title: Influence of catheter insertion on the hemodynamic environment in coronary arteries.
abstract: Intravascular stenting is one of the most commonly used treatments to restore the vascular lumen and flow conditions, while perioperative complications such as thrombosis and restenosis are still nagging for patients. As the catheter with crimped stent and folded balloon is directly advanced through coronary artery during surgery, it is destined to cause interference as well as obstructive effect on blood flow. We wonder how the hemodynamic environment would be disturbed and weather these disturbances cause susceptible factors for those complications. Therefore, a realistic three-dimensional model of left coronary artery was reconstructed and blood flow patterns were numerically simulated at seven different stages in the catheter insertion process. The results revealed that the wall shear stress (WSS) and velocity in left anterior descending (LAD) were both significantly increased after catheter inserted into LAD. Besides, the WSS on the catheter, especially at the ending of the catheter, was also at high level. Compared with the condition before catheter inserted, the endothelial cells of LAD was exposed to high-WSS condition and the risk of platelet aggregation in blood flow was increased. These influences may make coronary arteries more vulnerable for perioperative complications.
authors.affiliation: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, International Joint Research Center of Aerospace Biotechnology & Medical Engineering, Ministry of Science and Technology, School of Biological Science and Medical Engineering, Beihang University, 100191 Beijing, China.
authors.forename: Xiaopeng
authors.initials: X
authors.lastname: Tian
authors.affiliation: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, International Joint Research Center of Aerospace Biotechnology & Medical Engineering, Ministry of Science and Technology, School of Biological Science and Medical Engineering, Beihang University, 100191 Beijing, China. Electronic address: saq@buaa.edu.cn.
authors.forename: Anqiang
authors.initials: A
authors.lastname: Sun
authors.affiliation: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, International Joint Research Center of Aerospace Biotechnology & Medical Engineering, Ministry of Science and Technology, School of Biological Science and Medical Engineering, Beihang University, 100191 Beijing, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Liu
authors.affiliation: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, International Joint Research Center of Aerospace Biotechnology & Medical Engineering, Ministry of Science and Technology, School of Biological Science and Medical Engineering, Beihang University, 100191 Beijing, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Pu
authors.affiliation: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, International Joint Research Center of Aerospace Biotechnology & Medical Engineering, Ministry of Science and Technology, School of Biological Science and Medical Engineering, Beihang University, 100191 Beijing, China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Deng
authors.affiliation: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, International Joint Research Center of Aerospace Biotechnology & Medical Engineering, Ministry of Science and Technology, School of Biological Science and Medical Engineering, Beihang University, 100191 Beijing, China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Kang
authors.affiliation: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, International Joint Research Center of Aerospace Biotechnology & Medical Engineering, Ministry of Science and Technology, School of Biological Science and Medical Engineering, Beihang University, 100191 Beijing, China. Electronic address: yubofan@buaa.edu.cn.
authors.forename: Yubo
authors.initials: Y
authors.lastname: Fan
mesh_terms: D057785:Catheters; D003331:Coronary Vessels / Q000033:anatomy & histology* / Q000000981:diagnostic imaging / Q000502:physiology*; D006439:Hemodynamics; D007091:Image Processing, Computer-Assisted; D008953:Models, Anatomic; D033081:Shear Strength; D013314:Stress, Mechanical; D014057:Tomography, X-Ray Computed
keywords: Catheterization; Numerical simulation; Percutaneous coronary intervention; Wall shear stress