title: Atypical epithelial hyperplasia of the breast: state of the art.
abstract: BACKGROUND
  Atypical epithelial hyperplasia (AEH) of the breast is considered benign histological lesions with breast cancer risk. This review focuses on clinical signification and management of AEH that remains controversial.
  
  
  METHODS
  A review of published studies was performed using medline database. In this review, we fully describe the current evidence available. In particular, we describe 1) data from immunohistochemistry and molecular studies that suggest AEH is a precursor of breast cancer; 2) epidemiological studies demonstrate low rate of breast cancer in women with AEH; 3) surgical excision is necessary after diagnosis of AEH, such as lobular carcinoma in situ or atypical ductal hyperplasia, on core needle biopsy; 4) although current recommendations are evolving to fewer (if not no) excisions for flat epithelial with atypia and classic lobular neoplasia found on percutaneous biopsy (without radiologic indications for excision). Expert commentary: HEA management steel need prospective evidences, but recent retrospective data give some clue for less invasive management for some of HEA.
authors.affiliation: a Department of Gynaecology , Rennes University Hospital , Rennes , Cedex 2 , France.
authors.forename: Ludivine
authors.initials: L
authors.lastname: Dion
authors.affiliation: a Department of Gynaecology , Rennes University Hospital , Rennes , Cedex 2 , France.
authors.forename: Adelaïde
authors.initials: A
authors.lastname: Racin
authors.affiliation: a Department of Gynaecology , Rennes University Hospital , Rennes , Cedex 2 , France.
authors.forename: Susie
authors.initials: S
authors.lastname: Brousse
authors.affiliation: b Department of Tumour Pathology , Georges-François Leclerc Cancer Centre - Unicancer , Dijon , France.|c University of Burgundy-Franche Comté , Dijon , France.|d Department of Surgical Oncology , Georges-François Leclerc Cancer Centre - Unicancer , Dijon , France.
authors.forename: Françoise
authors.initials: F
authors.lastname: Beltjens
authors.affiliation: e Department of Tumour Pathology , Rennes University Hospital, University of Rennes 1 , Rennes , France.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Cauchois
authors.affiliation: a Department of Gynaecology , Rennes University Hospital , Rennes , Cedex 2 , France.|f Regional University Centre of Mastology, CRLCC Eugène Marquis , Rennes , Cedex , France.|g ER440, Oncogenesis, Stress and Signaling , INSERM , Rennes , France.
authors.forename: Jean
authors.initials: J
authors.lastname: Levêque
authors.affiliation: b Department of Tumour Pathology , Georges-François Leclerc Cancer Centre - Unicancer , Dijon , France.|c University of Burgundy-Franche Comté , Dijon , France.|d Department of Surgical Oncology , Georges-François Leclerc Cancer Centre - Unicancer , Dijon , France.
authors.forename: Charles
authors.initials: C
authors.lastname: Coutant
authors.affiliation: a Department of Gynaecology , Rennes University Hospital , Rennes , Cedex 2 , France.|f Regional University Centre of Mastology, CRLCC Eugène Marquis , Rennes , Cedex , France.|g ER440, Oncogenesis, Stress and Signaling , INSERM , Rennes , France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Lavoué
mesh_terms: D001706:Biopsy; D001940:Breast / Q000473:pathology* / Q000601:surgery; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000175:diagnosis / Q000473:pathology; D007150:Immunohistochemistry; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D012306:Risk
keywords: Atypical ductal hyperplasia; atypical lobular hyperplasia; breast cancer; columnar cell lesions with atypia; core needle biopsy; lobular carcinoma in situ; lobular neoplasia; surgical excision