title: Lichenoid drug eruption caused by imatinib mesylate in a Chinese patient with gastrointestinal stromal tumor.
abstract: Imatinib mesylate, the first agent approved for the treatment of unresectable or metastatic gastrointestinal stromal tumor, is a tyrosine kinase inhibitor targeting (KIT) and the platelet-derived growth factor receptor-α and -β. However, imatinib administration can be accompanied by various adverse events. Here we report a case of Lichenoid drug eruption (LDE) that appeared 24 weeks after commencement of imatinib in a 73-year-old man with gastrointestinal stromal tumor (GIST). The skin lesions were distributed over his face, trunk and limbs, which improved only after discontinuation of imatinib therapy. To the best of our knowledge, this is the first report of imatinib-induced LDE in the Chinese population.
authors.forename: Jing-Ru
authors.initials: JR
authors.lastname: Luo
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Xiang
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Xiong
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D044466:Asian People; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy / Q000473:pathology; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D000068877:Imatinib Mesylate / Q000009:adverse effects* / Q000627:therapeutic use; D017512:Lichenoid Eruptions / Q000209:etiology*; D008297:Male
chemical_list: D000970:Antineoplastic Agents; D000068877:Imatinib Mesylate