title: Neoadjuvant Intraarterial Chemotherapy for Treatment of Malignant Vaginal Tumors in Children: A Single-Center Experience.
abstract: Six patients (aged 3-36 mo) with vaginal tumors (rhabdomyosarcoma and endodermal sinus tumor [EST]; n = 3 each) received intraarterial chemotherapy (IAC) and intravenous chemotherapy. Patients underwent internal iliac artery infusion with cisplatin, pirarubicin, and vindesine. Intravenous chemotherapy with vindesine, ifosfamide, and etoposide was administered after 3 weeks. Vaginal tumors disappeared in all patients after 2 or 3 cycles of alternating therapy. Two patients underwent resection of pelvic metastases. Intravenous consolidation chemotherapy was applied. Four patients were disease-free at a median follow-up of 5.8 years. One patient had pelvic recurrence treated with "salvage" therapy with IAC and surgery and was disease-free for 2.5 years.
authors.affiliation: Divisions of Pediatric Urology, Children's Hospital, Zhejiang University School of Medicine, Zhugan Xiang 57, Hangzhou 310003, China; Department of Pediatric Surgery, Children's Hospital, Zhejiang University School of Medicine, Zhugan Xiang 57, Hangzhou 310003, China.
authors.forename: De-Hua
authors.initials: DH
authors.lastname: Wu
authors.affiliation: Department of Pediatric Surgery, Children's Hospital, Zhejiang University School of Medicine, Zhugan Xiang 57, Hangzhou 310003, China. Electronic address: minjuli@qq.com.
authors.forename: Min-Ju
authors.initials: MJ
authors.lastname: Li
authors.affiliation: Divisions of Pediatric Urology, Children's Hospital, Zhejiang University School of Medicine, Zhugan Xiang 57, Hangzhou 310003, China; Department of Pediatric Surgery, Children's Hospital, Zhejiang University School of Medicine, Zhugan Xiang 57, Hangzhou 310003, China.
authors.forename: Da-Xing
authors.initials: DX
authors.lastname: Tang
authors.affiliation: Divisions of Pediatric Urology, Children's Hospital, Zhejiang University School of Medicine, Zhugan Xiang 57, Hangzhou 310003, China; Department of Pediatric Surgery, Children's Hospital, Zhejiang University School of Medicine, Zhugan Xiang 57, Hangzhou 310003, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Xu
authors.affiliation: Divisions of Pediatric Urology, Children's Hospital, Zhejiang University School of Medicine, Zhugan Xiang 57, Hangzhou 310003, China; Department of Pediatric Surgery, Children's Hospital, Zhejiang University School of Medicine, Zhugan Xiang 57, Hangzhou 310003, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Pediatric Surgical Oncology, Children's Hospital, Zhejiang University School of Medicine, Zhugan Xiang 57, Hangzhou 310003, China; Department of Pediatric Surgery, Children's Hospital, Zhejiang University School of Medicine, Zhugan Xiang 57, Hangzhou 310003, China.
authors.forename: Jin-Hu
authors.initials: JH
authors.lastname: Wang
authors.affiliation: Pediatric Surgery, Children's Hospital, Zhejiang University School of Medicine, Zhugan Xiang 57, Hangzhou 310003, China; Department of Pediatric Surgery, Children's Hospital, Zhejiang University School of Medicine, Zhugan Xiang 57, Hangzhou 310003, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Shu
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000009:adverse effects; D001706:Biopsy; D002675:Child, Preschool; D002681:China; D002945:Cisplatin / Q000008:administration & dosage; D018572:Disease-Free Survival; D004317:Doxorubicin / Q000008:administration & dosage / Q000031:analogs & derivatives; D004334:Drug Administration Schedule; D018240:Endodermal Sinus Tumor / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D007083:Iliac Artery; D007223:Infant; D007261:Infusions, Intra-Arterial; D007262:Infusions, Intravenous; D059146:Metastasectomy; D020360:Neoadjuvant Therapy; D010386:Pelvic Neoplasms / Q000188:drug therapy / Q000556:secondary / Q000601:surgery; D012189:Retrospective Studies; D018233:Rhabdomyosarcoma, Embryonal / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014625:Vaginal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D014751:Vindesine / Q000008:administration & dosage
chemical_list: D005047:Etoposide; D004317:Doxorubicin; C027260:pirarubicin; D002945:Cisplatin; D014751:Vindesine; D007069:Ifosfamide