title: Microparticles as biomarkers of venous thromboembolic events.
abstract: Microparticles (MPs) are small (0.1-1.0 μm) membrane vesicles constitutively released from the surface of cells after activation and apoptosis. The clinical research on MPs is hampered by the limitations of the currently available detection methods. A correlation between MPs and venous thromboembolism (VTE) has been observed. The effects of MPs on thrombogenesis involve the exposure of phosphatidylserine, the vehiculation of tissue factor, and MP-induced intercellular cross-talk between inflammation and coagulation. This review will focus on the potential role of plasma MPs as biomarkers in detecting acute unprovoked VTE, predicting VTE occurrence in high-risk situations (mainly cancer), and ultimately, we will discuss currently available studies on the prognostic role of MPs to guide primary and secondary VTE prevention protocols.
authors.affiliation: Department of Medicine (DIMED), University of Padua, Padua, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Campello
authors.affiliation: Department of Medicine (DIMED), University of Padua, Padua, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Spiezia
authors.affiliation: Department of Medicine (DIMED), University of Padua, Padua, Italy.
authors.forename: Claudia M
authors.initials: CM
authors.lastname: Radu
authors.affiliation: Department of Medicine (DIMED), University of Padua, Padua, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Simioni
mesh_terms: D000208:Acute Disease; D017304:Annexin A5 / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism*; D002450:Cell Communication; D055252:Cell-Derived Microparticles / Q000378:metabolism*; D006801:Humans; D012307:Risk Factors; D054556:Venous Thromboembolism / Q000175:diagnosis* / Q000473:pathology / Q000517:prevention & control
chemical_list: D017304:Annexin A5; D015415:Biomarkers
keywords: annexin; biomarkers; cancer; flow cytometry; microparticles; microvesicles; thrombosis; tissue factor