title: Quantitative assessment technique of HyperEye medical system angiography for coronary artery bypass grafting.
abstract: OBJECTIVE
  The HyperEye Medical System (HEMS) uses indocyanine green (ICG) to visualize blood vessels in coronary artery bypass grafting (CABG). We performed quantitative HEMS assessment to detect grafts at risk of occlusion.
  
  
  METHODS
  We assessed the HEMS angiograms of 177 grafts from 69 patients who underwent CABG and compared the results with those of fluoroscopic coronary angiography, by measuring the increasing rate of ICG intensity, average acceleration value, and time to peak luminance intensity.
  
  
  RESULTS
  Grafts in the patent and failed groups showed significant differences in their increasing rate of intensity and average acceleration value. The average accelerations value of ICG intensity of internal thoracic artery (ITA) and saphenous vein (SV) grafts were 112.3 and 144.9 intensity/s2in the patent group, and 71.0 and 91.8 intensity/s2in the failed group. The time to peak luminance intensity was 1.7 and 1.4 s in the patent group and 2.3 and 1.9 s in the failed group; these values were not significantly different.
  
  
  CONCLUSIONS
  Significant reductions in the ICG intensity rate and average acceleration value can occur in failed grafts. Therefore, quantifiable changes in ICG intensity may help detect minute changes in blood flow.
authors.affiliation: Departments of Surgery II and Cardiovascular Control, Kochi Medical School, Kohasu, Oko-cho, Nankoku-shi, Kochi, 783-8505, Japan. y-masaki@kochi-u.ac.jp.
authors.forename: Masaki
authors.initials: M
authors.lastname: Yamamoto
authors.affiliation: Departments of Surgery II and Cardiovascular Control, Kochi Medical School, Kohasu, Oko-cho, Nankoku-shi, Kochi, 783-8505, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Nishimori
authors.affiliation: Departments of Surgery II and Cardiovascular Control, Kochi Medical School, Kohasu, Oko-cho, Nankoku-shi, Kochi, 783-8505, Japan.
authors.forename: Takemi
authors.initials: T
authors.lastname: Handa
authors.affiliation: Departments of Surgery II and Cardiovascular Control, Kochi Medical School, Kohasu, Oko-cho, Nankoku-shi, Kochi, 783-8505, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Fukutomi
authors.affiliation: Departments of Surgery II and Cardiovascular Control, Kochi Medical School, Kohasu, Oko-cho, Nankoku-shi, Kochi, 783-8505, Japan.
authors.forename: Kazuki
authors.initials: K
authors.lastname: Kihara
authors.affiliation: Departments of Surgery II and Cardiovascular Control, Kochi Medical School, Kohasu, Oko-cho, Nankoku-shi, Kochi, 783-8505, Japan.
authors.forename: Miwa
authors.initials: M
authors.lastname: Tashiro
authors.affiliation: Departments of Surgery II and Cardiovascular Control, Kochi Medical School, Kohasu, Oko-cho, Nankoku-shi, Kochi, 783-8505, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Sato
authors.affiliation: Departments of Surgery II and Cardiovascular Control, Kochi Medical School, Kohasu, Oko-cho, Nankoku-shi, Kochi, 783-8505, Japan.
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Orihashi
mesh_terms: D000368:Aged; D000792:Angiography / Q000379:methods*; D001783:Blood Flow Velocity; D001026:Coronary Artery Bypass; D005260:Female; D006083:Graft Occlusion, Vascular / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000517:prevention & control*; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D008323:Mammary Arteries / Q000000981:diagnostic imaging*; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods*; D012189:Retrospective Studies; D012306:Risk; D012501:Saphenous Vein / Q000000981:diagnostic imaging*; D014654:Vascular Patency
chemical_list: D007208:Indocyanine Green
keywords: Coronary artery bypass grafting; HyperEye medical System; Indocyanine green angiography; Quantitative assessment technique