title: Autotransplantation of pancreatic islets. A single-center first experience.
abstract: BACKGROUND
  Islets auto-transplantation (IAT) is a well-known procedure that may improve glycemic control after total or completion pancreatectomy compared to insulin therapy alone.
  
  
  METHODS
  We herein report our experience in IAT with the case of a sixty years old woman underwent completion pancreatectomy for recurrent pancreatitis. She received IAT by percutaneous trans-hepatic intra-portal injection. The patient recovered well, except for a surgical wound infection that was treated with vacuum therapy. She was discharged on p.o.d. 27th in good general conditions and tolerating a diet.
  
  
  CONCLUSIONS
  Data in literature demonstrate that IAT is cost-effective on the long-run compared to insulin therapy in patients with diabetes. 30-days mortality rate for islets auto-transplantation (IAT) following total pancreatectomy is 5%, which is comparable with previous reports on total pancreatectomy without IAT. Our report may expand the literature on this procedure in order to further develop and improve both technique and outcomes, and clarify the correct indication to surgery.
  
  
  BACKGROUND
  Auto-transplantation, Chronic pancreatitis, IAT, Pancreatic islets, Total pancreatectomy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Magistri
authors.forename: Sara
authors.initials: S
authors.lastname: Andreani
authors.forename: Domenico
authors.initials: D
authors.lastname: Lo Conte
authors.forename: Giovanni Carlo
authors.initials: GC
authors.lastname: Ferrari
authors.forename: Antonello
authors.initials: A
authors.lastname: Forgione
authors.forename: Raffaele
authors.initials: R
authors.lastname: Pugliese
mesh_terms: D003131:Combined Modality Therapy; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000209:etiology / Q000601:surgery*; D005260:Female; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D016381:Islets of Langerhans Transplantation / Q000379:methods*; D008875:Middle Aged; D054843:Negative-Pressure Wound Therapy; D010180:Pancreatectomy / Q000009:adverse effects; D016577:Pancreaticoduodenectomy / Q000009:adverse effects; D050500:Pancreatitis, Chronic / Q000601:surgery; D011183:Postoperative Complications / Q000188:drug therapy / Q000601:surgery*; D012008:Recurrence; D012086:Reoperation; D013530:Surgical Wound Infection / Q000628:therapy; D014182:Transplantation, Autologous
chemical_list: D007328:Insulin