title: Supra-Epiglottic Upper Airway Volume in Elderly Patients with Obstructive Sleep Apnea Hypopnea Syndrome.
abstract: OBJECTIVE
  Small upper airway measurements areas and high body mass index are recognized risk factors for obstructive sleep apnea syndrome (OSAS) in non-elderly populations; however, there is limited information regarding elderly patients. We evaluated whether upper airway volume is associated with OSAS and OSAS treated with continuous positive airway pressure (CPAP) treatment and whether BMI is correlated with upper airway volume and measurements in elderly subjects.
  
  
  METHODS
  In 60 volunteers aged 75.58±0.9 years: 20 OSAS, 20 OSAS chronically treated with CPAP, and 20 controls, semi-automatic segmentation, retropalatal distance and transverse diameter of the supra-epiglottic upper airway were evaluated using 3DT1-weighted magnetic resonance imaging. Anteroposterior to transverse diameter ratio was defined as retropalatar diameter/transverse diameter.
  
  
  RESULTS
  There were no significant differences in supra-epiglottic upper airway volume between OSAS, CPAP treated patients, and controls. There were significant differences in retropalatal distance and anteroposterior to transverse diameter ratio between OSAS, CPAP treated patients, and controls (P = 0.008 and P<0.0001 respectively). There was a significant correlation between body mass index and retropalatal distance (P<0.05) but not with supra-epiglottic upper airway volume.
  
  
  CONCLUSIONS
  In elderly subjects, OSAS and body mass index are not associated with changes in supra-epiglottic upper airway volume but are associated with modification of pharynx shape.
authors.affiliation: Inserm U1059, Univ Lyon, Department of Radiology, Pole IMOFON, CHU of Saint-Etienne, Saint-Etienne, France.
authors.forename: Claire
authors.identifier: http://orcid.org/0000-0001-9850-4124
authors.initials: C
authors.lastname: Boutet
authors.affiliation: Department of Radiology, Pole IMOFON, CHU of Saint-Etienne, Saint-Etienne, France.
authors.forename: Syad
authors.initials: S
authors.lastname: Abdirahman Mohamed Moussa
authors.affiliation: EA 4607 SNA EPIS, Clinical Physiology and VISAS Center, Pole NOL, CHU and Faculty of Medicine of Saint-Etienne, University Jean Monnet Saint-Etienne, COMUE Lyon Saint-Etienne, France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Celle
authors.affiliation: Neurology/Neuropsychology, Center Memory of Resources and Research Unit, Pain Center, North Saint-Etienne University Hospital Center, Central Integration of Pain, Lyon Neuroscience Research Center, Bron, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Laurent
authors.affiliation: EA 4607 SNA EPIS, Clinical Physiology and VISAS Center, Pole NOL, CHU and Faculty of Medicine of Saint-Etienne, University Jean Monnet Saint-Etienne, COMUE Lyon Saint-Etienne, France.
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Barthélémy
authors.affiliation: Department of Radiology, Pole IMOFON, CHU of Saint-Etienne, Saint-Etienne, France.
authors.forename: Fabrice-Guy
authors.initials: FG
authors.lastname: Barral
authors.affiliation: EA 4607 SNA EPIS, Clinical Physiology and VISAS Center, Pole NOL, CHU and Faculty of Medicine of Saint-Etienne, University Jean Monnet Saint-Etienne, COMUE Lyon Saint-Etienne, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Roche
mesh_terms: D000368:Aged; D015992:Body Mass Index; D015331:Cohort Studies; D045422:Continuous Positive Airway Pressure; D004825:Epiglottis / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D010614:Pharynx / Q000473:pathology; D012119:Respiration; D020181:Sleep Apnea, Obstructive / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy