title: Chemical probes for methyl lysine reader domains.
abstract: The primary intent of a chemical probe is to establish the relationship between a molecular target, usually a protein whose function is modulated by the probe, and the biological consequences of that modulation. In order to fulfill this purpose, a chemical probe must be profiled for selectivity, mechanism of action, and cellular activity, as the cell is the minimal system in which 'biology' can be explored. This review provides a brief overview of progress towards chemical probes for methyl lysine reader domains with a focus on recent progress targeting chromodomains.
authors.affiliation: Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, 125 Mason Farm Road, Marsico Hall, UNC-Chapel Hill, NC 27599-7363, United States.
authors.forename: Lindsey I
authors.initials: LI
authors.lastname: James
authors.affiliation: Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, 125 Mason Farm Road, Marsico Hall, UNC-Chapel Hill, NC 27599-7363, United States. Electronic address: svfrye@email.unc.edu.
authors.forename: Stephen V
authors.initials: SV
authors.lastname: Frye
mesh_terms: D006801:Humans; D008239:Lysine / Q000737:chemistry*; D008745:Methylation; D008958:Models, Molecular; D018716:Molecular Mimicry; D015335:Molecular Probes / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry
chemical_list: D015335:Molecular Probes; D010455:Peptides; D008239:Lysine