title: Carnosine and the processes of ageing.
abstract: The causes of ageing are usually regarded as multifactorial; thus effective regulation might be achieved by intervention at multiple sites. It has been suggested that the endogenous dipeptide carnosine, also available as a food supplement, possesses anti-ageing activity and may achieve its reported age-alleviating effects via a number of mechanisms. Carnosine's possible anti-ageing mechanisms are therefore discussed; the evidence suggests that inhibition of the mechanistic target of rapamycin and carbonyl scavenging may be involved.
authors.affiliation: Aston Research Centre for Healthy Ageing (ARCHA), Aston University, Birmingham B4 7ET, UK. Electronic address: alanandjill@lineone.net.
authors.forename: Alan R
authors.initials: AR
authors.lastname: Hipkiss
authors.affiliation: Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Melbourne, Australia.
authors.forename: Estifanos
authors.initials: E
authors.lastname: Baye
authors.affiliation: Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Melbourne, Australia; Diabetes and Vascular Medicine Unit, Monash Health, Melbourne, Australia. Electronic address: barbora.decourten@monash.edu.
authors.forename: Barbora
authors.initials: B
authors.lastname: de Courten
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D002336:Carnosine / Q000378:metabolism*; D019587:Dietary Supplements; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D002336:Carnosine
keywords: Advanced glycation end products; Ageing; Carnosine; Inflammation; Oxidative stress; Signalling pathways