title: A Subtrochanteric Femoral Stress Fracture following Bisphosphonate Treatment in an Adolescent Girl.
abstract: Atypical subtrochanteric and diaphyseal femoral fractures (AFFs) have emerged as a potential complication of bisphosphonate treatment in adults. Despite increasing off-label use of bisphosphonates in children and adolescents for a variety of skeletal disorders, there have been no reports of AFFs in children or adolescents outside of the osteogenesis imperfecta population. We present the case of a 16-year-old girl who developed a subtrochanteric femoral stress fracture following pamidronate treatment for idiopathic juvenile osteoporosis.
authors.affiliation: Section on Skeletal Disorders and Mineral Homeostasis, Craniofacial and Skeletal Diseases Branch, NIDCR, NIH, Bethesda, Md., USA.
authors.forename: Alison M
authors.initials: AM
authors.lastname: Boyce
authors.forename: Michael T
authors.initials: MT
authors.lastname: Collins
authors.forename: Laura L
authors.initials: LL
authors.lastname: Tosi
authors.forename: Rachel I
authors.initials: RI
authors.lastname: Gafni
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D004164:Diphosphonates / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D015775:Fractures, Stress / Q000139:chemically induced*; D006620:Hip Fractures / Q000139:chemically induced*; D006801:Humans; D010024:Osteoporosis / Q000188:drug therapy*; D000077268:Pamidronate
chemical_list: D004164:Diphosphonates; D000077268:Pamidronate