title: The role of the FTD-ALS associated C9orf72 expansion in suicide victims.
abstract: Impulsive and aggressive traits are not only common features displayed by patients with behavioural variant frontotemporal dementia (bvFTD), they may well be the first clinical manifestations of the disease. In addition, suicidal behaviour has been postulated to be a symptom of bvFTD. A hexanucleotide repeat expansion in chromosome 9 open reading frame 72 (C9orf72) is the major genetic cause for familial bvFTD. During recent years, several genetic factors predisposing to suicide have been identified, but there are no previous studies analysing the role of the C9orf72 expansion in suicides. In the present study, we aimed to analyse the prevalence of the C9orf72 expansion in unselected suicide victims. The prevalence of the C9orf72 expansion was analysed in a cohort of 109 Finnish victims of suicide (mean age at death 46.1 years; range 18-86 years). The C9orf72 expansion was analysed from the post mortem blood samples. Results showed that no abnormal length C9orf72 expansions were detected in the study cohort. In conclusion, even though suicidal behaviour may be encountered in bvFTD patients, the C9orf72 expansion is not a common genetic finding in unselected suicide victims.
authors.affiliation: a Institute of Clinical Medicine - Neurology, University of Eastern Finland , Yliopistonranta , Kuopio , Finland.
authors.forename: Eino
authors.initials: E
authors.lastname: Solje
authors.affiliation: b Department of Psychiatry , Institute of Clinical Medicine, University of Oulu , Peltolantie 17 , Oulu , Finland.
authors.forename: Pirkko
authors.initials: P
authors.lastname: Riipinen
authors.affiliation: a Institute of Clinical Medicine - Neurology, University of Eastern Finland , Yliopistonranta , Kuopio , Finland.
authors.forename: Seppo
authors.initials: S
authors.lastname: Helisalmi
authors.affiliation: c National Institute for Health and Welfare , Aapistie 1 , Oulu , Finland.
authors.forename: Terttu
authors.initials: T
authors.lastname: Särkioja
authors.affiliation: a Institute of Clinical Medicine - Neurology, University of Eastern Finland , Yliopistonranta , Kuopio , Finland.|d Department of Neurology , Kuopio University Hospital , Puijonlaaksontie 2 , Kuopio , Finland.
authors.forename: Marjo
authors.initials: M
authors.lastname: Laitinen
authors.affiliation: a Institute of Clinical Medicine - Neurology, University of Eastern Finland , Yliopistonranta , Kuopio , Finland.|d Department of Neurology , Kuopio University Hospital , Puijonlaaksontie 2 , Kuopio , Finland.|e Institute of Biomedicine, University of Eastern Finland , Yliopistonranta 1 , Kuopio , Finland , and.
authors.forename: Mikko
authors.initials: M
authors.lastname: Hiltunen
authors.affiliation: f Department of Psychiatry , Oulu University Hospital , Peltolantie 17 , Oulu , Finland.
authors.forename: Helinä
authors.initials: H
authors.lastname: Hakko
authors.affiliation: a Institute of Clinical Medicine - Neurology, University of Eastern Finland , Yliopistonranta , Kuopio , Finland.|d Department of Neurology , Kuopio University Hospital , Puijonlaaksontie 2 , Kuopio , Finland.
authors.forename: Anne M
authors.initials: AM
authors.lastname: Remes
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000690:Amyotrophic Lateral Sclerosis / Q000150:complications / Q000235:genetics* / Q000523:psychology*; D000073885:C9orf72 Protein; D042622:DNA Repeat Expansion / Q000235:genetics*; D005260:Female; D005387:Finland / Q000453:epidemiology; D057180:Frontotemporal Dementia / Q000150:complications / Q000235:genetics* / Q000523:psychology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011506:Proteins / Q000235:genetics*; D012189:Retrospective Studies; D013405:Suicide / Q000523:psychology; D055815:Young Adult
chemical_list: D000073885:C9orf72 Protein; C568651:C9orf72 protein, human; D011506:Proteins
keywords: C9orf72; Suicide; frontal lobe; frontotemporal dementia; genetics; impulsivity