title: Impact of Visceral Obesity on Microvascular Invasion in Hepatocellular Carcinoma.
abstract: BACKGROUND
  Our objective was to determine whether visceral obesity is associated with increased microvascular invasion (MVI) in patients surgically treated for hepatocellular carcinoma (HCC).
  
  
  METHODS
  Data were collected retrospectively in a series of 79 patients treated by surgical resection for HCC, using CT-scan for evaluation of visceral obesity.
  
  
  RESULTS
  There was no significant association between visceral obesity and MVI (OR = 1.20 (0.38-3.75), p = 0.75). Independent predictive factors of MVI were moderate/poor differentiation, tumor size above 50 mm and underlying cirrhosis.
  
  
  CONCLUSIONS
  This study did not support the hypothesis that visceral obesity might promote MVI in patients with HCC.
authors.affiliation: a Department of Hepato-Gastroenterology , Reims University Hospital , Reims , France.
authors.forename: Nicolae
authors.initials: N
authors.lastname: Arsenii
authors.affiliation: b Department of General , Digestive and Endocrine Surgery, Reims University Hospital , Reims , France.
authors.forename: Tullio
authors.initials: T
authors.lastname: Piardi
authors.affiliation: c Department of Biopathology , Reims University Hospital , Reims , France.
authors.forename: Marie-Danièle
authors.initials: MD
authors.lastname: Diébold
authors.affiliation: d Department of Histopathology , University Hospitals of Strasbourg , Strasbourg , France.
authors.forename: Marie-Pierrette
authors.initials: MP
authors.lastname: Chenard
authors.affiliation: e Department of Research and Innovation , Reims University Hospital , Reims , France.
authors.forename: Moustapha
authors.initials: M
authors.lastname: Drame
authors.affiliation: a Department of Hepato-Gastroenterology , Reims University Hospital , Reims , France.
authors.forename: Louis
authors.initials: L
authors.lastname: De Mestier
authors.affiliation: f Department of Radiology , Reims University Hospital , Reims , France.
authors.forename: Christine
authors.initials: C
authors.lastname: Hoeffel
authors.affiliation: g Department of Digestive Surgery , University Hospitals of Strasbourg , Strasbourg , France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Pessaux
authors.affiliation: b Department of General , Digestive and Endocrine Surgery, Reims University Hospital , Reims , France.
authors.forename: Daniele
authors.initials: D
authors.lastname: Sommacale
authors.affiliation: a Department of Hepato-Gastroenterology , Reims University Hospital , Reims , France.
authors.forename: Gérard
authors.initials: G
authors.lastname: Thiéfin
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor; D001706:Biopsy; D001837:Body Weights and Measures; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000473:pathology* / Q000601:surgery; D015897:Comorbidity; D005260:Female; D005355:Fibrosis; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications* / Q000473:pathology* / Q000601:surgery; D008297:Male; D055806:Microvessels / Q000473:pathology*; D008875:Middle Aged; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D009389:Neovascularization, Pathologic; D056128:Obesity, Abdominal / Q000150:complications* / Q000000981:diagnostic imaging; D016017:Odds Ratio; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor
keywords: Angiogenesis; Invasion and Metastasis; Liver and Billary System Cancer; Visceral obesity