title: Relationship between the Size of Magnetic Nanoparticles and Efficiency of MRT Imaging of Cerebral Glioma in Rats.
abstract: BSA-coated Fe3O4 nanoparticles with different hydrodynamic diameters (36±4 and 85±10 nm) were synthesized, zeta potential and T2 relaxivity were determined, and their morphology was studied by transmission electron microscopy. Studies on rats with experimental glioma C6 showed that smaller nanoparticles more effectively accumulated in the tumor and circulated longer in brain vessels. Optimization of the hydrodynamic diameter improves the efficiency of MRT contrast agent.
authors.affiliation: Department of Medical Nanobiotechnologies, Medical Biological Faculty, N. I. Pirogov Russian National Research Medical University, Moscow, Russia. alevtina.semkina@gmail.com.
authors.forename: A S
authors.initials: AS
authors.lastname: Semkina
authors.affiliation: Department of Medical Nanobiotechnologies, Medical Biological Faculty, N. I. Pirogov Russian National Research Medical University, Moscow, Russia.
authors.forename: M A
authors.initials: MA
authors.lastname: Abakumov
authors.affiliation: Electron Microscopy for Materials Science (EMAT), University of Antwerp, Groenenborgerlaan, Antwerp, Belgium.
authors.forename: A M
authors.initials: AM
authors.lastname: Abakumov
authors.affiliation: V. P. Serbsky Federal Medical Research Center of Psychiatry and Narcology, the Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Nukolova
authors.affiliation: Department of Medical Nanobiotechnologies, Medical Biological Faculty, N. I. Pirogov Russian National Research Medical University, Moscow, Russia.|V. P. Serbsky Federal Medical Research Center of Psychiatry and Narcology, the Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: V P
authors.initials: VP
authors.lastname: Chekhonin
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D001932:Brain Neoplasms / Q000000981:diagnostic imaging*; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000737:chemistry* / Q000493:pharmacokinetics; D005260:Female; D005910:Glioma / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D009368:Neoplasm Transplantation; D010316:Particle Size; D012710:Serum Albumin, Bovine / Q000737:chemistry
chemical_list: D003287:Contrast Media; D058185:Magnetite Nanoparticles; D012710:Serum Albumin, Bovine
keywords: MRT diagnosis; cerebral glioma; magnetic nanoparticles