title: Cervical Vertebral Body's Volume as a New Parameter for Predicting the Skeletal Maturation Stages.
abstract: This study aimed to determine the correlation between the volumetric parameters derived from the images of the second, third, and fourth cervical vertebrae by using cone beam computed tomography with skeletal maturation stages and to propose a new formula for predicting skeletal maturation by using regression analysis. We obtained the estimation of skeletal maturation levels from hand-wrist radiographs and volume parameters derived from the second, third, and fourth cervical vertebrae bodies from 102 Japanese patients (54 women and 48 men, 5-18 years of age). We performed Pearson's correlation coefficient analysis and simple regression analysis. All volume parameters derived from the second, third, and fourth cervical vertebrae exhibited statistically significant correlations (P < 0.05). The simple regression model with the greatest R-square indicated the fourth-cervical-vertebra volume as an independent variable with a variance inflation factor less than ten. The explanation power was 81.76%. Volumetric parameters of cervical vertebrae using cone beam computed tomography are useful in regression models. The derived regression model has the potential for clinical application as it enables a simple and quantitative analysis to evaluate skeletal maturation level.
authors.affiliation: Department of Orthodontics, Biomedical Research Institute, Pusan National University Hospital, Gudeokro 179, Busan 602739, Republic of Korea.
authors.forename: Youn-Kyung
authors.initials: YK
authors.lastname: Choi
authors.affiliation: Department of Biostatistics, Clinical Trial Center, Pusan National University Hospital, Busan 602739, Republic of Korea.
authors.forename: Jinmi
authors.initials: J
authors.lastname: Kim
authors.affiliation: Department of Orthodontics, School of Dentistry, Showa University, Tokyo 1458515, Japan.
authors.forename: Tetsutaro
authors.identifier: 0000-0001-9806-7163
authors.initials: T
authors.lastname: Yamaguchi
authors.affiliation: Department of Orthodontics, School of Dentistry, Showa University, Tokyo 1458515, Japan.
authors.forename: Koutaro
authors.initials: K
authors.lastname: Maki
authors.affiliation: Department of Orthodontics, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA.
authors.forename: Ching-Chang
authors.initials: CC
authors.lastname: Ko
authors.affiliation: Department of Orthodontics, Biomedical Research Institute, Pusan National University Hospital, Gudeokro 179, Busan 602739, Republic of Korea; Dental Research Institute, Pusan National University Dental Hospital, Yangsan 626787, Republic of Korea; Institute of Translational Dental Sciences, Pusan National University, Busan 602739, Republic of Korea.
authors.forename: Yong-Il
authors.identifier: 0000-0003-3889-2545
authors.initials: YI
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D001846:Bone Development; D002574:Cervical Vertebrae / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D002648:Child; D002675:Child, Preschool; D054893:Cone-Beam Computed Tomography; D005260:Female; D006801:Humans; D008297:Male; D009929:Organ Size; D012044:Regression Analysis