title: Co-suppression of vitamin C composite nano-drug carrier and its drug delivery to nidus in tumor cells.
abstract: This study aimed to discuss the co-suppression of vitamin C-contained composite nano-drug carrier and its drug delivery to nidus in tumor cells. Amphiphilic polymers PLA-block-PAAA and block polymer PLA-PEG4000-Maleimide, PLA-block-PAAA and PLA-PEG4000-Maleimide composite nano-micelles were prepared, and, PLA-block-PAAA polymer-coated Nile red nano-micelle, PLA-block-PAA and PLA-PEG4000-Maleimide composite nano-micelles as well as paclitaxel-carrying composite nano-micelle in different molar ratios were given stability tests. Lastly, PLA-block-PAAA and PLA-PEG4000-Maleimide composite nano-micelle cancer cells and paclitaxel-carrying composite nano-micelle cancer cells were given toxicity tests. Stability tests showed that self stability of PLA-block-PAAA (63/8) nano-micelle was not sufficient; the stability was good when the molar ratio of PLA-block-PAAA and PLA-PEG4000-Maleimide composite nano-micelle was 3:1; paclitaxel-carrying composite nano-micelle had good stability within 48 hours; PAAA segment had an inhibiting effect on C6 cancer cells and paclitaxel-carrying composite nano-micelle had a strong inhibiting effect also on tumors. After 24 hours, with the continuous release of paclitaxel, the tumor inhibiting effect of paclitaxel-carrying composite nano-micelle enhanced gradually, and the controlled-release of drugs had continuous inhibiting effect on tumor cells. Therefore, PAAA segment and paclitaxel had time-postponed synergistic effect. In conclusion, vitamin C-contained composite nanometer drug carrier materials can deliver anti-cancer drugs to nidus and thus inhibit tumor cells.
authors.affiliation: Deparment of Pharmacy, Jining No.1 Peoples Hospital, Jining, China.
authors.forename: H Z
authors.initials: HZ
authors.lastname: Liu
authors.affiliation: Department of Clinical Laboratory, Jining No. 1 Peoples Hospital, Jining, China.
authors.forename: X M
authors.initials: XM
authors.lastname: Liu
authors.affiliation: Deparment of Pharmacy, Jining No.1 Peoples Hospital, Jining, China.
authors.forename: X C
authors.initials: XC
authors.lastname: Liu
authors.affiliation: Department of Pharmacy, Jining Municipal Authority Hospital, Jining, China.
authors.forename: C Z
authors.initials: CZ
authors.lastname: Zhang
authors.affiliation: Deparment of Pharmacy, Jining No.1 Peoples Hospital, Jining, China.
authors.forename: H Q
authors.initials: HQ
authors.lastname: Liu
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001205:Ascorbic Acid / Q000008:administration & dosage*; D045744:Cell Line, Tumor; D004337:Drug Carriers; D016503:Drug Delivery Systems; D006801:Humans; D007773:Lactates / Q000008:administration & dosage; D008301:Maleimides / Q000008:administration & dosage; D008823:Micelles; D053758:Nanoparticles; D017239:Paclitaxel / Q000008:administration & dosage; D011092:Polyethylene Glycols / Q000008:administration & dosage
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D007773:Lactates; D008301:Maleimides; D008823:Micelles; C088513:poly(lactic acid-ethylene glycol); C043592:maleimide; D011092:Polyethylene Glycols; D017239:Paclitaxel; D001205:Ascorbic Acid