title: Protective roles of polysaccharides from Ganoderma lucidum on bleomycin-induced pulmonary fibrosis in rats.
abstract: The purpose of this paper was to investigate the protective effects of polysaccharides from (PGL) Ganoderma lucidum on bleomycin-induced pulmonary fibrosis in rats. Our study demonstrated that treatment with PGL of 100-300mg/kg for 28 days led to significant reduction in the pulmonary index, inflammatory cell infiltration and collagen deposition in rats with bleomycin-induced pulmonary fibrosis, which was associated with increased levels of glutathione, glutathione peroxidase, catalase and superoxide dismutase and decreased contents of malondialdehyde and hydroxyproline in the lung. These results indicated that PGL played a positive protective role in the pulmonary fibrosis and its possible mechanism was to improve lung antioxidant ability.
authors.affiliation: Department of Respiratory Medicine, Xiangya Hospital of Central South University, Key Site of National Clinical Research Center for Respiratory Disease, Changsha 410008, PR China; Department of Respiratory Medicine, Huai'an Second People's Hospital, Huai'an 223002, Jiangsu, PR China.
authors.forename: Jianhui
authors.initials: J
authors.lastname: Chen
authors.affiliation: School of Chemical Engineering, Huaiyin Institute of Technology, Huai'an 223003, Jiangsu, PR China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Xinhua College, Sun Yat-sen University, Guangzhou 510520, Guangdong, PR China.
authors.forename: Lian
authors.initials: L
authors.lastname: He
authors.affiliation: Department of Respiratory Medicine, Huai'an Second People's Hospital, Huai'an 223002, Jiangsu, PR China.
authors.forename: Hairong
authors.initials: H
authors.lastname: Hao
authors.affiliation: Department of Respiratory Medicine, Huai'an First People's Hospital, Nanjing Medical University, Huai'an 223300, Jiangsu, PR China.
authors.forename: Baolan
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Respiratory Medicine, Huai'an Second People's Hospital, Huai'an 223002, Jiangsu, PR China.
authors.forename: Yulong
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Department of Respiratory Medicine, Xiangya Hospital of Central South University, Key Site of National Clinical Research Center for Respiratory Disease, Changsha 410008, PR China. Electronic address: cjh0517@sohu.com.
authors.forename: Chengping
authors.initials: C
authors.lastname: Hu
mesh_terms: D000818:Animals; D001761:Bleomycin; D001835:Body Weight / Q000187:drug effects; D002374:Catalase / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006909:Hydroxyproline / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D011134:Polysaccharides / Q000494:pharmacology / Q000627:therapeutic use*; D020011:Protective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D011658:Pulmonary Fibrosis / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D017207:Rats, Sprague-Dawley; D020940:Reishi / Q000737:chemistry*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D011134:Polysaccharides; D020011:Protective Agents; D001761:Bleomycin; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione; D006909:Hydroxyproline
keywords: Polysaccharides from Ganoderma lucidum; Protective role; Pulmonary fibrosis