title: Effect of mid-luteal phase GnRH agonist on frozen-thawed embryo transfers during natural menstrual cycles: a randomised clinical pilot study.
abstract: This prospective randomised crossover study evaluated the effect of mid-luteal single-dose gonadotropin-releasing hormone agonist (triptoreline) on pregnancy outcomes in natural-cycle frozen embryo transfers (FETs). Ninety-eight women were randomised to receive either standard luteal support with vaginal micronised progesterone or an additional single dose of 0.1 mg triptoreline at the time of implantation. The intervention group was composed of 65 FET cycles and the control group of 62 cycles. In the intervention group, there were more positive pregnancy tests, clinical pregnancies and live births, but the differences did not reach statistical significance. The mean beta human chorionic gonadotropin (β-hCG) concentration of singleton pregnancies was significantly lower in the intervention group compared to the control group (p = 0.048). No difference was detected in the median birth weight of the newborns.
authors.affiliation: a Department of Obstetrics and Gynecology , Central Ostrobothnia Central Hospital , Kokkola , Finland.|b Department of Obstetrics and Gynecology , Turku University Hospital and University of Turku , Turku , Finland.
authors.forename: Jaana
authors.initials: J
authors.lastname: Seikkula
authors.affiliation: c Väestöliitto Fertility Clinic , Turku , Finland.
authors.forename: Leena
authors.initials: L
authors.lastname: Anttila
authors.affiliation: b Department of Obstetrics and Gynecology , Turku University Hospital and University of Turku , Turku , Finland.
authors.forename: Päivi
authors.initials: P
authors.lastname: Polo-Kantola
authors.affiliation: d Medical Informatics and Statistics Research Group, University of Oulu , Oulu , Finland.
authors.forename: Risto
authors.initials: R
authors.lastname: Bloigu
authors.affiliation: e Department of Mathematics and Statistics , University of Turku , Turku , Finland , and.
authors.forename: Janne
authors.initials: J
authors.lastname: Engblom
authors.affiliation: f Department of Obstetrics and Gynecology , Tampere University Hospital and University of Tampere , Tampere , Finland.
authors.forename: Helena
authors.initials: H
authors.lastname: Tinkanen
authors.affiliation: b Department of Obstetrics and Gynecology , Turku University Hospital and University of Turku , Turku , Finland.
authors.forename: Varpu
authors.initials: V
authors.lastname: Jokimaa
mesh_terms: D000328:Adult; D018592:Cross-Over Studies; D015925:Cryopreservation; D004624:Embryo Transfer / Q000379:methods*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006801:Humans; D008183:Luteal Phase / Q000187:drug effects; D008186:Luteolytic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D017063:Outcome Assessment, Health Care; D010865:Pilot Projects; D011247:Pregnancy; D011256:Pregnancy Outcome; D011374:Progesterone / Q000008:administration & dosage / Q000494:pharmacology*; D011446:Prospective Studies; D017329:Triptorelin Pamoate / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D008186:Luteolytic Agents; D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone
keywords: Clinical pregnancy; frozen-thawed embryo transfer; gonadotropin releasing hormone agonist; live birth rate; luteal support; slow freezing