title: The Effects of Acute and Chronic Exercise on Skeletal Muscle Proteome.
abstract: Skeletal muscle plasticity and its adaptation to exercise is a topic that is widely discussed and investigated due to its primary role in the field of exercise performance and health promotion. Repetitive muscle contraction through exercise stimuli leads to improved cardiovascular output and the regulation of endothelial dysfunction and metabolic disorders such as insulin resistance and obesity. Considerable improvements in proteomic tools and data analysis have broth some new perspectives in the study of the molecular mechanisms underlying skeletal muscle adaptation in response to physical activity. In this sense, this review updates the main relevant studies concerning muscle proteome adaptation to acute and chronic exercise, from aerobic to resistance training, as well as the proteomic profile of natural inbred high running capacity animal models. Also, some promising prospects in the muscle secretome field are presented, in order to better understand the role of physical activity in the release of extracellular microvesicles and myokines activity. Thus, the present review aims to update the fast-growing exercise-proteomic scenario, leading to some new perspectives about the molecular events under skeletal muscle plasticity in response to physical activity. J. Cell. Physiol. 232: 257-269, 2017. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Centro Universit ário do Distrito Federal-UDF, Brasília-DF, Brasil. bernardopetriz@gmail.com.
authors.forename: Bernardo A
authors.initials: BA
authors.lastname: Petriz
authors.affiliation: Cardiovascular Research Unit, Luxembourg Institute of Health, Luxembourg, Luxembourg.
authors.forename: Clarissa P C
authors.initials: CP
authors.lastname: Gomes
authors.affiliation: Curso de Educação Física, Universidade Federal do Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brasil.|S-Inova Biotech, Universidade Cat ólica Dom Bosco, Campo Grande, Mato Grosso do Sul, Brasil.
authors.forename: Jeeser A
authors.initials: JA
authors.lastname: Almeida
authors.affiliation: Programa de Pós-Graduação em Patologia Molecular-Universidade de Brasília, DF, Brasil.
authors.forename: Getulio P
authors.initials: GP
authors.lastname: de Oliveira
authors.affiliation: Centro de Analises Proteomicas e Bioquímicas, Programa de P os-Graduacão em Ciências Genômicas e Biotecnologia, Universidade Cat ólica de Brasília, Brasília/DF, Brasil.
authors.forename: Filipe M
authors.initials: FM
authors.lastname: Ribeiro
authors.affiliation: Centro de Analises Proteomicas e Bioquímicas, Programa de P os-Graduacão em Ciências Genômicas e Biotecnologia, Universidade Cat ólica de Brasília, Brasília/DF, Brasil.
authors.forename: Rinaldo W
authors.initials: RW
authors.lastname: Pereira
authors.affiliation: S-Inova Biotech, Universidade Cat ólica Dom Bosco, Campo Grande, Mato Grosso do Sul, Brasil.|Centro de Analises Proteomicas e Bioquímicas, Programa de P os-Graduacão em Ciências Genômicas e Biotecnologia, Universidade Cat ólica de Brasília, Brasília/DF, Brasil.
authors.forename: Octavio L
authors.initials: OL
authors.lastname: Franco
mesh_terms: D015444:Exercise / Q000502:physiology*; D006801:Humans; D018482:Muscle, Skeletal / Q000378:metabolism*; D020543:Proteome / Q000378:metabolism*; D040901:Proteomics; D055070:Resistance Training; D012420:Running
chemical_list: D020543:Proteome