title: In vitro and in vivo chemo-phototherapy of magnetic TiO2 drug delivery system formed by pH-sensitive coordination bond.
abstract: To achieve tumor-specific delivery of doxorubicin, TiO2@Fe3O4/PEI/delivery of doxorubicin conjugates were designed and synthesized. Fe3O4could act as magnetically responsive carriers and enhance the visible light photodynamic activities of TiO2Delivery of doxorubicin was conjugated via coordination bond. The drug release rate at pH 5.2 was much faster than that at pH 7.4, due to pH-sensitive coordination bond. Besides, TiO2@Fe3O4/PEI/delivery of doxorubicin showed high antitumor efficacy combining with phototherapy, good bio-safety, higher cellular uptake with an external magnetic field, and less toxicity in vitro and in vivo. These results suggested that TiO2@Fe3O4/PEI/delivery of doxorubicin may be promising for high tumor treatment efficacy with minimal side effects in future.
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou, China.
authors.forename: Huijuan
authors.initials: H
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.
authors.forename: Yandan
authors.initials: Y
authors.lastname: Ji
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Chen
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Zhu
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.
authors.forename: Xiaoge
authors.initials: X
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Tan
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Tian
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.
authors.forename: Xiangbo
authors.initials: X
authors.lastname: Yang
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou, China zhangzz08@126.com.
authors.forename: Zhenzhong
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D003692:Delayed-Action Preparations / Q000008:administration & dosage* / Q000737:chemistry; D004058:Diffusion; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D058185:Magnetite Nanoparticles / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure; D051379:Mice; D008807:Mice, Inbred BALB C; D053769:Nanocapsules / Q000008:administration & dosage* / Q000737:chemistry / Q000648:ultrastructure; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D010316:Particle Size; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000737:chemistry; D014025:Titanium / Q000008:administration & dosage* / Q000737:chemistry; D016896:Treatment Outcome
chemical_list: D000903:Antibiotics, Antineoplastic; D003692:Delayed-Action Preparations; D058185:Magnetite Nanoparticles; D053769:Nanocapsules; D017319:Photosensitizing Agents; C009495:titanium dioxide; D004317:Doxorubicin; D014025:Titanium
keywords: pH-Sensitive; phototherapy; tumor targeting