title: Spatial Partitioning of miRNAs Is Related to Sequence Similarity in Overall Transcriptome.
abstract: RNAs have been shown to exhibit differential enrichment between nuclear, cytoplasmic, and exosome fractions. A current fundamental question asks why non-coding RNA partition into different spatial compartments. We report on the analysis of cellular compartment models with miRNA data sources for spatial-mechanistic modeling to address the broad area of multi-scalar cellular communication by miRNAs. We show that spatial partitioning of miRNAs is related to sequence similarity to the overall transcriptome. This has broad implications in biological informatics for gene regulation and provides a deeper understanding of nucleotide sequence structure and RNA language meaning for human pathologies resulting from changes in gene expression.
authors.affiliation: Physiology Department, Morehouse School of Medicine, Atlanta, GA 30310, USA. wseffens@msm.edu.
authors.forename: William
authors.initials: W
authors.lastname: Seffens
authors.affiliation: Mathematics Department, Clark Atlanta University, Atlanta, GA 30314, USA. fabebe2014@gmail.com.
authors.forename: Fisseha
authors.initials: F
authors.lastname: Abebe
authors.affiliation: Physiology Department, Morehouse School of Medicine, Atlanta, GA 30310, USA. crevans@msm.edu.
authors.forename: Chad
authors.initials: C
authors.lastname: Evans
authors.affiliation: Physics Department, Clark Atlanta University, Atlanta, GA 30314, USA. xwang@cau.edu.
authors.forename: Xiao-Qian
authors.initials: XQ
authors.lastname: Wang
mesh_terms: D019295:Computational Biology / Q000379:methods; D030561:Databases, Nucleic Acid; D055354:Exosomes / Q000235:genetics; D020869:Gene Expression Profiling; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D035683:MicroRNAs / Q000737:chemistry / Q000235:genetics*; D008954:Models, Biological; D012689:Sequence Homology, Nucleic Acid; D059467:Transcriptome
chemical_list: D035683:MicroRNAs
keywords: exosome; miRNA; transcriptome