title: Flavonoid Glycosides and Their Derivatives from the Herbs of Scorzonera austriaca Wild.
abstract: Five flavonoid glycosides and two derivatives were isolated from the herbs of Scorzonera austriaca Wild by silica gel column chromatography and preparative HPLC. Their structures were identified, using chemical and spectroscopic methods, as 5,7,4'-trihydroxyflavone 6-C-(2''-O-β-d-glucopyranosyl β-d-glucopyranoside) (1), 5,7,3',4'-tetrahydroxyflavone 6-C-(2''-O-β-d-glucopyranosyl β-d-glucopyranoside) (2), quercetin 3-O-rutinoside (3), 5,7,4'-trihydroxyflavone 6-C-β-d-glucopyranoside (4), 3'-methoxy-5,7,4'-trihydroxyflavone 6-C-β-d-glucopyranoside (5), 5,7,4'-trihydroxyflavone 8-C-(6''-O-trans-caffeoyl β-d-glucopyranoside) (6), and 5,7,3',4'-tetrahydroxyflavone 8-C-(6''-O-trans-caffeoyl β-d-glucopyranoside) (7). Compounds 6 and 7 are new flavonoid glycoside derivatives, and compounds 1-5 were isolated from the herbs of Scorzonera austriaca for the first time. Compounds 6 and 7 were also assayed for their hepatoprotective activities with rat hepatocytes in vitro.
authors.affiliation: School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China. 13514486691@163.com.
authors.forename: Yang
authors.initials: Y
authors.lastname: Xie
authors.affiliation: Department of Pharmacy, the Second Part of First Hospital, Jilin University, Changchun 130021, China. guoqiushi126@126.com.
authors.forename: Qiu-Shi
authors.initials: QS
authors.lastname: Guo
authors.affiliation: School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China. wgs@jlu.edu.cn.
authors.forename: Guang-Shu
authors.initials: GS
authors.lastname: Wang
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D022781:Hepatocytes / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D051381:Rats; D012431:Rutin / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D031186:Scorzonera / Q000737:chemistry*
chemical_list: C427507:5,7,4'-trihydroxyflavone; D047309:Flavones; D005419:Flavonoids; D006027:Glycosides; D012431:Rutin
keywords: Scorzonera austriaca; flavonoids; hepatoprotective activities