title: Philadelphia chromosome-negative acute myeloid leukemia with 11q23/MLL translocation in a patient with chronic myelogenous leukemia.
abstract: Although defined by the presence of t(9;22), chronic myelogenous leukemia (CML) can have other concurrent additional cytogenetic changes, especially during disease progression. Additional chromosomal changes (ACAs) in CML often occur in Philadelphia chromosome (Ph)-positive cells and are associated with disease acceleration and treatment resistance. Occasionally chromosomal changes occur in Ph-negative cells and this phenomenon is often transient and does not correlate with disease progression. Very rarely myelodysplastic syndrome or acute leukemia can develop in Ph-negative cells. In this study, we report an unusual case of acute myeloid leukemia (AML) with 11q23/MLL translocation emerging from Ph-negative cells in a patient with CML.
authors.affiliation: Department of Hematopathology, the University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
authors.forename: Vanya
authors.initials: V
authors.lastname: Jaitly
authors.affiliation: Department of Hematopathology, the University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Hematopathology, the University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
authors.forename: Shimin
authors.initials: S
authors.lastname: Hu
keywords: 11q23; MLL; Philadelphia chromosome (Ph)-negative AML; chronic myelogenous leukemia (CML)