title: Resistive Pulse Analysis of Microgel Deformation During Nanopore Translocation.
abstract: Deformation of 570-nm radius poly(N-isopropylacrylamide-co-acrylic acid) microgels passing through individual 375- to 915-nm radius nanopores in glass has been investigated by the resistive-pulse method. Particle translocation through nanopores of dimensions smaller than the microgel yields electrical signatures reflecting the dynamics of microgel deformation. Translocation rates, and event duration and peak shape, are functions of the conductivities of microgel and electrolyte. Our results demonstrate that nanopore resistive-pulse methods provide new fundamental insights into microgel permeation through porous membranes.
authors.affiliation: Department of Chemistry, University of Utah, 315 S 1400 E, Salt Lake City, UT 84112.
authors.forename: Deric A
authors.initials: DA
authors.lastname: Holden
authors.affiliation: Georgia Institute of Technology, School of Chemistry and Biochemistry and Petit Institute for Bioengineering & Bioscience, 901 Atlantic Drive, NW, Atlanta, GA 30332-0400.
authors.forename: Grant
authors.initials: G
authors.lastname: Hendrickson
authors.affiliation: Georgia Institute of Technology, School of Chemistry and Biochemistry and Petit Institute for Bioengineering & Bioscience, 901 Atlantic Drive, NW, Atlanta, GA 30332-0400.
authors.forename: L Andrew
authors.initials: LA
authors.lastname: Lyon
authors.affiliation: Department of Chemistry, University of Utah, 315 S 1400 E, Salt Lake City, UT 84112.
authors.forename: Henry S
authors.initials: HS
authors.lastname: White
keywords: Microgel; nanopore; resistive pulse