title: Glycan and lectin biosensors.
abstract: A short description about the importance of glycan biorecognition in physiological (blood cell type) and pathological processes (infections by human and avian influenza viruses) is provided in this review. Glycans are described as much better information storage media, compared to proteins or DNA, due to the extensive variability of glycan structures. Techniques able to detect an exact glycan structure are briefly discussed with the main focus on the application of lectins (glycan-recognising proteins) in the specific analysis of glycans still attached to proteins or cells/viruses. Optical, electrochemical, piezoelectric and micromechanical biosensors with immobilised lectins or glycans able to detect a wide range of analytes including whole cells/viruses are also discussed.
authors.affiliation: Institute of Chemistry, Slovak Academy of Sciences, Dubravska cesta 9, 845 38 Bratislava, Slovakia.
authors.forename: Štefan
authors.initials: Š
authors.lastname: Belický
authors.affiliation: Institute of Chemistry, Slovak Academy of Sciences, Dubravska cesta 9, 845 38 Bratislava, Slovakia.
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Katrlík
authors.affiliation: Institute of Chemistry, Slovak Academy of Sciences, Dubravska cesta 9, 845 38 Bratislava, Slovakia Jan.Tkac@savba.sk.
authors.forename: Ján
authors.initials: J
authors.lastname: Tkáč
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D037102:Lectins / Q000737:chemistry* / Q000378:metabolism; D049329:Nanostructures / Q000737:chemistry; D011134:Polysaccharides / Q000737:chemistry* / Q000378:metabolism
chemical_list: D037102:Lectins; D011134:Polysaccharides
keywords: biosensors; glycans; glycomics; lectins; prostate-specific antigen (PSA); sialic acid (SA)