title: Metformin promotes cholesterol efflux in macrophages by up-regulating FGF21 expression: a novel anti-atherosclerotic mechanism.
authors.affiliation: Department of Internal Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, 139 Middle Renmin Road, Changsha, 410011, People's Republic of China.
authors.forename: Fei
authors.initials: F
authors.lastname: Luo
authors.affiliation: Department of Internal Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, 139 Middle Renmin Road, Changsha, 410011, People's Republic of China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Department of Internal Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, 139 Middle Renmin Road, Changsha, 410011, People's Republic of China.
authors.forename: Guiyun
authors.initials: G
authors.lastname: Ruan
authors.affiliation: Department of Internal Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, 139 Middle Renmin Road, Changsha, 410011, People's Republic of China. lixp0040@sina.com.
authors.forename: Xiangping
authors.initials: X
authors.lastname: Li
mesh_terms: D064286:ATP Binding Cassette Transporter 1 / Q000819:agonists / Q000235:genetics / Q000378:metabolism; D000070998:ATP Binding Cassette Transporter, Subfamily G, Member 1 / Q000819:agonists / Q000235:genetics / Q000378:metabolism; D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D001692:Biological Transport; D002784:Cholesterol / Q000378:metabolism*; D005346:Fibroblast Growth Factors / Q000819:agonists* / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008687:Metformin / Q000494:pharmacology*; D051379:Mice; D018345:Mice, Knockout; D058226:Plaque, Atherosclerotic / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D061251:Primary Cell Culture; D016032:Randomized Controlled Trials as Topic; D015398:Signal Transduction
chemical_list: C577836:ABCA1 protein, human; C419353:ABCG1 protein, human; D064286:ATP Binding Cassette Transporter 1; D000070998:ATP Binding Cassette Transporter, Subfamily G, Member 1; D000924:Anticholesteremic Agents; D007004:Hypoglycemic Agents; C414620:fibroblast growth factor 21; D005346:Fibroblast Growth Factors; D008687:Metformin; D002784:Cholesterol
keywords: ABCA1; ABCG1; Cholesterol efflux; FGF21; Macrophage; Metformin