title: Britanin attenuates ovalbumin-induced airway inflammation in a murine asthma model.
abstract: We previously demonstrated the alleviation of ovalbumin (OVA)-induced airway inflammation by Inulae flos. In the present study, the effects of britanin, a sesquiterpene compound isolated from Inulae flos, were evaluated in an in vivo animal model for anti-asthma activity through observation of airway hyperresponsiveness (AHR), eosinophil recruitment, Th2 cytokine and IgE levels, and lung histopathology. Britanin administration effectively reduced AHR induced by aerosolized methacholine, airway eosinophilia, Th2 cytokines in bronchoalveolar lavage fluids and the supernatant of cultured splenocytes compared with OVA-induced mice. Histological studies showed that increased inflammatory cell infiltration and mucus secretion were reduced by britanin administration. Thus, britanin may have therapeutic potential for treating allergic asthma.
authors.affiliation: Research and Development Division, National Development Institute of Korean Medicine, Gyeongsan, 712-260, Republic of Korea.
authors.forename: Sun-Gun
authors.initials: SG
authors.lastname: Kim
authors.affiliation: Research and Development Division, National Development Institute of Korean Medicine, Gyeongsan, 712-260, Republic of Korea.
authors.forename: Eujin
authors.initials: E
authors.lastname: Lee
authors.affiliation: Research and Development Division, National Development Institute of Korean Medicine, Gyeongsan, 712-260, Republic of Korea.
authors.forename: Na-Young
authors.initials: NY
authors.lastname: Park
authors.affiliation: Research and Development Division, National Development Institute of Korean Medicine, Gyeongsan, 712-260, Republic of Korea.
authors.forename: Hyo-Hyun
authors.initials: HH
authors.lastname: Park
authors.affiliation: Research and Development Division, National Development Institute of Korean Medicine, Gyeongsan, 712-260, Republic of Korea.
authors.forename: Kyu-Tae
authors.initials: KT
authors.lastname: Jeong
authors.affiliation: Department of Clinical Pathology, Daekyeung University, Gyeongsan, 712-719, Republic of Korea.
authors.forename: Keuk-Jun
authors.initials: KJ
authors.lastname: Kim
authors.affiliation: School of Medicine, Catholic University, Daegu, 705-718, Republic of Korea.
authors.forename: Youn Ju
authors.initials: YJ
authors.lastname: Lee
authors.affiliation: Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, 300070, Tianjin, People's Republic of China.
authors.forename: Meihua
authors.initials: M
authors.lastname: Jin
authors.affiliation: Research and Development Division, National Development Institute of Korean Medicine, Gyeongsan, 712-260, Republic of Korea. eklee@ynu.ac.kr.
authors.forename: Eunkyung
authors.initials: E
authors.lastname: Lee
mesh_terms: D000818:Animals; D001249:Asthma / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D004195:Disease Models, Animal; D005260:Female; D007249:Inflammation / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control; D018836:Inflammation Mediators / Q000037:antagonists & inhibitors* / Q000378:metabolism; D007783:Lactones / Q000494:pharmacology / Q000627:therapeutic use*; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000633:toxicity*; D012717:Sesquiterpenes / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D018836:Inflammation Mediators; D007783:Lactones; D012717:Sesquiterpenes; C575454:britannin; D010047:Ovalbumin
keywords: Airway hyperresponsiveness (AHR); Britanin; Bronchoalveolar lavage fluids (BALF); Eosinophils; Inulae flos