title: Antistress Effects of Rosa rugosa Thunb. on Total Sleep Deprivation-Induced Anxiety-Like Behavior and Cognitive Dysfunction in Rat: Possible Mechanism of Action of 5-HT6 Receptor Antagonist.
abstract: Our previous results suggest that the Rosa rugosa Thunb. (family Rosaceae) alleviates endurance exercise-induced stress by decreasing oxidative stress levels. This study aimed to screen and identify the physiological antistress effects of an extract of R. rugosa (RO) on sleep deprivation-induced anxiety-like behavior and cognitive tests (in vivo) and tested for hippocampal CORT and monoamine levels (ex vivo), corticosterone (CORT)-induced injury, N-methyl-d-aspartate (NMDA) receptor, and serotonin 6 (5-hydroxytryptamine 6, 5-HT6) receptor activities (in vitro) in search of active principles and underlying mechanisms of action. We confirmed the antistress effects of RO in a sleep-deprived stress model in rat and explored the underlying mechanisms of its action. In conclusion, an R. rugosa extract showed efficacy and potential for use as an antistress therapy to treat sleep deprivation through its antagonism of the 5-HT6 receptor and resulting inhibition of cAMP activity.
authors.affiliation: 1 Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research (JINR) , Jeollanamdo, Korea.|2 Division of Food and Nutrition, Chonnam National University , Gwangju, Korea.
authors.forename: Ju-Ryun
authors.initials: JR
authors.lastname: Na
authors.affiliation: 1 Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research (JINR) , Jeollanamdo, Korea.
authors.forename: Dool-Ri
authors.initials: DR
authors.lastname: Oh
authors.affiliation: 1 Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research (JINR) , Jeollanamdo, Korea.
authors.forename: SeulHee
authors.initials: S
authors.lastname: Han
authors.affiliation: 1 Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research (JINR) , Jeollanamdo, Korea.
authors.forename: Yu-Jin
authors.initials: YJ
authors.lastname: Kim
authors.affiliation: 1 Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research (JINR) , Jeollanamdo, Korea.
authors.forename: EunJin
authors.initials: E
authors.lastname: Choi
authors.affiliation: 1 Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research (JINR) , Jeollanamdo, Korea.
authors.forename: Donghyuck
authors.initials: D
authors.lastname: Bae
authors.affiliation: 3 Korea INSPharm INC, Jeollanamdo, Korea.
authors.forename: Dong Hwan
authors.initials: DH
authors.lastname: Oh
authors.affiliation: 4 Department of Food Science and Nutrition, The University of Suwon , Kyunggi-do, Korea.
authors.forename: Yoo-Hyun
authors.initials: YH
authors.lastname: Lee
authors.affiliation: 1 Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research (JINR) , Jeollanamdo, Korea.|2 Division of Food and Nutrition, Chonnam National University , Gwangju, Korea.|5 B&Tech Co., Ltd., R&D Center , Gwangju, Korea.
authors.forename: Sunoh
authors.initials: S
authors.lastname: Kim
authors.affiliation: 2 Division of Food and Nutrition, Chonnam National University , Gwangju, Korea.
authors.forename: Woojin
authors.initials: W
authors.lastname: Jun
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D001007:Anxiety / Q000188:drug therapy / Q000378:metabolism*; D001522:Behavior, Animal; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D060825:Cognitive Dysfunction / Q000188:drug therapy / Q000378:metabolism*; D003345:Corticosterone / Q000378:metabolism; D000242:Cyclic AMP / Q000037:antagonists & inhibitors; D004298:Dopamine / Q000378:metabolism; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D011985:Receptors, Serotonin / Q000378:metabolism*; D027826:Rosa; D012701:Serotonin / Q000097:blood; D012890:Sleep / Q000502:physiology; D012892:Sleep Deprivation / Q000150:complications / Q000378:metabolism / Q000523:psychology*; D013312:Stress, Physiological / Q000187:drug effects*
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D016194:Receptors, N-Methyl-D-Aspartate; D011985:Receptors, Serotonin; C097216:serotonin 6 receptor; D012701:Serotonin; D000242:Cyclic AMP; D004298:Dopamine; D003345:Corticosterone
keywords: 5-HT6 receptor; Rosa rugosa; cAMP inhibition; cognition; sleep deprivation; stress