title: Association of Aortic Stiffness With Left Ventricular Remodeling and Reduced Left Ventricular Function Measured by Magnetic Resonance Imaging: The Multi-Ethnic Study of Atherosclerosis.
abstract: BACKGROUND
  This study sought to assess cross-sectional associations of aortic stiffness assessed by magnetic resonance imaging with left ventricular (LV) remodeling and myocardial deformation in the Multi-Ethnic Study of Atherosclerosis (MESA).
  
  
  RESULTS
  Aortic arch pulse wave velocity (PWV) was measured with phase contrast cine magnetic resonance imaging. LV circumferential strain (Ecc), torsion, and early diastolic strain rate were determined by tagged magnetic resonance imaging. Multivariable linear regression models were used to adjust for demographics and cardiovascular risk factors. Of 2093 participants, multivariable linear regression models demonstrated that higher arch PWV was associated with higher LV mass index (B=0.53 per 1 SD increase for log-transformed PWV, P<0.05) and LV mass to volume ratio (B=0.015, P<0.01), impaired LV ejection fraction (LVEF; B=-0.84; P<0.001), Ecc (B=0.55; P<0.001), torsion (B=-0.11; P<0.001), and early diastolic strain rate (B=-0.003; P<0.05). In sex stratified analysis, higher arch PWV was associated with higher MVR (B=0.02; P<0.05), impaired Ecc (B=0.60; P<0.001), and LVEF (B=-0.45; P<0.05), but with maintained torsion in women. Higher PWV was associated with impaired Ecc (B=0.49; P<0.001) and LVEF (B=-1.21; P<0.001), with lower torsion (B=-0.17; P<0.001) in men.
  
  
  CONCLUSIONS
  Higher arch PWV is associated with LV remodeling, and reduced LV systolic and diastolic function in a large multiethnic population. Greater aortic arch stiffness is associated with concentric LV remodeling and relatively preserved LVEF with maintained torsion in women, whereas greater aortic arch stiffness is associated with greater LV dysfunction demonstrated as impaired Ecc, torsion, and LVEF, with less concentric LV remodeling in men.
authors.affiliation: From the Department of Cardiology (Y.O., C.N., A.R.C., G.T.-T., J.-Y.K., S.D., K.Y., O.G., J.A.C.L.), Department of Radiology (B.A.-V.), Johns Hopkins University, Baltimore, MD; Department of Cardiology, Hospital General Universitari Vall d'Herbron, Barcelona, Spain (G.T.-T.); Department of Cardiology, Oslo University Hospital, Norway (O.G.); Imagerie Cardiovasculaire/Cardiovascular Imaging DICVRI, Institut de Cardiologie, Groupe Hospitalier Pitié Salpêtrière, Paris, France (A.R.); National Institutes of Health Clinical Center, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD (C.-Y.L., D.A.B.); Clinical Investigation and Research Unit, Gunma University, Maebashi, Japan (T.N.); Office of Biostatistics Research, National Heart, Lung and Blood Institute, Bethesda, MD (C.O.W.); and Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC (W.G.H.).
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ohyama
authors.affiliation: From the Department of Cardiology (Y.O., C.N., A.R.C., G.T.-T., J.-Y.K., S.D., K.Y., O.G., J.A.C.L.), Department of Radiology (B.A.-V.), Johns Hopkins University, Baltimore, MD; Department of Cardiology, Hospital General Universitari Vall d'Herbron, Barcelona, Spain (G.T.-T.); Department of Cardiology, Oslo University Hospital, Norway (O.G.); Imagerie Cardiovasculaire/Cardiovascular Imaging DICVRI, Institut de Cardiologie, Groupe Hospitalier Pitié Salpêtrière, Paris, France (A.R.); National Institutes of Health Clinical Center, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD (C.-Y.L., D.A.B.); Clinical Investigation and Research Unit, Gunma University, Maebashi, Japan (T.N.); Office of Biostatistics Research, National Heart, Lung and Blood Institute, Bethesda, MD (C.O.W.); and Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC (W.G.H.).
