title: A case of medulloblastoma in adult patient affected by anaplastic oligoastrocytoma.
abstract: Medulloblastomas and high-grade gliomas (HGG) are two distinct brain tumor, with different peculiarities in terms of age of onset, localizations and prognosis. The coexistence of the two neoplasms in the same adult patient is an extremely rare event. We present the case of a woman treated with radio-chemotherapy for an HGG, who developed a cerebellar medulloblastoma 7 years later. Considering the poor prognosis of these tumors, the lack of knowledge about the mechanisms of onset as well as effective therapies, it is necessary to determine the exact role of irradiation and the presence of any potential molecular genetic abnormalities in the developing of the two tumors.
authors.affiliation: Neuro Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Simonetti
authors.affiliation: Neuro Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy. paola.gaviani@istituto-besta.it.
authors.forename: Paola
authors.initials: P
authors.lastname: Gaviani
authors.affiliation: Neuro Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Lamperti
authors.affiliation: Neuro Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Innocenti
authors.affiliation: Neuro Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Botturi
authors.affiliation: Neurosurgery Department, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Saini
authors.affiliation: Neuropathology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Pollo
authors.affiliation: Neuro Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Silvani
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000532:radiotherapy; D002528:Cerebellar Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008527:Medulloblastoma / Q000000981:diagnostic imaging / Q000556:secondary*; D009837:Oligodendroglioma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy
chemical_list: D000970:Antineoplastic Agents
keywords: Genetic abnormalities; High-grade glioma; Medulloblastoma; Radiotherapy-induced tumors