title: Predictive value of platelet-to-lymphocyte ratio in exacerbation of chronic obstructive pulmonary disease.
abstract: OBJECTIVE
  We aimed to assess the platelet-to-lymphocyte ratio (PLR) and platelet parameters in patients with chronic obstructive pulmonary disease (COPD).
  
  
  METHODS
  A total of 60 stable COPD patients, 50 acute exacerbation COPD patients and 50 healthy controls were enrolled in this study.
  
  
  RESULTS
  The platelet distribution width and PLR were higher and the mean platelet volume was lower in the COPD patients during acute exacerbation compared with the stable patients and controls. The PLR was negatively correlated with the forced expiratory volume in 1 s.
  
  
  CONCLUSIONS
  The PLR may be used as a useful and easily accessible tool for evaluating the ongoing inflammation during stable period and the disease severity during acute exacerbations in COPD patients.
authors.affiliation: Dr Suat Seren Chest Disease & Surgery Training & Research Hospital, Department of Pulmonology, Izmir, Turkey.
authors.forename: Gülistan
authors.initials: G
authors.lastname: Karadeniz
authors.affiliation: Dr Suat Seren Chest Disease & Surgery Training & Research Hospital, Department of Pulmonology, Izmir, Turkey.
authors.forename: Serir
authors.initials: S
authors.lastname: Aktoğu
authors.affiliation: Dr Suat Seren Chest Disease & Surgery Training & Research Hospital, Department of Pulmonology, Izmir, Turkey.
authors.forename: Onur Fevzi
authors.initials: OF
authors.lastname: Erer
authors.affiliation: Sifa University School of Medicine, Department of Pulmonology, Izmir, Turkey.
authors.forename: Serpil Bulaç
authors.initials: SB
authors.lastname: Kır
authors.affiliation: Sifa University School of Medicine, Department of Pulmonology, Izmir, Turkey.
authors.forename: Sibel
authors.initials: S
authors.lastname: Doruk
authors.affiliation: Dicle University School of Medicine, Department of Pulmonology, Diyarbakır, Turkey.
authors.forename: Melike
authors.initials: M
authors.lastname: Demir
authors.affiliation: Dokuz Eylul University Faculty of Health Sciences, Department of Nursing, Izmir, Turkey.
authors.forename: Kübra
authors.initials: K
authors.lastname: Sonat
mesh_terms: D000368:Aged; D019540:Area Under Curve; D001792:Blood Platelets / Q000166:cytology* / Q000502:physiology; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008214:Lymphocytes / Q000166:cytology*; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D011237:Predictive Value of Tests; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis* / Q000473:pathology; D012372:ROC Curve; D012907:Smoking
chemical_list: D002097:C-Reactive Protein
keywords: chronic obstructive pulmonary disease; mean platelet volume; platelet-to-lymphocyte ratio