title: Hexokinase Domain Containing 1 (HKDC1) Gene Variants and their Association with Gestational Diabetes Mellitus in a South Indian Population.
abstract: Hexokinase domain containing 1 (HKDC1), a novel human hexokinase gene, is known to affect glucose metabolism and was shown to have a strong association with 2-h plasma glucose in pregnant women in a recent genome wide association study. This study aimed to evaluate the association of these regulatory variants of HKDC1 (rs1076224, rs4746822, rs2394529 and rs9645501) with gestational diabetes mellitus (GDM) in a South Indian population. The regulatory variants of HKDC1 were genotyped in unrelated 500 women with GDM and 510 non-GDM individuals by using the MassARRAY system and by direct DNA sequencing. The minor alleles of the HKDC1 gene regulatory variants, namely rs10762264 and rs4746822, showed a significant association with GDM and these alleles conferred as much as 1.24 and 1.34 times higher risk for GDM, respectively. This is the first study to demonstrate the association of HKDC1 genetic variants with susceptibility to GDM.
authors.affiliation: Madras Diabetes Research Foundation, Chennai, India.
authors.forename: Sekar
authors.initials: S
authors.lastname: Kanthimathi
authors.affiliation: Madras Diabetes Research Foundation, Chennai, India.
authors.forename: Samuel
authors.initials: S
authors.lastname: Liju
authors.affiliation: Madras Diabetes Research Foundation, Chennai, India.
authors.forename: Dhandapani
authors.initials: D
authors.lastname: Laasya
authors.affiliation: Madras Diabetes Research Foundation, Chennai, India.|Dr.Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non Communicable Diseases Prevention & Control, IDF Centre of Education, Chennai, India.
authors.forename: Ranjit Mohan
authors.initials: RM
authors.lastname: Anjana
authors.affiliation: Madras Diabetes Research Foundation, Chennai, India.|Dr.Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non Communicable Diseases Prevention & Control, IDF Centre of Education, Chennai, India.
authors.forename: Viswanathan
authors.initials: V
authors.lastname: Mohan
authors.affiliation: Madras Diabetes Research Foundation, Chennai, India.
authors.forename: Venkatesan
authors.initials: V
authors.lastname: Radha
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006593:Hexokinase / Q000235:genetics*; D006801:Humans; D007194:India; D015810:Linkage Disequilibrium; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D055815:Young Adult
chemical_list: C000619342:HKDC1 protein, human; D006593:Hexokinase
keywords: 2-h plasma glucose; HKDC1; South Indian; gestational diabetes mellitus; glucose homeostasis; hexokinase