title: Prediction of survival of diffuse large B-cell lymphoma patients via the expression of three inflammatory genes.
abstract: Currently, several gene-expression signatures that were used to predict survival of diffuse large B-cell lymphoma (DLBCL) patients, showed a restriction on the practical work for lack of convenient operation. In this study, we screened inflammatory genes whose expression correlated with survival of DLBCL and established a predictive model including IL6, IL1A and CSF3 through multivariate Cox regression based on the expression of these three genes. We validated the model at protein level in our clinical serum cohort composed of 101 patients of DLBCL and 50 healthy controls and 534 DLBCL patients at mRNA level from three independent Gene Expression Omnibus (GEO) data sets. We found our model to be independent of the International Prognostic Index (IPI), moreover, it can augment the predictive power of IPI. In summary, our three-gene model is sufficient to predict survival of DLBCL patients via measuring the concentration of three inflammatory cytokines in peripheral blood.
authors.affiliation: School of Medicine, 94 Weijin Road, Tianjin, 300071, China.|Collaborative Innovation Center for Biotherapy, Nankai University, 94 Weijin Road, Tianjin, 300071, China.
authors.forename: Shuangtao
authors.initials: S
authors.lastname: Zhao
authors.affiliation: School of Medicine, 94 Weijin Road, Tianjin, 300071, China.|Prenatal Diagnosis Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Bai
authors.affiliation: School of Medicine, 94 Weijin Road, Tianjin, 300071, China.|Collaborative Innovation Center for Biotherapy, Nankai University, 94 Weijin Road, Tianjin, 300071, China.|Tianjin Key Laboratory of Tumor Microenvironment and Neurovascular Regulation, Tianjin, 300071, China.
authors.forename: Jianlin
authors.initials: J
authors.lastname: Cui
authors.affiliation: School of Medicine, 94 Weijin Road, Tianjin, 300071, China.|Collaborative Innovation Center for Biotherapy, Nankai University, 94 Weijin Road, Tianjin, 300071, China.|Tianjin Key Laboratory of Tumor Microenvironment and Neurovascular Regulation, Tianjin, 300071, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Xiang
authors.affiliation: School of Medicine, 94 Weijin Road, Tianjin, 300071, China.|Collaborative Innovation Center for Biotherapy, Nankai University, 94 Weijin Road, Tianjin, 300071, China.|Tianjin Key Laboratory of Tumor Microenvironment and Neurovascular Regulation, Tianjin, 300071, China.
authors.forename: Na
authors.initials: N
authors.lastname: Li
mesh_terms: D015703:Antigens, CD / Q000235:genetics / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000235:genetics / Q000378:metabolism; D014408:Biomarkers, Tumor; D045744:Cell Line, Tumor; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D030541:Databases, Genetic; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D018836:Inflammation Mediators; D053208:Kaplan-Meier Estimate; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics* / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D008297:Male; D011379:Prognosis; D012372:ROC Curve; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism; D015203:Reproducibility of Results; D000098902:CD163 Antigen
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D014408:Biomarkers, Tumor; D000098902:CD163 Antigen; D016207:Cytokines; D018836:Inflammation Mediators; D011956:Receptors, Cell Surface
keywords: CSF3; IL1A; IL6; diffuse large B-cell lymphoma; tumor microenvironment; tumor-associated macrophages