title: Monitoring of adenovirus (ADV)-specific T cells in a boy with ADV pneumonia and disseminated disease after lung transplantation.
abstract: Human adenovirus (ADV) infections are the cause of severe morbidity and mortality in transplant recipients. Cidofovir (CDV) is the current standard antiviral treatment. We report the case of a 3-year-old boy after lung transplantation with severe ADV sepsis, who was monitored for ADV-specific T cells during his disease and recovery. A strong increase in ADV-specific T cells was accompanied by resolution of ADV in blood and bronchoalveolar lavage fluid. Antiviral treatment with CDV was individually adapted according to anti-ADV immune responses, which provides a new method for tailoring antiviral treatment in lung transplant recipients.
authors.affiliation: Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.|Integrated Research and Treatment Center Transplantation (IFB-Tx), Hannover Medical School, Hannover, Germany.
authors.forename: R E
authors.initials: RE
authors.lastname: Schultze-Florey
authors.affiliation: Integrated Research and Treatment Center Transplantation (IFB-Tx), Hannover Medical School, Hannover, Germany.|Institute for Transfusion Medicine, Hannover Medical School, Hannover, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Tischer
authors.affiliation: Pediatric Pneumology and Neonatology, Hannover Medical School, Hannover, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Schwerk
authors.affiliation: Institute of Virology, Hannover Medical School, Hannover, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Heim
authors.affiliation: Integrated Research and Treatment Center Transplantation (IFB-Tx), Hannover Medical School, Hannover, Germany.|Institute for Transfusion Medicine, Hannover Medical School, Hannover, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Eiz-Vesper
authors.affiliation: Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany. maecker.britta@mh-hannover.de.|Integrated Research and Treatment Center Transplantation (IFB-Tx), Hannover Medical School, Hannover, Germany. maecker.britta@mh-hannover.de.
authors.forename: B
authors.initials: B
authors.lastname: Maecker-Kolhoff
mesh_terms: D000256:Adenoviridae / Q000302:isolation & purification*; D000258:Adenovirus Infections, Human / Q000175:diagnosis / Q000188:drug therapy* / Q000821:virology; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001992:Bronchoalveolar Lavage Fluid / Q000821:virology; D002675:Child, Preschool; D000077404:Cidofovir; D003596:Cytosine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D058501:Enzyme-Linked Immunospot Assay; D005240:Feasibility Studies; D005434:Flow Cytometry; D006801:Humans; D016867:Immunocompromised Host; D007165:Immunosuppression Therapy / Q000009:adverse effects; D016040:Lung Transplantation / Q000009:adverse effects*; D008297:Male; D008991:Monitoring, Physiologic / Q000379:methods*; D063065:Organophosphonates / Q000008:administration & dosage / Q000627:therapeutic use*; D011024:Pneumonia, Viral / Q000175:diagnosis / Q000188:drug therapy* / Q000821:virology; D060888:Real-Time Polymerase Chain Reaction; D013601:T-Lymphocytes / Q000276:immunology / Q000821:virology*; D019562:Viral Load
chemical_list: D000998:Antiviral Agents; D063065:Organophosphonates; D003596:Cytosine; D000077404:Cidofovir
keywords: 
  ADV
  ; ADV-specific T cells; adenovirus; lung transplantation; monitoring; pediatric