title: [Analysis of influence of inflammatory factor in patients with ovarian endometriosis follicular fluid on the outcome of in vitro fertilization].
abstract: OBJECTIVE
  To observe the effect of follicular fluid IL-6, TNF-α on the clinical outcome of in vitro fertilization and embryo transfer (IVF-ET) in patients with ovarian endometriosis.
  
  
  METHODS
  From June 2013 to June 2014, the data of 64 (from Tangshan Maternal and Child Health Hospital IVF center) ovarian endometriosis patients was analyzed retrospectively. 58 infertility cases caused by male side were used as control group. Oocyte retrieval rate, M II oocytes rate, fertilization rate, recovery-intracytoplasmic sperm injection (R-ICSI) rate, good quality embryo rate, biochemical pregnancy rate and clinical pregnancy rate were analyzed and compared between two groups. Changes in the expression of follicular fluid IL-6, TNF-α were detected.
  
  
  RESULTS
  Oocyte retrieval rate, M II oocytes rate, fertilization rate, good quality embryo rate, biochemical pregnancy rate and clinical pregnancy rate in ovarian endometriosis group were significantly lower than those in the control group (all P < 0.05), while R-ICSI rate increased in ovarian endometriosis group compared with control group (P < 0.05). IL-6, TNF-α expressions of follicular fluid were higher in affected side of ovarian endometriosis patients than those in the unaffected side and those in control group.
  
  
  CONCLUSIONS
  Inflammation microenvironment of the follicular fluid may influence IVF-ET outcomes in ovarian endometriosis patients.
authors.forename: Yanchun
authors.initials: Y
authors.lastname: Ning
authors.forename: Baolian
authors.initials: B
authors.lastname: Liu
authors.forename: Baosheng
authors.initials: B
authors.lastname: Han
authors.forename: Jian
authors.initials: J
authors.lastname: Guo
authors.forename: Xiurong
authors.initials: X
authors.lastname: Liu
authors.forename: Guiling
authors.initials: G
authors.lastname: Fan
authors.forename: Chang
authors.initials: C
authors.lastname: Guo
authors.forename: Fenglan
authors.initials: F
authors.lastname: Wang
authors.forename: Jin
authors.initials: J
authors.lastname: Zhou
authors.forename: Lirong
authors.initials: L
authors.lastname: Yin
mesh_terms: D016022:Case-Control Studies; D004624:Embryo Transfer; D004715:Endometriosis / Q000473:pathology*; D005260:Female; D005307:Fertilization in Vitro; D015571:Follicular Fluid / Q000737:chemistry*; D006801:Humans; D007247:Infertility, Female / Q000473:pathology*; D007249:Inflammation / Q000473:pathology*; D015850:Interleukin-6 / Q000737:chemistry; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic; D014409:Tumor Necrosis Factor-alpha / Q000737:chemistry
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha