title: Retrograde pyelonephritis and lumbar spondylitis as a result of Salmonella typhi in a type 2 diabetes patient with neurogenic bladder.
abstract: We present a case of a 62-year-old diabetic woman with acute pyelonephritis and spondylitis caused by Salmonella typhi. She was admitted to Tokyo Medical Dental University Hospital, Tokyo, Japan, because of unconsciousness and was diagnosed with sepsis by retrograde pyelonephritis as a result of Salmonella typhi. Antibiotics treatment was immediately started; however, she subsequently developed lumbar spondylitis, and long-term conservative treatment with antibiotics and a fixing device were required. This is the first report of a diabetic patient who developed retrograde urinary tract infection with Salmonella typhi, followed by sepsis and spondylitis. The infection could be a result of diabetic neuropathy, presenting neurogenic bladder and hydronephrosis. The patient was successfully treated with antibiotics and became asymptomatic with normal inflammatory marker levels, and no clinical sign of recurrence was observed in the kidney and spine at 4 months.
authors.affiliation: Department of Molecular Endocrinology and Metabolism Graduate School of Medical and Dental Sciences Tokyo Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Fukuda
authors.affiliation: Department of Molecular Endocrinology and Metabolism Graduate School of Medical and Dental Sciences Tokyo Japan.
authors.forename: Ryotaro
authors.initials: R
authors.lastname: Bouchi
authors.affiliation: Department of Molecular Endocrinology and Metabolism Graduate School of Medical and Dental Sciences Tokyo Japan.
authors.forename: Isao
authors.initials: I
authors.lastname: Minami
authors.affiliation: Department of Molecular Endocrinology and Metabolism Graduate School of Medical and Dental Sciences Tokyo Japan.
authors.forename: Norihiko
authors.initials: N
authors.lastname: Ohara
authors.affiliation: Department of Molecular Endocrinology and Metabolism Graduate School of Medical and Dental Sciences Tokyo Japan.
authors.forename: Yujiro
authors.initials: Y
authors.lastname: Nakano
authors.affiliation: Department of Molecular Endocrinology and Metabolism Graduate School of Medical and Dental Sciences Tokyo Japan.
authors.forename: Rie
authors.initials: R
authors.lastname: Nishitani
authors.affiliation: Department of Molecular Endocrinology and Metabolism Graduate School of Medical and Dental Sciences Tokyo Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Murakami
authors.affiliation: Department of Molecular Endocrinology and Metabolism Graduate School of Medical and Dental Sciences Tokyo Japan.
authors.forename: Takato
authors.initials: T
authors.lastname: Takeuchi
authors.affiliation: Department of Molecular Endocrinology and Metabolism Graduate School of Medical and Dental Sciences Tokyo Japan.
authors.forename: Momoko
authors.initials: M
authors.lastname: Akihisa
authors.affiliation: Department of Molecular Endocrinology and Metabolism Graduate School of Medical and Dental Sciences Tokyo Japan.
authors.forename: Masamichi
authors.initials: M
authors.lastname: Fujita
authors.affiliation: Department of Molecular Endocrinology and Metabolism Graduate School of Medical and Dental Sciences Tokyo Japan; Center for Medical Welfare and Liaison Services Tokyo Medical and Dental University Tokyo Japan.
authors.forename: Hajime
authors.initials: H
authors.lastname: Izumiyama
authors.affiliation: Department of Molecular Endocrinology and Metabolism Graduate School of Medical and Dental Sciences Tokyo Japan; Department of Preemptive Medicine and Metabolism Graduate School of Medical and Dental Sciences Tokyo Japan.
authors.forename: Koshi
authors.initials: K
authors.lastname: Hashimoto
authors.affiliation: Department of Molecular Endocrinology and Metabolism Graduate School of Medical and Dental Sciences Tokyo Japan.
authors.forename: Takanobu
authors.initials: T
authors.lastname: Yoshimoto
authors.affiliation: Department of Molecular Endocrinology and Metabolism Graduate School of Medical and Dental Sciences Tokyo Japan; Japan Science and Technology Agency CREST Tokyo Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Ogawa
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003928:Diabetic Nephropathies / Q000150:complications; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae; D008875:Middle Aged; D011704:Pyelonephritis / Q000175:diagnosis / Q000209:etiology*; D012485:Salmonella typhi; D013166:Spondylitis / Q000175:diagnosis / Q000209:etiology*; D014435:Typhoid Fever / Q000150:complications*; D001750:Urinary Bladder, Neurogenic / Q000150:complications*
keywords: Diabetic neuropathy; Retrograde pyelonephritis; Salmonella typhi