title: Drug-Coated Balloons for Infrainguinal Peripheral Artery Disease.
abstract: Revascularization of infrainguinal peripheral artery disease has traditionally been accomplished via percutaneous transluminal angioplasty. However, long-term results have been hampered by high rates of restenosis. Along with the advent of stents, paclitaxel-coated balloons are an emerging therapeutic option for the invasive management of infrainguinal peripheral artery disease. Paclitaxel has been successful in inhibiting neointimal hyperplasia, the main mechanism for in-stent restenosis. Technological advances have facilitated the development of paclitaxel-coated balloons, which show promise in early trials for femoropopliteal stenosis relative to uncoated balloons. For infrapopliteal stenoses, the data remain scant and conflicted. Therefore, large-scale randomized clinical trials with long-term follow-up evaluating safety and effectiveness between various strategies need to be performed to determine the optimal invasive management strategy for infrainguinal peripheral artery disease.
authors.affiliation: Division of Cardiology, UCLA Medical Center, 100 Medical Plaza Suite 630, Los Angeles, CA 90095 USA. mslee@mednet.ucla.edu.
authors.forename: Sanjum S
authors.initials: SS
authors.lastname: Sethi
authors.forename: Michael S
authors.initials: MS
authors.lastname: Lee
mesh_terms: D017130:Angioplasty / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D020099:Coated Materials, Biocompatible / Q000494:pharmacology; D003251:Constriction, Pathologic / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D054855:Drug-Eluting Stents; D005263:Femoral Artery / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D006965:Hyperplasia; D000069451:Long Term Adverse Effects / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D058426:Neointima / Q000473:pathology*; D017239:Paclitaxel / Q000494:pharmacology*; D058729:Peripheral Arterial Disease / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery; D011150:Popliteal Artery / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery; D014654:Vascular Patency
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D020099:Coated Materials, Biocompatible; D017239:Paclitaxel