title: Association of B12 deficiency and anemia synergistically increases the risk of high TNF-α levels among adolescent girls.
abstract: We investigated the association between iron status, B12, and inflammatory markers among 101 adolescent girls. We found that B12 showed significant negative association with tumor necrosis factor-alpha (TNF-α) (rs = -0.232, P = 0.020) and positive association with serum ferritin (SF) (rs = 0.209, P = 0.036) among girls. Our results showed that hepcidin discriminates anemic and non-anemic population under normal B12 conditions. The logistic regression analysis revealed that the risk of having higher TNF-α levels was 13.2 times higher in low B12 girls in the presence of anemia compared to the girls having normal hemoglobin and B12 levels.
authors.affiliation: Bioprospecting Group, Agharkar Research Institute, Pune, 411004, India. kulkarniari@gmail.com.
authors.forename: N S
authors.initials: NS
authors.lastname: Ghatpande
authors.affiliation: Bioprospecting Group, Agharkar Research Institute, Pune, 411004, India. kulkarniari@gmail.com.
authors.forename: P P
authors.initials: PP
authors.lastname: Apte
authors.affiliation: K. E. M. Hospital and Research Center, Pune, 411011, India.
authors.forename: S S
authors.initials: SS
authors.lastname: Naik
authors.affiliation: Bioprospecting Group, Agharkar Research Institute, Pune, 411004, India. kulkarniari@gmail.com.
authors.forename: B N
authors.initials: BN
authors.lastname: Joshi
authors.affiliation: Bioprospecting Group, Agharkar Research Institute, Pune, 411004, India. kulkarniari@gmail.com.
authors.forename: M K
authors.initials: MK
authors.lastname: Gokhale
authors.affiliation: Bioprospecting Group, Agharkar Research Institute, Pune, 411004, India. kulkarniari@gmail.com.
authors.forename: P P
authors.initials: PP
authors.lastname: Kulkarni
mesh_terms: D000293:Adolescent; D000740:Anemia / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D005260:Female; D005293:Ferritins / Q000097:blood; D006454:Hemoglobins / Q000378:metabolism; D064451:Hepcidins / Q000097:blood; D006801:Humans; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*; D014806:Vitamin B 12 Deficiency / Q000097:blood* / Q000150:complications / Q000503:physiopathology
chemical_list: D006454:Hemoglobins; D064451:Hepcidins; D014409:Tumor Necrosis Factor-alpha; D005293:Ferritins