title: Late-onset granulomatous prostatitis following intravesical bacille Calmette-Guerin therapy: case report.
abstract: Bacille Calmette-Guerin intravesical treatment is the most effective treatment for reducing the recurrence of non-muscle-invasive urothelial carcinomas. This treatment can sometimes have side effects and serious complications. Granulomatous prostatitis is a common histological finding but it rarely has a clinical presentation. We report a case of a 75-year-old, type 2 diabetic, male patient who was diagnosed with urothelial in situ carcinoma, for which he began treatment with Bacille Calmette-Guerin instillations. Five years later the patient presented nocturia, pollakiuria, severe urgency, and intense and recurrent perineal pain associated with marked elevation of prostatic specific antigen. A prostatic biopsy was performed that showed a moderate to severe granulomatous prostatitis related to bacille Calmette-Guerin. The patient received full antituberculosis combination drugs with a favorable clinical response.
authors.affiliation: Jefe de Urología, Director Centro de Cirugía Robótica, Clínica INDISA, Santiago, Chile; Facultad de Medicina, Universidad Andrés Bello, Santiago, Chile. Address: Avenida Santa María 1810, Santiago, Chile. Email: dr.octaviocastillo@gmail.com.
authors.forename: Octavio
authors.initials: O
authors.lastname: Castillo Cádiz
authors.affiliation: Departamento de Urología, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, España.
authors.forename: Lorena
authors.initials: L
authors.lastname: Villasenín Parrado
authors.affiliation: Servicio de Urología, Hospital Barros Luco-Trudeau, Santiago, Chile.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Borgna Christie
authors.affiliation: Departamento Anatomía Patología, Hospital Clínico Universidad de Chile, Santiago, Chile.
authors.forename: Iván
authors.initials: I
authors.lastname: Gallegos Méndez
authors.affiliation: Departamento Anatomía Patológica Clínica Santa María, Santiago, Chile.
authors.forename: Virginia
authors.initials: V
authors.lastname: Martínez Corta
mesh_terms: D000283:Administration, Intravesical; D000368:Aged; D001500:BCG Vaccine / Q000008:administration & dosage / Q000009:adverse effects*; D001706:Biopsy; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy; D006099:Granuloma / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D008297:Male; D011472:Prostatitis / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy
chemical_list: D001500:BCG Vaccine
keywords: BCG; active immunotherapy; granulomatous prostatitis; intravesical BCG immunotherapy