title: Antimalarial and cytotoxic quassinoids from the roots of Brucea javanica.
abstract: Two new quassinoids, brujavanol A (1) and brujavanol B (2), along with five known quassinoids (3-7), were isolated from the roots of Brucea javanica. Their structures were elucidated by spectroscopic methods. The antimalarial and cytotoxic activities of the isolated compounds were also assessed. Compounds 1 and 2 exhibited significant in vitro cytotoxicity against human oral cavity cancer (KB) cells with IC50values of 1.30 and 2.36 μg/ml, respectively, whereas compound 3 showed excellent antiplasmodial activity against the Plasmodium falciparum strains, K1 (IC50= 0.58 μg/ml).
authors.affiliation: a Faculty of Science and Industrial Technology , Prince of Songkla University , Suratthani Campus, Suratthani 84000 , Thailand.
authors.forename: Parinuch
authors.initials: P
authors.lastname: Chumkaew
authors.affiliation: a Faculty of Science and Industrial Technology , Prince of Songkla University , Suratthani Campus, Suratthani 84000 , Thailand.
authors.forename: Theera
authors.initials: T
authors.lastname: Srisawat
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D032269:Brucea / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects*; D036702:Quassins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000962:Antimalarials; D036702:Quassins; C000616454:brujavanol A; C000616455:brujavanol B
keywords: Brucea javanica; Simaroubaceae; antimalarial activity; cytotoxicity; quassinoid