title: A metal-catalyzed enyne-cyclization step for the synthesis of bi- and tricyclic scaffolds amenable to molecular library production.
abstract: A facile metal-catalyzed diversification step for the synthesis of novel bi- and tricyclic scaffolds from enyne substrates is reported in this study. From a single starting material, topologically diverse scaffolds for library synthesis can be generated and decorated in a few steps. The methodology was used to produce a library of 490 compounds within the European Lead Factory (ELF) Consortium.
authors.affiliation: Department of Chemistry, Technical University of Denmark, DK-2800, Kgs. Lyngby, Denmark. ten@sund.ku.dk.
authors.forename: Peng
authors.initials: P
authors.lastname: Wu
authors.forename: Michael Åxman
authors.initials: MÅ
authors.lastname: Petersen
authors.forename: A Emil
authors.initials: AE
authors.lastname: Cohrt
authors.forename: Rico
authors.initials: R
authors.lastname: Petersen
authors.forename: Rémy
authors.initials: R
authors.lastname: Morgentin
authors.forename: Hugues
authors.initials: H
authors.lastname: Lemoine
authors.forename: Carine
authors.initials: C
authors.lastname: Roche
authors.forename: Anthony
authors.initials: A
authors.lastname: Willaume
authors.forename: Mads H
authors.initials: MH
authors.lastname: Clausen
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Nielsen