title: Salience Network Connectivity in Autism Is Related to Brain and Behavioral Markers of Sensory Overresponsivity.
abstract: The salience network, an intrinsic brain network thought to modulate attention to internal versus external stimuli, has been consistently found to be atypical in autism spectrum disorders (ASD). However, little is known about how this altered resting-state connectivity relates to brain activity during information processing, which has important implications for understanding sensory overresponsivity (SOR), a common and impairing condition in ASD related to difficulty downregulating brain responses to sensory stimuli. This study examined how SOR in youth with ASD relates to atypical salience network connectivity and whether these atypicalities are associated with abnormal brain response to basic sensory information.
  
  
  
  Functional magnetic resonance imaging was used to examine how parent-rated SOR symptoms related to salience network connectivity in 61 youth (aged 8-17 years; 28 with ASD and 33 IQ-matched typically developing youth). Correlations between resting-state salience network connectivity and brain response to mildly aversive tactile and auditory stimuli were examined.
  
  
  
  SOR in youth with ASD was related to increased resting-state functional connectivity between salience network nodes and brain regions implicated in primary sensory processing and attention. Furthermore, the strength of this connectivity at rest was related to the extent of brain activity in response to auditory and tactile stimuli.
  
  
  
  Results support an association between intrinsic brain connectivity and specific atypical brain responses during information processing. In addition, findings suggest that basic sensory information is overly salient to individuals with SOR, leading to overattribution of attention to this information. Implications for intervention include incorporating sensory coping strategies into social interventions for individuals with SOR.
authors.affiliation: Psychiatry and Biobehavioral Sciences, Semel Institute of Neuroscience and Human Behavior, University of California, Los Angeles. Electronic address: shulamite@ucla.edu.
authors.forename: Shulamite A
authors.initials: SA
authors.lastname: Green
authors.affiliation: Psychiatry and Biobehavioral Sciences, Semel Institute of Neuroscience and Human Behavior, University of California, Los Angeles.
authors.forename: Leanna
authors.initials: L
authors.lastname: Hernandez
authors.affiliation: Psychiatry and Biobehavioral Sciences, Semel Institute of Neuroscience and Human Behavior, University of California, Los Angeles.
authors.forename: Susan Y
authors.initials: SY
authors.lastname: Bookheimer
authors.affiliation: Psychiatry and Biobehavioral Sciences, Semel Institute of Neuroscience and Human Behavior, University of California, Los Angeles.
authors.forename: Mirella
authors.initials: M
authors.lastname: Dapretto
mesh_terms: D000293:Adolescent; D000067877:Autism Spectrum Disorder / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002648:Child; D063132:Connectome; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012678:Sensation Disorders / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*
keywords: autism spectrum disorders; fMRI; resting state; salience network; sensory overresponsivity