title: Uncoupling proteins of invertebrates: A review.
abstract: Uncoupling proteins (UCPs) mediate inducible proton conductance in the mitochondrial inner membrane. Herein, we summarize our knowledge regarding UCPs in invertebrates. Since 2001, the presence of UCPs has been demonstrated in nematodes, mollusks, amphioxi, and insects. We discuss the following important issues concerning invertebrate UCPs: their evolutionary relationships, molecular and functional properties, and physiological impact. Evolutionary analysis indicates that the branch of vertebrate and invertebrate UCP4-5 diverged early in the evolutionary process prior to the divergence of the animal groups. Several proposed physiological roles of invertebrate UCPs are energy control, metabolic balance, and preventive action against oxidative stress. © 2016 IUBMB Life, 68(9):691-699, 2016.
authors.affiliation: Department of Animal Physiology and Development, Adam Mickiewicz University, Poznan, Poland.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Slocinska
authors.affiliation: Department of Molecular Virusology, Adam Mickiewicz University, Poznan, Poland.
authors.forename: Jakub
authors.initials: J
authors.lastname: Barylski
authors.affiliation: Department of Bioenergetics, Faculty of Biology, Adam Mickiewicz University, Poznan, Poland.
authors.forename: Wieslawa
authors.initials: W
authors.lastname: Jarmuszkiewicz
mesh_terms: D000595:Amino Acid Sequence / Q000235:genetics; D000818:Animals; D007448:Invertebrates / Q000235:genetics* / Q000378:metabolism; D051336:Mitochondrial Membranes / Q000378:metabolism*; D000071245:Mitochondrial Uncoupling Proteins / Q000235:genetics* / Q000378:metabolism; D018384:Oxidative Stress / Q000235:genetics; D010802:Phylogeny
chemical_list: D000071245:Mitochondrial Uncoupling Proteins
keywords: energy dissipation; insects; invertebrates; mitochondria; uncoupling proteins