title: Principles of Antimicrobial Therapy in Older Adults.
abstract: Antibiotic use is common in older adults, and much of it is deemed unnecessary. Complications of antibiotic use may occur as a consequence of changes in age-related physiology and dosing with resulting drug toxicity and secondary infection. Knowing when it is appropriate to initiate antibiotics may help reduce unnecessary antibiotic use and prevent adverse drug events. Careful attention to antibiotic selection, dosing adjustments, and drug-drug interactions may also help prevent antibiotic-related adverse events.
authors.affiliation: Infectious Diseases Section 111i, Rm B804 Veterans Affairs Ann Arbor Healthcare System, 2215 Fuller Road, Ann Arbor, MI 48105, USA. Electronic address: sbradley@umich.edu.
authors.forename: Suzanne F
authors.initials: SF
authors.lastname: Bradley
mesh_terms: D000367:Age Factors; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D006801:Humans; D007239:Infections / Q000188:drug therapy*; D017410:Practice Guidelines as Topic
chemical_list: D000900:Anti-Bacterial Agents
keywords: Aging; Antibiotics; Antimicrobial stewardship; Long-term care; Pharmacokinetics