title: Zebiriosides A-L, oleanane saponins from the roots of Dendrobangia boliviana.
abstract: Twelve oleanane saponins, zebiriosides A-L, were isolated from the roots of Dendrobangia boliviana Rusby, together with two known saponins, talunùmoside I and 3-O-β-d-glucuronopyranosyl serjanic acid. These saponins are glycosides of serjanic or phytolaccinic acid. Their structures were established on two basis: first, their spectral data, mainly HR-TOFESIMS, 1D-NMR ((1)H, (13)C, DEPT) and 2D-NMR ((1)H(1)H COSY, TOCSY, HSQC, HMBC, and ROESY), and second by comparison with literature data. These compounds were evaluated for their cytotoxic, antileishmanial and hemolytic activities. No antileishmanial or hemolytic activities were revealed, however zebirioside C and zebirioside I showed cytotoxicity against fibroblasts with IC50 of 6.4 and 5.6 μM, respectively.
authors.affiliation: Institut de Chimie Moléculaire de Reims UMR 7312 CNRS, Université de Reims Champagne-Ardenne, BP 1039, 51687 REIMS Cedex, France. Electronic address: lila_z@hotmail.com.
authors.forename: Ilhem
authors.initials: I
authors.lastname: Zebiri
authors.affiliation: UMR 152 Pharma Dev, Université de Toulouse, IRD, UPS, France.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Haddad
authors.affiliation: Unité Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), UMR CNRS 7369, Université de Reims Champagne-Ardenne, BP 1039, 51687 REIMS Cedex, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Duca
authors.affiliation: Institut de Chimie Moléculaire de Reims UMR 7312 CNRS, Université de Reims Champagne-Ardenne, BP 1039, 51687 REIMS Cedex, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Harakat
authors.affiliation: Instituto de Investigación de la Amazonía Peruana (IIAP), Iquitos-Quistococha, Peru.
authors.forename: Billy
authors.initials: B
authors.lastname: Cabanillas
authors.affiliation: CNRS, LCC (Laboratoire de Chimie de Coordination) UPR8241, 205 route de Narbonne, BP 44099, F-31077 Toulouse Cedex 4, France; Université de Toulouse, UPS, INPT, F-31077 Toulouse Cedex 4, France.
authors.forename: Lucie
authors.initials: L
authors.lastname: Paloque
authors.affiliation: Givandan ACI, Soliance, Route de Bazancourt, Pomacle, France.
authors.forename: Amandine
authors.initials: A
authors.lastname: Scandolera
authors.affiliation: UMR 152 Pharma Dev, Université de Toulouse, IRD, UPS, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Sauvain
authors.affiliation: Instituto de Investigación de la Amazonía Peruana (IIAP), Iquitos-Quistococha, Peru.
authors.forename: Elsa
authors.initials: E
authors.lastname: Rengifo
authors.affiliation: Institut de Chimie Moléculaire de Reims UMR 7312 CNRS, Université de Reims Champagne-Ardenne, BP 1039, 51687 REIMS Cedex, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Voutquenne-Nazabadioko
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005347:Fibroblasts / Q000187:drug effects; D007891:Leishmania / Q000187:drug effects; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003603:Cytotoxins; D012503:Saponins; D014315:Triterpenes; C413246:oleanane; C000614418:zebirioside C; C000614419:zebirioside I; D009828:Oleanolic Acid
keywords: Cardiopteridaceae; Cytotoxic activity; Dendrobangia boliviana; Triterpenoid saponins