title: Preparation and release study of Triclosan in polyethylene/Triclosan anti-bacterial blend.
abstract: In this study, medium density polyethylene (MDPE) incorporated with Triclosan antibacterial substance has been prepared and Triclosan release rate was investigated. The crystallinity level and matrix polarity, as two significant parameters in antibacterial release control, were studied. Triclosan, a well-established widespread antibacterial agent, was incorporated into medium density polyethylene (MDPE) and Maleic anhydride grafted polyethylene (PE-g-MA) was used to change the polarity of the MDPE matrix. A masterbatch of 10wt% Triclosan incorporated with the MDPE and various PE-g-MA concentrations were prepared using an internal mixer. Then the masterbatch was diluted in the MDPE matrix to produce compounds with 0.1, 0.5, and1wt% Triclosan via twin screw extruder. The compounds were molded by compression molding method and then were cooled in three different cooling rate methods: isothermal cooling (I), quenching (Q),and moderate 5-10°C/min cooling rate (M). Cooling rate effects on crystallinity level were investigated applying sample density measurement. UV-vis absorption spectroscopy was used to probe the release of Triclosan. Antibacterial properties of the compounds against Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus were measured. The results showed that by addition of PE-g-MA, Triclosan release rate was increased. It was confirmed that the sample crystallinity was decreased by the cooling rate enhancement. The results also showed that quenched samples indicated higher release of Triclosan. Cooling rate reduction and raising the polarity increased the release of Triclosan and improved the antibacterial properties of the compounds.
authors.affiliation: Department of Chemical Engineering (Polymer group), Isfahan University of Technology, Isfahan 84156-83111, Iran.
authors.forename: Jamshid
authors.initials: J
authors.lastname: Kamalipour
authors.affiliation: Department of Chemical Engineering (Polymer group), Isfahan University of Technology, Isfahan 84156-83111, Iran. Electronic address: mmasoomi@cc.iut.ac.ir.
authors.forename: Mahmood
authors.initials: M
authors.lastname: Masoomi
authors.affiliation: Iran Polymer and Petrochemical Institute, P.O. Box 14965/115, Tehran, Iran.
authors.forename: Hossein Ali
authors.initials: HA
authors.lastname: Khonakdar
authors.affiliation: Department of Chemical Engineering (Polymer group), Isfahan University of Technology, Isfahan 84156-83111, Iran.
authors.forename: Seyed Mohammad Reza
authors.initials: SMR
authors.lastname: Razavi
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D065546:Drug Liberation; D004926:Escherichia coli / Q000187:drug effects; D007711:Klebsiella pneumoniae / Q000187:drug effects; D020959:Polyethylene / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects; D014260:Triclosan / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D014260:Triclosan; D020959:Polyethylene
keywords: Antibacterial; Control release; Maleic anhydride; Polyethylene; Triclosan