title: Risperidone-induced topological alterations of anatomical brain network in first-episode drug-naive schizophrenia patients: a longitudinal diffusion tensor imaging study.
abstract: It remains unclear whether the topological deficits of the white matter network documented in cross-sectional studies of chronic schizophrenia patients are due to chronic illness or to other factors such as antipsychotic treatment effects. To answer this question, we evaluated the white matter network in medication-naive first-episode schizophrenia patients (FESP) before and after a course of treatment.
  
  
  
  We performed a longitudinal diffusion tensor imaging study in 42 drug-naive FESP at baseline and then after 8 weeks of risperidone monotherapy, and compared them with 38 healthy volunteers. Graph theory was utilized to calculate the topological characteristics of brain anatomical network. Patients' clinical state was evaluated using the Positive and Negative Syndrome Scale (PANSS) before and after treatment.
  
  
  
  Pretreatment, patients had relatively intact overall topological organizations, and deficient nodal topological properties primarily in prefrontal gyrus and limbic system components such as the bilateral anterior and posterior cingulate. Treatment with risperidone normalized topological parameters in the limbic system, and the enhancement positively correlated with the reduction in PANSS-positive symptoms. Prefrontal topological impairments persisted following treatment and negative symptoms did not improve.
  
  
  
  During the early phase of antipsychotic medication treatment there are region-specific alterations in white matter topological measures. Limbic white matter topological dysfunction improves with positive symptom reduction. Prefrontal deficits and negative symptoms are unresponsive to medication intervention, and prefrontal deficits are potential trait biomarkers and targets for negative symptom treatment development.
authors.affiliation: Mental Health Institute of the Second Xiangya Hospital,Central South University,139 Middle Renmin Road,Changsha,Hunan 410011,People's Republic of China.
authors.forename: M
authors.initials: M
authors.lastname: Hu
authors.affiliation: Mental Health Institute of the Second Xiangya Hospital,Central South University,139 Middle Renmin Road,Changsha,Hunan 410011,People's Republic of China.
authors.forename: X
authors.initials: X
authors.lastname: Zong
authors.affiliation: Key Laboratory for NeuroInformation of the Ministry of Education,School of Life Science and Technology,University of Electronic Science and Technology of China,Chengdu 610054,People's Republic of China.
authors.forename: J
authors.initials: J
authors.lastname: Zheng
authors.affiliation: Division of Molecular Imaging and Neuropathology,New York State Psychiatric Institute and Departments of Psychiatry and Radiology,Columbia University,1051 Riverside Drive,Box 42,New York,NY 10032,USA.
authors.forename: J J
authors.initials: JJ
authors.lastname: Mann
authors.affiliation: Mental Health Institute of the Second Xiangya Hospital,Central South University,139 Middle Renmin Road,Changsha,Hunan 410011,People's Republic of China.
authors.forename: Z
authors.initials: Z
authors.lastname: Li
authors.affiliation: Division of Molecular Imaging and Neuropathology,New York State Psychiatric Institute and Departments of Psychiatry,Columbia University,New York, NY 10032,USA.
authors.forename: S P
authors.initials: SP
authors.lastname: Pantazatos
authors.affiliation: Key Laboratory for NeuroInformation of the Ministry of Education,School of Life Science and Technology,University of Electronic Science and Technology of China,Chengdu 610054,People's Republic of China.
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.affiliation: Mental Health Institute of the Second Xiangya Hospital,Central South University,139 Middle Renmin Road,Changsha,Hunan 410011,People's Republic of China.
authors.forename: Y
authors.initials: Y
authors.lastname: Liao
authors.affiliation: Mental Health Institute of the Second Xiangya Hospital,Central South University,139 Middle Renmin Road,Changsha,Hunan 410011,People's Republic of China.
authors.forename: Y
authors.initials: Y
authors.lastname: He
authors.affiliation: Mental Health Institute of the Second Xiangya Hospital,Central South University,139 Middle Renmin Road,Changsha,Hunan 410011,People's Republic of China.
authors.forename: J
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Radiology,Henan Mental Hospital, the Second Affiliated Hospital of Xinxiang Medical University,Xinxiang,Henan 453002,People's Republic of China.
authors.forename: D
authors.initials: D
authors.lastname: Sang
authors.affiliation: Department of Radiology,Henan Mental Hospital, the Second Affiliated Hospital of Xinxiang Medical University,Xinxiang,Henan 453002,People's Republic of China.
authors.forename: H
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Mental Health Institute of the Second Xiangya Hospital,Central South University,139 Middle Renmin Road,Changsha,Hunan 410011,People's Republic of China.
authors.forename: J
authors.initials: J
authors.lastname: Tang
authors.affiliation: Key Laboratory for NeuroInformation of the Ministry of Education,School of Life Science and Technology,University of Electronic Science and Technology of China,Chengdu 610054,People's Republic of China.
authors.forename: H
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Psychiatry,Henan Mental Hospital, the Second Affiliated Hospital of Xinxiang Medical University,Xinxiang,Henan 453002,People's Republic of China.
authors.forename: L
authors.initials: L
authors.lastname: Lv
authors.affiliation: Mental Health Institute of the Second Xiangya Hospital,Central South University,139 Middle Renmin Road,Changsha,Hunan 410011,People's Republic of China.
authors.forename: X
authors.initials: X
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D056324:Diffusion Tensor Imaging; D005500:Follow-Up Studies; D006801:Humans; D008032:Limbic System / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D008137:Longitudinal Studies; D009415:Nerve Net / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D018967:Risperidone / Q000008:administration & dosage / Q000494:pharmacology*; D012559:Schizophrenia / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D066127:White Matter / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D018967:Risperidone
keywords: First-episode schizophrenia; longitudinal studies; networks; schizophrenia; topology; white matter