title: Systems analysis of the prostate transcriptome in African-American men compared with European-American men.
abstract: African-Americans (AA) have increased prostate cancer risk and a greater mortality rate than European-Americans (EA). AA exhibit a high prevalence of vitamin D deficiency. We examined the global prostate transcriptome in AA and EA, and the effect of vitamin D3supplementation.
  
  
  
  Twenty-seven male subjects (ten AA and 17 EA), slated to undergo prostatectomy were enrolled in the study. Fourteen subjects received vitamin D3(4000 IU daily) and 13 subjects received placebo for 2 months prior to surgery.
  
  
  
  AA show higher expression of genes associated with immune response and inflammation.
  
  
  
  Systems level analyses support the concept that Inflammatory processes may contribute to disease progression in AA. These transcripts can be modulated by a short course of vitamin D3supplementation.
authors.affiliation: Department of Medicine & Public Health, Medical University of South Carolina, Charleston, SC, USA.|Center for Genomics Medicine, Medical University of South Carolina, Charleston, SC, USA.
authors.forename: Gary
authors.initials: G
authors.lastname: Hardiman
authors.affiliation: Department of Urology.|Ralph H Johnson VA Medical Center, Charleston, SC, USA.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Savage
authors.affiliation: Center for Genomics Medicine, Medical University of South Carolina, Charleston, SC, USA.|Library Science and Informatics, Medical University of South Carolina, Charleston, SC, USA.
authors.forename: E Starr
authors.initials: ES
authors.lastname: Hazard
authors.affiliation: Center for Genomics Medicine, Medical University of South Carolina, Charleston, SC, USA.|Department of Pathology & Laboratory Medicine, Medical University of South Carolina, Charleston, SC, USA.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Wilson
authors.affiliation: Center for Genomics Medicine, Medical University of South Carolina, Charleston, SC, USA.
authors.forename: Sean M
authors.initials: SM
authors.lastname: Courtney
authors.affiliation: Department of Pathology & Laboratory Medicine, Medical University of South Carolina, Charleston, SC, USA.
authors.forename: Michael T
authors.initials: MT
authors.lastname: Smith
authors.affiliation: Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.
authors.forename: Bruce W
authors.initials: BW
authors.lastname: Hollis
authors.affiliation: Ralph H Johnson VA Medical Center, Charleston, SC, USA.|Department of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA.
authors.forename: Chanita Hughes
authors.initials: CH
authors.lastname: Halbert
authors.affiliation: Ralph H Johnson VA Medical Center, Charleston, SC, USA.|Department of Radiation Oncology, Medical University of South Carolina, Charleston, SC, USA.
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Gattoni-Celli
mesh_terms: D001741:Black or African American / Q000235:genetics*; D000368:Aged; D002762:Cholecalciferol / Q000008:administration & dosage; D015331:Cohort Studies; D019587:Dietary Supplements; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011467:Prostate / Q000187:drug effects / Q000502:physiology* / Q000601:surgery; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000601:surgery; D013597:Systems Analysis; D059467:Transcriptome / Q000187:drug effects / Q000235:genetics*; D044465:White People / Q000235:genetics*
chemical_list: D002762:Cholecalciferol
keywords: African–American; RNA-seq; health disparities; prostate; transcription; vitamin D