title: Clinical Overlap of Multiple Sclerosis and Autoimmune Hepatitis: Three Cases.
abstract: Multiple sclerosis (MS) is an autoimmune, inflammatory disease characterized by demyelination and axonal degeneration in the central nervous system. MS is the second major cause of disability following trauma, and is mostly seen between the ages of 20 - 40 years and in women. Autoimmune hepatitis (AH) is a chronic disease characterized by hypergammaglobulinemia, high levels of transaminases, presence of antibodies, and histologically by the necroinflammatory process with interface hepatitis. In AH, the etiological agent of the disease and the cause of liver injury remain unknown. MS may be associated with AH, autoimmune thyroiditis, and type 1 diabetes mellitus (DM). In literature, 8 cases with overlap of MS and AH have been reported. In this report, we present 3 cases which were detected with overlap of MS and AH, and are very rare condition in literature.
authors.affiliation: Department of Neurology, Ufuk University, Faculty of Medicine, Ankara, Turkey.
authors.forename: Refah
authors.initials: R
authors.lastname: Sayin
authors.affiliation: Department of Neurology, Yuzuncu Yil University, Faculty of Medicine, Van, Turkey.
authors.forename: Alper
authors.initials: A
authors.lastname: Gokgul
authors.affiliation: Department of Internal Medicine, Yuzuncu Yil University, Faculty of Medicine, Van, Turkey.
authors.forename: Senar
authors.initials: S
authors.lastname: Ebinc
authors.affiliation: Department of Internal Medicine, Yuzuncu Yil University, Faculty of Medicine, Van, Turkey.
authors.forename: Ahmet Cumhur
authors.initials: AC
authors.lastname: Dulger
authors.affiliation: Department of Neurology, Yuzuncu Yil University, Faculty of Medicine, Van, Turkey.
authors.forename: Temel
authors.initials: T
authors.lastname: Tombul
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D001379:Azathioprine / Q000627:therapeutic use; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D019693:Hepatitis, Autoimmune / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D008099:Liver / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D001323:Autoantibodies; D001324:Autoantigens; D001379:Azathioprine