title: The anti-diabetic activity of oat β-d-glucan in streptozotocin-nicotinamide induced diabetic mice.
abstract: This study was initiated to investigate the mechanism by which oat β-d-glucan (OBG) can control blood sugar levels and improve hepatogenic glycometabolism in streptozotocin-nicotinamide induced mice. After administration of different concentrations and molecular weights of β-d-glucan by oral gavage for 28 days, the body weight, fasting blood glucose, serum insulin, hepatic glycogen, glucose kinase and glucose-6-phosphatase activity of the diabetic mice were measured. In comparison with a negative control group (saline), β-d-glucan, especially medium or high doses of high-molecular-weight β-d-glucan, had a strong hypoglycaemic effect in streptozotocin-nicotinamide-induced mice. The mechanism of this effect may be associated with the high viscosity of the solution, an increase in insulin secretion, a decline in insulin resistance, and especially an improvement in hepatogenic glycometabolism. Moreover, β-d-glucan also markedly repaired and improved the integrity of pancreatic islet β-cell and tissue structures.
authors.affiliation: State Key Laboratory of Food Science and Technology & School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. Electronic address: waitliumei@foxmail.com.
authors.forename: Mei
authors.initials: M
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Food Science and Technology & School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. Electronic address: chumenghen123@gmail.com.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Food Science and Technology & School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. Electronic address: zhanghui@jiangnan.edu.cn.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Food Science and Technology & School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. Electronic address: 615159020@qq.com.
authors.forename: Bo
authors.initials: B
authors.lastname: Hu
authors.affiliation: State Key Laboratory of Food Science and Technology & School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. Electronic address: nmrwl@yahoo.com.cn.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Food Science and Technology & School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. Electronic address: 576589831@qq.com.
authors.forename: Haifeng
authors.initials: H
authors.lastname: Qian
authors.affiliation: State Key Laboratory of Food Science and Technology & School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. Electronic address: 307957312@qq.com.
authors.forename: Xiguang
authors.initials: X
authors.lastname: Qi
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D004326:Drinking / Q000187:drug effects; D005215:Fasting / Q000097:blood; D005951:Glucose Tolerance Test; D006003:Glycogen / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D051379:Mice; D008970:Molecular Weight; D009536:Niacinamide / Q000494:pharmacology*; D010179:Pancreas / Q000187:drug effects / Q000473:pathology; D047071:beta-Glucans / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D008112:Liver Glycogen; D047071:beta-Glucans; D009536:Niacinamide; C067858:beta-glucan, (1-3)(1-4)-; D006003:Glycogen
keywords: Diabetes; Hepatogenic glycometabolism; β-d-glucan