title: The synthesis of functionalized bridged polycycles via C-H bond insertion.
abstract: This review presents examples from the chemical literature of syntheses of bridged-polycyclic products via C-H bond insertion by carbenes and nitrenes. Applications to natural product synthesis, a description of the essential elements in substrate-controlled reactions, and mechanistic details of transformations are presented. Overall, these transformations allow the construction of important ring systems rapidly and efficiently, though additional catalyst development is needed.
authors.affiliation: Department of Chemistry, University of Houston, 3585 Cullen Blvd., Fleming Bldg. Room 112, Houston, TX 77204-5003, United States.
authors.forename: Jiun-Le
authors.initials: JL
authors.lastname: Shih
authors.affiliation: Department of Chemistry, University of Houston, 3585 Cullen Blvd., Fleming Bldg. Room 112, Houston, TX 77204-5003, United States.
authors.forename: Po-An
authors.initials: PA
authors.lastname: Chen
authors.affiliation: Department of Chemistry, University of Houston, 3585 Cullen Blvd., Fleming Bldg. Room 112, Houston, TX 77204-5003, United States.
authors.forename: Jeremy A
authors.initials: JA
authors.lastname: May
keywords: C–H bond insertion; bridged rings; carbene; cascade reaction; nitrene