title: Megakaryocytes regulate the quiescence of hematopoietic stem cells through PF4: 2013 ASH meeting highlights.
abstract: Hematopoietic stem cells (HSCs) can take one of the three different pathways: quiescence, self-renewal and differentiation. Mechanisms that control the tight balance to maintain lifelong hematopoietic homeostasis have been a major interest of research. Platelet factor-4 (PF4), a weak chemokine, is synthesized exclusively by megakaryocytes and sequestered in platelets. This meeting report highlights a novel study presented at 2013 ASH annual meeting. This study found that megakaryocyte, a progeny of HSC, was involved in maintaining quiescence of HSCs via PF4 in a feedback loop.
authors.affiliation: 1 Department of Hematology, Xiamen Zhongshan Hospital, Xiamen 361001, China ; 2 Henan Tumor Hospital, Zhengzhou University, Zhengzhou 450003, China.
authors.forename: Yamei
authors.initials: Y
authors.lastname: Chen
authors.affiliation: 1 Department of Hematology, Xiamen Zhongshan Hospital, Xiamen 361001, China ; 2 Henan Tumor Hospital, Zhengzhou University, Zhengzhou 450003, China.
authors.forename: Delong
authors.initials: D
authors.lastname: Liu
keywords: Hematopoietic stem cell (HSC); megakaryocytes; platelet factor-4 (PF4)