title: [Hyperbaric oxygen and radiotherapy: From myth to reality].
abstract: Worldwide, more than a million people receive each year a curative radiotherapy. While local control and overall survival are steadily increasing, 5 to 15% of patients still develop above grade 2 late toxicities. Late toxicities treatments are complex. Hyperbaric oxygenation was shown to induce revascularization and healing of injured tissues, but indications are still debated. Through a literature review, we summarized the hyperbaric oxygenation indications in radiation-induced late toxicities. We also studied the knowledge and practice of French local radiation therapists. It seems that hyperbaric oxygen therapy can be a conservative treatment of haemorrhagic cystitis and radiation-induced pain, in case of drug therapies failure. Often associated with a significant morbidity and mortality, surgery could be avoided. The risk of complications in case of tooth extraction in irradiated tissues is also reduced. However, the role of hyperbaric oxygenation for mandibular osteoradionecrosis, radiation-induced proctitis, enteritis, lymphoedema, brachial plexopathy, skin and neurological sequelae seems more questionable since studies results are conflicting. Future outcomes of phase III studies are expected to clarify the role of hyperbaric oxygenation in the management of radio-induced toxicities, including for head and necks complications.
authors.affiliation: Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex, France.
authors.forename: S
authors.initials: S
authors.lastname: Espenel
authors.affiliation: Département de médecine hyperbare, hôpital Édouard-Herriot, 5, place d'Arsonval, 69003 Lyon, France.
authors.forename: C
authors.initials: C
authors.lastname: Raffoux
authors.affiliation: Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex, France.
authors.forename: A
authors.initials: A
authors.lastname: Vallard
authors.affiliation: Département de santé publique, centre Hygée, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex, France.
authors.forename: M-A
authors.initials: MA
authors.lastname: Garcia
authors.affiliation: Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex, France.
authors.forename: J-B
authors.initials: JB
authors.lastname: Guy
authors.affiliation: Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex, France.
authors.forename: C
authors.initials: C
authors.lastname: Rancoule
authors.affiliation: Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex, France.
authors.forename: M
authors.initials: M
authors.lastname: Ben Mrad
authors.affiliation: Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex, France.
authors.forename: J
authors.initials: J
authors.lastname: Langrand-Escure
authors.affiliation: Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex, France.
authors.forename: J-C
authors.initials: JC
authors.lastname: Trone
authors.affiliation: Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex, France.
authors.forename: G
authors.initials: G
authors.lastname: Pigne
authors.affiliation: Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex, France.
authors.forename: P
authors.initials: P
authors.lastname: Diao
authors.affiliation: Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex, France. Electronic address: nicolas.magne@icloire.fr.
authors.forename: N
authors.initials: N
authors.lastname: Magné
mesh_terms: D020516:Brachial Plexus Neuropathies / Q000209:etiology / Q000628:therapy; D003072:Cognition Disorders / Q000209:etiology / Q000628:therapy; D003556:Cystitis / Q000628:therapy; D004751:Enteritis / Q000209:etiology / Q000628:therapy; D006801:Humans; D006931:Hyperbaric Oxygenation; D008209:Lymphedema / Q000209:etiology / Q000628:therapy; D008336:Mandibular Diseases / Q000628:therapy; D010025:Osteoradionecrosis / Q000628:therapy; D011349:Proctitis / Q000209:etiology / Q000628:therapy; D011855:Radiodermatitis / Q000628:therapy; D011878:Radiotherapy / Q000009:adverse effects*; D014081:Tooth Extraction
keywords: Complications; Hyperbaric oxygenation; Oxygénothérapie hyperbare; Radiotherapy; Radiothérapie; Toxicity; Toxicité tardive