title: Glycolysis inhibition as a cancer treatment and its role in an anti-tumour immune response.
abstract: Increased glycolysis is the main source of energy supply in cancer cells that use this metabolic pathway for ATP generation. Altered energy metabolism is a biochemical fingerprint of cancer cells that represents one of the "hallmarks of cancer". The immune system can prevent tumour growth by eliminating cancer cells but this editing process ultimately results in poorly immunogenic cells remaining allowing for unchallenged tumour growth. In this review we look at the glycolysis pathway as a target for cancer treatments. We also examine the interplay between the glycolysis modulation and the immune response as an anti-cancer therapy.
authors.affiliation: Cork Cancer Research Centre, Western Gateway Building, University College Cork, Cork, Ireland; Cardiothoracic Surgery Department, Cork University Hospital, Cork, Ireland.
authors.forename: Kheshwant S
authors.initials: KS
authors.lastname: Gill
authors.affiliation: Cork Cancer Research Centre, Western Gateway Building, University College Cork, Cork, Ireland.
authors.forename: Philana
authors.initials: P
authors.lastname: Fernandes
authors.affiliation: Cork Cancer Research Centre, Western Gateway Building, University College Cork, Cork, Ireland.
authors.forename: Tracey R
authors.initials: TR
authors.lastname: O'Donovan
authors.affiliation: Cork Cancer Research Centre, Western Gateway Building, University College Cork, Cork, Ireland.
authors.forename: Sharon L
authors.initials: SL
authors.lastname: McKenna
authors.affiliation: Cardiothoracic Surgery Department, Cork University Hospital, Cork, Ireland.
authors.forename: Kishore K
authors.initials: KK
authors.lastname: Doddakula
authors.affiliation: Cork Cancer Research Centre, Western Gateway Building, University College Cork, Cork, Ireland; Department of Medical Oncology, Mercy University Hospital, Grenville Place, Cork, Ireland.
authors.forename: Derek G
authors.initials: DG
authors.lastname: Power
authors.affiliation: Cork Cancer Research Centre, Western Gateway Building, University College Cork, Cork, Ireland.
authors.forename: Declan M
authors.initials: DM
authors.lastname: Soden
authors.affiliation: Cork Cancer Research Centre, Western Gateway Building, University College Cork, Cork, Ireland. Electronic address: p.forde@ucc.ie.
authors.forename: Patrick F
authors.initials: PF
authors.lastname: Forde
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D004734:Energy Metabolism / Q000187:drug effects; D006019:Glycolysis / Q000187:drug effects*; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*; D053858:Metabolic Networks and Pathways / Q000187:drug effects; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology
chemical_list: D000255:Adenosine Triphosphate
keywords: Electroporation; Glycolysis; Glycolytic modulator; Immune-metabolic interaction