title: Altered intrinsic regional brain spontaneous activity in patients with comitant strabismus: a resting-state functional MRI study.
abstract: OBJECTIVE
  To investigate the underlying regional homogeneity (ReHo) of brain-activity abnormalities in patients with comitant strabismus (CS) and their relationship with behavioral performance.
  
  
  METHODS
  Twenty patients with CS (ten men and ten women) and 20 (ten men and ten women) age-, sex-, and education-matched healthy controls (HCs) underwent resting-state functional magnetic resonance imaging scans. The ReHo method was used to assess local features of spontaneous brain activities. Patients with CS were distinguished from HCs by receiver operating characteristic curve. Correlation analysis was performed to explore the relationship between the observed mean ReHo values of the different brain areas and behavioral performance.
  
  
  RESULTS
  Compared to HCs, the patients with CS showed significantly increased ReHo values in the right inferior temporal cortex/fusiform gyrus/cerebellum anterior lobe, right lingual gyrus, and bilateral cingulate gyrus. We did not find any relationship between the observed mean ReHo values of the different brain areas and behavioral performance.
  
  
  CONCLUSIONS
  CS causes dysfunction in many brain regions, which may explain the fusion compensation in CS.
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute and Oculopathy Research Centre, Nanchang, People's Republic of China; Department of Ophthalmology, The First People's Hospital of Jiujiang City, Jiujiang, People's Republic of China.
authors.forename: Xin
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Medical Imaging Research Institute, Nanchang, Jiangxi, People's Republic of China.
authors.forename: Sheng-Hong
authors.initials: SH
authors.lastname: Li
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Medical Imaging Research Institute, Nanchang, Jiangxi, People's Republic of China.
authors.forename: Fu-Qing
authors.initials: FQ
authors.lastname: Zhou
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute and Oculopathy Research Centre, Nanchang, People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute and Oculopathy Research Centre, Nanchang, People's Republic of China.
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Zhong
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Medical Imaging Research Institute, Nanchang, Jiangxi, People's Republic of China.
authors.forename: Feng-Qin
authors.initials: FQ
authors.lastname: Cai
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute and Oculopathy Research Centre, Nanchang, People's Republic of China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Shao
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Medical Imaging Research Institute, Nanchang, Jiangxi, People's Republic of China.
authors.forename: Xian-Jun
authors.initials: XJ
authors.lastname: Zeng
keywords: comitant strabismus; functional magnetic resonance imaging; regional homogeneity; resting state