title: Hierarchical polymer coating for optimizing the antifouling and bactericidal efficacies.
abstract: The bacteria-repellent and bactericidal functionalities in a single system are generally need to be carefully optimized in order to obtain the highest antibacterial performance. In this study, the controlled SI-PIMP strategy was developed for creating hierarchical polymer brushes possessing the bacteria-repellent and bactericidal functionalities. To obtain a bactericidal surface with minimal interference to its nonfouling property, optimization studies were conducted by facilely tailoring the surface density of the quaternary ammonium compound moieties through control over the monomer concentration. An optimal hierarchical polymer coating showed potent protein and bacteria repellence as well as certain bactericidal property. The longlasting antibacterial performance was also achieved due to the good balance between the dual functionalities. The tenability of the hierarchical polymer coating is applicable to surface chemistries for biosensors, molecular imaging, and biomedical applications.
authors.affiliation: a State Key Laboratory of Polymer Physics and Chemistry , Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun , People's Republic of China.|b University of Chinese Academy of Sciences , Beijing , People's Republic of China.
authors.forename: Shunjie
authors.initials: S
authors.lastname: Yan
authors.affiliation: a State Key Laboratory of Polymer Physics and Chemistry , Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun , People's Republic of China.
authors.forename: Lingjie
authors.initials: L
authors.lastname: Song
authors.affiliation: c The Thoracic Department of The First Hospital of Jilin University , Changchun , People's Republic of China.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Li
authors.affiliation: a State Key Laboratory of Polymer Physics and Chemistry , Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun , People's Republic of China.
authors.forename: Shifang
authors.initials: S
authors.lastname: Luan
authors.affiliation: a State Key Laboratory of Polymer Physics and Chemistry , Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun , People's Republic of China.
authors.forename: Hengchong
authors.initials: H
authors.lastname: Shi
authors.affiliation: d School of Chemistry and Chemical Engineering , Yantai University , Yantai , People's Republic of China.
authors.forename: Zhirong
authors.initials: Z
authors.lastname: Xin
authors.affiliation: a State Key Laboratory of Polymer Physics and Chemistry , Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun , People's Republic of China.
authors.forename: Shenghai
authors.initials: S
authors.lastname: Li
authors.affiliation: a State Key Laboratory of Polymer Physics and Chemistry , Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun , People's Republic of China.
authors.forename: Yuming
authors.initials: Y
authors.lastname: Yang
authors.affiliation: a State Key Laboratory of Polymer Physics and Chemistry , Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun , People's Republic of China.
authors.forename: Jinghua
authors.initials: J
authors.lastname: Yin
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001422:Bacterial Adhesion; D048271:Chitosan / Q000031:analogs & derivatives* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects* / Q000502:physiology*; D008027:Light; D008689:Methacrylates / Q000138:chemical synthesis / Q000737:chemistry; D058105:Polymerization; D000644:Quaternary Ammonium Compounds / Q000737:chemistry; D012825:Silicon; D013499:Surface Properties
chemical_list: D000900:Anti-Bacterial Agents; D008689:Methacrylates; D000644:Quaternary Ammonium Compounds; C495830:chitosan-N-2-hydroxypropyl trimethyl ammonium chloride; C521589:sulfobetaine methacrylate polymer; D048271:Chitosan; D012825:Silicon
keywords: Surface-initiated photoiniferter-mediated polymerization; bacteria-repellent; bacterial surface accumulation; bactericidal; hierarchical polymer brush