title: Synthesis of 2-Keto-d- and l-gluconic Acid via Stereoselective Direct Aldol Reactions.
abstract: Stereoselective direct aldol reaction between optically pure d- or l-glyceraldehyde and hydroxyacetylfuran is demonstrated as an efficient and straightforward methodology for the synthesis of six-carbon atom d- and l-arabino-hex-2-ulosonic acids. syn-Selective aldol reactions realized by using either tertiary amines or a dizinc aldol catalyst constitute two parallel routes to the de novo synthesis of orthogonally protected biologically relevant 2-keto-d- and l-gluconic acids.
authors.affiliation: Faculty of Chemistry, Jagiellonian University , Ingardena 3, 30-060 Krakow, Poland.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Baś
authors.affiliation: Faculty of Chemistry, Jagiellonian University , Ingardena 3, 30-060 Krakow, Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Mlynarski