title: Antibiotic resistance patterns of Gram-negative and Gram-positive strains isolated from inpatients with nosocomial infections in a tertiary hospital in Beijing, China from 2011 to 2014.
abstract: This study was to evaluate the resistance of antimicrobial agents against pathogens from inpatients with nosocomial infection collected in Beijing, China, during 2011-2014. Measurement of minimum inhibitory concentrations (MICs) was carried out using the broth microdilution method with the Clinical and Laboratory Standards Institute (CLSI) guidelines as the indicator. A total of 5442 Gram-negative and 806 Gram-positive isolates were collected in this study in 2011-2014. Two carbapenem-resistant strains appeared among Escherichia coli (E. coli), while imipenem-resistant isolates increased in proportion from 0% to 8.2% among Klebsiella pneumonia (K. pneumonia) during 4 year. Acinetobacter baumannii (A. baumannii) revealed severe antibacterial resistance to most antimicrobial agents. In contrast, a decreasing trend on resistance had been observed among Pseudomonas aeruginosa (P. aeruginosa) especially after 2012, range from 1.8% for co-trimoxazole to 13.5% for piperacillin. The resistance of Staphylococcus aureus (S. aureus) also had the lowest resistant to linezolid and vancomycin (0.1%). In summary, antimicrobial-resistant nosocomial pathogens have gradually increased from 2011 to 2014, so improved surveillance of hospital-acquired infections and effective infection-control measures may be the best way to solve the present problem.
authors.affiliation: a Department of Clinical Laboratory , Chinese PLA 309 Hospital , Beijing , China.|b Graduate School, Hebei North University , Zhangjiakou , Hebei , China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Zhu
authors.affiliation: a Department of Clinical Laboratory , Chinese PLA 309 Hospital , Beijing , China.
authors.forename: Aihua
authors.initials: A
authors.lastname: Tong
authors.affiliation: a Department of Clinical Laboratory , Chinese PLA 309 Hospital , Beijing , China.
authors.forename: Di
authors.initials: D
authors.lastname: Wang
authors.affiliation: a Department of Clinical Laboratory , Chinese PLA 309 Hospital , Beijing , China.|b Graduate School, Hebei North University , Zhangjiakou , Hebei , China.
authors.forename: Huijie
authors.initials: H
authors.lastname: Sun
authors.affiliation: c Graduate School , Shanxi Medical University , Taiyuan, Shanxi , China.|d Department of Plastic Surgery and Burn Repair , Chinese PLA 309 Hospital , Beijing , China.
authors.forename: Ling
authors.initials: L
authors.lastname: Chen
authors.affiliation: a Department of Clinical Laboratory , Chinese PLA 309 Hospital , Beijing , China.|b Graduate School, Hebei North University , Zhangjiakou , Hebei , China.
authors.forename: Mei
authors.initials: M
authors.lastname: Dong
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002681:China; D003428:Cross Infection / Q000382:microbiology*; D024881:Drug Resistance, Bacterial / Q000187:drug effects*; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy*; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy*; D006801:Humans; D007297:Inpatients; D008826:Microbial Sensitivity Tests / Q000379:methods; D062606:Tertiary Care Centers
chemical_list: D000900:Anti-Bacterial Agents
keywords: Antimicrobial resistance; Carbapenem resistance; Nosocomial Infection; Surveillance