title: Expression and clinicopathological correlations of retinoid acid receptor responder protein 1 in renal cell carcinomas.
abstract: OBJECTIVE
  To evaluate the expression and prognostic value of RARRES1 at protein level in renal cell carcinoma (RCC).
  
  
  METHODS
  Expression profile of RARRES1 was analyzed in 903 documented RCC followed by clinicopathological correlations and survival analysis.
  
  
  RESULTS
  RARRES1 expression was seen in 72.5% of RCC. A stronger RARRES1 expression was seen in high grade compared with low grade RCC (p < 0.001). Logrank tests revealed shorter overall survival in RARRES1 positive RCC (p = 0.006) and in pT1/2 tumors with RARRES1 expression (p = 0.002).
  
  
  CONCLUSIONS
  The variable expression profile in low and high grade RCC may reflect and confirm the differences of previous gene expression analysis. There was a significant prognostic value of RARRES1 expression in patients with RCC, especially in pT1/2 tumors.
authors.affiliation: Institute of Pathology, University Medicine Rostock, Strempelstr. 14, 18055 Rostock, Germany.|Institute of Pathology, University Hospital of Jena, Ziegelmühlenweg 1, 07743 Jena, Germany.
authors.forename: Annette
authors.initials: A
authors.lastname: Zimpfer
authors.affiliation: Institute of Pathology, University Medicine Rostock, Strempelstr. 14, 18055 Rostock, Germany.
authors.forename: Friedericke
authors.initials: F
authors.lastname: Dammert
authors.affiliation: Institute of Biostatistics, University of Rostock, Ernst-Heydemann-Str. 8, 18057 Rostock, Germany.
authors.forename: Aenne
authors.initials: A
authors.lastname: Glass
authors.affiliation: Clinical Cancer Registry, University Medicine Rostock, Südring 75, 18059 Rostock, Germany.
authors.forename: Heike
authors.initials: H
authors.lastname: Zettl
authors.affiliation: Institute of Pathology, Charité University Medicine, Chariteplatz 1, 10177 Berlin Germany.
authors.forename: Ergin
authors.initials: E
authors.lastname: Kilic
authors.affiliation: Clinic of Urology, HELIOS Hanseklinikum Stralsund, Große Parower Straße 47-53, 18435 Stralsund, Germany.|Clinic of Urology, University Medicine Rostock, Ernst-Heydemann-Str. 8, 18057 Rostock, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Maruschke
authors.affiliation: Clinic of Urology, University Medicine Rostock, Ernst-Heydemann-Str. 8, 18057 Rostock, Germany.
authors.forename: Oliver W
authors.initials: OW
authors.lastname: Hakenberg
authors.affiliation: Institute of Pathology, University Medicine Rostock, Strempelstr. 14, 18055 Rostock, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Erbersdobler
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D002292:Carcinoma, Renal Cell / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D060787:Neoplasm Grading; D016016:Proportional Hazards Models; D015996:Survival Rate; D046888:Tissue Array Analysis; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D008565:Membrane Proteins; C452562:RARRES1 protein, human
keywords: RARRES1; immunohistochemistry; renal cell carcinoma; retinoid acid responder protein 1; survival; tissue microarray