title: The potential biomarkers of drug addiction: proteomic and metabolomics challenges.
abstract: Drug addiction places a significant burden on society and individuals. Proteomics and metabolomics approaches pave the road for searching potential biomarkers to assist the diagnosis and treatment. This review summarized putative drug addiction-related biomarkers in proteomics and metabolomics studies and discussed challenges and prospects in future studies. Alterations of several hundred proteins and metabolites were reported when exposure to abused drug, which enriched in energy metabolism, oxidative stress response, protein modification and degradation, synaptic function and neurotrasmission, etc. Hsp70, peroxiredoxin-6 and α- and β-synuclein, as well as n-methylserotonin and purine metabolites, were promising as potential biomarker for drug addiction.
authors.affiliation: a State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Key Laboratory of Neuropsychopharmacology , Beijing Institute of Pharmacology and Toxicology , Beijing , China.
authors.forename: Lv
authors.initials: L
authors.lastname: Wang
authors.affiliation: a State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Key Laboratory of Neuropsychopharmacology , Beijing Institute of Pharmacology and Toxicology , Beijing , China.
authors.forename: Ning
authors.initials: N
authors.lastname: Wu
authors.affiliation: a State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Key Laboratory of Neuropsychopharmacology , Beijing Institute of Pharmacology and Toxicology , Beijing , China.
authors.forename: Tai-Yun
authors.initials: TY
authors.lastname: Zhao
authors.affiliation: a State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Key Laboratory of Neuropsychopharmacology , Beijing Institute of Pharmacology and Toxicology , Beijing , China.
authors.forename: Jin
authors.initials: J
authors.lastname: Li
keywords: Biomarkers; drug addiction; metabolomics; proteomics