title: ABCC4, ABCC5 and SLC28A1 polymorphisms: host genome on responses of chronic hepatitis B patients with entecavir treatment.
abstract: Nucleoside drug transporter polymorphisms play a significant role in patient responses to drugs. The aim was to investigate the effect of multi-drug resistance protein 4, multi-drug resistance protein 5 and human concentrative nucleoside transporter 1 gene polymorphisms on the response to entecavir treatment in chronic hepatitis B patients.
  
  
  
  A total of 324 chronic HBV treatment-naive Chinese Han patients treated with entecavir 0.5 mg daily for 1 year were enrolled. Patients were divided into a response group and non-response group according to the decline of HBV DNA levels. A multiplex SNaPshot single-base extension method was designed for genotyping.
  
  
  
  The rs3751333GG genotype of multi-drug resistance protein 4 was significantly different between the response group and non-response group at 6 and 12 months (P=0.005 and P=0.019, respectively). Multivariate analysis showed that the rs37751333GG genotype was significantly associated with responses at 6 and 12 months (odds ratio 2.630, 95% CI 1.391, 4.974, P=0.003; odds ratio 2.968, 95% CI 1.416, 6.221, P=0.004).
  
  
  
  The multi-drug resistance protein 4 variant was significantly associated with HBV DNA level suppression in chronic hepatitis B patients treated with entecavir, and therefore, patients with the rs3751333GG genotype might respond better to entecavir in the Chinese Han population.
authors.affiliation: Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.|Division of Infectious Diseases, State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China.
authors.forename: Man
authors.initials: M
authors.lastname: Yuan
authors.affiliation: Department of Gastroenterology, the Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Wenzhen
authors.initials: W
authors.lastname: Wang
authors.affiliation: Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.|Division of Infectious Diseases, State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China.
authors.forename: Han
authors.initials: H
authors.lastname: Chen
authors.affiliation: Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.|Division of Infectious Diseases, State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China.
authors.forename: Jiajie
authors.initials: J
authors.lastname: Lu
authors.affiliation: Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.|Division of Infectious Diseases, State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China.
authors.forename: Min
authors.initials: M
authors.lastname: He
authors.affiliation: Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.|Division of Infectious Diseases, State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China.
authors.forename: Cong
authors.initials: C
authors.lastname: Liu
authors.affiliation: Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.|Division of Infectious Diseases, State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Tang
authors.affiliation: Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.|Division of Infectious Diseases, State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China.
authors.forename: Lichun
authors.initials: L
authors.lastname: Wang
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D005260:Female; D005838:Genotype; D006147:Guanine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D019694:Hepatitis B, Chronic / Q000188:drug therapy* / Q000235:genetics; D006801:Humans; D008297:Male; D026901:Membrane Transport Proteins / Q000235:genetics*; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D000998:Antiviral Agents; D006147:Guanine; D026901:Membrane Transport Proteins; D027425:ATP-Binding Cassette, Sub-Family C Proteins; C073492:ABCC4 protein, human; C120809:ABCC5 protein, human; C065171:cif nucleoside transporter; C413685:entecavir