title: [Venous Thromboembolism during the Cisplatin-based Adjuvant Chemotherapy;Report of a Case].
abstract: We report a case of venous thromboembolism during the cisplatin-based adjuvant chemotherapy. A 49-year-old woman who was undergone left lower lobectomy for the lung cancer received adjuvant chemotherapy of cisplatin + vinorelbine ditartrate regimen. On day 11 after starting the chemotherapy, she presented a left lower leg pain and readmitted. Computed tomography revealed a deep venous thrombosis of the left lower leg and peripheral pulmonary embolism. The symptom and thromboembolism were successfully treated by anticoagulant drug and thrombolytic therapy. Although cisplatin-based chemotherapy is a risk factor of venous thromboembolism in patients with advanced malignancy, it should be also recognized as a complication of the adjuvant chemotherapy after surgery.
authors.affiliation: Division of Thoracic Surgery, Fukuyama City Hospital, Fukuyama, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Yamada
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshioka
authors.forename: Masahiko
authors.initials: M
authors.lastname: Muro
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects*; D002945:Cisplatin / Q000009:adverse effects*; D057915:Drug Substitution; D004359:Drug Therapy, Combination; D004452:Echocardiography; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage; D000077425:Fondaparinux; D006801:Humans; D008175:Lung Neoplasms / Q000601:surgery*; D008875:Middle Aged; D011134:Polysaccharides / Q000008:administration & dosage; D011725:Pyridines / Q000008:administration & dosage; D013844:Thiazoles / Q000008:administration & dosage; D015912:Thrombolytic Therapy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage; D054556:Venous Thromboembolism / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000188:drug therapy*
chemical_list: D000925:Anticoagulants; D005343:Fibrinolytic Agents; D011134:Polysaccharides; D011725:Pyridines; D013844:Thiazoles; D014568:Urokinase-Type Plasminogen Activator; D000077425:Fondaparinux; C552171:edoxaban; D002945:Cisplatin