title: Effect of Age on Blood Rheology in Sickle Cell Anaemia and Sickle Cell Haemoglobin C Disease: A Cross-Sectional Study.
abstract: OBJECTIVE
  Blood rheology plays a key role in the pathophysiology of sickle cell anaemia (SS) and sickle cell haemoglobin C disease (SC), but its evolution over the lifespan is unknown.
  
  
  METHODS
  Blood viscosity, red blood cell (RBC) deformability and aggregation, foetal haemoglobin (HbF) and haematocrit were measured in 114 healthy individuals (AA), 267 SS (161 children + 106 adults) and 138 SC (74 children + 64 adults) patients.
  
  
  RESULTS
  Our results showed that 1) RBC deformability is at its maximal value during the early years of life in SS and SC populations, mainly because HbF level is also at its peak, 2) during childhood and adulthood, hydroxycarbamide treatment, HbF level and gender modulated RBC deformability in SS patients, independently of age, 3) blood viscosity is higher in older SS and SC patients compared to younger ones and 4) haematocrit decreases as SS patients age.
  
  
  CONCLUSIONS
  The hemorheological changes detected in older patients could play a role in the progressive development of several chronic disorders in sickle cell disease, whose prevalence increases with age. Retarding these age-related haemorheological impairments, by using suitable drugs, may minimize the risks of vaso-occlusive events and chronic disorders.
authors.affiliation: Unité de Pathologie Moléculaire du Globule Rouge, Laboratoire de Biochimie et de Biologie Moléculaire, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France.|Laboratoire Interuniversitaire de Biologie de la Motricité, Equipe "Vascular Biology and Red Blood Cell", Université Claude Bernard Lyon 1, Lyon, France.|Laboratoire d'Excellence du Globule Rouge (LABEX GR-Ex), PRES Sorbonne, Paris, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Renoux
authors.affiliation: UMR Inserm U1134, Université des Antilles et de la Guyane, Hôpital de Pointe-à-Pitre, Hôpital Ricou, 97159 Pointe-à-Pitre Cedex, Guadeloupe, France.|Laboratoire d'Excellence du Globule Rouge (LABEX GR-Ex), PRES Sorbonne, Paris, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Romana
authors.affiliation: Unité de Pathologie Moléculaire du Globule Rouge, Laboratoire de Biochimie et de Biologie Moléculaire, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France.|Laboratoire Interuniversitaire de Biologie de la Motricité, Equipe "Vascular Biology and Red Blood Cell", Université Claude Bernard Lyon 1, Lyon, France.|Laboratoire d'Excellence du Globule Rouge (LABEX GR-Ex), PRES Sorbonne, Paris, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Joly
authors.affiliation: UMR Inserm U1134, Université des Antilles et de la Guyane, Hôpital de Pointe-à-Pitre, Hôpital Ricou, 97159 Pointe-à-Pitre Cedex, Guadeloupe, France.|Laboratoire d'Excellence du Globule Rouge (LABEX GR-Ex), PRES Sorbonne, Paris, France.
authors.forename: Séverine
authors.initials: S
authors.lastname: Ferdinand
authors.affiliation: Laboratoire Interuniversitaire de Biologie de la Motricité, Equipe "Vascular Biology and Red Blood Cell", Université Claude Bernard Lyon 1, Lyon, France.|Laboratoire d'Excellence du Globule Rouge (LABEX GR-Ex), PRES Sorbonne, Paris, France.
authors.forename: Camille
authors.initials: C
authors.lastname: Faes
authors.affiliation: Unité Transversale de la Drépanocytose, Hôpital de Pointe-à-Pitre, Hôpital Ricou, 97159 Pointe-à-Pitre Cedex, Guadeloupe, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Lemonne
authors.affiliation: Laboratoire Interuniversitaire de Biologie de la Motricité, Equipe "Vascular Biology and Red Blood Cell", Université Claude Bernard Lyon 1, Lyon, France.|Laboratoire d'Excellence du Globule Rouge (LABEX GR-Ex), PRES Sorbonne, Paris, France.
authors.forename: Sarah
authors.initials: S
authors.lastname: Skinner
authors.affiliation: Institut d'Hématologie et d'Oncologie Pédiatrique, Hospices Civils de Lyon, Lyon, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Garnier
authors.affiliation: Unité Transversale de la Drépanocytose, Hôpital de Pointe-à-Pitre, Hôpital Ricou, 97159 Pointe-à-Pitre Cedex, Guadeloupe, France.
authors.forename: Maryse
authors.initials: M
authors.lastname: Etienne-Julan
authors.affiliation: Institut d'Hématologie et d'Oncologie Pédiatrique, Hospices Civils de Lyon, Lyon, France.
