title: Effects of Apium graveolens Extract on the Oxidative Stress in the Liver of Adjuvant-Induced Arthritic Rats.
abstract: Apium graveolens Linn. (Apiaceae) is an indigenous plant of the North and South Americas, Southern Europe, and Asia and has been widely used as a food or a traditional medicine for treatment of inflammation and arthritis. The purpose of this study was to investigate the antioxidant effects of a methanolic extract of A. graveolens (AGE) against liver oxidative stress in an adjuvant-induced arthritic rat model. The AGE (250, 500, and 1,000 mg/kg) was given orally for 24 consecutive days after induction by injecting complete Freund's adjuvant. Liver and spleen weights were recorded. The superoxide anion level, total peroxide (TP), glutathione peroxidase (GPx) activity, superoxide dismutase (SOD) activity, total antioxidant status, and oxidative stress index (OSI) were also measured. AGE treatment significantly decreased the levels of the superoxide anion, TP, and OSI whereas the GPx and SOD activities significantly increased in the liver of the arthritic rats. These results indicated that AGE showed an ameliorative effect against liver oxidative stress in adjuvant-induced arthritic rats by reducing the generation of liver free radicals and increasing the liver antioxidant enzyme activity.
authors.affiliation: Department of Pharmacology, Faculty of Science, Prince of Songkla University, Songkhla 90112, Thailand.
authors.forename: Wanida
authors.initials: W
authors.lastname: Sukketsiri
authors.affiliation: Department of Physiology, Faculty of Science, Prince of Songkla University, Songkhla 90112, Thailand.
authors.forename: Pennapa
authors.initials: P
authors.lastname: Chonpathompikunlert
authors.affiliation: Department of Anatomy, Faculty of Science, Prince of Songkla University, Songkhla 90112, Thailand.
authors.forename: Supita
authors.initials: S
authors.lastname: Tanasawet
authors.affiliation: Department of Pharmacology, Faculty of Science, Prince of Songkla University, Songkhla 90112, Thailand.
authors.forename: Nutjanat
authors.initials: N
authors.lastname: Choosri
authors.affiliation: Department of Anatomy, Faculty of Science, Prince of Songkla University, Songkhla 90112, Thailand.
authors.forename: Tulaporn
authors.initials: T
authors.lastname: Wongtawatchai
keywords: Chinese celery; adjuvant-induced arthritis; liver oxidative stress; reactive oxygen species; rheumatoid arthritis