title: Regulation of cardiac metabolism and function by lipogenic factors.
abstract: The heart has a limited capacity for lipogenesis and de novo lipid synthesis. However, expression of lipogenic genes in cardiomyocytes is unexpectedly high. Recent studies showed that lipogenic genes are important factors regulating cardiac metabolism and function. Long chain fatty acids are a major source of ATP required for proper heart function, and under aerobic conditions, the heart derives 60-90% of the energy necessary for contractile function from fatty acid oxidation. On the other hand, cardiac lipid over-accumulation (e.g. ceramides, diacylglycerols) leads to heart dysfunction. Downregulation of the lipogenic genes' expression (e.g. sterol regulatory element binding protein 1, stearoyl-CoA desaturase, acetyl-CoA kwacarboxylase) decreased heart steatosis and cardiomyocyte apoptosis, improving systolic and diastolic function of the left ventricle. Lipogenic factors also regulate fatty acids and glucose utilization in the heart, underlining their important role in maintaining energetic homeostasis in pathological states. Fatty acid synthase, the enzyme catalyzing fatty acids de novo synthesis, affects cardiac calcium signaling through regulation of L-type calcium channel activity. Thus, a growing body of evidence suggests that the role of lipogenic genes in cardiomyocytes may be distinct from other tissues. Here, we review recent advances made in understanding the role of lipogenic genes in the control of heart metabolism and its involvement in the pathogenesis of lipotoxic cardiomyopathy.
authors.affiliation: Pracownia Molekularnej Biochemii Medycznej, Instytut Biologii Doświadczalnej im. M. Nenckiego PAN, Warszawa.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Bednarski
authors.affiliation: Pracownia Sygnałów Komórkowych i Zaburzeń Metabolicznych, Instytut Biologii Doświadczalnej im. M. Nenckiego PAN, Warszawa.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Pyrkowska
authors.affiliation: Pracownia Molekularnej Biochemii Medycznej, Instytut Biologii Doświadczalnej im. M. Nenckiego PAN, Warszawa.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Opasińska
authors.affiliation: Pracownia Molekularnej Biochemii Medycznej, Instytut Biologii Doświadczalnej im. M. Nenckiego PAN, Warszawa.
authors.forename: Paweł
authors.initials: P
authors.lastname: Dobrzyń
mesh_terms: D000818:Animals; D020746:Calcium Channels, L-Type / Q000378:metabolism; D064429:Fatty Acid Synthases; D005227:Fatty Acids / Q000378:metabolism; D015870:Gene Expression; D006321:Heart / Q000502:physiology*; D006801:Humans; D050155:Lipogenesis; D008929:Mitochondria, Heart / Q000378:metabolism*; D010084:Oxidation-Reduction; D013230:Stearoyl-CoA Desaturase / Q000378:metabolism
chemical_list: D020746:Calcium Channels, L-Type; D005227:Fatty Acids; D013230:Stearoyl-CoA Desaturase; D064429:Fatty Acid Synthases