title: Adeninealkylresorcinol, the first alkylresorcinol tethered with nucleobase from Lasiodiplodia sp.
abstract: Adeninealkylresorcinol (1), an unusual alkylresorcinol with adenine-alkylresorcinol conjoined skeleton, was isolated from an endophytic fungus Lasiodiplodia sp. obtained from a traditional Chinese medicine Houttuynia cordata Thunb., together with three new biogenetically related compounds (2-4). Their structures were elucidated by comprehensive spectroscopic analysis, and the absolute configuration of 4 was determined by the modified Mosher's method and quantum chemical calculation. Among them, adeninealkylresorcinol (1) is the first alkylresorcinol tethered with nucleobase. In addition, the antioxidant, cytotoxic, and antimicrobial activities of 1-3 were evaluated.
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China.
authors.forename: Yu-Meng
authors.initials: YM
authors.lastname: Gao
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China.
authors.forename: Tian-Yu
authors.initials: TY
authors.lastname: Sun
authors.affiliation: Institute of Integrated Traditional Chinese and Western Medicine, Jinan University, Guangzhou 510632, China.
authors.forename: Min
authors.initials: M
authors.lastname: Ma
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China. Electronic address: chgdtong@163.com.
authors.forename: Guo-Dong
authors.initials: GD
authors.lastname: Chen
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China.
authors.forename: Zheng-Qun
authors.initials: ZQ
authors.lastname: Zhou
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China.
authors.forename: Chuan-Xi
authors.initials: CX
authors.lastname: Wang
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Hu
authors.affiliation: Institute of Integrated Traditional Chinese and Western Medicine, Jinan University, Guangzhou 510632, China.
authors.forename: Li-Guo
authors.initials: LG
authors.lastname: Chen
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China.
authors.forename: Xin-Sheng
authors.initials: XS
authors.lastname: Yao
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China. Electronic address: tghao@jnu.edu.cn.
authors.forename: Hao
authors.initials: H
authors.lastname: Gao
mesh_terms: D000225:Adenine / Q000737:chemistry* / Q000302:isolation & purification; D001203:Ascomycota / Q000737:chemistry*; D045744:Cell Line, Tumor; D004365:Drugs, Chinese Herbal; D052859:Houttuynia / Q000382:microbiology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D012118:Resorcinols / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D004365:Drugs, Chinese Herbal; D010636:Phenols; D010936:Plant Extracts; D012118:Resorcinols; C501911:antioxidant biofactor AOB; D000225:Adenine; C031389:resorcinol
keywords: Adeninealkylresorcinol; Alkylresorcinol; Antioxidant activity; Endophytic fungus; Houttuynia cordata; Lasiodiplodia sp.