title: Short Communication: HIV Controller T Cells Effectively Inhibit Viral Replication in Alveolar Macrophages.
abstract: Macrophages are targets of HIV-1 infection, and control of viral replication within these cells may be an important component of a T-cell-based vaccine. Although several studies have analyzed the ability of CD8+T cells to inhibit viral replication in monocyte-derived macrophages, the effect of T cells on HIV-1-infected tissue macrophages is less clear. We demonstrate here that both CD4+and CD8+T-cell effectors from HIV controllers are capable of suppressing viral replication in bronchoalveolar lavage-derived alveolar macrophages. These findings have implications for HIV-1 vaccine and eradication strategies.
authors.affiliation: 1 Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, Maryland.
authors.forename: Victoria E
authors.initials: VE
authors.lastname: Walker-Sperling
authors.affiliation: 1 Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, Maryland.
authors.forename: Christian A
authors.initials: CA
authors.lastname: Merlo
authors.affiliation: 1 Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, Maryland.
authors.forename: Robert W
authors.initials: RW
authors.lastname: Buckheit
authors.affiliation: 1 Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, Maryland.
authors.forename: Allison
authors.initials: A
authors.lastname: Lambert
authors.affiliation: 2 Division of Biostatistics and Epidemiology, Paul L. Foster School of Medicine , El Paso, Texas.
authors.forename: Patrick
authors.initials: P
authors.lastname: Tarwater
authors.affiliation: 1 Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, Maryland.
authors.forename: Greg D
authors.initials: GD
authors.lastname: Kirk
authors.affiliation: 1 Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, Maryland.
authors.forename: M Bradley
authors.initials: MB
authors.lastname: Drummond
authors.affiliation: 1 Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, Maryland.
authors.forename: Joel N
authors.initials: JN
authors.lastname: Blankson
mesh_terms: D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology* / Q000502:physiology; D006801:Humans; D016676:Macrophages, Alveolar / Q000821:virology*; D017741:Survivors; D014779:Virus Replication
keywords: CD8 T cells; CTL; alveolar macrophages; monocyte derived macrophages