title: [Study of the effects of three luteal phase supporting strategies on clinical outcomes of intrauterine insemination].
abstract: OBJECTIVE
  To explore the effects of three luteal phase supporting strategies on clinical outcomes of intrauterine insemination (IUI).
  
  
  METHODS
  1 779 subjects who underwent IUI at the Center of Reproductive Medicine, Peking University Third Hospital from November 2014 to June 2015 were enrolled in this retrospectively study.According to the luteal phase supporting strategies, all the subjects were divided into three groups: subjects receiving Dydrogesterone were group A; subjects receiving oral micronized progesterone were group B; subjects receiving vaginal micronized progesterone were group C. The pregnancy outcomes, including clinical pregnancy rate, early miscarriage rate, biochemical pregnancy rate and ectopic pregnancy rate were compared in the three groups.
  
  
  RESULTS
  There was no significant difference in the three groups in constituent ratio, average IUI times, rate of the natural cycle, rate ofovulation cycle and dropout rate(P>0.05). Similarly, there was also no significant difference in pregnancy outcomes in all groups.Subsequent stratified analysis demonstrated that pregnancy outcomes in subjects of natural cycle and ovulation cycle still showed no significant difference(P>0.05).
  
  
  CONCLUSIONS
  Our study suggested that the effects of three luteal phase supporting strategies on clinical outcomes of IUI were similar.The medication in clinic should be individualized.
authors.affiliation: Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China; #Department of Obstetrics and Gynecology, the General Hospital of the PLA Rocket Force, Beijing 100088, China.
authors.forename: H B
authors.initials: HB
authors.lastname: Chi
authors.forename: L L
authors.initials: LL
authors.lastname: Xin
authors.forename: R
authors.initials: R
authors.lastname: Li
authors.forename: L X
authors.initials: LX
authors.lastname: Chen
authors.forename: N N
authors.initials: NN
authors.lastname: Li
mesh_terms: D000282:Administration, Intravaginal; D004394:Dydrogesterone / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007315:Insemination, Artificial; D008183:Luteal Phase / Q000187:drug effects*; D010060:Ovulation / Q000187:drug effects; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D011374:Progesterone / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D011372:Progestins / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D012189:Retrospective Studies
chemical_list: D011372:Progestins; D011374:Progesterone; D004394:Dydrogesterone