title: Development of Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction.
abstract: Pulmonary hypertension (PH) is common in patients with heart failure with preserved ejection fraction (HFpEF). While PH-HFpEF may affect more than a million patients in the United States alone, it has been difficult to study its epidemiology and response to treatment due to difficulty in properly defining the illness. While chronic remodeling of the pulmonary vasculature is related to chronic passive congestion of the pulmonary circulation from the pulmonary veins, there are likely other contributors to the development of PH-HFpEF. We explore the potential direct contributions of obesity, diabetes mellitus, genetics, and sleep apnea on the pulmonary circulation in those with PH-HFpEF, and we discuss the potential role of exercise testing or fluid challenge during diagnostic testing.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Virginia Commonwealth University Health System, Richmond, VA, USA. Electronic address: Grant.Farr@vcuhealth.org.
authors.forename: Grant
authors.initials: G
authors.lastname: Farr
authors.affiliation: VCU Pauley Heart Center, Virginia Commonwealth University Health System, Richmond, VA, USA.
authors.forename: Keyur
authors.initials: K
authors.lastname: Shah
authors.affiliation: VCU Pauley Heart Center, Virginia Commonwealth University Health System, Richmond, VA, USA.
authors.forename: Roshi
authors.initials: R
authors.lastname: Markley
authors.affiliation: VCU Pauley Heart Center, Virginia Commonwealth University Health System, Richmond, VA, USA.
authors.forename: Antonio
authors.initials: A
authors.lastname: Abbate
authors.affiliation: Victoria Johnson Research Laboratories, Virginia Commonwealth University Health System, Richmond, VA, USA.
authors.forename: Fadi N
authors.initials: FN
authors.lastname: Salloum
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Virginia Commonwealth University Health System, Richmond, VA, USA.
authors.forename: Dan
authors.initials: D
authors.lastname: Grinnan
mesh_terms: D003952:Diagnostic Imaging; D018450:Disease Progression; D006333:Heart Failure / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D011652:Pulmonary Circulation / Q000502:physiology*; D013318:Stroke Volume / Q000502:physiology*
keywords: Diastolic dysfunction; Heart failure; Pulmonary hypertension