title: Isolation and anti-HIV-1 integrase activity of lentzeosides A-F from extremotolerant lentzea sp. H45, a strain isolated from a high-altitude Atacama Desert soil.
abstract: The extremotolerant isolate H45 was one of several actinomycetes isolated from a high-altitude Atacama Desert soil collected in northwest Chile. The isolate was identified as a new Lentzea sp. using a combination of chemotaxonomic, morphological and phylogenetic properties. Large scale fermentation of the strain in two different media followed by chromatographic purification led to the isolation of six new diene and monoene glycosides named lentzeosides A-F, together with the known compound (Z)-3-hexenyl glucoside. The structures of the new compounds were confirmed by HRESIMS and NMR analyses. Compounds 1-6 displayed moderate inhibitory activity against HIV integrase.
authors.affiliation: Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Scotland, UK.|Department of Chemistry, University of Regensburg, Universitätsstraße 31, Regensburg, Germany.
authors.forename: Dominik
authors.initials: D
authors.lastname: Wichner
authors.affiliation: School of Biology, Newcastle University, Newcastle upon Tyne, UK.
authors.forename: Hamidah
authors.initials: H
authors.lastname: Idris
authors.affiliation: Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Scotland, UK.|Institute of Medical Sciences, University of Aberdeen, Scotland, UK.|Faculty of Pharmacy, Department of Pharmacognosy, Mansoura University, Mansoura, Egypt.
authors.forename: Wael E
authors.initials: WE
authors.lastname: Houssen
authors.affiliation: Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Scotland, UK.|Institute of Medical Sciences, University of Aberdeen, Scotland, UK.
authors.forename: Andrew R
authors.initials: AR
authors.lastname: McEwan
authors.affiliation: School of Biosciences, University of Kent, Kent, UK.
authors.forename: Alan T
authors.initials: AT
authors.lastname: Bull
authors.affiliation: Centre for Biotechnology and Bioengineering (CeBiB), Department of Chemical Engineering and Biotechnology, Universidad de Chile, Santiago, Chile.
authors.forename: Juan A
authors.initials: JA
authors.lastname: Asenjo
authors.affiliation: School of Biology, Newcastle University, Newcastle upon Tyne, UK.
authors.forename: Michael
authors.initials: M
authors.lastname: Goodfellow
authors.affiliation: Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Scotland, UK.
authors.forename: Marcel
authors.initials: M
authors.lastname: Jaspars
authors.affiliation: Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Scotland, UK.
authors.forename: Rainer
authors.initials: R
authors.lastname: Ebel
authors.affiliation: Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Scotland, UK.|School of Science & Sport, University of the West of Scotland, Paisley, UK.|Department of Pharmacognosy, School of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
authors.forename: Mostafa E
authors.initials: ME
authors.lastname: Rateb
mesh_terms: D000192:Actinomycetales / Q000737:chemistry* / Q000145:classification / Q000235:genetics; D000531:Altitude; D002677:Chile; D003889:Desert Climate; D005285:Fermentation; D019428:HIV Integrase Inhibitors / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects* / Q000201:enzymology*; D009682:Magnetic Resonance Spectroscopy; D012331:RNA, Fungal / Q000235:genetics; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D012988:Soil Microbiology; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D019428:HIV Integrase Inhibitors; D012331:RNA, Fungal; D012336:RNA, Ribosomal, 16S