title: [Standard of care of carcinomas on cancer of unknown primary site in 2016].
abstract: Patients with Cancer of unknown primary (cup) represent 2-10%, and have disseminated cancers for which we cannot find the primary site despite the clinical, pathological and radiological exams at our disposal. Diagnosis is based on a thorough clinical and histopathologic examination as well as new imaging techniques. Several clinicopathologic entities requiring specific treatment can be identified. Genome sequencing and liquid biopsy (circulating tumor cells and tumor free DNA) could allow further advances in the diagnosis. Therapeutically, in addition to surgery, radiotherapy and chemotherapy, precision medicine provides new therapeutic approaches.
authors.affiliation: Gustave-Roussy Cancer Campus, département d'oncologie médicale, 114, rue Édouard-Vaillant, 94800 Villejuif, France.
authors.forename: Marc-Antoine
authors.initials: MA
authors.lastname: Benderra
authors.affiliation: CHU de Nice, hôpital Pasteur, laboratoire de pathologie clinique et expérimentale, 06000 Nice, France; Université de Nice Sophia Antipolis, faculté de médecine, Ircan Inserm U1081/CNRS UMR 7284, 06000 Nice, France; CHU de Nice, fédération hospitalo-universitaire OncoAge, 06000 Nice, France.
authors.forename: Marius
authors.initials: M
authors.lastname: Ilié
authors.affiliation: CHU de Nice, hôpital Pasteur, laboratoire de pathologie clinique et expérimentale, 06000 Nice, France; Université de Nice Sophia Antipolis, faculté de médecine, Ircan Inserm U1081/CNRS UMR 7284, 06000 Nice, France; CHU de Nice, fédération hospitalo-universitaire OncoAge, 06000 Nice, France; CHU de Nice, hôpital Pasteur, Biobanque hospitalière (BB 0025-00033), 06000 Nice, France.
authors.forename: Paul
authors.initials: P
authors.lastname: Hofman
authors.affiliation: Gustave-Roussy Cancer Campus, département d'oncologie médicale, 114, rue Édouard-Vaillant, 94800 Villejuif, France. Electronic address: Christophe.MASSARD@gustaveroussy.fr.
authors.forename: Christophe
authors.initials: C
authors.lastname: Massard
mesh_terms: D000465:Algorithms; D006801:Humans; D009382:Neoplasms, Unknown Primary / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy; D009360:Neoplastic Cells, Circulating; D027383:Papillomaviridae / Q000302:isolation & purification; D011379:Prognosis; D035583:Rare Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy; D059039:Standard of Care
keywords: Biopsie liquide; Cancer of unknown primary; Carcinome de primitif inconnu; Chemotherapy; Chimiothérapie; Genome sequencing; Immunohistochemistry; Immunohistochimie; Liquid biopsy; Médecine de précision; Precision medicine; Séquençage du génome