title: Lower Urinary Tract Symptoms and Efficacy of Anticholinergic Drugs in Patients Remaining Disease-Free After Radical Retropubic Prostatectomy.
abstract: OBJECTIVE
  This study was conducted to evaluate lower urinary tract symptoms (LUTS) change in patients with localized prostate cancer after radical retropubic prostatectomy (RRP) and examine the efficacy of anticholinergic drugs to treat patients suffering from storage symptoms.
  
  
  METHODS
  Among 50 patients who underwent RRP for prostate cancer, 40 who did not undergo additional treatment that might affect their urination pattern were included in the analysis. The International Prostate Symptom Score (IPSS), quality of life (QoL) score, and uroflowmetry were analyzed prior to RRP and 12 months after RRP. Twelve months after RRP, patients desiring improvement of storage symptoms were administered anticholinergic drugs for 6 months; the effects of such treatments were analyzed 3 and 6 months later.
  
  
  RESULTS
  Preoperatively and at 12 months after surgery, the mean IPSS for patients were 10.9 &plusmn; 6.7 and 9.2 &plusmn; 5.7, respectively. The mean IPSS for patients desiring improvement of storage symptoms before and after administration of medication were 9.7 &plusmn; 5.9 and 9.0 &plusmn; 4.4, respectively. In particular, the mean storage symptom composites improved significantly after administration of medication. There were no statistically significant differences in frequency between baseline and 3-month, but frequency was improved significantly after 6 months. Urgency and nocturia were improved significantly after 3 months.
  
  
  CONCLUSIONS
  In patients undergoing RRP, urinary symptoms change over time, with worsening storage symptoms. Our results suggest that, in patients who had discomfort with storage symptoms after RRP, anticholinergic drugs significantly improved symptoms and QoL.&nbsp.
authors.affiliation: Department of Urology, Chungnam National University School of Medicine, Daejeon, Korea.
authors.forename: Seung Woo
authors.initials: SW
authors.lastname: Yang
authors.affiliation: Department of Urology, Chungnam National University School of Medicine, Daejeon, Korea.
authors.forename: Yong Gil
authors.initials: YG
authors.lastname: Na
authors.affiliation: Department of Urology, Chungnam National University School of Medicine, Daejeon, Korea.
authors.forename: Ki Hak
authors.initials: KH
authors.lastname: Song
authors.affiliation: Department of Urology, Chungnam National University School of Medicine, Daejeon, Korea.
authors.forename: Ju Hyun
authors.initials: JH
authors.lastname: Shin
authors.affiliation: Department of Urology, Konyang University College of Medicine, Daejeon, Korea.
authors.forename: Young Seop
authors.initials: YS
authors.lastname: Chang
authors.affiliation: Department of Urology, Chungnam National University School of Medicine, Daejeon, Korea.
authors.forename: Jong Mok
authors.initials: JM
authors.lastname: Park
authors.affiliation: Department of Urology, Chungnam National University School of Medicine, Daejeon, Korea.
authors.forename: Chung Lyul
authors.initials: CL
authors.lastname: Lee
authors.affiliation: Department of Urology, Chungnam National University School of Medicine, Daejeon, Korea.
authors.forename: Jae Sung
authors.initials: JS
authors.lastname: Lim
mesh_terms: D000368:Aged; D018680:Cholinergic Antagonists / Q000627:therapeutic use*; D018572:Disease-Free Survival; D006801:Humans; D059411:Lower Urinary Tract Symptoms / Q000188:drug therapy* / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011468:Prostatectomy / Q000379:methods; D011471:Prostatic Neoplasms / Q000150:complications* / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D018680:Cholinergic Antagonists