title: Influence of the Cyclooxygenase-2 Gene -765G/C and -1195G/A Polymorphisms on Development of Ischemic Stroke.
abstract: BACKGROUND
  Many studies have investigated the association between the cyclooxygenase-2 (COX-2) gene polymorphism and ischemic stroke. However, results of these studies still remain controversial. To better explain the association between COX-2 polymorphisms (-765G/C and -1195G/A) and ischemic stroke risk, a meta-analysis was performed.
  
  
  METHODS
  Relevant studies were identified from 4 Chinese databases (Chinese Biological Medical Literature database, Chinese National Knowledge Infrastructure database, Chongqing VIP database, and Chinese WANFANG database), PUBMED and EMBASE prior to December 2015. The strength of association between COX-2 polymorphism and ischemic stroke was evaluated by the odds ratio (OR) with 95% confidence interval (CI). Inconsistency index (I(2)) and the Cochran's Q statistic were used to check heterogeneity. Publication bias was evaluated by funnel plots and Egger's regression test.
  
  
  RESULTS
  A total of 4086 ischemic stroke cases and 4747 controls were identified. Significant association between COX-2 -765G/C polymorphism and the risk of ischemic stroke was found in Brazilians and the African-Americans. The OR of (CC+GC versus GG) for the Brazilians and African-Americans were (6.328, 95% CI = 2.295-17.448) and (1.644, 95% CI = 1.060-2.551). In addition, the recessive model of the Brazilians gave an OR of 3.621 (95% CI: 1.519-8.630). Furthermore, the (GC versus GG) and the allele model of the African-Americans were (OR: 1.615, 95% CI = 1.015-2.572) and (OR: 1.422, 95% CI = 1.033-1.957). Significant association was also observed for COX-2 -1195G/A polymorphism in the subtypes of small vessel disease (SVD) of ischemic stroke.
  
  
  CONCLUSIONS
  Our study suggests that COX-2 -765G/C and -1195G/A polymorphisms may contribute to susceptibility of ischemic stroke, specifically in Brazilians and the African-Americans, and those of SVD.
authors.affiliation: Guangdong Province Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
authors.forename: Guangliang
authors.initials: G
authors.lastname: Wu
authors.affiliation: Ruikang Hospital Affiliated of Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Cai
authors.affiliation: Guangdong Province Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
authors.forename: Haobin
authors.initials: H
authors.lastname: Cai
authors.affiliation: The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Chen
authors.affiliation: First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Tan
authors.affiliation: Zhu Hai Blue Ocean Strategy Medical Center, Zhuhai, Guangdong, China.
authors.forename: Xiurong
authors.initials: X
authors.lastname: Qin
authors.affiliation: Guangdong Province Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China. Electronic address: caiyfengtg@163.com.
authors.forename: Yefeng
authors.initials: Y
authors.lastname: Cai
mesh_terms: D001741:Black or African American; D002545:Brain Ischemia / Q000150:complications* / Q000235:genetics*; D001938:Brazil; D002681:China; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D051546:Cyclooxygenase 2 / Q000235:genetics*; D004252:DNA Mutational Analysis; D016206:Databases, Bibliographic / Q000706:statistics & numerical data; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D015201:Meta-Analysis as Topic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D020521:Stroke / Q000209:etiology* / Q000235:genetics*
chemical_list: D051546:Cyclooxygenase 2
keywords: -1195G/A; -765G/C; COX-2; ischemic stroke