title: Circulating periostin level in asthmatic pregnancy.
abstract: Asthma often complicates pregnancy and represents a risk for complications. Periostin is considered as a biomarker of asthma; however, as it also plays a role in normal gestation, pregnancy may influence circulating periostin levels. This is the first study assessing periostin in asthmatic pregnancy.
  
  
  
  Plasma periostin levels were investigated in asthma (asthmatic non-pregnant, ANP; N = 19) and asthmatic pregnancy (AP; N = 14), compared to healthy non-pregnant controls (HNP; N = 12) and healthy pregnant women (HP; N = 17). The relationship between periostin levels and asthma control determinants was also evaluated. The diagnostic efficacy of periostin to detect uncontrolled asthma was analyzed using ROC analysis.
  
  
  
  Plasma periostin levels were similar in the HNP and ANP (55.68 [37.21-67.20] vs. 45.25 [32.67-64.55], p > 0.05), and elevated in the HP (68.81 [57.34-98.84] ng/mL, p = 0.02 vs. HNP) and AP groups (54.02 [44.30-74.94] ng/mL, p = 0.0346 vs. ANP). Periostin levels of the two pregnant groups were similar (p > 0.05). In AP women periostin correlated negatively with FEV1 (r = -0.5516) and positively with Raw (r = 0.5535; both p < 0.05).
  
  
  
  Pregnancy itself increases circulating periostin levels and this elevation is detectable in asthmatic pregnancy as well. Although periostin correlates with lung function in asthmatic pregnancy, periostin as a biomarker has to be handled with caution in pregnant patients due to the influence of pregnancy on its plasma level.
authors.affiliation: a Department of Pulmonology , Semmelweis University , Budapest , Hungary.
authors.forename: István
authors.initials: I
authors.lastname: Ivancsó
authors.affiliation: a Department of Pulmonology , Semmelweis University , Budapest , Hungary.
authors.forename: Anikó
authors.initials: A
authors.lastname: Bohács
authors.affiliation: b Department of Laboratory Medicine , Semmelweis University , Budapest , Hungary.
authors.forename: Balázs
authors.initials: B
authors.lastname: Szalay
authors.affiliation: c 1st Department of Obstetrics and Gynecology , Semmelweis University , Budapest , Hungary.
authors.forename: Gergely
authors.initials: G
authors.lastname: Toldi
authors.affiliation: d Chest Pain Unit, Internistische Klinik Dr. Müller , München , Germany.
authors.forename: Magdolna E
authors.initials: ME
authors.lastname: Szilasi
authors.affiliation: a Department of Pulmonology , Semmelweis University , Budapest , Hungary.
authors.forename: Veronika
authors.initials: V
authors.lastname: Müller
authors.affiliation: a Department of Pulmonology , Semmelweis University , Budapest , Hungary.
authors.forename: György
authors.initials: G
authors.lastname: Losonczy
authors.affiliation: c 1st Department of Obstetrics and Gynecology , Semmelweis University , Budapest , Hungary.
authors.forename: János
authors.initials: J
authors.lastname: Rigó
authors.affiliation: b Department of Laboratory Medicine , Semmelweis University , Budapest , Hungary.|e Research Group of Pediatrics and Nephrology, Hungarian Academy of Sciences , Budapest , Hungary.
authors.forename: Barna
authors.initials: B
authors.lastname: Vásárhelyi
authors.affiliation: a Department of Pulmonology , Semmelweis University , Budapest , Hungary.
authors.forename: Lilla
authors.initials: L
authors.lastname: Tamási
mesh_terms: D000328:Adult; D001249:Asthma / Q000097:blood* / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D015815:Cell Adhesion Molecules / Q000097:blood*; D005260:Female; D006801:Humans; D011247:Pregnancy / Q000097:blood*; D011248:Pregnancy Complications / Q000097:blood* / Q000503:physiopathology; D012123:Pulmonary Ventilation; D012372:ROC Curve; D012016:Reference Values
chemical_list: D015415:Biomarkers; D015815:Cell Adhesion Molecules; C512835:POSTN protein, human
keywords: Asthma; control; periostin; pregnancy