title: The relationship between perifoveal achromatic, L- and M-cone acuity and retinal structure as assessed with multimodal high resolution imaging.
abstract: The relationships between perifoveal measures of achromatic-, L- and M-cone acuity and retinal structure were investigated in healthy young males. Thirty-two males, aged 20-39years, with normal foveal logMAR letter acuity and no observed ocular abnormalities participated in the study. Achromatic and isolated L- and M-cone spatial acuity was measured in the dominant eye with a Sloan E letter of 90% achromatic decrement contrast or 23% increment cone contrast, respectively. Separately, the central part of the same eye was imaged with high-resolution spectral-domain optical coherence tomography (SD-OCT) and adaptive optics ophthalmoscopy (AOO). Thickness measures and cone density in the fovea and parafoveal region were not correlated with perifoveal structural measures. A significant correlation was observed between thicker retinal pigment epithelium (RPE) complex, higher cone density and better L-cone logMAR at 5deg eccentricity, but not for achromatic or M-cone logMAR. The results imply that single letter perifoveal L-cone acuity, rather than achromatic acuity, may provide a useful measure for assessing the structure-function relationship and detecting early changes in the perifoveal cone mosaic.
authors.affiliation: National Centre for Optics, Vision and Eye Care, Department of Optometry and Visual Science, Faculty of Health Sciences, University College of Southeast Norway, Kongsberg, Norway. Electronic address: rigmor.baraas@hbv.no.
authors.forename: Rigmor C
authors.initials: RC
authors.lastname: Baraas
authors.affiliation: National Centre for Optics, Vision and Eye Care, Department of Optometry and Visual Science, Faculty of Health Sciences, University College of Southeast Norway, Kongsberg, Norway.
authors.forename: Jon V B
authors.initials: JV
authors.lastname: Gjelle
authors.affiliation: National Centre for Optics, Vision and Eye Care, Department of Optometry and Visual Science, Faculty of Health Sciences, University College of Southeast Norway, Kongsberg, Norway.
authors.forename: Elisabeth Bratlie
authors.initials: EB
authors.lastname: Finstad
authors.affiliation: National Centre for Optics, Vision and Eye Care, Department of Optometry and Visual Science, Faculty of Health Sciences, University College of Southeast Norway, Kongsberg, Norway.
authors.forename: Siri Bjørnetun
authors.initials: SB
authors.lastname: Jacobsen
authors.affiliation: National Centre for Optics, Vision and Eye Care, Department of Optometry and Visual Science, Faculty of Health Sciences, University College of Southeast Norway, Kongsberg, Norway.
authors.forename: Stuart J
authors.initials: SJ
authors.lastname: Gilson
mesh_terms: D000328:Adult; D002452:Cell Count; D003119:Color Perception Tests; D055253:Color Vision / Q000502:physiology*; D055358:Cone Opsins / Q000502:physiology*; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D064847:Multimodal Imaging; D009887:Ophthalmoscopy; D012160:Retina / Q000033:anatomy & histology*; D017949:Retinal Cone Photoreceptor Cells / Q000502:physiology*; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology*; D055815:Young Adult
chemical_list: D055358:Cone Opsins
keywords: Adaptive optics ophthalmoscopy; Cone density; L:M ratio; Optical coherence tomography; Outer nuclear layer thickness; Perifoveal achromatic and chromatic spatial acuity; RPE complex thickness