title: Coenzyme Q10 and Utility in Heart Failure: Just Another Supplement?
abstract: Heart failure affects 5.1 million people in the USA annually. It accounts for a frequent cause of hospitalizations and disability. Patients with congestive heart failure have lower plasma levels of CoQ10, which is an independent predictor of mortality in this patient population. It has been hypothesized that a deficiency of CoQ10 can play a role in the development and worsening of heart failure, and that oral supplementation can possibly improve symptoms and survival in these patients. Based on previous small studies and meta-analyses, the use of CoQ10 in heart failure suggested an improvement ejection fraction, stroke volume, cardiac output, and cardiac index with CoQ10 supplementation, however most of these small studies appeared to be underpowered to result in any significant data. The results of the recent Q-SYMBIO trial demonstrated an improvement in heart failure symptoms with a significant reduction in major adverse cardiovascular events and mortality.
authors.affiliation: Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School-University of Queensland School of Medicine, New Orleans, LA, USA. soleck@ochsner.org.|Department of Cardiology, 1514 Jefferson Highway, New Orleans, LA, 70121, USA. soleck@ochsner.org.
authors.forename: Sylvia
authors.initials: S
authors.lastname: Oleck
authors.affiliation: Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School-University of Queensland School of Medicine, New Orleans, LA, USA.
authors.forename: Hector O
authors.initials: HO
authors.lastname: Ventura
mesh_terms: D002302:Cardiac Output; D002986:Clinical Trials as Topic; D019587:Dietary Supplements; D006333:Heart Failure / Q000097:blood* / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D013318:Stroke Volume; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000172:deficiency
chemical_list: D014451:Ubiquinone; C024989:coenzyme Q10
keywords: Coenzyme Q10; Heart failure; Ubiquinol; Ubiquinone