title: Study of Gallium Oxide Nanoparticles Conjugated with β-Cyclodextrin: An Application To Combat Cancer.
abstract: Bioactive nanomaterials, namely, gallium oxyhydroxide GaO(OH), also surface-conjugated GaO(OH) with a giant sugar molecule β-cyclodextrin (CD), have been prepared through a simple wet chemical route such that the same could be suitably used in biomedical diagnostics as well as therapeutic applications. Several physical methods were used for their characterization: powder X-ray diffraction pattern of GaO(OH) NPs for their grain size determination, optical spectroscopic absorption (UV-vis and FT-IR), and fluorescence properties of these NPs to ascertain surface conjugation and also their wide band-gap properties. Besides these, morphological properties of these NPs were studied by transmission electron microscopic (TEM) investigation, justifying the elemental constitution through energy dispersive X-ray analysis (EDX). Further, biological cellular uptake of these nanoparticles have been demonstrated on cancerous HeLa cells and reported with total fetal effect after 72 h, with CD templated GaO(OH) nanoparticles, a fact that has not been reported so far.
authors.affiliation: Saha Institute of Nuclear Physics , 1/AF Bidhannagar, Kolkata 700064, India.
authors.forename: Bichitra Nandi
authors.initials: BN
authors.lastname: Ganguly
authors.affiliation: IISER-Pune , Dr. Homi Bhabha Road, Pashan, Pune 411008, India.
authors.forename: Vivek
authors.initials: V
authors.lastname: Verma
authors.affiliation: IISER-Kolkata , Mohanpur 741246, West Bengal, India.
authors.forename: Debanuj
authors.initials: D
authors.lastname: Chatterjee
authors.affiliation: Saha Institute of Nuclear Physics , 1/AF Bidhannagar, Kolkata 700064, India.
authors.forename: Biswarup
authors.initials: B
authors.lastname: Satpati
authors.affiliation: Saha Institute of Nuclear Physics , 1/AF Bidhannagar, Kolkata 700064, India.
authors.forename: Sushanta
authors.initials: S
authors.lastname: Debnath
authors.affiliation: Saha Institute of Nuclear Physics , 1/AF Bidhannagar, Kolkata 700064, India.
authors.forename: Partha
authors.initials: P
authors.lastname: Saha
mesh_terms: D005708:Gallium; D006367:HeLa Cells; D006801:Humans; D053768:Metal Nanoparticles; D017550:Spectroscopy, Fourier Transform Infrared; D047392:beta-Cyclodextrins
chemical_list: D047392:beta-Cyclodextrins; C038863:gallium oxide; D005708:Gallium
keywords: GaO(OH) conjugated with β-cyclodextrin/GaO(OH)−CD; TEM; band gap; gallium oxide hydroxide/GaO(OH); in vitro cellular studies; size of the nanoparticles; β-cyclodextrin