title: Neutralizing capacity of inhibitors on FVIII is lower for natural FVIII/VWF complex than for isolated FVIII: in vitro comparative study in eleven different therapeutic FVIII concentrates.
authors.affiliation: Research & Development, Bioscience Industrial Group, Grifols, Barcelona, Spain.
authors.forename: M I
authors.initials: MI
authors.lastname: Bravo
authors.affiliation: Research & Development, Bioscience Industrial Group, Grifols, Barcelona, Spain.
authors.forename: A M
authors.initials: AM
authors.lastname: Ortiz
authors.affiliation: Research & Development, Bioscience Industrial Group, Grifols, Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Costa
authors.affiliation: Research & Development, Bioscience Industrial Group, Grifols, Barcelona, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Grancha
authors.affiliation: Research & Development, Bioscience Industrial Group, Grifols, Barcelona, Spain.
authors.forename: J I
authors.initials: JI
authors.lastname: Jorquera
mesh_terms: D057134:Antibodies, Neutralizing / Q000097:blood / Q000276:immunology*; D003029:Coagulants / Q000276:immunology* / Q000627:therapeutic use; D004338:Drug Combinations; D005169:Factor VIII / Q000235:genetics / Q000276:immunology* / Q000627:therapeutic use; D006467:Hemophilia A / Q000188:drug therapy; D006801:Humans; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000276:immunology / Q000627:therapeutic use; D014841:von Willebrand Factor / Q000276:immunology* / Q000627:therapeutic use
chemical_list: D057134:Antibodies, Neutralizing; D003029:Coagulants; D004338:Drug Combinations; D011994:Recombinant Proteins; C509423:factor VIII, von Willebrand factor drug combination; D014841:von Willebrand Factor; D005169:Factor VIII
keywords: FVIII inhibitors; FVIII/VWF complex; chromogenic assay; factor VIII; von Willebrand factor