title: The influence of the body mass index (BMI) on selected parameters of the coagulation system in patients with disorders of the balance system taking oral contraceptives.
abstract: BACKGROUND
  The objective of the paper is to evaluate the influence of the body mass index (BMI) on selected parameters of the coagulation system in patients with disorders of the balance system taking oral contraceptives.
  
  
  METHODS
  105 young women participated in the study who were divided into 2 groups. Group I: 52 women disorders of the balance system taking hormonal contraceptives for at least 2 months, between the age of 20-49; Group II: 53 women with no disorders of the balance system taking hormonal contraceptives for at least 2 months, between the age of 18-40. Patients entering the study underwent full otoneurological examination, detailed laryngological assessment and the examination of selected parameters of the hemostasis system, including the evaluation of fibrinogen and D-dimer levels, APTT and PT, estradiol and progesterone concentrations in the blood serum and evaluation of the body mass index (BMI).
  
  
  RESULTS
  Central vertigo was the most common type of vertigo in the study group (59,6% of cases). Other vertigo types in this group included compensated vertigo of mixed origin (36,6% of cases) and peripheral vertigo (only 3,8% of cases), which indicates that 40.4% of the cases suffer from damage to the labyrinth. The analysis of the concentration of estradiol in the blood serum revealed, after consideration of a menstrual cycle phase, that estradiol concentration exceeded normative values significantly more often in the study group than in the control group and that estradiol concentration was significantly less frequently below the norm in the study group; the difference was statistically significant (p=0,048). The body mass index (BMI) of women participating in the study significantly correlated with the concentration of D-dimers only in the study group (p=0,35 vs p=0,012).
  
  
  CONCLUSIONS
  Evaluating the body mass index before administering hormonal contraception can be useful to eliminate other risk factors for thromboembolism. In order to prevent potential thromboembolism episodes, administering hormonal contraception only after lowering the body mass index may also be worth considering.
authors.affiliation: Medical University of Lodz.
authors.forename: Marzena
authors.initials: M
authors.lastname: Bielinska
authors.affiliation: Medical University of Lodz.
authors.forename: Joanna
authors.initials: J
authors.lastname: Urbaniak
authors.affiliation: Medical University of Lodz.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Kusmierczyk
authors.affiliation: Medical University of Lodz.
authors.forename: Jurek
authors.initials: J
authors.lastname: Olszewski
authors.affiliation: Medical University of Lodz.
authors.forename: Piotr
authors.initials: P
authors.lastname: Pietkiewicz
mesh_terms: D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D015992:Body Mass Index; D003267:Contraception / Q000379:methods; D003277:Contraceptives, Oral, Combined / Q000008:administration & dosage / Q000009:adverse effects*; D004967:Estrogens / Q000097:blood*; D005260:Female; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D055815:Young Adult
chemical_list: D003277:Contraceptives, Oral, Combined; D004967:Estrogens