title: BLCA-4 and UBC combined detection for early diagnosis of bladder cancer.
abstract: The objective of the present study was to report the clinical significance of bladder cancer specific nuclear matrix protein 4 (BLCA-4) and urinary bladder cancer (UBC) on early diagnosis of bladder cancers. Enzyme-linked immunosorbent assay (ELISA) was used to detect BLCA-4 and UBC of 56 bladder cancer patients and 26 patients with urinary tract benign diseases, serving as controls. Urine exfoliated cell test was performed, and then the significance of BLCA-4 and UBC on the diagnosis of bladder cancers was analyzed. The sensitivity of BLCA-4 and UBC of the bladder cancer patients was significantly higher than that of the urine exfoliated cell test (P less than 0.05). The difference of BLCA-4 and UBC was not significant (P >0.05). The difference of BLCA-4 and UBC in the tumors with different gradings and stagings was not significant (P >0.05). Combined detection of BLCA-4 and UBC could improve the diagnosis sensitivity and specificity of bladder cancers with the advantages of high maneuverability, repeatability and objective results.
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou city, PR China.
authors.forename: L
authors.initials: L
authors.lastname: Cui
authors.affiliation: Department of Pathology, Henan Cancer Hospital, Zhengzhou city, PR China.
authors.forename: M M
authors.initials: MM
authors.lastname: Sun
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou city, PR China.
authors.forename: Z H
authors.initials: ZH
authors.lastname: Zhao
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou city, PR China.
authors.forename: J P
authors.initials: JP
authors.lastname: Yang
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou city, PR China.
authors.forename: Y P
authors.initials: YP
authors.lastname: Zheng
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou city, PR China.
authors.forename: L L
authors.initials: LL
authors.lastname: He
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou city, PR China.
authors.forename: K S
authors.initials: KS
authors.lastname: Chen
authors.affiliation: Medical oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou City, PR China.
authors.forename: Q X
authors.initials: QX
authors.lastname: Fan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000652:urine*; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000652:urine*; D012680:Sensitivity and Specificity; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000652:urine; D009363:Neoplasm Proteins
chemical_list: D014408:Biomarkers, Tumor; D009687:Nuclear Proteins; C413062:BLCA-4 protein, human; D009363:Neoplasm Proteins