title: Clinical and Echocardiographic Characteristics of Acute Cardiac Dysfunction Associated With Acute Brain Hemorrhage　- Difference From Takotsubo Cardiomyopathy.
abstract: BACKGROUND
  Cardiac dysfunction (CD) associated with brain hemorrhage is similar to that with takotsubo cardiomyopathy but still not well understood. We aimed to investigate the clinical and echocardiographic findings of acute CD (ACD) related to brain hemorrhage.
  
  
  RESULTS
  Between 2013 and 2014, consecutive patients diagnosed with spontaneous and traumatic brain hemorrhage were prospectively enrolled. Electrocardiography, cardiac enzymes, and echocardiography were performed. Left ventricular (LV) systolic dysfunction on echocardiography was defined as ACD related to brain hemorrhage when all the following conditions were satisfied: abnormal ECG and cardiac troponin level, LV wall motion abnormality or decreased LV systolic function on echocardiography, and no previous history of cardiac disease. Otherwise, LV dysfunction was considered to be other CD unrelated to brain hemorrhage. In a total of 208 patients, 15 (7.2%) showed ACD. Of them, 8 patients were men and 8 showed apex-sparing LV hypokinesia and 9 died in hospital. Other cardiac abnormalities observed in the study patients were NT-proBNP elevation (n=123), QT interval prolongation (n=95), LV hypertrophy (n=89), and troponin I elevation (n=47). There were 36 in-hospital deaths (17.3%). Glasgow coma score and ACD were independently associated with in-hospital death.
  
  
  CONCLUSIONS
  ACD was observed in patients with various brain hemorrhages. Unlike takotsubo cardiomyopathy, high proportions of male sex, apex-sparing LV dysfunction, and in-hospital death were observed for ACD associated with brain hemorrhage. (Circ J 2016; 80: 2026-2032).
authors.affiliation: Division of Cardiology, Department of Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine.
authors.forename: Mirae
authors.initials: M
authors.lastname: Lee
authors.forename: Ju Hyeon
authors.initials: JH
authors.lastname: Oh
authors.forename: Kyung Been
authors.initials: KB
authors.lastname: Lee
authors.forename: Gu Hyun
authors.initials: GH
authors.lastname: Kang
authors.forename: Yong Hwan
authors.initials: YH
authors.lastname: Park
authors.forename: Woo Jin
authors.initials: WJ
authors.lastname: Jang
authors.forename: Woo Jung
authors.initials: WJ
authors.lastname: Chun
authors.forename: Sang Hyuk
authors.initials: SH
authors.lastname: Lee
authors.forename: In Chang
authors.initials: IC
authors.lastname: Lee
mesh_terms: D000208:Acute Disease; D000368:Aged; D004452:Echocardiography; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000097:blood / Q000150:complications / Q000503:physiopathology; D020300:Intracranial Hemorrhages / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D012737:Sex Factors; D054549:Takotsubo Cardiomyopathy / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology; D019210:Troponin I / Q000097:blood*
chemical_list: D010446:Peptide Fragments; D019210:Troponin I; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain