title: Stimuli-responsive HBPS-g-PDMAEMA and its application as nanocarrier in loading hydrophobic molecules.
abstract: The topic of stimuli-responsive nanocarriers for loading guest molecules is dynamic. It has been widely studied in applications including drug controlled release, smart sensing, catalysis, and modeling. In this paper, a graft copolymer (hyperbranched polystyrene)-g-poly[2-(dimethylamino)ethyl methacrylate] (HBPS-g-PDMAEMA) was synthesized and characterized by (1)H NMR and GPC. It was observed that the star-like HBPS-g-PDMAEMA formed aggregates in aqueous solution. The influence of polymer concentration, ionic strength and pH value on the aggregates in aqueous solution was investigated by using UV-vis spectroscopy and DLS analysis. The results showed that size of aggregates was affected by a corresponding stimulus. In addition, the loading ability of HBPS-g-PDMAEMA aggregates was investigated by using pyrene or Nile red as the model guest molecules by using UV-vis and fluorescence spectroscopy. The results showed that HBPS-g-PDMAEMA aggregates were capable to encapsulate small hydrophobic molecules. These newly prepared HBPS-g-PDMAEMA nanocarriers might be used in, e.g., medicine or catalysis.
authors.affiliation: State Key Laboratory of Chemical Engineering College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, China.
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Chemical Engineering College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Chemical Engineering College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, China.
authors.forename: Haojie
authors.initials: H
authors.lastname: Yu
authors.affiliation: State Key Laboratory of Chemical Engineering College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, China.
authors.lastname: Zain-Ul-Abdin
authors.affiliation: State Key Laboratory of Chemical Engineering College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, China.
authors.forename: Ruoli
authors.initials: R
authors.lastname: Sun
authors.affiliation: State Key Laboratory of Chemical Engineering College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, China.
authors.forename: Guanghui
authors.initials: G
authors.lastname: Jing
authors.affiliation: State Key Laboratory of Chemical Engineering College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, China.
authors.forename: Rongbai
authors.initials: R
authors.lastname: Tong
authors.affiliation: State Key Laboratory of Chemical Engineering College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Deng
keywords: amphiphilic polymer; hyperbranched polystyrene; phase transition; poly[2-(dimethylamino)ethyl methacrylate] (PDMAEMA); stimuli-responsive nanocarriers