title: Treatment of pulmonary exacerbations in cystic fibrosis - could do better?
abstract: This article describes the nature and significance of pulmonary exacerbations in cystic fibrosis (CF). The effectiveness and safety of current exacerbation treatment are explored. The article concludes with a summary of clinical trials (completed and ongoing) which aim to improve the efficacy and safety of exacerbation treatment.
authors.affiliation: School of Medicine, University of Nottingham. Electronic address: alan.smyth@nottingham.ac.uk.
authors.forename: Alan
authors.initials: A
authors.lastname: Smyth
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003550:Cystic Fibrosis / Q000150:complications* / Q000382:microbiology; D018450:Disease Progression; D006801:Humans; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000382:microbiology; D012307:Risk Factors
chemical_list: D000900:Anti-Bacterial Agents
keywords: Adverse effects of antibiotics; Cystic fibrosis; Microbiome; Pulmonary exacerbations; Symptom score