title: Antimalarial Phenanthroindolizine Alkaloids from Ficus septica.
abstract: During the screening of antimalarial substances, MeOH extract from the twigs of Ficus septica was shown to have potent antimalarial activity. Bioassay-guided fractionation of a methanol extract of the twigs of F. septica led to the isolation of a new seco-phenanthroindolizine alkaloid and three known phenanthroindolizine alkaloids. Their structures were elucidated on the basis of NMR analysis. All isolated compounds were tested against Plasmodium falciparum. Compounds 2-4 displayed antimalarial activity against the 3D7 strain of P. falciparum with IC50 values 0.028-0.42 µM, whereas a new compound 1 exhibited a moderate antimalarial activity.
authors.affiliation: Faculty of Pharmaceutical Sciences, Tokushima Bunri University.
authors.forename: Miwa
authors.initials: M
authors.lastname: Kubo
authors.forename: Wataru
authors.initials: W
authors.lastname: Yatsuzuka
authors.forename: Shoko
authors.initials: S
authors.lastname: Matsushima
authors.forename: Kenichi
authors.initials: K
authors.lastname: Harada
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Inoue
authors.forename: Hisashi
authors.initials: H
authors.lastname: Miyamoto
authors.forename: Makoto
authors.initials: M
authors.lastname: Matsumoto
authors.forename: Yoshiyasu
authors.initials: Y
authors.lastname: Fukuyama
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D030681:Ficus / Q000737:chemistry*; D015394:Molecular Structure; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000470:Alkaloids; D000962:Antimalarials