title: Tumor Profiling: Adding Proteomics to Genomics.
abstract: Researchers have used mass spectrometry to conduct proteomic analyses of 77 genomically characterized breast tumors. Through this approach, they've uncovered functional consequences of somatic mutations. For instance, EGFR overexpression in basal-like breast cancer is potentially driven by the loss of two genes, SKP1 and CETN3, from the chromosome 5q deletion characteristic of this disease subtype.
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D023281:Genomics / Q000379:methods*; D006801:Humans; D013058:Mass Spectrometry; D010766:Phosphorylation; D020543:Proteome / Q000378:metabolism; D040901:Proteomics / Q000379:methods*
chemical_list: D020543:Proteome