title: Microenvironmental InterFereNce of metabolism regulates chemosensitivity.
abstract: The tumor microenvironment is recognized as a critical regulator of cancer progression, and multiple roles are also emerging for the microenvironment in modulating response to therapeutic intervention. A recent study by Wang and colleagues identified IFN-γ as a central effector of CD8 T cell-mediated regulation of glutathione and cysteine metabolism in fibroblasts, which consequently abrogates stromal-induced resistance through modulation of cisplatin intracellular content in ovarian cancer cells.
authors.affiliation: Ludwig Institute for Cancer Research, Lausanne, Switzerland.|Department of Oncology, University of Lausanne, Lausanne, Switzerland.
authors.forename: Leila
authors.initials: L
authors.lastname: Akkari
authors.affiliation: Ludwig Institute for Cancer Research, Lausanne, Switzerland.|Department of Oncology, University of Lausanne, Lausanne, Switzerland.
authors.forename: Johanna A
authors.initials: JA
authors.lastname: Joyce
mesh_terms: D002945:Cisplatin; D019008:Drug Resistance, Neoplasm; D005260:Female; D005978:Glutathione; D006801:Humans; D010051:Ovarian Neoplasms; D013601:T-Lymphocytes; D059016:Tumor Microenvironment
chemical_list: D005978:Glutathione; D002945:Cisplatin