title: Data related to inflammation and cholesterol deposition triggered by macrophages exposition to modified LDL.
abstract: This article supports experimental evidence on the time-dependent effect on gene expression related to inflammation and cholesterol deposition in lipid-loaded cells. The cells employed were human monocytes THP1 line transformed into macrophages by treatment with phorbol esters. Macrophages were treated at different times with oxidized low density lipoprotein (Ox-LDL) and then gene expression was measured. We also include data about the different types of oxidized lipoprotein obtained (low, media or high oxidation) for differential exposure with Cu ions. These data include characterization to lipid and protein peroxidative damage and also quantification of cell viability by exposure to native and modified LDL. The present article complements data published in "Decreased OxLDL uptake and cholesterol efflux in THP1 cells elicited by cortisol and by cortisone through 11β-hydroxysteroid dehydrogenase type 1" Ledda et al. (in press) [1].
authors.affiliation: INIBIOLP-CONICET, Facultad Cs. Médicas, Universidad Nacional de La Plata, La Plata, Argentina.
authors.forename: Juan
authors.initials: J
authors.lastname: Toledo
authors.affiliation: Department of Nutrition and Food Sciences, Faculty of Biology, University of Barcelona, Barcelona, Spain; CIBER Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Esteve
authors.affiliation: Department of Nutrition and Food Sciences, Faculty of Biology, University of Barcelona, Barcelona, Spain; CIBER Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain.
authors.forename: Mar
authors.initials: M
authors.lastname: Grasa
authors.affiliation: Department of Nutrition and Food Sciences, Faculty of Biology, University of Barcelona, Barcelona, Spain; CIBER Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain.
authors.forename: Angelo
authors.initials: A
authors.lastname: Ledda
authors.affiliation: INIBIOLP-CONICET, Facultad Cs. Médicas, Universidad Nacional de La Plata, La Plata, Argentina.
authors.forename: Horacio
authors.initials: H
authors.lastname: Garda
authors.affiliation: Department of Nutrition and Food Sciences, Faculty of Biology, University of Barcelona, Barcelona, Spain; CIBER Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain.
authors.forename: José
authors.initials: J
authors.lastname: Gulfo
authors.affiliation: INIBIOLP-CONICET, Facultad Cs. Médicas, Universidad Nacional de La Plata, La Plata, Argentina.
authors.forename: Ivo Díaz
authors.initials: ID
authors.lastname: Ludovico
authors.affiliation: INIBIOLP-CONICET, Facultad Cs. Médicas, Universidad Nacional de La Plata, La Plata, Argentina.
authors.forename: Nahuel
authors.initials: N
authors.lastname: Ramella
authors.affiliation: INIBIOLP-CONICET, Facultad Cs. Médicas, Universidad Nacional de La Plata, La Plata, Argentina.
authors.forename: Marina
authors.initials: M
authors.lastname: Gonzalez
keywords: Cell viability; Low density lipoprotein; Macrophages; Peroxidative damage