title: Does salpingectomy have a deleterious impact on ovarian response in in vitro fertilization cycles?
abstract: OBJECTIVE
  To investigate the impact of salpingectomy in patients with IVF treatment on ovarian response.
  
  
  METHODS
  Meta-analysis.
  
  
  METHODS
  Not applicable.
  
  
  METHODS
  Patients under treatment for infertility, during the cycles before and after treatment by salpingectomy for hydrosalpinx or ectopic pregnancy.
  
  
  METHODS
  PubMed, MEDLINE, EMBASE databases, and CENTRAL in Cochrane Library up to July 2015. Either a fixed- or a random-effects model was used to calculate the overall combined risk estimates. The subgroup analysis was planned a priori before data were collected and analyzed.
  
  
  METHODS
  The amount of gonadotropin administered, the peak E2level, the number of oocytes retrieved, and the number of pregnancies.
  
  
  RESULTS
  After the final screening, 12 of the studies were retrospective and six were prospective. In this meta-analysis, 1,482 patients were enrolled, including a total of 657 patients with salpingectomy and 825 without salpingectomy. The comparisons before and after salpingectomy of the peak E2level (standardized mean difference [SMD] = -0.182; 95% confidence interval [CI], -0.166, 0.101; I2, 85.45%), the total gonadotropin dose used for stimulation (SMD = 0.127; 95% CI, -0.054 0.308; I2, 84.49%), and number of oocytes retrieved (SMD = -0.060; 95% CI, -0.189, 0.070; I2, 63.93%) did not reveal any significant differences. The number of pregnancies before and after salpingectomy did not differ significantly (odds ratio [OR] = 1.180; 95% CI, 0.854, 1.630; I2, 34.01%).
  
  
  CONCLUSIONS
  Salpingectomy in infertile patients does not have any negative effect on their subsequent fertility treatment, but further studies should be performed before this result can be considered definitive.
authors.affiliation: Department of Obstetrics and Gynecology, Sanggye Paik Hospital, Inje University School of Medicine, Seoul, South Korea.
authors.forename: Sang-Hee
authors.initials: SH
authors.lastname: Yoon
authors.affiliation: Department of Obstetrics and Gynecology, Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, South Korea.
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Lee
authors.affiliation: Department of Obstetrics and Gynecology, Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, South Korea.
authors.forename: Soo-Nyung
authors.initials: SN
authors.lastname: Kim
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Ewha Women's University, Seoul, South Korea.
authors.forename: Hye Won
authors.initials: HW
authors.lastname: Chung
authors.affiliation: Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.
authors.forename: So Yun
authors.initials: SY
authors.lastname: Park
authors.affiliation: Department of Obstetrics and Gynecology, Sanggye Paik Hospital, Inje University School of Medicine, Seoul, South Korea. Electronic address: morula3@gmail.com.
authors.forename: Chulmin
authors.initials: C
authors.lastname: Lee
mesh_terms: D015415:Biomarkers / Q000097:blood; D004958:Estradiol / Q000097:blood; D005260:Female; D005298:Fertility; D005300:Fertility Agents, Female / Q000009:adverse effects / Q000627:therapeutic use*; D005307:Fertilization in Vitro / Q000009:adverse effects; D006801:Humans; D007247:Infertility, Female / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D016017:Odds Ratio; D054315:Oocyte Retrieval; D010053:Ovary / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D010060:Ovulation / Q000187:drug effects*; D010062:Ovulation Induction / Q000009:adverse effects / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D018570:Risk Assessment; D012307:Risk Factors; D058994:Salpingectomy / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D005300:Fertility Agents, Female; D004958:Estradiol
keywords: Salpingectomy; in vitro fertilization; ovarian response