title: [Sensitivity of microbial associations of periodontal lesions to antibacterial agents].
abstract: The aim of the study was the development of approaches to improve the effectiveness of antibiotic therapy in dental practice on the basis of determining the sensitivity of pathogenic microorganisms to antibiotics of different groups.
  
  
  METHODS
  The study included determination of the sensitivity of the microbial complexes from wound exudate of periodontal pocket and apical abscess to macrolides, quinolones, penicillins, lincosamides and 5-nitroimidazole. A survey of dentists and dental clinics patients to identify the cause and frequency of use of antibiotics and to identify possible adverse reactions was also conducted.
  
  
  RESULTS
  Dentists prefer macrolide antibiotics, protected penicillins, and fluoroquinolone combined with 5-nitroimidazole. All patients have taken antibiotics themselves at least once a year. Microbial complexes in patients with acute and exacerbated apical periodontitis in 79% of cases are susceptible to amoxicillin/clavulanic acid, to azithromycin - 52%, lincomycin - 36%, 5-nitroimidazole - 68%, ciprofloxacin - 73.7%. In patients with apical abscess high rates of resistance of microbial complexes to all types of antibiotics was revealed (33% for lincomycin 76,1% for ciprofloxacin, 28,6% for 5-nitroimidazole). Patients with moderate to severe periodontitis in 90.5% are sensitive to amoxicillin/clavulanic acid and azithromycin, in 62.4% to lincomycin. Sensitivity to ciprofloxacin was detected in 85.7% of patients, in 14.3% - moderate resistance.
authors.affiliation: First Moscow State Medical University, Moscow, Russia.
authors.forename: I M
authors.initials: IM
authors.lastname: Makeeva
authors.affiliation: Russian Institute of People's Friendship, Moscow, Russia.
authors.forename: F Yu
authors.initials: FY
authors.lastname: Daurova
authors.affiliation: First Moscow State Medical University, Moscow, Russia.
authors.forename: S F
authors.initials: SF
authors.lastname: Byakova
authors.affiliation: Moscow State Medical and Dental University, Moscow, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Ippolitov
authors.affiliation: First Moscow State Medical University, Moscow, Russia.
authors.forename: M S
authors.initials: MS
authors.lastname: Gostev
authors.affiliation: First Moscow State Medical University, Moscow, Russia.
authors.forename: A O
authors.initials: AO
authors.lastname: Polikushina
authors.affiliation: First Moscow State Medical University, Moscow, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Shubin
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D004352:Drug Resistance, Microbial; D005122:Exudates and Transudates / Q000382:microbiology; D005260:Female; D005658:Fungi / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D010482:Periapical Abscess / Q000188:drug therapy / Q000382:microbiology*; D010514:Periodontal Pocket / Q000188:drug therapy / Q000382:microbiology*; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents