title: Soluble CD93 as a Novel Biomarker in Asthma Exacerbation.
abstract: Asthma research is shifting from studying symptoms and lung functions to the narrow-focus cellular profiles protein analysis, biomarkers, and genetic markers. The transmembrane glycoprotein CD93 is involved in endothelial cell migration, angiogenesis, leukocytes extravasation, apoptosis, innate immunity and inflammation. Relationships between the serum level of soluble CD93 (sCD93) and acute myocardial infarction/premature MI/inflammatory arthritis/skin sclerosis have recently been reported. We hypothesized that sCD93 would be elevated during the acute phase of asthma. We measured the serum level of sCD93 in 57 patients with asthma exacerbation and 57 age-and gender-matched healthy controls. Additionally, sCD93 was reassessed at the time of discharge from the hospital. Clinical characteristics and peak expiratory flow (PEF) of the patients were assessed. The primary outcome was the comparison of serum level of sCD93 between asthmatics and healthy subjects. The sCD93 values ranged from 128 to 789 ng/mL in asthmatics (345.83±115.81) and from 31 to 289 ng/mL in control subjects (169.46±62.43). The difference between the 2 groups was statistically significant (P<0.001). The association between sCD93 and asthma remained significant after adjusting for age, sex, and BMI. The differences between asthmatics and controls remained significant on the last day of hospital stay. The association between sCD93 and PEF was not significant. In conclusion, the serum level of soluble CD93 is increased in patients with asthma exacerbation. It also showed that serum levels of sCD93 decreased with treatment of asthma attack. The clinical usefulness of determination of sCD93 as a biomarker of asthma requires further studies.
authors.affiliation: Internal Medicine Department, Medical Faculty, Kurdistan University of Medical Sciences, Sanandaj, Iran. naseh.sigari@muk.ac.ir.
authors.forename: Naseh
authors.identifier: http://orcid.org/0000-0002-5098-1877
authors.initials: N
authors.lastname: Sigari
authors.affiliation: Kurdistan Cellular & Molecular Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Jalili
authors.affiliation: Internal Medicine Department, Kurdistan University of Medical Sciences, Sanandaj, Iran.
authors.forename: Laili
authors.initials: L
authors.lastname: Mahdawi
authors.affiliation: Department of Epidemiology and Biostatistics, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
authors.forename: Ebrahim
authors.initials: E
authors.lastname: Ghaderi
authors.affiliation: Pediatrics Department, Medical Faculty,Kurdistan University of Medical Sciences, Sanandaj, Iran.
authors.forename: Mohammadi
authors.initials: M
authors.lastname: Shilan
keywords: Asthma; CD93; biomarker