title: Effect of Nigella sativa L. seed extract on cisplatin-induced delay in gastric emptying in Sprague-Dawley rats.
abstract: The aim of this study was focused on investigating the possible protective effect of Nigella sativa L. seed extract against cisplatin-induced delay in gastric emptying, in a rat model. Twenty-five male Sprague-Dawley rats were divided into five equal groups as follows: Group I or control group, Group II (cisplatin 10 mg/kg, i.p at day 5), Group III (N. sativa L. 250 mg/kg for 5 days + cisplatin 10 mg/kg, i.p on day 5), Group IV (N. sativa L. 500 mg/kg for 5 days + cisplatin 10 mg/kg, i.p on day 5) and Group V (ondansetron 3 mg/kg/day, per os + cisplatin 10 mg/kg, i.p on day 5). Phenol red meal was adopted to estimate gastric emptying in different groups of the rats. Gastric emptying was significantly increased (p < 0.01) in N. sativa L. seed extract-pretreated rats (Group III and Group IV) when compared to cisplatin treatment alone (Group II). However, ondansetron produced significantly (p < 0.01) better reversal than N. sativa L. seed extract.
authors.affiliation: a Faculty of Pharmacy , Integral University , Lucknow , India.
authors.forename: Ambreena
authors.initials: A
authors.lastname: Riyaz
authors.affiliation: b School of Veterinary Medicine , Wollo University , Dessie , Ethiopia.
authors.forename: Shahid
authors.initials: S
authors.lastname: Nazir
authors.affiliation: a Faculty of Pharmacy , Integral University , Lucknow , India.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Khushtar
authors.affiliation: a Faculty of Pharmacy , Integral University , Lucknow , India.
authors.forename: Anuradha
authors.initials: A
authors.lastname: Mishra
authors.affiliation: a Faculty of Pharmacy , Integral University , Lucknow , India.
authors.forename: Yasmeen
authors.initials: Y
authors.lastname: Jahan
authors.affiliation: a Faculty of Pharmacy , Integral University , Lucknow , India.
authors.forename: Asad
authors.initials: A
authors.lastname: Ahmad
mesh_terms: D000818:Animals; D002945:Cisplatin / Q000494:pharmacology*; D005746:Gastric Emptying / Q000187:drug effects*; D008297:Male; D031881:Nigella sativa; D017294:Ondansetron / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012639:Seeds
chemical_list: D010936:Plant Extracts; D017294:Ondansetron; D002945:Cisplatin
keywords: Nigella sativa L; cisplatin; gastric emptying; ondansetron