title: The influence of thiamin on the efficacy of pregabalin in rats with spinal nerve ligation (SNL)-induced neuropathic pain.
abstract: OBJECTIVE
  The thiamin is often used in the treatment of neuropathy, and pregabalin is often used to treat neuropathic pain. Our study examined the influence of thiamin on the efficacy of pregabalin in a rat model of spinal nerve ligation (SNL)-induced neuropathic pain.
  
  
  METHODS
  Sprague-Dawley male rats were randomly divided into six groups. The neuropathic pain-relieving properties were measured by plantar test, cold plate test, and hot plate test after administration of pregabalin (i.v) and/or thiamin (i.p) in SNL rats 14 days after operation.
  
  
  RESULTS
  In the therapy period, pregabalin, or thiamin alone all produced antinociceptive effects in rats with neuropathic pain. And combination treatment of thiamin and pregabalin resulted in an enhanced pain relief compared to the administration of pregabalin or thiamin alone.
  
  
  CONCLUSIONS
  Combination of thiamin and pregabalin produces an additive antinociceptive effect in neuropathic pain rats, this drug combination may offer a beneﬁcial treatment option for neuropathic pain.
authors.affiliation: a Department of Pain , Henan Province Hospital , Zhengzhou , China.
authors.forename: Lin
authors.initials: L
authors.lastname: Liu
authors.affiliation: a Department of Pain , Henan Province Hospital , Zhengzhou , China.
authors.forename: Song-He
authors.initials: SH
authors.lastname: Ma
authors.affiliation: a Department of Pain , Henan Province Hospital , Zhengzhou , China.
authors.forename: Ling-Jie
authors.initials: LJ
authors.lastname: Xia
mesh_terms: D000700:Analgesics / Q000627:therapeutic use*; D000704:Analysis of Variance; D000818:Animals; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D006930:Hyperalgesia / Q000188:drug therapy; D008026:Ligation / Q000009:adverse effects; D008297:Male; D009437:Neuralgia / Q000188:drug therapy*; D010147:Pain Measurement; D017288:Pain Threshold; D010812:Physical Stimulation / Q000009:adverse effects; D000069583:Pregabalin / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013127:Spinal Nerves / Q000293:injuries; D013831:Thiamine / Q000627:therapeutic use*; D013997:Time Factors; D014803:Vitamin B Complex / Q000627:therapeutic use*
chemical_list: D000700:Analgesics; D014803:Vitamin B Complex; D000069583:Pregabalin; D013831:Thiamine
keywords: Neuropathic pain; Pregabalin; SNL; Thiamin