title: Collectin Liver 1 and Collectin Kidney 1 of the Lectin Complement Pathway Are Associated With Mortality After Kidney Transplantation.
abstract: Kidney transplanted patients still have significantly higher mortality compared with the general population. The innate immune system may play an important role during periods, with suppression of the adaptive immune system. In the present study, two soluble pattern recognition molecules of the innate immune system were investigated, collectin liver 1 (CL-L1) and collectin kidney 1 (CL-K1). Potential associations of their pretransplant levels and long-term graft and recipient survival were examined. The levels of CL-L1 and CL-K1 were measured at the time of transplantation in 382 patients (≥17 years) transplanted in 2000-2001. The cohort was subsequently followed until December 31, 2014. Data on patient and graft survival were obtained from the Norwegian Renal Registry. Both high CL-L1 (≥376 ng/mL) and high CL-K1 (≥304 ng/mL) levels were significantly associated with overall mortality in multivariate Cox analyses with hazard ration (HR) 1.50, 95% confidence interval (CI) 1.09-2.07, p = 0.013 and HR 1.43, 95% CI 1.02-1.99, p = 0.038, respectively. Moreover, high CL-K1 levels were significantly associated with cardiovascular mortality. No association between measured biomarkers and death-censored graft loss was found. Finally, there was a significant correlation between these two collectins, r = 0.83 (95% CI 0.80-0.86). In conclusion, CL-L1 and CL-K1 were significantly associated with mortality in kidney transplant recipients.
authors.affiliation: Department of Nephrology, Ullevål Oslo University Hospital, Oslo, Norway.|Faculty of Medicine, University of Oslo, Oslo, Norway.
authors.forename: J
authors.initials: J
authors.lastname: Smedbråten
authors.affiliation: Department of Nephrology, Ullevål Oslo University Hospital, Oslo, Norway.
authors.forename: S
authors.initials: S
authors.lastname: Sagedal
authors.affiliation: Department of Transplant Medicine, Rikshospitalet Oslo University Hospital, Oslo, Norway.|Norwegian Renal Registry, Oslo University Hospital, Oslo, Norway.|School of Pharmacy, University of Oslo, Oslo, Norway.
authors.forename: A
authors.identifier: 0000-0002-0628-1769
authors.initials: A
authors.lastname: Åsberg
authors.affiliation: Faculty of Medicine, University of Oslo, Oslo, Norway.|Department of Transplant Medicine, Rikshospitalet Oslo University Hospital, Oslo, Norway.
authors.forename: A
authors.initials: A
authors.lastname: Hartmann
authors.affiliation: Faculty of Medicine, University of Oslo, Oslo, Norway.|Department of Microbiology, Rikshospitalet Oslo University Hospital, Oslo, Norway.
authors.forename: H
authors.initials: H
authors.lastname: Rollag
authors.affiliation: Department of Transplant Medicine, Rikshospitalet Oslo University Hospital, Oslo, Norway.
authors.forename: G
authors.initials: G
authors.lastname: Mjøen
authors.affiliation: Oslo Centre for Biostatistics and Epidemiology, Research Support Services, Oslo University Hospital, Oslo, Norway.
authors.forename: M W
authors.initials: MW
authors.lastname: Fagerland
authors.affiliation: Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
authors.forename: S W K
authors.initials: SW
authors.lastname: Hansen
authors.affiliation: Faculty of Medicine, University of Oslo, Oslo, Norway.|Department of Immunology, Oslo University Hospital Rikshospitalet and K. G. Jebsen IRC, University of Oslo, Oslo, Norway.|Research Laboratory, Nordland Hospital, Bodø, Norway.|Faculty of Health Sciences, K. G. Jebsen TREC, University of Tromsø, Tromsø, Norway.|Center of Molecular Inflammation Research, Norwegian University of Science and Technology, Trondheim, Norway.
authors.forename: T E
authors.initials: TE
authors.lastname: Mollnes
authors.affiliation: Department of Biomedicine, Aarhus University, Aarhus, Denmark.
authors.forename: S
authors.initials: S
authors.lastname: Thiel
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000209:etiology / Q000401:mortality*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D037222:Collectins / Q000378:metabolism*; D037582:Complement Pathway, Mannose-Binding Lectin; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000209:etiology / Q000401:mortality*; D006085:Graft Survival; D006801:Humans; D007223:Infant; D007676:Kidney Failure, Chronic / Q000601:surgery*; D007677:Kidney Function Tests; D016030:Kidney Transplantation / Q000009:adverse effects / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors; D015996:Survival Rate; D055815:Young Adult
chemical_list: C445459:COLEC10 protein, human; C518521:Colec11 protein, human; D037222:Collectins
keywords: basic (laboratory) research / science; biomarker; clinical research / practice; complement biology; graft survival; innate immunity; kidney transplantation / nephrology; patient survival