title: Efficacy of echinocandins against murine infections by Diutina (Candida) rugosa.
abstract: Echinocandins are recommended as a first-line therapy for invasive candidiasis. Candida rugosa was recently transferred to the new genus Diutina. We have determined the in vitro killing kinetics of two echinocandins, anidulafungin, and caspofungin and their in vivo efficacy, administering doses of 5 or 10 mg/kg, and 1 or 5 mg/kg, respectively against 2 clinical strains of D. rugosa. Both drugs showed a fungicidal concentration-dependent activity and, in a neutropenic murine model of disseminated infection, were able to reduce tissue burden and to prolong survival of mice. These results suggest that both echinocandins could be useful to treat infections by this fungus when isolates show minimal inhibitory concentrations within the range of susceptibility for both drugs.
authors.affiliation: Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Tarragona, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Sanchis
authors.affiliation: Fungus Testing Laboratory, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
authors.forename: Deanna A
authors.initials: DA
authors.lastname: Sutton
authors.affiliation: Fungus Testing Laboratory, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
authors.forename: Nathan P
authors.initials: NP
authors.lastname: Wiederhold
authors.affiliation: Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Tarragona, Spain. Electronic address: josep.guarro@urv.cat.
authors.forename: Josep
authors.initials: J
authors.lastname: Guarro
authors.affiliation: Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Tarragona, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Capilla
mesh_terms: D000077612:Anidulafungin; D000825:Animal Structures / Q000382:microbiology; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000494:pharmacology; D000077336:Caspofungin; D015169:Colony Count, Microbial; D004195:Disease Models, Animal; D054714:Echinocandins / Q000008:administration & dosage* / Q000494:pharmacology; D016469:Fungemia / Q000188:drug therapy* / Q000382:microbiology*; D055666:Lipopeptides / Q000008:administration & dosage* / Q000494:pharmacology; D008297:Male; D051379:Mice; D004718:Saccharomycetales / Q000187:drug effects*; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077612:Anidulafungin; D000077336:Caspofungin
keywords: Anidulafungin; Animal model; Antifungals; Caspofungin; Diutina rugosa; Fungal infections