title: New MAPS for misfolded proteins.
abstract: Clearing misfolded proteins from the cytoplasm is essential to maintain cellular homeostasis. Now, a parallel clearance system is described that uses the deubiquitylase USP19 to enable secretion of misfolded cytoplasmic proteins when conventional proteasomal degradation is compromised. Misfolding-associated protein secretion (MAPS) has important implications for protein quality control and prion-like transmission.
authors.affiliation: Ludwig Institute for Cancer Research, University of Oxford, Oxford OX2 6TT, UK.
authors.forename: Norbert
authors.initials: N
authors.lastname: Volkmar
authors.affiliation: Ludwig Institute for Cancer Research, University of Oxford, Oxford OX2 6TT, UK.
authors.forename: Emma
authors.initials: E
authors.lastname: Fenech
authors.affiliation: Ludwig Institute for Cancer Research, University of Oxford, Oxford OX2 6TT, UK.
authors.forename: John C
authors.initials: JC
authors.lastname: Christianson
mesh_terms: D000818:Animals; D003593:Cytoplasm / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D017510:Protein Folding; D021381:Protein Transport; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*
chemical_list: D044767:Ubiquitin-Protein Ligases; D046988:Proteasome Endopeptidase Complex