title: [Brain plastic alterations in subjects with chronic right-sided sensorineural hearing loss: a resting-state MRI study].
abstract: OBJECTIVE
  To investigate the nodal properties and reorganization of whole-brain functional network in subjects with severe right-sided SNHL.
  
  
  METHODS
  From June 2012 to June 2013, a total of 19 patients with severe right-sided SNHL were collected from Zhongda Hospital or the recruitment advertising along with 31 healthy controls.Based on the graph-theoretical analysis, the whole-brain functional networks were constructed using the BOLD-fMRI data of all subjects.Two sample two-tailed t-tests were used to investigate the differences between two groups in nodal metrics, such as node degree, node betweenness, node global efficiency and node local efficiency.All metrics were corrected by multiple comparisons.Partial correlation analysis was used to estimate the relationship between the significant metrics and the duration or severity of hearing loss.
  
  
  RESULTS
  The right-sided SNHL showed significantly increased betweenness centrality in left supramarginal gyrus and right fusiform.However, other nodal parameters showed no statistical difference.Besides, patients exhibited no significant association between the altered metrics and clinical variables.
  
  
  CONCLUSIONS
  Alterations of local topological properties may underlie cerebral cross-modal plastic reorganization in visual or speech-related regions in severe right-sided SNHL patients.
authors.affiliation: Department of Radiology, the Second Hospital Affiliated to Suzhou University, Suzhou 215004, China.
authors.forename: L L
authors.initials: LL
authors.lastname: Zhang
authors.forename: J P
authors.initials: JP
authors.lastname: Gong
authors.forename: Y W
authors.initials: YW
authors.lastname: Xu
authors.forename: B
authors.initials: B
authors.lastname: Liu
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001931:Brain Mapping; D002908:Chronic Disease; D007839:Functional Laterality; D059907:Functional Neuroimaging; D006319:Hearing Loss, Sensorineural / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000503:physiopathology; D009473:Neuronal Plasticity / Q000502:physiology*