title: A case of drug-induced lupus erythematosus secondary to trimethoprim/sulfamethoxazole presenting with pleural effusions and pericardial tamponade.
abstract: We report a case of drug-induced lupus erythematosus (DILE) secondary to trimethoprim/sulfamethoxazole (TMP/SMX) in a patient with underlying inflammatory bowel disease (IBD). The initial presentation was with febrile pleural and pericardial effusions followed by cardiac tamponade. The patient was treated with a short course of corticosteroids with complete resolution of symptoms. To our knowledge this is the first reported case of TMP/SMX-induced DILE presenting with life-threatening serositis. When confronted with sterile exudative effusions, clinicians should strongly consider non-infectious etiologies.
authors.affiliation: Pulmonary, Critical Care and Sleep Medicine Division, The George Washington University, Washington, DC, USA.
authors.forename: A
authors.initials: A
authors.lastname: Jose
authors.affiliation: Pulmonary, Critical Care and Sleep Medicine Division, The George Washington University, Washington, DC, USA.
authors.forename: A K
authors.initials: AK
authors.lastname: Cramer
authors.affiliation: Pulmonary, Critical Care and Sleep Medicine Division, The George Washington University, Washington, DC, USA.
authors.forename: K
authors.initials: K
authors.lastname: Davar
authors.affiliation: Pulmonary, Critical Care and Sleep Medicine Division, The George Washington University, Washington, DC, USA.
authors.forename: G
authors.initials: G
authors.lastname: Gutierrez
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D002305:Cardiac Tamponade / Q000000981:diagnostic imaging* / Q000209:etiology; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced / Q000150:complications*; D008875:Middle Aged; D010996:Pleural Effusion / Q000000981:diagnostic imaging* / Q000209:etiology; D012700:Serositis / Q000188:drug therapy* / Q000209:etiology; D014057:Tomography, X-Ray Computed; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000305:Adrenal Cortex Hormones; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
keywords: Systemic lupus erythematosus; TMP/SMX; cardiovascular disease; drug-induced lupus erythematosus