title: Spontaneous intracranial hypotension syndrome: contribution of radioisotope cisternography.
abstract: Spontaneous intracranial hypotension is a clinical syndrome caused by a loss of cerebrospinal fluid volume, usually secondary to leaking through structural defects of the spinal dura mater. Radioisotope cisternography (RC) can confirm the diagnosis of spontaneous intracranial hypotension, especially in doubtful or atypical case presentations. A retrospective study was conducted on 8 patients who underwent RC because spontaneous intracranial hypotension was suspected, and they presented with atypical clinical manifestations and/or inconclusive findings in other imaging techniques. RC detected paradural extravasation of cerebrospinal fluid in 7 patients. Moreover, there was indirect evidence of cerebrospinal fluid leaks in all 8 patients (early appearance of radioactivity in the bladder, soft tissue uptake of radioisotope and/or reduction in the amount of radiotracer in the brain at 24hours). RC had a significant impact on the diagnosis of 6 patients, and on the therapeutic management of 4 patients.
authors.affiliation: Servicio de Medicina Nuclear, Hospital San Pedro de Alcántara, Cáceres, España. Electronic address: juanpablosuarez@yahoo.es.
authors.forename: J P
authors.initials: JP
authors.lastname: Suárez
authors.affiliation: Servicio de Medicina Nuclear, Hospital San Pedro de Alcántara, Cáceres, España.
authors.forename: M L
authors.initials: ML
authors.lastname: Domínguez
authors.affiliation: Servicio de Medicina Nuclear, Hospital San Pedro de Alcántara, Cáceres, España.
authors.forename: M A
authors.initials: MA
authors.lastname: Gómez
authors.affiliation: Servicio de Medicina Nuclear, Complejo Hospitalario Universitario de Orense, Orense, España.
authors.forename: J L
authors.initials: JL
authors.lastname: Muñoz
mesh_terms: D000328:Adult; D065634:Cerebrospinal Fluid Leak / Q000150:complications / Q000000981:diagnostic imaging; D002559:Cerebrospinal Fluid Rhinorrhea / Q000209:etiology; D002946:Cisterna Magna / Q000000981:diagnostic imaging*; D006259:Craniocerebral Trauma / Q000150:complications; D004388:Dura Mater / Q000293:injuries; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes / Q000493:pharmacokinetics; D019585:Intracranial Hypotension / Q000000981:diagnostic imaging* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D059906:Neuroimaging / Q000379:methods*; D004369:Pentetic Acid / Q000493:pharmacokinetics; D011877:Radionuclide Imaging / Q000379:methods*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D012189:Retrospective Studies; D012422:Rupture, Spontaneous
chemical_list: D007205:Indium Radioisotopes; D019275:Radiopharmaceuticals; D004369:Pentetic Acid; C000615551:Indium-111
keywords: Cerebrospinal fluid leak; Cisternografía radioisotópica; Fuga de líquido cefalorraquídeo; Hipotensión intracraneal; Intracranial hypotension; Radioisotope cisternography