title: Palacos compared to Palamed bone cement in total hip replacement: a randomized controlled trial.
abstract: Background and purpose - Stability and survival of cemented total hip prostheses is dependent on a multitude of factors, including the type of cement that is used. Bone cements vary in viscosity, from low to medium and high. There have been few clinical RSA studies comparing the performance of low- and high-viscosity bone cements. We compared the migration behavior of the Stanmore hip stem cemented using novel low-viscosity Palamed bone cement with that of the same stem cemented with conventional high-viscosity Palacos bone cement. Patients and methods - We performed a randomized controlled study involving 39 patients (40 hips) undergoing primary total hip replacement for primary or secondary osteoarthritis. 22 patients (22 hips) were randomized to Palacos and 17 patients (18 hips) were randomized to Palamed. Migration was determined by RSA. Results - None of these 40 hips had been revised at the 10-year follow-up mark. To our knowledge, the patients who died before they reached the 10-year endpoint still had the implant in situ. No statistically significant or clinically significant differences were found between the 2 groups for mean translations, rotations, and maximum total-point motion (MTPM). Interpretation - We found similar migration of the Stanmore stem in the high-viscosity Palacos cement group and the low-viscosity Palamed cement group. We therefore expect that the risk of aseptic loosening with the new Palamed cement would be comparable to that with the conventional Palacos cement. The choice of which type of bone cement to use is therefore up to the surgeon's preference.
authors.affiliation: a Department of Orthopaedics , Leiden University Medical Center (LUMC) , Leiden ;
authors.forename: Joris E
authors.initials: JE
authors.lastname: Meinardi
authors.affiliation: a Department of Orthopaedics , Leiden University Medical Center (LUMC) , Leiden ;|b Department of Biomechanical Engineering, Faculty of Mechanical, Maritime, and Materials Engineering , Delft University of Technology , Delft ;
authors.forename: Edward R
authors.initials: ER
authors.lastname: Valstar
authors.affiliation: a Department of Orthopaedics , Leiden University Medical Center (LUMC) , Leiden ;
authors.forename: Paul
authors.initials: P
authors.lastname: Van Der Voort
authors.affiliation: a Department of Orthopaedics , Leiden University Medical Center (LUMC) , Leiden ;
authors.forename: Bart L
authors.initials: BL
authors.lastname: Kaptein
authors.affiliation: c Department of Medical Statistics and Bioinformatics , Leiden University Medical Center (LUMC) , Leiden ;|d Mathematical Institute, Leiden University , Leiden , the Netherlands.
authors.forename: Marta
authors.initials: M
authors.lastname: Fiocco
authors.affiliation: a Department of Orthopaedics , Leiden University Medical Center (LUMC) , Leiden ;
authors.forename: Rob G H H
authors.initials: RG
authors.lastname: Nelissen
mesh_terms: D000368:Aged; D019644:Arthroplasty, Replacement, Hip / Q000379:methods*; D001843:Bone Cements; D005260:Female; D005500:Follow-Up Studies; D006622:Hip Prosthesis; D006801:Humans; D008297:Male; D019904:Polymethyl Methacrylate; D011474:Prosthesis Design; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D001843:Bone Cements; D019904:Polymethyl Methacrylate