title: Penicillin-induced liver injury during treatment for ocular neurosyphilis.
abstract: A 51-year-old man, homosexual, recently diagnosed with ocular neurosyphilis, presented to the emergency room with a 1-day history of fevers and chills. His vital signs were significant for a temperature of 102.8°F and tachycardia of 125 bpm. The patient had experienced blurred vision in his left eye and was diagnosed with ocular neurosyphilis 10 days prior to the current presentation. He was treated with a 14-day course of high-dose intravenous penicillin and oral prednisone. His laboratory studies were significant for transaminitis, with an aspartate aminotransferase of 1826 U/L, alanine aminotransferase of 1743 U/L, total bilirubin of 1.2 mg/dL and alkaline phosphatase of 68 U/L. After ruling out viral aetiologies and toxin-induced hepatic injury, penicillin was discontinued on the day following admission and transaminases promptly improved with resolution of symptoms. The patient's vision returned to normal within 2 weeks after discharge from hospital.
authors.affiliation: Royal College of Surgeons in Ireland, Dublin, Ireland.
authors.forename: Janelle
authors.initials: J
authors.lastname: Wilkinson
authors.affiliation: Department of Medicine, Galway University Hospital, Galway, Ireland.
authors.forename: Abir
authors.initials: A
authors.lastname: Zainal
authors.affiliation: Internal Medicine, Pennsylvania Hospital, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors.forename: Syed Yaseen
authors.initials: SY
authors.lastname: Naqvi
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D005128:Eye Diseases / Q000188:drug therapy* / Q000382:microbiology*; D006801:Humans; D008099:Liver / Q000187:drug effects; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D009494:Neurosyphilis / Q000188:drug therapy*; D010406:Penicillins / Q000009:adverse effects*
chemical_list: D000900:Anti-Bacterial Agents; D010406:Penicillins