title: [The neurovascular unit in health and ischemic stroke].
abstract: The neurovascular unit (NVU), a minimal unit to exert neurological functions, is composed of neurons, astrocytes, endothelial cells, pericytes, and extracellular matrix proteins forming basal membranes. The cell components interact with one another and function cooperatively under both physiological and pathological conditions. Pericytes and astrocytes participate crucially in the formation and maintenance of the blood-brain barrier (BBB), the tight junction formed by endothelial cells, and regulate cerebral blood flow in response to neurological activities. The BBB actively regulate molecular import and export. The concept of the NVU is also useful for understanding pathogenesis and exploring therapeutic targets in various CNS disorders. In this review, recent research advances regarding the NVU and its components in health and ischemic stroke are summarized.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Ago
mesh_terms: D001253:Astrocytes / Q000502:physiology*; D001812:Blood-Brain Barrier / Q000502:physiology*; D002450:Cell Communication / Q000502:physiology; D002465:Cell Movement; D002560:Cerebrovascular Circulation / Q000502:physiology; D042783:Endothelial Cells / Q000502:physiology*; D005109:Extracellular Matrix / Q000502:physiology; D006801:Humans; D058990:Molecular Targeted Therapy; D020286:Pericytes / Q000502:physiology*; D020521:Stroke / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D019108:Tight Junctions / Q000502:physiology