title: Primary synovial sarcoma of the thyroid with locally repeated relapses in short periods: A case report.
abstract: The primary occurrence of synovial sarcoma (SS) in the thyroid is quite rare. As other SS arise from the head and neck structure, it tends to present poor biological behaviors and is generally treated as a high-grade sarcoma. The present study reports the case of a 31-year-old male who presented a neck mass, involving the thyroid, as shown by ultrasonography. The tumor was resected by total thyroidectomy and diagnosed as SS by histopathology. However, the initial surgery was considered as incomplete (R2) and no adjuvant protocol was followed. At the follow-up, neck recurrences within local lymph nodes were found repeatedly. The tumor grade increased for the metastatic lesions, indicating poorer differentiations with repeated relapses. The accurate evaluations of the primary tumor facilitated it to tailor the initial treatments, otherwise, the prognosis may be deteriorated by inappropriate management.
authors.affiliation: Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, P.R. China; Department of General Surgery, Minhang Hospital, Fudan University, Shanghai 201199, P.R. China.
authors.forename: Rong-Liang
authors.initials: RL
authors.lastname: Shi
authors.affiliation: Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China.
authors.forename: Ning
authors.initials: N
authors.lastname: Qu
authors.affiliation: Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, P.R. China; Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China.
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Gao
authors.affiliation: Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China.
authors.forename: Zhong-Wu
authors.initials: ZW
authors.lastname: Lu
authors.affiliation: Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China.
authors.forename: Guo-Hua
authors.initials: GH
authors.lastname: Sun
authors.affiliation: Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China.
authors.forename: Qing-Hai
authors.initials: QH
authors.lastname: Ji
keywords: neoplasm; prognosis; synovial sarcoma; thyroid gland; treatment