title: Ovulation Induction is a More Effective Stimulant on Antiovarian Antibody Production than In Vitro Fertilization.
abstract: Our aim in this study is to evaluate the effects of in vitro fertilization (IVF), including controlled ovarian hyperstimulation (COH) and the number of oocyte pick-up (OPU) procedures on the development of anti-ovarian antibodies (AOA).
  
  
  
  To evaluate the effects of IVF procedures, namely, COH and OPU, serum samples for measuring AOA concentration levels by enzyme-linked immunosorbent assay were collected on the third day of the menstrual cycle, at the end of the COH, and after OPU.
  
  
  
  The AOA levels in IVF patients were significantly higher than the fertile control groups'. In the IVF group, neither COH nor OPU caused any increase in AOA levels when compared to the basal results. AOA levels were higher in patients with a history of 5-8 cycles of ovulation induction, before IVF treatment. There was no relationship between the basal AOA concentrations and the type of infertility, the etiology of infertility or the pregnancy outcomes, whereas there was a relationship between the AOA and the duration of infertility.
  
  
  
  AOA levels of IVF patients were found to be higher than the fertile control groups'. AOA was found to be related to infertility in patients who had a longer duration of infertility and repeated ovulation induction procedures without IVF. COH and OPU during an IVF cycle did not cause an increase in AOA levels.
authors.affiliation: Department of Obstetrics and Gynecology, Şereflikoçhisar Government Hospital, Ankara, Turkey.
authors.forename: Nezaket
authors.initials: N
authors.lastname: Kadıoğlu
authors.affiliation: Department of Obstetrics and Gynecology, Liv Hospital, Ankara, Turkey. basakgumusbg@yahoo.com.
authors.forename: Başak
authors.initials: B
authors.lastname: Güler
authors.affiliation: Department of Obstetrics and Gynecology, Dr. Zekai Tahir Burak Women's Health And Research Hospital, Ankara, Turkey.
authors.forename: Sibel
authors.initials: S
authors.lastname: Özler
authors.affiliation: Department of Obstetrics and Gynecology, Bahçeşehir University, İstanbul, Turkey.
authors.forename: Sevtap
authors.initials: S
authors.lastname: Kılıç
authors.affiliation: Department of Obstetrics and Gynecology, Dr. Zekai Tahir Burak Women's Health And Research Hospital, Ankara, Turkey.
authors.forename: M Nedim
authors.initials: MN
authors.lastname: Çiçek
authors.affiliation: Department of Obstetrics and Gynecology, Kolan Hospital, İstanbul, Turkey.
authors.forename: A Sertaç
authors.initials: AS
authors.lastname: Batıoğlu
mesh_terms: D000328:Adult; D000917:Antibody Formation / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D054315:Oocyte Retrieval; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy
chemical_list: D001323:Autoantibodies
keywords: Antiovarian antibodies; In vitro fertilization; Infertility; Ooocyte pick-up; Ovulation induction; Reproduction