title: Sphingosine 1-phosphate signaling impacts lymphocyte migration, inflammation and infection.
abstract: Sphingosine 1-phosphate (S1P) is a sphingosine containing lipid intermediate obtained from ceramide. S1P is known to be an important signaling molecule and plays multiple roles in the context of immunity. This lysophospholipid binds and activates G-protein-coupled receptors (GPCRs) known as S1P receptors 1-5 (S1P1-5). Once activated, these GPCRs mediate signaling that can lead to alterations in cell proliferation, survival or migration, and can also have other effects such as promoting angiogenesis. In this review, we will present evidence demonstrating a role for S1P in lymphocyte migration, inflammation and infection, as well as in cancer. The therapeutic potential of targeting S1P receptors, kinases and lyase will also be discussed.
authors.affiliation: Department of Microbiology and Immunology, University of Maryland School of Medicine and the Marlene and Stewart Greenebaum Cancer Center, 685 W Baltimore St., Baltimore, MD 21201, USA.
authors.forename: Irina V
authors.initials: IV
authors.lastname: Tiper
authors.affiliation: Department of Microbiology and Immunology, University of Maryland School of Medicine and the Marlene and Stewart Greenebaum Cancer Center, 685 W Baltimore St., Baltimore, MD 21201, USA.
authors.forename: James E
authors.initials: JE
authors.lastname: East
authors.affiliation: Department of Microbiology and Immunology, University of Maryland School of Medicine and the Marlene and Stewart Greenebaum Cancer Center, 685 W Baltimore St., Baltimore, MD 21201, USA.
authors.forename: Priyanka B
authors.initials: PB
authors.lastname: Subrahmanyam
authors.affiliation: Department of Microbiology and Immunology, University of Maryland School of Medicine and the Marlene and Stewart Greenebaum Cancer Center, 685 W Baltimore St., Baltimore, MD 21201, USA twebb@som.umaryland.edu.
authors.forename: Tonya J
authors.initials: TJ
authors.lastname: Webb
mesh_terms: D000818:Animals; D002634:Chemotaxis, Leukocyte / Q000276:immunology*; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D000068876:Fingolimod Hydrochloride / Q000494:pharmacology; D019337:Hematologic Neoplasms / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism; D054884:Host-Pathogen Interactions; D006801:Humans; D007107:Immune System / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D007166:Immunosuppressive Agents / Q000494:pharmacology; D007239:Infections / Q000209:etiology* / Q000378:metabolism*; D007249:Inflammation / Q000209:etiology* / Q000378:metabolism*; D008214:Lymphocytes / Q000276:immunology* / Q000378:metabolism*; D008246:Lysophospholipids / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D016207:Cytokines; D007166:Immunosuppressive Agents; D008246:Lysophospholipids; D014157:Transcription Factors; C060506:sphingosine 1-phosphate; D000068876:Fingolimod Hydrochloride; D013110:Sphingosine
keywords: FTY720; S1P; lymphocyte trafficking; sphingosine