title: Gallium and Functionalized-Porphyrins Combine to Form Potential Lysosome-Specific Multimodal Bioprobes.
abstract: A water-soluble bimetallic normal ("cold") and radiochemical ("hot") gallium-porphyrin-ruthenium-bipyridine complex (GaporRu-1) has been synthesized by microwave methodology in short reaction times with good (>85%) yields. (68)GaporRu-1 is demonstrated to be a potential multimodal and functional bioprobe for positron emission tomography (PET), lysosome specific optical imaging, and photodynamic therapy.
authors.affiliation: Department of Chemistry, Hong Kong Baptist University , Kowloon Tong, Kowloon, Hong Kong SAR.
authors.forename: Jie
authors.initials: J
authors.lastname: Pan
authors.affiliation: Department of Chemistry, Imperial College London, South Kensington Campus , London SW7 2AZ, United Kingdom.
authors.forename: Bethany I
authors.initials: BI
authors.lastname: Harriss
authors.affiliation: Department of Chemistry, Hong Kong Baptist University , Kowloon Tong, Kowloon, Hong Kong SAR.
authors.forename: Chi-Fai
authors.initials: CF
authors.lastname: Chan
authors.affiliation: Department of Chemistry, Hong Kong Baptist University , Kowloon Tong, Kowloon, Hong Kong SAR.
authors.forename: Lijun
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University , Hung Hom, Hong Kong SAR.
authors.forename: Tik-Hung
authors.initials: TH
authors.lastname: Tsoi
authors.affiliation: Department of Chemistry, Imperial College London, South Kensington Campus , London SW7 2AZ, United Kingdom.
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Long
authors.affiliation: Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University , Hung Hom, Hong Kong SAR.
authors.forename: Wing-Tak
authors.initials: WT
authors.lastname: Wong
authors.affiliation: Department of Chemistry, Hong Kong Baptist University , Kowloon Tong, Kowloon, Hong Kong SAR.
authors.forename: Wai-Kwok
authors.initials: WK
authors.lastname: Wong
authors.affiliation: Department of Chemistry, Hong Kong Baptist University , Kowloon Tong, Kowloon, Hong Kong SAR.
authors.forename: Ka-Leung
authors.initials: KL
authors.lastname: Wong
mesh_terms: D005708:Gallium / Q000737:chemistry*; D008247:Lysosomes / Q000737:chemistry*; D015335:Molecular Probes / Q000737:chemistry*; D061848:Optical Imaging; D010778:Photochemotherapy; D011166:Porphyrins / Q000737:chemistry*; D049268:Positron-Emission Tomography
chemical_list: D015335:Molecular Probes; D011166:Porphyrins; D005708:Gallium