title: Dietary β-glucan enhances the contents of complement component 3 and factor B in eggs of zebrafish.
abstract: β-glucan has been shown to increase non-specific immunity and resistance against infections or pathogenic bacteria in several fish species, but no information is available regarding its trans-generational effects to date. Here we clearly demonstrated that β-glucan enhanced the contents of immune-relevant molecules C3 and Bf in eggs of zebrafish, and the embryos derived from β-1,3 glucan-treated zebrafish were more resistant to bacterial challenge than control embryos. Moreover, the transferred C3 and Bf were directly associated with the antimicrobial defense of early embryos. In addition, feeding female zebrafish with β-glucan had little detrimental effects on the number of spawned eggs and their embryonic development. Collectively, these data show for the first time that β-glucan can be safely used to promote the non-specific immunity in offspring of fishes.
authors.affiliation: Laboratory for Evolution & Development, Institute of Evolution & Marine Biodiversity and Department of Marine Biology Ocean University of China, Qingdao 266003, China; College of Life Science and Technology, Hong He University, Mengzi, Yunnan 661100, China.
authors.forename: Chengyan
authors.initials: C
authors.lastname: Jiang
authors.affiliation: Laboratory for Evolution & Development, Institute of Evolution & Marine Biodiversity and Department of Marine Biology Ocean University of China, Qingdao 266003, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.affiliation: Laboratory for Evolution & Development, Institute of Evolution & Marine Biodiversity and Department of Marine Biology Ocean University of China, Qingdao 266003, China.
authors.forename: Mengyang
authors.initials: M
authors.lastname: Li
authors.affiliation: Laboratory for Evolution & Development, Institute of Evolution & Marine Biodiversity and Department of Marine Biology Ocean University of China, Qingdao 266003, China.
authors.forename: Shousheng
authors.initials: S
authors.lastname: Liu
authors.affiliation: Laboratory for Evolution & Development, Institute of Evolution & Marine Biodiversity and Department of Marine Biology Ocean University of China, Qingdao 266003, China. Electronic address: sczhang@ouc.edu.cn.
authors.forename: Shicui
authors.initials: S
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000378:metabolism; D002478:Cells, Cultured; D003176:Complement C3 / Q000276:immunology / Q000378:metabolism*; D011415:Complement Factor B / Q000276:immunology / Q000378:metabolism*; D004032:Diet; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D005260:Female; D047109:Fetal Development; D007112:Immunity, Maternally-Acquired; D007114:Immunization; D011247:Pregnancy; D015027:Zebrafish / Q000276:immunology*; D015053:Zygote / Q000378:metabolism*; D047071:beta-Glucans / Q000008:administration & dosage*
chemical_list: D000890:Anti-Infective Agents; D003176:Complement C3; D004040:Dietary Carbohydrates; D047071:beta-Glucans; D011415:Complement Factor B
keywords: Danio rerio; Glucan; Immunostimulator; Maternal immunity; Zebrafish