title: [Aortic valve calcification prevalence and association with coronary risk factors and atherosclerosis in Mexican population].
abstract: OBJECTIVE
  The prevalence of aortic valve calcification (AVC), strongly influenced by ethnicity, is unknown in Mexican population. The aim of this study was to investigate the prevalence of AVC and its associations with cardiovascular risk factors and coronary artery calcification (CAC), in Mexican subjects.
  
  
  METHODS
  In 1,267 subjects (53% women) without known coronary heart disease, aged 35 to 75 years, AVC and CAC were assessed by multidetector-computed tomography using the Agatston score. Cardiovascular risk factors were documented in all participants. The associations of AVC with CAC and risk factors were assessed by multivariable logistic regression analyses.
  
  
  RESULTS
  The overall prevalence of AVC and CAC was 19.89% and 26.5%, respectively. AVC and CAC increased with age and were found more frequently in men (25.5% and 37.1%, respectively) than in women (14.9% and 13.0%, respectively). AVC was observed in only 8.5% of subjects without CAC, while those with CAC 1-99, 100-399, and >400 Agatston units had AVC prevalences of 36.8%, 56.8%, and 84.0%, respectively. The multivariable logistic regression analyses, adjusted for age, gender, obesity, physical inactivity, hypertension, dyslipidemia and high insulin levels, showed that the presence of CAC (OR [CI95%]: 3.23 [2.26-4.60]), obesity (1.94 [1.35-2.79]), male gender (1.44 [1.01-2.05]) and age (1.08 [1.03-1.10]), were significant independent predictors of AVC.
  
  
  CONCLUSIONS
  Prevalence of AVC is high and significantly associated with atherosclerotic risk factors and CAC in this Mexican population.
authors.affiliation: Programa de Doctorado en Ciencias Médicas de la Universidad Nacional Autónoma de México, sede en el Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México.
authors.forename: Jorge
authors.initials: J
authors.lastname: Acuña-Valerio
authors.affiliation: Departamento de Cardiología, Hospital General San Juan de Dios, Ciudad de Guatemala, Guatemala.
authors.forename: Marco A
authors.initials: MA
authors.lastname: Rodas-Díaz
authors.affiliation: Servicio de Cardiología Intervencionista, Hospital Bite Médica, Ciudad de México, México.
authors.forename: Enrico
authors.initials: E
authors.lastname: Macias-Garrido
authors.affiliation: Departamento de Endocrinología, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México.
authors.forename: Rosalinda
authors.initials: R
authors.lastname: Posadas-Sánchez
authors.affiliation: Departamento de Endocrinología, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México.
authors.forename: Juan G
authors.initials: JG
authors.lastname: Juárez-Rojas
authors.affiliation: Departamento de Endocrinología, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México.
authors.forename: Aida X
authors.initials: AX
authors.lastname: Medina-Urrutia
authors.affiliation: Departamento de Endocrinología, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México.
authors.forename: Guillermo C
authors.initials: GC
authors.lastname: Cardoso-Saldaña
authors.affiliation: Departamento de Endocrinología, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México.
authors.forename: Esteban
authors.initials: E
authors.lastname: Joge-Galarza
authors.affiliation: Departamento de Endocrinología, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México.
authors.forename: Margarita
authors.initials: M
authors.lastname: Torres-Tamayo
authors.affiliation: Departamento de Biología Molecular, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México.
authors.forename: Gilberto
authors.initials: G
authors.lastname: Vargas-Alarcón
authors.affiliation: Departamento de Endocrinología, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México. Electronic address: cposadasr@yahoo.com.
authors.forename: Carlos
authors.initials: C
authors.lastname: Posadas-Romero
mesh_terms: D000328:Adult; D000368:Aged; D001021:Aortic Valve / Q000473:pathology*; D001024:Aortic Valve Stenosis / Q000150:complications* / Q000453:epidemiology*; D002114:Calcinosis / Q000150:complications* / Q000453:epidemiology*; D003324:Coronary Artery Disease / Q000150:complications* / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors
keywords: Aortic valve calcification; Calcificación arterial coronaria; Calcificación valvular aórtica; Cardiovascular disease; Cardiovascular risk factors; Coronary artery calcification; Enfermedad cardiovascular; Factores de riesgo coronario; Mexico; México