title: Wnt/β-catenin pathway in tissue injury: roles in pathology and therapeutic opportunities for regeneration.
abstract: The Wnt/β-catenin pathway is an evolutionarily conserved set of signals with critical roles in embryonic and neonatal development across species. In mammals the pathway is quiescent in many organs. It is reactivated in response to injury and is reported to play complex and contrasting roles in promoting regeneration and fibrosis. We review the current understanding of the role of the Wnt/β-catenin pathway in injury of various mammalian organs and discuss the current advances and potential of Wnt inhibitory therapeutics toward promoting tissue regeneration and reducing fibrosis.-Bastakoty, D., Young, P. P. Wnt/β-catenin pathway in tissue injury: roles in pathology and therapeutic opportunities for regeneration.
authors.affiliation: Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA; and.
authors.forename: Dikshya
authors.initials: D
authors.lastname: Bastakoty
authors.affiliation: Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA; and Department of Internal Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA pampee.young@vanderbilt.edu.
authors.forename: Pampee P
authors.initials: PP
authors.lastname: Young
mesh_terms: D000818:Animals; D006801:Humans; D012038:Regeneration / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D051153:Wnt Proteins / Q000378:metabolism*; D060449:Wnt Signaling Pathway / Q000502:physiology*; D014945:Wound Healing / Q000502:physiology*; D051176:beta Catenin / Q000378:metabolism*
chemical_list: D051153:Wnt Proteins; D051176:beta Catenin
keywords: fibrosis; inhibitor; repair; scar; wound healing