title: Consumption of Fresh Yellow Onion Ameliorates Hyperglycemia and Insulin Resistance in Breast Cancer Patients During Doxorubicin-Based Chemotherapy: A Randomized Controlled Clinical Trial.
abstract: Doxorubicin has been found to be associated with insulin resistance in animal models. Onion, a so-called functional food, is noted to affect the insulin signaling pathway of diabetes in vitro. To our knowledge, this is the first study to investigate the effects of consuming fresh yellow onions on insulin-related indices compared with a low-onion-containing diet among breast cancer (BC) patients treated with doxorubicin.
  
  
  
  This parallel-design, randomized, triple-blind, controlled clinical trial was conducted on 56 eligible BC patients (aged 30-63 years), diagnosed with invasive ductal carcinoma. Following their second cycle of chemotherapy, subjects were assigned in a stratified-random allocation to receive body mass index-dependent 100 to 160 g/d of onion as high onion group (HO; n = 28) or 30 to 40 g/d small onions in low onion group (LO; n = 28) for 8 weeks intervention. Participants, care givers, and those who assessed laboratory analyses were blinded to the assignments (IRCT Registry No.: IRCT2012103111335N1).
  
  
  
  The compliance level of participants in the analysis was as high as 87.85%. A total of 23 available cases was analyzed in each group. The daily use of HO resulted in a significant decrease in serum fasting blood glucose and insulin levels in comparison with LO, over the period of study ( P < .001). Posttreatment with HO showed a significant decrease in homeostasis model of assessment-insulin resistance relative to changes in the LO group ( P < .05). A comparison of the changes that occurred throughout pre- and postdose treatments indicated improved quantitative insulin sensitivity check index ( P < .05) and controls on C-peptide in the HO group ( P < .05).
  
  
  
  The present study demonstrated the effectiveness of onion to ameliorate hyperglycemia and insulin resistance in BC during doxorubicin-based chemotherapy.
authors.affiliation: 1 Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Farnaz
authors.initials: F
authors.lastname: Jafarpour-Sadegh
authors.affiliation: 1 Tabriz University of Medical Sciences, Tabriz, Iran.|2 Nour-Nejat Hospital, Tabriz, Iran.
authors.forename: Vahid
authors.initials: V
authors.lastname: Montazeri
authors.affiliation: 1 Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Adili
authors.affiliation: 1 Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Esfehani
authors.affiliation: 1 Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Mohammad-Reza
authors.initials: MR
authors.lastname: Rashidi
authors.affiliation: 1 Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Saeed
authors.initials: S
authors.lastname: Pirouzpanah
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000187:drug effects; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000188:drug therapy*; D004032:Diet / Q000379:methods; D004317:Doxorubicin / Q000009:adverse effects* / Q000627:therapeutic use*; D005260:Female; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D006943:Hyperglycemia / Q000188:drug therapy*; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology*; D008875:Middle Aged; D019697:Onions / Q000737:chemistry*; D028321:Plant Preparations / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D028321:Plant Preparations; D004317:Doxorubicin
keywords: breast cancer; doxorubicin; insulin resistance; intervention; onion