title: Effects of lifestyle intervention on weight and metabolic parameters in patients with impaired glucose tolerance related to beta-3 adrenergic receptor gene polymorphism Trp64Arg(C/T): Results from the Japan Diabetes Prevention Program.
abstract: The beta-3 adrenergic receptor (ADRB3), primarily expressed in adipose tissue, is involved in the regulation of energy metabolism. The present study hypothesized that ADRB3 (Trp64Arg, rs4994) polymorphisms modulate the effects of lifestyle intervention on weight and metabolic parameters in patients with impaired glucose tolerance. Data were analyzed from 112 patients with impaired glucose tolerance in the Japan Diabetes Prevention Program, a lifestyle intervention trial, randomized to either an intensive lifestyle intervention group or usual care group. Changes in weight and metabolic parameters were measured after the 6-month intervention. The ADRB3 polymorphisms were determined using the polymerase chain reaction restriction fragment length polymorphism method. Non-carriers showed a greater weight reduction compared with the carriers in both the lifestyle intervention group and usual care group, and a greater increase of high-density lipoprotein cholesterol levels than the carriers only in the lifestyle intervention group. ADRB3 polymorphisms could influence the effects of lifestyle interventions on weight and lipid parameters in impaired glucose tolerance patients.
authors.affiliation: Division of Preventive Medicine Clinical Research Institute National Hospital Organization Kyoto Medical Center Kyoto Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Sakane
authors.affiliation: Department of General Medicine/Family & Community Medicine Nagoya University Graduate School of Medicine Nagoya Japan.
authors.forename: Juichi
authors.initials: J
authors.lastname: Sato
authors.affiliation: Comprehensive Health Science Center Aichi Health Promotion Foundation Higashiura-cho Aichi Japan.
authors.forename: Kazuyo
authors.initials: K
authors.lastname: Tsushita
authors.affiliation: Diabetes Center Tenri Yorozu-sodansho Hospital Tenri Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Tsujii
authors.affiliation: Division of Preventive Medicine Clinical Research Institute National Hospital Organization Kyoto Medical Center Kyoto Japan; Division of Community and Family Medicine Jichi Medical University Tochigi Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Kotani
authors.affiliation: Division of Internal Medicine Hananoie Hospital Tochigi Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Tominaga
authors.affiliation: Department of Diabetes and Metabolism The Institute for Adult Diseases Asahi Life Foundation Tokyo Japan.
authors.forename: Shoji
authors.initials: S
authors.lastname: Kawazu
authors.affiliation: The Graduate Center of Human Science Aichi Mizuho College Nagoya Japan.
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Sato
authors.affiliation: Division of Endocrinology Clinical Research Institute National Hospital Organization Kyoto Medical Center Kyoto Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Usui
authors.affiliation: Graduate School of Public Policy The University of Tokyo Tokyo Japan.
authors.forename: Isao
authors.initials: I
authors.lastname: Kamae
authors.affiliation: Obesity and Diabetes Center Shimabara Hospital Kyoto Japan.
authors.forename: Toshihide
authors.initials: T
authors.lastname: Yoshida
authors.affiliation: Department of Medicine and Clinical Science Graduate School of Medical Sciences Kyusyu University Fukuoka Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kiyohara
authors.affiliation: Hirakata General Hospital for Developmental Disorders Hirakata Osaka Japan.
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Sato
authors.affiliation: Division of Preventive Medicine Clinical Research Institute National Hospital Organization Kyoto Medical Center Kyoto Japan.
authors.forename: Kokoro
authors.initials: K
authors.lastname: Tsuzaki
authors.affiliation: Division of Preventive Medicine Clinical Research Institute National Hospital Organization Kyoto Medical Center Kyoto Japan; Hyogo Health Service Association Hyogo Japan.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Takahashi
authors.affiliation: Division of Preventive Medicine Clinical Research Institute National Hospital Organization Kyoto Medical Center Kyoto Japan; Takeda Hospital Kyoto Japan.
authors.forename: Hideshi
authors.initials: H
authors.lastname: Kuzuya
mesh_terms: D000328:Adult; D001835:Body Weight; D003920:Diabetes Mellitus / Q000517:prevention & control*; D004038:Diet, Reducing; D004734:Energy Metabolism; D005081:Exercise Therapy; D005260:Female; D018149:Glucose Intolerance / Q000235:genetics* / Q000378:metabolism / Q000517:prevention & control*; D006801:Humans; D007564:Japan; D007899:Leisure Activities; D008019:Life Style; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D022702:Receptors, Adrenergic, beta-3 / Q000235:genetics*; D016896:Treatment Outcome
chemical_list: D022702:Receptors, Adrenergic, beta-3
keywords: Beta‐3 adrenergic receptor; Diabetes prevention; Impaired glucose tolerance