title: Asian Consensus Guidelines for the Diagnosis and Management of Gastrointestinal Stromal Tumor.
abstract: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors originating in the gastrointestinal tract. With the introduction of molecular-targeted therapy for GISTs which has yielded remarkable outcomes, these tumors have become a model of multidisciplinary oncological treatment. Although Western clinical guidelines are available for GISTs, such as those published by the National Comprehensive Cancer Network (NCCN) and the European Society of Medical Oncology (ESMO), the clinical situations in Asian countries are different from those in Western countries in terms of diagnostic methods, surgical approach, and availability of new targeted agents. Accordingly, we have reviewed current versions of several GIST guidelines published by Asian countries (Japan, Korea, China, and Taiwan) and the NCCN and ESMO and discussed the areas of dissensus. We here present the first version of the Asian GIST consensus guidelines that were prepared through a series of meetings involving multidisciplinary experts in the four countries. These guidelines provide an optimal approach to the diagnosis and management of GIST patients in Asian countries.
authors.affiliation: Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.|Korean GIST Study Group, Seoul, Korea.
authors.forename: Dong-Hoe
authors.initials: DH
authors.lastname: Koo
authors.affiliation: Korean GIST Study Group, Seoul, Korea.|Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Min-Hee
authors.initials: MH
authors.lastname: Ryu
authors.affiliation: Korean GIST Study Group, Seoul, Korea.|Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Kyoung-Mee
authors.initials: KM
authors.lastname: Kim
authors.affiliation: Korean GIST Study Group, Seoul, Korea.|Department of Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Han-Kwang
authors.initials: HK
authors.lastname: Yang
authors.affiliation: Department of Gastroenterology, Japanese Red Cross Nagoya Daini Hospital, Nagoya, Japan.|Japanese GIST Subcommittee, Nishinomiya, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Sawaki
authors.affiliation: Japanese GIST Subcommittee, Nishinomiya, Japan.|Department of Pathology, Hyogo College of Medicine, Nishinomiya, Japan.
authors.forename: Seiichi
authors.initials: S
authors.lastname: Hirota
authors.affiliation: Department of Pathology, Peking University Third Hospital, Beijing, China.|Chinese Expert Committee on GIST, Sichuan, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zheng
authors.affiliation: Chinese Expert Committee on GIST, Sichuan, China.|Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Sichuan, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Department of Pathology and Laboratory Medicine, Cathay General Hospital, Taipei, Taiwan.
authors.forename: Chin-Yuan
authors.initials: CY
authors.lastname: Tzen
authors.affiliation: Department of Surgery, Chang Gung Memorial Hospital and University, Taoyuan, Taiwan.
authors.forename: Chun-Nan
authors.initials: CN
authors.lastname: Yeh
authors.affiliation: Japanese GIST Subcommittee, Nishinomiya, Japan.|Department of Surgery, National Cancer Center Hospital East, Chiba, Japan.
authors.forename: Toshirou
authors.initials: T
authors.lastname: Nishida
authors.affiliation: Chinese Expert Committee on GIST, Sichuan, China.|Department of Gastrointestinal Oncology, Peking University Cancer Hospital & Institute, Beijing, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Shen
authors.affiliation: National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan.|Department of Internal Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Li-Tzong
authors.initials: LT
authors.lastname: Chen
authors.affiliation: Korean GIST Study Group, Seoul, Korea.|Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Yoon-Koo
authors.initials: YK
authors.lastname: Kang
mesh_terms: D044466:Asian People / Q000235:genetics; D002681:China; D032921:Consensus; D019468:Disease Management; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D017408:Guidelines as Topic; D006801:Humans; D058990:Molecular Targeted Therapy; D056910:Republic of Korea; D013624:Taiwan
keywords: Gastrointestinal stromal tumors; Guideline; Imatinib mesylate; Regorafenib; Sunitinib