title: [Increased serum levels of soluble T cell immunoglobulin mucin molecule 3 and IL-4 and decreased IFN-γ in patients with pulmonary tuberculosis].
abstract: Objective To detect the serum levels of soluble T cell immunoglobulin mucin molecule 3 (sTim-3), IFN-γ and IL-4 in patients with pulmonary tuberculosis. Methods Peripheral blood was collected from 48 patients with pulmonary tuberculosis and 20 healthy controls. The serum level of sTim-3 was detected by ELISA. The levels of IFN-γ and IL-4 were determined by cytokine bead array (CBA). The correlations between sTim-3, IFN-γ and IL-4 levels in sera of patients with pulmonary tuberculosis were analyzed by Pearson correlation test. Results Compared with the control group, the serum levels of sTim-3 and IL-4 increased significantly, while the level of IFN-γ decreased significantly. Pearson analysis showed that there was a negative correlation between sTim-3 and IFN-γ as well as between IFN-γ and IL-4 in patients with pulmonary tuberculosis, while sTim-3 and IL-4 were positively correlated. Conclusion The serum levels of sTim-3 and IL-4 increase, but IFN-γ decreases in the patients with pulmonary tuberculosis.
authors.affiliation: First Affiliated Hospital, Department of Immunology, School of Preclinical Medicine, Xinjiang Medical University, Urumqi 830011, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Zhang
authors.affiliation: First Affiliated Hospital, School of Preclinical Medicine, Xinjiang Medical University, Urumqi 830011, China.
authors.forename: Fengbo
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Department of Immunology, School of Preclinical Medicine, Xinjiang Medical University, Urumqi 830011, China.
authors.forename: Qifeng
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Immunology, School of Preclinical Medicine, Xinjiang Medical University, Urumqi 830011, China.
authors.forename: Yunjuan
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Kashi Tuberculosis Prevention and Control Institute, Kashi 844000, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Guo
authors.affiliation: Department of Basic Medical Sciences, Jilin Medical University, Jilin 130021, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Li
authors.affiliation: First Affiliated Hospital, School of Preclinical Medicine, Xinjiang Medical University, Urumqi 830011, China. *Corresponding authors, E-mail: djbing002@sina.com.
authors.forename: Yu
authors.initials: Y
authors.lastname: Xia
authors.affiliation: First Affiliated Hospital, School of Preclinical Medicine, Xinjiang Medical University, Urumqi 830011, China. *Corresponding authors, E-mail: 46568653@qq.com.
authors.forename: Jianbing
authors.initials: J
authors.lastname: Ding
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D000072597:Hepatitis A Virus Cellular Receptor 2 / Q000097:blood*; D006801:Humans; D007371:Interferon-gamma / Q000097:blood*; D015847:Interleukin-4 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012995:Solubility; D014397:Tuberculosis, Pulmonary / Q000097:blood*; D055815:Young Adult
chemical_list: C448908:HAVCR2 protein, human; D000072597:Hepatitis A Virus Cellular Receptor 2; D015847:Interleukin-4; D007371:Interferon-gamma