title: Association of lincRNA-p21 Haplotype with Coronary Artery Disease in a Chinese Han Population.
abstract: lincRNA-p21 plays an important role in the pathogenesis and progression of coronary artery disease (CAD). To date, the biological significance of polymorphisms in lincRNA-p21 on CAD risk remains unknown. Here we aimed to evaluate the influence of lincRNA-p21 polymorphisms on individual susceptibility to CAD. Genotyping of four tagSNPs (rs9380586, rs4713998, rs6930083, and rs6931097) within lincRNA-p21 gene was performed in 615 CAD and 655 controls. The haplotype analysis showed that the haplotype G-A-A-G (rs9380586-rs4713998-rs6930083-rs6931097) was statistically significantly associated with the reduced risk for CAD (OR = 0.78, P = 0.023). Stratified analysis revealed that G-A-A-G haplotype was at a significantly lower risk for myocardial infarction (MI) (OR = 0.68, P = 0.010). We also found that haplotype G-A-A-G had a more pronounced decreased risk for premature CAD or MI subjects (OR = 0.67, P = 0.017 for premature CAD, and OR = 0.65, P = 0.041 for premature MI, resp.). Our data provide the first evidence that the G-A-A-G haplotype of lincRNA-p21 is associated with decreased risk of CAD and MI, particularly among premature CAD/MI in the Chinese Han population. Further studies with more subjects and in diverse ethnic populations are warranted to clarify the general validity of our findings.
authors.affiliation: Institute of Aging Research, Guangdong Medical University, Dongguan 523808, China; Institute of Biochemistry & Molecular Biology, Guangdong Medical University, Zhanjiang 524023, China; Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical University, Dongguan 523808, China.
authors.forename: Sai-Sai
authors.initials: SS
authors.lastname: Tang
authors.affiliation: Institute of Aging Research, Guangdong Medical University, Dongguan 523808, China; Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical University, Dongguan 523808, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Cheng
authors.affiliation: Institute of Aging Research, Guangdong Medical University, Dongguan 523808, China; Institute of Biochemistry & Molecular Biology, Guangdong Medical University, Zhanjiang 524023, China; Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical University, Dongguan 523808, China.
authors.forename: Meng-Yun
authors.initials: MY
authors.lastname: Cai
authors.affiliation: Department of Cardiovascular Disease, The First People's Hospital of Foshan, Foshan 528000, China.
authors.forename: Xi-Li
authors.initials: XL
authors.lastname: Yang
authors.affiliation: Institute of Aging Research, Guangdong Medical University, Dongguan 523808, China; Institute of Biochemistry & Molecular Biology, Guangdong Medical University, Zhanjiang 524023, China; Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical University, Dongguan 523808, China.
authors.forename: Xin-Guang
authors.initials: XG
authors.lastname: Liu
authors.affiliation: Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical University, Dongguan 523808, China; Institute of Laboratory Medicine, Guangdong Medical University, Dongguan 523808, China.
authors.forename: Bi-Ying
authors.identifier: 0000-0003-2817-2683
authors.initials: BY
authors.lastname: Zheng
authors.affiliation: Institute of Aging Research, Guangdong Medical University, Dongguan 523808, China; Institute of Biochemistry & Molecular Biology, Guangdong Medical University, Zhanjiang 524023, China; Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical University, Dongguan 523808, China.
authors.forename: Xing-Dong
authors.identifier: 0000-0003-4956-0917
authors.initials: XD
authors.lastname: Xiong
mesh_terms: D015415:Biomarkers / Q000378:metabolism*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000235:genetics*; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D062085:RNA, Long Noncoding / Q000235:genetics*; D060888:Real-Time Polymerase Chain Reaction
chemical_list: D015415:Biomarkers; D050759:Cyclin-Dependent Kinase Inhibitor p21; D062085:RNA, Long Noncoding