title: Assessment of Coronary Flow Reserve by Adenosine Stress Myocardial Perfusion Imaging in Patients with Hypertension.
abstract: In this study, our aim was to assess the coronary flow reserve (CFR) by performing the adenosine stress (99m)Tc-MIBI single-photon computed tomographic (SPECT) myocardial perfusion imaging in patients with hypertension. 47 hypertensive patients with normal coronary angiography were divided into 2 groups, defined by the presence (LVH, n = 22) and absence (non-LVH, n = 25) of left ventricular hypertrophy with 17 normal cases as controls. All patients were administered the adenosine stress-rest (99m)Tc-MIBI scintigraphy. 0.14 mg/kg/min adenosine was administered by continuous infusion for 6 min. We found that adenosine-induced myocardial ischemia was present in 26 cases (55.3 %) with 87 segments (20.6 %) showing abnormal distribution in the hypertensive group versus a single case (5.9 %) (χ (2) = 31.12, P < 0.001) and segment (0.7 %) (χ (2) = 32.90, P < 0.001) in the control group by SPECT perfusion. In the LVH group, 17 cases (77.3 %) and 67 segments (33.8 %) of myocardial ischemia were present. In the non-LVH group, there were 9 cases (36.0 %) (χ (2) = 8.06, P < 0.001), 20 segments (8.9 %) (χ (2) = 40.13, P < 0.001). There was a significant decrease in coronary reserve in the hypertensive groups following adenosine infusion with a fourfold decrease in cases and a sixfold decrease in segments (P < 0.001). Our study suggests that assessing CFR by the (99m)Tc-MIBI adenosine stress by SPECT imaging is a relatively easy, safe, and non-invasive test in patients with hypertension. We noted a decrease in CFR in patients with hypertension. This decrease was especially remarkable for hypertensive patients with LVH. This study shows that administering the (99m)Tc-MIBI adenosine stress by SPECT imaging is a safe, simple, and non-invasive test for detecting CFR in patients with hypertension.
authors.affiliation: Department of Cardiology, Xuzhou Hospital Affiliated East South University School of Medicine, Xuzhou Cardiovascular Disease Institute, 199 Jiefang Road, Xuzhou, 221009, China. fuqiang@medmail.com.cn.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Fu
authors.affiliation: Department of Cardiology, Xuzhou Hospital Affiliated East South University School of Medicine, Xuzhou Cardiovascular Disease Institute, 199 Jiefang Road, Xuzhou, 221009, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Xuzhou Hospital Affiliated East South University School of Medicine, Xuzhou Cardiovascular Disease Institute, 199 Jiefang Road, Xuzhou, 221009, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Lu
authors.affiliation: Department of Cardiology, Xuzhou Hospital Affiliated East South University School of Medicine, Xuzhou Cardiovascular Disease Institute, 199 Jiefang Road, Xuzhou, 221009, China.
authors.forename: Yuetao
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Xuzhou Hospital Affiliated East South University School of Medicine, Xuzhou Cardiovascular Disease Institute, 199 Jiefang Road, Xuzhou, 221009, China.
authors.forename: Yijie
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Cardiology, Xuzhou Hospital Affiliated East South University School of Medicine, Xuzhou Cardiovascular Disease Institute, 199 Jiefang Road, Xuzhou, 221009, China.
authors.forename: Yanjiong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Xuzhou Hospital Affiliated East South University School of Medicine, Xuzhou Cardiovascular Disease Institute, 199 Jiefang Road, Xuzhou, 221009, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wu
authors.affiliation: Department of Cardiology, Xuzhou Hospital Affiliated East South University School of Medicine, Xuzhou Cardiovascular Disease Institute, 199 Jiefang Road, Xuzhou, 221009, China.
authors.forename: Cunzhi
authors.initials: C
authors.lastname: Lu
mesh_terms: D000241:Adenosine / Q000008:administration & dosage* / Q000494:pharmacology; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000502:physiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000000981:diagnostic imaging*; D017379:Hypertrophy, Left Ventricular / Q000150:complications; D008297:Male; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging; D017256:Technetium Tc 99m Sestamibi / Q000737:chemistry; D015899:Tomography, Emission-Computed, Single-Photon; D016277:Ventricular Function, Left / Q000187:drug effects
chemical_list: D017256:Technetium Tc 99m Sestamibi; D000241:Adenosine
keywords: Adenosine; Coronary flow reserve; Hypertension; Myocardial perfusion imaging