title: Hepatotoxicity during Treatment for Tuberculosis in People Living with HIV/AIDS.
abstract: Hepatotoxicity is frequently reported as an adverse reaction during the treatment of tuberculosis. The aim of this study was to determine the incidence of hepatotoxicity and to identify predictive factors for developing hepatotoxicity after people living with HIV/AIDS (PLWHA) start treatment for tuberculosis. This was a prospective cohort study with PLWHA who were monitored during the first 60 days of tuberculosis treatment in Pernambuco, Brazil. Hepatotoxicity was considered increased levels of aminotransferase, namely those that rose to three times higher than the level before initiating tuberculosis treatment, these levels being associated with symptoms of hepatitis. We conducted a multivariate logistic regression analysis and the magnitude of the associations was expressed by the odds ratio with a confidence interval of 95%. Hepatotoxicity was observed in 53 (30.6%) of the 173 patients who started tuberculosis treatment. The final multivariate logistic regression model demonstrated that the use of fluconazole, malnutrition and the subject being classified as a phenotypically slow acetylator increased the risk of hepatotoxicity significantly. The incidence of hepatotoxicity during treatment for tuberculosis in PLWHA was high. Those classified as phenotypically slow acetylators and as malnourished should be targeted for specific care to reduce the risk of hepatotoxicity during treatment for tuberculosis. The use of fluconazole should be avoided during tuberculosis treatment in PLWHA.
authors.affiliation: Departamento de Medicina Tropical, Universidade Federal de Pernambuco, Recife, Brazil.
authors.forename: Carolline
authors.initials: C
authors.lastname: Araújo-Mariz
authors.affiliation: Departamento de Medicina Tropical, Universidade Federal de Pernambuco, Recife, Brazil.
authors.forename: Edmundo Pessoa
authors.initials: EP
authors.lastname: Lopes
authors.affiliation: Laboratório de Virologia, Centro de Pesquisas Aggeu Magalhães/FIOCRUZ, Recife, Brazil.
authors.forename: Bartolomeu
authors.initials: B
authors.lastname: Acioli-Santos
authors.affiliation: Hospital Correia Picanço, Secretaria de Saúde de Pernambuco, Recife, Brazil.
authors.forename: Magda
authors.initials: M
authors.lastname: Maruza
authors.affiliation: Instituto de Ciências Biológicas, Universidade de Pernambuco, Recife, Brazil.
authors.forename: Ulisses Ramos
authors.initials: UR
authors.lastname: Montarroyos
authors.affiliation: Departamento de Medicina Tropical, Universidade Federal de Pernambuco, Recife, Brazil.|Faculdade de Ciências Médicas, Universidade de Pernambuco, Recife, Brazil.
authors.forename: Ricardo Arraes de Alencar
authors.initials: RA
authors.lastname: Ximenes
authors.affiliation: Departamento de Medicina Tropical, Universidade Federal de Pernambuco, Recife, Brazil.
authors.forename: Heloísa Ramos
authors.initials: HR
authors.lastname: Lacerda
authors.affiliation: Faculdade de Ciências Médicas, Universidade de Pernambuco, Recife, Brazil.
authors.forename: Demócrito de Barros
authors.initials: Dde B
authors.lastname: Miranda-Filho
authors.affiliation: Departamento de Saúde Coletiva, Centro de Pesquisas Aggeu Magalhães/FIOCRUZ, Recife, Brazil.
authors.forename: Maria de Fátima P Militão de
authors.initials: Mde F
authors.lastname: Albuquerque
mesh_terms: D000107:Acetylation; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D000995:Antitubercular Agents / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use*; D001191:Arylamine N-Acetyltransferase / Q000235:genetics; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology*; D005260:Female; D005838:Genotype; D006801:Humans; D008019:Life Style; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D013997:Time Factors; D014376:Tuberculosis / Q000150:complications* / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents; D001191:Arylamine N-Acetyltransferase; C478900:NAT2 protein, human