title: [Interest of amoxicillin-clavulanic acid combination in urology: An update].
abstract: OBJECTIVE
  This is a review article aiming to bring the place and manner of use of amoxicillin-clavulanic acid in urology.
  
  
  METHODS
  Data collection on the conditions of use of amoxicillin-clavulanic acid in urology has been performed from the Medline database. The following keywords were used: amoxicillin; clavulanic acid; urine; diffusion; pharmacokinetics. The selection was based on the methodology, language of publication (English/French), relevance to the topic and date of publication of the articles collected.
  
  
  RESULTS
  Overall, it is clear from the literature and the national and international guidelines that amoxicillin-clavulanic acid in urinary infections can not be used in probabilistic. However, this association remains valid excepted in the treatment of male urinary tract infections due to a probable fault prostatic diffusion. Note that changing the critical concentrations by the CA-SFM/EUCAST for cystitis of this association should allow an extension of its indication in this situation. Serious adverse effects of amoxicillin-clavulanic acid remain rare.
  
  
  CONCLUSIONS
  If long, the amoxicillin-clavulanic acid played a role of first order in the field of urology, the association has given way to other molecules because of the emergence of resistance. However, A-AC keeps indications in the field of antibiotic therapy in urinary tract infections, surgical antimicrobial prophylaxis and postoperative infections in urology.
authors.affiliation: Service d'urologie, CHRU de Tours, Tours, France; Université François-Rabelais de Tours, PRES ; Centre Val de Loire Université, 37000 Tours, France.
authors.forename: F
authors.initials: F
authors.lastname: Bruyère
authors.affiliation: Unité des maladies infectieuses, hôpital universitaire Paris Île-de-France Ouest, Garches, AP-HP, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Dihn
authors.affiliation: Service des maladies infectieuses et tropicales, CHRU de Nîmes, Nîmes, France; Inserm U1047, 30908 Nîmes cedex 2, France.
authors.forename: A
authors.initials: A
authors.lastname: Sotto
mesh_terms: D019980:Amoxicillin-Potassium Clavulanate Combination / Q000627:therapeutic use*; D006801:Humans; D017410:Practice Guidelines as Topic; D014552:Urinary Tract Infections / Q000188:drug therapy*; D065093:beta-Lactamase Inhibitors / Q000627:therapeutic use*
chemical_list: D065093:beta-Lactamase Inhibitors; D019980:Amoxicillin-Potassium Clavulanate Combination
keywords: Acide clavulanique; Amoxicillin; Amoxicilline; Clavulanic acid; Infection urinaire; Urinary tract infection; Urine; Urologie; Urology