title: Comparison of analytical techniques for the identification of bioactive compounds from natural products.
abstract: Covering: 2000 to 2016Natural product extracts are a rich source of bioactive compounds. As a result, the screening of natural products for the identification of novel biologically active metabolites has been an essential part of several drug discovery programs. It is estimated that more than 70% of all drugs approved from 1981 and 2006, were either derived from or structurally similar to nature based compounds indicating the necessity for the development of a rapid method for the identification of novel compounds from plant extracts. The screening of biological matrices for the identification of novel modulators is nevertheless still challenging. In this review we discuss current techniques in phytochemical analysis and the identification of biologically active components.
authors.affiliation: Laboratory of Clinical Investigation, Biomedical Research Center, 8C232, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, Maryland 21224, USA. moaddelru@mail.nih.gov.
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Cieśla
authors.forename: Ruin
authors.initials: R
authors.lastname: Moaddel
mesh_terms: D001688:Biological Products / Q000737:chemistry*; D055808:Drug Discovery; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry
chemical_list: D001688:Biological Products; D010936:Plant Extracts