title: Anterior Lamina Cribrosa Surface Depth in Open-Angle Glaucoma: Relationship with the Position of the Central Retinal Vessel Trunk.
abstract: OBJECTIVE
  To determine the factors influencing the anterior lamina cribrosa (LC) surface depth (LCD) in patients with open-angle glaucoma (OAG), focusing on the association between LCD and the position of the central retinal vessel trunk (CRVT) at the anterior LC surface.
  
  
  METHODS
  Optic nerve heads of 205 OAG eyes were scanned using swept-source optical coherence tomography (SS-OCT). After processing the images using adaptive compensation, the LCD was determined from 11 horizontal B-scan images that divided the optic disc vertically into 12 equal parts. Eyes were divided into two groups (central or peripheral) according to where the CRVT exits from the anterior LC surface. The influence of CRVT position on LCD was evaluated, taking into account age, gender, untreated intraocular pressure (IOP), IOP at optic-disc scanning, retinal nerve fiber layer (RNFL) thickness, visual-field mean deviation, central corneal thickness, and axial length.
  
  
  RESULTS
  Patients in the peripheral CRVT group were younger and more myopic, and had a larger mean LCD and thinner global RNFL than those in the central CRVT group (all P≤0.023). On multivariate analysis, the peripheral CRVT location was significantly associated with a larger LCD (P = 0.002), together with the significant association of younger age (P<0.001), higher untreated IOP (P = 0.010), and thinner RNFL (P = 0.003) on the larger LCD.
  
  
  CONCLUSIONS
  In OAG, CRVT location was an independent factor influencing the LCD, together with age, untreated IOP, and global RNFL thickness. The data indicate that the CRVT may contribute to the resistance of the LC against deformation. A longitudinal prospective observation is required to clarify this relationship.
authors.affiliation: Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
authors.forename: Baek-Lok
authors.initials: BL
authors.lastname: Oh
authors.affiliation: Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
authors.forename: Eun Ji
authors.identifier: http://orcid.org/0000-0001-9393-9452
authors.initials: EJ
authors.lastname: Lee
authors.affiliation: Department of Applied Statistics, Yonsei University, Seoul, Korea.
authors.forename: Hyunjoong
authors.initials: H
authors.lastname: Kim
authors.affiliation: Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore.|Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
authors.forename: Michaël J A
authors.initials: MJ
authors.lastname: Girard
authors.affiliation: GePaSud, Université de la Polynésie Française, Faaa, French Polynesia.
authors.forename: Jean Martial
authors.initials: JM
authors.lastname: Mari
authors.affiliation: Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
authors.forename: Tae-Woo
authors.initials: TW
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D005260:Female; D005902:Glaucoma, Open-Angle / Q000473:pathology*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D009900:Optic Nerve / Q000473:pathology; D009901:Optic Nerve Diseases; D011446:Prospective Studies; D012030:Refractive Errors; D012171:Retinal Vessels / Q000473:pathology*; D055815:Young Adult