title: Hypothermia for neonatal hypoxic-ischemic encephalopathy: NICHD Neonatal Research Network contribution to the field.
abstract: In this article, we summarize the NICHD Neonatal Research Network (NRN) trial of whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy in relation to other randomized controlled trials (RCTs) of hypothermia neuroprotection. We describe the NRN secondary studies that have been published in the past 10 years evaluating clinical, genetic, biochemical, and imaging biomarkers of outcome.
authors.affiliation: Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, 3901 Beaubien Blvd, Detroit, MI 48201. Electronic address: sshankar@med.wayne.edu.
authors.forename: Seetha
authors.initials: S
authors.lastname: Shankaran
authors.affiliation: Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, 3901 Beaubien Blvd, Detroit, MI 48201.
authors.forename: Girija
authors.initials: G
authors.lastname: Natarajan
authors.affiliation: Department of Pediatrics, University of Texas Southwestern, Dallas, TX.
authors.forename: Lina
authors.initials: L
authors.lastname: Chalak
authors.affiliation: Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, 3901 Beaubien Blvd, Detroit, MI 48201.
authors.forename: Athina
authors.initials: A
authors.lastname: Pappas
authors.affiliation: Statistics and Epidemiology Unit, RTI International, Research Triangle Park, Durham, NC.
authors.forename: Scott A
authors.initials: SA
authors.lastname: McDonald
authors.affiliation: Department of Pediatrics, Brown University, Providence, RI.
authors.forename: Abbot R
authors.initials: AR
authors.lastname: Laptook
mesh_terms: D002657:Child Development; D002658:Developmental Disabilities / Q000401:mortality / Q000503:physiopathology*; D006801:Humans; D007036:Hypothermia, Induced; D020925:Hypoxia-Ischemia, Brain / Q000401:mortality / Q000503:physiopathology / Q000628:therapy; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D054582:National Institute of Child Health and Human Development (U.S.); D016032:Randomized Controlled Trials as Topic; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome; D014481:United States
keywords: Biomarkers; Hypothermia Neuroprotection; Hypoxic-ischemic encephalopathy; Neonatal