title: Can We Rely on Predicted Basal Metabolic Rate in Patients With Intestinal Failure on Home Parenteral Nutrition?
abstract: Intestinal failure (IF) is a serious and common complication of short bowel syndrome with patients depending on parenteral nutrition (PN) support. Effective nutrition management requires an accurate estimation of the patient's basal metabolic rate (BMR) to avoid underfeeding or overfeeding. However, indirect calorimetry, considered the gold standard for BMR assessment, is a time- and resource-consuming procedure. Consequently, several equations for prediction of BMR have been developed in different settings, but their accuracy in patients with IF are yet to be investigated. We evaluated the accuracy of predicted BMR in clinically stable patients with IF dependent on home parenteral nutrition (HPN).
  
  
  
  In total, 103 patients with IF were included. We used indirect calorimetry for assessment of BMR and calculated predicted BMR using different equations based on anthropometric and/or bioelectrical impedance parameters. The accuracy of predicted BMR was evaluated using Bland-Altman analysis with measured BMR as the gold standard.
  
  
  
  The average measured BMR was 1272 ± 245 kcal/d. The most accurate estimations of BMR were obtained using the Harris-Benedict equation (mean bias, 14 kcal/d [ P = .28]; limits of agreement [LoA], -238 to 266 kcal/d) and the Johnstone equation (mean bias, -16 kcal/d [ P = .24]; LoA, -285 to 253 kcal/d). For both equations, 67% of patients had a predicted BMR from 90%-110% All other equations demonstrated a statistically and clinically significant difference between measured and predicted BMR.
  
  
  
  The Harris-Benedict and Johnstone equations reliably predict BMR in two-thirds of clinically stable patients with IF on HPN.
authors.affiliation: 1 Centre for Nutrition and Bowel Disease, Department of Gastroenterology, Aalborg University Hospital, and Clinical Institute, Aalborg University, Aalborg, Denmark.
authors.forename: Anders
authors.initials: A
authors.lastname: Skallerup
authors.affiliation: 1 Centre for Nutrition and Bowel Disease, Department of Gastroenterology, Aalborg University Hospital, and Clinical Institute, Aalborg University, Aalborg, Denmark.
authors.forename: Louis
authors.initials: L
authors.lastname: Nygaard
authors.affiliation: 1 Centre for Nutrition and Bowel Disease, Department of Gastroenterology, Aalborg University Hospital, and Clinical Institute, Aalborg University, Aalborg, Denmark.|2 Mech-Sense, Department of Gastroenterology & Hepatology, Aalborg University Hospital, Aalborg, Denmark.
authors.forename: Søren Schou
authors.initials: SS
authors.lastname: Olesen
authors.affiliation: 1 Centre for Nutrition and Bowel Disease, Department of Gastroenterology, Aalborg University Hospital, and Clinical Institute, Aalborg University, Aalborg, Denmark.
authors.forename: Lars
authors.initials: L
authors.lastname: Vinter-Jensen
authors.affiliation: 1 Centre for Nutrition and Bowel Disease, Department of Gastroenterology, Aalborg University Hospital, and Clinical Institute, Aalborg University, Aalborg, Denmark.
authors.forename: Marianne
authors.initials: M
authors.lastname: Køhler
authors.affiliation: 1 Centre for Nutrition and Bowel Disease, Department of Gastroenterology, Aalborg University Hospital, and Clinical Institute, Aalborg University, Aalborg, Denmark.
authors.forename: Henrik Højgaard
authors.initials: HH
authors.lastname: Rasmussen
mesh_terms: D000328:Adult; D000368:Aged; D000886:Anthropometry; D001481:Basal Metabolism; D001823:Body Composition; D002153:Calorimetry, Indirect; D017097:Electric Impedance; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D007422:Intestines / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D009751:Nutritional Requirements; D016331:Parenteral Nutrition, Home; D015203:Reproducibility of Results; D012146:Rest; D012778:Short Bowel Syndrome / Q000628:therapy*
keywords: basal metabolic rate; bioelectrical impedance analysis; indirect calorimetry; intestinal failure; parenteral nutrition; predictive equations