title: Structural basis of potent Zika-dengue virus antibody cross-neutralization.
abstract: Zika virus is a member of the Flavivirus genus that had not been associated with severe disease in humans until the recent outbreaks, when it was linked to microcephaly in newborns in Brazil and to Guillain-Barré syndrome in adults in French Polynesia. Zika virus is related to dengue virus, and here we report that a subset of antibodies targeting a conformational epitope isolated from patients with dengue virus also potently neutralize Zika virus. The crystal structure of two of these antibodies in complex with the envelope protein of Zika virus reveals the details of a conserved epitope, which is also the site of interaction of the envelope protein dimer with the precursor membrane (prM) protein during virus maturation. Comparison of the Zika and dengue virus immunocomplexes provides a lead for rational, epitope-focused design of a universal vaccine capable of eliciting potent cross-neutralizing antibodies to protect simultaneously against both Zika and dengue virus infections.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Barba-Spaeth
authors.forename: Wanwisa
authors.initials: W
authors.lastname: Dejnirattisai
authors.forename: Alexander
authors.initials: A
authors.lastname: Rouvinski
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Vaney
authors.forename: Iris
authors.initials: I
authors.lastname: Medits
authors.forename: Arvind
authors.initials: A
authors.lastname: Sharma
authors.forename: Etienne
authors.initials: E
authors.lastname: Simon-Lorière
authors.forename: Anavaj
authors.initials: A
authors.lastname: Sakuntabhai
authors.forename: Van-Mai
authors.initials: VM
authors.lastname: Cao-Lormeau
authors.forename: Ahmed
authors.initials: A
authors.lastname: Haouz
authors.forename: Patrick
authors.initials: P
authors.lastname: England
authors.forename: Karin
authors.initials: K
authors.lastname: Stiasny
authors.forename: Juthathip
authors.initials: J
authors.lastname: Mongkolsapaya
authors.forename: Franz X
authors.initials: FX
authors.lastname: Heinz
authors.forename: Gavin R
authors.initials: GR
authors.lastname: Screaton
authors.forename: Félix A
authors.initials: FA
authors.lastname: Rey
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology; D057134:Antibodies, Neutralizing / Q000276:immunology*; D000936:Antigen-Antibody Complex / Q000737:chemistry / Q000276:immunology; D001938:Brazil; D003429:Cross Reactions / Q000276:immunology*; D018360:Crystallography, X-Ray; D003715:Dengue / Q000276:immunology; D053059:Dengue Vaccines / Q000737:chemistry / Q000276:immunology; D003716:Dengue Virus / Q000737:chemistry / Q000276:immunology*; D000939:Epitopes / Q000737:chemistry* / Q000276:immunology; D006801:Humans; D008958:Models, Molecular; D010802:Phylogeny; D014759:Viral Envelope Proteins / Q000737:chemistry / Q000276:immunology; D014765:Viral Vaccines / Q000737:chemistry* / Q000276:immunology; D000071244:Zika Virus / Q000737:chemistry / Q000276:immunology*; D000071243:Zika Virus Infection / Q000276:immunology / Q000517:prevention & control
chemical_list: D000911:Antibodies, Monoclonal; D057134:Antibodies, Neutralizing; D000936:Antigen-Antibody Complex; D053059:Dengue Vaccines; D000939:Epitopes; D014759:Viral Envelope Proteins; D014765:Viral Vaccines