title: The association between home vs. ambulatory night-time blood pressure and end-organ damage in the general population.
abstract: The aim of this study was to test the agreement between night-time home and night-time ambulatory blood pressure (BP) and to compare their associations with hypertensive end-organ damage for the first time in the general population.
  
  
  
  A population sample of 248 participants underwent measurements for night-time home BP (three measurements on two nights with a timer-equipped home device), night-time ambulatory BP, pulse wave velocity (PWV), carotid intima-media thickness (IMT) and echocardiographic left ventricular mass index (LVMI).
  
  
  
  No significant or systematic differences were observed between mean night-time ambulatory and home BPs (systolic/diastolic difference: 0.7 ± 7.6/0.2 ± 6.0 mmHg, P = 0.16/0.64). All night-time home and ambulatory BPs were positively correlated with PWV, IMT and LVMI (P < 0.01 for all). No significant differences in Pearson's correlations between end-organ damage and night-time home or ambulatory BP were observed (P ≥ 0.11 for all comparisons using Dunn and Clark's Z), except for a slightly stronger correlation between PWV and ambulatory SBP than for home SBP (r = 0.57 vs. 0.50, P = 0.03). The adjusted R of all multivariable-adjusted models for PWV, IMT or LVMI that included night-time home or ambulatory SBP/DBP were within 2/1%.
  
  
  
  Our study demonstrates that night-time home and ambulatory measurements produce similar BP values that have comparable associations with end-organ damage in the general population even when a clinically feasible measurement protocol is used for measuring night-time home BP. In the future, night-time home BP measurement may offer a feasible and easily accessible alternative to ambulatory monitoring for the measurement of night-time BP.
authors.affiliation: aDivision of Medicine, Turku University Hospital bDepartment of Health, National Institute for Health and Welfare, Turku cDepartment of Health, National Institute for Health and Welfare, Helsinki dDepartment of Medicine, University of Turku, Turku, Finland eThe Framingham Heart Study, Framingham, Massachusetts, USA.
authors.forename: Annika S
authors.initials: AS
authors.lastname: Lindroos
authors.forename: Jouni K
authors.initials: JK
authors.lastname: Johansson
authors.forename: Pauli J
authors.initials: PJ
authors.lastname: Puukka
authors.forename: Ilkka
authors.initials: I
authors.lastname: Kantola
authors.forename: Veikko
authors.initials: V
authors.lastname: Salomaa
authors.forename: Eeva P
authors.initials: EP
authors.lastname: Juhanoja
authors.forename: Sam S E
authors.initials: SS
authors.lastname: Sivén
authors.forename: Pekka
authors.initials: P
authors.lastname: Jousilahti
authors.forename: Antti M
authors.initials: AM
authors.lastname: Jula
authors.forename: Teemu J
authors.initials: TJ
authors.lastname: Niiranen
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory / Q000706:statistics & numerical data*; D059168:Carotid Intima-Media Thickness; D004452:Echocardiography; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D063177:Pulse Wave Analysis