title: Maternal inhaled fluticasone propionate intake during pregnancy is detected in neonatal cord blood.
abstract: Despite recommendations to use inhaled corticosteroids as treatment to control asthma during pregnancy, it is unknown whether inhaled fluticasone propionate (FP) reaches the fetus. Results & methodology: We collected maternal blood on the morning following delivery. FP was detected by ultra-performance LC-MS/MS (UPLC-MS/MS) in 9/17 asthmatic women using FP. Delay between last FP inhalation and maternal blood sampling ranged between 3 and 33 h and FP was detected in a range of 1.572-46.440 pg/ml. Among the nine offspring of these FP users, FP was detected in five cord blood samples. Delay between last predelivery FP inhalation and cord blood sampling ranged from 4 to 20 h and FP was detected in a range of 0.423-4.510 pg/ml.
  
  
  
  Our findings demonstrate placental passage of inhaled FP.
authors.affiliation: Division of Endocrinology, Department of Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Battista
authors.affiliation: Division of Medical Genetics, Department of Pediatrics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
authors.forename: Michel
authors.initials: M
authors.lastname: Boutin
authors.affiliation: Division of Medical Genetics, Department of Pediatrics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
authors.forename: Philippe
authors.initials: P
authors.lastname: Venne
authors.affiliation: Centre de recherche du Centre hospitalier universitaire de Sherbrooke, Sherbrooke, Quebec, Canada.|Faculty of Pharmacy, Université de Montréal, Quebec, Canada.|Research Center, Hôpital du Sacré-Coeur de Montréal, Quebec, Canada.
authors.forename: Lucie
authors.initials: L
authors.lastname: Blais
authors.affiliation: Faculty of Pharmacy, Université de Montréal, Quebec, Canada.|CHU Ste-Justine Research Center, Montréal, Quebec, Canada.
authors.forename: Anick
authors.initials: A
authors.lastname: Bérard
authors.affiliation: Division of Endocrinology, Department of Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
authors.forename: Marilyn
authors.initials: M
authors.lastname: Lacroix
authors.affiliation: Division of Endocrinology, Department of Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
authors.forename: Julie
authors.initials: J
authors.lastname: Patenaude
authors.affiliation: Division of Endocrinology, Department of Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
authors.forename: Laetitia
authors.initials: L
authors.lastname: Guillemette
authors.affiliation: Centre de recherche du Centre hospitalier universitaire de Sherbrooke, Sherbrooke, Quebec, Canada.|Faculty of Pharmacy, Université de Montréal, Quebec, Canada.|Department of Pharmacy, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
authors.forename: Benoit
authors.initials: B
authors.lastname: Cossette
authors.affiliation: Division of Endocrinology, Department of Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec, Canada.|Centre de recherche du Centre hospitalier universitaire de Sherbrooke, Sherbrooke, Quebec, Canada.|Department of Population Medicine, Harvard Pilgrim Health Care Institute, Harvard Medical School, Boston, MA, USA.|Massachusetts General Hospital, Boston, MA, USA.
authors.forename: Marie-France
authors.initials: MF
authors.lastname: Hivert
authors.affiliation: Division of Medical Genetics, Department of Pediatrics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec, Canada.|Centre de recherche du Centre hospitalier universitaire de Sherbrooke, Sherbrooke, Quebec, Canada.
authors.forename: Christiane
authors.initials: C
authors.lastname: Auray-Blais
keywords: UPLC–MS/MS; asthma; cord blood; fluticasone propionate; pregnancy