title: Differential Roles for Dopamine D1-Like and D2-Like Receptors in Mediating the Reinforcing Effects of Cocaine: Convergent Evidence from Pharmacological and Genetic Studies.
abstract: A series of studies by Drs. Barak Caine, James Woods, Gregory Collins, Jonathan Katz and Takato Hiranita demonstrated a novel and unique reinforcing effect using dopamine (DA) D2-like receptor [D2-like R: D2, D3, and D4receptor subtypes (respectively, D2R, D3R, and D4R)] agonists in rats and genetically modified mice. In order to understand how important their findings are, a comparison was made regarding the reinforcing effects of DA D2-like R full agonists with those of DA uptake inhibitors and of a DA D1-like receptor [D1-like R, D1and D5receptor subtypes (D1R and D5R)] full agonist (±)-SKF 82958.
authors.affiliation: Division of Neurotoxicology, National Center for Toxicological Research (NCTR), U.S. Food and Drug Administration (FDA), 3900 NCTR Road Jefferson, AR 72079-9501, USA.
authors.forename: Takato
authors.initials: T
authors.lastname: Hiranita
authors.affiliation: Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr., Mail Code 7764, San Antonio, TX 78229, USA; South Texas Veterans Health Care System, 7400 Merton Minter Dr, San Antonio, TX 78229, USA.
authors.forename: Gregory T
authors.initials: GT
authors.lastname: Collins