title: DNA Damage and Aging Around the Clock.
abstract: The hematopoietic system undergoes many changes during aging, but the causes and molecular mechanisms behind these changes are not well understood. Wang et al. have recently implicated a circadian rhythm gene, Per2, as playing a role in the DNA damage response and in the expression of lymphoid genes in aged hematopoietic stem cells.
authors.affiliation: Program in Cellular and Molecular Medicine, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
authors.forename: Paula
authors.initials: P
authors.lastname: Gutierrez-Martinez
authors.affiliation: Program in Cellular and Molecular Medicine, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA; Harvard Stem Cell Institute, Cambridge, MA, USA.
authors.forename: Derrick J
authors.initials: DJ
authors.lastname: Rossi
authors.affiliation: Program in Cellular and Molecular Medicine, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. Electronic address: Isabel.Beerman@childrens.harvard.edu.
authors.forename: Isabel
authors.initials: I
authors.lastname: Beerman
mesh_terms: D000375:Aging; D000818:Animals; D002940:Circadian Rhythm; D004249:DNA Damage; D005786:Gene Expression Regulation; D006410:Hematopoiesis; D006801:Humans; D056950:Period Circadian Proteins / Q000235:genetics
chemical_list: C513312:Per2 protein, mouse; D056950:Period Circadian Proteins