title: Banff Histopathological Consensus Criteria for Preimplantation Kidney Biopsies.
abstract: The Banff working group on preimplantation biopsy was established to develop consensus criteria (best practice guidelines) for the interpretation of preimplantation kidney biopsies. Digitally scanned slides were used (i) to evaluate interobserver variability of histopathologic findings, comparing frozen sections with formalin-fixed, paraffin-embedded tissue of wedge and needle core biopsies, and (ii) to correlate consensus histopathologic findings with graft outcome in a cohort of biopsies from international medical centers. Intraclass correlations (ICCs) and univariable and multivariable statistical analyses were performed. Good to fair reproducibility was observed in semiquantitative scores for percentage of glomerulosclerosis, arterial intimal fibrosis and interstitial fibrosis on frozen wedge biopsies. Evaluation of frozen wedge and core biopsies was comparable for number of glomeruli, but needle biopsies showed worse ICCs for glomerulosclerosis, interstitial fibrosis and tubular atrophy. A consensus evaluation form is provided to help standardize the reporting of histopathologic lesions in donor biopsies. It should be recognized that histologic parameters may not correlate with graft outcome in studies based on organs deemed to be acceptable after careful clinical assessment. Significant limitations remain in the assessment of implantation biopsies.
authors.affiliation: Department of Pathology & Immunology, Washington University School of Medicine, St Louis, MO.|Nephropath, Little Rock, AR.
authors.forename: H
authors.initials: H
authors.lastname: Liapis
authors.affiliation: Department of Pathology & Immunology, Washington University School of Medicine, St Louis, MO.
authors.forename: J P
authors.initials: JP
authors.lastname: Gaut
authors.affiliation: Piedmont Hospital, Atlanta, GA.
authors.forename: C
authors.initials: C
authors.lastname: Klein
authors.affiliation: Department of Pathology & Internal Medicine, Johns Hopkins University Hospital, Baltimore, MD.
authors.forename: S
authors.initials: S
authors.lastname: Bagnasco
authors.affiliation: Department of Pathology & Internal Medicine, Johns Hopkins University Hospital, Baltimore, MD.
authors.forename: E
authors.initials: E
authors.lastname: Kraus
authors.affiliation: Emory University Hospital, Atlanta, GA.
authors.forename: A B
authors.initials: AB
authors.lastname: Farris
authors.affiliation: IKEM, Prague, Czech Republic.
authors.forename: E
authors.initials: E
authors.lastname: Honsova
authors.affiliation: Transplantation Institute, Medical University of Warsaw, Warsaw, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Perkowska-Ptasinska
authors.affiliation: University of Sao Paulo, Renal Transplant Service, Sao Paulo, Brazil.
authors.forename: D
authors.initials: D
authors.lastname: David
authors.affiliation: INCUCAI (Argentinian Nacional Institute for procurement and Implants) and CUCAIBA (Buenos Aires Inst of procurement and implants), Buenos Aires, Argentina.
authors.forename: J
authors.initials: J
authors.lastname: Goldberg
authors.affiliation: Mayo Clinic, Scottsdale, AZ.
authors.forename: M
authors.initials: M
authors.lastname: Smith
authors.affiliation: Department of Pathology, University of Alberta, Alberta, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Mengel
authors.affiliation: Cedars-Sinai Medical Center, Department of Pathology & Lab Medicine, Los Angeles, CA.
authors.forename: M
authors.initials: M
authors.lastname: Haas
authors.affiliation: Department of Pathology, Cornell University, New York, NY.
authors.forename: S
authors.initials: S
authors.lastname: Seshan
authors.affiliation: Santa Casa de Misericordia de Porto Alegre Hospital and Universidade Federal de Ciências da Saúde de Porto Alegre, Rio Grande do Sul, Brazil.
authors.forename: K L
authors.initials: KL
authors.lastname: Pegas
authors.affiliation: Department of Pharmacy, Barnes-Jewish Hospital, Saint Louis, MO.
authors.forename: T
authors.initials: T
authors.lastname: Horwedel
authors.affiliation: Department of Pathology, University of Pittsburgh, Thomas E Starzl Transplant Institute, Pittsburgh, PA.
authors.forename: Y
authors.initials: Y
authors.lastname: Paliwa
authors.affiliation: Department of Pathology, University of Pittsburgh, Thomas E Starzl Transplant Institute, Pittsburgh, PA.
authors.forename: X
authors.initials: X
authors.lastname: Gao
authors.affiliation: Department of Pathology, University of Pittsburgh, Thomas E Starzl Transplant Institute, Pittsburgh, PA.
authors.forename: D
authors.initials: D
authors.lastname: Landsittel
authors.affiliation: Department of Pathology, University of Pittsburgh, Thomas E Starzl Transplant Institute, Pittsburgh, PA.
authors.forename: P
authors.initials: P
authors.lastname: Randhawa
mesh_terms: D001707:Biopsy, Needle; D006801:Humans; D007668:Kidney / Q000473:pathology* / Q000601:surgery*; D016030:Kidney Transplantation; D014019:Tissue Donors
keywords: biopsy; clinical research/practice; donors and donation: deceased; kidney (allograft) function/dysfunction; kidney failure/injury; pathology/histopathology