title: RETRACTED: Magnetic Properties of Polyvinyl Alcohol and Doxorubicine Loaded Iron Oxide Nanoparticles for Anticancer Drug Delivery Applications.
abstract: The current study emphasizes the synthesis of iron oxide nanoparticles (IONPs) and impact of hydrophilic polymer polyvinyl alcohol (PVA) coating concentration as well as anticancer drug doxorubicin (DOX) loading on saturation magnetization for target drug delivery applications. Iron oxide nanoparticles particles were synthesized by a reformed version of the co-precipitation method. The coating of polyvinyl alcohol along with doxorubicin loading was carried out by the physical immobilization method. X-ray diffraction confirmed the magnetite (Fe3O4) structure of particles that remained unchanged before and after polyvinyl alcohol coating and drug loading. Microstructure and morphological analysis was carried out by transmission electron microscopy revealing the formation of nanoparticles with an average size of 10 nm with slight variation after coating and drug loading. Transmission electron microscopy, energy dispersive, and Fourier transform infrared spectra further confirmed the conjugation of polymer and doxorubicin with iron oxide nanoparticles. The room temperature superparamagnetic behavior of polymer-coated and drug-loaded magnetite nanoparticles were studied by vibrating sample magnetometer. The variation in saturation magnetization after coating evaluated that a sufficient amount of polyvinyl alcohol would be 3 wt. % regarding the externally controlled movement of IONPs in blood under the influence of applied magnetic field for in-vivo target drug delivery.
authors.affiliation: Physics Department, Faculty of Science, Universiti Teknologi Malaysia (UTM), Skudai-81310, Johor, Malaysia.|Center of Excellence in Solid State Physics, University of the Punjab, Lahore, 54590, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Nadeem
authors.affiliation: Department of Medical Physics, Institute of Nuclear Medicine and Oncology (INMOL), Lahore, Pakistan.|Physics Department, University of Lahore, Lahore, 54600, Pakistan.
authors.forename: Munir
authors.initials: M
authors.lastname: Ahmad
authors.affiliation: Divison of Science and Technology, University of Education, Township Campus, Lahore, Pakistan.
authors.forename: Muhammad Saeed
authors.initials: MS
authors.lastname: Akhtar
authors.affiliation: Physics Department, Faculty of Science, Universiti Teknologi Malaysia (UTM), Skudai-81310, Johor, Malaysia.
authors.forename: Amiruddin
authors.initials: A
authors.lastname: Shaari
authors.affiliation: Center of Excellence in Solid State Physics, University of the Punjab, Lahore, 54590, Pakistan.
authors.forename: Saira
authors.initials: S
authors.lastname: Riaz
authors.affiliation: Center of Excellence in Solid State Physics, University of the Punjab, Lahore, 54590, Pakistan.
authors.forename: Shahzad
authors.initials: S
authors.lastname: Naseem
authors.affiliation: Department of Oncology, Institute of Nuclear Medicine and Oncology (INMOL), Lahore, Pakistan.
authors.forename: Misbah
authors.initials: M
authors.lastname: Masood
authors.affiliation: Physics Department, Faculty of Science, Universiti Teknologi Malaysia (UTM), Skudai-81310, Johor, Malaysia.
authors.forename: M A
authors.initials: MA
authors.lastname: Saeed
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000737:chemistry; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry; D005290:Ferric Compounds / Q000737:chemistry; D060526:Magnetic Fields; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D011142:Polyvinyl Alcohol / Q000737:chemistry
chemical_list: D000903:Antibiotics, Antineoplastic; D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; C000499:ferric oxide; D004317:Doxorubicin; D011142:Polyvinyl Alcohol