title: Evaluation of survivin expression in prostate specimens of patients with prostate adenocarcinoma and benign prostate hyperplasia underwent transurethral resection of the prostate or prostatectomy.
abstract: BACKGROUND
  Survivin is a newly found member of the inhibitors of apoptosis proteins, which plays a certain role in cancer. Survivin has a distinctly different expression in cancers, including prostate cancer. We are searching for the relationship between survivin levels in normal prostate tissue, benign prostate hyperplasia (BPH), and prostate adenocarcinoma in this study.
  
  
  RESULTS
  The study surveyed 282 prostate samples, 94 normal, 94 BPH, and 94 prostate adenocarcinoma samples. Survivin expression was absent in normal prostate tissues. In the BPH group, the survivin expression level was higher than that of the normal group. In the adenocarcinoma group, the survivin expression level was higher than that of the BPH group. There was a significant association between survivin expression level and the adenocarcinoma stage.
  
  
  CONCLUSIONS
  Although there is no expression of survivin in normal prostate tissue, its expression is slightly positive in BPH. High survivin expression is related to a higher Gleason score in the adenocarcinoma of the prostate.
authors.affiliation: Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran.
authors.forename: Mansooreh
authors.initials: M
authors.lastname: Eslami
authors.affiliation: Anatomical Science Research Center, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran.
authors.forename: Tahere
authors.initials: T
authors.lastname: Khamechian
authors.affiliation: Gametogenese Research Center, Kashan University of Medical Sciences, 5th Km Qotbe Ravandi Blv, Kashan, Islamic Republic of Iran.
authors.forename: Tahere
authors.initials: T
authors.lastname: Mazoochi
authors.affiliation: Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran.
authors.forename: Hasan
authors.initials: H
authors.lastname: Ehteram
authors.affiliation: Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran.
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Sehat
authors.affiliation: Student Research Committee, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran.
authors.forename: Javad
authors.initials: J
authors.lastname: Alizargar