title: Molecular and cellular mechanisms underlying the therapeutic effects of budesonide in asthma.
abstract: Inhaled glucocorticoids are the mainstay of asthma treatment. Indeed, such therapeutic agents effectively interfere with many pathogenic circuits underpinning asthma. Among these drugs, during the last decades budesonide has been probably the most used molecule in both experimental studies and clinical practice. Therefore, a large body of evidence clearly shows that budesonide, either alone or in combination with long-acting bronchodilators, provides a successful control of asthma in many patients ranging throughout the overall spectrum of disease severity. These excellent therapeutic properties of budesonide basically depend on its molecular mechanisms of action, capable of inhibiting within the airways the activity of multiple immune-inflammatory and structural cells involved in asthma pathobiology.
authors.affiliation: Department of Medical and Surgical Sciences, Section of Respiratory Diseases, University "Magna Græcia" of Catanzaro, Italy. Electronic address: pelaia@unicz.it.
authors.forename: Girolamo
authors.initials: G
authors.lastname: Pelaia
authors.affiliation: Department of Medicine and Surgery, Section of Respiratory Diseases, University of Salerno, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Vatrella
authors.affiliation: Department of Medical and Surgical Sciences, Section of Respiratory Diseases, University "Magna Græcia" of Catanzaro, Italy.
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Busceti
authors.affiliation: Pulmonary Rehabilitation, "Fondazione Don Carlo Gnocchi", Milan, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Fabiano
authors.affiliation: Department of Health Science, University "Magna Græcia" of Catanzaro, Italy.
authors.forename: Rosa
authors.initials: R
authors.lastname: Terracciano
authors.affiliation: Department of Experimental Medicine, Unit of Pharmacology, Second University of Naples, Italy.
authors.forename: Maria Gabriella
authors.initials: MG
authors.lastname: Matera
authors.affiliation: Department of Medical and Surgical Sciences, Section of Respiratory Diseases, University "Magna Græcia" of Catanzaro, Italy.
authors.forename: Rosario
authors.initials: R
authors.lastname: Maselli
mesh_terms: D000818:Animals; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D019819:Budesonide / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D005938:Glucocorticoids / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D012720:Severity of Illness Index
chemical_list: D018927:Anti-Asthmatic Agents; D001993:Bronchodilator Agents; D005938:Glucocorticoids; D019819:Budesonide
keywords: Asthma; Budesonide; Glucocorticoids