title: Anesthesia and cognitive disorders: a systematic review of the clinical evidence.
abstract: Preclinical and clinical evidence suggest an association between anesthesia and cognitive disorders ranging from postoperative chronic dysfunction to Alzheimer's disease. Recent clinical insights are summarized in this paper. Areas covered: This systematic review was conducted and written in accordance with the preferred reporting items for systematic reviews and meta-analyses statement and was registered in the International Prospective Register of Systematic Review database. A literature search of PubMed, EMBASE and SCOPUS was accomplished according to a written protocol that included: clinical trials on humans, articles in English, papers published between April 2010 and February 2016 and complete studies. Expert commentary: There is a growing interest in establishing the possible relationship between anesthesia and the onset and progression of cognitive disorders. Further studies are required to determine the methods of monitoring anesthesia in older adults with dementia undergoing surgical procedures.
authors.affiliation: a Department of Anesthesiology, Critical Care and Pain Medicine , 'Sapienza' University of Rome , Rome , Italy.
authors.forename: Federico
authors.initials: F
authors.lastname: Bilotta
authors.affiliation: a Department of Anesthesiology, Critical Care and Pain Medicine , 'Sapienza' University of Rome , Rome , Italy.
authors.forename: Ega
authors.initials: E
authors.lastname: Qeva
authors.affiliation: b Department of Anesthesiology, Intensive Care and Pain Medicine , Tel Aviv Medical Center , Tel Aviv , Israel.
authors.forename: Idit
authors.initials: I
authors.lastname: Matot
mesh_terms: D000544:Alzheimer Disease / Q000209:etiology; D000758:Anesthesia / Q000009:adverse effects; D003071:Cognition; D003072:Cognition Disorders / Q000209:etiology; D006801:Humans; D011446:Prospective Studies
keywords: Anesthesia and Alzheimer; anesthetics and AD biomarkers; bispectral (BIS) - guided anesthesia and postoperative cognitive dysfunction (POCD); cerebrospinal fluid and Alzheimer’s disease (AD) biomarkers; postoperative cognitive dysfunction; β-amyloid protein to tau ratio