title: Positive correlation between functional disability, excessive daytime sleepiness, and fatigue in relapsing-remitting multiple sclerosis.
abstract: METHODS
  Retrospective review of medical records from patients with multiple sclerosis to collect data on severity of fatigue, disability, daytime sleepiness, and depression. From 912 medical records reviewed, 122 reported daytime sleepiness: 67% had relapsing remitting, 12% had primary progressive, and 21% had secondary progressive.
  
  
  RESULTS
  In 95% of the patients with relapsing remitting who complained of daytime sleepiness and fatigue, association was found between these symptoms and neurological disability. Patients with relapsing remitting who complained of daytime sleepiness and fatigue also experienced depression (p = 0.001). No association between fatigue, excessive daytime sleepiness, depression, and disability was found in patients with progressive disease.
  
  
  CONCLUSIONS
  In relapsing remitting, there is correlation between functional disability, excessive daytime sleepiness and fatigue, a finding not confirmed in primary progressive and secondary progressive form.
authors.affiliation: Universidade Federal de São Paulo, Universidade Federal de São Paulo, Departamento de Neurologia e Neurocirurgia, São Paulo SP , Brasil, Universidade Federal de São Paulo, Departamento de Neurologia e Neurocirurgia, Setor de Doenças Desmielizantes e Neuro-sono, São Paulo SP, Brasil.
authors.forename: Douglas Martins
authors.initials: DM
authors.lastname: Braga
authors.affiliation: Universidade Federal de São Paulo, Universidade Federal de São Paulo, Departamento de Neurologia e Neurocirurgia, São Paulo SP , Brasil, Universidade Federal de São Paulo, Departamento de Neurologia e Neurocirurgia, Setor de Doenças Desmielizantes e Neuro-sono, São Paulo SP, Brasil.
authors.forename: Gilmar Fernandes do
authors.initials: GF
authors.lastname: Prado
authors.affiliation: Universidade Federal de São Paulo, Universidade Federal de São Paulo, Departamento de Neurologia e Neurocirurgia, São Paulo SP , Brasil, Universidade Federal de São Paulo, Departamento de Neurologia e Neurocirurgia, Setor de Doenças Desmielizantes e Neuro-sono, São Paulo SP, Brasil.
authors.forename: Denis Bernardi
authors.initials: DB
authors.lastname: Bichueti
authors.affiliation: Universidade Federal de São Paulo, Universidade Federal de São Paulo, Departamento de Neurologia e Neurocirurgia, São Paulo SP , Brasil, Universidade Federal de São Paulo, Departamento de Neurologia e Neurocirurgia, Setor de Doenças Desmielizantes e Neuro-sono, São Paulo SP, Brasil.
authors.forename: Enedina Maria Lobato de
authors.initials: EM
authors.lastname: Oliveira
mesh_terms: D000328:Adult; D000368:Aged; D004185:Disability Evaluation; D005221:Fatigue / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000150:complications* / Q000503:physiopathology; D012189:Retrospective Studies; D012720:Severity of Illness Index; D012893:Sleep Wake Disorders / Q000209:etiology* / Q000503:physiopathology; D055815:Young Adult