title: Comparative efficacy and safety of axitinib versus sorafenib in metastatic renal cell carcinoma: a systematic review and meta-analysis.
abstract: OBJECTIVE
  This study was performed to evaluate the comparative efficacy and safety of axitinib and sorafenib in the therapy of metastatic renal cell carcinoma.
  
  
  METHODS
  Eligible studies were searched from PubMed, Embase, and Future Medicine databases. The pooled hazard ratios and relative risk ratios (RRs) were calculated by using Stata 12.0 software.
  
  
  RESULTS
  A total of 1,011 patients qualified to participate in this Phase III study that included randomized controlled trials. Meta-analysis results showed that axitinib was more highly and significantly associated with a survival benefit in the independently assessed progression-free survival in comparison to sorafenib. The values of RR of the objective response rate and disease control rate were also significantly different. Results of the analysis of adverse events concerning hypertension and hypothyroidism demonstrated that the values of RR were significantly higher in the axitinib group and lower risks were established in the patients treated with axitinib.
  
  
  CONCLUSIONS
  Therefore, axitinib was a better treatment option for metastatic renal cell carcinoma treatment than sorafenib, especially after failure of prior systemic therapies. This analysis revealed that axitinib had higher risks of hypertension and hypothyroidism and lower risks of rash and palmar-plantar erythrodysesthesia.
authors.affiliation: Department of Urology, Beijing Jishuitan Hospital, Beijing, People's Republic of China.
authors.forename: Hai
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Urology, Beijing Jishuitan Hospital, Beijing, People's Republic of China.
authors.forename: Libo
authors.initials: L
authors.lastname: Man
authors.affiliation: Department of Urology, Beijing Jishuitan Hospital, Beijing, People's Republic of China.
authors.forename: Guizhong
authors.initials: G
authors.lastname: Li
authors.affiliation: Department of Urology, Beijing Jishuitan Hospital, Beijing, People's Republic of China.
authors.forename: Guanglin
authors.initials: G
authors.lastname: Huang
authors.affiliation: Department of Urology, Beijing Jishuitan Hospital, Beijing, People's Republic of China.
authors.forename: Jianwei
authors.initials: J
authors.lastname: Wang
keywords: adverse events; axitinib; efficacy; metastatic renal cell carcinoma; phase III study; progression-free survival; sorafenib