title: Recognition and Assessment of Eosinophilic Esophagitis: The Development of New Clinical Outcome Metrics.
abstract: Eosinophilic esophagitis (EoE) is a chronic, food-allergic disease manifest by symptoms of esophageal dysfunction and dense esophageal eosinophilia in which other causes have been excluded. Treatments include dietary restriction of the offending allergens, topical corticosteroids, and dilation of strictures. EoE has become increasingly prevalent over the past decade and has been increasingly recognized as a major health concern. Advancements in research and clinical needs have led to the development of novel pediatric- and adult-specific clinical outcome metrics (COMs). These COMs provide ways to measure clinically relevant features in EoE and set the stage for measuring outcomes in future therapeutic trials. In this article, we review novel symptom measurement assessments, the use of radiographic imaging to serve as a metric for therapeutic interventions, recently developed standardized methods for endoscopic assessment, novel techniques to evaluate esophageal mucosal inflammation, and methods for functional assessment of the esophagus. These advancements, in conjunction with current consensus recommendations, will improve the clinical assessment of patients with EoE.
authors.affiliation: Dr Nguyen is a pediatric gastroenterology and hepatology fellow, Dr Furuta is a professor of pediatrics, and Dr Menard-Katcher is an assistant professor of pediatrics at the Digestive Health Institute and the Section of Pediatric Gastroenterology, Hepatology and Nutrition at Children's Hospital Colorado in Aurora, Colorado. The authors are also affiliated with the Gastrointestinal Eosinophilic Diseases Program and the Mucosal Inflammation Program at the University of Colorado School of Medicine in Aurora, Colorado.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Nguyen
authors.affiliation: Dr Nguyen is a pediatric gastroenterology and hepatology fellow, Dr Furuta is a professor of pediatrics, and Dr Menard-Katcher is an assistant professor of pediatrics at the Digestive Health Institute and the Section of Pediatric Gastroenterology, Hepatology and Nutrition at Children's Hospital Colorado in Aurora, Colorado. The authors are also affiliated with the Gastrointestinal Eosinophilic Diseases Program and the Mucosal Inflammation Program at the University of Colorado School of Medicine in Aurora, Colorado.
authors.forename: Glenn T
authors.initials: GT
authors.lastname: Furuta
authors.affiliation: Dr Nguyen is a pediatric gastroenterology and hepatology fellow, Dr Furuta is a professor of pediatrics, and Dr Menard-Katcher is an assistant professor of pediatrics at the Digestive Health Institute and the Section of Pediatric Gastroenterology, Hepatology and Nutrition at Children's Hospital Colorado in Aurora, Colorado. The authors are also affiliated with the Gastrointestinal Eosinophilic Diseases Program and the Mucosal Inflammation Program at the University of Colorado School of Medicine in Aurora, Colorado.
authors.forename: Calies
authors.initials: C
authors.lastname: Menard-Katcher
keywords: Eosinophil; clinical outcome metrics; eosinophilic esophagitis; eosinophilic gastrointestinal disease