title: Comparison of Different Induction Doses of Rocuronium and Vecuronium in Neuroanaesthesia Practice.
abstract: OBJECTIVE
  To evaluate the efficiency of use of rocuronium and vecuronium in different dose regimens in neuroanaesthesia practice in terms of intubation time and first additional dose requirement.
  
  
  METHODS
  Sixty-eight neurosurgery patients with intracranial mass that were operated on were included in our study. Patients were randomly divided into 4 groups according to the induction dose of neuromuscular blocker (NMB) as: Group 1: Vecuronium 0.1 mg kg(-1), Group 2: Priming, 20% of total vecuronium (0.1 mg kg(-1)) needed for induction injected 5 minutes before induction and then the rest used for induction, Group 3: Rocuronium group: 0.6 mg kg(-1), Group 4: Rocuronium with rapid-sequence induction dose (RSID) (1.2 mg kg(-1)). TOF (Train of four) test was used to decide on intubation and an additional NMB dose during surgery. Intubation quality, time from induction to intubation, time until the first additional NMB dose and subsequent NMB dose intervals were recorded.
  
  
  RESULTS
  The RSID of rocuronium provided a significantly shorter time period for intubation against the other groups. Also, the time period from induction to first additional NMB requirement was significantly longer in the RSID group than the others. There were no statistically significant differences between the groups' in terms of time period for monitorisation, positioning and start of surgery.
  
  
  CONCLUSIONS
  With the use of RSID of rocuronium, it was seen that excellent intubation quality is provided at around 1 minute and, with its longer duration of action until a first additional dose, it covers the time period for monitorisation, positioning and start of surgery. Because of these effects, we think that RSID of rocuronium may be a better choice of dose regimen for neuroanaesthesia practice.
authors.affiliation: Department of Anaesthesiology and Reanimation, Faculty of Medicine, İstanbul University, İstanbul, Turkey.
authors.forename: Behiye
authors.initials: B
authors.lastname: Doğruel
authors.affiliation: Department of Anaesthesiology and Reanimation, Faculty of Medicine, İstanbul University, İstanbul, Turkey.
authors.forename: Giray
authors.initials: G
authors.lastname: Varnalı
authors.affiliation: Department of Anaesthesiology and Reanimation, Faculty of Medicine, İstanbul University, İstanbul, Turkey.
authors.forename: Çiğdem
authors.initials: Ç
authors.lastname: Selek
authors.affiliation: Department of Anaesthesiology and Reanimation, Faculty of Medicine, İstanbul University, İstanbul, Turkey.
authors.forename: Lütfi
authors.initials: L
authors.lastname: Telci
authors.affiliation: Department of Anaesthesiology and Reanimation, Faculty of Medicine, İstanbul University, İstanbul, Turkey.
authors.forename: İbrahim Özkan
authors.initials: İÖ
authors.lastname: Akıncı
keywords: Rocuronium; neuromuscular blockade; neurosurgery Abstract; priming; vecuronium