title: Stereoselective synthesis and antitumoral activity of Z-enyne pseudoglycosides.
abstract: An efficient approach for the synthesis of Z-1,3-enynes based on the coupling reaction of Z-vinyl tellurides and alkynes containing a pseudoglycoside moiety is described. The products were obtained in good yields via a stereoselective way. Preliminary screening against three tumor cell lines indicated that the synthesized compounds are promising intermediates for the synthesis of an array of more potent target structures.
authors.affiliation: UFRPE, Depto. Química, Recife, PE, Brazil.
authors.forename: Claudio R
authors.initials: CR
authors.lastname: Dantas
authors.affiliation: UFPE, Depto. Química Fundamental, Recife, PE, Brazil. paulo.menezes@pq.cnpq.br.
authors.forename: Jucleiton J R
authors.initials: JJ
authors.lastname: de Freitas
authors.affiliation: UFPE, Depto. Química Fundamental, Recife, PE, Brazil. paulo.menezes@pq.cnpq.br.
authors.forename: Queila P S
authors.initials: QP
authors.lastname: Barbosa
authors.affiliation: UFPE - Depto. Fisiologia e Farmacologia, Recife, PE, Brazil.
authors.forename: Gardenia C G
authors.initials: GC
authors.lastname: Militão
authors.affiliation: UFPE - Depto. Fisiologia e Farmacologia, Recife, PE, Brazil.
authors.forename: Thiago D S
authors.initials: TD
authors.lastname: Silva
authors.affiliation: UFPE - Depto. de Antibióticos, Recife, PE, Brazil.
authors.forename: Teresinha G
authors.initials: TG
authors.lastname: da Silva
authors.affiliation: USP - Instituto de Química, São Paulo, SP, Brazil.
authors.forename: Antônio A S
authors.initials: AA
authors.lastname: Paulino
authors.affiliation: UFRPE, Depto. Química, Recife, PE, Brazil and UFCG - Centro de Educação e Saúde, Cuité, PB, Brazil.
authors.forename: Juliano C R
authors.initials: JC
authors.lastname: Freitas
authors.affiliation: UFPE, Depto. Química Fundamental, Recife, PE, Brazil. paulo.menezes@pq.cnpq.br.
authors.forename: Roberta A
authors.initials: RA
authors.lastname: Oliveira
authors.affiliation: UFPE, Depto. Química Fundamental, Recife, PE, Brazil. paulo.menezes@pq.cnpq.br.
authors.forename: Paulo H
authors.initials: PH
authors.lastname: Menezes
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D006027:Glycosides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D013237:Stereoisomerism; D013691:Tellurium / Q000737:chemistry* / Q000494:pharmacology; D014753:Vinyl Compounds / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000480:Alkynes; D000970:Antineoplastic Agents; D006027:Glycosides; D014753:Vinyl Compounds; D013691:Tellurium