title: Outcomes After Oncoplastic Breast-Conserving Surgery in Breast Cancer Patients: A Systematic Literature Review.
abstract: Surgeons have increasingly performed breast-conserving surgery (BCS) utilizing oncoplastic techniques in place of standard lumpectomy for early-stage breast cancer. We assess oncologic outcomes after oncoplastic BCS for T1-T2 breast cancer.
  
  
  
  A systematic literature review identified peer-reviewed articles in PubMed evaluating BCS with oncoplastic reconstruction. Selected studies reported on positive margin rate (PMR), re-excision rate (RR), conversion to mastectomy rate (CMR), overall survival (OS), disease-free survival (DFS), local recurrence (LR), distant recurrence (DR), complication rate, and/or cosmetic outcomes.
  
  
  
  The search yielded 474 articles; 55 met the inclusion criteria and collectively evaluated 6011 patients with a mean age 54.6 years over a mean follow-up 50.5 months. T1 (43.8 %) and T2 (39.3 %) invasive ductal carcinoma were the most common tumor histopathologies. PMR, RR, and CMR were 10.8, 6.0, and 6.2 %, respectively, while OS, DFS, LR and DR were 95.0, 90.0, 3.2, and 8.7 %, respectively. Margin widths were heterogeneously defined in studies that included margin assessment. The PMR was not significantly different when positive margins were defined as tumor <10, <5, < 2, and <1 mm from ink margin, or tumor on ink (p = 0.162). Eleven studies reported specific margins for 1455 patients, of whom 143 (9.8 %) had positive margins, including 113 (7.8 %) with tumor on ink.
  
  
  
  This study is the largest comprehensive literature review to date on oncoplastic BCS. Our systematic review reveals high rates of OS and DFS with low LR, DR, PMR, RR, CMR and complication rates, thereby confirming the oncologic safety of this procedure in patients with T1-T2 invasive breast cancer.
authors.affiliation: Rena Rowan Breast Center, Abramson Cancer Center, and the Department of Endocrine and Oncologic Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. lcruzclaver@gmail.com.|, Palm Beach, FL, USA. lcruzclaver@gmail.com.
authors.forename: Lucy
authors.initials: L
authors.lastname: De La Cruz
authors.affiliation: Department of Medical Education, University of Miami Miller School of Medicine, Miami, FL, USA.
authors.forename: Stephanie A
authors.initials: SA
authors.lastname: Blankenship
authors.affiliation: Department of Surgery, Tufts University Medical Center, Boston, MA, USA.
authors.forename: Abhishek
authors.initials: A
authors.lastname: Chatterjee
authors.affiliation: Rena Rowan Breast Center, Abramson Cancer Center, and the Department of Endocrine and Oncologic Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Rula
authors.initials: R
authors.lastname: Geha
authors.affiliation: Rena Rowan Breast Center, Abramson Cancer Center, and the Department of Endocrine and Oncologic Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Nadia
authors.initials: N
authors.lastname: Nocera
authors.affiliation: Rena Rowan Breast Center, Abramson Cancer Center, and the Department of Endocrine and Oncologic Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Czerniecki
authors.affiliation: Rena Rowan Breast Center, Abramson Cancer Center, and the Department of Endocrine and Oncologic Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Julia
authors.initials: J
authors.lastname: Tchou
authors.affiliation: Rena Rowan Breast Center, Abramson Cancer Center, and the Department of Endocrine and Oncologic Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Carla S
authors.initials: CS
authors.lastname: Fisher
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery*; D018572:Disease-Free Survival; D004954:Esthetics; D005260:Female; D006801:Humans; D016462:Mammaplasty / Q000009:adverse effects; D015412:Mastectomy, Segmental / Q000009:adverse effects / Q000379:methods*; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D018365:Neoplasm, Residual; D012086:Reoperation; D015996:Survival Rate