title: EFFECT OF PREOPERATIVE INTRAVENOUS OXYCODONE ON LOW-DOSE ROPIVACAINE SPINAL ANESTHESIA COMBINED WITH INTRATHECAL FENTANYL.
abstract: BACKGROUND
  Low-dose ropivacaine combined with intrathecal fentanyl can provide adequate anaesthesia with minimal haemodynamic variation. Preemptive analgesia can enhance analgesic effect of spinal anaesthesia without obvious side effects.
  
  
  OBJECTIVE
  To assess the efficacy of preoperative intravenous oxycodone on transurethral resection of prostate (TURP) under 10 mg ropivacaine spinal anaesthesia combined with intrathecal 25 pg fentanyl.
  
  
  METHODS
  Sixty patients undergoing TURP were randomly divided into two groups: Group o (n=30), in which the patients were administered 0.1 mg.kg-1 oxycodone intravenously 10 min prior to the operation for 2 min, and Group C (n=30) in which the patients were administered intravenously a similar volume of 0.9% saline. The participants were injected with hyperbaric 10 mg ropivacaine and 25 µg fentanyl intrathecally. The block characteristics, hemodynamic values, the tramadol consumption and adverse effects were analyzed.
  
  
  RESULTS
  The peak level of sensory block was lower in Group C. Time to the first analgesic request and time to two-segment regression of sensory block were shorter in Group C. Fewer patients in Group 0 were given postoperative analgesics.
  
  
  CONCLUSIONS
  Preoperative intravenous oxycodone can prolong analgesic effect of this method and postoperative analgesia.
authors.forename: Na
authors.initials: N
authors.lastname: Wang
authors.forename: Songling
authors.initials: S
authors.lastname: Zhang
authors.forename: Yaowen
authors.initials: Y
authors.lastname: Fu
authors.forename: Jinguo
authors.initials: J
authors.lastname: Wang
mesh_terms: D000368:Aged; D000577:Amides / Q000008:administration & dosage*; D000701:Analgesics, Opioid / Q000008:administration & dosage*; D000775:Anesthesia, Spinal / Q000379:methods*; D005283:Fentanyl / Q000008:administration & dosage*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007278:Injections, Spinal; D008875:Middle Aged; D010098:Oxycodone / Q000008:administration & dosage*; D000077212:Ropivacaine
chemical_list: D000577:Amides; D000701:Analgesics, Opioid; D000077212:Ropivacaine; D010098:Oxycodone; D005283:Fentanyl