title: Rewiring macrophages for anti-tumour immunity.
abstract: Tumour-associated macrophages facilitate cancer progression, but whether they can be reprogrammed to elicit an anti-tumour response remains unclear. Deletion of the microRNA-processing enzyme Dicer is now shown to rewire macrophages to an anti-tumour mode, leading to an enhanced response to immunotherapy and inhibition of tumour progression.
authors.affiliation: Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), #04 Immunos, 8A Biomedical Grove, Singapore 138648.
authors.forename: Yunqin
authors.initials: Y
authors.lastname: Lee
authors.affiliation: Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), #04 Immunos, 8A Biomedical Grove, Singapore 138648.
authors.forename: Subhra K
authors.initials: SK
authors.lastname: Biswas
mesh_terms: D000818:Animals; D065150:Cellular Reprogramming; D018450:Disease Progression; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D008264:Macrophages / Q000276:immunology*; D009369:Neoplasms / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy; D043244:Ribonuclease III / Q000276:immunology / Q000378:metabolism*
chemical_list: D043244:Ribonuclease III