title: Viral Noncoding RNAs in Cancer Biology.
abstract: Over 12 % of all human cancers are caused by oncoviruses, primarily including Epstein-Barr virus (EBV), high-risk human papillomaviruses (HPVs), hepatitis B and C viruses (HBV and HCV, respectively), and Kaposi's sarcoma herpesvirus (KSHV). In addition to viral oncoproteins, a variety of noncoding RNAs (ncRNAs) produced by oncoviruses have been recognized as important cofactors that contribute to the oncogenic events. In this chapter, we will focus on the recent understanding of the long and short noncoding RNAs, as well as microRNAs of the viruses, and discuss their roles in the biology of multistep oncogenesis mediated by established human oncoviruses.
authors.affiliation: Center for Molecular Medicine of Xiangya Hospital, Collaborative Innovation Center for Cancer Medicine, Central South University, Changsha, Hunan, 410008, China.|Key Laboratory of Molecular Radiation Oncology, Hunan, China.|Research Center for Technologies of Nucleic Acid-Based Diagnostics and Therapeutics, Hunan, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Li
authors.affiliation: Center for Molecular Medicine of Xiangya Hospital, Collaborative Innovation Center for Cancer Medicine, Central South University, Changsha, Hunan, 410008, China.|Key Laboratory of Molecular Radiation Oncology, Hunan, China.|Research Center for Technologies of Nucleic Acid-Based Diagnostics and Therapeutics, Hunan, China.
authors.forename: Shujun
authors.initials: S
authors.lastname: Fu
authors.affiliation: Center for Molecular Medicine of Xiangya Hospital, Collaborative Innovation Center for Cancer Medicine, Central South University, Changsha, Hunan, 410008, China. lunquansun@csu.edu.cn.|Key Laboratory of Molecular Radiation Oncology, Hunan, China. lunquansun@csu.edu.cn.|Research Center for Technologies of Nucleic Acid-Based Diagnostics and Therapeutics, Hunan, China. lunquansun@csu.edu.cn.
authors.forename: Lun-Quan
authors.initials: LQ
authors.lastname: Sun
mesh_terms: D015972:Gene Expression Regulation, Neoplastic; D016174:Hepacivirus / Q000235:genetics / Q000472:pathogenicity; D006515:Hepatitis B virus / Q000235:genetics / Q000472:pathogenicity; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000472:pathogenicity; D019288:Herpesvirus 8, Human / Q000235:genetics / Q000472:pathogenicity; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology / Q000821:virology; D027383:Papillomaviridae / Q000235:genetics / Q000472:pathogenicity; D062085:RNA, Long Noncoding / Q000235:genetics*; D058727:RNA, Small Untranslated / Q000235:genetics*
chemical_list: D035683:MicroRNAs; D062085:RNA, Long Noncoding; D058727:RNA, Small Untranslated
keywords: Cancer; MicroRNAs; Noncoding RNA; Oncoviruses