title: Usefulness of the LDL-C/apoB ratio in the overall evaluation of atherogenicity of lipid profile.
abstract: BACKGROUND
  The ratio of low-density lipoprotein cholesterol to apolipoprotein-B (LDL-C/apoB) conventionally represents an alternative index of LDL particle size.
  
  
  OBJECTIVE
  This study was undertaken to determine the importance of LDL-C/apoB ratio in the overall evaluation of atherogenicity of lipid profile.
  
  
  METHODS
  The plasma levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), apolipoprotein (apo) A-I, apoB and apoE were measured in 186 apparently healthy men using enzymatic and immunoturbidimetric methods.
  
  
  RESULTS
  The subjects with low values of the LDL-C/apoB ratio, indicating a predominance of small dense LDL (sd-LDL) particles in plasma, were characterized by higher TG levels and lower apoE levels.
  
  
  CONCLUSIONS
  Low levels of apoE are most likely a cause of reduced clearance of TG-rich lipoproteins, which promotes the formation of sd-LDL. Determination of the LDL-C/apoB ratio can be used for monitoring qualitative changes in lipid profile, in addition to traditional lipid variables indicating quantitative changes.
authors.affiliation: a Institute of Physiology, Komi Science Center, Ural Branch of Russian Academy of Sciences , Syktyvkar , Russia.
authors.forename: Anastasiya M
authors.initials: AM
authors.lastname: Kaneva
authors.affiliation: a Institute of Physiology, Komi Science Center, Ural Branch of Russian Academy of Sciences , Syktyvkar , Russia.
authors.forename: Natalya N
authors.initials: NN
authors.lastname: Potolitsyna
authors.affiliation: a Institute of Physiology, Komi Science Center, Ural Branch of Russian Academy of Sciences , Syktyvkar , Russia.
authors.forename: Evgeny R
authors.initials: ER
authors.lastname: Bojko
mesh_terms: D000328:Adult; D000465:Algorithms; D053299:Apolipoprotein B-100 / Q000097:blood*; D001057:Apolipoproteins E / Q000097:blood; D050197:Atherosclerosis / Q000453:epidemiology / Q000209:etiology*; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D008078:Cholesterol, LDL / Q000097:blood*; D050171:Dyslipidemias / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D042241:Early Diagnosis; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000503:physiopathology; D050177:Overweight / Q000097:blood* / Q000503:physiopathology; D012307:Risk Factors; D012426:Russia / Q000453:epidemiology; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: C569471:APOB protein, human; C000612345:ApoE protein, human; D053299:Apolipoprotein B-100; D001057:Apolipoproteins E; D015415:Biomarkers; D008078:Cholesterol, LDL; D014280:Triglycerides
keywords: Low-density lipoprotein particle size; apolipoproteins; lipid metabolism; triglycerides