title: The Tohoku Medical Megabank Project: Design and Mission.
abstract: The Great East Japan Earthquake (GEJE) and resulting tsunami of March 11, 2011 gave rise to devastating damage on the Pacific coast of the Tohoku region. The Tohoku Medical Megabank Project (TMM), which is being conducted by Tohoku University Tohoku Medical Megabank Organization (ToMMo) and Iwate Medical University Iwate Tohoku Medical Megabank Organization (IMM), has been launched to realize creative reconstruction and to solve medical problems in the aftermath of this disaster. We started two prospective cohort studies in Miyagi and Iwate Prefectures: a population-based adult cohort study, the TMM Community-Based Cohort Study (TMM CommCohort Study), which will recruit 80 000 participants, and a birth and three-generation cohort study, the TMM Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study), which will recruit 70 000 participants, including fetuses and their parents, siblings, grandparents, and extended family members. The TMM CommCohort Study will recruit participants from 2013 to 2016 and follow them for at least 5 years. The TMM BirThree Cohort Study will recruit participants from 2013 to 2017 and follow them for at least 4 years. For children, the ToMMo Child Health Study, which adopted a cross-sectional design, was also started in November 2012 in Miyagi Prefecture. An integrated biobank will be constructed based on the two prospective cohort studies, and ToMMo and IMM will investigate the chronic medical impacts of the GEJE. The integrated biobank of TMM consists of health and clinical information, biospecimens, and genome and omics data. The biobank aims to establish a firm basis for personalized healthcare and medicine, mainly for diseases aggravated by the GEJE in the two prefectures. Biospecimens and related information in the biobank will be distributed to the research community. TMM itself will also undertake genomic and omics research. The aims of the genomic studies are: 1) to construct an integrated biobank; 2) to return genomic research results to the participants of the cohort studies, which will lead to the implementation of personalized healthcare and medicine in the affected areas in the near future; and 3) to contribute the development of personalized healthcare and medicine worldwide. Through the activities of TMM, we will clarify how to approach prolonged healthcare problems in areas damaged by large-scale disasters and how useful genomic information is for disease prevention.
authors.affiliation: Tohoku Medical Megabank Organization, Tohoku University.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kuriyama
authors.forename: Nobuo
authors.initials: N
authors.lastname: Yaegashi
authors.forename: Fuji
authors.initials: F
authors.lastname: Nagami
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Arai
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kawaguchi
authors.forename: Noriko
authors.initials: N
authors.lastname: Osumi
authors.forename: Masaki
authors.initials: M
authors.lastname: Sakaida
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Keiko
authors.initials: K
authors.lastname: Nakayama
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Hashizume
authors.forename: Gen
authors.initials: G
authors.lastname: Tamiya
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawame
authors.forename: Kichiya
authors.initials: K
authors.lastname: Suzuki
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hozawa
authors.forename: Naoki
authors.initials: N
authors.lastname: Nakaya
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kikuya
authors.forename: Hirohito
authors.initials: H
authors.lastname: Metoki
authors.forename: Ichiro
authors.initials: I
authors.lastname: Tsuji
authors.forename: Nobuo
authors.initials: N
authors.lastname: Fuse
authors.forename: Hideyasu
authors.initials: H
authors.lastname: Kiyomoto
authors.forename: Junichi
authors.initials: J
authors.lastname: Sugawara
authors.forename: Akito
authors.initials: A
authors.lastname: Tsuboi
authors.forename: Shinichi
authors.initials: S
authors.lastname: Egawa
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Ito
authors.forename: Koichi
authors.initials: K
authors.lastname: Chida
authors.forename: Tadashi
authors.initials: T
authors.lastname: Ishii
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Tomita
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Taki
authors.forename: Naoko
authors.initials: N
authors.lastname: Minegishi
authors.forename: Naoto
authors.initials: N
authors.lastname: Ishii
authors.forename: Jun
authors.initials: J
authors.lastname: Yasuda
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Igarashi
authors.forename: Ritsuko
authors.initials: R
authors.lastname: Shimizu
authors.forename: Masao
authors.initials: M
authors.lastname: Nagasaki
authors.forename: Seizo
authors.initials: S
authors.lastname: Koshiba
authors.forename: Kengo
authors.initials: K
authors.lastname: Kinoshita
authors.forename: Soichi
authors.initials: S
authors.lastname: Ogishima
authors.forename: Takako
authors.initials: T
authors.lastname: Takai-Igarashi
authors.forename: Teiji
authors.initials: T
authors.lastname: Tominaga
authors.forename: Osamu
authors.initials: O
authors.lastname: Tanabe
authors.forename: Noriaki
authors.initials: N
authors.lastname: Ohuchi
authors.forename: Toru
authors.initials: T
authors.lastname: Shimosegawa
authors.forename: Shigeo
authors.initials: S
authors.lastname: Kure
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tanaka
authors.forename: Sadayoshi
authors.initials: S
authors.lastname: Ito
authors.forename: Jiro
authors.initials: J
authors.lastname: Hitomi
authors.forename: Kozo
authors.initials: K
authors.lastname: Tanno
authors.forename: Motoyuki
authors.initials: M
authors.lastname: Nakamura
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Ogasawara
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Kiyomi
authors.initials: K
authors.lastname: Sakata
authors.forename: Mamoru
authors.initials: M
authors.lastname: Satoh
authors.forename: Atsushi
authors.initials: A
authors.lastname: Shimizu
authors.forename: Makoto
authors.initials: M
authors.lastname: Sasaki
authors.forename: Ryujin
authors.initials: R
authors.lastname: Endo
authors.forename: Kenji
authors.initials: K
authors.lastname: Sobue
authors.forename: The
authors.initials: T
authors.lastname: Tohoku Medical Megabank Project Study Group
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yamamoto
mesh_terms: D054597:Disaster Medicine / Q000458:organization & administration*; D004190:Disasters; D055866:Earthquakes; D006040:Goals; D006801:Humans; D007564:Japan; D011446:Prospective Studies; D057192:Tsunamis