title: The prognostic roles of ALDH1 isoenzymes in gastric cancer.
abstract: Increased aldehyde dehydrogenase 1 (ALDH1) activity has been determined to be present in the stem cells of several kinds of cancers including gastric cancer (GC). Nevertheless, which ones of ALDH1's isoenzymes are leading to ALDH1 activity remains elusive. In this study, we examined the prognostic value and hazard ratio (HR) of individual ALDH1 isoenzymes in patients with GC using "The Kaplan-Meier plotter" database. mRNA high expression level of ALDH1A1 was not found to be significantly correlated with the overall survival (OS) of all patients with GC followed for 20 years, HR =0.86 (95% confidence interval [CI]: 0.7-1.05), P=0.13. mRNA high expression level of ALDH1A2 was also not significantly correlated with OS for all patients with GC, HR =1.13 (95% CI: 0.91-1.41), P=0.25. mRNA high expression level of ALDH1A3 was found to be significantly correlated with worsened OS in either intestinal-type patients, HR =2.24 (95% CI: 1.44-3.49), P=0.00026, or diffuse-type patients, HR =1.91 (95% CI: 1.02-3.59), P=0.04. Interestingly, mRNA high expression level of ALDH1B1 was found to be significantly correlated with better OS for all patients with GC, HR =0.66 (95% CI: 0.53-0.81), P=7.8e-05, and mRNA high expression level of ALDH1L1 was found to be significantly correlated with worsened OS for all patients with GC, HR =1.23 (95% CI: 1-1.51), P=0.048. Furthermore, our results also indicate that ALDH1A3 and ALDH1L1 are potential major contributors to the ALDH1 activity in GC, since mRNA high expression levels of ALDH1A3 and ALDH1L1 were found to be significantly correlated with worsened OS for all patients with GC. Based on our study, ALDH1A3 and ALDH1L1 are potential prognostic markers and therapeutic targets for patients with GC.
authors.affiliation: Hepatobiliary Treatment Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China; Department of Medical Oncology, Baotou Cancer Hospital, Baotou, Inner Mongolia, People's Republic of China.
authors.forename: Kai
authors.initials: K
authors.lastname: Li
authors.affiliation: Surgical Department, Baotou Cancer Hospital, Baotou, Inner Mongolia, People's Republic of China.
authors.forename: Xiaoguang
authors.initials: X
authors.lastname: Guo
authors.affiliation: Department of Gastrointestinal Surgery, First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
authors.forename: Ziwei
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Medical Oncology, Baotou Cancer Hospital, Baotou, Inner Mongolia, People's Republic of China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Biology, Chongqing Medical University, Chongqing, People's Republic of China.
authors.forename: Youquan
authors.initials: Y
authors.lastname: Bu
authors.affiliation: Department of Pathology, Baotou Cancer Hospital, Baotou, Inner Mongolia, People's Republic of China.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Bai
authors.affiliation: Surgical Oncology, Baotou Cancer Hospital, Baotou, Inner Mongolia, People's Republic of China.
authors.forename: Liansheng
authors.initials: L
authors.lastname: Zheng
authors.affiliation: Department of Medical Oncology, Baotou Cancer Hospital, Baotou, Inner Mongolia, People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
keywords: ALDH1; KM plotter; cancer stem cell; hazard ratio; prognosis