title: Effect of aerobic exercise on physical performance in patients with Alzheimer's disease.
abstract: Knowledge about the feasibility and effects of exercise programs to persons with Alzheimer's disease is lacking. This study investigated the effect of aerobic exercise on physical performance in community-dwelling persons with mild Alzheimer's disease.
  
  
  
  The single blinded multi-center RCT (ADEX) included 200 patients, median age 71 yrs (50-89). The intervention group received supervised moderate-to-high intensity aerobic exercise 1 hour × 3/week for 16 weeks. Assessments included cardiorespiratory fitness, single-task physical performance, dual-task performance and exercise self-efficacy.
  
  
  
  Significant between-group differences in change from baseline (mean [95%CI]) favored the intervention group for cardiorespiratory fitness (4.0 [2.3-5.8] ml/kg/min, P <0.0001) and exercise self-efficacy (1.7 [0.5-2.8] points, P =0.004). Furthermore, an exercise attendance of ≥66.6% resulted in significant positive effects on single-task physical performance and dual-task performance.
  
  
  
  Aerobic exercise has the potential to improve cardiorespiratory fitness, single-task physical performance, dual-task performance and exercise self-efficacy in community-dwelling patients with mild Alzheimer's disease.
authors.affiliation: Musculoskeletal Rehabilitation Research Unit and Institute of Sports Medicine, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Nanna Aue
authors.initials: NA
authors.lastname: Sobol
authors.affiliation: Danish Dementia Research Center, Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
authors.forename: Kristine
authors.initials: K
authors.lastname: Hoffmann
authors.affiliation: Danish Dementia Research Center, Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
authors.forename: Kristian Steen
authors.initials: KS
authors.lastname: Frederiksen
authors.affiliation: Danish Dementia Research Center, Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Department of Psychology, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Asmus
authors.initials: A
authors.lastname: Vogel
authors.affiliation: Dementia Clinic, Aalborg University Hospital, Aalborg, Denmark.
authors.forename: Karsten
authors.initials: K
authors.lastname: Vestergaard
authors.affiliation: Dementia Clinic, Aarhus University Hospital, Aarhus N, Denmark.
authors.forename: Hans
authors.initials: H
authors.lastname: Brændgaard
authors.affiliation: Dementia Clinic, Aarhus University Hospital, Aarhus N, Denmark.
authors.forename: Hanne
authors.initials: H
authors.lastname: Gottrup
authors.affiliation: Dementia Clinic, Odense University Hospital, Odense, Denmark.
authors.forename: Annette
authors.initials: A
authors.lastname: Lolk
authors.affiliation: Dementia Clinic, Odense University Hospital, Odense, Denmark.
authors.forename: Lene
authors.initials: L
authors.lastname: Wermuth
authors.affiliation: Department of Geriatrics, Odense University Hospital, Svendborg Hospital, Svendborg, Denmark.
authors.forename: Søren
authors.initials: S
authors.lastname: Jakobsen
authors.affiliation: Department of Geriatrics, Slagelse Hospital, Slagelse, Denmark.
authors.forename: Lars
authors.initials: L
authors.lastname: Laugesen
authors.affiliation: Department of Geriatrics, Slagelse Hospital, Slagelse, Denmark.
authors.forename: Robert
authors.initials: R
authors.lastname: Gergelyffy
authors.affiliation: Zeland University Hospital, Department of Neurology, Regional Dementia Research Centre, Roskilde, Denmark.
authors.forename: Peter
authors.initials: P
authors.lastname: Høgh
authors.affiliation: Memory Clinic, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark.
authors.forename: Eva
authors.initials: E
authors.lastname: Bjerregaard
authors.affiliation: Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Volkert
authors.initials: V
authors.lastname: Siersma
authors.affiliation: Danish Dementia Research Center, Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
authors.forename: Birgitte Bo
authors.initials: BB
authors.lastname: Andersen
authors.affiliation: Danish Dementia Research Center, Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
authors.forename: Peter
authors.initials: P
authors.lastname: Johannsen
authors.affiliation: Danish Dementia Research Center, Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
authors.forename: Gunhild
authors.initials: G
authors.lastname: Waldemar
authors.affiliation: Danish Dementia Research Center, Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
authors.forename: Steen Gregers
authors.initials: SG
authors.lastname: Hasselbalch
authors.affiliation: Musculoskeletal Rehabilitation Research Unit and Institute of Sports Medicine, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark. Electronic address: ninabeyer.privat@gmail.com.
authors.forename: Nina
authors.initials: N
authors.lastname: Beyer
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000628:therapy*; D000072599:Cardiorespiratory Fitness / Q000502:physiology*; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D057187:Independent Living; D008297:Male; D011788:Quality of Life
keywords: Aerobic exercise; Alzheimer's disease; Cardiorespiratory fitness; Community-dwelling; Dual-task performance; Self-efficacy; Single-task physical performance