title: Donor oocytes are associated with preterm birth when compared to fresh autologous in vitro fertilization cycles in singleton pregnancies.
abstract: OBJECTIVE
  To use a national registry to examine the role of oocyte donation on pregnancy outcomes in singleton pregnancies.
  
  
  METHODS
  Retrospective cohort.
  
  
  METHODS
  Not applicable.
  
  
  METHODS
  Women undergoing autologous cycles and donor oocyte recipients in the United States from 2008-2010.
  
  
  METHODS
  None.
  
  
  METHODS
  Preterm delivery, birth weight <2,500 g, small for gestational age birthweight, perinatal death.
  
  
  RESULTS
  The rates of preterm delivery and low birthweight for all members of this cohort were higher than the US national average. Pregnancies resulting from oocyte donation were significantly more likely to end before 34 weeks' and 37 weeks' gestation (adjusted odds ratio [OR] = 1.30, 95% confidence interval [CI] = 1.03-1.64 for 34 weeks' gestation, adjusted OR = 1.28, 95% CI = 1.12-1.46 for 37 weeks' gestation), and to result in infants weighing <2,500 g (adjusted OR = 1.21, 95% CI = 1.02-1.44). However, once gestational age at delivery is accounted for, these infants are actually at decreased risk of having a small for gestational age birthweight (adjusted OR = 0.72, 95% CI = 0.58-0.89) and of perinatal death (adjusted OR = 0.29, 95% CI = 0.09-0.94).
  
  
  CONCLUSIONS
  Data from a national cohort indicate that donor oocyte recipients are more likely to deliver preterm when compared with autologous patients. The effect of donor oocyte donation on birthweight is likely a function of an increased rate of preterm delivery among this population.
authors.affiliation: Department of Obstetrics and Gynecology, University of Illinois at Chicago, Chicago, Illinois. Electronic address: annie.dude@gmail.com.
authors.forename: Annie M
authors.initials: AM
authors.lastname: Dude
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Duke University Medical Center, Durham, North Carolina.
authors.forename: Jason S
authors.initials: JS
authors.lastname: Yeh
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Duke University Medical Center, Durham, North Carolina.
authors.forename: Suheil J
authors.initials: SJ
authors.lastname: Muasher
mesh_terms: D000328:Adult; D001724:Birth Weight; D016009:Chi-Square Distribution; D005260:Female; D005298:Fertility; D005307:Fertilization in Vitro / Q000009:adverse effects* / Q000401:mortality; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D007246:Infertility / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D016015:Logistic Models; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D018587:Oocyte Donation / Q000009:adverse effects* / Q000401:mortality; D066087:Perinatal Death; D011247:Pregnancy; D047928:Premature Birth / Q000209:etiology* / Q000401:mortality; D012042:Registries; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D016896:Treatment Outcome; D014481:United States
keywords: Donor oocytes; low birth weight; perinatal death; preterm birth