title: Genitourinary cancers: molecular determinants for personalized therapies.
abstract: Recent insights and emerging strategies for individualized therapeutic approaches in patients with genitourinary (GU) cancers are based on patient's genomic and cancer's molecular profiles. This depends on the significant advances made in molecular biology technologies, such as next-generation sequencing and whole-exome sequencing. The rise of such novel techniques has grayly increased our knowledge on cancer cell biology and development, thus allowing to identify complex abnormalities at the genomic level. These findings have paved the way toward what is called precision medicine, thus providing healthcare from an individual perspective in patients with GU tumors.
authors.affiliation: Section of Pathological Anatomy, Marche Polytechnic University, School of Medicine, United Hospitals, Ancona - Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Mazzucchelli
authors.affiliation: Section of Pathological Anatomy, Marche Polytechnic University, School of Medicine, United Hospitals, Ancona - Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Gasparrini
authors.affiliation: Section of Urology, Department of Clinical and Specialist Sciences, Marche Polytechnic University, United Hospitals, Ancona - Italy.
authors.forename: Andrea B
authors.initials: AB
authors.lastname: Galosi
authors.affiliation: Division of Oncology, S. Orsola-Malpighi Hospital, Bologna - Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Massari
authors.affiliation: Histopathology and Molecular Diagnostics, University Hospital Careggi, Florence - Italy.
authors.forename: Maria Rosaria
authors.initials: MR
authors.lastname: Raspollini
authors.affiliation: Section of Pathological Anatomy, Marche Polytechnic University, School of Medicine, United Hospitals, Ancona - Italy.
authors.forename: Marina
authors.initials: M
authors.lastname: Scarpelli
authors.affiliation: Department of Surgery, Cordoba University Medical School, Cordoba - Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Lopez-Beltran
authors.affiliation: Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN - USA.
authors.forename: Liang
authors.initials: L
authors.lastname: Cheng
authors.affiliation: Section of Pathological Anatomy, Marche Polytechnic University, School of Medicine, United Hospitals, Ancona - Italy.
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Montironi
mesh_terms: D023281:Genomics; D006801:Humans; D057285:Precision Medicine; D014565:Urogenital Neoplasms / Q000235:genetics*