title: The effects of calorie restriction on aging: a brief review.
abstract: Calorie restriction (CR) without malnutrition slows aging and increase average and maximal lifespan in model organisms and rodents. In human and non-human primates, CR has beneficial effects on human longevity and reduces the incidence of age-related diseases such as obesity, diabetes mellitus hypertension, cardiovascular disease and cancer. CR exerts its anti-aging effects through different mechanisms including small noncoding RNA molecules (sncRNAs), the composition of diet and IGF-1 signaling. The aim of this review was to discuss recent developments to understand the consequences and mechanisms of CR on longevity.
authors.affiliation: Department of Physiology, Aging Research Chair, College of Medicine, King Saud University, Riyadh, Saudi Arabia. kalregaiey@ksu.edu.sa.
authors.forename: K A
authors.initials: KA
authors.lastname: Al-Regaiey
mesh_terms: D000375:Aging; D000818:Animals; D031204:Caloric Restriction; D002318:Cardiovascular Diseases / Q000517:prevention & control; D006801:Humans; D008136:Longevity; D011323:Primates