title: Is there any role of prolidase enzyme activity in the etiology of preeclampsia?
abstract: OBJECTIVE
  To evaluate a relationship between preeclampsia and prolidase enzyme activity.
  
  
  METHODS
  A prospective cohort study of 41 pregnant women diagnosed with preeclampsia and 31 healthy pregnant women as control group was selected at Harran University Hospital Department of Obstetrics and Gynecology. The prolidase enzyme activity was analyzed in maternal and umbilical cord plasma, amniotic fluid and placental and umbilical cord tissues by Chinard method in addition to maternal serum levels of lactate dehydrogenase (LDH), serum glutamate pyruvate transaminase (SGPT) and serum glutamate oxaloacetate transaminase (SGOT).
  
  
  RESULTS
  A significant relationship was found between plasma prolidase activity (635 ± 83 U/L) (p  = 0.007), umbilical cord plasma prolidase activity (610 ± 90 U/L) (p = 0.013), amniotic fluid prolidase activity (558 ± 100 U/L) (p  = 0.001), umbilical cord tissue prolidase activity (4248 ± 1675 U/gr protein) (p  = 0.013) and placental tissue prolidase activity (2116 ± 601 U/gr protein) (p  = 0.001) in preeclamptic group when compared to healthy pregnant women.
  
  
  CONCLUSIONS
  There is a strong correlation between prolidase enzyme activity and preeclampsia. Prolidase enzyme activity may play a role in preeclampsia.
authors.affiliation: a Department of Obstetrics and Gynecology Aydın , Aydın Obstetrics and Pediatrics Hospital , Aydın , Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Pehlivan
authors.affiliation: b Department of Obstetrics and Gynecology Aydın , Aydın Private Ege Liva Hospital , Aydın , Turkey.
authors.forename: Pelin
authors.initials: P
authors.lastname: Ozün Ozbay
authors.affiliation: c Department of Obstetrics and Gynecology , Bursa Yüksek İhtisas Training and Research Hospital , Bursa , Turkey.
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Temur
authors.affiliation: d Department of Obstetrics and Gynecology , Manisa Merkezefendi Hospital , Merkezefendi , Manisa , Turkey.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Yılmaz
authors.affiliation: e Faculty of Medicine , Department of Obstetrics and Gynecology , and.
authors.forename: Fatma Ferda
authors.initials: FF
authors.lastname: Verit
authors.affiliation: f Faculty of Medicine , Department of Clinical Biochemistry, Harran University , Sanliurfa , Turkey.
authors.forename: Nurten
authors.initials: N
authors.lastname: Aksoy
authors.affiliation: c Department of Obstetrics and Gynecology , Bursa Yüksek İhtisas Training and Research Hospital , Bursa , Turkey.
authors.forename: Engin
authors.initials: E
authors.lastname: Korkmazer
authors.affiliation: c Department of Obstetrics and Gynecology , Bursa Yüksek İhtisas Training and Research Hospital , Bursa , Turkey.
authors.forename: Emin
authors.initials: E
authors.lastname: Üstünyurt
mesh_terms: D000328:Adult; D000653:Amniotic Fluid / Q000201:enzymology; D016022:Case-Control Studies; D004150:Dipeptidases / Q000097:blood / Q000378:metabolism*; D005260:Female; D005312:Fetal Blood / Q000201:enzymology; D006801:Humans; D010920:Placenta / Q000201:enzymology*; D011225:Pre-Eclampsia / Q000201:enzymology* / Q000209:etiology; D011247:Pregnancy; D011446:Prospective Studies; D018709:Statistics, Nonparametric; D014470:Umbilical Cord / Q000201:enzymology
chemical_list: D004150:Dipeptidases; C022449:proline dipeptidase
keywords: Endothelial dysfunction; preeclampsia; pregnancy; prolidase enzyme activity; tissue and plasma