title: Predictors of low estimated glomerular filtration rate after living kidney donation in a Southeast Asian population from Singapore.
abstract: OBJECTIVE
  Post-donation kidney function has not been well characterized in the Southeast Asian population. We studied a retrospective cohort of 174 living kidney donors at Singapore General Hospital between 1976 and 2012, evaluated patterns of change in kidney function using quantile regression analysis and investigated for predictors of low estimated glomerular filtration rate (eGFR) < 60 mL/min per 1.73m2. Median follow-up time (range) was 7.8 (0.1-33.8) years following donor nephrectomy.
  
  
  RESULTS
  Of the donors, 43.1% regained 75% or more of pre-nephrectomy eGFR after 5 years post-donation; 9.8% exhibited 100% recovery to pre-nephrectomy eGFR. High pre-nephrectomy eGFR was protective for risk of low post-donation eGFR, with a 6% risk reduction for each unit increase in pre-nephrectomy eGFR (odds ratio, 0.94; 95% confidence interval, 0.91-0.97; P = 0.002). This relationship was stronger in the short term (>6 months to < 5 years) than medium to long term (5 years or longer) (interaction P = 0.052).
  
  
  CONCLUSIONS
  In general, kidney function is well preserved following kidney donation in Southeast Asian donors. Pre-nephrectomy eGFR is a good predictor of post-donation eGFR, especially in the short-term.
authors.affiliation: Department of Renal Medicine, Singapore General Hospital, Singapore.
authors.forename: Ru Yu
authors.initials: RY
authors.lastname: Tan
authors.affiliation: Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore.
authors.forename: John C
authors.initials: JC
authors.lastname: Allen
authors.affiliation: Department of Renal Medicine, Singapore General Hospital, Singapore.
authors.forename: Terence
authors.initials: T
authors.lastname: Kee
authors.affiliation: Department of Renal Medicine, Singapore General Hospital, Singapore.|Health Services and Systems Research, Duke-NUS Graduate Medical School, Singapore.
authors.forename: Tazeen H
authors.initials: TH
authors.lastname: Jafar
mesh_terms: D000328:Adult; D044466:Asian People; D005260:Female; D005919:Glomerular Filtration Rate; D006304:Health Status; D006769:Hospitals, General; D006801:Humans; D007668:Kidney / Q000503:physiopathology / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects / Q000379:methods*; D019520:Living Donors; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009392:Nephrectomy / Q000009:adverse effects; D016017:Odds Ratio; D020127:Recovery of Function; D012189:Retrospective Studies; D012307:Risk Factors; D012846:Singapore; D013997:Time Factors; D016896:Treatment Outcome
keywords: glomerular filtration rate; kidney transplantation; living donor transplantation