title: [Association between the feeding behavior factors and the expression of DRD2 gene: a study of mexican monozygotic twins].
abstract: BACKGROUND
  The feeding behavior in humans is complex, with psychological, social, and cultural factors. This pathology consists of the desire to eat (reinforcement/reward) and the control of the act of eating (inhibitory control). It is well known that blocking post-synaptic D2 receptors in the nucleus accumbens induces a decrease of craving behavior. Due to this, to test hypothesis we measured the expression of the DRD2 gene and the expression of the type of feeding factor in a group of Mexican twins.
  
  
  METHODS
  In the study were included 18 pairs of twins (n = 36), reared together (at least up to 18 years old); native to Mexico City; to whom we applied the three factors of food instrument.
  
  
  RESULTS
  We observed a significant correlation between the "uncontrolled" factor and expression of the DRD2 gene (p < 0.03).
  
  
  CONCLUSIONS
  Therefore, we propose that the expression of the DRD2 gene in subjects is a linkage to the type of feeding factor.
authors.affiliation: Hospital Infantil Juan N. Navarro, Secretaría de Salud, Ciudad de México, México.|Instituto Nacional de Medicina Genómica (INMEGEN), Ciudad de México, México.
authors.forename: Alma
authors.initials: A
authors.lastname: Genis-Mendoza
authors.affiliation: Instituto Nacional de Medicina Genómica (INMEGEN), Ciudad de México, México.
authors.forename: Humberto
authors.initials: H
authors.lastname: Nicolini
authors.affiliation: Universidad Juárez Autónoma de Tabasco, División Académica Multidisciplinaria de Comalcalco, Comalcalco, Villahermosa, Tab., México.
authors.forename: Carlos Alfonso
authors.initials: CA
authors.lastname: Tovilla-Zárate
authors.affiliation: Hospital General de Yajalón, Secretaría de Salud, Yajalón, Tuxtla Gutiérrez, Chis., México.
authors.forename: María Lilia
authors.initials: ML
authors.lastname: López-Narváez
authors.affiliation: Universidad Juárez Autónoma de Tabasco, División Académica Multidisciplinaria de Jalpa de Méndez, Cunduacán, Villahermosa, Tab., México.
authors.forename: Thelma Beatriz
authors.initials: TB
authors.lastname: González-Castro
mesh_terms: D000328:Adult; D005247:Feeding Behavior / Q000502:physiology*; D005260:Female; D015870:Gene Expression; D006801:Humans; D008297:Male; D008800:Mexico; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D014430:Twins, Monozygotic / Q000235:genetics*; D055815:Young Adult
chemical_list: C581293:DRD2 protein, human; D017448:Receptors, Dopamine D2