title: Alendronate-Loaded Modified Drug Delivery Lipid Particles Intended for Improved Oral and Topical Administration.
abstract: The present paper focuses on solid lipid particles (SLPs), described in the literature as the most effective lipid drug delivery systems that have been introduced in the last decades, as they actually combine the advantages of polymeric particles, hydrophilic/lipophilic emulsions and liposomes. In the current study, we present our most recent advances in the preparation of alendronate (AL)-loaded SLPs prepared by hot homogenization and ultrasonication using various ratios of a self-emulsifying lipidic mixture of Compritol 888, Gelucire 44/14, and Cremophor A 25. The prepared AL-loaded SLPs were investigated for their physicochemical, morphological and structural characteristics by dynamic light scattering, differential scanning calorimetry, thermogravimetric and powder X-ray diffraction analysis, infrared spectroscopy, optical and scanning electron microscopy. Entrapment efficacy and actual drug content were assessed by a validated HPLC method. In vitro dissolution tests performed in simulated gastro-intestinal fluids and phosphate buffer solution pH 7.4 revealed a prolonged release of AL of 70 h. Additionally, release kinetics analysis showed that both in simulated gastrointestinal fluids and in phosphate buffer solution, AL is released from SLPs based on equal ratios of lipid excipients following zero-order kinetics, which characterizes prolonged-release drug systems.
authors.affiliation: Department of Pharmaceutical Technology, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy of Iasi, Universitatii Street, 16, Iasi 700115, Romania. ochiuzd@yahoo.com.
authors.forename: Lacramioara
authors.initials: L
authors.lastname: Ochiuz
authors.affiliation: Petru Poni Institute of Macromolecular Chemistry, Aleea, Grigore Ghica Voda, 41A, Iasi 700487, Romania. crgrig@icmpp.ro.
authors.forename: Cristian
authors.initials: C
authors.lastname: Grigoras
authors.affiliation: Department of Natural and Synthetic Polymers, Gheorghe Asachi Technical University of Iasi, Romania, Prof. Dr. Docent Dimitrie Mangeron Avenue, 73, Iasi 700050, Romania. marpopa2001@yahoo.fr.
authors.forename: Marcel
authors.initials: M
authors.lastname: Popa
authors.affiliation: Faculty of Mathematics, Alexandru I. Cuza University, 11 Bvd. Carol I, Iasi 700506, Romania. stoleriu@yahoo.com.
authors.forename: Iulian
authors.initials: I
authors.lastname: Stoleriu
authors.affiliation: Faculty of Mechanical Engineering, Gheorghe Asachi Technical University of Iasi, Romania, Prof. Dr. Docent Dimitrie Mangeron Avenue, 73, Iasi 700050, Romania. cornelmun@yahoo.com.
authors.forename: Corneliu
authors.initials: C
authors.lastname: Munteanu
authors.affiliation: Faculty of Medicine, Grigore T.Popa University of Medicine and Pharmacy Iasi, 16 Universitatii Street, Iasi 700115, Romania. dantimofte@yahoo.com.|Surgery Department, Sf. Spiridon Hospital, 1 Piata Independentei, Iasi 700111, Romania. dantimofte@yahoo.com.
authors.forename: Daniel
authors.initials: D
authors.lastname: Timofte
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy of Iasi, Universitatii Street, 16, Iasi 700115, Romania. nprofire@yahoo.com.
authors.forename: Lenuta
authors.initials: L
authors.lastname: Profire
authors.affiliation: Petru Poni Institute of Macromolecular Chemistry, Aleea, Grigore Ghica Voda, 41A, Iasi 700487, Romania. angrig@icmpp.ro.
authors.forename: Anca Giorgiana
authors.initials: AG
authors.lastname: Grigoras
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D019386:Alendronate / Q000008:administration & dosage*; D050071:Bone Density Conservation Agents / Q000008:administration & dosage*; D002152:Calorimetry, Differential Scanning; D004337:Drug Carriers; D016503:Drug Delivery Systems; D065546:Drug Liberation; D008055:Lipids / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry / Q000648:ultrastructure; D013057:Spectrum Analysis; D014961:X-Ray Diffraction
chemical_list: D050071:Bone Density Conservation Agents; D004337:Drug Carriers; D008055:Lipids; D008081:Liposomes; D019386:Alendronate
keywords: Compritol; Cremophore 25; Gelucire 44/14; alendronate; particles; prolonged release