title: A systematic review on human exposure to organophosphorus pesticides in Iran.
abstract: Human exposure to organophosphorus (OP) pesticides is a serious health challenge. We conducted a systematic review by searching international and national databases for published literature on any human exposure to OPs in Iran from 1990 to March 2015. Qualified papers were in two categories including studies in which biomarkers of exposure were assessed (n = 13; total no. of subjects = 759) and studies that had reported prevalence of OPs-induced poisoning (OPP) and mortality (n = 26; total no. of subjects = 5428). The mean level of activity of acetyl-cholinesterase and butyryl-cholinesterase were 68.65% and 74.2%, respectively. Overall proportion (%) of OPP was estimated (16; 95% CI, 14 to 19).
authors.affiliation: a Department of Toxicology and Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences Research Center , Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Amir
authors.initials: A
authors.lastname: Shadboorestan
authors.affiliation: b Research Center for Modeling in Health, Institute for Futures Studies in Health, Kerman University of Medical Sciences , Kerman , Iran.
authors.forename: Hossein Molavi
authors.initials: HM
authors.lastname: Vardanjani
authors.affiliation: a Department of Toxicology and Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences Research Center , Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Abdollahi
authors.affiliation: a Department of Toxicology and Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences Research Center , Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Mohammad Hadi
authors.initials: MH
authors.lastname: Goharbari
authors.affiliation: c Environmental Health Engineering Research Center, Kerman University of Medical Sciences , Kerman , Iran.
authors.forename: Narges
authors.initials: N
authors.lastname: Khanjani
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D004781:Environmental Exposure / Q000706:statistics & numerical data*; D004785:Environmental Pollutants / Q000032:analysis*; D004787:Environmental Pollution / Q000706:statistics & numerical data*; D006801:Humans; D007492:Iran; D009943:Organophosphorus Compounds / Q000032:analysis*; D010575:Pesticides / Q000032:analysis*
chemical_list: D015415:Biomarkers; D004785:Environmental Pollutants; D009943:Organophosphorus Compounds; D010575:Pesticides; D000110:Acetylcholinesterase
keywords: Iran; Systematic review; mortality; organophosphorus; poisoning prevalence