title: Selenium nanoparticles as a nutritional supplement.
abstract: Selenium is an essential trace element in the diet, required for maintenance of health and growth; however, its toxicity could cause serious damage depending on dose and chemical form. Selenium nanoparticles (SeNPs) represent what we believe to be a novel prospect for nutritional supplementation because of their lower toxicity and ability to gradually release selenium after ingestion. In this review, we discuss various forms and types of SeNPs, as well as the way they are synthesized. We also discuss absorption and bioavailability of nanoparticles within the organism. SeNPs demonstrate anticancer and antimicrobial properties that may contribute to human health, not only as dietary supplements, but also as therapeutic agents.
authors.affiliation: Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic; Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Skalickova
authors.affiliation: Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic; Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic.
authors.forename: Vedran
authors.initials: V
authors.lastname: Milosavljevic
authors.affiliation: Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic; Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic.
authors.forename: Kristyna
authors.initials: K
authors.lastname: Cihalova
authors.affiliation: Department of Animal Nutrition and Forage Production, Faculty of Agronomy, Mendel University in Brno, Brno, Czech Republic.
authors.forename: Pavel
authors.initials: P
authors.lastname: Horky
authors.affiliation: Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic; Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic.
authors.forename: Lukas
authors.initials: L
authors.lastname: Richtera
authors.affiliation: Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic; Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic. Electronic address: Vojtech.adam@mendelu.cz.
authors.forename: Vojtech
authors.initials: V
authors.lastname: Adam
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D019587:Dietary Supplements; D006801:Humans; D053758:Nanoparticles; D012643:Selenium / Q000008:administration & dosage* / Q000494:pharmacology; D014131:Trace Elements / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D014131:Trace Elements; D012643:Selenium
keywords: Antimicrobial activity; Cancer; Diet; Nanoselenium; Supplementation; Toxicity