title: Can monocytosis act as an independent variable for predicting deep vein thrombosis?
abstract: BACKGROUND
  Deep venous thrombosis (DVT) is a manifestation of venous thromboembolism (VTE). It has been estimated that there are 900,000 cases of pulmonary emboli (PE) and DVT per year resulting in 60,000 to 300,000 deaths. About two-thirds of VTE cases are associated with prolonged hospitalizations, emphasizing the importance of major surgery or immobilization as risk factors.
  
  
  METHODS
  Retrospective study conducted in a Metropolitan Hospital. A total of 46 records were obtained from the hospital database following the established inclusion and exclusion criteria. For the control group a total of 42 records were selected. Patients included in this study were admitted with the diagnosis of deep venous thrombosis identified either by lower leg Doppler.
  
  
  RESULTS
  Monocytosis with DVT, p-value was <0.001, with an Odd Ratio (OR) 9.35 and Interval Confidence (IC) 95% (3.2-27.3). The p-value for eosinophilia with DVT was 0.092, for males with DVT the p-value was 0.35 and age related groups with DVT value was 0.720. Sensitivity of monocytosis was 67.3%, specificity 80%, positive predictive value (PPV) 79.49% and negative predictive value (NPV) 63.9%.
  
  
  CONCLUSIONS
  This study revealed the association between monocytosis and DVT, thus patients with monocytosis are more likely to develop DVT. This evidence is consistent with previous studies establishing that monocytes could have an important role with the coagulation cascade activation and the formation of DVT. The association of monocyte count and DVT can be used in the future as a significant tool in those patients with suspected DVT to increase diagnostic yield.
authors.affiliation: Internal Medicine Residency Program, San Juan City Hospital, San Juan, Puerto Rico. Electronic address: jeffreymaldo@gmail.com.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Maldonado-Peña
authors.affiliation: Internal Medicine Residency Program, San Juan City Hospital, San Juan, Puerto Rico.
authors.forename: Kelvin
authors.initials: K
authors.lastname: Rivera
authors.affiliation: Internal Medicine Residency Program, San Juan City Hospital, San Juan, Puerto Rico.
authors.forename: Cesar
authors.initials: C
authors.lastname: Ortega
authors.affiliation: Internal Medicine Residency Program, San Juan City Hospital, San Juan, Puerto Rico.
authors.forename: M
authors.initials: M
authors.lastname: Betancourt
authors.affiliation: Cardiology Department, San Juan City Hospital, San Juan, Puerto Rico.
authors.forename: Jorge Edwin
authors.initials: JE
authors.lastname: Lugo
authors.affiliation: Division of Cardiology, Department of Medicine, University of Puerto Rico School of Medicine, Puerto Rico.
authors.forename: Edinson
authors.initials: E
authors.lastname: Camargo
mesh_terms: D000328:Adult; D000368:Aged; D006801:Humans; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism* / Q000473:pathology; D011237:Predictive Value of Tests; D011647:Puerto Rico / Q000453:epidemiology; D012189:Retrospective Studies; D020246:Venous Thrombosis / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology
keywords: Deep vein thrombosis; Monocytosis