title: Current and future treatment options for cystic fibrosis lung disease: latest evidence and clinical implications.
abstract: Treatment for cystic fibrosis (CF) has conventionally targeted downstream consequences of the defect such as mucus plugging and infection. More recently, significant advances have been made in treating the root cause of the disease, namely a defective CF transmembrane conductance regulator (CFTR) gene. This review summarizes current pulmonary treatment options and highlights advances in research and development of new therapies.
authors.affiliation: Royal Brompton & Harefield NHS Foundation Trust, Paediatric Respiratory Medicine, London, UK.
authors.forename: Claire
authors.initials: C
authors.lastname: Edmondson
authors.affiliation: Imperial College London, Paediatric Respirology and Experimental Medicine, London SW7 2AZ, UK.
authors.forename: Jane C
authors.initials: JC
authors.lastname: Davies
keywords: CF transmembrane conductance regulator gene; cystic fibrosis; treatment