title: [Association of gene polymorphisms with the susceptibility of schizophrenia in Han Chinese population].
abstract: OBJECTIVE
  To investigate the potential association of carbonic anhydrase I (CA1) anterior pharynx-defective 1A ( APH1A), neurodevelopment protein 1-like 1 (NDEL1) and serine racemase (SRR) gene polymorphisms with the susceptibility of schizophrenia (SZ).
  
  
  METHODS
  A case-control study was performed to identify polymorphisms of the CA1, APH1A, NDEL1 and SRR gene that may confer susceptibility to SZ in the Han Chinese population. Five single nucleotide polymorphisms (SNPs) were genotyped in 516 paranoid SZ patients and 516 control subjects by real time quantitative polymerase chain reaction. The association between genotypes and positive and negative symptoms scale was also explored.
  
  
  RESULTS
  No significant differences in genotype or allele frequencies of five SNPs were observed between schizophrenic patients and healthy controls (P = 0.163, 0.322, 0.494, 0.338, 0.545; 0.259, 0.149, 0.417, 0.527, 0.720; respectively). However, the frequency of CA haplotypes in SZ group was higher than control group (P = 0.041). The scores of depression/anxiety, positive and excited/hostile factors in SZ patients with genotype of rs2298161 (AG), rs4523957 (CC) and rs8081273 (GG) were higher than other genotypes (P = 0.008, 0.001, 0.000, respectively).
  
  
  CONCLUSIONS
  These data suggests that the CA1, APH1A, NDEL1 and SRR gene may not be association with susceptibility to SZ in the Han Chinese population. However, the haplotype of CA may be the susceptible factor of SZ. Rs2298161, rs4523957 and rs8081273 may be associated with some phenotypes of SZ.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Yu
authors.forename: Haisan
authors.initials: H
authors.lastname: Zhang
authors.forename: Yongfeng
authors.initials: Y
authors.lastname: Yang
authors.forename: Wenqiang
authors.initials: W
authors.lastname: Li
authors.forename: Hongxing
authors.initials: H
authors.lastname: Zhang
authors.forename: Ge
authors.initials: G
authors.lastname: Yang
authors.forename: Luxian
authors.initials: L
authors.lastname: Lü
mesh_terms: D044466:Asian People; D024401:Carbonic Anhydrase I / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D010450:Endopeptidases; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics; D010447:Peptide Hydrolases / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D019998:Racemases and Epimerases / Q000235:genetics; D012559:Schizophrenia / Q000235:genetics*; D000099300:Serine Racemase
chemical_list: D024401:Carbonic Anhydrase I; D002352:Carrier Proteins; D010450:Endopeptidases; D008565:Membrane Proteins; D010447:Peptide Hydrolases; D019998:Racemases and Epimerases; D000099300:Serine Racemase; C421108:NDEL1 protein, human; C475154:APH1A protein, human