title: Hybrid anisotropic nanostructures for dual-modal cancer imaging and image-guided chemo-thermo therapies.
abstract: The multimodality theranostic system, which can integrate two or more different therapeutic modalities and multimodal imaging agents into a nanoentity, shows great promising prospects for the cancer treatment. Herein, we developed an efficient and novel strategy to synthesize hybrid anisotropic nanoparticles (HANs) with intrinsic multimodal theranostic capability [chemotherapy, photothermal therapy, magnetic resonance imaging (MRI), and photoacoustic imaging (PAI)]. For the first time, under the guidance of MRI and PAI, the chemotherapy and thermotherapy induced by administration of multifunctional hybrid nanoprobes were applied simultaneously to the treatment of colon cancer-bearing mice in vivo.
authors.affiliation: Department of Radiology of the First Hospital of Shanxi Medical University, Molecular Imaging Precision Medical Collaborative Innovation Center, Shanxi Medical University, Taiyuan, Shanxi 030001, China; Molecular Imaging Program at Stanford (MIPS), Canary Center at Stanford for Cancer Early Detection, Department of Radiology and Bio-X Program, School of Medicine, Stanford University, 1201 Welch Road, Lucas P095, Stanford, CA 94305-5484, USA.
authors.forename: Ruiping
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Molecular Imaging Program at Stanford (MIPS), Canary Center at Stanford for Cancer Early Detection, Department of Radiology and Bio-X Program, School of Medicine, Stanford University, 1201 Welch Road, Lucas P095, Stanford, CA 94305-5484, USA.
authors.forename: Kai
authors.initials: K
authors.lastname: Cheng
authors.affiliation: Department of Chemistry, Stanford University, CA 94305, USA.
authors.forename: Alexander L
authors.initials: AL
authors.lastname: Antaris
authors.affiliation: Molecular Imaging Program at Stanford (MIPS), Canary Center at Stanford for Cancer Early Detection, Department of Radiology and Bio-X Program, School of Medicine, Stanford University, 1201 Welch Road, Lucas P095, Stanford, CA 94305-5484, USA.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Ma
authors.affiliation: Molecular Imaging Program at Stanford (MIPS), Canary Center at Stanford for Cancer Early Detection, Department of Radiology and Bio-X Program, School of Medicine, Stanford University, 1201 Welch Road, Lucas P095, Stanford, CA 94305-5484, USA.
authors.forename: Min
authors.initials: M
authors.lastname: Yang
authors.affiliation: Molecular Imaging Program at Stanford (MIPS), Canary Center at Stanford for Cancer Early Detection, Department of Radiology and Bio-X Program, School of Medicine, Stanford University, 1201 Welch Road, Lucas P095, Stanford, CA 94305-5484, USA.
authors.forename: Sindhuja
authors.initials: S
authors.lastname: Ramakrishnan
authors.affiliation: Molecular Imaging Program at Stanford (MIPS), Canary Center at Stanford for Cancer Early Detection, Department of Radiology and Bio-X Program, School of Medicine, Stanford University, 1201 Welch Road, Lucas P095, Stanford, CA 94305-5484, USA.
authors.forename: Guifeng
authors.initials: G
authors.lastname: Liu
authors.affiliation: Molecular Imaging Program at Stanford (MIPS), Canary Center at Stanford for Cancer Early Detection, Department of Radiology and Bio-X Program, School of Medicine, Stanford University, 1201 Welch Road, Lucas P095, Stanford, CA 94305-5484, USA.
authors.forename: Alex
authors.initials: A
authors.lastname: Lu
authors.affiliation: Department of Chemistry, Stanford University, CA 94305, USA.
authors.forename: Hongjie
authors.initials: H
authors.lastname: Dai
authors.affiliation: Department of Nuclear Medicine and PET Center, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China. Electronic address: meitian@zju.edu.cn.
authors.forename: Mei
authors.initials: M
authors.lastname: Tian
authors.affiliation: Molecular Imaging Program at Stanford (MIPS), Canary Center at Stanford for Cancer Early Detection, Department of Radiology and Bio-X Program, School of Medicine, Stanford University, 1201 Welch Road, Lucas P095, Stanford, CA 94305-5484, USA. Electronic address: zcheng@stanford.edu.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Cheng
mesh_terms: D000818:Animals; D016880:Anisotropy; D045744:Cell Line, Tumor; D003110:Colonic Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy*; D003131:Combined Modality Therapy / Q000379:methods; D003287:Contrast Media / Q000737:chemistry; D004358:Drug Therapy / Q000379:methods; D005260:Female; D019073:HT29 Cells; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D008819:Mice, Nude; D064847:Multimodal Imaging / Q000379:methods; D053758:Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use*; D061088:Photoacoustic Techniques / Q000379:methods*; D000068936:Theranostic Nanomedicine / Q000379:methods; D016896:Treatment Outcome
chemical_list: D003287:Contrast Media
keywords: Chemotherapy; Hybrid anisotropic NanoStructures; Magnetic resonance imaging; Photoacoustic imaging; Photothermal therapy