title: Electrospun silk fibroin mat enhances tendon-bone healing in a rabbit extra-articular model.
abstract: OBJECTIVE
  To investigate whether electrospun silk fibroin (SF) mat wrapping could enhance tendon-bone healing of soft tissue graft.
  
  
  RESULTS
  Rabbit bone marrow-derived mesenchymal stem cells proliferated well on electrospun SF mat. The autologous Achilles tendon wrapped with electrospun SF mat was transplanted into the bone tunnel (experimental group) in a rabbit extra-articular model, while the unwrapped tendon was transplanted as control group. The electrospun SF mat wrapping could enhance tendon-bone healing of autologous tendon evaluated by micro-computed tomography scanning, histological examination and mechanical testing. At 6 and 12 weeks post-operatively, the failure loads of experimental group were both significantly higher than those of control group (40.5 ± 6.3 vs. 31.8 ± 4.6 N, P = 0.039 at 6 weeks; 67.1 ± 9. vs. 52.2 ± 4.7 N, P = 0.012 at 12 weeks).
  
  
  CONCLUSIONS
  The electrospun SF mat wrapping could enhance tendon-bone healing of soft tissue graft.
authors.affiliation: Department of Sports Medicine, Huashan Hospital, Fudan University, No. 12 Middle Wulumuqi Road, 200040, Shanghai, People's Republic of China.
authors.forename: Yunlong
authors.initials: Y
authors.lastname: Zhi
authors.affiliation: State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science and Laboratory of Advanced Materials, Fudan University, Shanghai, People's Republic of China.
authors.forename: Wen
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Sports Medicine, Huashan Hospital, Fudan University, No. 12 Middle Wulumuqi Road, 200040, Shanghai, People's Republic of China.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Sports Medicine, Huashan Hospital, Fudan University, No. 12 Middle Wulumuqi Road, 200040, Shanghai, People's Republic of China.
authors.forename: Jia
authors.initials: J
authors.lastname: Jiang
authors.affiliation: Department of Sports Medicine, Huashan Hospital, Fudan University, No. 12 Middle Wulumuqi Road, 200040, Shanghai, People's Republic of China. chenshiyifudan@sina.com.
authors.forename: Shiyi
authors.initials: S
authors.lastname: Chen
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000187:drug effects / Q000293:injuries*; D049109:Cell Proliferation; D002478:Cells, Cultured; D004195:Disease Models, Animal; D005349:Fibroins / Q000494:pharmacology*; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D011817:Rabbits; D013708:Tendon Injuries / Q000628:therapy*; D014945:Wound Healing / Q000187:drug effects*; D055114:X-Ray Microtomography
chemical_list: D005349:Fibroins
keywords: Anterior cruciate ligament; Electrospinning; Silk fibroin; Tendon-bone healing