title: Hollow hydroxyapatite microsphere: a promising carrier for bone tissue engineering.
abstract: Hydroxyapatite (HA) microsphere with abundant ordered mesoporous and large hollow structure was prepared at hydrothermal condition with the aid of citrate. The obtained microsphere was performed as a drug delivery carrier to evaluate its drug loading/releasing behaviour using alendronate (AL) as a model drug. Results revealed that HA particles performed high AL-loading capability (46.8 wt % with respect to the powdered starting materials) and excellent AL-releasing behaviour (sustained drug releasing profile without burst release). Besides, although a proliferation inhibition phenomenon was observed as HA and AL-loading HA (HA-AL) co-cultured with mesenchymal stem cells (MSCs) at the initial stage, after prolonging co-culture period, compared with HA and control group, HA-AL promoted the cells' proliferation, meanwhile, it facilitated osteogenic differentiation of MSCs and enhanced the expression level of typical markers, all of that ensure HA microsphere is a promising carrier for bone repair.
authors.affiliation: a School of Materials Science and Engineering, Jiangxi University of Science and Technology , Ganzhou , PR China.
authors.forename: Hui
authors.initials: H
authors.lastname: Yang
authors.affiliation: b School of Materials Science and Engineering, South China University of Technology , Guangzhou , PR China.
authors.forename: Huichang
authors.initials: H
authors.lastname: Gao
authors.affiliation: b School of Materials Science and Engineering, South China University of Technology , Guangzhou , PR China.
authors.forename: Yingjun
authors.initials: Y
authors.lastname: Wang
keywords: Hydroxyapatite; alendronate; drug delivery; mesoporous; osteogenesis