title: Acute respiratory distress syndrome in adenovirus type 4 pneumonia: A case report.
abstract: Human adenoviruses (HAdVs) cause a wide spectrum of clinical syndromes, depending on species and types, from mild respiratory infections to deadly pneumonia: in particular, severe infections occur in immunocompromised patients. In this report, we describe the case of a 36 years-old woman admitted to our intensive care unit (ICU) with severe respiratory distress syndrome caused by adenovirus pneumonia, that required invasive respiratory support (mechanical ventilation and extracorporeal membrane oxygenation). Molecular assays detected the virus in respiratory and plasma specimen and sequencing procedure identified HAdV type 4. Patient improved after cidofovir administration. Leukopenia and subsequent bacterial infection occurred, but the patient recovered completely and was discharged from the hospital after 54days.
authors.affiliation: Virology Unit, Fondazione IRCCS Ospedale Maggiore Ca' Granda, Milan, Italy;, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Narra
authors.affiliation: Virology Unit, Fondazione IRCCS Ospedale Maggiore Ca' Granda, Milan, Italy;, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Bono
authors.affiliation: Virology Unit, Fondazione IRCCS Ospedale Maggiore Ca' Granda, Milan, Italy;, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Zoccoli
authors.affiliation: Virology Unit, Fondazione IRCCS Ospedale Maggiore Ca' Granda, Milan, Italy;, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Orlandi
authors.affiliation: First Infectious Disease Department, A.O. Luigi Sacco, Milan, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Piconi
authors.affiliation: Intensive Care Unit, Fondazione IRCCS Ospedale Maggiore Ca' Granda, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Grasselli
authors.affiliation: Intensive Care Unit, Fondazione IRCCS Ospedale Maggiore Ca' Granda, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Crotti
authors.affiliation: Molecular Virology Unit, Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Girello
authors.affiliation: Molecular Virology Unit, Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Piralla
authors.affiliation: Molecular Virology Unit, Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Section of Microbiology, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Baldanti
authors.affiliation: Virology Unit, Fondazione IRCCS Ospedale Maggiore Ca' Granda, Milan, Italy;, Italy. Electronic address: giovanna.lunghi@policlinico.mi.it.
authors.forename: G
authors.initials: G
authors.lastname: Lunghi
mesh_terms: D000258:Adenovirus Infections, Human; D000260:Adenoviruses, Human / Q000235:genetics*; D000328:Adult; D003422:Critical Care; D004279:DNA, Viral / Q000032:analysis / Q000235:genetics; D005260:Female; D006760:Hospitalization; D006801:Humans; D058889:Molecular Typing; D016133:Polymerase Chain Reaction; D012128:Respiratory Distress Syndrome
chemical_list: D004279:DNA, Viral
keywords: Adenoviral pneumonia; Adenovirus; Infectious disease; Intensive care unit; Polymerase chain reaction (PCR)