title: Rotavirus vaccine strain transmission by vaccinated infants in the foster home.
abstract: Previous studies have demonstrated the transmission of rotavirus vaccine strains from vaccinated children to nonvaccinated siblings. We sought to fully elucidate the safety of rotavirus (RV) vaccination in closed contact circumstance, such as the foster home for future assessment of the vaccine safety in an neonatal intensive care unit. Stool samples were collected from 4 RV vaccinated (160 samples) and 23 unvaccinated (766 samples) infants. RV viral RNA loads were measured using real-time reverse transcription polymerase chain reaction (RT-PCR). RV vaccine strain RNA was persistently detected in stool samples collected from the four vaccine recipients and one unvaccinated infant, but not in the stool samples collected from the 22 other unvaccinated infants. The unvaccinated infant who tested positive for the RV vaccine strain was vaccinated prior to enrollment in this study. The quantitative real-time RT-PCR data revealed a peak viral RNA load 1 week after vaccination followed by a gradual decrease. The current study suggests that RV vaccination may be safe in a close contact environment because there was limited transmission from RV vaccinated to unvaccinated infants. J. Med. Virol. 89:79-84, 2017. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Miura
authors.affiliation: Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Japan.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Kawamura
authors.affiliation: Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Sugata
authors.affiliation: Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Japan.
authors.forename: Nozomi
authors.initials: N
authors.lastname: Koshiyama
authors.affiliation: Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Yoshikawa
authors.affiliation: Virology and Parasitology, Fujita Health University School of Medicine, Toyoake, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Komoto
authors.affiliation: Virology and Parasitology, Fujita Health University School of Medicine, Toyoake, Japan.
authors.forename: Koki
authors.initials: K
authors.lastname: Taniguchi
authors.affiliation: Faculty of Clinical Engineering, Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Ihira
authors.affiliation: Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Japan. tetsushi@fujita-hu.ac.jp.
authors.forename: Tetsushi
authors.initials: T
authors.lastname: Yoshikawa
mesh_terms: D003428:Cross Infection / Q000635:transmission* / Q000821:virology; D005243:Feces / Q000821:virology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011446:Prospective Studies; D012367:RNA, Viral / Q000032:analysis; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012401:Rotavirus / Q000145:classification* / Q000302:isolation & purification*; D012400:Rotavirus Infections / Q000635:transmission* / Q000821:virology; D022243:Rotavirus Vaccines / Q000008:administration & dosage*; D013997:Time Factors; D019562:Viral Load
chemical_list: D012367:RNA, Viral; D022243:Rotavirus Vaccines
keywords: horizontal transmission; human rotavirus; vaccine; viral excretion