authors.forename: Bharath
authors.initials: B
authors.lastname: Ambale-Venkatesh
authors.affiliation: From the Department of Cardiology (Y.O., C.N., A.R.C., G.T.-T., J.-Y.K., S.D., K.Y., O.G., J.A.C.L.), Department of Radiology (B.A.-V.), Johns Hopkins University, Baltimore, MD; Department of Cardiology, Hospital General Universitari Vall d'Herbron, Barcelona, Spain (G.T.-T.); Department of Cardiology, Oslo University Hospital, Norway (O.G.); Imagerie Cardiovasculaire/Cardiovascular Imaging DICVRI, Institut de Cardiologie, Groupe Hospitalier Pitié Salpêtrière, Paris, France (A.R.); National Institutes of Health Clinical Center, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD (C.-Y.L., D.A.B.); Clinical Investigation and Research Unit, Gunma University, Maebashi, Japan (T.N.); Office of Biostatistics Research, National Heart, Lung and Blood Institute, Bethesda, MD (C.O.W.); and Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC (W.G.H.).
authors.forename: Chikara
authors.initials: C
authors.lastname: Noda
authors.affiliation: From the Department of Cardiology (Y.O., C.N., A.R.C., G.T.-T., J.-Y.K., S.D., K.Y., O.G., J.A.C.L.), Department of Radiology (B.A.-V.), Johns Hopkins University, Baltimore, MD; Department of Cardiology, Hospital General Universitari Vall d'Herbron, Barcelona, Spain (G.T.-T.); Department of Cardiology, Oslo University Hospital, Norway (O.G.); Imagerie Cardiovasculaire/Cardiovascular Imaging DICVRI, Institut de Cardiologie, Groupe Hospitalier Pitié Salpêtrière, Paris, France (A.R.); National Institutes of Health Clinical Center, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD (C.-Y.L., D.A.B.); Clinical Investigation and Research Unit, Gunma University, Maebashi, Japan (T.N.); Office of Biostatistics Research, National Heart, Lung and Blood Institute, Bethesda, MD (C.O.W.); and Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC (W.G.H.).
authors.forename: Atul R
authors.initials: AR
authors.lastname: Chugh
authors.affiliation: From the Department of Cardiology (Y.O., C.N., A.R.C., G.T.-T., J.-Y.K., S.D., K.Y., O.G., J.A.C.L.), Department of Radiology (B.A.-V.), Johns Hopkins University, Baltimore, MD; Department of Cardiology, Hospital General Universitari Vall d'Herbron, Barcelona, Spain (G.T.-T.); Department of Cardiology, Oslo University Hospital, Norway (O.G.); Imagerie Cardiovasculaire/Cardiovascular Imaging DICVRI, Institut de Cardiologie, Groupe Hospitalier Pitié Salpêtrière, Paris, France (A.R.); National Institutes of Health Clinical Center, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD (C.-Y.L., D.A.B.); Clinical Investigation and Research Unit, Gunma University, Maebashi, Japan (T.N.); Office of Biostatistics Research, National Heart, Lung and Blood Institute, Bethesda, MD (C.O.W.); and Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC (W.G.H.).
authors.forename: Gisela
authors.initials: G
authors.lastname: Teixido-Tura
authors.affiliation: From the Department of Cardiology (Y.O., C.N., A.R.C., G.T.-T., J.-Y.K., S.D., K.Y., O.G., J.A.C.L.), Department of Radiology (B.A.-V.), Johns Hopkins University, Baltimore, MD; Department of Cardiology, Hospital General Universitari Vall d'Herbron, Barcelona, Spain (G.T.-T.); Department of Cardiology, Oslo University Hospital, Norway (O.G.); Imagerie Cardiovasculaire/Cardiovascular Imaging DICVRI, Institut de Cardiologie, Groupe Hospitalier Pitié Salpêtrière, Paris, France (A.R.); National Institutes of Health Clinical Center, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD (C.-Y.L., D.A.B.); Clinical Investigation and Research Unit, Gunma University, Maebashi, Japan (T.N.); Office of Biostatistics Research, National Heart, Lung and Blood Institute, Bethesda, MD (C.O.W.); and Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC (W.G.H.).
