title: Endometrial cancer risk factors among Lynch syndrome women: a retrospective cohort study.
abstract: Lynch syndrome (LS) is associated with a significant lifetime risk of endometrial cancer (EC). There are limited data on factors modifying the EC risk in LS patients.
  
  
  
  The study cohort included 136 LS mutation-positive women. Exposure data were collected by postal questionnaires. Cox regression model was used to estimate the associations between lifestyle, hormonal, reproductive and medical factors and the risk of EC.
  
  
  
  Increased EC risk was associated with type II diabetes and hypercholesterolaemia in univariable (HR 3.21, (95% CI 1.34-7.78), P=0.009 and HR 2.08, (95% CI 1.11-3.90), P=0.02; respectively) and with diabetes and duration of hormone replacement therapy (HRT) in multivariable analysis (HR 4.18 (95% CI 1.52-11.52), P=0.006 and HR 1.07 (95% CI 1.02-1.13), P=0.010; respectively).
  
  
  
  Prevention of diabetes and avoiding long-duration HRT are potential targets for reduction of EC risk in women with LS.
authors.affiliation: Department of Obstetrics and Gynecology, Tampere University Hospital, Tampere, Finland.|Laboratory of Cancer Biology, BioMediTech, University of Tampere, Tampere, Finland.
authors.forename: Synnöve
authors.initials: S
authors.lastname: Staff
authors.affiliation: Department of Obstetrics and Gynecology, Tampere University Hospital, Tampere, Finland.
authors.forename: Mari
authors.initials: M
authors.lastname: Aaltonen
authors.affiliation: School of Health Sciences, University of Tampere, Tampere, Finland.
authors.forename: Heini
authors.initials: H
authors.lastname: Huhtala
authors.affiliation: Department of Education and Research, Jyväskylä Central Hospital, Jyväskylä, Finland.
authors.forename: Kirsi
authors.initials: K
authors.lastname: Pylvänäinen
authors.affiliation: Department of Surgery, Jyväskylä Central Hospital and University of Eastern Finland, Jyväskylä, Finland.
authors.forename: Jukka-Pekka
authors.initials: JP
authors.lastname: Mecklin
authors.affiliation: Department of Obstetrics and Gynecology, Tampere University Hospital, Tampere, Finland.|School of Medicine, University of Tampere, Tampere, Finland.
authors.forename: Johanna
authors.initials: J
authors.lastname: Mäenpää
mesh_terms: D000328:Adult; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000150:complications / Q000453:epidemiology*; D016889:Endometrial Neoplasms / Q000150:complications / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors