title: Immunotherapy for opportunistic infections: Current status and future perspectives.
abstract: The outcome after allogeneic haematopoietic stem cell transplantation (allo-HSCT) has significantly improved during the last decades. However, opportunistic infections such as viral and mold infections are still a major obstacle for cure. Within this field, adoptive T cell therapy against pathogens is a promising treatment approach. Recently, the techniques to develop T cell products including pathogen-specific T cells have been sophisticated and are now available in accordance to good manufacturing practice (GMP). Here, we aim to summarize current knowledge about adoptive T cell therapy against viral and mold infections.
authors.affiliation: a Department of Haematopoietic Stem Cell Transplantation , National Cancer Center Hospital , Tokyo , Japan.|b Department of Internal Medicine II , Division of Hematology/Oncology, University Hospital of Würzburg , Würzburg , Germany.
authors.forename: Shigeo
authors.initials: S
authors.lastname: Fuji
authors.affiliation: b Department of Internal Medicine II , Division of Hematology/Oncology, University Hospital of Würzburg , Würzburg , Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Löffler
authors.affiliation: b Department of Internal Medicine II , Division of Hematology/Oncology, University Hospital of Würzburg , Würzburg , Germany.
authors.forename: Hermann
authors.initials: H
authors.lastname: Einsele
authors.affiliation: b Department of Internal Medicine II , Division of Hematology/Oncology, University Hospital of Würzburg , Würzburg , Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Kapp
mesh_terms: D001228:Aspergillosis / Q000276:immunology / Q000628:therapy; D003586:Cytomegalovirus Infections / Q000276:immunology / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000009:adverse effects / Q000379:methods / Q000639:trends; D009894:Opportunistic Infections / Q000276:immunology / Q000382:microbiology / Q000628:therapy* / Q000821:virology; D013601:T-Lymphocytes / Q000276:immunology / Q000637:transplantation*
keywords: adoptive immunotherapy; aspergillus; mold infection; viral infection