title: Frequency Mixing Magnetic Detection Scanner for Imaging Magnetic Particles in Planar Samples.
abstract: The setup of a planar Frequency Mixing Magnetic Detection (p-FMMD) scanner for performing Magnetic Particles Imaging (MPI) of flat samples is presented. It consists of two magnetic measurement heads on both sides of the sample mounted on the legs of a u-shaped support. The sample is locally exposed to a magnetic excitation field consisting of two distinct frequencies, a stronger component at about 77 kHz and a weaker field at 61 Hz. The nonlinear magnetization characteristics of superparamagnetic particles give rise to the generation of intermodulation products. A selected sum-frequency component of the high and low frequency magnetic field incident on the magnetically nonlinear particles is recorded by a demodulation electronics. In contrast to a conventional MPI scanner, p-FMMD does not require the application of a strong magnetic field to the whole sample because mixing of the two frequencies occurs locally. Thus, the lateral dimensions of the sample are just limited by the scanning range and the supports. However, the sample height determines the spatial resolution. In the current setup it is limited to 2 mm. As examples, we present two 20 mm × 25 mm p-FMMD images acquired from samples with 1 µm diameter maghemite particles in silanol matrix and with 50 nm magnetite particles in aminosilane matrix. The results show that the novel MPI scanner can be applied for analysis of thin biological samples and for medical diagnostic purposes.
authors.affiliation: Advanced Vision System Research Section, Electronics & Telecommunication Research Institute (ETRI); HB8868@etri.re.kr.
authors.forename: Hyobong
authors.initials: H
authors.lastname: Hong
authors.affiliation: Intelligent Cognitive Technology Research Department, Electronics & Telecommunication Research Institute (ETRI).
authors.forename: Eul-Gyoon
authors.initials: EG
authors.lastname: Lim
authors.affiliation: Advanced Vision System Research Section, Electronics & Telecommunication Research Institute (ETRI).
authors.forename: Jae-Chan
authors.initials: JC
authors.lastname: Jeong
authors.affiliation: Advanced Vision System Research Section, Electronics & Telecommunication Research Institute (ETRI).
authors.forename: Jiho
authors.initials: J
authors.lastname: Chang
authors.affiliation: Intelligent Cognitive Technology Research Department, Electronics & Telecommunication Research Institute (ETRI).
authors.forename: Sung-Woong
authors.initials: SW
authors.lastname: Shin
authors.affiliation: Peter Grünberg Institute (PGI-8), Forschungszentrum Jülich.
authors.forename: Hans-Joachim
authors.initials: HJ
authors.lastname: Krause
mesh_terms: D060526:Magnetic Fields; D008280:Magnetics; D019047:Phantoms, Imaging