title: A modern era comparison of right versus left sided congenital diaphragmatic hernia outcomes.
abstract: OBJECTIVE
  This study aims to retrospectively review outcomes, including neurodevelopmental outcomes, of neonatal right sided congenital diaphragmatic hernias (RCDH) compared with left sided congenital diaphragmatic hernias (L-CDH) treated surgically at our institute.
  
  
  METHODS
  A retrospective review was undertaken of all cases of congenital diaphragmatic hernia (CDH) treated at Princess Margaret Hospital for Children (PMH), Perth, born between 1st January 2002 and 1st August 2012. The outcomes of R-CDH cases were compared with L-CDH cases. We examined duration of ventilatory support, use of patch versus primary closure, the CDH recurrence rates, the number of reoperations and neurodevelopmental follow-up at one year of age.
  
  
  RESULTS
  Forty-nine cases of CDH were operated on at PMH during the 10-year period. Of these, ten cases were R-CDH with 39 L-CDH cases. Of 49 cases, 34 were diagnosed antenatally, 5 R-CDH versus 29 L-CDH. Only 8/39 cases of L-CDH required patch repair for larger defects, while 5/10 R-CDH required patch repair. Postoperative mortality was 6/49 (1/10 right sided versus 5/39 left sided). Recurrence was observed in 5/10 R-CDH versus 6/39 L-CDH with p=0.03. Thirty-three of 43 surviving patients received one-year follow-up with Griffiths general quotient (GQ) assessment demonstrating a median score of 98 for L-CDH (IQR 86 to 104.25) and 91 for R-CDH (IQR 76.5 to 93).
  
  
  CONCLUSIONS
  R-CDH required patch repair more commonly than L-CDH because of larger defect size or complete agenesis. The rate of recurrent herniation was the only morbidity significantly higher in the R-CDH group. Survivors of R-CDH did not have a significant difference in neurodevelopmental outcome compared to L-CDH cases, with both groups exhibiting normal median GQ scores at one year of age.
authors.affiliation: Department of Surgery, Princess Margaret Hospital for Children, Subiaco, Australia. Electronic address: mcollin@me.com.
authors.forename: Michael
authors.initials: M
authors.lastname: Collin
authors.affiliation: Department of Surgery, Princess Margaret Hospital for Children, Subiaco, Australia.
authors.forename: Sarah
authors.initials: S
authors.lastname: Trinder
authors.affiliation: Department of Neonatal Paediatrics, King Edward Memorial Hospital for Women and Princess Margaret Hospital for Children, Subiaco, Australia.
authors.forename: Corrado
authors.initials: C
authors.lastname: Minutillo
authors.affiliation: Department of Neonatal Paediatrics, King Edward Memorial Hospital for Women and Princess Margaret Hospital for Children, Subiaco, Australia.
authors.forename: Shripada
authors.initials: S
authors.lastname: Rao
authors.affiliation: School of Women's and Infants' Health, Faculty of Medicine, Dentistry and Health Sciences, University of Western Australia, Perth, Australia; King Edward Memorial Hospital for Women, Perth, Australia.
authors.forename: Jan
authors.initials: J
authors.lastname: Dickinson
authors.affiliation: Department of Surgery, Princess Margaret Hospital for Children, Subiaco, Australia; School of Surgery, Faculty of Medicine, Dentistry and Health Sciences, University of Western Australia, Perth, Australia.
authors.forename: Naeem
authors.initials: N
authors.lastname: Samnakay
mesh_terms: D002658:Developmental Disabilities / Q000175:diagnosis / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D065630:Hernias, Diaphragmatic, Congenital / Q000150:complications / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D059685:Herniorrhaphy / Q000379:methods; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011183:Postoperative Complications / Q000175:diagnosis; D012008:Recurrence; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: Congenital diaphragmatic hernia; Left-sided; Neurodevelopmental; Outcomes; Right-sided