title: Endometrial Cancer in Hospital Universiti Sains Malaysia.
abstract: BACKGROUND
  Endometrial cancer is the most common gynecological malignancy among females worldwide, approximately 320,000 women being diagnosed with the disease each year and 76,000 dying. To date, there is limited knowledge of endometrial cancer in Malaysia.
  
  
  OBJECTIVE
  To identify the epidemiological profile and prognostic factors of survival.
  
  
  METHODS
  A list of endometrial cancer patients in 2000-2011 was obtained from the hospital Record Department. Only cases confirmed by histopathology examination were included. We excluded those with incomplete medical records or referral cases. Simple and multiple Cox regression approaches were used for data analysis.
  
  
  RESULTS
  Only 108 cases were included with a mean (SD) age of 62.7 (12.3) years, with 87.0% Malay ethnicity. Grade of cancer was: 29.1% grade 1, 43.7% grade 2 and 27.2% grade 3. The majority of patients had non-endometrioid type (60.2%), with myometrial invasion (82.2%) and lymphovascular invasion (57.3%). The significant prognostic factors were age (HR 1.05; 95% CI: 1.02, 1.08, p=0.002) and having lymphovascular invasion (HR 2.15; 95% CI: 1.08, 4.29; p=0.030).
  
  
  CONCLUSIONS
  Endometrial cancer patients should be diagnosed earlier to reduce the risk of mortality. The public should be given education on the signs and symptoms of the disease.
authors.affiliation: Unit of Biostatistics and Research Methodology, School of Medical Sciences, Universiti Sains Malaysia, Malaysia E-mail : ctazrin@usm.my.
authors.forename: Wan Adnan
authors.initials: WA
authors.lastname: Wan-Nor-Asyikeen
authors.forename: Ab Hamid
authors.initials: AH
authors.lastname: Siti-Azrin
authors.forename: Nur Asyilla Che
authors.initials: NA
authors.lastname: Jalil
authors.forename: Nor Hayati
authors.initials: NH
authors.lastname: Othman
authors.forename: Anani Aila Mat
authors.initials: AA
authors.lastname: Zain
mesh_terms: D016889:Endometrial Neoplasms / Q000453:epidemiology* / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006785:Hospitals, University / Q000706:statistics & numerical data*; D006801:Humans; D008296:Malaysia / Q000453:epidemiology; D008875:Middle Aged; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D015995:Prevalence; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors