title: Standardized Boesenbergia pandurata Extract Stimulates Exercise Endurance Through Increasing Mitochondrial Biogenesis.
abstract: In the present study, the effect of standardized Boesenbergia pandurata (Roxb.) Schltr. (fingerroot) ethanol extract on exercise endurance was investigated in L6 rat skeletal muscle cells and C57BL/6J mice. Standardized B. pandurata ethanol extract (BPE) increased mitochondrial mass and stimulated the mRNA expression of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) in vitro. BPE also elevated the mRNA expression of key factors of mitochondrial biogenesis and function, which are activated by PGC-1α, such as estrogen-related receptor α (ERRα), nuclear respiratory factor 1 (NRF-1), and mitochondrial transcription factor A (Tfam). In animal models, both normal and high-fat diet (HFD)-induced obese mice treated with BPE ran much longer than their respective controls. In addition, BPE increased the protein expressions of phosphorylated AMP-activated protein kinase (AMPK), sirtuin 1 (SIRT1), PGC-1α, and peroxisome proliferator-activated receptor delta (PPARδ), which are stimulated by exercise. These results indicate that B. pandurata could be a potential nutraceutical candidate for enhancing exercise endurance based on its mitochondrial biogenesis and exercise-mimicking effects.
authors.affiliation: 1 Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University , Seoul, Korea.
authors.forename: Taeyoon
authors.initials: T
authors.lastname: Kim
authors.affiliation: 1 Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University , Seoul, Korea.
authors.forename: Mi-Bo
authors.initials: MB
authors.lastname: Kim
authors.affiliation: 1 Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University , Seoul, Korea.
authors.forename: Changhee
authors.initials: C
authors.lastname: Kim
authors.affiliation: 2 Division of Integrative Biosciences and Biotechnology, Department of Life Sciences, POSTECH , Pohang, Korea.
authors.forename: Hoe-Yune
authors.initials: HY
authors.lastname: Jung
authors.affiliation: 1 Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University , Seoul, Korea.
authors.forename: Jae-Kwan
authors.initials: JK
authors.lastname: Hwang
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000235:genetics; D000818:Animals; D002460:Cell Line; D059305:Diet, High-Fat; D015870:Gene Expression / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D018485:Muscle Fibers, Skeletal; D001678:Organelle Biogenesis; D047494:PPAR delta / Q000235:genetics; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / Q000235:genetics / Q000502:physiology; D010807:Physical Endurance / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D056564:Sirtuin 1 / Q000235:genetics; D030521:Zingiberaceae / Q000737:chemistry*
chemical_list: D047494:PPAR delta; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D010936:Plant Extracts; D012333:RNA, Messenger; D055372:AMP-Activated Protein Kinases; D056564:Sirtuin 1
keywords: Boesenbergia pandurata (Roxb.) Schltr; PGC-1α; exercise endurance; fiber-type switching; mitochondrial biogenesis