title: Screening for Identification of Personalized Food to Promote Adiponectin Secretion in Patients with Cancer.
abstract: OBJECTIVE
  Adiponectin is secreted specifically from adipose tissue. Low serum adiponectin levels may cause metabolic syndrome, which is also a risk factor for carcinogenesis. Several studies have suggested a negative correlation between adiponectin and risk of cancers. This study examined the adiponectin secretion-promoting effect of food ingredients in adipose-derived stem cells (ADSCs) obtained from patients with cancer.
  
  
  METHODS
  ADSCs from 7 lifestyle disease cancer patients were differentiated into adipocytes. Subsequently, the adipocytes were treated with 49 food constituents. The adiponectin levels in cell culture supernatants were measured after 48 and 96 h.
  
  
  RESULTS
  Soy genistein extract, lychee low-molecular-weight polyphenol, olive extract and turmeric promoted adiponectin secretion.
  
  
  CONCLUSIONS
  Food constituents that promoted adiponectin secretion were identified using ADSCs derived from patients. This study suggested the possibility of a new treatment approach to prevent cancer recurrence.
authors.affiliation: Department of Integrative Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Miki
authors.initials: M
authors.lastname: Sakaue
authors.affiliation: Kitasenri Maeda Clinic, Suita, Japan.
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Maeda
authors.affiliation: Department of Integrative Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ohno
authors.affiliation: Department of Integrative Medicine, Osaka University Graduate School of Medicine, Osaka, Japan juki@cam.med.osaka-u.ac.jp.
authors.forename: Toshinori
authors.initials: T
authors.lastname: Ito
mesh_terms: D052242:Adiponectin / Q000378:metabolism*; D052436:Adipose Tissue, White / Q000473:pathology; D053687:Adult Stem Cells / Q000378:metabolism*; D002478:Cells, Cultured; D003110:Colonic Neoplasms / Q000178:diet therapy; D019587:Dietary Supplements; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D010190:Pancreatic Neoplasms / Q000178:diet therapy; D010936:Plant Extracts / Q000494:pharmacology; D011471:Prostatic Neoplasms / Q000178:diet therapy
chemical_list: D052242:Adiponectin; D010936:Plant Extracts
keywords: Adiponectin; adipose-derived stem cell; cancer; dietary supplements; obesity