title: The CDH1 -160C/A polymorphism is associated with breast cancer: evidence from a meta-analysis.
abstract: BACKGROUND
  Numerous epidemiological studies have evaluated the association between the CDH1 -160C/A polymorphism and the risk of breast cancers. However, these studies have yielded conflicting results. To derive a more precise estimation of this association, this meta-analysis was conducted.
  
  
  METHODS
  A comprehensive search using the keywords "CDH1," "E-Cadherin," "polymorphism," "SNP," and "variant" combined with "breast," "cancer," "tumor," or "carcinomas" was conducted. Pooled odds ratios (ORs) with 95 % confidence intervals (CIs) were appropriately calculated using a fixed effect or random effect model. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2009 checklist was used for this meta-analysis.
  
  
  RESULTS
  Four publications including five studies were identified. It was found that the CDH1 -160C/A polymorphism was significantly associated with breast cancer risk in the dominant model (CA + AA vs. CC: OR = 1.207, 95 % CI = 1.031-1.412, P = 0.019).
  
  
  CONCLUSIONS
  Our meta-analysis demonstrated that the -160C/A polymorphism in the CDH1 gene might contribute to breast cancer susceptibility. Further investigations using a much larger sample including different ethnicities are still needed to verify this association.
authors.affiliation: Key Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People's Hospital, Hangzhou, 310014, China.
authors.forename: Ying-Yu
authors.initials: YY
authors.lastname: Ma
authors.affiliation: Digestive System Department, Zhejiang Provincial People's Hospital, Hangzhou, 310014, China.
authors.forename: Wei-Quan
authors.initials: WQ
authors.lastname: Wu
authors.affiliation: Key Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People's Hospital, Hangzhou, 310014, China.
authors.forename: Zheng-Chuang
authors.initials: ZC
authors.lastname: Liu
authors.affiliation: Operation Room, Zhejiang Provincial People's Hospital, Hangzhou, 310014, China.
authors.forename: Xiao-Fen
authors.initials: XF
authors.lastname: Yu
authors.affiliation: Wenzhou Medical University, Wenzhou, 310025, Zhejiang Province, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Guo
authors.affiliation: Wenzhou Medical University, Wenzhou, 310025, Zhejiang Province, China.
authors.forename: Qi-Wen
authors.initials: QW
authors.lastname: He
authors.affiliation: Wenzhou Medical University, Wenzhou, 310025, Zhejiang Province, China.
authors.forename: Shi-Bin
authors.initials: SB
authors.lastname: Jiang
authors.affiliation: Department of Gastrointestinal Surgery, Zhejiang Provincial People's Hospital, Hangzhou, 310014, China.
authors.forename: Qin-Shu
authors.initials: QS
authors.lastname: Shao
authors.affiliation: Key Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People's Hospital, Hangzhou, 310014, China. taohouquan2008@aliyun.com.|Department of Gastrointestinal Surgery, Zhejiang Provincial People's Hospital, Hangzhou, 310014, China. taohouquan2008@aliyun.com.
authors.forename: Hou-Quan
authors.initials: HQ
authors.lastname: Tao
authors.affiliation: Department of Gastrointestinal Surgery, Zhejiang Provincial People's Hospital, Hangzhou, 310014, China. dshuang@zju.edu.cn.
authors.forename: Dong-Sheng
authors.initials: DS
authors.lastname: Huang
mesh_terms: D015703:Antigens, CD; D001943:Breast Neoplasms / Q000235:genetics*; D015820:Cadherins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors
chemical_list: D015703:Antigens, CD; C513384:CDH1 protein, human; D015820:Cadherins
keywords: Breast cancer; CDH1; Meta-analysis; Polymorphism