title: A Genetic Variant rs1020760at NFKB1 is Associated with Clinical Features of Psoriasis Vulgaris in a Han Chinese Population.
abstract: Psoriasis vulgaris is a chronic inflammatory skin disease associated with complex genetic susceptibility. Recently, we identified a single-nucleotide variant rs1020760 at NFKB1 significantly associated with psoriasis in a Han Chinese population in deep analysis of exome and targeted sequencing (P = 1.76 × 10(-8) ). To investigate the potential association between rs1020760 and phenotypes of psoriasis vulgaris, we performed a genotype-phenotype analysis. A total of 9946 cases and 9906 controls with detailed clinical and demographic information were involved in this study, while the genotype data of rs1020760 was available in the previous targeted sequencing study of psoriasis. Genotype-based association testing revealed the additive model might provide the best fit for rs1020760 (P = 5.44 × 10(-8) ). Case-only analysis showed that the distribution of allele G was significantly different between the cases with and without family history (Pallele = 4.07 × 10(-3) ,Pgenotype = 5.75 × 10(-3) ). The differences in allele and genotype frequencies were observed between all the subphenotypes and controls except for the genotype frequency of the late onset subgroup, while no difference was found in case-only analysis for the other two subphenotypes. Rs1020760 was preferentially associated with family history of psoriasis, implying that NFKB1 might not only play important roles in the development of psoriasis, but might also contribute to the special phenotypes of this disease.
authors.affiliation: Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Wang
authors.affiliation: Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China.
authors.forename: Zhengwei
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China.
authors.forename: Caihong
authors.initials: C
authors.lastname: Zhu
authors.affiliation: Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Zheng
authors.affiliation: Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China.
authors.forename: Xianbo
authors.initials: X
authors.lastname: Zuo
authors.affiliation: Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.affiliation: Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China.
authors.forename: Fusheng
authors.initials: F
authors.lastname: Zhou
authors.affiliation: Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Liang
authors.affiliation: Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China.
authors.forename: Huayang
authors.initials: H
authors.lastname: Tang
authors.affiliation: Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China.
authors.forename: Zaixing
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China.
authors.forename: Xuejun
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China.
authors.forename: Liangdan
authors.initials: L
authors.lastname: Sun
mesh_terms: D000328:Adult; D017668:Age of Onset; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D052002:NF-kappa B p50 Subunit / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011565:Psoriasis / Q000235:genetics*
chemical_list: D052002:NF-kappa B p50 Subunit; C489548:NFKB1 protein, human
keywords: Genotype; NFKB1; phenotype; psoriasis vulgaris