title: Successful Use of Four Factor-Prothrombin Complex Concentrate for Congenital Factor X Deficiency in the Setting of Neurosurgery.
abstract: Congenital factor X deficiency is an extremely rare coagulation disorder that can place patients at risk for spontaneous hemorrhage or excessive bleeding in the setting of trauma or invasive procedures. Given the rarity of this disorder, there is little published guidance on how best to prevent or treat bleeding. Herein, we report a case of a 56-year-old white man with congenital factor X deficiency who was scheduled for major neurosurgery and who was treated perioperatively with 4-factor prothrombin complex concentrate (4F-PCC). Doses of 4F-PCC at 15 U per kg, administered immediately preoperatively and once at 24 hours postoperatively, allowed for successful completion of an anterior cervical discectomy and fusion without excessive bleeding. Moreover, no thromboembolic complications were observed. As such, given the wide availability of 4F-PCC, it may be considered as a first-line therapy and an alternative to fresh frozen plasma for factor X deficiencies, particularly in high-risk operative cases.
authors.affiliation: Pathology & Laboratory Medicine Service, VA Connecticut Healthcare System, West Haven, CT, USA Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Alexa J
authors.initials: AJ
authors.lastname: Siddon
authors.affiliation: Pathology & Laboratory Medicine Service, VA Connecticut Healthcare System, West Haven, CT, USA Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA christopher.tormey@yale.edu.
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Tormey
mesh_terms: D001779:Blood Coagulation Factors / Q000008:administration & dosage*; D017586:Diskectomy; D005171:Factor X Deficiency / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009493:Neurosurgery; D011182:Postoperative Care / Q000379:methods*; D011300:Preoperative Care / Q000379:methods*; D013123:Spinal Fusion; D016896:Treatment Outcome
chemical_list: D001779:Blood Coagulation Factors; C025667:prothrombin complex concentrates
keywords: Congenital factor X deficiency; blood banking; coagulation; neurosurgery; prothrombin complex concentrate; transfusion medicine