title: F10 cytotoxicity via topoisomerase I cleavage complex repair consistent with a unique mechanism for thymineless death.
authors.affiliation: Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
authors.forename: William H
authors.initials: WH
authors.lastname: Gmeiner
authors.affiliation: Laboratory of Molecular Biology & Immunology, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
authors.forename: Patricia J
authors.initials: PJ
authors.lastname: Gearhart
authors.affiliation: Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-4255, USA.
authors.forename: Yves
authors.initials: Y
authors.lastname: Pommier
authors.affiliation: University of North Carolina, Chapel Hill, NC 27599, USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Nakamura
mesh_terms: D016923:Cell Death / Q000187:drug effects* / Q000235:genetics*; D053904:DNA Breaks, Single-Stranded; D004260:DNA Repair; D004264:DNA Topoisomerases, Type I / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D055785:Gene Knockdown Techniques; D006801:Humans; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism*; D011108:Polymers; D011743:Pyrimidines / Q000737:chemistry / Q000633:toxicity*; D013941:Thymine / Q000378:metabolism*
chemical_list: D011108:Polymers; D011743:Pyrimidines; D010727:Phosphoric Diester Hydrolases; C498508:TDP1 protein, human; D004264:DNA Topoisomerases, Type I; D013941:Thymine
keywords: DNA repair; DNA topoisomerase I; F10; thymineless death