title: Pancreatic analogue solid pseudopapillary neoplasm arising in the paratesticular location. The first case report.
abstract: We describe the first pancreatic analogue of solid pseudopapillary neoplasm arising in paratesticular location. It was a tumor arising in 32-year-old man adhering closely to the testis. The tumor had several morphologic components. The greatest was represented by signet ring cells which gradually changed into solid, non-signet ring cell areas, often being mixed together. It also formed distinct trabeculae and pseudopapillae frequently adhering to cystic areas of the tumor. Immunohistochemically, the tumor had an identical profile to its pancreatic counterpart. The tumor cells reacted diffusely with S100 protein, β-catenin, cyclin D1, Fli-1, vimentin, CD10, galectin-3, and neuron-specific enolase and focally with synaptophysin. CD56 and E-cadherin reacted only in those parts of the tumor, which formed pseudopapillae. Cytokeratin antibody AE1-AE3 was strongly positive in the areas of trabecular formation of the tumor. The mutational analysis of exon 3 of the CTNNB1 gene confirmed mutation in this exon.
authors.affiliation: Department of Pathology, Charles University, Biomedical Center, Faculty of Medicine in Plzen and Charles University Hospital, Plzen, Czech Republic, 30460. Electronic address: michael.michal@medima.cz.
authors.forename: Michal
authors.initials: M
authors.lastname: Michal
authors.affiliation: Department of Pathology, University Hospital Centre, Zagreb, Croatia, 100000.
authors.forename: Stela
authors.initials: S
authors.lastname: Bulimbasic
authors.affiliation: Department of Pathology, University Hospital Centre, Zagreb, Croatia, 100000.
authors.forename: Marijana
authors.initials: M
authors.lastname: Coric
authors.affiliation: Biopticka Laborator s.r.o., Plzen, Czech Republic, 32600.
authors.forename: Monika
authors.initials: M
authors.lastname: Sedivcova
authors.affiliation: Department of Pathology, Charles University, Medical Faculty and Charles University Hospital, Plzen, Czech Republic, 30460.
authors.forename: Dmitry V
authors.initials: DV
authors.lastname: Kazakov
authors.affiliation: Department of Pathology, Charles University, Biomedical Center, Faculty of Medicine in Plzen and Charles University Hospital, Plzen, Czech Republic, 30460.
authors.forename: Michael
authors.initials: M
authors.lastname: Michal
authors.affiliation: Department of Pathology, Charles University, Medical Faculty and Charles University Hospital, Plzen, Czech Republic, 30460.
authors.forename: Ondrej
authors.initials: O
authors.lastname: Hes
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics; D001706:Biopsy; D018279:Carcinoma, Signet Ring Cell / Q000737:chemistry / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D004252:DNA Mutational Analysis; D020022:Genetic Predisposition to Disease; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009154:Mutation; D018193:Neoplasms, Complex and Mixed / Q000737:chemistry / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D010190:Pancreatic Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D010641:Phenotype; D013736:Testicular Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D051176:beta Catenin / Q000032:analysis / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; C495270:CTNNB1 protein, human; D051176:beta Catenin
keywords: CTNNB1 gene; Pancreatic analogue solid pseudopapillary neoplasm; Paratesticular; Paratestis; Solid pseudopapillary neoplasm; Testis