title: Do human B-lymphocytes avoid aging until 60 years?
abstract: Broad changes in human innate and adaptive immunity are associated with advanced age. The age-related alteration of gene expression was reported for both T and B lymphocytes. We analysed the genome-wide expression profiles (n=20) of naive and whole B cell populations from young and early aged healthy donors under 60 years. We revealed large homogeneity of all analysed genome-wide expression profiles but did not identified any significant gene deregulation between young (30-45 years) and early aged healthy donors (50-60 years). We argue that B cells avoid the aging program on molecular level until 60 years of age. Our results demonstrate the potential of hematopoietic stem cells to generate uncompromised lymphocytes in early elderly. These are very encouraging findings for the general health and the immunity maintenance would not need any intervention to naive B cells. Rather, a suitable immune stimulation in healthy body environment warrants further research into aging of older elderly.
authors.affiliation: Department of Pathological Physiology, Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic.|Gamma-Delta T Cell Laboratory, University Hospital Brno, Brno, Czech Republic.
authors.forename: Andrea
authors.initials: A
authors.lastname: Knight
authors.affiliation: Department of Pathological Physiology, Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic.
authors.forename: Pavel
authors.initials: P
authors.lastname: Nemec
authors.affiliation: Department of Pathological Physiology, Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic.|Laboratory of Cancer Biology and Genetics, University Hospital Brno, Brno, Czech Republic.
authors.forename: Sona
authors.initials: S
authors.lastname: Bretzova
authors.affiliation: Department of Pathological Physiology, Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic.|Laboratory of Cancer Biology and Genetics, University Hospital Brno, Brno, Czech Republic.
authors.forename: Lucie
authors.initials: L
authors.lastname: Valkova
authors.affiliation: Department of Pathological Physiology, Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic.|Laboratory of Cancer Biology and Genetics, University Hospital Brno, Brno, Czech Republic.
authors.forename: Marketa
authors.initials: M
authors.lastname: Kolmanova
authors.affiliation: Department of Pathological Physiology, Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic.|Laboratory of Cancer Biology and Genetics, University Hospital Brno, Brno, Czech Republic.
authors.forename: Renata
authors.initials: R
authors.lastname: Vytopilova
authors.affiliation: Department of Pathological Physiology, Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic.|Laboratory of Cancer Biology and Genetics, University Hospital Brno, Brno, Czech Republic.
authors.forename: Marek
authors.initials: M
authors.lastname: Havelka
authors.affiliation: Department of Clinical Haematology, University Hospital Brno, Brno, Czech Republic.
authors.forename: Pavla
authors.initials: P
authors.lastname: Vsianska
authors.affiliation: Department of Clinical Haematology, University Hospital Brno, Brno, Czech Republic.
authors.forename: Lucie
authors.initials: L
authors.lastname: Rihova
authors.affiliation: Department of Internal Medicine, Haematology and Oncology, University Hospital Brno, Brno, Czech Republic.
authors.forename: Marta
authors.initials: M
authors.lastname: Krejci
authors.affiliation: Department of Pathological Physiology, Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic.|Laboratory of Cancer Biology and Genetics, University Hospital Brno, Brno, Czech Republic.
authors.forename: Martin
authors.initials: M
authors.lastname: Piskacek
mesh_terms: D056704:Adaptive Immunity / Q000235:genetics / Q000276:immunology*; D000328:Adult; D000375:Aging / Q000235:genetics / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D005260:Female; D020869:Gene Expression Profiling / Q000379:methods; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics / Q000276:immunology*; D053699:Interleukin-7 Receptor alpha Subunit / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D059467:Transcriptome / Q000235:genetics / Q000276:immunology*
chemical_list: C000620371:IL7R protein, human; D053699:Interleukin-7 Receptor alpha Subunit
keywords: B cell; GEP; Gerotarget; IL7R; aging; naive B cells