title: A Series of Cinchona-Derived N-Oxide Phase-Transfer Catalysts: Application to the Photo-Organocatalytic Enantioselective α-Hydroxylation of β-Dicarbonyl Compounds.
abstract: A series of cinchona-derived N-oxide asymmetric phase-transfer catalysts were synthesized and applied in the enantioselective photo-organocatalytic α-hydroxylation of β-keto esters and β-keto amides (23 examples) using molecular oxygen in excellent yields (up to 98%) and high enantioselectivities (up to 83% ee). These new catalysts could be recycled and reused six times for such a reaction with almost the original reactivity and enantioselectivity.
authors.affiliation: State Key Laboratory of Fine Chemicals, School of Pharmaceutical Science and Technology, Dalian University of Technology , No. 2 Linggong Road, Dalian 116024 Liaoning Province, P. R. China.
authors.forename: Yakun
authors.initials: Y
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Fine Chemicals, School of Pharmaceutical Science and Technology, Dalian University of Technology , No. 2 Linggong Road, Dalian 116024 Liaoning Province, P. R. China.
authors.forename: Hang
authors.initials: H
authors.lastname: Yin
authors.affiliation: State Key Laboratory of Fine Chemicals, School of Pharmaceutical Science and Technology, Dalian University of Technology , No. 2 Linggong Road, Dalian 116024 Liaoning Province, P. R. China.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Tang
authors.affiliation: State Key Laboratory of Fine Chemicals, School of Pharmaceutical Science and Technology, Dalian University of Technology , No. 2 Linggong Road, Dalian 116024 Liaoning Province, P. R. China.
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Fine Chemicals, School of Pharmaceutical Science and Technology, Dalian University of Technology , No. 2 Linggong Road, Dalian 116024 Liaoning Province, P. R. China.
authors.forename: Qingwei
authors.initials: Q
authors.lastname: Meng
authors.affiliation: State Key Laboratory of Fine Chemicals, School of Pharmaceutical Science and Technology, Dalian University of Technology , No. 2 Linggong Road, Dalian 116024 Liaoning Province, P. R. China.
authors.forename: Zhanxian
authors.initials: Z
authors.lastname: Gao