title: Mechanistic insights into mitral regurgitation due to atrial fibrillation: "Atrial functional mitral regurgitation".
abstract: Mitral regurgitation (MR) is common, and definitive management of significant MR often requires percutaneous or surgical correction. Lone atrial fibrillation has been proposed to result in "atrial functional mitral regurgitation (AFMR)" via left atrial enlargement and mitral annular dilation. Patients with AFMR may represent a subgroup in which a rhythm control strategy may be preferred and catheter ablation is a promising nonsurgical therapy. This review discusses the anatomy of the mitral valve apparatus and MR classification schemes. Potential mechanisms in the pathogenesis of AFMR the implications for treatment will be discussed in detail.
authors.affiliation: Cardiovascular Division, Perelman School of Medicine, Hospital of the University of Pennsylvania, University of Pennsylvania, Philadelphia, PA.
authors.forename: Jackson J
authors.initials: JJ
authors.lastname: Liang
authors.affiliation: Cardiovascular Division, Perelman School of Medicine, Hospital of the University of Pennsylvania, University of Pennsylvania, Philadelphia, PA. Electronic address: fsilvest@mail.med.upenn.edu.
authors.forename: Frank E
authors.initials: FE
authors.lastname: Silvestry
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D017115:Catheter Ablation; D019560:Echocardiography, Three-Dimensional; D017548:Echocardiography, Transesophageal; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008943:Mitral Valve / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology*; D008944:Mitral Valve Insufficiency / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D020127:Recovery of Function; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D000889:Anti-Arrhythmia Agents
keywords: Ablation; Atrial fibrillation; Atrial functional mitral regurgitation; Functional mitral regurgitation; Left atrium; Mitral annulus; Mitral regurgitation