title: Development of a potential probiotic yoghurt using selected anti-inflammatory lactic acid bacteria for prevention of colitis and carcinogenesis in mice.
abstract: OBJECTIVE
  To evaluate the beneficial properties of a potentially probiotic yoghurt obtained by the fermentation of two selected anti-inflammatory bacterial strains using in vivo mouse models of intestinal inflammation and colon carcinogenesis.
  
  
  RESULTS
  Yoghurt was administered to mice suffering chemically induced intestinal inflammation or colon carcinogenesis. It was shown that this novel yoghurt was able to prevent local inflammation in the intestines of mice through a regulation of the immune response, prevent macroscopic and histological damages, and prevent colon carcinogenesis through an anti-inflammatory response.
  
  
  CONCLUSIONS
  The developed yoghurt showed in vivo anti-inflammatory properties by modulation of the host immune response for the prevention of colon inflammation and carcinogenesis.
  
  
  CONCLUSIONS
  This new yoghurt could thus be considered a probiotic food and be useful as a complement to current treatment protocols for inflammatory bowel diseases and colon cancer, a first since there are no current functional foods specifically oriented for these patients.
authors.affiliation: Centro de Referencia para lactobacilos (CERELA-CONICET), San Miguel de Tucumán, Tucumán, Argentina.
authors.forename: S
authors.initials: S
authors.lastname: Del Carmen
authors.affiliation: Centro de Referencia para lactobacilos (CERELA-CONICET), San Miguel de Tucumán, Tucumán, Argentina.
authors.forename: A
authors.initials: A
authors.lastname: de Moreno de LeBlanc
authors.affiliation: Centro de Referencia para lactobacilos (CERELA-CONICET), San Miguel de Tucumán, Tucumán, Argentina.
authors.forename: J G
authors.identifier: http://orcid.org/0000-0002-4634-8630
authors.initials: JG
authors.lastname: LeBlanc
mesh_terms: D000818:Animals; D063646:Carcinogenesis; D003092:Colitis / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D003110:Colonic Neoplasms / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D005260:Female; D005285:Fermentation; D006801:Humans; D007422:Intestines / Q000276:immunology / Q000382:microbiology; D019344:Lactic Acid / Q000378:metabolism; D007777:Lactobacillaceae / Q000276:immunology / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D019936:Probiotics / Q000008:administration & dosage* / Q000145:classification / Q000302:isolation & purification; D015014:Yogurt / Q000382:microbiology*
chemical_list: D019344:Lactic Acid
keywords: Lactobacillus bulgaricus; Streptococcus thermophilus; carcinogenesis; colitis; lactic acid bacteria