title: Three year functional changes and long-term mortality hazard in community-dwelling older men.
abstract: BACKGROUND
  Low levels of physical function have been associated with higher mortality hazard in older persons. However, few studies have investigated the association between functional changes and subsequent mortality. This study aimed to examine whether 3-year functional changes independently predict subsequent all-cause mortality.
  
  
  METHODS
  This population-based cohort study included 171 community-dwelling men aged ≥71years at wave 2 (baseline of the present analysis), living in the semi-rural community of Merelbeke (Belgium). Physical function assessments included the Short Form-36 (SF-36) Physical Function Index, Grip strength, Chair rising, and Timed Up and Go. Changes over a 3-year time were calculated using data obtained at four annual visits.
  
  
  RESULTS
  After a 15-year follow-up, 149 men (87%) died. Median survival time was 8.2 (4.2-12.4) years. Physical function assessed at a single time point (at wave 2 or wave 5) was significantly associated with subsequent mortality hazard, independently from future or preceding 3-year changes. Greater functional declines during the 3-year follow-up were associated with higher mortality hazards. These associations were 1) more pronounced within the first seven years, 2) independent from baseline age, polypharmacy, depression, disability, and physical function, and 3) no longer significant when closure physical function was taken into account.
  
  
  CONCLUSIONS
  Physical function assessed at a single time point is a robust predictor of all-cause long-term mortality in community-dwelling older men. Yet, repeated assessments of physical function can provide prognostic information beyond that available from single initial assessment. However, with repeated assessments, most prognostic information can be found in the final assessment of physical function.
authors.affiliation: Department of Geriatrics, Ghent University Hospital, De Pintelaan 185 1K2, Ghent, Belgium. Electronic address: Stefanie.DeBuyser@UGent.be.
authors.forename: Stefanie
authors.initials: S
authors.lastname: De Buyser
authors.affiliation: Department of Geriatrics, Ghent University Hospital, De Pintelaan 185 1K2, Ghent, Belgium. Electronic address: Mirko.Petrovic@UGent.be.
authors.forename: Mirko
authors.initials: M
authors.lastname: Petrovic
authors.affiliation: Department of Endocrinology and Unit for Osteoporosis and Metabolic Bone Diseases, Ghent University Hospital, De Pintelaan 185 9K12, Ghent, Belgium.
authors.forename: Youri
authors.initials: Y
authors.lastname: Taes
authors.affiliation: Department of Endocrinology and Unit for Osteoporosis and Metabolic Bone Diseases, Ghent University Hospital, De Pintelaan 185 9K12, Ghent, Belgium.
authors.forename: Kaatje
authors.initials: K
authors.lastname: Toye
authors.affiliation: Department of Endocrinology and Unit for Osteoporosis and Metabolic Bone Diseases, Ghent University Hospital, De Pintelaan 185 9K12, Ghent, Belgium.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Kaufman
authors.affiliation: Department of Endocrinology and Unit for Osteoporosis and Metabolic Bone Diseases, Ghent University Hospital, De Pintelaan 185 9K12, Ghent, Belgium.
authors.forename: Stefan
authors.initials: S
authors.lastname: Goemaere
authors.affiliation: Department of Endocrinology and Unit for Osteoporosis and Metabolic Bone Diseases, Ghent University Hospital, De Pintelaan 185 9K12, Ghent, Belgium.
authors.forename: Bruno
authors.initials: B
authors.lastname: Lapauw
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D001530:Belgium; D005500:Follow-Up Studies; D015577:Geriatric Assessment / Q000379:methods*; D006801:Humans; D008297:Male; D009026:Mortality; D019338:Polypharmacy; D011379:Prognosis; D016016:Proportional Hazards Models; D012424:Rural Population
keywords: Change in physical function; Community-dwelling older men; Functional decline; Mortality; Physical performance