authors.forename: Jang-Young
authors.initials: JY
authors.lastname: Kim
authors.affiliation: From the Department of Cardiology (Y.O., C.N., A.R.C., G.T.-T., J.-Y.K., S.D., K.Y., O.G., J.A.C.L.), Department of Radiology (B.A.-V.), Johns Hopkins University, Baltimore, MD; Department of Cardiology, Hospital General Universitari Vall d'Herbron, Barcelona, Spain (G.T.-T.); Department of Cardiology, Oslo University Hospital, Norway (O.G.); Imagerie Cardiovasculaire/Cardiovascular Imaging DICVRI, Institut de Cardiologie, Groupe Hospitalier Pitié Salpêtrière, Paris, France (A.R.); National Institutes of Health Clinical Center, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD (C.-Y.L., D.A.B.); Clinical Investigation and Research Unit, Gunma University, Maebashi, Japan (T.N.); Office of Biostatistics Research, National Heart, Lung and Blood Institute, Bethesda, MD (C.O.W.); and Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC (W.G.H.).
authors.forename: Sirisha
authors.initials: S
authors.lastname: Donekal
authors.affiliation: From the Department of Cardiology (Y.O., C.N., A.R.C., G.T.-T., J.-Y.K., S.D., K.Y., O.G., J.A.C.L.), Department of Radiology (B.A.-V.), Johns Hopkins University, Baltimore, MD; Department of Cardiology, Hospital General Universitari Vall d'Herbron, Barcelona, Spain (G.T.-T.); Department of Cardiology, Oslo University Hospital, Norway (O.G.); Imagerie Cardiovasculaire/Cardiovascular Imaging DICVRI, Institut de Cardiologie, Groupe Hospitalier Pitié Salpêtrière, Paris, France (A.R.); National Institutes of Health Clinical Center, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD (C.-Y.L., D.A.B.); Clinical Investigation and Research Unit, Gunma University, Maebashi, Japan (T.N.); Office of Biostatistics Research, National Heart, Lung and Blood Institute, Bethesda, MD (C.O.W.); and Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC (W.G.H.).
authors.forename: Kihei
authors.initials: K
authors.lastname: Yoneyama
authors.affiliation: From the Department of Cardiology (Y.O., C.N., A.R.C., G.T.-T., J.-Y.K., S.D., K.Y., O.G., J.A.C.L.), Department of Radiology (B.A.-V.), Johns Hopkins University, Baltimore, MD; Department of Cardiology, Hospital General Universitari Vall d'Herbron, Barcelona, Spain (G.T.-T.); Department of Cardiology, Oslo University Hospital, Norway (O.G.); Imagerie Cardiovasculaire/Cardiovascular Imaging DICVRI, Institut de Cardiologie, Groupe Hospitalier Pitié Salpêtrière, Paris, France (A.R.); National Institutes of Health Clinical Center, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD (C.-Y.L., D.A.B.); Clinical Investigation and Research Unit, Gunma University, Maebashi, Japan (T.N.); Office of Biostatistics Research, National Heart, Lung and Blood Institute, Bethesda, MD (C.O.W.); and Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC (W.G.H.).
