title: Is preterm delivery an independent risk factor for long-term maternal kidney disease?
abstract: OBJECTIVE
  To investigate whether women who had a preterm delivery (PTD) are at an increased risk of subsequent long term maternal kidney disease.
  
  
  METHODS
  A population-based study compared the incidence of long-term maternal kidney disease in a cohort of women with and without previous PTD. Deliveries occurred during a 25 years period, with a mean follow-up duration of 11.2 years.
  
  
  RESULTS
  Of 99 338 deliveries of women, 16 364 (16.4%) occurred in patients who had at least one PTD. A significant dose response was found between the number of previous PTDs and the gestational age at birth of the PTDs and future risk for renal-related hospitalizations. Patients with either spontaneous or indicated PTD had higher rates of renal-related hospitalizations (0.2% versus 0.1% OR= 2.6; 95%CI: 1.7-3.9, p  <0.001 and 0.5% versus 0.2% OR 3.41; 95%CI: 1.7-6.5, p  < 0.001, respectively). In a Cox proportional hazards model, PTD was independently associated with long-term maternal renal-related hospitalizations.
  
  
  CONCLUSIONS
  PTD is an independent risk factor for long-term maternal kidney disease.
authors.affiliation: a Department of Obstetrics and Gynecology , Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev , Beer-Sheva , Israel and.
authors.forename: Gali
authors.initials: G
authors.lastname: Pariente
authors.affiliation: a Department of Obstetrics and Gynecology , Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev , Beer-Sheva , Israel and.
authors.forename: Roy
authors.initials: R
authors.lastname: Kessous
authors.affiliation: b Department of Epidemiology and Health Services Evaluation , Ben-Gurion University of the Negev , Beer-Sheva , Israel.
authors.forename: Ruslan
authors.initials: R
authors.lastname: Sergienko
authors.affiliation: a Department of Obstetrics and Gynecology , Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev , Beer-Sheva , Israel and.
authors.forename: Eyal
authors.initials: E
authors.lastname: Sheiner
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D005865:Gestational Age; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D007674:Kidney Diseases / Q000453:epidemiology* / Q000209:etiology; D008137:Longitudinal Studies; D011247:Pregnancy; D047928:Premature Birth / Q000453:epidemiology*; D016016:Proportional Hazards Models; D012307:Risk Factors
keywords: Kidney; long term; maternal outcomes; preterm delivery