title: Negative functional coupling between the right fronto-parietal and limbic resting state networks predicts increased self-control and later substance use onset in adolescence.
abstract: Recent developmental brain imaging studies have demonstrated that negatively coupled prefrontal-limbic circuitry implicates the maturation of brain development in adolescents. Using resting-state functional magnetic resonance imaging (rs-fMRI) and independent component analysis (ICA), the present study examined functional network coupling between prefrontal and limbic systems and links to self-control and substance use onset in adolescents. Results suggest that negative network coupling (anti-correlated temporal dynamics) between the right fronto-parietal and limbic resting state networks is associated with greater self-control and later substance use onset in adolescents. These findings increase our understanding of the developmental importance of prefrontal-limbic circuitry for adolescent substance use at the resting-state network level.
authors.affiliation: Department of Psychology, University of Illinois at Urbana-Champaign (UIUC), United States.
authors.forename: Tae-Ho
authors.initials: TH
authors.lastname: Lee
authors.affiliation: Department of Psychology, University of Illinois at Urbana-Champaign (UIUC), United States; Beckman Institute for Advanced Science and Technology, UIUC, United States. Electronic address: ehtelzer@illinois.edu.
authors.forename: Eva H
authors.initials: EH
authors.lastname: Telzer
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior / Q000523:psychology; D001931:Brain Mapping / Q000379:methods; D002648:Child; D005260:Female; D005625:Frontal Lobe / Q000254:growth & development*; D006801:Humans; D008032:Limbic System / Q000254:growth & development*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009415:Nerve Net / Q000254:growth & development*; D010296:Parietal Lobe / Q000254:growth & development*; D011237:Predictive Value of Tests; D012146:Rest / Q000502:physiology / Q000523:psychology; D000068356:Self-Control / Q000523:psychology*; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000523:psychology*
keywords: Adolescence; Fronto-parietal network (FPN); Independent component analysis (ICA); Intrinsic network connectivity; Limbic network; Resting-state fMRI; Risk-taking behavior