title: Outcomes of infants with abdominal wall defects over 18years.
abstract: OBJECTIVE
  Infants with abdominal wall defects (AWD) are at risk of poor outcomes including prolonged hospitalization, infections and mortality. Our objective was to describe and compare the outcomes of infants admitted with gastroschisis and omphalocele over 18years.
  
  
  METHODS
  Population-based study of clinical data and outcomes of live-born infants with AWD admitted to all tertiary-level neonatal intensive care units in New South Wales and Australian Capital Territory from 1992 to 2009.
  
  
  RESULTS
  There were 502 infants with AWD - 336 gastroschisis, 166 omphalocele. Infants with gastroschisis required a longer duration of total parenteral nutrition (19 vs 4days, p<0.05), longer hospitalization (28 vs 15days, p<0.05) and had a higher rate of systemic infection [23.5% vs 13.3%, OR 1.77 (1.15-2.74), p<0.05] compared to infants with omphalocele. Overall, omphalocele infants had higher mortality rate compared to gastroschisis infants [OR 2.77 (1.53, 5.04), p<0.05]. Gastroschisis mortality rates increased from epoch 1 to epoch 3 (4.2% to 8.8%).
  
  
  CONCLUSIONS
  Compared to infants with omphalocele, infants with gastroschisis required significantly longer hospitalization and parenteral nutrition with higher rates of infection. Infants with omphalocele had higher overall mortality rates. However, there has been an increase in the gastroschisis mortality rates but the cause for this is unclear.
authors.affiliation: Department of Newborn Care, Royal Hospital for Women, Randwick, NSW, Australia; Department of Neonatology, KK Women's and Children's Hospital, Singapore. Electronic address: kong.juin.yee@kkh.com.sg.
authors.forename: Juin Yee
authors.initials: JY
authors.lastname: Kong
authors.affiliation: Department of Newborn Care, Royal Hospital for Women, Randwick, NSW, Australia; Department of Neonatology, KK Women's and Children's Hospital, Singapore.
authors.forename: Kee Thai
authors.initials: KT
authors.lastname: Yeo
authors.affiliation: Department of Neonatology, Centenary Hospital for Women and Children, Garran, ACT, Australia; School of Clinical Medicine, Australian National University, Woden, ACT, Australia.
authors.forename: Mohamed E
authors.initials: ME
authors.lastname: Abdel-Latif
authors.affiliation: Neonatal Intensive Care Units' Data Collection, NSW Pregnancy and Newborn Services Network, Westmead, NSW, Australia.
authors.forename: Barbara
authors.initials: B
authors.lastname: Bajuk
authors.affiliation: The Children's Hospital at Westmead, The University of Sydney, NSW, Australia;; School of Women's and Children's Health, University of New South Wales, Randwick, NSW, Australia;
authors.forename: Andrew J A
authors.initials: AJ
authors.lastname: Holland
authors.affiliation: School of Women's and Children's Health, University of New South Wales, Randwick, NSW, Australia;; Department of Pediatric Surgery, Sydney Children's Hospital, Randwick, NSW, Australia.
authors.forename: Susan
authors.initials: S
authors.lastname: Adams
authors.affiliation: School of Women's and Children's Health, University of New South Wales, Randwick, NSW, Australia;; Department of Pediatric Surgery, Sydney Children's Hospital, Randwick, NSW, Australia.
authors.forename: Ashish
authors.initials: A
authors.lastname: Jiwane
authors.affiliation: The Children's Hospital at Westmead, The University of Sydney, NSW, Australia;
authors.forename: Sandra
authors.initials: S
authors.lastname: Heck
authors.affiliation: Department of Newborn Care, Royal Hospital for Women, Randwick, NSW, Australia.
authors.forename: Michael
authors.initials: M
authors.lastname: Yeong
authors.affiliation: Department of Newborn Care, Royal Hospital for Women, Randwick, NSW, Australia; School of Women's and Children's Health, University of New South Wales, Randwick, NSW, Australia;
authors.forename: Kei
authors.initials: K
authors.lastname: Lui
authors.affiliation: Department of Newborn Care, Royal Hospital for Women, Randwick, NSW, Australia; School of Women's and Children's Health, University of New South Wales, Randwick, NSW, Australia;
authors.forename: Ju Lee
authors.initials: JL
authors.lastname: Oei
mesh_terms: D034861:Abdominal Wall; D005260:Female; D005544:Forecasting; D020139:Gastroschisis / Q000453:epidemiology* / Q000601:surgery*; D006554:Hernia, Umbilical / Q000453:epidemiology* / Q000601:surgery*; D006801:Humans; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D008297:Male; D009017:Morbidity / Q000639:trends; D009517:New South Wales; D015996:Survival Rate / Q000639:trends
keywords: Abdominal wall defect; Gastroschisis; Mortality; Neonate; Omphalocele; Outcomes