title: Dianthosaponins G-I, triterpene saponins, an anthranilic acid amide glucoside and a flavonoid glycoside from the aerial parts of Dianthus japonicus and their cytotoxicity.
abstract: Extensive isolation work on the 1-BuOH-soluble fraction of a MeOH extract of the aerial parts of Dianthus japonicus afforded three further triterpene glycosyl estsers, termed dianthosaponins G-I, an anthranilic acid amide glucoside and a C-glycosyl flavonoid along with one known triterpene saponin. Their structures were elucidated from spectroscopic evidence. The cytotoxicity of the isolated compounds toward A549 cells was evaluated.
authors.affiliation: Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Kanehira
authors.affiliation: Department of Natural Product Chemistry, Faculty of Pharmacy, Yasuda Women's University, 6-13-1 Yasuhigashi, Asaminami-ku, Hiroshima, 731-0153, Japan.
authors.forename: Susumu
authors.initials: S
authors.lastname: Kawakami
authors.affiliation: Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.
authors.forename: Sachiko
authors.initials: S
authors.lastname: Sugimoto
authors.affiliation: Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Matsunami
authors.affiliation: Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan. hotsuka@hiroshima-u.ac.jp.|Department of Natural Product Chemistry, Faculty of Pharmacy, Yasuda Women's University, 6-13-1 Yasuhigashi, Asaminami-ku, Hiroshima, 731-0153, Japan. hotsuka@hiroshima-u.ac.jp.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Otsuka
mesh_terms: D000072283:A549 Cells; D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000188:drug therapy; D000577:Amides / Q000737:chemistry; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D029749:Dianthus / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D008517:Phytotherapy; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D062367:ortho-Aminobenzoates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000577:Amides; D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D005960:Glucosides; D006027:Glycosides; D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes; C000615794:dianthosaponin G; C000615795:dianthosaponin H; C000615796:dianthosaponin I; D062367:ortho-Aminobenzoates; C031385:anthranilic acid
keywords: Anthranilic acid amide glucoside; Caryophyllaceae; Dianthus japonicus; Flavonoid glycoside; Oleanane; Triterpene saponin