title: Jun N-terminal kinase signaling makes a face.
abstract: decapentaplegic (dpp), the Drosophila ortholog of BMP 2/4, directs ventral adult head morphogenesis through expression in the peripodial epithelium of the eye-antennal disc. This dpp expressing domain exerts effects both on the peripodial epithelium, and the underlying disc proper epithelium. We have uncovered a role for the Jun N-terminal kinase (JNK) pathway in dpp-mediated ventral head development. JNK activity is required for dpp's action on the disc proper, but in the absence of dpp expression, excessive JNK activity is produced, leading to specific loss of maxillary palps. In this review we outline our hypotheses on how dpp acts by both short range and longer range mechanisms to direct head morphogenesis and speculate on the dual role of JNK signaling in this process. Finally, we describe the regulatory control of dpp expression in the eye-antennal disc, and pose the problem of how the various expression domains of a secreted protein can be targeted to their specific functions.
authors.affiliation: a Division of Cell and Gene Therapies , Center for Biologics Evaluation and Research, Food and Drug Administration , Silver Spring , MD , USA.
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Hursh
authors.affiliation: a Division of Cell and Gene Therapies , Center for Biologics Evaluation and Research, Food and Drug Administration , Silver Spring , MD , USA.
authors.forename: Brian G
authors.initials: BG
authors.lastname: Stultz
authors.affiliation: b Ischemic/Hypoxic Disease Institute , Department of Physiology , Seoul National University College of Medicine , Seoul , Republic of Korea.
authors.forename: Sung Yeon
authors.initials: SY
authors.lastname: Park
mesh_terms: D000818:Animals; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000254:growth & development* / Q000378:metabolism*; D006257:Head / Q000254:growth & development; D060227:Imaginal Discs; D048670:MAP Kinase Kinase 4 / Q000378:metabolism; D009024:Morphogenesis; D015398:Signal Transduction
chemical_list: D029721:Drosophila Proteins; C064196:dpp protein, Drosophila; D048670:MAP Kinase Kinase 4
keywords: Bone Morphogenetic Protein (BMP); Drosophila; Jun N-terminal Kinase (JNK); decapentaplegic (dpp); head morphogenesis