title: Functional analysis of anomeric sugar kinases.
abstract: Anomeric sugar kinases perform fundamental roles in the metabolism of carbohydrates. Under- or overexpression of these enzymes, or mutations causing functional impairments can give rise to diseases such as galactosaemia and so the study of this class of kinase is of critical importance. In addition, anomeric sugar kinases which are naturally promiscuous, or have been artificially made so, may find application in the synthesis of libraries of drug candidates (for example, antibiotics), and natural or unnatural oligosaccharides and glycoconjugates. In this review, we provide an overview of the biological functions of these enzymes, the tools which have been developed to investigate them, and the current frontiers in their study.
authors.affiliation: Glycomics and Glycan Bioengineering Research Center (GGBRC), College of Food Science and Technology, Nanjing Agricultural University, Nanjing, China.
authors.forename: Louis P
authors.initials: LP
authors.lastname: Conway
authors.affiliation: Glycomics and Glycan Bioengineering Research Center (GGBRC), College of Food Science and Technology, Nanjing Agricultural University, Nanjing, China. Electronic address: josef.voglmeir@njau.edu.cn.
authors.forename: Josef
authors.initials: J
authors.lastname: Voglmeir
mesh_terms: D000818:Animals; D001419:Bacteria / Q000201:enzymology; D002241:Carbohydrates / Q000737:chemistry*; D020134:Catalytic Domain; D004789:Enzyme Activation; D005658:Fungi / Q000201:enzymology; D005686:Galactokinase / Q000737:chemistry / Q000378:metabolism*; D006593:Hexokinase / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D013379:Substrate Specificity
chemical_list: D002241:Carbohydrates; D006593:Hexokinase; D005686:Galactokinase
keywords: Galactokinase; Kinase assay; Sugar kinase