title: Rhodium/Yanphos-Catalyzed Asymmetric Interrupted Intramolecular Hydroaminomethylation of trans-1,2-Disubstituted Alkenes.
abstract: The first interrupted asymmetric hydroaminomethylation reaction was developed. The challenging trans-1,2-disubstituted olefins were employed as substrates, and a series of valuable chiral pyrrolidinones and pyrrolidines were obtained in high yields with high regioselectivities and excellent enantioselectivities. Several synthetic transformations were conducted, demonstrating the high synthetic utility of our method. A creative route for the synthesis of vernakalant and Enablex was also developed.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University , Wuhan 430072, P. R. China.
authors.forename: Caiyou
authors.initials: C
authors.lastname: Chen
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University , Wuhan 430072, P. R. China.
authors.forename: Shicheng
authors.initials: S
authors.lastname: Jin
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University , Wuhan 430072, P. R. China.
authors.forename: Zhefan
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University , Wuhan 430072, P. R. China.
authors.forename: Biao
authors.initials: B
authors.lastname: Wei
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University , Wuhan 430072, P. R. China.
authors.forename: Heng
authors.initials: H
authors.lastname: Wang
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University , Wuhan 430072, P. R. China.
authors.forename: Kai
authors.initials: K
authors.lastname: Zhang
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University , Wuhan 430072, P. R. China.
authors.forename: Hui
authors.initials: H
authors.lastname: Lv
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University , Wuhan 430072, P. R. China.
authors.forename: Xiu-Qin
authors.initials: XQ
authors.lastname: Dong
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University , Wuhan 430072, P. R. China.
authors.forename: Xumu
authors.initials: X
authors.lastname: Zhang