title: Early and Intensive Dietary Counseling in Lung Cancer Patients Receiving (Chemo)Radiotherapy-A Pilot Randomized Controlled Trial.
abstract: Malnutrition is prevalent in patients undergoing (chemo)radiotherapy (RT) for lung cancer. This pilot study tested the feasibility and acceptability of delivering an intensive nutrition intervention for lung cancer patients receiving RT. Twenty-four patients with lung cancer were randomized to receive the intervention which employed a care pathway to guide intensive dietary counseling from pretreatment until 6-wk posttreatment or usual care. Nutritional, fatigue, and functional outcomes were assessed using valid and reliable questionnaires before randomization, at the start and end of RT and 1- and 3-mo post-RT. Consent rate was 57% with an overall attrition of 37%. Subject compliance with the completion of study questionnaires was 100%. A clinically important mean difference indicated greater overall satisfaction with nutritional care in the intervention group (5.00, interquartile range [IQR] 4.50-5.00; 4.00, IQR 4.00-4.00). Clinically important differences favoring the intervention were observed for weight (3.0 kg; 95% confidence interval [CI] -0.8, 6.8), fat-free mass (0.6 kg; 95% CI -2.1, 3.3), physical well-being (2.1; 95% CI -2.3, 6.5), and functional well-being (5.1; 95% CI 1.6, 8.6), but all 95% CIs were wide and most included zero. Recruitment feasibility and acceptability of the intervention were demonstrated, which suggest larger trials using an intensive nutrition intervention would be achievable.
authors.affiliation: a Department of Cancer Experiences Research , Peter MacCallum Cancer Centre , East Melbourne , Victoria , Australia.|b Faculty of Medicine , Dentistry and Health Sciences, School of Health Sciences, University of Melbourne , Melbourne , Victoria , Australia.|c Nutrition and Speech Pathology Department , Peter MacCallum Cancer Centre , East Melbourne , Victoria , Australia.
authors.forename: Nicole
authors.initials: N
authors.lastname: Kiss
authors.affiliation: d Faculty of Health Sciences and Medicine , Bond University , Robina , Queensland , Australia.|e Nutrition and Dietetics , Princess Alexandra Hospital , Brisbane , Queensland , Australia.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Isenring
authors.affiliation: a Department of Cancer Experiences Research , Peter MacCallum Cancer Centre , East Melbourne , Victoria , Australia.
authors.forename: Karla
authors.initials: K
authors.lastname: Gough
authors.affiliation: f Department of Radiation Oncology and Cancer Imaging , Peter MacCallum Cancer Centre , East Melbourne , Victoria , Australia.
authors.forename: Greg
authors.initials: G
authors.lastname: Wheeler
authors.affiliation: f Department of Radiation Oncology and Cancer Imaging , Peter MacCallum Cancer Centre , East Melbourne , Victoria , Australia.
authors.forename: Andrew
authors.initials: A
authors.lastname: Wirth
authors.affiliation: f Department of Radiation Oncology and Cancer Imaging , Peter MacCallum Cancer Centre , East Melbourne , Victoria , Australia.
authors.forename: Belinda A
authors.initials: BA
authors.lastname: Campbell
authors.affiliation: a Department of Cancer Experiences Research , Peter MacCallum Cancer Centre , East Melbourne , Victoria , Australia.|b Faculty of Medicine , Dentistry and Health Sciences, School of Health Sciences, University of Melbourne , Melbourne , Victoria , Australia.
authors.forename: Meinir
authors.initials: M
authors.lastname: Krishnasamy
mesh_terms: D000368:Aged; D002173:Cancer Care Facilities; D002289:Carcinoma, Non-Small-Cell Lung / Q000150:complications* / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D018288:Carcinoma, Small Cell / Q000150:complications* / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D003131:Combined Modality Therapy / Q000009:adverse effects; D004750:Enteral Nutrition; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D057194:Intention to Treat Analysis; D008175:Lung Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D008297:Male; D044342:Malnutrition / Q000150:complications / Q000453:epidemiology / Q000517:prevention & control* / Q000628:therapy; D008875:Middle Aged; D009367:Neoplasm Staging; D015596:Nutrition Assessment; D010342:Patient Acceptance of Health Care; D010352:Patient Dropouts; D010353:Patient Education as Topic; D010865:Pilot Projects; D057285:Precision Medicine; D012306:Risk; D014739:Victoria / Q000453:epidemiology