title: The association between polyomavirus BK strains and BKV viruria in liver transplant recipients.
abstract: BK virus (BKV) is a polyomavirus that cause of allograft dysfunction among kidney transplant recipients. The role of BKV infection in non-renal solid organ transplant recipients is not well understood neither for the relationship between various BKV strains with occurrence of BKV viral viruria. This study aimed to understand the prevalence of BKV infection and identified of BKV various strains in the urine of liver transplant recipients. There was not significant difference of renal outcome between high BKV viruria and low BKV viruria in the liver transplant recipients. The WW-non-coding control region (NCCR) BKV detected in urine was associated with higher urinary BKV load, whereas the Dunlop-NCCR BKV was detected in the urine of low urinary BKV load. An in vitro cultivation system demonstrated that WW-BKV strain exhibiting the higher viral DNA replication efficiency and higher BKV load. Altogether, this is the first study to demonstrate the impact of BKV strains on the occurrence of BK viruria in the liver transplant recipients.
authors.affiliation: Department of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.|Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Robert Y L
authors.initials: RY
authors.lastname: Wang
authors.affiliation: Kidney Research Center and Department of Nephrology, Chang Gung Memorial Hospital, Taipei, Taiwan.|Department of Medicine, Chang Gung University, Taoyuan, Taiwan.|Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Yi-Jung
authors.initials: YJ
authors.lastname: Li
authors.affiliation: Department of General Surgery, Chang Gung Memorial Hospital, Taipei, Taiwan.
authors.forename: Wei-Chen
authors.initials: WC
authors.lastname: Lee
authors.affiliation: Kidney Research Center and Department of Nephrology, Chang Gung Memorial Hospital, Taipei, Taiwan.|Department of Medicine, Chang Gung University, Taoyuan, Taiwan.|Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Hsin-Hsu
authors.initials: HH
authors.lastname: Wu
authors.affiliation: Kidney Research Center and Department of Nephrology, Chang Gung Memorial Hospital, Taipei, Taiwan.|Department of Medicine, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Chan-Yu
authors.initials: CY
authors.lastname: Lin
authors.affiliation: Kidney Research Center and Department of Nephrology, Chang Gung Memorial Hospital, Taipei, Taiwan.|Department of Medicine, Chang Gung University, Taoyuan, Taiwan.|Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Cheng-Chia
authors.initials: CC
authors.lastname: Lee
authors.affiliation: Kidney Research Center and Department of Nephrology, Chang Gung Memorial Hospital, Taipei, Taiwan.|Department of Medicine, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Yung-Chang
authors.initials: YC
authors.lastname: Chen
authors.affiliation: Kidney Research Center and Department of Nephrology, Chang Gung Memorial Hospital, Taipei, Taiwan.|Department of Medicine, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Cheng-Chieh
authors.initials: CC
authors.lastname: Hung
authors.affiliation: Kidney Research Center and Department of Nephrology, Chang Gung Memorial Hospital, Taipei, Taiwan.|Department of Medicine, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Chih-Wei
authors.initials: CW
authors.lastname: Yang
authors.affiliation: Kidney Research Center and Department of Nephrology, Chang Gung Memorial Hospital, Taipei, Taiwan.|Department of Medicine, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Ya-Chung
authors.initials: YC
authors.lastname: Tian
mesh_terms: D001739:BK Virus / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D006801:Humans; D007668:Kidney / Q000821:virology; D016030:Kidney Transplantation / Q000379:methods; D008099:Liver / Q000821:virology*; D016031:Liver Transplantation / Q000379:methods; D008297:Male; D008875:Middle Aged; D011120:Polyomavirus; D027601:Polyomavirus Infections / Q000652:urine*; D015995:Prevalence; D012307:Risk Factors; D014184:Transplantation, Homologous / Q000379:methods; D014412:Tumor Virus Infections / Q000652:urine*; D014556:Urine / Q000821:virology*; D019562:Viral Load / Q000379:methods; D014779:Virus Replication / Q000235:genetics
chemical_list: D004279:DNA, Viral