title: Therapeutic Effectiveness of Anticancer Phytochemicals on Cancer Stem Cells.
abstract: Understanding how to target cancer stem cells (CSCs) may provide helpful insights for the development of therapeutic or preventive strategies against cancers. Dietary phytochemicals with anticancer properties are promising candidates and have selective impact on CSCs. This review summarizes the influence of phytochemicals on heterogeneous cancer cell populations as well as on specific targeting of CSCs.
authors.affiliation: School of Food Science and Biotechnology (BK21 Plus), Kyungpook National University, Daegu 41566, Korea. j.oh@knu.ac.kr.
authors.forename: Jisun
authors.initials: J
authors.lastname: Oh
authors.affiliation: Center of Cancer Systems Biology, Tufts University School of Medicine, Boston, MA 02135, USA. hlatky@cancer-systems-biology.org.
authors.forename: Lynn
authors.initials: L
authors.lastname: Hlatky
authors.affiliation: Department of Food Science and Technology, Chonbuk National University, Jeonju 54896, Korea. ysjeong@jbnu.ac.kr.
authors.forename: Yong-Seob
authors.initials: YS
authors.lastname: Jeong
authors.affiliation: Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, Boston, MA 02111, USA. dohoon.kim@tufts.edu.
authors.forename: Dohoon
authors.initials: D
authors.lastname: Kim
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000378:metabolism; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D014411:Neoplastic Stem Cells / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D010641:Phenotype; D064209:Phytochemicals / Q000627:therapeutic use*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014408:Biomarkers, Tumor; D064209:Phytochemicals
keywords: anticancer; cancer; cancer stem cells; phytochemicals; polyphenols