title: Control of memory B cell responses by extrinsic and intrinsic mechanisms.
abstract: Following primary activation, B lymphocytes generate a long-lived memory compartment to harness the organism for future reinfections by the same pathogen species. Only recently the composition and signaling signature of the scarce memory B cell pool could be explored in more detail. This review highlights current concepts of how B cells preserve their antigen experience at the cellular and molecular level.
authors.affiliation: Institute of Cellular and Molecular Immunology, Georg-August-University of Göttingen, Medical Faculty, Humboldtallee 34, 37073 Göttingen, Germany. Electronic address: jwienan@gwdg.de.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Wienands
authors.affiliation: Institute of Cellular and Molecular Immunology, Georg-August-University of Göttingen, Medical Faculty, Humboldtallee 34, 37073 Göttingen, Germany.
authors.forename: Niklas
authors.initials: N
authors.lastname: Engels
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000235:genetics / Q000276:immunology; D016175:B-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D002450:Cell Communication; D018858:Germinal Center / Q000276:immunology / Q000378:metabolism; D006801:Humans; D017578:Immunoglobulin Class Switching / Q000235:genetics / Q000276:immunology; D007156:Immunologic Memory / Q000235:genetics / Q000276:immunology; D056747:Immunomodulation / Q000235:genetics / Q000276:immunology; D008213:Lymphocyte Activation / Q000235:genetics / Q000276:immunology; D010766:Phosphorylation; D011947:Receptors, Antigen, B-Cell / Q000378:metabolism; D017452:Receptors, IgG / Q000378:metabolism; D015398:Signal Transduction; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism; D014443:Tyrosine / Q000378:metabolism
chemical_list: D011947:Receptors, Antigen, B-Cell; D017452:Receptors, IgG; D014443:Tyrosine
keywords: Affinity maturation; B cell antigen receptor; Class-switching; Germinal center; Immunoglobulin tail tyrosine; Memory B lymphocytes