title: Early Risk Factors of Moderate/Severe Hepatotoxicity After Suicide Attempts With Acetaminophen in 11- to 15-Year-Old Children.
abstract: Objective. To characterize early risk factors of moderate/severe hepatotoxicity in a pediatric population with acetaminophen overdose, due to suicide attempt, admitted to a general secondary-level pediatric department. Methods. A retrospective case study of 107 patients, 11 to 15 years old. Results. There was a highly significant relationship between the number of episodes of prehospital vomiting and several elevated hepatologically relevant biochemical parameters, for example, maximum aspartate aminotransferase (P = .0001). The duration of the latency time before initiation of N-acetylcysteine treatment was significantly related to the elevation of several hepatologically relevant biochemical parameters (eg, maximum γ-glutamyl transferase; P = .0001). Patients suffering from illness prior to their suicide attempt had significantly greater elevations of their hepatologically relevant biochemical parameters, for example, maximum alanine aminotransferase (P = .01) levels than healthy patients. Conclusion. By use of risk factors, it is possible to identify pediatric patients at increased risk of moderate/severe hepatotoxicity at an early stage of admission.
authors.affiliation: Nordsjællands Hospital, Hillerød, Denmark.
authors.forename: Rikke Lindgaard
authors.initials: RL
authors.lastname: Hedeland
authors.affiliation: Rigshospitalet, Copenhagen, Denmark.
authors.forename: Vibeke Brix
authors.initials: VB
authors.lastname: Christensen
authors.affiliation: Rigshospitalet, Copenhagen, Denmark.
authors.forename: Marianne Hørby
authors.initials: MH
authors.lastname: Jørgensen
authors.affiliation: Nordsjællands Hospital, Hillerød, Denmark.
authors.forename: Grete
authors.initials: G
authors.lastname: Teilmann
authors.affiliation: Nordsjællands Hospital, Hillerød, Denmark.
authors.forename: Amne
authors.initials: A
authors.lastname: Iskandar
authors.affiliation: Nordsjællands Hospital, Hillerød, Denmark.
authors.forename: Jesper
authors.initials: J
authors.lastname: Andersen
keywords: acetaminophen; early risk factors of hepatotoxicity; hepatotoxicity; suicide attempt