title: Genes Involved in Interleukin-1 Receptor Type II Activities Are Associated With Asthmatic Phenotypes.
abstract: OBJECTIVE
  Interleukin-1 (IL-1) plays a key role in inflammation and immunity and its decoy receptor, IL-1R2, has been implicated in transcriptomic and genetic studies of asthma.
  
  
  METHODS
  Two large asthma family collections, the French-Canadian Saguenay-Lac-St-Jean (SLSJ) study and the French Epidemiological Study on the Genetics and Environment of Asthma (EGEA), were used to investigate the association of SNPs in 10 genes that modulate IL-1R2 activities with asthma, allergic asthma, and atopy. Gene-gene interactions were also tested.
  
  
  RESULTS
  One SNP in BACE2 was associated with allergic asthma in the SLSJ study and replicated in the EGEA study before statistical correction for multiple testing. Additionally, two SNPs in the MMP2 gene were replicated in both studies prior to statistical correction and reached significance in the combined analysis. Moreover, three gene-gene interactions also survived statistical correction in the combined analyses (BACE1-IL1RAP in asthma and allergic asthma and IL1R1-IL1RAP in atopy).
  
  
  CONCLUSIONS
  Our results highlight the relevance of genes involved in the IL-1R2 activity in the context of asthma and asthma-related traits.
authors.affiliation: Département des sciences fondamentales, Université du Québec à Chicoutimi, Chicoutimi, Canada.
authors.forename: Anne Marie
authors.initials: AM
authors.lastname: Madore
authors.affiliation: Département des sciences fondamentales, Université du Québec à Chicoutimi, Chicoutimi, Canada.
authors.forename: Vanessa T
authors.initials: VT
authors.lastname: Vaillancourt
authors.affiliation: INSERM, U946, Genetic Variation and Human Diseases Unit, Paris, France.|Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Bouzigon
authors.affiliation: INSERM, U946, Genetic Variation and Human Diseases Unit, Paris, France.|Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France.
authors.forename: Chloé
authors.initials: C
authors.lastname: Sarnowski
authors.affiliation: INSERM, U946, Genetic Variation and Human Diseases Unit, Paris, France.|Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France.
authors.forename: Florent
authors.initials: F
authors.lastname: Monier
authors.affiliation: INSERM, U946, Genetic Variation and Human Diseases Unit, Paris, France.|Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France.
authors.forename: Marie Hélène
authors.initials: MH
authors.lastname: Dizier
authors.affiliation: INSERM, U946, Genetic Variation and Human Diseases Unit, Paris, France.|Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Demenais
authors.affiliation: Département des sciences fondamentales, Université du Québec à Chicoutimi, Chicoutimi, Canada. Catherine.laprise@uqac.ca.
authors.forename: Catherine
authors.initials: C
authors.lastname: Laprise
keywords: Atopy; IL1R1; IL1R2; SNP×SNP; asthma; genetic