title: Therapeutic Drug Monitoring of Posaconazole: an Update.
abstract: Posaconazole is a second-generation triazole agent with a potent and broad antifungal activity. In addition to the oral suspension, a delayed-release tablet and intravenous formulation with improved pharmacokinetic properties have been introduced recently. Due to the large interindividual and intraindividual variation in bioavailability and drug-drug interactions, therapeutic drug monitoring (TDM) is advised to ensure adequate exposure and improve clinical response for posaconazole. Here, we highlight and discuss the most recent findings on pharmacokinetics and pharmacodynamics of posaconazole in the setting of prophylaxis and treatment of fungal infections and refer to the challenges associated with TDM of posaconazole.
authors.affiliation: Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.
authors.forename: Bart G J
authors.initials: BGJ
authors.lastname: Dekkers
authors.affiliation: Department of Hematology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
authors.forename: Martijn
authors.initials: M
authors.lastname: Bakker
authors.affiliation: Department of Clinical Pharmacy, ZGT Hospital Group Twente, Hengelo, The Netherlands.
authors.forename: Kim C M
authors.initials: KCM
authors.lastname: van der Elst
authors.affiliation: Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.
authors.forename: Marieke G G
authors.initials: MGG
authors.lastname: Sturkenboom
authors.affiliation: Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.
authors.forename: Anette
authors.initials: A
authors.lastname: Veringa
authors.affiliation: Department of Hematology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
authors.forename: Lambert F R
authors.initials: LFR
authors.lastname: Span
authors.affiliation: Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.
authors.forename: Jan-Willem C
authors.initials: JC
authors.lastname: Alffenaar
keywords: Dried blood spot; Fusarium infections; Invasive aspergillosis; Invasive fungal infection; Mucormycosis; Pharmacodynamics; Pharmacokinetics; Posaconazole; Prophylaxis; Scedosporium infections; Therapeutic drug monitoring