title: Alkaline Water and Longevity: A Murine Study.
abstract: The biological effect of alkaline water consumption is object of controversy. The present paper presents a 3-year survival study on a population of 150 mice, and the data were analyzed with accelerated failure time (AFT) model. Starting from the second year of life, nonparametric survival plots suggest that mice watered with alkaline water showed a better survival than control mice. Interestingly, statistical analysis revealed that alkaline water provides higher longevity in terms of "deceleration aging factor" as it increases the survival functions when compared with control group; namely, animals belonging to the population treated with alkaline water resulted in a longer lifespan. Histological examination of mice kidneys, intestine, heart, liver, and brain revealed that no significant differences emerged among the three groups indicating that no specific pathology resulted correlated with the consumption of alkaline water. These results provide an informative and quantitative summary of survival data as a function of watering with alkaline water of long-lived mouse models.
authors.affiliation: Department of Comparative Biomedicine and Food Science, University of Padua, 35020 Legnaro, Italy.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Magro
authors.affiliation: Department of Management and Engineering, University of Padua, 36100 Vicenza, Italy.
authors.forename: Livio
authors.initials: L
authors.lastname: Corain
authors.affiliation: Department of Comparative Biomedicine and Food Science, University of Padua, 35020 Legnaro, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Ferro
authors.affiliation: Department of Comparative Biomedicine and Food Science, University of Padua, 35020 Legnaro, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Baratella
authors.affiliation: Department of Comparative Biomedicine and Food Science, University of Padua, 35020 Legnaro, Italy.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Bonaiuto
authors.affiliation: Department of Comparative Biomedicine and Food Science, University of Padua, 35020 Legnaro, Italy.
authors.forename: Milo
authors.initials: M
authors.lastname: Terzo
authors.affiliation: Department of Comparative Biomedicine and Food Science, University of Padua, 35020 Legnaro, Italy.
authors.forename: Vittorino
authors.initials: V
authors.lastname: Corraducci
authors.affiliation: Department of Management and Engineering, University of Padua, 36100 Vicenza, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Salmaso
authors.affiliation: Department of Comparative Biomedicine and Food Science, University of Padua, 35020 Legnaro, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Vianello