title: Effects of a Multicomponent Life-Style Intervention on Weight, Glycemic Control, Depressive Symptoms, and Renal Function in Low-Income, Minority Patients With Type 2 Diabetes: Results of the Community Approach to Lifestyle Modification for Diabetes Randomized Controlled Trial.
abstract: Few interventions have combined life-style and psychosocial approaches in the context of Type 2 diabetes management. The purpose of this study was to determine the effect of a multicomponent behavioral intervention on weight, glycemic control, renal function, and depressive symptoms in a sample of overweight/obese adults with Type 2 diabetes and marked depressive symptoms.
  
  
  
  A sample of 111 adults with Type 2 diabetes were randomly assigned to a 1-year intervention (n = 57) or usual care (n = 54) in a parallel groups design. Primary outcomes included weight, glycosylated hemoglobin, and Beck Depression Inventory II score. Estimated glomerular filtration rate served as a secondary outcome. All measures were assessed at baseline and 6 and 12 months after randomization by assessors blind to randomization. Latent growth modeling was used to examine intervention effects on each outcome.
  
  
  
  The intervention resulted in decreased weight (mean [M] = 0.322 kg, standard error [SE] = 0.124 kg, p = .010) and glycosylated hemoglobin (M = 0.066%, SE = 0.028%, p = .017), and Beck Depression Inventory II scores (M = 1.009, SE = 0.226, p < .001), and improved estimated glomerular filtration rate (M = 0.742 ml·min·1.73 m, SE = 0.318 ml·min·1.73 m, p = .020) each month during the first 6 months relative to usual care.
  
  
  
  Multicomponent behavioral interventions targeting weight loss and depressive symptoms as well as diet and physical activity are efficacious in the management of Type 2 diabetes.
  
  
  
  This study is registered at Clinicaltrials.gov ID: NCT01739205.
authors.affiliation: From the Department of Psychology (Moncrieft, Llabre, McCalla, Gellman, Schneiderman), University of Miami, Coral Gables, Florida; and Behavioral Medicine Research Center (Moncrieft, Llabre, McCalla, Gutt, Mendez, Gellman, Goldberg, Schneiderman) and Diabetes Research Institute, Department of Medicine, Division of Endocrinology, Diabetes and Metabolism (Mendez, Goldberg), Miller School of Medicine, University of Miami, Miami, Florida.
authors.forename: Ashley E
authors.initials: AE
authors.lastname: Moncrieft
authors.forename: Maria M
authors.initials: MM
authors.lastname: Llabre
authors.forename: Judith Rey
authors.initials: JR
authors.lastname: McCalla
authors.forename: Miriam
authors.initials: M
authors.lastname: Gutt
authors.forename: Armando J
authors.initials: AJ
authors.lastname: Mendez
authors.forename: Marc D
authors.initials: MD
authors.lastname: Gellman
authors.forename: Ronald B
authors.initials: RB
authors.lastname: Goldberg
authors.forename: Neil
authors.initials: N
authors.lastname: Schneiderman
mesh_terms: D000328:Adult; D000368:Aged; D001521:Behavior Therapy / Q000379:methods*; D003131:Combined Modality Therapy; D003863:Depression / Q000628:therapy*; D003924:Diabetes Mellitus, Type 2 / Q000628:therapy*; D004035:Diet Therapy / Q000379:methods*; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000628:therapy; D017063:Outcome Assessment, Health Care; D050177:Overweight / Q000628:therapy*; D040242:Risk Reduction Behavior; D000067570:Social Learning; D015431:Weight Loss / Q000502:physiology
chemical_list: D006442:Glycated Hemoglobin