title: Laboratory Diagnosis of Factor XIII Deficiency in Developing Countries: An Iranian Experience.
abstract: Factor XIII (FXIII) deficiency is an extremely rare bleeding disorder with an approximately 12-times higher than the rest of the world. The International Society for Thrombosis and Hemostasis (ISTH) suggested a standard algorithm for precise diagnosis and classification of FXIII deficiency (FXIIID). However, due to lack of investment in proper equipment and procedures in Iran, almost no part of this algorithm can be used to diagnose Iranian patients. Thus, this study proposes a guideline for accurate molecular and laboratory diagnosis of FXIIID based on the available tools. Because this study suggests a simple and reliable algorithm for early diagnosis, it can therefore, reduce the rates of morbidity and mortality of FXIIID patients with this condition.
authors.affiliation: Department of Hematology and Blood Transfusion, School of Allied Medical Science, Iran University of Medical Sciences, Tehran, dorgalaleha@gmail.com.
authors.forename: Akbar
authors.initials: A
authors.lastname: Dorgalaleh
authors.affiliation: Department of Hematology and Blood Transfusion, School of Allied Medical Science, Iran University of Medical Sciences, Tehran.
authors.forename: Shadi
authors.initials: S
authors.lastname: Tabibian
authors.affiliation: Department of Hematology and Blood Transfusion, School of Allied Medical Science, Iran University of Medical Sciences, Tehran, Department of Laboratory Sciences, Paramedical Faculty, Babol University of Medical Sciences, Babol, and.
authors.forename: Mahmood
authors.initials: M
authors.lastname: Shams
authors.affiliation: Department of Hematology and Blood Transfusion, School of Allied Medical Science, Iran University of Medical Sciences, Tehran.
authors.forename: Behnaz
authors.initials: B
authors.lastname: Tavasoli
authors.affiliation: Department of Hematology and Blood Transfusion, School of Allied Medical Science, Iran University of Medical Sciences, Tehran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Gheidishahran
authors.affiliation: School of Nursing and Midwifery, Shahroud University of Medical Sciences, Shahroud, Iran.
authors.forename: Morteza
authors.initials: M
authors.lastname: Shamsizadeh
mesh_terms: D000465:Algorithms; D019411:Clinical Laboratory Techniques / Q000379:methods*; D003906:Developing Countries; D005177:Factor XIII Deficiency / Q000000981:diagnostic imaging*; D006801:Humans; D007492:Iran
keywords: ISTH; Iran; developing countries; factor XIII deficiency; laboratory diagnosis; rare bleeding disorders