title: Muraymycin nucleoside-peptide antibiotics: uridine-derived natural products as lead structures for the development of novel antibacterial agents.
abstract: Muraymycins are a promising class of antimicrobial natural products. These uridine-derived nucleoside-peptide antibiotics inhibit the bacterial membrane protein translocase I (MraY), a key enzyme in the intracellular part of peptidoglycan biosynthesis. This review describes the structures of naturally occurring muraymycins, their mode of action, synthetic access to muraymycins and their analogues, some structure-activity relationship (SAR) studies and first insights into muraymycin biosynthesis. It therefore provides an overview on the current state of research, as well as an outlook on possible future developments in this field.
authors.affiliation: Department of Pharmacy, Pharmaceutical and Medicinal Chemistry, Saarland University, Campus C2 3, 66123 Saarbruecken, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Wiegmann
authors.affiliation: Department of Pharmacy, Pharmaceutical and Medicinal Chemistry, Saarland University, Campus C2 3, 66123 Saarbruecken, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Koppermann
authors.affiliation: Department of Pharmacy, Pharmaceutical and Medicinal Chemistry, Saarland University, Campus C2 3, 66123 Saarbruecken, Germany.
authors.forename: Marius
authors.initials: M
authors.lastname: Wirth
authors.affiliation: Department of Pharmacy, Pharmaceutical and Medicinal Chemistry, Saarland University, Campus C2 3, 66123 Saarbruecken, Germany.
authors.forename: Giuliana
authors.initials: G
authors.lastname: Niro
authors.affiliation: Department of Pharmacy, Pharmaceutical and Medicinal Chemistry, Saarland University, Campus C2 3, 66123 Saarbruecken, Germany.
authors.forename: Kristin
authors.initials: K
authors.lastname: Leyerer
authors.affiliation: Department of Pharmacy, Pharmaceutical and Medicinal Chemistry, Saarland University, Campus C2 3, 66123 Saarbruecken, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Ducho
keywords: antibiotics; natural products; nucleosides; peptides; structure–activity relationship