title: Evaluating the Prevalence of the Epidermal Growth Factor Receptor in Transitional Cell Carcinoma of Bladder and its Relationship With Other Prognostic Factors.
abstract: BACKGROUND
  The most common malignancy in the urinary system has been bladder cancer and the most predominant histologic subtype has been transitional cell carcinoma (TCC). There were many molecular risk factors, related with poor prognosis. One of these factors was expression of epidermal growth factor receptor (EGFR).
  
  
  OBJECTIVE
  The aim of this study was to evaluate the prevalence of the epidermal growth factor receptor in transitional cell carcinoma of bladder and its relationship with other prognostic factors.
  
  
  METHODS
  This analytic descriptive study has performed with 61 patients with TCC of bladder after radical cystectomy whom have been hospitalized in Labbafinejad hospital in Tehran, Iran between 2007 and 2010. We have used Chi-square and t-test to analyze our data samples.
  
  
  RESULTS
  Records of 61 patients have studied. Fifty three of the total samples were positive for EGFR expression (86.9%). Fifty samples of these fifty-three belonged to men and three others were women's samples (P = 0.46). Among the group with EGFR expression the results were as follows: 25 patients (47.2%) were 60 years old or less and 28 patients (52.8%) were older than 60 (P = 0.023), 16 patients (30.2%) had invasion to lamina properia, and the rest of them had invasion to deeper layers (P = 0.56). For most patients we could not determine the invasion of tumoral cells into the lymph nodes (Nx) (P = 0.067). Thirty four patients (64.2%) had not lymphovascular invasion (P = 0.44) and in forty three of patients (81.1%), perineural invasion have not seen (P = 0.23). Finally, 36 patients (67.9%) were grade 3 (P = 0.27).
  
  
  CONCLUSIONS
  In this study we have concluded that most patients had EGFR positive expression. Also, except for the age, there was not any significant relation between expression of EGFR and the other prognostic factors such as, gender, invasion of the tumor into the layers, involving the lymph nodes, lymphovascular or perineural invasion, and grading.
authors.affiliation: Department of Pathology, Labbafinejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Parvin
authors.affiliation: Cancer Research Center, Shohada-e-Tajrish Hospital, Department of Radiation Oncology, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
authors.forename: Parto
authors.initials: P
authors.lastname: Sabet-Rasekh
authors.affiliation: Cancer Research Center, Shohada-e-Tajrish Hospital, Department of Radiation Oncology, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
authors.forename: Parastoo
authors.initials: P
authors.lastname: Hajian
authors.affiliation: Department of Pathology, Labbafinejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
authors.forename: Peyman
authors.initials: P
authors.lastname: Mohammadi Torbati
authors.affiliation: Cancer Research Center, Shohada-e-Tajrish Hospital, Department of Radiation Oncology, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
authors.forename: Parisa
authors.initials: P
authors.lastname: Sabet-Rasekh
authors.affiliation: Cancer Research Center, Shohada-e-Tajrish Hospital, Department of Radiation Oncology, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
authors.forename: Hamidreza
authors.initials: H
authors.lastname: Mirzaei
keywords: Epidermal Growth Factor Receptor; Prognostic Factors; Transitional Cell Carcinoma