title: Robust aptamer-polydopamine-functionalized M-PLGA-TPGS nanoparticles for targeted delivery of docetaxel and enhanced cervical cancer therapy.
abstract: One limitation of current biodegradable polymeric nanoparticles (NPs) is the contradiction between functional modification and maintaining formerly excellent bioproperties with simple procedures. Here, we reported a robust aptamer-polydopamine-functionalized mannitol-functionalized poly(lactide-co-glycolide) (M-PLGA)-D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) nanoformulation (Apt-pD-NPs) for the delivery of docetaxel (DTX) with enhanced cervical cancer therapy effects. The novel DTX-loaded Apt-pD-NPs possess satisfactory advantages: 1) increased drug loading content and encapsulation efficiency induced by star-shaped copolymer M-PLGA-TPGS; 2) significant active targeting effect caused by conjugated AS1411 aptamers; and 3) excellent long-term compatibility by incorporation of TPGS. Therefore, with simple preparation procedures and excellent bioproperties, the new functionalized Apt-pD-NPs could maximally increase the local effective drug concentration on tumor sites, achieving enhanced treatment effectiveness and minimizing side effects. In a word, the robust DTX-loaded Apt-pD-NPs could be used as potential nanotherapeutics for cervical cancer treatment, and the aptamer-polydopamine modification strategy could be a promising method for active targeting of cancer therapy with simple procedures.
authors.affiliation: School of Life Sciences, Tsinghua University, Beijing; Graduate School at Shenzhen, Tsinghua University, Shenzhen; School of Materials Science and Engineering, Tsinghua University, Beijing.
authors.forename: Guojun
authors.initials: G
authors.lastname: Xu
authors.affiliation: Graduate School at Shenzhen, Tsinghua University, Shenzhen.
authors.forename: Xinghua
authors.initials: X
authors.lastname: Yu
authors.affiliation: School of Life Sciences, Tsinghua University, Beijing; Graduate School at Shenzhen, Tsinghua University, Shenzhen.
authors.forename: Jinxie
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Orthopedic Surgery, Changshu Hospital of TCM, Changshu, People's Republic of China.
authors.forename: Yingchao
authors.initials: Y
authors.lastname: Sheng
authors.affiliation: Graduate School at Shenzhen, Tsinghua University, Shenzhen.
authors.forename: Gan
authors.initials: G
authors.lastname: Liu
authors.affiliation: School of Life Sciences, Tsinghua University, Beijing; Graduate School at Shenzhen, Tsinghua University, Shenzhen.
authors.forename: Wei
authors.initials: W
authors.lastname: Tao
authors.affiliation: School of Life Sciences, Tsinghua University, Beijing; Graduate School at Shenzhen, Tsinghua University, Shenzhen.
authors.forename: Lin
authors.initials: L
authors.lastname: Mei
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D052157:Aptamers, Nucleotide / Q000737:chemistry; D000077143:Docetaxel; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D016503:Drug Delivery Systems / Q000379:methods*; D005260:Female; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D007211:Indoles / Q000737:chemistry; D019344:Lactic Acid / Q000737:chemistry; D016513:Mice, SCID; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry; D043823:Taxoids / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy*; D014810:Vitamin E / Q000737:chemistry; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D052157:Aptamers, Nucleotide; D004337:Drug Carriers; D007211:Indoles; D011108:Polymers; D043823:Taxoids; C568283:polydopamine; D014810:Vitamin E; D000077143:Docetaxel; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D011092:Polyethylene Glycols; C014225:tocophersolan
keywords: AS1411 aptamer; active targeting; dopamine; enhanced cervical chemotherapy; polymeric NPs