title: Correlation of Early and Late Ejection Fractions with CCL5 and CCL18 Levels in Acute Anterior Myocardial Infarction.
abstract: BACKGROUND
  Acute Myocardial Infarction (AMI) is the leading cause of disability and death in Iran and many other countries.
  
  
  OBJECTIVE
  To investigate the prognostic value of CCL5 and CCL18 in patients with acute myocardial ischemia.
  
  
  METHODS
  In this cohort study we recruited and followed 50 patients with acute anterior myocardial infarction (AAMI) for developing cardiovascular accidents in a 6-month period. CCL5 and CCL18 levels were measured on admission, at day 5 and at day 180 post-hospitalization.
  
  
  RESULTS
  CCL18 and CCL5 levels at day 180 were higher in patients with late (day 180) and early (day 5) LVEF less than 35% compared to those with higher LVEF (p=0.05 and p=0.042, respectively). There was a negative correlation between early and late LVEF and regional wall motion abnormalities (p=0.001 and p=0.002, respectively). There was also a trend of negative correlation between CCL18 levels at day 5 and LVEF levels at day 180 post-hospitalization (p=0.06).
  
  
  CONCLUSIONS
  CCL18 has a correlation with cardiac function in patients with AAMI and it might be considered as an indicator of poor LVEF in patients with AAMI.
authors.affiliation: Department of Cardiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mahdi
authors.initials: M
authors.lastname: Sajedi Khanian
authors.forename: Alireza
authors.initials: A
authors.lastname: Abdi Ardekani
authors.forename: Shahdad
authors.initials: S
authors.lastname: Khosropanah
authors.forename: Mehrnoosh
authors.initials: M
authors.lastname: Doroudchi
mesh_terms: D000328:Adult; D000368:Aged; D056988:Anterior Wall Myocardial Infarction / Q000175:diagnosis*; D018946:Chemokine CCL5 / Q000097:blood*; D019742:Chemokines, CC / Q000097:blood*; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D013318:Stroke Volume
chemical_list: C111792:CCL18 protein, human; C483024:CCL5 protein, human; D018946:Chemokine CCL5; D019742:Chemokines, CC