title: The role of variants from the innate immune system genes in tuberculosis and skin test response in a Native American population.
abstract: Native American populations show higher tuberculosis (TB) mortality and infectivity rates than non-Native populations. Variants in the innate immune system seem to have an important role on TB susceptibility. The role of some innate immune system variants in TB susceptibility and/or skin test response (PPD) were investigated in the Aché, a Native American population. Complement receptor 1 and toll like receptor 9 variants were associated with anergy to PPD and protection to TB, respectively. These findings demonstrate an important role of the innate immune system variants in TB susceptibility.
authors.affiliation: Departamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Juliana D
authors.initials: JD
authors.lastname: Lindenau
authors.affiliation: Departamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Francisco M
authors.initials: FM
authors.lastname: Salzano
authors.affiliation: School of Human Evolution & Social Change, Arizona State University, Tempe, AZ, USA.
authors.forename: Ana M
authors.initials: AM
authors.lastname: Hurtado
authors.affiliation: School of Human Evolution & Social Change, Arizona State University, Tempe, AZ, USA.
authors.forename: Kim R
authors.initials: KR
authors.lastname: Hill
authors.affiliation: Departamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: mara.hutz@ufrgs.br.
authors.forename: Mara H
authors.initials: MH
authors.lastname: Hutz
mesh_terms: D000328:Adult; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics; D007199:Indians, South American; D008297:Male; D008875:Middle Aged; D010239:Paraguay; D020641:Polymorphism, Single Nucleotide; D011951:Receptors, Complement / Q000235:genetics; D051217:Toll-Like Receptor 9 / Q000235:genetics*; D014374:Tuberculin Test; D014397:Tuberculosis, Pulmonary / Q000235:genetics*; D055815:Young Adult
chemical_list: D011951:Receptors, Complement; C495371:TLR9 protein, human; D051217:Toll-Like Receptor 9
keywords: Amerindians; CR1; Innate immunity; TLR9; Tuberculosis