title: How can we address the controversies surrounding the use of NSAIDS in neurodegeneration?
authors.affiliation: The Center for Experimental Therapeutics & Pharmacoinformatics, Department of Pharmacological & Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204, USA.
authors.forename: Qing-Lan
authors.initials: QL
authors.lastname: Ling
authors.affiliation: The Center for Experimental Therapeutics & Pharmacoinformatics, Department of Pharmacological & Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204, USA.
authors.forename: Emma
authors.initials: E
authors.lastname: Murdoch
authors.affiliation: The Center for Experimental Therapeutics & Pharmacoinformatics, Department of Pharmacological & Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204, USA.
authors.forename: Ke-He
authors.initials: KH
authors.lastname: Ruan
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D016718:Arachidonic Acid / Q000378:metabolism; D051545:Cyclooxygenase 1 / Q000737:chemistry / Q000378:metabolism; D051546:Cyclooxygenase 2 / Q000737:chemistry / Q000378:metabolism; D015232:Dinoprostone / Q000378:metabolism; D011464:Epoprostenol / Q000378:metabolism; D006801:Humans; D019636:Neurodegenerative Diseases / Q000188:drug therapy*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016718:Arachidonic Acid; D011464:Epoprostenol; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D015232:Dinoprostone
keywords: COX-1-10aa-PGIS; COX-2-10aa-mPGES-1; NSAIDs; PGE2; PGI2; cyclooxygenase; hybrid enzyme; neurodegeneration; neuroinflammation; nonsteroidal anti-inflammatory drugs