title: L-Arginine Modulates Glucose and Lipid Metabolism in Obesity and Diabetes.
abstract: Type 2 diabetes has become a global public health problem affecting approximately 380 million people throughout the world. It can cause many complications and lead to greater mortality. At present, there is no available medicine for effectively preventing diabetes. L-arginine, a functional amino acid, the precursor of nitric oxide, plays a crucial role in maintenance, reproduction, growth, anti-aging and immunity for animals. Growing clinical evidence indicates that dietary L-arginine supplementation can reduce obesity, decrease arterial blood pressure, resist oxidation and normalize endothelial dysfunction to bring about remission of type 2 diabetes. The potential molecular mechanism may play a role in modulating glucose homeostasis, promoting lipolysis, maintaining hormone levels, ameliorating insulin resistance, and fetal programing in early stages. The possible signaling pathway of the beneficial effects of L-arginine likely involves L-arginine-nitric oxide pathway through which cell signal protein can be activated. Accumulating studies have indicated that L-arginine may have potential to prevent and/or relieve type 2 diabetes via restoring insulin sensitivity in vivo.
authors.affiliation: State Key Lab of Animal Nutrition, China Agricultural University, Beijing 100193. China.
authors.forename: Shengdi
authors.initials: S
authors.lastname: Hu
authors.affiliation: State Key Lab of Animal Nutrition, China Agricultural University, Beijing 100193. China.
authors.forename: Meng
authors.initials: M
authors.lastname: Han
authors.affiliation: School of Medicine, University of Central Florida, Orlando, Florida, FL. United States.
authors.forename: Arash
authors.initials: A
authors.lastname: Rezaei
authors.affiliation: State Key Lab of Animal Nutrition, China Agricultural University, Beijing 100193. China.
authors.forename: Defa
authors.initials: D
authors.lastname: Li
authors.affiliation: State Key Lab of Animal Nutrition, China Agricultural University, Beijing 100193. China.
authors.forename: Guoyao
authors.initials: G
authors.lastname: Wu
authors.affiliation: State Key Lab of Animal Nutrition, China Agricultural University, Beijing, 100193. China.
authors.forename: Xi
authors.initials: X
authors.lastname: Ma
mesh_terms: D000818:Animals; D001120:Arginine / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007333:Insulin Resistance; D050356:Lipid Metabolism; D009569:Nitric Oxide / Q000378:metabolism; D009765:Obesity / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D009569:Nitric Oxide; D001120:Arginine; D005947:Glucose
keywords: L-arginine; diabetes; glucose/lipid metabolism; insulin-resistance; nitric oxide