title: Treatment of fistula-in-ano with cyanoacrylate glue with and without prior seton placement in rats.
abstract: OBJECTIVE
  To evaluate the efficacy of ethyl-cyanoacrylate in the treatment of fístula-in-ano in rats with and without prior seton placement.
  
  
  METHODS
  Thirty rats Wistar with fístula-in-ano produced surgically, distributed in three groups: group A (ethyl-cyanoacrylate) - treated by application of ethyl-cyanoacrylate into fístula tract; group B (seton + ethyl-cyanoacrylate) - seton placement followed by application of ethyl-cyanoacrylate into fístula tract, 30 days later; group C (control) - no treatment. After 60 days the animals were submited to euthanasia and the specimens were analyzed by pathologist. The results were analyzed by Chi-square test with significant value of p<0.05.
  
  
  RESULTS
  One animal of group B died. Were found tracts fully healed: 7, 5 and 2, in groups A, B and C, respectivelly. There was a statistically significant difference between groups A and C (p=0.02). When joined all animals treated with glue (A + B) compared to group C there was also statistically significant difference (p=0.02).
  
  
  CONCLUSIONS
  The use of ethyl-cyanoacrylate glue was effective in closing anal fistulae in rats. There was no advantage in the prior application of seton.
authors.affiliation: MD, Resident, Department of Surgery, Universidade Federal do Mato Grosso do Sul(UFMS), Brazil. Acquisition, interpretation and analysis of data.
authors.forename: Gustavo Tominaga
authors.initials: GT
authors.lastname: Romero
authors.affiliation: PhD, Associate Professor, Department of Surgery, UFMS, Campo Grande-MS, Brazil. Conception and design of the study, interpretation of data, manuscript writing, critical revision.
authors.forename: Carlos Henrique Marques Dos
authors.initials: CH
authors.lastname: Santos
authors.affiliation: Master, Fellow PhD degree, Postgraduate Program in Saúde e Desenvolvimento da Região Centro-Oeste, UFMS, Campo Grande-MS, Brazil. Technical procedures, acquisition of data.
authors.forename: Pedro Carvalho
authors.initials: PC
authors.lastname: Cassino
authors.affiliation: PhD, Associate Professor, Department of Pathology, UFMS, Campo Grande-MS, Brazil. Histopathological examinations.
authors.forename: Maçanori
authors.initials: M
authors.lastname: Odashiro
authors.affiliation: Graduate student, School of Medicine, UFMS, Campo Grande-MS, Brazil. Acquisition, interpretation and analysis of data.
authors.forename: Gisele Zocoller
authors.initials: GZ
authors.lastname: Seno
authors.affiliation: Graduate student, School of Pharmacy, UFMS, Campo Grande-MS, Brazil. Acquisition, interpretation and analysis of data.
authors.forename: Gabriela Flávia
authors.initials: GF
authors.lastname: Aléssio
mesh_terms: D000818:Animals; D003131:Combined Modality Therapy / Q000379:methods; D003487:Cyanoacrylates / Q000627:therapeutic use*; D004322:Drainage / Q000379:methods*; D008297:Male; D023421:Models, Animal; D011184:Postoperative Period; D017208:Rats, Wistar; D012003:Rectal Fistula / Q000188:drug therapy* / Q000601:surgery; D014014:Tissue Adhesives / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D003487:Cyanoacrylates; D014014:Tissue Adhesives; C029054:ethyl 2-cyanoacrylate