title: Pneumococcal pneumonia vaccine breakthroughs and failures after 13-valent pneumococcal conjugated vaccine.
abstract: The rate of invasive pneumococcal disease has markedly declined after the introduction of pneumococcal conjugated vaccines. In spite of the high effectiveness of this vaccine, there are some reports of vaccine failure and vaccine breakthroughs. Data on children with pneumococcal pneumonia in a European tertiary Hospital, from 2012 to 2014, were retrospectively collected before the implementation of pneumococcal conjugated vaccines in our country. We found four cases of pneumococcal serotype 3 vaccine failure and three cases of vaccine breakthroughs (two with serotype 3 and one with serotype 19A). All of these children were previously healthy.
authors.affiliation: Department of Paediatrics, São João Hospital, Porto, Portugal anafpsalmeida@gmail.com.
authors.forename: Ana Filipe
authors.initials: AF
authors.lastname: Almeida
authors.affiliation: Department of Clinical Microbiology Laboratory, São João Hospital, Porto, Portugal.
authors.forename: Joana
authors.initials: J
authors.lastname: Sobrinho-Simões
authors.affiliation: Department of Paediatric Pulmonology, São João Hospital, Porto, Portugal.
authors.forename: Catarina
authors.initials: C
authors.lastname: Ferraz
authors.affiliation: Department of Paediatric Pulmonology, São João Hospital, Porto, Portugal.
authors.forename: Teresa
authors.initials: T
authors.lastname: Nunes
authors.affiliation: Department of Paediatric Pulmonology, São João Hospital, Porto, Portugal.
authors.forename: Luisa
authors.initials: L
authors.lastname: Vaz
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D022242:Pneumococcal Vaccines / Q000627:therapeutic use*; D011018:Pneumonia, Pneumococcal / Q000453:epidemiology / Q000517:prevention & control*; D011174:Portugal / Q000453:epidemiology; D015995:Prevalence; D012189:Retrospective Studies; D013296:Streptococcus pneumoniae / Q000187:drug effects*; D062606:Tertiary Care Centers / Q000706:statistics & numerical data*; D018074:Vaccines, Conjugate / Q000627:therapeutic use*
chemical_list: C538862:13-valent pneumococcal vaccine; D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate