title: Aberrant Lipid Metabolism Promotes Prostate Cancer: Role in Cell Survival under Hypoxia and Extracellular Vesicles Biogenesis.
abstract: Prostate cancer (PCa) is the leading malignancy among men in United States. Recent studies have focused on the identification of novel metabolic characteristics of PCa, aimed at devising better preventive and therapeutic approaches. PCa cells have revealed unique metabolic features such as higher expression of several enzymes associated with de novo lipogenesis, fatty acid up-take and β-oxidation. This aberrant lipid metabolism has been reported to be important for PCa growth, hormone-refractory progression and treatment resistance. Furthermore, PCa cells effectively use lipid metabolism under adverse environmental conditions for their survival advantage. Specifically, hypoxic cancer cells accumulate higher amount of lipids through a combination of metabolic alterations including high glutamine and fatty acid uptake, as well as decreased fatty acid oxidation. These stored lipids serve to protect cancer cells from oxidative and endoplasmic reticulum stress, and play important roles in fueling cancer cell proliferation following re-oxygenation. Lastly, cellular lipids have also been implicated in extracellular vesicle biogenesis, which play a vital role in intercellular communication. Overall, the new understanding of lipid metabolism in recent years has offered several novel targets to better target and manage clinical PCa.
authors.affiliation: Department of Cancer Biology, Wake Forest Baptist Medical Center, Winston-Salem, NC 27157, USA. gdeep@wakehealth.edu.
authors.forename: Gagan
authors.initials: G
authors.lastname: Deep
authors.affiliation: Division of Medical Oncology, Genitourinary Cancer Program, University of Colorado School of Medicine, Aurora, CO 80045, USA. Isabel.Schlaepfer@ucdenver.edu.
authors.forename: Isabel R
authors.initials: IR
authors.lastname: Schlaepfer
mesh_terms: D000818:Animals; D015687:Cell Hypoxia; D002470:Cell Survival; D059865:Endoplasmic Reticulum Stress; D006801:Humans; D050356:Lipid Metabolism; D008297:Male; D018384:Oxidative Stress; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology
keywords: carnitine palmitoyltransferase (CPT1); extracellular vesicles; fatty acid oxidation; hypoxia; lipogenesis; prostate cancer; re-oxygenation