title: Targeting cancer stem cells with oncolytic virus.
abstract: Cancer stem cells (CSCs) represent a distinct subpopulation of cancer cells which are shown to be relatively resistant to conventional anticancer therapies and have been correlated to disease recurrence. Oncolytic viruses utilize methods of cell killing that differ from traditional therapies and thus are able to elude the typical mechanisms that CSCs use to resist current chemotherapies and radiotherapies. Moreover, genetically engineered oncolytic viruses may further augment the oncolytic effects. Here we review the recent data regarding the ability of several oncolytic viruses to eradicate CSCs.
authors.affiliation: 1 Department of Hematology, Shanghai General Hospital, Shanghai 200080, China ; 2 Institute of Hematology, the First Afflilated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Tong
authors.affiliation: 1 Department of Hematology, Shanghai General Hospital, Shanghai 200080, China ; 2 Institute of Hematology, the First Afflilated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.
authors.forename: Wenbin
authors.initials: W
authors.lastname: Qian
keywords: Cancer stem cell (CSC); oncolytic; virotherapy