title: Paraneoplastic Dermatomyositis Associated with Metastatic Seminoma.
abstract: We report the first case in Japan of paraneoplastic dermatomyositis with pure seminoma, a tumor that extremely rarely accompanies dermatomyositis. The patient presented to the hospital with muscle weakness and erythema and was diagnosed with dermatomyositis from skin biopsy. Routine radiological screening revealed testicular tumor and massive lymph node metastases. We initially performed orchiectomy along with conventional immunotherapy. However, muscle weakness gradually worsened, and he eventually showed dysphagia and forced respiration and became bedridden. Although he seemed close to being too unstable to tolerate further treatment, we started carefully adjusted chemotherapy comprising 4 courses of etoposide plus cisplatin, which proved highly successful. Lymph node metastases completely disappeared and swallowing and respiration fully normalized after completing chemotherapy. We believe that this clinical success was due to our decision to initiate chemotherapy even in such a weak patient.
authors.affiliation: Department of Urology, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan.
authors.forename: Hidekazu
authors.identifier: 0000-0001-5474-8725
authors.initials: H
authors.lastname: Yoshie
authors.affiliation: Department of Urology, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan.
authors.forename: Ryuto
authors.initials: R
authors.lastname: Nakazawa
authors.affiliation: Department of Urology, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan.
authors.forename: Wataru
authors.initials: W
authors.lastname: Usuba
authors.affiliation: Department of Urology, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan.
authors.forename: Hiroya
authors.initials: H
authors.lastname: Kudo
authors.affiliation: Department of Urology, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Sato
authors.affiliation: Department of Urology, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan.
authors.forename: Hideo
authors.initials: H
authors.lastname: Sasaki
authors.affiliation: Department of Urology, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Chikaraishi