title: Topotactic Conversion of Copper(I) Phosphide Nanowires for Sensitive Electrochemical Detection of H2O2 Release from Living Cells.
abstract: In this work, we clearly demonstrate for the first time the use of transition-metal phosphides to set up a new cathodic analysis platform for sensitive and selective electrochemical nonenzymatic detection of H2O2. With the help of a facile topotactic conversion method, the noble metal-free electrocatalyst of copper(I) phosphide nanowires on three-dimensional porous copper foam (Cu3P NWs/CF) is fabricated with electrochemical anodized Cu(OH)2 NWs as precursor. The Cu3P NWs/CF-based sensor presents excellent electrocatalytic activity for H2O2 reduction with a detection limit of 2 nM, the lowest detection limit achieved by noble-metal free electrocatalyst, which guarantees the possibility of sensitive and reliable detection of H2O2 release from living tumorigenic cells, thus showing the potential application as a sensitive cancer cell detection probe.
authors.affiliation: School of Chemistry and Molecular Engineering, East China Normal University , 500 Dongchuan Road, Shanghai 200241, China.
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Li
authors.affiliation: School of Chemistry and Molecular Engineering, East China Normal University , 500 Dongchuan Road, Shanghai 200241, China.
authors.forename: Yanmei
authors.initials: Y
authors.lastname: Xin
authors.affiliation: School of Chemistry and Molecular Engineering, East China Normal University , 500 Dongchuan Road, Shanghai 200241, China.
authors.forename: Wenlong
authors.initials: W
authors.lastname: Wu
authors.affiliation: School of Chemistry and Molecular Engineering, East China Normal University , 500 Dongchuan Road, Shanghai 200241, China.
authors.forename: Baihe
authors.initials: B
authors.lastname: Fu
authors.affiliation: School of Chemistry and Molecular Engineering, East China Normal University , 500 Dongchuan Road, Shanghai 200241, China.
authors.forename: Zhonghai
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D004298:Dopamine / Q000032:analysis; D055664:Electrochemical Techniques; D004566:Electrodes; D005947:Glucose / Q000032:analysis; D006861:Hydrogen Peroxide / Q000032:analysis*; D057230:Limit of Detection; D051379:Mice; D053770:Nanowires / Q000737:chemistry*; D016062:Porosity; D000067996:RAW 264.7 Cells
chemical_list: D003300:Copper; D006861:Hydrogen Peroxide; D005947:Glucose; D004298:Dopamine