title: Transcription factor activity of estrogen receptor α activation upon nonylphenol or bisphenol A treatment enhances the in vitro proliferation, invasion, and migration of neuroblastoma cells.
abstract: Many kinds of endocrine-disrupting chemicals (EDCs), for example, the environmental estrogens bisphenol A and nonylphenol, may regulate the activity of estrogen receptor α (ERα) and therefore induce potential disruption of normal endocrine function. However, the involvement of EDCs in human cancers, especially in endocrine-related cancer neuroblastoma regulation, is not very clear. In this work, results showed that upon bisphenol A or nonylphenol treatment, the transcription factor activity of ERα was significantly increased in neuroblastoma cell line SH-SY5Y. Bisphenol A and nonylphenol could enhance ERα activity via recruiting it to the target gene promoter. Furthermore, treatment of bisphenol A and nonylphenol enhanced the in vitro proliferation, invasion, and migration ability of neuroblastoma cells. By investigating the role of EDC-induced ERα upregulation, our data extend the understanding of the function of EDCs and further suggest that ERα might be a potential therapeutic target in human neuroblastoma treatment.
authors.affiliation: Department of Pharmacy, General Hospital of Shenyang Military Area Command, Shenyang, People's Republic of China.
authors.forename: Hongda
authors.initials: H
authors.lastname: Ma
authors.affiliation: Department of Pharmacy, Women & Infants Hospital of Zhengzhou, Zhengzhou, People's Republic of China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Yao
authors.affiliation: Department of Pharmacy, General Hospital of Shenyang Military Area Command, Shenyang, People's Republic of China.
authors.forename: Changli
authors.initials: C
authors.lastname: Wang
authors.affiliation: Shaanxi Institute of Pediatric Disease, Xi'an Children's Hospital, Xi'an, People's Republic of China.
authors.forename: Liyu
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Institute of Biotechnology, Chinese Military Medical Science Academy, Beijing, People's Republic of China.
authors.forename: Long
authors.initials: L
authors.lastname: Cheng
authors.affiliation: School of Life Science, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
authors.forename: Yiren
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Institute of Toxicology and Pharmacology, Chinese Military Medical Science Academy, Beijing, People's Republic of China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.affiliation: Institute of Toxicology and Pharmacology, Chinese Military Medical Science Academy, Beijing, People's Republic of China.
authors.forename: Erguang
authors.initials: E
authors.lastname: Liang
authors.affiliation: Department of Pharmacy, General Hospital of Shenyang Military Area Command, Shenyang, People's Republic of China.
authors.forename: Hui
authors.initials: H
authors.lastname: Jia
authors.affiliation: Institute of Biotechnology, Chinese Military Medical Science Academy, Beijing, People's Republic of China.
authors.forename: Qinong
authors.initials: Q
authors.lastname: Ye
authors.affiliation: Department of Pharmacy, General Hospital of Shenyang Military Area Command, Shenyang, People's Republic of China.
authors.forename: Mingxiao
authors.initials: M
authors.lastname: Hou
authors.affiliation: Department of Pharmacy, General Hospital of Shenyang Military Area Command, Shenyang, People's Republic of China.
authors.forename: Fan
authors.initials: F
authors.lastname: Feng
keywords: bisphenol A and nonylphenol; endocrine-disrupting chemicals; environmental estrogens; neuroblastoma; proliferation and metastasis