title: Release of cetyl pyridinium chloride from fatty acid chelate temporary dental cement.
abstract: ObjectiveTo determine whether the antimicrobial nature of a fatty acid chelate temporary dental cement can be enhanced by the addition of 5% cetyl pyridinium chloride (CPC).Materials and methodsThe temporary cement, Cavex Temporary was employed, and additions of CPC were made to either the base or the catalyst paste prior to mixing the cement. Release of CPC from set cement specimens was followed using reverse-phase HPLC for a period of up to 2 weeks following specimen preparation. Potential interactions between Cavex and CPC were examined by Fourier transform infrared spectroscopy (FTIR) and antimicrobial effects were determined using zone of inhibition measurements after 24 h with disc-shaped specimens in culturedStreptococcus mutans.ResultsFTIR showed no interaction between CPC and the components of the cement. CPC release was found to follow a diffusion mechanism for the first 6 h or so, and to equilibrate after approximately 2 weeks, with no significant differences between release profiles when the additive was incorporated into the base or the catalyst paste. Diffusion was rapid, and had a diffusion coefficient of approximately 1 × 10-9m2s-1in both cases. Total release was in the range 10-12% of the CPC loading. Zones of inhibition around discs containing CPC were significantly larger than those around the control discs of CPC-free cement.ConclusionsThe antimicrobial character of this temporary cement can be enhanced by the addition of CPC. Such enhancement is of potential clinical value, though furtherin vivowork is needed to confirm this.
authors.affiliation: Department of Pharmaceutical, Chemical & Environmental Sciences, University of Greenwich , Medway Campus, Chatham, Kent , UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Hurt
authors.affiliation: Department of Pharmaceutical, Chemical & Environmental Sciences, University of Greenwich , Medway Campus, Chatham, Kent , UK.
authors.forename: Nichola J
authors.initials: NJ
authors.lastname: Coleman
authors.affiliation: Department of Paediatric Dentistry, Faculty of Dentistry, Karadiniez Technical University , Trabzon , Turkey.
authors.forename: Tamer
authors.initials: T
authors.lastname: Tüzüner
authors.affiliation: Department of Prosthodontics, İzmir Katip Çelebi University, Faculty of Dentistry , Izmir , Turkey.
authors.forename: Bora
authors.initials: B
authors.lastname: Bagis
authors.affiliation: Department of Prosthodontics, Faculty of Dentistry, Karadiniez Technical University , Trabzon , Turkey.
authors.forename: Fatih Mehmet
authors.initials: FM
authors.lastname: Korkmaz
authors.affiliation: Bluefield Centre for Biomaterials , London , UK.
authors.forename: John W
authors.initials: JW
authors.lastname: Nicholson
keywords: FTIR; HPLC; Temporary cement; antimicrobial; cetyl pyridinium chloride; diffusion