title: Comprehensive meta-analytical summary on human papillomavirus association with head and neck cancer.
abstract: An etiological role of high risk human papillomavirus (HPV) in the development of cervical cancer has been well established. Hence, attention of researchers has been focused on the role of HPV in pathogenesis of other malignancies, such as head and neck cancers. An analysis of epidemiological data on the prevalence of HPV infection among healthy people and patients with precancerous lesions and/or cancer is an important step in understanding the role of HPV in head and neck carcinogenesis. More and more data de-monstrate the impact of HPV infection on disease outcome. HPV-positive patients have been shown to have better responses to radiotherapy and better overall and disease-free survival than HPV-negative patients. This review presents data of the meta-analysis based on a large number of original studies on HPV prevalence in patients with precancerous lesions and in patients with oral, oropharyngeal and laryngeal cancers as well as findings on the impact of HPV infection on survival of these patients.
authors.affiliation: Tomsk Cancer Research Institute, Tomsk 634050, Russian Federation.
authors.forename: V A
authors.initials: VA
authors.lastname: Bychkov
authors.affiliation: Tomsk Cancer Research Institute, Tomsk 634050, Russian Federation.
authors.forename: E G
authors.initials: EG
authors.lastname: Nikitina
authors.affiliation: Tomsk Cancer Research Institute, Tomsk 634050, Russian Federation.
authors.forename: M K
authors.initials: MK
authors.lastname: Ibragimova
authors.affiliation: Tomsk Cancer Research Institute, Tomsk 634050, Russian Federation.
authors.forename: E V
authors.initials: EV
authors.lastname: Kaigorodova
authors.affiliation: Siberian State Medical University, Tomsk 634050, Russian Federation.
authors.forename: E L
authors.initials: EL
authors.lastname: Choinzonov
authors.affiliation: National Research Tomsk State University, Tomsk 634050, Russian Federation.
authors.forename: N V
authors.initials: NV
authors.lastname: Litviakov
mesh_terms: D006258:Head and Neck Neoplasms / Q000453:epidemiology / Q000821:virology*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000453:epidemiology / Q000821:virology*; D009062:Mouth Neoplasms / Q000453:epidemiology / Q000821:virology*; D009959:Oropharyngeal Neoplasms / Q000453:epidemiology / Q000821:virology*; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000150:complications* / Q000821:virology; D015995:Prevalence; D016019:Survival Analysis