title: Treatment and follow-up of malignant struma ovarii: Regarding two cases.
abstract: Malignant struma ovarii (SO) is a rare tumor, and as a consequence, treatments and follow-up procedures are not clearly established. Presented in this study are two cases of suspicious ovarian masses, resected and corresponding to malignant SO on histopathology. Similar to thyroid cancer, we proposed complementary radioiodine therapy ((131)I) after total thyroidectomy (no malignancy was observed at this level in our two patients). Patients underwent treatment with 3.7 GBq (131)I followed by post-therapy whole-body scintigraphy, which can detect residual disease or occult metastases. Thyroid remnant ablation increases the sensitivity and specificity of follow-up testing using serum thyroglobulin levels as a tumor marker. Our two patients remained disease-free for 3 and 5 years, respectively, after treatment.
authors.affiliation: Department of Nuclear Medicine, Oscar Lambret Center, 3 rue Combemale, 59020 Lille Cedex, France.
authors.forename: Aurore
authors.initials: A
authors.lastname: Oudoux
authors.affiliation: Department of Surgery, Oscar Lambret Center, 3 rue Combemale, 59020 Lille Cedex, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Leblanc
authors.affiliation: Department of Biology, Unit of Morphological and Molecular Pathology, Oscar Lambret Center, 3 rue Combemale, 59020 Lille Cedex, France.
authors.forename: Juliette
authors.initials: J
authors.lastname: Beaujot
authors.affiliation: Department of Nuclear Medicine, Oscar Lambret Center, 3 rue Combemale, 59020 Lille Cedex, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Gauthier-Kolesnikov
keywords: Malignant struma ovarii; Radioactive iodine therapy; Thyroid carcinoma