title: PBK/TOPK Expression Predicts Prognosis in Oral Cancer.
abstract: Oral cancer is a common cancer with poor prognosis. We evaluated the expression of PBK/TOPK (PDZ-binding kinase/T-LAK cell-originated protein kinase) and its prognostic significance in oral cancer. PBK/TOPK expression was measured by immunohistochemical staining of samples from 287 patients with oral cancer. The association between PBK/TOPK expression and clinicopathological features was analyzed. The prognostic value of PBK/TOPK for overall survival was determined by Kaplan-Meier analysis and Cox proportional hazard models. A high PBK/TOPK expression level was correlated with long overall survival. The prognostic role of PBK/TOPK expression was significant in young patients (p < 0.05), patients with smoking habits (p < 0.05), and late stage disease (p < 0.05). Our results suggest that PBK/TOPK expression is enhanced in oral cancer. High PBK/TOPK expression, either alone or in subgroups according to clinicopathological features, may serve as a favorable prognostic marker for patients with oral cancer.
authors.affiliation: Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan. benglung@hotmail.com.|Department of Otorhinolaryngology, Head and Neck Surgery, Jen-Ai Hospital, Taichung 400, Taiwan. benglung@hotmail.com.
authors.forename: Chin-Fang
authors.initials: CF
authors.lastname: Chang
authors.affiliation: School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan. cshy650@csh.org.tw.|Department of Urology, Chung Shan Medical University Hospital, Taichung 402, Taiwan. cshy650@csh.org.tw.
authors.forename: Sung-Lang
authors.initials: SL
authors.lastname: Chen
authors.affiliation: Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan. flutewayne@gmail.com.|School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan. flutewayne@gmail.com.|Department of Medical Education, Chung Shan Medical University Hospital, Taichung 402, Taiwan. flutewayne@gmail.com.|Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli 356, Taiwan. flutewayne@gmail.com.
authors.forename: Wen-Wei
authors.initials: WW
authors.lastname: Sung
authors.affiliation: Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan. 170780@cch.org.tw.|School of Optometry, Chung Shan Medical University, Taichung 402, Taiwan. 170780@cch.org.tw.|Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan. 170780@cch.org.tw.
authors.forename: Ming-Ju
authors.initials: MJ
authors.lastname: Hsieh
authors.affiliation: Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan. 128202@cch.org.tw.|School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan. 128202@cch.org.tw.|Department of Surgical Pathology, Changhua Christian Hospital, Changhua 500, Taiwan. 128202@cch.org.tw.
authors.forename: Hui-Ting
authors.initials: HT
authors.lastname: Hsu
authors.affiliation: School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan. arsenelupinchen@yahoo.com.tw.
authors.forename: Li-Hsin
authors.initials: LH
authors.lastname: Chen
authors.affiliation: School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan. 53780@cch.org.tw.|Department of Otorhinolaryngology, Head and Neck Surgery, Changhua Christian Hospital, Changhua 500, Taiwan. 53780@cch.org.tw.
authors.forename: Mu-Kuan
authors.initials: MK
authors.lastname: Chen
authors.affiliation: Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan. jlko@csmu.edu.tw.
authors.forename: Jiunn-Liang
authors.initials: JL
authors.lastname: Ko
authors.affiliation: School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan. 132540@cch.org.tw.|Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli 356, Taiwan. 132540@cch.org.tw.|Department of Surgical Pathology, Changhua Christian Hospital, Changhua 500, Taiwan. 132540@cch.org.tw.
authors.forename: Chih-Jung
authors.initials: CJ
authors.lastname: Chen
authors.affiliation: Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan. graduate@csmu.edu.tw.|School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan. graduate@csmu.edu.tw.
authors.forename: Ming-Chih
authors.initials: MC
authors.lastname: Chou
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020929:Mitogen-Activated Protein Kinase Kinases / Q000235:genetics / Q000378:metabolism*; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D020929:Mitogen-Activated Protein Kinase Kinases; C409022:PDZ-binding kinase
keywords: PBK (PDZ-binding kinase); TOPK (T-LAK cell-originated protein kinase); head and neck cancer; metastasis; oral squamous cell carcinoma; prognosis