title: Efficacy of 0.12% Chlorhexidine Gluconate for Non-Surgical Treatment of Peri-Implant Mucositis.
abstract: Because peri-implant mucositis may progress to peri-implantitis, effective treatment resulting in resolution of inflammation could prevent peri-implantitis. Current treatment protocols for this condition are still unpredictable. The purpose of this study is to analyze efficacy of non-surgical treatment for patients with peri-implant mucositis during a 6-month follow-up period.
  
  
  
  This controlled, randomized, double-masked clinical trial included 37 patients diagnosed with peri-implant mucositis, randomly assigned into test group (basic periodontal therapy + 0.12% chlorhexidine) with 61 implants; and control group (basic periodontal therapy + placebo) with 58 implants. Therapy consisted of adaptation of the full-mouth scaling and root planing protocol. Clinical parameters of visible plaque index (VPI), gingival bleeding index (GBI), probing depth (PD), and bleeding on probing (BOP) were measured in implants and were evaluated at baseline and at 1, 3, and 6 months post-therapy. Data were analyzed using the split-plot analysis of variance and χ2tests with a significance level of 5%.
  
  
  
  Intragroup analysis showed that VPI, GBI, PD, and BOP presented statistically significant improvements compared with baseline. No statistically significant differences were found between the test and control groups at any time.
  
  
  
  Both isolated mechanical therapy and its association with 0.12% chlorhexidine mouthwash reduced peri-implant mucositis. Therefore, 0.12% of chlorhexidine was not more effective than placebo.
authors.affiliation: Department of Dentistry, Federal University of Rio Grande do Norte, Natal, Brazil.
authors.forename: Karyna M
authors.initials: KM
authors.lastname: Menezes
authors.affiliation: Department of Dentistry, Federal University of Rio Grande do Norte, Natal, Brazil.
authors.forename: Anderson N
authors.initials: AN
authors.lastname: Fernandes-Costa
authors.affiliation: Department of Restorative Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
authors.forename: Reinaldo D
authors.initials: RD
authors.lastname: Silva-Neto
authors.affiliation: Department of Dentistry, Federal University of Rio Grande do Norte, Natal, Brazil.
authors.forename: Patrícia S
authors.initials: PS
authors.lastname: Calderon
authors.affiliation: Department of Dentistry, Federal University of Rio Grande do Norte, Natal, Brazil.
authors.forename: Bruno C V
authors.initials: BC
authors.lastname: Gurgel
mesh_terms: D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D002710:Chlorhexidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D015921:Dental Implants; D006801:Humans; D052016:Mucositis / Q000188:drug therapy*; D057873:Peri-Implantitis / Q000178:diet therapy*; D010512:Periodontal Index; D016896:Treatment Outcome
chemical_list: D000891:Anti-Infective Agents, Local; D015921:Dental Implants; C010882:chlorhexidine gluconate; D002710:Chlorhexidine
keywords: Chlorhexidine; clinical trials; dental implants; dental plaque; mucositis; oral hygiene