title: Effect of non-alcoholic fatty liver disease on left ventricular diastolic function and geometry in the Korean general population.
abstract: OBJECTIVE
  Previous studies showed that non-alcoholic fatty liver disease (NALFD) could be related to subclinical left ventricular (LV) diastolic dysfunction and remodeling. However, this association is still equivocal in the general population. Thus, this study was carried out to examine whether NAFLD is associated with the risk for LV diastolic dysfunction and remodeling.
  
  
  METHODS
  A cross-sectional study was carried out for 20 821 Korean men and women who received a health checkup including echocardiography from 2011 to 2012. The study population was divided into three groups of normal, mild and moderate-to-severe NAFLD detected by ultrasonography. Using multivariable logistic regression analysis, the odd ratios of abnormal LV relaxation and remodeling were analyzed according to the degree of NAFLD. Additionally, adjusted mean values of LV diastolic functional and structural parameters were evaluated in the three groups.
  
  
  RESULTS
  Compared with the normal group, the mild and moderate-to-severe NAFLD groups had higher odd ratios for abnormal LV relaxation (mild group 1.29, 95% confidence interval 1.15-1.46; moderate-to-severe group 1.95, 95% confidence interval 1.61-2.35) and increased relative wall thickness (>0.42; mild group 1.26, 95% confidence interval 1.05-1.52; moderate-to-severe group 1.46, 95% confidence interval 1.08-1.95). Analyzing adjusted mean values of LV parameters also showed the significant association between the degree of NAFLD and impaired LV diastolic function and concentric LV remodeling.
  
  
  CONCLUSIONS
  The risk for LV diastolic dysfunction and remodeling proportionally increased according to the degree of NAFLD. NAFLD is significantly associated with LV functional and structural alteration.
authors.affiliation: Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University, Goyang, Korea.|School of Medicine, Departments of Medicine, Graduate School, Kyung Hee University, Goyang, Korea.
authors.forename: Ju Young
authors.initials: JY
authors.lastname: Jung
authors.affiliation: Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University, Goyang, Korea.
authors.forename: Sung Keun
authors.initials: SK
authors.lastname: Park
authors.affiliation: Department of Preventive Medicine, School of Medicine, Kyung Hee University, Goyang, Korea.
authors.forename: Jae-Hong
authors.initials: JH
authors.lastname: Ryoo
authors.affiliation: Cancer Registration and Statistic Branch, National Cancer Control Institute, National Cancer Center, Goyang, Korea.
authors.forename: Chang-Mo
authors.initials: CM
authors.lastname: Oh
authors.affiliation: Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University, Goyang, Korea.
authors.forename: Jeong Gyu
authors.initials: JG
authors.lastname: Kang
authors.affiliation: Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, Ontario, Canada.|Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.|Department of Psychiatry, School of Medicine, Sungkyunkwan University, Seoul, Korea.
authors.forename: Jae-Hon
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Preventive Medicine, School of Medicine, Kyung Hee University, Goyang, Korea.
authors.forename: Joong-Myung
authors.initials: JM
authors.lastname: Choi
keywords: fatty liver; heart failure; left ventricular diastolic dysfunction; left ventricular remodeling