title: A Follow-up Study on BMI-SDS and Insulin Resistance in Overweight and Obese Children at Risk for Type 2 Diabetes Mellitus.
abstract: Objectives. To evaluate body mass index standard deviation score (BMI-SDS), insulin sensitivity, and progression to type 2 diabetes mellitus (T2DM) in children at risk for T2DM approximately 3 years after being diagnosed with overweight/obesity and insulin resistance (measured by Homeostasis Model Assessment of Insulin Resistance [HOMA-IR]). Methods. Out of 86 invited children, 44 (mean age 15.4 ± 3.6 years) participated. Medical history, physical examination, and laboratory workup were performed. Results. While the mean BMI-SDS significantly increased from 2.9 to 3.4, the mean HOMA-IR significantly decreased from 5.5 to 4.6 (baseline vs follow-up visit). Change in HOMA-IR was only due to a decrease in mean fasting plasma insulin (24.1 vs 21.1, P = .073). Conclusions. Although increase in BMI-SDS in these children is worrisome, the American Diabetes Association recommended screening interval of 3 years for children at risk for T2DM is not too long based on the fact that none of our study participants developed T2DM.
authors.affiliation: Utrecht University, Utrecht, Netherlands.
authors.forename: Soulmaz
authors.initials: S
authors.lastname: Fazeli Farsani
authors.affiliation: St Antonius Hospital, Nieuwegein, Netherlands.
authors.forename: Marloes P
authors.initials: MP
authors.lastname: van der Aa
authors.affiliation: St Antonius Hospital, Nieuwegein, Netherlands; Leiden University, Leiden, Netherlands.
authors.forename: Catherijne A J
authors.initials: CA
authors.lastname: Knibbe
authors.affiliation: Utrecht University, Utrecht, Netherlands.
authors.forename: Anthonius
authors.initials: A
authors.lastname: de Boer
authors.affiliation: St Antonius Hospital, Nieuwegein, Netherlands.
authors.forename: Marja M J
authors.initials: MM
authors.lastname: van der Vorst
keywords: children; insulin resistance; screening; type 2 diabetes mellitus