title: Association between KIR genotypes and HLA-B alleles on viral load in Southern Brazilian individuals infected by HIV-1 subtypes B and C.
abstract: There is a great variety of HIV-1 subtypes circulating in Brazil, including subtype C, whose prevalence is on the rise, particularly in the southern region. Many host and viral genetic factors may be involved in this trend. We evaluated the influence of human leukocyte antigen (HLA) class I alleles and killer-cell immunoglobulin-like receptor (KIR) genotypes on viral set point and T-CD4(+) parameters in 84 treatment-naïve HIV-1-positive individuals. Frequency data in the infected group were compared to data of 548 healthy control subjects. Individuals with the KIR AA genotype had a higher viral load (VL) than individuals with the KIR Bx genotype. The HIV-1 group was subdivided into three subgroups according to HLA-B allele presence: those with protection to disease alleles (HLA-B(+)), accelerated disease progression alleles (HLA-B(-)), or neither (HLA-B(o)) were grouped. We observed a significant effect of the HLA-B allele presence on VL. The HLA-B(+) group had significantly lower VL than the HLA-B(-) group and trended toward a lower VL than the HLA-B(o) group. There were significant differences between groups expressing extreme VL values: KIR-AA+HLA-B(-) vs. KIR Bx+HLA-B(+) and KIR-AA+HLA-B(o)vs. KIR Bx+HLA-B(+). The relationship of KIR/HLA host genetics with slow HIV disease progression in southern Brazil may be useful for vaccine developers, epidemiologists, and clinicians.
authors.affiliation: Laboratório de Histocompatibilidade e Criopreservação, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Juliana
authors.initials: J
authors.lastname: Fernandes-Cardoso
authors.affiliation: Serviço de Assistência Especializada em DST/AIDS, Prefeitura Municipal de Porto Alegre, Porto Alegre, Brazil.
authors.forename: Theodoro Armando
authors.initials: TA
authors.lastname: Süffert
authors.affiliation: Serviço de Assistência Especializada em DST/AIDS, Prefeitura Municipal de Porto Alegre, Porto Alegre, Brazil.
authors.forename: Maria da Gloria
authors.initials: MDG
authors.lastname: Correa
authors.affiliation: Departamento de Imunologia, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
authors.forename: Luiz Fernando Job
authors.initials: LFJ
authors.lastname: Jobim
authors.affiliation: Departamento de Imunologia, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
authors.forename: Mariana
authors.initials: M
authors.lastname: Jobim
authors.affiliation: Departamento de Imunologia, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
authors.forename: Patricia Hartstein
authors.initials: PH
authors.lastname: Salim
authors.affiliation: Laboratório de Virologia Molecular, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Monica Barcelos
authors.initials: MB
authors.lastname: Arruda
authors.affiliation: Laboratório de Virologia Molecular, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Lidia Theodoro
authors.initials: LT
authors.lastname: Boullosa
authors.affiliation: Laboratório de Virologia Molecular, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Amilcar
authors.initials: A
authors.lastname: Tanuri
authors.affiliation: Laboratório de Histocompatibilidade e Criopreservação, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Luis Cristóvão
authors.initials: LC
authors.lastname: Porto
authors.affiliation: Laboratório de Virologia Molecular, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: jcardosobio@gmail.com.
authors.forename: Orlando C
authors.initials: OC
authors.lastname: Ferreira
mesh_terms: D000328:Adult; D000368:Aged; D001938:Brazil; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015658:HIV Infections / Q000235:genetics*; D015497:HIV-1 / Q000502:physiology*; D015796:HLA-B27 Antigen / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D054340:Receptors, KIR / Q000235:genetics*; D019562:Viral Load; D055815:Young Adult
chemical_list: C090660:HLA-B protein, human; D015796:HLA-B27 Antigen; D054340:Receptors, KIR
keywords: Disease progression; HIV; HLA; KIR genotype; Viral load