title: A proline-derived transannular N-cap for nucleation of short α-helical peptides.
abstract: We report herein a proline-derived transannular N-cap as a helix nucleating template in diverse bio-related peptide sequences via macrolactamization on resin. This approach takes advantage of synergistic stabilization effects of both N-capping properties of proline and substitution of a main chain hydrogen bond with a covalent bond.
authors.affiliation: School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University, Shenzhen, 518055, China. lizg@pkusz.edu.cn.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Tian
authors.forename: Dongyuan
authors.initials: D
authors.lastname: Wang
authors.forename: Jingxu
authors.initials: J
authors.lastname: Li
authors.forename: Chuan
authors.initials: C
authors.lastname: Shi
authors.forename: Hui
authors.initials: H
authors.lastname: Zhao
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Niu
authors.forename: Zigang
authors.initials: Z
authors.lastname: Li
mesh_terms: D006860:Hydrogen Bonding; D008968:Molecular Conformation; D010455:Peptides / Q000737:chemistry*; D011392:Proline / Q000737:chemistry*; D017433:Protein Structure, Secondary
chemical_list: D010455:Peptides; D011392:Proline