title: Hematological Issues in Liver Disease.
abstract: Acute and chronic liver failure are associated with numerous alterations in different features of the coagulation system. Consequently, there is widespread confusion regarding the potential for both bleeding and thrombosis in patients with liver disease. The risk of bleeding is related to the hemodynamic changes in portal pressures and venous congestion whereas the thrombotic risk stems from changes in the coagulation system. Antithrombotic prophylaxis and treatment of patients with hemorrhage and thrombosis requires careful assessment, interpretation of laboratory workup, and attention to coexistent morbidities. A framework for the management of these conditions is presented for clinicians.
authors.affiliation: Critical Care Medicine, St. Agnes Hospital, 900 South Caton Avenue, Box 062, Baltimore, MD 21229, USA. Electronic address: mgallison@gmail.com.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Allison
authors.affiliation: Medical Intensive Care Unit, Division of Pulmonary and Critical Care, University of Maryland School of Medicine, 110 South Paca Street, 2nd Floor, Baltimore, MD 21201, USA.
authors.forename: Carl B
authors.initials: CB
authors.lastname: Shanholtz
authors.affiliation: Interventional Pulmonary Program, Division of Pulmonary and Critical Care, University of Maryland School of Medicine, 110 South Paca Street, 2nd Floor, Baltimore, MD 21201, USA.
authors.forename: Ashutosh
authors.initials: A
authors.lastname: Sachdeva
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D001778:Blood Coagulation Disorders / Q000097:blood / Q000175:diagnosis* / Q000209:etiology*; D004211:Disseminated Intravascular Coagulation / Q000209:etiology; D006470:Hemorrhage / Q000209:etiology / Q000628:therapy*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000503:physiopathology; D017114:Liver Failure, Acute / Q000150:complications* / Q000503:physiopathology; D013927:Thrombosis / Q000209:etiology / Q000517:prevention & control / Q000628:therapy*
chemical_list: D000925:Anticoagulants
keywords: Acute liver failure; Anticoagulation; Cirrhosis; Coagulopathy; Thrombocytopenia; Thrombosis