title: A Case of Metastatic Urachal Cancer Including a Neuroendocrine Component Treated with Gemcitabine, Cisplatin and Paclitaxel Combination Chemotherapy.
abstract: The present case report describes a case of recurrent and advanced urachal carcinoma including neuroendocrine features with iliac bone metastasis after partial cystectomy and adjuvant chemotherapy consisting of irinotecan and cisplatin in a 32-year-old man. He received gemcitabine/cisplatin/ paclitaxel (GCP) combination chemotherapy, consisting of gemcitabin (1,000mg/m2) on day 1, 8, cisplatin (70mg/m2) on day 1, and paclitaxel (80mg/m2) on day 1 and 8. After three cycles of chemotherapy, PET-CT showed complete regression of the disease. So the patient underwent total cystourethrectomy, and histological examination showed an almost complete pathological response. External beam radiation therapy was also given to the ileac bone metastasis regions. However, PET-CT taken 17 months after the external beam radiation showed multiple lung metastases. He received GCP chemotherapy again, which resulted in a complete response again after three cycles of chemotherapy. This is the first report on GCP chemotherapy used not only as a salvage chemotherapy but also as a rechallenge regimen for metastatic urachal cancer including a neuroendocrine component.
authors.affiliation: Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.pjcr7j4j@cc.okayama-u.ac.jp.
authors.forename: Shin
authors.initials: S
authors.lastname: Ebara
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Katsumi
authors.initials: K
authors.lastname: Sasaki
authors.forename: Motoo
authors.initials: M
authors.lastname: Araki
authors.forename: Morito
authors.initials: M
authors.lastname: Sugimoto
authors.forename: Koichiro
authors.initials: K
authors.lastname: Wada
authors.forename: Kei
authors.initials: K
authors.lastname: Fujio
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takamoto
authors.forename: Toyohiko
authors.initials: T
authors.lastname: Watanabe
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yanai
authors.forename: Yasutomo
authors.initials: Y
authors.lastname: Nasu