title: Risk of Band Keratopathy in Patients with End-Stage Renal Disease.
abstract: This study is a retrospective, nationwide, matched cohort study to investigate the risk of band keratopathy following end-stage renal disease (ESRD). The study cohort included 94,039 ESRD on-dialysis patients identified by the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM), code 585 and registered between January 2000 to December 2009 at the Taiwan National Health Insurance Research Database. An age- and sex-matched control group comprised 94,039 patients selected from the Taiwan Longitudinal Health Insurance Database 2000. Information for each patient was collected from the index date until December 2011. In total, 230 ESRD patients and 26 controls had band keratopathy (P < 0.0001) during the follow-up period, indicating a significantly elevated risk of band keratopathy in the ESRD patients compared with controls (incidence rate ratio = 12.21, 95% confidence interval [CI] = 8.14-18.32). After adjustment for potential confounders including sarcoidosis, hyperparathyroidism, iridocyclitis, and phthisis bulbi, ESRD patients were 11.56 times more likely to develop band keratopathy in the full cohort (adjusted HR = 11.56, 95% CI = 7.70-17.35). In conclusion, ESRD increases the risk of band keratopathy. Close interdisciplinary collaboration between nephrologists and ophthalmologists is important to deal with band keratopathy following ESRD and prevent visual acuity impairments.
authors.affiliation: Department of Healthcare Administration and Medical Informatics, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors.forename: Shih-Feng
authors.initials: SF
authors.lastname: Weng
authors.affiliation: Department of Pediatrics, Chi Mei Medical Center, Liouying, Tainan, Taiwan.|Graduate Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Ren-Long
authors.initials: RL
authors.lastname: Jan
authors.affiliation: Department of Education, University of Taipei, Taipei, Taiwan.
authors.forename: Chun
authors.initials: C
authors.lastname: Chang
authors.affiliation: Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan.|Department of Anesthesiology, Chi Mei Medical Center, Tainan, Taiwan.
authors.forename: Jhi-Joung
authors.initials: JJ
authors.lastname: Wang
authors.affiliation: Department of Occupational Medicine, Chi Mei Medical Center, Tainan, Taiwan.|Department of Leisure, Recreation and Tourism Management, Southern Taiwan University of Science and Technology, Tainan, Taiwan.
authors.forename: Shih-Bin
authors.initials: SB
authors.lastname: Su
authors.affiliation: Department of Occupational Medicine, Chi Mei Medical Center, Tainan, Taiwan.|Department of Child Care and Education, Southern Taiwan University of Science and Technology, Tainan, Taiwan.
authors.forename: Chien-Cheng
authors.initials: CC
authors.lastname: Huang
authors.affiliation: Department of Ophthalmology, Chi Mei Medical Center, Tainan, Taiwan.|Department of Ophthalmology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Sung-Huei
authors.initials: SH
authors.lastname: Tseng
authors.affiliation: Department of Ophthalmology, Chi Mei Medical Center, Tainan, Taiwan.|Graduate Institute of Medical Science, College of Health Science, Chang Jung Christian University, Tainan, Taiwan.
authors.forename: Yuh-Shin
authors.initials: YS
authors.lastname: Chang
mesh_terms: D000328:Adult; D000368:Aged; D003317:Corneal Dystrophies, Hereditary / Q000453:epidemiology / Q000209:etiology; D016208:Databases, Factual; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000150:complications / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology