title: Primary Cutaneous B-Cell Lymphoma in Young Monozygotic Twins: A Case Report.
abstract: Although familial aggregation of lymphoproliferative disorders has been described, heredity has not been implicated in the etiology of primary cutaneous B-cell lymphomas (PCBCL). We report herein the first case of 2 young monozygotic twins with PCBCL. The first twin was an 18-year-old woman when she presented with multiple skin nodules on the thorax and head. Histology showed an atypical small B-cell proliferation, consistent with primary cutaneous marginal zone lymphoma (PCMZL). Molecular genetics studies demonstrated B-cell clonality. Seven years later, the second twin developed her first lesion that was histologically similar to that of her twin. She subsequently developed other clinically similar lesions. Histology was consistent with PCMZL and showed B-cell clonality. Occurrence of PCBCL in these monozygotic twins raises the possibility of a genetic risk factor. Further study of such rare cases may offer valuable insights into the molecular basis of the etiology and pathogenesis of this unusual disorder.
authors.affiliation: Department of Radiation Oncology, Centre Hospitalier de l'Université de Montréal (CHUM), Montréal, QC, Canada.
authors.forename: Houda
authors.initials: H
authors.lastname: Bahig
authors.affiliation: Jewish General Hospital, McGill University, Montréal, QC, Canada.|McGill Multidisciplinary Cutaneous Lymphoma Clinic, Montréal, QC, Canada.
authors.forename: Tina
authors.initials: T
authors.lastname: Petrogiannis-Haliotis
authors.affiliation: Jewish General Hospital, McGill University, Montréal, QC, Canada.|McGill Multidisciplinary Cutaneous Lymphoma Clinic, Montréal, QC, Canada.
authors.forename: Kevin L
authors.initials: KL
authors.lastname: Pehr
authors.affiliation: Department of Radiation Oncology, Centre Hospitalier de l'Université de Montréal (CHUM), Montréal, QC, Canada david.roberge.chum@ssss.gouv.qc.ca.|McGill Multidisciplinary Cutaneous Lymphoma Clinic, Montréal, QC, Canada.
authors.forename: David
authors.initials: D
authors.lastname: Roberge
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000235:genetics* / Q000473:pathology*; D012878:Skin Neoplasms / Q000235:genetics* / Q000473:pathology*; D014430:Twins, Monozygotic
keywords: cancer; dermatology; pathology