title: Insulin-Like Peptide 5 Interacts with Sex Hormones and Metabolic Parameters in a Gender and Adiposity Dependent Manner in Humans.
abstract: Insulin-like peptide 5 (INSL5) is a gut hormone produced by L-cells in the colorectal epithelium and may play a role in the regulation of metabolic processes. The biological role of INSL5 is poorly investigated and nothing is known about the role of this hormone in obese and lean humans. Two cohorts were analyzed in the study. In the first cohort (n=76) the relationship between serum levels of INSL5 and different metabolic and hormonal parameters in obese and lean men and women were investigated. In the second cohort 14 male subjects underwent bariatric surgery. Circulating levels of INSL5 were then measured before and after interventions.We report for the first time that circulating INSL5 interacts with multiple metabolic and hormonal variables in lean and obese men and women and is affected by bariatric surgery. Serum levels of INSL5 negatively correlated with testosterone and blood lipids but positively with cortisol in obese men. In contrast to males, obese women had a strong negative correlation of plasma levels of INSL5 with C-reactive protein (CRP). We observed that adipose tissue loss after bariatric surgery significantly reduced serum levels of INSL5 in obese men with and without Type 2 Diabetes Mellitus (T2DM) that was associated with the restoration of circulating levels of testosterone. All together, our data demonstrated that INSL5 may interact with some metabolic parameters in obese humans and this process is dependent of gender and obesity state.
authors.affiliation: Department of Women and Child Health, Pediatric Endocrinology Unit, Karolinska Institutet, Stockholm, Sweden.
authors.forename: I V
authors.initials: IV
authors.lastname: Wagner
authors.affiliation: Division of Endocrinology, Department of Medicine, University of Leipzig, Leipzig, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Flehmig
authors.affiliation: Center for Pediatric Research Leipzig, Department of Women's and Child Health, University Hospital for Children & Adolescents, University of Leipzig, Leipzig, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Scheuermann
authors.affiliation: Center for Pediatric Research Leipzig, Department of Women's and Child Health, University Hospital for Children & Adolescents, University of Leipzig, Leipzig, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Löffler
authors.affiliation: Center for Pediatric Research Leipzig, Department of Women's and Child Health, University Hospital for Children & Adolescents, University of Leipzig, Leipzig, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Körner
authors.affiliation: Center for Pediatric Research Leipzig, Department of Women's and Child Health, University Hospital for Children & Adolescents, University of Leipzig, Leipzig, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Kiess
authors.affiliation: Integrated Research and Treatment Center (IFB Adiposity Diseases), University of Leipzig, Leipzig, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Stumvoll
authors.affiliation: Integrated Research and Treatment Center (IFB Adiposity Diseases), University of Leipzig, Leipzig, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Dietrich
authors.affiliation: Integrated Research and Treatment Center (IFB Adiposity Diseases), University of Leipzig, Leipzig, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Blüher
authors.affiliation: Integrated Research and Treatment Center (IFB Adiposity Diseases), University of Leipzig, Leipzig, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Klöting
authors.affiliation: Department of Women and Child Health, Pediatric Endocrinology Unit, Karolinska Institutet, Stockholm, Sweden.
authors.forename: O
authors.initials: O
authors.lastname: Söder
authors.affiliation: Department of Women and Child Health, Pediatric Endocrinology Unit, Karolinska Institutet, Stockholm, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Svechnikov
mesh_terms: D050154:Adiposity; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000378:metabolism*; D016022:Case-Control Studies; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D012739:Gonadal Steroid Hormones / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D008297:Male; D024821:Metabolic Syndrome / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000503:physiopathology; D011379:Prognosis; D011506:Proteins / Q000378:metabolism*; D013851:Thinness / Q000150:complications* / Q000503:physiopathology; D055815:Young Adult
chemical_list: D015415:Biomarkers; D012739:Gonadal Steroid Hormones; D007328:Insulin; C084797:Leydig insulin-like protein; D011506:Proteins