title: MT5-MMP, just a new APP processing proteinase in Alzheimer's disease?
abstract: We have recently identified in a transgenic mouse model of Alzheimer's disease (AD) membrane-type 5-MMP (MT5-MMP) as a new player in Alzheimer's pathogenesis, which displays pro-amyloidogenic features and proteolytic processing of amyloid precursor protein (APP). Another group has reported that MT5-MMP processing of APP may release a novel neurotoxic APP fragment. Although MT5-MMP-mediated APP processing appears to be a key pathogenic step, we hypothesize that MT5-MMP may also contribute to AD pathogenesis through complementary mechanisms that involve the activation of pro-inflammatory pathways and/or APP trafficking.
authors.affiliation: Aix Marseille Univ, CNRS, NICN, Marseille, France.
authors.forename: Kévin
authors.initials: K
authors.lastname: Baranger
authors.affiliation: Aix Marseille Univ, CNRS, NICN, Marseille, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Khrestchatisky
authors.affiliation: Aix Marseille Univ, CNRS, NICN, Marseille, France. santiago.rivera@univ-amu.fr.
authors.forename: Santiago
authors.identifier: 0000-0001-6649-2712
authors.initials: S
authors.lastname: Rivera
mesh_terms: D000544:Alzheimer Disease / Q000139:chemically induced* / Q000235:genetics*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D053504:Matrix Metalloproteinases, Membrane-Associated / Q000378:metabolism* / Q000633:toxicity*; D051379:Mice; D008822:Mice, Transgenic
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D016207:Cytokines; D053504:Matrix Metalloproteinases, Membrane-Associated; C118502:Mmp24 protein, mouse
keywords: Amyloid precursor protein; Amyloidogenesis; IL-1β; Matrix metalloproteinases; Neurodegenerative disease; Neuroinflammation; Trafficking