title: Influencing fatty acid composition of yeasts by lanthanides.
abstract: The growth of microorganisms is affected by cultivation conditions, concentration of carbon and nitrogen sources and the presence of trace elements. One of the new possibilities of influencing the production of cell mass or lipids is the use of lanthanides. Lanthanides are biologically non-essential elements with wide applications in technology and industry and their concentration as environmental contaminants is therefore increasing. Although non-essential, lanthanides have been proposed (and even used) to produce beneficial effects in plants but their mechanisms of action are unclear. Recently, it was suggested that they may replace essential elements or operate as potent blockers of Ca(2+) channels. We tested the effect of low concentrations of lanthanides on traditional biotechnologically useful yeast species (Kluyveromyces polysporus, Saccharomyces cerevisiae, Torulospora delbrueckii), and species capable of high accumulation of lipids (Rhodotorula glutinis, Trichosporon cutaneum, Candida sp., Yarrowia lipolytica). Low concentrations of lanthanum and monazite were conducive to an increase in cell mass and lipids and also higher production of palmitoleic acid, commonly used in cosmetics and medicine, and ω6-linoleic acid which is a precursor of thromboxanes, prostaglandins and leucotrienes.
authors.affiliation: Department of Biotechnology, University of Chemistry and Technology Prague, Technická 5, 166 28, Prague 6, Czech Republic. irena.kolouchova@vscht.cz.
authors.forename: Irena
authors.initials: I
authors.lastname: Kolouchova
authors.affiliation: Institute of Microbiology, CAS, Vídeňská 1083, 142 20, Prague, Czech Republic.
authors.forename: Karel
authors.initials: K
authors.lastname: Sigler
authors.affiliation: Department of Biotechnology, University of Chemistry and Technology Prague, Technická 5, 166 28, Prague 6, Czech Republic.
authors.forename: Michal
authors.initials: M
authors.lastname: Zimola
authors.affiliation: Department of Biotechnology, University of Chemistry and Technology Prague, Technická 5, 166 28, Prague 6, Czech Republic.|Institute of Microbiology, CAS, Vídeňská 1083, 142 20, Prague, Czech Republic.
authors.forename: Tomas
authors.initials: T
authors.lastname: Rezanka
authors.affiliation: Department of Biotechnology, University of Chemistry and Technology Prague, Technická 5, 166 28, Prague 6, Czech Republic.
authors.forename: Olga
authors.initials: O
authors.lastname: Matatkova
authors.affiliation: Department of Biotechnology, University of Chemistry and Technology Prague, Technická 5, 166 28, Prague 6, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Masak
mesh_terms: D018533:Biomass; D003470:Culture Media / Q000737:chemistry; D005227:Fatty Acids / Q000096:biosynthesis*; D007218:Industrial Microbiology; D028581:Lanthanoid Series Elements / Q000494:pharmacology*; D050356:Lipid Metabolism / Q000187:drug effects; D015003:Yeasts / Q000187:drug effects / Q000254:growth & development*
chemical_list: D003470:Culture Media; D005227:Fatty Acids; D028581:Lanthanoid Series Elements
keywords: Fatty acids; Lanthanides; Microbial lipids; Non-oleaginous yeasts; Oleaginous yeasts