title: Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway.
abstract: Coffee and tea, two of the most popular drinks around the world, share many in common from chemical components to beneficial effects on human health. One of their shared components, the polyphenols, most notably chlorogenic acid (CGA), was supposed to account for many of the beneficial effects on ameliorating diseases occurred accompanying people aging, such as the antioxidant effect and against diabetes and cardiovascular disease. CGA is also present in many traditional Chinese medicines. However, the mechanism of these effects was vague. The aging signaling pathways were conservative from yeast and worms to mammals. So, we tested if CGA had an effect on aging in Caenorhabditis elegans. We found that CGA could extend the lifespan of C. elegans by up to 20.1%, delay the age-related decline of body movement, and improve stress resistance. We conducted genetic analysis with a series of worm mutants and found that CGA could extend the lifespan of the mutants of eat-2, glp-1, and isp-1, but not of daf-2, pdk-1, akt-1, akt-2, sgk-1, and clk-1. CGA could activate the FOXO transcription factors DAF-16, HSF-1, SKN-1, and HIF-1, but not SIR-2.1. Taken together, CGA might extend the lifespan of C. elegans mainly via DAF-16 in insulin/IGF-1 signaling pathway.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan, China.|University of Chinese Academy of Sciences, Beijing, China.
authors.forename: Shan-Qing
authors.initials: SQ
authors.lastname: Zheng
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan, China.|University of Chinese Academy of Sciences, Beijing, China.
authors.forename: Xiao-Bing
authors.initials: XB
authors.lastname: Huang
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan, China.|University of Chinese Academy of Sciences, Beijing, China.
authors.forename: Ti-Kun
authors.initials: TK
authors.lastname: Xing
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan, China.|University of Chinese Academy of Sciences, Beijing, China.
authors.forename: Ai-Jun
authors.initials: AJ
authors.lastname: Ding
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan, China.
authors.forename: Gui-Sheng
authors.initials: GS
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan, China.
authors.forename: Huai-Rong
authors.initials: HR
authors.lastname: Luo
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000187:drug effects* / Q000502:physiology*; D002726:Chlorogenic Acid / Q000494:pharmacology*; D007328:Insulin / Q000502:physiology*; D007334:Insulin-Like Growth Factor I / Q000187:drug effects* / Q000502:physiology*; D008136:Longevity / Q000187:drug effects*; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D007328:Insulin; D002726:Chlorogenic Acid; D007334:Insulin-Like Growth Factor I
keywords: Caenorhabditis elegans; Chlorogenic acid; DAF-16/FOXO; Longevity; Stress resistance