title: Nucleophilic Difluoromethylation Using (Bromodifluoromethyl)trimethylsilane.
abstract: A combination of (bromodifluoromethyl)trimethylsilane (Me3SiCF2Br), triphenylphosphine, and DMPU serves as a source of difluorinated phosphorus ylide Ph3P═CF2 under mild conditions. The system was used to effect nucleophilic difluoromethylation of ketones and nitro alkenes. The reaction efficiency is believed to be associated with Lewis acidic activation of the substrates by a silylium species formed upon generation of the phosphorus ylide.
authors.affiliation: N. D. Zelinsky Institute of Organic Chemistry, 119991 Moscow, Leninsky prosp. 47, Russian Federation.|Higher Chemical College, Russian Academy of Sciences , 125047 Moscow, Miusskaya sq. 9, Russian Federation.
authors.forename: Alexey L
authors.initials: AL
authors.lastname: Trifonov
authors.affiliation: N. D. Zelinsky Institute of Organic Chemistry, 119991 Moscow, Leninsky prosp. 47, Russian Federation.
authors.forename: Artem A
authors.initials: AA
authors.lastname: Zemtsov
authors.affiliation: N. D. Zelinsky Institute of Organic Chemistry, 119991 Moscow, Leninsky prosp. 47, Russian Federation.
authors.forename: Vitalij V
authors.initials: VV
authors.lastname: Levin
authors.affiliation: N. D. Zelinsky Institute of Organic Chemistry, 119991 Moscow, Leninsky prosp. 47, Russian Federation.
authors.forename: Marina I
authors.initials: MI
authors.lastname: Struchkova
authors.affiliation: N. D. Zelinsky Institute of Organic Chemistry, 119991 Moscow, Leninsky prosp. 47, Russian Federation.
authors.forename: Alexander D
authors.initials: AD
authors.lastname: Dilman