title: Transcriptome sequencing of neurologic diseases associated genes in HHV-6A infected human astrocyte.
abstract: Human Herpesvirus 6 (HHV-6) has been involved in the development of several central nervous system (CNS) diseases, such as Alzheimer's disease, multiple sclerosis and glioma. In order to identify the pathogenic mechanism of HHV-6A infection, we carried out mRNA-seq study of human astrocyte HA1800 cell with HHV-6A GS infection. Using mRNA-seq analysis of HA1800-control cells with HA1800-HHV-6A GS cells, we identified 249 differentially expressed genes. After investigating these candidate genes, we found seven genes associated with two or more CNS diseases: CTSS, PTX3, CHI3L1, Mx1, CXCL16, BIRC3, and BST2. This is the first transcriptome sequencing study which showed the significant association of these genes between HHV-6A infection and neurologic diseases. We believe that our findings can provide a new perspective to understand the pathogenic mechanism of HHV-6A infection and neurologic diseases.
authors.affiliation: Department of Immunology, Nanjing Medical University, Nanjing, Jiangsu Province, People's Republic of China.|Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, People's Republic of China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Shao
authors.affiliation: Department of Immunology, Nanjing Medical University, Nanjing, Jiangsu Province, People's Republic of China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Lin
authors.affiliation: Genetic Data Analysis Group, Shanghai Biotechnology Corporation, Shanghai, People's Republic of China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Wu
authors.affiliation: Liver Transplantation Center of The First Affiliated Hospital and Collaborative Innovation Center For Cancer Personalized Medicine, Nanjing Medical University, Nanjing, Jiangsu Province, People's Republic of China.
authors.forename: Junwei
authors.initials: J
authors.lastname: Tang
authors.affiliation: Department of Immunology, Nanjing Medical University, Nanjing, Jiangsu Province, People's Republic of China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Lu
authors.affiliation: Department of Immunology, Nanjing Medical University, Nanjing, Jiangsu Province, People's Republic of China.
authors.forename: Dongju
authors.initials: D
authors.lastname: Feng
authors.affiliation: Department of Immunology, Nanjing Medical University, Nanjing, Jiangsu Province, People's Republic of China.
authors.forename: Ci
authors.initials: C
authors.lastname: Cheng
authors.affiliation: Department of Immunology, Nanjing Medical University, Nanjing, Jiangsu Province, People's Republic of China.
authors.forename: Lanqun
authors.initials: L
authors.lastname: Qing
authors.affiliation: Department of Immunology, Nanjing Medical University, Nanjing, Jiangsu Province, People's Republic of China.
authors.forename: Kun
authors.initials: K
authors.lastname: Yao
authors.affiliation: Department of Immunology, Nanjing Medical University, Nanjing, Jiangsu Province, People's Republic of China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Chen
mesh_terms: D001253:Astrocytes / Q000502:physiology* / Q000821:virology*; D018929:Cell Culture Techniques; D015654:Herpesvirus 6, Human / Q000502:physiology*; D006801:Humans; D009422:Nervous System Diseases / Q000235:genetics* / Q000473:pathology / Q000821:virology*; D019349:Roseolovirus Infections / Q000235:genetics*; D059467:Transcriptome
keywords: HHV-6; astrocyte; neurologic diseases; transcriptome sequencing study