title: 25-Hydroxyvitamin D and Parathyroid Hormone Levels Are Independently Associated with the Hemoglobin A1c Level of Korean Type 2 Diabetic Patients: The Dong-Gu Study.
abstract: In type 2 diabetic patients, the relationships between 25-hydroxyvitamin D and parathyroid hormone levels, and glycemic control, remain unclear. We evaluated associations between 25-hydroxyvitamin D, parathyroid hormone, and hemoglobin A1c levels after adjusting for other covariates, including log transformed 25-hydroxyvitamin D levels and log transformed parathyroid hormone levels, in Korean patients with type 2 diabetes. In total, 1,175 patients with type 2 diabetes were selected from 8,857 individuals who completed the baseline survey of the Dong-gu study, conducted in Korea from 2007 to 2010. After adjusting for other covariates, we found that the mean hemoglobin A1c level was inversely associated with the 25-hydroxyvitamin D level (Q1: 7.47% [7.30-7.63], Q2: 7.25% [7.09-7.40], Q3: 7.17% [7.02-7.32], Q4: 7.19% [7.02-7.35]; p for trend = 0.021, p for between groups = 0.050) and the parathyroid hormone level (Q1: 7.35% [7.19-7.51], Q2: 7.34% [7.19-7.50], Q3: 7.28% [7.13-7.43], Q4: 7.09% [6.94-7.24]; p for trend = 0.022, p for between groups = 0.048). However, the mean fasting glucose level was not associated with either the 25-hydroxyvitamin D or parathyroid hormone level. In conclusion, inverse associations were evident between hemoglobin A1c, 25-hydroxyvitamin D and parathyroid hormone levels in Korean patients with type 2 diabetes. The associations remained significant after adjusting for other covariates, including the log transformed 25-hydroxyvitamin D levels and log transformed parathyroid hormone levels.
authors.affiliation: Department of Preventive Medicine, Chosun University Medical School, 309, Pilmun-daero, Dong-gu, Gwangju 501-759, Republic of Korea.
authors.forename: Seong-Woo
authors.identifier: http://orcid.org/0000-0002-6150-3934
authors.initials: SW
authors.lastname: Choi
authors.affiliation: Department of Preventive Medicine, Chonnam National University Medical School, 160, Baekseo-ro, Dong-gu, Gwangju 501-746, Republic of Korea.|Jeonnam Regional Cancer Center, Chonnam National University Hwasun Hospital, 322, Seoyang-ro, Hwasun, Jeollanamdo 519-809, Republic of Korea.
authors.forename: Sun-Seog
authors.initials: SS
authors.lastname: Kweon
authors.affiliation: Department of Preventive Medicine & Institute of Wonkwang Medical Science, Wonkwang University School of Medicine, 344-2 Shinyong-dong, Iksan, Jeollabukdo 570-711, Republic of Korea.
authors.forename: Young-Hoon
authors.initials: YH
authors.lastname: Lee
authors.affiliation: Department of Preventive Medicine, Chosun University Medical School, 309, Pilmun-daero, Dong-gu, Gwangju 501-759, Republic of Korea.
authors.forename: So-Yeon
authors.initials: SY
authors.lastname: Ryu
authors.affiliation: Department of Preventive Medicine, Chonnam National University Medical School, 160, Baekseo-ro, Dong-gu, Gwangju 501-746, Republic of Korea.
authors.forename: Jin-Su
authors.initials: JS
authors.lastname: Choi
authors.affiliation: Department of Preventive Medicine, Chonnam National University Medical School, 160, Baekseo-ro, Dong-gu, Gwangju 501-746, Republic of Korea.
authors.forename: Jung-Ae
authors.initials: JA
authors.lastname: Rhee
authors.affiliation: Department of Preventive Medicine, Chungnam National University Medical School, Munhwa 1(il)-dong, Jung-gu, Daejeon 301-747, Republic of Korea.
authors.forename: Hae-Sung
authors.initials: HS
authors.lastname: Nam
authors.affiliation: Department of Neurology & Research Institute of Clinical Medicine, Biomedical Institute of Chonbuk National University Hospital, Chonbuk National University, San 2-20, Geumam-dong, Deokjin-gu, Jeonju, Jeollabukdo 561-180, Republic of Korea.
authors.forename: Seul-Ki
authors.initials: SK
authors.lastname: Jeong
authors.affiliation: Department of Preventive Medicine, Seonam University College of Medicine, 439, Chunhyang-ro, Namwon, Jeollabukdo 590-711, Republic of Korea.
authors.forename: Kyeong-Soo
authors.initials: KS
authors.lastname: Park
authors.affiliation: Center for Creative Biomedical Scientists, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 500-757, Republic of Korea.
authors.forename: Hee Nam
authors.initials: HN
authors.lastname: Kim
authors.affiliation: Department of Preventive Medicine, Chonnam National University Medical School, 160, Baekseo-ro, Dong-gu, Gwangju 501-746, Republic of Korea.|Center for Creative Biomedical Scientists, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 500-757, Republic of Korea.
authors.forename: Min-Ho
authors.initials: MH
authors.lastname: Shin
mesh_terms: D000368:Aged; D001786:Blood Glucose; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D006306:Health Surveys; D006801:Humans; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D011446:Prospective Studies; D056910:Republic of Korea; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D010281:Parathyroid Hormone; D014807:Vitamin D; C517652:hemoglobin A1c protein, human; C104450:25-hydroxyvitamin D