title: Highly enantioselective [3+2] coupling of cyclic enamides with quinone monoimines promoted by a chiral phosphoric acid.
abstract: Enantioselective [3+2] coupling of cyclic enamides with quinone monoimines was realised using a chiral phosphoric acid as a catalyst. This transformation allowed for the synthesis of highly enantioenriched polycyclic 2,3-dihydrobenzofurans (up to 99.9% ee). The absolute configuration of one product was determined by an X-ray crystal structural analysis. We also found a possible mechanism for this reaction.
authors.affiliation: Key Laboratory for Asymmetric Synthesis and Chiraltechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, China. xmzhang@cioc.ac.cn and University of Chinese Academy of Sciences, Beijing, China.
authors.forename: Minmin
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Key Laboratory for Asymmetric Synthesis and Chiraltechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, China. xmzhang@cioc.ac.cn and University of Chinese Academy of Sciences, Beijing, China.
authors.forename: Shuowen
authors.initials: S
authors.lastname: Yu
authors.affiliation: Key Laboratory for Asymmetric Synthesis and Chiraltechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, China. xmzhang@cioc.ac.cn and University of Chinese Academy of Sciences, Beijing, China.
authors.forename: Fangzhi
authors.initials: F
authors.lastname: Hu
authors.affiliation: Key Laboratory for Asymmetric Synthesis and Chiraltechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, China. xmzhang@cioc.ac.cn and University of Chinese Academy of Sciences, Beijing, China.
authors.forename: Yijun
authors.initials: Y
authors.lastname: Liao
authors.affiliation: Key Laboratory for Asymmetric Synthesis and Chiraltechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, China. xmzhang@cioc.ac.cn and University of Chinese Academy of Sciences, Beijing, China.
authors.forename: Lihua
authors.initials: L
authors.lastname: Liao
authors.affiliation: Key Laboratory for Asymmetric Synthesis and Chiraltechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, China. xmzhang@cioc.ac.cn.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Xu
authors.affiliation: Key Laboratory for Asymmetric Synthesis and Chiraltechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, China. xmzhang@cioc.ac.cn.
authors.forename: Weicheng
authors.initials: W
authors.lastname: Yuan
authors.affiliation: Key Laboratory for Asymmetric Synthesis and Chiraltechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, China. xmzhang@cioc.ac.cn.
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Zhang