title: Highly Sensitive Bisphenol-A Electrochemical Aptasensor Based on Poly(Pyrrole-Nitrilotriacetic Acid)-Aptamer Film.
abstract: An electrochemical highly sensitive aptasensor was developed based on electropolymerized poly(pyrrole-nitrilotriacetic) acid film and a new aptamer functionalized by a pentahistidine peptide for the quantification of bisphenol A. A surface coverage of antibisphenol A aptamer of 1.84 × 10(-10) mol cm(-2) was estimated from the electrochemical signal of the [Ru(III)(NH3)6](3+) complex bound by electrostatic interactions onto the aptamer-modified electrode. The binding of bisphenol A onto the polymer film was successfully characterized by electrochemical methods as square wave voltammetry and electrochemical impedance spectroscopy measurements. The designed label-free impedimetric aptasensor displayed a wide linear range from 10(-11) to 10(-6) mol L(-1) with a sensitivity of 372 Ω per unit of log of concentration and an excellent specificity toward interfering agents such as 4,4'-dihydroxybiphenyl and bisphenol P.
authors.affiliation: Univ. Grenoble Alpes, Département de Chimie Moléculaire, UMR CNRS 5250 , 570 rue de la Chimie, CS 40700, 38058 Grenoble cedex 9, France.|Université de Jijel , Laboratoire de Matériaux: Elaborations-Propriétés-Applications, BP 98, Ouled Aissa, 18000 Jijel, Algeria.
authors.forename: Imen
authors.initials: I
authors.lastname: Kazane
authors.affiliation: Univ. Grenoble Alpes, Département de Chimie Moléculaire, UMR CNRS 5250 , 570 rue de la Chimie, CS 40700, 38058 Grenoble cedex 9, France.
authors.forename: Karine
authors.initials: K
authors.lastname: Gorgy
authors.affiliation: Univ. Grenoble Alpes, Département de Chimie Moléculaire, UMR CNRS 5250 , 570 rue de la Chimie, CS 40700, 38058 Grenoble cedex 9, France.
authors.forename: Chantal
authors.initials: C
authors.lastname: Gondran
authors.affiliation: Univ. Grenoble Alpes, Département de Chimie Moléculaire, UMR CNRS 5250 , 570 rue de la Chimie, CS 40700, 38058 Grenoble cedex 9, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Spinelli
authors.affiliation: Université de Jijel , Laboratoire de Matériaux: Elaborations-Propriétés-Applications, BP 98, Ouled Aissa, 18000 Jijel, Algeria.
authors.forename: Ali
authors.initials: A
authors.lastname: Zazoua
authors.affiliation: Univ. Grenoble Alpes, Département de Chimie Moléculaire, UMR CNRS 5250 , 570 rue de la Chimie, CS 40700, 38058 Grenoble cedex 9, France.
authors.forename: E
authors.initials: E
authors.lastname: Defrancq
authors.affiliation: Univ. Grenoble Alpes, Département de Chimie Moléculaire, UMR CNRS 5250 , 570 rue de la Chimie, CS 40700, 38058 Grenoble cedex 9, France.
authors.forename: Serge
authors.initials: S
authors.lastname: Cosnier