title: Acute promyelocytic leukemia co-existing with JAK2 V617F positive myeloproliferative neoplasm: a case report.
abstract: The V617F mutation of Janus-associated kinase 2 (JAK2) is commonly seen in myeloproliferative neoplasms (MPN). Transformation of JAK2 positive MPNs to acute leukemia has been reported. We here report a case of acute promyelocytic leukemia which was later confirmed to have a co-existing JAK2 V617F positive MPN. In addition, the patient was found to have FLT3-TKD mutation, which, together with PML/RARa, could play a role in the MPN transformation to APL.
authors.affiliation: 1 Department of Medicine, Westchester Medical Center and New York Medical College, Valhalla, NY 10595, USA ; 2 Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China ; 3 Department of Pathology, Westchester Medical Center and New York Medical College, Valhalla, NY 10595, USA.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Mamorska-Dyga
authors.affiliation: 1 Department of Medicine, Westchester Medical Center and New York Medical College, Valhalla, NY 10595, USA ; 2 Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China ; 3 Department of Pathology, Westchester Medical Center and New York Medical College, Valhalla, NY 10595, USA.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Wu
authors.affiliation: 1 Department of Medicine, Westchester Medical Center and New York Medical College, Valhalla, NY 10595, USA ; 2 Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China ; 3 Department of Pathology, Westchester Medical Center and New York Medical College, Valhalla, NY 10595, USA.
authors.forename: Pallavi
authors.initials: P
authors.lastname: Khattar
authors.affiliation: 1 Department of Medicine, Westchester Medical Center and New York Medical College, Valhalla, NY 10595, USA ; 2 Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China ; 3 Department of Pathology, Westchester Medical Center and New York Medical College, Valhalla, NY 10595, USA.
authors.forename: Faisal M H
authors.initials: FM
authors.lastname: Ronny
authors.affiliation: 1 Department of Medicine, Westchester Medical Center and New York Medical College, Valhalla, NY 10595, USA ; 2 Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China ; 3 Department of Pathology, Westchester Medical Center and New York Medical College, Valhalla, NY 10595, USA.
authors.forename: Humayun
authors.initials: H
authors.lastname: Islam
authors.affiliation: 1 Department of Medicine, Westchester Medical Center and New York Medical College, Valhalla, NY 10595, USA ; 2 Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China ; 3 Department of Pathology, Westchester Medical Center and New York Medical College, Valhalla, NY 10595, USA.
authors.forename: Karen
authors.initials: K
authors.lastname: Seiter
authors.affiliation: 1 Department of Medicine, Westchester Medical Center and New York Medical College, Valhalla, NY 10595, USA ; 2 Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China ; 3 Department of Pathology, Westchester Medical Center and New York Medical College, Valhalla, NY 10595, USA.
authors.forename: Delong
authors.initials: D
authors.lastname: Liu
keywords: Acute myelogenous leukemia (APL); Janus-associated kinase 2 (JAK2); PML/RARa; myeloproliferative neoplasms (MPN)