title: Aneuploidy in stem cells.
abstract: Stem cells hold enormous promise for regenerative medicine as well as for engineering of model systems to study diseases and develop new drugs. The discovery of protocols that allow for generating induced pluripotent stem cells (IPSCs) from somatic cells has brought this promise steps closer to reality. However, as somatic cells might have accumulated various chromosomal abnormalities, including aneuploidies throughout their lives, the resulting IPSCs might no longer carry the perfect blueprint for the tissue to be generated, or worse, become at risk of adopting a malignant fate. In this review, we discuss the contribution of aneuploidy to healthy tissues and how aneuploidy can lead to disease. Furthermore, we review the differences between how somatic cells and stem cells respond to aneuploidy.
authors.affiliation: Jorge Garcia-Martinez, Bjorn Bakker, Klaske M Schukken, Judith E Simon, Floris Foijer, European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, NL-9713 AV Groningen, The Netherlands.
authors.forename: Jorge
authors.initials: J
authors.lastname: Garcia-Martinez
authors.affiliation: Jorge Garcia-Martinez, Bjorn Bakker, Klaske M Schukken, Judith E Simon, Floris Foijer, European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, NL-9713 AV Groningen, The Netherlands.
authors.forename: Bjorn
authors.initials: B
authors.lastname: Bakker
authors.affiliation: Jorge Garcia-Martinez, Bjorn Bakker, Klaske M Schukken, Judith E Simon, Floris Foijer, European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, NL-9713 AV Groningen, The Netherlands.
authors.forename: Klaske M
authors.initials: KM
authors.lastname: Schukken
authors.affiliation: Jorge Garcia-Martinez, Bjorn Bakker, Klaske M Schukken, Judith E Simon, Floris Foijer, European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, NL-9713 AV Groningen, The Netherlands.
authors.forename: Judith E
authors.initials: JE
authors.lastname: Simon
authors.affiliation: Jorge Garcia-Martinez, Bjorn Bakker, Klaske M Schukken, Judith E Simon, Floris Foijer, European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, NL-9713 AV Groningen, The Netherlands.
authors.forename: Floris
authors.initials: F
authors.lastname: Foijer
keywords: Aneuploidy; Chromosomal instability; Embryonic stem cells; Induced pluripotent stem cells; Mesenchymal stem cells