title: Islet autotransplantation in a patient with hypercoagulable disorder.
abstract: Total pancreatectomy and islet auto transplantation is a good option for chronic pancreatitis patients who suffer from significant pain, poor quality of life, and the potential of type 3C diabetes and pancreatic cancer. Portal vein thrombosis is the most feared complication of the surgery and chances are increased if the patient has a hypercoagulable disorder. We present a challenging case of islet auto transplantation from our institution. A 29-year-old woman with plasminogen activator inhibitor-4G/4G variant and a clinical history of venous thrombosis was successfully managed with a precise peri- and post-operative anticoagulation protocol. In this paper we discuss the anti-coagulation protocol for safely and successfully caring out islet transplantation and associated risks and benefits.
authors.affiliation: Chirag S Desai, Khalid M Khan, Wanxing Cui, Medstar Georgetown Transplant Institute, Washington, DC 20007, United States.
authors.forename: Chirag S
authors.initials: CS
authors.lastname: Desai
authors.affiliation: Chirag S Desai, Khalid M Khan, Wanxing Cui, Medstar Georgetown Transplant Institute, Washington, DC 20007, United States.
authors.forename: Khalid M
authors.initials: KM
authors.lastname: Khan
authors.affiliation: Chirag S Desai, Khalid M Khan, Wanxing Cui, Medstar Georgetown Transplant Institute, Washington, DC 20007, United States.
authors.forename: Wanxing
authors.initials: W
authors.lastname: Cui
keywords: Autoislet transplant; Chronic pancreatitis; Heparin; Hypercoagulable disorder; Islet transplantation; Pancreatectomy