title: Brønsted acid-catalyzed regioselective reactions of 2-indolylmethanols with cyclic enaminone and anhydride leading to C3-functionalized indole derivatives.
abstract: An abnormal regioselective substitution of 2-indolylmethanols with nucleophiles such as cyclic enaminone and cyclic anhydride has been established in the presence of Brønsted acid, which efficiently afforded C3-functionalized indole derivatives with structural diversity in high yield and regiospecificity (40 examples, up to 99% yield). Using this approach, the reactivity of the C3-position of the indole was switched from nucleophilic to electrophilic, which could serve as an "umpolung" strategy in organic synthesis.
authors.affiliation: School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou, 221116, China. fshi@jsnu.edu.cn.
authors.forename: Can
authors.initials: C
authors.lastname: Li
authors.forename: Hong-Hao
authors.initials: HH
authors.lastname: Zhang
authors.forename: Tao
authors.initials: T
authors.lastname: Fan
authors.forename: Yang
authors.initials: Y
authors.lastname: Shen
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wu
authors.forename: Feng
authors.initials: F
authors.lastname: Shi