title: Proteomics of Plasmodium vivax malaria: new insights, progress and potential.
abstract: Plasmodium vivax has accounted for an enormous share of the global malaria burden in recent years, along with Plasmodium falciparum. The wide distribution of P. vivax and recent evidences of severe and complicated vivax malaria across several endemic regions of the world suggest that this disease may have been more overlooked than benign. While P. falciparum has been extensively studied, P. vivax has received limited research attention owing to its complex nature and absence of a continuous culture system.
  
  
  
  This review briefly describes the epidemiology of vivax malaria, analyzes challenges towards effective control and summarizes major insights provided by genomics and transcriptomics research in the area. Subsequently, the review provides a detailed description of the applications of proteomics in vivax malaria research, focusing on both host responses and parasite proteomics studies to understand P. vivax biology. Expert commentary: In recent years, proteomics technologies are being used effectively to understand P. vivax biology and the underlying pathogenesis. Technological advances in mass spectrometry configurations, multiomics investigations and emerging strategies such as targeted proteomics may also immensely aid in studying disease severity, improving existing diagnosis and identifying new drug and vaccine targets.
authors.affiliation: a Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, India
authors.forename: Apoorva
authors.initials: A
authors.lastname: Venkatesh
authors.affiliation: a Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, India
authors.forename: Sandip K
authors.initials: SK
authors.lastname: Patel
authors.affiliation: a Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, India
authors.forename: Sandipan
authors.initials: S
authors.lastname: Ray
authors.affiliation: b Department of Microbiology , T. N. Medical College and BYL Nair Hospital , Mumbai , India.
authors.forename: Jayanthi
authors.initials: J
authors.lastname: Shastri
authors.affiliation: c Department of Biochemistry , Grant Govt Medical College and Sir JJ Group of Hospitals , Mumbai , India.
authors.forename: Gangadhar
authors.initials: G
authors.lastname: Chatterjee
authors.affiliation: d Department of Medicine, Malaria Research Center , S.P. Medical College , Bikaner , India.
authors.forename: Sanjay K
authors.initials: SK
authors.lastname: Kochar
authors.affiliation: a Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, India
authors.forename: Swati
authors.initials: S
authors.lastname: Patankar
authors.affiliation: a Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, India
authors.forename: Sanjeeva
authors.initials: S
authors.lastname: Srivastava
mesh_terms: D023281:Genomics; D006801:Humans; D016778:Malaria, Falciparum / Q000235:genetics* / Q000469:parasitology; D016780:Malaria, Vivax / Q000235:genetics* / Q000469:parasitology; D013058:Mass Spectrometry; D010963:Plasmodium falciparum / Q000235:genetics / Q000472:pathogenicity; D010966:Plasmodium vivax / Q000235:genetics* / Q000472:pathogenicity; D020543:Proteome / Q000235:genetics*; D040901:Proteomics
chemical_list: D020543:Proteome
keywords: Vivax malaria; humoral responses; mass spectrometry; parasite proteome; protein arrays