title: Siladifluoromethylation and Difluoromethylation onto C(sp(3)), C(sp(2)), and C(sp) Centers Using Ruppert-Prakash Reagent and Fluoroform.
abstract: Siladifluoromethylations and difluoromethylations on sp(3), sp(2), and sp carbons of lithiated carbamates, arenes, and terminal alkynes, respectively, have been attained by employing the Ruppert-Prakash reagent (CF3TMS) and fluoroform (CF3H) as the CF2 sources. The advantage of this reaction is that the (sila)difluoromethylated compounds can be obtained by simple treatment of easily accessible substrates, lithium bases, and CF3TMS or CF3H. Furthermore, the products bearing the TMS group can be transformed into the valuable compounds with the CF2 fragment via the carbon-carbon bond forming reactions.
authors.affiliation: Department of Chemical Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute of Technology , O-okayama, Meguro-ku, Tokyo 152-8552, Japan.
authors.forename: Kohsuke
authors.initials: K
authors.lastname: Aikawa
authors.affiliation: Department of Chemical Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute of Technology , O-okayama, Meguro-ku, Tokyo 152-8552, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Maruyama
authors.affiliation: Department of Chemical Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute of Technology , O-okayama, Meguro-ku, Tokyo 152-8552, Japan.
authors.forename: Junki
authors.initials: J
authors.lastname: Nitta
authors.affiliation: Department of Chemical Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute of Technology , O-okayama, Meguro-ku, Tokyo 152-8552, Japan.
authors.forename: Ryota
authors.initials: R
authors.lastname: Hashimoto
authors.affiliation: Department of Chemical Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute of Technology , O-okayama, Meguro-ku, Tokyo 152-8552, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Mikami