title: Melanoma cell adhesion molecule as an emerging biomarker with prognostic significance in systolic heart failure.
abstract: BACKGROUND
  Melanoma cell adhesion molecule (MCAM) is a marker of endothelial damage. MCAM diagnostic and prognostic value was assessed in chronic heart failure (CHF).
  
  
  METHODS
  130 CHF patients and 32 controls were included in the study. Telephone follow-up lasted one year. End points were: death from all causes, and hospitalization with CHF exacerbation.
  
  
  RESULTS
  MCAM was higher in patients than in controls (p = 0.01). Receiver operator curve analysis revealed that MCAM may serve as a predictor of death (area under the curve: 0.8404; p < 0.002). Patients with MCAM above 500 ng/ml had worse prognosis (p = 0.03). NT-proBNP and age were independent predictors of death in multivariate analysis.
  
  
  CONCLUSIONS
  The increased MCAM indicates endothelial damage in CHF and may serve as a marker of worse prognosis in these patients.
authors.affiliation: IInd Clinic of Cardiology, Colegium Medicum of Nicolaus Copernicus University in Bydgoszcz, University Hospital nr 2 in Bydgoszcz, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Banach
authors.affiliation: IInd Clinic of Cardiology, Colegium Medicum of Nicolaus Copernicus University in Bydgoszcz, University Hospital nr 2 in Bydgoszcz, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Grochowska
authors.affiliation: Department of Immunology, Collegium Medicum of Nicolaus Copernicus University (NCU) in Bydgoszcz, Poland.
authors.forename: Lidia
authors.initials: L
authors.lastname: Gackowska
authors.affiliation: Department of Theoretical Foundations of Biomedical Sciences & Medical Informatics, Colegium Medicum of Nicolaus Copernicus University in Bydgoszcz, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Buszko
authors.affiliation: IInd Clinic of Cardiology, Colegium Medicum of Nicolaus Copernicus University in Bydgoszcz, University Hospital nr 2 in Bydgoszcz, Poland.
authors.forename: Robert
authors.initials: R
authors.lastname: Bujak
authors.affiliation: IInd Clinic of Cardiology, Colegium Medicum of Nicolaus Copernicus University in Bydgoszcz, University Hospital nr 2 in Bydgoszcz, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Gilewski
authors.affiliation: Department of Immunology, Collegium Medicum of Nicolaus Copernicus University (NCU) in Bydgoszcz, Poland.
authors.forename: Izabela
authors.initials: I
authors.lastname: Kubiszewska
authors.affiliation: IInd Clinic of Cardiology, Colegium Medicum of Nicolaus Copernicus University in Bydgoszcz, University Hospital nr 2 in Bydgoszcz, Poland.
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Wołowiec
authors.affiliation: Department of Immunology, Collegium Medicum of Nicolaus Copernicus University (NCU) in Bydgoszcz, Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Michałkiewicz
authors.affiliation: IInd Clinic of Cardiology, Colegium Medicum of Nicolaus Copernicus University in Bydgoszcz, University Hospital nr 2 in Bydgoszcz, Poland.
authors.forename: Władysław
authors.initials: W
authors.lastname: Sinkiewicz
mesh_terms: D000368:Aged; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis; D051929:CD146 Antigen / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D054143:Heart Failure, Systolic / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D011379:Prognosis; D016016:Proportional Hazards Models; D012372:ROC Curve; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D051929:CD146 Antigen; C497902:MCAM protein, human; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D002097:C-Reactive Protein
keywords: chronic heart failure; melanoma cell adhesion molecule; prognosis