title: Antiviral potential of a diterpenoid compound sugiol from Metasequoia glyptostroboides.
abstract: This research reports first time antiviral activity of sugiol, a diterpenoid isolated from Metasequoia glyptostroboides in terms of its ability to inhibit in vitro growth of H1N1 influenza virus. Antiviral potential of sugiol was evaluated through hcytopathogenic reduction assay using Madin-Darby canine kidney (MDCK) cell line. Sugiol (500 μg/ml) was found to exhibit considerable anti-cytopathic effect on MDCK cell line confirming its antiviral efficacy against H1N1 influenza virus. These findings strongly reinforce the suggestion that sugiol could be a candidate of choice in combinational regimen with potential antiviral efficacy.
authors.affiliation: Department of Applied Microbiology and Biotechnology, School of Biotechnology, Yeungnam University, Gyeongsan, Korea.
authors.forename: Vivek K
authors.initials: VK
authors.lastname: Bajpai
authors.affiliation: Department of Oriental Pharmacy, Wonkwang University, Iksan-city, Jeonbuk, Korea.
authors.forename: Na-Hyung
authors.initials: NH
authors.lastname: Kim
authors.affiliation: Division of Biotechnology, College of Environmental and Bioresource Sciences, Chonbuk National University, Gobong-ro, Iksan-si, Joellabuk-do (Jeonbuk), Korea.
authors.forename: Kangmin
authors.initials: K
authors.lastname: Kim
authors.affiliation: Department of Biotechnology, College of Engineering, Daegu University, Gyeongsan, Gyeongbuk, Korea.
authors.forename: Sun Chul
authors.initials: SC
authors.lastname: Kang
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology*; D029779:Cupressaceae / Q000737:chemistry; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D004285:Dogs; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects* / Q000254:growth & development / Q000472:pathogenicity; D061985:Madin Darby Canine Kidney Cells; D008517:Phytotherapy; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal
chemical_list: D000998:Antiviral Agents; D004224:Diterpenes; D010936:Plant Extracts; C501333:sugiol