title: Advantages of L-3-[(18)F] fluoro-alpha-methyl tyrosine over 2-[(18)F]-fluoro-2-deoxyglucose in detecting liver metastasis during positron emission tomography scan.
abstract: OBJECTIVE
  We aimed to assess the usefulness of positron emission tomography (PET) using the amino acid tracer L-3-[18F] fluoro-alpha-methyl tyrosine (FAMT) in detecting metastatic liver lesions compared with 2-[18F]-fluoro-2-deoxyglucose (FDG).
  
  
  METHODS
  We included 24 patients with liver metastases who underwent both FDG-PET/computed tomography (CT) and FAMT-PET/CT. Maximum standardized uptake value (SUVmax) and tumor-to-liver parenchymal (T/L) ratio were analyzed to evaluate the correlation between FDG and FAMT uptakes in metastatic liver lesions; adenocarcinoma (AC, n = 21), squamous cell carcinoma (SCC, n = 23), neuroendocrine tumor (NET, n = 9), and carcinoid tumor (CAR, n = 6).
  
  
  RESULTS
  We detected 59 lesions on performing either FDG-PET or FAMT-PET. NETs had significantly lower T/L ratios for FAMT (median, 1.00; range, 0.86-1.34) compared with those for FDG (median 2.86; range 1.70-6.13, p < 0.01). CAR tumors tended to reveal lower T/L ratios for FDG (median 1.10; range 0.78-1.92) than those for FAMT (median 1.80; range 0.80-2.34). Comparison of T/L ratios of SCC and AC revealed that FAMT in the metastatic liver lesions of SCC was higher than those of AC (p < 0.05).
  
  
  CONCLUSIONS
  FAMT-PET could detect metastatic liver lesions from various cancers, except NET.
authors.affiliation: Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine, 3-39-22, Showa, Maebashi, Gunma 371-8511 Japan.
authors.forename: Sayaka
authors.initials: S
authors.lastname: Kodaira
authors.affiliation: Department of Molecular Imaging, Gunma University Graduate School of Medicine, 3-39-22, Showa, Maebashi, Gunma 371-8511 Japan.
authors.forename: Takahito
authors.initials: T
authors.lastname: Nakajima
authors.affiliation: Department of Molecular Imaging, Gunma University Graduate School of Medicine, 3-39-22, Showa, Maebashi, Gunma 371-8511 Japan.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Arisaka
authors.affiliation: Department of Molecular Imaging, Gunma University Graduate School of Medicine, 3-39-22, Showa, Maebashi, Gunma 371-8511 Japan.
authors.forename: Azusa
authors.initials: A
authors.lastname: Tokue
authors.affiliation: Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine, 3-39-22, Showa, Maebashi, Gunma 371-8511 Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Higuchi
authors.affiliation: Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine, 3-39-22, Showa, Maebashi, Gunma 371-8511 Japan.
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Tsushima
keywords: 2-[18F]-fluoro-2-deoxyglucose; L-3-[18F] fluoro-alpha-methyl tyrosine; Liver metastasis; Positron emission tomography