title: Electrophysiological mechanisms of biased response to smoking-related cues in young smokers.
abstract: Cigarette smoking during young adult may result in serious health issues in later life. Hence, it is extremely necessary to study the smoking neurophysiological mechanisms in this critical transitional period. However, few studies revealed the electrophysiological mechanisms of cognitive processing biases in young adult smokers. In present study, nineteen young smokers with 12h abstinent and 19 matched nonsmokers were recruited. By employing event-related potentials (ERP) measurements during a smoking cue induced craving task, electrophysiological brain responses were compared between the young adult smokers and nonsmokers. The Slow Positive Wave (SPW) amplitude of smoking-related cues was enhanced in young adult smokers compared with nonsmokers. In addition, increased P300/SPW component of smoking-related cues relative to neutral cues were found in young adult smokers. Meanwhile, a positive correlation between Cigarette Per Day (CPD) and the amplitude of ERPs wave (P300/SPW) at anterior (Fz), central (Cz) were observed in young adult smokers. Our findings provided direct electrophysiological evidence for the cognitive processing bias of smoking cue and may shed new insights into the smoking behavior in young adult smokers.
authors.affiliation: School of Life Science and Technology, Xidian University, Xi'an, People's Republic of China; Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, People's Republic of China.
authors.forename: Jiadong
authors.initials: J
authors.lastname: Cheng
authors.affiliation: School of Life Science and Technology, Xidian University, Xi'an, People's Republic of China; Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, People's Republic of China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Guan
authors.affiliation: School of Life Science and Technology, Xidian University, Xi'an, People's Republic of China; Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, People's Republic of China.
authors.forename: Yajuan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: School of Life Science and Technology, Xidian University, Xi'an, People's Republic of China; Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, People's Republic of China.
authors.forename: Yanzhi
authors.initials: Y
authors.lastname: Bi
authors.affiliation: Information Processing Laboratory, School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, People's Republic of China.
authors.forename: Limei
authors.initials: L
authors.lastname: Bu
authors.affiliation: School of Life Science and Technology, Xidian University, Xi'an, People's Republic of China; Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, People's Republic of China.
authors.forename: Yangding
authors.initials: Y
authors.lastname: Li
authors.affiliation: School of Life Science and Technology, Xidian University, Xi'an, People's Republic of China; Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, People's Republic of China.
authors.forename: Sha
authors.initials: S
authors.lastname: Shi
authors.affiliation: School of Life Science and Technology, Xidian University, Xi'an, People's Republic of China; Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, People's Republic of China.
authors.forename: Peng
authors.initials: P
authors.lastname: Liu
authors.affiliation: Information Processing Laboratory, School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, People's Republic of China.
authors.forename: Xiaoqi
authors.initials: X
authors.lastname: Lu
authors.affiliation: Information Processing Laboratory, School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, People's Republic of China. Electronic address: fmydh@imust.edu.cn.
authors.forename: Dahua
authors.initials: D
authors.lastname: Yu
authors.affiliation: School of Life Science and Technology, Xidian University, Xi'an, People's Republic of China; Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, People's Republic of China; Information Processing Laboratory, School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, People's Republic of China. Electronic address: kyuan@xidian.edu.cn.
authors.forename: Kai
authors.initials: K
authors.lastname: Yuan
mesh_terms: D000328:Adult; D002540:Cerebral Cortex / Q000503:physiopathology*; D003071:Cognition / Q000502:physiology*; D066249:Craving / Q000502:physiology*; D003463:Cues; D004569:Electroencephalography; D018913:Event-Related Potentials, P300; D006801:Humans; D008297:Male; D012907:Smoking / Q000503:physiopathology* / Q000523:psychology*; D055815:Young Adult
keywords: Cognitive processing bias; Event-related potentials (ERP); P300; Slow Positive Wave (SPW); Young adult smokers