title: Pathogen Inhibition by Multivalent Ligand Architectures.
abstract: Interfacial multivalent interactions at pathogen-cell interfaces can be competitively inhibited by multivalent scaffolds that prevent pathogen adhesion to the cells during the initial stages of infection. The lack of understanding of complex biological systems makes the design of an efficient multivalent inhibitor a toilsome task. Therefore, we have highlighted the main issues and concerns associated with blocking pathogen at interfaces, which are dependent on the nature and properties of both multivalent inhibitors and pathogens, such as viruses and bacteria. The challenges associated with different cores or carrier scaffolds of multivalent inhibitors are concisely discussed with selected examples.
authors.affiliation: Institut für Chemie und Biochemie, Freie Universität Berlin , Takustrasse 3, 14195 Berlin, Germany.
authors.forename: Sumati
authors.initials: S
authors.lastname: Bhatia
authors.affiliation: Institut für Chemie und Biochemie, Freie Universität Berlin , Takustrasse 3, 14195 Berlin, Germany.
authors.forename: Luis Cuellar
authors.initials: LC
authors.lastname: Camacho
authors.affiliation: Institut für Chemie und Biochemie, Freie Universität Berlin , Takustrasse 3, 14195 Berlin, Germany.
authors.forename: Rainer
authors.initials: R
authors.lastname: Haag
mesh_terms: D001696:Biomechanical Phenomena; D002448:Cell Adhesion / Q000187:drug effects; D055808:Drug Discovery / Q000379:methods*; D054884:Host-Pathogen Interactions; D008024:Ligands
chemical_list: D008024:Ligands