title: Thyroid functional parameters and correlative autoantibodies as prognostic factors for differentiated thyroid cancers.
abstract: To evaluate the effect of preoperative thyroid functional parameters and thyroid autoantibodies on aggressive clinicopathologic features and lymph node metastasis (LNM) of differentiated thyroid cancer patients. Four hundred twenty consecutive patients with initial surgery were enrolled from July 2010 to July 2015. The associations between aggressive clinicopathologic and LNM factors and thyroid functional & autoantibodies parameters were analyzed. Higher levels of TSH, TGAb or TMAb were found in patients with tumor size≥1 cm (all P<0.05), especially when TSH≥2.5 ulU/ml (P=0.03) and TGAb≥1 (P=0.01). Higher levels of TSH and TGAb and lower levels of T3 and T4 were found in patients with capsular invasion (all P<0.05), particularly when TSH≥2.5ulU/ml (P=0.03) and TGAb≥1 (P=0.005). The patients with multifocality had higher TAbs level (TAbs>1). Higher level of TSH was also found in patients with central LNM (P=0.001) and lateral LNM (P=0.002), especially with TSH≥2.5ulU/ml (P=0.003 and P=0.03). TGAb level was also found higher in patients with central LNM (P=0.02) and lateral LNM (P=0.01), especially with TGAb≥1 (P<0.05 and P=0.01). Higher level of TMAb was found in patients with lateral LNM (P<0.05). Moreover, multivariable analysis revealed that only TGAb was an independently predictive factor for primary tumor size≥1cm (P=0.01); and TSH level (P=0.01) and TGAb≥1 (P<0.05) were associated independently with central LNM. Thus, TSH level and TGAb≥1 were significantly independent predictors for central LNM, and might help make the decision of central neck dissection.
authors.affiliation: Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Head and Neck surgery, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing, China.
authors.forename: Wenbin
authors.initials: W
authors.lastname: Yu
authors.affiliation: Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu, China.
authors.forename: Jinchuan
authors.initials: J
authors.lastname: Fan
authors.affiliation: Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.|Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Guojun
authors.initials: G
authors.lastname: Li
authors.affiliation: Department of Radiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Tao
authors.affiliation: Department of Otorhinolaryngology Head & Neck Surgery, China-Japan Friendship Hospital, Beijing, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Feng
authors.affiliation: Department of Head and Neck Surgery, Sichuan Cancer Hospital, Chengdu, China.
authors.forename: Ronghao
authors.initials: R
authors.lastname: Sun
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D002648:Child; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D012307:Risk Factors; D013954:Thyroglobulin / Q000097:blood; D013961:Thyroid Gland / Q000502:physiology*; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000276:immunology*; D013972:Thyrotropin / Q000097:blood; D055815:Young Adult
chemical_list: D001323:Autoantibodies; C056626:thyroid microsomal antibodies; D013972:Thyrotropin; D013954:Thyroglobulin
keywords: differentiated thyroid carcinoma; prognostic factors; thyroid correlative autoantibodies; thyroid functional parameters