title: Factors predictive of critical value of hypocalcemia after total parathyroidectomy without autotransplantation in patients with secondary hyperparathyroidism.
abstract: BACKGROUND
  Severe hypocalcemia is the most dangerous complication occurring after total parathyroidectomy without autotransplantation (TPTX) for secondary hyperparathyroidism (SHPT). We aim to identify the prevalence and potential risk factors of very severe hypocalcemia in patients with SHPT undergoing TPTX.
  
  
  METHODS
  From April 2012 to August 2015, 157 patients with SHPT undergoing TPTX were reviewed. The critical value of hypocalcemia (CVH) was postoperative serum Ca(2+) levels of ≤1.5 mmol/L.
  
  
  RESULTS
  Univariate analysis showed that patients in the CVH group were significantly younger than those in the non-CVH group. Sex ratio was significantly different between the two groups. The CVH group had significantly higher levels of preoperative PTH and ALP. Male sex and preoperative levels of PTH and ALP were significant independent risk factors by logistic regression analysis.
  
  
  CONCLUSIONS
  Male sex, preoperative PTH and ALP were significantly associated with CVH in patients with SHPT undergoing TPTX.
authors.affiliation: a Department of Breast and Thyroid Surgery , China-Japan Friendship Hospital , Beijing , China ;
authors.forename: Meng
authors.initials: M
authors.lastname: Yang
authors.affiliation: b Department of Nephrology , China-Japan Friendship Hospital , Beijing , China.
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
authors.affiliation: a Department of Breast and Thyroid Surgery , China-Japan Friendship Hospital , Beijing , China ;
authors.forename: Linping
authors.initials: L
authors.lastname: Huang
authors.affiliation: a Department of Breast and Thyroid Surgery , China-Japan Friendship Hospital , Beijing , China ;
authors.forename: Xiaoliang
authors.initials: X
authors.lastname: Sun
authors.affiliation: a Department of Breast and Thyroid Surgery , China-Japan Friendship Hospital , Beijing , China ;
authors.forename: Haoyang
authors.initials: H
authors.lastname: Ji
authors.affiliation: a Department of Breast and Thyroid Surgery , China-Japan Friendship Hospital , Beijing , China ;
authors.forename: Yao
authors.initials: Y
authors.lastname: Lu
mesh_terms: D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D002118:Calcium / Q000097:blood; D002681:China; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000601:surgery*; D006996:Hypocalcemia / Q000453:epidemiology* / Q000209:etiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D016105:Parathyroidectomy / Q000009:adverse effects*; D011183:Postoperative Complications / Q000453:epidemiology*; D012008:Recurrence; D051436:Renal Insufficiency, Chronic / Q000150:complications*; D012307:Risk Factors; D012737:Sex Factors; D014182:Transplantation, Autologous; D016896:Treatment Outcome
chemical_list: D010281:Parathyroid Hormone; D000469:Alkaline Phosphatase; D002118:Calcium
keywords: Chronic kidney disease; hypocalcemia; risk factors; secondary hyperparathyroidism; total parathyroidectomy without autotransplantation