title: The prognostic significance of surface dipeptidylpeptidase IV (CD26) expression in B-cell chronic lymphocytic leukemia.
abstract: A number of factors related to B-cell chronic lymphocytic leukemia (B-CLL) patients' prognosis have been identified. However, still some factors better reflecting disease activity in individual cases are explored. The study aimed to evaluate prognostic significance of dipeptidylpeptidase IV/CD26 expression on B-CLL cells and its relationship with other well established prognostic factors. The study included 94 patients with newly diagnosed B-CLL and involved analysis of clinical, laboratory, flow-cytometry and cytogenetic data. Detailed analysis showed that CD26 expression on B-CLL cells correlates with Rai's clinical stage of the disease at diagnosis (p=0.034), β2-microglobulin concentration (p=0.012), lactic acid dehydrogenase activity (p=0.045) and absolute lymphocytes' count (p=0.027) in the blood. The multivariate analysis revealed that time to treatment (TTT) was significantly influenced by Rai clinical stage, LDH activity in blood and CD26 expression on B-CLL cell's. Moreover, in the multivariate analysis restricted to the group of patients with documented cytogenetic risk (n=36) CD26 expression, Rai clinical stage and cytogenetic profile remained their independent impact on TTT. The results of our study indicate that the CD26 expression should be incorporated in B-CLL patients risk assessment along with well known prognostic factors, since it seems to have a relationship with the tumor mass and influences TTT.
authors.affiliation: Department of Haematology and Stem Cell Transplantation, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Matuszak
authors.affiliation: Department of Haematology and Stem Cell Transplantation, Poznan University of Medical Sciences, Poznan, Poland. Electronic address: krzysztof.lewandowski@skpp.edu.pl.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Lewandowski
authors.affiliation: Department of Haematology and Stem Cell Transplantation, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Czyż
authors.affiliation: Department of Haematology and Stem Cell Transplantation, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Jolanta
authors.initials: J
authors.lastname: Kiernicka-Parulska
authors.affiliation: Department of Haematology and Stem Cell Transplantation, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Przybyłowicz-Chalecka
authors.affiliation: Department of Haematology and Stem Cell Transplantation, Poznan University of Medical Sciences, Poznan, Poland; Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Jarmuż-Szymczak
authors.affiliation: Department of Haematology and Stem Cell Transplantation, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Maria
authors.initials: M
authors.lastname: Lewandowska
authors.affiliation: Department of Haematology and Stem Cell Transplantation, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Mieczysław
authors.initials: M
authors.lastname: Komarnicki
mesh_terms: D000328:Adult; D000368:Aged; D001402:B-Lymphocytes / Q000201:enzymology / Q000473:pathology; D018819:Dipeptidyl Peptidase 4 / Q000032:analysis*; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D018570:Risk Assessment; D061665:Time-to-Treatment; D047368:Tumor Burden
chemical_list: C042807:DPP4 protein, human; D018819:Dipeptidyl Peptidase 4
keywords: B-cell chronic lymphocytic leukemia; Dipetydylpeptidase IV/CD26; Prognostic factors