title: Tenofovir pharmacokinetic after sleeve-gastrectomy in four severely obese patients living with HIV.
abstract: There are many unsolved questions about safety of bariatric surgery in the context of severely obese patients living with human immunodeficiency virus (HIV) and notably on antiretroviral therapy (ART) absorption. Here, we provide the first case series of tenofovir disoproxil fumarate (TDF) pharmacokinetic in four HIV-infected patients before and after sleeve-gastrectomy. Our case-series showed a transient and reversible decrease of TDF bioavailability one month after sleeve-gastrectomy without any consequences on CD4 cells and HIV viral load. More studies are needed since the impact of bariatric surgery on drug absorptions in the field of infectious diseases remains poorly investigated.
authors.affiliation: Department of Nutrition, Ambroise Pare Hospital (AP-HP), University of Versailles Saint Quentin en Yvelines, 9 avenue Charles-de-Gaulle, 92100 Boulogne-Billancourt, France. Electronic address: lmuzard@pavillon-mutualite.fr.
authors.forename: Ludivine
authors.initials: L
authors.lastname: Muzard
authors.affiliation: Department of Pharmacology-Toxicology, Raymond Poincare Hospital (AP-HP), INSERM U1173, University of Versailles Saint Quentin en Yvelines, 92380 Garches, France. Electronic address: jean-claude.alvarez@aphp.fr.
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Alvarez
authors.affiliation: Department of Nutrition, Ambroise Pare Hospital (AP-HP), University of Versailles Saint Quentin en Yvelines, 9 avenue Charles-de-Gaulle, 92100 Boulogne-Billancourt, France. Electronic address: christophe.gbedo@gmail.com.
authors.forename: Christophe
authors.initials: C
authors.lastname: Gbedo
authors.affiliation: Department of Nutrition, Ambroise Pare Hospital (AP-HP), University of Versailles Saint Quentin en Yvelines, 9 avenue Charles-de-Gaulle, 92100 Boulogne-Billancourt, France; Inserm, Population-based Epidemiologic Cohorts Unit, UMS 011, 94800 Villejuif, France. Electronic address: sebastien.czernichow@aphp.fr.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Czernichow
authors.affiliation: Department of Nutrition, Ambroise Pare Hospital (AP-HP), University of Versailles Saint Quentin en Yvelines, 9 avenue Charles-de-Gaulle, 92100 Boulogne-Billancourt, France. Electronic address: claire.carette@aphp.fr.
authors.forename: Claire
authors.initials: C
authors.lastname: Carette
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000493:pharmacokinetics*; D050110:Bariatric Surgery / Q000009:adverse effects* / Q000379:methods; D001682:Biological Availability; D018791:CD4 Lymphocyte Count; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects*; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000150:complications / Q000601:surgery; D011183:Postoperative Complications; D000068698:Tenofovir / Q000493:pharmacokinetics*; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents; D000068698:Tenofovir
keywords: Bariatric surgery; HIV; Obesity; Pharmacokinetic; Tenofovir