title: Association of a SNP in SLC35F3 Gene with the Risk of Hypertension in a Chinese Han Population.
abstract: A recent study suggested that SLC35F3 which encoded a thiamine transporter was a new candidate gene for hypertension. The goal of this study was to investigate the association between the single-nucleotide polymorphisms (SNPs) in the SLC35F3 gene and hypertension in a Chinese population. Sanger sequencing was performed in 93 samples to find SNPs in coding regions and intron-exon boundaries in the SLC35F3 gene. We found eight genetic variants in the coding regions of SLC35F3 and subsequently genotyped a non-synonymous variant rs34032258 (C > G) in 1060 hypertension patients and 1467 controls. After adjusting for age and gender, multivariate analysis of covariance showed that the variant was associated with hypertensive traits. In detail, diastolic blood pressure (DBP) was 8 mmHg higher, blood urea nitrogen was 12 mmol/L higher, and creatinine was 15 mmol/L lower in G/G group compared with C/C group (p = 0.007; 0.012 and 0.029, respectively). Further study suggested that C/G+G/G had higher DBP than C/C genotype in those whose DBP ≥ 90 mmHg (98.02 mmHg vs. 94.04 mmHg, p = 0.021). No significant difference has been found in systolic blood pressure between different genotypes. Additionally, in the subgroup of obesity, allele distribution of this variant has shown significant difference between hypertensive patients and normotensive controls (p = 0.018). In conclusion, we found that the rs34032258 in the SLC35F3 gene was associated with high blood pressure and may increase the risk of hypertension. The new hypertension-susceptibility locus may involve in the pathogenesis of hypertension and indicate some novel treatment implications.
authors.affiliation: Shanghai Key Laboratory of Vascular Biology, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineShanghai, China; Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of MedicineShanghai, China; Laboratory of Vascular Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesShanghai, China; State Key Laboratory of Medical Genomics, Shanghai Jiao Tong UniversityShanghai, China.
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Zang
authors.affiliation: Shanghai Key Laboratory of Vascular Biology, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineShanghai, China; Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of MedicineShanghai, China; Laboratory of Vascular Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesShanghai, China; State Key Laboratory of Medical Genomics, Shanghai Jiao Tong UniversityShanghai, China.
authors.forename: Wei-Qing
authors.initials: WQ
authors.lastname: Han
authors.affiliation: Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Bio-X Institutes, Shanghai Jiao Tong University Shanghai, China.
authors.forename: Feng-Ping
authors.initials: FP
authors.lastname: Yang
authors.affiliation: Shanghai Key Laboratory of Vascular Biology, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineShanghai, China; Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of MedicineShanghai, China; Laboratory of Vascular Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesShanghai, China; State Key Laboratory of Medical Genomics, Shanghai Jiao Tong UniversityShanghai, China.
authors.forename: Kai-Da
authors.initials: KD
authors.lastname: Ji
authors.affiliation: Shanghai Key Laboratory of Vascular Biology, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineShanghai, China; Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of MedicineShanghai, China; Laboratory of Vascular Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesShanghai, China; State Key Laboratory of Medical Genomics, Shanghai Jiao Tong UniversityShanghai, China.
authors.forename: Ji-Guang
authors.initials: JG
authors.lastname: Wang
authors.affiliation: Shanghai Key Laboratory of Vascular Biology, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineShanghai, China; Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of MedicineShanghai, China; Laboratory of Vascular Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesShanghai, China; State Key Laboratory of Medical Genomics, Shanghai Jiao Tong UniversityShanghai, China.
authors.forename: Ping-Jin
authors.initials: PJ
authors.lastname: Gao
authors.affiliation: Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Bio-X Institutes, Shanghai Jiao Tong University Shanghai, China.
authors.forename: Guang
authors.initials: G
authors.lastname: He
authors.affiliation: Shanghai Key Laboratory of Vascular Biology, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineShanghai, China; Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of MedicineShanghai, China; Laboratory of Vascular Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesShanghai, China; State Key Laboratory of Medical Genomics, Shanghai Jiao Tong UniversityShanghai, China.
authors.forename: Sheng-Nan
authors.initials: SN
authors.lastname: Wu
keywords: SLC35F3; SNP; association; hypertension; susceptibility