title: Detection and Clinical Significance of COX-2 Gene SNPs in Gastric Cancer.
abstract: Gastric cancer has high morbidity and mortality. Identification of patients with high gastric cancer risk at early stage will improve patient prognosis. In this study, we examined two single nucleotide polymorphism (SNP) sites of COX-2 gene in gastric cancer patients and explored the effect of the SNPs on the morbidity of gastric cancer. We found that the SNPs COX-2-1195G/A and COX-2-8473T/C are correlated with the occurrence of gastric cancer, and the patients with variants A and C of the SNPs are liable to have gastric cancer. Our study provides a potential method for screening of susceptible population of gastric cancer for early-stage intervention in patients.
authors.affiliation: Department of Clinical Laboratory, The People's Hospital of Wenshan Prefecture, No. 228, Kaihua Middle Road, Wenshan City, 663000, Yunnan, China. drluxingre@163.com.
authors.forename: Xingre
authors.initials: X
authors.lastname: Lu
authors.affiliation: Department of Clinical Laboratory, The People's Hospital of Wenshan Prefecture, No. 228, Kaihua Middle Road, Wenshan City, 663000, Yunnan, China.
authors.forename: Fengyu
authors.initials: F
authors.lastname: Chen
authors.affiliation: Department of Clinical Laboratory, The People's Hospital of Wenshan Prefecture, No. 228, Kaihua Middle Road, Wenshan City, 663000, Yunnan, China.
authors.forename: Xiaowen
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Clinical Laboratory, The People's Hospital of Wenshan Prefecture, No. 228, Kaihua Middle Road, Wenshan City, 663000, Yunnan, China.
authors.forename: Diao
authors.initials: D
authors.lastname: Yuan
authors.affiliation: Department of Clinical Laboratory, The People's Hospital of Wenshan Prefecture, No. 228, Kaihua Middle Road, Wenshan City, 663000, Yunnan, China.
authors.forename: Yunju
authors.initials: Y
authors.lastname: Zi
authors.affiliation: Department of Clinical Laboratory, The People's Hospital of Wenshan Prefecture, No. 228, Kaihua Middle Road, Wenshan City, 663000, Yunnan, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: He
authors.affiliation: Department of Clinical Laboratory, The People's Hospital of Wenshan Prefecture, No. 228, Kaihua Middle Road, Wenshan City, 663000, Yunnan, China.
authors.forename: Running
authors.initials: R
authors.lastname: He
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics; D016022:Case-Control Studies; D051546:Cyclooxygenase 2 / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human
keywords: COX-2 gene; Gastric cancer; Genetic susceptibility; Single nucleotide polymorphism