title: Melonoside A: An ω-Glycosylated Fatty Acid Amide from the Far Eastern Marine Sponge Melonanchora kobjakovae.
abstract: Melonoside A (1), the first representative of a new class of ω-glycosylated fatty acid amides, was isolated from the Far Eastern marine sponge Melonanchora kobjakovae. The structure of 1, including absolute configuration, was established using detailed analysis of 1D and 2D NMR, CD, and mass spectra as well as chemical transformations. Compound 1 induces autophagy of human cisplatin-resistant germinal tumor cells NCCIT-R.
authors.affiliation: G.B. Elyakov Pacific Institute of Bioorganic Chemistry , Far East Branch of the Russian Academy of Sciences, Vladivostoku 690022, Russia.
authors.forename: Alla G
authors.initials: AG
authors.lastname: Guzii
authors.affiliation: G.B. Elyakov Pacific Institute of Bioorganic Chemistry , Far East Branch of the Russian Academy of Sciences, Vladivostoku 690022, Russia.
authors.forename: Tatyana N
authors.initials: TN
authors.lastname: Makarieva
authors.affiliation: G.B. Elyakov Pacific Institute of Bioorganic Chemistry , Far East Branch of the Russian Academy of Sciences, Vladivostoku 690022, Russia.
authors.forename: Vladimir A
authors.initials: VA
authors.lastname: Denisenko
authors.affiliation: G.B. Elyakov Pacific Institute of Bioorganic Chemistry , Far East Branch of the Russian Academy of Sciences, Vladivostoku 690022, Russia.
authors.forename: Pavel S
authors.initials: PS
authors.lastname: Dmitrenok
authors.affiliation: G.B. Elyakov Pacific Institute of Bioorganic Chemistry , Far East Branch of the Russian Academy of Sciences, Vladivostoku 690022, Russia.
authors.forename: Aleksandra S
authors.initials: AS
authors.lastname: Kuzmich
authors.affiliation: G.B. Elyakov Pacific Institute of Bioorganic Chemistry , Far East Branch of the Russian Academy of Sciences, Vladivostoku 690022, Russia.|Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumorzentrum, University Medical Center Hamburg-Eppendorf , 20246 Hamburg, Germany.
authors.forename: Sergey A
authors.initials: SA
authors.lastname: Dyshlovoy
authors.affiliation: Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumorzentrum, University Medical Center Hamburg-Eppendorf , 20246 Hamburg, Germany.
authors.forename: Gunhild
authors.initials: G
authors.lastname: von Amsberg
authors.affiliation: G.B. Elyakov Pacific Institute of Bioorganic Chemistry , Far East Branch of the Russian Academy of Sciences, Vladivostoku 690022, Russia.
authors.forename: Vladimir B
authors.initials: VB
authors.lastname: Krasokhin
authors.affiliation: G.B. Elyakov Pacific Institute of Bioorganic Chemistry , Far East Branch of the Russian Academy of Sciences, Vladivostoku 690022, Russia.
authors.forename: Valentin A
authors.initials: VA
authors.lastname: Stonik
mesh_terms: D000577:Amides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001343:Autophagy / Q000187:drug effects; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005227:Fatty Acids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005965:Glucuronates / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*
chemical_list: D000577:Amides; D000970:Antineoplastic Agents; D005227:Fatty Acids; D005965:Glucuronates