title: Herpetic esophagitis following bendamustine-containing regimen.
abstract: A 76-year-old Japanese woman presented to our hospital with anorexia. Two years before, she was diagnosed with non-Hodgkin's lymphoma and had received ten cycles of systemic chemotherapy. After salvage chemotherapy with bendamustine and rituximab (B-R), bone marrow suppression had lasted >3 months. Esophagogastroscopy revealed polynesic white protrusions in the mid-esophagus. These lesions were diagnosed as herpetic esophagitis. To the best of our knowledge, there is no other report in which herpetic esophagitis has been documented as an adverse event of B-R regimen. Because the complication could cause symptomatic gastrointestinal discomfort, physicians should be aware of this disease.
authors.affiliation: Department of General Internal Medicine 4, Kawasaki Medical School, Kita-ku, Okayama, Japan.
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Yamane
authors.affiliation: Department of Pathology, Kawasaki Medical School, Kita-ku, Okayama, Japan.
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Monobe
authors.affiliation: Department of General Internal Medicine 2, Kawasaki Medical School, Kita-ku, Okayama, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Tanikawa
authors.affiliation: Department of General Internal Medicine 4, Kawasaki Medical School, Kita-ku, Okayama, Japan.
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Ochi
authors.affiliation: Department of General Internal Medicine 4, Kawasaki Medical School, Kita-ku, Okayama, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Honda
authors.affiliation: Department of General Internal Medicine 2, Kawasaki Medical School, Kita-ku, Okayama, Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Kawamoto
authors.affiliation: Department of General Internal Medicine 4, Kawasaki Medical School, Kita-ku, Okayama, Japan.
authors.forename: Nagio
authors.initials: N
authors.lastname: Takigawa
keywords: bendamustine; herpetic esophagitis; immunodeficiency; non-Hodgkin’s lymphoma; rituximab