title: Increased Velocity Storage in Subjects with Meniere's Disease.
abstract: OBJECTIVE
  Velocity storage mechanism is a multisensory rotation estimator; it compensates for errors in the information provided by the peripheral vestibular organs by means of an adjustment in the duration of the vestibular signal. The aim of this study was to determine the activity of the velocity storage mechanism in the presence of a labyrinthine disorder, using galvanic vestibular stimulation to cause direct activation of the vestibular afferent neurons.
  
  
  METHODS
  Forty-one subjects with definite Meniere's disease (MD) and 36 healthy volunteers were evaluated using a 20-s galvanic vestibular stimulation.
  
  
  RESULTS
  We found a post-stimulus nystagmus overshoot exclusively in subjects with MD (47% in subjects with unilateral disease and 82% in subjects with bilateral disease), but no overshoot in healthy subjects.
  
  
  CONCLUSIONS
  Because post-stimulus nystagmus overshoot is caused by the velocity storage mechanism, this finding suggests an increase in the velocity storage in subjects with a labyrinthine disease.
authors.affiliation: Department of Otolaryngology, Hospital Universitario y Politécnico La Fe, Valencia, Spain. claudio.krstulovic@outlook.com.
authors.forename: Claudio
authors.initials: C
authors.lastname: Krstulovic
authors.forename: Nabil
authors.initials: N
authors.lastname: Atrache Al Attrache
authors.forename: Herminio
authors.initials: H
authors.lastname: Pérez Garrigues
authors.forename: Herminia
authors.initials: H
authors.lastname: Argente-Escrig
authors.forename: Luis
authors.initials: L
authors.lastname: Bataller Alberola
authors.forename: Constantino
authors.initials: C
authors.lastname: Morera Pérez
mesh_terms: D000054:Acceleration; D000328:Adult; D000368:Aged; D004558:Electric Stimulation; D004584:Electronystagmography; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000503:physiopathology*; D008875:Middle Aged; D009475:Neurons, Afferent / Q000502:physiology*; D012016:Reference Values; D012027:Reflex, Vestibulo-Ocular / Q000502:physiology; D012399:Rotation; D012815:Signal Processing, Computer-Assisted; D009435:Synaptic Transmission / Q000502:physiology; D014724:Vestibular Function Tests; D014725:Vestibular Nerve / Q000503:physiopathology*; D014722:Vestibule, Labyrinth / Q000503:physiopathology*