title: [Metabolic syndrome, non alcoholic hepatic steatopathy and hepatocellular carcinoma: so dangerous liaisons].
abstract: Obesity and the metabolic syndrome are fast-growing epidemics associated with an increased risk for many types of cancer. In the liver, inflammatory and angiogenic changes due to insulin resistance and fatty liver disease are associated with an increased incidence of liver cancer. Regardless of underlying liver disease, cirrhosis remains the most important risk factor for hepatocellular carcinoma (HCC) although cases of HCC arising without cirrhosis do not exclude the possibility of a direct carcinogenesis secondary to non-alcoholic fatty liver disease. Moreover, metabolic syndrome and its different features may also increase the risk of HCC in the setting of chronic liver diseases of other causes, such as viral hepatitis or alcohol abuse. Taking into account all these data, it is necessary to better determine the risk of developing HCC in patients with metabolic syndrome to improve the screening guidelines and develop prophylactic treatments in this setting.
authors.forename: Olivier
authors.initials: O
authors.lastname: Rosmorduc
authors.forename: Laetitia
authors.initials: L
authors.lastname: Fartoux
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000209:etiology*; D048909:Diabetes Complications / Q000150:complications; D018450:Disease Progression; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology*; D024821:Metabolic Syndrome / Q000150:complications*; D065626:Non-alcoholic Fatty Liver Disease / Q000150:complications*; D012307:Risk Factors