title: No Evidence of Dengue Virus Infections in Several Species of Bats Captured in Central and Southern Mexico.
abstract: Bats are reservoirs for viruses with zoonotic potential in the Americas, and scattered evidence exists suggesting that bats may act as reservoirs for dengue virus (DENV). To explore further the role of bats as part of DENV sylvatic cycles, 240 bats of 18 species were captured in 2 states of Mexico with contrasting ecological characteristics but concurrent DENV activity in humans. RT-PCR analysis of RNA extracted from liver or spleen tissue from de bats failed to show evidence for the presence of DENV nucleic acids in these organs. In addition, plasma assayed by plaque reduction neutralization test showed no evidence of neutralizing anti-DENV antibodies. These results suggest that American bats may not be reservoirs or amplification host for DENV infection.
authors.affiliation: Department of infectomics and Molecular Pathogenesis, Center for Research and Advanced Studies (CINVESTAV-IPN), México City, Mexico.
authors.forename: S
authors.initials: S
authors.lastname: Cabrera-Romo
authors.affiliation: Regional Center for Vector Control, Jojutla, Mexico.
authors.forename: C
authors.initials: C
authors.lastname: Max Ramirez
authors.affiliation: Center for Research on Infectious Diseases (CISEI), National Institute of Public Health, (INSP) Cuernavaca, Mexico.
authors.forename: B
authors.initials: B
authors.lastname: Recio-Tótoro
authors.affiliation: Veterinary Clinic, Campeche, Mexico.
authors.forename: J
authors.initials: J
authors.lastname: Tolentino-Chi
authors.affiliation: Center for Research on Infectious Diseases (CISEI), National Institute of Public Health, (INSP) Cuernavaca, Mexico.
authors.forename: H
authors.initials: H
authors.lastname: Lanz
authors.affiliation: Department of infectomics and Molecular Pathogenesis, Center for Research and Advanced Studies (CINVESTAV-IPN), México City, Mexico.
authors.forename: R M
authors.initials: RM
authors.lastname: Del Ángel
authors.affiliation: Institute of Biology, Universidad Nacional Autónoma de México, Mexico City, Mexico.
authors.forename: V
authors.initials: V
authors.lastname: Sánchez-Cordero
authors.affiliation: Institute of Biology, Universidad Nacional Autónoma de México, Mexico City, Mexico.
authors.forename: Á
authors.initials: Á
authors.lastname: Rodríguez-Moreno
authors.affiliation: Department of infectomics and Molecular Pathogenesis, Center for Research and Advanced Studies (CINVESTAV-IPN), México City, Mexico.
authors.forename: J E
authors.initials: JE
authors.lastname: Ludert
mesh_terms: D000818:Animals; D002685:Chiroptera / Q000821:virology*; D003715:Dengue / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D003716:Dengue Virus / Q000302:isolation & purification*; D004197:Disease Reservoirs / Q000821:virology; D008099:Liver / Q000821:virology; D008800:Mexico / Q000453:epidemiology; D013154:Spleen / Q000821:virology; D015047:Zoonoses
keywords: Dengue virus; Mexico; bats; dengue sylvatic cycle