title: A paediatric case of successful non-myeloablative bone marrow transplantation after azacitidine therapy for non-Down syndrome acute megakaryoblastic leukaemia with monosomy 7.
abstract: We report a patient with non-Down syndrome AML, also known as AMKL, with monosomy 7, who was also obese and had a hearing impairment and mental retardation. Non-myeloablative bone marrow transplantation was performed successfully after the patient received less aggressive azacitidine treatment, without the usual intensive induction chemotherapy regimen for AML.
authors.affiliation: Department of Paediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.
authors.forename: Yuhki
authors.initials: Y
authors.lastname: Koga
authors.affiliation: Department of Paediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.
authors.forename: Utako
authors.initials: U
authors.lastname: Oba
authors.affiliation: Department of Paediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.
authors.forename: Wakako
authors.initials: W
authors.lastname: Kato
authors.affiliation: Department of Paediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ono
authors.affiliation: Department of Paediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Nakashima
authors.affiliation: Department of Paediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Takada
mesh_terms: D000293:Adolescent; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D001374:Azacitidine / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation / Q000379:methods*; D002872:Chromosome Deletion; D002897:Chromosomes, Human, Pair 7; D003131:Combined Modality Therapy; D006801:Humans; D007947:Leukemia, Megakaryoblastic, Acute / Q000235:genetics / Q000628:therapy*; D008297:Male
chemical_list: D000964:Antimetabolites, Antineoplastic; D001374:Azacitidine
keywords: acute megakaryoblastic leukaemia; azacitidine; monosomy 7