title: Nab-paclitaxel plus gemcitabine as first-line palliative chemotherapy in a patient with metastatic pancreatic cancer with Eastern Cooperative Oncology Group performance status of 2.
abstract: Metastatic pancreatic cancer (PC) has been associated with a considerably poor prognosis. Due to its toxicity, first-line combination chemotherapy is limited to patients with a good performance status (PS). Previously nab-paclitaxel plus gemcitabine has been demonstrated to improve the overall survival rate in patients with advanced pancreatic cancer with a good PS. The present study reports a case of a patient with metastatic PC with a poor PS (Eastern Cooperative Oncology Group 2) and a complex set of comorbidities treated with nab-paclitaxel plus gemcitabine as a first-line palliative therapy. Adjusted doses of nab-paclitaxel plus gemcitabine reached a favourable clinical, radiological and biochemical response in the present patient, which increased the quality of life for the patient. Eventually, the patient succumbed to acute cholangitis. Based on the results of the present study, nab-paclitaxel plus gemcitabine appears to be a favourable treatment as first-line palliative chemotherapy for patients with metastatic PC, comorbidities and poor PS.
authors.affiliation: Medical Oncology Service, Hospital General Universitario Gregorio Marañón, Madrid 28007, Spain.
authors.forename: Andrés J Muñoz
authors.initials: AJ
authors.lastname: Martín
authors.affiliation: Medical Oncology Service, Hospital General Universitario Gregorio Marañón, Madrid 28007, Spain.
authors.forename: Pilar García
authors.initials: PG
authors.lastname: Alfonso
authors.affiliation: Medical Oncology Service, Hospital General Universitario Gregorio Marañón, Madrid 28007, Spain.
authors.forename: Ana B
authors.initials: AB
authors.lastname: Rupérez
authors.affiliation: Medical Oncology Service, Hospital General Universitario Gregorio Marañón, Madrid 28007, Spain.
authors.forename: Miguel Martín
authors.initials: MM
authors.lastname: Jiménez
keywords: CA19-9; nab-paclitaxel plus gemcitabine; palliative therapy; pancreatic adenocarcinoma; poor performance status; tolerance