title: Xenotropic Murine Leukemia Virus-Related Virus (XMRV) and the Safety of the Blood Supply.
abstract: In 2006, a new virus, xenotropic murine leukemia virus-related virus (XMRV), was discovered in a cohort of U.S. men with prostate cancer. Soon after this initial finding, XMRV was also detected in samples from patients with chronic fatigue syndrome (CFS). The blood community, which is highly sensitive to the threat of emerging infectious diseases since the HIV/AIDS crisis, recommended indefinite deferral of all blood donors with a history of CFS. As XMRV research progressed, conflicting results emerged regarding the importance of this virus in the pathophysiology of prostate cancer and/or CFS. Molecular biologists traced the development of XMRV to a recombination event in a laboratory mouse that likely occurred circa 1993. The virus was propagated via cell lines derived from a tumor present in this mouse and spread through contamination of laboratory samples. Well-controlled experiments showed that detection of XMRV was due to contaminated samples and was not a marker of or a causal factor in prostate cancer or CFS. This paper traces the development of XMRV in the prostate and CFS scientific communities and explores the effect it had on the blood community.
authors.affiliation: Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA john4613@umn.edu.
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Johnson
authors.affiliation: Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: Claudia S
authors.initials: CS
authors.lastname: Cohn
mesh_terms: D000818:Animals; D001769:Blood / Q000821:virology; D019143:Evolution, Molecular; D015673:Fatigue Syndrome, Chronic / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D008297:Male; D051379:Mice; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000209:etiology*; D012192:Retroviridae Infections / Q000150:complications* / Q000635:transmission* / Q000821:virology; D065227:Transfusion Reaction; D058008:Xenotropic murine leukemia virus-related virus / Q000235:genetics / Q000302:isolation & purification*