title: MicroRNAs as biomarkers in leukemia.
abstract: Current diagnostic and prognostic markers still exhibit biological limitation and seeking novel molecular biomarkers is crucial for early clinical diagnosis and in the development of novel strategies for leukemia therapy. Emerging evidence showed that dysregulated microRNAs (miRNAs) play important roles in cancer including leukemia. In this review, we summarized recent progress on the role of miRNAs in leukemia, mainly focusing on recent findings that suggest the potential of miRNAs as biomarkers for diagnosis and prognosis. Notably, the circulating miRNAs were also discussed for the fact that they can be detected in body fluids, and thus represent a novel source of promising biomarkers that may be applied to clinical settings.
authors.affiliation: China-America Cancer Research Institute, Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical College, Dongguan 523808, China.
authors.forename: Xinxin
authors.initials: X
authors.lastname: Wang
authors.affiliation: China-America Cancer Research Institute, Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical College, Dongguan 523808, China.
authors.forename: Baohua
authors.initials: B
authors.lastname: Zhu
authors.affiliation: China-America Cancer Research Institute, Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical College, Dongguan 523808, China.
authors.forename: Zunnan
authors.initials: Z
authors.lastname: Huang
authors.affiliation: China-America Cancer Research Institute, Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical College, Dongguan 523808, China.
authors.forename: Liyong
authors.initials: L
authors.lastname: Chen
authors.affiliation: China-America Cancer Research Institute, Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical College, Dongguan 523808, China.
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: He
authors.affiliation: China-America Cancer Research Institute, Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical College, Dongguan 523808, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
keywords: MicroRNA (miRNAs); biomarker; leukemia