title: Autophagy and Tubular Cell Death in the Kidney.
abstract: Many common renal insults such as ischemia and toxic injury primarily target the tubular epithelial cells, especially the highly metabolically active proximal tubular segment. Tubular epithelial cells are particularly dependent on autophagy to maintain homeostasis and respond to stressors. The pattern of autophagy in the kidney has a unique spatial and chronologic signature. Recent evidence has shown that there is complex cross-talk between autophagy and various cell death pathways. This review specifically discusses the interplay between autophagy and cell death in the renal tubular epithelia. It is imperative to review this topic because recent discoveries have improved our mechanistic understanding of the autophagic process and have highlighted its broad clinical applications, making autophagy a major target for drug development.
authors.affiliation: Department of Nephrology, Boston University Medical Center, Boston, MA. Electronic address: ahavasi@bu.edu.
authors.forename: Andrea
authors.initials: A
authors.lastname: Havasi
authors.affiliation: Department of Nephrology, Second Xiangya Hospital of Central South University, Changsha, China; Department of Cellular Biology and Anatomy, Medical College of Georgia and Charlie Norwood VA Medical Center, Augusta, GA.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Dong
mesh_terms: D058186:Acute Kidney Injury / Q000378:metabolism* / Q000473:pathology; D017209:Apoptosis; D001343:Autophagy; D006801:Humans; D007684:Kidney Tubules / Q000166:cytology / Q000378:metabolism* / Q000473:pathology; D015427:Reperfusion Injury / Q000378:metabolism* / Q000473:pathology
keywords: apoptosis; autophagy; cell death; renal tubule