title: The effects of mPEG proportion and LA/GA ratio on degradation and drug release behaviors of PLGA-mPEG microparticles.
abstract: The purpose of this research was to evaluate the effects of mPEG proportion and LA/GA ratio on degradation and release behavior of PLGA-mPEG microparticles prepared by the emulsion evaporation method. Mometasone furoate was employed as model drug and encapsulated into five types of PLGA-mPEG microparticles in the same molecular weight (Mw), but different in mPEG proportion or LA/GA ratio. All types of PLGA-mPEG microparticles showed similar drug encapsulation efficiency and particle mean size, but PLGA-mPEG microparticles with higher mPEG proportion showed a faster Mw reduction rate, mass loss rate and size decrease rate according to the in vitro degradation experiment, and also, a faster drug release rate according to the in vitro release experiment. On the other hand, higher LA/GA ratio in PLGA chain of PLGA-mPEG causes a slower Mw reduction rate, mass loss rate, size decrease rate, and thus, a slower drug release rate.
authors.forename: Chen
authors.initials: C
authors.lastname: Shi
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
authors.forename: Xianzhe
authors.initials: X
authors.lastname: Liu
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Feng
authors.forename: Dehao
authors.initials: D
authors.lastname: Fu
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods; D065546:Drug Liberation; D004655:Emulsions; D008863:Microspheres; D008970:Molecular Weight; D000068656:Mometasone Furoate / Q000008:administration & dosage* / Q000737:chemistry; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004655:Emulsions; D011091:Polyesters; C558447:methoxypolyethyleneglycol-poly(lactic-co-glycolic acid); D000068656:Mometasone Furoate; D011092:Polyethylene Glycols