title: Triterpenes in cancer: significance and their influence.
abstract: Natural products are enriched with numerous compounds with a broad spectrum of therapeutics indication suggesting the role of functional moieties as a core pharmacophore. This review highlights the role of triterpene in targeting signaling pathways in cancer. Advancement in cellular, biochemical, experimental, and computational approaches provides new insights into various pathways in cancer. In signaling network, triterpenes primarily target membrane receptors which control and modulates expression level of the biological responses. Triterpenes are immunomodulatory targeting nuclear factor kappa B, toll-like receptors, signal transducer and activator of transcription 3, and PI3K/Akt/mTOR. Triterpenes isolated from plants and fungus mainly focus on the process of apoptosis while other signaling areas in the cancer are still shrouded. Some of the triterpenes have already passed the clinical trial, whereas many more have been proven to yield effective results. This review would help the researchers to study the role of triterpenes in cancer, thus, helping them to discover and design efficacious therapeutics agents.
authors.affiliation: Centre for Biosciences, Central University of Punjab, Bathinda, 151001, India.
authors.forename: Balraj Singh
authors.initials: BS
authors.lastname: Gill
authors.affiliation: Centre for Plant Sciences, Central University of Punjab, Bathinda, 151001, India.
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Kumar
authors.affiliation: Centre for Biotechnology, HMV College Jalandhar, Jalandhar, Punjab, India. geet20capricorn@gmail.com.
authors.lastname: Navgeet
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D015398:Signal Transduction; D014315:Triterpenes / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes
keywords: Clinical trials; Ganoderma lucidum; PI3K/Akt/mTOR pathway; Receptor tyrosine kinase; Triterpenes