title: Four-Component Reaction for the Synthesis of Dithiocarbamates Starting from Cyclic Imines.
abstract: An efficient one-pot, four-component reaction for the synthesis of dithiocarbamates using carbon disulfide, cyclic imines, acid chlorides, and commercially available primary or secondary amines has been developed by performing an acid chloride addition to a heterocyclic imine followed by subsequent nucleophilic substitution of in situ generated dithiocarbamic acid. With the aid of the newly developed and powerful multicomponent reaction, a direct route for the synthesis of 24 unknown dithiocarbamates in moderate to good yield under mild conditions is enabled.
authors.affiliation: Institut of Chemistry, University of Oldenburg , Carl-von-Ossietzky-Strasse 9-11, 26129 Oldenburg, Germany.
authors.forename: Torben
authors.initials: T
authors.lastname: Schlüter
authors.affiliation: Faculty of Chemistry, Kharazmi University , P.O. Box 15719-14911, 49 Mofateh Street, Tehran 31979-37551, Iran.
authors.forename: Azim
authors.initials: A
authors.lastname: Ziyaei Halimehjani
authors.affiliation: Institut of Chemistry, University of Oldenburg , Carl-von-Ossietzky-Strasse 9-11, 26129 Oldenburg, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Wachtendorf
authors.affiliation: Institut of Chemistry, University of Oldenburg , Carl-von-Ossietzky-Strasse 9-11, 26129 Oldenburg, Germany.
authors.forename: Marc
authors.initials: M
authors.lastname: Schmidtmann
authors.affiliation: Institut of Chemistry, University of Oldenburg , Carl-von-Ossietzky-Strasse 9-11, 26129 Oldenburg, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Martens
mesh_terms: D000588:Amines / Q000737:chemistry; D002246:Carbon Disulfide / Q000737:chemistry*; D062845:Chloroacetates / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D007097:Imines / Q000737:chemistry*; D015394:Molecular Structure; D054852:Small Molecule Libraries / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013859:Thiocarbamates / Q000138:chemical synthesis*
chemical_list: D000588:Amines; D062845:Chloroacetates; D007097:Imines; D054852:Small Molecule Libraries; D013859:Thiocarbamates; D002246:Carbon Disulfide
keywords: carbon disulfide; cyclic imines; dithiocarbamates; multicomponent reaction; one pot