title: [Relationships of glucose transporter 4 with cognitive changes induced by high fat diet and glucose metabolism in hippocampus].
abstract: The hippocampus not only plays a role in appetite and energy balance, but also is particularly important in learning and memory. Figuring out the relationships of hippocampal glucose transporter 4 (GLUT4) with hippocampal glucose metabolism and hippocampus-dependent cognitive function is very important to clearly understand the pathophysiological basis of nutritional obesity and diabetes-related diseases, and treat obesity and cognitive dysfunction. Therefore, this study reviewed recent researches conducted on hippocampal GLUT4, hippocampal glucose metabolism, and hippocampus-dependent cognitive function. In this review, we mainly discussed: (1) The structure of GLUT4 and the distribution and function of GLUT4 in the hippocampus; (2) The translocation of GLUT4 in the hippocampus; (3) The relationships of the PI3K-Akt-GLUT4 signaling pathway with the high fat diet-induced changes of cognitive function and the glucose metabolism in the hippocampus; (4) The associations of the PI3K-Akt-GLUT4 signaling pathway with the diabetes-related cognitive dysfunction in the hippocampus; (5) The potential mechanisms of cognitive dysfunction induced by glucose metabolic disorder.
authors.affiliation: Shanghai Key Laboratory of Human Sport Competence Development and Maintenance, School of Sport Science, Shanghai University of Sport, Shanghai 200438, China.|Theory Teaching and Research Section, Department of Physical Education, Liaocheng University, Liaocheng 252059, China. zhangyunli@lcu.edu.cn.
authors.forename: Yun-Li
authors.initials: YL
authors.lastname: Zhang
authors.affiliation: Theory Teaching and Research Section, Department of Physical Education, Liaocheng University, Liaocheng 252059, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
mesh_terms: D003071:Cognition; D059305:Diet, High-Fat; D005947:Glucose; D051275:Glucose Transporter Type 4; D006624:Hippocampus; D015398:Signal Transduction
chemical_list: D051275:Glucose Transporter Type 4; D005947:Glucose