title: Platinum(iv) N-heterocyclic carbene complexes: their synthesis, characterisation and cytotoxic activity.
abstract: Platinum(ii) N-heterocyclic carbene complexes have been oxidized by bromine or iodobenzene dichloride to provide the fully characterised corresponding platinum(iv) NHC complexes. Antiproliferative activities of Pt(iv) NHC complexes were assayed against several cancer cell lines and the results were correlated with respect to their stability. Mechanistic investigations revealed that mitochondrial dysfunction and ROS production were associated with the cytotoxic process induced by these compounds.
authors.affiliation: Institut de Physique et Chimie des Matériaux de Strasbourg, Université de Strasbourg-CNRS UMR7504, 23 rue du Loess, BP 43, 67034 Strasbourg Cedex 2, France. bellemin@unistra.fr.
authors.forename: M
authors.initials: M
authors.lastname: Bouché
authors.forename: G
authors.initials: G
authors.lastname: Dahm
authors.forename: M
authors.initials: M
authors.lastname: Wantz
authors.forename: S
authors.initials: S
authors.lastname: Fournel
authors.forename: T
authors.initials: T
authors.lastname: Achard
authors.forename: S
authors.initials: S
authors.lastname: Bellemin-Laponnaz
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D008928:Mitochondria / Q000187:drug effects; D017671:Platinum Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D006571:Heterocyclic Compounds; D017671:Platinum Compounds; C030011:carbene; D008697:Methane