title: (1)H, (13)C, and (15)N resonance assignments for the pro-inflammatory cytokine interleukin-36α.
abstract: Interleukin-36α (IL-36α) is a recently characterised member of the interleukin-1 superfamily. It is involved in the pathogenesis of inflammatory arthritis in one third of psoriasis patients. By binding of IL-36α to its receptor IL-36R via the NF-κB pathway other cytokines involved in inflammatory and apoptotic cascade are activated. The efficacy of complex formation is controlled by N-terminal processing. To obtain a more detailed view on the structure function relationship we performed a heteronuclear multidimensional NMR investigation and here report the (1)H, (13)C, and (15)N resonance assignments for the backbone and side chain nuclei of the pro-inflammatory cytokine interleukin-36α.
authors.affiliation: Leibniz Institute on Aging - Fritz Lipmann Institute, Beutenbergstr. 11, 07745, Jena, Germany.
authors.forename: Nishit
authors.initials: N
authors.lastname: Goradia
authors.affiliation: Pharmaceutical Chemistry I, Institute of Pharmacy, University of Bonn, Brühler Str. 7, 53119, Bonn, Germany.
authors.forename: Amelie
authors.initials: A
authors.lastname: Wißbrock
authors.affiliation: Institute of Biochemistry/Biotechnology, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Str. 3, 06120, Halle/Saale, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Wiedemann
authors.affiliation: Institute of Biochemistry/Biotechnology, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Str. 3, 06120, Halle/Saale, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Bordusa
authors.affiliation: Leibniz Institute on Aging - Fritz Lipmann Institute, Beutenbergstr. 11, 07745, Jena, Germany.
authors.forename: Ramadurai
authors.initials: R
authors.lastname: Ramachandran
authors.affiliation: Pharmaceutical Chemistry I, Institute of Pharmacy, University of Bonn, Brühler Str. 7, 53119, Bonn, Germany.
authors.forename: Diana
authors.initials: D
authors.lastname: Imhof
authors.affiliation: Leibniz Institute on Aging - Fritz Lipmann Institute, Beutenbergstr. 11, 07745, Jena, Germany. oliver.ohlenschlaeger@leibniz-fli.de.
authors.forename: Oliver
authors.initials: O
authors.lastname: Ohlenschläger
mesh_terms: D007249:Inflammation / Q000378:metabolism; D007375:Interleukin-1 / Q000737:chemistry* / Q000378:metabolism*; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D007375:Interleukin-1
keywords: Backbone resonance assignments; Cytokine; Heteronuclear NMR; Interleukin-1 superfamily; Interleukin-36α