title: Could omega-3 fatty acids a therapeutic treatment of the immune-metabolic consequence of intermittent hypoxia in obstructive sleep apnea?
abstract: Obesity and Obstructive sleep Apnea (OSA) seems to bi-directional; obesity itself increases the risk of OSA, but on the other hand, OSA may also predispose the individuals to weight gain, both obesity and OSA share a common immune-metabolic link state which have a synergistic effect on the activation of inflammation, insulin resistance and dyslipidemia, and cardiovascular disease. The Immune-metabolic role of omega-3 fatty acids Docosahexaenoic acid (DHA) and Eicosapentaenoic acid (EPA), which capable of modulating both metabolic and immune process, which may decrease pro-inflammatory cytokines, insulin resistance, and dyslipidemia. To date, no study in humans suffering from OSA and omega-3 fatty acids has been performed. Hence, the objective of this review aimed to discussing the link between immune-metabolic consequences related to intermittent hypoxia and does Omega-3 fatty acids a therapeutic treatment for co-morbidity associated with obstructive sleep apnea.
authors.affiliation: Department of Nutrition and Food Technology, Faculty of Agriculture, The University of Jordan, 11942 Amman, Jordan. Electronic address: mralfandi@yahoo.com.
authors.forename: Mohammed R
authors.initials: MR
authors.lastname: Alzoubi
authors.affiliation: Department of Nutrition and Food Technology, Faculty of Agriculture, The University of Jordan, 11942 Amman, Jordan. Electronic address: h.aldomi@ju.edu.jo.
authors.forename: Hayder
authors.initials: H
authors.lastname: Aldomi Al-Domi
mesh_terms: D015897:Comorbidity; D004734:Energy Metabolism / Q000187:drug effects; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use*; D006801:Humans; D000860:Hypoxia / Q000178:diet therapy* / Q000209:etiology* / Q000276:immunology / Q000378:metabolism; D007107:Immune System / Q000187:drug effects / Q000503:physiopathology; D007249:Inflammation / Q000150:complications / Q000453:epidemiology / Q000276:immunology / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology; D024821:Metabolic Syndrome / Q000150:complications / Q000453:epidemiology; D009765:Obesity / Q000150:complications / Q000453:epidemiology / Q000276:immunology / Q000378:metabolism; D020181:Sleep Apnea, Obstructive / Q000150:complications* / Q000178:diet therapy* / Q000276:immunology / Q000378:metabolism
chemical_list: D015525:Fatty Acids, Omega-3
keywords: Inflammation; Insulin resistance; Intermittent hypoxia; Obesity; Obstructive sleep apnea; Omega 3 fatty acids