title: Comparison of N-acetylcysteine and cysteine in their ability to replenish intracellular cysteine by a specific fluorescent probe.
abstract: A specific fluorescent probe, designed by a substitution-rearrangement mechanism, can discriminate cysteine from other thiols. Using this probe, N-acetylcysteine is revealed to be superior to cysteine to replenish intracellular cysteine in cells.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. shiwen@iccas.ac.cn mahm@iccas.ac.cn.
authors.forename: Xinyuan
authors.initials: X
authors.lastname: He
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Wu
authors.forename: Wen
authors.initials: W
authors.lastname: Shi
authors.forename: Huimin
authors.initials: H
authors.lastname: Ma
mesh_terms: D000111:Acetylcysteine / Q000737:chemistry*; D002460:Cell Line; D003545:Cysteine / Q000031:analogs & derivatives* / Q000032:analysis* / Q000737:chemistry; D005456:Fluorescent Dyes / Q000032:analysis* / Q000138:chemical synthesis / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D061848:Optical Imaging
chemical_list: D005456:Fluorescent Dyes; D003545:Cysteine; D000111:Acetylcysteine