title: Age-Dependent Changes in Na(+),K(+)-ATPase Activity and Lipid Peroxidation in Membranes of Erythrocytes during Cardiosclerosis Development in Rats.
abstract: Activity of Na(+),K(+)-ATPase was measured in erythrocyte ghosts of 4- and 12-month-old rats, intact and with postinfarction cardiosclerosis. Enhanced accumulation of secondary LPO products and reduced activity of Na(+),K(+)-ATPase were observed in erythrocyte ghosts of 12-month-old rats. The development of postinfarction cardiosclerosis in 4-month-old rats was accompanied by enhanced accumulation of LPO products and decreased activity of Na(+),K(+)-ATPase. In comparison with young rats with postinfarction cardiosclerosis, 12-month-old rats with this pathology were characterized by less pronounced decrease in Na(+),K(+)-ATPase activity and increase in accumulation of LPO products in comparison with intact control.
authors.affiliation: Research Institute of Cardiology, Tomsk, Russia. rebrova@cardio-tomsk.ru.
authors.forename: T Yu
authors.initials: TY
authors.lastname: Rebrova
authors.affiliation: Research Institute of Cardiology, Tomsk, Russia.
authors.forename: S A
authors.initials: SA
authors.lastname: Afanasiev
authors.affiliation: Research Institute of Cardiology, Tomsk, Russia.
authors.forename: S V
authors.initials: SV
authors.lastname: Popov
mesh_terms: D000375:Aging; D000818:Animals; D004910:Erythrocyte Membrane / Q000201:enzymology*; D006331:Heart Diseases / Q000097:blood*; D015227:Lipid Peroxidation; D008297:Male; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
chemical_list: D000254:Sodium-Potassium-Exchanging ATPase
keywords: Na+,K+-ATPase; age; lipid peroxidation; postinfarction cardiosclerosis