title: What is known and unknown about chemotherapy-related cognitive impairment in patients with haematological malignancies and areas of needed research.
abstract: Cancer-related cognitive impairment (CRCI) is an important clinical problem for cancer patients and survivors. In this review, we summarize studies investigating the occurrence of impaired cognition in patients with haematological malignancies. Most published studies focus on survivors of childhood acute lymphoblastic leukaemia and primary central nervous system lymphoma. We also discuss studies conducted in acute myeloid leukaemia, myelodysplastic syndromes, chronic myeloid leukaemia, Hodgkin lymphoma (HL), non-HL and chronic lymphocytic leukaemia. Although research in this area is still emerging, it appears that a subset of chemotherapy-treated haematological malignancy survivors experience CRCI. Future research should focus on expanding the literature reviewed here with larger studies appropriately powered to assess cognition via objective and subjective measures in a longitudinal fashion to tease apart the impact of disease and the various forms of cancer treatment.
authors.affiliation: Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
authors.forename: Annalynn M
authors.initials: AM
authors.lastname: Williams
authors.affiliation: Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA.
authors.forename: Clive S
authors.initials: CS
authors.lastname: Zent
authors.affiliation: Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA.|Department of Surgery, Cancer Control, University of Rochester Medical Center, Rochester, NY, USA.
authors.forename: Michelle C
authors.initials: MC
authors.lastname: Janelsins
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003071:Cognition / Q000187:drug effects / Q000528:radiation effects; D060825:Cognitive Dysfunction / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D003131:Combined Modality Therapy / Q000009:adverse effects / Q000379:methods; D019468:Disease Management; D019337:Hematologic Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D006801:Humans; D012307:Risk Factors
chemical_list: D000970:Antineoplastic Agents
keywords: cancer; chemotherapy; chemotherapy-related cognitive impairment; cognition; haematological malignancy