title: Trends in ExPEC serogroups in the UK and their significance.
abstract: Extra-intestinal pathogenic Escherichia coli are a significant cause of urinary tract infection and bacteraemia within the UK. We sought to identify the serogroups of 658 E. coli isolates collected in the UK between January 2011 and March 2012, to better understand the ExPEC population and understand the relevance of serogroups in this pathotype. Isolates were typed and serogroup identified using established phenotypic and molecular methods. Sixty-two serogroups were identified; 54 among urinary isolates and 35 among bloodstream isolates. However, serogroups O25, O6, and O2 dominated both infection types. These serogroups were linked to the major ExPEC STs as follows: ST131-O25, ST73-O6, ST127-O6, and ST95-O2. The serogroup data from this study have increased our understanding of the ExPEC population in the UK, but also highlighted key ST-serogroup relationships within the major ExPEC clones. These data can be used to guide vaccine design and in the development of laboratory diagnostic tests targeting the ExPEC population.
authors.affiliation: Antimicrobial Research Group, Centre for Immunology and Infectious Disease, Blizard Institute, Bart's and the London School of Medicine and Dentistry, Queen Mary, University of London, E1 2AT, London, UK. h.ciesielczuk@nhs.net.|Antimicrobial Resistance and Healthcare Associated Infections (AMRHAI) Reference Unit, Public Health England, Colindale, UK. h.ciesielczuk@nhs.net.
authors.forename: H
authors.identifier: http://orcid.org/0000-0002-0003-1670
authors.initials: H
authors.lastname: Ciesielczuk
authors.affiliation: Gastrointestinal Bacteria Reference Unit, Public Health England, Colindale, UK.
authors.forename: C
authors.initials: C
authors.lastname: Jenkins
authors.affiliation: Gastrointestinal Bacteria Reference Unit, Public Health England, Colindale, UK.
authors.forename: M
authors.initials: M
authors.lastname: Chattaway
authors.affiliation: Antimicrobial Resistance and Healthcare Associated Infections (AMRHAI) Reference Unit, Public Health England, Colindale, UK.
authors.forename: M
authors.initials: M
authors.lastname: Doumith
authors.affiliation: Centre for Infectious Disease Surveillance and Control, Healthcare Associated Infection and Antimicrobial Resistance Department, Public Health England, Colindale, UK.
authors.forename: R
authors.initials: R
authors.lastname: Hope
authors.affiliation: Antimicrobial Research Group, Centre for Immunology and Infectious Disease, Blizard Institute, Bart's and the London School of Medicine and Dentistry, Queen Mary, University of London, E1 2AT, London, UK.|Antimicrobial Resistance and Healthcare Associated Infections (AMRHAI) Reference Unit, Public Health England, Colindale, UK.
authors.forename: N
authors.initials: N
authors.lastname: Woodford
authors.affiliation: Antimicrobial Research Group, Centre for Immunology and Infectious Disease, Blizard Institute, Bart's and the London School of Medicine and Dentistry, Queen Mary, University of London, E1 2AT, London, UK.
authors.forename: D W
authors.initials: DW
authors.lastname: Wareham
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia / Q000453:epidemiology / Q000382:microbiology; D015373:Bacterial Typing Techniques; D002648:Child; D002675:Child, Preschool; D004927:Escherichia coli Infections / Q000453:epidemiology / Q000382:microbiology*; D000072282:Extraintestinal Pathogenic Escherichia coli / Q000145:classification* / Q000302:isolation & purification; D005260:Female; D005838:Genotype; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D065288:Serogroup; D006113:United Kingdom / Q000453:epidemiology; D014552:Urinary Tract Infections / Q000453:epidemiology / Q000382:microbiology; D055815:Young Adult