title: A Critical Overview on the Pharmacological and Clinical Aspects of Popular Satureja Species.
abstract: Throughout the world, various parts of most Satureja species are traditionally used to treat patients with various diseases and complications. As for the presence of different classes of metabolites in Satureja and their numerous ethnomedical and ethnopharmacological applications, many species have been pharmacologically evaluated. The current work aimed to compile information from pharmacological studies on this savory for further investigations. The keyword Satureja was searched through Scopus and PubMed up to January 1, 2016. We found nearly 55 papers that dealt with the pharmacology of Satureja. We found that 13 species had been evaluated pharmacologically and that Satureja khuzestanica, Satureja bachtiarica, Satureja montana and Satureja hortensis appeared to be the most active, both clinically and phytopharmacologically. Regarding the content of rich essential oil, most evaluations were concerned with the antimicrobial properties. However, the antioxidant, antidiabetic and anticholesterolemic properties of the studied species were found to be good. In addition to the pharmacological activities that have been indentified for some species, opportunities still exist to assess the effectiveness of other well-known species. If different Satureja species are to have extensive ethnopharmacological applications, comprehensive assessments of the acute and chronic toxicities, as well as the teratogenicity, of those plants are needed.
authors.affiliation: Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Fereshteh
authors.initials: F
authors.lastname: Jafari
authors.affiliation: Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Ghavidel
authors.affiliation: Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: zarm@sums.ac.ir.
authors.forename: Mohammad M
authors.initials: MM
authors.lastname: Zarshenas
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D031362:Satureja / Q000737:chemistry* / Q000145:classification
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D007004:Hypoglycemic Agents; D010936:Plant Extracts
keywords: Satureja; ethnopharmacology; plant extracts