title: Low energy cyclotron production and cyclometalation chemistry of iridium-192.
abstract: This work demonstrates the labelling of a novel class of iridium lumophore with radioiridium, as proof-of-feasibility for producing and using the medically useful isotope iridium-192. Natural osmium was electroplated onto silver target backings in basic media and irradiated for up to two hours with ≤20μA of 12.8MeV protons. A range of iridium isotopes were generated, characterized and quantified using γ-spectroscopy methods. The target material was removed from the backings via oxidative dissolution with hydrogen peroxide, and the iridium radioisotopes isolated using an anion exchange resin. Both no-carrier-added as well as carrier-added formulations were then used in subsequent cyclometalation reactions.
authors.affiliation: Department of Chemistry, Simon Fraser University, Burnaby, Canada.
authors.forename: G
authors.initials: G
authors.lastname: Langille
authors.affiliation: Life Sciences Division, TRIUMF, Vancouver, Canada.
authors.forename: H
authors.initials: H
authors.lastname: Yang
authors.affiliation: Life Sciences Division, TRIUMF, Vancouver, Canada.
authors.forename: S K
authors.initials: SK
authors.lastname: Zeisler
authors.affiliation: Life Sciences Division, TRIUMF, Vancouver, Canada.
authors.forename: C
authors.initials: C
authors.lastname: Hoehr
authors.affiliation: Department of Chemistry, Simon Fraser University, Burnaby, Canada.
authors.forename: T
authors.initials: T
authors.lastname: Storr
authors.affiliation: Department of Chemistry, Simon Fraser University, Burnaby, Canada; Life Sciences Division, TRIUMF, Vancouver, Canada.
authors.forename: C
authors.initials: C
authors.lastname: Andreoiu
authors.affiliation: Department of Chemistry, Simon Fraser University, Burnaby, Canada; Life Sciences Division, TRIUMF, Vancouver, Canada.
authors.forename: P
authors.initials: P
authors.lastname: Schaffer
keywords: Cyclometalation; Cyclotron; Iridium; Irradiation; Osmium