title: [Foetal therapy for Down syndrome: a pro-active ethical reflection].
abstract: Prenatal screening for Down syndrome has to date focused on facilitating the informed choice to continue or not with a pregnancy. The non-invasive prenatal test (NIPT) for Down syndrome does potentially offer the option to apply foetal neurocognitive therapy for Down syndrome (FTDS). Current research in animal models looks promising and therefore a proactive ethical reflection in relation to clinical trials is urgently needed. This discussion includes an exploration of the ethical aspects of FTDS. There seem to be no convincing a priori objections on the basis of the social model of disability. Arguments in terms of (respect for) autonomy, wellbeing and justice seem to in principle support such therapy. Still, both the conditions for sound clinical trials and the implications of possible effective therapy for current prenatal screening need further scrutiny.
authors.affiliation: Universiteit Maastricht, Faculty of Health, Medicine and Life Sciences, afd. Metamedica, onderzoeksscholen CAPHRI en GROW, Maastricht.
authors.forename: G M W R
authors.initials: GM
authors.lastname: de Wert
authors.forename: W J
authors.initials: WJ
authors.lastname: Dondorp
mesh_terms: D004314:Down Syndrome / Q000175:diagnosis / Q000628:therapy*; D004992:Ethics, Medical; D005260:Female; D046128:Fetal Therapies / Q000941:ethics / Q000379:methods*; D005820:Genetic Testing / Q000379:methods; D006801:Humans; D026684:Personal Autonomy; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*