title: Surrogate endpoints and competing risk of death in cardiac arrest research.
abstract: We urgently need new therapies to improve outcomes after cardiac arrest. Initial studies typically target surrogate endpoints, and these studies help to inform subsequent larger trials that are powered to measure more patient-orientated clinical outcomes such as survival. The competing risk of death and premature assessment of neurological prognosis pose significant challenges to measuring these surrogate endpoints after cardiac arrest.
authors.affiliation: Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Room D108, Toronto, ON, M4N 3M5, Canada. victoria.mccredie@sunnybrook.ca.|Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada. victoria.mccredie@sunnybrook.ca.|Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada. victoria.mccredie@sunnybrook.ca.
authors.forename: Victoria A
authors.initials: VA
authors.lastname: McCredie
authors.affiliation: Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Room D108, Toronto, ON, M4N 3M5, Canada.|Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada.|Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Damon C
authors.initials: DC
authors.lastname: Scales
mesh_terms: D015415:Biomarkers; D003643:Death; D006323:Heart Arrest; D006801:Humans; D011379:Prognosis; D012306:Risk
chemical_list: D015415:Biomarkers