title: Iodine-131 in Helicobacter pylori-positive patients: preliminary accidental finding and in differentiated thyroid cancer.
abstract: OBJECTIVE
  To investigate the eradicate effect of Helicobacter pylori in differentiated thyroid cancer patients who underwent I therapy.
  
  
  METHODS
  A total of 130 patients with differentiated thyroid cancer underwent I treatment. None of the patients had a history of stomach-related diseases. The C-urea breath test (UBT) was carried out for H. pylori examination before I treatment. The cut-off value for C-UBT was 4%. For H. pylori test-positive patients, a second C-UBT was performed 4-6 weeks after I treatment. T-tests were used to compare the difference before and 4-6 weeks after I treatment.
  
  
  RESULTS
  A total of 42 of 130 (32.31%) patients were H. pylori positive. The average value of H. pylori was 28.36% before I, whereas the value was 18.18% after I therapy. A significant decrease in C-UBT was found after I treatment compared with before therapy (P<0.01).
  
  
  CONCLUSIONS
  Our preliminary data showed that I exerts certain eradication effects on H. pylori, which could provide a new approach to multidrug resistance pathogens. As the exact molecular mechanism of this phenomenon is still unclear, future clinical applications of this anecdotal finding require further assessments.
authors.affiliation: aDepartment of Nuclear Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University bInstitute of Health Sciences, Shanghai Jiao Tong University School of Medicine (SJTUSM) & Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) cShanghai University of Medicine and Health Sciences, Shanghai, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Xu
authors.forename: Linling
authors.initials: L
authors.lastname: Tang
authors.forename: Hong
authors.initials: H
authors.lastname: Yuan
authors.forename: Jianjun
authors.initials: J
authors.lastname: Liu
authors.forename: Gang
authors.initials: G
authors.lastname: Huang
authors.forename: Shaoli
authors.initials: S
authors.lastname: Song
mesh_terms: D000328:Adult; D001944:Breath Tests; D002247:Carbon Isotopes; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D016481:Helicobacter Infections / Q000150:complications* / Q000175:diagnosis / Q000532:radiotherapy*; D016480:Helicobacter pylori / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D033162:Incidental Findings; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D013964:Thyroid Neoplasms / Q000150:complications* / Q000473:pathology / Q000532:radiotherapy*; D014508:Urea; D055815:Young Adult
chemical_list: D002247:Carbon Isotopes; D007457:Iodine Radioisotopes; D014508:Urea