title: Type 2 diabetes mellitus as a risk factor for dementia in a Mexican population.
abstract: Type 2 diabetes mellitus (T2DM) and dementia increase with age. Different studies have explored their association, but the possible relationship between them is still unclear.
  
  
  
  This is an analysis of the 10/66 Dementia Research Group (DRG) Mexico database; the sample comprised 1193 subjects ≥65 years old followed-up for three years. We calculated the incidence of dementia in subjects with diabetes using three models of analysis.
  
  
  
  T2DM patients have nearly twice the risk of developing dementia (RR 1.9; 95% CI 1.3-2.6) after three years of follow-up. The incidence of dementia is higher in subjects with undiagnosed diabetes. Higher serum glucose levels have a stronger association with dementia.
  
  
  
  It is important to implement early evaluation and monitoring cognitive performance in elders with diabetes to identify minor cognitive impairment and undertake timely interventions to prevent or delay the onset of dementia.
authors.affiliation: Laboratory of Dementias, National Institute of Neurology and Neurosurgery, Autonomous National University of Mexico, Insurgentes sur 3877, Colonia La Fama, 14269, Mexico City, Mexico.
authors.forename: Rosa María
authors.initials: RM
authors.lastname: Salinas
authors.affiliation: Department of Neurodevelopmental and Physiology, Neuroscience Division, Institute of Cellular Physiology, Autonomous National University of Mexico, Ciudad Universitaria, Circuito Ext. Coyoacan, 04510, Mexico City, Mexico.
authors.forename: Marcia
authors.initials: M
authors.lastname: Hiriart
authors.affiliation: Laboratory of Dementias, National Institute of Neurology and Neurosurgery, Autonomous National University of Mexico, Insurgentes sur 3877, Colonia La Fama, 14269, Mexico City, Mexico.
authors.forename: Isaac
authors.initials: I
authors.lastname: Acosta
authors.affiliation: Laboratory of Dementias, National Institute of Neurology and Neurosurgery, Autonomous National University of Mexico, Insurgentes sur 3877, Colonia La Fama, 14269, Mexico City, Mexico. Electronic address: drasosa@hotmail.com.
authors.forename: Ana Luisa
authors.initials: AL
authors.lastname: Sosa
authors.affiliation: Department of Health Service and Population Research, P060 Institute of Psychiatry, De Crespigny park, London SE5 8AF UK.
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Prince
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003704:Dementia / Q000453:epidemiology / Q000209:etiology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008800:Mexico / Q000453:epidemiology; D012307:Risk Factors
keywords: Chronic diseases; Dementia; Elders; Risk factors; Type 2 diabetes mellitus