title: 1, 8-Cineol Protect Against Influenza-Virus-Induced Pneumonia in Mice.
abstract: 1,8-Cineol is a major monoterpene principally from eucalyptus essential oils and has been shown to exert anti-inflammatory, antiviral, and inhibitory of nuclear factor (NF)-kB effect. In the present study, we evaluated the effect of 1,8-cineol on mice infected with influenza A virus. We found that 1,8-cineol protects against influenza viral infection in mice. Moreover, 1,8-cineol efficiently decreased the level of IL-4, IL-5, IL-10, and MCP-1 in nasal lavage fluids and the level of IL-1β, IL-6, TNF-α, and IFN-γ in lung tissues of mice infected with influenza virus. The results also showed that 1,8-cineol reduced the expression of NF-kB p65, intercellular adhesion molecule (ICAM)-1, and vascular cell adhesion molecule (VCAM)-1 in lung tissues. Thus, 1,8-cineol appears to be able to augment protection against IFV infection in mice via attenuation of pulmonary inflammatory responses.
authors.affiliation: Institute of Tropical Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Rd., San Yuanli St., Bai Yun Dist., Guangzhou, Guangdong, 510405, People's Republic of China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Li
authors.affiliation: Institute of Tropical Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Rd., San Yuanli St., Bai Yun Dist., Guangzhou, Guangdong, 510405, People's Republic of China.
authors.forename: Yanni
authors.initials: Y
authors.lastname: Lai
authors.affiliation: Institute of Tropical Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Rd., San Yuanli St., Bai Yun Dist., Guangzhou, Guangdong, 510405, People's Republic of China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Institute of Tropical Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Rd., San Yuanli St., Bai Yun Dist., Guangzhou, Guangdong, 510405, People's Republic of China.
authors.forename: Ni
authors.initials: N
authors.lastname: Liu
authors.affiliation: Institute of Tropical Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Rd., San Yuanli St., Bai Yun Dist., Guangzhou, Guangdong, 510405, People's Republic of China.
authors.forename: Fengxue
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Institute of Tropical Medicine, Guangzhou University of Chinese Medicine, 12 Jichang Rd., San Yuanli St., Bai Yun Dist., Guangzhou, Guangdong, 510405, People's Republic of China. xupeiping@gzucm.edu.cn.
authors.forename: Peiping
authors.initials: P
authors.lastname: Xu
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents; D003511:Cyclohexanols / Q000494:pharmacology*; D000077591:Eucalyptol; D007249:Inflammation / Q000188:drug therapy; D029521:Alphainfluenzavirus; D051379:Mice; D039821:Monoterpenes / Q000494:pharmacology*; D009976:Orthomyxoviridae Infections / Q000150:complications; D011014:Pneumonia / Q000188:drug therapy / Q000517:prevention & control* / Q000821:virology
chemical_list: D000890:Anti-Infective Agents; D003511:Cyclohexanols; D039821:Monoterpenes; D000077591:Eucalyptol
keywords: 1,8-cineol; inflammatory cytokines; influenza A virus; viral pneumonia