title: Apparent Epigenetic Meiotic Double-Strand-Break Disparity in Saccharomyces cerevisiae: A Meta-Analysis.
abstract: Previously published, and some unpublished, tetrad data from budding yeast (Saccharomyces cerevisiae) are analyzed for disparity in gene conversion, in which one allele is more often favored than the other (conversion disparity). One such disparity, characteristic of a bias in the frequencies of meiotic double-strand DNA breaks at the hotspot near the His4 locus, is found in diploids that undergo meiosis soon after their formation, but not in diploids that have been cloned and frozen. Altered meiotic DNA breakability associated with altered metabolism-related chromatin states has been previously reported. However, the above observations imply that such differing parental chromatin states can persist through at least one chromosome replication, and probably more, in a common environment. This conclusion may have implications for interpreting changes in allele frequencies in populations.
authors.affiliation: Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403-1229 fstahl@uoregon.edu.
authors.forename: Franklin W
authors.initials: FW
authors.lastname: Stahl
authors.affiliation: Department of Genetics, University of Leicester, LE1 7RH, United Kingdom.
authors.forename: Maryam Binti Mohamed
authors.initials: MB
authors.lastname: Rehan
authors.affiliation: Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403-1229.
authors.forename: Henriette M
authors.initials: HM
authors.lastname: Foss
authors.affiliation: Department of Genetics, University of Leicester, LE1 7RH, United Kingdom.
authors.forename: Rhona H
authors.initials: RH
authors.lastname: Borts
mesh_terms: D000429:Alcohol Oxidoreductases / Q000235:genetics; D000619:Aminohydrolases / Q000235:genetics; D001123:Argininosuccinate Lyase / Q000235:genetics; D053903:DNA Breaks, Double-Stranded; D053843:DNA Mismatch Repair; D004271:DNA, Fungal / Q000235:genetics; D044127:Epigenesis, Genetic; D005785:Gene Conversion; D011755:Pyrophosphatases / Q000235:genetics; D011995:Recombination, Genetic; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics
chemical_list: D004271:DNA, Fungal; D029701:Saccharomyces cerevisiae Proteins; D000429:Alcohol Oxidoreductases; C092116:HIS4 protein, S cerevisiae; D000619:Aminohydrolases; D011755:Pyrophosphatases; C087900:Arg4 protein, S cerevisiae; D001123:Argininosuccinate Lyase
keywords: ARG4; HIS4; double-strand breaks; genetic recombination; mismatch repair