title: Exosomes expand the sphere of influence of Eph receptors and ephrins.
abstract: Membrane-anchored Eph receptors and ephrins represent a ubiquitous intercellular communication system that typically engages at sites of cell-cell contact to initiate bidirectional signaling. Gong et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201601085) show that cells can deploy the EphB2 receptor on exosomes to activate ephrinB signaling and collapse the growth cones of distant neurons.
authors.affiliation: Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037 elenap@sbpdiscovery.org.
authors.forename: Elena B
authors.initials: EB
authors.lastname: Pasquale
mesh_terms: D000818:Animals; D002450:Cell Communication; D002462:Cell Membrane / Q000378:metabolism; D036342:Ephrins / Q000378:metabolism*; D055354:Exosomes / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D036081:Receptors, Eph Family / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D036342:Ephrins; D036081:Receptors, Eph Family