title: Platinum-catalyzed cycloisomerizations of a common enyne: a divergent entry to cyclopropane sesquiterpenoids. Formal synthesis of sarcandralactone A.
abstract: A common enyne scaffold, resembling the structures of natural elemanes was found to be an excellent substrate for highly regioselective cycloisomerizations to produce diverse cyclopropane sesquiterpenoids. Platinum-catalysis was utilized to produce either lindenane or myliol cores, found in natural products, starting from enyne acetate 10 and its corresponding allene 12 respectively. Based on this concept, a second generation strategy allows the formal synthesis of sarcandralactone A.
authors.affiliation: Department of Chemistry, Laboratory of Organic Chemistry, Aristotle University of Thessaloniki, University Campus, 54124, Thessaloniki, Greece. alzograf@chem.auth.gr.
authors.forename: Vera P
authors.initials: VP
authors.lastname: Demertzidou
authors.forename: Alexandros L
authors.initials: AL
authors.lastname: Zografos
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D061565:Cycloaddition Reaction; D003521:Cyclopropanes / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D010984:Platinum / Q000737:chemistry*; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D003521:Cyclopropanes; D012717:Sesquiterpenes; D010984:Platinum; C030797:cyclopropane