title: Acredinone C and the Effect of Acredinones on Osteoclastogenic and Osteoblastogenic Activity.
abstract: A new inhibitor, acredinone C (1), of receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation was isolated from the culture broth of the fungus Acremonium sp. (F9A015) along with acredinones A (2) and B (3). The structure of acredinone C (1), which incorporates benzophenone and xanthone moieties, was established by the analyses of combined spectroscopic data including 1D and 2D NMR and MS. All of the acredinones studied efficiently inhibited the RANKL-induced formation of TRAP(+)-MNCs in a dose-dependent manner without any cytotoxicity up to 10 μM. Acredinone A showed dual activity in both osteoclast and osteoblast differentiation in vitro and good efficacy in an animal disease model of bone formation.
authors.forename: Jeong-Tae
authors.initials: JT
authors.lastname: Yeon
authors.forename: Hiyoung
authors.initials: H
authors.lastname: Kim
authors.forename: Kwang-Jin
authors.initials: KJ
authors.lastname: Kim
authors.forename: Jihye
authors.initials: J
authors.lastname: Lee
authors.forename: Dong Hwan
authors.initials: DH
authors.lastname: Won
authors.affiliation: Department of Chemistry and Nano Science, Global Top 5 Program, Ewha Womans University , Seoul 03760, Korea.
authors.forename: Sang-Jip
authors.initials: SJ
authors.lastname: Nam
authors.affiliation: Laboratory of Translational Therapeutics, Pharmacology Research Center, Division of Drug Discovery Research, Korea Research Institute of Chemical Technology , Daejeon 34114, Korea.
authors.forename: Seong Hwan
authors.initials: SH
authors.lastname: Kim
authors.forename: Heonjoong
authors.initials: H
authors.lastname: Kang
authors.forename: Young-Jin
authors.initials: YJ
authors.lastname: Son
mesh_terms: D000164:Acremonium / Q000737:chemistry*; D000818:Animals; D001577:Benzophenones / Q000737:chemistry / Q000494:pharmacology*; D002454:Cell Differentiation; D004195:Disease Models, Animal; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010010:Osteoclasts / Q000187:drug effects; D010012:Osteogenesis / Q000187:drug effects; D053245:RANK Ligand / Q000037:antagonists & inhibitors
chemical_list: D001577:Benzophenones; D053245:RANK Ligand; C505688:TNFSF11 protein, human; C000598720:acredinone A; C000598721:acredinone B; C000618132:acredinone C