title: Prognostic value of Sox2 expression in digestive tract cancers: A meta-analysis.
abstract: The aim of the present study was to accurately evaluate the association of Sox2 expression with the survival of patients with digestive tract cancers. Relevant literatures were identified by comprehensively searching databases including the Pubmed, Embase, CBMdisc, and Wanfang (up to October 2014). A meta-analysis was performed to clarify the association between Sox2 expression and overall survival or clinicopathological parameters of patients with digestive tract cancers (esophageal, gastric, and colorectal cancers). The results showed a significant association between high Sox2 expression and poor overall survival in patients with digestive tract carcinomas (HR=1.55, 95% CI=1.04-2.31), especially for patients with esophageal cancer (HR=2.04, 95%CI=1.30-3.22), colorectal cancer (HR=1.40, 95% CI=1.04-1.89), and digestive tract adenocarcinoma (HR=1.80, 95% CI=1.12-2.89), for Europeans (HR=1.98, 95% CI=1.44-2.71) or patients who did not receive neoadjuvant treatment (HR=1.73, 95% CI=1.10-2.72). Furthermore, Sox2 over-expression was highly correlated with vascular invasion (OR=1.86, 95% CI=1.25-2.77) and poor differentiation (OR=1.88, 95% CI=1.14-3.08), especially in esophageal and colorectal cancers. In conclusion, Sox2 expression may serve as a novel prognostic factor for patients with digestive tract cancers. Over-expression of Sox2 that is correlated with vascular invasion and poor differentiation suggests poor outcomes of patients with digestive tract cancers.
authors.affiliation: Department of Pathology & Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi, 832000, China.
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Du
authors.affiliation: Department of Pathology & Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi, 832000, China.
authors.forename: Liu-Hua
authors.initials: LH
authors.lastname: Wang
authors.affiliation: Department of Pathology & Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi, 832000, China.
authors.forename: Xiao-Wen
authors.initials: XW
authors.lastname: Chen
authors.affiliation: Department of Pathology & Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi, 832000, China.
authors.forename: Yi-Xiao
authors.initials: YX
authors.lastname: Li
authors.affiliation: Department of Pathology & Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi, 832000, China.
authors.forename: Yu-Cong
authors.initials: YC
authors.lastname: Li
authors.affiliation: Department of Pathology & Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi, 832000, China. cywwb2013@126.com.
authors.forename: Yu-Wen
authors.initials: YW
authors.lastname: Cao
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality / Q000473:pathology; D004938:Esophageal Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality / Q000473:pathology; D041981:Gastrointestinal Tract / Q000378:metabolism / Q000473:pathology; D015870:Gene Expression; D006801:Humans; D020360:Neoadjuvant Therapy / Q000379:methods; D060787:Neoplasm Grading; D009383:Neoplasms, Vascular Tissue / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality / Q000556:secondary; D011379:Prognosis; D055748:SOXB1 Transcription Factors / Q000235:genetics* / Q000378:metabolism; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality / Q000473:pathology; D016019:Survival Analysis
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; C527782:SOX2 protein, human; D055748:SOXB1 Transcription Factors
keywords: Sox2; digestive tract cancer; meta-analysis; prognosis