title: Application prospective of nanoprobes with MRI and FI dual-modality imaging on breast cancer stem cells in tumor.
abstract: Breast cancer (BC) is a serious disease to threat lives of women. Numerous studies have proved that BC originates from cancer stem cells (CSCs). But at present, no one approach can quickly and simply identify breast cancer stem cells (BCSCs) in solid tumor. Nanotechnology is probably able to realize this goal. But in study process, scientists find it seems that nanomaterials with one modality, such as magnetic resonance imaging (MRI) or fluorescence imaging (FI), have their own advantages and drawbacks. They cannot meet practical requirements in clinic. The nanoprobe combined MRI with FI modality is a promising tool to accurately detect desired cells with low amount in tissue. In this work, we briefly describe the MRI and FI development history, analyze advantages and disadvantages of nanomaterials with single modality in cancer cell detection. Then the application development of nanomaterials with dual-modality in cancer field is discussed. Finally, the obstacles and prospective of dual-modal nanoparticles in detection field of BCSCs are also pointed out in order to speed up clinical applications of nanoprobes.
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, No. 22, Qixiangtai Road, Heping District, Tianjin, 300070, China.
authors.forename: Hetao
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Chemistry, Qiqihaer Medical College, Qiqihaer, 161006, Heilongjiang Province, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, No. 22, Qixiangtai Road, Heping District, Tianjin, 300070, China.
authors.forename: Tong
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, No. 22, Qixiangtai Road, Heping District, Tianjin, 300070, China.
authors.forename: Dongxing
authors.initials: D
authors.lastname: Shi
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, No. 22, Qixiangtai Road, Heping District, Tianjin, 300070, China.
authors.forename: Zengrong
authors.initials: Z
authors.lastname: Sun
authors.affiliation: Department of Chemistry, Qiqihaer Medical College, Qiqihaer, 161006, Heilongjiang Province, China. chunhuixia1969@sohu.com.
authors.forename: Chunhui
authors.initials: C
authors.lastname: Xia
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, No. 22, Qixiangtai Road, Heping District, Tianjin, 300070, China. wbqpaper@126.com.
authors.forename: Baiqi
authors.initials: B
authors.lastname: Wang
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000235:genetics / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D003287:Contrast Media / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics; D005260:Female; D019786:Gadolinium DTPA / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics; D006801:Humans; D018796:Immunoconjugates / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics; D019394:Ki-67 Antigen / Q000235:genetics / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry / Q000378:metabolism; D014411:Neoplastic Stem Cells / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure*; D061848:Optical Imaging / Q000295:instrumentation / Q000379:methods*; D045663:Quantum Dots / Q000737:chemistry / Q000378:metabolism; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics / Q000378:metabolism
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D003287:Contrast Media; D019786:Gadolinium DTPA; D018796:Immunoconjugates; D019394:Ki-67 Antigen; D018719:Erb-b2 Receptor Tyrosine Kinases; C524056:Erbb2 protein, mouse
keywords: Breast cancer; Cancer stem cells; Fluorescence; Imaging; Magnetic resonance