title: The role of transient receptor potential channels in hypertension and metabolic vascular damage.
abstract: What is the topic of this review? Transient receptor potential (TRP) channels are highly implicated in the pathogenesis of hypertension and the regulation of metabolism. What advances does it highlight? Dysfunction of TRP channels leads to hypertension and metabolic disorders. Elucidating the role of TRP channels in hypertension and metabolic vascular damage would facilitate the design of novel target therapeutics for these intractable diseases. Intracellular Ca2+homeostasis is critical for vascular function and the regulation of metabolism. Metabolic disorders are major risk factors for hypertension. A family of transient receptor potential (TRP) channels plays an important role in the regulation of cellular calcium signalling and cardiometabolic function. Emerging evidence indicates that TRP channels are highly implicated in the pathogenesis of hypertension and metabolic disorders. Dysfunction of TRP channels leads to hypertension and metabolic dysfunction. Activation of certain subtypes of TRP channels could attenuate metabolic vascular damage and alleviate hypertension. Therefore, elucidating the role of TRP channels in the physiological state and in cardiometabolic diseases will facilitate the design of novel targeted therapeutics for these intractable diseases.
authors.affiliation: Center for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing, 400042, China. zhuzm@yahoo.com.
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: Center for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing, 400042, China.
authors.forename: Shiqiang
authors.initials: S
authors.lastname: Xiong
authors.affiliation: Center for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing, 400042, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
mesh_terms: D000818:Animals; D020013:Calcium Signaling / Q000502:physiology; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D008659:Metabolic Diseases / Q000378:metabolism*; D050051:Transient Receptor Potential Channels / Q000378:metabolism*
chemical_list: D050051:Transient Receptor Potential Channels
keywords: hypertension; metabolism; transient receptor potential channels