title: Food combination based on a pre-hispanic Mexican diet decreases metabolic and cognitive abnormalities and gut microbiota dysbiosis caused by a sucrose-enriched high-fat diet in rats.
abstract: There is few information about the possible health effects of a food combination based on a pre-hispanic Mexican diet (PMD). This diet rich in fiber, polyphenols, a healthy ratio of omega 6/omega 3 fatty acids, and vegetable protein could improve carbohydrate and lipid metabolism, gut microbiota and cognitive function.
  
  
  
  We examined the effect of a PMD in a sucrose enriched high-fat model. The PMD contains corn, beans, tomato, nopal, chia and pumpkin seeds in dehydrated form. Following induction of obesity, rats were fed PMD. PMD consumption decreased glucose intolerance, body weight gain, serum and liver triglycerides and leptin. In addition, PMD decreased the size of the adipocytes, and increased the protein abundance of UCP-1, PPAR-α, PGC1-α and Tbx-1 in white adipose tissue. Finally, the PMD significant decreased hepatic levels of ROS, oxidized proteins and GSSG/GSH ratio and an increase in the relative abundance of Bifidobacteria and the improvement of cognitive function.
  
  
  
  Consumption of a PMD decreased the glucose intolerance and the biochemical abnormalities caused by the obesity by increasing the abundance of proteins involved in fatty acid oxidation, decreasing the oxidative stress and modifying the gut microbiota.
authors.affiliation: Departamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico.
authors.forename: Azalia
authors.initials: A
authors.lastname: Avila-Nava
authors.affiliation: Departamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico.
authors.forename: Lilia G
authors.initials: LG
authors.lastname: Noriega
authors.affiliation: Departamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico.
authors.forename: Armando R
authors.initials: AR
authors.lastname: Tovar
authors.affiliation: Departamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico.
authors.forename: Omar
authors.initials: O
authors.lastname: Granados
authors.affiliation: Departamento de Farmacología CINVESTAV-IPN, Mexico.
authors.forename: Claudia
authors.initials: C
authors.lastname: Perez-Cruz
authors.affiliation: Departamento de Biología, Facultad de Química, Universidad Nacional Autónoma de México, Mexico.
authors.forename: José
authors.initials: J
authors.lastname: Pedraza-Chaverri
authors.affiliation: Departamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico.
authors.forename: Nimbe
authors.initials: N
authors.lastname: Torres
mesh_terms: D052436:Adipose Tissue, White / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D000818:Animals; D000975:Antioxidants / Q000032:analysis; D003071:Cognition / Q000187:drug effects*; D004032:Diet; D059305:Diet, High-Fat / Q000009:adverse effects*; D005227:Fatty Acids / Q000032:analysis; D000069196:Gastrointestinal Microbiome / Q000187:drug effects*; D005786:Gene Expression Regulation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000502:physiology; D018551:Solanum lycopersicum; D008800:Mexico; D009765:Obesity / Q000178:diet therapy* / Q000378:metabolism / Q000382:microbiology; D018384:Oxidative Stress / Q000187:drug effects; D017207:Rats, Sprague-Dawley; D013395:Sucrose / Q000009:adverse effects; D003313:Zea mays
chemical_list: D000975:Antioxidants; D005227:Fatty Acids; D013395:Sucrose
keywords: Gut microbiota; Oxidative stress; Pre-hispanic Mexican diet; Sucrose-enriched high-fat diet