title: The PaPsr1 and PaWhi2 genes are members of the regulatory network that connect stationary phase to mycelium differentiation and reproduction in Podospora anserina.
abstract: In filamentous fungi, entrance into stationary phase is complex as it is accompanied by several differentiation and developmental processes, including the synthesis of pigments, aerial hyphae, anastomoses and sporophores. The regulatory networks that control these processes are still incompletely known. The analysis of the "Impaired in the development of Crippled Growth (IDC)" mutants of the model filamentous ascomycete Podospora anserina has already yielded important information regarding the pathway regulating entrance into stationary phase. Here, the genes affected in two additional IDC mutants are identified as orthologues of the Saccharomyces cerevisiae WHI2 and PSR1 genes, known to regulate stationary phase in this yeast, arguing for a conserved role of these proteins throughout the evolution of ascomycetes.
authors.affiliation: Univ Paris Diderot, Sorbonne Paris Cité, Laboratoire Interdisciplinaire des Energies de Demain, 75205 Paris CEDEX 13, France; Univ Paris Sud 11, Institut de Génétique et Microbiologie, 91405 Orsay cedex, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Timpano
authors.affiliation: Univ Paris Diderot, Sorbonne Paris Cité, Laboratoire Interdisciplinaire des Energies de Demain, 75205 Paris CEDEX 13, France.
authors.forename: Laetitia
authors.initials: L
authors.lastname: Chan Ho Tong
authors.affiliation: Univ Paris Diderot, Sorbonne Paris Cité, Laboratoire Interdisciplinaire des Energies de Demain, 75205 Paris CEDEX 13, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Gautier
authors.affiliation: Univ Paris Diderot, Sorbonne Paris Cité, Laboratoire Interdisciplinaire des Energies de Demain, 75205 Paris CEDEX 13, France.
authors.forename: Hervé
authors.initials: H
authors.lastname: Lalucque
authors.affiliation: Univ Paris Diderot, Sorbonne Paris Cité, Laboratoire Interdisciplinaire des Energies de Demain, 75205 Paris CEDEX 13, France. Electronic address: philippe.silar@univ-paris-diderot.fr.
authors.forename: Philippe
authors.initials: P
authors.lastname: Silar
mesh_terms: D005656:Fungal Proteins / Q000235:genetics; D015966:Gene Expression Regulation, Fungal; D053263:Gene Regulatory Networks; D005816:Genetic Complementation Test; D009154:Mutation; D025282:Mycelium / Q000235:genetics* / Q000254:growth & development; D010766:Phosphorylation; D048468:Podospora / Q000235:genetics* / Q000254:growth & development
chemical_list: D005656:Fungal Proteins
keywords: Fruiting body; MAP kinase; Nutrient sensing; Podospora anserina; Stationary phase