title: Squamous cell carcinoma of the rectum: a consequence of immunosuppression resulting from inhibiting tumour necrosis factor (TNF)?
abstract: Treatment with tumour necrosis factor (TNF) antagonists may lead to enhanced susceptibility to certain malignancies. In particular, an association is seen emerging between TNF antagonists and development of squamous cell carcinomas (SCCs) of the skin (in association with psoriasis), the oral cavity, and in the anogenital areas (possibly related to prior human papilloma virus infection). We present here a case of a 53-year old woman with a history of severe rheumatoid arthritis (RA), most recently treated with the TNF antagonist etanercept plus methotrexate, presented to our service after several months of increasing left pelvis and buttock pain. Evaluation with a computerised tomography (CT)-directed biopsy of a pelvic side wall mass revealed a metastatic SCC. On a fluorodeoxyglucose (FDG) positron-emission tomography (PET) an additional area of uptake was identified in the left posterior rectum corresponding to a 1 cm nodule palpable on digital exam. Colonoscopic biopsy revealed a basaloid SCC of the rectum as the likely primary site. Immunosuppression following TNF antagonist therapy may have given arise to this unrestrained neoplastic growth. It thereby underscores the need for an initial baseline study of risk factors and identification of patients who are at higher risk for development of a malignancy, in order to achieve a diagnosis at an early stage.
authors.affiliation: Department of Medicine, Perlmutter Cancer Center at the New York University Langone Medical Center, New York, NY 10016, USA.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Silverton
authors.affiliation: Department of Radiology, Perlmutter Cancer Center at the New York University Langone Medical Center, New York, NY 10016, USA.
authors.forename: Roy A
authors.initials: RA
authors.lastname: Raad
authors.affiliation: Department of Radiation Oncology, Perlmutter Cancer Center at the New York University Langone Medical Center, New York, NY 10016, USA.
authors.forename: Leah
authors.initials: L
authors.lastname: Katz
authors.affiliation: Department of Medicine, Perlmutter Cancer Center at the New York University Langone Medical Center, New York, NY 10016, USA.
authors.forename: Andrea
authors.initials: A
authors.lastname: Downey
authors.affiliation: Department of Medicine, Perlmutter Cancer Center at the New York University Langone Medical Center, New York, NY 10016, USA.
authors.forename: Franco M
authors.initials: FM
authors.lastname: Muggia
keywords: TNF antagonists; etanercept; rectal cancer; rheumatoid arthritis; secondary malignancies; squamous cell cancer