title: Loss of CD30 Expression in Anaplastic Large Cell Lymphoma Following Brentuximab Therapy.
abstract: Monoclonal antibody therapy is a new innovation in cancer therapy. Binding of monoclonal antibodies to tumor cells facilitates their destruction by the immune system. Tumor cells with mutated target antigens may escape detection by monoclonal antibodies and exhibit a selective growth advantage. This phenomenon was first recognized in CD20-negative B-cell lymphomas in patients previously treated with the anti-CD20 monoclonal antibody rituximab. We report a cutaneous recurrence of systemic ALCL with an anomalous CD30-negative immunophenotype. The patient had been previously treated with the anti-CD30 monoclonal antibody brentuximab. To our knowledge, we present the first reported case of a cutaneous recurrence of systemic ALCL with an anomalous CD30-negative immunophenotype following chronic brentuximab therapy. <br /><br /> <em>J Drugs Dermatol.</em> 2016;15(7):894-895.
authors.forename: Colton
authors.initials: C
authors.lastname: Nielson
authors.forename: Ryan
authors.initials: R
authors.lastname: Fischer
authors.forename: Garth
authors.initials: G
authors.lastname: Fraga
authors.forename: Daniel
authors.initials: D
authors.lastname: Aires
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D000079963:Brentuximab Vedotin; D005786:Gene Expression Regulation; D006801:Humans; D018796:Immunoconjugates / Q000009:adverse effects*; D017730:Ki-1 Antigen / Q000096:biosynthesis*; D017728:Lymphoma, Large-Cell, Anaplastic / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000139:chemically induced* / Q000175:diagnosis / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D018796:Immunoconjugates; D017730:Ki-1 Antigen; D000079963:Brentuximab Vedotin