title: Oxidative β-Csp(3) -H Functionalization of tBuOH: A Selective Radical/Radical Cross-Coupling Access to β-Hydroxy Thioethers.
abstract: An oxidative β-Csp(3) -H functionalization of tert-butanol (tBuOH) for the construction of C-S bonds through an iodine-catalyzed Csp(3) -H/S-H coupling was successfully achieved. Different kinds of mercaptans were shown to be good coupling partners, affording the desired products in good yields. This protocol not only offers a novel method for the synthesis of β-hydroxy thioethers, but also provides an effective strategy for selective radical/radical cross-coupling.
authors.affiliation: College of Chemistry and Molecular Sciences, the Institute for Advanced Studies (IAS), Wuhan University, Wuhan, Hubei, 430072, P. R. China.
authors.forename: Yuxiu
authors.initials: Y
authors.lastname: Li
authors.affiliation: College of Chemistry and Molecular Sciences, the Institute for Advanced Studies (IAS), Wuhan University, Wuhan, Hubei, 430072, P. R. China.
authors.forename: Dong
authors.initials: D
authors.lastname: Liu
authors.affiliation: College of Chemistry and Molecular Sciences, the Institute for Advanced Studies (IAS), Wuhan University, Wuhan, Hubei, 430072, P. R. China.
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
authors.affiliation: College of Chemistry and Molecular Sciences, the Institute for Advanced Studies (IAS), Wuhan University, Wuhan, Hubei, 430072, P. R. China. aiwenlei@whu.edu.cn.|National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang, 330022, Jiangxi, P. R. China. aiwenlei@whu.edu.cn.
authors.forename: Aiwen
authors.identifier: http://orcid.org/0000-0001-8417-3061
authors.initials: A
authors.lastname: Lei
keywords: iodine; mercaptans; radical oxidative coupling; β-hydroxy thioethers