title: Synthesis of 1-Substituted Isoquinolines by Heterocyclization of TosMIC Derivatives: Total Synthesis of Cassiarin A.
abstract: A new method for the synthesis of 1-substituted isoquinolines by a heterocyclization that involves α-benzyl TosMIC derivatives and different electrophiles has been developed. This methodology has been successfully applied to a total synthesis of cassiarin A, an alkaloid with potent antiplasmodial activity against Plasmodium falciparum.
authors.affiliation: Departamento de Química Orgánica y Química Inorgánica, Universidad de Alcalá , Alcalá de Henares 28871, Spain.
authors.forename: Sara
authors.initials: S
authors.lastname: Gutiérrez
authors.affiliation: Departamento de Química Orgánica y Química Inorgánica, Universidad de Alcalá , Alcalá de Henares 28871, Spain.
authors.forename: Anna
authors.initials: A
authors.lastname: Coppola
authors.affiliation: Departamento de Química Orgánica y Química Inorgánica, Universidad de Alcalá , Alcalá de Henares 28871, Spain.
authors.forename: David
authors.initials: D
authors.lastname: Sucunza
authors.affiliation: Departamento de Química Orgánica y Química Inorgánica, Universidad de Alcalá , Alcalá de Henares 28871, Spain.
authors.forename: Carolina
authors.initials: C
authors.lastname: Burgos
authors.affiliation: Departamento de Química Orgánica y Química Inorgánica, Universidad de Alcalá , Alcalá de Henares 28871, Spain.
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Vaquero