title: Effect of IL-1β and IL-1RN polymorphisms in carcinogenesis of the gastric mucosa in patients infected with Helicobacter pylori in Algeria.
abstract: BACKGROUND
  Infection with Helicobacter pylori is considered a potential risk of developing gastric cancer in association with contributing host genetic factor. IL-1β and IL-1RN polymorphisms appear to maintain and promote Helicobacter pylori infection and to stimulate neoplastic growth of the gastric mucosa.
  
  
  OBJECTIVE
  In order to elucidate the effect of these polymorphisms in combination with gastric cancer in a population from northwestern Algeria, a case-control study was carried out on 79 patients infected with H. pylori with chronic atrophic gastritis and/or gastric carcinoma, and 32 subjects were recruited as case-control. IL-1β-31 bi-allelic and IL-1β-511 bi-allelic polymorphisms and IL-1RN penta-allelic were genotyped.
  
  
  RESULTS
  IL-1β-31C was associated with an increased risk of developing gastric carcinoma (OR=4.614 [1.43-14.81], p=0.01). However, IL-1RN2 heterozygous allele type was significantly associated with chronic atrophic gastritis (OR=4.2 [1.23-3.61], p=0.022). IL-1β-511T was associated with an increased risk of development of chronic atrophic gastritis (OR=4.286 [1.54-11.89], p=0.005).
  
  
  CONCLUSIONS
  IL-1β and IL-1RN polymorphisms associated with H. pylori infection contribute to the development of chronic atrophic gastritis and gastric carcinomas in an Algerian population. The alleles IL-1β-31C and IL-1RN were associated with an increased risk of developing gastric carcinoma, and IL-1β-511T with an increased risk of developing chronic atrophic gastritis with no significant association of developing gastric carcinoma.
authors.affiliation: Department of Biology, Faculty of Natural and Life Sciences, Djillali LIABES University, Sidi-Bel-Abbes, Algeria; drici.amine@gmail.com.
authors.forename: Amine El-Mokhtar
authors.initials: Ael-M
authors.lastname: Drici
authors.affiliation: Department of Biology, Faculty of Natural and Life Sciences, Djillali LIABES University, Sidi-Bel-Abbes, Algeria.
authors.forename: Soraya
authors.initials: S
authors.lastname: Moulessehoul
authors.affiliation: Department of Biology, Faculty of Natural and Life Sciences, Djillali LIABES University, Sidi-Bel-Abbes, Algeria.
authors.forename: Abdelkarim
authors.initials: A
authors.lastname: Tifrit
authors.affiliation: Department of Biology, Faculty of Natural and Life Sciences, Djillali LIABES University, Sidi-Bel-Abbes, Algeria.
authors.forename: Mustapha
authors.initials: M
authors.lastname: Diaf
authors.affiliation: Department of Gastroenterology, University Hospital of Sidi-Bel-Abbes, Sidi-Bel-Abbes, Algeria.
authors.forename: Douidi Kara
authors.initials: DK
authors.lastname: Turki
authors.affiliation: Department of Biology, Faculty of Sciences, Hassiba Ben Bouali University, Chlef, Algeria.
authors.forename: Meryem
authors.initials: M
authors.lastname: Bachir
authors.affiliation: Anatomopathology Department, University Hospital of Sidi-Bel-Abbes, Sidi-Bel-Abbes, Algeria.
authors.forename: Abdenacer
authors.initials: A
authors.lastname: Tou
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000462:Algeria; D016022:Case-Control Studies; D005260:Female; D005753:Gastric Mucosa / Q000821:virology*; D020022:Genetic Predisposition to Disease; D016480:Helicobacter pylori / Q000235:genetics*; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics*; D053583:Interleukin-1beta / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D013274:Stomach Neoplasms / Q000235:genetics* / Q000821:virology; D055815:Young Adult
chemical_list: C508585:IL1B protein, human; C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D053583:Interleukin-1beta
keywords: Helicobacter pylori; IL-1RN; IL-1β; gastric mucosa