title: Qualitative analysis of major constituents from Xue Fu Zhu Yu Decoction using ultra high performance liquid chromatography with hybrid ion trap time-of-flight mass spectrometry.
abstract: Xue Fu Zhu Yu Decoction, a famous formula that has been used for treating many blood stasis-caused diseases for many centuries, comprises 11 kinds of traditional Chinese medicines. A convenient, efficient, and rapid analytical method was developed to simultaneously determine the major compounds in this decoction. An ultra-high performance liquid chromatography with hybrid ion trap time-of-flight mass spectrometry method was used to rapidly separate and detect the major constituents of the decoction. Using this technique, we identified or tentatively identified 34 compounds, including 21 flavonoids, 5 terpenoids, 3 organic acids, 2 lactones, 1 alkaloid, 1 amino acid, and 1 cyanogenic glycoside. The MS analysis of these constituents was described in detail. Findings may contribute to future metabolic and pharmacokinetic studies of this medicine.
authors.affiliation: College of Chemistry and Chemical Engineering, Central South University, Hunan, Changsha, P. R. China.|Department of Pharmacy, Shaoyang Medical College Level Specialty School, Hunan, Shaoyang, P. R. China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Fu
authors.affiliation: Laboratory of Ethnopharmacology, Institute of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Hunan, Changsha, P. R. China.
authors.forename: Zian
authors.initials: Z
authors.lastname: Xia
authors.affiliation: Department of Pharmacy, Shaoyang Medical College Level Specialty School, Hunan, Shaoyang, P. R. China.
authors.forename: Yonghui
authors.initials: Y
authors.lastname: Liu
authors.affiliation: College of Chemistry and Chemical Engineering, Central South University, Hunan, Changsha, P. R. China. hongmeilu@csu.edu.cn.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Lu
authors.affiliation: College of Chemistry and Chemical Engineering, Central South University, Hunan, Changsha, P. R. China.
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Laboratory of Ethnopharmacology, Institute of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Hunan, Changsha, P. R. China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: College of Chemistry and Chemical Engineering, Central South University, Hunan, Changsha, P. R. China.
authors.forename: Xiaqiong
authors.initials: X
authors.lastname: Fan
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D013058:Mass Spectrometry / Q000379:methods*; D008516:Medicine, Chinese Traditional; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal; C513826:Xue-Fu-Zhu-Yu decoction
keywords: Major constituents; Qualitative analysis; Traditional Chinese medicine; Ultra-high performance liquid chromatography; Xue Fu Zhu Yu Decoction