title: Kidney Injury in Liver Disease.
abstract: Acute kidney injury (AKI) occurs frequently in patients with liver disease and increases morbidity and mortality. Hepatorenal syndrome is a common cause of AKI in patients with decompensated cirrhosis and is due to alterations in systemic and renal hemodynamics. Serum creatinine-based estimation of kidney function is a key component of the Model for End-stage Liver Disease score in liver transplant candidates. Continuous renal replacement therapy is used in critically ill patients with liver failure and AKI. Simultaneous liver-kidney transplantation (SLK) may be required in patients with liver failure and prolonged AKI. Identification of appropriate candidates for SLK remains controversial.
authors.affiliation: Division of Nephrology, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA.
authors.forename: Kevin R
authors.initials: KR
authors.lastname: Regner
authors.affiliation: Department of Anesthesiology, Milton S. Hershey Medical Center, Penn State College of Medicine, PO Box 850, H187, Hershey, PA 17033, USA. Electronic address: ksingbartl@hmc.psu.edu.
authors.forename: Kai
authors.initials: K
authors.lastname: Singbartl
mesh_terms: D000138:Acidosis / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D058186:Acute Kidney Injury / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy; D002908:Chronic Disease; D006530:Hepatorenal Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D006801:Humans; D016030:Kidney Transplantation; D008107:Liver Diseases / Q000150:complications* / Q000628:therapy; D017114:Liver Failure, Acute / Q000150:complications; D016031:Liver Transplantation; D017582:Renal Replacement Therapy / Q000379:methods
keywords: Acute kidney injury; Cirrhosis; Hepatorenal syndrome; Liver transplant