title: Circulating miR-30 is related to carotid artery atherosclerosis.
abstract: OBJECTIVE
  The aim of this study is to evaluate the relationship of miR-30 with office and ambulatory blood pressure parameters and carotid intima-media thickness (CIMT) in patients with hypertension and healthy controls.
  
  
  METHODS
  We assessed the expression level of miR-30 in 40 patients with essential hypertension and 40 healthy individuals. All patients underwent carotid artery ultrasonography, and office and ambulatory blood pressure monitoring. Quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) was used to evaluate the expression level of selected miR-30. The miR-30 expression level correlation between blood pressure parameters and CIMT was assessed using the Spearman correlation coefficient. Multiple logistic regression analysis was performed to assess independent association between miR-30 expression level and CIMT.
  
  
  RESULTS
  We observed lower expression level of miR-30 (26.01 ± 2.40 vs. 28.26 ± 1.28; p < 0.001) in hypertensive patients compared with healthy control individuals, as well as in increased CIMT group compared with normal CIMT group (25.09 ± 1.84 vs. 27.81 ± 2.37; p < 0.001). miR-30 expression level showed significant negative correlation with 24 h mean SBP (r = -0.51, p < 0.001), 24 h mean DBP(r = -0.316, p = 0.004), office SBP(r = -0.502, p < 0.001), office DBP (r = -0.205, p = 0.068), and CIMT (r = -0.578, p < 0.001), respectively. The odds ratio for CIMT was 0.519 (B = -0.748, CI 95% 0.278, 0.806; p = 0.006).
  
  
  CONCLUSIONS
  Our study suggests that circulating miR-30 might be used as a biomarker for atherosclerosis in essential hypertensive patients.
authors.affiliation: a Department of Cardiology , Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Disease, Guangdong General Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology , Guangzhou , China.
authors.forename: Yuqing
authors.initials: Y
authors.lastname: Huang
authors.affiliation: a Department of Cardiology , Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Disease, Guangdong General Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology , Guangzhou , China.
authors.forename: Jiyan
authors.initials: J
authors.lastname: Chen
authors.affiliation: a Department of Cardiology , Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Disease, Guangdong General Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology , Guangzhou , China.
authors.forename: Yingling
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: a Department of Cardiology , Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Disease, Guangdong General Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology , Guangzhou , China.
authors.forename: Xueju
authors.initials: X
authors.lastname: Yu
authors.affiliation: a Department of Cardiology , Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Disease, Guangdong General Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology , Guangzhou , China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Huang
authors.affiliation: a Department of Cardiology , Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Disease, Guangdong General Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology , Guangzhou , China.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: a Department of Cardiology , Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Disease, Guangdong General Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology , Guangzhou , China.
authors.forename: Yingqing
authors.initials: Y
authors.lastname: Feng
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D001795:Blood Pressure Determination; D018660:Blood Pressure Monitoring, Ambulatory; D002340:Carotid Artery Diseases / Q000209:etiology*; D017536:Carotid Artery, Common; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D000075222:Essential Hypertension; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D035683:MicroRNAs / Q000378:metabolism / Q000502:physiology*; D008875:Middle Aged
chemical_list: C546086:MIRN30b microRNA, human; D035683:MicroRNAs
keywords: Atherosclerosis; carotid intima-media thickness; essential hypertension; miR-30