title: Bladder Cancer Molecular Taxonomy: Summary from a Consensus Meeting.
abstract: The advent of Omics technologies has been key to the molecular subclassification of urothelial bladder cancer. Several groups have used different strategies to this aim, with partially overlapping findings. The meeting at the Spanish National Cancer Research Center-CNIO was held to discuss such classifications and reach consensus where appropriate. After updated presentations on the work performed by the teams attending the meeting, a consensus was reached regarding the existence of a group of Basal-Squamous-like tumors - designated BASQ - charaterized the high expression of KRT5/6 and KRT14 and low/undetectable expression of FOXA1 and GATA3. An additional tumor subgroup with urothelial differentiation features was recognized whose optimal molecular definition is required. For other subtypes described, more work is needed to determine how robust they are and how to best define them at the molecular level.
authors.affiliation: Scott Department of Urology, Dan L. Duncan Cancer Center, Baylor College of Medicine , Houston, TX, USA.
authors.forename: Seth P
authors.initials: SP
authors.lastname: Lerner
authors.affiliation: Department of Urology and Department of Cancer Biology, U.T. M.D. Anderson Cancer Center , Houston, TX, USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: McConkey
authors.affiliation: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapell Hill , Chapell Hill, NC, USA.
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Hoadley
authors.affiliation: Department of Molecular and Cellular Biology, Baylor College of Medicine, Program in Translational Biology and Molecular Medicine, Dan L. Duncan Cancer Center for Cell Gene & Therapy, Scott Departmentof Urology, Baylor College of Medicine , Houston, TX, USA.
authors.forename: Keith S
authors.initials: KS
authors.lastname: Chan
authors.affiliation: Department of Genetics, Department of Medicine, Lineberger ComprehensiveCancer Center, University of North Carolina at Chapell Hill , Chapell Hill, NC, USA.
authors.forename: William Y
authors.initials: WY
authors.lastname: Kim
authors.affiliation: CNRS, UMR 144, Oncologie Moléculaire, Institut Curie , Paris, France.
authors.forename: François
authors.initials: F
authors.lastname: Radvanyi
authors.affiliation: Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University , Lund, Sweden.
authors.forename: Mattias
authors.initials: M
authors.lastname: Höglund
authors.affiliation: Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre-CNIO, Madrid, Spain and Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra , Barcelona, Spain.
authors.forename: Francisco X
authors.initials: FX
authors.lastname: Real
keywords: Bladder cancer; genomics; molecular classification; taxonomy