title: Gene-therapy trials must proceed with caution.
mesh_terms: D000293:Adolescent; D000818:Animals; D064113:CRISPR-Cas Systems / Q000235:genetics; D002986:Clinical Trials as Topic / Q000331:legislation & jurisprudence; D015316:Genetic Therapy / Q000009:adverse effects* / Q000266:history / Q000639:trends*; D005822:Genetic Vectors / Q000009:adverse effects / Q000235:genetics; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008297:Male; D051379:Mice; D020163:Ornithine Carbamoyltransferase Deficiency Disease / Q000235:genetics* / Q000628:therapy*; D014481:United States; D014486:United States Food and Drug Administration / Q000331:legislation & jurisprudence