title: Changes in Central Aortic Pressure Levels, Wave Components and Determinants Associated with High Peripheral Blood Pressure States in Childhood: Analysis of Hypertensive Phenotype.
abstract: The aims were to determine whether children's high peripheral blood pressure states (HBP) are associated with increased central aortic blood pressure (BP) and to characterize hemodynamic and vascular changes associated with HBP in terms of changes in cardiac output (stroke volume, SV), arterial stiffness (aortic pulse wave velocity, PWV), peripheral vascular resistances (PVR) and net and relative contributions of reflected waves to the aortic pulse amplitude. We included 154 subjects (mean age 11; range 4-16 years) assigned to one of two groups: normal peripheral BP (NBP, n = 101), defined as systolic and diastolic BP < 90th percentile, or high BP (HBP, n = 53), defined as average systolic and/or diastolic BP levels ≥90th percentile (curves for sex, age and body height). The HBP group included children with hypertensive and pre-hypertensive BP levels. After a first analysis, groups were compared excluding obese and dyslipidemic children. Peripheral and central aortic BP, PWV and pulse wave-derived parameters (augmentation index, forward and backward wave components' amplitude) were measured using gold-standard techniques, applanation tonometry (SphygmoCor) and oscillometry (Mobil-O-Graph). Independent of the presence of dyslipidemia and/or obesity, aortic systolic and pulse BP were higher in HBP than in NBP children. The increase in central BP could not be explained by an increase in the relative contribution of reflections to the aortic pressure wave, higher PVR or by an augmented peripheral reflection coefficient. Instead, the rise in central BP would be explained by an increase in the amplitude of both incident and reflected wave components.
authors.affiliation: Physiology Department, Faculty of Medicine, Centro Universitario de Investigación, Innovación y Diagnóstico Arterial (CUiiDARTE), Republic University, General Flores 2125, 11800, Montevideo, Uruguay.
authors.forename: Victoria
authors.initials: V
authors.lastname: García-Espinosa
authors.affiliation: Physiology Department, Faculty of Medicine, Centro Universitario de Investigación, Innovación y Diagnóstico Arterial (CUiiDARTE), Republic University, General Flores 2125, 11800, Montevideo, Uruguay.
authors.forename: Santiago
authors.initials: S
authors.lastname: Curcio
authors.affiliation: Physiology Department, Faculty of Medicine, Centro Universitario de Investigación, Innovación y Diagnóstico Arterial (CUiiDARTE), Republic University, General Flores 2125, 11800, Montevideo, Uruguay.|Basic Medicine Department, Faculty of Medicine, Clinical Hospital, Republic University, Avenida Italia w/n, 11600, Montevideo, Uruguay.
authors.forename: Marco
authors.initials: M
authors.lastname: Marotta
authors.affiliation: Physiology Department, Faculty of Medicine, Centro Universitario de Investigación, Innovación y Diagnóstico Arterial (CUiiDARTE), Republic University, General Flores 2125, 11800, Montevideo, Uruguay.
authors.forename: Juan M
authors.initials: JM
authors.lastname: Castro
authors.affiliation: Pediatric Clinic "C", Faculty of Medicine, Pereira-Rossell Hospital Centre, Republic University, Boulevard Artigas 1550, 11600, Montevideo, Uruguay.
authors.forename: Maite
authors.initials: M
authors.lastname: Arana
authors.affiliation: Physiology Department, Faculty of Medicine, Centro Universitario de Investigación, Innovación y Diagnóstico Arterial (CUiiDARTE), Republic University, General Flores 2125, 11800, Montevideo, Uruguay.
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Peluso
authors.affiliation: Pediatric Cardiology Service, Pereira-Rossell Hospital Centre, ASSE, Boulevard Artigas 1550, 11600, Montevideo, Uruguay.
authors.forename: Pedro
authors.initials: P
authors.lastname: Chiesa
authors.affiliation: Pediatric Clinic "C", Faculty of Medicine, Pereira-Rossell Hospital Centre, Republic University, Boulevard Artigas 1550, 11600, Montevideo, Uruguay.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Giachetto
authors.affiliation: Physiology Department, Faculty of Medicine, Centro Universitario de Investigación, Innovación y Diagnóstico Arterial (CUiiDARTE), Republic University, General Flores 2125, 11800, Montevideo, Uruguay.
authors.forename: Daniel
authors.initials: D
authors.lastname: Bia
authors.affiliation: Physiology Department, Faculty of Medicine, Centro Universitario de Investigación, Innovación y Diagnóstico Arterial (CUiiDARTE), Republic University, General Flores 2125, 11800, Montevideo, Uruguay. yana@fmed.edu.uy.
authors.forename: Yanina
authors.initials: Y
authors.lastname: Zócalo
mesh_terms: D000293:Adolescent; D001011:Aorta; D062186:Arterial Pressure; D001794:Blood Pressure; D002648:Child; D002675:Child, Preschool; D006801:Humans; D006973:Hypertension; D010641:Phenotype; D063177:Pulse Wave Analysis; D059289:Vascular Stiffness
keywords: Arterial stiffness; Central aortic blood pressure; Hypertension; Pediatrics; Pulse wave velocity; Wave reflection parameters