title: Ageing and ocular surface immunity.
abstract: The prevalence of ocular surface immunopathologies is enhanced in the elderly. This increased prevalence has been attributed to age-related dysregulation of innate and adaptive immune system responses. Age-related changes in ocular surface immunity have similar and distinct characteristics to those changes seen in other mucosal tissues. This mini review provides a brief outline of key findings in the field of ocular ageing, draws comparisons with other mucosal tissues and, finally, discusses age-related changes in the context of immunopathogenesis of infectious keratitis and dry eye disease, two of the most common inflammatory disorders of the ocular surface.
authors.affiliation: Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Alireza
authors.initials: A
authors.lastname: Mashaghi
authors.affiliation: Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Jiaxu
authors.initials: J
authors.lastname: Hong
authors.affiliation: Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Sunil K
authors.initials: SK
authors.lastname: Chauhan
authors.affiliation: Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Reza
authors.initials: R
authors.lastname: Dana
mesh_terms: D056704:Adaptive Immunity / Q000502:physiology; D000375:Aging / Q000276:immunology*; D015352:Dry Eye Syndromes / Q000276:immunology / Q000503:physiopathology; D005123:Eye / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology; D007638:Keratoconjunctivitis Sicca / Q000276:immunology / Q000503:physiopathology
keywords: Immunology; Infection; Inflammation; Ocular surface