title: Oxidative Stress Relevance in the Pathogenesis of the Rheumatoid Arthritis: A Systematic Review.
abstract: Rheumatoid arthritis (RA) is an autoimmune inflammatory disease whose pathogenic mechanisms remain to be elucidated. The oxidative stress and antioxidants play an important role in the disease process of RA. The study of oxidants and antioxidants biomarkers in RA patients could improve our understanding of disease pathogenesis; likely determining the oxidative stress levels in these patients could prove helpful in assessing disease activity and might also have prognostic implications. To date, the usefulness of oxidative stress biomarkers in RA patients is unclear and the evidence supporting them is heterogeneous. In order to resume and update the information in the status of oxidants and antioxidants and their connection as biomarkers in RA, we performed a systematic literature search in the PubMed database, including clinical trials published in the last five years using the word combination "rheumatoid arthritis oxidative stress". In conclusion, this review supports the fact that the oxidative stress is an active process in RA pathogenesis interrelated to other better known pathogenic elements. However, some controversial results preclude a definite conclusion.
authors.affiliation: Facultad de Ciencias de la Cultura Física, Universidad Autónoma de Chihuahua, Circuito No. 1, Nuevo Campus Universitario, Apartado Postal 1552, 31240 Chihuahua, CHIH, Mexico; Facultad de Medicina y Ciencias Biomédicas, Universidad Autónoma de Chihuahua, Circuito No. 1, Nuevo Campus Universitario, Apartado Postal 1552, 31240 Chihuahua, CHIH, Mexico.
authors.forename: Celia María
authors.initials: CM
authors.lastname: Quiñonez-Flores
authors.affiliation: Facultad de Ciencias de la Cultura Física, Universidad Autónoma de Chihuahua, Circuito No. 1, Nuevo Campus Universitario, Apartado Postal 1552, 31240 Chihuahua, CHIH, Mexico; Facultad de Medicina y Ciencias Biomédicas, Universidad Autónoma de Chihuahua, Circuito No. 1, Nuevo Campus Universitario, Apartado Postal 1552, 31240 Chihuahua, CHIH, Mexico.
authors.forename: Susana Aideé
authors.initials: SA
authors.lastname: González-Chávez
authors.affiliation: Facultad de Medicina y Ciencias Biomédicas, Universidad Autónoma de Chihuahua, Circuito No. 1, Nuevo Campus Universitario, Apartado Postal 1552, 31240 Chihuahua, CHIH, Mexico.
authors.forename: Danyella
authors.initials: D
authors.lastname: Del Río Nájera
authors.affiliation: Facultad de Medicina y Ciencias Biomédicas, Universidad Autónoma de Chihuahua, Circuito No. 1, Nuevo Campus Universitario, Apartado Postal 1552, 31240 Chihuahua, CHIH, Mexico.
authors.forename: César
authors.initials: C
authors.lastname: Pacheco-Tena
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000453:epidemiology / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016877:Oxidants / Q000097:blood* / Q000276:immunology*; D018384:Oxidative Stress / Q000276:immunology; D015995:Prevalence; D017382:Reactive Oxygen Species / Q000097:blood / Q000276:immunology*; D015203:Reproducibility of Results; D012307:Risk Factors; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D015415:Biomarkers; D016877:Oxidants; D017382:Reactive Oxygen Species