title: Indicators of Moderate and Severe Preeclampsia in Correlation with Maternal IL10.
abstract: OBJECTIVE
  The purpose of the actual study was to evaluate the relationship between the formation of anti-inflammatory cytokine IL10 and several indicators of moderate and severe preeclampsia in the third trimester of pregnancy.
  
  
  METHODS
  Examination of the indicators of preeclampsia and maternal IL10 levels was conducted in 50 women with pregnancies complicated by varying degrees of preeclampsia in the third trimester of gestation as well as in 50 normotensive patients, hospitalized at the University Clinic of Gynecology and Obstetrics, Skopje, Republic of Macedonia. The levels of IL10 were determined with a commercial test developed by Orgenium Laboratories (Finland), using reagents from AviBion ELISA research kits. Patients with preeclampsia were categorized into moderate and severe preeclampsia group according to the degree of preeclampsia. Logistic regression analysis was used to determine the predictive value of different parameters for the occurrence of severe preeclampsia. Odds ratios and 95% Confidence Intervals were calculated in order to quantify independent associations.
  
  
  RESULTS
  The regression analysis detected systolic blood pressure (160 mmHg or higher), diastolic blood pressure (100 mmHg or higher), persistent proteinuria in pregnancy, serum LDH concentration (450 U/L or higher) and reduced serum concentrations of IL10 as significant predictors of severe preeclampsia in pregnant women after adjusting for age.
  
  
  CONCLUSIONS
  The findings of significantly lower serum IL10 concentrations in patients with severe preeclampsia in comparison with respective concentrations in patients with moderate preeclampsia can be considered as major pathognomonic laboratory sign of severe preeclampsia.
authors.affiliation: University Clinic of Obstetrics and Gynecology, Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
authors.forename: Ana Daneva
authors.initials: AD
authors.lastname: Markova
authors.affiliation: University Clinic of Obstetrics and Gynecology, Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
authors.forename: Marija
authors.initials: M
authors.lastname: Hadži-Lega
authors.affiliation: Institute for Occupational Health of Republic of Macedonia - WHO Collaborating Center and GA2LEN Collaborating Center, Skopje, Republic of Macedonia.
authors.forename: Dragan
authors.initials: D
authors.lastname: Mijakoski
keywords: IL10; Indicators; logistic regression; preeclampsia