title: Histiocytosis With Raisinoid Nuclei: A Unifying Concept for Lesions Reported Under Different Names as Nodular Mesothelial/Histiocytic Hyperplasia, Mesothelial/Monocytic Incidental Cardiac Excrescences, Intralymphatic Histiocytosis, and Others: A Report of 50 Cases.
abstract: We report 50 cases of peculiar histiocytic proliferations occurring in diverse body sites that currently bear various names, including nodular mesothelial/histiocytic hyperplasia, nodular histiocytic aggregates, mesothelial/monocytic incidental cardiac excrescences, reactive eosinophilic pleuritis, histioeosinophilic granuloma of the thymus, and intralymphatic histiocytosis. They can sometimes cause considerable differential diagnostic difficulties by resembling a metastatic carcinoma or Langerhans cell histiocytosis. Several previous publications have established a link between some of these conditions, suggesting that these are merely variations within a histopathologic spectrum, affecting different organs and bearing different names based on a particular location. However, no publication has ever comprehensively addressed all of these lesions together in one study in an attempt to explain and discuss their striking analogy. Having studied a large series of cases we provide evidence that all these lesions share the same morphologic, immunohistochemical, and pathogenetic properties, thus they all represent the same pathologic process and should be referred to as such. Taking into account their typical nuclear features we propose a collective term "histiocytosis with raisinoid nuclei" for this spectrum of conditions.
authors.affiliation: *Department of Pathology, Charles University, Biomedical Center †Department of Pathology, Charles University, Medical Faculty and Charles University Hospital Plzen, Plzen ‡Department of Pathology, First Faculty of Medicine and General University Hospital, Charles University in Prague, Prague ¶Department of Pathology, Regional Hospital Benesov, Benesov, Czech Republic §Institute of Pathology, Friedrich-Alexander University Erlangen-Nürnberg, University Hospital, Erlangen ∥Dermatopathologische Gemeinschaftspraxis, Friedrichshafen, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Michal
authors.forename: Dmitry V
authors.initials: DV
authors.lastname: Kazakov
authors.forename: Pavel
authors.initials: P
authors.lastname: Dundr
authors.forename: Kvetoslava
authors.initials: K
authors.lastname: Peckova
authors.forename: Abbas
authors.initials: A
authors.lastname: Agaimy
authors.forename: Heinz
authors.initials: H
authors.lastname: Kutzner
authors.forename: Frantisek
authors.initials: F
authors.lastname: Havlicek
authors.forename: Ondřej
authors.initials: O
authors.lastname: Daum
authors.forename: Magdalena
authors.initials: M
authors.lastname: Dubova
authors.forename: Michal
authors.initials: M
authors.lastname: Michal
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000032:analysis; D002467:Cell Nucleus / Q000473:pathology*; D002675:Child, Preschool; D005260:Female; D015614:Histiocytosis / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D015415:Biomarkers