title: Assessment of Tachykinin Receptor 3' Gene Polymorphism rs3733631 in Rosacea.
abstract: Background. Rosacea is a chronic skin disease, possibly following the neurogenic skin inflammation model. Neurokinin B, involved in the pathogenesis of Parkinson's disease, frequently coexisting with subsequent onset of rosacea, is an endogenous ligand of the tachykinin receptor 3 (TACR3). Methods. 128 rosacea patients and 121 matched controls were genotyped for rs3733631 by PCR-RFLP and analyzed by chi-square test. Results. We observed statistically significant predominance of the C/G or G/G genotype (p = 0.006) and of the G allele (p = 0.004) in the papulopustular (PP) form of rosacea and statistically marginal significance of the C/G or G/G genotype in erythematotelangiectatic (ET) rosacea (p = 0.052). Significantly higher frequency of the C/G or G/G genotype and G allele in PP rosacea (p = 0.021 and p = 0.008, resp.) was ascertained within male patients. Conclusion. TACR3 rs3733631 G allele possibly predisposes the evolution of the initial phase of rosacea to the PP and not the ET form in male patients.
authors.affiliation: Department of Dermatology, Faculty of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
authors.forename: Anthony
authors.initials: A
authors.lastname: Karpouzis
authors.affiliation: Department of Medical Biology, Faculty of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
authors.forename: Paschalis
authors.initials: P
authors.lastname: Avgeridis
authors.affiliation: Department of Medical Statistics, Faculty of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
authors.forename: Gregory
authors.initials: G
authors.lastname: Tripsianis
authors.affiliation: Department of Medical Biology, Faculty of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
authors.forename: Elisavet
authors.identifier: 0000-0002-6968-5920
authors.initials: E
authors.lastname: Gatzidou
authors.affiliation: Department of Medical Biology, Faculty of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
authors.forename: Niki
authors.initials: N
authors.lastname: Kourmouli
authors.affiliation: Department of Medical Biology, Faculty of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
authors.forename: Stavroula
authors.identifier: 0000-0002-5723-5973
authors.initials: S
authors.lastname: Veletza