title: The Role of Drug Transporters in the Pharmacokinetics of Antibiotics.
abstract: BACKGROUND
  Various transporters, including efflux transporters and uptake transporters, play an important role in the pharmacokinetics of drugs. Currently, studies suggest that several antibiotics also serve as substrates for transporters. In addition, these antibiotics are usually combined with other drugs to treat diseases, more effectively. Therefore, it is necessary to focus on the role of transporters in pharmacokinetics and drug-drug interactions of antibiotics.
  
  
  METHODS
  This review summarizes the findings of recent studies as well as information retrieved from several databases (until June 2015): ISI Web of KnowledgeSM (ISI WoK), SciFinder (Caplus, Medline, Registry, Casreact, Chrmlist, and Chemcasts) and PubMed (indexed for Medline).
  
  
  RESULTS
  The present review provides useful information for the study of transporters in the pharmacokinetics and drug-drug interactions of antibiotics, and should assist researchers investigating these topics.
  
  
  CONCLUSIONS
  The drug transporters mediate intestinal absorption, hepatic uptake, and kidney or biliary excretion. It is necessary to focus on drug-drug interactions when these antibiotics are combined with other chemical substances that are also the substrates for transporters.
authors.affiliation: Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang, China. wenjh866@163.com.
authors.forename: Wen Jin
authors.initials: WJ
authors.lastname: Hua
authors.forename: Wei Xiao
authors.initials: WX
authors.lastname: Hua
authors.forename: Zhou
authors.initials: Z
authors.lastname: Jian
authors.forename: Peng Hong
authors.initials: PH
authors.lastname: Wei
authors.forename: Lu Yan
authors.initials: LY
authors.lastname: Ni
authors.forename: Li Yu
authors.initials: LY
authors.lastname: Hua
authors.forename: Cao Duan
authors.initials: CD
authors.lastname: Wen
authors.forename: Zhou
authors.initials: Z
authors.lastname: Ying
authors.affiliation: caol_nu@163.com.
authors.forename: Cao
authors.initials: C
authors.lastname: Li
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D004347:Drug Interactions; D006801:Humans; D026901:Membrane Transport Proteins / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D026901:Membrane Transport Proteins