title: Complicated community acquired pneumonia in childhood: Different types, clinical course, and outcome.
abstract: The incidence of pediatric community acquired complicated pneumonia (PCACP) is increasing. Questions addressed: Are different types of PCACP one disease? How do different treatment protocols affect the outcome?
  
  
  
  Retrospective analysis of medical records of PCACP hospitalizations in the three major hospitals in Jerusalem in the years 2001-2010 for demographics, clinical presentation, management, and outcome.
  
  
  
  Of the 144 children (51% aged 1-4 years), 91% of Jewish origin; 40% had para-pneumonic effusion (PPE), 40% empyema (EMP), and 20% necrotizing pneumonia (NP). Bacterial origin was identified in 42% (empyema 79%, P = 0.009), most common S. pneumoniae (32%), group A streptococcus (9%). Patients with EMP, compared to PPE and NP, were less likely to receive prior antibiotic treatment (35% vs. 57% and 59%, respectively, P = 0.04). Mean hospitalization was longer in patients with NP followed by EMP and PPE (16.4 ± 10.6, 15.2 ± 7.9, and 12.7 ± 4.7 days, respectively), use of fibrinolysis was not associated with the outcome. All children had recovered to discharge regardless of antibiotic therapy or fibrinolysis.
  
  
  
  NP is a more severe disease with prolonged morbidity and hospitalization in spite of prior antibiotic treatment. All types had favorable outcome regardless of treatment-protocol. Complicated pneumonia has an ethnic predominance. Pediatr Pulmonol. 2017;52:247-254. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Department of Pediatrics, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
authors.forename: Ira
authors.initials: I
authors.lastname: Erlichman
authors.affiliation: Pediatric Pulmonology Unit, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
authors.forename: Oded
authors.initials: O
authors.lastname: Breuer
authors.affiliation: Pediatric Pulmonology Unit, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
authors.forename: David
authors.initials: D
authors.lastname: Shoseyov
authors.affiliation: Pediatric Pulmonology Unit, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
authors.forename: Malena
authors.initials: M
authors.lastname: Cohen-Cymberknoh
authors.affiliation: Pediatric Radiology Unit, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Koplewitz
authors.affiliation: Pediatric Infectious Disease Unit, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
authors.forename: Diana
authors.initials: D
authors.lastname: Averbuch
authors.affiliation: Department of Pediatric Emergency Medicine, Shaare Zedek Medical Center, Jerusalem, Israel.
authors.forename: Matti
authors.initials: M
authors.lastname: Erlichman
authors.affiliation: Pediatric Pulmonology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
authors.forename: Elie
authors.initials: E
authors.lastname: Picard
authors.affiliation: Pediatric Pulmonology Unit, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
authors.forename: Eitan
authors.initials: E
authors.lastname: Kerem
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D017714:Community-Acquired Infections / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D016724:Empyema, Pleural / Q000209:etiology; D005260:Female; D006760:Hospitalization; D006801:Humans; D015994:Incidence; D007223:Infant; D007557:Israel; D008297:Male; D010996:Pleural Effusion / Q000209:etiology; D011014:Pneumonia / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D000071067:Pneumonia, Necrotizing / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D011018:Pneumonia, Pneumococcal / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D012189:Retrospective Studies; D013290:Streptococcal Infections / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D013296:Streptococcus pneumoniae; D013297:Streptococcus pyogenes; D015996:Survival Rate
chemical_list: D000900:Anti-Bacterial Agents
keywords: empyema; necrotizing pneumonia; para-pneumonic effusion; pediatric community acquired complicated pneumonia