title: Mechanisms of DNA Repair by Photolyase and Excision Nuclease (Nobel Lecture).
abstract: Ultraviolet light damages DNA by converting two adjacent thymines into a thymine dimer which is potentially mutagenic, carcinogenic, or lethal to the organism. This damage is repaired by photolyase and the nucleotide excision repair system in E. coli by nucleotide excision repair in humans. The work leading to these results is presented by Aziz Sancar in his Nobel Lecture.
authors.affiliation: Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA. Aziz_Sancar@med.unc.edu.
authors.forename: Aziz
authors.initials: A
authors.lastname: Sancar
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism*; D056931:Cryptochromes / Q000378:metabolism; D004260:DNA Repair; D004255:Deoxyribodipyrimidine Photo-Lyase / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D003851:Deoxyribonucleases / Q000378:metabolism*; D004926:Escherichia coli / Q000201:enzymology / Q000378:metabolism; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011740:Pyrimidine Dimers / Q000737:chemistry / Q000378:metabolism; D014466:Ultraviolet Rays
chemical_list: D056931:Cryptochromes; D011740:Pyrimidine Dimers; D003851:Deoxyribonucleases; D000251:Adenosine Triphosphatases; D004255:Deoxyribodipyrimidine Photo-Lyase
keywords: Maxicell method; circadian clock; cryptochrome; nucleotide excision repair; photoreactivation