title: Acute ST elevation myocardial infarction in fulminant systemic p-ANCA vasculitis: a rare catastrophic complication.
abstract: A 45-year-old Caucasian man presented to the hospital with a 3-month history of fatigue, bilateral upper and lower limb paresthesias and gradually worsening ascending paralysis. A few weeks later, he developed acute renal failure requiring haemodialysis. Investigations revealed presence of myeloperoxidase (MPO) perinuclear antineutrophil cytoplasmic antibodies (ANCA). Renal biopsy was conclusive for rapidly progressive glomerulonephritis with crescents. Treatment for ANCA positive vasculitis was initiated with pulsed steroids, cyclophosphamide and plasmapheresis. The hospital course took an unexpected turn when the patient developed acute chest pain with an EKG consistent with inferior ST elevation myocardial infarction (STEMI). Urgent left heart catheterisation revealed distal occlusions in multivessel coronary distribution. Coronary involvement is rare in ANCA vasculitis and STEMI has not been reported in MPO-ANCA positive vasculitis, to the best of our knowledge.
authors.affiliation: Department of Internal Medicine, LSU Health Sciences Center-Shreveport, Shreveport, Louisiana, USA.
authors.forename: Kanupriya
authors.initials: K
authors.lastname: Mathur
authors.affiliation: Department of Medicine/Section of Cardiology, LSU Health Sciences Center-Shreveport, Shreveport, Louisiana, USA.
authors.forename: Aditya
authors.initials: A
authors.lastname: Saini
authors.affiliation: Department of Medicine-Pediatrics, LSU Health Sciences Center-Shreveport, Shreveport, Louisiana, USA.
authors.forename: Tonjeh
authors.initials: T
authors.lastname: Bah
authors.affiliation: Department of Medicine/Section of Cardiology, LSU Health Sciences Center-Shreveport, Shreveport, Louisiana, USA.
authors.forename: Pavan
authors.initials: P
authors.lastname: Katikaneni
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic / Q000378:metabolism*; D017023:Coronary Angiography; D054059:Coronary Occlusion / Q000000981:diagnostic imaging / Q000209:etiology; D005921:Glomerulonephritis / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D018763:Muscle Fatigue / Q000502:physiology; D010243:Paralysis / Q000209:etiology; D010292:Paresthesia / Q000209:etiology; D009195:Peroxidase / Q000378:metabolism; D000072657:ST Elevation Myocardial Infarction / Q000000981:diagnostic imaging / Q000209:etiology*; D056647:Systemic Vasculitis / Q000150:complications* / Q000000981:diagnostic imaging; D016896:Treatment Outcome
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D009195:Peroxidase