title: Effect of weight loss on renal function in overweight and obese patients with heart failure.
abstract: OBJECTIVE
  The effect of intentional weight loss on glomerular filtration rate (GFR) in overweight and obese patients with heart failure (HF), diabetes mellitus (DM) and/or metabolic syndrome (MS) has not been studied. The purpose of the present study is to assess the short term effects of intentional weight loss on renal function in this population.
  
  
  METHODS
  Fifty nine patients were recruited to participate in a 3-month intensive behavioral weight management intervention and received one of two standard structured energy-restricted meal plans (1200 or 1500kcal/day) based on their computed calorie deficit. Weight and renal function (serum creatinine, BUN and estimated glomerular filtration rate based on two formulas - Modification in Renal Disease Study (MDRD), and modified version of Cockcroft-Gault formula reported by Salazar Corcoran for obese patients (absolute and relative formulas) - were evaluated at baseline and at 3 months.
  
  
  RESULTS
  Participants had eGFR in the normal range at baseline and lost an average of 7.56±14.9 pounds (p<0.0001) over 3 months; however, there was no significant reduction in serum creatinine, BUN or eGFR.
  
  
  CONCLUSIONS
  This study provides evidence that intentional weight loss in overweight and obese patients with HF along with DM, and/or MS and normal baseline renal function does not adversely affect renal function overtime.
authors.affiliation: Program in Nursing Science, University of California Irvine, Irvine, CA, United States. Electronic address: mmotie@uci.edu.
authors.forename: Marjan
authors.initials: M
authors.lastname: Motie
authors.affiliation: Program in Nursing Science, University of California Irvine, Irvine, CA, United States.
authors.forename: Lorraine S
authors.initials: LS
authors.lastname: Evangelista
authors.affiliation: Clinical Heart Failure Program, Department of Medicine, University of California Irvine Medical Center, Irvine, CA, United States.
authors.forename: Dawn
authors.initials: D
authors.lastname: Lombardo
authors.affiliation: Program in Nursing Science, University of California Irvine, Irvine, CA, United States.
authors.forename: Josiah
authors.initials: J
authors.lastname: Hoi
authors.affiliation: Cardiology University of California at Los Angeles, David Geffen School of Medicine, Los Angeles, CA, United States.
authors.forename: Tamara B
authors.initials: TB
authors.lastname: Horwich
authors.affiliation: Medicine/Cardiology UCLA, Heart Failure Program, Cedars-Sinai Heart Institute, Los Angeles, CA, United States.
authors.forename: Michele
authors.initials: M
authors.lastname: Hamilton
authors.affiliation: Ahmanson-UCLA Cardiomyopathy Center, Cardiology David Geffen School of Medicine, Los Angeles, CA, United States.
authors.forename: Gregg C
authors.initials: GC
authors.lastname: Fonarow
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001823:Body Composition; D048909:Diabetes Complications / Q000150:complications / Q000628:therapy; D005260:Female; D005919:Glomerular Filtration Rate; D006333:Heart Failure / Q000150:complications*; D006801:Humans; D007668:Kidney / Q000502:physiology*; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000628:therapy; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000628:therapy*; D055105:Waist Circumference; D015431:Weight Loss; D061217:Weight Reduction Programs
keywords: Heart failure; Hyperfiltration; Obesity; Renal function; Weight loss