title: Treatment of Hepatitis C Virus Infection in Liver Transplant Recipients.
abstract: Chronic hepatitis C virus (HCV) infection is the leading cause of liver transplantation in adults. Although the recurrence of HCV infection after liver transplantation is nearly universal, the recent advances in direct-acting antiviral (DAA) agents have revolutionized the management of HCV infection in the posttransplant setting. A number of these agents have been evaluated in recent clinical trials and have shown high sustained virologic response rates, shorter durations of treatment, and decreased adverse events when compared with the previous treatment of pegylated interferon and ribavirin. This article will review the current literature on the efficacy, tolerability, and potential drug interactions of various DAA agents in patients with recurrent HCV infection posttransplant.
authors.affiliation: Dr Suraweera is a resident in the Department of Medicine at Olive-View Medical Center in Sylmar, California. Dr Sundaram is an assistant professor of medicine at Cedars-Sinai Medical Center in Los Angeles, California. Dr Saab is a professor of medicine and surgery at the University of California at Los Angeles in Los Angeles, California.
authors.forename: Duminda
authors.initials: D
authors.lastname: Suraweera
authors.affiliation: Dr Suraweera is a resident in the Department of Medicine at Olive-View Medical Center in Sylmar, California. Dr Sundaram is an assistant professor of medicine at Cedars-Sinai Medical Center in Los Angeles, California. Dr Saab is a professor of medicine and surgery at the University of California at Los Angeles in Los Angeles, California.
authors.forename: Vinay
authors.initials: V
authors.lastname: Sundaram
authors.affiliation: Dr Suraweera is a resident in the Department of Medicine at Olive-View Medical Center in Sylmar, California. Dr Sundaram is an assistant professor of medicine at Cedars-Sinai Medical Center in Los Angeles, California. Dr Saab is a professor of medicine and surgery at the University of California at Los Angeles in Los Angeles, California.
authors.forename: Sammy
authors.initials: S
authors.lastname: Saab
keywords: Hepatitis C virus; direct-acting antiviral agents; liver transplant; recurrence; viral hepatitis