title: Retrospective evaluation of the effect of high flow oxygen therapy delivered by nasal cannula on PaO2 in dogs with moderate-to-severe hypoxemia.
abstract: OBJECTIVE
  To describe the effects of high flow oxygen therapy (HFOT) in canine patients failing traditional oxygen therapy (TOT).
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Private referral practice.
  
  
  METHODS
  Six client-owned dogs with primary pulmonary hypoxemia.
  
  
  METHODS
  None.
  
  
  RESULTS
  High flow oxygen was delivered by high flow nasal prongs to dogs assessed clinically to be failing TOTs. HFOT was able to significantly improve PaO2 compared to TOT in severely hypoxemic dogs (median, 133.75 mm Hg; range, 109.2-304.8) versus median 61.85 mm Hg (range, 52.3-71.8; xsP = 0.0412). Flow rates were significantly higher with HFOT compared to TOT (median, 688 mL/kg/min; range, 523-1,667 mL/kg/min) versus median 122 mL/kg/min (range, 80-208; P = 0.0412). Complications included patient discomfort requiring light sedation in 1/6 dogs and persistence of a pneumothorax in 1 dog. Hypoxemia resolved in 4/6 dogs.
  
  
  CONCLUSIONS
  These data suggest HFOT is a viable clinical intervention for dogs with moderate-to-severe hypoxemia assessed to be failing TOT. Further studies are needed to determine if HFOT can be used as an alternative to mechanical ventilation in resource limited settings and to characterize the complications associated with this therapy.
authors.affiliation: From the Center for Critical Care Nephrology, The CRISMA (Clinical Research, Investigation, and Systems Modeling of Acute Illness) Center, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, 15260.|Allegheny Veterinary, Emergency, Trauma and Specialty (AVETS), Pittsburgh, PA, 15146.
authors.forename: Iain
authors.initials: I
authors.lastname: Keir
authors.affiliation: Pittsburgh Veterinary Specialty and Emergency Center Pittsburgh, PA, 125237.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Daly
authors.affiliation: Pittsburgh Veterinary Specialty and Emergency Center Pittsburgh, PA, 125237.
authors.forename: Jamie
authors.initials: J
authors.lastname: Haggerty
authors.affiliation: Pittsburgh Veterinary Specialty and Emergency Center Pittsburgh, PA, 125237.
authors.forename: Christine
authors.initials: C
authors.lastname: Guenther
mesh_terms: D000818:Animals; D001784:Blood Gas Analysis / Q000662:veterinary; D000072601:Cannula / Q000662:veterinary; D004283:Dog Diseases / Q000628:therapy*; D004285:Dogs; D005260:Female; D000860:Hypoxia / Q000628:therapy / Q000662:veterinary*; D008297:Male; D010100:Oxygen / Q000008:administration & dosage* / Q000097:blood; D010102:Oxygen Inhalation Therapy / Q000662:veterinary*; D012189:Retrospective Studies; D012720:Severity of Illness Index
chemical_list: D010100:Oxygen
keywords: canine; hypoxia; pulmonary failure; respiratory