title: Comparison of the analgesic efficacy of preoperative/postoperative oral dexketoprofen trometamol in third molar surgery: A randomized clinical trial.
abstract: The aim of this study was to compare the efficacy of preoperative and postoperative dexketoprofen trometamol for pain control after third molar surgery. Sixty subjects indicated for impacted mandibular third molar surgery were randomly assigned to two groups: preoperative (group 1, n = 30) and postoperative (group 2, n = 30) administration. Group 1 received 25 mg of dexketoprofen trometamol 30 min before surgery and 1 placebo capsule (same color and size with active drug) immediately after surgery. Group 2 received the placebo capsule 30 min before surgery and 25 mg of dexketoprofen trometamol immediately after surgery. Pain intensity was assessed using a numeric rating scale (NRS) during the first 8 h. The time of the need for a second dose of dexketoprofen trometamol, after the first administration, was recorded. The data were analyzed using mixed-model repeated-measures (MMRM), Wilcoxon rank-sum, and Kaplan-Meier analysis. After the 8 h period, no statistically significant difference was observed in the intensity of pain (MMRM, p = 0.41); and no significant difference in the time for a second dose (p = 0.956). In conclusion, preoperative administration of dexketoprofen trometamol is a reasonable clinical approach that is as effective as conventional postoperative pharmacological treatment, with the advantage of allowing early analgesia before pain develops. (ClinicalTrials.gov: NCT02380001).
authors.affiliation: Clinical Epidemiology Department, Faculty of Medicine, San Luis Potosi University, San Luis Potosi, SLP, Mexico.
authors.forename: Vicente
authors.initials: V
authors.lastname: Esparza-Villalpando
authors.affiliation: Diagnostic and Surgical Sciences Department, Faculty of Dentistry, Costa Rica University, San Jose, Costa Rica.
authors.forename: Daniel
authors.initials: D
authors.lastname: Chavarria-Bolaños
authors.affiliation: Clinical Epidemiology Department, Faculty of Medicine, San Luis Potosi University, San Luis Potosi, SLP, Mexico.
authors.forename: Antonio
authors.initials: A
authors.lastname: Gordillo-Moscoso
authors.affiliation: Stomatology Department, Aguascalientes University, Aguascalientes, AGS, Mexico.
authors.forename: David
authors.initials: D
authors.lastname: Masuoka-Ito
authors.affiliation: Oral and Maxilofacial Surgery Department, Faculty of Dentistry, San Luis Potosi University, San Luis Potosi, SLP, Mexico.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Martinez-Rider
authors.affiliation: Pharmacology Department, Faculty of Dentistry, Baja California University, Mexicali, BC, Mexico.
authors.forename: Mario
authors.initials: M
authors.lastname: Isiordia-Espinoza
authors.affiliation: Basic Sciences Laboratory, Faculty of Dentistry, San Luis Potosi University, San Luis Potosi, SLP, Mexico. Electronic address: apozos@uaslp.mx.
authors.forename: Amaury
authors.initials: A
authors.lastname: Pozos-Guillen
mesh_terms: D000293:Adolescent; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007660:Ketoprofen / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008297:Male; D008964:Molar, Third / Q000601:surgery*; D059408:Pain Management; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control*; D011446:Prospective Studies; D014081:Tooth Extraction; D016896:Treatment Outcome; D014325:Tromethamine / Q000008:administration & dosage*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D014325:Tromethamine; D007660:Ketoprofen; C118296:dexketoprofen trometamol
keywords: Dexketoprofen trometamol; Human pain model; Pre-emptive analgesia; Third molar surgery