title: Acute hematologic, hepatologic, and nephrologic changes after intraperitoneal injections of 18 nm gold nanoparticles in hamsters.
abstract: In vivo responses to gold nanoparticles (GNPs) vary not only according to the size, shape, surface charge, and capping agent of GNPs but also according to the animal model, the route of administration, and the exposure frequency and duration. We illustrate here the changes in some hematologic parameters, in the hepatic and renal functions, and in the histopathology of solid organs after multiple intraperitoneal injections of 18 nm GNPs in adult male Syrian golden hamsters. We scored the histopathological changes in the liver and kidneys to grade the deleterious effects. Multiple intraperitoneal injections of 18 nm GNPs in hamsters were nonlethal in the short term but resulted in macrocytosis and hypochromasia, leukocytosis, neutrophilia, lymphocytosis, and monocytosis. The hepatic and renal functions showed nonsignificant changes; however, histopathological examination showed hepatic and renal alterations ranging from mild to marked degeneration, with occasional necrosis of hepatocytes and tubular epithelium.
authors.affiliation: Otolaryngology Unit, Department of Medical Applications, The National Institute of Laser Enhanced Sciences, Cairo University, Guiza, Egypt.
authors.forename: Hazem Mohamed
authors.initials: HM
authors.lastname: Saleh
authors.affiliation: Department of Clinical Pathology, Cairo University, Guiza, Egypt.
authors.forename: Omar A
authors.initials: OA
authors.lastname: Soliman
authors.affiliation: Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Guiza, Egypt.
authors.forename: Mohamed Osama
authors.initials: MO
authors.lastname: Elshazly
authors.affiliation: Department of Clinical Pathology, Cairo University, Guiza, Egypt.
authors.forename: Alaa
authors.initials: A
authors.lastname: Raafat
authors.affiliation: Department of Clinical Pathology, Cairo University, Guiza, Egypt.
authors.forename: Adel K
authors.initials: AK
authors.lastname: Gohar
authors.affiliation: Nanotechnology & Advanced Materials Central Laboratory, Agricultural Research Center, Guiza, Egypt.
authors.forename: Taher A
authors.initials: TA
authors.lastname: Salaheldin
mesh_terms: D000818:Animals; D006046:Gold / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D022781:Hepatocytes / Q000187:drug effects / Q000473:pathology; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D007964:Leukocytosis / Q000139:chemically induced; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008647:Mesocricetus; D053768:Metal Nanoparticles / Q000008:administration & dosage* / Q000009:adverse effects / Q000737:chemistry; D009336:Necrosis / Q000139:chemically induced / Q000473:pathology; D014018:Tissue Distribution
chemical_list: D006046:Gold
keywords: acute; hamsters; in vivo; nanogold