title: Total Synthesis of (+)-SCH 351448: Efficiency via Chemoselectivity and Redox-Economy Powered by Metal Catalysis.
abstract: The polyketide natural product (+)-SCH 351448, a macrodiolide ionophore bearing 14 stereogenic centers, is prepared in 14 steps (LLS). In eight prior syntheses, 22-32 steps were required. Multiple chemoselective and redox-economic functional group interconversions collectively contribute to a step-change in efficiency.
authors.affiliation: University of Texas at Austin , Department of Chemistry, Austin, Texas 78712, United States.
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.affiliation: University of Texas at Austin , Department of Chemistry, Austin, Texas 78712, United States.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Krische
mesh_terms: D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry*; D008670:Metals / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D007783:Lactones; D008670:Metals; C451479:SCH 351448