title: A mini-review on functional nucleic acids-based heavy metal ion detection.
abstract: Recent years have witnessed great progress in developing functional nucleic acids (FNAs)-based sensors for the detection of heavy metal ion. In this review, four types of the FNAs that most widely-used in heavy metal ions detection were briefly introduced and a dozen of recently published review articles which summarized those FNAs-based sensors were introduced. Particularly, according to the degree of automation and system integration, those FNAs-based sensors which belong to the lab-on-a-chip (LOC) category were reviewed in more detail by classifying them into six types such as microfluidic LOC system, microchip, lateral flow dipstick, personal glucose meter, microfluidic paper-based analytical devices (μPADs) and disc-based analytical platform. After gave a brief description of the sensing strategies, properties, advantages or disadvantages of these FNAs-based sensors, existing problems and future perspectives were also discussed.
authors.affiliation: School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, PR China; School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, PR China; Key Laboratory of Urban Agriculture (South), Ministry of Agriculture, Shanghai 200240, PR China; Bor S. Luh Food Safety Research Center, Shanghai Jiao Tong University, Shanghai 200240, PR China.
authors.forename: Shenshan
authors.initials: S
authors.lastname: Zhan
authors.affiliation: Guizhou Province Key Laboratory of Fermentation Engineering and Biopharmacy, Guizhou University, Guiyang, 550025 Huaxi District, Guizhou, PR China; School of Liquor & Food Engineering, Guizhou University, Guiyang, 550025 Huaxi District, Guizhou, PR China.
authors.forename: Yuangen
authors.initials: Y
authors.lastname: Wu
authors.affiliation: School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, PR China; Key Laboratory of Urban Agriculture (South), Ministry of Agriculture, Shanghai 200240, PR China; Bor S. Luh Food Safety Research Center, Shanghai Jiao Tong University, Shanghai 200240, PR China.
authors.forename: Lumei
authors.initials: L
authors.lastname: Wang
authors.affiliation: School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, PR China; Key Laboratory of Urban Agriculture (South), Ministry of Agriculture, Shanghai 200240, PR China; Bor S. Luh Food Safety Research Center, Shanghai Jiao Tong University, Shanghai 200240, PR China.
authors.forename: Xuejia
authors.initials: X
authors.lastname: Zhan
authors.affiliation: School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, PR China; Key Laboratory of Urban Agriculture (South), Ministry of Agriculture, Shanghai 200240, PR China; Bor S. Luh Food Safety Research Center, Shanghai Jiao Tong University, Shanghai 200240, PR China. Electronic address: zhoupei@sjtu.edu.cn.
authors.forename: Pei
authors.initials: P
authors.lastname: Zhou
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D004784:Environmental Monitoring / Q000295:instrumentation*; D004785:Environmental Pollutants / Q000032:analysis / Q000737:chemistry; D004867:Equipment Design; D019544:Equipment Failure Analysis; D007477:Ions / Q000032:analysis / Q000737:chemistry; D056656:Lab-On-A-Chip Devices; D019216:Metals, Heavy / Q000032:analysis* / Q000737:chemistry; D015336:Molecular Probe Techniques / Q000295:instrumentation; D009696:Nucleic Acids / Q000737:chemistry* / Q000235:genetics; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D004785:Environmental Pollutants; D007477:Ions; D019216:Metals, Heavy; D009696:Nucleic Acids
keywords: Aptamer; DNAzyme; Functional nucleic acids; G-quadruplex; Heavy metal ion detection; Microfluidic sensor