title: Gold-catalysed facile access to indene scaffolds via sequential C-H functionalization and 5-endo-dig carbocyclization.
abstract: A concise synthesis of functionalized indene derivatives via the gold(i)-catalysed cascade C-H functionalization/conia-ene type reaction of electron-rich aromatics with o-alkynylaryl α-diazoesters has been developed. In this transformation, the gold catalyst not only catalysed the formation of the zwitterionic intermediate via intermolecular C-H functionalization but promoted the subsequent intramolecular 5-endo-dig cyclization via activation of alkynes. The reaction is characterized by high chemo- and site-selectivity, readily available starting materials, nice functional-group tolerance and mild reaction conditions.
authors.affiliation: Shanghai Key Laboratory of Green Chemistry and Chemical Process, School of Chemistry and Molecular Engineering, East China Normal University, 3663 N. Zhongshan Road, Shanghai 200062, China. lliu@chem.ecnu.edu.cn jlzhang@chem.ecnu.edu.cn.
authors.forename: Ben
authors.initials: B
authors.lastname: Ma
authors.forename: Ziang
authors.initials: Z
authors.lastname: Wu
authors.forename: Ben
authors.initials: B
authors.lastname: Huang
authors.forename: Lu
authors.initials: L
authors.lastname: Liu
authors.forename: Junliang
authors.initials: J
authors.lastname: Zhang