title: Prominent Anti-UV Activity and Possible Cosmetic Potential of Lignin-carbohydrate Complex.
abstract: This review article summarizes the recent progress of ultraviolet rays (UV) protective substances, including our original reports. We have established a simple assay method for the determination of anti-UV activity that can be applicable to any kind of adherent cells. This method provides information of both anti-UV activity and cytotoxicity of any kind of samples even though those samples contain unknown amounts of test compounds. We found that lignin-carbohydrate complex (LCC) showed one- or two-order higher anti-UV activity compared to well-known lower molecular weight polyphenols and hot-water extracts of Kampo medicines and tea leaves. Among synthetic compounds, water-soluble azulenes showed the highest anti-UV activity. LCC showed additive or synergistic anti-UV activity with vitamin C. Alkaline extract of Sasa senanensis Rehder leaves (SE), an LCC-rich over-the-counter (OTC) drug, also showed potent antiviral and vitamin C-synergized radical scavenging activity. SE has been utilized to manufacture tooth paste, soap and gel cosmetic to increase the level of quality of life (QOL).
authors.affiliation: Division of Pharmacology, Meikai University School of Dentistry, Sakado, Japan Meikai Pharmaco-Medical Laboratory (MPL), Meikai University School of Dentistry, Sakado, Japan sakagami@dent.meikai.ac.jp takaakio@daiwaseibutsu.co.jp.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sakagami
authors.affiliation: Meikai Pharmaco-Medical Laboratory (MPL), Meikai University School of Dentistry, Sakado, Japan.
authors.forename: Hong
authors.initials: H
authors.lastname: Sheng
authors.affiliation: Division of Pharmacology, Meikai University School of Dentistry, Sakado, Japan.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Okudaira
authors.affiliation: Division of Oral Health, Meikai University School of Dentistry, Sakado, Japan.
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Yasui
authors.affiliation: Faculty of Science, Josai University, Sakado, Japan.
authors.forename: Hidetsugu
authors.initials: H
authors.lastname: Wakabayashi
authors.affiliation: Daiwa Biological Research Institute Co., Ltd., Kanagawa, Japan.
authors.forename: Junye
authors.initials: J
authors.lastname: Jia
authors.affiliation: Daiwa Biological Research Institute Co., Ltd., Kanagawa, Japan.
authors.forename: Takenori
authors.initials: T
authors.lastname: Natori
authors.affiliation: Daiwa Biological Research Institute Co., Ltd., Kanagawa, Japan.
authors.forename: Madoka
authors.initials: M
authors.lastname: Suguro-Kitajima
authors.affiliation: Daiwa Biological Research Institute Co., Ltd., Kanagawa, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Oizumi
authors.affiliation: Daiwa Biological Research Institute Co., Ltd., Kanagawa, Japan.
authors.forename: Takaaki
authors.initials: T
authors.lastname: Oizumi
mesh_terms: D002241:Carbohydrates / Q000737:chemistry / Q000494:pharmacology*; D003358:Cosmetics; D006801:Humans; D008031:Lignin / Q000737:chemistry / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000737:chemistry / Q000494:pharmacology*; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D002241:Carbohydrates; D003358:Cosmetics; D011837:Radiation-Protective Agents; D008031:Lignin
keywords: UV protection; assay system; lignin-carbohydrate complex; review