title: Effectiveness of sugammadex for cerebral ischemia/reperfusion injury.
abstract: Cerebral ischemia may cause permanent brain damage and behavioral dysfunction. The efficacy and mechanisms of pharmacological treatments administered immediately after cerebral damage are not fully known. Sugammadex is a licensed medication. As other cyclodextrins have not passed the necessary phase tests, trade preparations are not available, whereas sugammadex is frequently used in clinical anesthetic practice. Previous studies have not clearly described the effects of the cyclodextrin family on cerebral ischemia/reperfusion (I/R) damage. The aim of this study was to determine whether sugammadex had a neuroprotective effect against transient global cerebral ischemia. Animals were assigned to control, sham-operated, S 16 and S 100 groups. Transient global cerebral ischemia was induced by 10-minute occlusion of the bilateral common carotid artery, followed by 24-hour reperfusion. At the end of the experiment, neurological behavior scoring was performed on the rats, followed by evaluation of histomorphological and biochemical measurements. Sugammadex 16 mg/kg and 100 mg/kg improved neurological outcome, which was associated with reductions in both histological and neurological scores. The hippocampus TUNEL (terminal deoxynucleotidyl transferase dUTP nick end labeling) and caspase results in the S 16 and S 100 treatment groups were significantly lower than those of the I/R group. Neurological scores in the treated groups were significantly higher than those of the I/R group. The study showed that treatment with 16 mg/kg and 100 mg/kg sugammadex had a neuroprotective effect in a transient global cerebral I/R rat model. However, 100 mg/kg sugammadex was more neuroprotective in rats.
authors.affiliation: Department of Anesthesiology and Reanimation, School of Medicine, Dokuz Eylul University, Izmir, Turkey. Electronic address: sozbilginmd@gmail.com.
authors.forename: Sule
authors.initials: S
authors.lastname: Ozbilgin
authors.affiliation: Department of Anesthesiology and Reanimation, School of Medicine, Dokuz Eylul University, Izmir, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Yılmaz
authors.affiliation: Department of Anesthesiology and Reanimation, School of Medicine, Dokuz Eylul University, Izmir, Turkey.
authors.forename: Bekir Ugur
authors.initials: BU
authors.lastname: Ergur
authors.affiliation: Department of Anesthesiology and Reanimation, School of Medicine, Dokuz Eylul University, Izmir, Turkey.
authors.forename: Volkan
authors.initials: V
authors.lastname: Hancı
authors.affiliation: Department of Anesthesiology and Reanimation, School of Medicine, Dokuz Eylul University, Izmir, Turkey.
authors.forename: Seda
authors.initials: S
authors.lastname: Ozbal
authors.affiliation: Department of Anesthesiology and Reanimation, School of Medicine, Dokuz Eylul University, Izmir, Turkey.
authors.forename: Serhan
authors.initials: S
authors.lastname: Yurtlu
authors.affiliation: Department of Anesthesiology and Reanimation, School of Medicine, Dokuz Eylul University, Izmir, Turkey.
authors.forename: Sakize Ferim
authors.initials: SF
authors.lastname: Gunenc
authors.affiliation: Department of Anesthesiology and Reanimation, School of Medicine, Dokuz Eylul University, Izmir, Turkey.
authors.forename: Bahar
authors.initials: B
authors.lastname: Kuvaki
authors.affiliation: Department of Anesthesiology and Reanimation, School of Medicine, Dokuz Eylul University, Izmir, Turkey.
authors.forename: Burcu Ataseven
authors.initials: BA
authors.lastname: Kucuk
authors.affiliation: Department of Anesthesiology and Reanimation, School of Medicine, Dokuz Eylul University, Izmir, Turkey.
authors.forename: Ali Rıza
authors.initials: AR
authors.lastname: Sisman
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000188:drug therapy / Q000473:pathology; D002545:Brain Ischemia / Q000188:drug therapy* / Q000473:pathology; D053148:Caspase 3 / Q000378:metabolism; D002452:Cell Count; D020287:In Situ Nick-End Labeling; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000473:pathology; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000473:pathology; D000077122:Sugammadex; D016896:Treatment Outcome; D047408:gamma-Cyclodextrins / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D053148:Caspase 3
keywords: Hypoxia; Ischemia; Neuroprotections sugammadex