title: Flexible Substrate-Based Devices for Point-of-Care Diagnostics.
abstract: Point-of-care (POC) diagnostics play an important role in delivering healthcare, particularly for clinical management and disease surveillance in both developed and developing countries. Currently, the majority of POC diagnostics utilize paper substrates owing to affordability, disposability, and mass production capability. Recently, flexible polymer substrates have been investigated due to their enhanced physicochemical properties, potential to be integrated into wearable devices with wireless communications for personalized health monitoring, and ability to be customized for POC diagnostics. Here, we focus on the latest advances in developing flexible substrate-based diagnostic devices, including paper and polymers, and their clinical applications.
authors.affiliation: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, 310003, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, Zhejiang Province, 310003, China; Institute for Translational Medicine, Zhejiang University, Hangzhou, Zhejiang Province, 310029, China; Bio-Acoustic MEMS in Medicine (BAMM) Laboratory, Canary Center at Stanford for Cancer Early Detection, Department of Radiology, Stanford University, School of Medicine, Palo Alto, CA 94304, USA. Electronic address: shuqi@zju.edu.cn.
authors.forename: ShuQi
authors.initials: S
authors.lastname: Wang
authors.affiliation: Bio-Acoustic MEMS in Medicine (BAMM) Laboratory, Canary Center at Stanford for Cancer Early Detection, Department of Radiology, Stanford University, School of Medicine, Palo Alto, CA 94304, USA.
authors.forename: Thiruppathiraja
authors.initials: T
authors.lastname: Chinnasamy
authors.affiliation: Bio-Acoustic MEMS in Medicine (BAMM) Laboratory, Canary Center at Stanford for Cancer Early Detection, Department of Radiology, Stanford University, School of Medicine, Palo Alto, CA 94304, USA.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Lifson
authors.affiliation: Bio-Acoustic MEMS in Medicine (BAMM) Laboratory, Canary Center at Stanford for Cancer Early Detection, Department of Radiology, Stanford University, School of Medicine, Palo Alto, CA 94304, USA.
authors.forename: Fatih
authors.initials: F
authors.lastname: Inci
authors.affiliation: Bio-Acoustic MEMS in Medicine (BAMM) Laboratory, Canary Center at Stanford for Cancer Early Detection, Department of Radiology, Stanford University, School of Medicine, Palo Alto, CA 94304, USA; Department of Electrical Engineering (by courtesy), Stanford University, Stanford, CA 94305, USA. Electronic address: utkan@stanford.edu.
authors.forename: Utkan
authors.initials: U
authors.lastname: Demirci
mesh_terms: D003020:Clothing; D006801:Humans; D056656:Lab-On-A-Chip Devices; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D008991:Monitoring, Physiologic / Q000295:instrumentation*; D010209:Paper; D018583:Pliability; D019095:Point-of-Care Systems; D011108:Polymers; D013784:Textiles
chemical_list: D011108:Polymers
keywords: flexible substrate; paper; point-of-care diagnostics; polymer; wearable devices