title: Assessment of the role of serum ischemia-modified albumin in obstructive sleep apnea in comparison with interleukin-6.
abstract: OBJECTIVE
  There is limited and contradictory information regarding the role of serum ischemia-modified albumin (IMA) in obstructive sleep apnea (OSA). In this study we examine the effects of OSA and obesity on IMA and interleukin-6 (IL-6), and detect whether IMA and IL-6 may be potential biomarkers in OSA.
  
  
  METHODS
  Fifty-one males who underwent all night polysomnography test were included into the study. Body-mass index (BMI) and apnea-hypopnea index (AHI) of all patients were determined. Serum IMA and IL-6 levels, erythrocyte sedimentation rate (ESR), complete blood count, routine blood biochemistry and thyroid function tests were performed.
  
  
  RESULTS
  Mean IMA [0.36 (± 0.04) U/ml, 0.89 (± 0.15) U/ml], mean IL-6 [1.01 (± 0.19) pg/ml, 2.02 (± 1.19) pg/ml] and mean ESR [4.14 (± 2.5) mm/h, 14.35 (± 13.7) mm/h] levels showed significant difference between non-OSA and OSA groups (P = 0.005, P < 0.001, P < 0.001, respectively). Sensitivity of IMA in distinction of non-OSA/OSA was equal to IL-6 and higher than ESR. IMA was also a stronger predictive factor than IL-6 and ESR in the evaluation of OSA groups (severe/mild/moderate OSA and non-OSA). IMA was the sole distinctive biomarker in assessment of obese and non-obese cases. IMA correlated with IL-6, AHI and ESR.
  
  
  CONCLUSIONS
  Serum IMA may be a valuable oxidative stress indicator for OSA and could act as a better biomarker than IL-6 for reflecting the presence and the severity of OSA.
authors.affiliation: a Department of Chest Diseases , Gulhane Military Medical Faculty , Ankara , Turkey.
authors.forename: Deniz
authors.initials: D
authors.lastname: Dogan
authors.affiliation: b Department of Intensive Care , Gulhane Military Medical Faculty , Ankara , Turkey.
authors.forename: Nesrin
authors.initials: N
authors.lastname: Ocal
authors.affiliation: c Department of Chest Diseases , Isparta Military Hospital , Isparta , Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Aydogan
authors.affiliation: a Department of Chest Diseases , Gulhane Military Medical Faculty , Ankara , Turkey.
authors.forename: Canturk
authors.initials: C
authors.lastname: Tasci
authors.affiliation: a Department of Chest Diseases , Gulhane Military Medical Faculty , Ankara , Turkey.
authors.forename: Yakup
authors.initials: Y
authors.lastname: Arslan
authors.affiliation: d Department of Biochemistry , Gulhane Military Medical Faculty , Ankara , Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Tapan
authors.affiliation: e Department of Psychiatry , Gulhane Military Medical Faculty , Ankara , Turkey.
authors.forename: Sinan
authors.initials: S
authors.lastname: Yetkin
authors.affiliation: a Department of Chest Diseases , Gulhane Military Medical Faculty , Ankara , Turkey.
authors.forename: Hayati
authors.initials: H
authors.lastname: Bilgic
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001772:Blood Cell Count; D001799:Blood Sedimentation; D015992:Body Mass Index; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000453:epidemiology; D017286:Polysomnography; D012680:Sensitivity and Specificity; D012709:Serum Albumin; D000075462:Serum Albumin, Human; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000453:epidemiology; D013960:Thyroid Function Tests
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D012709:Serum Albumin; C561522:ischemia-modified albumin; D000075462:Serum Albumin, Human
keywords: Biomarker; interleukin-6; ischemia-modified albumin; obesity; sleep apnea