title: PEGylated polyethylenimine-entrapped gold nanoparticles loaded with gadolinium for dual-mode CT/MR imaging applications.
abstract: To synthesize and characterize cost-efficient polyethylenimine-entrapped gold nanoparticles loaded with gadolinium (Gd@Au PENPs) for dual-mode computed tomography (CT)/magnetic resonance (MR) imaging applications.
  
  
  
  PEGylated PEI modified with gadolinium (Gd) chelator (DOTA) was used as a template to synthesize the Gd@Au PENPs and the particles were well characterized in terms of their physicochemical properties, cytotoxicity and performances in CT and MR imaging in vitro and in vivo.
  
  
  
  The formed Gd@Au PENPs with low cytotoxicity can be used as a highly efficient contrast agent for dual-mode CT/MR imaging of blood pool and major organs of animals.
  
  
  
  The designed Gd@Au PENPs may be used as a versatile nanoplatform for dual-mode CT/MR imaging of different biological systems.
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers & Polymer Materials, College of Chemistry, Chemical Engineering & Biotechnology, Donghua University, Shanghai 201620, People's Republic of China.
authors.forename: Benqing
authors.initials: B
authors.lastname: Zhou
authors.affiliation: Department of Radiology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, People's Republic of China.
authors.forename: Zuogang
authors.initials: Z
authors.lastname: Xiong
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers & Polymer Materials, College of Chemistry, Chemical Engineering & Biotechnology, Donghua University, Shanghai 201620, People's Republic of China.
authors.forename: Jianzhi
authors.initials: J
authors.lastname: Zhu
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers & Polymer Materials, College of Chemistry, Chemical Engineering & Biotechnology, Donghua University, Shanghai 201620, People's Republic of China.
authors.forename: Mingwu
authors.initials: M
authors.lastname: Shen
authors.affiliation: Department of Radiology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, People's Republic of China.
authors.forename: Guangyu
authors.initials: G
authors.lastname: Tang
authors.affiliation: Department of Radiology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, People's Republic of China.
authors.forename: Chen
authors.initials: C
authors.lastname: Peng
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers & Polymer Materials, College of Chemistry, Chemical Engineering & Biotechnology, Donghua University, Shanghai 201620, People's Republic of China.
authors.forename: Xiangyang
authors.initials: X
authors.lastname: Shi
mesh_terms: D000818:Animals; D002470:Cell Survival; D003287:Contrast Media / Q000737:chemistry* / Q000633:toxicity; D005682:Gadolinium / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D006801:Humans; D007624:KB Cells; D008279:Magnetic Resonance Imaging; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D051379:Mice; D061848:Optical Imaging; D011092:Polyethylene Glycols / Q000737:chemistry*; D011094:Polyethyleneimine / Q000737:chemistry*; D013499:Surface Properties; D014018:Tissue Distribution; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D011092:Polyethylene Glycols; D006046:Gold; D011094:Polyethyleneimine; D005682:Gadolinium
keywords: CT imaging; MR imaging; T1 MR relaxometry; gadolinium; gold nanoparticles; polyethylene glycol; polyethylenimine; x-ray attenuation property