title: An Achilles' Heel for MLL-Rearranged Leukemias: Writers and Readers of H3 Lysine 36 Dimethylation.
abstract: Histone H3 lysine 36 dimethylation (H3K36me2), a modification associated with transcriptional activation, is required for mixed-lineage leukemia-dependent transcription and leukemic transformation. In this issue of Cancer Discovery, Zhu and colleagues map the network of readers, writers, and erasers of H3K36me2 and uncover the ASH1L histone methyltransferase as a novel target for therapeutic intervention. Cancer Discov; 6(7); 700-2. ©2016 AACR.See related article by Zhu and colleagues, p. 770.
authors.affiliation: Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts. Harvard Medical School, Boston, Massachusetts.
authors.forename: Sebastian T
authors.initials: ST
authors.lastname: Balbach
authors.affiliation: Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts. Harvard Medical School, Boston, Massachusetts. Harvard Stem Cell Institute, Cambridge, Massachusetts. Howard Hughes Medical Institute, Boston, Massachusetts. Stuart_Orkin@dfci.harvard.edu.
authors.forename: Stuart H
authors.initials: SH
authors.lastname: Orkin
mesh_terms: D004268:DNA-Binding Proteins / Q000378:metabolism; D044127:Epigenesis, Genetic; D015973:Gene Expression Regulation, Leukemic; D006410:Hematopoiesis / Q000235:genetics; D011495:Histone-Lysine N-Methyltransferase; D006657:Histones / Q000378:metabolism*; D006801:Humans; D007938:Leukemia / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism*; D008239:Lysine / Q000378:metabolism; D008745:Methylation; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics*; D014157:Transcription Factors / Q000378:metabolism; D014178:Translocation, Genetic
chemical_list: D004268:DNA-Binding Proteins; D006657:Histones; D014157:Transcription Factors; D051788:Myeloid-Lymphoid Leukemia Protein; C490911:ASH1L protein, human; D011495:Histone-Lysine N-Methyltransferase; D008239:Lysine