authors.forename: Yves
authors.initials: Y
authors.lastname: Bertrand
authors.affiliation: Unité Transversale de la Drépanocytose, Hôpital de Pointe-à-Pitre, Hôpital Ricou, 97159 Pointe-à-Pitre Cedex, Guadeloupe, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Petras
authors.affiliation: Service de Médecine Interne, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Cannas
authors.affiliation: Unité Transversale de la Drépanocytose, Hôpital de Pointe-à-Pitre, Hôpital Ricou, 97159 Pointe-à-Pitre Cedex, Guadeloupe, France.
authors.forename: Lydia
authors.initials: L
authors.lastname: Divialle-Doumdo
authors.affiliation: Laboratoire Interuniversitaire de Biologie de la Motricité, Equipe "Vascular Biology and Red Blood Cell", Université Claude Bernard Lyon 1, Lyon, France.|Laboratoire d'Excellence du Globule Rouge (LABEX GR-Ex), PRES Sorbonne, Paris, France.
authors.forename: Elie
authors.initials: E
authors.lastname: Nader
authors.affiliation: Institut d'Hématologie et d'Oncologie Pédiatrique, Hospices Civils de Lyon, Lyon, France.
authors.forename: Daniela
authors.initials: D
authors.lastname: Cuzzubbo
authors.affiliation: UMR Inserm U1134, Université des Antilles et de la Guyane, Hôpital de Pointe-à-Pitre, Hôpital Ricou, 97159 Pointe-à-Pitre Cedex, Guadeloupe, France.|Laboratoire d'Excellence du Globule Rouge (LABEX GR-Ex), PRES Sorbonne, Paris, France.
authors.forename: Yann
authors.initials: Y
authors.lastname: Lamarre
authors.affiliation: Institut d'Hématologie et d'Oncologie Pédiatrique, Hospices Civils de Lyon, Lyon, France.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Gauthier
authors.affiliation: UMR Inserm U1134, Université des Antilles et de la Guyane, Hôpital de Pointe-à-Pitre, Hôpital Ricou, 97159 Pointe-à-Pitre Cedex, Guadeloupe, France.|Laboratoire d'Excellence du Globule Rouge (LABEX GR-Ex), PRES Sorbonne, Paris, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Waltz
authors.affiliation: Institut d'Hématologie et d'Oncologie Pédiatrique, Hospices Civils de Lyon, Lyon, France.
authors.forename: Kamila
authors.initials: K
authors.lastname: Kebaili
authors.affiliation: Laboratoire Interuniversitaire de Biologie de la Motricité, Equipe "Vascular Biology and Red Blood Cell", Université Claude Bernard Lyon 1, Lyon, France.|Laboratoire d'Excellence du Globule Rouge (LABEX GR-Ex), PRES Sorbonne, Paris, France.
authors.forename: Cyril
authors.initials: C
authors.lastname: Martin
authors.affiliation: Service de Médecine Interne, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Hot
authors.affiliation: UMR Inserm U1134, Université des Antilles et de la Guyane, Hôpital de Pointe-à-Pitre, Hôpital Ricou, 97159 Pointe-à-Pitre Cedex, Guadeloupe, France.|Laboratoire d'Excellence du Globule Rouge (LABEX GR-Ex), PRES Sorbonne, Paris, France.
authors.forename: Marie-Dominique
authors.initials: MD
authors.lastname: Hardy-Dessources
authors.affiliation: Laboratoire Interuniversitaire de Biologie de la Motricité, Equipe "Vascular Biology and Red Blood Cell", Université Claude Bernard Lyon 1, Lyon, France.|Service de Médecine Interne, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France.|Laboratoire d'Excellence du Globule Rouge (LABEX GR-Ex), PRES Sorbonne, Paris, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Pialoux
authors.affiliation: Laboratoire Interuniversitaire de Biologie de la Motricité, Equipe "Vascular Biology and Red Blood Cell", Université Claude Bernard Lyon 1, Lyon, France.|UMR Inserm U1134, Université des Antilles et de la Guyane, Hôpital de Pointe-à-Pitre, Hôpital Ricou, 97159 Pointe-à-Pitre Cedex, Guadeloupe, France.|Laboratoire d'Excellence du Globule Rouge (LABEX GR-Ex), PRES Sorbonne, Paris, France.|Institut Universitaire de France (IUF), Paris, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Connes
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000755:Anemia, Sickle Cell / Q000097:blood*; D001809:Blood Viscosity; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004903:Erythrocyte Aggregation / Q000187:drug effects; D004907:Erythrocyte Deformability; D005260:Female; D064368:Healthy Volunteers; D006400:Hematocrit; D006444:Hemoglobin C / Q000096:biosynthesis*; D018056:Hemorheology; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D015999:Multivariate Analysis; D014783:Viscosity; D055815:Young Adult
chemical_list: D006444:Hemoglobin C; D006918:Hydroxyurea