title: Treatment of bisphosphonate-related osteonecrosis of the jaw using platelet-rich fibrin.
abstract: BACKGROUND
  Bisphosphonates are commonly prescribed antiresorptive agents for the management of patients with osteoporosis, Paget's disease, multiple myeloma, and metastatic tumors. Platelet-rich fibrin (PRF) is a second generation platelet concentrate, and has the ability of regulating the inflammation and stimulation of chemotactic agents. The aim of this report is to present the treatment of Stage-3 bisphosphonate-related osteonecrosis of the jaw (BRONJ) by PRF.
  
  
  METHODS
  A 77-year-old male patient with Stage-3 BRONJ was treated with minimal surgical operations and PRF membrane. The patient was followed up for 18 months, and there was no recurrence or exposure.
  
  
  CONCLUSIONS
  PRF may promote the healing of both bone and soft tissues even in Stage-3 patients. This technique is an alternative treatment modality for the closure of bone exposure and tissue healing in BRONJ patients.
authors.affiliation: a Genome and Stem Cell Center and Faculty of Dentistry, Department of Oral and Maxillofacial Surgery , Erciyes University , Kayseri , Turkey.
authors.forename: Zeynep Burçin
authors.initials: ZB
authors.lastname: Gönen
authors.affiliation: b Faculty of Dentistry, Department of Oral and Maxillofacial Surgery , Erciyes University , Kayseri , Turkey.
authors.forename: Canay
authors.initials: C
authors.lastname: Yılmaz Asan
mesh_terms: D000368:Aged; D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000000981:diagnostic imaging / Q000628:therapy*; D054893:Cone-Beam Computed Tomography; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D000073183:Platelet-Rich Fibrin; D011862:Radiography, Panoramic; D016896:Treatment Outcome
keywords: Bisphosphonate; Osteonecrosis; Platelet-rich fibrin