title: Effect of NO Synthase Blockade on Myocardial Contractility of Hypokinetic Rats during Stimulation of β-Adrenoreceptors.
abstract: Stimulation of β-adrenoreceptors with low (10(-8) and 10(-7) M) or high (10(-6) M) doses of isoproterenol in hypokinetic rats treated with L-NAME (a non-selective blocker of NO synthases) decreased or increased myocardial contractility, respectively. In control rats, all examined doses of isoproterenol used under blockade of NO synthases inhibited myocardial contractility.
authors.affiliation: Department of Anatomy, Physiology, and Human Health Protection, Kazan Federal University, Kazan, Tatarstan, Russia.
authors.forename: R I
authors.initials: RI
authors.lastname: Zaripova
authors.affiliation: Department of Anatomy, Physiology, and Human Health Protection, Kazan Federal University, Kazan, Tatarstan, Russia.
authors.forename: N I
authors.initials: NI
authors.lastname: Ziyatdinova
authors.affiliation: Department of Anatomy, Physiology, and Human Health Protection, Kazan Federal University, Kazan, Tatarstan, Russia. zefirovtl@mail.ru.
authors.forename: T L
authors.initials: TL
authors.lastname: Zefirov
mesh_terms: D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D003864:Depression, Chemical; D006352:Heart Ventricles / Q000187:drug effects; D007103:Immobilization; D007545:Isoproterenol / Q000494:pharmacology*; D009043:Motor Activity; D009200:Myocardial Contraction / Q000187:drug effects*; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology*; D009569:Nitric Oxide / Q000502:physiology; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000378:metabolism; D013268:Stimulation, Chemical; D016276:Ventricular Function
chemical_list: D000318:Adrenergic beta-Agonists; D011943:Receptors, Adrenergic, beta; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D007545:Isoproterenol; D019331:NG-Nitroarginine Methyl Ester
keywords: hypokinesia; isoproterenol; myocardial contractility; nitric oxide; rat