title: Biodistribution and toxicity of orally administered poly (lactic-co-glycolic) acid nanoparticles to F344 rats for 21 days.
abstract: Quantify the biodistribution and assess the toxicity of PLGA (poly-lactic-co-glycolic acid) and surface-modified PLGA chitosan (PLGA/Chi) nanoparticles (NPs) orally administered for 7, 14 and 21 days to F344 rats.
  
  
  
  Fluorescent NPs were tracked in F344 rat tissues, and toxicity was evaluated by alkaline phosphatase and alanine transaminase levels, and by histologic examination of tissue samples.
  
  
  
  Biodistribution of PLGA and PLGA/Chi were similar, with highest amounts found in the intestine and liver. Alkaline phosphatase increased significantly in treated rats. Mild histological differences were detected in the intestine and liver.
  
  
  
  PLGA and PLGA/Chi NPs behaved similarly presenting minimal toxicity in the liver and intestine, but not in kidney, lung and brain.
authors.affiliation: 149 EB Doran Bldg., Biological & Agricultural Engineering Department, LSU & LSU AgCenter, Baton Rouge, LA 70803, USA.
authors.forename: Sara M
authors.initials: SM
authors.lastname: Navarro
authors.affiliation: A1218 Pathobiology & Population Medicine, College of Veterinary Medicine, PO Box 6100, Mississippi State, MS 39762-6100, USA.
authors.forename: Timothy W
authors.initials: TW
authors.lastname: Morgan
authors.affiliation: 149 EB Doran Bldg., Biological & Agricultural Engineering Department, LSU & LSU AgCenter, Baton Rouge, LA 70803, USA.
authors.forename: Carlos E
authors.initials: CE
authors.lastname: Astete
authors.affiliation: 1527 Division of Laboratory Animal Medicine, Pathobiological Sciences, School of Veterinary Medicine, LSU, Baton Rouge, LA 70803, USA.
authors.forename: Rhett W
authors.initials: RW
authors.lastname: Stout
authors.affiliation: 149 EB Doran Bldg., Biological & Agricultural Engineering Department, LSU & LSU AgCenter, Baton Rouge, LA 70803, USA.
authors.forename: Diana
authors.initials: D
authors.lastname: Coulon
authors.affiliation: 1527 Division of Laboratory Animal Medicine, Pathobiological Sciences, School of Veterinary Medicine, LSU, Baton Rouge, LA 70803, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Mottram
authors.affiliation: 149 EB Doran Bldg., Biological & Agricultural Engineering Department, LSU & LSU AgCenter, Baton Rouge, LA 70803, USA.
authors.forename: Cristina M
authors.initials: CM
authors.lastname: Sabliov
mesh_terms: D000284:Administration, Oral; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D048271:Chitosan / Q000737:chemistry; D004337:Drug Carriers; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry* / Q000493:pharmacokinetics* / Q000633:toxicity; D053758:Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D010316:Particle Size; D011100:Polyglycolic Acid / Q000737:chemistry* / Q000493:pharmacokinetics* / Q000633:toxicity; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011916:Rats, Inbred F344; D013499:Surface Properties; D014018:Tissue Distribution; D059551:Toxicity Tests, Subacute
chemical_list: D004337:Drug Carriers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D048271:Chitosan; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase
keywords: biodistribution; nanoparticles; toxicity