title: Eruptive Facial Postinflammatory Lentigo: Clinical and Dermatoscopic Features.
abstract: The face has not been considered a common site of fixed drug eruption, and the authors lack dermatoscopic studies of this condition on the subject. The authors sought to characterize clinical and dermatoscopic features of 8 cases of an eruptive facial postinflammatory lentigo. The authors conducted a retrospective review of 8 cases with similar clinical and dermatoscopic findings seen from 2 medical centers in 2 countries during 2010-2014. A total of 8 patients (2 males and 6 females) with ages that ranged from 34 to 62 years (mean: 48) presented an abrupt onset of a single facial brown-pink macule, generally asymmetrical, with an average size of 1.9 cm. after ingestion of a nonsteroidal antiinflammatory drugs that lasted for several months. Dermatoscopy mainly showed a pseudonetwork or uniform areas of brown pigmentation, brown or blue-gray dots, red dots and/or telangiectatic vessels. In the epidermis, histopathology showed a mild hydropic degeneration and focal melanin hyperpigmentation. Melanin can be found freely in the dermis or laden in macrophages along with a mild perivascular mononuclear infiltrate. The authors describe eruptive facial postinflammatory lentigo as a new variant of a fixed drug eruption on the face.
authors.affiliation: *Department of Dermatology, Clínica Alemana de Santiago, Chile; †Melanoma Unit, Department of Dermatology, Hospital Clinic of Barcelona, Barcelona, Spain; ‡Department of Pathology, Clínica Alemana de Santiago, Chile; §Department of Medicine, Hospital de Carabineros de Chile, Chile; and ¶Department of Dermatology, Universidad del Desarrollo, Chile.
authors.forename: Raul
authors.initials: R
authors.lastname: Cabrera
authors.forename: Susana
authors.initials: S
authors.lastname: Puig
authors.forename: Jorge
authors.initials: J
authors.lastname: Larrondo
authors.forename: Alex
authors.initials: A
authors.lastname: Castro
authors.forename: Karen
authors.initials: K
authors.lastname: Valenzuela
authors.forename: Natalia
authors.initials: N
authors.lastname: Sabatini
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D002677:Chile; D046169:Dermoscopy; D003875:Drug Eruptions / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D005148:Facial Dermatoses / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D017495:Hyperpigmentation / Q000139:chemically induced / Q000473:pathology; D007911:Lentigo / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008543:Melanins / Q000032:analysis; D008875:Middle Aged; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors; D012867:Skin / Q000737:chemistry / Q000187:drug effects / Q000473:pathology*; D013030:Spain
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D015415:Biomarkers; D008543:Melanins