title: Efficacy of midazolam as oral premedication in children in comparison to triclofos sodium.
abstract: OBJECTIVE
  The perioperative behavioural studies demonstrate that children are at greater risk of experiencing turbulent anaesthetic induction and adverse behavioural sequelae. We aimed to compare the efficacy of midazolam 0.5 mg/kg with triclofos sodium 100 mg/kg as oral premedication in children undergoing elective surgery.
  
  
  METHODS
  In this prospective, randomised and double-blind study, sixty children posted for elective lower abdominal surgery were enrolled. The patients were randomly divided into midazolam group (Group M) and triclofos sodium group (Group T) of thirty each. Group M received oral midazolam 0.5 mg/kg 30 min before induction, and Group T received oral triclofos sodium 100 mg/kg 60 min before induction. All children were evaluated for level of sedation after premedication, behaviour at the time of separation from parents and at the time of mask placement for induction of anaesthesia. Mann-Whitney U-test was used for comparing the grade of sedation, ease of separation and acceptance of face mask.
  
  
  RESULTS
  Oral midazolam produced adequate sedation in children after premedication in comparison to oral triclofos (P = 0.002). Both drugs produced successful separation from parents, and the children were very cooperative during induction. No adverse effects attributable to the premedicants were seen.
  
  
  CONCLUSIONS
  Oral midazolam is superior to triclofos sodium as a sedative anxiolytic in paediatric population.
authors.affiliation: Department of Anaesthesiology, Government Medical College, Kozhikode, Kerala, India.
authors.forename: Kolathu Parambil
authors.initials: KP
authors.lastname: Radhika
authors.affiliation: Department of Anaesthesiology, MES Medical College and Hospital, Malappuram, Kerala, India.
authors.forename: Melveetil S
authors.initials: MS
authors.lastname: Sreejit
authors.affiliation: Department of Anaesthesiology, Government Medical College, Kozhikode, Kerala, India.
authors.forename: Konnanath T
authors.initials: KT
authors.lastname: Ramadas
keywords: Anaesthesia; hypnotics and sedatives; midazolam; paediatrics; premedication; triclofos