title: Impact of a Eukaryotic Translation Initiation Factor 3a Polymorphism on Susceptibility to Gastric Cancer.
abstract: OBJECTIVE
  To investigate single nucleotide polymorphisms in the eukaryotic translation initiation factor 3a (eIF3a) gene and the risk for gastric cancer within the Chinese population.
  
  
  METHODS
  A total of 322 patients with gastric cancer were selected as the patient group and 340 non-gastric cancer patients were selected as the control group using the case-control method. Polymerase chain reaction-sequence-specific primer technology was leveraged to genotype the rs77382849 single nucleotide polymorphism in the eIF3a gene. The demographic characteristics of the study population and other exposures to risk factors were collected. Unconditional logistic regression analysis was performed to determine the association between the risk factors and gastric cancer.
  
  
  RESULTS
  A higher frequency of the eIF3a rs77382849 GG homozygote genotype was observed in the gastric cancer patients compared with the controls (63.98 vs. 54.41%, p < 0.05). After adjustment of exposure risks, such as age, gender, smoking, and drinking, the rs77382849 single nucleotide polymorphism was still associated with susceptibility to gastric cancer. When the eIF3a rs77382849 GG homozygote genotype was used as the reference group, the GA genotype (GA vs. GG: OR = 0.545, 95% CI: 0.386-0.769, p = 0.001) and AA genotype (AA vs. GG: OR = 0.245, 95% CI: 0.072-0.836, p = 0.025) were both correlated with a significantly decreased risk for gastric cancer development.
  
  
  CONCLUSIONS
  An association between eIF3a rs77382849 polymorphism and susceptibility to gastric cancer was observed in these Chinese patients.
authors.affiliation: Department of General Surgery, The Second Xiangya Hospital, Central South University, Changsha, PR China.
authors.forename: Kuijie
authors.initials: K
authors.lastname: Liu
authors.forename: Zhendong
authors.initials: Z
authors.lastname: Lei
authors.forename: Hongliang
authors.initials: H
authors.lastname: Yao
authors.forename: Sanlin
authors.initials: S
authors.lastname: Lei
authors.forename: Hua
authors.initials: H
authors.lastname: Zhao
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D016022:Case-Control Studies; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015438:Health Behavior; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D039665:Prokaryotic Initiation Factor-3 / Q000235:genetics*; D012307:Risk Factors; D012959:Socioeconomic Factors; D013274:Stomach Neoplasms / Q000235:genetics*
chemical_list: D039665:Prokaryotic Initiation Factor-3