title: Assessment of Diagnostic and Prognostic Role of Copeptin in the Clinical Setting of Sepsis.
abstract: The diagnostic and prognostic usefulness of copeptin were evaluated in septic patients, as compared to procalcitonin assessment. In this single centre and observational study 105 patients were enrolled: 24 with sepsis, 25 with severe sepsis, 15 with septic shock, and 41 controls, divided in two subgroups (15 patients with gastrointestinal bleeding and 26 with suspected SIRS secondary to trauma, acute coronary syndrome, and pulmonary embolism). Biomarkers were determined at the first medical evaluation and thereafter 24, 48, and 72 hours after admission. Definitive diagnosis and in-hospital survival rates at 30 days were obtained through analysis of medical records. At entry, copeptin proved to be able to distinguish cases from controls and also sepsis group from septic shock group, while procalcitonin could distinguish also severe sepsis from septic shock group. Areas under the ROC curve for copeptin and procalcitonin were 0.845 and 0.861, respectively. Noteworthy, patients with copeptin concentrations higher than the threshold value (23.2 pmol/L), calculated from the ROC curve, at admission presented higher 30-day mortality. No significant differences were found in copeptin temporal profile among different subgroups. Copeptin showed promising diagnostic and prognostic role in the management of sepsis, together with its possible role in monitoring the response to treatment.
authors.affiliation: Emergency Medicine Department, "Città della Salute e della Scienza" University Hospital of Turin, Corso Bramante 88, 10126 Turin, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Battista
authors.affiliation: Emergency Medicine Department, "Città della Salute e della Scienza" University Hospital of Turin, Corso Bramante 88, 10126 Turin, Italy.
authors.forename: Umberto
authors.initials: U
authors.lastname: Audisio
authors.affiliation: Emergency Medicine Department, "Città della Salute e della Scienza" University Hospital of Turin, Corso Bramante 88, 10126 Turin, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Galluzzo
authors.affiliation: Emergency Medicine Department, "Città della Salute e della Scienza" University Hospital of Turin, Corso Bramante 88, 10126 Turin, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Maggiorotto
authors.affiliation: Emergency Medicine Department, "Città della Salute e della Scienza" University Hospital of Turin, Corso Bramante 88, 10126 Turin, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Masoero
authors.affiliation: Emergency Medicine Department, "Città della Salute e della Scienza" University Hospital of Turin, Corso Bramante 88, 10126 Turin, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Forno
authors.affiliation: Emergency Medicine Department, "Città della Salute e della Scienza" University Hospital of Turin, Corso Bramante 88, 10126 Turin, Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Pizzolato
authors.affiliation: Emergency Medicine Department, "Città della Salute e della Scienza" University Hospital of Turin, Corso Bramante 88, 10126 Turin, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Ulla
authors.affiliation: Clinical Biochemistry Laboratory, "Città della Salute e della Scienza" University Hospital of Turin, Corso Bramante 88, 10126 Turin, Italy.
authors.forename: Manuela
authors.initials: M
authors.lastname: Lucchiari
authors.affiliation: Clinical Biochemistry Laboratory, "Città della Salute e della Scienza" University Hospital of Turin, Corso Bramante 88, 10126 Turin, Italy.
authors.forename: Annarita
authors.initials: A
authors.lastname: Vitale
authors.affiliation: Emergency Medicine Department, "Città della Salute e della Scienza" University Hospital of Turin, Corso Bramante 88, 10126 Turin, Italy.
authors.forename: Corrado
authors.initials: C
authors.lastname: Moiraghi
authors.affiliation: Emergency Medicine Department, "Città della Salute e della Scienza" University Hospital of Turin, Corso Bramante 88, 10126 Turin, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Lupia
authors.affiliation: Clinical Biochemistry Laboratory, "Città della Salute e della Scienza" University Hospital of Turin, Corso Bramante 88, 10126 Turin, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Settanni
authors.affiliation: Clinical Biochemistry Laboratory, "Città della Salute e della Scienza" University Hospital of Turin, Corso Bramante 88, 10126 Turin, Italy.
authors.forename: Giulio
authors.initials: G
authors.lastname: Mengozzi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D005260:Female; D006471:Gastrointestinal Hemorrhage; D006020:Glycopeptides / Q000097:blood*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012372:ROC Curve; D018805:Sepsis / Q000097:blood* / Q000175:diagnosis* / Q000401:mortality; D055815:Young Adult
chemical_list: D015415:Biomarkers; D006020:Glycopeptides; C048197:copeptins