title: Nickel-Catalyzed Reductive Amidation of Unactivated Alkyl Bromides.
abstract: A user-friendly, nickel-catalyzed reductive amidation of unactivated primary, secondary, and tertiary alkyl bromides with isocyanates is described. This catalytic strategy offers an efficient synthesis of a wide range of aliphatic amides under mild conditions and with an excellent chemoselectivity profile while avoiding the use of stoichiometric and sensitive organometallic reagents.
authors.affiliation: Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology, Av. Països Catalans 16, 43007, Tarragona, Spain.
authors.forename: Eloisa
authors.identifier: 0000-0001-7045-9325
authors.initials: E
authors.lastname: Serrano
authors.affiliation: Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology, Av. Països Catalans 16, 43007, Tarragona, Spain. rmartinromo@iciq.es.|Catalan Institution for Research and Advanced Studies (ICREA), Passeig Lluïs Companys 23, 08010, Barcelona, Spain. rmartinromo@iciq.es.
authors.forename: Ruben
authors.identifier: 0000-0002-2543-0221
authors.initials: R
authors.lastname: Martin
keywords: cross-coupling; nickel; reductive coupling; synthetic methods