title: Osteochondral alteration in a child treated with levetiracetam: a rare case of juvenile osteochondritis dissecans of the talar head.
abstract: Levetiracetam is a relatively novel antiepileptic drug used for the treatment of partial and generalized seizures in adult and children. Several animal studies describe a possible drug adverse effect on skeletal growth and metabolism. We present a case report of a 10-year-old female child who underwent a prolonged 7-year treatment with levetiracetam for sporadic secondary convulsions secondary to enterovirus encephalitis at the age of 15 months. This patient developed an osteochondritis dissecans lesion (OCD) of the talar head well treated conservatively. Only a few cases have been described of this rare type of OCD. We hypothesize a possible association between levetiracetam therapy and OCD development, suggesting the importance of long-term control of bone growth in levetiracetam-treated pediatric populations.
authors.affiliation: aDepartment of Pediatric Orthopaedics, Saint Joseph Hospital, Marseille bDepartment of Paediatric Orthopedic Surgery, Hopital Couple Enfants, Grenoble Alpes University, Grenoble, France cDepartment of Orthopedic, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Turati
authors.forename: Yann
authors.initials: Y
authors.lastname: Glard
authors.forename: David
authors.initials: D
authors.lastname: Afonso
authors.forename: Jacques
authors.initials: J
authors.lastname: Griffet
authors.forename: Marco
authors.initials: M
authors.lastname: Bigoni
mesh_terms: D000700:Analgesics / Q000627:therapeutic use; D000927:Anticonvulsants / Q000009:adverse effects*; D001915:Braces; D002648:Child; D000072700:Conservative Treatment; D005260:Female; D006801:Humans; D000077287:Levetiracetam; D008279:Magnetic Resonance Imaging; D010008:Osteochondritis Dissecans / Q000175:diagnosis* / Q000209:etiology*; D010372:Pediatrics; D010889:Piracetam / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016059:Range of Motion, Articular; D013628:Talus / Q000473:pathology*; D016474:Weight-Bearing
chemical_list: D000700:Analgesics; D000927:Anticonvulsants; D000077287:Levetiracetam; D010889:Piracetam