title: Protective role of apigenin in cisplatin-induced renal injury.
abstract: This study aimed to investigate the effects and molecular mechanisms of the effects of apigenin on cisplatin (CP)-induced kidney injury in mice. Apigenin was intraperitoneally administered for 3 consecutive days before CP treatment. We found that apigenin pretreatment significantly attenuated the damage to the kidneys and decreased the levels of serum creatinine, blood urea nitrogen (BUN), glutathione peroxidase (GSH-PX) and superoxide dismutase (SOD), which were increased by CP. Apigenin significantly decreased the levels of TNF-α, IL-1β and TGFβ in the kidneys. Additionally, apigenin inhibited the activations of CYP2E1, phospho-NF-κB p65 and phospho-P38 MAPK in CP-induced renal injury. These results suggest that the renoprotective effects of apigenin may be related to the suppressions of oxidative stress and inflammation in CP-induced renal injury in mice.
authors.affiliation: College of Veterinary Medicine, Jilin University, Jilin, Changchun 130062, People's Republic of China.
authors.forename: Xuexiu
authors.initials: X
authors.lastname: He
authors.affiliation: College of Veterinary Medicine, Jilin University, Jilin, Changchun 130062, People's Republic of China.
authors.forename: Chunmei
authors.initials: C
authors.lastname: Li
authors.affiliation: College of Veterinary Medicine, Jilin University, Jilin, Changchun 130062, People's Republic of China.
authors.forename: Zhengkai
authors.initials: Z
authors.lastname: Wei
authors.affiliation: College of Veterinary Medicine, Jilin University, Jilin, Changchun 130062, People's Republic of China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Wang
authors.affiliation: College of Veterinary Medicine, Jilin University, Jilin, Changchun 130062, People's Republic of China.
authors.forename: Jinhua
authors.initials: J
authors.lastname: Kou
authors.affiliation: College of Veterinary Medicine, Jilin University, Jilin, Changchun 130062, People's Republic of China.
authors.forename: Weijian
authors.initials: W
authors.lastname: Liu
authors.affiliation: College of Veterinary Medicine, Jilin University, Jilin, Changchun 130062, People's Republic of China.
authors.forename: Mingyu
authors.initials: M
authors.lastname: Shi
authors.affiliation: College of Veterinary Medicine, Jilin University, Jilin, Changchun 130062, People's Republic of China.
authors.forename: Zhengtao
authors.initials: Z
authors.lastname: Yang
authors.affiliation: College of Veterinary Medicine, Jilin University, Jilin, Changchun 130062, People's Republic of China. Electronic address: fuyunhesky@sina.com.
authors.forename: Yunhe
authors.initials: Y
authors.lastname: Fu
mesh_terms: D000818:Animals; D047310:Apigenin / Q000494:pharmacology*; D002945:Cisplatin / Q000009:adverse effects*; D019610:Cytoprotection / Q000187:drug effects*; D007668:Kidney / Q000166:cytology / Q000187:drug effects* / Q000293:injuries* / Q000378:metabolism; D008297:Male; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000378:metabolism; D051996:Transcription Factor RelA / Q000378:metabolism; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species; D051996:Transcription Factor RelA; D047310:Apigenin; D048051:p38 Mitogen-Activated Protein Kinases; D002945:Cisplatin
keywords: Apigenin; Cisplatin; Inflammation; Kidney; Oxidative stress