title: New Carbocyclic Amino Acid Derivatives Inhibit Infection Caused by Highly Pathogenic Influenza A Virus Strain (H5N1).
abstract: New amino acid derivatives with carbocycles of adamantine and quinaldic acid were synthesized and their in vitro antiviral activity against influenza A/H5N1 virus was evaluated. Experiments on cultured embryonic porcine kidney epithelial cells showed that amino acid derivatives suppressed viral replication. Tret-butyloxycarbonyl-DL-methionylsulfonyl-1-adamantayl ethylamine and benzyloxycarbonyl-L-trypthophanyl-1-adamantayl ethylamine compounds demonstrated high activity in all in vitro experiments. Moreover, some compounds showed virucidal activity against influenza A/H5N1 virus.
authors.affiliation: D. I. Ivanovsky Institute of Virology, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Shibnev
authors.affiliation: D. I. Ivanovsky Institute of Virology, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia. gtim@fmradio.ru.
authors.forename: T M
authors.initials: TM
authors.lastname: Garaev
authors.affiliation: D. I. Ivanovsky Institute of Virology, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: P G
authors.initials: PG
authors.lastname: Deryabin
authors.affiliation: D. I. Ivanovsky Institute of Virology, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: M P
authors.initials: MP
authors.lastname: Finogenova
authors.affiliation: D. I. Ivanovsky Institute of Virology, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: A G
authors.initials: AG
authors.lastname: Botikov
authors.affiliation: D. I. Ivanovsky Institute of Virology, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: D V
authors.initials: DV
authors.lastname: Mishin
mesh_terms: D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical; D053124:Influenza A Virus, H5N1 Subtype / Q000187:drug effects* / Q000502:physiology; D020128:Inhibitory Concentration 50; D012299:Rimantadine / Q000494:pharmacology*; D034421:Sus scrofa; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000596:Amino Acids; D000998:Antiviral Agents; D012299:Rimantadine
keywords: adamantane derivatives; amino acids; antiviral activity; influenza A/H5N1 virus; remantadine