title: [SIRT1].
abstract: Silent information regulator 2 homolog 1 (SIRT1), a product of the so called "longevity gene", is a protein deacetylase that has been reported to suppress cardiovascular pathologies such as myocardial infarction, and neurodegenerative diseases such as Alzheimer's disease, amyotrophic lateral sclerosis, and Parkinson's disease via anti-apoptosis, anti-inflammation, or increasing mitochondrial biogenesis in model organisms. In addition, SIRT1 can counter cerebral hypoperfusion and ischemia through deacetylating anti-inflammatory and anti-apoptotic molecules and also through deacetylating endothelial nitric oxide synthase and inducing arterial dilation. Since cerebral hypoperfusion/ischemia, inflammation, and apoptosis can induce vascular cognitive impairment, SIRT1 potentiation may provide molecular targets for future therapeutic intervention of vascular cognitive impairment and cerebral infarction.
authors.forename: Yorito
authors.initials: Y
authors.lastname: Hattori
authors.forename: Masafumi
authors.initials: M
authors.lastname: Ihara
mesh_terms: D000107:Acetylation; D000818:Animals; D000893:Anti-Inflammatory Agents; D017209:Apoptosis / Q000187:drug effects; D002544:Cerebral Infarction / Q000235:genetics* / Q000628:therapy*; D015140:Dementia, Vascular / Q000235:genetics / Q000628:therapy; D055808:Drug Discovery; D006801:Humans; D051379:Mice; D058990:Molecular Targeted Therapy; D009569:Nitric Oxide / Q000378:metabolism; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism; D056564:Sirtuin 1 / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*
chemical_list: D000893:Anti-Inflammatory Agents; D009569:Nitric Oxide; D052250:Nitric Oxide Synthase Type III; C447939:SIRT1 protein, human; D056564:Sirtuin 1