title: Spatiotemporal Co-existence of Female Thyroid and Breast Cancers in Hangzhou, China.
abstract: Thyroid and breast cancers (TC, BC) are common female malignant tumors worldwide. Studies suggest that TC patients have a higher BC risk, and vice versa. However, it has not been investigated quantitatively if there is an association between the space-time TC and BC incidence distributions at the population level. This work aims to answer this question. 5358 TC and 8784 BC (female) cases were diagnosed in Hangzhou (China, 2008-2012). Pearson and Spearman rank correlation coefficients of the TC and BC incidences were high, and their patterns were geographically similar. The spatiotemporal co-existence of TC and BC distributions was investigated using the integrative disease predictability (IDP) criterion: if TC-BC association is part of the disease mapping knowledge bases, it should yield improved space-time incidence predictions. Improved TC (BC) incidence predictions were generated when integrating both TC and BC data than when using only TC (BC) data. IDP consistently demonstrated the spatiotemporal co-existence of TC and BC distributions throughout Hangzhou (2008-2012), which means that when the population experiences high incidences of one kind of cancer attention should be paid to the other kind of cancer too. The strength of TC-BC association was measured by the IDP coefficients and incidence prediction accuracy.
authors.affiliation: College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, China.
authors.forename: Xufeng
authors.initials: X
authors.lastname: Fei
authors.affiliation: Institute of Islands and Coastal Ecosystems, Zhejiang University, Zhoushan, China.|Department of Geography, San Diego State University, San Diego, CA, USA.
authors.forename: George
authors.initials: G
authors.lastname: Christakos
authors.affiliation: Institute of Islands and Coastal Ecosystems, Zhejiang University, Zhoushan, China.
authors.forename: Zhaohan
authors.initials: Z
authors.lastname: Lou
authors.affiliation: Hangzhou Center for Disease Control and Prevention, Hangzhou, China.
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Ren
authors.affiliation: Hangzhou Center for Disease Control and Prevention, Hangzhou, China.
authors.forename: Qingmin
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Institute of Islands and Coastal Ecosystems, Zhejiang University, Zhoushan, China.
authors.forename: Jiaping
authors.initials: J
authors.lastname: Wu
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000453:epidemiology*; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D012307:Risk Factors; D062211:Spatio-Temporal Analysis; D013964:Thyroid Neoplasms / Q000453:epidemiology*