title: A Variant in ADIPOR2 Is Associated with Increased Free Fatty Acid Levels in Chinese Population.
abstract: Elevated free fatty acids (FFAs) are thought to play an important role in the development of insulin resistance. Adiponectin is an adipose tissue-secreted protein known for its effects on the stimulation of fatty acid oxidation. The aim of this study was to investigate the association of adiponectin receptor 2 gene variations with FFAs levels in subjects with normal fasting glucose levels in Chinese Han population.
  
  
  
  Four common single nucleotide polymorphisms of ADIPOR2 were genotyped using the TaqMan method to perform association studies with metabolic parameters in 1819 subjects among Chinese Han population. All the subjects were divided into two groups: normal FFAs group (FFAs ≤0.88 mmol/L) and high FFAs group (FFAs >0.88 mmol/L).
  
  
  
  There was a significant association of rs2370055 with higher FFA levels in major T-allele carriers (P = 0.000). There was a significant difference in the distribution of genotypes of polymorphism rs2370055 between normal and high FFA groups. The frequencies of TT and CT genotypes are significantly higher in subjects with high FFA level than those in the normal FFAs group (P = 0.013 and P = 0.004, respectively). After adjustment for age, sex, body mass index, triglyceride, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoproteincholesterol, the TT and CT genotypes are both independent risk factors for high FFAs level.
  
  
  
  Our findings suggest that variants of ADIPOR2 could be a determinant for higher FFA levels, and among Chinese Han population, carriers of the CT and TT genotypes for rs2370055 even with normal glucose levels may have significantly higher insulin resistance susceptibility.
authors.affiliation: 1 Department of Clinical Laboratory Medicine, Beijing Shijitan Hospital, Peking University Ninth School of Clinical Medicine , Beijing, China .|2 Beijing Shijitan Hospital, Capital Medical University , Beijing, China .
authors.forename: Guihua
authors.initials: G
authors.lastname: Yang
authors.affiliation: 1 Department of Clinical Laboratory Medicine, Beijing Shijitan Hospital, Peking University Ninth School of Clinical Medicine , Beijing, China .|2 Beijing Shijitan Hospital, Capital Medical University , Beijing, China .
authors.forename: Na
authors.initials: N
authors.lastname: Liu
authors.affiliation: 1 Department of Clinical Laboratory Medicine, Beijing Shijitan Hospital, Peking University Ninth School of Clinical Medicine , Beijing, China .|2 Beijing Shijitan Hospital, Capital Medical University , Beijing, China .
authors.forename: Mei
authors.initials: M
authors.lastname: Hu
authors.affiliation: 1 Department of Clinical Laboratory Medicine, Beijing Shijitan Hospital, Peking University Ninth School of Clinical Medicine , Beijing, China .|2 Beijing Shijitan Hospital, Capital Medical University , Beijing, China .
authors.forename: Xuli
authors.initials: X
authors.lastname: Xin
authors.affiliation: 1 Department of Clinical Laboratory Medicine, Beijing Shijitan Hospital, Peking University Ninth School of Clinical Medicine , Beijing, China .|2 Beijing Shijitan Hospital, Capital Medical University , Beijing, China .
authors.forename: Jing
authors.initials: J
authors.lastname: Han
authors.affiliation: 1 Department of Clinical Laboratory Medicine, Beijing Shijitan Hospital, Peking University Ninth School of Clinical Medicine , Beijing, China .|2 Beijing Shijitan Hospital, Capital Medical University , Beijing, China .
authors.forename: Yuyu
authors.initials: Y
authors.lastname: Cai
authors.affiliation: 1 Department of Clinical Laboratory Medicine, Beijing Shijitan Hospital, Peking University Ninth School of Clinical Medicine , Beijing, China .|2 Beijing Shijitan Hospital, Capital Medical University , Beijing, China .
authors.forename: Zhiying
authors.initials: Z
authors.lastname: Hu
authors.affiliation: 1 Department of Clinical Laboratory Medicine, Beijing Shijitan Hospital, Peking University Ninth School of Clinical Medicine , Beijing, China .|2 Beijing Shijitan Hospital, Capital Medical University , Beijing, China .
authors.forename: Chundi
authors.initials: C
authors.lastname: Jia
authors.affiliation: 1 Department of Clinical Laboratory Medicine, Beijing Shijitan Hospital, Peking University Ninth School of Clinical Medicine , Beijing, China .|2 Beijing Shijitan Hospital, Capital Medical University , Beijing, China .
authors.forename: Man
authors.initials: M
authors.lastname: Zhang
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics* / Q000706:statistics & numerical data; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics; D050356:Lipid Metabolism / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D054419:Receptors, Adiponectin / Q000235:genetics*
chemical_list: C475420:ADIPOR2 protein, human; D005230:Fatty Acids, Nonesterified; D054419:Receptors, Adiponectin