title: The interplay of microRNAs and post-ischemic glutamate excitotoxicity: an emergent research field in stroke medicine.
abstract: Stroke is the second leading cause of death and the most common cause of adult disabilities among elderlies. It involves a complex series of mechanisms among which, excitotoxicity is of great importance. Also, miRNAs appear to play role in post-stroke excitotoxicity, and changes in their transcriptome occur right after cerebral ischemia. Recent data indicate that specific miRNAs such as miRNA-223, miRNA-181, miRNA-125a, miRNA-125b, miRNA-1000, miRNA-132 and miRNA-124a regulate glutamate neurotransmission and excitotoxicity during stroke. However, limitations such as poor in vivo stability, side effects and inappropriate biodistribution in miRNA-based therapies still exist and should be overcome before clinical application. Thence, investigation of the effect of application of these miRNAs after the onset of ischemia is a pivotal step for manipulating these miRNAs in clinical use. Given this, present review concentrates on miRNAs roles in post-ischemic stroke excitotoxicity.
authors.affiliation: Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, P.O. Box: 5166614756, Tabriz, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Majdi
authors.affiliation: Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, P.O. Box: 5166614756, Tabriz, Iran. javadmahmoudi1992@yahoo.com.
authors.forename: Javad
authors.initials: J
authors.lastname: Mahmoudi
authors.affiliation: Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, P.O. Box: 5166614756, Tabriz, Iran.
authors.forename: Saeed
authors.initials: S
authors.lastname: Sadigh-Eteghad
authors.affiliation: Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, P.O. Box: 5166614756, Tabriz, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Farhoudi
authors.affiliation: Department of Immunology, Tabriz Branch, Islamic Azad University, Tabriz, Iran.
authors.forename: Siamak Sandoghchian
authors.initials: SS
authors.lastname: Shotorbani
mesh_terms: D002545:Brain Ischemia / Q000378:metabolism*; D018698:Glutamic Acid / Q000378:metabolism*; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D020521:Stroke / Q000378:metabolism*
chemical_list: D035683:MicroRNAs; D018698:Glutamic Acid
keywords: AMPA receptors; Glutamate excitotoxicity; Ischemic stroke; MicroRNA; NMDA receptors