title: Inflammation and Progression of CKD: The CRIC Study.
abstract: CKD is a global public health problem with significant mortality and morbidity.
  
  
  
  We examined the multivariable association of plasma levels of IL-1, IL-1 receptor antagonist, IL-6, TNF-α, TGF-β, high-sensitivity C-reactive protein, fibrinogen, and serum albumin with progression of CKD in 3430 Chronic Renal Insufficiency Cohort study participants.
  
  
  
  Over a median follow-up time of 6.3 years, 899 participants reached the composite end point of ≥50% decline in eGFR from baseline or onset of ESRD. Elevated plasma levels of fibrinogen, IL-6, and TNF-α and lower serum albumin were associated with a greater decline in eGFR over time. After adjusting for demographics, BP, laboratory variables, medication use, and baseline eGFR, hazard ratios for the composite outcome were greater for the patients in the highest quartile of fibrinogen (hazard ratio, 2.05; 95% confidence interval, 1.64 to 2.55; P<0.001), IL-6 (hazard ratio, 1.44; 95% confidence interval, 1.17 to 1.77; P<0.01), and TNF-α (hazard ratio, 1.94; 95% confidence interval, 1.52 to 2.47; P<0.001) compared with those in the respective lowest quartiles. The hazard ratio was 3.48 (95% confidence interval, 2.88 to 4.21; P<0.001) for patients in the lowest serum albumin quartile relative to those in the highest quartile. When also adjusted for albuminuria, the associations of fibrinogen (hazard ratio, 1.49; 95% confidence interval, 1.20 to 1.86; P<0.001), serum albumin (hazard ratio, 1.52; 95% confidence interval, 1.24 to 1.87; P<0.001), and TNF-α (hazard ratio, 1.42; 95% confidence interval, 1.11 to 1.81; P<0.001) with outcome were attenuated but remained significant.
  
  
  
  Elevated plasma levels of fibrinogen and TNF-α and decreased serum albumin are associated with rapid loss of kidney function in patients with CKD.
authors.affiliation: Due to the number of contributing authors, the affiliations are provided in the Supplemental Material .
authors.forename: Richard L
authors.initials: RL
authors.lastname: Amdur
authors.forename: Harold I
authors.initials: HI
authors.lastname: Feldman
authors.forename: Jayanta
authors.initials: J
authors.lastname: Gupta
authors.forename: Wei
authors.initials: W
authors.lastname: Yang
authors.forename: Peter
authors.initials: P
authors.lastname: Kanetsky
authors.forename: Michael
authors.initials: M
authors.lastname: Shlipak
authors.forename: Mahboob
authors.initials: M
authors.lastname: Rahman
authors.forename: James P
authors.initials: JP
authors.lastname: Lash
authors.forename: Raymond R
authors.initials: RR
authors.lastname: Townsend
authors.forename: Akinlolu
authors.initials: A
authors.lastname: Ojo
authors.forename: Akshay
authors.initials: A
authors.lastname: Roy-Chaudhury
authors.forename: Alan S
authors.initials: AS
authors.lastname: Go
authors.forename: Marshall
authors.initials: M
authors.lastname: Joffe
authors.forename: Jiang
authors.initials: J
authors.lastname: He
authors.forename: Vaidyanathapuram S
authors.initials: VS
authors.lastname: Balakrishnan
authors.forename: Paul L
authors.initials: PL
authors.lastname: Kimmel
authors.forename: John W
authors.initials: JW
authors.lastname: Kusek
authors.forename: Dominic S
authors.initials: DS
authors.lastname: Raj
mesh_terms: D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D016207:Cytokines / Q000097:blood*; D018450:Disease Progression; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000150:complications*; D007375:Interleukin-1 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D007676:Kidney Failure, Chronic / Q000209:etiology; D008297:Male; D008875:Middle Aged; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000150:complications* / Q000503:physiopathology*; D012709:Serum Albumin / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D016207:Cytokines; D007375:Interleukin-1; D015850:Interleukin-6; D012709:Serum Albumin; D016212:Transforming Growth Factor beta; D014409:Tumor Necrosis Factor-alpha; D005340:Fibrinogen; D002097:C-Reactive Protein
keywords: C-Reactive Protein; Follow-Up Studies; Humans; Inflammation; Interleukin-6; Renal Insufficiency, Chronic; Tumor Necrosis Factor-alpha; albuminuria; chronic kidney disease; cytokines; end-stage renal disease; glomerular filtration rate