title: Association between N-terminal pro-brain natriuretic peptide and adiponectin in healthy Japanese men.
abstract: BACKGROUND
  The natriuretic peptides, brain natriuretic peptide (BNP) and N-terminal-proBNP (NT-proBNP), are cardiac-derived hormones and can serve as biomarkers for ventricular dysfunction. BNP has cardio-protective effects and is known as a regulator of metabolism. In the present study, to evaluate the relationship between natriuretic peptides and metabolic disorders, we focused on the association between NT-proBNP and metabolic syndrome-related molecule adiponectin (APN).
  
  
  METHODS
  Forty-five apparently healthy men who underwent health examination at the Osaka University Health Care Center were enrolled for this study. Physical and biochemical parameters including serum APN and NT-proBNP concentrations were obtained from all the subjects.
  
  
  RESULTS
  The serum concentrations of NT-proBNP negatively correlated with metabolic disorder parameters, body mass index (BMI), waist circumferences, and fasting plasma glucose levels, but positively correlated with APN, suggesting that similar to APN, NT-proBNP is associated with metabolic disorders. Furthermore, increased serum concentrations of APN were found to be accompanied by increased serum concentrations of NT-proBNP and decreased BMI and mean intima-media thickness.
  
  
  CONCLUSIONS
  The serum concentrations of NT-proBNP are associated with APN concentrations and metabolic disorder parameters in healthy subjects.
authors.affiliation: Health Care Center, Osaka University, Toyonaka, Osaka, Japan.
authors.forename: Kaori
authors.initials: K
authors.lastname: Nakanishi
authors.affiliation: Health Care Center, Osaka University, Toyonaka, Osaka, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Nishida
authors.affiliation: Health Care Center, Osaka University, Toyonaka, Osaka, Japan.
authors.forename: Ryohei
authors.initials: R
authors.lastname: Yamamoto
authors.affiliation: Health Care Center, Osaka University, Toyonaka, Osaka, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Koseki
authors.affiliation: Health Care Center, Osaka University, Toyonaka, Osaka, Japan.
authors.forename: Toshiki
authors.initials: T
authors.lastname: Moriyama
authors.affiliation: Health Care Center, Osaka University, Toyonaka, Osaka, Japan. Electronic address: takihara@wellness.hss.osaka-u.ac.jp.
authors.forename: Keiko
authors.initials: K
authors.lastname: Yamauchi-Takihara
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D044466:Asian People; D015992:Body Mass Index; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000175:diagnosis; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D017539:Tunica Intima; D017540:Tunica Media
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: Adiponectin; Intima-media thickness; Metabolic disorder; Natriuretic peptides