title: Use and Cutaneous Side Effects of Skin Antiseptics in Extremely Low Birth Weight Infants - A Retrospective Survey of the German NICUs.
abstract: Background Nosocomial infections are a serious problem in the treatment of extremely low birth weight infants (ELBW, <1 000 g). In these patients, effective skin antisepsis is critical to prevent hospital-acquired infections and their sequelae. However, serious side effects of topical antiseptics have been repeatedly reported in extremely preterm infants and no agreement has been reached on the best product in this population. Therefore, we conducted a survey of the German NICUs aiming to investigate current practices and safety of topical antiseptics in ELBW neonates.
  
  
  METHODS
  We sent anonymized questionnaires to 166 German NICUs with the highest level of care.
  
  
  RESULTS
  Usable questionnaires were returned by 64 NICUs (39%). These NICUs had treated a total of 2130 patients with a birth weight<1 000 g in 2012. Octenidine without phenoxyethanol (OwPh) and Octenisept(®) were the predominantly used skin antiseptics for intensive-care procedures. At least one skin complication was reported by 27% (n=17) of the NICUs. In 9 cases Octenisept(®) was used, and in 6 cases octenidine was used.
  
  
  CONCLUSIONS
  According to our knowledge, this is the first study surveying practices and safety of skin antisepsis in ELBWs in the German NICUs. Most German NICUs use octenidine, however, in different preparations. Skin complications including blistering, necrosis and scarring were seen with all octenidine products, a fact which has not been previously reported.
authors.affiliation: Department of Neonatology and Paediatric Intensive Care, Childrens' Hospital, University of Cologne, Cologne, Germany.
authors.forename: C D
authors.initials: CD
authors.lastname: Biermann
authors.affiliation: Department of Neonatology and Paediatric Intensive Care, Childrens' Hospital, University of Cologne, Cologne, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Kribs
authors.affiliation: Department of Neonatology and Paediatric Intensive Care, Childrens' Hospital, University of Cologne, Cologne, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Roth
authors.affiliation: Dermatology, University of Cologne, Cologne, Germany.
authors.forename: I
authors.initials: I
authors.lastname: Tantcheva-Poor
mesh_terms: D000891:Anti-Infective Agents, Local / Q000009:adverse effects*; D003428:Cross Infection / Q000517:prevention & control*; D003875:Drug Eruptions / Q000209:etiology*; D005260:Female; D005858:Germany; D006801:Humans; D052577:Infant, Extremely Low Birth Weight; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000139:chemically induced*; D007363:Intensive Care Units, Neonatal; D008297:Male; D012189:Retrospective Studies; D011795:Surveys and Questionnaires
chemical_list: D000891:Anti-Infective Agents, Local