title: Role of anti-inflammatory cytokines in pathogenesis of pediatric mycoplasma pneumoniae pneumonia.
abstract: Through detection and analysis of the changes of interleukin (IL)-2 and IL-10 in children with mycoplasma pneumoniae pneumonia (MPP), this study aimed to explore the role of cytokines in the pathogenesis of pediatric MPP as well as immunological pathogenesis of MPP, to provide guidance for clinical diagnosis, assessment and treatment of MPP. Enzyme linked immunosorbent adsorption (ELISA) analysis was applied to determine the expression level of IL-2 and IL-10 in serum. According to the experimental results, we found that the expression levels of IL-2 and IL-10 changed significantly in different phases of MPP in comparison with a healthy control group and a case control group. The expression levels of IL-2 and IL-10 can be used as an important indicator for early diagnosis of MPP. Accordingly, detection of IL-2 and IL-10 is of great significance to the diagnosis of MPP and studies on their roles can provide guidance for treatment.
authors.affiliation: Department of Pediatrics, the First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.
authors.forename: T
authors.initials: T
authors.lastname: Yan
mesh_terms: D002675:Child, Preschool; D016207:Cytokines / Q000502:physiology*; D005260:Female; D006801:Humans; D007223:Infant; D016753:Interleukin-10 / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D008297:Male; D011019:Pneumonia, Mycoplasma / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology
chemical_list: D016207:Cytokines; D007376:Interleukin-2; D016753:Interleukin-10