title: N-Heterocyclic molecule-capped gold nanoparticles as effective antibiotics against multi-drug resistant bacteria.
abstract: We demonstrate that N-heterocyclic molecule-capped gold nanoparticles (Au NPs) have broad-spectrum antibacterial activity. Optimized antibacterial activity can be achieved by using different initial molar ratios (1 : 1 and 10 : 1) of N-heterocyclic prodrugs and the precursor of Au NPs (HAuCl4). This work opens up new avenues for antibiotics based on Au NPs.
authors.affiliation: College of Resources and Environmental Sciences, China Agricultural University, 2 YuanMingYuan West Road, HaiDian District, Beijing 100193, China. ruiyukui@163.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Feng
authors.forename: Wenwen
authors.initials: W
authors.lastname: Chen
authors.forename: Yuexiao
authors.initials: Y
authors.lastname: Jia
authors.forename: Yue
authors.initials: Y
authors.lastname: Tian
authors.forename: Yuyun
authors.initials: Y
authors.lastname: Zhao
authors.forename: Fei
authors.initials: F
authors.lastname: Long
authors.forename: Yukui
authors.initials: Y
authors.lastname: Rui
authors.forename: Xingyu
authors.initials: X
authors.lastname: Jiang
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D024901:Drug Resistance, Multiple, Bacterial; D006046:Gold; D053768:Metal Nanoparticles
chemical_list: D000900:Anti-Bacterial Agents; D006046:Gold