title: Multimetallic catalysed radical oxidative C(sp(3))-H/C(sp)-H cross-coupling between unactivated alkanes and terminal alkynes.
abstract: Radical involved transformations are now considered as extremely important processes in modern organic synthetic chemistry. According to the demand by atom-economic and sustainable chemistry, direct C(sp(3))-H functionalization through radical oxidative coupling represents an appealing strategy for C-C bond formations. However, the selectivity control of reactive radical intermediates is still a great challenge in these transformations. Here we show a selective radical oxidative C(sp(3))-H/C(sp)-H cross-coupling of unactivated alkanes with terminal alkynes by using a combined Cu/Ni/Ag catalytic system. It provides a new way to access substituted alkynes from readily available materials. Preliminary mechanistic studies suggest that this reaction proceeds through a radical process and the C(sp(3))-H bond cleavage is the rate-limiting step. This study may have significant implications for controlling selective C-C bond formation of reactive radical intermediates by using multimetallic catalytic systems.
authors.affiliation: College of Chemistry and Molecular Sciences, Institute for Advanced Studies (IAS), Wuhan University, Wuhan 430072, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Tang
authors.affiliation: College of Chemistry and Molecular Sciences, Institute for Advanced Studies (IAS), Wuhan University, Wuhan 430072, China.
authors.forename: Pan
authors.initials: P
authors.lastname: Wang
authors.affiliation: College of Chemistry and Molecular Sciences, Institute for Advanced Studies (IAS), Wuhan University, Wuhan 430072, China.
authors.forename: Haoran
authors.initials: H
authors.lastname: Li
authors.affiliation: College of Chemistry and Molecular Sciences, Institute for Advanced Studies (IAS), Wuhan University, Wuhan 430072, China.|National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang 330022, China.
authors.forename: Aiwen
authors.initials: A
authors.lastname: Lei