title: A Wearable Goggle Navigation System for Dual-Mode Optical and Ultrasound Localization of Suspicious Lesions: Validation Studies Using Tissue-Simulating Phantoms and an Ex Vivo Human Breast Tissue Model.
abstract: Surgical resection remains the primary curative treatment for many early-stage cancers, including breast cancer. The development of intraoperative guidance systems for identifying all sites of disease and improving the likelihood of complete surgical resection is an area of active ongoing research, as this can lead to a decrease in the need of subsequent additional surgical procedures. We develop a wearable goggle navigation system for dual-mode optical and ultrasound imaging of suspicious lesions. The system consists of a light source module, a monochromatic CCD camera, an ultrasound system, a Google Glass, and a host computer. It is tested in tissue-simulating phantoms and an ex vivo human breast tissue model. Our experiments demonstrate that the surgical navigation system provides useful guidance for localization and core needle biopsy of simulated tumor within the tissue-simulating phantom, as well as a core needle biopsy and subsequent excision of Indocyanine Green (ICG)-fluorescing sentinel lymph nodes. Our experiments support the contention that this wearable goggle navigation system can be potentially very useful and fully integrated by the surgeon for optimizing many aspects of oncologic surgery. Further engineering optimization and additional in vivo clinical validation work is necessary before such a surgical navigation system can be fully realized in the everyday clinical setting.
authors.affiliation: School of Engineering Science, University of Science and Technology of China, Hefei, China.
authors.forename: Zeshu
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Surgery, Anhui Medical University, Hefei, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Pei
authors.affiliation: School of Engineering Science, University of Science and Technology of China, Hefei, China.|College of Engineering, The Ohio State University, Columbus, Ohio, United States of America.
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
authors.affiliation: School of Engineering Science, University of Science and Technology of China, Hefei, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Gan
authors.affiliation: School of Engineering Science, University of Science and Technology of China, Hefei, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Ye
authors.affiliation: Department of Surgery, Anhui Medical University, Hefei, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Yue
authors.affiliation: Department of Surgery, Anhui Medical University, Hefei, China.
authors.forename: Benzhong
authors.initials: B
authors.lastname: Wang
authors.affiliation: Division of Surgical Oncology, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America.
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Povoski
authors.affiliation: Division of Surgical Oncology, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America.
authors.forename: Edward W
authors.initials: EW
authors.lastname: Martin
authors.affiliation: Pathology Department, College of Medicine, The Ohio State University, Columbus, Ohio, United States of America.
authors.forename: Charles L
authors.initials: CL
authors.lastname: Hitchcock
authors.affiliation: College of Engineering, The Ohio State University, Columbus, Ohio, United States of America.
authors.forename: Alper
authors.initials: A
authors.lastname: Yilmaz
authors.affiliation: Radiology Department, Wright Center for Innovation, College of Medicine, The Ohio State University, Columbus, Ohio, United States of America.
authors.forename: Michael F
authors.initials: MF
authors.lastname: Tweedle
authors.affiliation: School of Engineering Science, University of Science and Technology of China, Hefei, China.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Shao
authors.affiliation: School of Engineering Science, University of Science and Technology of China, Hefei, China.|College of Engineering, The Ohio State University, Columbus, Ohio, United States of America.
authors.forename: Ronald X
authors.initials: RX
authors.lastname: Xu
mesh_terms: D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D003201:Computers; D004867:Equipment Design; D005139:Eyeglasses; D006801:Humans; D007909:Lenses; D061848:Optical Imaging / Q000295:instrumentation*; D019047:Phantoms, Imaging; D021701:Sentinel Lymph Node Biopsy; D014463:Ultrasonography / Q000295:instrumentation*