title: Distribution of Serum Uric Acid in Black Africans and Its Association With Cardiovascular Risk Factors.
abstract: Hyperuricemia is associated with cardiovascular disease and its prevalence is unknown in black Africans. This study reports hyperuricemia distribution and its association with cardiovascular risk factors in a selected Angolan population. A cross-sectional study in 585 black Africans was performed. Hyperuricemia was defined as uric acid >7.0 mg/dL in men or >5.7 mg/dL in women. Overall prevalence was 25%. Hyperuricemia was associated with hypertension (odds ratio [OR], 2.20; confidence interval [CI], 95% 1.41-3.47), high waist circumference (OR, 1.67; CI, 95% 1.05-2.65), and metabolic syndrome (OR, 1.66; CI, 95% 1.07-2.57). Compared to those with uric acid levels in the first quartile, individuals in the fourth quartile showed higher body mass index, waist circumference, systolic blood pressure, and plasma levels of creatinine and triglycerides. Hypertension, high waist circumference, and metabolic syndrome were the major cardiovascular risk factors associated with hyperuricemia.
authors.affiliation: Department of Physiological Sciences, Federal University of Espírito Santo (UFES), Vitoria, Espírito Santo, Brazil.
authors.forename: Stephanie R
authors.initials: SR
authors.lastname: Moulin
authors.affiliation: Department of Physiological Sciences, Federal University of Espírito Santo (UFES), Vitoria, Espírito Santo, Brazil.|Department of Pathophysiology, Montes Claros State University (UNIMONTES), Montes Claros, MG, Brazil.
authors.forename: Marcelo P
authors.initials: MP
authors.lastname: Baldo
authors.affiliation: Department of Physiological Sciences, Federal University of Espírito Santo (UFES), Vitoria, Espírito Santo, Brazil.
authors.forename: Juliana B
authors.initials: JB
authors.lastname: Souza
authors.affiliation: Department of Internal Medicine, Federal University of Espírito Santo (UFES), Vitoria, Espírito Santo, Brazil.
authors.forename: Weverton M
authors.initials: WM
authors.lastname: Luchi
authors.affiliation: Department of Physiological Sciences, Medical School of the Agostinho Neto University (UAN), Luanda, Angola.
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Capingana
authors.affiliation: Department of Physiological Sciences, Medical School of the Agostinho Neto University (UAN), Luanda, Angola.
authors.forename: Pedro
authors.initials: P
authors.lastname: Magalhães
authors.affiliation: Department of Physiological Sciences, Federal University of Espírito Santo (UFES), Vitoria, Espírito Santo, Brazil.
authors.forename: José G
authors.initials: JG
authors.lastname: Mill
mesh_terms: D000328:Adult; D000368:Aged; D000810:Angola / Q000453:epidemiology; D044383:Black People / Q000706:statistics & numerical data; D002318:Cardiovascular Diseases / Q000209:etiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology*; D033461:Hyperuricemia / Q000097:blood / Q000453:epidemiology*; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D008875:Middle Aged; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*; D055105:Waist Circumference; D055815:Young Adult
chemical_list: D014527:Uric Acid