title: Olanzapine-Induced Malignant Neuroleptic Syndrome.
abstract: Neuroleptic malignant syndrome (NMS), caused by antipsychotic therapy, shows itself with mental status alteration, high fever, autonomic dysfunction, and muscle rigidity. It is a rare idiosyncratic reaction with mortality risk. The etiology is still unknown. NMS-related mortality and morbidity can be decreased by cessation of the used drug and aggressive treatment. Olanzapine is a thienobenzodiazepine, a member of atypical antipsychotic drugs; its structure and effects on neurotransmitters resemble clozapine. Here we report a case of bipolar disorder receiving olanzapine therapy for 10 years, who developed NMS without rigidity. We emphasized the importance of early hydration and hemodiafiltration therapy.
authors.affiliation: Department of Anaesthesiology and Reanimation, Necmettin Erbakan University Meram Faculty of Medicine, Konya, Turkey.
authors.forename: Tuba Berra
authors.initials: TB
authors.lastname: Sarıtaş
authors.affiliation: Clinic of Anaesthesiology and Reanimation, Dr. İ. Şevki Atasagun State Hospital, Nevşehir, Turkey.
authors.forename: Barış
authors.initials: B
authors.lastname: Çankaya
authors.affiliation: Department of Anaesthesiology and Reanimation, Necmettin Erbakan University Meram Faculty of Medicine, Konya, Turkey.
authors.forename: Alper
authors.initials: A
authors.lastname: Yosunkaya
keywords: Neuroleptic malignant syndrome; hemodiafiltration; olanzapine; rigidity