title: Dendritic and Axonal Wiring Optimization of Cortical GABAergic Interneurons.
abstract: The way in which a neuronal tree expands plays an important role in its functional and computational characteristics. We aimed to study the existence of an optimal neuronal design for different types of cortical GABAergic neurons. To do this, we hypothesized that both the axonal and dendritic trees of individual neurons optimize brain connectivity in terms of wiring length. We took the branching points of real three-dimensional neuronal reconstructions of the axonal and dendritic trees of different types of cortical interneurons and searched for the minimal wiring arborization structure that respects the branching points. We compared the minimal wiring arborization with real axonal and dendritic trees. We tested this optimization problem using a new approach based on graph theory and evolutionary computation techniques. We concluded that neuronal wiring is near-optimal in most of the tested neurons, although the wiring length of dendritic trees is generally nearer to the optimum. Therefore, wiring economy is related to the way in which neuronal arborizations grow irrespective of the marked differences in the morphology of the examined interneurons.
authors.affiliation: Departamento de Inteligencia Artificial, Escuela Técnica Superior de Ingenieros Informáticos, Universidad Politécnica de Madrid, Madrid, Spain. l.anton-sanchez@upm.es.
authors.forename: Laura
authors.identifier: 0000-0002-5556-1759
authors.initials: L
authors.lastname: Anton-Sanchez
authors.affiliation: Departamento de Inteligencia Artificial, Escuela Técnica Superior de Ingenieros Informáticos, Universidad Politécnica de Madrid, Madrid, Spain.
authors.forename: Concha
authors.initials: C
authors.lastname: Bielza
authors.affiliation: Laboratorio Cajal de Circuitos Corticales, Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, Madrid, Spain.|Instituto Cajal, Consejo Superior de Investigaciones Científicas, Madrid, Spain.
authors.forename: Ruth
authors.initials: R
authors.lastname: Benavides-Piccione
authors.affiliation: Laboratorio Cajal de Circuitos Corticales, Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, Madrid, Spain.|Instituto Cajal, Consejo Superior de Investigaciones Científicas, Madrid, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: DeFelipe
authors.affiliation: Departamento de Inteligencia Artificial, Escuela Técnica Superior de Ingenieros Informáticos, Universidad Politécnica de Madrid, Madrid, Spain.
authors.forename: Pedro
authors.initials: P
authors.lastname: Larrañaga
mesh_terms: D000465:Algorithms; D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology*; D059330:GABAergic Neurons / Q000166:cytology*; D006801:Humans; D021621:Imaging, Three-Dimensional; D007395:Interneurons / Q000166:cytology*; D008959:Models, Neurological; D009434:Neural Pathways / Q000166:cytology; D056347:Neuroanatomical Tract-Tracing Techniques; D012984:Software
keywords: Dendritic and axonal arborizations; Evolutionary computation; Graph theory; Interneurons; Neocortex; Wiring economy