title: The Effect of Zinc Supplementation on Expressed Levels of Peroxisome Proliferator-Activated Receptor Gamma and Glucose Transporter Type 1 Genes in Newborns of Women with Gestational Diabetes Mellitus.
abstract: The current study was designed to determine the beneficial effects of zinc supplementation on expressed levels of peroxisome proliferator-activated receptor gamma (PPAR-γ) and glucose transporter type 1 (GLUT1) genes in newborns of women with gestational diabetes mellitus (GDM). This randomized, double-blind, placebo-controlled clinical trial was performed among 40 women with GDM. Patients were randomly allocated to intake either 233 mg zinc gluconate (containing 30 mg zinc) (n = 20) or a placebo (n = 20) for 6 weeks. PPAR-γ and GLUT1 mRNA levels were quantified in umbilical cord blood of newborns of women with GDM. After 6 weeks of intervention, the change in serum zinc levels was greater in women consuming zinc than in the placebo group (+11.1 ± 13.4 vs. -4.8 ± 17.3 mg/dL, P = 0.002). Quantitative results of RT-PCR demonstrated that compared with the placebo, zinc supplementation resulted in a significant increase of expressed levels of PPAR-γ mRNA (P < 0.001) and GLUT1 mRNA (P < 0.001) in umbilical cord blood of newborns of women with GDM. Taken together, the current study demonstrated that zinc supplementation for 6 weeks among GDM women increased the mRNA levels of PPAR-γ and GLUT1 in their newborns compared with the placebo group.
authors.affiliation: Department of Biology, Ashkezar Branch, Islamic Azad University, Ashkezar, Yazd, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Heidarzadeh
authors.affiliation: Department of Gynecology and Obstetrics, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran. dr_samimi.2007@yahoo.com.
authors.forename: Mansooreh
authors.initials: M
authors.lastname: Samimi
authors.affiliation: Department of Biology, Ashkezar Branch, Islamic Azad University, Ashkezar, Yazd, Iran.
authors.forename: Seyed Morteza
authors.initials: SM
authors.lastname: Seifati
authors.affiliation: Medical Biotechnology Research Center, Ashkezar Branch, Islamic Azad University, Ashkezar, Yazd, Iran.
authors.forename: Mahmood Dehghani
authors.initials: MD
authors.lastname: Ashkezari
authors.affiliation: Department of Gynecology and Obstetrics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.|Department of Gynecology and Obstetrics, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran.
authors.forename: Shahnaz
authors.initials: S
authors.lastname: Ahmadi
authors.affiliation: Department of Gynecology and Obstetrics, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
authors.forename: Samaneh
authors.initials: S
authors.lastname: Mahmoodi
authors.affiliation: Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.
authors.forename: Esmat
authors.initials: E
authors.lastname: Aghadavod
authors.affiliation: Department of Gynecology and Obstetrics, Endocrinology and Metabolism Research Center, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
authors.forename: Mehri
authors.initials: M
authors.lastname: Jamilian
authors.affiliation: Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran. asemi_r@yahoo.com.|Present address: Department of Nutrition, Kashan University of Medical Sciences, Kashan, Iran. asemi_r@yahoo.com.
authors.forename: Zatollah
authors.initials: Z
authors.lastname: Asemi
mesh_terms: D000293:Adolescent; D000328:Adult; D016640:Diabetes, Gestational / Q000097:blood*; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects*; D005942:Gluconates / Q000008:administration & dosage / Q000493:pharmacokinetics; D051272:Glucose Transporter Type 1 / Q000096:biosynthesis*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D047495:PPAR gamma / Q000096:biosynthesis*; D011247:Pregnancy; D015032:Zinc / Q000008:administration & dosage / Q000493:pharmacokinetics
chemical_list: D005942:Gluconates; D051272:Glucose Transporter Type 1; D047495:PPAR gamma; C495677:SLC2A1 protein, human; D015032:Zinc; C030691:gluconic acid
keywords: Gestational diabetes; Glucose transporter type 1; Peroxisome proliferator-activated receptor gamma; Supplementation; Zinc