title: Photosensitizer anchored gold nanorods for targeted combinational photothermal and photodynamic therapy.
abstract: Silylated zinc phthalocyanine (ZnPc) was anchored onto silica-coated gold nanorods (AuNR) with retained local surface plasmon resonance (LSPR). Independent LSPR and singlet oxygen production of anchored ZnPc enhance the photothermal and photodynamic efficacy of the obtained AuNR-Si-ZnPc under NIR light excitation. AuNR-Si-ZnPc was further grafted with hyaluronic acid (HA). Since HA has selective targeting capability to CD44 antigens, the final hybrid could target cancer cells directly for synergistic photothermal and photodynamic therapy.
authors.affiliation: Interdisciplinary Graduate School, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore and Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, 637371, Singapore. zhaoyanli@ntu.edu.sg and School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore. assubbu@ntu.edu.sg.
authors.forename: Huijun Phoebe
authors.initials: HP
authors.lastname: Tham
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, 637371, Singapore. zhaoyanli@ntu.edu.sg.
authors.forename: Hongzhong
authors.initials: H
authors.lastname: Chen
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, 637371, Singapore. zhaoyanli@ntu.edu.sg.
authors.forename: Yu Hui
authors.initials: YH
authors.lastname: Tan
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, 637371, Singapore. zhaoyanli@ntu.edu.sg.
authors.forename: Qiuyu
authors.initials: Q
authors.lastname: Qu
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, 637371, Singapore. zhaoyanli@ntu.edu.sg.
authors.forename: Sivaramapanicker
authors.initials: S
authors.lastname: Sreejith
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, 637371, Singapore. zhaoyanli@ntu.edu.sg.
authors.forename: Lingzhi
authors.initials: L
authors.lastname: Zhao
authors.affiliation: School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore. assubbu@ntu.edu.sg.
authors.forename: Subbu S
authors.initials: SS
authors.lastname: Venkatraman
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, 637371, Singapore. zhaoyanli@ntu.edu.sg and School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore. assubbu@ntu.edu.sg.
authors.forename: Yanli
authors.initials: Y
authors.lastname: Zhao