title: From Histones to RNA: Role of Methylation in Signal Proteins Involved in Adipogenesis.
abstract: New fat cells originate from a preexisting population of undifferentiated progenitor cells named preadipocytes. The process in which preadipocytes proliferate and differentiate into mature adipocytes under certain circumstances is called adipogenesis. In the past decade, many epigenetic factors have been shown to be pivotal for the appropriate timing of adipogenesis. A large number of coregulators at critical gene promoters set up specific patterns of DNA methylation, histone methylation and RNA methylation, which act as an epigenetic code to modulate the correct progress of adipocyte differentiation and adipogenesis. In this review, we focus on the functions and roles of epigenetic processes in preadipocyte differentiation and adipogenesis.
authors.affiliation: College of Animal Sciences, Zhejiang University, No. 866 Yuhangtang Road, Hangzhou, Zhejiang 310058. China.
authors.forename: Xinxia
authors.initials: X
authors.lastname: Wang
authors.affiliation: College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang 310058. China.
authors.forename: Yizhen
authors.initials: Y
authors.lastname: Wang
mesh_terms: D017667:Adipocytes / Q000166:cytology / Q000378:metabolism; D050156:Adipogenesis; D000818:Animals; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D053263:Gene Regulatory Networks; D042421:Histone Code; D006657:Histones / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008745:Methylation; D011401:Promoter Regions, Genetic; D012313:RNA / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D006657:Histones; D012313:RNA
keywords: DNA methylation; Histone methylation; RNA methylation; adipogenesis; demethylase; methyltransferase