title: Reactivation of Human Herpes Virus-6 in the Renal Tissue of a Patient with Drug-induced Hypersensitivity Syndrome/Drug Rash with Eosinophilia and Systemic Symptoms (DIHS/DRESS).
abstract: A 74-year-old man who had been administered trimethoprim-sulfamethoxazole for three weeks suffered from drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms (DIHS/DRESS). In the early stage of the clinical course, he developed renal dysfunction. A renal biopsy showed granulomatous tubulointerstitial nephritis accompanying the proliferation of human herpes virus (HHV)-6 in tubular epithelial cells. With corticosteroid therapy, the systemic rash and renal function gradually improved. The present patient is the second case of DIHS/DRESS demonstrating a possible reactivation of HHV-6 in the renal tissue. The clinical role of viral reactivation in DIHS/DRESS must be further elucidated.
authors.affiliation: Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
authors.forename: Hideharu
authors.initials: H
authors.lastname: Hagiya
authors.forename: Masaya
authors.initials: M
authors.lastname: Iwamuro
authors.forename: Takehiro
authors.initials: T
authors.lastname: Tanaka
authors.forename: Kou
authors.initials: K
authors.lastname: Hasegawa
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Hanayama
authors.forename: Maya
authors.initials: M
authors.lastname: Kimura
authors.forename: Fumio
authors.initials: F
authors.lastname: Otsuka
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D063926:Drug Hypersensitivity Syndrome / Q000150:complications* / Q000188:drug therapy / Q000209:etiology; D004802:Eosinophilia / Q000150:complications*; D015654:Herpesvirus 6, Human / Q000502:physiology*; D006801:Humans; D008297:Male; D051437:Renal Insufficiency / Q000150:complications* / Q000821:virology*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects
chemical_list: D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination