title: Role of Receptor Tyrosine Kinase Signaling in Renal Fibrosis.
abstract: Renal fibrosis can be induced in different renal diseases, but ultimately progresses to end stage renal disease. Although the pathophysiologic process of renal fibrosis have not been fully elucidated, it is characterized by glomerulosclerosis and/or tubular interstitial fibrosis, and is believed to be caused by the proliferation of renal inherent cells, including glomerular epithelial cells, mesangial cells, and endothelial cells, along with defective kidney repair, renal interstitial fibroblasts activation, and extracellular matrix deposition. Receptor tyrosine kinases (RTKs) regulate a variety of cell physiological processes, including metabolism, growth, differentiation, and survival. Many studies from in vitro and animal models have provided evidence that RTKs play important roles in the pathogenic process of renal fibrosis. It is also showed that tyrosine kinases inhibitors (TKIs) have anti-fibrotic effects in basic research and clinical trials. In this review, we summarize the evidence for involvement of specific RTKs in renal fibrosis process and the employment of TKIs as a therapeutic approach for renal fibrosis.
authors.affiliation: Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China. liufeng0113@126.com.
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China. szhuang@lifespan.org.|Department of Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI 02903, USA. szhuang@lifespan.org.
authors.forename: Shougang
authors.initials: S
authors.lastname: Zhuang
mesh_terms: D000818:Animals; D005355:Fibrosis / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D007668:Kidney / Q000378:metabolism* / Q000473:pathology; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*; D051436:Renal Insufficiency, Chronic / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; D020794:Receptor Protein-Tyrosine Kinases
keywords: discoidin domain receptors; epidermal growth factor receptor; fibroblast growth factor receptor; growth arrest-specific gene; insulin-like growth factor receptor; platelet-derived growth factors receptor; receptor tyrosine kinases; renal fibrosis; tyrosine kinase inhibitors; vascular endothelial growth factors receptor