title: Bactericidal effect of graphene oxide/Cu/Ag nanoderivatives against Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus and Methicillin-resistant Staphylococcus aureus.
abstract: A systematic analysis of antibacterial activity of individual nanoderivatives, e.g. GO nanosheets, Ag and Cu nanoparticles (NPs), as well as combinations of Cu-Ag NPs, and GO-Cu-Ag nanocomposites against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae and Methicillin-resistant Staphylococcus aureus (MRSA) was performed. Chemical properties of the GO, Cu and Ag NPs were determined employing X-ray photoelectron spectroscopy and X-Ray-excited Auger electron spectroscopy. Morphology of corresponding nanoderivatives was studied employing transmission electron microscopy and scanning electron microscopy. It was shown that combination of Cu and Ag NPs, as well as GO-Cu-Ag nanocomposite material possess enhanced antibacterial activity through a possible synergy between multiple toxicity mechanisms. MRSA showed highest resistance in all cases.
authors.affiliation: Faculty of Mechanical Engineering and Design, Kaunas University of Technology, Studentų St. 56, LT-51424 Kaunas, Lithuania. Electronic address: virginija.jankauskaite@ktu.lt.
authors.forename: V
authors.initials: V
authors.lastname: JankauskaitĿ
authors.affiliation: Faculty of Medicine, Lithuanian University of Health Science, Eivenių St. 2, LT-50009 Kaunas, Lithuania. Electronic address: astravitka@hotmail.com.
authors.forename: A
authors.initials: A
authors.lastname: VitkauskienĿ
authors.affiliation: Institute of Materials Science, Kaunas University of Technology, Baršausko St. 59, LT-51423 Kaunas, Lithuania. Electronic address: algirdas.lazauskas@ktu.edu.
authors.forename: A
authors.initials: A
authors.lastname: Lazauskas
authors.affiliation: Department of Chemical and Biomolecular Engineering, Lehigh University, B336 Iacocca Hall, 111 Research Drive, Bethlehem, PA 18015, USA. Electronic address: job314@lehigh.edu.
authors.forename: J
authors.initials: J
authors.lastname: Baltrusaitis
authors.affiliation: Institute of Materials Science, Kaunas University of Technology, Baršausko St. 59, LT-51423 Kaunas, Lithuania. Electronic address: igorpros@mail.ru.
authors.forename: I
authors.initials: I
authors.lastname: ProsyĿevas
authors.affiliation: Institute of Materials Science, Kaunas University of Technology, Baršausko St. 59, LT-51423 Kaunas, Lithuania; Department of Physics, Kaunas University of Technology, Studentu St. 50, LT51368 Kaunas, Lithuania. Electronic address: mindaugas.andrulevicius@ktu.lt.
authors.forename: M
authors.initials: M
authors.lastname: AndruleviĿius
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003300:Copper / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects* / Q000502:physiology; D006108:Graphite / Q000494:pharmacology; D006801:Humans; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000502:physiology; D053768:Metal Nanoparticles; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000502:physiology; D010087:Oxides / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000502:physiology; D012834:Silver / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000502:physiology
chemical_list: D000900:Anti-Bacterial Agents; D010087:Oxides; D012834:Silver; D006108:Graphite; D003300:Copper
keywords: Ag; Bactericidal effect; Cu; Graphene oxide; Morphology; Nanoparticles