title: Synthesis of Functionalized Pyridines via a Regioselective Oxazoline Promoted C-H Amidation Reaction.
abstract: The first Rh-catalyzed C-H amidation of pyridines is reported. The incorporation of a substituent at the C2 position both is crucial to the success of this transformation and provides considerable scope for further elaboration of the resulting products. Among these compounds, 2-chloropyridines allow access to a selection of intermediates including a versatile azaquinazoline scaffold.
authors.affiliation: Department of Chemistry, University of Sheffield , Sheffield, S3 7HF, U.K.
authors.forename: Tracy M M
authors.initials: TM
authors.lastname: Maiden
authors.affiliation: GlaxoSmithKline, Stevenage, Hertfordshire, SG1 2NY, U.K.
authors.forename: Stephen
authors.initials: S
authors.lastname: Swanson
authors.affiliation: GlaxoSmithKline, Stevenage, Hertfordshire, SG1 2NY, U.K.
authors.forename: Panayiotis A
authors.initials: PA
authors.lastname: Procopiou
authors.affiliation: Department of Chemistry, University of Sheffield , Sheffield, S3 7HF, U.K.
authors.forename: Joseph P A
authors.initials: JP
authors.lastname: Harrity