title: Diet-related DNA adduct formation in relation to carcinogenesis.
abstract: The human diet contributes significantly to the initiation and promotion of carcinogenesis. It has become clear that the human diet contains several groups of natural foodborne chemicals that are at least in part responsible for the genotoxic, mutagenic, and carcinogenic potential of certain foodstuffs. Electrophilic chemicals are prone to attack nucleophilic sites in DNA, resulting in the formation of altered nucleobases, also known as DNA adducts. Since DNA adduct formation is believed to signal the onset of chemically induced carcinogenesis, the DNA adduct-inducing potential of certain foodstuffs has been investigated to gain more insight into diet-related pathways of carcinogenesis. Many studies have investigated diet-related DNA adduct formation. This review summarizes work on known or suspected dietary carcinogens and the role of DNA adduct formation in hypothesized carcinogenesis pathways.
authors.affiliation: L.Y. Hemeryck and L. Vanhaecke are with the Laboratory of Chemical Analysis, Department of Veterinary Public Health and Food Safety, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium. lynn.vanhaecke@ugent.be.
authors.forename: Lieselot Y
authors.initials: LY
authors.lastname: Hemeryck
authors.affiliation: L.Y. Hemeryck and L. Vanhaecke are with the Laboratory of Chemical Analysis, Department of Veterinary Public Health and Food Safety, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
authors.forename: Lynn
authors.initials: L
authors.lastname: Vanhaecke
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000139:chemically induced*; D002273:Carcinogens; D004247:DNA / Q000737:chemistry; D018736:DNA Adducts; D004249:DNA Damage; D004032:Diet; D005502:Food; D006801:Humans; D009369:Neoplasms / Q000139:chemically induced
chemical_list: D002273:Carcinogens; D018736:DNA Adducts; D004247:DNA
keywords: DNA damage; cancer risk; carcinogenesis; food chemicals; food contaminants; toxins