title: [Nephrolithiasis of adult: From mechanisms to preventive medical treatment].
abstract: Nephrolithiasis is a very common (prevalence around 10 to 12% in France) and recurrent disorder. Nephrolithiasis is associated to chronic kidney disease and is responsible for 2 to 3% of cases of end-stage renal disease, mainly if it is associated to nephrocalcinosis or to a monogenic disorder (1.6% of nephrolithiasis in adults, among them 1% of cystinuria). To understand the underlying pathophysiological processes, stone analysis (morphology and using infrared spectrophotometry) as well as minimal biological assessment including urine crystal research are required. The calcic nephrolithiasis is the more frequent subtype (>80%). Its medical treatment relies on simple dietary rules: non-alkaline hyperdiuresis>2 liters/day, calcium intake normalization (1 gram per day divided between the three principal meals), normalization of sodium (6 to 7 grams per day) and protein intake (1g/kg of theoretical body weight/day), and eviction of foods rich in oxalate. In case of persistent hypercalciuria (>0.1mmol/kg of theoretical body weight/day on free diet), a thiazide diuretic can be started while being aware to correct iatrogenic decrease in plasma potassium and urine citrate excretion. Measurement of bone mineral density must systematically be performed in patients with high 24 h-urinary calcium excretion. The medical treatment of uric acid nephrolithiasis relies on alkaline hyperdiuresis (goal of urine pH: 6.2 to 6.8). The use of allopurinol is justified only if urine uric acid is over 4mmol/day. Thanks to a well-managed preventive medical treatment, one can expect to stop the activity of nephrolithiasis in more than 80% of cases, making it one of the most accessible renal pathologies to preventive medical treatment.
authors.affiliation: Service de physiologie-explorations fonctionnelles, hôpital européen Georges-Pompidou, AP-HP, 20, rue Leblanc, 75015 Paris, France; Université Paris Descartes, 75006 Paris, France; Inserm U1151, CNRS UMR 8253, institut Necker-Enfants-Malades, 75015 Paris, France. Electronic address: marie.courbebaisse@aphp.fr.
authors.forename: M
authors.initials: M
authors.lastname: Courbebaisse
authors.affiliation: Service de physiologie-explorations fonctionnelles, hôpital européen Georges-Pompidou, AP-HP, 20, rue Leblanc, 75015 Paris, France; Université Paris Descartes, 75006 Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Prot-Bertoye
authors.affiliation: Service de physiologie-explorations fonctionnelles, hôpital européen Georges-Pompidou, AP-HP, 20, rue Leblanc, 75015 Paris, France; Université Paris Descartes, 75006 Paris, France.
authors.forename: J-P
authors.initials: JP
authors.lastname: Bertocchio
authors.affiliation: Service de physiologie-explorations fonctionnelles, hôpital européen Georges-Pompidou, AP-HP, 20, rue Leblanc, 75015 Paris, France; Université Paris Descartes, 75006 Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Baron
authors.affiliation: Service de physiologie-explorations fonctionnelles, hôpital européen Georges-Pompidou, AP-HP, 20, rue Leblanc, 75015 Paris, France; Inserm U1151, CNRS UMR 8253, institut Necker-Enfants-Malades, 75015 Paris, France.
authors.forename: G
authors.initials: G
authors.lastname: Maruani
authors.affiliation: Service de diététique, hôpital européen Georges-Pompidou, AP-HP, 75015 Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Briand
authors.affiliation: Service de physiologie-explorations fonctionnelles, hôpital Tenon, AP-HP, 75020 Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Daudon
authors.affiliation: Service de physiologie-explorations fonctionnelles, hôpital européen Georges-Pompidou, AP-HP, 20, rue Leblanc, 75015 Paris, France; Université Paris Descartes, 75006 Paris, France; Unité Inserm UMR_S1138, CNRS ERL8228, 75006 Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Houillier
mesh_terms: D000328:Adult; D002136:Calcium, Dietary / Q000008:administration & dosage; D005602:France / Q000453:epidemiology; D006801:Humans; D007669:Kidney Calculi / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control*; D007676:Kidney Failure, Chronic / Q000150:complications / Q000453:epidemiology / Q000628:therapy; D053040:Nephrolithiasis / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control*; D012307:Risk Factors; D014527:Uric Acid / Q000652:urine
chemical_list: D002136:Calcium, Dietary; D014527:Uric Acid
keywords: Acide urique; Calcium; Cysteine; Cystine; Lithiase rénale; Nephrolithiasis; Oxalate; Struvite; Uric acid