title: [Analysis of Clinical Characteristics in 10 Patietns with T Large Granular Lymphocytic Leukemia].
abstract: OBJECTIVE
  To analyze the clinical manifestations and laboratory features of patients with T large granular lymphocytic leukemia (T-LGLL), so as to improve the understanding of this disease.
  
  
  METHODS
  The clinical data of 10 patients with T-LGLL in General Hospital of Chinese PLA from October 2015 to March 2010 were analyzed retrospectively.
  
  
  RESULTS
  Their median age at diagnosis was 51 years old. 9/10 (90%) patients showed symptoms of anemia, with a median Hb level of 82.5 g/L, 5/10 (50%) patients combined with autoimmune disorders and with a median Hb level of 77 g/L. 7/10 (70%) patients had splenomegaly, 2/10 (20%) patients had complex karyotype, 2/10 (20%) patients had gene mutations, the median age of 4 patients with complex karyotype and gene mutation was 49 years old, all of them suffered from splenomegaly. The immunophenotype of 6/10 patients was CD3+ CD4- CD8+ and that of 2/10 patients (20%) was CD3+ CD4- CD8-, that of another 2/10 (20%) was CD3+ CD4+ CD8-, the clinical features between different types of immunization were not statistically different.
  
  
  CONCLUSIONS
  T-LGLL patients often are old men, combined with anemia and splenomegaly, often associated with autoimmune diseases; the patients with complex karyotype and gene mutation are younger and they are more with hepatosplenomegaly; the guide role of different immunotypes for clinical strategy is no significant.
authors.affiliation: Department of Hematology, Chinese PLA General Hosipital, Beijing 100853, China.
authors.forename: An-Qi
authors.initials: AQ
authors.lastname: Liu
authors.affiliation: Department of Hematology, Chinese PLA General Hosipital, Beijing 100853, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Hematology, Chinese PLA General Hosipital, Beijing 100853, China.
authors.forename: Yong-Hui
authors.initials: YH
authors.lastname: Li
authors.affiliation: Department of Hematology, Chinese PLA General Hosipital, Beijing 100853, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Jing
authors.affiliation: Department of Hematology, Chinese PLA General Hosipital, Beijing 100853, China.
authors.forename: Shu-Hong
authors.initials: SH
authors.lastname: Wang
authors.affiliation: Department of Hematology, Chinese PLA General Hosipital, Beijing 100853, China.
authors.forename: Jun-Hui
authors.initials: JH
authors.lastname: Mei
authors.affiliation: Department of Hematology, Chinese PLA General Hosipital, Beijing 100853, China.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Dou
authors.affiliation: Department of Hematology, Chinese PLA General Hosipital, Beijing 100853, China.
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Wang
authors.affiliation: Department of Hematology, Chinese PLA General Hosipital, Beijing 100853, China. E-mail: chunhuiliyu@yahoo.com.
authors.forename: Li
authors.initials: L
authors.lastname: Yu
mesh_terms: D000740:Anemia / Q000473:pathology; D001327:Autoimmune Diseases / Q000473:pathology; D002869:Chromosome Aberrations; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D016130:Immunophenotyping; D054066:Leukemia, Large Granular Lymphocytic / Q000175:diagnosis* / Q000473:pathology; D008875:Middle Aged; D012189:Retrospective Studies; D013154:Spleen / Q000473:pathology
chemical_list: D006454:Hemoglobins