title: Membrane property and biofunction of phospholiposome incorporated with anomeric galactolipids.
abstract: There has been increasing interest in the construction of liposomes containing a targeting reagent for target-specific drug delivery. Glycoconjugates that can be recognized by transmembrane glycoprotein receptors have been extensively used to form glyco-liposomal drug carriers. However, the impact of anomerism, which is a common identity of natural glycoconjugates, on the glyco-liposomal properties has been hardly probed in previous studies. Here we investigate the liposomal properties of phospholipid incorporated with a pair of anomeric galactolipids. The anomeric galacto-liposomes are characterized and their membrane fluidity, thermo-stability, DNA condensation efficiency and fluorescence leakage are comparatively tested. The in vitro cellular internalization effect of the galacto-liposomes is also demonstrated. This study suggests that anomerism might give distinct impact on the membrane properties and even biofunctions of glyco-liposomes.
authors.affiliation: Key Laboratory for Advanced Materials and Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Rd, Shanghai, 200237 People's Republic of China.
authors.forename: Danyang
authors.initials: D
authors.lastname: Liu
authors.affiliation: Key Laboratory of Medical Molecular Virology (Ministry of Health and Ministry of Education), School of Basic Medical Sciences, Fudan University, 138 Yixueyuan Rd, Shanghai, 200032 People's Republic of China.
authors.forename: Junqi
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Key Laboratory for Advanced Materials and Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Rd, Shanghai, 200237 People's Republic of China.
authors.forename: Shouhong
authors.initials: S
authors.lastname: Xu
authors.affiliation: Key Laboratory for Advanced Materials and Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Rd, Shanghai, 200237 People's Republic of China.
authors.forename: Honglai
authors.initials: H
authors.lastname: Liu
keywords: DNA condensation; Glycolipid; Hybrid liposome; Interfacial behaviour