title: Plasma fatty acids, oxylipins, and risk of myocardial infarction: the Singapore Chinese Health Study.
abstract: We aimed to examine the prospective association between plasma FAs, oxylipins, and risk of acute myocardial infarction (AMI) in a Singapore Chinese population. A nested case-control study with 744 incident AMI cases and 744 matched controls aged 47-83 years was conducted within the Singapore Chinese Health Study. Nineteen plasma FAs and 12 oxylipins were quantified using MS. These were grouped into 12 FA clusters and 5 oxylipin clusters using hierarchical clustering, and their associations with AMI risk were assessed. Long-chain n-3 FAs [odds ratio (OR) = 0.67 per SD increase, 95% confidence interval (CI): 0.53-0.84, P < 0.001] and stearic acid (OR = 0.65, 95% CI: 0.44-0.97, P = 0.03) were inversely associated with AMI risk, whereas arachidonic acid (AA) was positively associated with AMI risk (OR = 1.25, 95% CI: 1.03-1.52, P = 0.02) in the multivariable model with adjustment for other FAs. Further adjustment for oxylipins did not substantially change these associations. An inverse association was observed between AA-derived oxylipin, thromboxane (TX)B2, and AMI risk (OR = 0.81, 95% CI: 0.71-0.93, P = 0.003). Circulating long-chain n-3 FAs and stearic acid were associated with a lower and AA was associated with a higher AMI risk in this Chinese population. The association between the oxylipin TXB2 and AMI requires further research.
authors.affiliation: Saw Swee Hock School of Public Health National University of Singapore and National University Health System, Singapore NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore Departments of Psychological Medicine National University of Singapore and National University Health System, Singapore.
authors.forename: Ye
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Saw Swee Hock School of Public Health National University of Singapore and National University Health System, Singapore.
authors.forename: Hiromi W L
authors.initials: HW
authors.lastname: Koh
authors.affiliation: Saw Swee Hock School of Public Health National University of Singapore and National University Health System, Singapore.
authors.forename: Hyungwon
authors.initials: H
authors.lastname: Choi
authors.affiliation: Saw Swee Hock School of Public Health National University of Singapore and National University Health System, Singapore Duke-NUS Graduate Medical School Singapore, Singapore.
authors.forename: Woon-Puay
authors.initials: WP
authors.lastname: Koh
authors.affiliation: Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute and Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh PA.
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Yuan
authors.affiliation: Department of Nutrition, University of California Davis and US Department of Agriculture, Agricultural Research Sservice, Western Human Nutrition Research Center, Davis CA.
authors.forename: John W
authors.initials: JW
authors.lastname: Newman
authors.affiliation: Saw Swee Hock School of Public Health National University of Singapore and National University Health System, Singapore.
authors.forename: Jin
authors.initials: J
authors.lastname: Su
authors.affiliation: Saw Swee Hock School of Public Health National University of Singapore and National University Health System, Singapore.
authors.forename: Jinling
authors.initials: J
authors.lastname: Fang
authors.affiliation: Saw Swee Hock School of Public Health National University of Singapore and National University Health System, Singapore National University of Singapore Environmental Research Institute, National University of Singapore, Singapore.
authors.forename: Choon Nam
authors.initials: CN
authors.lastname: Ong
authors.affiliation: Saw Swee Hock School of Public Health National University of Singapore and National University Health System, Singapore Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA rob_martinus_van_dam@nuhs.edu.sg.
authors.forename: Rob M
authors.initials: RM
authors.lastname: van Dam
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016718:Arachidonic Acid / Q000097:blood*; D044466:Asian People; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000453:epidemiology / Q000473:pathology; D054883:Oxylipins / Q000097:blood*; D011446:Prospective Studies; D012307:Risk Factors; D012846:Singapore; D013229:Stearic Acids / Q000097:blood*
chemical_list: D054883:Oxylipins; D013229:Stearic Acids; D016718:Arachidonic Acid; C031183:stearic acid
keywords: diet and dietary lipids; eicosanoids; epidemiology; fatty acid/metabolism; heart; lipidomics; lipids; mass spectrometry; nutrition; oxidized lipids