title: Elevated interictal serum HSP-70 levels as an indicator of neurodegeneration for chronic migraine.
abstract: To investigate whether there is a relationship between chronic migraine and heat shock protein-70.
  
  
  
  The case-control progressive study was conducted at Ankara Numune Teaching and Research Hospital, Ankara, Turkey, from January to June 2013, and comprised patients over 18 years of age who were diagnosed with chronic migraine and did not have any other known neurological illness. Age and gender-matched volunteers with no history of headache or neurological illness were included as controls. In order to exclude other central nervous system diseases, computed tomography and/or magnetic resonance imaging was carried out. Blood samples to evaluate serum heat shock protein-70 levels were obtained from the patients during headache-free periods and from the controls following 8 hours of fasting. The samples were interpreted using the enzyme-linked immunosorbent assay reader.
  
  
  
  There were 40 controls and an equal number of cases in the study. Mean heat shock protein-70 levels were higher in the cases 2.37±1.91ng/dl compared to thecontrols1.81±1.30 ng/dl, but the difference was not statistically significant (p=0.12). Serum heat shock protein-70 levels were also compared in terms of the duration of migraine disease, frequency of migraine attacks, Visual Analogue Scale score, migraine attack duration and the presence of aura, but no statistically significant difference was found (p=0.13, p=0.17, p=0.90, p=0.68, p=0.95 respectively).
  
  
  
  Heat shock protein-70 was not a reliable chronic migraine biomarker.
authors.affiliation: Ankara Teaching and Research Hospital, Neurology Clinic, Ankara, Turkey.
authors.forename: Mehmet Ilker
authors.initials: MI
authors.lastname: Yon
authors.affiliation: Ankara Numune Teaching and Research Hospital, Neurology Clinic, Ankara, Turkey.
authors.forename: Ayse Pinar
authors.initials: AP
authors.lastname: Titiz
authors.affiliation: Ankara Numune Teaching and Research Hospital, Neurology Clinic, Ankara, Turkey.
authors.forename: Sule
authors.initials: S
authors.lastname: Bilen
authors.affiliation: Develi Hatice Muammer Kocaturk Hospital, Neurology Clinic, Kayseri, Turkey.
authors.forename: Ersin Kasim
authors.initials: EK
authors.lastname: Ulusoy
authors.affiliation: Sivas Numune Hospital, Neurology Clinic, Sivas, Turkey.
authors.forename: Aydin
authors.initials: A
authors.lastname: Gulunay
authors.affiliation: Kahramanmaras Necip Fazil City Hospital, Neurology Clinic, Kahramanmaras, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Karakoc
authors.affiliation: Gazi University School of Medicine, Department of Internal Medicine, Ankara, Turkey.
authors.forename: Merve Ecem Erdogan
authors.initials: ME
authors.lastname: Yon
authors.affiliation: Ankara Numune Teaching and Research Hospital, Neurology Clinic, Ankara, Turkey.
authors.forename: Fikri
authors.initials: F
authors.lastname: Ak
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis*; D016022:Case-Control Studies; D018450:Disease Progression; D004827:Epilepsy; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000032:analysis*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008881:Migraine Disorders / Q000503:physiopathology*; D014421:Turkey
chemical_list: D015415:Biomarkers; D018840:HSP70 Heat-Shock Proteins
keywords: HSP-70, Chronic migraine, Neuro-degeneration.