title: In Vitro Dermo-Cosmetic Evaluation of Bark Extracts from Common Temperate Trees.
abstract: Wood residues produced from forestry activities represent an interesting source of biologically active, high value-added secondary metabolites. In this study, 30 extracts from 10 barks of deciduous and coniferous tree species were investigated for their potential dermo-cosmetic use. The extracts were obtained fromFagus sylvatica, Quercus robur, Alnus glutinosa, Prunus avium, Acer pseudoplatanus, Fraxinus excelsior, Populus robusta, Larix decidua, Picea abies, andPopulus tremulaafter three successive solid/liquid extractions of the barks withn-heptane, methanol, and methanol/water. All extracts were evaluated for their radical scavenging capacity, for their elastase, collagenase, and tyrosinase inhibitory activities, as well as for their antibacterial activity against gram-positiveStaphylococcus aureus. In parallel, the global metabolite profiles of all extracts were established by 1D and 2D NMR and related to their biological activity. The results showed that the methanol extracts ofQ. robur, A. glutinosa, L. decidua, andP. abiesbarks exhibit particularly high activities on most bioassays, suggesting their promising use as active ingredients in the dermo-cosmetic industry.
authors.affiliation: Institut de Chimie Moléculaire de Reims, UMR CNRS 7312, SFR CAP'SANTE, UFR de Pharmacie, Université de Reims Champagne-Ardenne, Reims, France.
authors.forename: Jane
authors.initials: J
authors.lastname: Hubert
authors.affiliation: Institut de Chimie Moléculaire de Reims, UMR CNRS 7312, SFR CAP'SANTE, UFR de Pharmacie, Université de Reims Champagne-Ardenne, Reims, France.
authors.forename: Apostolis
authors.initials: A
authors.lastname: Angelis
authors.affiliation: Division of Pharmacognosy and Natural Products Chemistry, School of Pharmacy, University of Athens, Panepistimioupolis, Zographou, Athens, Greece.
authors.forename: Nektarios
authors.initials: N
authors.lastname: Aligiannis
authors.affiliation: Division of Pharmacognosy and Natural Products Chemistry, School of Pharmacy, University of Athens, Panepistimioupolis, Zographou, Athens, Greece.
authors.forename: Michalea
authors.initials: M
authors.lastname: Rosalia
authors.affiliation: Institut de Chimie Moléculaire de Reims, UMR CNRS 7312, SFR CAP'SANTE, UFR de Pharmacie, Université de Reims Champagne-Ardenne, Reims, France.
authors.forename: Amin
authors.initials: A
authors.lastname: Abedini
authors.affiliation: Institut de Chimie Moléculaire de Reims, UMR CNRS 7312, SFR CAP'SANTE, UFR de Pharmacie, Université de Reims Champagne-Ardenne, Reims, France.
authors.forename: Ali
authors.initials: A
authors.lastname: Bakiri
authors.affiliation: Soliance-Givaudan, Pomacle, France.
authors.forename: Romain
authors.initials: R
authors.lastname: Reynaud
authors.affiliation: Institut de Chimie Moléculaire de Reims, UMR CNRS 7312, SFR CAP'SANTE, UFR de Pharmacie, Université de Reims Champagne-Ardenne, Reims, France.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Nuzillard
authors.affiliation: Biomatériaux et Inflammation en Site Osseux, EA 4691, SFR CAP-Santé, UFR de Pharmacie, Université de Reims Champagne Ardenne, Reims, France.
authors.forename: Sophie C
authors.initials: SC
authors.lastname: Gangloff
authors.affiliation: Division of Pharmacognosy and Natural Products Chemistry, School of Pharmacy, University of Athens, Panepistimioupolis, Zographou, Athens, Greece.
authors.forename: Alexios-Leandros
authors.initials: AL
authors.lastname: Skaltsounis
authors.affiliation: Institut de Chimie Moléculaire de Reims, UMR CNRS 7312, SFR CAP'SANTE, UFR de Pharmacie, Université de Reims Champagne-Ardenne, Reims, France.
authors.forename: Jean-Hugues
authors.initials: JH
authors.lastname: Renault
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003879:Dermatologic Agents / Q000737:chemistry / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D014197:Trees / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D003879:Dermatologic Agents; D004791:Enzyme Inhibitors; D010936:Plant Extracts; D014442:Monophenol Monooxygenase; D010196:Pancreatic Elastase