title: Proteome data of whole saliva which are associated with development of oral mucositis in head and neck cancer patients undergoing radiotherapy.
abstract: Saliva as major human body fluid may act as an indicator of oral disease status. Oral mucositis is a common and often treatment-limiting side effect of radiotherapy for head and neck cancer patients. In this dataset, we provide the complete proteome dataset (raw and search files) of the patients at baseline of radiotherapy treatment in patients undergoing radiotherapy analyzed by nano liquid chromatography coupled to mass spectrometry (LC-MS/MS). In the data set, 5323 tryptic peptides were identified which can be assigned to 487 distinct proteins (≥2 peptides). The MS data have been deposited to the ProteomeXchange ("ProteomeXchange provides globally coordinated proteomics data submission and dissemination" [1]) via the PRIDE partner repository with the dataset identifier PRIDE: PXD003230. The data are associated with the previously published work, "Differences in the whole saliva baseline proteome profile associated with development of oral mucositis in head and neck cancer patients undergoing radiotherapy" [2].
authors.affiliation: Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Germany.
authors.forename: Nico
authors.initials: N
authors.lastname: Jehmlich
authors.affiliation: Department of Radiation Oncology, University Medical Center Freiburg, Germany.
authors.forename: Petra
authors.initials: P
authors.lastname: Stegmaier
authors.affiliation: Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Germany.
authors.forename: Claas
authors.initials: C
authors.lastname: Golatowski
authors.affiliation: Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Germany.
authors.forename: Manuela Gesell
authors.initials: MG
authors.lastname: Salazar
authors.affiliation: Department of Radiation Oncology, University Medical Center Freiburg, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Rischke
authors.affiliation: Department of Radiation Oncology, University Medical Center Freiburg, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Henke
authors.affiliation: Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Germany.
authors.forename: Uwe
authors.initials: U
authors.lastname: Völker
keywords: Head and neck cancer; Oral mucositis; Prospective study; Radiochemotherapy; Radiotherapy; Whole saliva