title: Thiol Redox and pKa Properties of Mycothiol, the Predominant Low-Molecular-Weight Thiol Cofactor in the Actinomycetes.
abstract: The thiol pKa and standard redox potential of mycothiol, the major low-molecular-weight thiol cofactor in the actinomycetes, are reported. The measured standard redox potential reveals substantial discrepancies in one or more of the other previously measured intracellular parameters that are relevant to mycothiol redox biochemistry.
authors.affiliation: School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.
authors.forename: Sunil V
authors.initials: SV
authors.lastname: Sharma
authors.affiliation: Department of Structural Biology, VIB, 1050, Brussels, Belgium.|Structural Biology Brussels, Vrije Universiteit Brussel, 1050, Brussels, Belgium.|Brussels Centre for Redox Biology, 1050, Brussels, Belgium.|Division of Redox Regulation, German Cancer Research Centre (DKFZ), Im Neuenheimer Feld 280, 69121, Heidelberg, Germany.
authors.forename: Koen
authors.initials: K
authors.lastname: Van Laer
authors.affiliation: Department of Structural Biology, VIB, 1050, Brussels, Belgium.|Structural Biology Brussels, Vrije Universiteit Brussel, 1050, Brussels, Belgium.|Brussels Centre for Redox Biology, 1050, Brussels, Belgium.
authors.forename: Joris
authors.initials: J
authors.lastname: Messens
authors.affiliation: School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK. c.hamilton@uea.ac.uk.
authors.forename: Chris J
authors.initials: CJ
authors.lastname: Hamilton
mesh_terms: D039903:Actinobacteria / Q000737:chemistry / Q000378:metabolism*; D003067:Coenzymes / Q000737:chemistry / Q000378:metabolism*; D003545:Cysteine / Q000737:chemistry* / Q000378:metabolism*; D006020:Glycopeptides / Q000737:chemistry* / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D007294:Inositol / Q000737:chemistry* / Q000378:metabolism*; D008968:Molecular Conformation; D008970:Molecular Weight; D010084:Oxidation-Reduction; D013438:Sulfhydryl Compounds / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D003067:Coenzymes; D006020:Glycopeptides; D013438:Sulfhydryl Compounds; C089265:mycothiol; D007294:Inositol; D003545:Cysteine
keywords: LMW thiols; acidity; mycothiol; redox chemistry; thiol pKa