title: Usefulness of spleen volume measured by computed tomography for predicting clinical outcome in primary myelofibrosis.
abstract: Although splenomegaly is major characteristic of primary myelofibrosis (PMF), splenomegaly has been devalued due to a less reliable method based on physical examination (PEx). We evaluated whether spleen volume (SV) on CT would accurately predict clinical outcomes in PMF. A total of 188 patients were enrolled. SV was quantitated by the automatic volume software. In ROC curve, the SV predicted prognosis more accurately than spleen length by PEx (p < 0.001). The ideal cut-off value was 378.1 cm(3) for SV, which was divided into high- and low-volume status. Patients with low SV status had superior leukemia-free survival and overall survival compared to high SV status (p < 0.001, p < 0.001) In the Cox analysis, old age ≥65 years (p = 0.004, p = 0.001), low Hemoglobin <10.0 g/dL (p = 0.023, p = 0.021), high WBC counts ≥25 × 10(9)/L (p = 0.003, p = 0.006), peripheral blasts ≥1 % (p = 0.029, p = 0.020), unfavorable cytogenetic abnormalities (p = 0.025, p = 0.028), and high SV status (p = 0.004, p = 0.003) were independently associated with survivals. SV measured by CT was important for predicting survival in patients with PMF.
authors.affiliation: Department of Hematology-Oncology, Hanyang University Hanmaeum Changwon Hospital, WoniDae-Ro 682 road, 21 Changwon, 51497, Republic of Korea. song9676@hanmail.net.
authors.forename: Moo-Kon
authors.initials: MK
authors.lastname: Song
authors.affiliation: Department of Hematology-Oncology, Pusan National University Hospital, Busan, Korea.
authors.forename: Joo-Seop
authors.initials: JS
authors.lastname: Chung
authors.affiliation: Department of Hematology, Haeundae Paik Hospital, Busan, Korea.
authors.forename: Sung-Nam
authors.initials: SN
authors.lastname: Lim
authors.affiliation: Department of Hematology, Gyeong-Sang National University Hospital, School of Medicine, Gyeong-Sang National University, Jinju, Korea.
authors.forename: Gyeong-Won
authors.initials: GW
authors.lastname: Lee
authors.affiliation: Department of Hematology, Busan Paik Hospital, Busan, Korea.
authors.forename: Sang-Min
authors.initials: SM
authors.lastname: Lee
authors.affiliation: Department of Radiology, Pusan National University Hospital, Busan, Korea.
authors.forename: Nam-Kyung
authors.initials: NK
authors.lastname: Lee
authors.affiliation: Department of Laboratory Medicine, Hanyang University Hanmaeum Changwon Hospital, Changwon, Korea.
authors.forename: Jae-Cheol
authors.initials: JC
authors.lastname: Choi
authors.affiliation: Department of Hematology-Oncology, Pusan National University Yangsan Hospital, Yangsan, Korea.
authors.forename: So-Yeon
authors.initials: SY
authors.lastname: Oh
mesh_terms: D000368:Aged; D006801:Humans; D008875:Middle Aged; D009929:Organ Size; D055728:Primary Myelofibrosis / Q000175:diagnosis* / Q000401:mortality; D011379:Prognosis; D012984:Software; D013154:Spleen / Q000473:pathology*; D015996:Survival Rate; D014057:Tomography, X-Ray Computed / Q000379:methods* / Q000592:standards
keywords: Computed tomography; Overall survival; Primary myelofibrosis; Splenic volume; Splenomegaly