title: [Clinical characteristics of histoplamosis in 8 patients: case report and literature review].
abstract: To explore the clinical characteristics, imaging manifestation, diagnosis and treatment for histoplasmosis and to improve therapeutic level, we retrospectively analyzed the clinical data of 8 patients with biopsy-confirmed histoplasmosis from 2004 to 2014 in the Second Xiangya Hospital of Central South University and reviewed relevant literatures. The main clinical symptoms of histoplasmosis included fever, cough, expectoration, chest pain, blood-stained sputum, lymphadenectasis, etc. The major lung imaging features were mass, node or pneumonia-like performance. No case was diagnosed as histoplasimosis firstly. Four patients whose imaging manifestations were focal pulmonary lesion received lobectomy of lung lesions or wedge resection. Clinical and imaging manifestations in 3 patients, who treated with amphotericin B or its liposomal, itraconazole or fluconazole, were improved. The clinical symptoms and imaging findings of histoplasmosis are nonspecific. It is easy for the physicians to misdiagnose histoplasmosis as bacterial infection, lung cancer, tuberculosis lymphoma, etc. Therefore, it is significant and necessary to carry out multiple biopsies combined with multiple etiological examinations for patients with difficult diagnosis.
authors.affiliation: Department of Respiratory Medicine, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Pathology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Songqing
authors.initials: S
authors.lastname: Fan
authors.affiliation: Department of Pathology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Qingchun
authors.initials: Q
authors.lastname: Liang
authors.affiliation: Department of Respiratory Medicine, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Yating
authors.initials: Y
authors.lastname: Peng
authors.affiliation: Department of Respiratory Medicine, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Zong
authors.affiliation: Department of Respiratory Medicine, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Ruoyun
authors.initials: R
authors.lastname: Ouyang
mesh_terms: D000666:Amphotericin B; D001706:Biopsy; D003951:Diagnostic Errors; D006660:Histoplasmosis; D006801:Humans; D008168:Lung; D008175:Lung Neoplasms; D011014:Pneumonia; D012189:Retrospective Studies; D013183:Sputum
chemical_list: D000666:Amphotericin B