title: Brain Invasion in Meningiomas: Incidence and Correlations with Clinical Variables and Prognosis.
abstract: OBJECTIVE
  In meningioma, correlation of brain invasion with prognosis and clinical variables remains controversial.
  
  
  METHODS
  Correlation of brain invasion with clinical and histopathologic variables was investigated in 467 patients with primary intracranial meningioma.
  
  
  RESULTS
  Diffuse (n = 3; 10%), clusterlike (n = 11; 34%) or fingerlike (n = 18; 56%) invasion was detected in 32 patients (7%). Brain invasion was more common in males than in females (13% vs. 5%; odds ratio, 2.75; 95% confidence interval, 1.29-5.89; P = 0.009) and pattern of invasion differed between genders (P = 0.037). Brain invasion was absent in 401 benign meningiomas and present in 48% of 60 atypical (n = 29) and 50% of 6 anaplastic (n = 3) meningiomas (P < 0.001) but was independent of tumor location and extent of resection. Progression occurred in 11% and was more frequent (31% vs. 15%; P = 0.036) in invasive than in noninvasive tumors, but only after gross total resection and in univariate analyses, and independent of invasion pattern. In atypical meningiomas, frequency of adjuvant irradiation was similar comparing invasive and noninvasive tumors and grading solely based on brain invasion (n = 20; 33%), other World Health Organization (WHO) criteria (n = 31; 52%) or a combination of both (n = 9; 15%). Risk of recurrence was lower (hazard ratio, 0.258, 95% confidence interval, 0.09-0.734; P = 0.011) when grading exclusively based on brain invasion than when further WHO criteria were in addition present and the progression-free interval among the first was similar to benign tumors.
  
  
  CONCLUSIONS
  Brain invasion and its patterns are correlated to gender. In contrast to the current WHO classification, invasion was associated with recurrence only after gross total resection and not independent of further histopathologic criteria of atypia.
authors.affiliation: Institute of Neuropathology, University Hospital Münster, Münster, Germany.
authors.forename: Dorothee Cäcilia
authors.initials: DC
authors.lastname: Spille
authors.affiliation: Institute of Neuropathology, University Hospital Münster, Münster, Germany.
authors.forename: Katharina
authors.initials: K
authors.lastname: Heß
authors.affiliation: Institute of Biostatistics and Clinical Research, University Hospital Münster, Münster, Germany.
authors.forename: Cristina
authors.initials: C
authors.lastname: Sauerland
authors.affiliation: Barrow Brain Tumor Research Center, Barrow Neurological Institute, 350 West Thomas Rd, Phoenix, Arizona, USA.
authors.forename: Nader
authors.initials: N
authors.lastname: Sanai
authors.affiliation: Department of Neurosurgery, University Hospital Münster, Münster, Germany.
authors.forename: Walter
authors.initials: W
authors.lastname: Stummer
authors.affiliation: Institute of Neuropathology, University Hospital Münster, Münster, Germany.
authors.forename: Werner
authors.initials: W
authors.lastname: Paulus
authors.affiliation: Department of Neurosurgery, University Hospital Münster, Münster, Germany. Electronic address: benjamin.brokinkel@ukmuenster.de.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Brokinkel
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000473:pathology*; D002648:Child; D018572:Disease-Free Survival; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D008577:Meningeal Neoplasms / Q000401:mortality* / Q000473:pathology*; D008579:Meningioma / Q000401:mortality* / Q000473:pathology*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000401:mortality* / Q000473:pathology; D011379:Prognosis; D012307:Risk Factors; D017678:Sex Distribution; D013223:Statistics as Topic; D015996:Survival Rate; D055815:Young Adult
keywords: Brain invasion; Gender; Meningioma; Prognosis