title: Pleiotropic effects of herbs characterized with blood-activating and stasis-resolving functions on angiogenesis.
abstract: Accumulative evidences have underpinned the nature candidates from Chinese medicine (CM), particularly CM served as blood activating and stasis resolving (BASR, Huoxue Huayu in Chinese) by targeting tumor-associated angiogenesis. However, recent experiment research on the therapeutic angiogenesis by BASR-CM attracts wide attention and discussion. This opinion review focused on the underlying link between two indications and anticipated that (1) BASR-CM might emphasize on a balanced multi-cytokines network interaction; (2) BASR-CM might address on the nature of diseases prior to differently affecting physiological and pathological angiogenesis; (3) BASR-CM might mainly act on perivascular cells, either promotes arteriogenesis by increasing arteriogenic factors in ischemic diseases, or simultaneously keep a quiescent vasculature to impede angiogenesis in tumor context.
authors.affiliation: Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
authors.forename: Li
authors.initials: L
authors.lastname: Tao
authors.affiliation: Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Wang
authors.affiliation: Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.|Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
authors.forename: Ai-Yun
authors.initials: AY
authors.lastname: Wang
authors.affiliation: Department of Pharmacy, Provincial Hospital Affiliated to Anhui Medical University, Hefei, 230001, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Fujian Provincial Hospital, Clinical College of Fujian Medical University, Fuzhou, 350001, China.
authors.forename: Jun-Shan
authors.initials: JS
authors.lastname: Ruan
authors.affiliation: Department of Pharmacology, Hanlin College, Nanjing University of Chinese Medicine, Taizhou Jiangsu Province, 225300, China.
authors.forename: Fang-Tian
authors.initials: FT
authors.lastname: Fan
authors.affiliation: Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
authors.forename: Yu-Ping
authors.initials: YP
authors.lastname: Liu
authors.affiliation: Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Li
authors.affiliation: Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Yue
authors.affiliation: Department of Pharmaceutics, Jinling Hospital, Nanjing University School of Medicine, Nanjing, 210002, China.
authors.forename: Wen-Hui
authors.initials: WH
authors.lastname: Qian
authors.affiliation: Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.|Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
authors.forename: Wen-Xing
authors.initials: WX
authors.lastname: Chen
authors.affiliation: Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China. profyinlu@163.com.|Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing, 210023, China. profyinlu@163.com.
authors.forename: Yin
authors.initials: Y
authors.lastname: Lu
mesh_terms: D020533:Angiogenesis Inhibitors / Q000737:chemistry / Q000627:therapeutic use; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D008954:Models, Biological; D009389:Neovascularization, Pathologic / Q000097:blood* / Q000188:drug therapy*
chemical_list: D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D004365:Drugs, Chinese Herbal
keywords: Chinese medicine; anti-angiogenesis; arteriogenesis; blood activating and stasis resolving; pathological angiogenesis; physiological angiogenesis; pro-angiogenesis