title: Trends, characteristics, and incidence of anaphylaxis in 2001-2010: A population-based study.
abstract: Anaphylaxis is a potentially life-threatening systemic allergic reaction.
  
  
  
  We aimed to determine the incidence rate and causes of anaphylaxis during a 10-year period in Olmsted County, Minnesota.
  
  
  
  Using the resources of the Rochester Epidemiology Project, a comprehensive records linkage system, we performed a population-based incidence study in Olmsted County, Minnesota, from 2001 through 2010. All cases with a diagnosis of anaphylactic shock and 20% of cases with related diagnoses were manually reviewed. The relationships of age group, sex, and year of anaphylaxis with incidence rates were assessed by fitting Poisson regression models.
  
  
  
  Six hundred thirty-one cases of anaphylaxis were identified. The median age was 31 years (interquartile range, 19-44 years). The overall age- and sex-adjusted incidence rate was 42 (95% CI, 38.7-45.3) per 100,000 person-years. There was a significant increase in the overall incidence of anaphylaxis during the study period, with an average increase of 4.3% per year (P < .001). In addition, there was a 9.8% increase per year in the incidence rate of food-related anaphylaxis. Food-related anaphylaxis was most common in children aged 0 to 9 years, venom-related anaphylaxis was most common in those 20 to 39 years of age, and medication-related anaphylaxis was most common in those 30 to 39 years of age.
  
  
  
  The overall incidence rate of anaphylaxis was 42 per 100,000 person-years from 2001-2010 in Olmsted County, Minnesota. The incidence of anaphylaxis increased over time, and several inciting triggers were uniquely associated with different age groups.
authors.affiliation: Department of Emergency Medicine, Mayo Clinic Health System, Mankato, Minn. Electronic address: lee.sangil@mayo.edu.
authors.forename: Sangil
authors.initials: S
authors.lastname: Lee
authors.affiliation: Department of Emergency Medicine, Mayo Clinic, Rochester, Minn.
authors.forename: Erik P
authors.initials: EP
authors.lastname: Hess
authors.affiliation: Department of Emergency Medicine, Mayo Clinic, Rochester, Minn.
authors.forename: Christine
authors.initials: C
authors.lastname: Lohse
authors.affiliation: Department of Emergency Medicine, Mayo Clinic, Rochester, Minn.
authors.forename: Waqas
authors.initials: W
authors.lastname: Gilani
authors.affiliation: Department of Epidemiology, Mayo Clinic, Rochester, Minn.
authors.forename: Alanna M
authors.initials: AM
authors.lastname: Chamberlain
authors.affiliation: Department of Emergency Medicine, Mayo Clinic, Rochester, Minn.
authors.forename: Ronna L
authors.initials: RL
authors.lastname: Campbell
mesh_terms: D000293:Adolescent; D000328:Adult; D000707:Anaphylaxis / Q000453:epidemiology* / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D004342:Drug Hypersensitivity / Q000150:complications; D005260:Female; D005512:Food Hypersensitivity / Q000150:complications; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D008910:Minnesota / Q000453:epidemiology; D014688:Venoms / Q000009:adverse effects; D055815:Young Adult
chemical_list: D014688:Venoms
keywords: Anaphylaxis; epidemiology; food allergy; incidence rate; medication allergy; venom allergy