title: Mechanisms of Zika Virus Infection and Neuropathogenesis.
abstract: A spotlight has been focused on the mosquito-borne Zika virus (ZIKV) because of its epidemic outbreak in Brazil and Latin America, as well as the severe neurological manifestations of microcephaly and Guillain-Barré syndrome associated with infection. In this review, we discuss the recent literature on ZIKV-host interactions, including new mechanistic insight concerning the basis of ZIKV-induced neuropathogenesis.
authors.affiliation: 1 Lady Davis Institute, Jewish General Hospital, McGill University , Montreal, Canada .
authors.forename: David
authors.initials: D
authors.lastname: Olagnier
authors.affiliation: 2 Istituto Pasteur-Fondazione Cenci Bolognetti , Rome, Italy .
authors.forename: Michela
authors.initials: M
authors.lastname: Muscolini
authors.affiliation: 3 Department of Microbiology and Molecular Genetics, University of Pittsburgh , Pittsburgh, Pennsylvania.
authors.forename: Carolyn B
authors.initials: CB
authors.lastname: Coyne
authors.affiliation: 4 Department of Medicine, Washington University School of Medicine , St. Louis, Missouri.|5 Department of Molecular Microbiology, Washington University School of Medicine , St. Louis, Missouri.|6 Department of Pathology and Immunology, The Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine , St. Louis, Missouri.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Diamond
authors.affiliation: 2 Istituto Pasteur-Fondazione Cenci Bolognetti , Rome, Italy .
authors.forename: John
authors.initials: J
authors.lastname: Hiscott
mesh_terms: D000330:Aedes / Q000821:virology; D000818:Animals; D004196:Disease Outbreaks; D005260:Female; D005333:Fetus; D020275:Guillain-Barre Syndrome / Q000453:epidemiology / Q000209:etiology / Q000473:pathology* / Q000821:virology; D054884:Host-Pathogen Interactions; D006801:Humans; D007843:Latin America / Q000453:epidemiology; D008831:Microcephaly / Q000453:epidemiology / Q000209:etiology / Q000473:pathology* / Q000821:virology; D000072138:Mosquito Vectors / Q000821:virology; D010920:Placenta / Q000473:pathology / Q000821:virology; D011247:Pregnancy; D014771:Virion / Q000472:pathogenicity* / Q000502:physiology; D000071244:Zika Virus / Q000472:pathogenicity* / Q000502:physiology; D000071243:Zika Virus Infection / Q000150:complications* / Q000453:epidemiology / Q000635:transmission / Q000821:virology