title: Neuroprotective Fatty Acids from the Stem Bark of Sorbus commixta.
abstract: Phytochemical investigation of the bark from the stems of Sorbus commixta led to the isolation and characterization of a new fatty acid, sorcomic acid (1), along with nine known analogues (2-10). The structure of the new compound (1) was determined through NMR ((1)H and (13)C NMR, HSQC, HMBC, and NOESY), MS, and specific optical rotation. The known compounds (2-10) were identified by comparison of their spectroscopic data with those in the literature. The biological activities of all the isolated compounds (1-10) were evaluated: compounds 1, 5, and 7 potently induced NGF secretion from C6 glioma cells (233.40 ± 12.82, 194.40 ± 8.05, and 185.74 ± 10.25 %, respectively) and compound 10 reduced NO levels with an IC50 value of 71.25 μM in murine microglia BV2 cells stimulated by LPS.
authors.affiliation: Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, 2066 Seobu-ro, Jangan-ku, Suwon, 16419, Republic of Korea.
authors.forename: Chung Sub
authors.initials: CS
authors.lastname: Kim
authors.affiliation: Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, 2066 Seobu-ro, Jangan-ku, Suwon, 16419, Republic of Korea.
authors.forename: Won Se
authors.initials: WS
authors.lastname: Suh
authors.affiliation: Gachon Institute of Pharmaceutical Science, Gachon University, Incheon, 21936, Republic of Korea.|College of Pharmacy, Gachon University, #191, Hambakmoero, Yeonsu-gu, Incheon, 21936, Republic of Korea.
authors.forename: Lalita
authors.initials: L
authors.lastname: Subedi
authors.affiliation: Gachon Institute of Pharmaceutical Science, Gachon University, Incheon, 21936, Republic of Korea.|College of Pharmacy, Gachon University, #191, Hambakmoero, Yeonsu-gu, Incheon, 21936, Republic of Korea.
authors.forename: Sun Yeou
authors.initials: SY
authors.lastname: Kim
authors.affiliation: Korea Research Institute of Chemical Technology, Daejeon, 34114, Republic of Korea.
authors.forename: Sang Un
authors.initials: SU
authors.lastname: Choi
authors.affiliation: Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, 2066 Seobu-ro, Jangan-ku, Suwon, 16419, Republic of Korea. krlee@skku.edu.
authors.forename: Kang Ro
authors.initials: KR
authors.lastname: Lee
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D005227:Fatty Acids / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D020932:Nerve Growth Factor / Q000378:metabolism*; D018696:Neuroprotective Agents / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology*; D009569:Nitric Oxide / Q000378:metabolism; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D051381:Rats; D031994:Sorbus / Q000737:chemistry*
chemical_list: D005227:Fatty Acids; D018696:Neuroprotective Agents; D010936:Plant Extracts; D009569:Nitric Oxide; D020932:Nerve Growth Factor
keywords: Anti-neuroinflammation; Fatty acids; Neuroprotection; Rosaceae; Sorbus commixta