title: Pseudoxylallemycins A-F, Cyclic Tetrapeptides with Rare Allenyl Modifications Isolated from Pseudoxylaria sp. X802: A Competitor of Fungus-Growing Termite Cultivars.
abstract: Based on fungus-fungus pairing assays and HRMS-based dereplication strategy, six new cyclic tetrapeptides, pseudoxylallemycins A-F (1-6), were isolated from the termite-associated fungus Pseudoxylaria sp. X802. Structures were characterized using NMR spectroscopy, HRMS, and Marfey's reaction. Pseudoxylallemycins B-D (2-4) possess a rare and chemically accessible allene moiety amenable for synthetic modifications, and derivatives A-D showed antimicrobial activity against Gram-negative human-pathogenic Pseudomonas aeruginosa and antiproliferative activity against human umbilical vein endothelial cells and K-562 cell lines.
authors.affiliation: Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute , Beutenbergstraße 11a, 07745 Jena, Germany.
authors.forename: Huijuan
authors.initials: H
authors.lastname: Guo
authors.affiliation: Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute , Beutenbergstraße 11a, 07745 Jena, Germany.
authors.forename: Nina B
authors.initials: NB
authors.lastname: Kreuzenbeck
authors.affiliation: Department of Biology, Section for Ecology and Evolution, Centre for Social Evolution, University of Copenhagen , 2100 Copenhagen East, Denmark.
authors.forename: Saria
authors.initials: S
authors.lastname: Otani
authors.affiliation: Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute , Beutenbergstraße 11a, 07745 Jena, Germany.
authors.forename: Maria
authors.initials: M
authors.lastname: Garcia-Altares
authors.affiliation: Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute , Beutenbergstraße 11a, 07745 Jena, Germany.
authors.forename: Hans-Martin
authors.initials: HM
authors.lastname: Dahse
authors.affiliation: Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute , Beutenbergstraße 11a, 07745 Jena, Germany.
authors.forename: Christiane
authors.initials: C
authors.lastname: Weigel
authors.affiliation: Laboratory of Genetics, Wageningen University , P.O. Box 309, 6700 AH Wageningen, The Netherlands.
authors.forename: Duur K
authors.initials: DK
authors.lastname: Aanen
authors.affiliation: Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute , Beutenbergstraße 11a, 07745 Jena, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Hertweck
authors.affiliation: Department of Biology, Section for Ecology and Evolution, Centre for Social Evolution, University of Copenhagen , 2100 Copenhagen East, Denmark.
authors.forename: Michael
authors.initials: M
authors.lastname: Poulsen
authors.affiliation: Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute , Beutenbergstraße 11a, 07745 Jena, Germany.
authors.forename: Christine
authors.initials: C
authors.lastname: Beemelmanns
mesh_terms: D000466:Alkadienes / Q000737:chemistry; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D000898:Antibiosis; D001203:Ascomycota / Q000737:chemistry; D049109:Cell Proliferation; D061307:Human Umbilical Vein Endothelial Cells / Q000187:drug effects / Q000502:physiology; D006801:Humans; D020128:Inhibitory Concentration 50; D020049:Isoptera; D020014:K562 Cells; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000466:Alkadienes; D000900:Anti-Bacterial Agents; D010456:Peptides, Cyclic; C025947:propadiene