title: Prognostic Factors and Treatment Outcome for Patients with Stage IVB Cervical Cancer.
abstract: OBJECTIVE
  We report a retrospective evaluation for patients with stage IVB cervical cancer in order to identify survival rates and to improve our current practice.
  
  
  METHODS
  We analyzed 85 patients with stage IVB cervical cancer. For patients appropriate for radical treatment, a combination of external-beam radiotherapy and intracavitary brachytherapy was delivered with/without chemotherapy. Patients with distant metastasis were treated using systemic chemotherapy or palliative radiotherapy.
  
  
  RESULTS
  Forty-two patients were treated using radiotherapy alone, 31 using chemotherapy followed by radiotherapy, eight using chemotherapy alone, and four using best supportive care. The 5-year overall survival rate was 9.9%. Multivariate analysis revealed leukocytosis and a poor performance status were independent prognostic factors. Of the 43 patients without these prognostic factors, patients with only lymph node metastasis had a 5-year overall survival rate of 40.5%.
  
  
  CONCLUSIONS
  Radical treatment should be considered in patients who have only lymph rode metastasis and are without leukocytosis and a poor performance status.
authors.affiliation: Department of Obstetrics and Gynecology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
authors.forename: Sugiko
authors.initials: S
authors.lastname: Oishi
authors.affiliation: Department of Obstetrics and Gynecology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
authors.forename: Wataru
authors.initials: W
authors.lastname: Kudaka
authors.affiliation: Department of Radiology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Toita
authors.affiliation: Department of Radiology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
authors.forename: Takuro
authors.initials: T
authors.lastname: Ariga
authors.affiliation: Department of Obstetrics and Gynecology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Nakamoto
authors.affiliation: Department of Obstetrics and Gynecology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Wakayama
authors.affiliation: Department of Obstetrics and Gynecology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Nagai
authors.affiliation: Department of Obstetrics and Gynecology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
authors.forename: Itomi
authors.initials: I
authors.lastname: Kaneshima
authors.affiliation: Department of Obstetrics and Gynecology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
authors.forename: Kumiko
authors.initials: K
authors.lastname: Nishihira
authors.affiliation: Department of Obstetrics and Gynecology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan yoichi@med.u-ryukyu.ac.jp.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Aoki
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000556:secondary* / Q000628:therapy; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000401:mortality / Q000556:secondary* / Q000628:therapy; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy
keywords: Cervical cancer; PS; leukocytosis; prognostic factor; stage IVB