title: A spiropyran-based fluorescent probe for the specific detection of β-amyloid peptide oligomers in Alzheimer's disease.
abstract: We report a new spiropyran-based fluorescent probe that exhibits high affinity and specificity towards Aβ oligomers both in vitro and in vivo. This probe can penetrate the blood brain barrier and specifically target Aβ oligomers in the brains of transgenic mice in models for Alzheimer's disease.
authors.affiliation: Department of Chemistry and Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, Shanghai, 200433, P. R. China. yitao@fudan.edu.cn.
authors.forename: Guanglei
authors.initials: G
authors.lastname: Lv
authors.affiliation: Laboratory of Neurodegenerative Diseases and Molecular Imaging, Shanghai University of Medicine & Health Sciences, Shanghai 201318, P. R. China. sunay@sumhs.edu.cn.
authors.forename: Anyang
authors.initials: A
authors.lastname: Sun
authors.affiliation: Department of Chemistry and Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, Shanghai, 200433, P. R. China. yitao@fudan.edu.cn.
authors.forename: Peng
authors.initials: P
authors.lastname: Wei
authors.affiliation: Laboratory of Neurodegenerative Diseases and Molecular Imaging, Shanghai University of Medicine & Health Sciences, Shanghai 201318, P. R. China. sunay@sumhs.edu.cn.
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.affiliation: Department of Chemistry and Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, Shanghai, 200433, P. R. China. yitao@fudan.edu.cn.
authors.forename: Haichuang
authors.initials: H
authors.lastname: Lan
authors.affiliation: Department of Chemistry and Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, Shanghai, 200433, P. R. China. yitao@fudan.edu.cn.
authors.forename: Tao
authors.initials: T
authors.lastname: Yi
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis*; D016229:Amyloid beta-Peptides / Q000032:analysis*; D000818:Animals; D001578:Benzopyrans / Q000008:administration & dosage / Q000737:chemistry*; D004195:Disease Models, Animal; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000008:administration & dosage / Q000737:chemistry*; D007211:Indoles / Q000008:administration & dosage / Q000737:chemistry*; D007274:Injections, Intraperitoneal; D051379:Mice; D008822:Mice, Transgenic; D015394:Molecular Structure; D009574:Nitro Compounds / Q000008:administration & dosage / Q000737:chemistry*; D011789:Quantum Theory
chemical_list: D016229:Amyloid beta-Peptides; D001578:Benzopyrans; D005456:Fluorescent Dyes; D007211:Indoles; D009574:Nitro Compounds; C088184:spiropyran