title: Prevalence and cumulative 5-year incidence of chronic lymphocytic leukemia in the adult population in the Russian Federation and Ukraine: Data from the LEUKOSPECT study.
abstract: OBJECTIVE
  LEUKOSPECT was a retrospective, multicenter, epidemiologic study carried out in Russia and Ukraine, aiming to assess the prevalence and cumulative 5-year incidence of chronic lymphocytic leukemia (CLL) in the adult population.
  
  
  METHODS
  All data were collected manually from patient medical records at each of the study sites and from official censuses. CLL prevalence and incidence were determined from a count of CLL cases (previously diagnosed and new cases) in the population who made at least one clinic visit for CLL during the period from 1 January 2009 to 31 December 2013.
  
  
  RESULTS
  The recorded cumulative 5-year incidence of CLL during the study ranged from 1.46 per 100 000 persons (95% CI: 0.85-2.34) in Yekaterinburg, Russia, to 4.34 per 100 000 persons (95% CI: 2.48-7.04) in Luhansk, Ukraine. In 2013, the lowest prevalence of CLL was also recorded in Yekaterinburg: 7.11 per 100 000 persons (95% CI: 5.67-8.81). This was approximately 3.1 times lower than in Luhansk (21.92 per 100 000 population; 95% CI: 17.38-27.28).
  
  
  CONCLUSIONS
  The results of this study show diverse CLL incidence and prevalence patterns in the adult population of the Russian Federation and Ukraine. Authors propose a more comprehensive study with large region involvement to provide a more precise description of the incidence and prevalence of CLL in Eastern European countries and to better understand disparities reported versus the USA and other Western countries.
authors.affiliation: a Country Medical Department , GlaxoSmithKline , Kyiv , Ukraine.
authors.forename: Averyan
authors.initials: A
authors.lastname: Vasylyev
authors.affiliation: b Central City Hospital No. 7 , Yekaterinburg , Russian Federation.
authors.forename: Alexander
authors.initials: A
authors.lastname: Loginov
authors.affiliation: c Regional Clinical Hospital No. 1 , Khabarovsk , Russian Federation.
authors.forename: Valentina
authors.initials: V
authors.lastname: Molostvova
authors.affiliation: d Luhansk Regional Clinical Hospital , Luhansk , Ukraine.
authors.forename: Boris
authors.initials: B
authors.lastname: Rebrov
authors.affiliation: e Department of Internal Medicine , Rio de Janeiro State University , Rio de Janeiro , Brazil.
authors.forename: Marcelo Horacio S
authors.initials: MH
authors.lastname: Pereira
authors.affiliation: f Medical Affairs Department , GlaxoSmithKline , London , UK.
authors.forename: Caroline Wirtzbiki A
authors.initials: CW
authors.lastname: Melo
authors.affiliation: g Russia Medical Department , GlaxoSmithKline , Moscow , Russian Federation.
authors.forename: Janina
authors.initials: J
authors.lastname: Makarova
authors.affiliation: h Medical Franchise Oncology, Novartis Pharma LLC , Moscow , Russia.
authors.forename: Evgeny D
authors.initials: ED
authors.lastname: Pashanov
authors.affiliation: a Country Medical Department , GlaxoSmithKline , Kyiv , Ukraine.
authors.forename: Andriy
authors.initials: A
authors.lastname: Mysnik
mesh_terms: D005260:Female; D006801:Humans; D015994:Incidence; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000453:epidemiology*; D008297:Male; D015995:Prevalence; D012426:Russia; D013997:Time Factors; D014455:Ukraine
keywords: CLL; Chronic lymphocytic leukemia; Epidemiology; Incidence; Prevalence; Russia; Ukraine