title: Synthesis of an Iridoid-Inspired Compound Collection and Discovery of Autophagy Inhibitors.
abstract: Iridoids comprise a large group of monoterpenoid natural products displaying a diverse array of biological activities ranging from neurotrophic to anti-inflammatory and anti-tumorigenic properties. Therefore, the development of concise synthesis routes to compound collections inspired by the structural features of these natural products is of particular relevance for chemical biology and medicinal chemistry. Herein we describe a samarium diiodide-mediated synthesis of a small, focused iridoid-inspired compound collection. Characterization of these iridoid analogues in biological assays revealed novel small-molecule inhibitors of autophagy.
authors.affiliation: Max Planck Institute of Molecular Physiology , Otto-Hahn-Straße 11, 44227 Dortmund, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Schröder
authors.affiliation: Faculty of Chemistry and Chemical Biology, Technical University Dortmund , Otto-Hahn-Straßa 6, 44221 Dortmund, Germany.
authors.forename: Jonathan O
authors.initials: JO
authors.lastname: Bauer
authors.affiliation: Faculty of Chemistry and Chemical Biology, Technical University Dortmund , Otto-Hahn-Straßa 6, 44221 Dortmund, Germany.
authors.forename: Carsten
authors.initials: C
authors.lastname: Strohmann
authors.affiliation: Max Planck Institute of Molecular Physiology , Otto-Hahn-Straße 11, 44227 Dortmund, Germany.
authors.forename: Kamal
authors.initials: K
authors.lastname: Kumar
authors.affiliation: Max Planck Institute of Molecular Physiology , Otto-Hahn-Straße 11, 44227 Dortmund, Germany.|Faculty of Chemistry and Chemical Biology, Technical University Dortmund , Otto-Hahn-Straßa 6, 44221 Dortmund, Germany.
authors.forename: Herbert
authors.initials: H
authors.lastname: Waldmann
mesh_terms: D001343:Autophagy / Q000187:drug effects*; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D055808:Drug Discovery; D039823:Iridoids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D001688:Biological Products; D039823:Iridoids