title: Minimal-deviation Endometrioid Adenocarcinoma of the Cervix: A Case Report With Ultrastructural Analysis Demonstrating Abnormal Ciliation of the Tumor Cells.
abstract: Minimal-deviation endometrioid adenocarcinoma (MDEA) of the uterine cervix is a rare tumor that may be confused histologically with a number of benign lesions as well as other types of endocervical neoplasia. The histologic and immunohistochemical features of MDEA have been described in case reports and in small series, but correlation of these findings with ultrastructural examination has not been documented. Herein we report a 51-yr-old patient who underwent hysterectomy for menorrhagia and was found to have a clinically unsuspected, stage IB cervical MDEA. The light microscopic, immunohistochemical, and electron microscopic features of the tumor are described, with the most significant ultrastructural abnormality being the presence of abnormal cilia and ciliogenesis.
authors.affiliation: Department of Histopathology, King Edward Memorial Hospital (P.R.G., C.J.R.S.)Schools of Women's and Infants' Health (C.J.R.S.)Pathology and Laboratory Medicine (J.M.P.), University of Western Australia, Perth, Western Australia.
authors.forename: Paul R
authors.initials: PR
authors.lastname: Gould
authors.forename: Colin J R
authors.initials: CJR
authors.lastname: Stewart
authors.forename: John M
authors.initials: JM
authors.lastname: Papadimitriou
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000473:pathology / Q000648:ultrastructure; D018269:Carcinoma, Endometrioid / Q000175:diagnosis* / Q000473:pathology / Q000648:ultrastructure; D002584:Cervix Uteri / Q000473:pathology / Q000648:ultrastructure; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000648:ultrastructure