title: An integrated logic system for time-resolved fluorescent "turn-on" detection of cysteine and histidine base on terbium (III) coordination polymer-copper (II) ensemble.
abstract: Cysteine (Cys) and histidine (His) both play indispensable roles in many important biological activities. An enhanced Cys level can result in Alzheimer's and cardiovascular diseases. Likewise, His plays a significant role in the growth and repair of tissues as well as in controlling the transmission of metal elements in biological bases. Therefore, it is meaningful to detect Cys and His simultaneously. In this work, a novel terbium (III) coordination polymer-Cu (II) ensemble (Tb(3+)/GMP-Cu(2+)) was proposed. Guanosine monophosphate (GMP) can self-assemble with Tb(3+) to form a supramolecular Tb(3+) coordination polymer (Tb(3+)/GMP), which can be suited as a time-resolved probe. The fluorescence of Tb(3+)/GMP would be quenched upon the addition of Cu(2+), and then the fluorescence of the as-prepared Tb(3+)/GMP-Cu(2+) ensemble would be restored again in the presence of Cys or His. By incorporating N-Ethylmaleimide and Ni(2+) as masking agents, Tb(3+)/GMP-Cu(2+) was further exploited as an integrated logic system and a specific time-resolved fluorescent "turn-on" assay for simultaneously sensing His and Cys was designed. Meanwhile it can also be used in plasma samples, showing great potential to meet the need of practical application.
authors.affiliation: School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China.
authors.forename: Shi-Fan
authors.initials: SF
authors.lastname: Xue
authors.affiliation: School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China.
authors.forename: Ling-Fei
authors.initials: LF
authors.lastname: Lu
authors.affiliation: School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China.
authors.forename: Qi-Xian
authors.initials: QX
authors.lastname: Wang
authors.affiliation: Fujian Provincial Key Laboratory of Nanomaterials, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China.
authors.forename: Shengqiang
authors.initials: S
authors.lastname: Zhang
authors.affiliation: School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Electronic address: mzhang@chem.ecnu.edu.cn.
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.affiliation: School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Electronic address: gyshi@chem.ecnu.edu.cn.
authors.forename: Guoyue
authors.initials: G
authors.lastname: Shi
mesh_terms: D000818:Animals; D056831:Coordination Complexes / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D003545:Cysteine / Q000032:analysis* / Q000097:blood / Q000737:chemistry; D005453:Fluorescence; D006157:Guanosine Monophosphate / Q000737:chemistry*; D006639:Histidine / Q000032:analysis* / Q000097:blood / Q000737:chemistry; D008128:Logic; D008297:Male; D011108:Polymers / Q000737:chemistry; D051381:Rats; D013725:Terbium / Q000737:chemistry*
chemical_list: D056831:Coordination Complexes; D011108:Polymers; D013725:Terbium; D006639:Histidine; D003300:Copper; D006157:Guanosine Monophosphate; D003545:Cysteine
keywords: Coordination polymer; Cu(2+); Cysteine; Histidine; Logic gate; Time-resolved