title: Tumor microenvironment on the move and the Aselli connection.
abstract: The tumor microenvironment is involved in many activities that promote tumor cell growth, local spreading, and metastasis. In this issue of Science Signaling, Jung et al found that lymphangiogenesis may result from the cooperation of two molecules, sphingosine-1-phosphate (S1P) and lipocalin 2 (LCN2), produced by tumor cells and macrophages, respectively. The new S1P-LCN2 axis stresses the importance of innate immunity in remodeling the tumor microenvironment and in lymphangiogenesis.
authors.affiliation: The Laboratory of Immunology, Department of Medicine and Moores Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, San Diego, CA 92093-0815, USA.
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Rodvold
authors.affiliation: The Laboratory of Immunology, Department of Medicine and Moores Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, San Diego, CA 92093-0815, USA. mzanetti@ucsd.edu.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Zanetti
mesh_terms: D000818:Animals; D006801:Humans; D000071068:Lipocalin-2 / Q000378:metabolism*; D008246:Lysophospholipids / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism*; D015398:Signal Transduction; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000378:metabolism; D059016:Tumor Microenvironment
chemical_list: C489506:LCN2 protein, human; D000071068:Lipocalin-2; D008246:Lysophospholipids; D009363:Neoplasm Proteins; C060506:sphingosine 1-phosphate; D013110:Sphingosine