title: Functional Photoacoustic Imaging of Gastric Acid Secretion Using pH-Responsive Polyaniline Nanoprobes.
abstract: A stomach functional imaging technique based on photoacoustics achieves noninvasive gastric acid secretory assessment utilizing pH-responsive polyaniline nanoprobes. A testing protocol mimicking clinical practice is established using a mouse model. After imaging, the nanoprobes are excreted outside the body without inducing systematic toxicity. Further optimization and translation of this technology can help alleviate patients' suffering and side effects.
authors.affiliation: Department of Bioengineering, University of Washington, Seattle, WA, 98195, USA.
authors.forename: Junwei
authors.initials: J
authors.lastname: Li
authors.affiliation: PCFM Lab of Ministry of Education School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, 510275, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Xiao
authors.affiliation: Department of Bioengineering, University of Washington, Seattle, WA, 98195, USA.
authors.forename: Soon Joon
authors.initials: SJ
authors.lastname: Yoon
authors.affiliation: Shenzhen Key Lab for Molecular Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China.
authors.forename: Chengbo
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Bioengineering, University of Washington, Seattle, WA, 98195, USA.
authors.forename: Drew
authors.initials: D
authors.lastname: Matsuura
authors.affiliation: Department of Bioengineering, University of Washington, Seattle, WA, 98195, USA.
authors.forename: Wanyi
authors.initials: W
authors.lastname: Tai
authors.affiliation: Shenzhen Key Lab for Molecular Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China. liang.song@siat.ac.cn.
authors.forename: Liang
authors.initials: L
authors.lastname: Song
authors.affiliation: Department of Bioengineering, University of Washington, Seattle, WA, 98195, USA. odonnel@uw.edu.
authors.forename: Matthew
authors.initials: M
authors.lastname: O'Donnell
authors.affiliation: PCFM Lab of Ministry of Education School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, 510275, China. chengdu@mail.sysu.edu.cn.
authors.forename: Du
authors.initials: D
authors.lastname: Cheng
authors.affiliation: Department of Bioengineering, University of Washington, Seattle, WA, 98195, USA. xgao@uw.edu.
authors.forename: Xiaohu
authors.initials: X
authors.lastname: Gao
mesh_terms: D000284:Administration, Oral; D000814:Aniline Compounds / Q000737:chemistry*; D000818:Animals; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D021621:Imaging, Three-Dimensional; D058185:Magnetite Nanoparticles / Q000008:administration & dosage / Q000737:chemistry* / Q000633:toxicity; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D061088:Photoacoustic Techniques / Q000379:methods*
chemical_list: D000814:Aniline Compounds; D058185:Magnetite Nanoparticles; C416807:polyaniline
keywords: gastric acid secretory assessment; nanoparticles; nanoprobes; photoacoustic imaging; polyaniline; stomach imaging