title: Serum amyloid A regulates monopoiesis in hyperlipidemic Ldlr(-/-) mice.
abstract: We previously showed that feeding a Western-type diet (WTD) to Ldlr(-/-) mice lacking serum amyloid A (SAA) (Saa(-/-) Ldlr(-/-) mice), the level of total blood monocytes was higher than in Ldlr(-/-) mice. In this investigation we demonstrate that higher levels of bone marrow monocytes and macrophage-dendritic cell progenitor (MDP) cells were found in WTD-fed Saa(-/-) Ldlr(-/-) mice compared to Ldlr(-/-) mice and lower levels of GMP cells and CMP cells in Ldlr(-/-) mice. These data indicate that SAA regulates the level of bone marrow monocytes and their myeloid progenitors in hyperlipidemic Ldlr(-/-) mice.
authors.affiliation: Molecular Pathogenesis and Molecular Medicine Graduate Program, University of Chicago, IL, USA.
authors.forename: Paulette A
authors.initials: PA
authors.lastname: Krishack
authors.affiliation: Department of Pathology, University of Chicago, IL, USA.
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Sontag
authors.affiliation: Molecular Pathogenesis and Molecular Medicine Graduate Program, University of Chicago, IL, USA.|Department of Pathology, University of Chicago, IL, USA.
authors.forename: Godfrey S
authors.initials: GS
authors.lastname: Getz
authors.affiliation: Molecular Pathogenesis and Molecular Medicine Graduate Program, University of Chicago, IL, USA.|Department of Pathology, University of Chicago, IL, USA.
authors.forename: Catherine A
authors.initials: CA
authors.lastname: Reardon
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000097:blood / Q000235:genetics; D001853:Bone Marrow / Q000378:metabolism; D016026:Bone Marrow Transplantation; D003713:Dendritic Cells / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D006951:Hyperlipoproteinemias / Q000097:blood / Q000235:genetics* / Q000473:pathology; D008264:Macrophages / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D009000:Monocytes / Q000378:metabolism / Q000473:pathology; D022423:Myeloid Cells / Q000378:metabolism; D011973:Receptors, LDL / Q000235:genetics*; D000685:Serum Amyloid A Protein / Q000235:genetics / Q000378:metabolism*
chemical_list: D011973:Receptors, LDL; D000685:Serum Amyloid A Protein
keywords: Western-type diet; monocytes; monopoiesis; serum amyloid A; stem cells