title: [Reduction in requirements of oral calcium and 1-25 dihydroxy vitamin D in patients with post-surgical hypoparathyroidism treated with teriparatide (PTH1-34)].
abstract: The objective of the study is to evaluate the effect of daily administration of recombinant parathyroid hormone (PTH1-34), 20 μg, on serum calcium concentrations (Cas), and the requirements of oral calcium and calcitriol in patients with hypoparathyroidism. It is a prospective, longitudinal study, analytical, with intervention, in patients treated with high doses of calcium (> 7 g/day), with symptoms of hypocalcemia and/or intolerant to treatment. Serum levels of phosphorus (Ps) and Cas, urinary calcium excretion, oral doses of calcitriol and calcium were compared before and after administration of teriparatide, for three months on average, in patients with post-surgical hypoparathyroidism. We studied 16 patients with oral elemental calcium requirements of 22.5 ± 16 g/day of calcitriol 0.79 ± 0.4 µg/day. Cas at baseline was 7.6 ± 1.2 and Ps 5.4 ± 0.76 mg/dl. After administration of teriparatide, Cas was 9.0 ± 0.69 mg/dl (p = 0.007) and Ps of 4.5 ± 0.87 mg/dl (p = 0.003). Doses of calcium and calcitriol showed a statistically significant reduction (p = 0.0001 and 0.001, respectively). We conclude that use of recombinant parathyroid hormone can normalize Cas and Ps, with reduction in oral calcium and calcitriol requirements.
authors.affiliation: Hospital Regional 1.º de octubre ISSSTE, Ciudad de México, México.
authors.forename: Leticia Eugenia
authors.initials: LE
authors.lastname: Gutiérrez-Cerecedo
authors.affiliation: CMN 20 de Noviembre ISSSTE, Ciudad de México, México.
authors.forename: Alma
authors.initials: A
authors.lastname: Vergara-López
authors.affiliation: Hospital Regional 1.º de octubre ISSSTE, Ciudad de México, México.
authors.forename: José Vicente
authors.initials: JV
authors.lastname: Rosas-Barrientos
authors.affiliation: CMN 20 de Noviembre ISSSTE, Ciudad de México, México.
authors.forename: Miguel Ángel
authors.initials: MÁ
authors.lastname: Guillén-González
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D002117:Calcitriol / Q000008:administration & dosage*; D002118:Calcium / Q000008:administration & dosage* / Q000097:blood; D005260:Female; D006801:Humans; D007011:Hypoparathyroidism / Q000188:drug therapy* / Q000209:etiology; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000008:administration & dosage*; D010758:Phosphorus / Q000097:blood; D011446:Prospective Studies; D011994:Recombinant Proteins / Q000008:administration & dosage; D019379:Teriparatide / Q000008:administration & dosage*
chemical_list: D010281:Parathyroid Hormone; D011994:Recombinant Proteins; D019379:Teriparatide; D010758:Phosphorus; D002117:Calcitriol; D002118:Calcium