title: TAPE: A Biodegradable Hemostatic Glue Inspired by a Ubiquitous Compound in Plants for Surgical Application.
abstract: This video describes the simplest protocol for preparing biodegradable surgical glue that has an effective hemostatic ability and greater water-resistant adhesion strength than commercial tissue adhesives. Medical adhesives have attracted great attention as potential alternative tools to sutures and staples due to their convenience in usage with minimal invasiveness. Although there are several protocols for developing tissue adhesives including those commercially available such as fibrin glues and cyanoacrylate-based materials, mostly they require a series of chemical syntheses of organic molecules, or complicated protein-purification methods, in the case of bio-driven materials (i.e., fibrin glue). Also, the development of surgical glues exhibiting high adhesive properties while maintaining biodegradability is still a challenge due to difficulties in achieving good performance in the wet environment of the body. We illustrate a new method to prepare a medical glue, known as TAPE, by the weight-based separation of a water-immiscible supramolecular aggregate formed after a physical mixing of a plant-derived, wet-resistant adhesive molecule, Tannic Acid (TA), and a well-known biopolymer, Poly(Ethylene) glycol (PEG). With our approach, TAPE shows high adhesion strength, which is 2.5-fold more than commercial fibrin glue in the presence of water. Furthermore, TAPE is biodegradable in physiological conditions and can be used as a potent hemostatic glue against tissue bleeding. We expect the widespread use of TAPE in a variety of medical settings and drug delivery applications, such as polymers for muco-adhesion, drug depots, and others.
authors.affiliation: The Graduate School of Nanoscience and Technology, Korea Advanced Institute of Science and Technology (KAIST).
authors.forename: Keumyeon
authors.initials: K
authors.lastname: Kim
authors.affiliation: The Graduate School of Nanoscience and Technology, Korea Advanced Institute of Science and Technology (KAIST); Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST); haeshin@kaist.ac.kr.
authors.forename: Haeshin
authors.initials: H
authors.lastname: Lee
authors.affiliation: Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST); Center for Systems Biology, Massachusetts General Hospital/Harvard Medical School; Hong.Seonki@mgh.harvard.edu.
authors.forename: Seonki
authors.initials: S
authors.lastname: Hong
mesh_terms: D000269:Adhesives; D003487:Cyanoacrylates; D006490:Hemostatics; D014014:Tissue Adhesives
chemical_list: D000269:Adhesives; D003487:Cyanoacrylates; D006490:Hemostatics; D014014:Tissue Adhesives