title: Study on Yang-Xu Using Body Constitution Questionnaire and Blood Variables in Healthy Volunteers.
abstract: Traditional Chinese medicine (TCM) formulates treatment according to body constitution (BC) differentiation. Different constitutions have specific metabolic characteristics and different susceptibility to certain diseases. This study aimed to assess the Yang-Xu constitution using a body constitution questionnaire (BCQ) and clinical blood variables. A BCQ was employed to assess the clinical manifestation of Yang-Xu. The logistic regression model was conducted to explore the relationship between BC scores and biomarkers. Leave-one-out cross-validation (LOOCV) and K-fold cross-validation were performed to evaluate the accuracy of a predictive model in practice. Decision trees (DTs) were conducted to determine the possible relationships between blood biomarkers and BC scores. According to the BCQ analysis, 49% participants without any BC were classified as healthy subjects. Among them, 130 samples were selected for further analysis and divided into two groups. One group comprised healthy subjects without any BC (68%), while subjects of the other group, named as the sub-healthy group, had three BCs (32%). Six biomarkers, CRE, TSH, HB, MONO, RBC, and LH, were found to have the greatest impact on BCQ outcomes in Yang-Xu subjects. This study indicated significant biochemical differences in Yang-Xu subjects, which may provide a connection between blood variables and the Yang-Xu BC.
authors.affiliation: National Research Institute of Chinese Medicine, Taipei 112, Taiwan.
authors.forename: Hong-Jhang
authors.initials: HJ
authors.lastname: Chen
authors.affiliation: Taipei Veterans General Hospital, Center for Traditional Medicine, Taipei 112, Taiwan.
authors.forename: Yii-Jeng
authors.initials: YJ
authors.lastname: Lin
authors.affiliation: Biostatistics Center, Taipei Medical University, Taipei 110, Taiwan.
authors.forename: Pei-Chen
authors.initials: PC
authors.lastname: Wu
authors.affiliation: Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan.
authors.forename: Wei-Hsiang
authors.initials: WH
authors.lastname: Hsu
authors.affiliation: National Research Institute of Chinese Medicine, Taipei 112, Taiwan.
authors.forename: Wan-Chung
authors.initials: WC
authors.lastname: Hu
authors.affiliation: Department of Nursing, Hung Kuang University, Taichung 433, Taiwan.
authors.forename: Trong-Neng
authors.initials: TN
authors.lastname: Wu
authors.affiliation: Taipei Veterans General Hospital, Center for Traditional Medicine, Taipei 112, Taiwan; Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei 112, Taiwan.
authors.forename: Fang-Pey
authors.initials: FP
authors.lastname: Chen
authors.affiliation: Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan; School of Pharmacy, National Taiwan University, Taipei 100, Taiwan.
authors.forename: Yun-Lian
authors.initials: YL
authors.lastname: Lin