title: Gliosarcoma in the Cerebellopontine Angle with Rapid Tumor Growth and Intratumoral Hemorrhage.
abstract: BACKGROUND
  Gliosarcoma is a relatively rare and bimorphous brain tumor, predominantly located in the brain lobe. Here, we report a rare case of gliosarcoma presenting radiologically in the cerebellopontine angle (CPA) region.
  
  
  METHODS
  The patient was a 71-year-old woman with progressive tinnitus. A series of image examinations showed a rapidly growing CPA tumor, which enlarged from nonexistent to 4 cm in diameter with extension to the internal auditory canal in a short period of 6 months. The patient was operated on in emergency because of intratumoral hemorrhage and rapidly deteriorating neurologic symptoms. Under the diagnosis of gliosarcoma confirmed by pathologic examination, chemotherapy and radiotherapy were conducted after partial resection. The patient recovered uneventfully and the residual tumor disappeared nearly completely on the image taken 6 months later.
  
  
  CONCLUSIONS
  Although rare, gliosarcoma should be considered in the differential diagnosis of CPA tumors, especially if it is associated with rapid tumor growth or intratumoral hemorrhage.
authors.affiliation: Stroke and Brain Center, Aizawa Hospital, Honjo 2-5-1, Matsumoto, Japan; Department of Neurosurgery, Peking University First Hospital, Xicheng District, Beijing, China. Electronic address: duanhongzhou@126.com.
authors.forename: Hongzhou
authors.initials: H
authors.lastname: Duan
authors.affiliation: Stroke and Brain Center, Aizawa Hospital, Honjo 2-5-1, Matsumoto, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kitazawa
authors.affiliation: Stroke and Brain Center, Aizawa Hospital, Honjo 2-5-1, Matsumoto, Japan.
authors.forename: Takehiro
authors.initials: T
authors.lastname: Yako
authors.affiliation: Stroke and Brain Center, Aizawa Hospital, Honjo 2-5-1, Matsumoto, Japan.
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Ichinose
authors.affiliation: Stroke and Brain Center, Aizawa Hospital, Honjo 2-5-1, Matsumoto, Japan.
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Kobayashi
authors.affiliation: Department of Anatomic Pathology, Aizawa Hospital, Honjo 2-5-1, Matsumoto, Japan.
authors.forename: Motohiro
authors.initials: M
authors.lastname: Sudo
mesh_terms: D000368:Aged; D020201:Brain Hemorrhage, Traumatic / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery; D003399:Craniotomy; D005260:Female; D005500:Follow-Up Studies; D018316:Gliosarcoma / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery*; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D009464:Neuroma, Acoustic / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery*; D019635:Neurosurgical Procedures; D014057:Tomography, X-Ray Computed; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D019394:Ki-67 Antigen; D016159:Tumor Suppressor Protein p53
keywords: Cerebellopontine angle tumor; Gliosarcoma