title: Relationship between platelet parameters and hepatic pathology in patients with chronic hepatitis B infection - a retrospective cohort study of 677 patients.
abstract: OBJECTIVE
  A retrospective study to determine the relationships between platelet parameters and inflammation and fibrosis of the liver in patients with chronic hepatitis B virus infection (CHB).
  
  
  METHODS
  Patients with liver biopsy-confirmed CHB were included in the study. Liver fibrosis and inflammation were assessed by histopathology of biopsied liver tissue. Platelet count (PLT), platelet distribution width (PDW) and mean platelet volume (MPV) were determined as part of routine blood tests. The relationship between inflammation and fibrosis and platelet parameters were analysed by multiple linear regression.
  
  
  RESULTS
  The study included 677 patients. PLT and PDW accounted for 20.5% of liver inflammation. PLT and PDW accounted for 18.4% of liver fibrosis.
  
  
  CONCLUSIONS
  Platelet parameters can provide valuable information for the assessment of hepatic inflammation and fibrosis.
authors.affiliation: Department of Infectious Diseases, The First Affiliated Hospital of Xiamen University, Xiamen, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Pan
authors.affiliation: Sixth affiliated hospital of Xinjiang Medical University, Xinjiang, China akrammuharram@163.com.
authors.forename: Aikeremujiang
authors.initials: A
authors.lastname: Muheremu
authors.affiliation: Department of Infectious Diseases, The First Affiliated Hospital of Xiamen University, Xiamen, China.
authors.forename: Xiaolu
authors.initials: X
authors.lastname: Wu
authors.affiliation: Department of Infectious Diseases, The First Affiliated Hospital of Xiamen University, Xiamen, China.
authors.forename: Jiajun
authors.initials: J
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People; D001792:Blood Platelets / Q000473:pathology*; D002648:Child; D005260:Female; D019694:Hepatitis B, Chronic / Q000473:pathology*; D006801:Humans; D007249:Inflammation / Q000473:pathology; D008099:Liver / Q000473:pathology*; D008103:Liver Cirrhosis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012189:Retrospective Studies
keywords: Hepatitis B; chronic hepatitis; correlation; histology; platelet