title: Pressor recovery after acute stress is impaired in high fructose-fed Lean Zucker rats.
abstract: Insulin resistance is a powerful predictor of cardiovascular disease; however, the mechanistic link remains unclear. This study aims to determine if early cardiovascular changes associated with short-term fructose feeding in the absence of obesity manifest as abnormal blood pressure control. Metabolic dysfunction was induced in Lean Zucker rats by short-term high-fructose feeding. Rats were implanted with telemetry devices for the measurement of mean arterial blood pressure (MAP) and subjected to air jet stress at 5 and 8 weeks after feeding. Additional animals were catheterized under anesthesia for the determination of MAP and blood flow responses in the hind limb and mesenteric vascular beds to intravenous injection of isoproterenol (0.001-0.5 μm), a β-adrenergic agonist. Metabolic dysfunction in high-fructose rats was not accompanied by changes in 24-h MAP Yet, animals fed a high-fructose diet for 8 weeks exhibited a marked impairment in blood pressure recovery after air-jet stress. Dose-dependent decreases in MAP and peripheral blood flow in response to isoproterenol treatment were significantly attenuated in high-fructose rats. These data suggest that impaired blood pressure recovery to acute mental stress precedes the onset of hypertension in the early stages of insulin resistance. Further, blunted responses to isoproterenol implicate β2-adrenergic sensitivity as a possible mechanism responsible for altered blood pressure control after short-term high-fructose feeding.
authors.affiliation: Vascular Biology Center, Georgia Regents University, Augusta, Georgia.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Thompson
authors.affiliation: Vascular Biology Center, Georgia Regents University, Augusta, Georgia.
authors.forename: Gerard
authors.initials: G
authors.lastname: D'Angelo
authors.affiliation: Vascular Biology Center, Georgia Regents University, Augusta, Georgia.
authors.forename: James D
authors.initials: JD
authors.lastname: Mintz
authors.affiliation: Vascular Biology Center, Georgia Regents University, Augusta, Georgia.
authors.forename: David J
authors.initials: DJ
authors.lastname: Fulton
authors.affiliation: Vascular Biology Center, Georgia Regents University, Augusta, Georgia dstepp@gru.edu.
authors.forename: David W
authors.initials: DW
authors.lastname: Stepp
mesh_terms: D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004040:Dietary Carbohydrates / Q000009:adverse effects / Q000494:pharmacology*; D005632:Fructose / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D006614:Hindlimb / Q000098:blood supply; D007333:Insulin Resistance; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008638:Mesenteric Arteries / Q000502:physiology; D051381:Rats; D011924:Rats, Zucker; D012039:Regional Blood Flow; D013315:Stress, Psychological / Q000378:metabolism / Q000503:physiopathology*
chemical_list: D000318:Adrenergic beta-Agonists; D004040:Dietary Carbohydrates; D005632:Fructose; D007545:Isoproterenol
keywords: Fructose; insulin resistance; pressor responses; stress; β‐adrenergic