title: Biomimetic Immuno-Magnetosomes for High-Performance Enrichment of Circulating Tumor Cells.
abstract: A novel biomimetic immuno-magnetosome (IMS) is developed by coating a leukocyte membrane (decorated with anti-epithelial cell-adhesion molecule antibody) on a magnetic nanocluster. In addition to the good stability and magnetic controllability, the IMS also exhibits satisfactory binding avidity to circulating tumor cells but stealth property to leukocytes. As a result, rare tumor cells can be effectively enriched with undetectable leukocyte background.
authors.affiliation: School of Life Science, Beijing Institute of Technology, Beijing, 100081, P. R. China.
authors.forename: Ke
authors.initials: K
authors.lastname: Xiong
authors.affiliation: State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.affiliation: School of Life Science, Beijing Institute of Technology, Beijing, 100081, P. R. China.
authors.forename: Yongjie
authors.initials: Y
authors.lastname: Jin
authors.affiliation: School of Life Science, Beijing Institute of Technology, Beijing, 100081, P. R. China.
authors.forename: Shumin
authors.initials: S
authors.lastname: Wang
authors.affiliation: School of Life Science, Beijing Institute of Technology, Beijing, 100081, P. R. China.
authors.forename: Dongxu
authors.initials: D
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Xiaoyong
authors.initials: X
authors.lastname: Gao
authors.affiliation: State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Chenmeng
authors.initials: C
authors.lastname: Qiao
authors.affiliation: State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Hua
authors.initials: H
authors.lastname: Yue
authors.affiliation: State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Guanghui
authors.initials: G
authors.lastname: Ma
authors.affiliation: School of Life Science, Beijing Institute of Technology, Beijing, 100081, P. R. China. hyanxie@bit.edu.cn.
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Xie
mesh_terms: D040761:Biomimetic Materials; D015815:Cell Adhesion Molecules / Q000276:immunology; D002452:Cell Count; D002469:Cell Separation / Q000295:instrumentation* / Q000379:methods*; D006801:Humans; D007962:Leukocytes / Q000166:cytology; D055944:Magnetosomes / Q000276:immunology*; D009360:Neoplastic Cells, Circulating
chemical_list: D015815:Cell Adhesion Molecules
keywords: biomimetics; capture efficiency; circulating tumor cells; leukocyte backgrounds; magnetic particles