title: Prognostic Value of Major Cardiac Event Risk Score Estimated With Gated Myocardial Perfusion Imaging in Japanese Patients With Coronary Artery Disease.
abstract: We published a cardiac event risk score (CERS) predicting the risk of major cardiac events (MCEs) within 3 years. The purpose of this study was to verify the prognostic value of the CERS before and after treatment in Japanese patients with coronary artery disease.We retrospectively investigated 612 patients who underwent rest (201)Tl and stress (99m)Tc-tetrofosmin myocardial perfusion single photon emission computed tomography (SPECT) between October 2004 and March 2013 and who had a significant stenosis with ≥ 75% narrowing of the arterial diameter detected by coronary angiography performed after confirmation of ≥ 5% ischemia with the SPECT. The patients underwent treatment including revascularization and medication, and thereafter, were re-evaluated with SPECT during a chronic phase and followed-up to confirm prognosis for ≥ 1 year. The endpoint was the onset of MCEs during the follow-up.During the follow-up (36.7 ± 14.5 months), 50 patients (8.7%) experienced MCEs comprising cardiac death (n = 16), non-fatal myocardial infarction (n = 4), and unstable angina pectoris (n = 30). The multivariate Cox proportional hazards regression model analysis for the actual occurrence of MCEs showed the summed difference score % and MCE risks estimated with the CERS after treatment to be significant independent variables. Ischemic reduction after treatment contributed significantly to a decrease in the MCE risks. The MCE risks estimated with the CERS after treatment were generally consistent with the incidence of the MCEs actually observed.The CERS after treatment is a valuable formula for predicting prognosis in Japanese patients with coronary artery disease.
authors.affiliation: Department of Cardiology, Nihon University School of Medicine.
authors.forename: Shunichi
authors.initials: S
authors.lastname: Yoda
authors.forename: Kanae
authors.initials: K
authors.lastname: Nakanishi
authors.forename: Ayako
authors.initials: A
authors.lastname: Tano
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Hori
authors.forename: Misa
authors.initials: M
authors.lastname: Hayase
authors.forename: Takashi
authors.initials: T
authors.lastname: Mineki
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Naoya
authors.initials: N
authors.lastname: Matsumoto
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hirayama
mesh_terms: D003287:Contrast Media / Q000494:pharmacology*; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D005500:Follow-Up Studies; D006801:Humans; D007564:Japan; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D015609:Organotechnetium Compounds / Q000494:pharmacology*; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
chemical_list: D003287:Contrast Media; D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; C078700:technetium tc-99m tetrofosmin