title: Mycophenolate Mofetil for the Treatment of Multiple Sclerosis-associated Uveitis.
abstract: OBJECTIVE
  To report the efficacy of mycophenolate mofetil (MMF) as adjunctive therapy for the treatment of multiple sclerosis (MS)-associated uveitis.
  
  
  METHODS
  In this retrospective, interventional case series, patients with MS-associated uveitis who were treated by MMF as an adjunct therapy to systemic corticosteroid were studied. Patients' demographics, clinical course, response to treatment, and complications were assessed.
  
  
  RESULTS
  A total of 30 eyes of 15 patients with a mean age of 34.5 ± 8.3 years were studied. In three patients (20%), onset of uveitis preceded the diagnosis of MS. The course of MS was relapsing-remitting in 11 patients (73.3%) and secondary progressive in four patients (26.7%). At 1 year after institution of MMF, all the patients were on oral prednisolone ≤ 7.5 mg/day, all eyes were quiet without macular edema, and 53.3% of eyes gained visual improvement. Supplemental periocular and intraocular injections were needed during the first 6 months after starting MMF therapy. The systemic adverse effects were transient and minor in severity.
  
  
  CONCLUSIONS
  MMF had beneficial effects on vision and intraocular inflammation with an acceptable safety profile.
authors.affiliation: a Noor Ophthalmic Research Center , Noor Eye Hospital , Tehran , Iran.|b Eye Research Center, Rassoul Akram Hospital , Iran University of Medical Sciences , Tehran , Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Hedayatfar
authors.affiliation: b Eye Research Center, Rassoul Akram Hospital , Iran University of Medical Sciences , Tehran , Iran.
authors.forename: Khalil Ghasemi
authors.initials: KG
authors.lastname: Falavarjani
authors.affiliation: c Ophthalmic Research Center, Labbafinejad Medical Center , Shahid Beheshti Medical University , Tehran , Iran.
authors.forename: Masoud
authors.initials: M
authors.lastname: Soheilian
authors.affiliation: b Eye Research Center, Rassoul Akram Hospital , Iran University of Medical Sciences , Tehran , Iran.
authors.forename: Navid
authors.initials: N
authors.lastname: Elmi Sadr
authors.affiliation: b Eye Research Center, Rassoul Akram Hospital , Iran University of Medical Sciences , Tehran , Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Modarres
authors.affiliation: b Eye Research Center, Rassoul Akram Hospital , Iran University of Medical Sciences , Tehran , Iran.
authors.forename: Mohammad Mehdi
authors.initials: MM
authors.lastname: Parvaresh
authors.affiliation: b Eye Research Center, Rassoul Akram Hospital , Iran University of Medical Sciences , Tehran , Iran.
authors.forename: Masood
authors.initials: M
authors.lastname: Naseripour
authors.affiliation: d Department of Neurology, Rassoul Akram Hospital , Iran University of Medical Sciences , Tehran , Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Rohani
authors.affiliation: d Department of Neurology, Rassoul Akram Hospital , Iran University of Medical Sciences , Tehran , Iran.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Almasi
authors.affiliation: e Singapore National Eye Centre , Singapore.|f Singapore Eye Research Institute , Singapore.|g Department of Ophthalmology, Yong Loo Lin School of Medicine , National University of Singapore , Singapore.|h Duke-NUS Graduate Medical School , Singapore.
authors.forename: Soon-Phaik
authors.initials: SP
authors.lastname: Chee
mesh_terms: D000293:Adolescent; D000328:Adult; D017024:Chemotherapy, Adjuvant; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D005260:Female; D005451:Fluorescein Angiography; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000503:physiopathology; D009173:Mycophenolic Acid / Q000627:therapeutic use*; D011239:Prednisolone / Q000627:therapeutic use; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D014605:Uveitis / Q000188:drug therapy* / Q000503:physiopathology; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult
chemical_list: D004791:Enzyme Inhibitors; D005938:Glucocorticoids; D011239:Prednisolone; D009173:Mycophenolic Acid
keywords: Multiple sclerosis; mycophenolate mofetil; uveitis