title: Prognostic Significance of NOGO-A/B and NOGO-B Receptor Expression in Malignant Melanoma - A Preliminary Study.
abstract: BACKGROUND
  Neurite outgrowth inhibitor type B (NOGO-B) and its receptor (NGBR) were shown to regulate various crucial cellular processes and may be therefore potential factors influencing carcinogenesis.
  
  
  METHODS
  Expression of NOGO-A, NOGO-A/B and NGBR was studied in benign melanocytic lesions and primary tumors and metastases of malignant melanoma (MM).
  
  
  RESULTS
  Cytoplasmic expression of the studied antigens was detected in melanocytes and MM cells. NOGO-A/B expression was significantly lower in metastatatic MM cases compared to primary MM tumors (p<0.01) and bening melanocytic lesions (p<0.001). In primary MM tumors, NOGO-A expression intensity positively correlated with NOGO-A/B (r=0.32, p<0.05) and NGBR expression (r=0.53, p<0.0001). NOGO-B and NGBR immunoreactivity correlated negatively with depth of primary MM infiltration (both p<0.01). Moreover, low NOGO-A/B expression was a factor of poor prognosis of primary MM.
  
  
  CONCLUSIONS
  NOGO-A/B may be a negative prognostic factor of MM.
authors.affiliation: Department of Chemotherapy, Lower Silesian Oncology Center, Wroclaw, Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Calik
authors.affiliation: Department of Histology and Embryology, Medical University, Wroclaw, Poland Research and Development Center, Regional Specialist Hospital, Wroclaw, Poland.
authors.forename: Bartosz
authors.initials: B
authors.lastname: Pula
authors.affiliation: Department of Histology and Embryology, Medical University, Wroclaw, Poland Research and Development Center, Regional Specialist Hospital, Wroclaw, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Piotrowska
authors.affiliation: Department of Pathology, Lower Silesian Oncology Center, Wroclaw, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Wojnar
authors.affiliation: Research and Development Center, Regional Specialist Hospital, Wroclaw, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Witkiewicz
authors.affiliation: Department of Histology and Embryology, Medical University, Wroclaw, Poland.
authors.forename: Jedrzej
authors.initials: J
authors.lastname: Grzegrzolka
authors.affiliation: Department of Histology and Embryology, Medical University, Wroclaw, Poland Research and Development Center, Regional Specialist Hospital, Wroclaw, Poland.
authors.forename: Marzena
authors.initials: M
authors.lastname: Podhorska-Okolow
authors.affiliation: Department of Histology and Embryology, Medical University, Wroclaw, Poland Research and Development Center, Regional Specialist Hospital, Wroclaw, Poland Department of Physiotherapy, University School of Physical Education, Wroclaw, Poland piotr.dziegiel@umed.wroc.pl.
authors.forename: Piotr
authors.initials: P
authors.lastname: Dziegiel
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008545:Melanoma / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D008875:Middle Aged; D000070798:Nogo Proteins / Q000378:metabolism*; D011379:Prognosis; D012878:Skin Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; D000070798:Nogo Proteins; C000603199:RTN4 protein, human
keywords: Malignant melanoma; NOGO-A/B; NOGO-B receptor; immunohistochemistry