title: Prognosis of Patients with Gestational Trophoblastic Neoplasia and Obstetric Outcomes of Those Conceiving After Chemotherapy.
abstract: OBJECTIVE
  To assess prognosis of gestational trophoblastic neoplasia (GTN) and obstetric outcome after chemotherapy.
  
  
  METHODS
  Sixty-six patients had diagnosis of hydatiform mole on curettage and 18 developed GTN. Two patients were referred with pathological diagnosis of GTN. Chemotherapy was tailored according to International Federation of Gynecology and Obstetrics risk scoring system.
  
  
  RESULTS
  All patients with GTN but one, were recovered by chemotherapy and had no evidence of disease after a median follow-up of 80 months. Only the patient with epithelioid trophoblastic tumor died of disease. Seven out of the eight women who tried to conceive after chemotherapy became pregnant. Ten conceptions occurred, resulting in no molar pregnancy, three miscarriages and seven term-live healthy births (70.0%). All seven babies showed normal development and growth after a median follow-up of 38 months.
  
  
  CONCLUSIONS
  The prognosis of women with GTN is very good, and obstetric outcomes of those who conceive after chemotherapy are similar to those of the general population.
authors.affiliation: Division of Gynecology and Obstetrics, Department of Clinical and Experimental Medicine, Division of Pathology, University of Pisa, Pisa, Italy a.gadducci@med.unipi.it.
authors.forename: Angiolo
authors.initials: A
authors.lastname: Gadducci
authors.affiliation: Division of Gynecology and Obstetrics, Department of Clinical and Experimental Medicine, Division of Pathology, University of Pisa, Pisa, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Cosio
authors.affiliation: Division of Gynecology and Obstetrics, Department of Clinical and Experimental Medicine, Division of Pathology, University of Pisa, Pisa, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Fanucchi
authors.affiliation: Division of Gynecology and Obstetrics, Department of Clinical and Experimental Medicine, Division of Pathology, University of Pisa, Pisa, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Tana
authors.affiliation: Division of Gynecology and Obstetrics, Department of Clinical and Experimental Medicine, Division of Pathology, University of Pisa, Pisa, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Manacorda
authors.affiliation: Translational Research and New Technologies in Medicine and Surgery, Division of Pathology, University of Pisa, Pisa, Italy.
authors.forename: Sabina
authors.initials: S
authors.lastname: Pistolesi
authors.affiliation: Division of Gynecology and Obstetrics, Department of Clinical and Experimental Medicine, Division of Pathology, University of Pisa, Pisa, Italy.
authors.forename: Francesca Letizia
authors.initials: FL
authors.lastname: Strigini
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D003609:Dactinomycin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D059247:Fertility Preservation; D031901:Gestational Trophoblastic Disease / Q000097:blood / Q000188:drug therapy* / Q000401:mortality; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D011247:Pregnancy; D011379:Prognosis; D047929:Term Birth; D016896:Treatment Outcome; D014594:Uterine Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000401:mortality; D055815:Young Adult
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human; D003609:Dactinomycin; D005047:Etoposide; D002955:Leucovorin; D008727:Methotrexate
keywords: Gestational trophoblastic neoplasia; choriocarcinoma; combination chemotherapy; epithelioid trophoblastic tumor; methotrexate; βhCG