title: Three cases of OXA-48-like carbapenemase producing Enterobacteriaceae (not) detected using Xpert®Carba-R.
abstract: The increasing prevalence of carbapenemase-producing Enterobacteriaceae necessitates laboratories to invest in the detection of these bacteria, both with phenotypic and to a lesser extent molecular methods. OXA-48-like strains are rapidly emerging, especially in Europe. Since the expression level of OXA-48 is low and some strains present with several alleles, some types might be missed by some molecular assays. Three cases of OXA-48-like strains are described here, where the detection was not straightforward.
authors.affiliation: a Department of Laboratory Medicine , Ghent University Hospital , Ghent , Belgium.
authors.forename: Jerina
authors.initials: J
authors.lastname: Boelens
authors.affiliation: b Department of Microbiology and Infection Control , UZ Brussel (Brussels University Hospital) , Brussels , Belgium.
authors.forename: Erlangga
authors.initials: E
authors.lastname: Yusuf
authors.affiliation: c Department of Intensive Care Medicine , Ghent University Hospital , Ghent , Belgium.
authors.forename: Johan
authors.initials: J
authors.lastname: Decruyenaere
authors.affiliation: a Department of Laboratory Medicine , Ghent University Hospital , Ghent , Belgium.
authors.forename: Liselotte
authors.initials: L
authors.lastname: Coorevits
authors.affiliation: b Department of Microbiology and Infection Control , UZ Brussel (Brussels University Hospital) , Brussels , Belgium.
authors.forename: Denis
authors.initials: D
authors.lastname: Piérard
authors.affiliation: a Department of Laboratory Medicine , Ghent University Hospital , Ghent , Belgium.|d Department of Clinical Chemistry, Immunology and Microbiology , Ghent University , Ghent , Belgium.
authors.forename: Geert
authors.initials: G
authors.lastname: Claeys
mesh_terms: D000369:Aged, 80 and over; D001431:Bacteriological Techniques; D000073182:Carbapenem-Resistant Enterobacteriaceae / Q000302:isolation & purification*; D004756:Enterobacteriaceae Infections / Q000175:diagnosis* / Q000382:microbiology* / Q000628:therapy; D005260:Female; D006801:Humans
keywords: CPE; OXA-48-like; laboratory confirmation