title: Successful Treatment of Hepatitis C with Simeprevir, Sofosbuvir, and Ribavirin in an HIV Coinfected Liver Transplant Patient with Advanced Chronic Kidney Disease.
abstract: Although major advances have occurred in treating patients with hepatitis C virus (HCV) with the development of new direct-acting antivirals (DAAs), treatment of liver transplant recipients with HCV, human immunodeficiency virus (HIV) coinfection, and renal disease is challenging due to the lack of efficacy and safety data in this population. We report a case of successful HCV therapy in a postliver transplant HIV coinfected patient, with stage 4 chronic kidney disease, using an all-oral regimen of simeprevir, sofosbuvir, and ribavirin. The 51-year-old male achieved SVR24, and no specific HIV-related or transplant-related adverse events were documented during the treatment period. The new DAAs show promise for HIV coinfected patients and those with severe to end-stage renal disease (ESRD); however, robust clinical trials or large cohort studies will need to be conducted to confirm the efficacy and safety of these newer agents in this setting.
authors.affiliation: Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Anna
authors.initials: A
authors.lastname: Maruyama
authors.affiliation: Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Trana
authors.initials: T
authors.lastname: Hussaini
authors.affiliation: Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Nilufar
authors.initials: N
authors.lastname: Partovi
authors.affiliation: Division of Gastroenterology, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Siegfried R
authors.initials: SR
authors.lastname: Erb
authors.affiliation: Division of Gastroenterology, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Vladimir Marquez
authors.initials: VM
authors.lastname: Azalgara
authors.affiliation: Division of Nephrology, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Nadia
authors.initials: N
authors.lastname: Zalunardo
authors.affiliation: Division of AIDS, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Neora
authors.identifier: 0000-0003-4123-3698
authors.initials: N
authors.lastname: Pick
authors.affiliation: Division of AIDS, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Mark
authors.initials: M
authors.lastname: Hull
authors.affiliation: Division of Gastroenterology, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Eric M
authors.initials: EM
authors.lastname: Yoshida