title: An Evaluation of the OTA-OFC System in Clinical Practice: A Multi-Center Study With 90 Days Outcomes.
abstract: OBJECTIVE
  The purpose of this study is to evaluate the predictive ability of the Orthopedic Trauma-Open Fracture Classification (OTA-OFC) system in regards to short-term (90 days) outcomes of amputation, infection necessitating intravenous antibiotics, and wound healing in clinical practice across multiple centers.
  
  
  METHODS
  Prospective observational study.
  
  
  METHODS
  Academic and private practice.
  
  
  METHODS
  Patients with open fractures.
  
  
  METHODS
  None.
  
  
  METHODS
  OTA-OFC, amputations, IV antibiotics, and wound healing.
  
  
  RESULTS
  Three hundred seventy-three patients with a total of 419 open fractures were enrolled. Logistic regression to predict amputation demonstrated that arterial and skin injury were statistically significant contributors to the prediction of amputation. Bone loss and muscle injury were significant contributors to the prediction of readmission for IV antibiotics. None of the variables in the OTA-OFC were significant predictors of unhealed wounds.
  
  
  CONCLUSIONS
  Our study demonstrates the predictive value of the OTA-OFC regarding the short-term (90 days) outcomes of amputation and infection necessitating IV antibiotics and is another step towards the validation of the OTA-OFC in widespread clinical practice.
  
  
  METHODS
  Prognostic Level I. See Instructions for Authors for a complete description of levels of evidence.
authors.affiliation: *Department of Orthopedic Surgery, Warren Alpert Medical School, Brown University, Providence, RI; †Department of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA; and ‡Department of Orthopaedics, Harborview Medical Center, Seattle, WA.
authors.forename: Joey P
authors.initials: JP
authors.lastname: Johnson
authors.forename: Matthew
authors.initials: M
authors.lastname: Karam
authors.forename: Jessica
authors.initials: J
authors.lastname: Schisel
authors.forename: Julie
authors.initials: J
authors.lastname: Agel
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000671:Amputation, Surgical / Q000706:statistics & numerical data*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D017102:Fracture Healing; D005597:Fractures, Open / Q000175:diagnosis / Q000453:epidemiology* / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care / Q000379:methods / Q000706:statistics & numerical data; D011183:Postoperative Complications / Q000453:epidemiology* / Q000517:prevention & control; D015995:Prevalence; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D015599:Trauma Severity Indices; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents