title: Short Communication: Evaluation of antimicrobial activities of Harmine, Harmaline, Nicotine and their complexes.
abstract: Harmine, Harmaline, Nicotine and its various complexes synthesized have been characterized by physical, spectral and analytical methods and curtained for in-vitro antimicrobial activity against different bacterial and fungal species at two different concentrations i.e.100μ/100µl and 200μ/100µl dose level respectively. Analysis showed that Nicotine, Zinc-Nico, Cd-Nico, Hg-Nico, Ni-Nico, Cu-Nico, Co-Nico, Harmine, and Harmaline having conc. of 100ug/ 100ul had antibacterial activity on zero, 5, 4, 10, zero, 5, 7, zero, zero strain of bacteria having an average of zero (SD=0.0000), 15.2000 (SD=1.30384), 18.2500 (SD=3.30404), 20.2000 (SD=1.39841), zero (SD=0.0000), 14.6000 (SD=0.89443), 15.8571 (SD=1.34519), zero (SD=0.0000), zero (SD=0.0000) respectively. Zinc (II) chloride, Cadmium (II) Iodide, Mercury (II) chloride, Nickel (II) chloride, Copper (II) chloride, Cobalt (II) chloride, Mercury (II) chloride, Mercury (II) harmine, Mercury (II) harmaline at 100ug/100ul is valid for 7, 8, 9, 2, 7, 8, 9, 10, 8 strains of bacteria with an average of 7.1429 (SD=1.06904), 10.0000 (SD=5.01427), 14.8889 (SD=6.00925), 6.0000 (SD=0.0000), 8.5714 (SD=4.27618), 8.2500 (SD=0.88641), 14.8889 (SD=6.00925), 18.6000 (SD=2.45855), 18.5000 (SD=1.85164) respectively. The above given compounds at the conc. of 200 μ/100ul is valid for 10, 9, 10, 8, 8, 10, 10, 10, 10 strains of bacteria with an average of 8.1 (SD=1.66333), 11.7778 (SD=5.28625), 16.1000 (SD=6.36745), 6.5000 (SD=0.92582), 9.7500 (SD=4.43203), 9.9000 (SD=2.76687), 16.1000 (SD=6.36745), 22.0000 (SD=2.44949), 20.4000 (SD=2.75681) respectively. The above given compounds at conc. of 200 μ/100ul showed antibacterial action on 3, 8, 8, 10, 3, 9, 8, zero, 3 strains of bacteria with an average of 14(SD=0.000), 16.8750 (SD=1.35620), 18.2500 (SD=3.45378), 22.7000 (SD=1.82878), 14.3333 (SD=0.57735), 16.7778 (SD=1.71594), zero (SD=0.000), 12.0000 (SD=1.00000) respectively. Hence according to the average value of the zone of inhibition, maximum antibacterial activity at 100-200ug/100ul is of Hg-Nico and Mercury salt; Mercury (II) harmine having an average of 20.2000 (SD=1.39841)-22.7000 (SD=1.82878) and 18.6000 (SD=2.45855)-22.0000 (SD=2.44949). Minimum antibacterial activity at 100-200ug/100ul is Nicotine100, Nicotine-Nico100, Harmine 100,Harmaline 100, Harmine 200 having zero average (SD=0.000).
authors.affiliation: Department of Pharmacy, Peshawar, Pakistan.
authors.forename: Saad
authors.initials: S
authors.lastname: Salman
authors.affiliation: Islamia College University, Peshawar, Pakistan.
authors.forename: Fariha
authors.initials: F
authors.lastname: Idrees
authors.affiliation: Department of Pharmacy, Abdul Wali Khan, Mardan, Pakistan.
authors.forename: Sadia
authors.initials: S
authors.lastname: Pervaiz
authors.affiliation: Centre of Biotechnology and Microbiology, Peshawar, Pakistan.
authors.forename: Fahad Hassan
authors.initials: FH
authors.lastname: Shah
authors.affiliation: Islamia College University, Peshawar, Pakistan.
authors.forename: Sareer
authors.initials: S
authors.lastname: Badshah
authors.affiliation: Department of Pharmacy, Peshawar, Pakistan.
authors.lastname: Abdullah
authors.affiliation: Department of Pharmacy, Peshawar, Pakistan.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Usman
authors.affiliation: Department of Pharmacy, Peshawar, Pakistan.
authors.forename: Sm Ashhad
authors.initials: SA
authors.lastname: Halimi
authors.affiliation: Islamia College University, Peshawar, Pakistan.
authors.forename: Jawaria
authors.initials: J
authors.lastname: Idrees
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D006246:Harmaline / Q000494:pharmacology*; D006247:Harmine / Q000494:pharmacology*; D009538:Nicotine / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D006247:Harmine; D009538:Nicotine; D006246:Harmaline