title: A Protocol for NMR Analysis of the Enantiomeric Excess of Chiral Diols Using an Achiral Diboronic Acid Template.
abstract: A practically simple derivatization protocol for determining the enantiopurity of chiral diols by (1)H NMR spectroscopic analysis is described. Diols were treated with 0.5 equiv of 1,3-phenyldiboronic acid to afford mixtures of diastereomeric boronate esters whose homochiral/heterochiral ratios are an accurate reflection of the diol's enantiopurity.
authors.affiliation: Department of Chemistry, University of Bath , Claverton Down, Bath, BA2 7AY, U.K.
authors.forename: David A
authors.initials: DA
authors.lastname: Tickell
authors.affiliation: Department of Chemistry, University of Bath , Claverton Down, Bath, BA2 7AY, U.K.
authors.forename: Emma V
authors.initials: EV
authors.lastname: Lampard
authors.affiliation: Department of Chemistry, University of Bath , Claverton Down, Bath, BA2 7AY, U.K.
authors.forename: John P
authors.initials: JP
authors.lastname: Lowe
authors.affiliation: Department of Chemistry, University of Bath , Claverton Down, Bath, BA2 7AY, U.K.
authors.forename: Tony D
authors.initials: TD
authors.lastname: James
authors.affiliation: Department of Chemistry, University of Bath , Claverton Down, Bath, BA2 7AY, U.K.
authors.forename: Steven D
authors.initials: SD
authors.lastname: Bull