title: Is dehydration test using isosorbide useful in Meniere's disease?
abstract: CONCLUSIONS
  The dehydration test using isosorbide is well tolerated when used to detect endolymphatic hydrops and may also be used to improve the sensitivity of ECoG performed on patients with MD, especially in poor hearing at low-frequency.
  
  
  OBJECTIVE
  This prospective study was to explore the diagnostic utility of a dehydration test, administering oral isosorbide, which has been used to treat Meniere's disease (MD).
  
  
  METHODS
  Electrocochleography (ECoG) and the dehydration test with isosorbide were performed on 32 patients diagnosed with definite diagnosed MD. Isosorbide (120 mL) was orally administered after baseline audiometric testing, and the testing was repeated 3 h later. The dehydration test was considered positive when improvements in hearing thresholds of 10 dB or more were evident at two or more frequencies, or the speech discrimination score increased by 12% or more. An abnormal ECoG finding was defined as an SP/AP (summating potential/action potential) ratio ≥0.4.
  
  
  RESULTS
  The dehydration test using isosorbide was positive in 10 of 32 patients (31.3%). The test was not associated with development of any serious side-effect. Abnormal ECoG findings were noted in 14 of 32 patients (43.8%). When endolymphatic hydrops was defined as an abnormal ECoG or a positive dehydration test, the condition was detected in 21 of 32 patients (65.6%). The positive result in dehydration test was significantly higher in patients with above moderate hearing loss at low-frequency.
authors.affiliation: a Department of Otorhinolaryngology-Head and Neck Surgery , Soonchunhyang University College of Medicine , Bucheon , Korea.
authors.forename: Jong Dae
authors.initials: JD
authors.lastname: Lee
authors.affiliation: b Department of Otorhinolaryngology-Head and Neck Surgery , Inha University College of Medicine , Incheon , Korea.
authors.forename: Hyun Ji
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: c Department of Otorhinolaryngology , Yonsei University College of Medicine , Seoul , Korea.
authors.forename: Jinsei
authors.initials: J
authors.lastname: Jung
authors.affiliation: c Department of Otorhinolaryngology , Yonsei University College of Medicine , Seoul , Korea.
authors.forename: Sung Huhn
authors.initials: SH
authors.lastname: Kim
authors.affiliation: a Department of Otorhinolaryngology-Head and Neck Surgery , Soonchunhyang University College of Medicine , Bucheon , Korea.
authors.forename: Bo Gyung
authors.initials: BG
authors.lastname: Kim
authors.affiliation: b Department of Otorhinolaryngology-Head and Neck Surgery , Inha University College of Medicine , Incheon , Korea.
authors.forename: Kyu-Sung
authors.initials: KS
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D001300:Audiometry, Evoked Response; D004234:Diuretics, Osmotic / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007547:Isosorbide / Q000627:therapeutic use*; D008297:Male; D008575:Meniere Disease / Q000188:drug therapy*; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D004234:Diuretics, Osmotic; D007547:Isosorbide
keywords: Electrocochleography; Meniere’s disease; isosorbide