title: B-Cell Depletion Salvage Therapy in Rapidly Progressive Dermatomyositis Related Interstitial Lung Disease.
abstract: Interstitial lung disease (ILD) is a major cause of morbidity and mortality in patients with idiopathic inflammatory myopathies (IIM). Glucocorticoids are the initial standard treatment. However, many patients fail to respond and continue to progress despite treatment with high dose glucocorticoids. The efficacy of rituximab has been suggested in case reports and case series of refractory antisynthetase (AS) syndrome, but data on patients without auto-antibodies or with rapidly progressive ILD are scarce. We report a case of rapidly progressive dermatomyositis (DM) associated ILD treated successfully with B-cell depletion therapy.
authors.affiliation: Fellow, Section of Pulmonary Diseases Critical Care and Environmental Medicine at Tulane University Health Sciences Center.
authors.forename: Khaled
authors.initials: K
authors.lastname: Eissa
authors.affiliation: Assistant Professor and Director Pulmonary and Critical Care Medicine Fellowship Program.
authors.forename: Jaime
authors.initials: J
authors.lastname: Palomino
mesh_terms: D000368:Aged; D001402:B-Lymphocytes / Q000187:drug effects*; D003882:Dermatomyositis / Q000188:drug therapy*; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage*; D017563:Lung Diseases, Interstitial / Q000150:complications*; D008297:Male; D000069283:Rituximab / Q000008:administration & dosage*; D016879:Salvage Therapy; D014057:Tomography, X-Ray Computed
chemical_list: D007155:Immunologic Factors; D000069283:Rituximab