title: Unusual Presentation of an Adenocarcinoma of the Lung Metastasizing to the Mandible, Including Molecular Analysis and a Review of the Literature.
abstract: Lung cancer is the most frequent cause of cancer-related death worldwide. Metastases of non-small cell lung carcinoma to the oral and maxillofacial region are rare. Thus, the diagnosis of a metastatic lesion in the oral cavity is challenging to the clinician and to the pathologist. This report presents a case of a 72-year-old man with metastatic lung adenocarcinoma located in the posterior mandibular region. Next-generation sequencing analysis showed no important mutations in the relevant genes except in the TP53 tumor suppressor gene.
authors.affiliation: Professor and Department Head, Department of Oral Pathology, Faculty of Dentistry, Gazi University, Ankara, Turkey.
authors.forename: Sibel Elif
authors.initials: SE
authors.lastname: Gultekin
authors.affiliation: Associate Professor, Department of Oral Pathology, Faculty of Dentistry, Gazi University, Ankara, Turkey. Electronic address: bsenguven@gazi.edu.tr.
authors.forename: Burcu
authors.initials: B
authors.lastname: Senguven
authors.affiliation: Associate Professor, Department of Pathology, Faculty of Medicine, Gazi University, Ankara, Turkey.
authors.forename: Ipek
authors.initials: I
authors.lastname: Isik Gonul
authors.affiliation: PhD Student, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gazi University, Ankara, Turkey.
authors.forename: Begum
authors.initials: B
authors.lastname: Okur
authors.affiliation: Professor and Department Head, Department of Pathology, Faculty of Medicine, University of Cologne, Cologne, Germany.
authors.forename: Reinhard
authors.initials: R
authors.lastname: Buettner
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000556:secondary*; D000368:Aged; D001706:Biopsy; D017809:Fatal Outcome; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D008339:Mandibular Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D011862:Radiography, Panoramic