title: An Efficient and Facile Synthesis of 1,2,4-Aryl Triazoles and 4-Thiazolidinones Bearing 6-Fluorochroman Nucleus.
abstract: A new generation of chroman bearing heterocyclic five membered ring such as 1,2,4-triazoles and thiazolidinones was designed and synthesized. New chroman based nucleus 5-(6-fluorochroman-2-yl)-4-aryl-4H-1,2,4-triazole-3-thiol and 6-fluorochroman-N-(4-oxo-2-arylthiazolidinin-3-yl) chroman-2-carboxamides were synthesized. Aryl triazole compounds 4a-4j were synthesized from 6-fluorochroman-2-carbohydrazide 2 on reaction with base in methanol and CS2 followed by reaction with substituted aniline. Thiazolidinone compounds 5a-5j were synthesized from 6-fluorochroman-2-carbohydrazide 2 on reaction with substituted aryl aldehyde and thioglycolic acid.
authors.affiliation: Chemical Research Laboratory, Department of Chemistry, Saurashtra University, Rajkot 360005, India.
authors.forename: Piyush B
authors.initials: PB
authors.lastname: Vekariya
authors.affiliation: Chemical Research Laboratory, Department of Chemistry, Saurashtra University, Rajkot 360005, India.
authors.forename: Jalpa R
authors.initials: JR
authors.lastname: Pandya
authors.affiliation: Chemical Research Laboratory, Department of Chemistry, Saurashtra University, Rajkot 360005, India.
authors.forename: Hitendra S
authors.initials: HS
authors.lastname: Joshi