title: Multiple roles of CD90 in cancer.
abstract: THY1 (CD90) is a 25-37-kDa heavily N-glycosylated, glycophosphatidylinositol (GPI) anchored cell surface protein. It is usually expressed on thymocytes, mesenchymal stem cells, hematopoietic stem cells, natural killer cells, neurons, endothelial cells, renal glomerular mesangial cells, follicular dendritic cells, fibroblasts, and myofibroblasts. It has been found to regulate cell adhesion, migration, apoptosis, axon growth, cell-cell and cell-matrix interactions, T-cell activation, and fibrosis. Several reports have shown that CD90 has an important role in cancer in regulating cancer cell proliferation, metastasis, and angiogenesis. There are also evidences that CD90 is an important prognostic marker in many cancers. Consequently, therapies that target CD90 have great promise in treating many cancers. However, several studies also indicate a contradictory role for CD90, where it acts as a tumor suppressor. In this review, we summarize the expression, function of CD90 in different cancers and its possible use as a biomarker or a therapeutic target in cancer. The challenges and future prospects for the use of CD90 for clinical applications are also discussed in this review.
authors.affiliation: Stem Cell and Cancer Biology Group, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, India.
authors.forename: Atul
authors.initials: A
authors.lastname: Kumar
authors.affiliation: Stem Cell and Cancer Biology Group, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, India.
authors.forename: Anshuman
authors.initials: A
authors.lastname: Bhanja
authors.affiliation: Department of Hematology, Gauhati Medical College Hospital, Guwahati, Assam, India.
authors.forename: Jina
authors.initials: J
authors.lastname: Bhattacharyya
authors.affiliation: Stem Cell and Cancer Biology Group, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, India. bithiahgj@iitg.ernet.in.
authors.forename: Bithiah Grace
authors.initials: BG
authors.lastname: Jaganathan
mesh_terms: D014408:Biomarkers, Tumor; D006801:Humans; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000209:etiology* / Q000473:pathology; D017154:Stromal Cells / Q000737:chemistry; D018800:Thy-1 Antigens / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D025521:Tumor Suppressor Proteins / Q000502:physiology
chemical_list: D014408:Biomarkers, Tumor; D018800:Thy-1 Antigens; D025521:Tumor Suppressor Proteins
keywords: Biomarker; CD90; Cancer; Metastasis; Microenvironment; Prognosis; Stem cells; Therapy