title: Behavioral fever in ectothermic vertebrates.
abstract: Fever is an evolutionary conserved defense mechanism which is present in both endothermic and ectothermic vertebrates. Ectotherms in response to infection can increase their body temperature by moving to warmer places. This process is known as behavioral fever. In this review, we summarize the current knowledge on the mechanisms of induction of fever in mammals. We further discuss the evolutionary conserved mechanisms existing between fever of mammals and behavioral fever of ectothermic vertebrates. Finally, the experimental evidences supporting an adaptive value of behavioral fever expressed by ectothermic vertebrates are summarized.
authors.affiliation: Department of Evolutionary Immunology, Institute of Zoology, Jagiellonian University, Gronostajowa 9, 30-387, Krakow, Poland. Electronic address: krzysztof.rakus@uj.edu.pl.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Rakus
authors.affiliation: Immunology-Vaccinology, Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, University of Liège, Liège, Belgium. Electronic address: mronsmans@ulg.ac.be.
authors.forename: Maygane
authors.initials: M
authors.lastname: Ronsmans
authors.affiliation: Immunology-Vaccinology, Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, University of Liège, Liège, Belgium. Electronic address: a.vdplasschen@ulg.ac.be.
authors.forename: Alain
authors.initials: A
authors.lastname: Vanderplasschen
mesh_terms: D000818:Animals; D005075:Biological Evolution; D001831:Body Temperature; D001833:Body Temperature Regulation; D002490:Central Nervous System; D005334:Fever / Q000276:immunology*; D007113:Immunity, Innate; D009043:Motor Activity; D011453:Prostaglandins / Q000276:immunology; D014714:Vertebrates
chemical_list: D011453:Prostaglandins
keywords: Behavioral fever; Ectotherms; Fever; Innate immunity; Prostaglandins; Pyrogens