title: Associations between parameters of flow-mediated vasodilatation obtained by continuous measurement approaches and the presence of coronary artery disease and the severity of coronary atherosclerosis.
abstract: We investigated the associations between the parameters of flow-mediated vasodilatation (FMD) obtained by continuous measurement approaches and the presence of coronary artery disease (CAD) and the severity of coronary atherosclerosis. The subjects consisted of 282 consecutive patients who underwent coronary angiography (CAG) and in whom we could measure FMD. Using continuous measurement approaches, we measured FMD as the magnitude of the percentage change from brachial artery diameter from baseline to peak (bFMD), the maximum FMD rate calculated as the maximal slope of dilation (FMD-MDR), and the integrated FMD response calculated as the area under the dilation curve during the 60- and 120 s dilation periods (FMD-AUC60 and FMD-AUC120). We divided the patients into two groups, the CAD group and the non-CAD group, and defined the severity of coronary atherosclerosis according to the Gensini score. The CAD group showed significantly lower %FMD, FMD-MDR, FMD-AUC60, and FMD-AUC120. Gender, smoking, dyslipidemia (DL), and diabetes mellitus (DM), in addition to FMD-AUC120, were identified as significant independent variables that predicted the presence of CAD by a multivariate logistic regression. In addition, a multiple regression analysis indicated that gender, DL, and hypertension, in addition to FMD-AUC120, were predictors of the Gensini score. Finally, we defined the cutoff value of FMD-AUC120 for the prediction of CAD in all patients as 11.1 (sensitivity 0.582, specificity 0.652) by a receiver-operating characteristic (ROC) curve analysis. In conclusion, FMD-AUC120 as assessed by continuous measurement approaches may be a superior marker for evaluating the presence of CAD and the severity of coronary atherosclerosis.
authors.affiliation: a Department of Cardiology , Fukuoka University, School of Medicine , Fukuoka , Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Hitaka
authors.affiliation: a Department of Cardiology , Fukuoka University, School of Medicine , Fukuoka , Japan.|b Department of Molecular Cardiovascular Therapeutics , Fukuoka University School of Medicine , Fukuoka , Japan.
authors.forename: Shin-Ichiro
authors.initials: S
authors.lastname: Miura
authors.affiliation: a Department of Cardiology , Fukuoka University, School of Medicine , Fukuoka , Japan.
authors.forename: Rie
authors.initials: R
authors.lastname: Koyoshi
authors.affiliation: a Department of Cardiology , Fukuoka University, School of Medicine , Fukuoka , Japan.
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Suematsu
authors.affiliation: a Department of Cardiology , Fukuoka University, School of Medicine , Fukuoka , Japan.
authors.forename: Yuiko
authors.initials: Y
authors.lastname: Miyase
authors.affiliation: a Department of Cardiology , Fukuoka University, School of Medicine , Fukuoka , Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Norimatsu
authors.affiliation: a Department of Cardiology , Fukuoka University, School of Medicine , Fukuoka , Japan.
authors.forename: Sen
authors.initials: S
authors.lastname: Adachi
authors.affiliation: a Department of Cardiology , Fukuoka University, School of Medicine , Fukuoka , Japan.
authors.forename: Yuhei
authors.initials: Y
authors.lastname: Shiga
authors.affiliation: a Department of Cardiology , Fukuoka University, School of Medicine , Fukuoka , Japan.
authors.forename: Natsumi
authors.initials: N
authors.lastname: Morito
authors.affiliation: a Department of Cardiology , Fukuoka University, School of Medicine , Fukuoka , Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Nishikawa
authors.affiliation: a Department of Cardiology , Fukuoka University, School of Medicine , Fukuoka , Japan.|b Department of Molecular Cardiovascular Therapeutics , Fukuoka University School of Medicine , Fukuoka , Japan.
authors.forename: Keijiro
authors.initials: K
authors.lastname: Saku
mesh_terms: D000368:Aged; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000503:physiopathology; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003920:Diabetes Mellitus / Q000503:physiopathology; D050171:Dyslipidemias / Q000503:physiopathology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014664:Vasodilation / Q000502:physiology*
keywords: Continuous measurement approaches; Gensini score; coronary artery disease; coronary atherosclerosis; flow-mediated vasodilatation