title: Phenolic compounds and biological effects of edible Rumex scutatus and Pseudosempervivum sempervivum: potential sources of natural agents with health benefits.
abstract: The present study outlines a chemical characterization and further effects beneficial to health of edible Rumex scutatus and Pseudosempervivum sempervivum, in addition to presenting the antioxidant, enzyme inhibitory effects and antimicrobial properties of different extracts. The phenolic compounds composition of the extracts was assessed by RP-HPLC-DAD, outlining benzoic acid and rutin as major constituents in P. sempervivum and rutin and hesperidin in R. scutatus. Moreover, further biological effects were tested on key enzymes involved in diabetes mellitus, Alzheimer's disease and skin melanogenesis revealing an important tyrosinase inhibitory effect of Pseudosempervivum water extract. Moreover, both species possessed antimicrobial properties towards bacteria and fungi relevant to public health. Accordingly, we find that R. scutatus and P. sempervivum can be considered as novel functional foods because they are rich sources of biologically active compounds that provide health benefits.
authors.affiliation: Department of Biology, Faculty of Science and Arts, Nigde University, Nigde, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Savran
authors.affiliation: Department of Biology, Faculty of Science, Selcuk University, Konya, Turkey. gokhanzengin@selcuk.edu.tr.
authors.forename: Gokhan
authors.initials: G
authors.lastname: Zengin
authors.affiliation: Department of Biology, Faculty of Science, Selcuk University, Konya, Turkey. gokhanzengin@selcuk.edu.tr.
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Aktumsek
authors.affiliation: Department of Pharmaceutical Botany, "Iuliu Hatieganu" University of Medicine and Pharmacy, 8, V. Babes Street, Cluj-Napoca, Romania.
authors.forename: Andrei
authors.initials: A
authors.lastname: Mocan
authors.affiliation: Institute for Biological Research "Siniša Stanković" University of Belgrade, Belgrade, Serbia. mris@ibiss.bg.ac.rs.
authors.forename: Jasmina
authors.initials: J
authors.lastname: Glamoćlija
authors.affiliation: Institute for Biological Research "Siniša Stanković" University of Belgrade, Belgrade, Serbia. mris@ibiss.bg.ac.rs.
authors.forename: Ana
authors.initials: A
authors.lastname: Ćirić
authors.affiliation: Institute for Biological Research "Siniša Stanković" University of Belgrade, Belgrade, Serbia. mris@ibiss.bg.ac.rs.
authors.forename: Marina
authors.initials: M
authors.lastname: Soković
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D019817:Benzoic Acid / Q000494:pharmacology; D001688:Biological Products / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D029627:Crassulaceae / Q000737:chemistry*; D055951:Functional Food; D005658:Fungi / Q000187:drug effects; D065089:Glycoside Hydrolase Inhibitors / Q000494:pharmacology; D006569:Hesperidin / Q000494:pharmacology; D010636:Phenols / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D031804:Rumex / Q000737:chemistry*; D012431:Rutin / Q000494:pharmacology; D000516:alpha-Amylases / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D000890:Anti-Infective Agents; D000975:Antioxidants; D001688:Biological Products; D002800:Cholinesterase Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D010636:Phenols; D010936:Plant Extracts; D012431:Rutin; D019817:Benzoic Acid; D006569:Hesperidin; D000516:alpha-Amylases