title: The evolving roles and controversies of radiotherapy in the treatment of glioblastoma.
abstract: Numerous randomised controlled trials have demonstrated the benefit of radiation therapy in patients with newly diagnosed glioblastoma and it has been the cornerstone of treatment for decades. The aims of this review are to (1) Briefly outline the historical studies which resulted in radiation being the current standard of care as used in the Stupp et al. trial (2) Discuss the evolving role of radiation therapy in the management of elderly patients (3) Review the current evidence and ongoing studies of radiation use in the recurrent/salvage setting and (4) Discuss the continuing controversies of volume delineation in the planning of radiation delivery.
authors.affiliation: Cure Brain Cancer Foundation Biomarkers and Translational Research Laboratory Prince of Wales Clinical School UNSW Sydney New South Wales Australia; Cancer Care Centre St George Hospital Sydney New South Wales Australia.
authors.forename: Eric
authors.initials: E
authors.lastname: Hau
authors.affiliation: Targeted Therapies Group Children's Cancer Institute Australia Lowy Cancer Research Centre Sydney New South Wales Australia.
authors.forename: Han
authors.initials: H
authors.lastname: Shen
authors.affiliation: Cancer Care Centre St George Hospital Sydney New South Wales Australia.
authors.forename: Catherine
authors.initials: C
authors.lastname: Clark
authors.affiliation: St George Cancer Care Centre Kogarah Sydney New South Wales Australia.
authors.forename: Peter H
authors.initials: PH
authors.lastname: Graham
authors.affiliation: Liverpool Cancer Care Centre Liverpool Hospital Sydney New South Wales Australia; University of New South Wales Sydney New South Wales Australia.
authors.forename: Eng-Siew
authors.initials: ES
authors.lastname: Koh
authors.affiliation: Cure Brain Cancer Foundation Biomarkers and Translational Research Laboratory Prince of Wales Clinical School UNSW Sydney New South Wales Australia.
authors.forename: Kerrie
authors.initials: K
authors.lastname: L McDonald
mesh_terms: D016543:Central Nervous System Neoplasms / Q000532:radiotherapy*; D005909:Glioblastoma / Q000532:radiotherapy*; D006801:Humans; D011878:Radiotherapy / Q000009:adverse effects / Q000379:methods*; D011879:Radiotherapy Dosage; D016032:Randomized Controlled Trials as Topic
keywords: Brain tumour; glioblastoma; radiation; radiotherapy