title: AMPK Regulation of Glucose, Lipid and Protein Metabolism: Mechanisms and Nutritional Significance.
abstract: AMP-activated protein kianse (AMPK) is a master sensor of cellular energy levels and a crucial regulator of nutrient metabolism such as the synthesis of fatty acids, glucose and protein as well as their oxidation to CO2 and water . Thus, AMPK signaling has important implications for fat deposition and glucose homeostasis in animals and humans. Much experimental and clinical evidence show that AMPK is a key therapeutic target for the prevention of diseases such as obesity, diabetes, cancer, inflammation and cardiac dysfunction. In this review we highlight recent advances on the upstream and downstream targets of AMPK, as well as the specific mechanisms whereby AMPK regulates digestive functions and chronic energy balance in animals and humans.
authors.affiliation: Key Laboratory of Agro-ecological Processes in Subtropical Region, Hunan Provincial Engineering Research Center of Healthy Livestock, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South- Central, Ministry of Agriculture, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, Hunan, 410125. China.
authors.forename: Liuqin
authors.initials: L
authors.lastname: He
authors.affiliation: Key Laboratory of Agro-ecological Processes in Subtropical Region, Hunan Provincial Engineering Research Center of Healthy Livestock, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South- Central, Ministry of Agriculture, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, Hunan, 410125. China.
authors.forename: Xihong
authors.initials: X
authors.lastname: Zhou
authors.affiliation: College Of Animal Science And Technology, Hunan Agricultural University, Hunan. China.
authors.forename: Niu
authors.initials: N
authors.lastname: Huang
authors.affiliation: College Of Animal Science And Technology, Hunan Agricultural University, Hunan. China.
authors.forename: Huan
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Animal Science And Technology, Huazhong Agricultural University, Hubei. China.
authors.forename: Junquan
authors.initials: J
authors.lastname: Tian
authors.affiliation: Hunan Co-Innovation Center of Animal Production Safety, Changsha, Hunan. China.
authors.forename: Tiejun
authors.initials: T
authors.lastname: Li
authors.affiliation: Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Changsha, Hunan, 410125. China.
authors.forename: Kang
authors.initials: K
authors.lastname: Yao
authors.affiliation: Department of Animal Science, University of Manitoba, Winnipeg, Manitoba. Canada.
authors.forename: Clares M
authors.initials: CM
authors.lastname: Nyachoti
authors.affiliation: Department of Animal Science, North Carolina State University, NC. United States.
authors.forename: Sung Woo
authors.initials: SW
authors.lastname: Kim
authors.affiliation: Key Laboratory of Agro-ecological Processes in Subtropical Region, Hunan Provincial Engineering Research Center of Healthy Livestock, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South- Central, Ministry of Agriculture, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, Hunan, 410125. China.
authors.forename: Yulong
authors.initials: Y
authors.lastname: Yin
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism*; D000818:Animals; D004063:Digestion; D004734:Energy Metabolism; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism; D011506:Proteins / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D011506:Proteins; D055372:AMP-Activated Protein Kinases; D005947:Glucose
keywords: AMPK; glucose; lipid; protein; regulation