title: Protective effects of ethanol extract from Portulaca oleracea L on dextran sulphate sodium-induced mice ulcerative colitis involving anti-inflammatory and antioxidant.
abstract: Portulaca oleracea L., (POL) is one of commonly used medicine-food herbs and has a cosmopolitan distribution in many countries. Many studies showed that POL exhibited a wide range of pharmacological effects such as anti-inflammatory and liver complaints. In the clinical studies, POL was usually used for the treatment of UC disease and the clinical efficacy was well, but the mechanism and scientific intension was still unknown. In the present study, we studied the protective effects of the ethanol extract from POL on dextran sulphate sodium-induced UC in C57BL/6 mice model through oxidative stress and inflammatory pathway. The results demonstrated that the ethanol extract from POL could exhibit the effective protection for the DSS induced UC by increasing the colon length, decreasing body weight loss and the disease activity index score, inhibiting oxidative stress response through the MDA, NO, SOD activities, reducing the mRNA expressions of pro-inflammatory cytokines (TNF-α, IL-1β and IL-6) and the protein expressions of TNF-α and NF-kB p65. These results may prove that POL could be considered as a useful and effective botanical compound from the edible plant to be used in UC through the oxidative stress and inflammatory activities.
authors.affiliation: Department of Medical Technology, Shaanxi University of Chinese Medicine Shaanxi, Xianyang 712046, China.
authors.forename: Xiaohang
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Chinese Traditional Medicine, Shaanxi University of Chinese Medicine Shaanxi, Xianyang 712046, China.
authors.forename: Yongmei
authors.initials: Y
authors.lastname: Yan
authors.affiliation: Department of Pharmacy, Xijing Hospital, Fourth Military Medical University Shaanxi, Xi'an 710032, China.
authors.forename: Jiankang
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Pharmacy, Shaanxi University of Chinese Medicine Shaanxi, Xianyang 712046, China.
authors.forename: Zhishu
authors.initials: Z
authors.lastname: Tang
authors.affiliation: Department of Pharmacy, Shaanxi University of Chinese Medicine Shaanxi, Xianyang 712046, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Sun
authors.affiliation: Department of Chinese Traditional Medicine, Shaanxi University of Chinese Medicine Shaanxi, Xianyang 712046, China.
authors.forename: Huan
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Chinese Traditional Medicine, Shaanxi University of Chinese Medicine Shaanxi, Xianyang 712046, China.
authors.forename: Siyang
authors.initials: S
authors.lastname: Hao
authors.affiliation: Department of Pharmacy, Xijing Hospital, Fourth Military Medical University Shaanxi, Xi'an 710032, China.
authors.forename: Aidong
authors.initials: A
authors.lastname: Wen
authors.affiliation: Department of Chinese Traditional Medicine, Shaanxi University of Chinese Medicine Shaanxi, Xianyang 712046, China.
authors.forename: Li
authors.initials: L
authors.lastname: Liu
keywords: Portulaca oleracea L; Ulcerative colitis; anti-inflammation; antioxidation