title: Intracellular Growth of Bacterial Pathogens: The Role of Secreted Effector Proteins in the Control of Phagocytosed Microorganisms.
abstract: The ability of intracellular pathogens to subvert the host response, to facilitate invasion and subsequent infection, is the hallmark of microbial pathogenesis. Bacterial pathogens produce and secrete a variety of effector proteins, which are the primary means by which they exert control over the host cell. Secreted effectors work independently, yet in concert with each other, to facilitate microbial invasion, replication, and intracellular survival in host cells. In this review we focus on defined host cell processes targeted by bacterial pathogens. These include phagosome maturation and its subprocesses: phagosome-endosome and phagosome-lysosome fusion events, as well as phagosomal acidification, cytoskeleton remodeling, and lysis of the phagosomal membrane. We further describe the mode of action for selected effectors from six pathogens: the Gram-negative Legionella, Salmonella, Shigella, and Yersinia, the Gram-positive Listeria, and the acid-fast actinomycete Mycobacterium.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, BC V6H 3Z6.
authors.forename: Valérie
authors.initials: V
authors.lastname: Poirier
authors.affiliation: Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, BC V6H 3Z6.
authors.forename: Yossef
authors.initials: Y
authors.lastname: Av-Gay
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D006090:Gram-Negative Bacteria / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism; D016905:Gram-Negative Bacterial Infections / Q000382:microbiology* / Q000503:physiopathology; D006094:Gram-Positive Bacteria / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology* / Q000503:physiopathology; D006801:Humans; D010587:Phagocytosis
chemical_list: D001426:Bacterial Proteins