title: Basosquamous Carcinoma: Controversy, Advances, and Future Directions.
abstract: BACKGROUND
  Basosquamous carcinoma is a rare cutaneous neoplasm that has caused considerable controversy as to its classification, pathogenesis, and management.
  
  
  OBJECTIVE
  To review and summarize current literature on the definition, pathogenesis, incidence, and management of basosquamous carcinoma.
  
  
  METHODS
  Through December 2015, an electronic search of the Pubmed database was performed using combinations of basosquamous carcinoma and metatypical basal cell carcinoma as search terms.
  
  
  RESULTS
  A selection of 39 publications including case reports and series, retrospective studies, and systematic reviews of the literature were included. Descriptions of the definition of basosquamous carcinoma, clinical behavior, histopathological characteristics, current treatment therapies, and future advances are summarized.
  
  
  CONCLUSIONS
  This systematic review provides a comprehensive overview of the current understanding of basosquamous carcinoma. Further study is required to elucidate the mechanisms driving the formation of this aggressive tumor.
authors.affiliation: Departments of *Dermatology, and †Pathology, School of Medicine, Stanford University, Redwood City, California.
authors.forename: Caroline Z
authors.initials: CZ
authors.lastname: Tan
authors.forename: Kerri E
authors.initials: KE
authors.lastname: Rieger
authors.forename: Kavita Y
authors.initials: KY
authors.lastname: Sarin
mesh_terms: D000813:Anilides / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002281:Carcinoma, Basosquamous / Q000737:chemistry / Q000473:pathology* / Q000628:therapy*; D003131:Combined Modality Therapy; D006801:Humans; D007150:Immunohistochemistry; D015580:Mohs Surgery; D011725:Pyridines / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy*
chemical_list: D000813:Anilides; D000970:Antineoplastic Agents; C538724:HhAntag691; D011725:Pyridines