authors.forename: Ola
authors.initials: O
authors.lastname: Gjesdal
authors.affiliation: From the Department of Cardiology (Y.O., C.N., A.R.C., G.T.-T., J.-Y.K., S.D., K.Y., O.G., J.A.C.L.), Department of Radiology (B.A.-V.), Johns Hopkins University, Baltimore, MD; Department of Cardiology, Hospital General Universitari Vall d'Herbron, Barcelona, Spain (G.T.-T.); Department of Cardiology, Oslo University Hospital, Norway (O.G.); Imagerie Cardiovasculaire/Cardiovascular Imaging DICVRI, Institut de Cardiologie, Groupe Hospitalier Pitié Salpêtrière, Paris, France (A.R.); National Institutes of Health Clinical Center, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD (C.-Y.L., D.A.B.); Clinical Investigation and Research Unit, Gunma University, Maebashi, Japan (T.N.); Office of Biostatistics Research, National Heart, Lung and Blood Institute, Bethesda, MD (C.O.W.); and Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC (W.G.H.).
authors.forename: Alban
authors.initials: A
authors.lastname: Redheuil
authors.affiliation: From the Department of Cardiology (Y.O., C.N., A.R.C., G.T.-T., J.-Y.K., S.D., K.Y., O.G., J.A.C.L.), Department of Radiology (B.A.-V.), Johns Hopkins University, Baltimore, MD; Department of Cardiology, Hospital General Universitari Vall d'Herbron, Barcelona, Spain (G.T.-T.); Department of Cardiology, Oslo University Hospital, Norway (O.G.); Imagerie Cardiovasculaire/Cardiovascular Imaging DICVRI, Institut de Cardiologie, Groupe Hospitalier Pitié Salpêtrière, Paris, France (A.R.); National Institutes of Health Clinical Center, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD (C.-Y.L., D.A.B.); Clinical Investigation and Research Unit, Gunma University, Maebashi, Japan (T.N.); Office of Biostatistics Research, National Heart, Lung and Blood Institute, Bethesda, MD (C.O.W.); and Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC (W.G.H.).
authors.forename: Chia-Ying
authors.initials: CY
authors.lastname: Liu
authors.affiliation: From the Department of Cardiology (Y.O., C.N., A.R.C., G.T.-T., J.-Y.K., S.D., K.Y., O.G., J.A.C.L.), Department of Radiology (B.A.-V.), Johns Hopkins University, Baltimore, MD; Department of Cardiology, Hospital General Universitari Vall d'Herbron, Barcelona, Spain (G.T.-T.); Department of Cardiology, Oslo University Hospital, Norway (O.G.); Imagerie Cardiovasculaire/Cardiovascular Imaging DICVRI, Institut de Cardiologie, Groupe Hospitalier Pitié Salpêtrière, Paris, France (A.R.); National Institutes of Health Clinical Center, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD (C.-Y.L., D.A.B.); Clinical Investigation and Research Unit, Gunma University, Maebashi, Japan (T.N.); Office of Biostatistics Research, National Heart, Lung and Blood Institute, Bethesda, MD (C.O.W.); and Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC (W.G.H.).
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Nakamura
authors.affiliation: From the Department of Cardiology (Y.O., C.N., A.R.C., G.T.-T., J.-Y.K., S.D., K.Y., O.G., J.A.C.L.), Department of Radiology (B.A.-V.), Johns Hopkins University, Baltimore, MD; Department of Cardiology, Hospital General Universitari Vall d'Herbron, Barcelona, Spain (G.T.-T.); Department of Cardiology, Oslo University Hospital, Norway (O.G.); Imagerie Cardiovasculaire/Cardiovascular Imaging DICVRI, Institut de Cardiologie, Groupe Hospitalier Pitié Salpêtrière, Paris, France (A.R.); National Institutes of Health Clinical Center, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD (C.-Y.L., D.A.B.); Clinical Investigation and Research Unit, Gunma University, Maebashi, Japan (T.N.); Office of Biostatistics Research, National Heart, Lung and Blood Institute, Bethesda, MD (C.O.W.); and Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC (W.G.H.).
