title: Clinical Significance of Serum Interleukin-31 and Interleukin-33 Levels in Patients of Endometrial Cancer: A Case Control Study.
abstract: Aims. Previous evidence has proved that interleukin-31 (IL-31) and interleukin-33 (IL-33) can be potential markers in some cancers' formulation. We aimed to determine the potential role of IL-31 and IL-33 in prognosis of endometrial cancer patients. Methods. Serum samples were collected from 160 patients with endometrial cancer and 160 healthy controls. The ELISA kits (Raybio® Systems) specific for human IL-31 and human IL-33 were used. Serum levels of tumor markers (CEA, CA-125, and CA19-9) were measured by chemiluminescence immunoassay. A two-side P value < 0.05 was indicated to be significant. Results. Serum levels of IL-31 and IL-33 in patients were significantly elevated compared to those of healthy controls. The interleukin levels were also related to clinical characteristics, including tumor stages, depth of invasion, and existence of node metastases and distant metastases. The sensitivity and specificity of IL-31 and IL-33 were higher than the counterparts of tumor markers, both separately and in combination of IL-31, IL-33, and the clinical markers. Conclusions. This report is the first one mentioning the possible association between serum IL-31 and IL-33 and endometrial cancer. With their sensitivity and specificity, the interleukins may be useful biomarkers for endometrial cancer's prognosis.
authors.affiliation: Department of Gynecology and Obstetrics, The West China Second University Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu 610041, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Zeng
authors.affiliation: Department of Gynecology and Obstetrics, The West China Second University Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu 610041, China.
authors.forename: Zhu
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Gynecology and Obstetrics, The West China Second University Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu 610041, China.
authors.forename: Qian-Qian
authors.initials: QQ
authors.lastname: Gao
authors.affiliation: Department of Molecular Translational Medicine, The West China Institute of Women and Children's Health, West China Second University Hospital, Sichuan University, Chengdu, China.
authors.forename: Yan-Yun
authors.initials: YY
authors.lastname: Wang
authors.affiliation: Department of Gynecology and Obstetrics, The West China Second University Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu 610041, China.
authors.forename: Xiu-Zhang
authors.initials: XZ
authors.lastname: Yu
authors.affiliation: Department of Molecular Translational Medicine, The West China Institute of Women and Children's Health, West China Second University Hospital, Sichuan University, Chengdu, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhou
authors.affiliation: Department of Gynecology and Obstetrics, The West China Second University Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu 610041, China.
authors.forename: Ming-Rong
authors.initials: MR
authors.lastname: Xi
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000175:diagnosis*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D016889:Endometrial Neoplasms / Q000097:blood / Q000175:diagnosis*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D000067596:Interleukin-33 / Q000097:blood*; D007378:Interleukins / Q000097:blood*; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012372:ROC Curve; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; C502187:IL31 protein, human; C506536:IL33 protein, human; D000067596:Interleukin-33; D007378:Interleukins