title: Structural characterization and hypolipidemic effect of Cyclocarya paliurus polysaccharide in rat.
abstract: Polysaccharide is one of the important active ingredients of Cyclocarya paliurus (Batal.) Iljinskaja leaves. The aims of this work were to analyze the structure of the polysaccharide of Cyclocarya paliurus (Batal.) Iljinskaja leaves (CPP), and to investigate the antihyperlipidemic effect of CPP on high-fat emulsion (HFE)-induced hyperlipidaemic rats. CPP, comprised of two polysaccharides with average molecular weight (Mw) of 1.35×10(5)Da and 9.34×10(3)Da, was consisted of rhamnose, arabinose, xylose, mannose, glucose and galactose in the molar ratio of 1.00:2.23:0.64:0.49:0.63:4.16. Oral administration of CPP could significantly decrease levels of serum total cholesterol (TC), triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C), increase high density lipoprotein (HDL-C) in hyperlipidemic rats. CPP exerts therapeutic effects on hyperlipidaemic rats, by up-regulating expressions of adipose triglyceride lipase (ATGL) and peroxisome proliferator-activated receptor alpha (PPARα), via down-regulating fatty acid synthase (FAS) and hydroxy methylglutaryl coenzyme A reductase (HMG-CoA). This study demonstrates that CPP may be beneficial for the treatment of hyperlipidemia.
authors.affiliation: Key Lab for Agro-product Processing and Quality Control of Nanchang City, College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang 330045, China.
authors.forename: Zhan-Wei
authors.initials: ZW
authors.lastname: Yang
authors.affiliation: College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China.
authors.forename: Ke-Hui
authors.initials: KH
authors.lastname: Ouyang
authors.affiliation: Key Lab for Agro-product Processing and Quality Control of Nanchang City, College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang 330045, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Key Lab for Agro-product Processing and Quality Control of Nanchang City, College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang 330045, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.affiliation: Key Lab for Agro-product Processing and Quality Control of Nanchang City, College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang 330045, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Xiong
authors.affiliation: Key Lab for Agro-product Processing and Quality Control of Nanchang City, College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang 330045, China. Electronic address: wwjun9999@sina.com.
authors.forename: Wen-Jun
authors.initials: WJ
authors.lastname: Wang
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D059305:Diet, High-Fat / Q000009:adverse effects; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D000960:Hypolipidemic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D029525:Juglandaceae / Q000737:chemistry*; D050356:Lipid Metabolism / Q000187:drug effects; D008074:Lipoproteins / Q000097:blood; D018515:Plant Leaves / Q000737:chemistry; D011134:Polysaccharides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000960:Hypolipidemic Agents; D008074:Lipoproteins; D011134:Polysaccharides
keywords: Characterization; Cyclocarya paliurus (Batal) Iljinskaja; Hypolipemic mechanism; Polysaccharide