title: Malignant melanoma arising in a mature teratoma: A case report with review of the recent literature.
abstract: Mature cystic teratomas constitute 10-20% of all ovarian neoplasms. Malignant transformation is very rare occurring in only 0.1-2% of mature teratoma cases. Malignant melanoma is among the least common transformations. Herein, we describe a case of young woman initially undergoing evaluation for infertility who was found to have malignant melanoma arising in a mature dermoid cyst. She subsequently underwent unilateral salpingo-oophorectomy with staging procedure with benign pathology. There was no need for adjuvant therapy and the patient is without disease to date (nearly 10-months in follow-up now). We reviewed the existing literature and this is one of only a few cases documented in the last decade.
authors.affiliation: Florida Hospital Gynecologic Oncology, Orlando, FL 32804, USA.
authors.forename: Lorna A
authors.initials: LA
authors.lastname: Brudie
authors.affiliation: Florida Hospital Gynecologic Oncology, Orlando, FL 32804, USA.
authors.forename: Faizan
authors.initials: F
authors.lastname: Khan
authors.affiliation: Department of Pathology, Orlando, FL 32804, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Radi
authors.affiliation: Advanced Reproductive Endocrinology Specialists, Florida Hospital Cancer Institute, Orlando, FL 32804, USA.
authors.forename: Melissa M
authors.initials: MM
authors.lastname: Yates
authors.affiliation: Florida Hospital Gynecologic Oncology, Orlando, FL 32804, USA.
authors.forename: Sarfraz
authors.initials: S
authors.lastname: Ahmad
keywords: Dermoid; Literature review; Malignant melanoma; Mature teratoma; Prognosis; Treatments