title: Orthostatic hypotension: pathophysiology, assessment, treatment and the paradox of supine hypertension.
abstract: Both hypertension and orthostatic hypotension (OH) are strongly age-associated and are common management problems in older people. However, unlike hypertension, management of OH has unique challenges with few well-established treatments. Not infrequently, they both coexist, further compounding the management. This review provides comprehensive information on OH, including pathophysiology, diagnostic workup and treatment, with a view to provide a practical guide to its management. Special references are made to patients with supine hypertension and postprandial hypotension and older hypertensive patients.
authors.affiliation: Eastern Health, The University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: Peter
authors.initials: P
authors.lastname: Chisholm
authors.affiliation: Eastern Health, The University of Melbourne, Melbourne, Victoria, Australia.|North West Academic Centre, Department of Medicine, The University of Melbourne, Melbourne, Victoria, Australia.|Department of Medicine, Monash University, Melbourne, Victoria, Australia.
authors.forename: Mahesan
authors.initials: M
authors.lastname: Anpalahan
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use; D000978:Antiparkinson Agents / Q000627:therapeutic use; D003000:Clonidine / Q000627:therapeutic use; D019468:Disease Management; D004294:Domperidone / Q000627:therapeutic use; D018492:Dopamine Antagonists / Q000627:therapeutic use; D015103:Droxidopa / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D007024:Hypotension, Orthostatic / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D011446:Prospective Studies; D016683:Supine Position / Q000502:physiology*
chemical_list: D000959:Antihypertensive Agents; D000978:Antiparkinson Agents; D018492:Dopamine Antagonists; D007166:Immunosuppressive Agents; D004294:Domperidone; D015103:Droxidopa; D003000:Clonidine
keywords: nocturnal hypertension; orthostatic hypotension; orthostatic intolerance; supine hypertension; syncope