title: Noncoding RNAs in Regulation of Cancer Metabolic Reprogramming.
abstract: Since the description of the Warburg effect 90 years ago, metabolic reprogramming has been gradually recognized as a major hallmark of cancer cells. Mounting evidence now indicates that cancer is a kind of metabolic disease, quite distinct from conventional perception. While metabolic alterations in cancer cells have been extensively observed in glucose, lipid, and amino acid metabolisms, its underlying regulatory mechanisms are still poorly understood. Noncoding RNA, also known as the "dark matter in life," functions through various mechanisms at RNA level regulating different biological pathways. The last two decades have witnessed the booming of noncoding RNA study on microRNA (miRNA), long noncoding RNA (lncRNA), circular RNA (circRNA), PIWI-interacting RNA (piRNA), etc. In this chapter, we will discuss the regulatory roles of noncoding RNAs on cancer metabolism.
authors.affiliation: Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, and School of Life Science, University of Science and Technology of China, Hefei, 230027, China.
authors.forename: Dongdong
authors.initials: D
authors.lastname: Yang
authors.affiliation: Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, and School of Life Science, University of Science and Technology of China, Hefei, 230027, China.
authors.forename: Linchong
authors.initials: L
authors.lastname: Sun
authors.affiliation: Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, and School of Life Science, University of Science and Technology of China, Hefei, 230027, China.
authors.forename: Zhaoyong
authors.initials: Z
authors.lastname: Li
authors.affiliation: Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, and School of Life Science, University of Science and Technology of China, Hefei, 230027, China. pgao2@ustc.edu.cn.
authors.forename: Ping
authors.initials: P
authors.lastname: Gao
mesh_terms: D065150:Cellular Reprogramming / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D012313:RNA / Q000235:genetics / Q000378:metabolism; D000079962:RNA, Circular; D062085:RNA, Long Noncoding / Q000235:genetics*; D034741:RNA, Small Interfering / Q000235:genetics / Q000378:metabolism
chemical_list: D035683:MicroRNAs; D000079962:RNA, Circular; D062085:RNA, Long Noncoding; D034741:RNA, Small Interfering; D012313:RNA
keywords: Amino acid; Cancer metabolism; Glucose; Lipid; Long noncoding RNA; MicroRNA; Noncoding RNA