title: Generation of a transgenic mouse line for conditional expression of human IL-6.
abstract: IL-6 is a cytokine that is involved in various physiological and pathological conditions, and approaches using gain-of-function transgenic animals have contributed in elucidating IL-6 function. However, studies of the multiple functions of IL-6 in vivo are very time consuming because they require the generation of transgenic mice that harbor the gene encoding IL-6 under the control of specific promoters to mimic different pathologies. Here, we report the establishment of a conditional human IL-6 transgenic mouse, LGL-IL6, which conditionally expresses human IL-6 by taking advantage of the well-characterized Cre recombinase drivers.
authors.affiliation: Medical Genome Center, National Center for Geriatrics and Gerontology (NCGG), Obu, Aichi 474-8511, Japan.
authors.forename: Taiki
authors.initials: T
authors.lastname: Mori
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Murasawa
authors.forename: Rina
authors.initials: R
authors.lastname: Ikai
authors.forename: Tomoko
authors.initials: T
authors.lastname: Hayakawa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakamura
authors.forename: Noboru
authors.initials: N
authors.lastname: Ogiso
authors.forename: Shumpei
authors.initials: S
authors.lastname: Niida
authors.forename: Ken
authors.initials: K
authors.lastname: Watanabe
mesh_terms: D000818:Animals; D015870:Gene Expression; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics* / Q000378:metabolism; D008822:Mice, Transgenic / Q000235:genetics* / Q000378:metabolism
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6