title: A Critical Appraisal of Growth Hormone Therapy in Growth Hormone Deficiency and Turner Syndrome Patients in Turkey.
abstract: Early detection of abnormal growth, identification of the underlying cause, and appropriate treatment of the medical condition is an important issue for children with short stature. Growth hormone (GH) therapy is widely used in GH-deficient children and also in non-GH-deficient short stature cases who have findings conforming to certain indications. Efficacy of GH therapy has been shown in a multitude of short- and long-term studies. Age at onset of GH therapy is the most important factor for a successful treatment outcome. Optimal dosing is also essential. The aim of this review was to focus on challenges in the early diagnosis and appropriate management of short stature due to GH deficiency (GHD) and Turner syndrome. These are the most frequent two indications for GH therapy in Turkey approved by the Ministry of Health for coverage by the national insurance system.
authors.forename: Zehra
authors.initials: Z
authors.lastname: Yavaş Abalı
authors.affiliation: İstanbul University İstanbul Faculty of Medicine, Department of Pediatrics, Division of Pediatric Endocrinology, İstanbul, Turkey, Phone: +90 212 414 20 00 E-mail: feyzad@istanbul.edu.tr.
authors.forename: Feyza
authors.initials: F
authors.lastname: Darendeliler
authors.forename: Olcay
authors.initials: O
authors.lastname: Neyzi
mesh_terms: D002648:Child; D004305:Dose-Response Relationship, Drug; D042241:Early Diagnosis; D005260:Female; D006130:Growth Disorders / Q000188:drug therapy*; D013006:Growth Hormone / Q000172:deficiency* / Q000627:therapeutic use*; D006801:Humans; D016896:Treatment Outcome; D014421:Turkey; D014424:Turner Syndrome / Q000188:drug therapy*
chemical_list: D013006:Growth Hormone