title: Association Between ACE Gene Polymorphism and QT Dispersion in Patients with Acute Myocardial Infarction.
abstract: BACKGROUND
  Angiotensin converting enzyme (ACE) gene polymorphism is associated with high renin-angiotensin system causing myocardial fibrosis and ventricular repolarization abnormality. Based on these findings, this study was designed to determine the association between ACE gene insertion/deletion (I/D) polymorphism and QT dispersion after acute myocardial infarction (MI).
  
  
  OBJECTIVE
  The study included 108 patients with acute MI. Blood samples were obtained from all the patients for genomic DNA analysis. ECGs were recorded at baseline and at the end of a 6-month follow up. The OT dispersion was manually calculated.
  
  
  RESULTS
  The mean age of the patients was 57.5 ±9.9 years (ranging from 36 to 70). The patients with DD genotype showed longer QT dispersion than patients with II or DI genotype at the baseline, while at the end of the six-month follow up the patients with DI genotype showed longer QT dispersion than patients with DD or II genotypes. However, the magnitude of the QT dispersion prolongation was higher in patients carrying the ACE D allele than patients who were not carrying it, at baseline and at the end of six-month follow up (52.5 ±2.6 msn vs. 47.5±2.1 msn at baseline, 57±3.2 msn vs. 53±2.6 msn in months, P: 0.428 and P: 0.613, respectively).
  
  
  CONCLUSIONS
  Carriers of the D allele of ACE gene I/D polymorphism may be associated with QT dispersion prolongation in patients with MI.An interaction of QT dispersion and ACE gene polymorphism may be associated with an elevation of serum type I-C terminal pro-collagen concentration, possibly leading to myocardial fibrosis, and increased action potential duration.
authors.affiliation: Gazi Yasargil Education and Research Hospital, Cardiology, Diyarbakir, Turkey.
authors.forename: Zulkuf
authors.initials: Z
authors.lastname: Karahan
authors.affiliation: Gazi Yasargil Education and Research Hospital, Cardiology, Diyarbakir, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Ugurlu
authors.affiliation: Gazi Yasargil Education and Research Hospital, Cardiology, Diyarbakir, Turkey.
authors.forename: Berzal
authors.initials: B
authors.lastname: Ucaman
authors.affiliation: Gazi Yasargil Education and Research Hospital, Cardiology, Diyarbakir, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Veysel Ulug
authors.affiliation: Gazi Yasargil Education and Research Hospital, Cardiology, Diyarbakir, Turkey.
authors.forename: Ilyas
authors.initials: I
authors.lastname: Kaya
authors.affiliation: Gazi Yasargil Education and Research Hospital, Cardiology, Diyarbakir, Turkey.
authors.forename: Kemal
authors.initials: K
authors.lastname: Cevik
authors.affiliation: Gazi Yasargil Education and Research Hospital, Cardiology, Diyarbakir, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Sahin Adiyaman
authors.affiliation: Gazi Yasargil Education and Research Hospital, Cardiology, Diyarbakir, Turkey.
authors.forename: Onder
authors.initials: O
authors.lastname: Oztürk
authors.affiliation: Gazi Yasargil Education and Research Hospital, Cardiovascular Surgery, Diyarbakir, Turkey.
authors.forename: Hikmet
authors.initials: H
authors.lastname: Iyem
authors.affiliation: Gazi Yasargil Education and Research Hospital, Cardiovascular Surgery, Diyarbakir, Turkey.
authors.forename: Ferit
authors.initials: F
authors.lastname: Ozdemir
keywords: ACE gene polymorphism; Coronary artery disease (CAD); Myocardial infarction; QT dispersion