title: Effect of time and body position on ventilation in premature infants.
abstract: Infants with respiratory dysfunction undergo regular position changes to improve lung function however it is not known how often a position change should occur. This study measured changes in lung function occurring over time after repositioning in preterm infants.
  
  
  
  Changes in end-expiratory level (EEL) and ventilation distribution were measured 30 mins, 2 h, and 4 h after repositioning into either prone, quarter turn from prone, or supine using Electrical Impedance Tomography (EIT). Physiological measurements were also taken.
  
  
  
  Sixty preterm infants were included in the study. Infants receiving respiratory support (mechanical ventilation or continuous positive airway pressure (CPAP)) had improved ventilation homogeneity after 2 h (P < 0.01), maintained at 4 h. Spontaneously breathing infants had improved homogeneity at 2 h (P < 0.01) and improved global EEL after 4 h (P < 0.01) whereas infants receiving CPAP demonstrated an improved global EEL at 2 h (P < 0.01).
  
  
  
  Regional ventilation distribution is influenced by time independent of changes due to body position. Differences exist between infants on ventilatory support compared with those who are spontaneously breathing. Infants receiving ventilatory support have a physiological peak in lung function after 2 h which remains above baseline at 4 h. A change in body position facilitates an improvement in lung function in infants on ventilatory support.
authors.affiliation: School of Physiotherapy, Australian Catholic University, Banyo, Australia.|Mater Research Institute - The University of Queensland, South Brisbane, Australia.
authors.forename: Judith
authors.initials: J
authors.lastname: Hough
authors.affiliation: School of Physiotherapy, Australian Catholic University, Banyo, Australia.
authors.forename: Anthony
authors.initials: A
authors.lastname: Trojman
authors.affiliation: Mater Research Institute - The University of Queensland, South Brisbane, Australia.
authors.forename: Andreas
authors.initials: A
authors.lastname: Schibler
mesh_terms: D045422:Continuous Positive Airway Pressure; D018592:Cross-Over Studies; D017097:Electric Impedance; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D015931:Intensive Care, Neonatal; D008168:Lung / Q000502:physiology; D008297:Male; D016684:Prone Position / Q000502:physiology*; D011793:Queensland; D012119:Respiration; D012121:Respiration, Artificial / Q000379:methods*; D012129:Respiratory Function Tests; D012307:Risk Factors; D016683:Supine Position / Q000502:physiology*; D013990:Tidal Volume; D013997:Time Factors; D014054:Tomography