title: [Study of the Effect of Cholecystokinin-Induced Acute Pancreatitis on the Free-Running Rhythm of Mouse].
abstract: The present paper reports the effect of pancreatitis induced by cholecystokinin (CCK) on free-running rhythm of locomotor activity of the ICR mice, and analyzes the interaction of inflammatory diseases and acute pancreatitis with circadian rhythm system. In the study, the mice were modeled under different phases of acute pancreatitis in DD status (Double Dark, constant dark condition). By comparing of the inflammatory status and the indicators of rhythm before and after modeling of the running wheel activity group and the rest group, it was observed that the rest group showed more possibility of inflammation than the activity group did in ICR mice model of acute pancreatitis. In the rest phase model, the extension of the period is particularly longer. The results presented indicated that CCK-induced acute pancreatitis impacted free activity rhythm of ICR mice. Also in a free running model under different phase, the inflammation severity was proved significantly different. This study provides possible clues for the research of the pathogenesis of acute pancreatitis severe tendency.
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Li
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Yang
authors.forename: Panpan
authors.initials: P
authors.lastname: Guo
authors.forename: Yanyou
authors.initials: Y
authors.lastname: Liu
authors.forename: Hongli
authors.initials: H
authors.lastname: Yan
authors.forename: Shuaizhen
authors.initials: S
authors.lastname: Li
authors.forename: Junwen
authors.initials: J
authors.lastname: Guan
mesh_terms: D000818:Animals; D002766:Cholecystokinin / Q000009:adverse effects; D002940:Circadian Rhythm; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity; D010195:Pancreatitis / Q000139:chemically induced / Q000503:physiopathology*
chemical_list: D002766:Cholecystokinin