title: The Plasmair Decontamination System Is Protective Against Invasive Aspergillosis in Neutropenic Patients.
abstract: OBJECTIVE Invasive aspergillosis (IA) is a rare but severe infection caused by Aspergillus spp. that often develops in immunocompromised patients. Lethality remains high in this population. Therefore, preventive strategies are of key importance. The impact of a mobile air decontamination system (Plasmair, AirInSpace, Montigny-le-Bretonneux, France) on the incidence of IA in neutropenic patients was evaluated in this study. DESIGN Retrospective cohort study METHODS Patients with chemotherapy-induced neutropenia lasting 7 days or more were included over a 2-year period. Cases of IA were confirmed using the revised European Organization for Research and Treatment of Cancer (EORTC) criteria. We took advantage of a partial installation of Plasmair systems in the hematology intensive care unit during this period to compare patients treated in Plasmair-equipped versus non-equipped rooms. Patients were assigned to Plasmair-equipped or non-equipped rooms depending only on bed availability. Differences in IA incidence in both groups were compared using Fisher's exact test, and a multivariate analysis was performed to take into account potential confounding factors. RESULTS Data from 156 evaluable patients were available. Both groups were homogenous in terms of age, gender, hematological diagnosis, duration of neutropenia, and prophylaxis. A total of 11 cases of probable IA were diagnosed: 10 in patients in non-equipped rooms and only 1 patient in a Plasmair-equipped room. The odds of developing IA were much lower for patients hospitalized in Plasmair-equipped rooms than for patients in non-equipped rooms (P=.02; odds ratio [OR] =0.11; 95% confidence interval [CI], 0.00-0.84). CONCLUSION In this study, Plasmair demonstrated a major impact in reducing the incidence of IA in neutropenic patients with hematologic malignancies. Infect Control Hosp Epidemiol 2016;37:845-851.
authors.affiliation: 1Service de Biologie Médicale,Centre Hospitalier de Versailles,Le Chesnay,France.
authors.forename: Marie-Paule
authors.initials: MP
authors.lastname: Fernandez-Gerlinger
authors.affiliation: 2Service d'informatique médicale,de biostatistique et de Santé Publique,Hôpital européen Georges Pompidou,AP-HP,Paris,France.
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Jannot
authors.affiliation: 5Service d'Hématologie et d'Oncologie,Centre Hospitalier de Versailles,Le Chesnay,France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Rigaudeau
authors.affiliation: 5Service d'Hématologie et d'Oncologie,Centre Hospitalier de Versailles,Le Chesnay,France.
authors.forename: Juliette
authors.initials: J
authors.lastname: Lambert
authors.affiliation: 1Service de Biologie Médicale,Centre Hospitalier de Versailles,Le Chesnay,France.
authors.forename: Odile
authors.initials: O
authors.lastname: Eloy
authors.affiliation: 7Service de Radiologie,Centre Hospitalier de Versailles,Le Chesnay,France.
authors.forename: François
authors.initials: F
authors.lastname: Mignon
authors.affiliation: 5Service d'Hématologie et d'Oncologie,Centre Hospitalier de Versailles,Le Chesnay,France.
authors.forename: Hassan
authors.initials: H
authors.lastname: Farhat
authors.affiliation: 5Service d'Hématologie et d'Oncologie,Centre Hospitalier de Versailles,Le Chesnay,France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Castaigne
authors.affiliation: 8Service de Prévention du Risque Infectieux,Centre Hospitalier de Versailles,Le Chesnay,France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Merrer
authors.affiliation: 5Service d'Hématologie et d'Oncologie,Centre Hospitalier de Versailles,Le Chesnay,France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Rousselot
mesh_terms: D000368:Aged; D000391:Air Microbiology; D003428:Cross Infection / Q000517:prevention & control*; D003666:Decontamination / Q000379:methods*; D005260:Female; D019337:Hematologic Neoplasms / Q000150:complications / Q000382:microbiology; D006801:Humans; D055744:Invasive Pulmonary Aspergillosis / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000150:complications* / Q000382:microbiology; D012189:Retrospective Studies