title: Expression of the Lymphocyte Chemokine XCL1 in Lung Tissue of COPD Mice, and Its Relationship to CD4(+)/CD8(+) Ratio and IL-2.
abstract: We tested the role of the lymphocyte chemokine XCL1 in a murine model of chronic obstructive pulmonary disease (COPD). COPD was instigated in mice by a 12-week exposure to cigarette smoke. Some COPD animals additionally received intranasal injections of recombinant XCL1. We demonstrated that the expression of CD4(+) T cells diminished, while CD8(+) counts increased in the lungs of COPD mice, and that these changes were further aggravated by exogenous XCL1. The levels of XCL1 negatively correlated with CD4(+)/CD8(+) ratio (r = -0.945, p < 0.05). In addition, the levels of this chemokine negatively correlated with the levels of interleukin-2, the lymphokine that is produced by activated CD4(+). This observation further supported negative association between XCL1 and CD4(+) response in an experimental model of COPD. In conclusion, murine model of COPD is characterized by elevated levels of XCL1, increased counts of CD8(+) T cells and diminished ratio of CD4(+)/CD8(+) cells, and decreased activity of CD4(+) T cells. This indicates that XCL1 is involved in chronic inflammatory processes in COPD and may be an important pharmacological target in this disease.
authors.affiliation: The Longgang District Central Hospital of Shenzhen, Shenzhen, 518116, Guangdong, China. drzhuosongming@163.com.
authors.forename: Songming
authors.initials: S
authors.lastname: Zhuo
authors.affiliation: The Longgang District Central Hospital of Shenzhen, Shenzhen, 518116, Guangdong, China.
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.affiliation: The Longgang District Central Hospital of Shenzhen, Shenzhen, 518116, Guangdong, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, 519041, Guangdong, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Peng
authors.affiliation: The Peking University Shenzhen Hospital, Shenzhen, 518116, Guangdong, China.
authors.forename: Anying
authors.initials: A
authors.lastname: Xu
authors.affiliation: The Longgang District Central Hospital of Shenzhen, Shenzhen, 518116, Guangdong, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Ge
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology*; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology*; D019744:Chemokines, C / Q000235:genetics* / Q000378:metabolism*; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D007150:Immunohistochemistry; D007376:Interleukin-2 / Q000378:metabolism; D008168:Lung / Q000378:metabolism* / Q000473:pathology; D008297:Male; D051379:Mice; D029424:Pulmonary Disease, Chronic Obstructive / Q000378:metabolism / Q000473:pathology*
chemical_list: D019744:Chemokines, C; D007376:Interleukin-2; C486249:Xcl1 protein, mouse
keywords: Chronic obstructive pulmonary disease; Interleukin-2; T lymphocyte subsets; XCL1