title: SLC6A3 rs28363170 and rs3836790 variants in Han Chinese patients with sporadic Parkinson's disease.
abstract: Parkinson's disease (PD; OMIM 168600) is the second most common neurodegenerative disorder characterized by the loss of dopamine-producing neurons in the substantia nigra and other brainstem nuclei. Recently, two variants (rs28363170 and rs3836790) in the solute carrier family 6 member 3 gene (SLC6A3) were identified to be significantly associated with PD patients in French population. The purpose of our study was to explore whether these two variants are associated with sporadic PD in Han Chinese population. We designed a case-control comparison study in 521 Han Chinese patients with sporadic PD and 502 age, gender and ethnicity matched normal controls from Mainland China. There is no statistically significant difference in either genotypic or allelic distribution between disease group and normal controls in our cohort for the two variants (all P>0.05). In addition, we did not identify any related haplotype that would either increase the risk for PD or play a protective role against PD. Our data suggest that variants rs28363170 and rs3836790 are not associated with sporadic PD in Han Chinese population.
authors.affiliation: Center for Experimental Medicine, The Third Xiangya Hospital, Central South University, Changsha, China; Department of Neurology, The Third Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Lu
authors.affiliation: Department of Neurology, The Third Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Song
authors.affiliation: Center for Experimental Medicine, The Third Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Xiong
authors.initials: X
authors.lastname: Deng
authors.affiliation: Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xiong
authors.affiliation: Center for Experimental Medicine, The Third Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Xu
authors.affiliation: Center for Experimental Medicine, The Third Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Zhenmei
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Center for Experimental Medicine, The Third Xiangya Hospital, Central South University, Changsha, China. Electronic address: hwlv2226@163.com.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Lu
authors.affiliation: Center for Experimental Medicine, The Third Xiangya Hospital, Central South University, Changsha, China; Department of Neurology, The Third Xiangya Hospital, Central South University, Changsha, China. Electronic address: hdeng008@yahoo.com.
authors.forename: Hao
authors.initials: H
authors.lastname: Deng
mesh_terms: D000368:Aged; D044466:Asian People; D016022:Case-Control Studies; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; C493214:SLC6A3 protein, human
keywords: Han Chinese; Rs28363170; Rs3836790; Sporadic Parkinson’s disease; The SLC6A3 gene