title: The potential efficacy of Survanta (r) and Seprafilm (r) on preventing intra-abdominal adhesions in rats.
abstract: OBJECTIVE
  To investigate the potential efficacy of beractant (Survanta(r)) and Seprafilm(r) on the prevention of postoperative adhesions.
  
  
  METHODS
  Forty Wistar-albino female rats were used. The rats were randomly allocated into four groups of 10 rats each as control group (CG), beractant group (BG), Seprafilm(r) group (SG), and combined group (COG). All rats underwent cecal abrasion via midline laparotomy. Before abdominal closure, isotonic saline, beractant, Seprafilm, and combined agents were intraperitoneally administered. Adhesions were classified macroscopically with Canbaz Scoring System on postoperative day 10. Ceacum was resected for histopathological assessment.
  
  
  RESULTS
  Macroscopic adhesion scores were significantly lower in BG, SG, and COG than CG (p<0.05); (45%, 15%, 25%, and 15%; respectively). Histopathological assessment revealed a reduced inflammation and fibrosis score in the study groups than CG (p<0.05). In BG, adhesion development, inflammation and fibrosis scores were lower than SG; however, it was not statistically significant.
  
  
  CONCLUSIONS
  Intra-abdominal application of beractant is significantly effective for the prevention of adhesion formation with no adverse effect by covering the whole peritoneal mesothelium with excellent gliding properties in a rat model. The combination of both agents is also effective in reducing adhesion formation, however, not superior to single beractant application.
authors.affiliation: MD, Department of General Surgery, Adana Numune Training and Research Hospital, Adana, Turkey. Analysis of data, surgical procedures, manuscript preparation.
authors.forename: Ersoy
authors.initials: E
authors.lastname: Arslan
authors.affiliation: PhD, Associate Professor, Department of General Surgery, Adana Numune Training and Research Hospital, Adana, Turkey. Design of the study, critical revision.
authors.forename: Oktay
authors.initials: O
authors.lastname: Irkorucu
authors.affiliation: MD, Division of Gastroenterological Surgery, Department of General Surgery, Adana Numune Training and Research Hospital, Adana, Turkey. Surgical procedures, analysis of data, manuscript preparation.
authors.forename: Alper
authors.initials: A
authors.lastname: Sozutek
authors.affiliation: MD, Associate Professor, Department of General Surgery, Adana Numune Training and Research Hospital, Adana, Turkey. Acquisition of data, manuscript review.
authors.forename: Suleyman
authors.initials: S
authors.lastname: Cetinkunar
authors.affiliation: MD, Associate Professor, Division of Gastroenterological Surgery, Department of General Surgery, Adana Numune Training and Research Hospital, Adana, Turkey. Acquisition of data, manuscript review.
authors.forename: Enver
authors.initials: E
authors.lastname: Reyhan
authors.affiliation: MD, Department of General Surgery, Adana Numune Training and Research Hospital, Adana, Turkey. Acquisition of data, manuscript review.
authors.forename: Abit
authors.initials: A
authors.lastname: Yaman
authors.affiliation: PhD, Department of Pathology, Cukurova University Medical Faculty, Adana, Turkey. Histopathological examinations, manuscript review.
authors.forename: Figen
authors.initials: F
authors.lastname: Doran
mesh_terms: D000818:Animals; D001688:Biological Products / Q000494:pharmacology*; D002429:Cecal Diseases / Q000517:prevention & control*; D002432:Cecum / Q000187:drug effects* / Q000473:pathology / Q000601:surgery; D004359:Drug Therapy, Combination / Q000379:methods; D005260:Female; D005355:Fibrosis; D006820:Hyaluronic Acid / Q000494:pharmacology*; D007249:Inflammation / Q000473:pathology / Q000517:prevention & control; D023421:Models, Animal; D010537:Peritoneum / Q000187:drug effects / Q000473:pathology; D011182:Postoperative Care / Q000295:instrumentation; D011897:Random Allocation; D017208:Rats, Wistar; D000267:Tissue Adhesions / Q000473:pathology / Q000517:prevention & control
chemical_list: D001688:Biological Products; C118198:Seprafilm; D006820:Hyaluronic Acid; C072197:beractant