title: Marine Sponges as a Drug Treasure.
abstract: Marine sponges have been considered as a drug treasure house with respect to great potential regarding their secondary metabolites. Most of the studies have been conducted on sponge's derived compounds to examine its pharmacological properties. Such compounds proved to have antibacterial, antiviral, antifungal, antimalarial, antitumor, immunosuppressive, and cardiovascular activity. Although, the mode of action of many compounds by which they interfere with human pathogenesis have not been clear till now, in this review not only the capability of the medicinal substances have been examined in vitro and in vivo against serious pathogenic microbes but, the mode of actions of medicinal compounds were explained with diagrammatic illustrations. This knowledge is one of the basic components to be known especially for transforming medicinal molecules to medicines. Sponges produce a different kind of chemical substances with numerous carbon skeletons, which have been found to be the main component interfering with human pathogenesis at different sites. The fact that different diseases have the capability to fight at different sites inside the body can increase the chances to produce targeted medicines.
authors.affiliation: Ocean College, Zhejiang University, Hangzhou 310058, China.
authors.forename: Komal
authors.initials: K
authors.lastname: Anjum
authors.affiliation: Faculty of Pharmacy, Gomal University D.I.Khan, K.P.K. 29050, Pakistan.
authors.forename: Syed Qamar
authors.initials: SQ
authors.lastname: Abbas
authors.affiliation: Ocean College, Zhejiang University, Hangzhou 310058, China.
authors.forename: Sayed Asmat Ali
authors.initials: SA
authors.lastname: Shah
authors.affiliation: Ocean College, Zhejiang University, Hangzhou 310058, China.
authors.forename: Najeeb
authors.initials: N
authors.lastname: Akhter
authors.affiliation: Department of Molecular Biology, University of Heidelberg, Germany.
authors.forename: Sundas
authors.initials: S
authors.lastname: Batool
authors.affiliation: Ocean College, Zhejiang University, Hangzhou 310058, China.
authors.forename: Syed Shams Ul
authors.initials: SS
authors.lastname: Hassan
keywords: Antitumor; Antiviral; Microbes; Pathogenesis; Pharmacokinetics; Sponges