title: Influence of preoperative sodium concentration on outcome of patients with hepatitis B virus cirrhosis after liver transplantation.
abstract: OBJECTIVE
  Whether preoperative serum sodium concentration could influence post-transplant patients' prognosis remains controversial. The aim of this study was to evaluate the influence of patients' pretransplant sodium concentration on the prognosis after liver transplantation in a cohort of patients with hepatitis B virus-related cirrhosis.
  
  
  METHODS
  Data derived from the Chinese Liver Transplantation Registry system from 1 January 2000 to 31 December 2011 were extracted. The serum sodium concentrations and model for end-stage liver disease scores were recorded at listing before liver transplantation, and the relationship between the above parameters and patients' outcome was analyzed.
  
  
  RESULTS
  A total of 2733 patients were included in this study. Compared with patients in the normal group (serum sodium between 135 and 150 mmol/l), patients in the severe hyponatremia group (<125 mmol/l) (P=0.022) and hypernatremia group (>150 mmol/l) (P=0.008) had a poorer prognosis. No significant differences were found among the moderate hyponatremia group (125-130 mmol/l) (P=0.113) and the mild hyponatremia group (130-135 mmol/l) (P=0.461). The 5-year cumulative survivals for the hyponatremia (≤135 mmol/l), normal (135-150 mmol/l), and hypernatremia (≥150 mmol/l) pretransplant group are 79.52, 82.23, and 69.30%, respectively.
  
  
  CONCLUSIONS
  Our analysis showed that for patients with hepatitis B virus-related cirrhosis in mainland China, patients with abnormal serum sodium concentrations have poorer prognosis; both preoperative hyponatremia and hypernatremia were identified as negative risk factors for patients' outcome.
authors.affiliation: aDepartment of Organ Transplant, First Affiliated Hospital bZhongshan School of Medicine cGuangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology dGuangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), Sun Yat-Sen University, Guangzhou eDepartment of Hepatobiliary Surgery, The University of Hong Kong - Shenzhen Hospital, Shenzhen, Guangdong, China.
authors.forename: Peijie
authors.initials: P
authors.lastname: Wang
authors.forename: Gang
authors.initials: G
authors.lastname: Huang
authors.forename: Ngalei
authors.initials: N
authors.lastname: Tam
authors.forename: Chenglin
authors.initials: C
authors.lastname: Wu
authors.forename: Shunjun
authors.initials: S
authors.lastname: Fu
authors.forename: Bridget P
authors.initials: BP
authors.lastname: Hughes
authors.forename: Linwei
authors.initials: L
authors.lastname: Wu
authors.forename: Xiaoshun
authors.initials: X
authors.lastname: He
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D002681:China; D005260:Female; D006509:Hepatitis B / Q000097:blood / Q000150:complications / Q000401:mortality / Q000601:surgery*; D006801:Humans; D006955:Hypernatremia / Q000097:blood* / Q000150:complications / Q000401:mortality; D007010:Hyponatremia / Q000097:blood* / Q000150:complications / Q000401:mortality; D053208:Kaplan-Meier Estimate; D008103:Liver Cirrhosis / Q000097:blood / Q000401:mortality / Q000601:surgery* / Q000821:virology; D016031:Liver Transplantation / Q000009:adverse effects / Q000401:mortality; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016016:Proportional Hazards Models; D012042:Registries; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012964:Sodium / Q000097:blood*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D012964:Sodium