title: Viral load kinetics of Zika virus in plasma, urine and saliva in a couple returning from Martinique, French West Indies.
abstract: While the rapid spread of Zika virus (ZIKV) in South America has been declared a public health emergency few data are available on the kinetics of the virus load and the specific antibodies in individual patients. This report describes the kinetics of ZIKV decay in the body compartments and the kinetics of anti ZIKV IgG and IgM of two people returning from Martinique, French West Indies. ZIKV remained detectable in the plasma for roughly 2 weeks indicating that mosquito control measures should be prolonged accordingly. Remarkably, their urine samples consistently tested positive for even longer. The antibodies responses were different between the two patients but for both the rapid onset of IgM allowed a diagnosis from the end of the first week.
authors.affiliation: Toulouse University Hospital, Toulouse, France. Electronic address: fourcade.c@chu-toulouse.fr.
authors.forename: Camille
authors.initials: C
authors.lastname: Fourcade
authors.affiliation: Toulouse University Hospital, Toulouse, France. Electronic address: mansuy.jm@chu-toulouse.fr.
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Mansuy
authors.affiliation: Toulouse University Hospital, Toulouse, France. Electronic address: dutertre.m@chu-toulouse.fr.
authors.forename: Marine
authors.initials: M
authors.lastname: Dutertre
authors.affiliation: Saint-Gaudens Hospital, Saint-Gaudens, France. Electronic address: marie.delpech@ch-saintgaudens.fr.
authors.forename: Marie
authors.initials: M
authors.lastname: Delpech
authors.affiliation: Toulouse University Hospital, Toulouse, France. Electronic address: marchou.b@chu-toulouse.fr.
authors.forename: Bruno
authors.initials: B
authors.lastname: Marchou
authors.affiliation: Toulouse University Hospital, Toulouse, France; INSERM UMR1043, Toulouse, France. Electronic address: delobel.p@chu-toulouse.fr.
authors.forename: Pierre
authors.initials: P
authors.lastname: Delobel
authors.affiliation: Toulouse University Hospital, Toulouse, France; INSERM UMR1043, Toulouse, France. Electronic address: izopet.j@chu-toulouse.fr.
authors.forename: Jacques
authors.initials: J
authors.lastname: Izopet
authors.affiliation: Toulouse University Hospital, Toulouse, France; INSERM UMR1043, Toulouse, France. Electronic address: martin-blondel.g@chu-toulouse.fr.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Martin-Blondel
mesh_terms: D000368:Aged; D000914:Antibodies, Viral / Q000097:blood; D000076263:Communicable Diseases, Imported / Q000821:virology*; D005191:Family Characteristics; D005260:Female; D005602:France; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008395:Martinique; D008875:Middle Aged; D010949:Plasma / Q000821:virology; D012463:Saliva / Q000821:virology; D013997:Time Factors; D014556:Urine / Q000821:virology; D019562:Viral Load; D000071244:Zika Virus / Q000302:isolation & purification*; D000071243:Zika Virus Infection / Q000821:virology*
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M
keywords: Antibodies; Kinetics; Plasma; RNA; Urine; Zika virus infection