title: Cerebellar liponeurocytoma in two siblings suggests a possible familial predisposition.
abstract: There is limited data on the genetic origin and natural history of cerebellar liponeurocytoma. To the best of our knowledge there has been only one report of a familial presentation of this rare entity. We report a 72-year-old female with a posterior fossa tumor presenting with progressive cerebellar signs and symptoms. The patient underwent total tumor resection via an uncomplicated sub-occipital craniotomy. Histopathologic examination was diagnostic for cerebellar liponeurocytoma. Her sister was previously treated for a similar tumor. Our report provides further evidence for the possible existence of a hereditary abnormality predisposing afflicted families to cerebellar liponeurocytoma development.
authors.affiliation: Department of Neurosurgery, "Korgialenio Benakio" Red Cross Hospital of Athens, Athens 11526, Greece.
authors.forename: Stylianos
authors.initials: S
authors.lastname: Pikis
authors.affiliation: Department of Pathology, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel.
authors.forename: Yakov
authors.initials: Y
authors.lastname: Fellig
authors.affiliation: Department of Neurosurgery, Hadassah-Hebrew University Medical Center, Kiryat Hadassah, P.O. Box 12000, Jerusalem 91120, Israel. Electronic address: EmilM@hadassah.org.il.
authors.forename: Emil
authors.initials: E
authors.lastname: Margolin
mesh_terms: D000368:Aged; D002528:Cerebellar Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008067:Lipoma / Q000473:pathology; D008279:Magnetic Resonance Imaging; D018306:Neurocytoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D035781:Siblings; D016896:Treatment Outcome
keywords: Biology; Cerebellar liponeurocytomas; Familial; Inheritance