title: Concomitant sensitization to glutaraldehyde and methacrylic monomers among dentists and their patients.
abstract: BACKGROUND
  A multitude of methacrylic monomers is used in dentistry. Glutaraldehyde (G) is used in dental practice and consumer products as a broad-spectrum antimicrobial agent. The purpose of our study is to evaluate the frequency and the risk of concomitant sensitization to some methacrylic monomers (methyl methacrylate (MMA), triethyleneglycol dimethacrylate (TEGDMA), ethyleneglycol dimethacrylate (EGDMA), 2,2-bis-[4-(2-hydroxy-3-methacrylo-xypropoxy)phenyl]-propane (Bis-GMA), 2-hydroxy-ethyl methacrylate (2-HEMA) and tetrahydrofurfuryl methacrylate (THFMA)) and glutaraldehyde in students of dentistry, students from the dental technician school, dental professionals and dental patients.
  
  
  METHODS
  A total of 262 participants were included in the study: students of dentistry, students from the dental technician school, dental professionals, and dental patients as a control group. All were patch-tested with methacrylic monomers and glutaraldehyde. The results were subject to the statistical analysis (p < 0.05).
  
  
  RESULTS
  Among the group of dental students, the highest frequency of concomitant sensitization was to TEGDMA and G (15.5%). In the group of patients the highest frequency of concomitant sensitization was to EGDMA and G (16.4%). The frequency of concomitant sensitization among dental professionals was much lower, with the highest rate to TEGDMA and G (7.7%), too. We consider the students from the dental technician school, where the exposure to glutaraldehyde is less likely, to be the group at a lesser risk of concomitant sensitization.
  
  
  CONCLUSIONS
  Dental students and dental patients could be outlined as groups at the risk of concomitant sensitization to glutaraldehyde and methacrylic monomers. For dental professionals, we assumed an increased risk for concomitant sensitization to TEGDMA and aldehydes that are commonly used in dentistry. We consider the students from the dental technician school to be the group at a lesser risk of concomitant sensitization to glutaraldehyde and methacrylic monomers. Med Pr 2016;67(3):311-320.
authors.affiliation: Medical University, Sofia, Bulgaria (Faculty of Medicine, Department of Hygiene, Medical Ecology and Nutrition). saly_grigory@abv.bg.
authors.forename: Maya Grigorievna
authors.initials: MG
authors.lastname: Lyapina
authors.affiliation: Medical University, Sofia, Bulgaria (Faculty of Dental Medicine, Department of Oral and Image Diagnostic).
authors.forename: Maria
authors.initials: M
authors.lastname: Dencheva
authors.affiliation: Medical University, Sofia, Bulgaria (Faculty of Dental Medicine, Department of Oral and Image Diagnostic).
authors.forename: Assya
authors.initials: A
authors.lastname: Krasteva-Panova
authors.affiliation: Medical University, Sofia, Bulgaria (Faculty of Dental Medicine, Department of Oral and Image Diagnostic).
authors.forename: Mariana
authors.initials: M
authors.lastname: Tzekova-Yaneva
authors.affiliation: Military Medical Academy, Sofia, Bulgaria (Legal Department).
authors.forename: Mariela
authors.initials: M
authors.lastname: Deliverska
authors.affiliation: Medical University, Sofia, Bulgaria (Faculty of Dental Medicine, Department of Oral and Image Diagnostic).
authors.forename: Angelina
authors.initials: A
authors.lastname: Kisselova-Yaneva
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003764:Dental Materials / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000209:etiology; D009783:Dermatitis, Occupational / Q000175:diagnosis* / Q000209:etiology; D005179:Faculty, Dental; D005260:Female; D005976:Glutaral / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008689:Methacrylates / Q000009:adverse effects*; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D010328:Patch Tests; D013335:Students, Dental; D055815:Young Adult
chemical_list: D003764:Dental Materials; D008689:Methacrylates; D005976:Glutaral
keywords: concomitant contact sensitization; dental professionals; glutaraldehyde; methacrylic monomers; students of dental medicine; students of dental technician school