title: Retinal Nerve Fiber Layer and Peripapillary Choroidal Thicknesses in Non-Glaucomatous Unilateral Optic Atrophy Compared with Unilateral Advanced Pseudoexfoliative Glaucoma.
abstract: To investigate retinal nerve fiber layer thickness (RNFL-T) and peripapillary choroidal thickness (PC-T) in non-glaucomatous optic atrophy (OA) patients in comparison with unaffected and control eyes, furthermore, to compare thickness profiles with unilateral pseudoexfoliative advanced glaucoma.
  
  
  
  Thirty-three eyes with OA (Group A), 33 unaffected fellow eyes (Group B), 25 right eyes of 25 control subjects (Group C), and 15 eyes with advanced glaucoma (Group D) were enrolled. RNFL-T was measured in six regions by spectral-domain optical coherence tomography. Enhanced depth imaging optical coherence tomography was obtained to evaluate PC-T in corresponding regions.
  
  
  
  RNFL-T was significantly lower in Group A than in Groups B and C globally and at all peripapillary regions (all p < 0.001). P-CT in Group A was significantly lower globally (p = 0.03) and in three regions (temporal, p = 0.001; temporal-superior, p = 0.01; and nasal-inferior, p = 0.037) versus Group C. However, it was significantly thinner than in Group B in all regions (temporal, p = 0.02; temporal-superior, p = 0.013; nasal-superior, p = 0.044; nasal, p = 0.02; nasal-inferior, p < 0.001; and temporal-inferior, p < 0.001) and globally (p < 0.001). In Group A RNFL-T (thicker superiorly and inferiorly; thinner temporally and nasally) and PC-T (superior > temporal > nasal > inferior) profiles were almost identical to that in unaffected fellow eyes and control eyes. However, Group D showed different patterns with less regional differences in RNFL-T, and the greatest value of PC-T in nasal quadrant.
  
  
  
  Besides retinal nerve fiber layer thinning, non-glaucomatous OA is associated with choroidal thinning. The RNFL-T and PC-T profiles in advanced glaucoma eyes differed from the common patterns seen among OA eyes, unaffected fellow eyes, and control eyes.
authors.affiliation: a Department of Ophthalmology , Gulhane Military Medical School , Ankara , Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Kucukevcilioglu
authors.affiliation: a Department of Ophthalmology , Gulhane Military Medical School , Ankara , Turkey.
authors.forename: Onder
authors.initials: O
authors.lastname: Ayyildiz
authors.affiliation: a Department of Ophthalmology , Gulhane Military Medical School , Ankara , Turkey.
authors.forename: Seckin
authors.initials: S
authors.lastname: Aykas
authors.affiliation: a Department of Ophthalmology , Gulhane Military Medical School , Ankara , Turkey.
authors.forename: Gokcen
authors.initials: G
authors.lastname: Gokce
authors.affiliation: b Department of Ophthalmology , Tatvan Military Hospital , Bitlis , Turkey.
authors.forename: Mehmet Talay
authors.initials: MT
authors.lastname: Koylu
authors.affiliation: c Department of Ophthalmology , Van Military Hospital , Van , Turkey.
authors.forename: Cem
authors.initials: C
authors.lastname: Ozgonul
authors.affiliation: a Department of Ophthalmology , Gulhane Military Medical School , Ankara , Turkey.
authors.forename: Gokhan
authors.initials: G
authors.lastname: Ozge
authors.affiliation: a Department of Ophthalmology , Gulhane Military Medical School , Ankara , Turkey.
authors.forename: Tarkan
authors.initials: T
authors.lastname: Mumcuoglu
authors.affiliation: d Department of Ophthalmology , Kirikkale University , Kirikkale , Turkey.
authors.forename: Erhan
authors.initials: E
authors.lastname: Yumusak
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002829:Choroid / Q000473:pathology*; D017889:Exfoliation Syndrome / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology; D009896:Optic Atrophy / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D009898:Optic Disk / Q000473:pathology*; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012720:Severity of Illness Index; D041623:Tomography, Optical Coherence / Q000379:methods; D014792:Visual Acuity; D014794:Visual Fields
keywords: Advanced glaucoma; optic atrophy; peripapillary choroid; retinal nerve fiber layer; thickness profile