title: Dendrimer-based magnetic iron oxide nanoparticles: their synthesis and biomedical applications.
abstract: Magnetic iron oxide nanoparticles (MIO NPs) bearing different appropriate surface modifications can be prepared using diverse physical and chemical methods. As an ideal macromolecule, dendrimers have attracted considerable attention because of their unique properties, including their three 3D architecture, monodispersity, highly branched macromolecular characteristics, and tunable terminal functionalities. These properties make dendrimers a powerful nanoplatform for the creation of functional organic and/or inorganic hybrid NPs, in particular dendrimer-based MIO NPs. Here, we report on recent advances in the preparation of dendrimer-based MIO NPs for different biomedical applications, such as magnetic resonance (MR) imaging, drug and gene delivery, and protein immobilization.
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China.
authors.forename: Wenjie
authors.initials: W
authors.lastname: Sun
authors.affiliation: Université Paris Descartes, PRES Sorbonne Paris Cité, CNRS UMR 860, Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologique, 45, Rue des Saints Pères, 75006 Paris, France.
authors.forename: Serge
authors.initials: S
authors.lastname: Mignani
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China. Electronic address: mwshen@dhu.edu.cn.
authors.forename: Mingwu
authors.initials: M
authors.lastname: Shen
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China. Electronic address: xshi@dhu.edu.cn.
authors.forename: Xiangyang
authors.initials: X
authors.lastname: Shi
mesh_terms: D000818:Animals; D050091:Dendrimers / Q000008:administration & dosage / Q000138:chemical synthesis; D005290:Ferric Compounds / Q000008:administration & dosage / Q000737:chemistry; D052203:Ferrosoferric Oxide / Q000008:administration & dosage / Q000737:chemistry; D006801:Humans; D060328:Magnetic Phenomena; D053768:Metal Nanoparticles / Q000008:administration & dosage / Q000737:chemistry
chemical_list: D050091:Dendrimers; D005290:Ferric Compounds; C000499:ferric oxide; D052203:Ferrosoferric Oxide