title: Observation of intracellular interactions between DNA origami and lysosomes by the fluorescence localization method.
abstract: We obtained the fluorescence localization images of tube DNA origami nanostructures in NIH 3T3 cells for the first time. The fluorescence localization images of tube DNA origami nanostructures and TIRF images of lysosomes were combined and they revealed the detailed interactions between the two structures. Quantitative analysis illustrated that the tube origami can be captured as well as degraded by lysosomes with time.
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Lab of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. jbli@iccas.ac.cn.
authors.forename: Meifang
authors.initials: M
authors.lastname: Fu
authors.forename: Luru
authors.initials: L
authors.lastname: Dai
authors.forename: Qiao
authors.initials: Q
authors.lastname: Jiang
authors.forename: Yunqing
authors.initials: Y
authors.lastname: Tang
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Zhang
authors.forename: Baoquan
authors.initials: B
authors.lastname: Ding
authors.forename: Junbai
authors.initials: J
authors.lastname: Li
mesh_terms: D004247:DNA / Q000737:chemistry*; D005453:Fluorescence; D008247:Lysosomes / Q000737:chemistry*; D008856:Microscopy, Fluorescence
chemical_list: D004247:DNA