title: Reactivity of patients with maintenance hemodialysis to erythropoietin in the treatment of renal anemia.
abstract: To explore the reactivity of patients with renal anemia (MHD) to erythropoietin (EPO) in maintenance hemodialysis (HD), 31 patients were enrolled in this study. According to the level of serum ferritin (SF), they were divided into two groups; one group received treatment using recombinant human erythropoietin (rHuEPO) and the other group was given iron sucrose. Taking terminal EPO dosage, terminal erythropoietin resistance index (ERI) and rate of change of ERI (ΔERII) as target indexes, the influence of SF level on dosage of EPO was evaluated after usage conditions of relevant substances in a 3-month period. The results revealed that differences of dialysis age, albumin (ALB), blood calcium, initial and terminal SF, variable quantity of hemoglobin (Hb), terminal EPO and ERI between two groups had statistical significance. Furthermore, SF level and terminal EPO (r = -0.37, P < 0. 05) as well as SF level and terminal ERI (r = - 0.39, P <0.05) were negatively correlated. Difference of terminal ERI between the two groups had statistical significance. It can therefore be summarized that supplementing an iron agent intravenously to maintain SF level between 500 ng/ml and 1200 ng/ml may improve reactivity of patients with MHD to EPO. In addition, rHuEPO therapy in treating anemia of patients with MHD has the same effect with intravenous drug delivery, less side effects and is easy to administer.
authors.affiliation: Nephrology Division of Zhengzhou TCM Hospital, Zhengzhou, Henan, China.
authors.forename: J P
authors.initials: JP
authors.lastname: Hu
authors.affiliation: Nephrology Division of Zhengzhou TCM Hospital, Zhengzhou, Henan, China.
authors.forename: X
authors.initials: X
authors.lastname: Cheng
authors.affiliation: Nephrology Division of Zhengzhou TCM Hospital, Zhengzhou, Henan, China.
authors.forename: X F
authors.initials: XF
authors.lastname: Xu
authors.affiliation: Nephrology Division of the Affiliated Hospital of Henan Province Chinese Medicine Research Institute, China.
authors.forename: G J
authors.initials: GJ
authors.lastname: Yu
authors.affiliation: Endocrinology Division of Zhengzhou Central Hospital, Zhengzhou, Henan, China.
authors.forename: F
authors.initials: F
authors.lastname: Luo
authors.affiliation: Nephrology Division of Zhengzhou TCM Hospital, Zhengzhou, Henan, China.
authors.forename: G S
authors.initials: GS
authors.lastname: Zhang
authors.affiliation: Science and Education Department of Zhengzhou TCM Hospital, Zhengzhou, Henan, China.
authors.forename: N
authors.initials: N
authors.lastname: Yang
authors.affiliation: Nephrology Division of Zhengzhou TCM Hospital, Zhengzhou, Henan, China.
authors.forename: P
authors.initials: P
authors.lastname: Shen
authors.affiliation: Vice President, Zhengzhou TCM Hospital, Zhengzhou, Henan, China.
authors.forename: X Y
authors.initials: XY
authors.lastname: Yan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000097:blood / Q000188:drug therapy*; D004921:Erythropoietin / Q000627:therapeutic use*; D005260:Female; D005293:Ferritins / Q000097:blood; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications*; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000627:therapeutic use; D006435:Renal Dialysis
chemical_list: D011994:Recombinant Proteins; D004921:Erythropoietin; D005293:Ferritins