title: Enantioselective Nickel-Catalyzed anti-Carbometallative Cyclizations of Alkynyl Electrophiles Enabled by Reversible Alkenylnickel E/Z Isomerization.
abstract: Nickel-catalyzed additions of arylboronic acids to alkynes, followed by enantioselective cyclizations of the alkenylnickel species onto tethered ketones or enones, are reported. These reactions are reliant upon the formal anti-carbonickelation of the alkyne, which is postulated to occur by the reversible E/Z isomerization of an alkenylnickel species.
authors.affiliation: School of Chemistry, University of Nottingham , University Park, Nottingham NG7 2RD, United Kingdom.
authors.forename: Christopher
authors.initials: C
authors.lastname: Clarke
authors.affiliation: School of Chemistry, University of Nottingham , University Park, Nottingham NG7 2RD, United Kingdom.
authors.forename: Celia A
authors.initials: CA
authors.lastname: Incerti-Pradillos
authors.affiliation: School of Chemistry, University of Nottingham , University Park, Nottingham NG7 2RD, United Kingdom.
authors.forename: Hon Wai
authors.initials: HW
authors.lastname: Lam