title: Relationship between the efficacy of oral antidiabetic drugs and clinical features in type 2 diabetic patients (JDDM38).
abstract: OBJECTIVE
  We carried out an observational cohort study to examine the relationship between the efficacy of oral antidiabetic drugs and clinical features in type 2 diabetics.
  
  
  METHODS
  We analyzed the CoDiC(®) database of the Japan Diabetes Data Management Study Group across 67 institutions in Japan. In a total of 3,698 drug-naïve patients who were initiated with metformin, dipeptidyl peptidase-4 inhibitor (DPP-4i) or sulfonylurea (SU) from 2007 to 2012, we evaluated body mass index (BMI) and hemoglobin A1c (HbA1c). The patients were stratified according to their clinical features, and matched using a propensity score to adjust for baseline factors.
  
  
  RESULTS
  HbA1c was reduced with all drugs, with the largest effect elicited by DPP-4i and the smallest by SU (P = 0.00). HbA1c increased with SU after 6 months in the patients stratified by an age-of-onset of <50 years (P = 0.00). BMI increased with SU in the patients stratified by a BMI of <25 (P = 0.00), and decreased with metformin in the patients with a BMI >25 (P = 0.00). The reduction in HbA1c was larger in patients with HbA1c of ≥8%, compared with that in patients with HbA1c of <8% (P = 0.00). HbA1c during the study period was higher in patients who were added to or swapped with other drug(s), than in patients continued on the original drug (P = 0.00).
  
  
  CONCLUSIONS
  The effect on bodyweight and glycemic control differed among metformin, DPP-4i and SU, and the difference was associated with clinical features.
authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.affiliation: Clinical Research Center Graduate School of Medicine Chiba University Chiba Japan.
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
authors.forename: Kazumasa
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.lastname: Lee
authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
authors.forename: Akira
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authors.lastname: Tsuruoka
authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
authors.forename: Naoki
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authors.lastname: Manda
authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
authors.forename: Kiyokazu
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.lastname: Takeda
authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.lastname: Taguchi
authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.lastname: Yamazaki
authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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authors.lastname: Wada
authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
authors.forename: Noriharu
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
authors.forename: Kuniko
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authors.affiliation: Diabetes Center Chiba Central Medical Center Chiba University Chiba Japan.
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mesh_terms: D000284:Administration, Oral; D000368:Aged; D015992:Body Mass Index; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000378:metabolism; D054873:Dipeptidyl-Peptidase IV Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008687:Metformin / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D057216:Propensity Score; D013453:Sulfonylurea Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D054873:Dipeptidyl-Peptidase IV Inhibitors; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D008687:Metformin; D013453:Sulfonylurea Compounds; C517652:hemoglobin A1c protein, human
keywords: Oral antidiabetic drug; Propensity score‐matched cohort study; Type 2 diabetes mellitus