title: Metal-Free [2+2+2] Cycloaddition of Ynamides and Nitriles: Mild and Regioselective Synthesis of Fully Substituted Pyridines.
abstract: A metal-free trimolecular [2+2+2] cycloaddition of internal ynamides and nitriles for de novo synthesis of fully substituted pyridines is disclosed. With the versatile Brønsted acid catalyst HNTf2 , the mild intermolecular cyclotrimerization process proceeds with complementary chemoselectivity and excellent regioselectivity.
authors.affiliation: Department of Chemistry, The Hong Kong University of Science and Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong SAR, China.|HKUST Shenzhen Research Institute, Shenzhen, 518057, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Lab of Computational Chemistry and Drug Design, Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, 518055, China.
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Song
authors.affiliation: Lab of Computational Chemistry and Drug Design, Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, 518055, China. zhangxh@pkusz.edu.cn.
authors.forename: Xinhao
authors.identifier: 0000-0002-8210-2531
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, The Hong Kong University of Science and Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong SAR, China. sunjw@ust.hk.|HKUST Shenzhen Research Institute, Shenzhen, 518057, China. sunjw@ust.hk.
authors.forename: Jianwei
authors.initials: J
authors.lastname: Sun
keywords: Brønsted acid; cycloaddition; cyclotrimerization; heterocycles; reaction mechanisms