title: Serum uric acid levels and inflammatory markers with respect to dipping status: A retrospective analysis of hypertensive patients with or without chronic kidney disease.
abstract: BACKGROUND
  The aim of this study was to evaluate serum uric acid levels, inflammatory markers [C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR)] and mean platelet volume (MPV) among hypertensive patients with or without chronic kidney disease (CKD) with respect to dipping status.
  
  
  METHODS
  A total of 432 hypertensive patients with (n = 340) or without (n = 92) CKD who had ambulatory blood pressure monitoring recordings were included. Correlation of serum uric acid levels with inflammatory markers (CRP, PLR, NLR) was evaluated as was the logistic regression analysis for determinants of nondipper pattern.
  
  
  RESULTS
  Nondipper pattern was noted in 65.2% and 79.7% of non-CKD and CKD patients, respectively. Multivariate logistic regression analysis revealed that only serum uric acid (OR, 2.69; 95% CI, 1.60 to 4.52; p = 0.000), MPV (OR, 1.81; 95% CI, 1.30 to 2.53; p = 0.000), PLR (OR, 0.98; 95% CI, 0.97 to 0.99; p = 0.000), and serum albumin (OR, 0.42; 95% CI, 0.19 to 0.93; p = 0.031) were significant determinants of nondipper pattern in the overall study population.
  
  
  CONCLUSIONS
  In conclusion, our findings revealed higher prevalence of nondipper pattern in hypertensive patients with than without CKD and significantly higher levels for uric acid, CRP, MPV, PLR, and NLR among nondipper than dipper hypertensive patients with CKD. High levels for uric acid and MPV and lower levels for PLR and serum albumin were noted as significant determinants of nondipper pattern among hypertensive patients.
authors.affiliation: a Department of Nephrology , Sisli Etfal Training and Research Hospital , Istanbul , Turkey.
authors.forename: Elbis
authors.initials: E
authors.lastname: Ahbap
authors.affiliation: a Department of Nephrology , Sisli Etfal Training and Research Hospital , Istanbul , Turkey.
authors.forename: Tamer
authors.initials: T
authors.lastname: Sakaci
authors.affiliation: b Department of Internal Medicine, Division of Nephrology , RecepTayyip Erdogan University Faculty of Medicine , Rize , Turkey.
authors.forename: Ekrem
authors.initials: E
authors.lastname: Kara
authors.affiliation: a Department of Nephrology , Sisli Etfal Training and Research Hospital , Istanbul , Turkey.
authors.forename: Tuncay
authors.initials: T
authors.lastname: Sahutoglu
authors.affiliation: a Department of Nephrology , Sisli Etfal Training and Research Hospital , Istanbul , Turkey.
authors.forename: Yener
authors.initials: Y
authors.lastname: Koc
authors.affiliation: a Department of Nephrology , Sisli Etfal Training and Research Hospital , Istanbul , Turkey.
authors.forename: Taner
authors.initials: T
authors.lastname: Basturk
authors.affiliation: a Department of Nephrology , Sisli Etfal Training and Research Hospital , Istanbul , Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Sevinc
authors.affiliation: a Department of Nephrology , Sisli Etfal Training and Research Hospital , Istanbul , Turkey.
authors.forename: Cuneyt
authors.initials: C
authors.lastname: Akgol
authors.affiliation: a Department of Nephrology , Sisli Etfal Training and Research Hospital , Istanbul , Turkey.
authors.forename: Barıs
authors.initials: B
authors.lastname: Hasbal
authors.affiliation: a Department of Nephrology , Sisli Etfal Training and Research Hospital , Istanbul , Turkey.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Isleem
authors.affiliation: a Department of Nephrology , Sisli Etfal Training and Research Hospital , Istanbul , Turkey.
authors.forename: Perin
authors.initials: P
authors.lastname: Nazif
authors.affiliation: a Department of Nephrology , Sisli Etfal Training and Research Hospital , Istanbul , Turkey.
authors.forename: Feyza Bayraktar
authors.initials: FB
authors.lastname: Caglayan
authors.affiliation: a Department of Nephrology , Sisli Etfal Training and Research Hospital , Istanbul , Turkey.
authors.forename: Abdulkadir
authors.initials: A
authors.lastname: Unsal
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D018660:Blood Pressure Monitoring, Ambulatory / Q000379:methods; D002097:C-Reactive Protein / Q000032:analysis*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D007249:Inflammation / Q000097:blood*; D007958:Leukocyte Count / Q000379:methods; D008297:Male; D063847:Mean Platelet Volume / Q000379:methods; D008875:Middle Aged; D015995:Prevalence; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000453:epidemiology / Q000503:physiopathology; D012189:Retrospective Studies; D013223:Statistics as Topic; D014421:Turkey / Q000453:epidemiology; D014527:Uric Acid / Q000097:blood*
chemical_list: D015415:Biomarkers; D014527:Uric Acid; D002097:C-Reactive Protein
keywords: Dipping status; hypertension; mean platelet volume; neutrophil-to-lymphocyte ratio; platelet-to-lymphocyte ratio; serum uric acid