title: Enantioselective Synthesis of Guaianolides in the Osmitopsin Family by Domino Metathesis.
abstract: Relay metathesis enabled an improved access from (S)-citronellal to the marine trisnorguaiane (-)-clavukerin A. This hydroazulene was applied as an advantageously functionalized building block for the asymmetric synthesis of the sesquiterpene lactone osmitopsin and the proposed structure of 4,5-epoxyosmitopsin using a chemo-, regio-, and diastereoselective diepoxide opening as the key step.
authors.affiliation: Fachrichtung Chemie und Lebensmittelchemie, Organische Chemie I, Technische Universität Dresden , Bergstrasse 66, 01069 Dresden, Germany.
authors.forename: André
authors.initials: A
authors.lastname: Barthel
authors.affiliation: Fachrichtung Chemie und Lebensmittelchemie, Organische Chemie I, Technische Universität Dresden , Bergstrasse 66, 01069 Dresden, Germany.
authors.forename: Felix
authors.initials: F
authors.lastname: Kaden
authors.affiliation: Fachrichtung Chemie und Lebensmittelchemie, Organische Chemie I, Technische Universität Dresden , Bergstrasse 66, 01069 Dresden, Germany.
authors.forename: Anne
authors.initials: A
authors.lastname: Jäger
authors.affiliation: Fachrichtung Chemie und Lebensmittelchemie, Organische Chemie I, Technische Universität Dresden , Bergstrasse 66, 01069 Dresden, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Metz