title: Cupreines and cupreidines: an established class of bifunctional cinchona organocatalysts.
abstract: Cinchona alkaloids with a free 6'-OH functionality are being increasingly used within asymmetric organocatalysis. This fascinating class of bifunctional catalyst offers a genuine alternative to the more commonly used thiourea systems and because of the different spacing between the functional groups, can control enantioselectivity where other organocatalysts have failed. In the main, this review covers the highlights from the last five years and attempts to show the diversity of reactions that these systems can control. It is hoped that chemists developing asymmetric methodologies will see the value in adding these easily accessible, but underused organocatalysts to their screens.
authors.affiliation: School of Chemistry, Food and Pharmacy (SCFP), University of Reading, Whiteknights, Reading, Berks RG6 6AD, United Kingdom.
authors.forename: Laura A
authors.initials: LA
authors.lastname: Bryant
authors.affiliation: School of Chemistry, Food and Pharmacy (SCFP), University of Reading, Whiteknights, Reading, Berks RG6 6AD, United Kingdom.
authors.forename: Rossana
authors.initials: R
authors.lastname: Fanelli
authors.affiliation: School of Chemistry, Food and Pharmacy (SCFP), University of Reading, Whiteknights, Reading, Berks RG6 6AD, United Kingdom.
authors.forename: Alexander J A
authors.initials: AJ
authors.lastname: Cobb
keywords: bifunctional; cinchona; cupreidine; cupreine; organocatalysis