title: Aza-Michael Mono-addition Using Acidic Alumina under Solventless Conditions.
abstract: Aza-Michael reactions between primary aliphatic and aromatic amines and various Michael acceptors have been performed under environmentally-friendly solventless conditions using acidic alumina as a heterogeneous catalyst to selectively obtain the corresponding mono-adducts in high yields. Ethyl acrylate was the main acceptor used, although others such as acrylonitrile, methyl acrylate and acrylamide were also utilized successfully. Bi-functional amines also gave the mono-adducts in good to excellent yields. Such compounds can serve as intermediates for the synthesis of anti-cancer and antibiotic drugs.
authors.affiliation: Department of Chemistry, University of Malta, Msida MSD 2080, Malta. giovanna.bosica@um.edu.mt.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Bosica
authors.affiliation: Department of Chemistry, University of Malta, Msida MSD 2080, Malta. roderick.abdilla.12@um.edu.mt.
authors.forename: Roderick
authors.initials: R
authors.lastname: Abdilla
mesh_terms: D000143:Acids / Q000737:chemistry; D020106:Acrylamide / Q000737:chemistry; D000179:Acrylates / Q000737:chemistry; D000181:Acrylonitrile / Q000737:chemistry; D000537:Aluminum Oxide / Q000737:chemistry* / Q000627:therapeutic use; D000588:Amines / Q000737:chemistry* / Q000627:therapeutic use; D002384:Catalysis; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy; D012997:Solvents
chemical_list: D000143:Acids; D000179:Acrylates; D000588:Amines; D012997:Solvents; D020106:Acrylamide; D000537:Aluminum Oxide; D000181:Acrylonitrile; C035956:methyl acrylate
keywords: Aza-Michael reactions; acidic alumina; mono-addition; primary amines; solvent-free