title: Diurnal variation in the control of ventilation in response to rising body temperature during exercise in the heat.
abstract: We investigated whether heat-induced hyperventilation during exercise is affected by time of day, as diurnal variation leads to higher core temperatures in the evening. Nineteen male subjects were divided into two experiments (protocol 1, n = 10 and protocol 2, n = 9). In protocol 1, subjects performed cycle exercise at 50% peak oxygen uptake in the heat (37°C and 50% RH) in the morning (0600) and evening (1800). Results showed that baseline resting and exercising esophageal temperature (Tes) were significantly (0.5°C) higher in the evening than morning. Minute ventilation (V̇e) increased from 54.3 ± 7.9 and 54.9 ± 6.8 l/min at 10 min to 71.4 ± 8.1 and 76.5 ± 11.8 l/min at 48.5 min in the morning and evening, respectively (both P < 0.01). Time of day had no effect on V̇e (P = 0.44). When V̇e as the output response was plotted against Tes as thermal input, the Tes threshold for increases in V̇e was higher in the evening than morning (37.2 ± 0.7 vs. 36.6 ± 0.6°C, P = 0.009), indicating the ventilatory response to the same core temperature is smaller in the evening. In protocol 2, the circadian rhythm-related higher resting Tes seen in the evening was adjusted down to the same temperature seen in the morning by immersing the subject in cold water. Importantly, the time course of changes in V̇e during exercise were smaller in the evening, but the threshold for V̇e remained higher in the evening than morning (P < 0.001). Collectively, those results suggest that time of day has no effect on time course hyperventilation during exercise in the heat, despite the higher core temperatures in the evening. This is likely due to diurnal variation in the control of ventilation in response to rising core temperature.
authors.affiliation: Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba City, Ibaraki, Japan; Department of Health Sciences, Prefectural University of Hiroshima, Hiroshima, Japan; and.
authors.forename: Bun
authors.initials: B
authors.lastname: Tsuji
authors.affiliation: Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba City, Ibaraki, Japan;
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Honda
authors.affiliation: Faculty of Human Development, Kobe University, Kobe, Japan.
authors.forename: Narihiko
authors.initials: N
authors.lastname: Kondo
authors.affiliation: Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba City, Ibaraki, Japan; nisiyasu@taiiku.tsukuba.ac.jp.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nishiyasu
mesh_terms: D001831:Body Temperature / Q000502:physiology*; D001833:Body Temperature Regulation / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology*; D017753:Ecosystem; D015444:Exercise / Q000502:physiology*; D018869:Heat-Shock Response / Q000502:physiology*; D006801:Humans; D008297:Male; D010101:Oxygen Consumption / Q000502:physiology; D012123:Pulmonary Ventilation / Q000502:physiology*; D015656:Respiratory Mechanics / Q000502:physiology; D056152:Respiratory Rate / Q000502:physiology; D055815:Young Adult
keywords: circadian rhythm; hyperthermia; hyperventilation; thermoregulation