title: Osteoporosis: The Result of an 'Aged' Bone Microenvironment.
abstract: Osteoporosis is an age-related progressive bone disease. Recent advances in epigenetics, cell biology, osteoimmunology, and genetic epidemiology have unraveled new mechanisms and players underlying the pathology of osteoporosis, supporting a model of age-related dysregulation and crosstalk in the bone microenvironment.
authors.affiliation: Department of Oral Biology and Oral Medicine, School of Dentistry, University of California, Los Angeles, CA 90095, USA.
authors.forename: Bo
authors.initials: B
authors.lastname: Yu
authors.affiliation: Department of Oral Biology and Oral Medicine, School of Dentistry, University of California, Los Angeles, CA 90095, USA; Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, Jonsson Comprehensive Cancer Center, Broad Stem Cell Research Institute, University of California, Los Angeles, CA 90095, USA. Electronic address: cwang@dentistry.ucla.edu.
authors.forename: Cun-Yu
authors.initials: CY
authors.lastname: Wang
mesh_terms: D056704:Adaptive Immunity; D000375:Aging; D000818:Animals; D001842:Bone and Bones / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D016503:Drug Delivery Systems; D055808:Drug Discovery; D005260:Female; D006801:Humans; D008297:Male; D010024:Osteoporosis / Q000209:etiology* / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D060449:Wnt Signaling Pathway / Q000187:drug effects
keywords: Wnt signaling; aging; epigenetics; osteoimmunology; osteoporosis