authors.forename: Colin O
authors.initials: CO
authors.lastname: Wu
authors.affiliation: From the Department of Cardiology (Y.O., C.N., A.R.C., G.T.-T., J.-Y.K., S.D., K.Y., O.G., J.A.C.L.), Department of Radiology (B.A.-V.), Johns Hopkins University, Baltimore, MD; Department of Cardiology, Hospital General Universitari Vall d'Herbron, Barcelona, Spain (G.T.-T.); Department of Cardiology, Oslo University Hospital, Norway (O.G.); Imagerie Cardiovasculaire/Cardiovascular Imaging DICVRI, Institut de Cardiologie, Groupe Hospitalier Pitié Salpêtrière, Paris, France (A.R.); National Institutes of Health Clinical Center, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD (C.-Y.L., D.A.B.); Clinical Investigation and Research Unit, Gunma University, Maebashi, Japan (T.N.); Office of Biostatistics Research, National Heart, Lung and Blood Institute, Bethesda, MD (C.O.W.); and Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC (W.G.H.).
authors.forename: W Gregory
authors.initials: WG
authors.lastname: Hundley
authors.affiliation: From the Department of Cardiology (Y.O., C.N., A.R.C., G.T.-T., J.-Y.K., S.D., K.Y., O.G., J.A.C.L.), Department of Radiology (B.A.-V.), Johns Hopkins University, Baltimore, MD; Department of Cardiology, Hospital General Universitari Vall d'Herbron, Barcelona, Spain (G.T.-T.); Department of Cardiology, Oslo University Hospital, Norway (O.G.); Imagerie Cardiovasculaire/Cardiovascular Imaging DICVRI, Institut de Cardiologie, Groupe Hospitalier Pitié Salpêtrière, Paris, France (A.R.); National Institutes of Health Clinical Center, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD (C.-Y.L., D.A.B.); Clinical Investigation and Research Unit, Gunma University, Maebashi, Japan (T.N.); Office of Biostatistics Research, National Heart, Lung and Blood Institute, Bethesda, MD (C.O.W.); and Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC (W.G.H.).
authors.forename: David A
authors.initials: DA
authors.lastname: Bluemke
authors.affiliation: From the Department of Cardiology (Y.O., C.N., A.R.C., G.T.-T., J.-Y.K., S.D., K.Y., O.G., J.A.C.L.), Department of Radiology (B.A.-V.), Johns Hopkins University, Baltimore, MD; Department of Cardiology, Hospital General Universitari Vall d'Herbron, Barcelona, Spain (G.T.-T.); Department of Cardiology, Oslo University Hospital, Norway (O.G.); Imagerie Cardiovasculaire/Cardiovascular Imaging DICVRI, Institut de Cardiologie, Groupe Hospitalier Pitié Salpêtrière, Paris, France (A.R.); National Institutes of Health Clinical Center, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD (C.-Y.L., D.A.B.); Clinical Investigation and Research Unit, Gunma University, Maebashi, Japan (T.N.); Office of Biostatistics Research, National Heart, Lung and Blood Institute, Bethesda, MD (C.O.W.); and Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC (W.G.H.). jlima@jhmi.edu.
authors.forename: Joao A C
authors.initials: JA
authors.lastname: Lima
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001013:Aorta, Thoracic / Q000000981:diagnostic imaging* / Q000503:physiopathology; D050197:Atherosclerosis / Q000000981:diagnostic imaging* / Q000208:ethnology / Q000503:physiopathology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D011237:Predictive Value of Tests; D011379:Prognosis; D063177:Pulse Wave Analysis; D012737:Sex Factors; D013318:Stroke Volume; D054159:Torsion, Mechanical; D014481:United States / Q000453:epidemiology; D059289:Vascular Stiffness; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000208:ethnology / Q000503:physiopathology; D016277:Ventricular Function, Left; D020257:Ventricular Remodeling
keywords: epidemiology; heart ventricles; magnetic resonance imaging; pulse wave analysis; vascular stiffness