title: Serum levels of Mac-2 binding protein increase with cardiovascular risk and reflect silent atherosclerosis.
abstract: Mac-2 binding protein (M2BP) was reported to be a useful biomarker for liver fibrosis and malignant tumors. We hypothesized that expression of M2BP might also change in the process of atherosclerosis.
  
  
  
  This study included subjects who visited our hospital for a physical checkup.
  
  
  
  The M2BP levels in subjects with hypertension, dyslipidemia, or abnormal glucose metabolism were higher than those in subjects without such risk factors. Moreover, the M2BP levels were associated with severity of cardiovascular risk. Subdivision of M2BP levels into quartiles revealed that M2BP was significantly associated with reactive oxygen metabolites, central systolic blood pressure, and radial augmentation index (AI). Logistic regression analysis with the endpoint of high radial AI (above mean value) showed that high radial AI was independently associated with high M2BP.
  
  
  
  Although the spectrum was narrow as compared to that in cases of hepatic fibrosis, serum M2BP may reflect silent atherosclerosis in apparently healthy subjects.
authors.affiliation: Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan. Electronic address: tomosugi@med.nagoya-cu.ac.jp.
authors.forename: Tomonori
authors.initials: T
authors.lastname: Sugiura
authors.affiliation: Department of Internal Medicine, Faculty of Rehabilitation Science, Nagoya Gakuin University, Seto, Japan.
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Dohi
authors.affiliation: Department of Internal Medicine, Enshu Hospital, Hamamatsu, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takase
authors.affiliation: Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors.forename: Sumiyo
authors.initials: S
authors.lastname: Yamashita
authors.affiliation: Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Murai
authors.affiliation: Department of Virology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Tsuzuki
authors.affiliation: Department of Virology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors.forename: Shintaro
authors.initials: S
authors.lastname: Ogawa
authors.affiliation: Department of Virology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Tanaka
authors.affiliation: Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Ohte
mesh_terms: D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000097:blood*; D050197:Atherosclerosis / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000097:blood*; D003920:Diabetes Mellitus / Q000097:blood; D050171:Dyslipidemias / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000097:blood; D007249:Inflammation; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000097:blood*; D008113:Liver Neoplasms / Q000097:blood*; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood*; D008875:Middle Aged; D015999:Multivariate Analysis; D018384:Oxidative Stress; D017534:Radial Artery / Q000473:pathology; D017382:Reactive Oxygen Species / Q000378:metabolism; D012044:Regression Analysis; D012307:Risk Factors; D012680:Sensitivity and Specificity; D013599:Systole
chemical_list: D000951:Antigens, Neoplasm; D001786:Blood Glucose; D008562:Membrane Glycoproteins; D017382:Reactive Oxygen Species; C114782:TAA90K protein, human
keywords: Atherosclerosis; Augmentation index; Cardiovascular risk factor; Mac-2 binding protein; Oxidative stress