title: Accumulation of neurotoxic organochlorines and trace elements in brain of female European eel (Anguilla anguilla).
abstract: Xenobiotics such as organochlorine compounds (OCs) and metals have been suggested to play a significant role in the collapse of European eel stocks in the last decades. Several of these pollutants could affect functioning of the nervous system. Still, no information is so far available on levels of potentially neurotoxic pollutants in eel brain. In present study, carried out on female eels caught in Belgian rivers and canals, we analyzed brain levels of potentially-neurotoxic trace elements (Ag, Al, As, Cd, Co, Cr, Cu, Fe, Hg, MeHg, Mn, Ni, Pb, Sn, Sb, Zn) and OCs (Polychlorinated biphenyls, PCBs; Hexachlorocyclohexanes, HCHs; Dichlorodiphenyltrichloroethane and its metabolites, DDTs). Data were compared to levels in liver and muscle tissues. Eel brain contained very high amounts of OCs, superior to those found in the two other tissues. Interestingly, the relative abundance of PCB congeners markedly differed between tissues. In brain, a predominance of low chlorinated PCBs was noted, whereas highly chlorinated congeners prevailed in muscle and liver. HCHs were particularly abundant in brain, which contains the highest amounts of β-HCH and ϒ-HCH. p,p'-DDTs concentration was similar between brain and muscle (i.e., about twice that of liver). A higher proportion of p,p'-DDT was noticed in brain. Except for Cr and inorganic Hg, all potentially neurotoxic metals accumulated in brain to levels equal to or lower than hepatic levels. Altogether, results indicate that eel brain is an important target for organic and, to a lesser extent, for inorganic neurotoxic pollutants.
authors.affiliation: Université catholique de Louvain, Institut des Sciences de la Vie, Croix du Sud, 2/L7.05.08, B-1348 Louvain-la-Neuve, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: Bonnineau
authors.affiliation: Université catholique de Louvain, Institut des Sciences de la Vie, Croix du Sud, 2/L7.05.08, B-1348 Louvain-la-Neuve, Belgium.
authors.forename: D
authors.initials: D
authors.lastname: Scaion
authors.affiliation: Université catholique de Louvain, Institut des Sciences de la Vie, Croix du Sud, 2/L7.05.08, B-1348 Louvain-la-Neuve, Belgium.
authors.forename: B
authors.initials: B
authors.lastname: Lemaire
authors.affiliation: Research Institute for Nature and Forest (INBO), Duboislaan 14, 1560 Hoeilaart, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: Belpaire
authors.affiliation: Laboratoire d'Ecologie animale et d'Ecotoxicologie, Institut de Zoologie, Université de Liège, Quai Van Beneden 22, 4020 Liège, Belgium.
authors.forename: J-P
authors.initials: JP
authors.lastname: Thomé
authors.affiliation: Laboratoire d'Ecologie animale et d'Ecotoxicologie, Institut de Zoologie, Université de Liège, Quai Van Beneden 22, 4020 Liège, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Thonon
authors.affiliation: Analytical and Environmental Chemistry, Department of Chemistry, Faculty of Science, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Elsene, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Leermaker
authors.affiliation: Analytical and Environmental Chemistry, Department of Chemistry, Faculty of Science, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Elsene, Belgium.
authors.forename: Y
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Université catholique de Louvain, Institut des Sciences de la Vie, Croix du Sud, 2/L7.05.08, B-1348 Louvain-la-Neuve, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: Debier
authors.affiliation: Unité de Recherche en Biologie Environnementale et Evolutive (URBE), Université de Namur, Rue de Bruxelles 61, B-5000, Namur, Belgium.
authors.forename: F
authors.initials: F
authors.lastname: Silvestre
authors.affiliation: Unité de Recherche en Biologie Environnementale et Evolutive (URBE), Université de Namur, Rue de Bruxelles 61, B-5000, Namur, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Kestemont
authors.affiliation: Université catholique de Louvain, Institut des Sciences de la Vie, Croix du Sud, 2/L7.05.08, B-1348 Louvain-la-Neuve, Belgium. Electronic address: jf.rees@uclouvain.be.
authors.forename: J-F
authors.initials: JF
authors.lastname: Rees
mesh_terms: D000811:Anguilla / Q000378:metabolism*; D000818:Animals; D001530:Belgium; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D004784:Environmental Monitoring; D005260:Female; D006843:Hydrocarbons, Chlorinated / Q000493:pharmacokinetics* / Q000633:toxicity; D045483:Rivers / Q000737:chemistry; D014018:Tissue Distribution; D014131:Trace Elements / Q000493:pharmacokinetics* / Q000633:toxicity; D014874:Water Pollutants, Chemical / Q000493:pharmacokinetics* / Q000633:toxicity
chemical_list: D006843:Hydrocarbons, Chlorinated; D014131:Trace Elements; D014874:Water Pollutants, Chemical
keywords: Brain; Eel; Mercury; Metals; Organochlorine pesticides; PCBs; Toxicology