title: Hippocampal Attractor Dynamics Predict Memory-Based Decision Making.
abstract: Memories are thought to be retrieved by attractor dynamics if a given input is sufficiently similar to a stored attractor state [1-5]. The hippocampus, a region crucial for spatial navigation [6-12] and episodic memory [13-18], has been associated with attractor-based computations [5, 9], receiving support from the way rodent place cells "remap" nonlinearly between spatial representations [19-22]. In humans, nonlinear response patterns have been reported in perceptual categorization tasks [23-25]; however, it remains elusive whether human memory retrieval is driven by attractor dynamics and what neural mechanisms might underpin them. To test this, we used a virtual reality [7, 11, 26-28] task where participants learned object-location associations within two distinct virtual reality environments. Participants were subsequently exposed to four novel intermediate environments, generated by linearly morphing the background landscapes of the familiar environments, while tracking fMRI activity. We show that linear changes in environmental context cause linear changes in activity patterns in sensory cortex but cause dynamic, nonlinear changes in both hippocampal activity pattern and remembered locations. Furthermore, the sigmoidal response in the hippocampus scaled with the strength of the sigmoidal pattern in spatial memory. These results indicate that mnemonic decisions in an ambiguous novel context relate to putative attractor dynamics in the hippocampus, which support the dynamic remapping of memories.
authors.affiliation: Donders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 EN Nijmegen, the Netherlands; Laboratory of Neuropsychology, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA. Electronic address: ben.steemers@nih.gov.
authors.forename: Ben
authors.initials: B
authors.lastname: Steemers
authors.affiliation: Donders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 EN Nijmegen, the Netherlands.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Vicente-Grabovetsky
authors.affiliation: Research Department of Cell and Developmental Biology, UCL, Gower Street, London WC1E 6BT, UK.
authors.forename: Caswell
authors.initials: C
authors.lastname: Barry
authors.affiliation: Donders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 EN Nijmegen, the Netherlands.
authors.forename: Peter
authors.initials: P
authors.lastname: Smulders
authors.affiliation: Donders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 EN Nijmegen, the Netherlands.
authors.forename: Tobias Navarro
authors.initials: TN
authors.lastname: Schröder
authors.affiliation: UCL Institute of Cognitive Neuroscience, 17 Queen Square, London WC1N 3AZ, UK; UCL Institute of Neurology, Queen Square, London WC1 3BG, UK.
authors.forename: Neil
authors.initials: N
authors.lastname: Burgess
authors.affiliation: Donders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 EN Nijmegen, the Netherlands. Electronic address: christian.doeller@donders.ru.nl.
authors.forename: Christian F
authors.initials: CF
authors.lastname: Doeller
mesh_terms: D000293:Adolescent; D003657:Decision Making; D005260:Female; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D061212:Memory, Episodic; D008959:Models, Neurological; D066191:Sensorimotor Cortex / Q000503:physiopathology*; D065852:Spatial Memory; D055815:Young Adult