title: Neointimal coverage on acute vessel wall injuries after stenting: 6-month follow-up study.
abstract: BACKGROUND
  Stent implantation often creates local vessel wall injuries which can be characterized in detail by optical coherence tomography (OCT). Little is known about the neointimal coverage at these areas. We aimed to evaluate neointimal coverage of vessel wall injuries area associated with stent implantation.
  
  
  METHODS
  We retrospectively selected patients implanted with sirolimus-eluting stents (SES) having excellent OCT images immediately after stent implantation and at the 6-month follow-up. All OCT cross-sectional images were divided into three groups: intra-stent tissue prolapse (ISTP) areas, intra-stent dissection ﬂaps (ISDF) areas, and non-injuried areas. The neointimal coverage in included sections was evaluated at 6 months follow-up.
  
  
  RESULTS
  Finally, 1690 cross-sectional images in 74 stents were analyzed totally. Among which, 240 images (14.20%) involved ISTP areas, 124 images (7.34%) at ISDF areas, and 1326 images (78.46%) at non-injuried areas. All ISTP and ISDF were disappeared at six months follow-up, Neointimal thickness at ISTP and ISDF areas increased significantly compared to the one in non-injuried areas (97.4±40.3μm vs. 68.4±47.6μm, P<0.001; 92.7±49.8μm vs. 68.4±47.6μm, P<0.001). Mean neointimal area of ISTP and ISDF areas was almost the same (0.8±0.3 mm2), which both had a significant difference compared to mean neointimal area (0.6±0.4mm2) at non-injuried areas (p1<0.001, p2=0.006).
  
  
  CONCLUSIONS
  Intra-stent tissue prolapse and intra-stent dissection ﬂaps have benign clinical course up to 6 months. The areas with these local complications, however, have greater neointimal hyperplasia compared to the non-injuried areas.
authors.affiliation: Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Xingtao
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Cardiac Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Hang
authors.initials: H
authors.lastname: Lv
authors.affiliation: Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Xuedong
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Guang
authors.initials: G
authors.lastname: Yang
authors.affiliation: Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Yu
authors.affiliation: Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China - jingbohou@163.com.
authors.forename: Jingbo
authors.initials: J
authors.lastname: Hou
mesh_terms: D001808:Blood Vessels / Q000000981:diagnostic imaging / Q000293:injuries* / Q000473:pathology*; D054855:Drug-Eluting Stents / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D058426:Neointima / Q000000981:diagnostic imaging / Q000473:pathology*; D012189:Retrospective Studies; D020123:Sirolimus / Q000008:administration & dosage / Q000627:therapeutic use; D013524:Surgical Flaps; D041623:Tomography, Optical Coherence
chemical_list: D007166:Immunosuppressive Agents; D020123:Sirolimus