title: Concise Review: Fate Determination of Stem Cells by Deubiquitinating Enzymes.
abstract: Post-translational modification by ubiquitin molecules is a key regulatory process for stem cell fate determination. Ubiquitination and deubiquitination are the major cellular processes used to balance the protein turnover of several transcription factors that regulate stem cell differentiation. Deubiquitinating enzymes (DUBs), which facilitate the processing of ubiquitin, significantly influence stem cell fate choices. Specifically, DUBs play a critical regulatory role during development by directing the production of new specialized cells. This review focuses on the regulatory role of DUBs in various cellular processes, including stem cell pluripotency and differentiation, adult stem cell signaling, cellular reprogramming, spermatogenesis, and oogenesis. Specifically, the identification of interactions of DUBs with core transcription factors has provided new insight into the role of DUBs in regulating stem cell fate determination. Thus, DUBs have emerged as key pharmacologic targets in the search to develop highly specific agents to treat various illnesses. Stem Cells 2017;35:9-16.
authors.affiliation: Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul, Korea.
authors.forename: Arun Pandian
authors.initials: AP
authors.lastname: Chandrasekaran
authors.affiliation: Department of Pharmacology and Brain Korea 21 plus Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: Bharathi
authors.initials: B
authors.lastname: Suresh
authors.affiliation: Department of Pharmacology and Brain Korea 21 plus Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: Hyongbum Henry
authors.initials: HH
authors.lastname: Kim
authors.affiliation: Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul, Korea.|College of Medicine, Hanyang University, Seoul, South Korea.
authors.forename: Kye-Seong
authors.initials: KS
authors.lastname: Kim
authors.affiliation: Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul, Korea.|College of Medicine, Hanyang University, Seoul, South Korea.
authors.forename: Suresh
authors.initials: S
authors.lastname: Ramakrishna
mesh_terms: D000818:Animals; D019070:Cell Lineage; D065150:Cellular Reprogramming; D000072017:Deubiquitinating Enzymes / Q000378:metabolism*; D006801:Humans; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism; D025801:Ubiquitin / Q000378:metabolism
chemical_list: D025801:Ubiquitin; D000072017:Deubiquitinating Enzymes; D046988:Proteasome Endopeptidase Complex
keywords: Deubiquitinating enzymes; Deubiquitination; Differentiation; Oogenesis; Pluripotency; Post-translational modification; Spermatogenesis; Ubiquitination