title: Isolated CMV infection causing perianal and sacral ulceration in a patient with aids.
abstract: Cytomegalovirus (CMV) is a DNA virus estimated to infect 70-90% of the worlds population, producing minimal symptoms in immunocompetent hosts. In the immunocompromised host, CMV infection can be potentially fatal, producing systemic or localized forms. We report the case of a 52-year-old female with acquired immunodeficiency virus (AIDS) who presented multiple sacral and perineal ulcers clinically and histopathologically consistent with CMV ulcerations. We discuss the patients clinical presentation and histologic findings to remind physicians to consider CMV as a cause for cutaneous and systemic infection in the immunocompromised host.
authors.affiliation: University of Nebraska Medical Center College of Medicine, Omaha, Nebraska.
authors.forename: D J
authors.initials: DJ
authors.lastname: Klug
authors.affiliation: Departments of Pathology, University of Virginia Health System, Charlottesville, Virginia.
authors.forename: M D
authors.initials: MD
authors.lastname: Darling
authors.affiliation: Departments of Pathology, University of Virginia Health System, Charlottesville, Virginia.
authors.forename: J R
authors.initials: JR
authors.lastname: Kaley
authors.affiliation: Medical Institute of Ministry of Interior (MVR-Sofia), Department of Dermatology, Venereology and Dermatologic Surgery, Sofia, Bulgaria.
authors.forename: G
authors.initials: G
authors.lastname: Tchernev
authors.affiliation: "Onkoderma"- Policlinic for Dermatology and Dermatologic Surgery, Sofia, Bulgaria; Department of Dermatology and Venereology, Medical University of Plovdiv, Medical Faculty, Plovdiv, Bulgaria.
authors.forename: A A
authors.initials: AA
authors.lastname: Chokoeva
authors.affiliation: Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Wollina
authors.affiliation: Department of Dermatology, University of Rome G. Marconi Rome, Italy.
authors.forename: T
authors.initials: T
authors.lastname: Lotti
authors.affiliation: History Department, G. Marconi University, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Fioranelli
authors.affiliation: University B.I.S. Group of Institutions, Punjab Technical University, Punjab, India.
authors.forename: M G
authors.initials: MG
authors.lastname: Roccia
authors.affiliation: Department Medicinal Information and Non-Interventional Studies, Bulgarian Drug Agency, Sofia, Bulgaria.
authors.forename: G K
authors.initials: GK
authors.lastname: Maximov
authors.affiliation: Department of dermatology, University of Virginia Health System, Charlottesville, Virginia.
authors.forename: A L
authors.initials: AL
authors.lastname: Gagnon
authors.affiliation: Departments of Pathology, University of Virginia Health System, Charlottesville, Virginia.
authors.forename: J W
authors.initials: JW
authors.lastname: Patterson
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D001003:Anal Canal / Q000473:pathology*; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012447:Sacrum / Q000473:pathology*; D014456:Ulcer / Q000473:pathology*