title: Efficacy of reduced-fluence photodynamic therapy for central serous chorioretinopathy associated with combined serous retinal detachment and fovea-involving pigment epithelial detachment.
abstract: The purpose of the study was to evaluate the effect of reduced-fluence photodynamic therapy (RFPDT) for chronic central serous chorioretinopathy (CSC) associated with serous retinal detachment (SRD) and fovea-involving pigment epithelial detachment (PED). Ten eyes of ten patients with chronic CSC associated with combined SRD and PED involving the fovea were included. RFPDT was applied to the hyperfluorescent area identified at the mid-to-late phase of indocyanine green angiography, which indicated the area of leakage. We evaluated the changes in best-corrected visual acuity (BCVA) and optical coherence tomography at month 1 and final follow-up visit. The mean age of the participants was 47.4 ± 7 years. The mean follow-up duration was 6.3 ± 4 months. At month 3, the SRD had resolved completely in all ten eyes (100 %), and PED had resolved in seven eyes (70 %). The initial mean BCVA improved from 20/50 at baseline to 20/32 at the last visit (P > 0.05). The mean central retinal thickness was reduced from 534 ± 279 µm at baseline to 194 ± 46 µm at the last examination (P < 0.001). The mean subfoveal choroidal thickness decreased from 461 ± 57 at baseline to 369 ± 75 at the final visit (P < 0.001). Reduced-fluence PDT appears as an effective treatment for chronic CSC cases associated with SRD and fovea-involving PED.
authors.affiliation: Istanbul RETINA Institute, Hakkı Yeten Cad. Unimed Center No: 19/7 Fulya Şişli, Istanbul, 34349, Turkey.
authors.forename: Serra
authors.initials: S
authors.lastname: Arf
authors.affiliation: Istanbul RETINA Institute, Hakkı Yeten Cad. Unimed Center No: 19/7 Fulya Şişli, Istanbul, 34349, Turkey.
authors.forename: Mumin
authors.initials: M
authors.lastname: Hocaoglu
authors.affiliation: Istanbul RETINA Institute, Hakkı Yeten Cad. Unimed Center No: 19/7 Fulya Şişli, Istanbul, 34349, Turkey.
authors.forename: Isil
authors.initials: I
authors.lastname: Sayman Muslubas
authors.affiliation: Istanbul RETINA Institute, Hakkı Yeten Cad. Unimed Center No: 19/7 Fulya Şişli, Istanbul, 34349, Turkey. mkaracorlu@gmail.com.
authors.forename: Murat
authors.initials: M
authors.lastname: Karacorlu
mesh_terms: D000328:Adult; D056833:Central Serous Chorioretinopathy / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D002829:Choroid / Q000473:pathology; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005584:Fovea Centralis / Q000473:pathology; D005654:Fundus Oculi; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage; D011166:Porphyrins / Q000008:administration & dosage*; D012163:Retinal Detachment / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D055213:Retinal Pigment Epithelium / Q000473:pathology*; D012189:Retrospective Studies; D013997:Time Factors; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D000077362:Verteporfin; D014792:Visual Acuity
chemical_list: D017319:Photosensitizing Agents; D011166:Porphyrins; D000077362:Verteporfin
keywords: Central serous chorioretinopathy; Fovea-involving pigment epithelial detachment; Indocyanine green angiography; Optical coherence tomography; Reduced-fluence photodynamic therapy; Serous retinal detachment