title: Granuloma faciale successfully treated with ingenol mebutate.
abstract: Granuloma faciale (GF) is a rare chronic inflammatory dermatosis of unknown etiology, characterized by leukocitoclastic vasculitis usually occurring on the face. We report a case of 60-years-old man with 3 year history of multiple actinic keratoses (AK) and persistent asymptomatic erythematous papules and plaques located over his left temporal region and the cheek: histopathology was consistent with GF. Herein we describe the successful treatment of the lesion with ingenol mebutate 0.015% gel focusing on the clinical, dermoscopic and histopathological findings of GF both before and after treatment.
authors.affiliation: Department of Clinical and Molecular Sciences, Dermatological Unit and.
authors.forename: I
authors.initials: I
authors.lastname: Bobyr
authors.affiliation: Department of Clinical and Molecular Sciences, Dermatological Unit and.
authors.forename: A
authors.initials: A
authors.lastname: Campanati
authors.affiliation: Department of Clinical and Molecular Sciences, Dermatological Unit and. consalesveronica@gmail.com.
authors.forename: V
authors.initials: V
authors.lastname: Consales
authors.affiliation: Institute of Pathological Anatomy and Histopathology, Polytechnic Marche University, Ancona, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Giangiacomi
authors.affiliation: Department of Clinical and Molecular Sciences, Dermatological Unit and.
authors.forename: F
authors.initials: F
authors.lastname: Diotallevi
authors.affiliation: Department of Clinical and Molecular Sciences, Dermatological Unit and.
authors.forename: A
authors.initials: A
authors.lastname: Offidani
mesh_terms: D000279:Administration, Cutaneous; D001706:Biopsy; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D046169:Dermoscopy; D004224:Diterpenes / Q000008:administration & dosage / Q000627:therapeutic use*; D005148:Facial Dermatoses / Q000175:diagnosis / Q000188:drug therapy*; D005782:Gels; D006099:Granuloma / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D055623:Keratosis, Actinic / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012074:Remission Induction; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: C486592:3-ingenyl angelate; D003879:Dermatologic Agents; D004224:Diterpenes; D005782:Gels
keywords: granuloma faciale; ingenol mebutate; off label treatment