title: [Atrial Septal Defect with Hereditary Deficiency of Antithrombin III].
abstract: A 41-year-old female with hereditary deficiency of antithrombin III (ATIII) was diagnosed with atrial septal defect( ASD) and scheduled for the closure of ASD. She had been taking warfarin since she suffered from deep vein thrombosis 10 years ago. Preoperative management of anticoagulation included discontinuation of warfarin, and supplementation of antithrombin with heparin infusion. On the day of operation, antithrombin activity was maintained above 80% by administering antithrombin, and closure of ASD was carried out under standard cardiopulmonary bypass support using heparin. Heparin infusion was continued with antithrombin supplementation until prothrombin time-international normalized ratio(PT-INR) recovered to around 2.5 with warfarin. Her intra-and postoperative courses did not show any thromboembolic events, and she was discharged 20 days after the surgery.
authors.affiliation: Department of Cardiac Surgery, Jikei University School of Medicine, Tokyo, Japan.
authors.forename: Hitomi
authors.initials: H
authors.lastname: Naruse
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Sakamoto
authors.forename: Katsushi
authors.initials: K
authors.lastname: Kinouchi
authors.forename: Takahiro
authors.initials: T
authors.lastname: Inoue
authors.forename: Yoko
authors.initials: Y
authors.lastname: Matsumura
authors.forename: Michio
authors.initials: M
authors.lastname: Yoshitake
authors.forename: Ko
authors.initials: K
authors.lastname: Bando
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Hashimoto
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage*; D000990:Antithrombin III / Q000008:administration & dosage; D020152:Antithrombin III Deficiency / Q000151:congenital*; D006348:Cardiac Surgical Procedures; D005260:Female; D006344:Heart Septal Defects, Atrial / Q000601:surgery*; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D019934:International Normalized Ratio; D011183:Postoperative Complications / Q000517:prevention & control*; D011300:Preoperative Care / Q000379:methods*; D013918:Thrombin Time; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000517:prevention & control*; D014859:Warfarin / Q000008:administration & dosage
chemical_list: D000925:Anticoagulants; D014859:Warfarin; D000990:Antithrombin III; D006493:Heparin