title: [Association between MKK4 promoter-1304T/G polymorphism and genetic susceptibility in sporadic nasopharyngeal carcinoma].
abstract: OBJECTIVE
  To investigate the association between-1304T/G polymorphism in the promoter of MKK4 gene and the susceptibility in sporadic nasopharyngeal carcinoma.
  
  
  METHODS
  MKK4-1304T/G genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 90 NPC cases and 30 healthy controls.
  
  
  RESULTS
  The number of nasopharyngeal carcinoma patients carrying with TG+GG genotype was much higher than those of controls (82.2% vs 66.7%, χ² =10.076, P < 0.05). Analysis showed that compared with the-1304TT genotype, -1304TG heterozygous reduced risk of nasopharyngeal carcinoma 0.56 fold (95% CI = 0.164-1.178, P < 0.01) and-1304GG lower 0.58 fold (95% CI = 0.126-1.381, P < 0.01), TG+ GG genotype variation risk of nasopharyngeal carcinoma decreased 0.72 fold (95% CI = 0.105-0.753, P < 0.01).
  
  
  CONCLUSIONS
  MKK4 gene-1304TG genotype can reduce risk of nasopharyngeal carcinoma, and it may be an independent protection factor in sporadic nasopharyngeal carcinoma.
authors.forename: Mingqian
authors.initials: M
authors.lastname: Lu
authors.forename: Qingzhi
authors.initials: Q
authors.lastname: Kong
authors.forename: Xinhua
authors.initials: X
authors.lastname: Xu
authors.forename: Hongda
authors.initials: H
authors.lastname: Lu
authors.forename: Zhongxin
authors.initials: Z
authors.lastname: Lu
authors.forename: Kezhi
authors.initials: K
authors.lastname: Shi
authors.forename: Bingqing
authors.initials: B
authors.lastname: Xu
authors.forename: Rong
authors.initials: R
authors.lastname: Guo
mesh_terms: D002277:Carcinoma; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D048670:MAP Kinase Kinase 4 / Q000235:genetics*; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D011401:Promoter Regions, Genetic
chemical_list: D048670:MAP Kinase Kinase 4; C482559:MAP2K4 protein, human