title: Serum 25-hydroxyvitamin D level and incident type 2 diabetes in older men, the Osteoporotic Fractures in Men (MrOS) study.
abstract: The association between vitamin D status and diabetes risk is inconsistent among observational studies, and most of the available studies have been with women. In the present study we investigated the association between serum 25-hydroxyvitamin D (25(OH)D) levels and incident type 2 diabetes (T2D) in older men (≥65years old) who participated in the multisite Osteoporotic Fractures in Men (MrOS) study enrolled from March 2000 to April 2002. Baseline 25(OH)D levels were available in 1939 subjects without prevalent T2D. Clinical information, body mass index (BMI) and other factors related to T2D were assessed at the baseline visit. Incident diabetes, defined by self-report and medication use, was determined over an average follow-up of 6.4years. At baseline, participants were, on average, 73.3 (±5.7) years old, had a mean BMI in the overweight range (27.2kg/m(2)±3.6) and had total serum 25(OH)D of 26.1ng/ml (±8.3). Incident diabetes was diagnosed in 139 subjects. Cox regression analysis showed a trend toward a protective effect of higher 25(OH)D levels with a lower risk of T2D (HR 0.87, 95% CI: 0.73-1.04 per 1 SD increase of 25(OH)D). After adjusted for BMI and other potential confounders, the relationship between 25(OH)D levels and incident diabetes was further attenuated (HR 1.03, 95% CI 0.85-1.25). No significant difference in the incidence of diabetes emerged after analyzing study subjects according to baseline 25(OH)D quartiles. In conclusion, 25(OH)D levels were not associated with incident T2D in older men.
authors.affiliation: Università Campus Bio-Medico di Roma, Italy; Division of Bone and Mineral Diseases, Washington University in St Louis. Electronic address: n.napoli@unicampus.it.
authors.forename: Nicola
authors.initials: N
authors.lastname: Napoli
authors.affiliation: University of California, San Francisco, CA, USA; San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
authors.forename: Anne L
authors.initials: AL
authors.lastname: Schafer
authors.affiliation: California Pacific Medical Center, San Francisco, CA, USA.
authors.forename: Li-Yung
authors.initials: LY
authors.lastname: Lui
authors.affiliation: Department of Epidemiology, Center for Aging and Population Health, Graduate School of Public Health, USA.
authors.forename: Jane A
authors.initials: JA
authors.lastname: Cauley
authors.affiliation: Department of Epidemiology, Center for Aging and Population Health, Graduate School of Public Health, USA.
authors.forename: Elsa S
authors.initials: ES
authors.lastname: Strotmeyer
authors.affiliation: Center for Health Research NW, Kaiser Permanente, USA.
authors.forename: Erin S
authors.initials: ES
authors.lastname: Le Blanc
authors.affiliation: Stanford University, USA.
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Hoffman
authors.affiliation: Veterans Affairs Health Care System, Portland, OR, USA.
authors.forename: Christine G
authors.initials: CG
authors.lastname: Lee
authors.affiliation: University of California, San Francisco, CA, USA.
authors.forename: Dennis M
authors.initials: DM
authors.lastname: Black
authors.affiliation: University of California, San Francisco, CA, USA.
authors.forename: Ann V
authors.initials: AV
authors.lastname: Schwartz
mesh_terms: D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008297:Male; D058866:Osteoporotic Fractures / Q000097:blood*; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: Older men; Type 2 diabetes; Vitamin D