title: Wnt Signaling in Cancer Stem Cell Biology.
abstract: Aberrant regulation of Wnt signaling is a common theme seen across many tumor types. Decades of research have unraveled the epigenetic and genetic alterations that result in elevated Wnt pathway activity. More recently, it has become apparent that Wnt signaling levels identify stem-like tumor cells that are responsible for fueling tumor growth. As therapeutic targeting of these tumor stem cells is an intense area of investigation, a concise understanding on how Wnt activity relates to cancer stem cell traits is needed. This review attempts at summarizing the intricacies between Wnt signaling and cancer stem cell biology with a special emphasis on colorectal cancer.
authors.affiliation: Laboratory of Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM), Academic Medical Center (AMC), Amsterdam 1105AZ, The Netherlands. felipedesousamello@gmail.com.
authors.forename: Felipe
authors.initials: F
authors.lastname: de Sousa E Melo
authors.affiliation: Laboratory of Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM), Academic Medical Center (AMC), Amsterdam 1105AZ, The Netherlands. l.vermeulen@amc.uva.nl.
authors.forename: Louis
authors.initials: L
authors.lastname: Vermeulen
keywords: Wnt inhibition; Wnt signaling; cancer; cancer stem cell niche; cancer stem cells; stem cells; targeted therapy