title: Relationship between duration of untreated psychosis and neurocognition and social cognition in first-episode psychosis.
abstract: Cognitive impairment is common in first-episode psychosis (FEP); however, the relationship between duration of untreated psychosis (DUP) and neurocognition remains controversial, and no studies have examined the relationship between DUP and social cognition. This study involved secondary data analysis of baseline data from a randomised controlled trial of supported employment; 122 out 146 young people with FEP met inclusion criteria for this study. Results showed that DUP was not associated with neurocognitive or social cognitive performance. Results do not provide support for the neurotoxicity hypothesis of psychosis.
authors.affiliation: Department of Psychology and Counselling, La Trobe University, Australia.
authors.forename: Zhi Xiang
authors.initials: ZX
authors.lastname: On
authors.affiliation: Orygen, The National Centre of Excellence in Youth Mental Health, Australia; Centre for Youth Mental Health, The University of Melbourne, Australia.
authors.forename: Susan
authors.initials: S
authors.lastname: Cotton
authors.affiliation: Department of Psychology and Counselling, La Trobe University, Australia.
authors.forename: John
authors.initials: J
authors.lastname: Farhall
authors.affiliation: Orygen, The National Centre of Excellence in Youth Mental Health, Australia; Centre for Youth Mental Health, The University of Melbourne, Australia.
authors.forename: Eóin
authors.initials: E
authors.lastname: Killackey
authors.affiliation: Orygen, The National Centre of Excellence in Youth Mental Health, Australia; Centre for Youth Mental Health, The University of Melbourne, Australia. Electronic address: kelly.allott@orygen.org.au.
authors.forename: Kelly
authors.initials: K
authors.lastname: Allott
mesh_terms: D000293:Adolescent; D000328:Adult; D003071:Cognition; D003072:Cognition Disorders / Q000209:etiology; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D007360:Intelligence; D008297:Male; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000150:complications / Q000523:psychology* / Q000628:therapy*; D012044:Regression Analysis; D012559:Schizophrenia / Q000150:complications / Q000628:therapy; D012565:Schizophrenic Psychology; D012919:Social Behavior; D061665:Time-to-Treatment; D055815:Young Adult
keywords: Duration of untreated psychosis (DUP); First-episode psychosis (FEP); Neurocognition; Neurotoxicity hypothesis; Social cognition