title: The value of serum pro-oxidant/antioxidant balance in the assessment of asphyxia in term neonates.
abstract: OBJECTIVE
  Asphyxia is a major cause of disabilities in term-born infants. Here we have explored the value in HIE (hypoxic-ischemic-encephalopathy) of using a combination of serum pro-oxidant/antioxidant balance (PAB) assay for predicting the prognosis of asphyxia.
  
  
  METHODS
  Ninety term neonates with asphyxia were enrolled and followed up for two years. Serum PAB, demographic/biochemical characteristics of mothers, and their neonates were determined. The Denver II test was used to assess outcomes.
  
  
  RESULTS
  Of the 90 asphyxiated neonates, 47 (52.2%) had a normal outcome and 43 babies (47.8%) had abnormal outcome. Serum PAB levels in neonates with normal and abnormal outcomes were 17.1 ± 9.23 and 48.27 ± 41.30 HK, respectively. A combination of HIE intensity and PAB, compared to other indicators, had a higher predictive-value (95.2%) for outcomes in asphyxiated babies.
  
  
  CONCLUSIONS
  We demonstrate that PAB in combination with HIE grade may have a better predictive value for the prognosis of asphyxiated babies and predicting future neurologic problems in asphyxiated term infants.
authors.affiliation: a Department of Pediatrics , Neonatal Research Center, Ghaem Hospital, Mashhad University of Medical Sciences (MUMS) , Mashhad , Iran.
authors.forename: Hassan
authors.initials: H
authors.lastname: Boskabadi
authors.affiliation: b Reproductive Health, Department of Midwifery, School of Medicine, Tonekabon Branch, Islamic Azad University , Tonekabon , Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Zakerihamidi
authors.affiliation: c Department of Pediatrics , Community Medicine and Public Health, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Heidarzadeh
authors.affiliation: d Department of Modern Sciences and Technologies , School of Medicine, Mashhad University of Medical Sciences , Mashhad , Iran.
authors.forename: Amir
authors.initials: A
authors.lastname: Avan
authors.affiliation: e Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences , Mashhad , Iran , and.
authors.forename: Majid
authors.initials: M
authors.lastname: Ghayour-Mobarhan
authors.affiliation: f Division of Medical Education , Brighton and Sussex Medical School , Brighton , UK.
authors.forename: Gordon A
authors.initials: GA
authors.lastname: Ferns
mesh_terms: D000975:Antioxidants / Q000032:analysis*; D001034:Apgar Score; D001238:Asphyxia Neonatorum / Q000097:blood* / Q000150:complications; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D002534:Hypoxia, Brain / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D007231:Infant, Newborn; D016877:Oxidants / Q000097:blood*; D011247:Pregnancy; D011446:Prospective Studies; D012372:ROC Curve; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
chemical_list: D000975:Antioxidants; D016877:Oxidants
keywords: Asphyxia; PAB balance; hypoxic ischemic encephalopathy; newborn