title: Letting post-marketing bridge the evidence gap: the case of orphan drugs.
authors.affiliation: IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy Pharmaceutical Department, Local Health Unit of Verona, Via Salvo D'Acquisto 7, 37122 Verona, Italy roberta.joppi@guest.marionegri.it.
authors.forename: Roberta
authors.initials: R
authors.lastname: Joppi
authors.affiliation: IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Gerardi
authors.affiliation: IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
authors.forename: Vittorio
authors.initials: V
authors.lastname: Bertele'
authors.affiliation: IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
authors.forename: Silvio
authors.initials: S
authors.lastname: Garattini
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000188:drug therapy*; D018268:Adrenocortical Carcinoma / Q000188:drug therapy*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D001471:Barrett Esophagus / Q000188:drug therapy; D017338:Cladribine / Q000627:therapeutic use; D017323:Dihematoporphyrin Ether / Q000627:therapeutic use; D004374:Ductus Arteriosus, Patent / Q000188:drug therapy; D006527:Hepatolenticular Degeneration / Q000188:drug therapy; D006801:Humans; D007052:Ibuprofen / Q000627:therapeutic use; D007943:Leukemia, Hairy Cell / Q000188:drug therapy; D008939:Mitotane / Q000627:therapeutic use; D009965:Orphan Drug Production; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011358:Product Surveillance, Postmarketing; D011799:Quinazolines / Q000627:therapeutic use; D013920:Thrombocythemia, Essential / Q000188:drug therapy; D019345:Zinc Acetate / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D018931:Antineoplastic Agents, Hormonal; D010975:Platelet Aggregation Inhibitors; D011799:Quinazolines; D017338:Cladribine; D008939:Mitotane; D017323:Dihematoporphyrin Ether; D019345:Zinc Acetate; C021139:anagrelide; D007052:Ibuprofen