title: FLNA is a predictor of chemoresistance and poor survival in cervical cancer.
abstract: OBJECTIVE
  To investigate the expression of FLNA and its potential prognostic significance in cervical cancer.
  
  
  METHODS
  Real-time PCR was performed to evaluate the expression levels of FLNA in 44 pairs of cervical cancer and matched normal adjacent tissues. Kaplan-Meier analysis and Cox proportional hazards model were used to examine the correlation between FLNA expression levels and overall survival in cervical cancer patients.
  
  
  CONCLUSIONS
  FLNA was significantly upregulated in cervical cancer tissues. FLNA expression level was associated with lymph node metastasis, parametrial invasion and response to neoadjuvant chemotherapy and predicted poor survival in cervical cancer patients. FLNA may serve as a predictor of chemosensitivity and a prognostic biomarker of survival in cervical cancer.
authors.affiliation: Department of Obstetrics & Gynecology, Yanbian University Hospital, 1327 Juzi-Road, Yanji 133000, Jilin Province, China.
authors.forename: Yan-Ze
authors.initials: YZ
authors.lastname: Jin
authors.affiliation: Department of Obstetrics & Gynecology, Yanbian University Hospital, 1327 Juzi-Road, Yanji 133000, Jilin Province, China.
authors.forename: Chang-Zhu
authors.initials: CZ
authors.lastname: Pei
authors.affiliation: Department of Obstetrics & Gynecology, Yanbian University Hospital, 1327 Juzi-Road, Yanji 133000, Jilin Province, China.
authors.forename: Lan-Ying
authors.initials: LY
authors.lastname: Wen
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000378:metabolism; D019008:Drug Resistance, Neoplasm; D005260:Female; D064448:Filamins / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D011379:Prognosis; D016016:Proportional Hazards Models; D060888:Real-Time Polymerase Chain Reaction; D015854:Up-Regulation; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000473:pathology*
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; C578663:FLNA protein, human; D064448:Filamins
keywords: FLNA; cervical cancer; prognosis