title: Comparison of paroxetine and amitriptyline in the treatment of refractory globus pharyngeus.
abstract: BACKGROUND
  Clinical trials of antidepressants for treatment of globus are generally rare, let alone for refractory globus pharyngeus.
  
  
  OBJECTIVE
  To illustrate the efficacy and side-effects of antidepressants between paroxetine and amitriptyline for refractory globus patients.
  
  
  METHODS
  Refractory globus patients were randomized into paroxetine group; amitriptyline group and lansoprazole group for 6-week treatment. All the subjects were asked to complete the following questionnaires pre- and post-therapy: Glasgow Edinburgh Throat Scale (GETS), Pittsburgh Sleep Quality Index, Hamilton Rating Scale Anxiety/Depression and Medical outcome short-form 36. Treatment response was defined as a >50% reduction in the GETS score.
  
  
  RESULTS
  One hundred and forty-eight patients completed the study. After 6 week treatment, 71.7% of paroxetine group (33/46) were calculated as treatment response, significantly higher than that in amitriptyline group (46.2%, 24/52) and lansoprazole group (14.0%, 7/50). Compared with lansoprazole group or amitriptyline group, a more distinct improvement of emotional well-being, quality of life and quality of sleep were observed in paroxetine group after 6-week treatment.
  
  
  CONCLUSIONS
  Paroxetine therapy is more efficacious than empirical high-dose antisecretory treatment, or even the low-dose amitriptyline therapy in alleviating globus symptoms, and producing global improvements for refractory globus patients.
authors.affiliation: Department of Gastroenterology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong Province, China.
authors.forename: Dong-Yun
authors.initials: DY
authors.lastname: Chen
authors.affiliation: Department of Gastroenterology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong Province, China; Department of Gastroenterology, Guangzhou Nansha Central Hospital Affiliated to Guangzhou First People's Hospital, Guangzhou, Guangdong Province, China. Electronic address: 13925012853@139.com.
authors.forename: Lin
authors.initials: L
authors.lastname: Jia
authors.affiliation: Department of Gastroenterology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong Province, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Gu
authors.affiliation: Department of Gastroenterology, Guangzhou Nansha Central Hospital Affiliated to Guangzhou First People's Hospital, Guangzhou, Guangdong Province, China.
authors.forename: Shu-Man
authors.initials: SM
authors.lastname: Jiang
authors.affiliation: Department of Epidemiology, Guangzhou Nansha Central Hospital, Guangzhou, Guangdong Province, China.
authors.forename: Hai-Li
authors.initials: HL
authors.lastname: Xie
authors.affiliation: Department of Psychology, Guangzhou Nansha Central Hospital, Guangzhou, Guangdong Province, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Xu
mesh_terms: D000328:Adult; D000639:Amitriptyline / Q000008:administration & dosage* / Q000009:adverse effects; D000928:Antidepressive Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001007:Anxiety / Q000523:psychology; D002681:China; D003863:Depression / Q000523:psychology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D064747:Lansoprazole / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D017374:Paroxetine / Q000008:administration & dosage* / Q000009:adverse effects; D010608:Pharyngeal Diseases / Q000188:drug therapy* / Q000523:psychology*; D011446:Prospective Studies; D054328:Proton Pump Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D054328:Proton Pump Inhibitors; D064747:Lansoprazole; D000639:Amitriptyline; D017374:Paroxetine
keywords: Antidepressants; Global improvement; Psychological state; Refractory globus pharyngeus