title: Use of anti-Müllerian hormone testing during ovarian reserve screening to identify women at risk of polycystic ovary syndrome.
abstract: OBJECTIVE
  To assess the applicability of anti-Müllerian hormone (AMH) testing in the identification of women at risk for polycystic ovary syndrome (PCOS) when AMH is used in ovarian reserve screening in the general population.
  
  
  METHODS
  A secondary analysis was undertaken of a large cross-sectional study. Women aged 27-37years, presently delaying childbearing but interested in future fertility, completed an online questionnaire to assess knowledge and attitudes about ovarian reserve testing, and underwent serum AMH testing between October 2014 and April 2015 in New York, NY, USA. For the secondary analysis, women considered to have elevated AMH levels (≥4.7ng/mL) were invited for physical examination and transvaginal ultrasonography.
  
  
  RESULTS
  Among 97 women who underwent AMH testing, 32 (33.0%) had elevated AMH levels. Hyperandrogenism was reported by 8 (25.0%) women with elevated AMH and none with AMH concentrations lower than 4.7ng/mL (P<0.001). Irregular menstrual cycles before hormonal contraceptive use were reported by 16 (24.6%) of 65 women with AMH concentrations lower than 4.7ng/mL and 11 (34.4%) with elevated AMH (P=0.34). Of the 20 women with elevated AMH who returned for further evaluation, 16 (80.0%) had polycystic ovaries and 13 (65.0%) were diagnosed with PCOS (Rotterdam criteria).
  
  
  CONCLUSIONS
  When AMH levels are used as a screening test for fertility, elevated concentrations can identify women at risk for PCOS.
authors.affiliation: Obstetrics and Gynecology, Columbia University Medical Center, New York, NY, USA.
authors.forename: Lauren Z
authors.initials: LZ
authors.lastname: Safier
authors.affiliation: Obstetrics and Gynecology, Columbia University Medical Center, New York, NY, USA.
authors.forename: Lisa C
authors.initials: LC
authors.lastname: Grossman
authors.affiliation: Level Health, Inc, New York, NY, USA.
authors.forename: Cariann W
authors.initials: CW
authors.lastname: Chan
authors.affiliation: Obstetrics and Gynecology, Columbia University Medical Center, New York, NY, USA.
authors.forename: Mark V
authors.initials: MV
authors.lastname: Sauer
authors.affiliation: Obstetrics and Gynecology, Columbia University Medical Center, New York, NY, USA.
authors.forename: Rogerio A
authors.initials: RA
authors.lastname: Lobo
authors.affiliation: Obstetrics and Gynecology, Columbia University Medical Center, New York, NY, USA. Electronic address: nd2058@cumc.columbia.edu.
authors.forename: Nataki C
authors.initials: NC
authors.lastname: Douglas
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D017588:Hyperandrogenism / Q000175:diagnosis; D009518:New York; D065851:Ovarian Reserve / Q000502:physiology*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000175:diagnosis*; D011795:Surveys and Questionnaires
chemical_list: D054304:Anti-Mullerian Hormone
keywords: Anti-Müllerian hormone; Ovarian reserve screening; Polycystic ovaries; Polycystic ovary syndrome