title: [Increased expressions of Blimp-1 and Bcl-6 in the deciduas of patients with unexplained recurrent spontaneous abortion].
abstract: Objective To oberseve the expressions of B cell lymphoma 6 (Bcl-6) and B lymphocyte-induced maturation protein 1 (Blimp-1) in the decidua of patients with unexplained recurrent spontaneous abortion (URSA), and investigate the roles that Bcl-6 and Blimp-1 act in URSA. Methods Decidual tissues were collected from patients with URSA (URSA group) and normal pregnant women (control group). Then, we detected the expressions of Bcl-6 and Blimp-1 in the deciduas of the two groups using real-time fluorescent quantitative PCR and immunohistochemistry. The relationship between Blimp-1 and Bcl-6 was estimated by Pearson's correlation analysis. Results Compared with the control group, the levels of Blimp-1 mRNA and protein, Bcl-6 mRNA significantly increased in the URSA group. However, Bcl-6 protein was raised insignificantly in URSA group. Furthermore, there was a positive correlation between Bcl-6 and Blimp-1 at the level of mRNA. Conclusion The expressions of Bcl-6 and Blimp-1 are enhanced in the deciduas of URSA patients.
authors.affiliation: Reproductive Medicine Center, First Affiliated Hospital, Xinjiang Medical University, Department of Immunology, School of Preclinical Medicine, Xinjiang Medical University, Urumqi 830011, China.
authors.forename: Qiaoqiao
authors.initials: Q
authors.lastname: Gong
authors.affiliation: Reproductive Medicine Center, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830011, China.
authors.forename: Yuejie
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Immunology, School of Preclinical Medicine, Xinjiang Medical University, Urumqi 830011, China.
authors.forename: Pan
authors.initials: P
authors.lastname: Pang
authors.affiliation: Department of Immunology, School of Preclinical Medicine, Xinjiang Medical University, Urumqi 830011, China.
authors.forename: Yuhong
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Reproductive Medicine Center, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830011, China.
authors.forename: Junda
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Reproductive Medicine Center, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830011, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Reproductive Medicine Center, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830011, China. *Corresponding authors, E-mail: djbing002@sina.com.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: LA
authors.affiliation: Department of Immunology, School of Preclinical Medicine, Xinjiang Medical University, Urumqi 830011, China. *Corresponding authors, E-mail: 2022498255@qq.com.
authors.forename: Jianbing
authors.initials: J
authors.lastname: Ding
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D003656:Decidua / Q000378:metabolism*; D005260:Female; D015870:Gene Expression; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry; D000074462:Positive Regulatory Domain I-Binding Factor 1; D011247:Pregnancy; D051560:Proto-Oncogene Proteins c-bcl-6 / Q000235:genetics* / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics* / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D055815:Young Adult
chemical_list: C084103:BCL6 protein, human; D051560:Proto-Oncogene Proteins c-bcl-6; D012333:RNA, Messenger; D012097:Repressor Proteins; C087042:PRDM1 protein, human; D000074462:Positive Regulatory Domain I-Binding Factor 1