title: Serum myeloperoxidase (MPO) activity, oxidative and antioxidative parameters in operating room personnel.
abstract: To investigate the effects of occupational exposure to anaesthetic gases on myeloperoxidase activity, oxidative and antioxidative parameters in operating room personnel.
  
  
  
  The cross-sectional study was conducted at Yuzuncu Yil University, Van, Turkey, in May 2011, and comprised equal number of operating room and non-operating room personnel. Serum myeloperoxidase activity, sulfhydryl group levels, lipid hydroperoxide levels and catalase activity were determined. SPSS 11 was used for data analysis.
  
  
  
  There were 64 subjects; 32(50%) each in the two groups. Myeloperoxidase activity and lipid hydroperoxide levels were significantly higher in operating room personnel than in the non-operating room personnel (p<0.001; p<0.001), while catalase activity and sulfhydryl group levels were significantly lower (p<0.009; p<0.003). Catalase activity negatively correlated with lipid hydroperoxide levels in operating room personnel (r=-0.293; p=0.018). Myeloperoxidase activity negatively correlated with sulfhydryl group levels in operating room personnel (r=-0.267; p=0.031).
  
  
  
  Operating room personnel exhibited higher oxidative stress, which may be due to the oxidative effect of anaesthetic gases.
authors.affiliation: Department of Anaesthesiology and Reanimation, Turkey.
authors.forename: Muhammed Bilal
authors.initials: MB
authors.lastname: Cegin
authors.affiliation: Department of Internal Medicine, Yuzuncu Yil University, Medical Faculty, Van, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Aslan
authors.affiliation: Department of Anaesthesiology and Reanimation, Turkey.
authors.forename: Ugur
authors.initials: U
authors.lastname: Goktas
authors.affiliation: Department of Anaesthesiology and Reanimation, Katip Celebi University, Medical Faculty, Izmir, Turkey.
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Isik
authors.affiliation: Department of Anaesthesiology and Reanimation, Turkey.
authors.forename: Lokman
authors.initials: L
authors.lastname: Soyoral
authors.affiliation: Department of Clinical Biochemistry, Turkey.
authors.forename: Nurten
authors.initials: N
authors.lastname: Aksoy
authors.affiliation: PhD Student, Harran University, Medical Faculty, Sanliurfa, Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Taskin
authors.affiliation: Department of Anaesthesiology and Reanimation, Gazi University, Medical Faculty, Ankara, Turkey.
authors.forename: Ismail
authors.initials: I
authors.lastname: Kati
mesh_terms: D003430:Cross-Sectional Studies; D006801:Humans; D009873:Operating Rooms; D018384:Oxidative Stress; D009195:Peroxidase / Q000378:metabolism*; D010564:Personnel, Hospital; D014421:Turkey
chemical_list: D009195:Peroxidase
keywords: Anaesthetic gases, Myeloperoxidase activity, Occupational exposure, Oxidative stress, Sulfhydryl groups.