title: Preclinical Toxicological Study of Release-Active Preparations for Prediction of Their Pharmacological Activity and Side Effects.
abstract: We studied chronic toxicity of a few release-active preparations: Dietressa (release-active preparation of affinity-purified antibodies to type 1 cannabinoid receptor), Divasa (releaseactive preparation containing a combination of affinity-purified antibodies to brain-specific S-100 protein and endothelial NO-synthase), Cardostin (release-active preparation containing a combination of affinity-purified antibodies to C-terminal fragment of angiotensin II type 1 receptor and endothelial NO-synthase), and Bation (release-active preparation containing a combination of affinity-purified antibodies to IFN-γ and CD4). We evaluated not only side and toxic effects, but also the relationships between these effects and pharmacological activities of the preparations. The data of preclinical toxicological studies of the release-active preparations can be used for prediction of their pharmacological activity.
authors.affiliation: Materia Medica Holding, Moscow, Russia. zhavbertes@materiamedica.ru.
authors.forename: E S
authors.initials: ES
authors.lastname: Zhavbert
authors.affiliation: Materia Medica Holding, Moscow, Russia.
authors.forename: E I
authors.initials: EI
authors.lastname: Surkova
authors.affiliation: Materia Medica Holding, Moscow, Russia.
authors.forename: N N
authors.initials: NN
authors.lastname: Yakovleva
authors.affiliation: Materia Medica Holding, Moscow, Russia.
authors.forename: Yu L
authors.initials: YL
authors.lastname: Dugina
authors.affiliation: Materia Medica Holding, Moscow, Russia.
authors.forename: O I
authors.initials: OI
authors.lastname: Epshtein
authors.affiliation: Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia.
authors.forename: L I
authors.initials: LI
authors.lastname: Bugaeva
authors.affiliation: Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia.
authors.forename: S A
authors.initials: SA
authors.lastname: Lebedeva
authors.affiliation: Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia.
authors.forename: V I
authors.initials: VI
authors.lastname: Petrov
mesh_terms: D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D001067:Appetite Depressants / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D005260:Female; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats
chemical_list: D000906:Antibodies; D001067:Appetite Depressants; C000605985:Dietressa
keywords: release-active drugs; toxicological studies