title: Canine antibody response to Lutzomyia longipalpis saliva in endemic area of visceral leishmaniasis.
abstract: BACKGROUND
  Canine exposure to Lutzomyia longipalpis bites and the potential of Leishmania infantum transmissibility for the vector were evaluated.
  
  
  METHODS
  Immunoglobulin G (IgG) anti-Lu longipalpis saliva and -L. infantum, and blood parasite load were determined in dogs from endemic areas of visceral leishmaniasis.
  
  
  RESULTS
  Blood parasitism was similar between symptomatic and asymptomatic dogs. IgG anti-L. infantum was higher in symptomatic dogs, but IgG anti-Lu. longipalpis saliva was mostly observed in higher titers in asymptomatic dogs, indicating vector preference for feeding on asymptomatic dogs.
  
  
  CONCLUSIONS
  Our data suggest a pivotal role of asymptomatic dogs in L. infantum transmission in endemic areas.
authors.affiliation: Laboratório de Patologia de Moléstias Infecciosas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, São Paulo, Brasil.|Departamento de Patologia, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, São Paulo, Brasil.
authors.forename: Luís Fábio da Silva
authors.initials: LF
authors.lastname: Batista
authors.affiliation: Laboratório de Patologia de Moléstias Infecciosas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, São Paulo, Brasil.
authors.forename: Vânia Lúcia Ribeiro da
authors.initials: VL
authors.lastname: Matta
authors.affiliation: Laboratório de Patologia de Moléstias Infecciosas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, São Paulo, Brasil.
authors.forename: Thaise Yumie
authors.initials: TY
authors.lastname: Tomokane
authors.affiliation: Departamento de Clínica, Cirurgia e Reprodução Animal, Faculdade de Medicina Veterinária, Universidade Estadual de São Paulo, Araçatuba, São Paulo, Brasil.
authors.forename: Acácio Duarte
authors.initials: AD
authors.lastname: Pacheco
authors.affiliation: Instituto Evandro Chagas, Ministério da Saúde, Ananindeua, Pará, Brasil.|Núcleo de Medicina Tropical, Universidade Federal do Pará, Belém, Pará, Brasil.
authors.forename: Fernando Tobias
authors.initials: FT
authors.lastname: Silveira
authors.affiliation: Instituto de Ciências da Saúde, Universidade Paulista, Campinas, São Paulo, Brasil.
authors.forename: Claudio Nazaretian
authors.initials: CN
authors.lastname: Rossi
authors.affiliation: Departamento de Clínica, Cirurgia e Reprodução Animal, Faculdade de Medicina Veterinária, Universidade Estadual de São Paulo, Araçatuba, São Paulo, Brasil.
authors.forename: Mary
authors.initials: M
authors.lastname: Marcondes
authors.affiliation: Laboratório de Patologia de Moléstias Infecciosas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, São Paulo, Brasil.
authors.forename: Márcia Dalastra
authors.initials: MD
authors.lastname: Laurenti
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood*; D001938:Brazil / Q000453:epidemiology; D004283:Dog Diseases / Q000175:diagnosis* / Q000453:epidemiology / Q000635:transmission; D004285:Dogs; D005260:Female; D007074:Immunoglobulin G / Q000097:blood*; D018314:Leishmania infantum / Q000276:immunology*; D007898:Leishmaniasis, Visceral / Q000175:diagnosis / Q000453:epidemiology / Q000635:transmission / Q000662:veterinary*; D000072138:Mosquito Vectors / Q000469:parasitology*; D059208:Parasite Load; D011576:Psychodidae / Q000469:parasitology*; D012463:Saliva / Q000737:chemistry; D014505:Urban Population
chemical_list: D000913:Antibodies, Protozoan; D007074:Immunoglobulin G