title: [STRUCTURE OF THE SPLEEN AT CHRONIC INTOXICATION OF THE ORGANISM BY SODIUM TETRABORATE AND AFTER INTOXICATION].
abstract: The structure of a spleen of 110 white not purebred rats - males (10 intact, 50 control, 50 experimental) at chronic intoxication by sodium tetraborate and the after intoxication period - the 7, 14, 30 and 60 days were studied. Chronic impact of sodium tetraborate on an organism resulted into increase in the relative weight of a spleen in comparison with body weight that led to increase in weight coefficient of a spleen. Increase in the relative area of all functional zones (periarterial zone, the germinal center, mantle and marginal zones) of lymphoid slug of a white pulp is established. Decrease of an index a red/white pulp, as a result of increase of the area of a white pulp in response to chronic intoxication of an organism is revealed. During the after intoxication period as a result of decrease in immune tension there occured decrease of body weight and decrease in the area of a white pulp. During this period there was a reliable decrease of the area of lymphoid slug and decrease in the area of its functional zones (a periarterial zone, the center of manifolding, mantle and marginal zones).
authors.affiliation: West Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan; I. M. Sechenov First Moscow State Medical University, Moscow, Russia.
authors.forename: T
authors.initials: T
authors.lastname: Umbetov
authors.affiliation: West Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan; I. M. Sechenov First Moscow State Medical University, Moscow, Russia.
authors.forename: A
authors.initials: A
authors.lastname: Berdalinova
authors.affiliation: West Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan; I. M. Sechenov First Moscow State Medical University, Moscow, Russia.
authors.forename: A
authors.initials: A
authors.lastname: Koyshybayev
authors.affiliation: West Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan; I. M. Sechenov First Moscow State Medical University, Moscow, Russia.
authors.forename: K
authors.initials: K
authors.lastname: Umbetova
authors.affiliation: West Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan; I. M. Sechenov First Moscow State Medical University, Moscow, Russia.
authors.forename: G
authors.initials: G
authors.lastname: Sultanova
mesh_terms: D000818:Animals; D001881:Borates / Q000633:toxicity*; D004785:Environmental Pollutants / Q000633:toxicity*; D008297:Male; D051381:Rats; D013154:Spleen / Q000187:drug effects* / Q000473:pathology; D036401:Toxicity Tests, Chronic
chemical_list: D001881:Borates; D004785:Environmental Pollutants; C010634:sodium borate