title: Occurrence of renal cell carcinoma and hematologic malignancies (predominantly lymphoid) in individuals and in families.
abstract: The relationship between renal cell cancer (RCC) and hematologic malignancy (HM) in the same individual has been reported for more than 20 years, and is noted in SEER database studies. Family histories suggest a familial association as well. This study evaluates the occurrence of renal cell cancer and hematologic malignancies in individual patients and families, and the occurrence of age-of-onset anticipation among generations. Family history data from our familial patient registry, including more than 700 pedigrees of familial hematologic malignancies, and 700 patients with renal cell cancer, were reviewed. Twenty-six patients with a personal history of both RCC and HM are reported. Seventy four patients with RCC are noted to have 95 family members with HM. Consistent with past reports, there was male predominance among the patients with both diseases (71 %), and among the RCC patients' relatives with HM (57 %). Also consistent was a predominance of lymphoid malignancies in those with both diseases (92 %) and in the HMs among family members of RCC patients (79 %). The majority (95 %) of HM relatives were first or second degree relatives of the patient with RCC. Thirty of 34 parent/child pairs demonstrated age of onset anticipation in which the child developed either disease at a younger age than the parent. The co-occurrence of RCC and HM in the same patient has been shown to be significantly greater than expected. Families also appear to have an increased association. The appearance of anticipation suggests that genetic factors may be significant in this association of RCC and HM.
authors.affiliation: Our Lady of Mercy Cancer Center, New York Medical College, 750 Kappock Street, # 511, Bronx, NY, 10463, USA. jpd4401@aol.com.|Cancer Research Foundation of New York, Chappaqua, NY, USA. jpd4401@aol.com.
authors.forename: Janice P
authors.initials: JP
authors.lastname: Dutcher
authors.affiliation: Our Lady of Mercy Cancer Center, New York Medical College, 750 Kappock Street, # 511, Bronx, NY, 10463, USA.|Cancer Research Foundation of New York, Chappaqua, NY, USA.
authors.forename: Peter H
authors.initials: PH
authors.lastname: Wiernik
authors.affiliation: Cancer Research Foundation of New York, Chappaqua, NY, USA.|Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Leticia
authors.initials: L
authors.lastname: Varella
authors.affiliation: Cancer Research Foundation of New York, Chappaqua, NY, USA.|Kadlec Regional Medical Center, Richland, WA, USA.
authors.forename: Rangaswamy
authors.initials: R
authors.lastname: Chintapatla
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000473:pathology; D005260:Female; D020022:Genetic Predisposition to Disease; D019337:Hematologic Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D006801:Humans; D015994:Incidence; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D035781:Siblings
keywords: Familial hematologic malignancies; Lymphoma; Renal cell cancer