title: Pre and postoperative evaluation of transcranial Doppler pulsatility index of the middle cerebral artery in patients with severe carotid artery stenosis.
abstract: In the management of severe carotid artery stenosis particular importance must be given to the evaluation of the risk of perioperative cerebral ischemic events. Our study analysed the possible relationship between the pre-operative middle cerebral artery Gosling Index, calculated after transcranial Doppler (TCD), and intra-operative stump pressure (SP), in order to identify patients with higher risk of ischemic accidents. Moreover, we studied pre- and post- operative Gosling Index values in association with possible events during follow-up. In a one-year time lapse 47 patients underwent either carotid endoarterectomy (CEA) or carotid artery stenting (CAS) with proximal embolic protection system. All patients were subject to pre- and post-operative TCD with calculation of the Gosling Index and intra-operative SP. We observed that higher pre-operative Gosling Index values are associated with lower intra-operative SP values, elements that represent a higher risk for cerebro-vascular ischemic accidents; this result is particularly evident when observing the diabetic sub-population. An increase in ischemic events did not present statistically significant differences when observing the populations treated with CEA or CAS. TCD and SP are valid and simple exams that can help identify precociously patients with a higher risk of cerebro-vascular accidents related to surgical or endovascular treatment.
  
  
  BACKGROUND
  Carotid artery stenosis, Carotid endarterectomy, Endovascular treatment.
authors.forename: Umberto Marcello
authors.initials: UM
authors.lastname: Bracale
authors.forename: Flavia
authors.initials: F
authors.lastname: Spalla
authors.forename: Federica
authors.initials: F
authors.lastname: Caioni
authors.forename: Domenico
authors.initials: D
authors.lastname: Solari
authors.forename: Donatella
authors.initials: D
authors.lastname: Narese
authors.forename: Felice
authors.initials: F
authors.lastname: Pecoraro
authors.forename: Luca
authors.initials: L
authors.lastname: Del Guercio
mesh_terms: D016893:Carotid Stenosis / Q000188:drug therapy* / Q000503:physiopathology*; D016894:Endarterectomy, Carotid; D005260:Female; D006801:Humans; D008297:Male; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D011182:Postoperative Care; D011300:Preoperative Care; D011446:Prospective Studies; D011673:Pulsatile Flow; D012720:Severity of Illness Index; D017585:Ultrasonography, Doppler, Transcranial