title: Associations Between Cardio-Ankle Vascular Index and Aortic Structure and Sclerosis Using Multidetector Computed Tomography.
abstract: Aortic pulse wave velocity (PWV) has been accepted as the gold standard for arterial stiffness measurement. However, PWV depends on blood pressure (BP). To eliminate the BP dependency of PWV, the cardio-ankle vascular index (CAVI) was developed. This study aimed to define the relationship between CAVI and aortic atherosclerosis or structure on multidetector computed tomography (MDCT). Patients with (n = 49) or without (n = 49) coronary artery disease were studied. The lumen and vessel diameters and wall thickness were calculated from the cross-sectional area at the pulmonary bifurcation level by 64-slice MDCT. The CAVI was measured within 3 days before MDCT. Multivariate analysis showed that the vessel diameter of the ascending and descending aorta on MDCT depends on age, body surface area, and diastolic BP. The CAVI significantly correlated with the vessel diameter ( r = .453) and wall thickness ( r = .387) of the thoracic descending aorta ( P < .001, respectively). The CAVI was an independent predictor of the descending aortic wall thickness on multiple stepwise regression analysis. These data suggest that CAVI, a simple index, is useful for evaluating thoracic aortic atherosclerosis.
authors.affiliation: 1 Department of Cardiology and Nephrology, Dokkyo Medical University, Mibu, Tochigi, Japan.
authors.forename: Shigeo
authors.initials: S
authors.lastname: Horinaka
authors.affiliation: 1 Department of Cardiology and Nephrology, Dokkyo Medical University, Mibu, Tochigi, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yagi
authors.affiliation: 1 Department of Cardiology and Nephrology, Dokkyo Medical University, Mibu, Tochigi, Japan.
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Fukushima
authors.affiliation: 1 Department of Cardiology and Nephrology, Dokkyo Medical University, Mibu, Tochigi, Japan.
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Shibata
authors.affiliation: 1 Department of Cardiology and Nephrology, Dokkyo Medical University, Mibu, Tochigi, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takeshima
authors.affiliation: 1 Department of Cardiology and Nephrology, Dokkyo Medical University, Mibu, Tochigi, Japan.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Ishimitsu
mesh_terms: D000368:Aged; D000842:Ankle / Q000098:blood supply*; D001013:Aorta, Thoracic / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001018:Aortic Diseases / Q000000981:diagnostic imaging* / Q000503:physiopathology; D050197:Atherosclerosis / Q000000981:diagnostic imaging* / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D063177:Pulse Wave Analysis; D011857:Radiographic Image Interpretation, Computer-Assisted; D012307:Risk Factors; D059289:Vascular Stiffness
chemical_list: D015415:Biomarkers
keywords: atherosclerosis; cardio–ankle vascular index; multidetector computed tomography; thoracic aortic structure