title: Enhancement of Automaticity by Mechanical Stretch of the Isolated Guinea Pig Pulmonary Vein Myocardium.
abstract: The effects of mechanical stretch on the automaticity of the guinea pig isolated pulmonary vein preparations were studied in microelectrode experiments. The application of cumulative mechanical stretch to the preparations resulted in increases in the firing rate of spontaneous electrical activity in the myocardial layer. This effect was significantly inhibited by stretch-activated channel blockers such as gadolinium or streptomycin. These results suggest that acute mechanical stretch enhances the automaticity of the guinea pig pulmonary vein myocardium through the opening of the stretch-activated channels.
authors.affiliation: Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University.
authors.forename: Shogo
authors.initials: S
authors.lastname: Hamaguchi
authors.forename: Koh
authors.initials: K
authors.lastname: Hikita
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Tsuneoka
authors.forename: Iyuki
authors.initials: I
authors.lastname: Namekata
authors.forename: Hikaru
authors.initials: H
authors.lastname: Tanaka
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D005682:Gadolinium / Q000494:pharmacology; D006168:Guinea Pigs; D006321:Heart / Q000502:physiology; D066298:In Vitro Techniques; D011667:Pulmonary Veins / Q000502:physiology*; D013307:Streptomycin / Q000494:pharmacology; D013314:Stress, Mechanical
chemical_list: D005682:Gadolinium; D013307:Streptomycin