title: [Expression of differentiated embryo-chondrocyte expressed gene l in oral squamous cell carcinoma and its clinical significance].
abstract: OBJECTIVE
  To investigate the expression of differentiated embryo-chondrocyte expressed gene l（DEC1）in oral squamous cell carcinoma（OSCC）and its clinical significance.
  
  
  METHODS
  Detection of the protein expression of DEC1 in tissue specimens from 80 primary OSCC patients and 30 cases of normal oral mucosa were performed using immunohistochemistry. SPSS10.0 software package was uses for statistical analysis.
  
  
  RESULTS
  The result of immunohistochemistry showed that positive expression rate of DEC1 in OSCC tissues was 92.50%, 5.00% in normal oral mucosa tissue. The difference was statistically significant (P<0.05). In OSCC tissues, the difference in expression of DEC1 was statistically significant (P<0.05) between highly differentiated group and lowly differentiated group, between patients with lymph node metastasis and patients without lymph node metastasis.
  
  
  CONCLUSIONS
  The significantly increased DEC1 gene may be associated with the tumorigenesis and development of OSCC.
authors.affiliation: Department of Stomatology, First People's Hospital of Changde. Changde 415003, Hunan Province, China. E-mail:youjingmin85@163.com.
authors.forename: Jing-min
authors.initials: JM
authors.lastname: You
authors.forename: Tong
authors.initials: T
authors.lastname: Su
authors.forename: Kun
authors.initials: K
authors.lastname: Xia
authors.affiliation: Department of Oral Pathology, Stomatology Hospital, Tianjin Medical University. Tianjin 300070,China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Liu
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism*; D002454:Cell Differentiation; D019902:Chondrocytes; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D009061:Mouth Mucosa / Q000378:metabolism; D009062:Mouth Neoplasms / Q000235:genetics / Q000378:metabolism*