title: Adult Mesenchymal Stem Cells and Radiation Injury.
abstract: Recent understanding of the cellular and molecular signaling activations in adult mesenchymal stem cells (MSCs) has provided new insights into their potential clinical applications, particularly for tissue repair and regeneration. This review focuses on these advances, specifically in the context of self-renewal for tissue repair and recovery after radiation injury. Thus far, MSCs have been characterized extensively and shown to be useful in mitigation and therapy for acute radiation syndrome and cognitive dysfunction. Use of MSCs for treating radiation injury alone or in combination with additional trauma is foreseeable.
authors.affiliation: *Scientific Research Department, Armed Forces Radiobiology Research Institute; Department of Radiation Biology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20889-1076.
authors.forename: Juliann G
authors.initials: JG
authors.lastname: Kiang
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000473:pathology* / Q000628:therapy*; D019317:Evidence-Based Medicine; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D051379:Mice; D011832:Radiation Injuries / Q000473:pathology* / Q000628:therapy*; D020127:Recovery of Function; D016896:Treatment Outcome