title: ABAEnrichment: an R package to test for gene set expression enrichment in the adult and developing human brain.
abstract: We present ABAEnrichment, an R package that tests for expression enrichment in specific brain regions at different developmental stages using expression information gathered from multiple regions of the adult and developing human brain, together with ontologically organized structural information about the brain, both provided by the Allen Brain Atlas. We validate ABAEnrichment by successfully recovering the origin of gene sets identified in specific brain cell-types and developmental stages.
  
  
  
  ABAEnrichment was implemented as an R package and is available under GPL (≥ 2) from the Bioconductor website (http://bioconductor.org/packages/3.3/bioc/html/ABAEnrichment.html).
  
  
  
  steffi_grote@eva.mpg.de, kelso@eva.mpg.de or michael_dannemann@eva.mpg.deSupplementary information: Supplementary data are available at Bioinformatics online.
authors.affiliation: Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany.
authors.forename: Steffi
authors.initials: S
authors.lastname: Grote
authors.affiliation: Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany.
authors.forename: Kay
authors.initials: K
authors.lastname: Prüfer
authors.affiliation: Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany.
authors.forename: Janet
authors.initials: J
authors.lastname: Kelso
authors.affiliation: Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany Medical Faculty, University of Leipzig, Leipzig 04103, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Dannemann
mesh_terms: D000328:Adult; D001921:Brain / Q000254:growth & development / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D012984:Software