title: Concomitant transrectal ultrasound-guided biopsy and transurethral resection of prostate in patients with urinary retention and elevated serum prostate-specific antigen levels.
abstract: BACKGROUND
  There was no consensus about the management of patients with urinary retention and elevated serum prostate-specific antigen (PSA) levels. This study aimed to determine whether concomitant transrectal ultrasound (TRUS)-guided biopsy and transurethral resection of prostate (TURP) is practical in patients with urinary retention and elevated serum PSA levels.
  
  
  METHODS
  From March 2007 to May 2015, a total of 34 patients with urinary retention and elevated PSA (≥ 4 ng/mL) underwent concomitant TRUS-guided biopsy and TURP. The medical records were evaluated retrospectively, and data including PSA, prostate volume, TURP results, TRUS-guided biopsy results, length of hospitalization, and complications were collected. These patients were then compared with 40 patients with urinary retention who underwent TURP alone.
  
  
  RESULTS
  The mean age of the patients was 71.6 years. The mean PSA levels were 16.9 ng/mL. Prostate cancer was detected in eight cases (23.5%): one case by TRUS-guided biopsy alone, two cases by TURP alone, and five cases by both TRUS-guided biopsy and TURP. Complications included fever in five patients (14.7%), recatheterization for urine retention in two patients (5.9%), urinary tract infection in two patients (5.9%), and de novo urge incontinence in seven patients (20.6%). The complication rate was not significantly increased compared with that of the patients who underwent TURP alone.
  
  
  CONCLUSIONS
  This study showed that concomitant TRUS-guided biopsy and TURP was safe and of possible clinical significance in urinary retention patients with elevated serum PSA.
authors.affiliation: Department of Urology, Mackay Memorial Hospital, Taipei, Taiwan, ROC; Department of Medicine, Mackay Medical College, Taipei, Taiwan, ROC.
authors.forename: Ti-Yuan
authors.initials: TY
authors.lastname: Yang
authors.affiliation: Department of Urology, Mackay Memorial Hospital, Taipei, Taiwan, ROC; Department of Medicine, Mackay Medical College, Taipei, Taiwan, ROC. Electronic address: urodrc@hotmail.com.
authors.forename: Yung-Chiong
authors.initials: YC
authors.lastname: Chow
authors.affiliation: Department of Urology, Mackay Memorial Hospital, Taipei, Taiwan, ROC; Department of Medicine, Mackay Medical College, Taipei, Taiwan, ROC.
authors.forename: Wun-Rong
authors.initials: WR
authors.lastname: Lin
authors.affiliation: Taipei City Hospital, Taipei, Taiwan, ROC.
authors.forename: Ming-Chung
authors.initials: MC
authors.lastname: Ko
authors.affiliation: Department of Urology, Mackay Memorial Hospital, Taipei, Taiwan, ROC; Department of Medicine, Mackay Medical College, Taipei, Taiwan, ROC.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Chen
authors.affiliation: Department of Urology, Mackay Memorial Hospital, Taipei, Taiwan, ROC; Department of Medicine, Mackay Medical College, Taipei, Taiwan, ROC.
authors.forename: Huang-Kuang
authors.initials: HK
authors.lastname: Chang
authors.affiliation: Department of Urology, Mackay Memorial Hospital, Taipei, Taiwan, ROC; Department of Medicine, Mackay Medical College, Taipei, Taiwan, ROC.
authors.forename: Jong-Ming
authors.initials: JM
authors.lastname: Hsu
authors.affiliation: Department of Urology, Mackay Memorial Hospital, Taipei, Taiwan, ROC; Department of Medicine, Mackay Medical College, Taipei, Taiwan, ROC.
authors.forename: Stone
authors.initials: S
authors.lastname: Yang
authors.affiliation: Department of Urology, Mackay Memorial Hospital, Taipei, Taiwan, ROC; Department of Medicine, Mackay Medical College, Taipei, Taiwan, ROC.
authors.forename: Wen-Chou
authors.initials: WC
authors.lastname: Lin
authors.affiliation: Department of Urology, Mackay Memorial Hospital, Taipei, Taiwan, ROC; Department of Medicine, Mackay Medical College, Taipei, Taiwan, ROC; Department of Urology, School of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC.
authors.forename: Allen W
authors.initials: AW
authors.lastname: Chiu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D061705:Image-Guided Biopsy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood*; D012189:Retrospective Studies; D020728:Transurethral Resection of Prostate / Q000009:adverse effects / Q000379:methods*; D018084:Ultrasonography, Interventional; D016055:Urinary Retention / Q000601:surgery*
chemical_list: D017430:Prostate-Specific Antigen
keywords: prostate cancer; prostate-specific antigen; transrectal ultrasound-guided biopsy; transurethral resection of prostate; urinary retention