title: Bone mechanical properties and changes with osteoporosis.
abstract: This review will define the role of collagen and within-bone heterogeneity and elaborate the importance of trabecular and cortical architecture with regard to their effect on the mechanical strength of bone. For each of these factors, the changes seen with osteoporosis and ageing will be described and how they can compromise strength and eventually lead to bone fragility.
authors.affiliation: Division of Orthopaedic Trauma, Department of Orthopaedic Surgery, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Georg
authors.initials: G
authors.lastname: Osterhoff
authors.affiliation: Department of Mechanical Engineering, Boston University, Boston, MA02215, USA.
authors.forename: Elise F
authors.initials: EF
authors.lastname: Morgan
authors.affiliation: Department of Mechanical and Industrial Engineering, Northeastern University, Boston, MA02115, USA.
authors.forename: Sandra J
authors.initials: SJ
authors.lastname: Shefelbine
authors.affiliation: Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center and Department of Orthopedic Surgery, Harvard Medical School, Boston, MA02215, USA.
authors.forename: Lamya
authors.initials: L
authors.lastname: Karim
authors.affiliation: Centre for Biomechanics Research (BMEC), Department of Biomedical Engineering, NUI Galway, Galway, Republic of Ireland; National Centre for Biomedical Engineering Science (NCBES), NUI Galway, Galway, Republic of Ireland.
authors.forename: Laoise M
authors.initials: LM
authors.lastname: McNamara
authors.affiliation: Institute of Biomechanics, Trauma Center Murnau, Murnau, Germany; Paracelsus Medical University Salzburg, Salzburg, Austria. Electronic address: biomechanik@bgu-murnau.de.
authors.forename: Peter
authors.initials: P
authors.lastname: Augat
mesh_terms: D000375:Aging; D001696:Biomechanical Phenomena; D015519:Bone Density; D016723:Bone Remodeling / Q000502:physiology*; D003094:Collagen / Q000378:metabolism*; D006801:Humans; D010011:Osteocytes / Q000502:physiology*; D010024:Osteoporosis / Q000503:physiopathology*; D016474:Weight-Bearing
chemical_list: D003094:Collagen
keywords: Biomechanics; Bone fragility; Bone loss; Bone resorption; Collagen