title: (-)-SCR1693 Protects against Memory Impairment and Hippocampal Damage in a Chronic Cerebral Hypoperfusion Rat Model.
abstract: Chronic cerebral hypoperfusion (CCH) is one of the most common causes of vascular dementia (VaD) and is recognised as an etiological factor in the development of Alzheimer's disease (AD). CCH can induce severe cognitive deficits, as assessed by the water maze task, along with neuronal loss in the hippocampus. However, there are currently no effective, approved pharmacological treatments available for VaD. In the present study, we created a rat model of CCH using bilateral common carotid artery occlusion and found that (-)-SCR1693, a novel compound, prevented rats from developing memory deficits and neuronal damage in the hippocampus by rectifying cholinergic dysfunction and decreasing the accumulation of the phospho-tau protein. These results strongly suggest that (-)-SCR1693 has therapeutic potential for the treatment of CCH-induced VaD.
authors.affiliation: Department of Pharmacology, Shandong Univeristy School of Medicine 44#, Wenhua Xi Road, Jinan, Shandong, 250012 P.R. China.|School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai 264005, P.R. China.
authors.forename: Xiaoyin
authors.initials: X
authors.lastname: Zhu
authors.affiliation: School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai 264005, P.R. China.
authors.forename: Jingwei
authors.initials: J
authors.lastname: Tian
authors.affiliation: School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai 264005, P.R. China.
authors.forename: Songmei
authors.initials: S
authors.lastname: Sun
authors.affiliation: School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai 264005, P.R. China.
authors.forename: Qiuju
authors.initials: Q
authors.lastname: Dong
authors.affiliation: School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai 264005, P.R. China.
authors.forename: Fangxi
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Department of Pharmacology, Shandong Univeristy School of Medicine 44#, Wenhua Xi Road, Jinan, Shandong, 250012 P.R. China.
authors.forename: Xiumei
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001157:Arterial Occlusive Diseases / Q000378:metabolism / Q000503:physiopathology; D002340:Carotid Artery Diseases / Q000378:metabolism / Q000503:physiopathology; D002561:Cerebrovascular Disorders / Q000378:metabolism / Q000503:physiopathology*; D002908:Chronic Disease; D015140:Dementia, Vascular / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D009474:Neurons / Q000378:metabolism; D020011:Protective Agents / Q000494:pharmacology; D017207:Rats, Sprague-Dawley; D013619:Tacrine / Q000031:analogs & derivatives* / Q000494:pharmacology; D016875:tau Proteins / Q000378:metabolism
chemical_list: D020011:Protective Agents; C000600497:SCR1693; D016875:tau Proteins; D013619:Tacrine