title: Potential fat-lowering and prebiotic effects of enzymatically treated okara in high-cholesterol-fed Wistar rats.
abstract: This study evaluates the effect of the lipid profile on serum, liver and faeces, and the potential prebiotic effect of diets supplemented with enzymatically treated okara (okara(ET)) in high-cholesterol fed Wistar rats. Triglyceride levels were significantly reduced in the serum (p < 0.01) and liver (p < 0.01) of okara(ET) treated rats. Total lipids, triglycerides and bile acids were significantly higher (p < 0.001) in the faeces of rats fed the okara(ET) diet. The pH of faecal contents from treated okara(ET) rats was lower (p < 0.001), probably due to the significantly higher (p < 0.001) production of short-chain fatty acids (SCFA). Okara(ET), therefore, reduced triglycerides in serum and liver, and increased the excretion of total lipids, triglycerides and bile acids, improving the lipid profile in rats fed with high-cholesterol diets. Okara(ET) fibre can improve intestinal transit by increasing faecal bulk. The decreased pH and increased SCFA production indicated that okara(ET) fibre fermentation occurred, suggesting a potential prebiotic effect.
authors.affiliation: a Departamento Nutrición y Bromatología II, Facultad de Farmacia , Universidad Complutense de Madrid , Madrid , Spain.
authors.forename: María-José
authors.initials: MJ
authors.lastname: Villanueva-Suárez
authors.affiliation: a Departamento Nutrición y Bromatología II, Facultad de Farmacia , Universidad Complutense de Madrid , Madrid , Spain.
authors.forename: María-Luisa
authors.initials: ML
authors.lastname: Pérez-Cózar
authors.affiliation: a Departamento Nutrición y Bromatología II, Facultad de Farmacia , Universidad Complutense de Madrid , Madrid , Spain.
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Mateos-Aparicio
authors.affiliation: a Departamento Nutrición y Bromatología II, Facultad de Farmacia , Universidad Complutense de Madrid , Madrid , Spain.
authors.forename: Araceli
authors.initials: A
authors.lastname: Redondo-Cuenca
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage / Q000009:adverse effects; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D059305:Diet, High-Fat / Q000009:adverse effects*; D005232:Fatty Acids, Volatile / Q000378:metabolism; D005243:Feces / Q000737:chemistry; D005285:Fermentation; D006863:Hydrogen-Ion Concentration; D006937:Hypercholesterolemia / Q000097:blood / Q000628:therapy*; D007413:Intestinal Mucosa / Q000378:metabolism; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D056692:Prebiotics / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D045730:Soy Foods; D014280:Triglycerides / Q000097:blood
chemical_list: D001647:Bile Acids and Salts; D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D005232:Fatty Acids, Volatile; D056692:Prebiotics; D014280:Triglycerides
keywords: Dietary fibre; fermentability; hypocholesterolaemic effect; okara; prebiotic