title: Anaplastic lymphoma kinase-positive squamous cell carcinoma of the lung: A case report.
abstract: It is widely known that echinoderm microtubule-associated protein-like 4 anaplastic lymphoma kinase (EML4-ALK) rearrangement mostly occurs in the adenocarcinoma subtype of non-small-cell lung cancer (NSCLC). Patients with squamous cell carcinoma harboring the ALK rearrangement are extremely rare. This is a case report of a squamous cell carcinoma patient with EML4-ALK rearrangement. An elderly man with a heavy smoking history presented with a mass lesion in the right main bronchus. Bronchoscopic biopsy of the tumor confirmed a diagnosis of squamous cell carcinoma, and it was proven to harbor ALK rearrangement, based on fluorescencein situhybridization, but not epidermal growth factor receptor mutations. The patient underwent radiation therapy, with a markedly favorable response. ALK-targeted treatment may be a viable option if disease progression occurs in such a case in the future.
authors.affiliation: Department of Thoracic Surgery, Yao Municipal Hospital, Yao, Osaka 581-0069, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Yamamoto
authors.affiliation: Department of Thoracic Surgery, Yao Municipal Hospital, Yao, Osaka 581-0069, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Kodama
authors.affiliation: Department of Thoracic Surgery, Yao Municipal Hospital, Yao, Osaka 581-0069, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Maniwa
authors.affiliation: Department of Pathology, Yao Municipal Hospital, Yao, Osaka 581-0069, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Takeda
authors.affiliation: Department of Surgery, Kishima Hospital Main Division, Yao, Osaka 581-0069, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kishima
keywords: anaplastic lymphoma kinase; lung cancer; squamous cell carcinoma