title: Selective Metal-Free Deoxygenation of Unsymmetrical 1,2-Dicarbonyl Compounds by Chlorotrimethylsilane and Sodium Iodide.
abstract: For the first time, the combination of chlorotrimethylsilane with NaI is used as a selective reducting system toward 1,2-diketones. This combination is successfully evaluated with several unsymmetrically benzil derivatives, which are reduced in good yields and with a total α-regioselectivity at room temperature. Identification of benzoin intermediates is achieved, and a mechanistic radical process is proposed.
authors.affiliation: BioCIS, Université Paris-Sud, CNRS, équipe labellisée Ligue Contre le Cancer, Université Paris-Saclay , 92290 Châtenay-Malabry, France.
authors.forename: Ling-Zhi
authors.initials: LZ
authors.lastname: Yuan
authors.affiliation: BioCIS, Université Paris-Sud, CNRS, équipe labellisée Ligue Contre le Cancer, Université Paris-Saclay , 92290 Châtenay-Malabry, France.
authors.forename: Dolor
authors.initials: D
authors.lastname: Renko
authors.affiliation: BioCIS, Université Paris-Sud, CNRS, équipe labellisée Ligue Contre le Cancer, Université Paris-Saclay , 92290 Châtenay-Malabry, France.
authors.forename: Ilhem
authors.initials: I
authors.lastname: Khelifi
authors.affiliation: BioCIS, Université Paris-Sud, CNRS, équipe labellisée Ligue Contre le Cancer, Université Paris-Saclay , 92290 Châtenay-Malabry, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Provot
authors.affiliation: BioCIS, Université Paris-Sud, CNRS, équipe labellisée Ligue Contre le Cancer, Université Paris-Saclay , 92290 Châtenay-Malabry, France.
authors.forename: Jean-Daniel
authors.initials: JD
authors.lastname: Brion
authors.affiliation: BioCIS, Université Paris-Sud, CNRS, équipe labellisée Ligue Contre le Cancer, Université Paris-Saclay , 92290 Châtenay-Malabry, France.
authors.forename: Abdallah
authors.initials: A
authors.lastname: Hamze
authors.affiliation: BioCIS, Université Paris-Sud, CNRS, équipe labellisée Ligue Contre le Cancer, Université Paris-Saclay , 92290 Châtenay-Malabry, France.
authors.forename: Mouad
authors.initials: M
authors.lastname: Alami