title: Hemolytic Anemia and Heart Failure Caused by Anti-C and Anti-E Immunization.
abstract: Many different blood group systems, such as Rh, ABO, Kell, Kidd, Duffy, MNS, have been reported as causes of hemolytic disease of the newborn. Hemolysis due to minor blood group incompatibility in the fetus or newborn has been determined in isolated case reports. Here, we report a case of a patient who had received red cell transfusion due to severe Rh c and E incompatibility, leading to hemolytic anemia with heart failure. The mother and the baby were grouped B and B, respectively, both being positive for RhD antigen. The baby's blood group type was C+, c+, E+, e+, K-, while her mother's blood group type was C+, c-, E-, e+, K-. Our patient was diagnosed as Rh c and E incompatibility, leading to the hemolytic anemia. Minor blood group incompatibility should be considered in infants with prolonged jaundice and severe anemia, leading to heart failure.
authors.affiliation: Department of Pediatrics, Division of Neonatology, School of Medicine, Turgut Ozal University, Ankara, Turkey.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Bilgin
authors.affiliation: Department of Pediatrics, Division of Neonatology, School of Medicine, Turgut Ozal University, Ankara, Turkey.
authors.forename: Abdulkadir
authors.initials: A
authors.lastname: Eren
authors.affiliation: Department of Pediatrics, Division of Neonatology, School of Medicine, Turgut Ozal University, Ankara, Turkey.
authors.forename: Semra
authors.initials: S
authors.lastname: Kara
mesh_terms: D000743:Anemia, Hemolytic / Q000209:etiology* / Q000276:immunology; D001663:Bilirubin / Q000097:blood* / Q000276:immunology; D001787:Blood Group Incompatibility; D004899:Erythroblastosis, Fetal / Q000097:blood*; D017707:Erythrocyte Transfusion; D005260:Female; D006333:Heart Failure / Q000209:etiology* / Q000276:immunology; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D006932:Hyperbilirubinemia / Q000209:etiology* / Q000276:immunology; D007231:Infant, Newborn; D007518:Isoantibodies; D012203:Rh Isoimmunization
chemical_list: D006454:Hemoglobins; D007518:Isoantibodies; C051138:anti-c antibody; D001663:Bilirubin