title: Effect of blending HA-g-PLLA on xanthohumol-loaded PLGA fiber membrane.
abstract: Electropsun poly (lactide-co-glycolide) (PLGA) fiber membrane loaded xanthohumol (XN) has been developed using a co-solvent system of chloroform and dimethylformamide. To enhance its biological functionality as bone tissue engineering scaffolds, 5wt% hydroxyapatite grafted poly (l-lactic acid) (HA-g-PLLA) is blended into the spinning solution. The purpose of the present work is to disclose the effect of blending HA-g-PLLA on the corresponding properties of the medicated fiber membrane including morphology, thermodynamics, wettability, drug release, mechanics as well as cytotoxicity. XN and HA-g-PLLA can be well blended with PLGA to make fibers. Blending HA-g-PLLA not only turns amorphous XN/PLGA fiber membrane into crystal structure, but also changes the membranous wettability. Various medicated membranes exhibit the sustained release profiles. Drug release rate of the ternary membrane with HA-g-PLLA is slower compared to the binary XN/PLGA, and for the ternary membrane, the drug release accelerates with increasing XN content. A model is proposed to account for the drug release process. Tensile testing shows that at 10% of XN, the comprehensive mechanics of the ternary is preferable to the binary. At the same time, these fiber membranes are no cytotoxicity.
authors.affiliation: School of Chemical Engineering, Changchun University of Technology, Changchun 130012, PR China.
authors.forename: Tiankui
authors.initials: T
authors.lastname: Qiao
authors.affiliation: School of Chemical Engineering, Changchun University of Technology, Changchun 130012, PR China.
authors.forename: Suchen
authors.initials: S
authors.lastname: Jiang
authors.affiliation: School of Chemical Engineering, Changchun University of Technology, Changchun 130012, PR China.
authors.forename: Ping
authors.initials: P
authors.lastname: Song
authors.affiliation: School of Chemical Engineering, Changchun University of Technology, Changchun 130012, PR China; Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China. Electronic address: jlsongx@163.com.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Song
authors.affiliation: School of Chemical Engineering, Changchun University of Technology, Changchun 130012, PR China.
authors.forename: Qimin
authors.initials: Q
authors.lastname: Liu
authors.affiliation: School of Chemical Engineering, Changchun University of Technology, Changchun 130012, PR China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Wang
authors.affiliation: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China.
authors.forename: Xuesi
authors.initials: X
authors.lastname: Chen
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D065546:Drug Liberation; D017886:Durapatite / Q000737:chemistry*; D005419:Flavonoids / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D019344:Lactic Acid / Q000737:chemistry*; D008422:Materials Testing; D008567:Membranes, Artificial; D051379:Mice; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects*; D011091:Polyesters / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011427:Propiophenones / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D013499:Surface Properties; D023822:Tissue Engineering; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; D005419:Flavonoids; D008567:Membranes, Artificial; D011091:Polyesters; D011427:Propiophenones; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; C033616:poly(lactide); D017886:Durapatite; C104536:xanthohumol
keywords: Electropun fiber; HA-g-PLLA; PLGA; Properties; Xanthohumol