title: Changes in expression of C2cd4c in pancreatic endocrine cells during pancreatic development.
abstract: C2cd4c, encoded by a gene belonging to the C2cd4 family, contains a C2 domain conserved across species and is localized to the cytoplasm. To examine the role of C2cd4c in the pancreas, we studied its localization and generated C2cd4c knockout (KO) mice. C2cd4c was expressed in pancreatic endocrine progenitors at early embryonic stages. When endocrine cells arise from their precursors, C2cd4c is gradually confined to the insulin- and pancreatic polypeptide-expressing cells of the endocrine. In the adult pancreas, C2cd4c is restricted to the beta cells. C2cd4c KO mice showed normal embryonic pancreatic development and adult pancreatic function. Thus, our results suggest that C2cd4c is dispensable for pancreatic development.
authors.affiliation: Institute of Molecular Embryology and Genetics, Kumamoto University, Japan.
authors.forename: Hisayoshi
authors.initials: H
authors.lastname: Omori
authors.affiliation: Institute of Molecular Embryology and Genetics, Kumamoto University, Japan.|Department of Life Science and Technology, School of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan.|Division of Pharmacology, National Institute of Health Science, Kamiyoga, Setagaya-ku, Tokyo, Japan.
authors.forename: Soichiro
authors.initials: S
authors.lastname: Ogaki
authors.affiliation: Institute of Molecular Embryology and Genetics, Kumamoto University, Japan.|Department of Life Science and Technology, School of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Sakano
authors.affiliation: Institute of Molecular Embryology and Genetics, Kumamoto University, Japan.
authors.forename: Mutsumi
authors.initials: M
authors.lastname: Sato
authors.affiliation: Institute of Molecular Embryology and Genetics, Kumamoto University, Japan.|HIGO program, Kumamoto University, Japan.
authors.forename: Kahoko
authors.initials: K
authors.lastname: Umeda
authors.affiliation: Division of Developmental Genetics, Institute of Resource Development and Analysis, Kumamoto University, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Takeda
authors.affiliation: Division of Reproductive Engineering, Institute of Resource Development and Analysis, Kumamoto University, Japan.
authors.forename: Naomi
authors.initials: N
authors.lastname: Nakagata
authors.affiliation: Institute of Molecular Embryology and Genetics, Kumamoto University, Japan.|Department of Life Science and Technology, School of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan.
authors.forename: Shoen
authors.initials: S
authors.lastname: Kume
mesh_terms: D000818:Animals; D002135:Calcium-Binding Proteins / Q000235:genetics*; D002454:Cell Differentiation / Q000235:genetics; D019070:Cell Lineage / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D007328:Insulin / Q000235:genetics / Q000378:metabolism*; D050417:Insulin-Secreting Cells / Q000378:metabolism; D007515:Islets of Langerhans / Q000254:growth & development / Q000378:metabolism*; D008565:Membrane Proteins / Q000096:biosynthesis* / Q000235:genetics; D051379:Mice; D018345:Mice, Knockout; D010179:Pancreas / Q000254:growth & development / Q000378:metabolism*
chemical_list: C000618324:C2cd4c protein, mouse; D002135:Calcium-Binding Proteins; D007328:Insulin; D008565:Membrane Proteins
keywords: C2cd4; insulin; pancreas; pancreatic beta cell