title: Microbial Profile and Antimicrobial Susceptibility of Bacteria Found in Inflammatory Hidradenitis Suppurativa Lesions.
abstract: BACKGROUND
  The role of bacterial colonization in hidradenitis suppurativa (HS) lesions is poorly understood. To date, data on the related microbial profile and especially on bacterial resistance rates are scarce.
  
  
  METHODS
  The results of bacterial cultures and susceptibility patterns of the isolated microorganisms obtained from deep portions of HS lesions from patients who underwent surgery at our HS Centre between 2010 and 2015 were retrospectively evaluated.
  
  
  RESULTS
  Analyses of 113 bacterial samples from 113 HS patients revealed bacterial growth in 95 samples (84.1%). Polymicrobial growth was found in 51 samples (45.1%). Coagulase-negative staphylococci and Staphylococcus aureus were the most commonly isolated bacteria, followed by Proteus mirabilis and Escherichia coli. Data on susceptibility testing were available for 68 samples, which yielded 129 isolates. The isolated strains were primarily resistant to penicillin G, followed by erythromycin, clindamycin and ampicillin. The highest effectiveness against isolates was observed for fosfomycin, imipenem, fluoroquinolones (moxifloxacin, ciprofloxacin, levofloxacin), and cotrimoxazole.
  
  
  CONCLUSIONS
  Our findings on bacterial species and their topographical distribution revealed that the microbial flora in HS lesions reflects commensal flora of the skin. Due to the susceptibility rate and immunomodulatory and anti-inflammatory properties, cotrimoxazole may represent an alternative antibiotic agent and should be considered for therapy in HS patients.
authors.affiliation: Department of Dermatology, Venereology and Allergology, Ruhr University Bochum, Bochum, Germany.
authors.forename: Schapoor
authors.initials: S
authors.lastname: Hessam
authors.forename: Michael
authors.initials: M
authors.lastname: Sand
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Georgas
authors.forename: Agnes
authors.initials: A
authors.lastname: Anders
authors.forename: Falk G
authors.initials: FG
authors.lastname: Bechara
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D024881:Drug Resistance, Bacterial / Q000187:drug effects* / Q000502:physiology; D004926:Escherichia coli / Q000187:drug effects / Q000302:isolation & purification; D005260:Female; D017497:Hidradenitis Suppurativa / Q000175:diagnosis* / Q000188:drug therapy*; D006801:Humans; D007249:Inflammation / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D011513:Proteus mirabilis / Q000187:drug effects / Q000302:isolation & purification; D012189:Retrospective Studies; D013211:Staphylococcus aureus / Q000187:drug effects / Q000302:isolation & purification
chemical_list: D000890:Anti-Infective Agents