title: Misregulation of iron homeostasis in amyotrophic lateral sclerosis.
abstract: Iron is essential for all mammalian cells, but it is toxic in excess. Our understanding of molecular mechanisms ensuring iron homeostasis at both cellular and systemic levels has dramatically increased over the past 15 years. However, despite major advances in this field, homeostatic regulation of iron in the central nervous system (CNS) requires elucidation. It is unclear how iron moves in the CNS and how its transfer to the CNS across the blood-brain and the blood-cerebrospinal fluid barriers, which separate the CNS from the systemic circulation, is regulated. Increasing evidence indicates the role of iron dysregulation in neuronal cell death observed in neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). ALS is a progressive neurodegenerative disorder characterized by selective cortical czynand spinal motor neuron dysfunction that results from a complex interplay among various pathogenic factors including oxidative stress. The latter is known to strongly affect cellular iron balance, creating a vicious circle to exacerbate oxidative injury. The role of iron in the pathogenesis of ALS is confirmed by therapeutic effects of iron chelation in ALS mouse models. These models are of great importance for deciphering molecular mechanisms of iron accumulation in neurons. Most of them consist of transgenic rodents overexpressing the mutated human superoxide dismutase 1 (SOD1) gene. Mutations in the SOD1 gene constitute one of the most common genetic causes of the inherited form of ALS. However, it should be considered that overexpression of the SOD1 gene usually leads to increased SOD1 enzymatic activity, a condition which does not occur in human pathology and which may itself change the expression of iron metabolism genes.
authors.affiliation: Zakład Biologii Molekularnej, Instytutu Genetyki i Hodowli Zwierząt PAN w Jastrzębcu.
authors.forename: Anna
authors.initials: A
authors.lastname: Gajowiak
authors.affiliation: Zakład Biologii Molekularnej, Instytutu Genetyki i Hodowli Zwierząt PAN w Jastrzębcu.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Styś
authors.affiliation: Zakład Biologii Molekularnej, Instytutu Genetyki i Hodowli Zwierząt PAN w Jastrzębcu.
authors.forename: Rafał R
authors.initials: RR
authors.lastname: Starzyński
authors.affiliation: Zakład Biologii Molekularnej, Instytutu Genetyki i Hodowli Zwierząt PAN w Jastrzębcu.
authors.forename: Robert
authors.initials: R
authors.lastname: Staroń
authors.affiliation: Zakład Biologii Molekularnej, Instytutu Genetyki i Hodowli Zwierząt PAN w Jastrzębcu.
authors.forename: Paweł
authors.initials: P
authors.lastname: Lipiński
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000378:metabolism* / Q000503:physiopathology; D000818:Animals; D016923:Cell Death; D002490:Central Nervous System / Q000378:metabolism / Q000503:physiopathology; D006706:Homeostasis; D006801:Humans; D007501:Iron / Q000378:metabolism* / Q000502:physiology; D009046:Motor Neurons / Q000378:metabolism* / Q000502:physiology; D009154:Mutation; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000235:genetics*
chemical_list: D007501:Iron; D013482:Superoxide Dismutase