title: Glucose tolerance status of Asian Indian women with gestational diabetes at 6weeks to 1year postpartum (WINGS-7).
abstract: OBJECTIVE
  To determine postpartum glucose tolerance status among women with gestational diabetes mellitus (GDM) recruited under the Women In India with GDM Strategy (WINGS) Model of Care (MOC).
  
  
  METHODS
  Through the WINGS MOC programme, 212 women with GDM were followed till delivery between November 2013 and August 2015. All women were advised to return for a postpartum oral glucose tolerance test (OGTT) 6-12weeks after delivery. A multivariate logistic regression (MLR) model was developed to identify the risk factors for postpartum dysglycemia which was defined as presence of diabetes (DM) or prediabetes.
  
  
  RESULTS
  203/212(95.8%) women completed their postpartum OGTT. Of the 161 women (79.3%) who came back for the test between 6 and 12weeks, 2(1.2%) developed DM, 5(3.1%), isolated IFG, 13(8.1%), isolated IGT and 5(3.1%) combined IFG/IGT [dysglycemia 25(15.5%)]. 136 women (84.5%) reverted to normal glucose tolerance (NGT). Of the 42 women who came back between 12weeks and a year, 5(11.9%) developed DM, 10(23.8%), isolated IFG and 1(2.4%) combined IFG/IGT [dysglycemia 16(38.1%)]. 26/42 women (61.9%) reverted to NGT. Thus overall dysglycemia occurred in 41/203 women (20.2%). MLR showed that BMI ⩾25kg/m(2) was significantly associated with postpartum dysglycemia (odds ratio: 4.47; 95% confidence interval: 1.8-11.2, p=0.001).
  
  
  CONCLUSIONS
  Among Asian Indian women with GDM, over 20% develop dysglycemia within one year postpartum, and BMI ⩾25kg/m(2) increased this risk four-fold. Early postpartum screening can identify high risk women and help plan strategies for prevention of type 2 diabetes in the future.
authors.affiliation: Madras Diabetes Research Foundation, Chennai, India.
authors.forename: Balaji
authors.initials: B
authors.lastname: Bhavadharini
authors.affiliation: Madras Diabetes Research Foundation, Chennai, India.
authors.forename: Ranjit Mohan
authors.initials: RM
authors.lastname: Anjana
authors.affiliation: Madras Diabetes Research Foundation, Chennai, India.
authors.forename: Manni Mohanraj
authors.initials: MM
authors.lastname: Mahalakshmi
authors.affiliation: Madras Diabetes Research Foundation, Chennai, India.
authors.forename: Kumar
authors.initials: K
authors.lastname: Maheswari
authors.affiliation: International Diabetes Federation, Brussels, Belgium.
authors.forename: Arivudainambi
authors.initials: A
authors.lastname: Kayal
authors.affiliation: Madras Diabetes Research Foundation, Chennai, India.
authors.forename: Ranjit
authors.initials: R
authors.lastname: Unnikrishnan
authors.affiliation: Madras Diabetes Research Foundation, Chennai, India.
authors.forename: Harish
authors.initials: H
authors.lastname: Ranjani
authors.affiliation: International Diabetes Federation, Brussels, Belgium.
authors.forename: Lyudmil
authors.initials: L
authors.lastname: Ninov
authors.affiliation: Purdue University, College of Pharmacy, West Lafayette, IN, USA.
authors.forename: Sonak D
authors.initials: SD
authors.lastname: Pastakia
authors.affiliation: Associates in Clinical Endocrinology Education and Research (ACEER), Chennai, India.
authors.forename: Sriram
authors.initials: S
authors.lastname: Usha
authors.affiliation: International Diabetes Federation, Brussels, Belgium.
authors.forename: Belma
authors.initials: B
authors.lastname: Malanda
authors.affiliation: International Diabetes Federation, Brussels, Belgium.
authors.forename: Anne
authors.initials: A
authors.lastname: Belton
authors.affiliation: Seethapathy Clinic and Hospital, Chennai, India.
authors.forename: Ram
authors.initials: R
authors.lastname: Uma
authors.affiliation: Madras Diabetes Research Foundation, Chennai, India. Electronic address: drmohans@diabetes.ind.in.
authors.forename: Viswanathan
authors.initials: V
authors.lastname: Mohan
mesh_terms: D000328:Adult; D044466:Asian People; D001786:Blood Glucose / Q000032:analysis; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000175:diagnosis; D016640:Diabetes, Gestational / Q000503:physiopathology*; D005260:Female; D018149:Glucose Intolerance / Q000453:epidemiology*; D005951:Glucose Tolerance Test; D006801:Humans; D007194:India / Q000453:epidemiology; D049590:Postpartum Period; D011236:Prediabetic State / Q000150:complications* / Q000175:diagnosis; D011247:Pregnancy; D012307:Risk Factors
chemical_list: D001786:Blood Glucose
keywords: Asian Indians; Dysglycemia; Gestational diabetes mellitus; IADPSG; Post partum follow-up; South Asians