title: Arterial stiffness parameters associated with vitamin D deficiency and supplementation in patients with normal cardiac functions.
abstract: OBJECTIVE
  Arterial stiffness parameters including pulse wave velocity (PWV) and augmentation index (AIx) are associated with increased risk of cardiovascular disease. A close relationship has been demonstrated between vitamin D deficiency and cardiovascular disease. The aim of the present study was to investigate effects of vitamin D deficiency and supplementation on arterial stiffness parameters in patients with normal cardiac functions.
  
  
  METHODS
  Study population consisted of 45 patients with vitamin D deficiency and normal cardiac functions. Median age (interquartile range) was 45.0 (12.00) years, and 33 patients were female. Patients were treated with oral administration of vitamin D3. Arterial stiffness parameters were evaluated using Mobil-O-Graph arteriograph system, which detected signals from the brachial artery before and after treatment.
  
  
  RESULTS
  Vitamin D levels significantly increased after treatment (9.0 [6.00] nmol/L vs 29.0 [11.50] nmol/L, p<0.001). No significant difference was observed among conventional echocardiographic parameters before or after treatment. Post-treatment PVW and AIx were significantly lower than baseline measurements (6.8 [1.55] m/s vs 6.4 [1.30] m/s, p<0.001 and 23.0 [22.00]% vs 31.0 [14.50]%, p<0.001, respectively). Baseline vitamin D levels significantly correlated with PWV (r=-0.352, p=0.018). Post-treatment vitamin D levels also significantly correlated with post-treatment PWV (r=-0.442, p=0.002) and AIx (r=-0.419, p=0.004). Multivariate linear regression analysis revealed no independent predictor of baseline log-transformed PWV.
  
  
  CONCLUSIONS
  Vitamin D supplementation has beneficial effects on arterial stiffness. Arterial stiffness parameters may aid in the assessment of cardiovascular risk in patients with vitamin D deficiency.
authors.affiliation: Department of Cardiology, Marmara University Faculty of Medicine, İstanbul, Turkey. drsunbul@yahoo.com.tr.
authors.forename: Murat
authors.initials: M
authors.lastname: Sünbül
authors.affiliation: Department of Cardiology, Marmara University Faculty of Medicine, İstanbul, Turkey.
authors.forename: Altuğ
authors.initials: A
authors.lastname: Çinçin
authors.affiliation: Department of Cardiology, Marmara University Faculty of Medicine, İstanbul, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Bozbay
authors.affiliation: Department of Cardiology, Marmara University Faculty of Medicine, İstanbul, Turkey.
authors.forename: Ceyhun
authors.initials: C
authors.lastname: Mammadov
authors.affiliation: Department of Cardiology, Marmara University Faculty of Medicine, İstanbul, Turkey.
authors.forename: Halil
authors.initials: H
authors.lastname: Ataş
authors.affiliation: Department of Internal Medicine, Şişli Hamidiye Etfal Training and Research Hospital, İstanbul, Turkey.
authors.forename: Ekmel Burak
authors.initials: EB
authors.lastname: Özşenel
authors.affiliation: Department of Cardiology, Marmara University Faculty of Medicine, İstanbul, Turkey.
authors.forename: İbrahim
authors.initials: İ
authors.lastname: Sarı
authors.affiliation: Department of Cardiology, Marmara University Faculty of Medicine, İstanbul, Turkey.
authors.forename: Yelda
authors.initials: Y
authors.lastname: Başaran
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases; D005260:Female; D006439:Hemodynamics; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D059289:Vascular Stiffness / Q000502:physiology*; D014807:Vitamin D / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000453:epidemiology* / Q000503:physiopathology
chemical_list: D014807:Vitamin D