title: Three-day regimen of oseltamivir for postexposure prophylaxis of influenza in wards.
abstract: Inpatients who had been in close contact with patients with influenza were given oseltamivir [75mg capsules once daily for adults or 2mg/kg (maximum of 75mg) once daily for children] for three days as postexposure prophylaxis (PEP). The index patients with influenza were prescribed a neuraminidase inhibitor and were discharged immediately or transferred to isolation rooms. The protective efficacy of oseltamivir for three days was 93% overall [95% confidence interval (CI) 53-99%; P=0.023] and 94% for influenza A (95% CI 61-99%; P=0.017), which is comparable to that of seven- to 10-day regimens of oseltamivir as PEP.
authors.affiliation: Infection Control Team, Hokkaido University Hospital, Sapporo, Japan. Electronic address: nishigur@med.hokudai.ac.jp.
authors.forename: N
authors.initials: N
authors.lastname: Ishiguro
authors.affiliation: Infection Control Team, Hokkaido University Hospital, Sapporo, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Oyamada
authors.affiliation: Division of Hospital Safety Management, Hokkaido University Hospital, Sapporo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nasuhara
authors.affiliation: Infection Control Team, Hokkaido University Hospital, Sapporo, Japan; Division of Pharmacy, Hokkaido University Hospital, Sapporo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yamada
authors.affiliation: Infection Control Team, Hokkaido University Hospital, Sapporo, Japan; Division of Pharmacy, Hokkaido University Hospital, Sapporo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Miyamoto
authors.affiliation: Infection Control Team, Hokkaido University Hospital, Sapporo, Japan; Division of Pharmacy, Hokkaido University Hospital, Sapporo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Imai
authors.affiliation: Infection Control Team, Hokkaido University Hospital, Sapporo, Japan; Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital, Sapporo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Akizawa
authors.affiliation: Infection Control Team, Hokkaido University Hospital, Sapporo, Japan; Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital, Sapporo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Fukumoto
authors.affiliation: Infection Control Team, Hokkaido University Hospital, Sapporo, Japan; Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital, Sapporo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Iwasaki
authors.affiliation: Clinical Research and Medical Innovation Centre, Hokkaido University Hospital, Sapporo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Iijima
authors.affiliation: Clinical Research and Medical Innovation Centre, Hokkaido University Hospital, Sapporo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ono
mesh_terms: D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000008:administration & dosage*; D018890:Chemoprevention / Q000379:methods*; D005260:Female; D006801:Humans; D007251:Influenza, Human / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D053139:Oseltamivir / Q000008:administration & dosage*; D056990:Post-Exposure Prophylaxis / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D053139:Oseltamivir
keywords: Influenza; Oseltamivir; Postexposure prophylaxis