title: Transcription Termination: Variations on Common Themes.
abstract: Transcription initiates pervasively in all organisms, which challenges the notion that the information to be expressed is selected mainly based on mechanisms defining where and when transcription is started. Together with post-transcriptional events, termination of transcription is essential for sorting out the functional RNAs from a plethora of transcriptional products that seemingly have no use in the cell. But terminating transcription is not that easy, given the high robustness of the elongation process. We review here many of the strategies that prokaryotic and eukaryotic cells have adopted to dismantle the elongation complex in a timely and efficient manner. We highlight similarities and diversity, underlying the existence of common principles in a diverse set of functionally convergent solutions.
authors.affiliation: Institut Jacques Monod, CNRS, UMR 7592, Université Paris Diderot, Sorbonne Paris Cité, F-75205 Paris, France. Electronic address: odil.porrua@ijm.fr.
authors.forename: Odil
authors.initials: O
authors.lastname: Porrua
authors.affiliation: Centre de Biophysique Moléculaire CNRS, Rue Charles Sadron 45071 Orléans cedex 2, France; ITP Sciences Biologiques & Chimie du Vivant, Université d'Orléans, France. Electronic address: marc.boudvillain@cnrs-orleans.fr.
authors.forename: Marc
authors.initials: M
authors.lastname: Boudvillain
authors.affiliation: Institut Jacques Monod, CNRS, UMR 7592, Université Paris Diderot, Sorbonne Paris Cité, F-75205 Paris, France. Electronic address: domenico.libri@ijm.fr.
authors.forename: Domenico
authors.initials: D
authors.lastname: Libri
mesh_terms: D005057:Eukaryotic Cells; D006801:Humans; D011387:Prokaryotic Cells; D012313:RNA / Q000096:biosynthesis / Q000235:genetics*; D022661:RNA, Untranslated / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics; D061806:Transcription Termination, Genetic; D014158:Transcription, Genetic
chemical_list: D022661:RNA, Untranslated; D014157:Transcription Factors; D012313:RNA