title: Robotic Radiosurgery for the Treatment of Intramedullary Spinal Cord Metastases: A Case Report and Literature Review.
abstract: Modern technologies allow the delivery of high radiation doses to intramedullary spinal cord metastases while lowering the dose to the neighboring organs at risk. Whether this dosimetric advantage translates into clinical benefit is not well known. This study evaluates the acute and late toxicity outcomes in a patient treated with robotic radiosurgery for an intramedullary spinal cord metastasis. A 50-year-old woman diagnosed in May 2006 with invasive ductal carcinoma of the right breast T2N3M1 (two liver metastases) received chemotherapy with a complete response. Subsequently, she underwent adjuvant whole-breast radiotherapy, along with tamoxifen. After several distant relapses, treated mainly with systemic therapy, the patient developed an intramedullary lesion at the C3-C4 level and was referred to our CyberKnife unit for assessment. A total dose of 14 Gy prescribed to the 74% isodose line was administered to the intramedullary lesion in one fraction. One hundred and two treatment beams were used covering 95.63% of the target volume. The mean dose was 15.93 Gy and the maximum dose, 18.92 Gy. Maximum dose to the spinal cord was 13.96 Gy, V12 ~ 0.13 cc and V8 ~ 0.43 cc. Three months after treatment, magnetic resonance imaging showed a reduction in size and enhancement of the intramedullary lesion with no associated toxicity. During this period, the patient showed a good performance status without neurological deficits. Currently, with a follow-up of 37 months, the patient has the ability to perform activities of daily life. Intramedullary spinal cord metastases is a rare and aggressive disease, often treatment-refractory. Our case demonstrates that radiation therapy delivery with robotic radiosurgery allows the achievement of a high local control without adding toxicity.
authors.affiliation: Robotic Radiosurgery Unit, Imoncology.
authors.forename: Rafael
authors.initials: R
authors.lastname: Garcia
authors.affiliation: Radiosurgery, Imoncology.
authors.forename: Kita
authors.initials: K
authors.lastname: Sallabanda
authors.affiliation: Radiation Physics, Imoncology.
authors.forename: Iciar
authors.initials: I
authors.lastname: Santa-Olalla
authors.affiliation: Radiation Oncology, Virgen del Rocío University Hospital.
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Lopez Guerra
authors.affiliation: Master in Advanced Technological Applications in Radiation Oncology, University of Murcia and Imoncology Foundation.
authors.forename: Lijia
authors.initials: L
authors.lastname: Avilés
authors.affiliation: Radiation Oncology, Hospital Universitario Puerta de Hierro.
authors.forename: Morena
authors.initials: M
authors.lastname: Sallabanda
authors.affiliation: Radiation Oncology, Institut de cancérologie Gustave Roussy.
authors.forename: Eleonor
authors.initials: E
authors.lastname: Rivin
authors.affiliation: Radiosurgery, Imoncology.
authors.forename: José
authors.initials: J
authors.lastname: Samblás
keywords: intramedullary spinal cord metastases; radiosurgery; robotic radiosurgery