title: Advances in Bone-targeted Drug Delivery Systems for Neoadjuvant Chemotherapy for Osteosarcoma.
abstract: Targeted therapy for osteosarcoma includes organ, cell and molecular biological targeting; of these, organ targeting is the most mature. Bone-targeted drug delivery systems are used to concentrate chemotherapeutic drugs in bone tissues, thus potentially resolving the problem of reaching the desired foci and minimizing the toxicity and adverse effects of neoadjuvant chemotherapy. Some progress has been made in bone-targeted drug delivery systems for treatment of osteosarcoma; however, most are still at an experimental stage and there is a long transitional period to clinical application. Therefore, determining how to combine new, polymolecular and multi-pathway targets is an important research aspect of designing new bone-targeted drug delivery systems in future studies. The purpose of this article was to review the status of research on targeted therapy for osteosarcoma and to summarize the progress made thus far in developing bone-targeted drug delivery systems for neoadjuvant chemotherapy for osteosarcoma with the aim of providing new ideas for highly effective therapeutic protocols with low toxicity for patients with osteosarcoma.
authors.affiliation: Department of Orthopaedics, School of Medicine, Jinling Hospital, Nanjing University, Nanjing, China.
authors.forename: Cheng-Jun
authors.initials: CJ
authors.lastname: Li
authors.affiliation: Department of Orthopaedics, School of Medicine, Jinling Hospital, Nanjing University, Nanjing, China.
authors.forename: Xiao-Zhou
authors.initials: XZ
authors.lastname: Liu
authors.affiliation: Department of Orthopaedics, School of Medicine, Jinling Hospital, Nanjing University, Nanjing, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Orthopaedics, School of Medicine, Jinling Hospital, Nanjing University, Nanjing, China.
authors.forename: Long-Bang
authors.initials: LB
authors.lastname: Chen
authors.affiliation: Department of Orthopaedics, School of Medicine, Jinling Hospital, Nanjing University, Nanjing, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Shi
authors.affiliation: Department of Orthopaedics, School of Medicine, Jinling Hospital, Nanjing University, Nanjing, China.
authors.forename: Su-Jia
authors.initials: SJ
authors.lastname: Wu
authors.affiliation: Department of Orthopaedics, School of Medicine, Jinling Hospital, Nanjing University, Nanjing, China.
authors.forename: Jian-Ning
authors.initials: JN
authors.lastname: Zhao
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001859:Bone Neoplasms / Q000188:drug therapy*; D016503:Drug Delivery Systems; D006801:Humans; D020360:Neoadjuvant Therapy; D012516:Osteosarcoma / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents
keywords: Cell-targeted therapy; Drug delivery system; Molecular biological targets; Organ-targeted therapy; Osteosarcoma