title: Meta-Analysis for the Association between Polymorphisms in Interleukin-17A and Risk of Coronary Artery Disease.
abstract: Coronary artery disease (CAD) is a disease which has become a leading cause of death worldwide. The polymorphisms in Interleukin-17 (IL-17A), including rs2275913, rs3819024, rs3819025, rs3748067, rs8193037, rs4711998, and rs8193036, have been found to be probably associated with the risk of CAD. However, the results were inconsistent and inconclusive. The present study performed a meta-analysis to get a more precise and comprehensive estimation of the association between the IL-17A polymorphisms and CAD risk. The Pubmed, Embase, Cochrane Central Register of Controlled Trials, Chinese National Knowledge Infrastructure, and Chinese Biomedical Literature Databases were searched for related studies. A total of six studies, including 3542 cases and 3212 controls, were identified for the meta-analysis. The main findings of the present meta-analysis show that the TT genotype of IL-17A rs3748067 is associated with a significant lower risk of CAD in the homozygous model odds ratio (OR) (OR = 0.37) in Asians. No significant association was found for rs2275913, rs3819024, rs3819025, rs8193037, rs4711998, and rs8193036 with CAD susceptibility in the overall analysis. However, subgroup analysis indicated a significant decreased risk of CAD for the GG genotype and G allele of rs2275913 in a small sample size group, and a higher risk of CAD for the GG genotype and G allele of rs8193037 in a heterozygous model (OR = 1.56), dominant model (OR = 1.54), and allelic model (OR = 1.47) in Asians. In conclusion, the current meta-analysis suggests a significant relationship between rs3748067, rs8193037, and CAD in Asians, while for rs2275913, rs3819024, rs3819025, rs4711998, rs8193036, no such relations were found. Thus, IL-17A rs3748067 and rs8193037 might be recommended as a predictor for susceptibility of CAD for Asians. However, the results of this meta-analysis are hypothesis-generating results which should be interpreted with caution because of the heterogeneity and publication bias among study designs.
authors.affiliation: Department of Anatomy, Histology and Embryology, Institute of Neuroscience, Changsha Medical University, Changsha 410219, China. mhbao78@163.com.
authors.forename: Mei-Hua
authors.initials: MH
authors.lastname: Bao
authors.affiliation: Department of Anatomy, Histology and Embryology, Institute of Neuroscience, Changsha Medical University, Changsha 410219, China. luohuaiqing@163.com.
authors.forename: Huai-Qing
authors.initials: HQ
authors.lastname: Luo
authors.affiliation: Department of Anatomy, Histology and Embryology, Institute of Neuroscience, Changsha Medical University, Changsha 410219, China. Xiang.ju@foxmail.com.
authors.forename: Ju
authors.initials: J
authors.lastname: Xiang
authors.affiliation: Department of Anatomy, Histology and Embryology, Institute of Neuroscience, Changsha Medical University, Changsha 410219, China. tlcool318@163.com.
authors.forename: Liang
authors.initials: L
authors.lastname: Tang
authors.affiliation: Department of Anatomy, Histology and Embryology, Institute of Neuroscience, Changsha Medical University, Changsha 410219, China. ddongliping@163.com.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Dong
authors.affiliation: Department of Anatomy, Histology and Embryology, Institute of Neuroscience, Changsha Medical University, Changsha 410219, China. liguangyi1977@163.com.
authors.forename: Guang-Yi
authors.initials: GY
authors.lastname: Li
authors.affiliation: Department of Anatomy, Histology and Embryology, Institute of Neuroscience, Changsha Medical University, Changsha 410219, China. zengjie84117@163.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Zeng
authors.affiliation: Department of Anatomy, Histology and Embryology, Institute of Neuroscience, Changsha Medical University, Changsha 410219, China. ljming0901@sina.com.|Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China. ljming0901@sina.com.
authors.forename: Jian-Ming
authors.initials: JM
authors.lastname: Li
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020381:Interleukin-17 / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012306:Risk
chemical_list: C508717:IL17A protein, human; D020381:Interleukin-17
keywords: IL-17A; coronary artery disease; meta-analysis; polymorphism; rs2275913; rs3748067; rs8193037