title: Incorporating human leukocyte antibody results into clinical practice.
abstract: The use of human leukocyte antigen (HLA) antibody testing by solid-phase assay has improved both the specificity and sensitivity of HLA antibody detection. It did, however, introduce questions regarding interpretation of crossmatch results in light of these additional data. Herein we provide a clinician's and a laboratory professional's perspective on incorporating HLA results into clinical practice. We strongly encourage fostering ongoing dialog between the two disciplines to develop appropriate, specific guidelines.
authors.affiliation: Transplant Immunology Laboratory, Comprehensive Transplant Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. Electronic address: a-tambur@northwestern.edu.
authors.forename: Anat R
authors.initials: AR
authors.lastname: Tambur
authors.affiliation: Heart Transplantation Unit, Department of Cardiac Surgery, Leviev Heart Center, Sheba Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Jacob
authors.initials: J
authors.lastname: Lavee
mesh_terms: D000906:Antibodies; D006680:HLA Antigens; D006650:Histocompatibility Testing; D006801:Humans; D007518:Isoantibodies; D007962:Leukocytes; D012680:Sensitivity and Specificity
chemical_list: D000906:Antibodies; D006680:HLA Antigens; D007518:Isoantibodies
keywords: HLA antibodies; donor specific antibodies; heart transplantation; solid-phase assays; virtual crossmatch