title: A pilot study of intraluminal brachytherapy using125I seed strand for locally advanced pancreatic ductal adenocarcinoma with obstructive jaundice.
abstract: To investigate the safety and feasibility of intraluminal brachytherapy using125I seed strand for locally advanced pancreatic ductal adenocarcinoma with obstructive jaundice.
  
  
  
  From January 2010 to February 2015, 18 consecutive patients diagnosed with locally advanced, nonmetastatic, inoperable pancreatic ductal adenocarcinoma with obstructive jaundice were enrolled and underwent intraluminal brachytherapy using125I seed strand. Dose calculation was performed using a software. The procedure-related and radiation complications were assessed. Obstruction-free survival and overall survival were calculated using the Kaplan-Meier method.
  
  
  
  The technique successful rate of125I seed strand implantation was 100%. Successful bile drainage was achieved in all patients. The estimated mean accumulating dose (R = 5 mm, z = 0, 240 days) was 167.2 Gy, from 164.19 to 170.05 Gy. Two patients had adverse event of Grade 3, one of Grade 4. Stent dysfunction occurred in 1/18 (5.6%) patients. The mean and median obstruction-free survival time were 10.61 months (95% confidence interval [CI]: 7.04, 14.18) and 7.26 months (95% CI: 2.14, 12.38). The mean and median overall survival time were 11.91 months (95% CI: 7.39, 16.43) and 7.26 months (95% CI: 2.14, 12.38).
  
  
  
  Intraluminal brachytherapy using125I seed strand may be consider as a safe treatment option for the therapy of locally advanced pancreatic duct adenocarcinoma complicated by obstructive jaundice with acceptable complication rates.
authors.affiliation: Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, China; Shanghai Institution of Medical Imaging, Shanghai, China.
authors.forename: MinJie
authors.initials: M
authors.lastname: Yang
authors.affiliation: Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, China; Shanghai Institution of Medical Imaging, Shanghai, China.
authors.forename: ZhiPing
authors.initials: Z
authors.lastname: Yan
authors.affiliation: Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, China; Shanghai Institution of Medical Imaging, Shanghai, China.
authors.forename: JianJun
authors.initials: J
authors.lastname: Luo
authors.affiliation: Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, China; Shanghai Institution of Medical Imaging, Shanghai, China.
authors.forename: QingXin
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, China; Shanghai Institution of Medical Imaging, Shanghai, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, China; Shanghai Institution of Medical Imaging, Shanghai, China.
authors.forename: JinQing
authors.initials: J
authors.lastname: Ma
authors.affiliation: Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, China; Shanghai Institution of Medical Imaging, Shanghai, China.
authors.forename: ZiHan
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, China; Shanghai Institution of Medical Imaging, Shanghai, China.
authors.forename: TianZhu
authors.initials: T
authors.lastname: Yu
authors.affiliation: Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, China; Shanghai Institution of Medical Imaging, Shanghai, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, China; Shanghai Institution of Medical Imaging, Shanghai, China. Electronic address: 522623124@qq.com.
authors.forename: LingXiao
authors.initials: L
authors.lastname: Liu
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000532:radiotherapy*; D000328:Adult; D000368:Aged; D001918:Brachytherapy / Q000009:adverse effects / Q000379:methods*; D021441:Carcinoma, Pancreatic Ductal / Q000150:complications / Q000532:radiotherapy*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D041781:Jaundice, Obstructive / Q000209:etiology*; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D010166:Palliative Care / Q000379:methods; D010190:Pancreatic Neoplasms / Q000150:complications / Q000532:radiotherapy*; D010865:Pilot Projects; D011446:Prospective Studies; D011879:Radiotherapy Dosage; D015607:Stents
chemical_list: D007457:Iodine Radioisotopes
keywords: (125)I seed; Brachytherapy; Obstructive jaundice; Pancreatic ductal adenocarcinoma