title: Attenuation effect of Abnormal Savda Munziq on liver and heart toxicity caused by chemotherapy in mice.
abstract: Abnormal Savda Munziq (ASMq), an Uighur medicine formula commonly used in the treatment of cancer, has been speculated to possess antioxidative and antiproliferative effects, and to regulate immune activity. The present study was designed to systematically elucidate the toxicity-reducing activity of ASMq in mice undergoing combination chemotherapy with doxorubicin and 5-fluorouracil (5-FU). The mice were divided into normal (saline, 10 ml/kg) and doxorubicin + 5-FU groups (doxorubicin, 2.5 mg/kg; 5-FU, 10 mg/kg on alternate days). In addition, three groups received different doses of ASMq (2, 4 and 8 g/kg), in addition to doxorubicin (2.5 mg/kg) and 5-FU (10 mg/kg) treatment on alternate days. The histology of the heart and liver, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activity, malondialdehyde (MDA) concentrations in heart homogenate, and various biochemical parameters of the liver were evaluated. Compared with the normal control group, ASMq dose-dependently improved a number of variables, including body weight, liver index, transaminase and total protein, and partially normalized liver and cardiac pathology. ASMq restored activities of defense antioxidant enzymes SOD and GSH-Px towards normal levels, and decreased MDA concentration in dose-dependent manner. These results demonstrated that ASMq provides significant protection against doxorubicin + 5-FU combination induced hepatotoxicity and cardiotoxicity. Further studies are required to determine the effects of ASMq against doxorubicin + 5-FU-induced toxicity during chemotherapyin vivo.
authors.affiliation: Department of Drug Analysis, Faculty of Pharmacy, Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China.
authors.forename: Ainiwaer
authors.initials: A
authors.lastname: Aikemu
authors.affiliation: Faculty of Traditional Uighur Medicine, Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China.
authors.forename: Nurmuhamat
authors.initials: N
authors.lastname: Amat
authors.affiliation: Faculty of Traditional Uighur Medicine, Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China.
authors.forename: Abdiryim
authors.initials: A
authors.lastname: Yusup
authors.affiliation: Department of Drug Analysis, Faculty of Pharmacy, Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China.
authors.forename: Lianlian
authors.initials: L
authors.lastname: Shan
authors.affiliation: Medical Research Center, The First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China.
authors.forename: Xinwei
authors.initials: X
authors.lastname: Qi
authors.affiliation: Faculty of Traditional Uighur Medicine, Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China.
authors.forename: Halmurat
authors.initials: H
authors.lastname: Upur
keywords: abnormal Savda Munziq; anthraquinone; antioxidant effect; chemotherapy; toxicity