title: Zingiber miogareduces weight gain, insulin resistance and hepatic gluconeogenesis in diet-induced obese mice.
abstract: Zingiber miogais a perennial herb belonging to the ginger family (Zingiberaceae) that is used medicinally to treat cough and rheumatism in China and consumed throughout Japan. The aim of the present study was to investigate the anti-obesity effects ofZ. miogafollowing extraction with distilled water or 70% ethanol. In 3T3-L1 preadipocyte cells,Z. miogawater extract (ZMW) markedly inhibited adipogenesis, whereas the ethanol extract had no effect. In addition, we conducted ZMW feeding experiments (0.25 or 0.5% ZMW) in high-fat diet (HFD)-fed mice to examine the anti-obesity effects ofZ. mioga in vivo. Body weight and serum triglyceride and cholesterol levels significantly decreased in the HFD + ZMW 0.5% group. Notably, ZMW decreased liver weight but not adipose tissue weight. Furthermore, insulin resistance and hepatic mRNA expression of gluconeogenic genes, such as phosphoenolpyruvate carboxykinase and G6Pase, were improved in the HFD + ZMW 0.5% group. Furthermore, ZMW treatment decreased hepatic lipogenic gene expression; however, it did not alter adipogenesis in fat tissue, suggesting that ZMW inhibits hepatosteatosis through the suppression of lipogenesis. ZMW improved HFD-induced hepatic inflammation. Collectively, the present findings suggest that ZMW may serve as a new and promising strategy for the treatment of hepatosteatosis.
authors.affiliation: Department of Food Biotechnology, Korea University of Science and Technology, Seongnam, Gyeonggi 13539, Republic of Korea.
authors.forename: DA-Hye
authors.initials: DH
authors.lastname: Lee
authors.affiliation: Department of Food Biotechnology, Korea University of Science and Technology, Seongnam, Gyeonggi 13539, Republic of Korea; Metabolic Mechanism Research Group, Korea Food Research Institute, Seongnam, Gyeonggi 13539, Republic of Korea.
authors.forename: Jiyun
authors.initials: J
authors.lastname: Ahn
authors.affiliation: Metabolic Mechanism Research Group, Korea Food Research Institute, Seongnam, Gyeonggi 13539, Republic of Korea.
authors.forename: Young Jin
authors.initials: YJ
authors.lastname: Jang
authors.affiliation: Department of Food Biotechnology, Korea University of Science and Technology, Seongnam, Gyeonggi 13539, Republic of Korea; Metabolic Mechanism Research Group, Korea Food Research Institute, Seongnam, Gyeonggi 13539, Republic of Korea.
authors.forename: Tae-Youl
authors.initials: TY
authors.lastname: Ha
authors.affiliation: Department of Food Biotechnology, Korea University of Science and Technology, Seongnam, Gyeonggi 13539, Republic of Korea; Metabolic Mechanism Research Group, Korea Food Research Institute, Seongnam, Gyeonggi 13539, Republic of Korea.
authors.forename: Chang Hwa
authors.initials: CH
authors.lastname: Jung
keywords: Zingiber mioga; adipogenesis; hepatosteatosis; insulin resistance; lipogenesis