title: Tandem Catalysis of an Aldol-'Click' Reaction System within a Molecular Hydrogel.
abstract: A heterogeneous supramolecular catalytic system for multicomponent aldol-'click' reactions is reported. The copper(I) metallohydrogel functionalized with a phenyltriazole fragment was able to catalyze the multicomponent reaction between phenylacetylene, p-nitrobenzaldehyde, and an azide containing a ketone moiety, obtaining the corresponding aldol products in good yields. A possible mechanistic pathway responsible for this unexpected catalytic behavior has been proposed.
authors.affiliation: Departament de Qu&#237;mica Inorg&#224;nica i Org&#224;nica, Universitat Jaume I, 12071 Castell&#243;, Spain. cerqueir@uji.es.
authors.forename: Marco
authors.initials: M
authors.lastname: Araújo
authors.affiliation: Departament de Qu&#237;mica Inorg&#224;nica i Org&#224;nica, Universitat Jaume I, 12071 Castell&#243;, Spain. munozi@uji.es.
authors.forename: Iván
authors.initials: I
authors.lastname: Muñoz Capdevila
authors.affiliation: Departament de Qu&#237;mica Inorg&#224;nica i Org&#224;nica, Universitat Jaume I, 12071 Castell&#243;, Spain. sdiaz@uji.es.
authors.forename: Santiago
authors.initials: S
authors.lastname: Díaz-Oltra
authors.affiliation: Departament de Qu&#237;mica Inorg&#224;nica i Org&#224;nica, Universitat Jaume I, 12071 Castell&#243;, Spain. escuder@uji.es.
authors.forename: Beatriu
authors.initials: B
authors.lastname: Escuder
mesh_terms: D000114:Acetylene / Q000031:analogs & derivatives / Q000737:chemistry; D000447:Aldehydes / Q000737:chemistry; D001386:Azides / Q000737:chemistry; D001547:Benzaldehydes / Q000737:chemistry; D002384:Catalysis; D057930:Click Chemistry; D003300:Copper / Q000737:chemistry; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D008670:Metals / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D001386:Azides; D001547:Benzaldehydes; D007659:Ketones; D008670:Metals; C044736:phenylacetylene; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D003300:Copper; C116609:3-hydroxybutanal; D000114:Acetylene; C032175:benzaldehyde
keywords: aldol addition; click reaction; multicomponent system; supramolecular gels; tandem catalysis