title: Thermal stability and decompositions kinetics under non-isothermal conditions of imatinib mesylate α form.
abstract: The thermal decomposition and kinetic parameters of synthetized imatinib mesylate α form α form were determined by thermogravimetry (TGA/DTG) under non-isothermal conditions. The experiments were performed at a 25-940°C temperature range at five different heating rates: 2.5Kmin(-1), 5Kmin(-1), 10Kmin(-1), 15Kmin(-1) and 20Kmin(-1) per minute in a nitrogen atmosphere. Imatinib mesylate α form presents one-step mass loss during the degradation process. The thermal stability of the examined material, the melting temperature (Tonset=220.6°C) and ΔH fusion=-95.74Jg(-1) at a heating rate of 10°Cmin(-1) was established. The values of activation energies have been estimated using Kissinger, Flynn-Wall-Ozawa (FWO) and Kissinger-Akahira-Sunose (KAS) methods.
authors.affiliation: Department of Analytical Chemistry, Wroclaw Medical University, Borowska 211 A, 50-556 Wroclaw, Poland. Electronic address: igor.mucha@umed.wroc.pl.
authors.forename: Igor
authors.initials: I
authors.lastname: Mucha
authors.affiliation: Department of Drug Form Technology, Wroclaw Medical University, Borowska 211 A, 50-556 Wroclaw, Poland.
authors.forename: Przemysław
authors.initials: P
authors.lastname: Baranowski
authors.affiliation: Department of Drug Form Technology, Wroclaw Medical University, Borowska 211 A, 50-556 Wroclaw, Poland.
authors.forename: Artur
authors.initials: A
authors.lastname: Owczarek
authors.affiliation: Department of Drug Form Technology, Wroclaw Medical University, Borowska 211 A, 50-556 Wroclaw, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Gajda
authors.affiliation: Department of Drug Form Technology, Wroclaw Medical University, Borowska 211 A, 50-556 Wroclaw, Poland.
authors.forename: Janusz
authors.initials: J
authors.lastname: Pluta
authors.affiliation: Laboratory of Elemental Analysis and Structural Research, Wroclaw Medical University, Borowska 211 A, 50-556 Wroclaw, Poland.
authors.forename: Agata
authors.initials: A
authors.lastname: Górniak
authors.affiliation: Silesian Catalysts Sp. z o. o., Duńska 9, 54-427 Wroclaw, Poland.
authors.forename: Paweł
authors.initials: P
authors.lastname: Niklewicz
authors.affiliation: Department of Drug Form Technology, Wroclaw Medical University, Borowska 211 A, 50-556 Wroclaw, Poland.
authors.forename: Bożena
authors.initials: B
authors.lastname: Karolewicz
mesh_terms: D004339:Drug Compounding; D004355:Drug Stability; D006358:Hot Temperature / Q000009:adverse effects; D000068877:Imatinib Mesylate / Q000737:chemistry* / Q000493:pharmacokinetics*; D007700:Kinetics; D013696:Temperature; D013818:Thermogravimetry / Q000379:methods; D014961:X-Ray Diffraction / Q000379:methods
chemical_list: D000068877:Imatinib Mesylate
keywords: DSC; Imatinib mesylate &alpha; TGA/DTG; activation energy; form; non-isothermal