title: Colitis as the Sole Initial Presentation of Chronic Granulomatous Disease: Histopathologic Clues to Diagnosis.
abstract: Chronic granulomatous disease is a rare, inherited immunodeficiency disorder that reduces the superoxide generation ability of phagocytes, leading to recurrent infections and granulomatous inflammation. We report the case of a previously healthy 3-year-old boy who presented with classic features of Crohn disease. Suspicion from histopathologiclogic assessment allowed early diagnosis and treatment for chronic granulomatous disease before the onset of infections.
authors.affiliation: From the *New York University School of Medicine, New York, New York; †Division of Pediatric Infectious Diseases, Department of Pediatrics, ‡Department of Pathology, and §Division of Pediatric Gastroenterology, Department of Pediatrics, New York University School of Medicine, New York, New York.
authors.forename: Brooke E
authors.initials: BE
authors.lastname: Rosenbaum
authors.forename: Rivfka
authors.initials: R
authors.lastname: Shenoy
authors.forename: Sharon
authors.initials: S
authors.lastname: Vuppula
authors.forename: Kristen
authors.initials: K
authors.lastname: Thomas
authors.forename: Libia
authors.initials: L
authors.lastname: Moy
authors.forename: Aditya
authors.initials: A
authors.lastname: Kaul
mesh_terms: D002675:Child, Preschool; D003092:Colitis / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D003106:Colon / Q000473:pathology; D006105:Granulomatous Disease, Chronic / Q000150:complications / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D006651:Histocytochemistry; D006801:Humans; D008297:Male