title: Ribosomal Antibiotics: Contemporary Challenges.
abstract: Most ribosomal antibiotics obstruct distinct ribosomal functions. In selected cases, in addition to paralyzing vital ribosomal tasks, some ribosomal antibiotics are involved in cellular regulation. Owing to the global rapid increase in the appearance of multi-drug resistance in pathogenic bacterial strains, and to the extremely slow progress in developing new antibiotics worldwide, it seems that, in addition to the traditional attempts at improving current antibiotics and the intensive screening for additional natural compounds, this field should undergo substantial conceptual revision. Here, we highlight several contemporary issues, including challenging the common preference of broad-range antibiotics; the marginal attention to alterations in the microbiome population resulting from antibiotics usage, and the insufficient awareness of ecological and environmental aspects of antibiotics usage. We also highlight recent advances in the identification of species-specific structural motifs that may be exploited for the design and the creation of novel, environmental friendly, degradable, antibiotic types, with a better distinction between pathogens and useful bacterial species in the microbiome. Thus, these studies are leading towards the design of "pathogen-specific antibiotics," in contrast to the current preference of broad range antibiotics, partially because it requires significant efforts in speeding up the discovery of the unique species motifs as well as the clinical pathogen identification.
authors.affiliation: Department of Structural Biology, Weizmann Institute, Rehovot 76100, Israel. tauerba@its.jnj.com.
authors.forename: Tamar
authors.initials: T
authors.lastname: Auerbach-Nevo
authors.affiliation: Department of Structural Biology, Weizmann Institute, Rehovot 76100, Israel. david@smzyme.com.
authors.forename: David
authors.initials: D
authors.lastname: Baram
authors.affiliation: Department of Structural Biology, Weizmann Institute, Rehovot 76100, Israel. anat.bashan@weizmann.ac.il.
authors.forename: Anat
authors.initials: A
authors.lastname: Bashan
authors.affiliation: Department of Structural Biology, Weizmann Institute, Rehovot 76100, Israel. matthew.belousoff@monash.edu.
authors.forename: Matthew
authors.initials: M
authors.lastname: Belousoff
authors.affiliation: Department of Structural Biology, Weizmann Institute, Rehovot 76100, Israel. elinor.breiner@weizmann.ac.il.
authors.forename: Elinor
authors.initials: E
authors.lastname: Breiner
authors.affiliation: Department of Structural Biology, Weizmann Institute, Rehovot 76100, Israel. Chen.Davidovich@monash.edu.
authors.forename: Chen
authors.initials: C
authors.lastname: Davidovich
authors.affiliation: Department of Structural Biology, Weizmann Institute, Rehovot 76100, Israel. giuseppe.cimicata@gmail.com.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Cimicata
authors.affiliation: Department of Structural Biology, Weizmann Institute, Rehovot 76100, Israel. zohar.baram@weizmann.ac.il.
authors.forename: Zohar
authors.initials: Z
authors.lastname: Eyal
authors.affiliation: Department of Structural Biology, Weizmann Institute, Rehovot 76100, Israel. Yehuda.Halfon@weizmann.ac.il.
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Halfon
authors.affiliation: Department of Structural Biology, Weizmann Institute, Rehovot 76100, Israel. Miri.Krupkin@weizmann.ac.il.
authors.forename: Miri
authors.initials: M
authors.lastname: Krupkin
authors.affiliation: Department of Structural Biology, Weizmann Institute, Rehovot 76100, Israel. Matzov.donna@weizmann.ac.il.
authors.forename: Donna
authors.initials: D
authors.lastname: Matzov
authors.affiliation: Department of Structural Biology, Weizmann Institute, Rehovot 76100, Israel. markusmetz.at@gmail.com.
authors.forename: Markus
authors.initials: M
authors.lastname: Metz
authors.affiliation: Department of Structural Biology, Weizmann Institute, Rehovot 76100, Israel. Rufayda.Mruwat@weizmann.ac.il.
authors.forename: Mruwat
authors.initials: M
authors.lastname: Rufayda
authors.affiliation: Department of Structural Biology, Weizmann Institute, Rehovot 76100, Israel. moshe.peretz@weizmann.ac.il.
