title: Theoretical Approaches to Lentiviral Mediated Neurotrophin Delivery in Potential Treatments of Parkinson's Disease.
abstract: Parkinson's disease is a late-onset neurodegenerative disease, characterized by both motor and non-motor symptoms. Motor symptoms include postural instability, rigidity, and tremor, while non-motor symptoms include anxiety, dementia, and depression. In this integrative review, we discuss PD disease pathophysiology in detail and introduce how neurotrophic growth factor delivery via a retroviral-based system can be used as efficacious tools for targeted gene therapy.
authors.affiliation: Institute of Biomaterials and Biomedical Engineering (IBBME), University of Toronto, Toronto, Canada.
authors.forename: Anam
authors.initials: A
authors.lastname: Qudrat
authors.affiliation: Faculty of Applied Science and Engineering, University of Toronto, Toronto, Canada.
authors.forename: Netra
authors.initials: N
authors.lastname: Unni
mesh_terms: D015316:Genetic Therapy; D006801:Humans; D016086:Lentivirus / Q000235:genetics*; D009414:Nerve Growth Factors / Q000235:genetics / Q000502:physiology*; D010300:Parkinson Disease / Q000235:genetics / Q000628:therapy*
chemical_list: D009414:Nerve Growth Factors
keywords: Parkinson’s disease; alpha synuclein; lentivirus; microglia; neurotrophin