title: Tuning One-Dimensional Nanostructures of Bola-Like Peptide Amphiphiles by Varying the Hydrophilic Amino Acids.
abstract: By combining experimental measurements and computer simulations, we here show that for the bola-like peptide amphiphiles XI4 X, where X=K, R, and H, the hydrophilic amino acid substitutions have little effect on the β-sheet hydrogen-bonding between peptide backbones. Whereas all of the peptides self-assemble into one dimensional (1D) nanostructures with completely different morphologies, that is, nanotubes and helical nanoribbons for KI4 K, flat and multilayered nanoribbons for HI4 H, and twisted and bilayered nanoribbons for RI4 R. These different 1D morphologies can be explained by the distinct stacking degrees and modes of the three peptide β-sheets along the x-direction (width) and the z-direction (height), which microscopically originate from the hydrogen-bonding ability of the sheets to solvent molecules and the pairing of hydrophilic amino acid side chains between β-sheet monolayers through stacking interactions and hydrogen bonding. These different 1D nanostructures have distinct surface chemistry and functions, with great potential in various applications exploiting the respective properties of these hydrophilic amino acids.
authors.affiliation: Centre for Bioengineering and Biotechnology, China University of Petroleum (East China), Changjiang West Road, Qingdao, 266580, P. R. China.
authors.forename: Yurong
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Centre for Bioengineering and Biotechnology, China University of Petroleum (East China), Changjiang West Road, Qingdao, 266580, P. R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Deng
authors.affiliation: Centre for Bioengineering and Biotechnology, China University of Petroleum (East China), Changjiang West Road, Qingdao, 266580, P. R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Yang
authors.affiliation: Centre for Bioengineering and Biotechnology, China University of Petroleum (East China), Changjiang West Road, Qingdao, 266580, P. R. China.
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
authors.affiliation: School of Physics and Astronomy, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
authors.forename: Elias
authors.initials: E
authors.lastname: Pambou
authors.affiliation: School of Physics and Astronomy, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Lu
authors.affiliation: School of Physics and Astronomy, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
authors.forename: Zongyi
authors.initials: Z
authors.lastname: Li
authors.affiliation: Centre for Bioengineering and Biotechnology, China University of Petroleum (East China), Changjiang West Road, Qingdao, 266580, P. R. China.
authors.forename: Jiqian
authors.initials: J
authors.lastname: Wang
authors.affiliation: ISIS Pulsed Neutron Source, STFC Rutherford Appleton Laboratory, Harwell Oxford, Didcot, OX11 0QX, UK.
authors.forename: Stephen
authors.initials: S
authors.lastname: King
authors.affiliation: ISIS Pulsed Neutron Source, STFC Rutherford Appleton Laboratory, Harwell Oxford, Didcot, OX11 0QX, UK.
authors.forename: Sarah
authors.initials: S
authors.lastname: Rogers
authors.affiliation: Centre for Bioengineering and Biotechnology, China University of Petroleum (East China), Changjiang West Road, Qingdao, 266580, P. R. China. xuh@upc.edu.cn.
authors.forename: Hai
authors.initials: H
authors.lastname: Xu
authors.affiliation: School of Physics and Astronomy, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK. j.lu@manchester.ac.uk.
authors.forename: Jian R
authors.initials: JR
authors.lastname: Lu
mesh_terms: D000596:Amino Acids / Q000737:chemistry* / Q000378:metabolism; D006860:Hydrogen Bonding; D057927:Hydrophobic and Hydrophilic Interactions; D049329:Nanostructures / Q000737:chemistry*; D043942:Nanotubes / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism; D012997:Solvents / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D010455:Peptides; D012997:Solvents
keywords: amino acids; nanostructures; protein folding; self-assembly; short peptides