title: Comparison between intrarticular injection of hyaluronic acid, oxygen ozone, and the combination of both in the treatment of knee osteoarthrosis.
abstract: This study aimed to compare short-term clinical outcomes between intra-articular injection of hyaluronic acid (HA), oxygen ozone (O2O3), and the combination of both, in patients affected by osteoarthrosis (OA) of the knee. Seventy patients (age 45-75 years) with knee OA were randomized to intra-articular injections of HA (n=23), or O2O3 (n=23) or combined (n=24) one per week for 5 consecutive weeks. KOOS questionnaire and visual analog scale (VAS), before treatment (pre) at the end (post), and at 2 months after treatment ended (follow-up) were used as outcome measures. Analysis showed a significant effect (P < 0.05) of the conditions (pre, post and follow-up) in all parameters of the KOOS score and a significant effect (P < 0.05) of groups (HA, O2O3 and combined) for pain, symptoms, activities of daily living and quality of life. The combined group scores were higher compared to the HA and O2O3 groups, especially at follow-up. The combination of O2O3 and HA treatment led to a significantly better outcome especially at 2-month follow-up compared to HA and O2O3 given separately to patients affected by OA of the knee.
authors.affiliation: Department of Human, Motor and Health Sciences, University of Rome "Foro Italico", Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Giombini
authors.affiliation: Department of Human, Motor and Health Sciences, University of Rome "Foro Italico", Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Menotti
authors.affiliation: UOC Unit of Physical Medicine and Rehabilitation, Azienda Ospedaliera Policlinico Umberto I, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Di Cesare
authors.affiliation: Unit of Ozonetherapy, S.Pietro Fatebenefratelli Hospital, Rome.
authors.forename: F
authors.initials: F
authors.lastname: Giovannangeli
authors.affiliation: Unit of Ozonetherapy, S.Pietro Fatebenefratelli Hospital, Rome.
authors.forename: M
authors.initials: M
authors.lastname: Rizzo
authors.affiliation: University of Molise, Campobasso, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Moffa
authors.affiliation: Unit of Ozonetherapy, S.Pietro Fatebenefratelli Hospital, Rome.
authors.forename: F
authors.initials: F
authors.lastname: Martinelli
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D004338:Drug Combinations; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D007270:Injections, Intra-Articular; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000188:drug therapy* / Q000523:psychology; D010126:Ozone / Q000008:administration & dosage*; D011788:Quality of Life; D064232:Visual Analog Scale
chemical_list: D004338:Drug Combinations; D010126:Ozone; D006820:Hyaluronic Acid