title: Antimelanoma effect of Salmonella Typhimurium integration host factor mutant in murine model.
abstract: OBJECTIVE
  This study aimed to evaluate an attenuated Salmonella ihfA-null mutant strain as therapeutic agent to control tumor growth.
  
  
  METHODS
  After bacterial toxicity evaluation, C57BL/6JUnib mice were inoculated with B16F10 cells and treated with two Salmonella strains (LGBM 1.1 and LGBM 1.41).
  
  
  RESULTS
  LGBM 1.1 can reduce tumor mass, but it exerts some toxic effects. Although LGBM 1.41 is less toxic than LGBM 1.1, it does not reduce tumor mass significantly. Indeed, animals treated with LGBM 1.41 present only slightly initial delay in tumor progression and increased survival rate as compared with the control.
  
  
  CONCLUSIONS
  The null-mutants of ihfA gene of Salmonella Typhimurium could be a promising candidate for melanoma treatment.
authors.affiliation: Department of Genetics, Evolution & Bioagents, Institute of Biology, University of Campinas - UNICAMP, Campinas, São Paulo, Brazil.
authors.forename: Catierine
authors.initials: C
authors.lastname: Hirsch Werle
authors.affiliation: Department of Genetics, Evolution & Bioagents, Institute of Biology, University of Campinas - UNICAMP, Campinas, São Paulo, Brazil.
authors.forename: Igor
authors.initials: I
authors.lastname: Damiani
authors.affiliation: Department of Genetics, Evolution & Bioagents, Institute of Biology, University of Campinas - UNICAMP, Campinas, São Paulo, Brazil.
authors.forename: Guilherme
authors.initials: G
authors.lastname: Paier Milanez
authors.affiliation: Department of Genetics, Evolution & Bioagents, Institute of Biology, University of Campinas - UNICAMP, Campinas, São Paulo, Brazil.
authors.forename: Alessandro S
authors.initials: AS
authors.lastname: Farias
authors.affiliation: Department of Structural & Functional Biology, Institute of Biology, University of Campinas, Sao Paulo, Brazil.
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Cintra Gomes Marcondes
authors.affiliation: Laboratory of Genetics, Butantan Institute, Av. Vital Brasil, 1500, 05503-900, São Paulo, SP, Brazil.
authors.forename: Hebert
authors.initials: H
authors.lastname: Fabricio Culler
authors.affiliation: Laboratory of Genetics, Butantan Institute, Av. Vital Brasil, 1500, 05503-900, São Paulo, SP, Brazil.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Palma Sircili
authors.affiliation: Department of Genetics, Evolution & Bioagents, Institute of Biology, University of Campinas - UNICAMP, Campinas, São Paulo, Brazil.
authors.forename: Bruna
authors.initials: B
authors.lastname: Leite
authors.affiliation: Department of Genetics, Evolution & Bioagents, Institute of Biology, University of Campinas - UNICAMP, Campinas, São Paulo, Brazil.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Brocchi
mesh_terms: D000818:Animals; D058491:Bacterial Load; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D034982:Integration Host Factors / Q000235:genetics*; D008545:Melanoma / Q000382:microbiology* / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D008546:Melanoma, Experimental; D051379:Mice; D050505:Mutant Proteins; D012480:Salmonella Infections / Q000382:microbiology*; D012486:Salmonella typhimurium / Q000235:genetics*; D017384:Sequence Deletion; D047368:Tumor Burden
chemical_list: D034982:Integration Host Factors; D050505:Mutant Proteins; C440508:integration host factor, Salmonella
keywords: Salmonella enterica Typhimurium; cancer treatment; skin (melanoma)