title: Prenatal PBDE and PCB Exposures and Reading, Cognition, and Externalizing Behavior in Children.
abstract: Prenatal polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) exposures may influence children's neurodevelopment.
  
  
  
  We examined the association of prenatal PBDE and PCB exposures with children's reading skills at ages 5 and 8 years, Full-Scale Intelligence Quotient (FSIQ), and externalizing behavior problems at age 8 years.
  
  
  
  From 239 mother-child pairs recruited (2003-2006) in Cincinnati, Ohio, we measured maternal serum PBDE and PCB concentrations, assessed child's reading skills using the Woodcock-Johnson Tests of Achievement III (WJ-III) at age 5 years and the Wide Range Achievement Test-4 (WRAT-4) at age 8 years, tested FSIQ using the Wechsler Intelligence Scale for Children-IV (WISC-IV), and externalizing behavior problems using the Behavioral Assessment System for Children-2 (BASC-2) at age 8 years. We used multiple linear regression to examine the association of prenatal PBDE and PCB concentrations and reading, FSIQ, and externalizing behavior problems after adjusting for covariates.
  
  
  
  An increase of Sum4PBDEs (BDE-47, BDE-99, BDE-100, and BDE-153) by 10 times was not significantly associated with reading scores at age 5 years at thep= 0.05 level but was inversely associated with Reading Composite scores (β: -6.2, 95% CI: -11.7, -0.6) and FSIQ (β: -5.3, 95% CI: -10.6, -0.02) at age 8 years; it was positively associated with the score for externalizing behavior problems (β: 3.5, 95% CI: -0.1, 7.2) at age 8 years. Prenatal Sum4PCBs (PCB-118, -153, -138-158, and -180) was not significantly associated with a child's reading skills, FSIQ, and externalizing behavior problems.
  
  
  
  Prenatal PBDE concentration was inversely associated with reading skills and FSIQ and positively associated with externalizing behavior problems at age 8 years. No significant associations were found in prenatal PCB concentration.
authors.affiliation: Department of Environmental Health, School of Public Health, Shanxi Medical University, Taiyuan, Shanxi Province, China.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Zhang
authors.forename: Kimberly
authors.initials: K
authors.lastname: Yolton
authors.forename: Glenys M
authors.initials: GM
authors.lastname: Webster
authors.forename: Andreas
authors.initials: A
authors.lastname: Sjödin
authors.forename: Antonia M
authors.initials: AM
authors.lastname: Calafat
authors.forename: Kim N
authors.initials: KN
authors.lastname: Dietrich
authors.forename: Yingying
authors.initials: Y
authors.lastname: Xu
authors.forename: Changchun
authors.initials: C
authors.lastname: Xie
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Braun
authors.forename: Bruce P
authors.initials: BP
authors.lastname: Lanphear
authors.forename: Aimin
authors.initials: A
authors.lastname: Chen
mesh_terms: D002648:Child; D002652:Child Behavior / Q000187:drug effects*; D002675:Child, Preschool; D003071:Cognition / Q000187:drug effects*; D005260:Female; D055768:Halogenated Diphenyl Ethers / Q000378:metabolism* / Q000633:toxicity; D006801:Humans; D008297:Male; D018811:Maternal Exposure / Q000706:statistics & numerical data*; D009820:Ohio; D011078:Polychlorinated Biphenyls / Q000378:metabolism* / Q000633:toxicity; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology; D011932:Reading
chemical_list: D055768:Halogenated Diphenyl Ethers; D011078:Polychlorinated Biphenyls