title: Mechano-growth factor E peptide promotes healing of rat injured tendon.
abstract: OBJECTIVE
  To determine the possible beneficial effects of a synthetic mechano-growth factor E peptide (MGF-C25E) on the healing of rat Achilles tendon.
  
  
  RESULTS
  A significantly increased Achilles functional index was found in the MGF-C25E-treated tendons relative to the saline-treated tendons. Macroscopic observation showed that the repair of MGF-C25E-treated (1000 ng/ml) tendons was superior to that of the saline-treated tendons. The mean value of the stiffness of the repaired tendons was significantly increased in the MGF-C25E-treated (1000 ng/ml) tendons relative to the saline-treated tendons. Moreover, histological analysis provided evidence of tissue remodeling and cell alignment.
  
  
  CONCLUSIONS
  MGF-C25E plays an important role in promoting healing of injured rat tendon and could be used as a potential therapeutic factor for tendon repair.
authors.affiliation: Key Laboratory of Biorheological Science and Technology, College of Bioengineering, Ministry of Education, Chongqing University, Chongqing, 400044, China.|Post-doctoral Mobile Stations of Biology, Chongqing University, Chongqing, 400044, China.
authors.forename: Bingyu
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Biorheological Science and Technology, College of Bioengineering, Ministry of Education, Chongqing University, Chongqing, 400044, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Luo
authors.affiliation: Key Laboratory of Biorheological Science and Technology, College of Bioengineering, Ministry of Education, Chongqing University, Chongqing, 400044, China.
authors.forename: Dongdong
authors.initials: D
authors.lastname: Kuang
authors.affiliation: Department of Mechanical Science and Engineering, Nagoya University, Nagoya, 464-8603, Japan.
authors.forename: Yang
authors.initials: Y
authors.lastname: Ju
authors.affiliation: Key Laboratory of Biorheological Science and Technology, College of Bioengineering, Ministry of Education, Chongqing University, Chongqing, 400044, China. song@cqu.edu.cn.
authors.forename: Guanbin
authors.initials: G
authors.lastname: Song
mesh_terms: D000125:Achilles Tendon / Q000187:drug effects / Q000293:injuries* / Q000503:physiopathology; D000818:Animals; D004195:Disease Models, Animal; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology; D008297:Male; D010446:Peptide Fragments / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013708:Tendon Injuries / Q000188:drug therapy*; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects
chemical_list: D010446:Peptide Fragments; C519382:mechano-growth factor, rat; D007334:Insulin-Like Growth Factor I
keywords: E-Peptide; Injury; Mechano-growth factor; Repair; Tendon healing; Tissue repair