title: Effect of the antiepileptic therapy on olfactory disorders associated with mesial temporal sclerosis.
abstract: Parosmia has been described in neurological disorders, including temporal epilepsy. We reported a case of parosmia associated with unilateral hyposmia and mesial temporal sclerosis. We assessed the olfactory function by using Sniffin' sticks test and olfactory event-related potentials (OERPs). The findings of unilateral deficit of identification associated with parosmia only in the side ipsilateral to mesial temporal sclerosis area, that involves temporal olfactory regions responsible for higher level of smell processing, suggest a central genesis of olfactory disorders. The administration of levetiracetam restored olfactory function, OERP N1-P2 amplitude, and mesial temporal sclerosis-related electroencephalographic findings.
authors.affiliation: a IRCCS Centro Neurolesi "Bonino-Pulejo" , Messina , Italy.
authors.forename: Fabrizia
authors.initials: F
authors.lastname: Caminiti
authors.affiliation: a IRCCS Centro Neurolesi "Bonino-Pulejo" , Messina , Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: De Salvo
authors.affiliation: a IRCCS Centro Neurolesi "Bonino-Pulejo" , Messina , Italy.
authors.forename: Domenica
authors.initials: D
authors.lastname: Nunnari
authors.affiliation: a IRCCS Centro Neurolesi "Bonino-Pulejo" , Messina , Italy.
authors.forename: Placido
authors.initials: P
authors.lastname: Bramanti
authors.affiliation: a IRCCS Centro Neurolesi "Bonino-Pulejo" , Messina , Italy.
authors.forename: Rosella
authors.initials: R
authors.lastname: Ciurleo
authors.affiliation: b Department of Biomedical Sciences and Morphological and Functional Imaging , University of Messina , Messina , Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Granata
authors.affiliation: a IRCCS Centro Neurolesi "Bonino-Pulejo" , Messina , Italy.|b Department of Biomedical Sciences and Morphological and Functional Imaging , University of Messina , Messina , Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Marino
mesh_terms: D000927:Anticonvulsants / Q000008:administration & dosage / Q000494:pharmacology*; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006624:Hippocampus / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D000077287:Levetiracetam; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D000857:Olfaction Disorders / Q000188:drug therapy* / Q000503:physiopathology*; D010889:Piracetam / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D012598:Sclerosis / Q000473:pathology; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000473:pathology*
chemical_list: D000927:Anticonvulsants; D000077287:Levetiracetam; D010889:Piracetam
keywords: Levetiracetam; OERPs; mesial sclerosis; parosmia