title: Cardiovascular effects of dexmedetomidine, with or without MK-467, following intravenous administration in cats.
abstract: OBJECTIVE
  To characterize the cardiovascular effects of dexmedetomidine, with or without MK-467, following intravenous (IV) administration in cats.
  
  
  METHODS
  Prospective Latin square experimental study.
  
  
  METHODS
  Six healthy adult purpose-bred cats.
  
  
  METHODS
  Cats were anesthetized with desflurane in oxygen for instrumentation with a carotid artery catheter and a thermodilution catheter in the pulmonary artery. One hour after discontinuation of desflurane, cats were administered dexmedetomidine (25 μg kg-1), MK-467 (600 μg kg-1), or dexmedetomidine (25 μg kg-1) and MK-467 (600 μg kg-1). All treatments were administered IV as a bolus. Cardiovascular variables were measured prior to drug administration and for 8 hours thereafter. Only data from the dexmedetomidine and dexmedetomidine-MK-467 treatments were analyzed.
  
  
  RESULTS
  Dexmedetomidine produced significant decreases in heart rate, cardiac index and right ventricular stroke work index, and significant increases in arterial blood pressure, central venous pressure, pulmonary artery pressure and systemic vascular resistance index. Dexmedetomidine combined with MK-467 resulted in significant but transient decrease in blood pressure and right ventricular stroke work index.
  
  
  CONCLUSIONS
  Following IV co-administration, MK-467 effectively attenuated dexmedetomidine-induced cardiovascular effects in cats. The drug combination resulted in transient reduction in arterial blood pressure, without causing hypotension.
authors.affiliation: Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, USA. Electronic address: bhpypendop@ucdavis.edu.
authors.forename: Bruno H
authors.initials: BH
authors.lastname: Pypendop
authors.affiliation: Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
authors.forename: Juhana
authors.initials: J
authors.lastname: Honkavaara
authors.affiliation: Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, USA.
authors.forename: Jan E
authors.initials: JE
authors.lastname: Ilkiw
mesh_terms: D058647:Adrenergic alpha-2 Receptor Agonists / Q000009:adverse effects / Q000494:pharmacology*; D058669:Adrenergic alpha-2 Receptor Antagonists / Q000494:pharmacology*; D000771:Anesthesia, Intravenous / Q000662:veterinary; D018685:Anesthetics, Inhalation; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002319:Cardiovascular System / Q000187:drug effects; D002415:Cats; D000077335:Desflurane; D020927:Dexmedetomidine / Q000009:adverse effects / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D007530:Isoflurane / Q000031:analogs & derivatives; D011446:Prospective Studies; D011807:Quinolizines / Q000494:pharmacology*; D014661:Vasoconstriction
chemical_list: D058647:Adrenergic alpha-2 Receptor Agonists; D058669:Adrenergic alpha-2 Receptor Antagonists; D018685:Anesthetics, Inhalation; D011807:Quinolizines; C055732:vatinoxan; D020927:Dexmedetomidine; D000077335:Desflurane; D007530:Isoflurane
keywords: antagonist; cardiovascular; cat; dexmedetomidine