title: Vitamin D Status in Infants with Two Different Wheezing Phenotypes.
abstract: OBJECTIVE
  To investigate vitamin D levels in patients with recurrent wheeze at early ages of childhood.
  
  
  METHODS
  In the present cross-sectional study, serum 25-hydroxy vitamin D [25 (OH)D], levels which is known as an indicator of vitamin D adequacy, was examined in infants with three or more wheezing attacks.
  
  
  RESULTS
  A total of 186 infants with recurrent wheezing were included in the study along with 118 healthy control peers. The recurrent wheezing study participants were classified into two groups according to Asthma Predictive Index (API) positivity and compared to control subjects regarding their serum vitamin D status. The API negative group had the lowest mean serum 25 (OH)D level (n = 121; 22.71 ± 10.76 ng/ml) followed by API positive group (n = 65; 24.08 ± 9.02 ng/ml) compared to healthy group (26.24 ± 11.88 ng/ml) (p < 0.05). In addition, higher vitamin D deficiency was observed in infants in API negative group (52.1 %; p < 0.01) and API positive group (38.5 %; p < 0.05) than control group (31.4 %).
  
  
  CONCLUSIONS
  Low levels of 25 (OH)D were detected in infants with two different phenotypes of recurrent wheeze. Vitamin D deficiency may play a role in the pathogenesis of infants with recurrent wheezing.
authors.affiliation: Pediatric Pulmonary Section, Department of Pediatrics, Mersin Children's Hospital, Halkkent, 33240, Mersin, Turkey. aliozdemir@hotmail.com.
authors.forename: Ali
authors.initials: A
authors.lastname: Ozdemir
authors.affiliation: Pediatric Allergy & Immunology Section, Department of Pediatrics, University of Baskent, Adana, Turkey.
authors.forename: Dilek
authors.initials: D
authors.lastname: Dogruel
authors.affiliation: Pediatric Allergy & Immunology Section, Department of Pediatrics, Mersin Children's Hospital, Halkkent, Mersin, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Yilmaz
mesh_terms: D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010641:Phenotype; D012135:Respiratory Sounds; D014807:Vitamin D; D014808:Vitamin D Deficiency
chemical_list: D014807:Vitamin D
keywords: Allergic sentisization; Asthma predictive index; Recurrent wheezing; Vitamin D