title: Evaluating -238 G>A Polymorphism Association in TNF-α Gene with Metabolic Parameters and Nutritional Intakes Among the Iranian NAFLD Patients.
abstract: Different studies have shown that -238 G>A polymorphism in promoter region of tumor necrosis factor alpha (TNF-α) gene is associated with increased risk of non-alcoholic fatty liver disease (NAFLD). The current study investigates the association between metabolic parameters and nutritional intakes with -238 G>A of TNF-α promoter gene polymorphism among the Iranian patients with NAFLD. In this study, 75 patients with NAFLD and 76 individuals as control were enrolled. Dietary intakes were assessed using a semi-quantitative food-frequency questionnaire. Body mass index and waist to hip ratio were calculated. Biochemical assays were measured after 12 h fasting. -238 G>A Polymorphism of TNF-α gene was determined by using sequencing method. We observed no significant difference in frequency of different genotypes of this polymorphism between NAFLD and control groups (P > 0.05). Among biochemical parameters, TAC showed significant decrease in NAFLD patients with GG genotype when compared to controls (P = 0.001). The comparison of macro and micronutrient intakes between groups according to genotypes showed no statistically significant difference (P > 0.05). Although the data were not statistically significant, further studies with larger sample size are needed to determine the effect of dietary compounds in NAFLD.
authors.affiliation: Nutrition Research Center, School of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.|Cellular and Molecular Research Centre, Qazvin University of Medical Sciences, P.O. Box 341197-5981, Qazvin, Iran.
authors.forename: F
authors.initials: F
authors.lastname: Mohseni
authors.affiliation: Cellular and Molecular Research Centre, Qazvin University of Medical Sciences, P.O. Box 341197-5981, Qazvin, Iran.
authors.forename: Z
authors.initials: Z
authors.lastname: Rashvand
authors.affiliation: Cellular and Molecular Research Centre, Qazvin University of Medical Sciences, P.O. Box 341197-5981, Qazvin, Iran.
authors.forename: R
authors.initials: R
authors.lastname: Najafipour
authors.affiliation: Nutrition Research Center, School of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Sh
authors.initials: Sh
authors.lastname: Hadizadeh
authors.affiliation: Cellular and Molecular Research Centre, Qazvin University of Medical Sciences, P.O. Box 341197-5981, Qazvin, Iran. smoghbelinejad@qums.ac.ir.
authors.forename: S
authors.initials: S
authors.lastname: Moghbelinejad
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000032:analysis; D004435:Eating; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000235:genetics* / Q000378:metabolism*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D044465:White People / Q000235:genetics*; D055815:Young Adult
chemical_list: D000975:Antioxidants; C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha
keywords: Biochemical parameters; Non-alcoholic fatty liver disease (NAFLD); Nutrition; TNF-α gene; −238 G>A polymorphism