title: Synthesis and cytotoxic evaluation of novel indenoisoquinoline-substituted triazole hybrids.
abstract: The synthesis of various substituted triazole-indenoisoquinoline hybrids was performed based on a CuI-catalyzed 1,3-cycloaddition between propargyl-substituted derivatives and the azide-containing indenoisoquinoline. Besides, a variety of N-(alkyl)propargylindenoisoquinolines was used as substrates for the construction of triazole-indenoisoquinoline-AZT conjugated via a click chemistry-mediated coupling with 3'-azido-3'-deoxythymidine (AZT). Thus, twenty three new indenoisoquinoline-substituted triazole hybrids were successfully prepared and evaluated as cytotoxic agents, revealing an interesting anticancer activity of four triazole linker-indenoisoquinoline-AZT hybrids in KB and HepG2 cancer cell lines.
authors.affiliation: Institute of Chemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam; Thuyloi University, 175, Tay Son, Hanoi, Vietnam.
authors.forename: Tham
authors.initials: T
authors.lastname: Pham Thi
authors.affiliation: Institute of Chemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
authors.forename: Thuy Giang
authors.initials: TG
authors.lastname: Le Nhat
authors.affiliation: Institute of Chemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
authors.forename: Thuong
authors.initials: T
authors.lastname: Ngo Hanh
authors.affiliation: Institute of Chemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam; Hanoi Pedagogical University No. 2, Vietnam.
authors.forename: Tan
authors.initials: T
authors.lastname: Luc Quang
authors.affiliation: Institute of Chemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam; Thainguyen University of Science, Tanthinh, Thainguyen, Vietnam.
authors.forename: Chinh
authors.initials: C
authors.lastname: Pham The
authors.affiliation: Institute of Chemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
authors.forename: Tuyet Anh
authors.initials: TA
authors.lastname: Dang Thi
authors.affiliation: Institute of Chemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
authors.forename: Ha Thanh
authors.initials: HT
authors.lastname: Nguyen
authors.affiliation: Institute of Chemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
authors.forename: Thu Ha
authors.initials: TH
authors.lastname: Nguyen
authors.affiliation: Institute of Chemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
authors.forename: Phuong
authors.initials: P
authors.lastname: Hoang Thi
authors.affiliation: Institute of Chemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam. Electronic address: ngvtuyen@hotmail.com.
authors.forename: Tuyen
authors.initials: T
authors.lastname: Van Nguyen
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D056945:Hep G2 Cells; D006801:Humans; D007546:Isoquinolines / Q000737:chemistry / Q000494:pharmacology*; D007624:KB Cells; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D007546:Isoquinolines; D014230:Triazoles
keywords: AZT; Cytotoxic agents; Hybrids; Indenoisoquinolines; Triazole