title: Yttrium-90 radioembolization for unresectable/recurrent intrahepatic cholangiocarcinoma: a survival, efficacy and safety study.
abstract: Intrahepatic cholangiocarcinoma (ICC) is a rapidly progressing malignancy; only a minority of the tumours can be resected and the palliative regimens have shown limited success. The aim of this study was to assess overall survival (OS), tumour response and the safety of radioembolization with yttrium-90 ((90)Y-TARE) in patients with unresectable/recurrent ICC.
  
  
  
  Survival was calculated from the date of the (90)Y-TARE procedure. Target and overall Response Evaluation Criteria in Solid Tumors (RECIST) and modified RECIST (mRECIST) and European Association for the Study of the Liver (EASL)-measuring delayed-phase contrast enhancement-treatment responses were assessed at 3 months.
  
  
  
  The overall median survival was 17.9 months (95% CI: 14.3-21.4 months). Significantly longer survival was obtained in naive patients as compared with patients in whom TARE was preceded by other treatments, including surgery (52 vs 16 months, P=0.009). Significantly prolonged OS was recorded for patients with a response based on mRECIST and the EASL criteria while RECIST responses were not found to be associated with survival. Treatment was well-tolerated, and no mortality was reported within 30 days.
  
  
  
  In unresectable ICC, (90)Y-TARE is safe and offers a survival benefit in naive patients, as well as in responders.
authors.affiliation: Radiology Unit, Department of Diagnostic and Preventive Medicine, S. Orsola-Malpighi University Hospital, 40138 Bologna, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Mosconi
authors.affiliation: Department of Medical and Surgical Sciences, Alma Mater Studiorum-University of Bologna, 40138 Bologna, Italy.
authors.forename: Annagiulia
authors.initials: A
authors.lastname: Gramenzi
authors.affiliation: Radiology Unit, Department of Diagnostic and Preventive Medicine, S. Orsola-Malpighi University Hospital, 40138 Bologna, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Ascanio
authors.affiliation: Radiology Unit, Department of Diagnostic and Preventive Medicine, S. Orsola-Malpighi University Hospital, 40138 Bologna, Italy.
authors.forename: Alberta
authors.initials: A
authors.lastname: Cappelli
authors.affiliation: Radiology Unit, Department of Diagnostic and Preventive Medicine, S. Orsola-Malpighi University Hospital, 40138 Bologna, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Renzulli
authors.affiliation: Medical Physics Unit, Radiology Unit, S. Orsola-Malpighi Hospital, 40138 Bologna, Italy.
authors.forename: Cinzia
authors.initials: C
authors.lastname: Pettinato
authors.affiliation: Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum - University of Bologna, 40138 Bologna, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Brandi
authors.affiliation: Radiation Oncology Unit, Department of Oncology and Hematology, S. Orsola-Malpighi Hospital, 40138 Bologna, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Monari
authors.affiliation: Department of Medical and Surgical Sciences, S. Orsola-Malpighi Hospital, Alma Mater Studiorum-University of Bologna, 40138 Bologna, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Cucchetti
authors.affiliation: Department of Medical and Surgical Sciences, Alma Mater Studiorum-University of Bologna, 40138 Bologna, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Trevisani
authors.affiliation: Radiology Unit, Department of Diagnostic and Preventive Medicine, S. Orsola-Malpighi University Hospital, 40138 Bologna, Italy.
authors.forename: Rita
authors.initials: R
authors.lastname: Golfieri
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001650:Bile Duct Neoplasms / Q000532:radiotherapy*; D018281:Cholangiocarcinoma / Q000532:radiotherapy*; D004621:Embolization, Therapeutic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D016019:Survival Analysis; D015021:Yttrium Radioisotopes / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D015021:Yttrium Radioisotopes