title: Hydrogenase Enzymes and Their Synthetic Models: The Role of Metal Hydrides.
abstract: Hydrogenase enzymes efficiently process H2 and protons at organometallic FeFe, NiFe, or Fe active sites. Synthetic modeling of the many H2ase states has provided insight into H2ase structure and mechanism, as well as afforded catalysts for the H2 energy vector. Particularly important are hydride-bearing states, with synthetic hydride analogues now known for each hydrogenase class. These hydrides are typically prepared by protonation of low-valent cores. Examples of FeFe and NiFe hydrides derived from H2 have also been prepared. Such chemistry is more developed than mimicry of the redox-inactive monoFe enzyme, although functional models of the latter are now emerging. Advances in physical and theoretical characterization of H2ase enzymes and synthetic models have proven key to the study of hydrides in particular, and will guide modeling efforts toward more robust and active species optimized for practical applications.
authors.affiliation: Center for Multidimensional Carbon Materials, Institute for Basic Science (IBS) , Ulsan 44919, Republic of Korea.|Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST) , Ulsan 44919, Republic of Korea.
authors.forename: David
authors.initials: D
authors.lastname: Schilter
authors.affiliation: Department of Chemistry, Yeshiva University , 500 West 185th Street, New York, New York 10033, United States.
authors.forename: James M
authors.initials: JM
authors.lastname: Camara
authors.affiliation: Department of Chemistry, University of Illinois at Urbana-Champaign , 600 South Mathews Avenue, Urbana, Illinois 61801, United States.
authors.forename: Mioy T
authors.initials: MT
authors.lastname: Huynh
authors.affiliation: Department of Chemistry, University of Illinois at Urbana-Champaign , 600 South Mathews Avenue, Urbana, Illinois 61801, United States.
authors.forename: Sharon
authors.initials: S
authors.lastname: Hammes-Schiffer
authors.affiliation: Department of Chemistry, University of Illinois at Urbana-Champaign , 600 South Mathews Avenue, Urbana, Illinois 61801, United States.
authors.forename: Thomas B
authors.initials: TB
authors.lastname: Rauchfuss
mesh_terms: D056831:Coordination Complexes / Q000737:chemistry*; D018360:Crystallography, X-Ray; D006859:Hydrogen / Q000737:chemistry*; D006864:Hydrogenase / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D018716:Molecular Mimicry
chemical_list: D056831:Coordination Complexes; D006859:Hydrogen; D006864:Hydrogenase