title: Malnutrition in Alzheimer's Disease, Dementia with Lewy Bodies, and Frontotemporal Lobar Degeneration: Comparison Using Serum Albumin, Total Protein, and Hemoglobin Level.
abstract: Malnutrition among dementia patients is an important issue. However, the biochemical markers of malnutrition have not been well studied in this population. The purpose of this study was to compare biochemical blood markers among patients with Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and frontotemporal lobar degeneration (FTLD). A total of 339 dementia outpatients and their family caregivers participated in this study. Low serum albumin was 7.2 times more prevalent among patients with DLB and 10.1 times more prevalent among those with FTLD than among those with AD, with adjustment for age. Low hemoglobin was 9.1 times more common in female DLB patients than in female AD patients, with adjustment for age. The levels of biochemical markers were not significantly correlated with cognitive function. Family caregivers of patients with low total protein, low albumin, or low hemoglobin were asked if the patients had loss of weight or appetite; 96.4% reported no loss of weight or appetite. In conclusion, nutritional status was worse in patients with DLB and FTLD than in those with AD. A multidimensional approach, including blood testing, is needed to assess malnutrition in patients with dementia.
authors.affiliation: Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
authors.forename: Asuka
authors.identifier: http://orcid.org/0000-0002-4559-1460
authors.initials: A
authors.lastname: Koyama
authors.affiliation: Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
authors.forename: Mamoru
authors.initials: M
authors.lastname: Hashimoto
authors.affiliation: Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
authors.forename: Hibiki
authors.initials: H
authors.lastname: Tanaka
authors.affiliation: Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
authors.forename: Noboru
authors.initials: N
authors.lastname: Fujise
authors.affiliation: Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
authors.forename: Masateru
authors.initials: M
authors.lastname: Matsushita
authors.affiliation: Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Miyagawa
authors.affiliation: Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Hatada
authors.affiliation: Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
authors.forename: Ryuji
authors.initials: R
authors.lastname: Fukuhara
authors.affiliation: Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Hasegawa
authors.affiliation: Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
authors.forename: Shuji
authors.initials: S
authors.lastname: Todani
authors.affiliation: Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
authors.forename: Kengo
authors.initials: K
authors.lastname: Matsukuma
authors.affiliation: Faculty of Human Life Science, Shokei University, Kumamoto, Japan.
authors.forename: Michiyo
authors.initials: M
authors.lastname: Kawano
authors.affiliation: Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Ikeda
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D015415:Biomarkers; D017028:Caregivers; D005260:Female; D057174:Frontotemporal Lobar Degeneration / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D006454:Hemoglobins; D006801:Humans; D020961:Lewy Body Disease / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D008297:Male; D044342:Malnutrition / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology*; D016017:Odds Ratio; D010045:Outpatients; D015995:Prevalence; D012709:Serum Albumin
chemical_list: D015415:Biomarkers; D006454:Hemoglobins; D012709:Serum Albumin