title: The Distinct Biometric Features of High Myopia Compared to Moderate Myopia.
abstract: To evaluate changes in biometric parameters in myopic eyes.
  
  
  
  412 eyes of 412 young myopic patients underwent ophthalmic examinations including assessments of refractive error, axial length (AL), anterior chamber depth (ACD), and central corneal thickness (CCT). By using spectral domain optical coherence tomography (SD-OCT), peripapillary retinal nerve fiber layer (pRNFL) thickness was measured. Subjects were divided into two groups: a moderate-myope group (-6 diopters (D) or more) and a high-myope group (less than -6 D). The relationships among ocular biometric parameters including pRNFL thickness, AL, ACD, and CCT were calculated for each group.
  
  
  
  In the moderate-myopia group, the anterior chamber deepened as AL increased (Pearson's coefficient = 0.346, p < 0.01). However, in the high-myopia group, ACD did not correlate with AL (Pearson's r = 0.065, p = 0.383). Average pRNFL thickness was also more related to SE than AL in highly myopic eyes.
  
  
  
  In highly myopic eyes, ACD did not increase as AL increased. pRNFL thickness was more related to SE than to AL. That might be due to the uneven elongation of anterior and posterior portions of the eyeball and the discrepancy between distance from the cornea to the fovea and distance from the cornea to the bottom of the eyeball as axial eye elongation. Interpretation of ocular biometric parameter in highly myopic eyes should consider these differences.
authors.affiliation: a HanGil Eye Hospital , Incheon , Korea.
authors.forename: Hye Jin
authors.initials: HJ
authors.lastname: Chung
authors.affiliation: b Department of Ophthalmology and Visual Science , Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea , Seoul , Korea.
authors.forename: Chan Kee
authors.initials: CK
authors.lastname: Park
mesh_terms: D000328:Adult; D058452:Axial Length, Eye / Q000000981:diagnostic imaging*; D001699:Biometry; D003315:Cornea / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D009216:Myopia / Q000175:diagnosis* / Q000503:physiopathology; D012029:Refraction, Ocular / Q000502:physiology*; D015203:Reproducibility of Results; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D041623:Tomography, Optical Coherence / Q000379:methods*; D055815:Young Adult
keywords: Anterior chamber depth; CCT; axial length; myopia; peripapillary RNFL thickness