title: ROS and Brain Gliomas: An Overview of Potential and Innovative Therapeutic Strategies.
abstract: Reactive oxygen species (ROS) represent reactive products belonging to the partial reduction of oxygen. It has been reported that ROS are involved in different signaling pathways to control cellular stability. Under normal conditions, the correct function of redox systems leads to the prevention of cell oxidative damage. When ROS exceed the antioxidant defense system, cellular stress occurs. The cellular redox impairment is strictly related to tumorigenesis. Tumor cells, through the generation of hydrogen peroxide, tend to the alteration of cell cycle phases and, finally to cancer progression. In adults, the most common form of primary malignant brain tumors is represented by gliomas. The gliomagenesis is characterized by numerous molecular processes all characterized by an altered production of growth factor receptors. The difficulty to treat brain cancer depends on several biological mechanisms such as failure of drug delivery through the blood-brain barrier, tumor response to chemotherapy, and intrinsic resistance of tumor cells. Understanding the mechanisms of ROS action could allow the formulation of new therapeutic protocols to treat brain gliomas.
authors.affiliation: Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy. mrinaldi@unime.it.
authors.forename: Mariagrazia
authors.initials: M
authors.lastname: Rinaldi
authors.affiliation: Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Neurosurgical Clinic, University of Messina, 98125 Messina, Italy. mcaffo@unime.it.
authors.forename: Maria
authors.initials: M
authors.lastname: Caffo
authors.affiliation: Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy. lminutoli@unime.it.
authors.forename: Letteria
authors.initials: L
authors.lastname: Minutoli
authors.affiliation: Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy. hrmarini@unime.it.
authors.forename: Herbert
authors.initials: H
authors.lastname: Marini
authors.affiliation: Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Neurosurgical Clinic, University of Messina, 98125 Messina, Italy. rv.abbritti@hotmail.it.
authors.forename: Rosaria Viola
authors.initials: RV
authors.lastname: Abbritti
authors.affiliation: Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy. fsquadrito@unime.it.
authors.forename: Francesco
authors.initials: F
authors.lastname: Squadrito
authors.affiliation: Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy. vtrichilo@unime.it.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Trichilo
authors.affiliation: Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy. avalenti@unime.it.
authors.forename: Andrea
authors.initials: A
authors.lastname: Valenti
authors.affiliation: Department of Human Pathology, University of Messina, 98125 Messina, Italy. vbarresi@unime.it.
authors.forename: Valeria
authors.initials: V
authors.lastname: Barresi
authors.affiliation: Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Neurosurgical Clinic, University of Messina, 98125 Messina, Italy. daltavilla@unime.it.
authors.forename: Domenica
authors.initials: D
authors.lastname: Altavilla
authors.affiliation: Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Neurosurgical Clinic, University of Messina, 98125 Messina, Italy. mpassalacqua@unime.it.
authors.forename: Marcello
authors.initials: M
authors.lastname: Passalacqua
authors.affiliation: Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Neurosurgical Clinic, University of Messina, 98125 Messina, Italy. gcaruso@unime.it.
authors.forename: Gerardo
authors.initials: G
authors.lastname: Caruso
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use; D000975:Antioxidants / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use; D001812:Blood-Brain Barrier / Q000378:metabolism; D001932:Brain Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D019008:Drug Resistance, Neoplasm; D005910:Glioma / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D017382:Reactive Oxygen Species / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D017382:Reactive Oxygen Species
keywords: blood-brain barrier; glioma; reactive oxygen species (ROS); therapeutic strategy; tumor growth