title: Identification and analytical characterization of four synthetic cathinone derivatives iso-4-BMC, β-TH-naphyrone, mexedrone, and 4-MDMC.
abstract: New psychoactive substances (NPS) have gained much popularity on the global market over the last number of years. The synthetic cathinone family is one of the most prominent groups and this paper reports on the analytical properties of four synthetic cathinone derivatives: (1) 1-(4-bromophenyl)-1-(methylamino)propan-2-one (iso-4-BMC or iso-brephedrone), (2) 2-(pyrrolidin-1-yl)-1-(5,6,7,8-tetrahydronaphthalen-2-yl)pentan-1-one (β-TH-naphyrone), (3) 3-methoxy-2-(methylamino)-1-(4-methylphenyl)propan-1-one (mexedrone), and (4) 2-(dimethylamino)-1-(4-methylphenyl)propan-1-one (4-MDMC). These identifications were based on liquid chromatography-quadrupole time-of-flight-mass spectrometry (LC-QTOF-MS), gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance (NMR) spectroscopy. To our knowledge, no chemical or pharmacological data about compounds 1-3 have appeared until now, making this the first report on these compounds. The Raman and GC-MS data of 4 have been reported, but this study added the LC-MS and NMR data for additional characterization. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: National Narcotics Laboratory, Drug Intelligence and Forensic Center of the Ministry of Public Security, Beijing, China.
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Qian
authors.affiliation: National Narcotics Laboratory, Drug Intelligence and Forensic Center of the Ministry of Public Security, Beijing, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Jia
authors.affiliation: National Narcotics Laboratory, Drug Intelligence and Forensic Center of the Ministry of Public Security, Beijing, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.affiliation: National Narcotics Laboratory, Drug Intelligence and Forensic Center of the Ministry of Public Security, Beijing, China.
authors.forename: Cuimei
authors.initials: C
authors.lastname: Liu
authors.affiliation: National Narcotics Laboratory, Drug Intelligence and Forensic Center of the Ministry of Public Security, Beijing, China.
authors.forename: Zhendong
authors.initials: Z
authors.lastname: Hua
mesh_terms: D000470:Alkaloids / Q000032:analysis*; D002853:Chromatography, Liquid; D008401:Gas Chromatography-Mass Spectrometry; D013287:Illicit Drugs / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008694:Methamphetamine / Q000031:analogs & derivatives* / Q000032:analysis; D008744:Methylamines / Q000032:analysis*; D010422:Pentanones / Q000032:analysis*; D011208:Powders; D011407:Propane / Q000031:analogs & derivatives* / Q000032:analysis; D011759:Pyrrolidines / Q000032:analysis*
chemical_list: C000620745:1-(4-bromophenyl)-1-(methylamino)propan-2-one; C509270:1-naphthalen-2-yl-2-pyrrolidin-1-ylpentan-1-one; C000620746:2-(dimethylamino)-1-(4-methylphenyl)propan-1-one; D000470:Alkaloids; D013287:Illicit Drugs; D008744:Methylamines; D010422:Pentanones; D011208:Powders; D011759:Pyrrolidines; C000614728:mexedrone; D008694:Methamphetamine; C023665:cathinone; D011407:Propane
keywords: 4-MDMC; Mexedrone; iso-4-BMC; new psychoactive substance; synthetic cathinones; β-TH-naphyrone