title: Zebrafish fin and heart: what's special about regeneration?
abstract: Many organs regenerate well in adult zebrafish, but most research has been directed toward fin and heart regeneration. Cells have been found to remain generally lineage-restricted during regeneration, and proliferative regenerative progenitors can be formed by dedifferentiation from differentiated cells. Recent studies begin to shed light on the molecular underpinnings of differences between development and regeneration. Retinoic acid, BMP and NF-κB signaling are emerging as regulators of cellular dedifferentiation. Reactive oxygen species promote regeneration, and the dynamics of ROS signaling might help explain differences between wound healing and regeneration. Finally, the heart has been added to those organs that require a nerve supply to regenerate, and a trade-off between regeneration and tumor suppression has been proposed to help explain why mammals regenerate poorly.
authors.affiliation: Institute of Biochemistry and Molecular Biology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany.
authors.forename: Ivonne M
authors.initials: IM
authors.lastname: Sehring
authors.affiliation: Institute of Biochemistry and Molecular Biology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany.
authors.forename: Christopher
authors.initials: C
authors.lastname: Jahn
authors.affiliation: Institute of Biochemistry and Molecular Biology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany. Electronic address: gilbert.weidinger@uni-ulm.de.
authors.forename: Gilbert
authors.initials: G
authors.lastname: Weidinger
mesh_terms: D058500:Animal Fins / Q000254:growth & development*; D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000378:metabolism; D054337:Cell Dedifferentiation / Q000235:genetics; D006321:Heart / Q000254:growth & development*; D016328:NF-kappa B / Q000235:genetics; D017382:Reactive Oxygen Species / Q000378:metabolism; D012038:Regeneration / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics; D014212:Tretinoin / Q000378:metabolism; D014945:Wound Healing / Q000235:genetics; D015027:Zebrafish / Q000235:genetics* / Q000254:growth & development
chemical_list: D019485:Bone Morphogenetic Proteins; D016328:NF-kappa B; D017382:Reactive Oxygen Species; D014212:Tretinoin