title: [MALLEOLAR ULCERS ASSOCIATED TO HYDROXYUREA TREATMENT].
abstract: BACKGROUND
  Hydroxyurea (HU) is an antineoplastic drug used in chronic myeloproliferative disorders. In this article we will go into detail about the rare but serious appearance of lower limb ulcers in relation to HU treatment.
  
  
  METHODS
  Two simultaneous cases are presented, both from patients with lower limb torpid lesions unresponsive to conventional treatments. After dismissing other aetiologies, HU was found to be the causal agent in both cases.
  
  
  CONCLUSIONS
  In spite of HU's known correlation to lower limb ulcers, pathogenesis isn't clearly defined. In this article we add two more cases to the existing bibliography, with the goal of both insisting on the importance of integral valuation of patients with ulcers and contemplating dermatologic screening on patients treated with HU.
  
  
  CONCLUSIONS
  HU laden ulcers are usually underdiagnosed. Integral valuation and dermatologic screening on patients are critical.
authors.forename: María Auxiliadora
authors.initials: MA
authors.lastname: Aparicio Julián
authors.forename: María Soledad
authors.initials: MS
authors.lastname: Mayorga Baca
authors.forename: Carmen
authors.initials: C
authors.lastname: Morató García
authors.forename: R
authors.initials: R
authors.lastname: Masa Font
authors.forename: Julia María
authors.initials: JM
authors.lastname: Sánchez Schmidt
mesh_terms: D000368:Aged; D000842:Ankle; D005260:Female; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use*; D007871:Leg Ulcer / Q000188:drug therapy*; D008297:Male
chemical_list: D006918:Hydroxyurea