title: Data on TREM-1 activation destabilizing carotid plaques.
abstract: The data described herein are related to the article entitled "Tumor necrosis factor-α regulates triggering receptor expressed on myeloid cells-1-dependent matrix metalloproteinases in the carotid plaques of symptomatic patients with carotid stenosis" (Rao et al., 2016) [1]. Additional data are provided on the dose-response effect of TNF-α, TREM-1 antibody and recombinant rTREM-1/Fc fusion chimera (TREM-1/FC) on the expression of MMP-1 and MMP-9 in vascular smooth muscle cells (VSMCs) isolated from human carotid endarterectomy tissues. Data are also presented on the distribution of CD86+ M1- and CD206+ M2-macrophages and their co-localization with TREM-1 in symptomatic carotid plaques as visualized by dual immunofluorescence. The interpretation of this data and further extensive insights can be found in Rao et al. (2016) [1].
authors.affiliation: Department of Clinical and Translational Science, Creighton University School of Medicine, Omaha, NE 68178, United States.
authors.forename: Velidi H
authors.initials: VH
authors.lastname: Rao
authors.affiliation: Department of Clinical and Translational Science, Creighton University School of Medicine, Omaha, NE 68178, United States.
authors.forename: Vikrant
authors.initials: V
authors.lastname: Rai
authors.affiliation: Department of Clinical and Translational Science, Creighton University School of Medicine, Omaha, NE 68178, United States.
authors.forename: Samantha
authors.initials: S
authors.lastname: Stoupa
authors.affiliation: Department of Clinical and Translational Science, Creighton University School of Medicine, Omaha, NE 68178, United States.
authors.forename: Saravanan
authors.initials: S
authors.lastname: Subramanian
authors.affiliation: Department of Clinical and Translational Science, Creighton University School of Medicine, Omaha, NE 68178, United States.
authors.forename: Devendra K
authors.initials: DK
authors.lastname: Agrawal
keywords: Atherosclerosis; Carotid plaques; Macrophages; Matrix metalloproteinases; Triggering receptor expressed on myeloid cells-1; Unstable plaque; Vascular smooth muscle cells; Vulnerable plaque