title: Placental endoplasmic reticulum stress and acidosis: relevant aspects in gestational diabetes.
abstract: In this issue, Yung and colleagues (doi: 10.1007/s00125-016-4040-2 ) report endoplasmic reticulum stress in the placenta of patients with gestational diabetes mellitus. With the use of a trophoblast-like cell line, these authors identify putative mechanisms involved in, and treatments to prevent the induction of endoplasmic reticulum stress. Here, the relevance and possible implications of these findings and areas for further research are discussed.
authors.affiliation: Laboratory of Reproduction and Metabolism, Centro de Estudios Farmacológicos y Botánicos (CEFYBO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), School of Medicine, University of Buenos Aires, Paraguay 2155, 1121, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina. a.jawerbaum@gmail.com.
authors.forename: Alicia
authors.initials: A
authors.lastname: Jawerbaum
mesh_terms: D000138:Acidosis / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D016640:Diabetes, Gestational / Q000378:metabolism*; D059865:Endoplasmic Reticulum Stress / Q000235:genetics / Q000502:physiology*; D005260:Female; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy
keywords: Endoplasmic reticulum stress; Gestational diabetes mellitus; Glycolysis; Oxidative stress; Placenta