title: Denosumab for Treatment of a Recurrent Cervical Giant-Cell Tumor.
abstract: A 43-year-old male patient with C5 giant cell tumor (GCT) underwent tumor resection and anterior bone fusion of C4-C6. The tumor recurred locally 9 months after surgery with the patient complaining of neck and shoulder pain similar to his preoperative symptoms. Denosumab was administered and his pain disappeared after a two-month administration, with a sclerotic rim formation seen at the tumor site on computed tomography. He has been followed for 18 months with no evidence of tumor recurrence. Complete resection is generally recommended, but is not easy for many patients with cervical GCT because of the existence of neurovascular structures. Some patients suffer from recurrence and treatment becomes more difficult. As such, denosumab may be an efficacious option for treatment of recurrent GCT of the cervical spine, although long-term follow-up is required to monitor for presence or absence of recurrence.
authors.affiliation: Department of Orthopedic Surgery, Chiba Cancer Center, Chiba, Japan.; Department of Orthopedic Surgery, Chiba University, Chiba, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kajiwara
authors.affiliation: Department of Orthopedic Surgery, Chiba Cancer Center, Chiba, Japan.
authors.forename: Hiroto
authors.initials: H
authors.lastname: Kamoda
authors.affiliation: Department of Orthopedic Surgery, Chiba Cancer Center, Chiba, Japan.
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Yonemoto
authors.affiliation: Department of Orthopedic Surgery, Chiba Cancer Center, Chiba, Japan.
authors.forename: Shintaro
authors.initials: S
authors.lastname: Iwata
authors.affiliation: Department of Orthopedic Surgery, Chiba Cancer Center, Chiba, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ishii
authors.affiliation: Department of Orthopedic Surgery, Chiba Cancer Center, Chiba, Japan.; Department of Orthopedic Surgery, Tsukuba University, Ibaraki, Japan.
authors.forename: Toshinori
authors.initials: T
authors.lastname: Tsukanishi
authors.affiliation: Department of Orthopedic Surgery, Chiba University, Chiba, Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Ohtori
authors.affiliation: Department of Orthopedic Surgery, Tsukuba University, Ibaraki, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Yamazaki
authors.affiliation: Department of Orthopedic Surgery, National Hospital Organization Chiba Medical Center, Chiba, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Okawa
keywords: Cervical vertebrae; Denosumab; Giant cell tumor of bone; Recurrence