title: Validation of selected analytical methods using accuracy profiles to assess the impact of a Tobacco Heating System on indoor air quality.
abstract: Studies in environmentally controlled rooms have been used over the years to assess the impact of environmental tobacco smoke on indoor air quality. As new tobacco products are developed, it is important to determine their impact on air quality when used indoors. Before such an assessment can take place it is essential that the analytical methods used to assess indoor air quality are validated and shown to be fit for their intended purpose. Consequently, for this assessment, an environmentally controlled room was built and seven analytical methods, representing eighteen analytes, were validated. The validations were carried out with smoking machines using a matrix-based approach applying the accuracy profile procedure. The performances of the methods were compared for all three matrices under investigation: background air samples, the environmental aerosol of Tobacco Heating System THS 2.2, a heat-not-burn tobacco product developed by Philip Morris International, and the environmental tobacco smoke of a cigarette. The environmental aerosol generated by the THS 2.2 device did not have any appreciable impact on the performances of the methods. The comparison between the background and THS 2.2 environmental aerosol samples generated by smoking machines showed that only five compounds were higher when THS 2.2 was used in the environmentally controlled room. Regarding environmental tobacco smoke from cigarettes, the yields of all analytes were clearly above those obtained with the other two air sample types.
authors.affiliation: Philip Morris International R&D, Philip Morris Products SA (part of Philip Morris International group of companies), Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Mottier
authors.affiliation: Philip Morris International R&D, Philip Morris Products SA (part of Philip Morris International group of companies), Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland.
authors.forename: Manuel
authors.initials: M
authors.lastname: Tharin
authors.affiliation: Philip Morris International R&D, Philip Morris Products SA (part of Philip Morris International group of companies), Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland.
authors.forename: Camille
authors.initials: C
authors.lastname: Cluse
authors.affiliation: Philip Morris International R&D, Philip Morris Products SA (part of Philip Morris International group of companies), Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland.
authors.forename: Jean-René
authors.initials: JR
authors.lastname: Crudo
authors.affiliation: Philip Morris International R&D, Philip Morris Products SA (part of Philip Morris International group of companies), Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland.
authors.forename: María Gómez
authors.initials: MG
authors.lastname: Lueso
authors.affiliation: Philip Morris International R&D, Philip Morris Products SA (part of Philip Morris International group of companies), Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland.
authors.forename: Catherine G
authors.initials: CG
authors.lastname: Goujon-Ginglinger
authors.affiliation: Philip Morris International R&D, Philip Morris Products SA (part of Philip Morris International group of companies), Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland.
authors.forename: Anne
authors.initials: A
authors.lastname: Jaquier
authors.affiliation: Philip Morris International R&D, Philip Morris Products SA (part of Philip Morris International group of companies), Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland. Electronic address: maya.mitova@pmi.com.
authors.forename: Maya I
authors.initials: MI
authors.lastname: Mitova
authors.affiliation: Philip Morris International R&D, Philip Morris Products SA (part of Philip Morris International group of companies), Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland.
authors.forename: Emmanuel G R
authors.initials: EGR
authors.lastname: Rouget
authors.affiliation: Philip Morris International R&D, Philip Morris Products SA (part of Philip Morris International group of companies), Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Schaller
authors.affiliation: Philip Morris International R&D, Philip Morris Products SA (part of Philip Morris International group of companies), Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Solioz
mesh_terms: D000393:Air Pollutants / Q000032:analysis; D016902:Air Pollution, Indoor / Q000032:analysis*; D006358:Hot Temperature; D009538:Nicotine / Q000032:analysis; D052638:Particulate Matter / Q000032:analysis; D011725:Pyridines / Q000032:analysis; D062789:Tobacco Products; D014028:Tobacco Smoke Pollution / Q000032:analysis*; D055549:Volatile Organic Compounds / Q000032:analysis
chemical_list: D000393:Air Pollutants; D052638:Particulate Matter; D011725:Pyridines; D014028:Tobacco Smoke Pollution; D055549:Volatile Organic Compounds; C507758:ethynylpyridine; D009538:Nicotine
keywords: Accuracy profile; Aerosol; Environmentally controlled room; Indoor air quality; Tobacco Heating System 2.2; Validation