title: Stress Response and Translation Control in Rotavirus Infection.
abstract: The general stress and innate immune responses are closely linked and overlap at many levels. The outcomes of these responses serve to reprogram host expression patterns to prevent viral invasions. In turn, viruses counter attack these cell responses to ensure their replication. The mechanisms by which viruses attempt to control host cell responses are as varied as the number of different virus families. One of the most recurrent strategies used by viruses to control the antiviral response of the cell is to hijack the translation machinery of the host, such that viral proteins are preferentially synthesized, while the expression of the stress and antiviral responses of the cell are blocked at the translation level. Here, we will review how rotaviruses, an important agent of acute severe gastroenteritis in children, overcome the stress responses of the cell to establish a productive infectious cycle.
authors.affiliation: Departamento de G&#233;netica del Desarrollo y Fisiolog&#237;a Molecular, Instituto de Biotecnolog&#237;a, Universidad Nacional Aut&#243;noma de M&#233;xico, Avenida Universidad 2001, Colonia Chamilpa, Cuernavaca, Morelos 62210, Mexico. susana@ibt.unam.mx.
authors.forename: Susana
authors.initials: S
authors.lastname: López
authors.affiliation: Departamento de G&#233;netica del Desarrollo y Fisiolog&#237;a Molecular, Instituto de Biotecnolog&#237;a, Universidad Nacional Aut&#243;noma de M&#233;xico, Avenida Universidad 2001, Colonia Chamilpa, Cuernavaca, Morelos 62210, Mexico. oca@ibt.unam.mx.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Oceguera
authors.affiliation: Departamento de G&#233;netica del Desarrollo y Fisiolog&#237;a Molecular, Instituto de Biotecnolog&#237;a, Universidad Nacional Aut&#243;noma de M&#233;xico, Avenida Universidad 2001, Colonia Chamilpa, Cuernavaca, Morelos 62210, Mexico. carlossj@ibt.unam.mx.
authors.forename: Carlos
authors.initials: C
authors.lastname: Sandoval-Jaime
mesh_terms: D005786:Gene Expression Regulation; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D014176:Protein Biosynthesis; D012401:Rotavirus / Q000276:immunology* / Q000472:pathogenicity*; D012400:Rotavirus Infections / Q000276:immunology* / Q000473:pathology*; D013312:Stress, Physiological; D014779:Virus Replication
keywords: RNA granules; antiviral response; processing bodies; protein synthesis; rotavirus; stress granules; stress response; unfolded protein response