title: Iridoid Esters from Tabebuia avellanedae and Their In Vitro Anti-inflammatory Activities.
abstract: A phytochemical investigation of the inner bark ofTabebuia avellanedaeLorentz ex Griseb was carried out by various chromatographic techniques, resulting in the isolation and characterization of eight new iridoid esters, namely Avelladoids A-H (1-8). Their chemical structures were elucidated on the basis of extensive spectroscopic analyses, especially 2D NMR experiments and HRMS data. The anti-inflammatory effects of1-8were determined on an LPS-stimulated RAW 264.7 cell line. Among them, compounds1, 2, and3exhibited anti-inflammatory activities by inhibition of NO and PGE2production in a dose-dependent manner, without altering cell viability.
authors.affiliation: College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa City, Japan.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa City, Japan.
authors.forename: Isao
authors.initials: I
authors.lastname: Hasegawa
authors.affiliation: College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa City, Japan.
authors.forename: Tomihisa
authors.initials: T
authors.lastname: Ohta
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D053898:Biosynthetic Pathways; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004952:Esters / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000067996:RAW 264.7 Cells; D029663:Tabebuia / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D004952:Esters; D039823:Iridoids; D010936:Plant Extracts; D009569:Nitric Oxide