title: Neural substrates involved in anger induced by audio-visual film clips among patients with alcohol dependency.
abstract: BACKGROUND
  Very little is known about the neural circuitry underlying anger processing among alcoholics. The purpose of this study was to examine the altered brain activity of alcoholic individuals during transient anger emotion.
  
  
  METHODS
  Using functional magnetic resonance imaging (fMRI), 18 male patients diagnosed with alcohol dependence in an inpatient alcohol treatment facility and 16 social drinkers with similar demographics were scanned during the viewing of anger-provoking film clips.
  
  
  RESULTS
  While there was no significant difference in the level of experienced anger between alcohol-dependent patients and non-alcoholic controls, significantly greater activation was observed in the bilateral dorsal anterior cingulate cortex (dACC) and the right precentral gyrus among alcoholic patients compared to the normal controls.
  
  
  CONCLUSIONS
  In summary, specific brain regions were identified that are associated with anger among patients with alcohol dependency.
authors.affiliation: Department of Counseling Psychology, Hanyoung Theological University, 290-42 Kyoungin-ro, Guro-gu, Seoul, 152-717, Republic of Korea.
authors.forename: Mi-Sook
authors.initials: MS
authors.lastname: Park
authors.affiliation: Department of Physiology, Brain Korea PLUS Project for Medical Science, Brain Research Institute, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
authors.forename: Bae Hwan
authors.initials: BH
authors.lastname: Lee
authors.affiliation: Department of Psychology, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon, 305-764, Republic of Korea. jhsohn@cnu.ac.kr.
authors.forename: Jin-Hun
authors.initials: JH
authors.lastname: Sohn
mesh_terms: D000328:Adult; D000437:Alcoholism; D000786:Anger / Q000502:physiology*; D001921:Brain / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D014741:Video Recording
keywords: Alcohol dependency; Anger; Audio-visual film clips; fMRI