title: Effect of Strontium Chloride on Experimental Bladder Inflammation in Rat.
abstract: Introduction. Strontium salts are anti-irritants for chemically induced sensory irritation. Interstitial cystitis is a painful disease without definitive therapy. The aim of the study was to determine the effect of strontium in bladder with experimental interstitial cystitis model. Material and Methods. Rats' bladders in control group were instilled with NaCl. Second group was instilled with E. coli LPS. Third group was instilled with strontium. Fourth group was initially instilled with strontium and then LPS. Fifth group was instilled with LPS initially and then strontium. Urine of rats was collected at the beginning and end of the study. Results. Histamine and TNF-α changes were statistically significant in the second group but were not significant in the third group. When we compared the histamine levels of second via fourth and fifth groups the changes were statistically not significant. When we compared the TNF-α levels of second via fourth and fifth groups the changes were statistically significant. Conclusions. In our model, strontium did not make any significant changes in histopathology or histamine levels; however, it significantly reduced the levels of TNF-α. Given the role of TNF-α in the physiopathology of interstitial cystitis, these results suggested that further studies are required to evaluate the potential use of strontium in the management of interstitial cystitis.
authors.affiliation: Department of Urology, Medical Faculty, Cumhuriyet University, Urology Clinic, 58140 Sivas, Turkey.
authors.forename: Esat
authors.identifier: 0000-0003-0318-0353
authors.initials: E
authors.lastname: Korgali
authors.affiliation: Department of Urology, Medical Faculty, Cumhuriyet University, Urology Clinic, 58140 Sivas, Turkey.
authors.forename: Gokce
authors.identifier: 0000-0002-6676-1983
authors.initials: G
authors.lastname: Dundar
authors.affiliation: Department of Bioengineering, Natural Sciences and Engineering Faculty, Gaziosmanpasa University, 60250 Tokat, Turkey.
authors.forename: Kubra Acikalin
authors.initials: KA
authors.lastname: Coskun
authors.affiliation: Department of Dermatology, Medical Faculty, Cumhuriyet University, 58140 Sivas, Turkey.
authors.forename: Melih
authors.initials: M
authors.lastname: Akyol
authors.affiliation: Department of Biochemistry, Pharmacy Faculty, Cumhuriyet University, 58140 Sivas, Turkey.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Tutar
authors.affiliation: Department of Urology, Medical Faculty, Cumhuriyet University, Urology Clinic, 58140 Sivas, Turkey.
authors.forename: Semih
authors.initials: S
authors.lastname: Ayan
authors.affiliation: Department of Urology, Medical Faculty, Cumhuriyet University, Urology Clinic, 58140 Sivas, Turkey.
authors.forename: Gokhan
authors.initials: G
authors.lastname: Gokce
authors.affiliation: Department of Urology, Medical Faculty, Cumhuriyet University, Urology Clinic, 58140 Sivas, Turkey.
authors.forename: Emin Yener
authors.initials: EY
authors.lastname: Gultekin