title: Methylprednisolone microsphere sustained-release membrane inhibits scar formation at the site of peripheral nerve lesion.
abstract: Corticosteroids are widely used for the treatment of acute central nervous system injury. However, their bioactivity is limited by their short half-life. Sustained release of glucocorticoids can prolong their efficacy and inhibit scar formation at the site of nerve injury. In the present study, we wrapped the anastomotic ends of the rat sciatic nerve with a methylprednisolone sustained-release membrane. Compared with methylprednisone alone or methylprednisone microspheres, the methylprednisolone microsphere sustained-release membrane reduced tissue adhesion and inhibited scar tissue formation at the site of anastomosis. It also increased sciatic nerve function index and the thickness of the myelin sheath. Our findings show that the methylprednisolone microsphere sustained-release membrane effectively inhibits scar formation at the site of anastomosis of the peripheral nerve, thereby promoting nerve regeneration.
authors.affiliation: The Affiliated Dongnan Hospital of Xiamen University, Zhangzhou, Fujian Province, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.affiliation: The Affiliated Dongnan Hospital of Xiamen University, Zhangzhou, Fujian Province, China.
authors.forename: Teng
authors.initials: T
authors.lastname: Li
authors.affiliation: The Affiliated Dongnan Hospital of Xiamen University, Zhangzhou, Fujian Province, China.
authors.forename: Xiang-Chang
authors.initials: XC
authors.lastname: Cao
authors.affiliation: The Affiliated Dongnan Hospital of Xiamen University, Zhangzhou, Fujian Province, China.
authors.forename: De-Qing
authors.initials: DQ
authors.lastname: Luo
authors.affiliation: The Affiliated Dongnan Hospital of Xiamen University, Zhangzhou, Fujian Province, China.
authors.forename: Ke-Jian
authors.identifier: 0000-0001-7030-8009
authors.initials: KJ
authors.lastname: Lian
keywords: biological agents; methylprenisolone; nanometer; nerve regeneration; neural regeneration; peripheral nerve; peripheral nerve injury; scar; sustained-release membrane