title: Cytokine Therapies in Neurological Disease.
abstract: Cytokines are a heterogeneous group of glycoproteins that coordinate physiological functions. Cytokine deregulation is observed in many neurological diseases. This article reviews current research focused on human clinical trials of cytokine and anticytokine therapies in the treatment of several neurological disease including stroke, neuromuscular diseases, neuroinfectious diseases, demyelinating diseases, and neurobehavioral diseases. This research suggests that cytokine therapy applications may play an important role in offering new strategies for disease modulation and treatment. Further, this research provides insights into the causal link between cytokine deregulation and neurological diseases.
authors.affiliation: Viral Immunology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA.
authors.forename: Shila
authors.identifier: 0000-0002-8884-3525
authors.initials: S
authors.lastname: Azodi
authors.affiliation: Viral Immunology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA. jacobsons@ninds.nih.gov.
authors.forename: Steven
authors.initials: S
authors.lastname: Jacobson
mesh_terms: D000544:Alzheimer Disease / Q000150:complications / Q000188:drug therapy; D000818:Animals; D002986:Clinical Trials as Topic; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000627:therapeutic use*; D003711:Demyelinating Diseases / Q000150:complications / Q000188:drug therapy; D004660:Encephalitis / Q000150:complications / Q000188:drug therapy; D006801:Humans; D009103:Multiple Sclerosis / Q000150:complications / Q000188:drug therapy; D009422:Nervous System Diseases / Q000150:complications / Q000188:drug therapy*; D009468:Neuromuscular Diseases / Q000150:complications / Q000188:drug therapy; D020521:Stroke / Q000150:complications / Q000188:drug therapy; D016896:Treatment Outcome
chemical_list: D016207:Cytokines
keywords: Cytokine; anticytokine; drug development.; neurology