title: Acquired dermal melanocytosis of the face and extremities.
abstract: Acquired dermal melanocytosis (ADM) is a relatively rare, but well-described disease among adolescent to middle-aged East Asian women, particularly those of Japanese and Chinese descent. Clinically, ADM manifests as multiple punctate and greyish-brown pigmented areas 1-3 mm in diameter occurring on both sides of the forehead and zygomatic region. The subtype of ADM affecting the face and extremities is extremely rare even in East Asian women. We describe three patients with ADM of the face and extremities (ADMFE) and their characteristic clinical features. All patients were Japanese women, and showed multiple greyish-brown pigmentations on both nasal wings and on the extensor surface of the extremities. We found that the clinical features were strikingly uniform, and that a pigmented lesion on the nasal wing can be an important clue to distinguish ADMFE from other hyperpigmented diseases of the hands and feet. One patient was treated with Q-switched ruby laser with excellent outcome. Increased awareness of ADMFE can lead to earlier diagnosis and potential treatment.
authors.affiliation: Department of Dermatology, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ouchi
authors.affiliation: Department of Dermatology, School of Medicine, Keio University, Tokyo, Japan.|Department of Dermatology, School of Medicine, Faculty of Medicine, Toho University, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ishii
authors.affiliation: Department of Dermatology, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nishikawa
authors.affiliation: Department of Dermatology, School of Medicine, Keio University, Tokyo, Japan.|Department of Dermatology, School of Medicine, Faculty of Medicine, Toho University, Tokyo, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Ishiko
mesh_terms: D000328:Adult; D044466:Asian People; D005145:Face / Q000473:pathology*; D005260:Female; D006225:Hand / Q000473:pathology*; D006801:Humans; D017495:Hyperpigmentation / Q000473:pathology; D053685:Laser Therapy / Q000379:methods; D008544:Melanocytes / Q000473:pathology*; D008548:Melanosis / Q000473:pathology* / Q000628:therapy; D035583:Rare Diseases; D012878:Skin Neoplasms / Q000473:pathology; D016896:Treatment Outcome