title: Systematic Analysis of Integrated Gene Functional Network of Four Chronic Stress-related Lifestyle Disorders.
abstract: BACKGROUND
  Stress is a term used to define factors involved in changes in the physiological balances resulting in disease conditions. Chronic exposure to stress conditions in modern lifestyles has resulted in a group of disorders called lifestyle disorders. Genetic background and environmental factors are interrelated to lifestyle in determining the health status of individuals. Hence, identification of disease-associated genes is the primary step toward explanations of pathogenesis of these diseases. In functional genomics, large-scale molecular and physiological data are used for the identification of causative genes associated with a disease.
  
  
  OBJECTIVE
  The objective of our study was to find a common set of genes involved in chronic stress-related lifestyle diseases such as cardiovascular diseases (CVDs), type 2 diabetes (T2D), hypertension (HTN), and obesity.
  
  
  METHODS
  In our study, we have performed a systematic analysis of the functional gene network of four chronic stress-related lifestyle diseases by retrieving genes from published databases. We have tried to systematically construct a functional protein-protein interaction (PPI) network. The goals of establishing this network were the functional enrichment study of interacting partners as well as functional disease ontology annotation (FunDO) of the enriched genes.
  
  
  RESULTS
  This study enabled the identification of key genes involved in these stress-related lifestyle diseases by prioritizing candidate genes based on their degree of involvement. In this systematic analysis, we have found key genes for these diseases based on their involvement and association at the gene network level and PPI.
  
  
  CONCLUSIONS
  We have deciphered a group of genes that in combination play a crucial role and may impact the function of the whole genome in the four lifestyle disorders mentioned.
authors.affiliation: Molecular Stress and Stem Cell Biology Group, School of Biotechnology, KIIT University, Bhubaneswar, Odisha-751024, India.
authors.forename: Souvick
authors.initials: S
authors.lastname: Roy
authors.affiliation: Molecular Stress and Stem Cell Biology Group, School of Biotechnology, KIIT University, Bhubaneswar, Odisha-751024, India.
authors.forename: Abhik
authors.initials: A
authors.lastname: Chakraborty
authors.affiliation: Molecular Stress and Stem Cell Biology Group, School of Biotechnology, KIIT University, Bhubaneswar, Odisha-751024, India.
authors.forename: Chinmoy
authors.initials: C
authors.lastname: Ghosh
authors.affiliation: Molecular Stress and Stem Cell Biology Group, School of Biotechnology, KIIT University, Bhubaneswar, Odisha-751024, India.
authors.forename: Birendranath
authors.initials: B
authors.lastname: Banerjee
keywords: Chronic stress; cardiovascular disease (CVD); hypertension (HTN); lifestyle; obesity; type 2 diabetes (T2D)