title: Consequences of obstructive sleep apnoea syndrome on left ventricular geometry and diastolic function.
abstract: Obstructive sleep apnoea syndrome (OSAS) is a frequent sleep disorder that is known to be an independent risk factor for arterial hypertension (AHT). Potential confounding factors associated with both OSAS and AHT, such as age, diabetes mellitus and obesity, have been explored extensively, and are considered as independent but additive factors. However, these factors are also contributors to left ventricular (LV) hypertrophy (LVH) and LV diastolic dysfunction, both of which are important causes of cardiovascular morbidity, and have been reported to be associated with OSAS for decades. In this review, we present an overview of how OSAS may promote changes in LV geometry and diastolic dysfunction through its best-known cardiovascular complication, arterial hypertension. We also summarize the epidemiological links between OSAS and LVH, outline diastolic dysfunction in OSAS patients, and try to highlight the mechanisms responsible, focusing on the effect of confounding factors.
authors.affiliation: Department of Cardiology, Henri-Mondor University Hospital, Université Paris-Est-Créteil, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil cedex, France.
authors.forename: Diane
authors.initials: D
authors.lastname: Bodez
authors.affiliation: Department of Cardiology, Henri-Mondor University Hospital, Université Paris-Est-Créteil, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil cedex, France.
authors.forename: Thibaud
authors.initials: T
authors.lastname: Damy
authors.affiliation: Department of Cardiology, Saint-Antoine University and Medical School, Université Pierre-et-Marie-Curie, 184, rue du Faubourg-Saint-Antoine, 75571 Paris cedex 12, France.
authors.forename: Laurie
authors.initials: L
authors.lastname: Soulat-Dufour
authors.affiliation: Department of Cardiology, Rhône Durance Clinic, 1750, chemin du Lavarin, 84000 Avignon, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Meuleman
authors.affiliation: Department of Cardiology, Saint-Antoine University and Medical School, Université Pierre-et-Marie-Curie, 184, rue du Faubourg-Saint-Antoine, 75571 Paris cedex 12, France. Electronic address: ariel.cohen@aphp.fr.
authors.forename: Ariel
authors.initials: A
authors.lastname: Cohen
mesh_terms: D003971:Diastole; D004452:Echocardiography / Q000379:methods*; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D017286:Polysomnography; D012307:Risk Factors; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000150:complications* / Q000175:diagnosis; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000209:etiology*; D016277:Ventricular Function, Left / Q000502:physiology*
keywords: Arterial hypertension; Hypertension artérielle; Left ventricle; Obstructive sleep apnoea syndrome; Syndrome d’apnée du sommeil obstructive; Ventricule gauche