title: PRESERVATIVES FROM THE EYE DROPS AND THE OCULAR SURFACE.
abstract: The use of preservatives in eye drops (eyewashes) has known glory at the beginning, but the side effects that they have on the ocular surface have led to a decrease of their popularity. Lachrymal film dysfunction, ocular hyperemia, dotted keratitis or toxic keratopathy were reported and analyzed in terms of pathophysiological mechanism of the role played by preservatives in ophthalmic drops (eyewashes). This article reviews the most common preservatives and the existing alternatives for the maintenance of the eye sterile drops. Keywords: preservatives, eye drops, ocular surface
authors.forename: Mihaela Cristina
authors.initials: MC
authors.lastname: Coroi
authors.forename: Simona
authors.initials: S
authors.lastname: Bungau
authors.forename: Mirela
authors.initials: M
authors.lastname: Tit
mesh_terms: D003229:Conjunctival Diseases / Q000139:chemically induced*; D003316:Corneal Diseases / Q000139:chemically induced*; D006801:Humans; D007634:Keratitis / Q000139:chemically induced; D066234:Lacrimal Elimination / Q000187:drug effects; D009883:Ophthalmic Solutions / Q000009:adverse effects*; D011310:Preservatives, Pharmaceutical / Q000009:adverse effects*
chemical_list: D009883:Ophthalmic Solutions; D011310:Preservatives, Pharmaceutical