title: In Vivo Investigation of the Effectiveness of a Hyper-viscoelastic Model in Simulating Brain Retraction.
abstract: Intraoperative brain retraction leads to a misalignment between the intraoperative positions of the brain structures and their previous positions, as determined from preoperative images. In vitro swine brain sample uniaxial tests showed that the mechanical response of brain tissue to compression and extension could be described by the hyper-viscoelasticity theory. The brain retraction caused by the mechanical process is a combination of brain tissue compression and extension. In this paper, we first constructed a hyper-viscoelastic framework based on the extended finite element method (XFEM) to simulate intraoperative brain retraction. To explore its effectiveness, we then applied this framework to an in vivo brain retraction simulation. The simulation strictly followed the clinical scenario, in which seven swine were subjected to brain retraction. Our experimental results showed that the hyper-viscoelastic XFEM framework is capable of simulating intraoperative brain retraction and improving the navigation accuracy of an image-guided neurosurgery system (IGNS).
authors.affiliation: Digital Medical Research Center, School of Basic Medical Sciences, Fudan University, Shanghai, People's Republic of China.|Shanghai Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention, Fudan University, Shanghai, People's Republic of China.|Shanghai University of Medicine &Health Sciences, Shanghai, People's Republic of China.
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.affiliation: Digital Medical Research Center, School of Basic Medical Sciences, Fudan University, Shanghai, People's Republic of China.|Shanghai Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention, Fudan University, Shanghai, People's Republic of China.|Department of Medical Physics, Shanghai Proton and Heavy Ion Center, Shanghai, People's Republic of China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Digital Medical Research Center, School of Basic Medical Sciences, Fudan University, Shanghai, People's Republic of China.|Shanghai Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention, Fudan University, Shanghai, People's Republic of China.
authors.forename: Chenxi
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Digital Medical Research Center, School of Basic Medical Sciences, Fudan University, Shanghai, People's Republic of China.|Shanghai Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention, Fudan University, Shanghai, People's Republic of China.
authors.forename: Yong
authors.initials: Y
authors.lastname: An
authors.affiliation: Digital Medical Research Center, School of Basic Medical Sciences, Fudan University, Shanghai, People's Republic of China.|Shanghai Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention, Fudan University, Shanghai, People's Republic of China.
authors.forename: Zhijian
authors.initials: Z
authors.lastname: Song
mesh_terms: D000818:Animals; D001921:Brain / Q000503:physiopathology / Q000601:surgery; D004548:Elasticity; D008959:Models, Neurological; D019635:Neurosurgical Procedures / Q000009:adverse effects / Q000379:methods; D011183:Postoperative Complications / Q000503:physiopathology / Q000517:prevention & control; D025321:Surgery, Computer-Assisted / Q000009:adverse effects / Q000379:methods; D013552:Swine; D014783:Viscosity