title: Catatonia in disulfiram intoxication - a case report and a brief overview of the literature.
abstract: Catatonic syndromes could accompany a variety of psychiatric and medical conditions. The most common conditions underlying catatonia are affective disorders followed by schizophrenia, but several medical conditions including intoxications affecting the central nervous system can also present with catatonic signs and symptoms. Therapeutic doses of disulfiram could induce catatonia with or without accompanying psychosis or mood disorder. A case of disulfiram intoxication manifesting with catatonia is reported here together with a brief overview of the literature. A patient was admitted to the toxicology ward after a suicide attempt with approximately 20 g of disulfiram. On transfer to the psychiatric ward, she was sitting still, in a semi-stuporous state and displayed motiveless resistance to instructions or attempts to move (active negativism). She was unresponsive to most of the questions (mutism), occasionally verbigerated 1-2 words and stared for more than 20 seconds between shifting attention. After developing a comatosus state her treatment continued at the toxicology ward, where a contrast-enhanced computer tomography scan revealed bilateral emollition of 1.5 cm diameter in both nucleus lentiformis at the level of the third ventricle. Following treatment her condition improved and she benefited of rehabilitation facility and a second psychiatric treatment. She was discharged free of neurological and psychiatric symptoms. In conclusion, we underscore the importance of accurate diagnosis of the underlying psychiatric or medical condition when encountering a fast emerging catatonic syndrome and focus first on treating the causative condition while simultaneously attempting symptomatic treatment of catatonia.
authors.affiliation: Centre for Psychiatry and Addiction Medicine, Szent István and Szent László Hospitals, Budapest, Hungary. gazdag@lamb.hu.
authors.forename: Rozalia
authors.initials: R
authors.lastname: Takacs
authors.forename: Flora
authors.initials: F
authors.lastname: Milan
authors.forename: Gabor S
authors.initials: GS
authors.lastname: Ungvari
authors.forename: Gabor
authors.initials: G
authors.lastname: Faludi
authors.forename: Gabor
authors.initials: G
authors.lastname: Gazdag
mesh_terms: D065086:Acetaldehyde Dehydrogenase Inhibitors / Q000506:poisoning*; D002389:Catatonia / Q000139:chemically induced*; D004221:Disulfiram / Q000506:poisoning*; D005260:Female; D006801:Humans; D019964:Mood Disorders; D011618:Psychotic Disorders; D012559:Schizophrenia
chemical_list: D065086:Acetaldehyde Dehydrogenase Inhibitors; D004221:Disulfiram