title: No evidence of disease activity in multiple sclerosis patients.
abstract: Multiple Sclerosis is a chronic inflammatory demyelinating disease that affects 2.5 million people in the world. NEDA (No evidence of disease Activity) -4 is a new concept related to absence of disease activity in the context of MS. It takes into account the following four parameters: relapses; disability progression; lesion load and brain atrophy. Areas covered: The purpose of this paper is to visit the new emerging concepts of NEDA. Although it is considered important and attractive, there is a lack of uniformity. Expert commentary: Although NEDA-4 embraces important markers of disease activity and degeneration, this definition is still evolving and other parameters apart from the loss of brain volume might be included, especially those related to disability, such as cognitive problems, visual function, fatigue and pain.
authors.affiliation: a Neurology Department , Federal Fluminense University , Rio de Janeiro , Brazil.
authors.forename: André Palma da Cunha
authors.initials: AP
authors.lastname: Matta
authors.affiliation: a Neurology Department , Federal Fluminense University , Rio de Janeiro , Brazil.
authors.forename: Osvaldo J M
authors.initials: OJ
authors.lastname: Nascimento
authors.affiliation: a Neurology Department , Federal Fluminense University , Rio de Janeiro , Brazil.
authors.forename: Ana Carolina Andorinho de F
authors.initials: AC
authors.lastname: Ferreira
authors.affiliation: a Neurology Department , Federal Fluminense University , Rio de Janeiro , Brazil.
authors.forename: Thaís Nascimento
authors.initials: TN
authors.lastname: Magalhães
authors.affiliation: a Neurology Department , Federal Fluminense University , Rio de Janeiro , Brazil.
authors.forename: Taís Pais Resende
authors.initials: TP
authors.lastname: Benevides
authors.affiliation: a Neurology Department , Federal Fluminense University , Rio de Janeiro , Brazil.
authors.forename: Arielle
authors.initials: A
authors.lastname: Kirmse
authors.affiliation: a Neurology Department , Federal Fluminense University , Rio de Janeiro , Brazil.
authors.forename: Joao Gabriel
authors.initials: JG
authors.lastname: Dib
authors.affiliation: a Neurology Department , Federal Fluminense University , Rio de Janeiro , Brazil.
authors.forename: Henrique
authors.initials: H
authors.lastname: Cal
authors.affiliation: a Neurology Department , Federal Fluminense University , Rio de Janeiro , Brazil.|b Faculty of Medicine , Severino Sombra University , Vassouras , Brazil.
authors.forename: Marco
authors.initials: M
authors.lastname: Orsini
authors.affiliation: a Neurology Department , Federal Fluminense University , Rio de Janeiro , Brazil.
authors.forename: Lucas Masiêro
authors.initials: LM
authors.lastname: Araujo
mesh_terms: D001284:Atrophy; D006233:Persons with Disabilities; D018450:Disease Progression; D006801:Humans; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000503:physiopathology; D012008:Recurrence
keywords: Multiple sclerosis; NEDA; demyelinating disease; drugs; neuroimmunology