role in the development of ischaemic stroke. The present study aimed to assess the relationship between T1131C APOA5 and SG13S114 ALOX5AP polymorphisms and the risk of ischemic stroke in 175 cases and 201 controls. Genotyping was performed by high resolution melting and polymerase chain reaction restriction fragment length polymorphism methods. In the case of T-1131C APOA5, a modest risk of ischaemic stroke was noticed with CC (OR: 2.86; 95% CI = 1.24-6.58; Pc = 0.039) and C allele (OR: 1.54; 95% CI = 1.01-2.33; Pc = 0.014). For SG13S114 ALOX5AP, a significant association was observed among subjects with TT (OR: 2.57; 95% CI =1.49-4.83; Pc = 0.009) and T allele (OR: 1.59; 95% CI = 1.16-2.19; Pc = 0.008). According to the risk factors of ischaemic stroke, a positive correlation was observed only between SG13S114 variant of ALOX5AP gene and hypertension (Pc = 0.026). Despite lower sample size, T-1131C APOA5 and SG13S114 variants could be considered an independent genetic risk factor of ischaemic stroke in Moroccan population.
authors.affiliation: Faculty of Medicine and Pharmacy 14, Department of Genetics and Molecular Pathology Laboratory (LGPM), Hassan II University, 9154 Casablanca, Morocco.br.diakite@yahoo.fr.
authors.forename: Brehima
authors.initials: B
authors.lastname: Diakite
authors.forename: Khalil
authors.initials: K
authors.lastname: Hamzi
authors.forename: Wiam
authors.initials: W
authors.lastname: Hmimech
authors.forename: Sellama
authors.initials: S
authors.lastname: Nadifi
mesh_terms: D058927:5-Lipoxygenase-Activating Proteins / Q000235:genetics*; D000483:Alleles; D000072040:Apolipoprotein A-V / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D015870:Gene Expression; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009018:Morocco; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012307:Risk Factors; D020521:Stroke / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology
chemical_list: D058927:5-Lipoxygenase-Activating Proteins; C548592:ALOX5AP protein, human; C437704:APOA5 protein, human; D000072040:Apolipoprotein A-V