title: Length Matters: MINDY Is a New Deubiquitinase Family that Preferentially Cleaves Long Polyubiquitin Chains.
abstract: Abdul Rehman and colleagues identify a sixth family of deubiquitinase enzymes that are highly conserved throughout eukaryotes and show a remarkable selectivity for cleaving extended Lys-48-linked polyubiquitin chains.
authors.affiliation: Department of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
authors.forename: Till
authors.initials: T
authors.lastname: Maurer
authors.affiliation: Departmant of Discovery Oncology, Genentech Inc., 1 DNA Way, South San Francisco, CA, 94080, USA; Department of Early Discovery Biochemistry, Genentech Inc., 1 DNA Way, South San Francisco, CA, 94080, USA. Electronic address: wertz.ingrid@gene.com.
authors.forename: Ingrid E
authors.initials: IE
authors.lastname: Wertz
mesh_terms: D000072017:Deubiquitinating Enzymes; D056890:Eukaryota; D006801:Humans; D025821:Polyubiquitin
chemical_list: D025821:Polyubiquitin; D000072017:Deubiquitinating Enzymes