title: Non-tumour bone marrow lymphocytes correlate with improved overall survival in childhood acute lymphoblastic leukaemia.
abstract: Composition of tumour immune cell infiltrates correlates with response to treatment and overall survival (OS) in several cancer settings. We retrospectively examined immune cells present in diagnostic bone marrow aspirates from paediatric patients with B-cell acute lymphoblastic leukaemia. Our analysis identified a sub-group (∼30% of patients) with >2.37% CD20 and >6.05% CD7 expression, which had 100% OS, and a sub-group (∼30% of patients) with ≤2.37% CD20 and ≤6.05% CD7 expression at increased risk of treatment failure (66.7% OS, P < 0.05). Immune cell infiltrate at diagnosis may predict treatment response and could provide a means to enhance immediate treatment risk stratification.
authors.affiliation: Department of Women's and Children's Health, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
authors.forename: Claire
authors.initials: C
authors.lastname: Edwin
authors.affiliation: Department of Haematology, Alder Hey Children's NHS Foundation Trust, Eaton Road, Liverpool, UK.
authors.forename: Joanne
authors.initials: J
authors.lastname: Dean
authors.affiliation: Department of Biostatistics, Institute of Translational Medicine, University of Liverpool, UK.
authors.forename: Laura
authors.initials: L
authors.lastname: Bonnett
authors.affiliation: Department of Women's and Children's Health, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
authors.forename: Kate
authors.initials: K
authors.lastname: Phillips
authors.affiliation: Department of Haematology and Oncology, Alder Hey Children's NHS Foundation Trust, Eaton Road, Liverpool, UK.
authors.forename: Russell
authors.initials: R
authors.lastname: Keenan
mesh_terms: D018951:Antigens, CD20 / Q000032:analysis; D019011:Antigens, CD7 / Q000032:analysis; D001853:Bone Marrow / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000276:immunology / Q000401:mortality*; D012189:Retrospective Studies
chemical_list: D018951:Antigens, CD20; D019011:Antigens, CD7
keywords: acute lymphoblastic leukaemia; immunophenotype; lymphocyte; overall survival; paediatric cancer