title: Roles of IL-33 in Resistance and Tolerance to Systemic Candida albicans Infections.
abstract: IL-33 is a multifunctional cytokine that is released in response to a variety of intrinsic and extrinsic stimuli. The role of IL-33 in Candida albicans infections is just beginning to be revealed. This cytokine has beneficial effects on host defense against systemic C. albicans infections, and it promotes resistance mechanisms by which the immune system eliminates the invading fungal pathogens; and it also elevates host tolerance by reducing the inflammatory response and thereby, potentially, tissue damage. Thus, IL-33 is classified as a cytokine that has evolved functionally to protect the host from damage by pathogens and immunopathology.
authors.affiliation: Department of Surgery, Ulsan University Hospital, School of Medicine, University of Ulsan, Ulsan 44033, Korea.; Biomedical Research Center, Ulsan University Hospital, School of Medicine, University of Ulsan, Ulsan 44033, Korea.
authors.forename: Sang Jun
authors.initials: SJ
authors.lastname: Park
authors.affiliation: Department of Surgery, Ulsan University Hospital, School of Medicine, University of Ulsan, Ulsan 44033, Korea.; Biomedical Research Center, Ulsan University Hospital, School of Medicine, University of Ulsan, Ulsan 44033, Korea.
authors.forename: Hong Rae
authors.initials: HR
authors.lastname: Cho
authors.affiliation: Biomedical Research Center, Ulsan University Hospital, School of Medicine, University of Ulsan, Ulsan 44033, Korea.; School of Biological Sciences, University of Ulsan, Ulsan 44610, Korea.
authors.forename: Byungsuk
authors.initials: B
authors.lastname: Kwon
keywords: Candida albicans; IL-33; Resistance; Tolerance