title: Effects of arteannuin B, arteannuic acid and scopoletin on pharmacokinetics of artemisinin in mice.
abstract: OBJECTIVE
  To explore the effects of arteannuin B, arteannuic acid and scopoletin on the pharmacokinetics of artemisinin in mice.
  
  
  METHODS
  Artemisinin and a combination of artemisinin, arteannuin B, arteannuic acid and scopoletin were administered together to mice via oral administration. Blood samples were collected at different time intervals and pretreated by liquid-liquid extraction. The contents of four compounds in mouse plasma were determined by a validated HPLC-MS/MS method.
  
  
  RESULTS
  Compared to single artemisinin group, the Cmax values from the combination group rose from 947 ng/mL to 1254 ng/mL. AUC(0-t) (2371 h ng/mL) was significantly higher than that from single artemisinin group (747 h ng/mL). The peak time lag and the CL values reduced at a proportion of 66%.
  
  
  CONCLUSIONS
  Arteannuin B, arteannuic acid and scopoletin can markedly affect the pharmacokinetics of artemisinin.
authors.affiliation: School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Zhang
authors.affiliation: School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China.
authors.forename: Mu-Xin
authors.initials: MX
authors.lastname: Gong
authors.affiliation: School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Qiu
authors.affiliation: School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China. Electronic address: wangmyjun@163.com.
authors.forename: Man-Yuan
authors.initials: MY
authors.lastname: Wang
keywords: Arteannuic acid; Arteannuin B; Artemisinin; Pharmacokinetics; Scopoletin