title: Lack of association between genetic polymorphism of FTO, AKT1 and AKTIP in childhood overweight and obesity.
abstract: OBJECTIVE
  Obesity is a chronic disease caused by both environmental and genetic factors. Epidemiological studies have documented that increased energy intake and sedentary lifestyle, as well as a genetic contribution, are forces behind the obesity epidemic. Knowledge about the interaction between genetic and environmental components can facilitate the choice of the most effective and specific measures for the prevention of obesity. The aim of this study was to assess the association between the FTO, AKT1, and AKTIP genes and childhood obesity and insulin resistance.
  
  
  METHODS
  This was a case-control study in which SNPs in the FTO (rs99396096), AKT1, and AKTIP genes were genotyped in groups of controls and obese/overweight children. The study included 195 obese/overweight children and 153 control subjects.
  
  
  RESULTS
  As expected, the obese/overweight group subjects had higher body mass index, higher fasting glucose, HOMA-IR index, total cholesterol, low-density lipoprotein, and triglycerides. However, no significant differences were observed in genes polymorphisms genotype or allele frequencies.
  
  
  CONCLUSIONS
  The present results suggest that AKT1, FTO, and AKTIP polymorphisms were not associated with obesity/overweight in Brazilians children. Future studies on the genetics of obesity in Brazilian children and their environment interactions are needed.
authors.affiliation: Universidade Federal de Minas Gerais (UFMG), INCT de Medicina Molecular, Belo Horizonte, MG, Brazil.
authors.forename: Patrícia de Araújo
authors.initials: Pde A
authors.lastname: Pereira
authors.affiliation: Universidade Federal de Minas Gerais (UFMG), INCT de Medicina Molecular, Belo Horizonte, MG, Brazil. Electronic address: antonioalvimjr@gmail.com.
authors.forename: António Marcos
authors.initials: AM
authors.lastname: Alvim-Soares
authors.affiliation: Universidade Estadual Paulista (UNESP), São Paulo, SP, Brazil.
authors.forename: Valéria Cristina
authors.initials: VC
authors.lastname: Sandrim
authors.affiliation: Universidade Federal de Juiz de Fora (UFJF), Instituto de Ciências Biológicas, Departamento de Fisiologia, Juiz de Fora, MG, Brazil.
authors.forename: Carla Márcia Moreira
authors.initials: CM
authors.lastname: Lanna
authors.affiliation: Universidade de São Paulo (USP), Faculdade de Medicina de Ribeirão Preto (FMRP), Departamento de Farmacologia, Ribeirão Preto, SP, Brazil.
authors.forename: Débora Cristine
authors.initials: DC
authors.lastname: Souza-Costa
authors.affiliation: Universidade de São Paulo (USP), Faculdade de Medicina de Ribeirão Preto (FMRP), Departamento de Farmacologia, Ribeirão Preto, SP, Brazil.
authors.forename: Vanessa de Almeida
authors.initials: Vde A
authors.lastname: Belo
authors.affiliation: Universidade Federal de Minas Gerais (UFMG), INCT de Medicina Molecular, Belo Horizonte, MG, Brazil.
authors.forename: Jonas Jardim
authors.initials: JJ
authors.lastname: de Paula
authors.affiliation: Universidade de São Paulo (USP), Faculdade de Medicina de Ribeirão Preto (FMRP), Departamento de Farmacologia, Ribeirão Preto, SP, Brazil.
authors.forename: José Eduardo
authors.initials: JE
authors.lastname: Tanus-Santos
authors.affiliation: Universidade Federal de Minas Gerais (UFMG), INCT de Medicina Molecular, Belo Horizonte, MG, Brazil.
authors.forename: Marco Aurélio
authors.initials: MA
authors.lastname: Romano-Silva
authors.affiliation: Universidade Federal de Minas Gerais (UFMG), INCT de Medicina Molecular, Belo Horizonte, MG, Brazil.
authors.forename: Débora Marques de
authors.initials: DM
authors.lastname: Miranda
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D000293:Adolescent; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO / Q000235:genetics*; D051017:Apoptosis Regulatory Proteins / Q000235:genetics*; D001938:Brazil / Q000208:ethnology; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D050177:Overweight / Q000235:genetics*; D063766:Pediatric Obesity / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics*
chemical_list: C486377:AKTIP protein, human; D048868:Adaptor Proteins, Signal Transducing; D051017:Apoptosis Regulatory Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human; D051057:Proto-Oncogene Proteins c-akt
keywords: AKT1; AKTIP; Childhood obesity; Fat mass and obesity associated; Gene; Massa de gordura obesidade associadas; Obesidade infantil; Polimorfismos de nucleotídeo único; Single-nucleotide polymorphisms