title: Deterioration/relapse of depression during pregnancy in Japanese women associated with interruption of antidepressant medications.
abstract: This study examined the risk of deterioration/relapse in pregnant women who discontinued their antidepressant medications based on the discretion of the psychiatric specialists compared with those who performed self-interruption. We reviewed the obstetric records of all singleton deliveries beyond 22 weeks of gestation at Japanese Red Cross Katsushika Maternity Hospital from January 2009 through December 2015. Compared with the women continuing antidepressant medications throughout pregnancy, the incidence of deterioration/relapse was higher in the women who discontinued their antidepressant medications regardless of who made the decision (interruption based on the discretion of the psychiatric specialists: 61%, odds ratio (OR), 8.05; 95% confidence interval (CI), 2.4-27; p < 0.01; self-interruption: 63%, odds ratio (OR), 8.79; 95% confidence interval (CI), 2.6-29; p < 0.01 versus 16%). The continuation of medications and careful observation are required for pregnant women complicated by depressive disorders.
authors.affiliation: a Department of Obstetrics and Gynecology , Japanese Red Cross Katsushika Maternity Hospital , Tokyo , Japan.
authors.forename: Shunji
authors.initials: S
authors.lastname: Suzuki
authors.affiliation: a Department of Obstetrics and Gynecology , Japanese Red Cross Katsushika Maternity Hospital , Tokyo , Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kato
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D016022:Case-Control Studies; D003866:Depressive Disorder / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007564:Japan; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011256:Pregnancy Outcome; D012008:Recurrence; D012306:Risk; D012720:Severity of Illness Index; D028761:Withholding Treatment; D055815:Young Adult
chemical_list: D000928:Antidepressive Agents
keywords: Deterioration/relapse of depression; Japan; interruption of medications; pregnancy