title: Graphene/Nafion composite film modified glassy carbon electrode for simultaneous determination of paracetamol, aspirin and caffeine in pharmaceutical formulations.
abstract: A graphene-Nafion composite film was fabricated on the glassy carbon electrode (GR-NF/GCE), and used for simultaneous determination of paracetamol (PAR), aspirin (ASA) and caffeine (CAF). The electrochemical behaviors of PAR, ASA and CAF were investigated by cyclic voltammetry and square-wave adsorptive anodic stripping voltammetry. By using stripping one for simultaneous determination of PAR, ASA and CAF, their electrochemical oxidation peaks appeared at +0.64, 1.04 and 1.44V, and good linear current responses were obtained with the detection limits of 18ngmL(-1) (1.2×10(-9)M), 11.7ngmL(-1) (6.5×10(-8)M) and 7.3ngmL(-1) (3.8×10(-8)M), respectively. Finally, the proposed electrochemical sensor was successfully applied for quantifying PAR, ASA and CAF in commercial tablet formulations.
authors.affiliation: Yüzüncü Yıl University, Faculty of Pharmacy, Department of Analytical Chemistry, 65080 Van, Turkey.
authors.forename: Aydın
authors.initials: A
authors.lastname: Yiğit
authors.affiliation: Yüzüncü Yıl University, Faculty of Pharmacy, Department of Analytical Chemistry, 65080 Van, Turkey. Electronic address: yavuzyardim2002@yahoo.com.
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Yardım
authors.affiliation: Yüzüncü Yıl University, Faculty of Science, Department of Inorganic Chemistry, 65080 Van, Turkey.
authors.forename: Metin
authors.initials: M
authors.lastname: Çelebi
authors.affiliation: Batman University, Health Services Vocational College, 72100 Batman, Turkey.
authors.forename: Abdulkadir
authors.initials: A
authors.lastname: Levent
authors.affiliation: Yüzüncü Yıl University, Faculty of Science, Department of Analytical Chemistry, 65080 Van, Turkey. Electronic address: zuhresenturk@hotmail.com.
authors.forename: Zühre
authors.initials: Z
authors.lastname: Şentürk
mesh_terms: D000082:Acetaminophen / Q000032:analysis* / Q000737:chemistry; D001241:Aspirin / Q000032:analysis* / Q000737:chemistry; D002110:Caffeine / Q000032:analysis* / Q000737:chemistry; D002244:Carbon / Q000737:chemistry; D055664:Electrochemical Techniques; D004566:Electrodes; D005465:Fluorocarbon Polymers / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D015203:Reproducibility of Results; D013607:Tablets
chemical_list: D005465:Fluorocarbon Polymers; D013607:Tablets; D000082:Acetaminophen; C040402:perfluorosulfonic acid; D002110:Caffeine; D002244:Carbon; D006108:Graphite; D001241:Aspirin
keywords: Aspirin; Caffeine; Graphene-Nafion composite film modified glassy carbon electrode; Paracetamol; Pharmaceutical formulation