title: Comparisons of the survival time of patients with ovarian cancer adopting post-operative chemotherapy by use of paclitaxel combined with carboplatin or nedaplatin.
abstract: BACKGROUND
  The current study aims to evaluate and compare the efficacy of post-operative chemotherapy using paclitaxel plus carboplatin or nedaplatin in patients with ovarian cancer, as well as the effects of different combinational therapies on the survival times of patients.
  
  
  METHODS
  Ninety-four patients were recruited for the study. These ovarian cancer patients were admitted into the Cancer Hospital Affiliated with Harbin Medical University for surgery from January 2008 to October 2009. They were divided into different groups according to their post-operative chemotherapy schemes: paclitaxel plus carboplatin (CBP group, n = 48) and paclitaxel plus nedaplatin (NDP group, n = 46). Variance analysis was used to compare the effects of different chemotherapy schemes and pathological types of ovarian cancer on the level of CA125 in serum at different treatment time points. Univariate and multivariate analyses were employed to evaluate the survival times of patients in different groups and pathological types and ages.
  
  
  RESULTS
  No significant differences were observed regarding the effects of various chemotherapy schemes (P = 0.561) and pathological types (P = 0.903) on the level of CA125 in serum of patients with ovarian cancer. However, the duration of chemotherapy had a profound impact on the level of CA125 in serum (P < 0.001). The survival times of patients was not affected by age (P = 0.101) and pathological type of ovarian cancer (P = 0.94) significantly. However, it was significantly affected by the chemotherapy scheme.
  
  
  CONCLUSIONS
  Combined chemotherapy using carboplatin plus paclitaxel should be considered as the preferred treatment scheme for the initial treatment of ovarian cancer.
authors.affiliation: Department of Gynaecology, The Third Affiliated Hospital of Harbin Medical University, 150# Hapin Street, Xiangfang District, Harbin, 150040, Heilongjiang, China.
authors.forename: Hongfei
authors.initials: H
authors.lastname: Gao
authors.affiliation: Social Medicine Department of Harbin Medical University, 157# Baojian Road, Nan'gang District, Harbin, 150081, Heilongjiang, China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Yuan
authors.affiliation: Department of Gynaecology, The Third Affiliated Hospital of Harbin Medical University, 150# Hapin Street, Xiangfang District, Harbin, 150040, Heilongjiang, China. wbqwyc@gmail.com.
authors.forename: Yimin
authors.initials: Y
authors.lastname: Han
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D002291:Carcinoma, Papillary / Q000188:drug therapy / Q000401:mortality* / Q000473:pathology; D018284:Cystadenocarcinoma, Serous / Q000188:drug therapy / Q000401:mortality* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000401:mortality* / Q000473:pathology; D017239:Paclitaxel / Q000008:administration & dosage; D011182:Postoperative Care; D011379:Prognosis; D015996:Survival Rate
chemical_list: D009944:Organoplatinum Compounds; C053989:nedaplatin; D016190:Carboplatin; D017239:Paclitaxel
keywords: CA125; Carboplatin; Nedaplatin; Ovarian cancer; Survival time