title: The efficacy of pain neuroscience education on musculoskeletal pain: A systematic review of the literature.
abstract: OBJECTIVE
  Systematic review of randomized control trials (RCTs) for the effectiveness of pain neuroscience education (PNE) on pain, function, disability, psychosocial factors, movement, and healthcare utilization in individuals with chronic musculoskeletal (MSK) pain.
  
  
  METHODS
  Systematic searches were conducted on 11 databases. Secondary searching (PEARLing) was undertaken, whereby reference lists of the selected articles were reviewed for additional references not identified in the primary search.
  
  
  METHODS
  All experimental RCTs evaluating the effect of PNE on chronic MSK pain were considered for inclusion. Additional Limitations: Studies published in English, published within the last 20 years, and patients older than 18 years. No limitations were set on specific outcome measures.
  
  
  METHODS
  Data were extracted using the participants, interventions, comparison, and outcomes (PICO) approach.
  
  
  RESULTS
  Study quality of the 13 RCTs used in this review was assessed by 2 reviewers using the PEDro scale. Narrative summary of results is provided for each study in relation to outcomes measurements and effectiveness.
  
  
  CONCLUSIONS
  Current evidence supports the use of PNE for chronic MSK disorders in reducing pain and improving patient knowledge of pain, improving function and lowering disability, reducing psychosocial factors, enhancing movement, and minimizing healthcare utilization.
authors.affiliation: a International Spine and Pain Institute , Story City , IA , USA.
authors.forename: Adriaan
authors.initials: A
authors.lastname: Louw
authors.affiliation: b Department of Physical Therapy, School of Health Sciences , University of South Dakota , Vermillion , SD , USA.
authors.forename: Kory
authors.initials: K
authors.lastname: Zimney
authors.affiliation: c Department of Physical Therapy, School of Allied Health Sciences , University of Nevada, Las Vegas , Las Vegas , NV , USA.
authors.forename: Emilio J
authors.initials: EJ
authors.lastname: Puentedura
authors.affiliation: d Department of Physiotherapy , Stellenbosch University , Stellenbosch , South Africa.
authors.forename: Ina
authors.initials: I
authors.lastname: Diener
mesh_terms: D000293:Adolescent; D000328:Adult; D004185:Disability Evaluation; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D008297:Male; D008875:Middle Aged; D059352:Musculoskeletal Pain / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology / Q000534:rehabilitation*; D059408:Pain Management / Q000379:methods*; D010147:Pain Measurement; D010353:Patient Education as Topic / Q000379:methods*; D026741:Physical Therapy Modalities; D016896:Treatment Outcome; D055815:Young Adult
keywords: Chronic pain; explain pain; pain neuroscience education; therapeutic neuroscience education