title: Prediction of 5-year survival in advanced-stage ovarian cancer patients based on computed tomography peritoneal carcinomatosis index.
abstract: To evaluate whether the quantification of peritoneal metastases in advanced-stage ovarian cancer patients using the peritoneal carcinomatosis index, detected by CT (CT-PCI), correlates with the serum levels of tumor marker CA-125 and 5-year survival.
  
  
  
  The CT-PCI was determined in 82 patients with stage III or stage IV ovarian cancer using the Sugarbaker classification prior to cytoreductive surgery. Linear regression analysis was used to correlate CT-PCI and CA-125 levels. Correlation of presurgical CT-PCI, optimal surgical cytoreduction, and 5-year survival was established using binary logistic regression analysis. A score for prediction of 5-year survival probability was established using multivariate backwards binary logistic regression.
  
  
  
  Presurgical CT-PCI correlates significantly with presurgical CA-125 serum levels (r = 0.487, P < 0.001). Multivariate binary logistic regression suggested significantly improved 5-year survival with lower CT-PCI and lower ECOG performance scores.
  
  
  
  CT-PCI allows quantification of peritoneal disease in advanced-stage ovarian cancer patients, similar to CA-125. CT-PCI in combination with ECOG performance has the potential to help evaluate the 5-year survival probability.
authors.affiliation: Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA. diazgil.daniel@gmail.com.
authors.forename: Daniel
authors.identifier: 0000-0002-4179-5570
authors.initials: D
authors.lastname: Diaz-Gil
authors.affiliation: Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.
authors.forename: Florian J
authors.initials: FJ
authors.lastname: Fintelmann
authors.affiliation: Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.
authors.forename: Sanaz
authors.initials: S
authors.lastname: Molaei
authors.affiliation: Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.
authors.forename: Azadeh
authors.initials: A
authors.lastname: Elmi
authors.affiliation: Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.
authors.forename: Sandeep S
authors.initials: SS
authors.lastname: Hedgire
authors.affiliation: Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.
authors.forename: Mukesh G
authors.initials: MG
authors.lastname: Harisinghani
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D018394:CA-125 Antigen / Q000097:blood; D003287:Contrast Media; D065426:Cytoreduction Surgical Procedures; D005260:Female; D006801:Humans; D007479:Iopamidol / Q000031:analogs & derivatives; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality* / Q000473:pathology* / Q000601:surgery; D010534:Peritoneal Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality* / Q000556:secondary* / Q000601:surgery; D011379:Prognosis; D015996:Survival Rate; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D003287:Contrast Media; C057937:iomeprol; D007479:Iopamidol
keywords: CA-125 antigen; Computed tomography; Neoadjuvant therapy; Ovarian cancer; Peritoneal disease; Prognosis