title: Splenic infarction associated with acute infectious mononucleosis due to Epstein-Barr virus infection.
abstract: The purpose of this study was to report a case of a previously healthy 20-year-old woman diagnosed with splenic infarction following infectious mononucleosis (IM) by Epstein-Barr virus (EBV) infection and to perform the first systematic review of the clinical characteristics of splenic infarction associated with IM. A systematic review was conducted using English, French, and Japanese literatures of splenic infarction associated with IM due to EBV infection published between 1961 and 2015 in PubMed Medline. A total of 19 cases were extracted from the collected articles. Left upper quadrant (LUQ) pain was observed in 15 (79%) patients. Splenectomy was performed in five (26%) cases, among which four patients presented with stable vital signs. Splenic rupture was accompanied in two (10%) patients. The median time from the onset of IM symptoms to the diagnosis of splenic infarction was 5 days (range, 1-25 days). Fourteen (74%) of 19 patients experienced improvement through medical treatment, and there were no deaths. Splenic infarction associated with IM due to EBV infection can show a favorable clinical outcome after medical treatment. Clinicians should consider the possibility of splenic infarction when patients with IM experience LUQ pain. J. Med. Virol. 89:332-336, 2017. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Department of Internal Medicine, Chonbuk National University Hospital, Jeonju, Republic of Korea.
authors.forename: Dae-Hyuk
authors.initials: DH
authors.lastname: Heo
authors.affiliation: Department of Internal Medicine, Chonbuk National University Hospital, Jeonju, Republic of Korea.
authors.forename: Dae-Youb
authors.initials: DY
authors.lastname: Baek
authors.affiliation: Department of Internal Medicine, Chonbuk National University Hospital, Jeonju, Republic of Korea.
authors.forename: Sang-Min
authors.initials: SM
authors.lastname: Oh
authors.affiliation: Department of Internal Medicine, Chonbuk National University Hospital, Jeonju, Republic of Korea.
authors.forename: Joo-Hee
authors.initials: JH
authors.lastname: Hwang
authors.affiliation: Department of Internal Medicine, Chonbuk National University Hospital, Jeonju, Republic of Korea.|Research Institute of Clinical Medicine of Chonbuk National University, Chonbuk National University Hospital, Jeonju, Republic of Korea.
authors.forename: Chang-Seop
authors.initials: CS
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Chonbuk National University Hospital, Jeonju, Republic of Korea.|Research Institute of Clinical Medicine of Chonbuk National University, Chonbuk National University Hospital, Jeonju, Republic of Korea.
authors.forename: Jeong-Hwan
authors.initials: JH
authors.lastname: Hwang
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D007244:Infectious Mononucleosis / Q000150:complications* / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D013159:Splenic Infarction / Q000209:etiology* / Q000473:pathology*; D055815:Young Adult
keywords: Epstein-Barr virus; infectious mononucleosis; splenic infarction