title: Reversal of Dabigatran with Idarucizumab.
abstract: BACKGROUND
  The use of novel oral anticoagulants such as dabigatran has been increasing over the last five years. Indicated for use in the prevention of thromboembolic complications from non-valvular atrial fibrillation and for the treatment and prevention of venous thromboembolic disease, dabigatran is increasingly encountered clinically. Lack of an efficacious reversal agent has been a challenge for increased clinical 10 adoption, and for management of patients with bleeding complications while taking dabigatran, or those requiring urgent procedures while taking dabigatran. Idarucizumab, a monoclonal antibody fragment, has recently been approved for use to reverse anticoagulation with dabigatran in patients with serious bleeding.
  
  
  METHODS
  Herein we discuss the development and early clinical data evaluating the use of idarucizumab for dabigatran reversal. Expert commentary: Idarucizumab has been shown to be an efficacious reversal agent for patients receiving dabigatran. The drug provides a novel and clinically useful agent for patients with significant bleeding while receiving dabigatran, or those needing urgent invasive procedures.
authors.affiliation: a Division of Cardiac Surgery, Alpert Medical School , Brown University , Providence , RI , USA.
authors.forename: Neel R
authors.initials: NR
authors.lastname: Sodha
authors.affiliation: a Division of Cardiac Surgery, Alpert Medical School , Brown University , Providence , RI , USA.
authors.forename: Frank W
authors.initials: FW
authors.lastname: Sellke
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D000925:Anticoagulants / Q000009:adverse effects / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000188:drug therapy; D001777:Blood Coagulation / Q000187:drug effects; D000069604:Dabigatran / Q000009:adverse effects*; D006470:Hemorrhage / Q000139:chemically induced / Q000188:drug therapy*; D006801:Humans; D013923:Thromboembolism / Q000188:drug therapy
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000925:Anticoagulants; C000594745:idarucizumab; D000069604:Dabigatran
keywords: Idarucizumab; anticoagulation; bleeding reversal; dabigatran; novel oral anticoagulant