title: Justicidin B: A Promising Bioactive Lignan.
abstract: Adverse effects and drug resistance to the current onchopharmacologicals have increased the demand for alternative novel therapeutics. We herein introduce justicidin B, an arylnaphthalen lignan isolated from different plant origins, especially Justicia, Phyllanthus, Haplophyllum and Linum species. This cyclolignan exhibits a wide array of biological properties ranges from piscicidal to antifungal, antiviral and antibacterial activities. Activity against Trypanosoma brucei makes justicidin B a potential antiprotozoal agent for the treatment of neglected tropical diseases. Pharmacological properties like antiplatelet, anti-inflammatory and bone resorption inhibition have been also attributed to justicidin B. This compound is a potent cytotoxic substance on several cell lines, especially chronic myeloid and chronic lymphoid leukemia. Pharmacological values, natural variation, as well as biotechnological production of justicidin B by plant cell, tissue and organ culture are also described in this review. Chemical characteristics and chromatographic methods to identify justicidin B and its biosynthetic pathway have been discussed. Different approaches to the total synthesis of justicidin B are compared. This review would shed light on the role of justicidin B as an intriguing natural compound and provides a chance to optimize conditions for industrial applications.
authors.affiliation: Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, P. O. Box 71345-1583 Shiraz, Iran. hemmatish@sums.ac.ir.|Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, P. O. Box 71345-3119 Shiraz, Iran. hemmatish@sums.ac.ir.
authors.forename: Shiva
authors.initials: S
authors.lastname: Hemmati
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Shiraz University of Medical Sciences, P. O. Box 71345-1583 Shiraz, Iran. serajh@sums.ac.ir.
authors.forename: Hassan
authors.initials: H
authors.lastname: Seradj
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000494:pharmacology; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology; D053898:Biosynthetic Pathways; D001709:Biotechnology; D002621:Chemistry; D004148:Dioxolanes / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D017705:Lignans / Q000096:biosynthesis / Q000737:chemistry* / Q000494:pharmacology*; D055432:Metabolomics / Q000379:methods; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000494:pharmacology; D018675:Toxicity Tests
chemical_list: D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D000981:Antiprotozoal Agents; D001688:Biological Products; D004148:Dioxolanes; D017705:Lignans; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; C049719:justicidins
keywords: arylnaphthalene; biological activity; biosynthesis; biotechnological production; chemistry; chromatography; distribution; justicidin B; lignan; synthesis