title: Dynamic positron emission tomography restoration with low-rank representation incorporating edge preservation.
abstract: Dynamic positron emission tomography (PET) is a powerful tool that provides useful quantitative information on physiological and biochemical processes. However, the low signal-to-noise ratio (SNR) in short dynamic frames is a challenge.
  
  
  
  To get high SNR in the dynamic PET and to achieve high-quality PET parametric image are the objective of this study.
  
  
  
  Low-rank (LR) modeling and edge-preserving prior are incorporated in this study with a unified mathematical framework to improve the SNR of a dynamic PET image series. The proposed algorithm is designed to reduce noise in homogeneous areas while preserving the edges of regions of interest.
  
  
  
  The performance of the proposed method (LRH) is compared both visually and quantitatively by using the classic Gaussian filter and an LR expression filter on a digital brain phantom and in vivo rat study. Experimental results demonstrate that the proposed filter can achieve superior visual and quantitative performance without sacrificing spatial resolution.
  
  
  
  The proposed LRH is considerably effective and exhibits great potential in processing dynamic PET data with high noise levels.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Gao
authors.forename: Zhaoying
authors.initials: Z
authors.lastname: Bian
authors.forename: Benfu
authors.initials: B
authors.lastname: Li
authors.forename: Jie
authors.initials: J
authors.lastname: Peng
authors.forename: Lijun
authors.initials: L
authors.lastname: Lu
authors.forename: Jianhua
authors.initials: J
authors.lastname: Ma
authors.forename: Wufan
authors.initials: W
authors.lastname: Chen
mesh_terms: D000465:Algorithms; D001921:Brain / Q000000981:diagnostic imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008954:Models, Biological; D019047:Phantoms, Imaging; D049268:Positron-Emission Tomography / Q000379:methods*
keywords: Dynamic positron emission tomography; Huber prior; Low-rank modeling; image restoration