title: [New side effects of proton pump inhibitors; time for reflection?].
abstract: Large population studies published recently have revealed additional risks of chronic use of proton pump inhibitors (PPIs). Dementia and renal failure were reported as long-term follow-up side effects of chronic use, in addition to the previously known increased risk for various infections, osteoporosis and metabolic disturbances. In the light of ongoing over-prescription of PPIs, this should lead to reconsideration of individual indications.
authors.affiliation: UMC Utrecht, Julius Centrum voor Gezondheidswetenschappen en Eerstelijns Geneeskunde, afd. Huisartsgeneeskunde, Utrecht.
authors.forename: N J
authors.initials: NJ
authors.lastname: de Wit
authors.forename: M E
authors.initials: ME
authors.lastname: Numans
mesh_terms: D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D054328:Proton Pump Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D054328:Proton Pump Inhibitors