title: Cutaneous Langerhans cell histiocytosis : The spectrum of a rare cutaneous neoplasia.
abstract: Langerhans cell histiocytosis (LCH) is a rare disorder that is now recognized as a true malignancy of dendritic Langerhans cells. Various somatic mutations have been discovered for BRAF and MAP kinases. The clinical variability is remarkable. A very rare variant is cutaneous LCH without internal organ manifestations. We present a case series of cutaneous LCH illustrating the spectrum of clinical symptoms, treatment, and disease course. Cutaneous LCH needs a careful investigation of possible internal involvement and a long follow-up since second malignancies may develop over time. Overtreatment should be avoided, since too-aggressive treatment will not improve the outcome.
authors.affiliation: Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Friedrichstr. 41, 01067, Dresden, Germany. uwollin@gmail.com.
authors.forename: Uwe
authors.initials: U
authors.lastname: Wollina
authors.affiliation: Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Friedrichstr. 41, 01067, Dresden, Germany.
authors.forename: Dana
authors.initials: D
authors.lastname: Langner
authors.affiliation: Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Friedrichstr. 41, 01067, Dresden, Germany.
authors.forename: Gesina
authors.initials: G
authors.lastname: Hansel
authors.affiliation: Institute for Pathology "Georg Schmorl", Academic Teaching Hospital Dresden-Friedrichstadt, Friedrichstr. 41, 01067, Dresden, Germany.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Schönlebe
mesh_terms: D000368:Aged; D001706:Biopsy; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000473:pathology / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008297:Male; D008875:Middle Aged; D012867:Skin; D012878:Skin Neoplasms / Q000473:pathology / Q000628:therapy
keywords: Histology; Langerhans cell histiocytosis; Mutations; Second malignancies; Treatment