title: Short-Term Effects and Safety Analysis of Retrograde Autologous Blood Priming for Cardiopulmonary Bypass in Patients with Cardiac Valve Replacement Surgery.
abstract: This randomized, double-blind study evaluated the short-term effects and safety of perioperative retrograde autologous priming (RAP) for cardiopulmonary bypass (CPB) in patients with cardiac replacement surgery to determine if this approach is a better substitute for crystal liquids priming in patients with valvular heart disease. We observed that RAP significantly decreased the actual priming volume, preserved the hematocrit and hemoglobin level during CPB to a certain degree, and decreased lactate accumulation in CPB period. Moreover, RAP lowered the volume of transfusion and dosage blood products. Thus, our results showed that RAP approach effectively improved tissue perfusion and lowered intraoperative Lac levels, by reducing the hemodilution, which safely and reliably improve the microcirculation perfusion.
authors.affiliation: Department of Cardiac Surgery, The Second Affiliated Hospital of Harbin Medical University, Nangang, Harbin, 150086, Heilongjiang, People's Republic of China. drchengming@163.com.
authors.forename: Ming
authors.initials: M
authors.lastname: Cheng
authors.affiliation: Department of Cardiac Surgery, The Second Affiliated Hospital of Harbin Medical University, Nangang, Harbin, 150086, Heilongjiang, People's Republic of China. lijunquan2009@sina.com.
authors.forename: Jun-Quan
authors.initials: JQ
authors.lastname: Li
authors.affiliation: Department of Cardiac Surgery, The Second Affiliated Hospital of Harbin Medical University, Nangang, Harbin, 150086, Heilongjiang, People's Republic of China.
authors.forename: Tian-Chi
authors.initials: TC
authors.lastname: Wu
authors.affiliation: Department of Cardiac Surgery, The Second Affiliated Hospital of Harbin Medical University, Nangang, Harbin, 150086, Heilongjiang, People's Republic of China.
authors.forename: Wei-Chen
authors.initials: WC
authors.lastname: Tian
mesh_terms: D000328:Adult; D016063:Blood Loss, Surgical; D001803:Blood Transfusion; D002315:Cardiopulmonary Bypass; D004311:Double-Blind Method; D005260:Female; D006349:Heart Valve Diseases / Q000601:surgery*; D006400:Hematocrit; D006438:Hemodilution; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D019344:Lactic Acid / Q000378:metabolism; D050866:Liquid Crystals / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D006454:Hemoglobins; D019344:Lactic Acid
keywords: Cardiac valve replacement surgery; Cardiopulmonary bypass; Retrograde autologous blood priming; Valvular heart disease