title: Real-World Multicenter Registry of Patients with Severe Coronary Artery Calcification Undergoing Orbital Atherectomy.
abstract: OBJECTIVE
  We evaluated the safety and efficacy of orbital atherectomy in real-world patients with severe coronary artery calcification (CAC).
  
  
  BACKGROUND
  The presence of severe CAC increases the complexity of percutaneous coronary intervention as it may impede stent delivery and optimal stent expansion. Atherectomy may be an indispensable tool for uncrossable or undilatable lesions by modifying severe CAC. Although the ORBIT I and II trials report that orbital atherectomy was safe and effective for the treatment of severe CAC, patients with kidney disease, recent myocardial infarction, long diffuse disease, severe left ventricular dysfunction, and unprotected left main disease were excluded.
  
  
  METHODS
  This retrospective study included 458 consecutive patients with severe CAC who underwent orbital atherectomy followed by stenting from October 2013 to December 2015 at 3 centers.
  
  
  RESULTS
  The primary endpoint of major adverse cardiac and cerebrovascular events at 30 days was 1.7%. Low rates of 30-day all-cause mortality (1.3%), myocardial infarction (1.1%), target vessel revascularization (0%), stroke (0.2%), and stent thrombosis (0.9%) were observed. Angiographic complications were low: perforation was 0.7%, dissection 0.9%, and no-reflow 0.7%. Emergency coronary artery bypass graft surgery was performed in 0.2% of patients.
  
  
  CONCLUSIONS
  In the largest real-world study of patients who underwent orbital atherectomy, including high-risk patients who were not surgical candidates as well as those with very complex coronary anatomy, acute and short-term adverse clinical event rates were low. A randomized clinical trial is needed to identify the ideal treatment strategy for patients with severe CAC.
authors.affiliation: Division of Interventional Cardiology, UCLA Medical Center, Los Angeles, California.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Lee
authors.affiliation: Division of Cardiology, Northwell Health, Manhasset, New York.
authors.forename: Evan
authors.initials: E
authors.lastname: Shlofmitz
authors.affiliation: Division of Cardiology, Northwell Health, Manhasset, New York.
authors.forename: Barry
authors.initials: B
authors.lastname: Kaplan
authors.affiliation: Division of Cardiology, Northwell Health, Manhasset, New York.
authors.forename: Dragos
authors.initials: D
authors.lastname: Alexandru
authors.affiliation: Division of Cardiology, Northwell Health, Manhasset, New York.
authors.forename: Perwaiz
authors.initials: P
authors.lastname: Meraj
authors.affiliation: Division of Cardiology, St. Francis Hospital, Roslyn, New York.
authors.forename: Richard
authors.initials: R
authors.lastname: Shlofmitz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017225:Atherectomy, Coronary / Q000009:adverse effects / Q000379:methods; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000379:methods; D011183:Postoperative Complications / Q000175:diagnosis / Q000453:epidemiology; D012042:Registries; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome; D061205:Vascular Calcification / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery