title: Skin microrelief profiles as a cutaneous aging index.
abstract: An objective measurement of cutaneous topographical information is important for quantifying the degree of skin aging. Our aim was to improve methods for measuring microrelief patterns using a three-dimensional analysis based on silicone replicas and scanning electron microscope (SEM). Another objective was to compare the results with those obtained using a two-dimensional analysis method based on dermoscopy. Silicone replicas were obtained from forearms, dorsum of the hands and fingers of 51 volunteers. Cutaneous profiles obtained by SEM with silicone replicas showed more consistent correlations with age than data obtained by dermoscopy. This indicates the advantage of three-dimensional topography analysis using silicone replicas and SEM over the widely used dermoscopic assessment. The cutaneous age was calculated using stepwise linear regression, and the result was 57.40-9.47 × (number of furrows on dorsum of the hand) × (width of furrows on dorsum of the hand).
authors.affiliation: Department of Anatomy, Korea University College of Medicine.
authors.forename: Dai Hyun
authors.initials: DH
authors.lastname: Kim
authors.affiliation: Department of Biotechnology, Korea University College of Life Science & Biotechnology.
authors.forename: Yeon Seung
authors.initials: YS
authors.lastname: Rhyu
authors.affiliation: Department of Dermatology, Korea University College of Medicine.
authors.forename: Hyo Hyun
authors.initials: HH
authors.lastname: Ahn
authors.affiliation: School of Electrical Engineering, Korea University, Seoul, Korea.
authors.forename: Eenjun
authors.initials: E
authors.lastname: Hwang
authors.affiliation: Department of Anatomy, Korea University College of Medicine uhmcs@korea.ac.kr.
authors.forename: Chang Sub
authors.initials: CS
authors.lastname: Uhm
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology*; D046169:Dermoscopy / Q000379:methods*; D005260:Female; D005385:Fingers / Q000033:anatomy & histology*; D005542:Forearm / Q000033:anatomy & histology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods; D008855:Microscopy, Electron, Scanning; D012828:Silicones; D012867:Skin / Q000033:anatomy & histology*; D015595:Skin Aging / Q000502:physiology*; D013499:Surface Properties
chemical_list: D012828:Silicones
keywords: dermoscopy; microrelief; scanning electron microscopy; silicone replica; skin aging; three-dimensional topography analysis