title: Relapse of both small cell lung cancer and Lambert-Eaton myasthenic syndrome after a 13-year disease-free survival period.
abstract: Lambert-Eaton myasthenic syndrome (LEMS) is a paraneoplastic syndrome and only 3% of small cell lung carcinoma (SCLC) patients have LEMS. Moreover, the recurrence of SCLC after a disease-free survival (DFS) of more than 10 years is rare. We report a patient who had a recurrence of both SCLC and LEMS after a 13-year DFS period. A 69-year-old man was diagnosed with LEMS and SCLC (cT0N2M0, stage IIIA) 13 years ago. Chemoradiotherapy was performed and a complete response was achieved. With anticancer treatment, the LEMS symptoms was alleviated. At the age of 82 years, gait disturbance appeared followed by left supraclavicular lymphadenopathy and further examination revealed the recurrence of SCLC. Careful screening for the recurrence of SCLC might be needed when the patient has recurrent or secondary paraneoplastic neurological syndrome even after a long DFS period.
authors.affiliation: Respiratory Disease Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, Yokohama, Kanagawa, 232-0024, Japan.
authors.forename: Fumio
authors.initials: F
authors.lastname: Asano
authors.affiliation: Respiratory Disease Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, Yokohama, Kanagawa, 232-0024, Japan. YCUmedRDCkw@yahoo.co.jp.|Department of Medicine, McMaster University, Hamilton, ON, Canada. YCUmedRDCkw@yahoo.co.jp.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Watanabe
authors.affiliation: Respiratory Disease Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, Yokohama, Kanagawa, 232-0024, Japan.
authors.forename: Masaharu
authors.initials: M
authors.lastname: Shinkai
authors.affiliation: Respiratory Disease Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, Yokohama, Kanagawa, 232-0024, Japan.
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Tei
authors.affiliation: Respiratory Disease Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, Yokohama, Kanagawa, 232-0024, Japan.
authors.forename: Kei
authors.initials: K
authors.lastname: Mishina
authors.affiliation: Department of Pathology, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, Yokohama, Kanagawa, 232-0024, Japan.
authors.forename: Mikiko
authors.initials: M
authors.lastname: Tanabe
authors.affiliation: Respiratory Disease Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, Yokohama, Kanagawa, 232-0024, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishii
authors.affiliation: Respiratory Disease Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, Yokohama, Kanagawa, 232-0024, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Shinoda
authors.affiliation: Comprehensive Cancer Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, Yokohama, Kanagawa, 232-0024, Japan.
authors.forename: Tadasuke
authors.initials: T
authors.lastname: Shimokawaji
authors.affiliation: Respiratory Disease Center, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, Yokohama, Kanagawa, 232-0024, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Kudo
authors.affiliation: Department of Pulmonology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kaneko
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D015624:Lambert-Eaton Myasthenic Syndrome / Q000209:etiology* / Q000628:therapy; D008175:Lung Neoplasms / Q000209:etiology* / Q000628:therapy; D008297:Male; D009364:Neoplasm Recurrence, Local; D055752:Small Cell Lung Carcinoma / Q000209:etiology* / Q000628:therapy
keywords: Lambert–Eaton myasthenic syndrome; P/Q-type anti-voltage-gated calcium channel antibody; Paraneoplastic neurological syndrome; Paraneoplastic syndrome; Small cell lung carcinoma