title: [A potential of selective androgen receptor modulator(SARM)for the therapy of osteoporosis].
abstract: In recent years, the drugs, which show anabolic, effect on bone and muscle without stimulating prostate has been developed. They show tissue-specific selective androgen actions and called selective androgen receptor modulators(SARMs). The development of drug targeting bone and muscle in male is very promising as a treatment tool for osteoporosis and sarcopenia in the near future. The clinical study is under going especially in the field of cachexia associated with cancer, but unfortunately there is no drug in the current market at present. The current situation of the development of SARMs will be reviewed.
authors.affiliation: Department of Endocrinology and Diabetes Mellitus, School of Medicine, Fukuoka University, Japan.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Yanase
mesh_terms: D000726:Androgen Antagonists / Q000737:chemistry / Q000627:therapeutic use*; D000728:Androgens / Q000737:chemistry / Q000627:therapeutic use; D000818:Animals; D015519:Bone Density; D004338:Drug Combinations; D006801:Humans; D010024:Osteoporosis / Q000188:drug therapy* / Q000378:metabolism; D011944:Receptors, Androgen / Q000378:metabolism*
chemical_list: C410798:AR protein, human; D000726:Androgen Antagonists; D000728:Androgens; D004338:Drug Combinations; D011944:Receptors, Androgen