title: Osteoporosis and Impaired Trabecular Bone Score in Hemodialysis Patients.
abstract: OBJECTIVE
  Small attention is paid to other types of bone diseases then chronic kidney disease-mineral and bone disorder in dialysis patients. The aim of our study was to assess the occurrence of osteoporosis and bone microarchitecture by trabecular bone score in this population.
  
  
  METHODS
  59 patients (67.6 ± 13.1 years, 43 males) treated with hemodiafIltration underwent densitometry (Lunar Prodigy, TBS software 2.1.2) and laboratory assessment.
  
  
  RESULTS
  Osteoporosis was observed in 34% patients, high bone turnover was found in 80% of them, with SHPT (PTH > 300 ng/l) present in 69%. TBS was significantly decreased in 47.5% of the patients. TBS correlated with T- and Z-scores of the lumbar spine and proximal femur in the total population (P < 0.0001) and in men (P < 0.00001) and there were significant differences between TBS in groups with normal densitometry, osteopenia, and osteoporosis, both in total population (P < 0.0001; P < 0.01) and in men (P < 0.001; P < 0.001).
  
  
  CONCLUSIONS
  Osteoporosis was found in about 1/3 of patients treated with hemodiafiltration. Normal TBS was found in only 1/4 of the dialysis population. TBS correlated with densitometric parameters and was significantly different relative to T-scores.
authors.affiliation: II. Internal Department, Faculty Hospital Kralovske Vinohrady, and 3rd Faculty of Medicine, Charles University Bone Metabolism Unit, Affidea, Prague, Czech Republic.
authors.forename: Ludmila
authors.initials: L
authors.lastname: Brunerová
authors.forename: Petra
authors.initials: P
authors.lastname: Ronová
authors.forename: Jana
authors.initials: J
authors.lastname: Verešová
authors.forename: Petra
authors.initials: P
authors.lastname: Beranová
authors.forename: Jana
authors.initials: J
authors.lastname: Potoèková
authors.forename: Petr
authors.initials: P
authors.lastname: Kasalický
authors.forename: Ivan
authors.initials: I
authors.lastname: Rychlík
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density; D000071556:Cancellous Bone / Q000473:pathology*; D012080:Chronic Kidney Disease-Mineral and Bone Disorder; D003720:Densitometry; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000150:complications* / Q000473:pathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000453:epidemiology / Q000209:etiology*; D006435:Renal Dialysis