title: O-GlcNAcylation in Cancer Biology: Linking Metabolism and Signaling.
abstract: The hexosamine biosynthetic pathway (HBP) is highly dependent on multiple metabolic nutrients including glucose, glutamine, and acetyl-CoA. Increased flux through HBP leads to elevated post-translational addition of β-D-N-acetylglucosamine sugars to nuclear and cytoplasmic proteins. Increased total O-GlcNAcylation is emerging as a general characteristic of cancer cells, and recent studies suggest that O-GlcNAcylation is a central communicator of nutritional status to control key signaling and metabolic pathways that regulate multiple cancer cell phenotypes. This review summarizes our current understanding of changes of O-GlcNAc cycling enzymes in cancer, the role of O-GlcNAcylation in tumorigenesis, and the current challenges in targeting this pathway therapeutically.
authors.affiliation: Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102, USA.
authors.forename: Christina M
authors.initials: CM
authors.lastname: Ferrer
authors.affiliation: Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102, USA.
authors.forename: Valerie L
authors.initials: VL
authors.lastname: Sodi
authors.affiliation: Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102, USA. Electronic address: Mauricio.Reginato@drexelmed.edu.
authors.forename: Mauricio J
authors.initials: MJ
authors.lastname: Reginato
mesh_terms: D000818:Animals; D053898:Biosynthetic Pathways / Q000502:physiology*; D063646:Carcinogenesis / Q000473:pathology*; D006031:Glycosylation; D006801:Humans; D053858:Metabolic Networks and Pathways / Q000502:physiology*; D009369:Neoplasms / Q000473:pathology*; D015398:Signal Transduction / Q000502:physiology
keywords: O-GlcNAcylation; OGT; cancer; glycosylation; signaling