title: Prevention and Periodontal Treatment in Down Syndrome Patients: A Systematic Review.
abstract: The aim of this systematic literature review was to evaluate which type of periodontal preventive and therapeutic approaches presents superior outcomes in patients with Down syndrome (DS). Studies reporting different methods of periodontal care from DS patients were considered eligible. Included clinical studies should indicate at least two periodontal parameters in different periods of assessment. Screening of the articles, data extraction and quality assessment were conducted independently and in duplicate. Electronic search according to the PICO search, with both Key-words and MESH terms were conducted in MEDLINE, EMBASE and CENTRAL databases until March 2016. Manual search was conducted in four journals, namely Journal of Periodontology, Journal of Clinical Periodontology, Journal of Periodontal Research and Special Care in Dentistry and their electronic databases were searched. Electronic and manual search resulted in 763 papers, and of them 744 were excluded after title/abstract assessment. The full text of 19 potentially eligible publications was screened and 9 studies met inclusion criteria. The results demonstrated the importance to introduce youngest DS patients in preventive programs, as well as participation of parents, caregivers or institutional attendants in supervising/performing oral hygiene. In studies with higher frequency of attendance, all age groups presented superior preventive and therapeutic results, irrespective of the therapeutic approach used (surgical/nonsurgical/periodontal care program). The important factors for reducing periodontal parameters were the frequency of the appointments and association with chlorhexidine/plaque disclosing agents as adjuvant treatment. This systematic review demonstrated that early introduction in periodontal care, participation of parents/caregivers/institutional attendants, frequency of attendance and association with chemical adjuvants (independently of the periodontal treatment adopted) seems to improve periodontal outcomes in preventive and periodontal treatment of DS patients. Registration number (Prospero): CRD42016038433.
authors.affiliation: Division of Periodontics, Department of Prosthodontics, Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil.
authors.forename: Rafael
authors.initials: R
authors.lastname: Ferreira
authors.affiliation: Division of Periodontics, Department of Prosthodontics, Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil.
authors.forename: Raphaella Coelho
authors.initials: RC
authors.lastname: Michel
authors.affiliation: Division of Periodontics, Department of Prosthodontics, Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil.
authors.forename: Sebastião Luiz Aguiar
authors.initials: SL
authors.lastname: Greghi
authors.affiliation: Division of Periodontics, Department of Prosthodontics, Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil.
authors.forename: Maria Lúcia Rubo de
authors.initials: ML
authors.lastname: Resende
authors.affiliation: Division of Periodontics, Department of Prosthodontics, Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil.
authors.forename: Adriana Campos Passanezi
authors.initials: AC
authors.lastname: Sant'Ana
authors.affiliation: Division of Periodontics, Department of Prosthodontics, Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil.
authors.forename: Carla Andreotti
authors.initials: CA
authors.lastname: Damante
authors.affiliation: Division of Periodontics, Department of Prosthodontics, Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil.
authors.forename: Mariana Schutzer Ragghianti
authors.initials: MS
authors.lastname: Zangrando
mesh_terms: D002986:Clinical Trials as Topic; D003729:Dental Care; D004314:Down Syndrome / Q000150:complications*; D006801:Humans; D009910:Oral Hygiene; D063868:Patient Outcome Assessment; D010510:Periodontal Diseases / Q000150:complications* / Q000517:prevention & control* / Q000628:therapy; D010517:Periodontics; D012306:Risk