title: Relative potency of tyrosol in the treatment of endotoxin-induced uveitis in rats.
abstract: Tyrosol (Tyr) is a natural phenolic antioxidant with diverse biological activities. We compared the anti-inflammatory effects of intravenously administered Tyr versus prednisolone (PSL) in an endotoxin-induced uveitis (EIU) rat model. Intravenous administration of 100 mg/kg Tyr was performed 2 hr before, simultaneously and 2 hr after lipopolysaccharide (LPS) injection. Tyr treatment was associated with decreased inflammatory cell number, protein concentration, tumor necrosis factor (TNF)-α, PGE2 and NO levels in AqH and improvements in histopathologic evidence of EIU in ocular tissue at 24 hr after LPS injection. 100 mg/kg Tyr and 1 mg/kg PSL (administered on the same schedule as Tyr) had comparable anti-inflammatory effects. Taken together, Tyr may represent a promising therapeutic agent for the management of intraocular inflammatory diseases.
authors.affiliation: Department of Small Animal Internal Medicine I, School of Veterinary Medicine, University of Kitasato, 35-1, Towada, Aomori 034-8628, Japan.
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Sato
authors.forename: Yuko
authors.initials: Y
authors.lastname: Mihara
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Kanai
authors.forename: Yohei
authors.initials: Y
authors.lastname: Yamashita
authors.forename: Yuya
authors.initials: Y
authors.lastname: Kimura
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Itoh
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use*; D015232:Dinoprostone / Q000378:metabolism; D004731:Endotoxins; D007249:Inflammation / Q000188:drug therapy; D008297:Male; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011239:Prednisolone / Q000627:therapeutic use; D051381:Rats; D011917:Rats, Inbred Lew; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D014605:Uveitis / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D004731:Endotoxins; D014409:Tumor Necrosis Factor-alpha; C011867:4-hydroxyphenylethanol; D011239:Prednisolone; D015232:Dinoprostone; D010626:Phenylethyl Alcohol