title: Water Determination in Solid Pharmaceutical Products Utilizing Ionic Liquids and Headspace Gas Chromatography.
abstract: A rapid, accurate, and precise headspace gas chromatographic (HSGC) analytical method was developed for the detection and quantification of water in drug products. The analysis is able to be performed in 10 min and automated. The HSGC method used an ionic liquid (IL) based open tubular capillary gas chromatographic column to increase the ruggedness of this method and provide improved peak shapes for water. Due to the ionic liquids low vapor pressure, unique physiochemical properties, and high thermal stability, they also make idea solvents for HSGC. Unlike Karl Fischer titration methods, this HSGC method is not affected by side reactions. The developed method was shown to be broadly applicable. The water content in 12 different samples was found to range from 1%-7% water. The use of HSGC was highly sensitive and only required 10 mg of sample. In addition, it was found to have greater precision and accuracy than Karl Fischer titration and greater precision and speed than loss on drying.
authors.affiliation: Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, Texas 76019.
authors.forename: Lillian A
authors.initials: LA
authors.lastname: Frink
authors.affiliation: Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, Texas 76019. Electronic address: sec4dwa@uta.edu.
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Armstrong
mesh_terms: D002849:Chromatography, Gas; D004339:Drug Compounding / Q000295:instrumentation / Q000379:methods; D004340:Drug Contamination / Q000517:prevention & control*; D004355:Drug Stability; D006358:Hot Temperature; D052578:Ionic Liquids / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000737:chemistry* / Q000592:standards; D014867:Water / Q000032:analysis*
chemical_list: D052578:Ionic Liquids; D004364:Pharmaceutical Preparations; D014867:Water
keywords: analysis; analytical chemistry; chromatography; separation science; water in solids