title: A meta-analysis of biomarkers for the prognosis of triple-negative breast cancer patients.
abstract: Identification of biomarkers that has the ability to predict triple-negative breast cancer (TNBC) prognosis especially in patients undergoing chemotherapy is very important.
  
  
  METHODS
  The cohort studies that reported association between chemotherapy biomarker expression and survival outcome in TNBC patients were included in our analysis.
  
  
  RESULTS
  The promising markers that emerged for the prediction of disease-free survival and overall survival included Ki67, BRCA1 methylation and LC3B. Furthermore, Ki67 appeared to be also significantly associated with worse disease-free survival in TNBC patients who received anthracycline-based chemotherapy.
  
  
  CONCLUSIONS
  This meta-analysis demonstrated that in TNBC patients receiving chemotherapy, Ki67 is a predictor for poor prognosis, BRCA1 methylation and LC3B are also potential prognostic markers. In addition, the TNBC patients with high Ki67 expression seems to display resistance to anthracycline-based chemotherapy.
authors.affiliation: Breast Disease Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Gui
authors.affiliation: Breast Disease Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
authors.forename: Shuman
authors.initials: S
authors.lastname: Xu
authors.affiliation: Breast Disease Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Yang
authors.affiliation: Burn Research Institute, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.|National Key Laboratory of Trauma & Burns, Chongqing Key Lab. of Disease Proteomics, Chongqing, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Gu
authors.affiliation: Burn Research Institute, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.|National Key Laboratory of Trauma & Burns, Chongqing Key Lab. of Disease Proteomics, Chongqing, China.
authors.forename: Ze
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Burn Research Institute, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.|National Key Laboratory of Trauma & Burns, Chongqing Key Lab. of Disease Proteomics, Chongqing, China.
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Luo
authors.affiliation: Breast Disease Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.|National Key Laboratory of Trauma & Burns, Chongqing Key Lab. of Disease Proteomics, Chongqing, China.
authors.forename: Li
authors.initials: L
authors.lastname: Chen
mesh_terms: D018943:Anthracyclines / Q000627:therapeutic use; D019313:BRCA1 Protein / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism*; D016208:Databases, Factual; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D016016:Proportional Hazards Models; D015996:Survival Rate; D064726:Triple Negative Breast Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality
chemical_list: D018943:Anthracyclines; D019313:BRCA1 Protein; C492913:BRCA1 protein, human; D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; C502070:MAP1LC3B protein, human; D008869:Microtubule-Associated Proteins
keywords: biomarkers; chemotherapy; meta-analysis; prognosis; triple-negative breast cancer