title: [Advances in Liquid Biopsy and its Clinical Application in the Diagnosis  and Treatment of Non-small Cell Lung Cancer].
abstract: With the advances of technology, great progresses have been made in liquid biopsy in recent years. Liquid biopsy is currently playing a more and more important role in early diagnosis and treatment of cancer. Compared with traditional tissue biopsy, liquid biopsy is more popular in clinical practice due to its non-invasiveness, convenience and high repeatability. It has huge potential in the future. This review introduces circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) as the most important objects in liquid biopsy, mainly focusing on their history, biological characteristics, detection technologies, limitations and applications in non-small cell lung cancer.
authors.affiliation: Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
authors.forename: Difan
authors.initials: D
authors.lastname: Zheng
authors.affiliation: Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
authors.forename: Haiquan
authors.initials: H
authors.lastname: Chen
mesh_terms: D001706:Biopsy / Q000379:methods*; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy