title: Patterns of care and survival outcomes examining radiation therapy for advanced Hodgkin lymphoma.
abstract: The use of radiation therapy (RT) and its impact on survival in advanced Hodgkin lymphoma (HL) is controversial. Data were obtained from the surveillance, epidemiology, and end results (SEER) registries from 1988-2011. There were 9467 adults who met inclusion criteria; 19% received RT. Radiation use declined from 25% in 1988 to 16% in 2011. Five-year overall survival (OS) for stage III and IV patients for the no versus RT cohorts were 79% versus 88% (p < 0.0001) and 73% versus 84% (p < 0.0001), respectively. RT was associated with improved OS (HR = 0.76; 0.68-0.85) on multivariable analysis and in patients diagnosed after 2000. Although there was a decline in utilization of RT from 1988 to 2011, RT was associated with a survival benefit in stage III-IV HL.
authors.affiliation: a Department of Radiation and Cellular Oncology , University of Chicago Medicine , Chicago , IL , USA.
authors.forename: Christina H
authors.initials: CH
authors.lastname: Son
authors.affiliation: b Department of Public Health Sciences , University of Chicago , Chicago , IL , USA.
authors.forename: Brian C H
authors.initials: BC
authors.lastname: Chiu
authors.affiliation: a Department of Radiation and Cellular Oncology , University of Chicago Medicine , Chicago , IL , USA.|c Department of Radiation Oncology , University of Illinois at Chicago , Chicago , IL , USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: Koshy
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006689:Hodgkin Disease / Q000453:epidemiology / Q000401:mortality* / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D017063:Outcome Assessment, Health Care; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data*; D018426:SEER Program; D014481:United States / Q000453:epidemiology
keywords: Hodgkin; SEER; radiotherapy