title: Construction of Chiral Tri- and Tetra-Arylmethanes Bearing Quaternary Carbon Centers: Copper-Catalyzed Enantioselective Propargylation of Indoles with Propargylic Esters.
abstract: Copper-catalyzed enantioselective propargylation of indoles with propargylic esters and sequential Huisgen cycloaddition with azides lead to the construction of chiral triarylmethanes, bearing a quaternary carbon center, with high to excellent enantioselectivities. The result described herein can be used in the enantioselective preparation of a tetraarylmethane.
authors.affiliation: Department of Systems Innovation, School of Engineering, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.
authors.forename: Kouhei
authors.initials: K
authors.lastname: Tsuchida
authors.affiliation: Department of Systems Innovation, School of Engineering, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Senda
authors.affiliation: Department of Systems Innovation, School of Engineering, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.
authors.forename: Kazunari
authors.initials: K
authors.lastname: Nakajima
authors.affiliation: Department of Systems Innovation, School of Engineering, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan. ynishiba@sys.t.u-tokyo.ac.jp.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Nishibayashi
keywords: alkynes; copper; cycloadditions; enantioselectivity; synthetic methods