title: [Desoxypipradrol - a new (already well known) designer drug].
abstract: Novel psychoactive substances (NPS) are easily accessible and the consumption has increased in recent years. New compounds as well as compounds derived from pharmaceutical research or the patent literature are provided, mostly without any declaration. As a consequence, severe adverse reactions may occur after consumption of unknown doses of these drugs, in particular after mixed intake of different psychoactive substances or co-medication. The toxic effects in such cases are not predictable. We report cases of rhabdomyolysis in patients after consumption of desoxipipradrol in combination with other NPS. Particularly in case of synergistic serotonergic effects a distinct stimulation of 5-HT2A-receptors (or 5-HT1A-receptors) should be considered which may lead to serotonergic syndrome.
authors.forename: Dieter
authors.initials: D
authors.lastname: Müller
authors.forename: Verena
authors.initials: V
authors.lastname: Angerer
authors.forename: Josephine
authors.initials: J
authors.lastname: Kithinji
authors.forename: Volker
authors.initials: V
authors.lastname: Auwärter
authors.forename: Hartmud
authors.initials: H
authors.lastname: Neurath
authors.forename: Gesine
authors.initials: G
authors.lastname: Liebetrau
authors.forename: Simone
authors.initials: S
authors.lastname: Just
authors.forename: Maren
authors.initials: M
authors.lastname: Hermanns-Clausen
mesh_terms: D000293:Adolescent; D000328:Adult; D015198:Designer Drugs / Q000506:poisoning*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D013287:Illicit Drugs / Q000506:poisoning*; D008297:Male; D010880:Piperidines / Q000506:poisoning*; D011619:Psychotropic Drugs / Q000506:poisoning*; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D020230:Serotonin Syndrome / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D055815:Young Adult
chemical_list: D015198:Designer Drugs; D013287:Illicit Drugs; D010880:Piperidines; D011619:Psychotropic Drugs; C084901:2-diphenylmethylpiperidine