title: Synthesis, characterization and pharmacological studies of copper complexes of flavone derivatives as potential anti-tuberculosis agents.
abstract: Novel series of different hydroxyflavone derivatives and their copper complexes were synthesized. They were characterized using analytical and spectral techniques. The superoxide dismutase (SOD) mimetic activity of the synthesized complexes demonstrated that copper complex of L(10) has promising SOD-mimetic activity than other ligands & complexes. The in vitro antimicrobial activities of the synthesized compounds were tested against the bacterial species and fungal species. The DNA binding properties of copper complexes were studied using cyclic voltametry and electronic absorption techniques. Anti-tuberculosis activity was also performed. The effective complexes was subjected to antimycobacterial activity using MABA method and summarized. The antimycobacterial activity of copper complexes have been evaluated and discussed.
authors.affiliation: Department of Chemistry, Noorul Islam Centre for Higher Education, Kumaracoil 629180, Tamilnadu, India. Electronic address: chem_joseph@yahoo.co.in.
authors.forename: J
authors.initials: J
authors.lastname: Joseph
authors.affiliation: Department of Chemistry, Noorul Islam Centre for Higher Education, Kumaracoil 629180, Tamilnadu, India.
authors.forename: K
authors.initials: K
authors.lastname: Nagashri
authors.affiliation: Department of Chemistry, Noorul Islam Centre for Higher Education, Kumaracoil 629180, Tamilnadu, India.
authors.forename: A
authors.initials: A
authors.lastname: Suman
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D003300:Copper / Q000737:chemistry*; D047309:Flavones / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D013057:Spectrum Analysis / Q000379:methods; D013818:Thermogravimetry
chemical_list: D000995:Antitubercular Agents; D047309:Flavones; D003300:Copper
keywords: Hydrogen peroxide; Hydroxyflavone; Superoxide dismutase