title: Association between lipoprotein(a) and nonalcoholic fatty liver disease among Korean adults.
abstract: BACKGROUND
  Lipoprotein(a) [Lp(a)] and nonalcoholic fatty liver disease (NAFLD) are risk factors for cardiovascular diseases. We investigated the relationship between Lp(a) concentrations and NAFLD among Korean adults.
  
  
  METHODS
  A total of 2242 nondiabetic subjects undergoing routine health screening examination were enrolled. Anthropometric and biochemical parameters, including Lp(a) were measured. NAFLD were assessed by ultrasonography. Adjusted Odds ratios for the presence of NAFLD according to Lp(a) tertiles were estimated using logistic regression.
  
  
  RESULTS
  Subjects were grouped according to the severity of NAFLD and Lp(a) concentrations. Lp(a) concentrations were decreased across the severity of NAFLD and the prevalence of NAFLD decreased with the Lp(a) tertiles. Compared with subjects in the lowest tertile of Lp(a), those in the highest tertile had higher total cholesterol and LDL-C concentrations and lower body mass index, blood pressure, fasting glucose, triglyceride, ALT, and HOMA-IR concentrations. In the logistic regression analysis after adjusting for multiple risk factors, the relationship between Lp(a) concentrations and the presence of NAFLD remained significant. However, this association was attenuated after adjusting for insulin resistance.
  
  
  CONCLUSIONS
  Lp(a) was inversely associated with the presence of NAFLD, but it was not an independent risk factor for NAFLD among Korean adults.
authors.affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Severance Institute for Vascular and Metabolic Research, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: Ji Sun
authors.initials: JS
authors.lastname: Nam
authors.affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: Sehee
authors.initials: S
authors.lastname: Jo
authors.affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Severance Institute for Vascular and Metabolic Research, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: Shinae
authors.initials: S
authors.lastname: Kang
authors.affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Severance Institute for Vascular and Metabolic Research, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: Chul Woo
authors.initials: CW
authors.lastname: Ahn
authors.affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: Kyung Rae
authors.initials: KR
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Severance Institute for Vascular and Metabolic Research, Yonsei University College of Medicine, Seoul, South Korea. Electronic address: pjs00@yuhs.ac.
authors.forename: Jong Suk
authors.initials: JS
authors.lastname: Park
mesh_terms: D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood*; D012044:Regression Analysis; D056910:Republic of Korea; D012307:Risk Factors
chemical_list: D008074:Lipoproteins
keywords: Insulin resistance; Lipoprotein(a); Nonalcoholic fatty liver disease