title: New Prospects toward the Synthesis of Difluoromethylated Phosphate Mimics.
abstract: The difluoromethyl phosphonate motif plays a crucial role in the development of bioactive molecules as it is considered as a phosphate bioisoster. Since 2010, a renewal of interest to enlarge the panel of reactions to access these difluoromethylated phosphonate-containing molecules has been witnessed. This Concept article charts the recent progress that has been made.
authors.affiliation: Normandie Univ., INSA Rouen, UNIROUEN, CNRS, COBRA, 76000, Rouen, France.
authors.forename: Maria V
authors.initials: MV
authors.lastname: Ivanova
authors.affiliation: Normandie Univ., INSA Rouen, UNIROUEN, CNRS, COBRA, 76000, Rouen, France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Bayle
authors.affiliation: Normandie Univ., INSA Rouen, UNIROUEN, CNRS, COBRA, 76000, Rouen, France.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Besset
authors.affiliation: Normandie Univ., INSA Rouen, UNIROUEN, CNRS, COBRA, 76000, Rouen, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Pannecoucke
authors.affiliation: Normandie Univ., INSA Rouen, UNIROUEN, CNRS, COBRA, 76000, Rouen, France. thomas.poisson@insa-rouen.fr.
authors.forename: Thomas
authors.identifier: http://orcid.org/0000-0002-0503-9620
authors.initials: T
authors.lastname: Poisson
keywords: bioisosters; fluorinated phosphonates; fluorine; phosphate mimics; synthetic methods