title: Chronic hepatitis C virus infection and the risk for diabetes: a community-based prospective study.
abstract: The association between hepatitis C virus (HCV) infection and the occurrence of type II diabetes remains controversial. Prospective studies are needed to assess its causal temporality.
  
  
  
  A cohort of 21 559 adults enrolled from seven townships in Taiwan during 1991-1992 and followed till the end of 2010. Incident diabetes over a study time period from 2000 to 2010 was ascertained through computerized linkage with the National Health Insurance database and the National Death Certification profiles. Cox's proportional hazards models were used to estimate hazard ratios (HRs) with 95% confidence intervals (CIs). Antibodies against HCV (anti-HCV) were tested for all participants, and serum HCV RNA levels were measured for anti-HCV seropositives.
  
  
  
  During 180 244 person-years of follow-up, there were 1917 incident diabetes cases recorded. The cumulative risk for diabetes was 10.9% for anti-HCV seronegatives and 16.7% for anti-HCV seropositives respectively. The HR for diabetes of anti-HCV seropositivity was 1.53 (95% CI: 1.29-1.81) compared with anti-HCV seronegatives after adjustment for risk predictors. The adjusted HRs were 1.63 (1.31-2.02) for anti-HCV seropositives with positive HCV RNA compared to anti-HCV seronegatives (P<.001).
  
  
  
  Chronic HCV infection was associated with an increased risk for diabetes after adjustment for other risk predictors.
authors.affiliation: Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Yu-Ju
authors.initials: YJ
authors.lastname: Lin
authors.affiliation: Genomics Research Center, Academia Sinica, Taipei, Taiwan.
authors.forename: Tzun-Wen G
authors.initials: TG
authors.lastname: Shaw
authors.affiliation: Genomics Research Center, Academia Sinica, Taipei, Taiwan.
authors.forename: Hwai-I
authors.initials: HI
authors.lastname: Yang
authors.affiliation: Division of Hepato-Gastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.|Chang Gung University School of Medicine, Kaohsiung, Taiwan.
authors.forename: Sheng-Nan
authors.initials: SN
authors.lastname: Lu
authors.affiliation: Genomics Research Center, Academia Sinica, Taipei, Taiwan.
authors.forename: Chin-Lan
authors.initials: CL
authors.lastname: Jen
authors.affiliation: MacKay Medical College, New Taipei City, Taiwan.
authors.forename: Li-Yu
authors.initials: LY
authors.lastname: Wang
authors.affiliation: Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Kang-Hsuan
authors.initials: KH
authors.lastname: Wong
authors.affiliation: Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Soa-Yu
authors.initials: SY
authors.lastname: Chan
authors.affiliation: Global Health Economics and Outcomes Research, Bristol-Myers Squibb, Princeton, NJ, USA.
authors.forename: Yong
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Gilber
authors.initials: G
authors.lastname: L'Italien
authors.affiliation: Genomics Research Center, Academia Sinica, Taipei, Taiwan.|Academia Sinica, Taipei, Taiwan.
authors.forename: Chien-Jen
authors.initials: CJ
authors.lastname: Chen
authors.affiliation: Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Mei-Hsuan
authors.initials: MH
authors.lastname: Lee
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology*; D005260:Female; D016174:Hepacivirus; D018937:Hepatitis C Antibodies / Q000097:blood; D019698:Hepatitis C, Chronic / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012367:RNA, Viral / Q000097:blood; D012307:Risk Factors; D017678:Sex Distribution; D013624:Taiwan / Q000453:epidemiology
chemical_list: D018937:Hepatitis C Antibodies; D012367:RNA, Viral
keywords: 
  HCV RNA
  ; REVEAL-HCV cohort; extrahepatic disease