title: Delineating potential epileptogenic areas utilizing resting functional magnetic resonance imaging (fMRI) in epilepsy patients.
abstract: Seizure localization includes neuroimaging like electroencephalogram, and magnetic resonance imaging (MRI) with limited ability to characterize the epileptogenic network. Temporal clustering analysis (TCA) characterizes epileptogenic network congruent with interictal epileptiform discharges by clustering together voxels with transient signals. We generated epileptogenic areas for 12 of 13 epilepsy patients with TCA, congruent with different areas of seizure onset. Resting functional MRI (fMRI) scans are noninvasive, and can be acquired quickly, in patients with different levels of severity and function. Analyzing resting fMRI data using TCA is quick and can complement clinical methods to characterize the epileptogenic network.
authors.affiliation: a Department of Biomedical Engineering , UW-Madison , Madison , WI , USA.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Pizarro
authors.affiliation: b Department of Radiology , UW-Madison , Madison , WI , USA.
authors.forename: Veena
authors.initials: V
authors.lastname: Nair
authors.affiliation: b Department of Radiology , UW-Madison , Madison , WI , USA.
authors.forename: Timothy
authors.initials: T
authors.lastname: Meier
authors.affiliation: b Department of Radiology , UW-Madison , Madison , WI , USA.
authors.forename: Ryan
authors.initials: R
authors.lastname: Holdsworth
authors.affiliation: c Department of Neurology , UW-Madison , Madison , WI , USA.
authors.forename: Evelyn
authors.initials: E
authors.lastname: Tunnell
authors.affiliation: c Department of Neurology , UW-Madison , Madison , WI , USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Rutecki
authors.affiliation: d Department of Neurosurgery , UW-Madison , Madison , WI , USA.
authors.forename: Karl
authors.initials: K
authors.lastname: Sillay
authors.affiliation: a Department of Biomedical Engineering , UW-Madison , Madison , WI , USA.|e Department of Medical Physics , UW-Madison , Madison , WI , USA.
authors.forename: Mary E
authors.initials: ME
authors.lastname: Meyerand
authors.affiliation: b Department of Radiology , UW-Madison , Madison , WI , USA.
authors.forename: Vivek
authors.initials: V
authors.lastname: Prabhakaran
mesh_terms: D000328:Adult; D004569:Electroencephalography; D004827:Epilepsy / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D059907:Functional Neuroimaging / Q000379:methods*; D006624:Hippocampus / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology
keywords: Epilepsy; electroencephalogram; resting function magnetic resonance imaging; seizure foci localization; temporal clustering analysis