title: Identification of ubiquinol cytochrome c reductase hinge (UQCRH) as a potential diagnostic biomarker for lung adenocarcinoma.
abstract: Ubiquinol cytochrome c reductase hinge (UQCRH) is a novel protein that localizes in the mitochondrial membrane and induces mitochondrial reactive oxygen species (ROS) generation. It had a high expression rate of 87.10% (108/124) in lung adenocarcinoma. Moreover, serum UQCRH level in patients with lung adenocarcinoma was significantly increased compared with that of pneumonia patients (p < 0.0001) and normal control subjects (p < 0.0001). Receiver operating characteristic curve analysis using an optimal cut-off value of 162.65 pg ml(-1) revealed sensitivity and specificity for the diagnosis of lung adenocarcinoma of 88.7% and 85.7%, respectively, with an area under the curve of 0.927 (95% CI: 0.892 to 0.962, p < 0.0001). Serum UQCRH discriminates lung adenocarcinoma patients from the population without cancer with considerable sensitivity and specificity, but it does not distinguish between heavy smokers and lung adenocarcinoma patients. Serum UQCRH could be a potential diagnostic biomarker for lung adenocarcinoma.
authors.affiliation: Department of Pathology, Fujian Medical University, Fuzhou 350005, People's Republic of China.
authors.forename: Feng
authors.initials: F
authors.lastname: Gao
authors.affiliation: Department of Laboratory Medicine, Fujian Medical University, Fuzhou 350005, People's Republic of China.
authors.forename: Qicai
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Department of Pathology, Fujian Medical University, Fuzhou 350005, People's Republic of China.
authors.forename: Guoping
authors.initials: G
authors.lastname: Li
authors.affiliation: Department of Radiation Oncology, Fujian Medical University, Fuzhou 350005, People's Republic of China.
authors.forename: Feng
authors.initials: F
authors.lastname: Dong
authors.affiliation: Department of Chest Surgery, Fujian Medical University, Fuzhou 350005, People's Republic of China.
authors.forename: Minglian
authors.initials: M
authors.lastname: Qiu
authors.affiliation: Department of Respiratory, the First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, People's Republic of China.
authors.forename: Xiaoting
authors.initials: X
authors.lastname: Lv
authors.affiliation: Department of Pathology, Fujian Medical University, Fuzhou 350005, People's Republic of China zhgshg@126.com.
authors.forename: Sheng
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Bioinformatics, Fujian Medical University, Fuzhou 350005, People's Republic of China markzguo@163.com.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Guo
mesh_terms: D000230:Adenocarcinoma / Q000097:blood*; D000077192:Adenocarcinoma of Lung; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D014450:Electron Transport Complex III / Q000097:blood*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000097:blood; D012372:ROC Curve; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; C039762:UQCRH protein, human; D014450:Electron Transport Complex III
keywords: lung adenocarcinoma; mitochondrial membrane potential; serum biomarker; ubiquinol-cytochrome c reductase hinge