title: Schizotypy and auditory mismatch negativity in a non-clinical sample of young adults.
abstract: Schizophrenia may be conceptualised using a dimensional approach to examine trait-like expression such as schizotypy within non-clinical populations to better understand pathophysiology. A candidate psychosis-risk marker, the auditory mismatch negativity (MMN) is thought to index the functionality of glutamatergic NMDA receptor mediated neurotransmission. Although the MMN is robustly reduced in patients with schizophrenia, the association between MMN and schizotypy in the general population is under-investigated. Thirty-five healthy participants completed the Schizotypal Personality Questionnaire (SPQ) and a multi-feature MMN paradigm (standards 82%, 50ms, 1000Hz, 80dB) with duration (100ms), frequency (1200Hz) and intensity (90dB) deviants (6% each). Spearman's correlations were used to explore the association between schizotypal personality traits and MMN amplitude. Few associations were identified between schizotypal traits and MMN. Higher Suspiciousness subscale scores tended to be correlated with larger frequency MMN amplitude. A median-split comparison of the sample on Suspiciousness scores showed larger MMN (irrespective of deviant condition) in the High compared to the Low Suspiciousness group. The trend-level association between MMN and Suspiciousness is in contrast to the robustly attenuated MMN amplitude observed in schizophrenia. Reductions in MMN may reflect a schizophrenia-disease state, whereas non-clinical schizotypy may not be subserved by similar neuropathology.
authors.affiliation: School of Psychology, Centre for Health Initiatives and Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, Australia. Electronic address: sbroyd@uow.edu.au.
authors.forename: Samantha J
authors.initials: SJ
authors.lastname: Broyd
authors.affiliation: School of Psychology and Priority Research Centre for Translational Neuroscience and Mental Health University of Newcastle, Newcastle, NSW, Australia.
authors.forename: Patricia T
authors.initials: PT
authors.lastname: Michie
authors.affiliation: School of Psychiatry, University of New South Wales and Neuroscience Research Australia, Sydney, Australia.
authors.forename: Jason
authors.initials: J
authors.lastname: Bruggemann
authors.affiliation: School of Psychology, Centre for Health Initiatives and Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, Australia.
authors.forename: Hendrika H
authors.initials: HH
authors.lastname: van Hell
authors.affiliation: School of Psychology, Centre for Health Initiatives and Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, Australia.
authors.forename: Lisa-Marie
authors.initials: LM
authors.lastname: Greenwood
authors.affiliation: School of Psychology, Centre for Health Initiatives and Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, Australia.
authors.forename: Rodney J
authors.initials: RJ
authors.lastname: Croft
authors.affiliation: School of Psychology and Priority Research Centre for Translational Neuroscience and Mental Health University of Newcastle, Newcastle, NSW, Australia.
authors.forename: Juanita
authors.initials: J
authors.lastname: Todd
authors.affiliation: School of Psychiatry, University of New South Wales and Neuroscience Research Australia, Sydney, Australia.
authors.forename: Rhoshel
authors.initials: R
authors.lastname: Lenroot
authors.affiliation: School of Psychology, Centre for Health Initiatives and Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, Australia.
authors.forename: Nadia
authors.initials: N
authors.lastname: Solowij
mesh_terms: D000161:Acoustic Stimulation; D000293:Adolescent; D000328:Adult; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D011618:Psychotic Disorders / Q000503:physiopathology; D016194:Receptors, N-Methyl-D-Aspartate; D012559:Schizophrenia / Q000503:physiopathology*; D012569:Schizotypal Personality Disorder / Q000503:physiopathology*; D009435:Synaptic Transmission; D055815:Young Adult
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate
keywords: ERP; Event-related potential; MMN; Mismatch negativity; Schizophrenia; Schizotypy; Suspiciousness