title: Correlations Between the Density of Tryptase Positive Mast Cells (DMCT) and that of New Blood Vessels (CD105+) in Patients with Gastric Cancer.
abstract: Mast cells proteases, tryptase and chymase are directly involved in the growth and progression of solid tumors due to their important role in tumor angiogenesis. We examined the density of tryptase positive mast cells and the mean density of new blood vessels in gastric malignant tumors of patients with and without Helicobacter pylori infection, using immunohistochemical staining for tryptase (for mast cells) and CD 105 (for new vessels). Tryptase and CD 105 expression was detected in gastrectomy specimens. In this study, mast cell density correlates with angiogenesis and the growth and progression of gastric cancer. It also shows that the participation of Helicobacter pylori infection in the growth and progress of gastric neoplasia is due to an increase of peritumoral angiogenesis, with subsequent local and distant tumor spread and perivascular growth, but without perineural and nodal involvement.
authors.forename: Gianina Viorica
authors.initials: GV
authors.lastname: Micu
authors.forename: Florica
authors.initials: F
authors.lastname: Stăniceanu
authors.forename: Liana Cătălina
authors.initials: LC
authors.lastname: Sticlaru
authors.forename: Cristiana Gabriela
authors.initials: CG
authors.lastname: Popp
authors.forename: Alexandra Eugenia
authors.initials: AE
authors.lastname: Bastian
authors.forename: Eliza
authors.initials: E
authors.lastname: Gramada
authors.forename: G
authors.initials: G
authors.lastname: Pop
authors.forename: R B
authors.initials: RB
authors.lastname: Mateescu
authors.forename: M
authors.initials: M
authors.lastname: Rimbaş
authors.forename: Bianca
authors.initials: B
authors.lastname: Archip
authors.forename: Coralia
authors.initials: C
authors.lastname: Bleotu
mesh_terms: D000230:Adenocarcinoma / Q000201:enzymology* / Q000378:metabolism / Q000382:microbiology / Q000473:pathology* / Q000601:surgery; D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D016022:Case-Control Studies; D000071063:Endoglin; D005260:Female; D005743:Gastrectomy; D016481:Helicobacter Infections / Q000150:complications; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008407:Mast Cells / Q000378:metabolism*; D008875:Middle Aged; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic; D011237:Predictive Value of Tests; D011379:Prognosis; D011956:Receptors, Cell Surface / Q000378:metabolism*; D012189:Retrospective Studies; D012307:Risk Factors; D012680:Sensitivity and Specificity; D013274:Stomach Neoplasms / Q000201:enzymology* / Q000378:metabolism / Q000382:microbiology / Q000473:pathology* / Q000601:surgery; D053802:Tryptases / Q000378:metabolism*
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; C064206:ENG protein, human; D000071063:Endoglin; D011956:Receptors, Cell Surface; D053802:Tryptases