title: Anti-melanin deposition activity of ceramicines from Chisocheton ceramicus.
abstract: The ceramicines, a series of limonoids from Chisocheton ceramicus (Meliaceae), were evaluated for anti-melanin deposition activity on α-melanocyte stimulating hormone (α-MSH) and 3-isobutyl-1-methylxanthine (IBMX)-treated B16-F10 melanoma cell, and several ceramicines were found to be active. The structure-activity relationship of ceramicines as anti-melanin deposition inhibitors was deduced. Furthermore, the mechanism of anti-melanin deposition activity of ceramicine B, a major constituent of C. ceramicus that showed potent anti-melanin deposition activity, was investigated. Tyrosinase enzymatic activity and tyrosinase mRNA expression were not affected by ceramicine B. The anti-melanin deposition activity of ceramicine B was shown to be related to the downregulation of tyrosinase protein expression. These results suggest that ceramicines have potential to be used as depigmentation agents.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo, 142-8501, Japan.
authors.forename: Chie
authors.initials: C
authors.lastname: Iijima
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo, 142-8501, Japan.
authors.forename: Chin Piow
authors.initials: CP
authors.lastname: Wong
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo, 142-8501, Japan.
authors.forename: Alfarius Eko
authors.initials: AE
authors.lastname: Nugroho
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo, 142-8501, Japan.
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Sotozono
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo, 142-8501, Japan.
authors.forename: Saki
authors.initials: S
authors.lastname: Someya
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo, 142-8501, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Hirasawa
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo, 142-8501, Japan.
authors.forename: Toshio
authors.initials: T
authors.lastname: Kaneda
authors.affiliation: Department of Chemistry, Faculty of Science, University Malaya, 50603, Kuala Lumpur, Malaysia.
authors.forename: A Hamid A
authors.initials: AH
authors.lastname: Hadi
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo, 142-8501, Japan. moritah@hoshi.ac.jp.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morita
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D015536:Down-Regulation / Q000187:drug effects; D036701:Limonins / Q000494:pharmacology*; D008543:Melanins / Q000096:biosynthesis / Q000378:metabolism*; D008546:Melanoma, Experimental / Q000378:metabolism*; D029582:Meliaceae / Q000737:chemistry*; D051379:Mice; D014442:Monophenol Monooxygenase / Q000378:metabolism*; D010858:Pigmentation / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D036701:Limonins; D008543:Melanins; D010936:Plant Extracts; C000588427:ceramicine B; D014442:Monophenol Monooxygenase
keywords: Anti-melanin deposition; Ceramicines; Chisocheton ceramicus; Limonoids; Tyrosinase protein