title: Lipoblastoma of the Labia: A Case Report.
abstract: BACKGROUND
  Vulvar masses are rare in prepubertal girls. Lipoblastomas are benign adipose tumors that arise from embryonic white fat and occur almost exclusively in infants and children.
  
  
  METHODS
  An 18-month-old female infant presented with a 2-cm mobile mass in the left labia majora. Imaging and examination revealed normal prepubertal gynecologic structures and a 4.5 cm fatty mass in the left labia. Surgical excision revealed a 3.8 cm well circumscribed adipose tissue mass consistent with maturing lipoblastoma on microscopic examination. Cytogenetic analysis revealed 79,XXX [7]/46,XX[13], a near-triploid clone.
  
  
  CONCLUSIONS
  The differential diagnosis of vulvar masses in children should include lipoblastoma. Although preoperative imaging has limited ability to differentiate lipomatous tumors, magnetic resonance imaging is the modality of choice for evaluating tumor extension and for surgical planning. Treatment is complete surgical excision with close follow-up for at least 5 years because of the high recurrence rate.
authors.affiliation: Department of Pediatrics, Texas Children's Hospital and Baylor College of Medicine, Houston, Texas; Division of Pediatric and Adolescent Gynecology, Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas. Electronic address: kchildre@bcm.edu.
authors.forename: Krista J
authors.initials: KJ
authors.lastname: Childress
authors.affiliation: Department of Pediatrics, Texas Children's Hospital and Baylor College of Medicine, Houston, Texas; Department of Pathology, Texas Children's Hospital and Baylor College of Medicine, Houston, Texas.
authors.forename: John
authors.initials: J
authors.lastname: Hicks
authors.affiliation: Department of Pathology, Texas Children's Hospital and Baylor College of Medicine, Houston, Texas.
authors.forename: Hao
authors.initials: H
authors.lastname: Wu
authors.affiliation: Michael E. DeBakey Department of Surgery, Division of Pediatric Surgery, Texas Children's Hospital and Baylor College of Medicine, Houston, Texas.
authors.forename: Mary L
authors.initials: ML
authors.lastname: Brandt
authors.affiliation: Department of Pediatrics, Texas Children's Hospital and Baylor College of Medicine, Houston, Texas; Division of Pediatric and Adolescent Gynecology, Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas.
authors.forename: Oluyemisi A
authors.initials: OA
authors.lastname: Adeyemi-Fowode
mesh_terms: D005260:Female; D006801:Humans; D007223:Infant; D062689:Lipoblastoma / Q000235:genetics / Q000473:pathology*; D014844:Vulva / Q000473:pathology; D014846:Vulvar Neoplasms / Q000235:genetics / Q000473:pathology*
keywords: Adipose tumor; Benign; Labia; Lipoblastoma; Pediatric; Soft tissue tumors