title: The guiding significance of NT-proBNP and PCT levels in mechanical ventilator of patients with chronic respiratory failure.
abstract: To analyze the guiding significance of N-terminal pro-brain natriuretic peptide (NT-proBNP) and procalcitonin (PCT) level in mechanical ventilator used for patients with chronic respiratory failure.
  
  
  
  Eighty-two patients with simple chronic respiratory failure who were treated by mechanical ventilator were selected for this study. They were treated offline after they reached the standards of spontaneous breathing trial, and were divided into two groups: 1- the successful offline group with 59 patients and 2- the failure group with 23 patients. Differences of NT-proBNP and PCT levels, oxygenation index, average heart rate and mean arterial pressure between two groups were compared.
  
  
  
  The NT-proBNP and PCT levels in the failure group were significantly higher than those in the success group, while oxygenation index was significantly lower in the success group. All differences were statistically significant (p<0.05). Comparison of average heart rate and mean arterial pressure between two groups showed no statistically significant difference (p>0.05).
  
  
  
  Through multi-factor regression analyses we observed that NT-proBNP and PCT levels were independent risk factors for guiding the success rate of offline (p<0.05). Spontaneous breathing trial in combination with NT-proBNP and PCT levels improved the success rate of offline.
authors.affiliation: Intensive Care Unit, Department of Respiratory Medicine, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Xinxiang, Henan, P. R. China.hou_chenyan1@163.com.
authors.forename: Y-T
authors.initials: YT
authors.lastname: Wang
authors.forename: J-J
authors.initials: JJ
authors.lastname: Fu
authors.forename: Y-R
authors.initials: YR
authors.lastname: Li
authors.forename: S-Z
authors.initials: SZ
authors.lastname: Zang
authors.forename: Y-R
authors.initials: YR
authors.lastname: Yang
authors.forename: C-Y
authors.initials: CY
authors.lastname: Zhou
authors.forename: C-F
authors.initials: CF
authors.lastname: Li
mesh_terms: D015415:Biomarkers; D002116:Calcitonin; D006333:Heart Failure; D006801:Humans; D020097:Natriuretic Peptide, Brain; D010446:Peptide Fragments; D012131:Respiratory Insufficiency
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D002116:Calcitonin