title: Chemical exchange saturation transfer (CEST) imaging with fast variably-accelerated sensitivity encoding (vSENSE).
abstract: The widespread clinical use of chemical exchange saturation transfer (CEST) imaging is hampered by relatively long scan times due to its requirement that multiple saturation-offset image frames be acquired. Here, a novel variably-accelerated sensitivity encoding (vSENSE) method is proposed that provides faster CEST acquisition than conventional SENSE.
  
  
  
  The vSENSE method fully samples one CEST saturation frame, then undersamples the other frames variably. The fully-sampled frame, in conjunction with newly proposed incoherence absorption and artifact suppression strategies, improves the accuracy of sensitivity maps and permits higher acceleration factors for the other undersampled frames than regular SENSE. vSENSE is validated in a phantom, a normal volunteer and eight brain tumor patients at 3 Tesla.
  
  
  
  vSENSE with an acceleration factor of four generated a 3-6 times smaller error on average than conventional SENSE (P ≤ 0.02), with acceleration factors of 2-4, as compared with full k-space reconstruction. vSENSE permitted four-fold acceleration for amide proton transfer-weighted images, while regular SENSE could only provide a factor of two. When conventional SENSE is used with vSENSE's variable undersampling pattern, erroneous (∼9%) z-spectra result.
  
  
  
  The vSENSE method enabled twice the acceleration and generated more accurate images than conventional SENSE. Magn Reson Med 77:2225-2238, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
authors.affiliation: Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland, USA.
authors.forename: Yi
authors.identifier: 0000-0001-8738-1851
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland, USA.|F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA.
authors.forename: Hye-Young
authors.initials: HY
authors.lastname: Heo
authors.affiliation: Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland, USA.
authors.forename: Dong-Hoon
authors.initials: DH
authors.lastname: Lee
authors.affiliation: Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland, USA.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Jiang
authors.affiliation: Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland, USA.
authors.forename: Xuna
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland, USA.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Bottomley
authors.affiliation: Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland, USA.|F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA.
authors.forename: Jinyuan
authors.initials: J
authors.lastname: Zhou
mesh_terms: D000465:Algorithms; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D057054:Molecular Imaging / Q000379:methods*; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted
keywords: amide proton transfer (APT); brain tumor; chemical exchange saturation transfer (CEST); sensitivity encoding (SENSE); variably-accelerated sensitivity encoding (vSENSE)