title: Bifunctional Organo/Metal Cooperatively Catalyzed [3 + 2] Annulation of para-Quinone Methides with Vinylcyclopropanes: Approach to Spiro[4.5]deca-6,9-diene-8-ones.
abstract: A novel [3 + 2] annulation between para-quinone methides and vinylcyclopropanes for the synthesis of spiro[4.5]deca-6,9-diene-8-ones has been described. The palladium and phosphine-thiourea cooperative catalysis system played an important role in high yields and diastereoselectivities. The reaction exhibited good functional group tolerance and scalability.
authors.affiliation: State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry, China Pharmaceutical University , Nanjing, 210009, P. R. China.
authors.forename: Zhenbo
authors.initials: Z
authors.lastname: Yuan
authors.affiliation: State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry, China Pharmaceutical University , Nanjing, 210009, P. R. China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Wei
authors.affiliation: State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry, China Pharmaceutical University , Nanjing, 210009, P. R. China.
authors.forename: Aijun
authors.initials: A
authors.lastname: Lin
authors.affiliation: State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry, China Pharmaceutical University , Nanjing, 210009, P. R. China.
authors.forename: Hequan
authors.initials: H
authors.lastname: Yao