title: The Effect of Hydrogen Sulphide on Experimental Cerebral Vasospasm.
abstract: OBJECTIVE
  Cerebral vasospasm is the primary cause of morbidity and mortality after subarachnoid hemorrhage (SAH). Hydrogen Sulfide (H < sub > 2 < /sub > S), a gaseous neurotransmitter, is produced in many tissues including the central nervous system (CNS). The vasodilatatory effect of H2S has been shown in the CNS; however, its role in cerebral vasospasm has not been investigated before.
  
  
  METHODS
  The rats were divided into 8 groups: control, SAH, sodium hydrosulphide (NaHS), propargylglycine (PPG), aminooxy acetic acid (AOAA), SAH+NaHS, SAH+PPG, and SAH+AOAA. After establishing experimental SAH, the basilar artery and brain stem were harvested at 24th hours. The diameter and wall thickness of basilar artery were measured. Production of H2S was assessed by showing the activity of cystathionine ?-synthase (CBS) and cystathionine ?-lyase enzymes (CSE).
  
  
  RESULTS
  NaHS treatment significantly reduced vasospasm at 24 hours following SAH. This vasodilatatory effect was correlated with the CSE expression in basilar artery. CSE and CBS enzyme expressions were significantly lower in brain stem and basilar artery in PPG and AOAA-treated groups. PPG and AOAA treatments exerted a vasoconstrictive effect in the basilar artery. There were statistically significant differences between NaHS, PPG and AOAA groups, in terms of basilar artery luminal diameter.
  
  
  CONCLUSIONS
  H < sub > 2 < /sub > S may have a therapeutic potential in the treatment of vasospasm with its vasodilatator activity.
authors.affiliation: Gazi University, School of Medicine, Neuropsychiatry Center, Ankara, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Emmez
authors.forename: Alp Ozgun
authors.initials: AO
authors.lastname: Borcek
authors.forename: Ipek Isik
authors.initials: II
authors.lastname: Gonul
authors.forename: Hayrunnisa Bolay
authors.initials: HB
authors.lastname: Belen
authors.forename: Ihsan
authors.initials: I
authors.lastname: Solaroglu
authors.forename: M Kemali
authors.initials: MK
authors.lastname: Baykaner
mesh_terms: D000818:Animals; D001488:Basilar Artery / Q000187:drug effects; D006862:Hydrogen Sulfide / Q000494:pharmacology*; D008297:Male; D051381:Rats; D013345:Subarachnoid Hemorrhage / Q000150:complications; D014665:Vasodilator Agents / Q000494:pharmacology*; D020301:Vasospasm, Intracranial / Q000209:etiology
chemical_list: D014665:Vasodilator Agents; D006862:Hydrogen Sulfide