title: Outcome benefit of abdominal paracentesis drainage for severe acute pancreatitis patients with serum triglyceride elevation by decreasing serum lipid metabolites.
abstract: BACKGROUND
  Our previous reports demonstrated that abdominal paracentesis drainage (APD) exerts a beneficial effect on severe acute pancreatitis (SAP) patients. However, the underlying mechanisms for this effectiveness are not well understood.
  
  
  METHODS
  A retrospective cohort of 132 consecutive non-hypertriglyceridemia (HTG)-induced SAP patients with triglyceride (TG) elevation and pancreatitis-associated ascitic fluid (PAAF) was recruited from May 2010 to May 2015 and included in this study. The patients were divided into two groups: the APD group (n = 68) and the non-APD group (n = 64). The monitored parameters mainly included mortality, hospital stay, the incidence of further intervention, levels of serum lipid metabolites and inflammatory factors, parameters related to organ failure and infections, and severity scores.
  
  
  RESULTS
  The demographic data and severity scores were comparable between the two groups. Compared with the non-APD group, the primary outcomes (including mortality, hospital stay and the incidence of percutaneous catheter drainage) in the APD group were improved. The serum levels of lipid metabolites were significantly lower in the APD group after 2 weeks of treatment than in the non-APD group. Logistic regression analysis indicated that the decreased extent of free fatty acid (FFA)(odds ratio, 1.435; P = 0.015) was a predictor of clinical improvement after 2 weeks of treatment.
  
  
  CONCLUSIONS
  Treatment with APD benefits non-HTG-induced SAP patients with serum TG elevation by decreasing serum levels of FFA.
authors.affiliation: Postgraduate Department, Third Military Medical University, Chongqing, China.|General Surgery Center of PLA, Chengdu Military General Hospital, Chengdu, Sichuan Province, 610083, China.
authors.forename: Zhu
authors.initials: Z
authors.lastname: Huang
authors.affiliation: General Surgery Center of PLA, Chengdu Military General Hospital, Chengdu, Sichuan Province, 610083, China.
authors.forename: Sun-Hong
authors.initials: SH
authors.lastname: Yu
authors.affiliation: General Surgery Center of PLA, Chengdu Military General Hospital, Chengdu, Sichuan Province, 610083, China.
authors.forename: Hong-Yin
authors.initials: HY
authors.lastname: Liang
authors.affiliation: Postgraduate Department, Third Military Medical University, Chongqing, China.|General Surgery Center of PLA, Chengdu Military General Hospital, Chengdu, Sichuan Province, 610083, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhou
authors.affiliation: General Surgery Center of PLA, Chengdu Military General Hospital, Chengdu, Sichuan Province, 610083, China.
authors.forename: Hong-Tao
authors.initials: HT
authors.lastname: Yan
authors.affiliation: General Surgery Center of PLA, Chengdu Military General Hospital, Chengdu, Sichuan Province, 610083, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Chen
authors.affiliation: General Surgery Center of PLA, Chengdu Military General Hospital, Chengdu, Sichuan Province, 610083, China.
authors.forename: Long
authors.initials: L
authors.lastname: Cheng
authors.affiliation: General Surgery Center of PLA, Chengdu Military General Hospital, Chengdu, Sichuan Province, 610083, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Ning
authors.affiliation: General Surgery Center of PLA, Chengdu Military General Hospital, Chengdu, Sichuan Province, 610083, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.affiliation: General Surgery Center of PLA, Chengdu Military General Hospital, Chengdu, Sichuan Province, 610083, China.
authors.forename: Zhu-Lin
authors.initials: ZL
authors.lastname: Luo
authors.affiliation: General Surgery Center of PLA, Chengdu Military General Hospital, Chengdu, Sichuan Province, 610083, China.
authors.forename: Kui-Ying
authors.initials: KY
authors.lastname: Wang
authors.affiliation: General Surgery Center of PLA, Chengdu Military General Hospital, Chengdu, Sichuan Province, 610083, China. 76119469@qq.com.
authors.forename: Wei-Hui
authors.initials: WH
authors.lastname: Liu
authors.affiliation: General Surgery Center of PLA, Chengdu Military General Hospital, Chengdu, Sichuan Province, 610083, China. 63135482@qq.com.
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Tang
mesh_terms: D000005:Abdomen / Q000601:surgery; D000208:Acute Disease; D000328:Adult; D001202:Ascitic Fluid / Q000737:chemistry; D004322:Drainage; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data; D016015:Logistic Models; D008875:Middle Aged; D016017:Odds Ratio; D010195:Pancreatitis / Q000097:blood* / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D019152:Paracentesis; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016019:Survival Analysis; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood*
chemical_list: D005230:Fatty Acids, Nonesterified; D014280:Triglycerides
keywords: Abdominal paracentesis drainage; Free fatty acid; Severe acute pancreatitis