title: Cytototoxic constituents from the bark of Chisocheton cumingianus (Meliaceae).
abstract: A new lanostane-type triterpenoid, 3β-hydroxy-25-ethyl-lanost-9(11),24(24')-diene (1), along with 3β-hydroxy-lanost-7-ene (2) and β-sitosterol-3-O-acetate (3) was isolated from the stem bark of C. cumingianus. The chemical structure of the new compound was elucidated on the basis of spectroscopic data. All of the compounds were evaluated for their cytotoxic effects against P-388 murine leukemia cells. Compounds 1-3 showed cytotoxicity against P-388 murine leukemia cells with IC50values of 28.8 ± 0.10, 4.29 ± 0.03, and 100.18 ± 0.16 μg/ml, respectively.
authors.affiliation: a Faculty of Mathematics and Natural Sciences, Department of Chemistry , Universitas Padjadjaran , Jatinangor 45363 , Indonesia.|b Faculty of Mathematics and Natural Sciences, Department of Chemistry , Universitas Sam Ratulangi , Manado 95115 , Indonesia.
authors.forename: Dewa Gede
authors.initials: DG
authors.lastname: Katja
authors.affiliation: a Faculty of Mathematics and Natural Sciences, Department of Chemistry , Universitas Padjadjaran , Jatinangor 45363 , Indonesia.
authors.forename: Kindi
authors.initials: K
authors.lastname: Farabi
authors.affiliation: a Faculty of Mathematics and Natural Sciences, Department of Chemistry , Universitas Padjadjaran , Jatinangor 45363 , Indonesia.
authors.lastname: Nurlelasari
authors.affiliation: a Faculty of Mathematics and Natural Sciences, Department of Chemistry , Universitas Padjadjaran , Jatinangor 45363 , Indonesia.
authors.forename: Desi
authors.initials: D
authors.lastname: Harneti
authors.affiliation: a Faculty of Mathematics and Natural Sciences, Department of Chemistry , Universitas Padjadjaran , Jatinangor 45363 , Indonesia.
authors.forename: Tri
authors.initials: T
authors.lastname: Mayanti
authors.affiliation: a Faculty of Mathematics and Natural Sciences, Department of Chemistry , Universitas Padjadjaran , Jatinangor 45363 , Indonesia.
authors.forename: Unang
authors.initials: U
authors.lastname: Supratman
authors.affiliation: c Faculty of Science, Department of Chemistry , University of Malaya , Kuala Lumpur 59100 , Malaysia.
authors.forename: Khalijah
authors.initials: K
authors.lastname: Awang
authors.affiliation: d Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences , Osaka Prefecture University , Osaka 599-8531 , Japan.
authors.forename: Hideo
authors.initials: H
authors.lastname: Hayashi
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D007810:Lanosterol / Q000031:analogs & derivatives; D007941:Leukemia P388; D029582:Meliaceae / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry*; D012855:Sitosterols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: C000616056:3beta-hydroxy-25-ethyl-lanost-9(11),24(24')-diene; C000616058:3beta-hydroxy-lanost-7-ene; D000972:Antineoplastic Agents, Phytogenic; D012855:Sitosterols; D014315:Triterpenes; C000616060:beta-sitosterol-3-O-acetate; D007810:Lanosterol
keywords: Chisocheton cumingianus; Lanostane-type triterpenoid; Meliaceae; cytotoxic activity