title: Genetic markers of inflammation may not contribute to metabolic traits in Mexican children.
abstract: BACKGROUND
  Low-grade chronic inflammation is a common feature of obesity and its cardio-metabolic complications. However, little is known about a possible causal role of inflammation in metabolic disorders. Mexico is among the countries with the highest obesity rates in the world and the admixed Mexican population is a relevant sample due to high levels of genetic diversity.
  
  
  METHODS
  Here, we studied 1,462 Mexican children recruited from Mexico City. Six genetic variants in five inflammation-related genes were genotyped: rs1137101 (leptin receptor (LEPR)), rs7305618 (hepatocyte nuclear factor 1 alpha (HNF1A)), rs1800629 (tumor necrosis factor alpha (TNFA)), rs1800896, rs1800871 (interleukin-10 (IL-10)), rs1862513 (resistin (RETN)). Ten continuous and eight binary traits were assessed. Linear and logistic regression models were used adjusting for age, sex, and recruitment centre.
  
  
  RESULTS
  We found that one SNP displayed a nominal evidence of association with a continuous trait: rs1800871 (IL-10) with LDL (beta = -0.068 ± 1.006, P = 0.01). Subsequently, we found one nominal association with a binary trait: rs7305618 (HNF1A) with family history of hypertension (odds-ratio = 1.389 [1.054-1.829], P = 0.02). However, no P-value passed the Bonferroni correction for multiple testing.
  
  
  CONCLUSIONS
  Our data in a Mexican children population are consistent with previous reports in European adults in failing to demonstrate an association between inflammation-associated single nucleotide polymorphisms (SNPs) and metabolic traits.
authors.affiliation: Clinical Epidemiology & Biostatistics, McMaster University , Hamilton , Canada.
authors.forename: Neeti
authors.initials: N
authors.lastname: Vashi
authors.affiliation: Clinical Epidemiology & Biostatistics, McMaster University , Hamilton , Canada.
authors.forename: Carolina
authors.initials: C
authors.lastname: Stryjecki
authors.affiliation: Medical Research Unit in Biochemistry, Hospital de Especialidades, Centro Médico Nacional Siglo XXI del Instituto Mexicano del Seguro Social , Mexico City , Mexico.
authors.forename: Jesus
authors.initials: J
authors.lastname: Peralta-Romero
authors.affiliation: Medical Research Unit in Biochemistry, Hospital de Especialidades, Centro Médico Nacional Siglo XXI del Instituto Mexicano del Seguro Social , Mexico City , Mexico.
authors.forename: Fernando
authors.initials: F
authors.lastname: Suarez
authors.affiliation: Medical Research Unit in Biochemistry, Hospital de Especialidades, Centro Médico Nacional Siglo XXI del Instituto Mexicano del Seguro Social , Mexico City , Mexico.
authors.forename: Jaime
authors.initials: J
authors.lastname: Gomez-Zamudio
authors.affiliation: Centro de investigación sobre enfermedades infecciosas, Instituto Nacional de Salud Pública , Cuernavaca , Mexico.
authors.forename: Ana I
authors.initials: AI
authors.lastname: Burguete-Garcia
authors.affiliation: Medical Research Unit in Biochemistry, Hospital de Especialidades, Centro Médico Nacional Siglo XXI del Instituto Mexicano del Seguro Social , Mexico City , Mexico.
authors.forename: Miguel
authors.initials: M
authors.lastname: Cruz
authors.affiliation: Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Canada; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
authors.forename: David
authors.initials: D
authors.lastname: Meyre
keywords: Cardio-metabolic complications; Childhood; Genetic epidemiology; Inflammation; Mexico; Obesity