title: Periodontitis May Deteriorate Sinus of Valsalva Dilatation in Marfan Syndrome Patients.
abstract: Marfan syndrome (MFS) is a systemic connective tissue disorder that is caused by mutations of fibrillin-1. While MFS patients are at a high risk of periodontitis and aortic diseases, little causal information has been provided to date. To clarify the relationship, their oral condition and sinus of Valsalva (SoV) were evaluated.The subjects were patients with MFS (n = 33) who attended the University of Tokyo Hospital. We divided them into two groups; MFS patients with highly dilated (the diameters were equal to or more than 39 mm) SoV (high group, n = 18) and MFS patients with mildly dilated (less than 39 mm) SoV (mild group, n = 15). Blood examinations, echocardiograms, and full-mouth clinical measurements, including number of teeth, probing pocket depth (PPD), bleeding on probing (BOP), and community periodontal index (CPI) were performed.We found that the high group patients had greater rates of BOP compared to that of the mild group. Furthermore, the high group tended to have higher serum levels of C-reactive protein, matrix metalloproteinase-9, and transforming growth factor-β compared to the mild group.Periodontitis may deteriorate SoV dilatation in MFS patients.
authors.affiliation: Department of Advanced Clinical Science and Therapeutics, The University of Tokyo.
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Suzuki
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Imai
authors.forename: Mieko
authors.initials: M
authors.lastname: Aoki
authors.forename: Daishi
authors.initials: D
authors.lastname: Fujita
authors.forename: Norifumi
authors.initials: N
authors.lastname: Takeda
authors.forename: Norio
authors.initials: N
authors.lastname: Aoyama
authors.forename: Kouji
authors.initials: K
authors.lastname: Wakayama
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Ikeda
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Kumagai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Akazawa
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Izumi
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Isobe
authors.forename: Issei
authors.initials: I
authors.lastname: Komuro
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Hirata
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D004108:Dilatation, Pathologic / Q000473:pathology; D005260:Female; D006785:Hospitals, University; D006801:Humans; D007564:Japan; D008297:Male; D008382:Marfan Syndrome / Q000150:complications*; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D010512:Periodontal Index; D010518:Periodontitis / Q000097:blood / Q000150:complications* / Q000175:diagnosis*; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D012850:Sinus of Valsalva / Q000000981:diagnostic imaging / Q000473:pathology*; D016212:Transforming Growth Factor beta / Q000097:blood*
chemical_list: D015415:Biomarkers; D016212:Transforming Growth Factor beta; D002097:C-Reactive Protein; D020780:Matrix Metalloproteinase 9