title: NMR Meets Tau: Insights into Its Function and Pathology.
abstract: In this review, we focus on what we have learned from Nuclear Magnetic Resonance (NMR) studies on the neuronal microtubule-associated protein Tau. We consider both the mechanistic details of Tau: the tubulin relationship and its aggregation process. Phosphorylation of Tau is intimately linked to both aspects. NMR spectroscopy has depicted accurate phosphorylation patterns by different kinases, and its non-destructive character has allowed functional assays with the same samples. Finally, we will discuss other post-translational modifications of Tau and its interaction with other cellular factors in relationship to its (dys)function.
authors.affiliation: Unit&#233; de Glycobiologie Structurale et Fontionnelle, University of Lille (UGSF), Villeneuve d'Ascq CNRS UMR Lille 8576, France. Guy.Lippens@insa-toulouse.fr.|Laboratoire d'Ing&#233;nierie des Syst&#232;mes Biologiques et des Proc&#233;d&#233;s (LISBP), University of Toulouse, CNRS, INRA, INSA, Toulouse 31400, France. Guy.Lippens@insa-toulouse.fr.
authors.forename: Guy
authors.initials: G
authors.lastname: Lippens
authors.affiliation: Unit&#233; de Glycobiologie Structurale et Fontionnelle, University of Lille (UGSF), Villeneuve d'Ascq CNRS UMR Lille 8576, France. isabelle.landrieu@univ-lille1.fr.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Landrieu
authors.affiliation: Unit&#233; de Glycobiologie Structurale et Fontionnelle, University of Lille (UGSF), Villeneuve d'Ascq CNRS UMR Lille 8576, France. caroline.smet@univ-lille1.fr.
authors.forename: Caroline
authors.initials: C
authors.lastname: Smet
authors.affiliation: Unit&#233; de Glycobiologie Structurale et Fontionnelle, University of Lille (UGSF), Villeneuve d'Ascq CNRS UMR Lille 8576, France. isabelle.huvent@univ-lille1.fr.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Huvent
authors.affiliation: School of Mathematical Sciences, Queensland University of Technology, Brisbane 4001 QLD, Australia. neha.gandhi@qut.edu.au.
authors.forename: Neha S
authors.initials: NS
authors.lastname: Gandhi
authors.affiliation: Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Universit&#233; Paris-Sud, Universit&#233; Paris-Saclay, Gif-sur-Yvette 91190, France. Benoit.Gigant@i2bc.paris-saclay.fr.
authors.forename: Benoît
authors.initials: B
authors.lastname: Gigant
authors.affiliation: Unit&#233; de Glycobiologie Structurale et Fontionnelle, University of Lille (UGSF), Villeneuve d'Ascq CNRS UMR Lille 8576, France. clement.despres@ed.univ-lille1.fr.
authors.forename: Clément
authors.initials: C
authors.lastname: Despres
authors.affiliation: Unit&#233; de Glycobiologie Structurale et Fontionnelle, University of Lille (UGSF), Villeneuve d'Ascq CNRS UMR Lille 8576, France. haoling.qi160687@gmail.com.
authors.forename: Haoling
authors.initials: H
authors.lastname: Qi
authors.affiliation: Unit&#233; de Glycobiologie Structurale et Fontionnelle, University of Lille (UGSF), Villeneuve d'Ascq CNRS UMR Lille 8576, France. juan.lopez@pucp.edu.pe.|Sciences Department-Chemistry, Pontifical Catholic University of Peru (PUCP), Av. Universitaria 1801, Lima 32, Peru. juan.lopez@pucp.edu.pe.
authors.forename: Juan
authors.initials: J
authors.lastname: Lopez
mesh_terms: D064267:Intrinsically Disordered Proteins / Q000737:chemistry / Q000378:metabolism; D019906:Nuclear Magnetic Resonance, Biomolecular; D011499:Protein Processing, Post-Translational; D014404:Tubulin / Q000737:chemistry / Q000378:metabolism; D016875:tau Proteins / Q000737:chemistry* / Q000378:metabolism
chemical_list: D064267:Intrinsically Disordered Proteins; D014404:Tubulin; D016875:tau Proteins
keywords: NMR spectroscopy; Tau; aggregation; intrinsically disordered protein; phosphorylation; protein/protein interactions; tubulin