title: Single nucleotide polymorphisms of MIR-149 gene rs2292832 contributes to the risk of hepatocellular carcinoma, but not overall cancer: a meta-analysis.
abstract: BACKGROUND
  Single nucleotide polymorphism in miRNAs can alter its expression, thus can lead to the development of cancers. Numerous studies have explored the association between MIR-149 gene rs2292832 polymorphism and hepatocellular carcinoma (HCC) risk, but the results remains inconsistent. So, we performed this pooled analyses in order to get a precise result.
  
  
  METHODS
  Odds ratios (OR) with 95% conﬁdence intervals (CI), calculated by STATA software, was used to determine whether MIR-149 gene rs2292832 polymorphism contributes to the risk of HCC. A comprehensive literature search was conducted on Medline (mainly PubMed), Cochrane Library database, Web of science and the China National Knowledge Internet (CNKI) up to March 22, 2016.
  
  
  RESULTS
  A total of 19 studies including 8201 cases and 9294 controls were included in this meta-analysis. Four of 20 studies related to the HCC risk. When all the eligible studies were pooled into this meta-analysis, a signiﬁcant association between MIR-149 gene rs2292832 polymorphism and hepatocellular carcinoma risk was found, while no association was found between this gene polymorphism and overall cancer risk.
  
  
  CONCLUSIONS
  Our meta-analysis supports that the MIR-149 gene rs2292832 polymorphism contributed to the risk of HCC from currently available evidence. However, a study with a larger sample size is needed to further evaluate gene-environment interaction on MIR-149 gene rs2292832 polymorphism and HCC risk.
authors.affiliation: Department of Radiotherapy, Linyi Peoples' Hospital, Linyi, China - qingzhan_liu@126.com.
authors.forename: Hongjun
authors.initials: H
authors.lastname: Jia
authors.forename: Hengwang
authors.initials: H
authors.lastname: Yu
authors.forename: Qingzhan
authors.initials: Q
authors.lastname: Liu
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000453:epidemiology* / Q000235:genetics*; D006801:Humans; D008113:Liver Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000453:epidemiology / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C551557:MIRN149 microRNA, human; D035683:MicroRNAs