title: No association between the rs10503253 polymorphism in the CSMD1 gene and schizophrenia in a Han Chinese population.
abstract: Schizophrenia (SCZ) is a complex, heritable, and devastating psychiatric disorder. Recent genome-wide association studies have identified a single-nucleotide polymorphism (SNP; rs10503253) in the CUB and SUSHI multiple domains 1 (CSMD1) gene as a risk factor for SCZ. In this study, we investigated whether the rs10503253 in CSMD1 contributes to the risk of SCZ in a Han Chinese population.
  
  
  
  We conducted a case-control study in a population from eastern China, involving 1378 SCZ patients and 1091 unrelated healthy controls, using the ligase detection reaction-polymerase chain reaction method to genotype the rs10503253 polymorphism in the CSMD1 gene.
  
  
  
  No significant association was found between the SCZ patients and controls for any allele or genotype frequency of the SNP rs10503253 (all P > 0.05).
  
  
  
  Our findings do not support an association between CSMD1 rs10503253 and SCZ in a Han Chinese population.
authors.affiliation: Department of Psychosomatic Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200092, China.
authors.forename: Yansong
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Wuxi Mental Health Center, Wuxi, 214151, Jiangsu Province, China.
authors.forename: Zaohuo
authors.initials: Z
authors.lastname: Cheng
authors.affiliation: Wuxi Mental Health Center, Wuxi, 214151, Jiangsu Province, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Wuxi Mental Health Center, Wuxi, 214151, Jiangsu Province, China.
authors.forename: Chunhui
authors.initials: C
authors.lastname: Jin
authors.affiliation: Wuxi Mental Health Center, Wuxi, 214151, Jiangsu Province, China.
authors.forename: Jianmin
authors.initials: J
authors.lastname: Yuan
authors.affiliation: Wuxi Mental Health Center, Wuxi, 214151, Jiangsu Province, China.
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Wang
authors.affiliation: Wuxi Mental Health Center, Wuxi, 214151, Jiangsu Province, China. zhangfq@njmu.edu.cn.
authors.forename: Fuquan
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Department of Psychosomatic Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200092, China. zhaoxd@tongji.edu.cn.
authors.forename: Xudong
authors.initials: X
authors.lastname: Zhao
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012307:Risk Factors; D012559:Schizophrenia / Q000235:genetics*; D025521:Tumor Suppressor Proteins
chemical_list: C477880:CSMD1 protein, human; D008565:Membrane Proteins; D025521:Tumor Suppressor Proteins
keywords: CSMD1; Schizophrenia; rs10503253