title: Translation into Portuguese, cross-cultural adaptation and validation of "The European Organization for Research and Treatment of Cancer-Quality of Life Questionnaire-Bone Metastases-22".
abstract: BACKGROUND
  The aim of the present study was to conduct a cross-cultural adaptation (with translation into Brazilian Portuguese) and validation of the European Organization for Research and Treatment of Cancer-Quality of Life Questionnaire-Bone Metastases-22 (EORTC QLQ-BM22).
  
  
  METHODS
  Ninety-five bone metastasis patients (31 men and 64 women, mean age 58.36±8.90 years) took part in the investigation. The translation guide of the EORTC was used to translate from English into Brazilian Portuguese and adapt the instrument culturally. The reliability and the face, content and construct validities were tested.
  
  
  RESULTS
  Internal consistency was estimated using Cronbach's alpha for the total score, pain and functional subscales of the EORTC QLQ-BM22 (0.93, 0.86, 0.90). Reliability was analyzed by Pearson's correlation and intraclass correlation coefficients (ICCs). The correlations were higher than the recommended value of 0.75, which indicated good test-retest reliability. Construct validity was demonstrated by correlation with the questionnaire medical outcome study questionnaire 36-Item Short Form Survey (SF-36). It showed significant correlation between the fields of QLQ-BM22 and the SF-36 (P≤0.001).
  
  
  CONCLUSIONS
  The EORTC QLQ-BM22 was translated into Brazilian Portuguese, was culturally adapted and was proven to be reliable, with face, content and construct validity.
authors.affiliation: Oncology Orthopedic Group of Orthopedic and Traumatology Department, Federal University of São Paulo (UNIFESP/EPM), São Paulo, Brazil. n.miki@unifesp.br.
authors.forename: Natália
authors.initials: N
authors.lastname: Miki-Rosário
authors.affiliation: Oncology Orthopedic Group of Orthopedic and Traumatology Department, Federal University of São Paulo (UNIFESP/EPM), São Paulo, Brazil.
authors.forename: Reynaldo Jesus
authors.initials: RJ
authors.lastname: Garcia Filho
authors.affiliation: Oncology Orthopedic Group of Orthopedic and Traumatology Department, Federal University of São Paulo (UNIFESP/EPM), São Paulo, Brazil.
authors.forename: Jairo Greco
authors.initials: JG
authors.lastname: Garcia
authors.affiliation: Discipline of Plastic Surgery of Federal University of São Paulo (UNIFESP/EPM), São Paulo, Brazil.
authors.forename: Gal Moreira
authors.initials: GM
authors.lastname: Dini
authors.affiliation: European Organization for Research and Treatment of Cancer, EORTC Headquarters, Brussels, Belgium.
authors.forename: Andrew
authors.initials: A
authors.lastname: Bottomley
authors.affiliation: Department of Radiation Oncology, Odette Cancer Centre, University of Toronto, Ontario, Canada.
authors.forename: Edward
authors.initials: E
authors.lastname: Chow
authors.affiliation: Discipline of Plastic Surgery of Federal University of São Paulo (UNIFESP/EPM), São Paulo, Brazil.
authors.forename: Miguel
authors.initials: M
authors.lastname: Sabino Neto
mesh_terms: D001859:Bone Neoplasms / Q000523:psychology / Q000556:secondary*; D003431:Cross-Cultural Comparison; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011174:Portugal; D011594:Psychometrics; D011788:Quality of Life; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires / Q000592:standards*; D014177:Translations
keywords: Bone neoplasms; neoplasm metastasis; quality of life; reproducibility of results; translation