title: Co-morbidity of personality disorder in schizophrenia among psychiatric outpatients in China: data from epidemiologic survey in a clinical population.
abstract: The reported rates of personality disorder (PD) in subjects with schizophrenia (SZ) are quite varied across different countries, and less is known about the heterogeneity of PD among subjects with SZ. We examined the co-morbidity of PD among patients who are in the stable phase of SZ.
  
  
  
  850 subjects were randomly sampled from patients diagnosed with SZ in psychiatric and psycho-counseling clinics at Shanghai Mental Health Center. Co-morbidity of PDs was assessed through preliminary screening and patients were administered several modules of the SCID-II. Evidence of heterogeneity was evaluated by comparing patients diagnosed with SZ with those who presented with either affective disorder or neurosis (ADN).
  
  
  
  204 outpatients (24.0 %) in the stable phase of SZ met criteria for at least one type of DSM-IV PD. There was a higher prevalence of Cluster-A (odd and eccentric PD) and C (anxious and panic PD) PDs in SZ (around 12.0 %). The most prevalent PD was the paranoid subtype (7.65 %). Subjects with SZ were significantly more likely to have schizotypal PD (4.4 % vs. 2.1 %, p = 0.003) and paranoid PD (7.6 % vs. 5.4 %, p = 0.034), but much less likely to have borderline, obsessive-compulsive, depressive, narcissistic and histrionic PD.
  
  
  
  These findings suggest that DSM-IV PD is common in patients with SZ than in the general population. Patterns of co-morbidity with PDs in SZ are different from ADN.
authors.affiliation: Department of Medical Psychology, Faculty of Mental Health, Second Military Medical University, Shanghai, 200433, People's Republic of China.|Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 600 South Wanping Road, Shanghai, 200030, People's Republic of China.
authors.forename: YanYan
authors.initials: Y
authors.lastname: Wei
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 600 South Wanping Road, Shanghai, 200030, People's Republic of China.
authors.forename: TianHong
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Department of Psychological Medicine, Changi General Hospital, Singapore, Singapore.
authors.forename: Annabelle
authors.initials: A
authors.lastname: Chow
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 600 South Wanping Road, Shanghai, 200030, People's Republic of China.
authors.forename: YingYing
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 600 South Wanping Road, Shanghai, 200030, People's Republic of China.
authors.forename: LiHua
authors.initials: L
authors.lastname: Xu
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 600 South Wanping Road, Shanghai, 200030, People's Republic of China.
authors.forename: YunFei
authors.initials: Y
authors.lastname: Dai
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 600 South Wanping Road, Shanghai, 200030, People's Republic of China.
authors.forename: XiaoHua
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Medical Psychology, Faculty of Mental Health, Second Military Medical University, Shanghai, 200433, People's Republic of China.
authors.forename: Tong
authors.initials: T
authors.lastname: Su
authors.affiliation: Department of Medical Psychology, Faculty of Mental Health, Second Military Medical University, Shanghai, 200433, People's Republic of China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Pan
authors.affiliation: Department of Medical Psychology, Faculty of Mental Health, Second Military Medical University, Shanghai, 200433, People's Republic of China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Cui
authors.affiliation: Department of Medical Psychology, Faculty of Mental Health, Second Military Medical University, Shanghai, 200433, People's Republic of China.
authors.forename: ZiQiang
authors.initials: Z
authors.lastname: Li
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 600 South Wanping Road, Shanghai, 200030, People's Republic of China.
authors.forename: KaiDa
authors.initials: K
authors.lastname: Jiang
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 600 South Wanping Road, Shanghai, 200030, People's Republic of China.
authors.forename: ZePing
authors.initials: Z
authors.lastname: Xiao
authors.affiliation: Department of Medical Psychology, Faculty of Mental Health, Second Military Medical University, Shanghai, 200433, People's Republic of China. tangyun7633@sina.com.
authors.forename: YunXiang
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, 600 South Wanping Road, Shanghai, 200030, People's Republic of China. jijunwang27@163.com.|Shanghai Key Laboratory of Psychotic Disorders (No.13dz2260500), Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai, People's Republic of China. jijunwang27@163.com.
authors.forename: JiJun
authors.initials: J
authors.lastname: Wang
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D015897:Comorbidity; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006306:Health Surveys; D006801:Humans; D008297:Male; D008875:Middle Aged; D010045:Outpatients / Q000523:psychology*; D010554:Personality Disorders / Q000453:epidemiology* / Q000523:psychology; D015995:Prevalence; D012559:Schizophrenia / Q000453:epidemiology*; D012565:Schizophrenic Psychology
keywords: Clinical population; Cluster-A personality disorders; Prevalence; Psychosis; Schizotypal personality disorder