title: Detection and genetic characterization of hepatitis E virus (HEV) genotype 3 subtype c in wild boars in Italy.
abstract: Hepatitis E virus (HEV) was detected in stools collected from wild boars in Italy, with an overall prevalence of 1.5 % (3/196). The sequence of a ~3.0-kb portion at the 3' end of the genome of one such strain, HEV/WB/P6-15/ITA, was determined. In the full-length ORF2, which encodes the capsid protein, the virus was genetically closest to wild boar and human HEV strains currently classified as genotype 3 subtype c. Interestingly, the 3' end of ORF2 of the WB/P6-15/ITA matched the 340-nucleotide (nt) sequence (94.0 % nt identity) of the human strain PeGe, identified in 2015 from a patient with acute hepatitis E in Genoa, Italy, suggesting that similar HEV strains are circulating in the same geographical setting in humans and animals.
authors.affiliation: Faculty of Veterinary Medicine, Università degli Studi di Teramo, University of Teramo, Piazza Aldo Moro, 45, 64100, Teramo, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Di Profio
authors.affiliation: Faculty of Veterinary Medicine, Università degli Studi di Teramo, University of Teramo, Piazza Aldo Moro, 45, 64100, Teramo, Italy.
authors.forename: Irene
authors.initials: I
authors.lastname: Melegari
authors.affiliation: Faculty of Veterinary Medicine, Università degli Studi di Teramo, University of Teramo, Piazza Aldo Moro, 45, 64100, Teramo, Italy.
authors.forename: Vittorio
authors.initials: V
authors.lastname: Sarchese
authors.affiliation: Istituto Zooprofilattico Sperimentale del Piemonte, della Liguria e della Valle d'Aosta, Struttura Complessa Valle d'Aosta con annesso Centro di Referenza Nazionale per le Malattie degli Animali Selvatici (CeRMAS), Torino, Italy.
authors.forename: Serena
authors.initials: S
authors.lastname: Robetto
authors.affiliation: Faculty of Veterinary Medicine, Università degli Studi di Teramo, University of Teramo, Piazza Aldo Moro, 45, 64100, Teramo, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Marruchella
authors.affiliation: Istituto Zooprofilattico Sperimentale del Piemonte, della Liguria e della Valle d'Aosta, Struttura Complessa Valle d'Aosta con annesso Centro di Referenza Nazionale per le Malattie degli Animali Selvatici (CeRMAS), Torino, Italy.
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Bona
authors.affiliation: Istituto Zooprofilattico Sperimentale del Piemonte, della Liguria e della Valle d'Aosta, Struttura Complessa Valle d'Aosta con annesso Centro di Referenza Nazionale per le Malattie degli Animali Selvatici (CeRMAS), Torino, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Orusa
authors.affiliation: Faculty of Veterinary Medicine, Università Aldo Moro di Bari, Valenzano, Italy.
authors.forename: Vito
authors.initials: V
authors.lastname: Martella
authors.affiliation: Faculty of Veterinary Medicine, Università degli Studi di Teramo, University of Teramo, Piazza Aldo Moro, 45, 64100, Teramo, Italy.
authors.forename: Fulvio
authors.initials: F
authors.lastname: Marsilio
authors.affiliation: Faculty of Veterinary Medicine, Università degli Studi di Teramo, University of Teramo, Piazza Aldo Moro, 45, 64100, Teramo, Italy. bdimartino@unite.it.
authors.forename: Barbara
authors.initials: B
authors.lastname: Di Martino
mesh_terms: D000818:Animals; D036022:Capsid Proteins / Q000235:genetics; D016000:Cluster Analysis; D005243:Feces / Q000821:virology; D005838:Genotype; D016751:Hepatitis E / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D016752:Hepatitis E virus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D007558:Italy / Q000453:epidemiology; D017720:Molecular Epidemiology; D010802:Phylogeny; D015995:Prevalence; D012367:RNA, Viral / Q000235:genetics; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D034421:Sus scrofa / Q000821:virology*; D013552:Swine; D013553:Swine Diseases / Q000453:epidemiology / Q000821:virology*
chemical_list: D036022:Capsid Proteins; D012367:RNA, Viral