title: Two new tenvermectins from a genetically engineered strain Streptomyces avermitilis MHJ1011.
abstract: Two new tenvermectins, tenvermectins C (1) and D (2), were isolated from Streptomyces avermitilis MHJ1011. Their structures were determined by extensive spectroscopic analysis and by comparison with a related known compound, tenvermectin A. Compounds 1 and 2 exhibited potent nematocidal and acaricidal activities against Bursaphelenchus xylophilus and Tetranychus cinnabarinus.
authors.affiliation: a Provincial Joint Engineering Laboratory of Biopesticide Preparation , School of Forestry & Biotechnology, Zhejiang Agricultural and Forestry University , Lin'An 311300 , China.
authors.forename: Xu
authors.initials: X
authors.lastname: Wan
authors.affiliation: a Provincial Joint Engineering Laboratory of Biopesticide Preparation , School of Forestry & Biotechnology, Zhejiang Agricultural and Forestry University , Lin'An 311300 , China.
authors.forename: Shao-Yong
authors.initials: SY
authors.lastname: Zhang
authors.affiliation: b Department of New Drug Screening , Zhejiang Hisun Pharmaceutical Co., Ltd. , Taizhou 318000 , China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.affiliation: a Provincial Joint Engineering Laboratory of Biopesticide Preparation , School of Forestry & Biotechnology, Zhejiang Agricultural and Forestry University , Lin'An 311300 , China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhai
authors.affiliation: b Department of New Drug Screening , Zhejiang Hisun Pharmaceutical Co., Ltd. , Taizhou 318000 , China.
authors.forename: Jun
authors.initials: J
authors.lastname: Huang
authors.affiliation: a Provincial Joint Engineering Laboratory of Biopesticide Preparation , School of Forestry & Biotechnology, Zhejiang Agricultural and Forestry University , Lin'An 311300 , China.
authors.forename: An-Liang
authors.initials: AL
authors.lastname: Chen
authors.affiliation: a Provincial Joint Engineering Laboratory of Biopesticide Preparation , School of Forestry & Biotechnology, Zhejiang Agricultural and Forestry University , Lin'An 311300 , China.|b Department of New Drug Screening , Zhejiang Hisun Pharmaceutical Co., Ltd. , Taizhou 318000 , China.
authors.forename: Ji-Dong
authors.initials: JD
authors.lastname: Wang
mesh_terms: D056810:Acaricides / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000969:Antinematodal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005818:Genetic Engineering; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013302:Streptomyces / Q000737:chemistry* / Q000235:genetics; D040102:Tetranychidae / Q000187:drug effects
chemical_list: D056810:Acaricides; D000969:Antinematodal Agents; D018942:Macrolides; C000616979:tenvermectin C; C000616980:tenvermectin D
keywords: Streptomyces avermitilis MHJ1011; Tenvermectins C and D; nematocidal and acaricidal activities; structure elucidation