title: Radiographic and histological evaluation of deproteinized bovine bone mineral vs. deproteinized bovine bone mineral with 10% collagen in ridge preservation. A randomized controlled clinical trial.
abstract: OBJECTIVE
  The aims of this randomized clinical trial were to compare the dimensional changes and the histological composition after using deproteinized bovine bone mineral (DBBM) or deproteinized bovine bone mineral with 10% collagen (DBBM-C) and a collagen membrane in ridge preservation procedures.
  
  
  METHODS
  Patients who required an extraction and a subsequent implant-supported rehabilitation at a non-molar site were recruited. After extraction, a cone beam computed tomography (CBCT) was performed and sites were randomly treated either with DBBM or DBBM-C plus a collagen membrane. At 5 months, before implant placement, a second CBCT was performed and a biopsy of the area was obtained. A blinded investigator superimposed the CBCTs and performed measurements to determine bone volume changes between the two time points. Additionally, a histomorphometric analysis of the biopsies was performed in a blinded manner.
  
  
  RESULTS
  Eleven sites belonged to the DBBM group and eleven to the DBBM-C group. All together, a significant reduction in height and width was observed at 5 months of healing, but no statistically significant differences were observed between the DBBM and the DBBM-C group. The histomorphometric analysis revealed a similar composition in terms of newly formed bone, connective tissue and residual graft particles in both groups.
  
  
  CONCLUSIONS
  Deproteinized bovine bone mineral with 10% collagen showed a similar behaviour as DBBM not only in its capacity to minimize ridge contraction but also from a histological point of view. Thus, both graft materials seem to be suitable for ridge preservation procedures.
authors.affiliation: Department of Periodontology, Universidad Internacional de Cataluña, Barcelona, Spain.
authors.forename: Jose
authors.initials: J
authors.lastname: Nart
authors.affiliation: Department of Periodontology, Universidad Internacional de Cataluña, Barcelona, Spain.
authors.forename: Lucía
authors.initials: L
authors.lastname: Barallat
authors.affiliation: Department of Periodontology, Universidad Internacional de Cataluña, Barcelona, Spain.
authors.forename: Daniel
authors.initials: D
authors.lastname: Jimenez
authors.affiliation: Department of Periodontology, Universidad Internacional de Cataluña, Barcelona, Spain.
authors.forename: Jaume
authors.initials: J
authors.lastname: Mestres
authors.affiliation: Department of Periodontology, Universidad Internacional de Cataluña, Barcelona, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Gómez
authors.affiliation: Department of Anatomical Pathology, Universidad Internacional de Cataluña, Hospital General de Cataluña, Barcelona, Spain.
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Carrasco
authors.affiliation: Department of Periodontology, Universidad Internacional de Cataluña, Barcelona, Spain.
authors.forename: Deborah
authors.initials: D
authors.lastname: Violant
authors.affiliation: Department of Periodontology, Universidad Internacional de Cataluña, Barcelona, Spain.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Ruíz-Magaz
mesh_terms: D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging* / Q000517:prevention & control*; D000540:Alveolar Ridge Augmentation / Q000379:methods*; D000818:Animals; D001706:Biopsy; D002417:Cattle; D003094:Collagen / Q000627:therapeutic use*; D054893:Cone-Beam Computed Tomography; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D019094:Dental Prosthesis, Implant-Supported; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008334:Mandible / Q000601:surgery; D008875:Middle Aged; D008903:Minerals / Q000627:therapeutic use*; D013030:Spain; D013524:Surgical Flaps; D013552:Swine; D014081:Tooth Extraction; D020390:Tooth Socket / Q000601:surgery
chemical_list: C077540:Bio-Oss; D015921:Dental Implants; D008903:Minerals; D003094:Collagen
keywords: biomaterials; bone regeneration; cone beam computed tomography