title: Long-term cancer-related fatigue outcomes in patients with locally advanced prostate cancer after intensity-modulated radiotherapy combined with hormonal therapy.
abstract: The aim of our study was to investigate the relationship between cancer-related fatigue and clinical parameters, and the effect factors of fatigue for the prostate cancer patients. Long-term follow-up is performed using the Fatigue Symptom Inventory before treatment (A), at the end of intensity-modulated radiotherapy (B), and 3 months (C), 12 months (D), 24 months (E), 36 months (F), and 48 months (G) after the end of intensity-modulated radiotherapy. Three dimensions of fatigue are assessed during follow-up: severity, perceived interference with quality of life, and duration in the past week. In all, 97 patients with locally advanced prostate cancer were enrolled in the study. Median follow-up time was 43.9 months. The fatigue index was significantly higher in the prostate-specific antigen >20 ng/mL, Gleason score >8, the Eastern Cooperative Oncology Group scores, and the higher education. The most severe fatigue occurred at time points B and C. The score for duration of fatigue fluctuated across the time points, with significantly increased scores at time points D, E, and F.In conclusion, we show that cancer-related fatigue is the important symptom which affects the quality of life for the prostate cancer patients. For patients with locally advanced prostate cancer with a high Eastern Cooperative Oncology Group score, a Gleason score of >8 points, prostate-specific antigen levels of >20 ng/mL, and high education, attention should be paid to the interference of fatigue with quality of life, especially general level of activity, ability to concentrate, and mood, after radiotherapy combined with hormonal therapy.
authors.affiliation: Department of Radiation Oncology, FuZhou General Hospital of NanJing Command PLA, FuZhou Department of Medical, FuZhou General Hospital of NanJing Command PLA, FuZhou Department of Mendicine, LongYan Hospital of Tradiational Chinese Medicine, LongYang Department of Radiation Oncology, FuJian Province Hospital, FuZhou Department of Rrology, JinJiang Hospital, QuanZhou, China Department of Radiation Oncology, Rush University Medical Center, Chicago, IL.
authors.forename: Hua-Chun
authors.initials: HC
authors.lastname: Luo
authors.forename: Yong
authors.initials: Y
authors.lastname: Lei
authors.forename: Hui-Hua
authors.initials: HH
authors.lastname: Cheng
authors.forename: Zhi-Chao
authors.initials: ZC
authors.lastname: Fu
authors.forename: Shao-Guang
authors.initials: SG
authors.lastname: Liao
authors.forename: Jing
authors.initials: J
authors.lastname: Feng
authors.forename: Qin
authors.initials: Q
authors.lastname: Yin
authors.forename: Qun-Hua
authors.initials: QH
authors.lastname: Chen
authors.forename: Gui-Shan
authors.initials: GS
authors.lastname: Lin
authors.forename: Jin-Feng
authors.initials: JF
authors.lastname: Zhu
authors.forename: Jian-Feng
authors.initials: JF
authors.lastname: Xu
authors.forename: Dian
authors.initials: D
authors.lastname: Wang
mesh_terms: D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D005221:Fatigue / Q000209:etiology*; D005500:Follow-Up Studies; D017273:Goserelin / Q000008:administration & dosage*; D006801:Humans; D007279:Injections, Subcutaneous; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011471:Prostatic Neoplasms / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D011788:Quality of Life; D011879:Radiotherapy Dosage; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods*; D012189:Retrospective Studies; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D018931:Antineoplastic Agents, Hormonal; D017273:Goserelin