title: A Practical Approach to the Diagnosis and Treatment of Vitiligo in Children.
abstract: Vitiligo is a common inflammatory skin disease with a worldwide prevalence of 0.5% to 2.0% of the population. In the pediatric population, the exact prevalence of vitiligo is unknown, although many studies state that most cases of vitiligo are acquired early in life. The disease is disfiguring, with a major psychological impact on children and their parents. Half of vitiligo cases have a childhood onset, needing thus a treatment approach that will minimize treatment side effects while avoiding psychological impacts. Management of vitiligo should take into account several factors, including extension, psychological impact, and possible associations with other autoimmune diseases. This review discusses the epidemiology of vitiligo and outlines the various clinical presentations associated with the disorder and their differential diagnosis. In addition, the pathophysiology and genetic determinants, the psychological impact of vitiligo, and management strategies are reviewed.
authors.affiliation: Department of Dermatology, Henri Mondor Hospital and EpiDermE, Université Paris-Est Créteil Val-de-Marne, Créteil, France; and khaled.ezzedine@aphp.fr.
authors.forename: Khaled
authors.initials: K
authors.lastname: Ezzedine
authors.affiliation: Department of Dermatology and Pediatrics, Mount Sinai St. Luke's-Roosevelt and Beth Israel Medical Centers, New York, New York.
authors.forename: Nanette
authors.initials: N
authors.lastname: Silverberg
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002648:Child; D003131:Combined Modality Therapy; D003879:Dermatologic Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D019587:Dietary Supplements; D020022:Genetic Predisposition to Disease; D014943:Global Health; D006801:Humans; D010789:Phototherapy; D011613:Psychotherapy; D016038:Skin Transplantation; D014820:Vitiligo / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology / Q000628:therapy*
chemical_list: D000893:Anti-Inflammatory Agents; D003879:Dermatologic Agents