title: Serum anti-Müllerian hormone levels in euthyroid adolescent girls with Hashimoto's thyroiditis: relationship to antioxidant status.
abstract: OBJECTIVE
  Free radical-mediated oxidative stress has been implicated in the etiopathogenesis of Hashimoto's thyroiditis (HT), which is the most common thyroid disorder in adolescents. HT requires lifelong thyroid surveillance, particularly in women of childbearing age to avoid adverse effects on reproductive function. The aims of this study were to investigate serum concentrations of anti-Müllerian hormone (AMH), a marker of ovarian reserve, in euthyroid adolescent girls with newly diagnosed HT and explore the relationships between AMH levels and biomarkers of antioxidant status.
  
  
  METHODS
  We recruited 57 non-obese (body mass index [BMI] Z-score<2) adolescent girls with newly diagnosed HT and 50 age- and BMI-matched healthy controls for this case-control study. All participants were euthyroid. Hormonal and metabolic parameters, serum levels of AMH, and antioxidant status [paraoxonase (PON) and arylesterase (ARE) activities] were assessed.
  
  
  RESULTS
  Serum AMH levels were significantly higher and serum PON and ARE activities were significantly lower in adolescents with HT than in the controls (p<0.001 for all). No significant associations were detected between the AMH level and any of the clinical or biochemical parameters in the control group. Serum AMH levels were negatively correlated with PON (r=-0.435, p=0.001) and ARE (r=-0.422, p=0.001) activities in adolescents with HT.
  
  
  CONCLUSIONS
  The AMH level was significantly higher while the PON and ARE activities were significantly lower in euthyroid adolescent girls with newly diagnosed HT.
authors.affiliation: Department of Obstetrics and Gynecology, Antalya Training and Research Hospital, Antalya, Turkey. Electronic address: dronurerol@hotmail.com.
authors.forename: Onur
authors.initials: O
authors.lastname: Erol
authors.affiliation: Department of Pediatric Endocrinology, Antalya Training and Research Hospital, Antalya, Turkey.
authors.forename: Mesut
authors.initials: M
authors.lastname: Parlak
authors.affiliation: Department of Biochemistry, Antalya Training and Research Hospital, Antalya, Turkey.
authors.forename: Hamit Yaşar
authors.initials: HY
authors.lastname: Ellidağ
authors.affiliation: Department of Radiology, Antalya Training and Research Hospital, Antalya, Turkey.
authors.forename: Ayşe Eda
authors.initials: AE
authors.lastname: Parlak
authors.affiliation: Department of Obstetrics and Gynecology, Antalya Training and Research Hospital, Antalya, Turkey.
authors.forename: Aysel Uysal
authors.initials: AU
authors.lastname: Derbent
authors.affiliation: Department of Biochemistry, Antalya Training and Research Hospital, Antalya, Turkey.
authors.forename: Esin
authors.initials: E
authors.lastname: Eren
authors.affiliation: Department of Biochemistry, Antalya Training and Research Hospital, Antalya, Turkey.
authors.forename: Necat
authors.initials: N
authors.lastname: Yılmaz
mesh_terms: D000293:Adolescent; D054304:Anti-Mullerian Hormone / Q000097:blood*; D043303:Aryldialkylphosphatase / Q000097:blood; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002265:Carboxylic Ester Hydrolases / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D003430:Cross-Sectional Studies; D015536:Down-Regulation; D005260:Female; D050031:Hashimoto Disease / Q000097:blood* / Q000201:enzymology / Q000503:physiopathology; D006784:Hospitals, Teaching; D006801:Humans; D065851:Ovarian Reserve; D018384:Oxidative Stress; D011446:Prospective Studies; D012720:Severity of Illness Index; D014421:Turkey; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D054304:Anti-Mullerian Hormone; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase
keywords: Adolescent; Anti-Müllerian hormone; Antioxidant status; Hashimoto's thyroiditis; Ovarian reserve