authors.forename: Moshe
authors.initials: M
authors.lastname: Peretz
authors.affiliation: Department of Structural Biology, Weizmann Institute, Rehovot 76100, Israel. ophir.pick@gmail.com.
authors.forename: Ophir
authors.initials: O
authors.lastname: Pick
authors.affiliation: Department of Structural Biology, Weizmann Institute, Rehovot 76100, Israel. erezpy@gmail.com.
authors.forename: Erez
authors.initials: E
authors.lastname: Pyetan
authors.affiliation: Department of Structural Biology, Weizmann Institute, Rehovot 76100, Israel. Haim.Rozenberg@weizmann.ac.il.
authors.forename: Haim
authors.initials: H
authors.lastname: Rozenberg
authors.affiliation: Department of Structural Biology, Weizmann Institute, Rehovot 76100, Israel. benami.moran@gmail.com.
authors.forename: Moran
authors.initials: M
authors.lastname: Shalev-Benami
authors.affiliation: Department of Structural Biology, Weizmann Institute, Rehovot 76100, Israel. Itai.Wekselman@weizmann.ac.il.
authors.forename: Itai
authors.initials: I
authors.lastname: Wekselman
authors.affiliation: Department of Structural Biology, Weizmann Institute, Rehovot 76100, Israel. zarivach@bgu.ac.il.
authors.forename: Raz
authors.initials: R
authors.lastname: Zarivach
authors.affiliation: Department of Structural Biology, Weizmann Institute, Rehovot 76100, Israel. Ella.Zimmerman@weizmann.ac.il.
authors.forename: Ella
authors.initials: E
authors.lastname: Zimmerman
authors.affiliation: Department of Structural Biology, Weizmann Institute, Rehovot 76100, Israel. nofar.assis@gmail.com.
authors.forename: Nofar
authors.initials: N
authors.lastname: Assis
authors.affiliation: Department of Structural Biology, Weizmann Institute, Rehovot 76100, Israel. joel.bloch@mol.biol.ethz.ch.
authors.forename: Joel
authors.initials: J
authors.lastname: Bloch
authors.affiliation: Department of Structural Biology, Weizmann Institute, Rehovot 76100, Israel. hadarisr@bgu.ac.il.
authors.forename: Hadar
authors.initials: H
authors.lastname: Israeli
authors.affiliation: Department of Structural Biology, Weizmann Institute, Rehovot 76100, Israel. rinat.kalaora@gmail.com.
authors.forename: Rinat
authors.initials: R
authors.lastname: Kalaora
authors.affiliation: Department of Structural Biology, Weizmann Institute, Rehovot 76100, Israel. lishaqjl@gmail.com.
authors.forename: Lisha
authors.initials: L
authors.lastname: Lim
authors.affiliation: Department of Structural Biology, Weizmann Institute, Rehovot 76100, Israel. ofir.sadefalk@gmail.com.
authors.forename: Ofir
authors.initials: O
authors.lastname: Sade-Falk
authors.affiliation: Department of Structural Biology, Weizmann Institute, Rehovot 76100, Israel. Tal.Shapira@weizmann.ac.il.
authors.forename: Tal
authors.initials: T
authors.lastname: Shapira
authors.affiliation: Department of Structural Biology, Weizmann Institute, Rehovot 76100, Israel. Leena.ta.salaime@gmail.com.
authors.forename: Leena
authors.initials: L
authors.lastname: Taha-Salaime
authors.affiliation: Department of Structural Biology, Weizmann Institute, Rehovot 76100, Israel. hua2han2003@yahoo.com.
authors.forename: Hua
authors.initials: H
authors.lastname: Tang
authors.affiliation: Department of Structural Biology, Weizmann Institute, Rehovot 76100, Israel. Ada.Yonath@weizmann.ac.il.
authors.forename: Ada
authors.initials: A
authors.lastname: Yonath
keywords: microbiome; multi-drug resistance; novel degradable antibiotics; species-specific antibiotics susceptibility