title: Programmed Nanoparticles for Tailoring the Detection of Inflammatory Bowel Diseases and Irritable Bowel Syndrome Disease via Breathprint.
abstract: Chemical sensors based on programmable molecularly modified gold nanoparticles are tailored for the detection and discrimination between the breathprint of irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD). The sensors are examined in both lab- and real-world clinical conditions. The results reveal a discriminative power accuracy of 81% between IBD and IBS and 75% between Crohn's and Colitis states.
authors.affiliation: Internal Medicine C and Gastroenterology Departments at Rambam Medical Center, Rappaport School of Medicine at Technion-Israel Institute of Technology, Haifa, 3109610, Israel.
authors.forename: Amir
authors.initials: A
authors.lastname: Karban
authors.affiliation: Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion-Israel Institute of Technology, Haifa, 3200003, Israel.
authors.forename: Morad K
authors.initials: MK
authors.lastname: Nakhleh
authors.affiliation: Department of Chemical Engineering, Complutense University of Madrid, Madrid, 28040, Spain.
authors.forename: John C
authors.initials: JC
authors.lastname: Cancilla
authors.affiliation: Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion-Israel Institute of Technology, Haifa, 3200003, Israel.
authors.forename: Rotem
authors.initials: R
authors.lastname: Vishinkin
authors.affiliation: Department of Gastroenterology at Bnai Zion Hospital, Rappaport School of Medicine at Technion-Israel Institute of Technology, Haifa, 31048, Israel.
authors.forename: Tova
authors.initials: T
authors.lastname: Rainis
authors.affiliation: Internal Medicine C and Gastroenterology Departments at Rambam Medical Center, Rappaport School of Medicine at Technion-Israel Institute of Technology, Haifa, 3109610, Israel.
authors.forename: Eduard
authors.initials: E
authors.lastname: Koifman
authors.affiliation: Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion-Israel Institute of Technology, Haifa, 3200003, Israel.
authors.forename: Raneen
authors.initials: R
authors.lastname: Jeries
authors.affiliation: Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion-Israel Institute of Technology, Haifa, 3200003, Israel.
authors.forename: Hodaya
authors.initials: H
authors.lastname: Ivgi
authors.affiliation: Department of Chemical Engineering, Complutense University of Madrid, Madrid, 28040, Spain.
authors.forename: Jose S
authors.initials: JS
authors.lastname: Torrecilla
authors.affiliation: Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion-Israel Institute of Technology, Haifa, 3200003, Israel. hhossam@technion.ac.il.
authors.forename: Hossam
authors.initials: H
authors.lastname: Haick
mesh_terms: D000328:Adult; D015374:Biosensing Techniques / Q000379:methods*; D001944:Breath Tests / Q000379:methods; D003424:Crohn Disease / Q000175:diagnosis* / Q000378:metabolism; D005260:Female; D006046:Gold / Q000737:chemistry*; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D008875:Middle Aged
chemical_list: D006046:Gold
keywords: breathprint; diagnosis; inflammatory bowel disease; irritable bowel syndrome; nanoparticles; sensors