title: Positive and negative functions of B lymphocytes in tumors.
abstract: Accumulating evidence indicated that B lymphocytes exerted complex functions in tumor immunity. On the one hand, B lymphocytes can inhibit tumor development through antibody generation, antigen presentation, tumor tissue interaction, and direct killing. On the other hand, B lymphocytes have tumor-promoting functions. A typical type of B lymphocytes, termed regulatory B cells, is confirmed to attenuate immune response in a tumor environment. In this paper, we summarize the current understanding of B-cell functions in tumor immunology, which may shed light on potential therapeutic strategies against cancer.
authors.affiliation: Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.|National Clinical Research Center of Cancer, Tianjin, China.|Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Shen
authors.affiliation: Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.|National Clinical Research Center of Cancer, Tianjin, China.|Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Sun
authors.affiliation: Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.|National Clinical Research Center of Cancer, Tianjin, China.|Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.|National Clinical Research Center of Cancer, Tianjin, China.|Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Pan
authors.affiliation: Department of Biotherapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.|National Clinical Research Center of Cancer, Tianjin, China.|Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, China.
authors.forename: Xiubao
authors.initials: X
authors.lastname: Ren
mesh_terms: D000818:Animals; D000917:Antibody Formation; D000938:Antigen-Presenting Cells / Q000502:physiology; D001402:B-Lymphocytes / Q000502:physiology*; D060151:B-Lymphocytes, Regulatory / Q000502:physiology; D016207:Cytokines / Q000096:biosynthesis; D006801:Humans; D008211:Lymphocyte Cooperation; D009369:Neoplasms / Q000276:immunology*
chemical_list: D016207:Cytokines
keywords: B lymphocytes; regulatory B cells; tumor; tumor immunotherapy; tumor-infiltrating B cells