title: Good's syndrome: Is thymectomy the solution? Case report and literature review.
abstract: Good's syndrome is thymoma accompanied by immunodeficiency. A 69-year-old woman presented with recurrent chest infections, hypogammaglobulinemia, and radiological features of a thymoma. Immunoglobulin replacement therapy was not tolerated prior to surgery. Postoperative recovery was uneventful, and a Masaoka stage II type AB thymoma was confirmed on histology. One-year follow-up revealed no recurrence of the thymoma but the patient remained hypogammaglobulinemic and developed collagenous colitis. She declined immunoglobulin replacement therapy but remains under follow-up. Awareness of Good's syndrome to avoid overwhelming infection is emphasized. The finding of thymoma should prompt the thoracic surgeon to test for immunodeficiency.
authors.affiliation: Department of Cardiothoracic Surgery, Castle Hill Hospital, Cottingham, UK Department of Cardiothoracic Surgery, Ain Shams University Hospitals, Cairo, Egypt habibmos@gmail.com.
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Habib
authors.affiliation: Department of Cardiothoracic Surgery, Castle Hill Hospital, Cottingham, UK.
authors.forename: Hilary
authors.initials: H
authors.lastname: Thornton
authors.affiliation: Department of Immunology, Scunthorpe General Hospital, Scunthorpe, UK.
authors.forename: Wa Carrock
authors.initials: WC
authors.lastname: Sewell
authors.affiliation: Department of Cardiothoracic Surgery, Castle Hill Hospital, Cottingham, UK.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Loubani
mesh_terms: D000361:Agammaglobulinemia / Q000150:complications* / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D000368:Aged; D046729:Colitis, Collagenous / Q000209:etiology / Q000276:immunology; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D009367:Neoplasm Staging; D012008:Recurrence; D012141:Respiratory Tract Infections / Q000209:etiology / Q000276:immunology; D013934:Thymectomy; D013945:Thymoma / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D013953:Thymus Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
keywords: Immunity; Immunologic deficiency syndromes; Thymoma; Thymus Neoplasms; cellular