title: Investigating the cytotoxicity of platinum(II) complexes incorporating bidentate pyridyl-1,2,3-triazole "click" ligands.
abstract: Six platinum(II) complexes of the type [Pt(PL)(AL)]2+, where PLis a bidentate pyridyl-1,2,3-triazole "click" ligand and ALis the R,R or S,S isomer of 1.2-diaminocyclohexane, have been synthesised and characterised by several methods including elemental microanalysis, proton NMR spectroscopy and X-ray crystallography. The in vitro cytotoxicity of each complex was assessed in eleven cell lines, revealing moderate to good activity for complexes incorporating 2-(1-phenyl-1H-1,2,3-triazol-4-yl)pyridine.
authors.affiliation: Nanoscale Organisation and Dynamics Group, Western Sydney University, Campbelltown, NSW 2560, Australia.
authors.forename: Benjamin J
authors.initials: BJ
authors.lastname: Pages
authors.affiliation: Calvary Mater Newcastle, Waratah, NSW 2298, Australia.
authors.forename: Jennette
authors.initials: J
authors.lastname: Sakoff
authors.affiliation: Calvary Mater Newcastle, Waratah, NSW 2298, Australia.
authors.forename: Jayne
authors.initials: J
authors.lastname: Gilbert
authors.affiliation: Australian Nuclear Science and Technology Organisation, Locked Bag 2001, Kirrawee DC, NSW 2232, Australia.
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Nanoscale Organisation and Dynamics Group, Western Sydney University, Campbelltown, NSW 2560, Australia.
authors.forename: Feng
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Chemistry, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand.
authors.forename: Dan
authors.initials: D
authors.lastname: Preston
authors.affiliation: Department of Chemistry, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand.
authors.forename: James D
authors.initials: JD
authors.lastname: Crowley
authors.affiliation: Nanoscale Organisation and Dynamics Group, Western Sydney University, Campbelltown, NSW 2560, Australia. Electronic address: J.Aldrich-Wright@westernsydney.edu.au.
authors.forename: Janice R
authors.initials: JR
authors.lastname: Aldrich-Wright
mesh_terms: D002460:Cell Line; D057930:Click Chemistry; D018360:Crystallography, X-Ray; D003603:Cytotoxins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D061986:MCF-7 Cells; D009682:Magnetic Resonance Spectroscopy; D009944:Organoplatinum Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D003603:Cytotoxins; D009944:Organoplatinum Compounds; D014230:Triazoles
keywords: Cell growth inhibition; Click; Platinum; Triazole; X-ray crystal structure