title: [Prevalence of neuropsychiatric disorders in drug-naive subjects with Parkinson's disease (PD)].
abstract: BACKGROUND
  Parkinson's disease is characterized by a broad spectrum of neuropsychiatric manifestations. Its pathophysiology has been associated with the disease itself as well as with the dopaminergic treatment.
  
  
  METHODS
  A cross-sectional study was conducted in drug-naive patients with early Parkinson's disease. All participants were evaluated through a set of scales for specific neuropsychiatric symptoms including: cognition, depression, anxiety, apathy, psychosis, and impulse control disorder.
  
  
  RESULTS
  A total of 63 patients with Parkinson were included, of whom 26 (41.3%) subjects had some degree of cognitive impairment; seven (11.1%) had depression and 11 (15.8%) subjects had anxiety. Regarding the other symptoms, a total of 12 (19%) patients showed apathy, seven (11.1%) had psychosis, and eight (12.6%) patients had symptoms related to impulse control disorders.
  
  
  CONCLUSIONS
  Neuropsychiatric disorders are common in drug-naive patients with early Parkinson's disease. Given the impact of these symptoms on quality of life, identification and proper treatment is essential.
authors.affiliation: Departamento de Neurología, Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, México.
authors.forename: Sara
authors.initials: S
authors.lastname: Isais-Millán
authors.affiliation: Laboratorio Clínico de Enfermedades Neurodegenerativas, Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, México.
authors.forename: Dan
authors.initials: D
authors.lastname: Piña-Fuentes
authors.affiliation: Departamento de Neurología, Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, México.
authors.forename: Christian
authors.initials: C
authors.lastname: Guzmán-Astorga
authors.affiliation: Laboratorio Clínico de Enfermedades Neurodegenerativas, Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, México.
authors.forename: Amin
authors.initials: A
authors.lastname: Cervantes-Arriaga
authors.affiliation: Laboratorio Clínico de Enfermedades Neurodegenerativas, Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, México.|Clínica de Movimientos Anormales, Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, México.
authors.forename: Mayela
authors.initials: M
authors.lastname: Rodríguez-Violante
mesh_terms: D000368:Aged; D001007:Anxiety / Q000453:epidemiology / Q000209:etiology; D003072:Cognition Disorders / Q000453:epidemiology* / Q000209:etiology; D003430:Cross-Sectional Studies; D003863:Depression / Q000453:epidemiology / Q000209:etiology; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications* / Q000503:physiopathology / Q000523:psychology; D015995:Prevalence; D011618:Psychotic Disorders / Q000453:epidemiology / Q000209:etiology; D011788:Quality of Life