title: Characterization of lipid-rich plaques using spectroscopic optical coherence tomography.
abstract: Intravascular optical coherence tomography (IV-OCT) is a high-resolution imaging method used to visualize the internal structures of walls of coronary arteries in vivo. However, accurate characterization of atherosclerotic plaques with gray-scale IV-OCT images is often limited by various intrinsic artifacts. In this study, we present an algorithm for characterizing lipid-rich plaques with a spectroscopic OCT technique based on a Gaussian center of mass (GCOM) metric. The GCOM metric, which reflects the absorbance properties of lipids, was validated using a lipid phantom. In addition, the proposed characterization method was successfully demonstrated in vivo using an atherosclerotic rabbit model and was found to have a sensitivity and specificity of 94.3% and 76.7% for lipid classification, respectively.
authors.affiliation: Hanyang University, Department of Biomedical Engineering, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea.
authors.forename: Hyeong Soo
authors.initials: HS
authors.lastname: Nam
authors.affiliation: Korea University Guro Hospital, Cardiovascular Center, 148 Gurodong-ro, Guro-gu, Seoul 08308 Republic of Korea.
authors.forename: Joon Woo
authors.initials: JW
authors.lastname: Song
authors.affiliation: Korea Advanced Institute of Science and Technology, Department of Mechanical Engineering, 291 Gwahang-no, Yuseong-gu, Daejeon 34141, Republic of Korea.
authors.forename: Sun-Joo
authors.initials: SJ
authors.lastname: Jang
authors.affiliation: Korea University Guro Hospital, Cardiovascular Center, 148 Gurodong-ro, Guro-gu, Seoul 08308 Republic of Korea.
authors.forename: Jae Joong
authors.initials: JJ
authors.lastname: Lee
authors.affiliation: Korea Advanced Institute of Science and Technology, Department of Mechanical Engineering, 291 Gwahang-no, Yuseong-gu, Daejeon 34141, Republic of Korea.
authors.forename: Wang-Yuhl
authors.initials: WY
authors.lastname: Oh
authors.affiliation: Korea University Guro Hospital, Cardiovascular Center, 148 Gurodong-ro, Guro-gu, Seoul 08308 Republic of Korea.
authors.forename: Jin Won
authors.initials: JW
authors.lastname: Kim
authors.affiliation: Hanyang University, Department of Biomedical Engineering, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea.
authors.forename: Hongki
authors.initials: H
authors.lastname: Yoo
mesh_terms: D000465:Algorithms; D000818:Animals; D050197:Atherosclerosis / Q000000981:diagnostic imaging*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D004195:Disease Models, Animal; D008055:Lipids / Q000737:chemistry*; D058226:Plaque, Atherosclerotic / Q000000981:diagnostic imaging*; D011817:Rabbits; D015203:Reproducibility of Results; D041623:Tomography, Optical Coherence
chemical_list: D008055:Lipids