title: Distinct mutations at the same positions of STAT3 cause either loss or gain of function.
authors.affiliation: Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md; Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Md.
authors.forename: Prabha
authors.initials: P
authors.lastname: Chandrasekaran
authors.affiliation: Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
authors.forename: Ofer
authors.initials: O
authors.lastname: Zimmerman
authors.affiliation: Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
authors.forename: Michelle
authors.initials: M
authors.lastname: Paulson
authors.affiliation: Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
authors.forename: Elizabeth P
authors.initials: EP
authors.lastname: Sampaio
authors.affiliation: Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
authors.forename: Alexandra F
authors.initials: AF
authors.lastname: Freeman
authors.affiliation: Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
authors.forename: Kathryn J
authors.initials: KJ
authors.lastname: Sowerwine
authors.affiliation: Bioinformatics and Computational Biosciences Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
authors.forename: Darell
authors.initials: D
authors.lastname: Hurt
authors.affiliation: Department of Molecular Biomedicine, CINVESTAV-IPN, Mexico City, Mexico.
authors.forename: Julio C
authors.initials: JC
authors.lastname: Alcántara-Montiel
authors.affiliation: Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
authors.forename: Amy P
authors.initials: AP
authors.lastname: Hsu
authors.affiliation: Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md. Electronic address: smh@nih.gov.
authors.forename: Steven M
authors.initials: SM
authors.lastname: Holland
mesh_terms: D019943:Amino Acid Substitution; D000818:Animals; D019556:COS Cells; D002460:Cell Line; D002522:Chlorocebus aethiops; D000073659:Gain of Function Mutation; D006801:Humans; D007589:Job Syndrome / Q000235:genetics; D000073658:Loss of Function Mutation; D008232:Lymphoproliferative Disorders / Q000235:genetics; D008958:Models, Molecular; D050505:Mutant Proteins / Q000737:chemistry / Q000235:genetics; D011994:Recombinant Proteins / Q000737:chemistry / Q000235:genetics; D050796:STAT3 Transcription Factor / Q000737:chemistry / Q000235:genetics* / Q000276:immunology; D055672:Static Electricity; D018909:src Homology Domains / Q000235:genetics
chemical_list: D050505:Mutant Proteins; D011994:Recombinant Proteins; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human