title: Evaluation of shared genetic susceptibility loci between autoimmune diseases and schizophrenia based on genome-wide association studies.
abstract: BACKGROUND
  Epidemiological studies have documented higher than expected comorbidity (or, in some cases, inverse comorbidity) between schizophrenia and several autoimmune disorders. It remains unknown whether this comorbidity reflects shared genetic susceptibility loci.
  
  
  OBJECTIVE
  The present study aimed to investigate whether verified genome wide significant variants of autoimmune disorders confer risk of schizophrenia, which could suggest a common genetic basis.
  
  
  METHODS
  Seven hundred and fourteen genome wide significant risk variants of 25 autoimmune disorders were extracted from the NHGRI GWAS catalogue and examined for association to schizophrenia in the Psychiatric Genomics Consortium schizophrenia GWAS samples (36,989 cases and 113,075 controls).
  
  
  RESULTS
  Two independent loci at 4q24 and 6p21.32-33 originally identified from GWAS of autoimmune diseases were found genome wide associated with schizophrenia (1.7 × 10-8≥p ≥ 4.0 × 10-21). While these observations confirm the existence of shared genetic susceptibility loci between schizophrenia and autoimmune diseases, the findings did not show a significant enrichment.
  
  
  CONCLUSIONS
  The findings do not support a genetic overlap in common SNPs between autoimmune diseases and schizophrenia that in part could explain the observed comorbidity from epidemiological studies.
authors.affiliation: a Institute of Biological Psychiatry, Mental Health Centre Sct. Hans, Mental Health Services Copenhagen , Denmark.|b iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research , Denmark.
authors.forename: Louise K
authors.initials: LK
authors.lastname: Hoeffding
authors.affiliation: a Institute of Biological Psychiatry, Mental Health Centre Sct. Hans, Mental Health Services Copenhagen , Denmark.|b iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research , Denmark.
authors.forename: Anders
authors.initials: A
authors.lastname: Rosengren
authors.affiliation: a Institute of Biological Psychiatry, Mental Health Centre Sct. Hans, Mental Health Services Copenhagen , Denmark.
authors.forename: Johan H
authors.initials: JH
authors.lastname: Thygesen
authors.affiliation: a Institute of Biological Psychiatry, Mental Health Centre Sct. Hans, Mental Health Services Copenhagen , Denmark.|b iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research , Denmark.
authors.forename: Henriette
authors.initials: H
authors.lastname: Schmock
authors.affiliation: a Institute of Biological Psychiatry, Mental Health Centre Sct. Hans, Mental Health Services Copenhagen , Denmark.|b iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research , Denmark.|c Department of Clinical Medicine , University of Copenhagen , Denmark.
authors.forename: Thomas
authors.initials: T
authors.lastname: Werge
authors.affiliation: a Institute of Biological Psychiatry, Mental Health Centre Sct. Hans, Mental Health Services Copenhagen , Denmark.|b iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research , Denmark.
authors.forename: Thomas
authors.initials: T
authors.lastname: Hansen
mesh_terms: D001327:Autoimmune Diseases / Q000453:epidemiology / Q000235:genetics*; D015897:Comorbidity; D005260:Female; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000453:epidemiology / Q000235:genetics*
keywords: GWAS; autoimmune diseases; comorbidity; schizophrenia