title: Caesalpinone A, a new type of gorgonane sesquiterpenoid containing an unprecedented 1,15-bridge, from the pods of Caesalpinia spinosa Kuntze.
abstract: Caesalpinone A (1), a new type of gorgonane sesquiterpenoid containing an unprecedented 1,15-bridge, along with ten known sesquiterpenoids (2-11) were isolated from the pods of Caesalpinia spinosa Kuntze (Tara). The structure of caesalpinone A was elucidated based on its 1D and 2D NMR spectra. The absolute configuration of 1 was assigned by the comparison of the experimental and calculated electronic circular dichroism spectra. Compound 1 was evaluated for the inhibitory activities against five human tumor cell lines. The sesquiterpenoids of isodaucane skeleton and caryolane skeleton were isolated from Caesalpinia genus for the first time. Compounds 5-9 were firstly reported from Tara.
authors.affiliation: Faculty of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650050, China.
authors.forename: Weihua
authors.initials: W
authors.lastname: Mu
authors.affiliation: Faculty of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650050, China.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Tang
authors.affiliation: Faculty of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650050, China.
authors.forename: Yuanping
authors.initials: Y
authors.lastname: Li
authors.affiliation: Faculty of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650050, China.
authors.forename: Dongyang
authors.initials: D
authors.lastname: He
authors.affiliation: Faculty of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650050, China.
authors.forename: Ruijing
authors.initials: R
authors.lastname: Ma
authors.affiliation: Faculty of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650050, China. Electronic address: lqwang@ynnu.edu.cn.
authors.forename: Liqin
authors.initials: L
authors.lastname: Wang
mesh_terms: D029911:Caesalpinia / Q000737:chemistry*; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D015394:Molecular Structure; D012639:Seeds / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D004224:Diterpenes; D012717:Sesquiterpenes; C000609198:caesalpinone
keywords: Caesalpinia spinosa; Caesalpinone A; Sesquiterpenoid; Tara