title: Laterality of repetitive finger movement performance and clinical features of Parkinson's disease.
abstract: Impairments in acoustically cued repetitive finger movement often emerge at rates near to and above 2Hz in persons with Parkinson's Disease (PD) in which some patients move faster (hastening) and others move slower (bradykinetic). The clinical features impacting this differential performance of repetitive finger movement remain unknown. The purpose of this study was to compare repetitive finger movement performance between the more and less affected side, and the difference in clinical ratings among performance groups. Forty-one participants diagnosed with idiopathic PD completed an acoustically cued repetitive finger movement task while "on" medication. Eighteen participants moved faster, 10 moved slower, and 13 were able to maintain the appropriate rate at rates above 2Hz. Clinical measures of laterality, disease severity, and the UPDRS were obtained. There were no significant differences between the more and less affected sides regardless of performance group. Comparison of disease severity, tremor, and rigidity among performance groups revealed no significant differences. Comparison of posture and postural instability scores revealed that the participants that demonstrated hastening had worse posture and postural instability scores. Consideration of movement rate during the clinical evaluation of repetitive finger movement may provide additional insight into varying disease features in persons with PD.
authors.affiliation: Department of Kinesiology, Iowa State University, Forker Building, 534 Wallace Road, Ames, IA 50011, United States; Department of Applied Physiology and Kinesiology, University of Florida, PO Box 118205, Gainesville, FL 32611, United States. Electronic address: esteg@iastate.edu.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Stegemöller
authors.affiliation: Department of Kinesiology, Iowa State University, Forker Building, 534 Wallace Road, Ames, IA 50011, United States.
authors.forename: Andrew
authors.initials: A
authors.lastname: Zaman
authors.affiliation: Department of Neurology, University of Minnesota, 717 Delaware St. SE, Minneapolis, MN 55445, United States.
authors.forename: Colum D
authors.initials: CD
authors.lastname: MacKinnon
authors.affiliation: Department of Kinesiology and Health Promotion, Troy University, Suite 112 Wright Hall, Troy, AL 36082, United States; Department of Applied Physiology and Kinesiology, University of Florida, PO Box 118205, Gainesville, FL 32611, United States.
authors.forename: Mark D
authors.initials: MD
authors.lastname: Tillman
authors.affiliation: Department of Applied Physiology and Kinesiology, University of Florida, PO Box 118205, Gainesville, FL 32611, United States; Center for Movement Disorders and Neurorestoration, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32610, United States.
authors.forename: Chris J
authors.initials: CJ
authors.lastname: Hass
authors.affiliation: Center for Movement Disorders and Neurorestoration, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32610, United States.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Okun
mesh_terms: D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use; D003463:Cues; D005260:Female; D005385:Fingers / Q000503:physiopathology; D007839:Functional Laterality / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology*; D009048:Motor Skills / Q000187:drug effects / Q000502:physiology*; D010300:Parkinson Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology*; D004856:Postural Balance / Q000187:drug effects / Q000502:physiology*; D013239:Stereotyped Behavior / Q000187:drug effects / Q000502:physiology
chemical_list: D000978:Antiparkinson Agents
keywords: Disease severity; Finger tapping; Rigidity; Tremor; UPDRS