title: Vagus nerve stimulation: state of the art of stimulation and recording strategies to address autonomic function neuromodulation.
abstract: Neural signals along the vagus nerve (VN) drive many somatic and autonomic functions. The clinical interest of VN stimulation (VNS) is thus potentially huge and has already been demonstrated in epilepsy. However, side effects are often elicited, in addition to the targeted neuromodulation.
  
  
  
  This review examines the state of the art of VNS applied to two emerging modulations of autonomic function: heart failure and obesity, especially morbid obesity.
  
  
  
  We report that VNS may benefit from improved stimulation delivery using very advanced technologies. However, most of the results from fundamental animal studies still need to be demonstrated in humans.
authors.affiliation: Inria, DEMAR, Montpellier, France. University of Montpellier, DEMAR, Montpellier, France.
authors.forename: David
authors.initials: D
authors.lastname: Guiraud
authors.forename: David
authors.initials: D
authors.lastname: Andreu
authors.forename: Stéphane
authors.initials: S
authors.lastname: Bonnet
authors.forename: Guy
authors.initials: G
authors.lastname: Carrault
authors.forename: Pascal
authors.initials: P
authors.lastname: Couderc
authors.forename: Albert
authors.initials: A
authors.lastname: Hagège
authors.forename: Christine
authors.initials: C
authors.lastname: Henry
authors.forename: Alfredo
authors.initials: A
authors.lastname: Hernandez
authors.forename: Nicole
authors.initials: N
authors.lastname: Karam
authors.forename: Virginie
authors.initials: V
authors.lastname: Le Rolle
authors.forename: Philippe
authors.initials: P
authors.lastname: Mabo
authors.forename: Paweł
authors.initials: P
authors.lastname: Maciejasz
authors.forename: Charles-Henri
authors.initials: CH
authors.lastname: Malbert
authors.forename: Eloi
authors.initials: E
authors.lastname: Marijon
authors.forename: Sandrine
authors.initials: S
authors.lastname: Maubert
authors.forename: Chloé
authors.initials: C
authors.lastname: Picq
authors.forename: Olivier
authors.initials: O
authors.lastname: Rossel
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Bonnet
mesh_terms: D000818:Animals; D001341:Autonomic Nervous System / Q000033:anatomy & histology / Q000502:physiology*; D004827:Epilepsy / Q000503:physiopathology; D006801:Humans; D009424:Nervous System Physiological Phenomena; D014630:Vagus Nerve / Q000502:physiology; D055536:Vagus Nerve Stimulation / Q000639:trends*