title: Unexpected platelets elevation in a patient with idiopathic thrombocytopenia treated with oseltamivir for influenza infection.
abstract: Oseltamivir is a neuraminidase inhibitor approved for the prevention and treatment of influenza. Few haematological side effects have been reported with oseltamivir. We report herein the case of an unexpected platelet increase in a 46-year-old woman with idiopathic thrombocytopenia (ITP) treated with oseltamivir for influenza. The mechanism may involve the neuraminidase inhibition which decrease platelet surface sialic acid content and reduce their removal by the reticuloendothelial system. Oseltamivir may be responsible for platelet increase especially in patients with ITP.
authors.affiliation: Pharmacy Department, Valenciennes Hospital, Valenciennes, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Bigot
authors.affiliation: Regional pharmacovigilance center, Lille University Hospital, Lille, France. marine.auffret@chru-lille.fr.
authors.forename: Marine
authors.initials: M
authors.lastname: Auffret
authors.affiliation: Regional pharmacovigilance center, Lille University Hospital, Lille, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Gautier
authors.affiliation: Dermatology Department, Valenciennes Hospital, Valenciennes, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Weinborn
authors.affiliation: Infectious and Tropical Diseases Department, Valenciennes Hospital, Valenciennes, France.
authors.forename: Nicolas-Kader
authors.initials: NK
authors.lastname: Ettahar
authors.affiliation: Pharmacy Department, Valenciennes Hospital, Valenciennes, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Coupé
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D006801:Humans; D007251:Influenza, Human / Q000097:blood* / Q000150:complications / Q000188:drug therapy*; D008875:Middle Aged; D009439:Neuraminidase / Q000037:antagonists & inhibitors; D053139:Oseltamivir / Q000494:pharmacology / Q000627:therapeutic use*; D010976:Platelet Count / Q000379:methods; D013921:Thrombocytopenia / Q000097:blood* / Q000150:complications / Q000188:drug therapy*
chemical_list: D000998:Antiviral Agents; D053139:Oseltamivir; D009439:Neuraminidase
keywords: drug induced; idiopathic thrombocytopenia; influenza; oseltamivir; platelet count