title: Sperm tsRNAs and acquired metabolic disorders.
abstract: Many findings support the hypothesis that metabolic changes associated with environmental factors can be transmitted from father to offspring. The molecular mechanisms underlying the intergenerational transmission of metabolic changes remain to be fully explored. These acquired metabolic disorders in offspring may be partially explained by some potential epigenetic information carriers such as DNA methylation, histone modification and small non-coding RNAs. Recent evidence shows that sperm tRNA-derived small RNAs (tsRNAs) as a type of paternal epigenetic information carrier may mediate intergenerational inheritance. In this review, we provide current knowledge of a father's influence on metabolic disorders in subsequent generations and discuss the roles of sperm tsRNAs and their modifications in paternal epigenetic information transmission.
authors.affiliation: CAS Key Laboratory of Nutrition and MetabolismCAS Center for Excellence in Molecular Cell Sciences, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
authors.forename: Menghong
authors.initials: M
authors.lastname: Yan
authors.affiliation: CAS Key Laboratory of Nutrition and MetabolismCAS Center for Excellence in Molecular Cell Sciences, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China School of Life Science and TechnologyShanghaiTech University, Shanghai, China qwzhai@sibs.ac.cn.
authors.forename: Qiwei
authors.initials: Q
authors.lastname: Zhai
mesh_terms: D000818:Animals; D019175:DNA Methylation / Q000235:genetics; D044127:Epigenesis, Genetic / Q000235:genetics; D006801:Humans; D008297:Male; D008659:Metabolic Diseases / Q000235:genetics*; D012313:RNA / Q000235:genetics*; D013094:Spermatozoa / Q000378:metabolism*
chemical_list: D012313:RNA
keywords: RNA modification; acquired metabolic disorder; intergenerational inheritance; tsRNA