title: [Bone morphogenetic proteins (BMP): clinical application for reconstruction of bone defects].
abstract: Since the introduction of bone morphogenetic proteins, their use has become an invaluable ally for the treatment of bone defects. These proteins are potent growth factors, related to angiogenic and osteogenic activity. The osteoinductive capacity of recombinant bone morphogenetic protein (rhBMP) in the formation of bone and cartilage has been confirmed in in vitro studies and evaluated in clinical trials. To obtain a therapeutic effect, administration is systemic, by injection over the physiological dose. Among the disadvantages, ectopic bone formation or high morbidity in cases of spinal fusion is observed. In this review, the roles of bone morphogenetic proteins in bone repair and clinical applications are analyzed. These findings represent advances in the study of bone regeneration and application of growth factors for more predictable results.
authors.affiliation: Departamento de Química, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, Monterrey, N.L., México.
authors.forename: Gerardo Daniel
authors.initials: GD
authors.lastname: Sierra-García
authors.affiliation: Departamento de Química Analítica, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, N.L., México.
authors.forename: Rocío
authors.initials: R
authors.lastname: Castro-Ríos
authors.affiliation: Departamento de Química, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, Monterrey, N.L., México.
authors.forename: Azucena
authors.initials: A
authors.lastname: Gónzalez-Horta
authors.affiliation: Banco de Huesos y Tejidos, Hospital Universitario Dr. José E. González, Universidad Autónoma de Nuevo León, Monterrey, N.L., México.
authors.forename: Jorge
authors.initials: J
authors.lastname: Lara-Arias
authors.affiliation: Departamento de Química, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, Monterrey, N.L., México.
authors.forename: Abelardo
authors.initials: A
authors.lastname: Chávez-Montes
mesh_terms: D001847:Bone Diseases / Q000473:pathology / Q000628:therapy*; D019485:Bone Morphogenetic Proteins / Q000008:administration & dosage* / Q000009:adverse effects; D001861:Bone Regeneration / Q000187:drug effects*; D006801:Humans; D007267:Injections; D009999:Ossification, Heterotopic / Q000139:chemically induced; D010012:Osteogenesis / Q000187:drug effects; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000009:adverse effects; D013123:Spinal Fusion / Q000379:methods
chemical_list: D019485:Bone Morphogenetic Proteins; D011994:Recombinant Proteins