title: One-Pot Synthesis of Substituted Trifluoromethylated 2,3-Dihydro-1H-imidazoles.
abstract: An operationally simple one-pot reaction for the preparation of a novel class of racemic trifluoromethylated 2,3-dihydro-1H-imidazoles derived from electron-poor N,O-acetals and aryl Grignard reagents is described. In addition, access to highly functionalized 2-trifluoromethyl-2,3-dihydro-1H-imidazoles was accomplished by reaction of N-aryl hemiaminal ethers and N-aryl trifluoroethylamines in the presence of an excess of n-butyllithium.
authors.affiliation: Center for Integrated Protein Science Munich (CIPSM) at the Department of Chemistry, Ludwig-Maximilians-University , Butenandtstr. 5-13, 81377 Munich, Germany.
authors.forename: Amrei
authors.initials: A
authors.lastname: Deutsch
authors.affiliation: Center for Integrated Protein Science Munich (CIPSM) at the Department of Chemistry, Ludwig-Maximilians-University , Butenandtstr. 5-13, 81377 Munich, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Jessen
authors.affiliation: Medicinal Chemistry, Merck KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany.
authors.forename: Carl
authors.initials: C
authors.lastname: Deutsch
authors.affiliation: Center for Integrated Protein Science Munich (CIPSM) at the Department of Chemistry, Ludwig-Maximilians-University , Butenandtstr. 5-13, 81377 Munich, Germany.
authors.forename: Konstantin
authors.initials: K
authors.lastname: Karaghiosoff
authors.affiliation: Center for Integrated Protein Science Munich (CIPSM) at the Department of Chemistry, Ludwig-Maximilians-University , Butenandtstr. 5-13, 81377 Munich, Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Hoffmann-Röder