title: Comparison of serum Neuregulin 4 (Nrg4) levels in adults with newly diagnosed type 2 diabetes mellitus and controls without diabetes.
abstract: We explored the role of Neuregulin 4 (Nrg4), a newly described factor secreted by adipose tissue, by measuring serum Nrg4 levels in humans. Circulating Nrg4 levels were significantly higher in patients with diabetes mellitus compared with controls without diabetes and were correlated with the serum glucose level and insulin resistance.
authors.affiliation: Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon 35015, Republic of Korea.
authors.forename: Yea Eun
authors.initials: YE
authors.lastname: Kang
authors.affiliation: Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon 35015, Republic of Korea.
authors.forename: Ji Min
authors.initials: JM
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon 35015, Republic of Korea.
authors.forename: Sorim
authors.initials: S
authors.lastname: Choung
authors.affiliation: Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon 35015, Republic of Korea.
authors.forename: Kyong Hye
authors.initials: KH
authors.lastname: Joung
authors.affiliation: Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon 35015, Republic of Korea.
authors.forename: Ju Hee
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon 35015, Republic of Korea. Electronic address: kimhj43@cnuh.co.kr.
authors.forename: Hyun Jin
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon 35015, Republic of Korea. Electronic address: bonjeong@cnu.ac.kr.
authors.forename: Bon Jeong
authors.initials: BJ
authors.lastname: Ku
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D020880:Neuregulins / Q000097:blood*
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D020880:Neuregulins; C467747:neuregulin-4
keywords: Adipokine; Diabetes mellitus; Neuregulin 4