title: Vesicle-MaNiA: extracellular vesicles in liquid biopsy and cancer.
abstract: Normal and tumor cells shed vesicles to the environment. Within the large family of extracellular vesicles, exosomes and microvesicles have attracted much attention in the recent years. Their interest ranges from mediators of cancer progression, inflammation, immune regulation and metastatic niche regulation, to non-invasive biomarkers of disease. In this respect, the procedures to purify and analyze extracellular vesicles have quickly evolved and represent a source of variability for data integration in the field. In this review, we provide an updated view of the potential of exosomes and microvesicles as biomarkers and the available technologies for their isolation.
authors.affiliation: CIC bioGUNE, Bizkaia Technology Park, 801ª bld., 48160 Derio, Bizkaia, Spain.
authors.forename: Veronica
authors.initials: V
authors.lastname: Torrano
authors.affiliation: CIC bioGUNE, Bizkaia Technology Park, 801ª bld., 48160 Derio, Bizkaia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain.
authors.forename: Felix
authors.initials: F
authors.lastname: Royo
authors.affiliation: Microenvironment and Metastasis Laboratory, Department of Molecular Oncology, Spanish National Cancer Research Center (CNIO), Madrid 28029, Spain.
authors.forename: Héctor
authors.initials: H
authors.lastname: Peinado
authors.affiliation: Department of Urology, Basurto University Hospital, 48013 Bilbao, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Loizaga-Iriarte
authors.affiliation: Department of Urology, Basurto University Hospital, 48013 Bilbao, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Unda
authors.affiliation: CIC bioGUNE, Bizkaia Technology Park, 801ª bld., 48160 Derio, Bizkaia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain; Ikerbasque, Basque Foundation for Science, 48011 Bilbao, Spain. Electronic address: jfalcon@cicbiogune.es.
authors.forename: Juan M
authors.initials: JM
authors.lastname: Falcón-Perez
authors.affiliation: CIC bioGUNE, Bizkaia Technology Park, 801ª bld., 48160 Derio, Bizkaia, Spain; Ikerbasque, Basque Foundation for Science, 48011 Bilbao, Spain; Biochemistry and Molecular Biology Department, University of the Basque Country (UPV/EHU), P.O. Box 644, E-48080 Bilbao, Spain. Electronic address: acarracedo@cicbiogune.es.
authors.forename: Arkaitz
authors.initials: A
authors.lastname: Carracedo
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D001706:Biopsy / Q000379:methods; D055252:Cell-Derived Microparticles / Q000378:metabolism; D018450:Disease Progression; D055354:Exosomes / Q000378:metabolism*; D000067128:Extracellular Vesicles / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000473:pathology; D009369:Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor