title: Diagnostic Value of Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Detecting Residual or Recurrent Prostate Cancer After Radical Prostatectomy: A Pooled Analysis of 12 Individual Studies.
abstract: The objective of this study is to determine the diagnostic value of dynamic contrast-enhanced MRI (DCE-MRI) in patients with recurrent or residual prostate cancer (PCa) after radical prostatectomy. Studies were systematically searched in the PubMed, EMBASE, Cochrane library, SCI, CBM, CNKI, VIP, Wan Fang, and other databases. Additional studies were manually searched using the references of the retrieved articles. The retrieved deadline was Sep. 6th, 2014. Selection of eligible studies for inclusion was based on the inclusion and exclusion criteria, and the quality of the studies was reviewed based on the QUADAS criteria. The Meta Disc 1.4 and Stata 12.1 software were used for meta-analysis, and a summary receiver operating characteristic curve was constructed. The patient-based pooled weighted estimates of the sensitivity, specificity, diagnostic odds ratio, and 95 % confidence interval were calculated. Seven articles (12 studies) were included in the meta-analysis. The pooled estimates of the sensitivity, specificity, and the area under the curve were 0.88 (95 % CI 0.84-0.91), 0.87 (95 % CI  0.81-0.92), and 0.9391, respectively. The diagnostic odds ratio (DOR) was 50.4 (95 % CI 26.0-97.6) and Q* was 0.8764. DCE-MRI has high sensitivity and specificity in the evaluation of locally recurrent or residual PCa after radical prostatectomy.
authors.affiliation: Liaoning Cancer Hospital & Institute, Dalian Medical University Clinical Oncology College, Shenyang, 110042, People's Republic of China.
authors.forename: Tao
authors.initials: T
authors.lastname: Yu
authors.affiliation: Liaoning Cancer Hospital & Institute, Dalian Medical University Clinical Oncology College, Shenyang, 110042, People's Republic of China.
authors.forename: Nan
authors.initials: N
authors.lastname: Meng
authors.affiliation: Liaoning Cancer Hospital & Institute, Dalian Medical University Clinical Oncology College, Shenyang, 110042, People's Republic of China.
authors.forename: Da
authors.initials: D
authors.lastname: Chi
authors.affiliation: Liaoning Cancer Hospital & Institute, Dalian Medical University Clinical Oncology College, Shenyang, 110042, People's Republic of China.
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Liaoning Cancer Hospital & Institute, Dalian Medical University Clinical Oncology College, Shenyang, 110042, People's Republic of China.
authors.forename: Zhekun
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Liaoning Cancer Hospital & Institute, Dalian Medical University Clinical Oncology College, Shenyang, 110042, People's Republic of China. drluoyahong@163.com.
authors.forename: Yahong
authors.initials: Y
authors.lastname: Luo
mesh_terms: D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging*; D018365:Neoplasm, Residual; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D012680:Sensitivity and Specificity
keywords: Magnetic resonance imaging; Meta-analysis; Prostate cancer; Prostatectomy; Recurrence