title: Severe Achromobacter xylosoxidans infection and loss of sputum bacterial diversity in an adult patient with cystic fibrosis.
abstract: Achromobacter spp. are emerging pathogens in the lungs of patients with cystic fibrosis. We report the case of an adult patient with cystic fibrosis and chronic A. xylosoxidans infection who experienced rapid, progressive clinical deterioration. Metagenomic analysis of the sputum revealed that the airway microbiota was almost entirely dominated by A. xylosoxidans. We review the impact of this organism on lung function and the airway microbiome in cystic fibrosis, and discuss the potential for cross-infection between patients.
authors.affiliation: Oxford Adult Cystic Fibrosis Centre, Oxford University Hospitals NHS Foundation Trust; Nuffield Department of Medicine, University of Oxford. Electronic address: nick.talbot@dpag.ox.ac.uk.
authors.forename: Nick P
authors.initials: NP
authors.lastname: Talbot
authors.affiliation: Oxford Adult Cystic Fibrosis Centre, Oxford University Hospitals NHS Foundation Trust.
authors.forename: William G
authors.initials: WG
authors.lastname: Flight
mesh_terms: D042441:Achromobacter denitrificans / Q000472:pathogenicity*; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D003428:Cross Infection / Q000188:drug therapy* / Q000382:microbiology*; D003550:Cystic Fibrosis / Q000382:microbiology* / Q000601:surgery; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology*; D006801:Humans; D016040:Lung Transplantation; D008297:Male; D013183:Sputum / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents
keywords: Achromobacter xylosoxidans; Cross-infection; Cystic fibrosis; Sputum microbiome