title: Maternal outcomes and follow-up of preterm and term neonates born to mothers with systemic lupus erythematosus.
abstract: OBJECTIVE
  There is little follow-up data in preterm infants from mothers with systemic lupus erythematosus (SLE). The aim of this study was to determine maternal outcomes and compare neonatal outcomes in preterm and term infants born to mothers with SLE.
  
  
  METHODS
  This study is a prospective study in a tertiary medical care center and clinical research center for rheumatoid arthritis. Demographic data, clinical features, laboratory findings, treatment and complications in 77 pregnant SLE patients were prospectively evaluated from 2007 to 2013.
  
  
  RESULTS
  Ninety-two infants (44 males and 48 females including four sets of twins) from 77 mothers with SLE were enrolled. Multivariate logistic analysis indicated that flares were significantly associated with antiphospholipid antibodies of lupus anticoagulant during pregnancy (p = 0.009) and preterm birth (p = 0.017). Compared with term infants, preterm infants had significantly higher antinuclear antibodies (ANA) positivity (p = 0.001) at 12 months of age in multivariate logistic analysis.
  
  
  CONCLUSIONS
  Preterm birth is associated with maternal flares and persistent ANA positivity at 12 months of life in infants born to mothers with SLE.
authors.affiliation: a Department of Pediatrics , Hanyang University Hospital for Rheumatic Diseases Clinical Research Center for Rheumatoid Arthritis , Seoul , Republic of Korea.
authors.forename: Jae-Kyoon
authors.initials: JK
authors.lastname: Hwang
authors.affiliation: a Department of Pediatrics , Hanyang University Hospital for Rheumatic Diseases Clinical Research Center for Rheumatoid Arthritis , Seoul , Republic of Korea.
authors.forename: Hyun-Kyung
authors.initials: HK
authors.lastname: Park
authors.affiliation: b Department of Rheumatology.
authors.forename: Yoon-Kyoung
authors.initials: YK
authors.lastname: Sung
authors.affiliation: c Department of Obstetrics and Gynecology , Hanyang University College of Medicine , Seoul , Republic of Korea.
authors.forename: Jeong-Kyu
authors.initials: JK
authors.lastname: Hoh
authors.affiliation: a Department of Pediatrics , Hanyang University Hospital for Rheumatic Diseases Clinical Research Center for Rheumatoid Arthritis , Seoul , Republic of Korea.
authors.forename: Hyun Ju
authors.initials: HJ
authors.lastname: Lee
mesh_terms: D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D016682:Lupus Coagulation Inhibitor / Q000097:blood*; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000150:complications* / Q000276:immunology; D008297:Male; D011247:Pregnancy; D047928:Premature Birth / Q000097:blood / Q000276:immunology*; D011446:Prospective Studies; D000067251:Symptom Flare Up
chemical_list: D000974:Antibodies, Antinuclear; D016682:Lupus Coagulation Inhibitor
keywords: Antinuclear antibody; follow-up; lupus flare; lupus pregnancy; premature infants