title: Isolation of an imported subgenotype B5 strain of human enterovirus A71 in Chongqing City, China, 2014.
abstract: Enterovirus A71 (EV-A71) is the main pathogen responsible for large outbreaks of hand, foot, and mouth disease (HFMD) in mainland China, and the dominant EV-A71 strains belong to subgenotype C4. To date, only one imported subgenotype B5 of EV-A71 has been reported in Xiamen City Fujian Province, 2009.
  
  
  
  Here, we report on another imported subgenotype B5 of EV-A71 isolated from a HFMD patient in Chongqing City in 2014 (strain CQ2014-86/CQ/CHN/2014, hereafter refer as CQ2014-86). The VP1 coding sequence and the whole genome sequence revealed that strain CQ2014-86 shares the high nucleotide identity with Vietnamese strains isolated in 2011-2013, suggesting that strain CQ2014-86 may have been imported from Vietnam. In the 5'UTR, P2 and P3 regions, recombination events were found between strain CQ2014-86 and other EV-A, such as coxsackievirus A4 (CV-A4), CV-A5, CV-A14 and CV-A16.
  
  
  
  This is the second report on importation of subgenotype B5 of EV-A71 in China, implying that we need to pay more attention to the importation of different subgenotypes of EV-A71.
authors.affiliation: WHO WPRO Regional Polio Reference Laboratory and Key Laboratory of Medical Virology and Viral Disease, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, People's Republic of China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Yang
authors.affiliation: WHO WPRO Regional Polio Reference Laboratory and Key Laboratory of Medical Virology and Viral Disease, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, People's Republic of China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: WHO WPRO Regional Polio Reference Laboratory and Key Laboratory of Medical Virology and Viral Disease, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, People's Republic of China.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Yan
authors.affiliation: WHO WPRO Regional Polio Reference Laboratory and Key Laboratory of Medical Virology and Viral Disease, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, People's Republic of China.
authors.forename: Shuangli
authors.initials: S
authors.lastname: Zhu
authors.affiliation: WHO WPRO Regional Polio Reference Laboratory and Key Laboratory of Medical Virology and Viral Disease, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, People's Republic of China.
authors.forename: Dongyan
authors.initials: D
authors.lastname: Wang
authors.affiliation: WHO WPRO Regional Polio Reference Laboratory and Key Laboratory of Medical Virology and Viral Disease, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, People's Republic of China.
authors.forename: Tianjiao
authors.initials: T
authors.lastname: Ji
authors.affiliation: Chongqing Center for Disease Control and Prevention, Chongqing, 400042, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.affiliation: WHO WPRO Regional Polio Reference Laboratory and Key Laboratory of Medical Virology and Viral Disease, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, People's Republic of China.
authors.forename: Hongqiu
authors.initials: H
authors.lastname: An
authors.affiliation: WHO WPRO Regional Polio Reference Laboratory and Key Laboratory of Medical Virology and Viral Disease, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, People's Republic of China. wenbo_xu1@aliyun.com.
authors.forename: Wenbo
authors.initials: W
authors.lastname: Xu
mesh_terms: D002681:China / Q000453:epidemiology; D004196:Disease Outbreaks; D029821:Enterovirus A, Human / Q000145:classification / Q000235:genetics / Q000302:isolation & purification* / Q000502:physiology; D006232:Hand, Foot and Mouth Disease / Q000453:epidemiology / Q000821:virology*; D006801:Humans; D010802:Phylogeny; D014195:Travel; D014744:Vietnam
keywords: Human enterovirus A71; Importation; Subgenotype B5