title: Retinal metastasis from unknown primary: diagnosis, management, and clinicopathologic correlation.
abstract: A 75-year-old man was incidentally found to have a yellow-white retinal lesion with scattered hemorrhages. He was empirically treated elsewhere for viral retinitis without resolution and later transferred to the Vanderbilt Eye Institute, where retinal biopsy with silicone oil tamponade showed retinal metastasis. He had no prior history of cancer, and multiple systemic imaging evaluations failed to identify a primary site. Histopathology and immunohistochemistry of the biopsy were consistent with non-small-cell lung carcinoma. Due to the radiation-attenuating properties of silicone oil, the patient underwent silicone oil removal prior to receiving external beam radiotherapy (EBRT). The retinal metastasis responded completely to EBRT, and at final follow-up, 18 months after initial presentation, no primary tumor has been identified.
authors.affiliation: Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, Tennessee;
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Taubenslag
authors.affiliation: Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, Tennessee;
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Kim
authors.affiliation: Department of Radiation Oncology, Vanderbilt University Medical Center;; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center;
authors.forename: Albert
authors.initials: A
authors.lastname: Attia
authors.affiliation: Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center;; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center;
authors.forename: Ty W
authors.initials: TW
authors.lastname: Abel
authors.affiliation: Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center;; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center;
authors.forename: Hilary Highfield
authors.initials: HH
authors.lastname: Nickols
authors.affiliation: Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center;; Medical Oncology, Department of Medicine, Vanderbilt University Medical Center;
authors.forename: Kristin K
authors.initials: KK
authors.lastname: Ancell
authors.affiliation: Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, Tennessee;; Department of Radiation Oncology, Vanderbilt University Medical Center;; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center;; Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee.
authors.forename: Anthony B
authors.initials: AB
authors.lastname: Daniels
mesh_terms: D000368:Aged; D001706:Biopsy; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D009382:Neoplasms, Unknown Primary / Q000175:diagnosis* / Q000628:therapy; D012160:Retina / Q000000981:diagnostic imaging*; D019572:Retinal Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy; D041623:Tomography, Optical Coherence