title: Efficacy and tolerability of trazodone retard monotherapy: results of the Serbian non-interventional study.
abstract: OBJECTIVE
  Trazodone is an effective antidepressant. The present study was designed as a non-interventional open-label, multi-centre, post-marketing study. The aim of the study was to evaluate the therapeutic effectiveness and tolerability of trazodone retard formulation (Trittico(®) retard) in everyday clinical practice.
  
  
  METHODS
  Two hundred and forty-two patients with depressive disorder from 19 different centres were included in the study. The antidepressant and anxyolitic effects were assessed using Hamilton anxiety rating scale 14 items version, Hamilton depression rating scale 14 items version and Clinical Global Impression Severity scale.
  
  
  RESULTS
  After only two weeks of therapy, a statistically significant improvement in the HAM-D score, was observed. This observation was maintained over the whole study period, up to the day 56.
  
  
  CONCLUSIONS
  Our study points toward clinical effectiveness of the prolonged-release formulation of trazodone in the treatment of unselected depressed patients in real-world practice.
authors.affiliation: a Institute of Mental Health , Belgrade , Serbia ;|b School of Medicine , University of Belgrade , Belgrade , Serbia.
authors.forename: Cedo D
authors.initials: CD
authors.lastname: Miljevic
authors.affiliation: a Institute of Mental Health , Belgrade , Serbia ;|b School of Medicine , University of Belgrade , Belgrade , Serbia.
authors.forename: Dusica
authors.initials: D
authors.lastname: Lečić-Toševski
authors.lastname: Trazodone Study Group Serbia
mesh_terms: D000328:Adult; D003692:Delayed-Action Preparations; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D055771:Serbia; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D014196:Trazodone / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*
chemical_list: D003692:Delayed-Action Preparations; D017367:Selective Serotonin Reuptake Inhibitors; D014196:Trazodone
keywords: Depression; psychopharmacology; trazodone