title: Study of the Effect of Dillenia indica Fruit Mucilage on the Properties of Metformin Hydrochloride Loaded Spray Dried Microspheres.
abstract: Natural materials are preferred over synthetic counterparts because of their biodegradable and biocompatible nature. The present work was proposed to utilize mucilage from natural source for the development of controlled release formulation of metformin hydrochloride. Natural mucilaginous substance extracted from Dillenia indica L. (DI) fruit was used in fabricating controlled release microspheres. The microspheres were prepared by spray drying method under different formulation parameters. The prepared microspheres were studied for particle size, drug excipient compatibility, particle shape and surface morphologies, drug entrapment efficiency, mucoadhesivity, and in vitro drug release properties. The prepared microspheres exhibited mucoadhesive properties and demonstrated controlled release of metformin hydrochloride. The study reveals that the natural materials can be used for formulation of controlled release microspheres and would provide ample opportunities for further study.
authors.affiliation: Department of Pharmaceutical Sciences, Dibrugarh University, NH-37, Dibrugarh, Assam 786004, India.
authors.forename: Hemanta Kumar
authors.initials: HK
authors.lastname: Sharma
authors.affiliation: Department of Pharmaceutical Sciences, Dibrugarh University, NH-37, Dibrugarh, Assam 786004, India.
authors.forename: Lila Kanta
authors.initials: LK
authors.lastname: Nath