title: The role of sleep duration in diabetes and glucose control.
abstract: Sleep curtailment is common in the Westernised world and coincides with an increase in the prevalence of type 2 diabetes mellitus (T2DM). This review considers the recently published evidence for whether sleep duration is involved in the development of T2DM in human subjects and whether sleep has a role to play in glucose control in people who have diabetes. Data from large, prospective studies indicate a U-shaped relationship between sleep duration and the development of T2DM. Smaller, cross-sectional studies also support a relationship between short sleep duration and the development of both insulin resistance and T2DM. Intervention studies show that sleep restriction leads to insulin resistance, with recent sleep extension studies offering tantalising data showing a potential benefit of sleep extension on glucose control and insulin sensitivity. In people with established diabetes the published literature shows an association between poor glucose control and both short and long sleep durations. However, there are currently no studies that determine the causal direction of this relationship, nor whether sleep interventions are likely to offer benefit for people with diabetes to help them achieve tighter glucose control.
authors.affiliation: Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds,Leeds,UK.
authors.forename: Alia
authors.initials: A
authors.lastname: Alnaji
authors.affiliation: Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds,Leeds,UK.
authors.forename: Graham R
authors.initials: GR
authors.lastname: Law
authors.affiliation: Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds,Leeds,UK.
authors.forename: Eleanor M
authors.initials: EM
authors.lastname: Scott
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology / Q000378:metabolism* / Q000517:prevention & control; D006801:Humans; D007333:Insulin Resistance; D012890:Sleep
chemical_list: D001786:Blood Glucose
keywords:  HR hazard ratio;  T2DM type 2 diabetes mellitus; Circadian; Clock; Diabetes; Glucose; Insulin resistance; Sleep