title: Photocatalytic and antibacterial response of biosynthesized gold nanoparticles.
abstract: Increase in the bacterial resistance to available antibiotics and water contamination by different toxic organic dyes are both severe problems throughout the world. To overcome these concerns, new methodologies including synthesis of nontoxic, human friendly and efficient nanoparticles is required. These nanoparticles not even inhibit the growth of microorganisms but are also effective in the degradation of toxic organics in waste water thus providing a clean and human friendly environment. The use of plants extracts to synthesize and stabilize noble metal nanoparticles have been considered as safe, cost-effective, eco-benign and green approach nowadays. In the present study, Longan fruit juice proficiently reduced ionic gold (Au(+3)) to gold nanoparticles (AuNPs) as well as mediated the stabilization of AuNPs. The antibacterial activity of AuNPs was carried out against both gram positive and gram negative bacteria using agar well diffusion method, followed by the determination of Minimum inhibitory concentration (MIC) values. AuNPs were found to have significant antibacterial activity against Escherichia coli with MIC values of 75μg/ml while outstanding MIC values of 50μg/ml against Staphylococcus areous and Basilus subtilus. AuNPs revealed significant photocatalytic degradation (76%) of methylene blue in time period of 55min, indicating the effective photocatalytic property of biosynthesized AuNPs (K=0.29/min, r(2)=0.95). The considerable antibacterial and photocatalytic activities of the photosynthesized AuNPs can be attributed towards their small size, spherical morphology and uniform dispersion. Our finding suggests the possible therapeutic potential of biogenic AuNPs in the development of new antibacterial agents as well as in the development of effective photocatalysts.
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China. Electronic address: khanbuct@gmail.com.
authors.forename: Arif Ullah
authors.initials: AU
authors.lastname: Khan
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China. Electronic address: yuanqp@mail.buct.edu.cn.
authors.forename: Qipeng
authors.initials: Q
authors.lastname: Yuan
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Wei
authors.affiliation: Department of Pharmacy, Quaid-i-Azam University, Islamabad 45320, Pakistan.
authors.forename: Gul Majid
authors.initials: GM
authors.lastname: Khan
authors.affiliation: Department of Chemistry, University of Science and Technology Bannu, KP, Pakistan.
authors.forename: Zia Ul Haq
authors.initials: ZUH
authors.lastname: Khan
authors.affiliation: Institute of Chemical Sciences, Gomal University D.I.Khan, KP, Pakistan.
authors.forename: Shafiullah
authors.initials: S
authors.lastname: Khan
authors.affiliation: Department of Chemistry, Shaheed Benazir Bhutto University, Sheringal, Dir 18000, KP, Pakistan.
authors.forename: Farman
authors.initials: F
authors.lastname: Ali
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China.
authors.forename: Kamran
authors.initials: K
authors.lastname: Tahir
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China.
authors.forename: Aftab
authors.initials: A
authors.lastname: Ahmad
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China.
authors.forename: Faheem Ullah
authors.initials: FU
authors.lastname: Khan
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic; D006046:Gold / Q000737:chemistry* / Q000494:pharmacology*; D055772:Green Chemistry Technology; D053768:Metal Nanoparticles; D008826:Microbial Sensitivity Tests; D036103:Nanotechnology; D010316:Particle Size; D055668:Photochemical Processes
chemical_list: D000900:Anti-Bacterial Agents; D006046:Gold
keywords: Antibacterial activity; Biosynthesis; Gold nanoparticles; Photocatalysts