title: Efficacy of Methylprednisolone Pulse Followed by Oral Prednisone in Birdshot Chorioretinopathy.
abstract: OBJECTIVE
  To report the outcomes of initial methylprednisolone pulse then oral prednisone in the treatment of birdshot chorioretinopathy (BSCR).
  
  
  METHODS
  We retrospectively reviewed medical records of 21 BSCR patients, treated with initial methylprednisolone, prednisone, or immunosuppressive therapy. Main outcome measures were changes in visual acuity, intraocular inflammation, concomitant immunosuppressive drug or intravitreal steroid, and adverse events.
  
  
  RESULTS
  In total, 14 patients were initially treated with methylprednisolone; four patients with prednisone; and three with immunosuppressive drug. Intraocular inflammation was controlled in 10 of 14 patients (71%) at 1 year, with a mean dose of 6.2 mg/day prednisone. Patients treated initially by methylprednisolone had improved visual acuity at 1 year, but it was not significantly different from patients treated initially by prednisone.
  
  
  CONCLUSIONS
  Corticosteroid therapy, including initial methylprednisolone pulse then prednisone, was effective in stabilizing vision and decreasing inflammation in most patients with BSCR.
authors.affiliation: a Ophthalmology Department, Hôpital de la Croix-Rousse , Hospices Civils de Lyon, Quai des Célestins , Lyon , France.
authors.forename: Meriem
authors.initials: M
authors.lastname: Hafidi
authors.affiliation: a Ophthalmology Department, Hôpital de la Croix-Rousse , Hospices Civils de Lyon, Quai des Célestins , Lyon , France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Loria
authors.affiliation: a Ophthalmology Department, Hôpital de la Croix-Rousse , Hospices Civils de Lyon, Quai des Célestins , Lyon , France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Kodjikian
authors.affiliation: a Ophthalmology Department, Hôpital de la Croix-Rousse , Hospices Civils de Lyon, Quai des Célestins , Lyon , France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Denis
authors.affiliation: b Biostatistics Department , Université Claude Bernard Lyon I , Lyon , France.
authors.forename: Muriel R
authors.initials: MR
authors.lastname: Ferrand
authors.affiliation: c Internal Medicine Department, Hôpital de la Croix-Rousse , Hospices Civils de Lyon, Quai des Célestins , Lyon , France.
authors.forename: Christiane
authors.initials: C
authors.lastname: Broussolle
authors.affiliation: c Internal Medicine Department, Hôpital de la Croix-Rousse , Hospices Civils de Lyon, Quai des Célestins , Lyon , France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Sève
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000080365:Birdshot Chorioretinopathy; D002825:Chorioretinitis / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use*; D020551:Pulse Therapy, Drug; D012189:Retrospective Studies; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology
chemical_list: D004338:Drug Combinations; D005938:Glucocorticoids; D011241:Prednisone; D008775:Methylprednisolone
keywords: Birdshot chorioretinopathy; methylprednisolone; prednisone; pulse; uveitis