title: Targeting the blood-spinal cord barrier: A therapeutic approach to spinal cord protection against ischemia-reperfusion injury.
abstract: One of the principal functions of physical barriers between the blood and central nervous system protects system (i.e., blood brain barrier and blood-spinal cord barrier) is the protection from toxic and pathogenic agents in the blood. Disruption of blood-spinal cord barrier (BSCB) plays a key role in spinal cord ischemia-reperfusion injury (SCIRI). Following SCIRI, the permeability of the BSCB increases. Maintaining the integrity of the BSCB alleviates the spinal cord injury after spinal cord ischemia. This review summarizes current knowledge of the structure and function of the BSCB and its changes following SCIRI, as well as the prevention and cure of SCIRI and the role of the BSCB.
authors.affiliation: Department of Anesthesiology, Liyuan Hospital of Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430077, Hubei Province, China. Electronic address: yqj2566@sina.com.
authors.forename: Ji
authors.initials: J
authors.lastname: Hu
authors.affiliation: Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China. Electronic address: yqj721103@sina.com.
authors.forename: Qijing
authors.initials: Q
authors.lastname: Yu
authors.affiliation: Department of Anesthesiology, Liyuan Hospital of Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430077, Hubei Province, China.
authors.forename: Lijie
authors.initials: L
authors.lastname: Xie
authors.affiliation: Department of Anesthesiology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, Hubei Province, China.
authors.forename: Hongfei
authors.initials: H
authors.lastname: Zhu
mesh_terms: D006801:Humans; D019194:Ischemic Preconditioning; D020760:Spinal Cord Ischemia / Q000517:prevention & control*
keywords: Blood-spinal cord barrier; Reperfusion injury; Spinal cord ischemia