title: Avoiding hepatic metastasis naturally: Lessons from the cotton top tamarin (Saguinus oedipus).
abstract: Much has been written about hepatic metastasis and animal models abound. In terms of the human experience, progress in treating this final common pathway, a terminal event of many human malignancies has been relatively slow. The current thinking is that primary prevention is best served by early detection of cancer and eradication of early stage cancers by screening. Some cancers spread early in their course and the role of screening may be limited. Until relatively recently there has not been a pathfinder model that makes the evasion of this unfortunate event a reality. This review discusses such an animal model and attempts to relate it to human disease in terms of intervention. Concrete proposals are also offered on how scientists may be able to intervene to prevent this deadly progression of the cancer process.
authors.affiliation: Martin Tobi, Department of Surgery, Aleda E. Lutz VAMC, Saginaw, MI 48601, United States.
authors.forename: Martin
authors.initials: M
authors.lastname: Tobi
authors.affiliation: Martin Tobi, Department of Surgery, Aleda E. Lutz VAMC, Saginaw, MI 48601, United States.
authors.forename: Peter
authors.initials: P
authors.lastname: Thomas
authors.affiliation: Martin Tobi, Department of Surgery, Aleda E. Lutz VAMC, Saginaw, MI 48601, United States.
authors.forename: Daniel
authors.initials: D
authors.lastname: Ezekwudo
mesh_terms: D000818:Animals; D023102:Anoikis; D002272:Carcinoembryonic Antigen / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000473:pathology*; D004195:Disease Models, Animal; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D008113:Liver Neoplasms / Q000378:metabolism / Q000517:prevention & control / Q000556:secondary*; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D012452:Saguinus
chemical_list: D002272:Carcinoembryonic Antigen; D015815:Cell Adhesion Molecules; D016326:Extracellular Matrix Proteins; D011956:Receptors, Cell Surface
keywords: Carcinoembryonic antigen; Common marmoset; Cotton top tamarin; Fibulin-5; Hepatic metastasis