title: TMPRSS4 as an emerging potential poor prognostic factor for solid tumors: A systematic review and meta-analysis.
abstract: Recent studies have investigated the potential prognostic value of the transmembrane protease serine 4 (TMPRSS4) in various solid tumors. Yet, the results are inconclusive. Here, we performed this meta-analysis to clarify this issue. Relevant articles were identified by searching PubMed, Web of Science and Embase databases. The primary outcome endpoints were patients' overall survival (OS) and time to tumor progression (TTP). Twelve studies involving 1,955 participants were included. We showed that high TMPRSS4 expression in tumor tissues was significantly associated with patients' poor OS (pooled HR = 2.981, 95% CI = 2.296-3.869, P < 0.001) and short TTP (pooled HR = 2.456, 95% CI = 1.744-3.458, P < 0.001). A subgroup analysis revealed that the association between TMPRSS4 and the outcome endpoints (OS or TTP) was also significant within China region. We conclude that TMPRSS4 overexpression in solid tumors is associated with patients' poor prognosis. TMPRSS4 could be a valuable prognosis biomarker or a promising therapeutic target of solid tumor.
authors.affiliation: Department of Radiotherapy and Oncology, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, Jiangsu Province, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Zeng
authors.affiliation: Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Radiotherapy and Oncology, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, Jiangsu Province, China.
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Zhou
authors.affiliation: Department of Radiotherapy and Oncology, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, Jiangsu Province, China.
authors.forename: Min
authors.initials: M
authors.lastname: Tang
authors.affiliation: Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Yi-Xin
authors.initials: YX
authors.lastname: Shen
authors.affiliation: Department of Radiotherapy and Oncology, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, Jiangsu Province, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Jin
authors.affiliation: Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, Institute of Radiotherapy & Oncology, Soochow University, Suzhou, China.
authors.forename: Ya-Qun
authors.initials: YQ
authors.lastname: Zhu
authors.affiliation: Department of Radiotherapy and Oncology, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, Jiangsu Province, China.
authors.forename: Min-Bin
authors.initials: MB
authors.lastname: Chen
mesh_terms: D014408:Biomarkers, Tumor; D018450:Disease Progression; D015870:Gene Expression; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality*; D011379:Prognosis; D017594:Publication Bias; D012697:Serine Endopeptidases / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; D008565:Membrane Proteins; D012697:Serine Endopeptidases; C528837:TMPRSS4 protein, human
keywords: TMPRSS4; overall survival; prognosis; time to tumor progression; tumor