title: Noninvasively detecting Isocitrate dehydrogenase 1 gene status in astrocytoma by dynamic susceptibility contrast MRI.
abstract: To investigate the value of dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) in the noninvasive evaluation of isocitrate dehydrogenase (IDH) 1 gene status in astrocytoma.
  
  
  
  The preoperative DSC MRI data of 91 lesions with pathologically confirmed astrocytoma were retrospectively analyzed. MR examination was performed on a 3T MRI scanner. The normalized maximum ratios of relative cerebral blood volume (rCBV ratio) of tumor parenchyma were measured. The enrolled astrocytoma patients were divided into six groups according to the World Health Organization (WHO) classification method and IDH1 gene status. The differences in the rCBV ratio of tumor parenchyma between the IDH1 gene mutant and wildtype groups of WHO grade II, III, and IV were compared and plotted receiver operating characteristic (ROC) curves were drawn.
  
  
  
  The IDH1 gene mutant and wildtype groups of WHO grade II, III, and IV astrocytoma showed differences in the rCBV ratio (P = 0.005, 0.045, and 0.005, respectively). In WHO grade II, III, and IV astrocytoma, the area under the ROC curve was respectively 0.83, 0.86, and 0.94. The cutoff value of the rCBV ratio was respectively 2.20, 3.14, and 5.63.
  
  
  
  The rCBV ratio value provided by DSC MRI provides a new potential imaging method for the noninvasive evaluation of the IDH1 status in astrocytoma.
  
  
  
  3 J. Magn. Reson. Imaging 2017;45:492-499.
authors.affiliation: Department of Radiology, Shuguang Hospital Affiliated with Shanghai University of Traditional Chinese Medicine, Shanghai, P.R. China.
authors.forename: WenLi
authors.initials: W
authors.lastname: Tan
authors.affiliation: Department of Neuropathology, Huashan Hospital, Fudan University, Shanghai, P.R. China.
authors.forename: Ji
authors.initials: J
authors.lastname: Xiong
authors.affiliation: Department of Radiology, Hainan General Hospital, Hainan Province, P.R. China.
authors.forename: WeiYuan
authors.initials: W
authors.lastname: Huang
authors.affiliation: Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, P.R. China.
authors.forename: JinSong
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Radiology, Shuguang Hospital Affiliated with Shanghai University of Traditional Chinese Medicine, Shanghai, P.R. China.
authors.forename: SongHua
authors.initials: S
authors.lastname: Zhan
authors.affiliation: Department of Radiology, Huashan Hospital, Fudan University, Shanghai, P.R. China.
authors.forename: DaoYing
authors.initials: D
authors.lastname: Geng
mesh_terms: D000328:Adult; D001254:Astrocytoma / Q000000981:diagnostic imaging* / Q000201:enzymology*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000201:enzymology*; D003287:Contrast Media; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000378:metabolism*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D057054:Molecular Imaging / Q000379:methods; D015588:Observer Variation; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014018:Tissue Distribution
chemical_list: D014408:Biomarkers, Tumor; D003287:Contrast Media; D007521:Isocitrate Dehydrogenase
keywords: astrocytoma; dynamic susceptibility contrast; isocitrate dehydrogenase 1 gene; magnetic resonance imaging