title: Association of Genetic Variants at the 4q25 Locus with Atrial Fibrillation in Indian Population.
abstract: BACKGROUND
  Atrial fibrillation (AF) is the most common cardiac arrhythmia in clinical settings known to impair cardiac function. Genome-wide association studies identified SNPs on chromosome 4q25 to be associated with AF. Till date no information is available from India related to the association of these variants with AF.
  
  
  METHODS
  Two hundred and sixty-seven individuals comprising of 170 patients with Coronary Artery Disease (CAD), 41 patients with AF, and 56 healthy controls were genotyped for rs10033464 and rs2200733 at 4q25 locus.
  
  
  RESULTS
  Strong association of rs10033464 with AF was observed on comparison with control groups (OR: 2.59; 95% CI: 1.08-6.21; P: 0.031) and between post-coronary artery bypass grafting (CABG) AF and control with dominant genetic model (OR: 4.73; 95% CI: 1.50-14.89; P: 0.0071). Comparison of post-CABG AF with CAD also indicated association (OR: 2.73; 95% CI: 0.9-7.56; P value: 0.05). In contrast, the rs2200733 C>T variant did not show any association with post-CABG AF, but with lone AF with the 'T' allele being associated with increased risk was seen (OR: 2.80; 95% CI: 1.08-7.24; P value: 0.042).
  
  
  CONCLUSIONS
  In conclusion, the rs10033464 (T) allele is associated with the risk of post-CABG AF and the rs2200733 (T) with lone AF.
authors.affiliation: Research and Development, SRL Ltd, Goregaon (W), Mumbai, India.
authors.forename: Aparna
authors.initials: A
authors.lastname: Bhanushali
authors.affiliation: Research and Development, SRL Ltd, Goregaon (W), Mumbai, India.
authors.forename: Akhil
authors.initials: A
authors.lastname: Nair
authors.affiliation: Asian Heart Institute, Bandra (E), Mumbai, India.
authors.forename: Ganesh
authors.initials: G
authors.lastname: Jagdale
authors.affiliation: Asian Heart Institute, Bandra (E), Mumbai, India.
authors.forename: Tilak
authors.initials: T
authors.lastname: Suvarna
authors.affiliation: Research and Development, SRL Ltd, Goregaon (W), Mumbai, India.
authors.forename: Bibhu R
authors.initials: BR
authors.lastname: Das
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000235:genetics*; D016022:Case-Control Studies; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D006801:Humans; D007194:India; D016015:Logistic Models; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
keywords: 4q25; association study; atrial fibrillation; coronary artery disease; single nucleotide polymorphisms