title: Bisphenol A Sensors on Polyimide Fabricated by Laser Direct Writing for Onsite River Water Monitoring at Attomolar Concentration.
abstract: This work presents an aptamer-based, highly sensitive and specific sensor for atto- to femtomolar level detection of bisphenol A (BPA). Because of its widespread use in numerous products, BPA enters surface water from effluent discharges during its manufacture, use, and from waste landfill sites throughout the world. On-site measurement of BPA concentrations in water is important for evaluating compliance with water quality standards or environmental risk levels of the harmful compound in the environment. The sensor in this work is porous, conducting, interdigitated electrodes that are formed by laser-induced carbonization of flexible polyimide sheets. BPA-specific aptamer is immobilized on the electrodes as the probe, and its binding with BPA at the electrode surface is detected by capacitive sensing. The binding process is aided by ac electroosmotic effect that accelerates the transport of BPA molecules to the nanoporous graphene-like structured electrodes. The sensor achieved a limit of detection of 58.28 aM with a response time of 20 s. The sensor is further applied for recovery analysis of BPA spiked in surface water. This work provides an affordable platform for highly sensitive, real time, and field-deployable BPA surveillance critical to the evaluation of the ecological impact of BPA exposure.
authors.affiliation: Department of Electrical Engineering and Computer Science, The University of Tennessee , 1520 Middle Drive, Knoxville, Tennessee 37996, United States.
authors.forename: Cheng
authors.initials: C
authors.lastname: Cheng
authors.affiliation: Department of Mechanical, Aerospace and Biomedical Engineering, The University of Tennessee , 1512 Middle Drive, Knoxville, Tennessee 37996, United States.|College of Electronics and Information Engineering, Sichuan University , No. 24 South Section 1, Yihuan Road, Chengdu, 610065, PRC.
authors.forename: Shutong
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Electrical Engineering and Computer Science, The University of Tennessee , 1520 Middle Drive, Knoxville, Tennessee 37996, United States.
authors.forename: Jayne
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Mechanical, Aerospace and Biomedical Engineering, The University of Tennessee , 1512 Middle Drive, Knoxville, Tennessee 37996, United States.
authors.forename: Yongchao
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Department of Mechanical, Aerospace and Biomedical Engineering, The University of Tennessee , 1512 Middle Drive, Knoxville, Tennessee 37996, United States.
authors.forename: Ruozhou
authors.initials: R
authors.lastname: Li
authors.affiliation: Department of Forestry, Wildlife and Fisheries, The University of Tennessee Institute of Agriculture , 2431 Joe Johnson Drive, Knoxville, Tennessee 37996, United States.
authors.forename: Shigetoshi
authors.initials: S
authors.lastname: Eda
authors.affiliation: Department of Public Health, The University of Tennessee , 1914 Andy Holt Avenue, Knoxville, Tennessee 37996, United States.
authors.forename: Jiangang
authors.initials: J
authors.lastname: Chen
authors.affiliation: College of Electronics and Information Engineering, Sichuan University , No. 24 South Section 1, Yihuan Road, Chengdu, 610065, PRC.
authors.forename: Guoying
authors.initials: G
authors.lastname: Feng
authors.affiliation: Computing Science and Engineering Division, Oak Ridge National Laboratory , Oak Ridge, Tennessee 37831, United States.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Lawrie
authors.affiliation: Department of Mechanical, Aerospace and Biomedical Engineering, The University of Tennessee , 1512 Middle Drive, Knoxville, Tennessee 37996, United States.|Institute of Laser Engineering, Beijing University of Technology , 100 Pingleyuan, Chaoyang District, Beijing 100124, PRC.
authors.forename: Anming
authors.initials: A
authors.lastname: Hu
keywords: ac electroosmosis; aptasensor; capacitive sensing; laser direct writing; point of care