title: Applications of nanoparticle drug delivery systems for the reversal of multidrug resistance in cancer.
abstract: Multidrug resistance (MDR) to chemotherapy presents a major obstacle in the treatment of cancer patients, which directly affects the clinical success rate of cancer therapy. Current research aims to improve the efficiency of chemotherapy, whilst reducing toxicity to prolong the lives of cancer patients. As with good biocompatibility, high stability and drug release targeting properties, nanodrug delivery systems alter the mechanism by which drugs function to reverse MDR, via passive or active targeting, increasing drug accumulation in the tumor tissue or reducing drug elimination. Given the potential role of nanodrug delivery systems used in multidrug resistance, the present study summarizes the current knowledge on the properties of liposomes, lipid nanoparticles, polymeric micelles and mesoporous silica nanoparticles, together with their underlying mechanisms. The current review aims to provide a reliable basis and useful information for the development of new treatment strategies of multidrug resistance reversal using nanodrug delivery systems.
authors.affiliation: Department of Traditional Chinese Medicine, College of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, P.R. China.
authors.forename: Yinghong
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Pathology and Molecular Medicine, Division of Cancer Biology and Genetics, Queen's University Cancer Research Institute, Kingston, ON K7L 3N6, Canada.
authors.forename: Susan P C
authors.initials: SP
authors.lastname: Cole
authors.affiliation: Department of Biological Sciences, College of Life Sciences, Liaoning University, Shenyang, Liaoning 110036, P.R. China.
authors.forename: Tiange
authors.initials: T
authors.lastname: Cai
authors.affiliation: Department of Traditional Chinese Medicine, College of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, P.R. China; Cancer Institute of Jinan University, Guangzhou, Guangdong 510632, P.R. China.
authors.forename: Y U
authors.initials: YU
authors.lastname: Cai
keywords: MDR; MSNs; NLC; PLN; SLN; applications; cancer; liposomes; nanoparticle drug delivery system; phospholipid bilayer; polymeric micelles