title: [Histological grading of breast cancer].
abstract: From a historical perspective, histological grading was the earliest cell-based method for assessing tumor biology and the prognosis of breast cancer. This review article provides detailed and practical instructions for grading of breast cancer in routine diagnostics. Furthermore, the increasing relevance of precise histological grading in the era of molecular pathology is discussed.
authors.affiliation: Institut für Pathologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str.1, 30625, Hannover, Deutschland. Christgen.Matthias@MH-Hannover.de.
authors.forename: M
authors.initials: M
authors.lastname: Christgen
authors.affiliation: Institut für Pathologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str.1, 30625, Hannover, Deutschland.
authors.forename: F
authors.initials: F
authors.lastname: Länger
authors.affiliation: Institut für Pathologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str.1, 30625, Hannover, Deutschland.
authors.forename: H
authors.initials: H
authors.lastname: Kreipe
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000145:classification / Q000473:pathology* / Q000628:therapy; D018270:Carcinoma, Ductal, Breast / Q000145:classification / Q000473:pathology* / Q000628:therapy; D002467:Cell Nucleus / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis; D008870:Microtubules / Q000473:pathology; D008940:Mitotic Index; D060787:Neoplasm Grading / Q000379:methods; D009361:Neoplasm Invasiveness / Q000473:pathology; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen
keywords: Mitotic activity; Nuclear pleomorphism; Prognosis; Tubule formation; Tumor biology