title: Impaired executive functions in experimental model of temporal lobe epilepsy.
abstract: OBJECTIVE
  The present study aimed to investigate cognitive and behavioural changes consistent with attention deficit hyperactivity disorder (ADHD -like behavior in male Wistar rats with temporal lobe epilepsy (TLE).
  
  
  METHODS
  Male Wistar rats at 25 day of age were submitted to animal model of TLE by pilocarpine injection (350 mg/kg, ip) and a control group received saline 0.9%. The animals were continuously video monitored up to the end of experiments. The behavioural tests (open field, elevated plus maze and operant conditioning box) started from 60 days postnatal.
  
  
  RESULTS
  Animals with TLE exhibited elevated locomotor activity, reduced level of anxiety-related behavior, impulsivity and impaired visuospatial working memory.
  
  
  CONCLUSIONS
  Taken as a whole, we concluded that animals with TLE exhibited some cognitive and behavioural changes consistent with ADHD-like behavior.
authors.affiliation: Universidade Presbiteriana Mackenzie, Universidade Presbiteriana Mackenzie, Laboratório de Neurobiologia, São Paulo SP , Brasil, Universidade Presbiteriana Mackenzie, Laboratório de Neurobiologia, Programa de Pós-Graduação em Distúrbios do Desenvolvimento, São Paulo SP, Brasil;|Universidade Federal de São Paulo, Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Neurologia e Neurocirurgia, São Paulo SP , Brasil, Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Neurologia e Neurocirurgia, São Paulo SP, Brasil.
authors.forename: Fabiane Ochai
authors.initials: FO
authors.lastname: Ramos
authors.affiliation: Universidade Presbiteriana Mackenzie, Universidade Presbiteriana Mackenzie, Laboratório de Neurobiologia, São Paulo SP , Brasil, Universidade Presbiteriana Mackenzie, Laboratório de Neurobiologia, Programa de Pós-Graduação em Distúrbios do Desenvolvimento, São Paulo SP, Brasil;
authors.forename: Luiz Renato Rodrigues
authors.initials: LR
authors.lastname: Carreiro
authors.affiliation: Universidade Federal de São Paulo, Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Neurologia e Neurocirurgia, São Paulo SP , Brasil, Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Neurologia e Neurocirurgia, São Paulo SP, Brasil.
authors.forename: Fulvio Alexandre
authors.initials: FA
authors.lastname: Scorza
authors.affiliation: Universidade Presbiteriana Mackenzie, Universidade Presbiteriana Mackenzie, Laboratório de Neurobiologia, São Paulo SP , Brasil, Universidade Presbiteriana Mackenzie, Laboratório de Neurobiologia, Programa de Pós-Graduação em Distúrbios do Desenvolvimento, São Paulo SP, Brasil;
authors.forename: Roberta Monterazzo
authors.initials: RM
authors.lastname: Cysneiros
mesh_terms: D000818:Animals; D001289:Attention Deficit Disorder with Hyperactivity / Q000209:etiology* / Q000503:physiopathology; D004195:Disease Models, Animal; D004833:Epilepsy, Temporal Lobe / Q000150:complications* / Q000503:physiopathology; D056344:Executive Function / Q000502:physiology*; D005106:Exploratory Behavior / Q000502:physiology*; D007839:Functional Laterality / Q000502:physiology; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000502:physiology