title: Evaluation of ethyl N-(2-phenethyl) carbamate analogues as biofilm inhibitors of methicillin resistant Staphylococcus aureus.
abstract: A small molecule library consisting of 45 compounds was synthesized based on the bacterial metabolite ethyl N-(2-phenethyl) carbamate. Screening of the compounds revealed a potent analogue capabale of inhibiting several strains of Methicillin Resistant S. aureus biofilms with low to moderate micromolar IC50 values.
authors.affiliation: Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, USA. ccmeland@ncsu.edu.
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Stephens
authors.affiliation: Department of Chemistry, Mahidol University, Bangkok, Thailand 10400.
authors.forename: Nisakorn
authors.initials: N
authors.lastname: Yodsanit
authors.affiliation: Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, USA. ccmeland@ncsu.edu.
authors.forename: Christian
authors.initials: C
authors.lastname: Melander
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects*; D002219:Carbamates / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000502:physiology; D008826:Microbial Sensitivity Tests; D054852:Small Molecule Libraries / Q000737:chemistry / Q000494:pharmacology; D013203:Staphylococcal Infections / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D002219:Carbamates; D054852:Small Molecule Libraries