title: Glucocorticoid therapy and ocular hypertension.
abstract: The projected number of people who will develop age-related macular degeneration in estimated at 2020 is 196 million and is expected to reach 288 million in 2040. Also, the number of people with Diabetic retinopathy will grow from 126.6 million in 2010 to 191.0 million by 2030. In addition, it is estimated that there are 2.3 million people suffering from uveitis worldwide. Because of the anti-inflammatory properties of glucocorticoids (GCs), they are often used topically and/or intravitreally to treat ocular inflammation conditions or edema associated with macular degeneration and diabetic retinopathy. Unfortunately, ocular GC therapy can lead to severe side effects. Serious and sometimes irreversible eye damage can occur as a result of the development of GC-induced ocular hypertension causing secondary open-angle glaucoma. According to the world health organization, glaucoma is the second leading cause of blindness in the world and it is estimated that 80 million will suffer from glaucoma by 2020. In the current review, mechanisms of GC-induced damage in ocular tissue, GC-resistance, and enhancing GC therapy will be discussed.
authors.affiliation: North Texas Eye Research Institute, UNT Health Science Center, Fort Worth, TX, USA. Electronic address: adnan.dibas@unthsc.edu.
authors.forename: Adnan
authors.initials: A
authors.lastname: Dibas
authors.affiliation: North Texas Eye Research Institute, UNT Health Science Center, Fort Worth, TX, USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Yorio
mesh_terms: D000375:Aging / Q000378:metabolism / Q000502:physiology; D000818:Animals; D005938:Glucocorticoids / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D009798:Ocular Hypertension / Q000139:chemically induced* / Q000378:metabolism / Q000503:physiopathology; D011965:Receptors, Glucocorticoid / Q000378:metabolism
chemical_list: D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid
keywords: Glaucoma; Glucocorticoids; Steroid receptors; Trabecular meshwork