title: Impact of Frailty and Other Geriatric Syndromes on Clinical Management and Outcomes in Elderly Patients With Non-ST-Segment Elevation Acute Coronary Syndromes: Rationale and Design of the LONGEVO-SCA Registry.
abstract: The incidence of acute coronary syndromes (ACS) is high in the elderly. Despite a high prevalence of frailty and other aging-related variables, little information exists about the optimal clinical management in patients with coexisting geriatric syndromes. The aim of the LONGEVO-SCA registry (Impacto de la Fragilidad y Otros Síndromes Geriátricos en el Manejo y Pronóstico Vital del Anciano con Síndrome Coronario Agudo sin Elevación de Segmento ST) is to assess the impact of aging-related variables on clinical management, prognosis, and functional status in elderly patients with ACS. A series of 500 consecutive octogenarian patients with non-ST-segment elevation ACS from 57 centers in Spain will be included. A comprehensive geriatric assessment will be performed during the admission, assessing functional status (Barthel Index, Lawton-Brody Index), frailty (FRAIL scale, Short Physical Performance Battery), comorbidity (Charlson Index), nutritional status (Mini Nutritional Assessment-Short Form), and quality of life (Seattle Angina Questionnaire). Patients will be managed according to current recommendations. The primary outcome will be the description of mortality and its causes at 6 months. Secondary outcomes will be changes in functional status and quality of life. Results from this study might significantly improve the knowledge about the impact of aging-related variables on management and outcomes of elderly patients with ACS. Clinical management of these patients has become a major health care problem due to the growing incidence of ACS in the elderly and its particularities.
authors.affiliation: Bellvitge University Hospital, University of Barcelona, Barcelona, Spain.
authors.forename: Oriol
authors.initials: O
authors.lastname: Alegre
authors.affiliation: Bellvitge University Hospital, University of Barcelona, Barcelona, Spain.
authors.forename: Albert
authors.initials: A
authors.lastname: Ariza-Solé
authors.affiliation: Hospital General Universitario Gregorio Marañón, Universidad Europea y Universidad Complutense de Madrid, Madrid, Spain.
authors.forename: María T
authors.initials: MT
authors.lastname: Vidán
authors.affiliation: Bellvitge University Hospital, University of Barcelona, Barcelona, Spain.
authors.forename: Francesc
authors.initials: F
authors.lastname: Formiga
authors.affiliation: Hospital General Universitario Gregorio Marañón, Universidad Europea y Universidad Complutense de Madrid, Madrid, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Martínez-Sellés
authors.affiliation: Centro Nacional de Investigaciones Cardiovasculares (CNIC), Instituto de Investigación y Departamento de Cardiología, Hospital Universitario 12 de Octubre, Universidad Complutense de Madrid, Madrid, Spain.
authors.forename: Héctor
authors.initials: H
authors.lastname: Bueno
authors.affiliation: Hospital Clínico Universitario de Valencia, Universidad de Valencia, Valencia, Spain.
authors.forename: Juan
authors.initials: J
authors.lastname: Sanchís
authors.affiliation: Hospital Universitario San Juan, Alicante, Spain.
authors.forename: Ramón
authors.initials: R
authors.lastname: López-Palop
authors.affiliation: Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain.
authors.forename: Emad
authors.initials: E
authors.lastname: Abu-Assi
authors.affiliation: Bellvitge University Hospital, University of Barcelona, Barcelona, Spain.
authors.forename: Àngel
authors.initials: À
authors.lastname: Cequier
mesh_terms: D054058:Acute Coronary Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D000369:Aged, 80 and over; D017023:Coronary Angiography; D019468:Disease Management; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D015577:Geriatric Assessment; D006801:Humans; D015994:Incidence; D008297:Male; D011446:Prospective Studies; D012042:Registries; D013030:Spain / Q000453:epidemiology; D015996:Survival Rate / Q000639:trends