title: Randomized study of lafutidine vs lansoprazole in patients with mild gastroesophageal reflux disease.
abstract: OBJECTIVE
  To compare the clinical efficacy of the second-generation H2RA lafutidine with that of lansoprazole in Japanese patients with mild gastroesophageal reflux disease (GERD).
  
  
  METHODS
  Patients with symptoms of GERD and a diagnosis of grade A reflux esophagitis (according to the Los Angeles classification) were randomized to receive lafutidine (10 mg, twice daily) or lansoprazole (30 mg, once daily) for an initial 8 wk, followed by maintenance treatment comprising half-doses of the assigned drug for 24 wk. The primary endpoint was the frequency and severity of heartburn during initial and maintenance treatment. The secondary endpoints were the sum score of questions 2 and 3 in the Gastrointestinal Symptom Rating Scale (GSRS), and the satisfaction score.
  
  
  RESULTS
  Between April 2012 and March 2013, a total of 53 patients were enrolled, of whom 24 and 29 received lafutidine and lansoprazole, respectively. After 8 wk, the frequency and severity of heartburn was significantly reduced in both groups. However, lafutidine was significantly inferior to lansoprazole with regard to the severity of heartburn during initial and maintenance treatment (P = 0.016). The sum score of questions 2 and 3 in the GSRS, and satisfaction scores were also significantly worse in the lafutidine group than the lansoprazole group (P = 0.0068 and P = 0.0048, respectively).
  
  
  CONCLUSIONS
  The clinical efficacy of lafutidine was inferior to that of lansoprazole, even in Japanese patients with mild GERD.
authors.affiliation: Ryuta Takenaka, Department of Gastroenterology, Tsuyama Chuo Hospital, Tsuyama 708-0841, Japan.
authors.forename: Ryuta
authors.initials: R
authors.lastname: Takenaka
authors.affiliation: Ryuta Takenaka, Department of Gastroenterology, Tsuyama Chuo Hospital, Tsuyama 708-0841, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Okada
authors.affiliation: Ryuta Takenaka, Department of Gastroenterology, Tsuyama Chuo Hospital, Tsuyama 708-0841, Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Kawano
authors.affiliation: Ryuta Takenaka, Department of Gastroenterology, Tsuyama Chuo Hospital, Tsuyama 708-0841, Japan.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Komazawa
authors.affiliation: Ryuta Takenaka, Department of Gastroenterology, Tsuyama Chuo Hospital, Tsuyama 708-0841, Japan.
authors.forename: Fumiya
authors.initials: F
authors.lastname: Yoshinaga
authors.affiliation: Ryuta Takenaka, Department of Gastroenterology, Tsuyama Chuo Hospital, Tsuyama 708-0841, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Nagata
authors.affiliation: Ryuta Takenaka, Department of Gastroenterology, Tsuyama Chuo Hospital, Tsuyama 708-0841, Japan.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Inoue
authors.affiliation: Ryuta Takenaka, Department of Gastroenterology, Tsuyama Chuo Hospital, Tsuyama 708-0841, Japan.
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Komatsu
authors.affiliation: Ryuta Takenaka, Department of Gastroenterology, Tsuyama Chuo Hospital, Tsuyama 708-0841, Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Onogawa
authors.affiliation: Ryuta Takenaka, Department of Gastroenterology, Tsuyama Chuo Hospital, Tsuyama 708-0841, Japan.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Kushiyama
authors.affiliation: Ryuta Takenaka, Department of Gastroenterology, Tsuyama Chuo Hospital, Tsuyama 708-0841, Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Mukai
authors.affiliation: Ryuta Takenaka, Department of Gastroenterology, Tsuyama Chuo Hospital, Tsuyama 708-0841, Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Todo
authors.affiliation: Ryuta Takenaka, Department of Gastroenterology, Tsuyama Chuo Hospital, Tsuyama 708-0841, Japan.
authors.forename: Hideharu
authors.initials: H
authors.lastname: Okanobu
authors.affiliation: Ryuta Takenaka, Department of Gastroenterology, Tsuyama Chuo Hospital, Tsuyama 708-0841, Japan.
authors.forename: Noriaki
authors.initials: N
authors.lastname: Manabe
authors.affiliation: Ryuta Takenaka, Department of Gastroenterology, Tsuyama Chuo Hospital, Tsuyama 708-0841, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Tanaka
authors.affiliation: Ryuta Takenaka, Department of Gastroenterology, Tsuyama Chuo Hospital, Tsuyama 708-0841, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Haruma
authors.affiliation: Ryuta Takenaka, Department of Gastroenterology, Tsuyama Chuo Hospital, Tsuyama 708-0841, Japan.
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Kinoshita
mesh_terms: D000081:Acetamides / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004942:Esophagitis, Peptic / Q000188:drug therapy*; D005260:Female; D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D006356:Heartburn / Q000188:drug therapy*; D006635:Histamine H2 Antagonists / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007564:Japan; D064747:Lansoprazole / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D054328:Proton Pump Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D011725:Pyridines / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000081:Acetamides; D006635:Histamine H2 Antagonists; D010880:Piperidines; D054328:Proton Pump Inhibitors; D011725:Pyridines; D064747:Lansoprazole; C076948:lafutidine
keywords: Gastroesophageal reflux disease; Histamine receptor-2 antagonists; Los Angeles classification; Proton pump inhibitors