title: Photorefractive keratectomy combined with corneal wavefront-guided and hyperaspheric ablation profiles to correct myopia.
abstract: To evaluate the effects of photorefractive keratectomy (PRK) combined with corneal wavefront-guided ablation profiles and hyperaspheric ablation profiles on changes in higher-order aberrations (HOAs).
  
  
  
  Yonsei University College of Medicine and Eyereum Clinic, Seoul, South Korea.
  
  
  
  Comparative observational case series.
  
  
  
  Medical records of patients who had corneal wavefront-guided hyperaspheric PRK, corneal wavefront-guided mild-aspheric PRK, or non-corneal wavefront-guided mild-aspheric PRK were analyzed. The logMAR uncorrected distance visual acuity (UDVA), manifest refraction spherical equivalent (MRSE), and changes in corneal aberrations (root-mean-square [RMS] HOAs, spherical aberration, coma) were evaluated 1, 3, and 6 months postoperatively.
  
  
  
  The records of 61 patients (96 eyes) were reviewed. There was no statistically significant difference in logMAR UDVA or MRSE between the 3 groups at any timepoint. Corneal RMS HOAs were significantly smaller in the corneal wavefront-guided hyperaspheric group and the corneal wavefront-guided mild-aspheric group than in the noncorneal wavefront-guided mild-aspheric group at each timepoint. Corneal spherical aberration was significantly smaller for corneal wavefront-guided hyperaspheric PRK than for noncorneal wavefront-guided mild-aspheric PRK 6 months postoperatively. Changes in corneal spherical aberration (preoperatively and 6 months postoperatively) in corneal wavefront-guided hyperaspheric PRK were significantly smaller than in corneal wavefront-guided mild-aspheric PRK (P = .046). Corneal coma was significantly smaller with corneal wavefront-guided hyperaspheric PRK and corneal wavefront-guided mild-aspheric PRK than with noncorneal wavefront-guided mild-aspheric PRK 3 months and 6 months postoperatively.
  
  
  
  Corneal wavefront-guided hyperaspheric PRK induced less corneal spherical aberration 6 months postoperatively than corneal wavefront-guided mild-aspheric PRK and noncorneal wavefront-guided mild-aspheric PRK.
  
  
  
  None of the authors has a financial or proprietary interest in any material or method mentioned.
authors.affiliation: From the Department of Ophthalmology (Lee), International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon, and the Institute of Vision Research (Lee, Park, E.K. Kim, Seo, T-i. Kim), the Department of Ophthalmology, Yonsei University College of Medicine, Eyereum Eye Clinic (Kang, Ha, Choi), and the Corneal Dystrophy Research Institute (E.K. Kim), Severance Biomedical Science Institute, and Brain Korea 21 Plus Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: Hun
authors.initials: H
authors.lastname: Lee
authors.affiliation: From the Department of Ophthalmology (Lee), International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon, and the Institute of Vision Research (Lee, Park, E.K. Kim, Seo, T-i. Kim), the Department of Ophthalmology, Yonsei University College of Medicine, Eyereum Eye Clinic (Kang, Ha, Choi), and the Corneal Dystrophy Research Institute (E.K. Kim), Severance Biomedical Science Institute, and Brain Korea 21 Plus Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: Si Yoon
authors.initials: SY
authors.lastname: Park
authors.affiliation: From the Department of Ophthalmology (Lee), International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon, and the Institute of Vision Research (Lee, Park, E.K. Kim, Seo, T-i. Kim), the Department of Ophthalmology, Yonsei University College of Medicine, Eyereum Eye Clinic (Kang, Ha, Choi), and the Corneal Dystrophy Research Institute (E.K. Kim), Severance Biomedical Science Institute, and Brain Korea 21 Plus Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: David Sung
authors.initials: DS
authors.lastname: Yong Kang
authors.affiliation: From the Department of Ophthalmology (Lee), International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon, and the Institute of Vision Research (Lee, Park, E.K. Kim, Seo, T-i. Kim), the Department of Ophthalmology, Yonsei University College of Medicine, Eyereum Eye Clinic (Kang, Ha, Choi), and the Corneal Dystrophy Research Institute (E.K. Kim), Severance Biomedical Science Institute, and Brain Korea 21 Plus Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: Byoung Jin
authors.initials: BJ
authors.lastname: Ha
authors.affiliation: From the Department of Ophthalmology (Lee), International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon, and the Institute of Vision Research (Lee, Park, E.K. Kim, Seo, T-i. Kim), the Department of Ophthalmology, Yonsei University College of Medicine, Eyereum Eye Clinic (Kang, Ha, Choi), and the Corneal Dystrophy Research Institute (E.K. Kim), Severance Biomedical Science Institute, and Brain Korea 21 Plus Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: Jin Young
authors.initials: JY
authors.lastname: Choi
authors.affiliation: From the Department of Ophthalmology (Lee), International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon, and the Institute of Vision Research (Lee, Park, E.K. Kim, Seo, T-i. Kim), the Department of Ophthalmology, Yonsei University College of Medicine, Eyereum Eye Clinic (Kang, Ha, Choi), and the Corneal Dystrophy Research Institute (E.K. Kim), Severance Biomedical Science Institute, and Brain Korea 21 Plus Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: Eung Kweon
authors.initials: EK
authors.lastname: Kim
authors.affiliation: From the Department of Ophthalmology (Lee), International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon, and the Institute of Vision Research (Lee, Park, E.K. Kim, Seo, T-i. Kim), the Department of Ophthalmology, Yonsei University College of Medicine, Eyereum Eye Clinic (Kang, Ha, Choi), and the Corneal Dystrophy Research Institute (E.K. Kim), Severance Biomedical Science Institute, and Brain Korea 21 Plus Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: Kyoung Yul
authors.initials: KY
authors.lastname: Seo
authors.affiliation: From the Department of Ophthalmology (Lee), International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon, and the Institute of Vision Research (Lee, Park, E.K. Kim, Seo, T-i. Kim), the Department of Ophthalmology, Yonsei University College of Medicine, Eyereum Eye Clinic (Kang, Ha, Choi), and the Corneal Dystrophy Research Institute (E.K. Kim), Severance Biomedical Science Institute, and Brain Korea 21 Plus Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea. Electronic address: tikim@yuhs.ac.
authors.forename: Tae-Im
authors.initials: TI
authors.lastname: Kim
mesh_terms: D019781:Corneal Topography; D057108:Corneal Wavefront Aberration; D006801:Humans; D000074431:Keratectomy; D054018:Lasers, Excimer; D009216:Myopia / Q000628:therapy*; D018903:Photorefractive Keratectomy; D011446:Prospective Studies; D012029:Refraction, Ocular; D056910:Republic of Korea