title: Pharmacologic Issues in Liver Disease.
abstract: This article describes key concepts for drug dosing considerations in liver disease. Included in this article is a review of pharmacokinetic changes that are known to occur in patients with liver disease that can aide in drug dosing. Although limited, the currently available pharmacokinetic data for medications that are commonly used in the critical care setting are also included.
authors.affiliation: Department of Pharmaceutical Services, Emory University Hospital, 1364 Clifton Road, Northeast, Atlanta, GA 30322, USA; Mercer University College of Pharmacy, Atlanta, GA.
authors.forename: Jolie
authors.initials: J
authors.lastname: Gallagher
authors.affiliation: Concordia University of Wisconsin School of Pharmacy, 12800 North Lake Shore Drive, Mequon, WI 53097, USA.
authors.forename: Annie N
authors.initials: AN
authors.lastname: Biesboer
authors.affiliation: Department of Pharmaceutical Services, Emory University Hospital, 1364 Clifton Road, Northeast, Atlanta, GA 30322, USA. Electronic address: alley.killian@emoryhealthcare.org.
authors.forename: Alley J
authors.initials: AJ
authors.lastname: Killian
mesh_terms: D000700:Analgesics / Q000378:metabolism / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000378:metabolism / Q000494:pharmacology; D000925:Anticoagulants / Q000378:metabolism / Q000494:pharmacology*; D000927:Anticonvulsants / Q000378:metabolism / Q000494:pharmacology*; D000932:Antiemetics / Q000008:administration & dosage / Q000378:metabolism; D002317:Cardiovascular Agents / Q000378:metabolism / Q000494:pharmacology*; D058625:End Stage Liver Disease / Q000503:physiopathology*; D006635:Histamine H2 Antagonists / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D017114:Liver Failure, Acute / Q000503:physiopathology*; D054328:Proton Pump Inhibitors / Q000378:metabolism / Q000494:pharmacology
chemical_list: D000700:Analgesics; D000890:Anti-Infective Agents; D000925:Anticoagulants; D000927:Anticonvulsants; D000932:Antiemetics; D002317:Cardiovascular Agents; D006635:Histamine H2 Antagonists; D054328:Proton Pump Inhibitors
keywords: Critical illness; Drug dosing; Liver disease; Pharmacokinetics; Pharmacology