title: A novel guluronate oligomer improves intestinal transit and survival in cystic fibrosis mice.
abstract: Cystic fibrosis (CF) patients experience intestinal complications characterized by the accumulation of thick viscous mucus. CF mice were utilized to determine if a novel guluronate oligomer, OligoG, may be a potential therapy in reducing intestinal mucus and subsequent CF-related intestinal manifestations.
  
  
  
  Intestinal transit, intestinal histology, survival and growth were examined in wildtype and CF mice on regular water and OligoG.
  
  
  
  OligoG improves intestinal transit and survival in CF mice by reducing the accumulation of intestinal mucus. OligoG's ability to directly bind mucin, disrupt mucin interaction and/or sequester calcium allowing for mucin expansion may explain the decrease in mucus accumulation.
authors.affiliation: Department of Genetics and Genome Sciences, Case Western Reserve University, United States.
authors.forename: Megan
authors.initials: M
authors.lastname: Vitko
authors.affiliation: Department of Pediatrics, Case Western Reserve University, United States.
authors.forename: Dana M
authors.initials: DM
authors.lastname: Valerio
authors.affiliation: AlgiPharma AS, Norway.
authors.forename: Philip D
authors.initials: PD
authors.lastname: Rye
authors.affiliation: AlgiPharma AS, Norway.
authors.forename: Edvar
authors.initials: E
authors.lastname: Onsøyen
authors.affiliation: AlgiPharma AS, Norway.
authors.forename: Astrid H
authors.initials: AH
authors.lastname: Myrset
authors.affiliation: AlgiPharma AS, Norway.
authors.forename: Arne
authors.initials: A
authors.lastname: Dessen
authors.affiliation: Department of Genetics and Genome Sciences, Case Western Reserve University, United States; Department of Pediatrics, Case Western Reserve University, United States.
authors.forename: Mitchell L
authors.initials: ML
authors.lastname: Drumm
authors.affiliation: Department of Genetics and Genome Sciences, Case Western Reserve University, United States; Department of Pediatrics, Case Western Reserve University, United States.
authors.forename: Craig A
authors.initials: CA
authors.lastname: Hodges
mesh_terms: D000464:Alginates / Q000494:pharmacology*; D000818:Animals; D003550:Cystic Fibrosis / Q000188:drug therapy / Q000378:metabolism; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000378:metabolism; D005772:Gastrointestinal Transit / Q000187:drug effects*; D007419:Intestinal Secretions / Q000378:metabolism; D007421:Intestine, Small / Q000378:metabolism / Q000503:physiopathology; D051379:Mice; D009093:Mucus / Q000378:metabolism; D009844:Oligosaccharides / Q000494:pharmacology*; D016896:Treatment Outcome
chemical_list: D000464:Alginates; D009844:Oligosaccharides; D019005:Cystic Fibrosis Transmembrane Conductance Regulator
keywords: Cystic fibrosis; Genetically modified mouse; Intestinal transit; Mucus