title: Recent advances in the development of protein tyrosine phosphatase 1B inhibitors for Type 2 diabetes.
abstract: Diabetes mellitus is the most serious and prevalent metabolic disorders worldwide, complications of which can decrease significantly the quality of life and contribute to premature death. Resistance to insulin is a predominant pathophysiological factor of Type 2 diabetes (T2D). Protein tyrosine phosphatase 1B (PTP1B) is an important negative factor of insulin signal and a potent therapeutic target in T2D patients. This review highlights recent advances (2012-2015) in research related to the role of PTP1B in signal transduction processes implicated in pathophysiology of T2D, and novel PTP1B inhibitors with an emphasis on their chemical structures and modes of action.
authors.affiliation: School of Food & Biotechnology, Xihua University, Chengdu 610039, PR China.
authors.forename: Shan
authors.initials: S
authors.lastname: Qian
authors.affiliation: School of Food & Biotechnology, Xihua University, Chengdu 610039, PR China.
authors.forename: Man
authors.initials: M
authors.lastname: Zhang
authors.affiliation: School of Food & Biotechnology, Xihua University, Chengdu 610039, PR China.
authors.forename: Yanying
authors.initials: Y
authors.lastname: He
authors.affiliation: School of Food & Biotechnology, Xihua University, Chengdu 610039, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: School of Food & Biotechnology, Xihua University, Chengdu 610039, PR China.
authors.forename: Siyan
authors.initials: S
authors.lastname: Liu
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1
keywords: Type 2 diabetes; insulin resistance; protein tyrosine phosphatase 1B