title: COGAN'S SYNDROME.
abstract: OBJECTIVE
  The objective of our study was to review the current knowledge on Cogan's syndrome, including etiology, diagnosis and treatment. Systematic review methodology: Relevant publications on Cogan's syndrome from 1945 to 2014 were studied.
  
  
  CONCLUSIONS
  Cogan's syndrome is a rare autoimmune vasculitis, with unknown pathogenesis. Infection was thought to have played a role in the pathogenesis of the disease, but now the autoimmunity hypothesis is considered more likely to be true. Cogan's syndrome is characterized by ocular and audiovestibular symptoms similar to those of Meniere's syndrome. Approximately 70% of the patients have systemic disease, of which vasculitis is considered the pathological mechanism. Corticosteroids are the first line of treatment; multiple immunosuppressive drugs were also used with varying degrees of success. The novelty in the treatment of the disease is tumor necrosis factor (TNF)-alpha-blockers, but more studies are necessary to establish their efficacy.
authors.forename: Daniela Adriana
authors.initials: DA
authors.lastname: Iliescu
authors.forename: Cristina Mihaela
authors.initials: CM
authors.lastname: Timaru
authors.forename: Mehdi
authors.initials: M
authors.lastname: Batras
authors.forename: Algerino
authors.initials: A
authors.lastname: De Simone
authors.forename: Cornel
authors.initials: C
authors.lastname: Stefan
mesh_terms: D055952:Cogan Syndrome / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology*; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007759:Labyrinth Diseases / Q000276:immunology; D035583:Rare Diseases; D012383:Romania / Q000453:epidemiology; D016896:Treatment Outcome; D014657:Vasculitis / Q000276:immunology
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents