title: Effect of HIV Infection on Human Papillomavirus Types Causing Invasive Cervical Cancer in Africa.
abstract: HIV infection is known to worsen the outcome of cervical human papillomavirus (HPV) infection and may do so differentially by HPV type.
  
  
  
  Twenty-one studies were included in a meta-analysis of invasive cervical cancers (ICC) among women infected with HIV in Africa.
  
  
  
  Type-specific HPV DNA prevalence was compared with data from a similar meta-analysis of HIV-negative ICC using prevalence ratios (PR).
  
  
  
  HPV detection was similar in 770 HIV-positive (91.2%) and 3846 HIV-negative (89.6%) ICC, but HIV-positive ICC harbored significantly more multiple HPV infections (PR = 1.75, 95% confidence intervals: 1.18 to 2.58), which were significantly more prevalent in ICC tested from cells than from biopsies. HPV16 was the most frequently detected type in HIV-positive ICC (42.5%), followed by HPV18 (22.2%), HPV45 (14.4%), and HPV35 (7.1%). Nevertheless, HIV-positive ICC were significantly less frequently infected with HPV16 than HIV-negative ICC (PR = 0.88, 95% confidence intervals: 0.79 to 0.99). Other high-risk types were significantly more prevalent in HIV-positive ICC, but only for HPV18 was there a significantly higher prevalence of both single and multiple infections in HIV-positive ICC. Increases for other high-risk types were primarily accounted for by multiple infections. The proportion of HPV-positive ICC estimated attributable to HPV16/18 (71.8% in HIV positive, 73.4% in HIV negative) or HPV16/18/31/33/45/52/58 (88.8%, 89.5%) was not affected by HIV.
  
  
  
  HIV alters the relative carcinogenicity of HPV types, but prophylactic HPV16/18 vaccines may nevertheless prevent a similar proportion of ICC, irrespective of HIV infection.
authors.affiliation: International Agency for Research on Cancer, Lyon, France.
authors.forename: Gary M
authors.initials: GM
authors.lastname: Clifford
authors.forename: Hugo
authors.initials: H
authors.lastname: de Vuyst
authors.forename: Vanessa
authors.initials: V
authors.lastname: Tenet
authors.forename: Martyn
authors.initials: M
authors.lastname: Plummer
authors.forename: Stephen
authors.initials: S
authors.lastname: Tully
authors.forename: Silvia
authors.initials: S
authors.lastname: Franceschi
mesh_terms: D000349:Africa / Q000453:epidemiology; D002584:Cervix Uteri / Q000821:virology; D004279:DNA, Viral; D005260:Female; D015658:HIV Infections / Q000453:epidemiology*; D006679:HIV Seropositivity / Q000453:epidemiology; D061809:Human Papillomavirus DNA Tests; D052162:Human papillomavirus 16 / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D052161:Human papillomavirus 18 / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D006801:Humans; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000473:pathology / Q000821:virology*; D015995:Prevalence; D011379:Prognosis; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000821:virology*
chemical_list: D004279:DNA, Viral