title: Common Mechanisms Underlying Epileptogenesis and the Comorbidities of Epilepsy.
abstract: The importance of comorbidities in determining the quality of life of individuals with epilepsy and their families has received increasing attention in the past decade. Along with it has come a recognition that in some individuals, certain comorbidities may have preexisted, and may have contributed to their developing epilepsy. Many mechanisms are capable of interconnecting different dysfunctions that manifest as distinct disorders, often diagnosed and managed by different specialists. We review the human data from the perspective of epidemiology as well as insights gathered from neurodiagnostic and endocrine studies. Animal studies are reviewed to refine our mechanistic understanding of the connections, because they permit the narrowing of variables, which is not possible when studying humans.
authors.affiliation: Department of Pediatrics, Division of Pediatric Neurology, David Geffen School of Medicine at UCLA, UCLA Medical Center, Los Angeles, California 90095-1752.
authors.forename: Andrey
authors.initials: A
authors.lastname: Mazarati
authors.affiliation: Department of Pediatrics, Division of Pediatric Neurology, David Geffen School of Medicine at UCLA, UCLA Medical Center, Los Angeles, California 90095-1752 Department of Neurology, David Geffen School of Medicine at UCLA, UCLA Medical Center, Los Angeles, California 90095-1752.
authors.forename: Raman
authors.initials: R
authors.lastname: Sankar
mesh_terms: D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging; D015897:Comorbidity; D003863:Depression / Q000150:complications*; D004827:Epilepsy / Q000453:epidemiology / Q000209:etiology*; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D007249:Inflammation / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D018377:Neurotransmitter Agents / Q000378:metabolism; D011788:Quality of Life; D012701:Serotonin / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D018377:Neurotransmitter Agents; D012701:Serotonin; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid