title: The emergence and outbreak of multidrug-resistant typhoid fever in China.
abstract: Typhoid fever remains a severe public health problem in developing countries. The emergence of resistant typhoid, particularly multidrug-resistant typhoid infections, highlights the necessity of monitoring the resistance characteristics of this invasive pathogen. In this study, we report a typhoid fever outbreak caused by multidrug-resistant Salmonella enterica serovar Typhi strains with an ACSSxtT pattern. Resistance genes conferring these phenotypes were harbored by a large conjugative plasmid, which increases the threat of Salmonella Typhi and thus requires close surveillance for dissemination of strains containing such genes.
authors.affiliation: Department of Diarrheal Disease, State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.|Department of Diarrheal Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, Zhejiang 310000, China.
authors.forename: Meiying
authors.initials: M
authors.lastname: Yan
authors.affiliation: Department of Diarrheal Disease, Xinjiang Center for Disease Control and Prevention, Urumqi, Xinjiang 830000, China.
authors.forename: Xinlan
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Diarrheal Disease, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
authors.forename: Qiaohong
authors.initials: Q
authors.lastname: Liao
authors.affiliation: Department of Diarrheal Disease, Xinjiang Center for Disease Control and Prevention, Urumqi, Xinjiang 830000, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Diarrheal Disease, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Diarrheal Disease, State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.|Department of Diarrheal Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, Zhejiang 310000, China.
authors.forename: Biao
authors.initials: B
authors.lastname: Kan
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002681:China / Q000453:epidemiology; D004269:DNA, Bacterial; D004196:Disease Outbreaks; D024901:Drug Resistance, Multiple, Bacterial; D005838:Genotype; D006801:Humans; D010957:Plasmids; D012485:Salmonella typhi / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D014435:Typhoid Fever / Q000453:epidemiology* / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial