title: Porous Silicon and Polymer Nanocomposites for Delivery of Peptide Nucleic Acids as Anti-MicroRNA Therapies.
abstract: Self-assembled polymer/porous silicon nanocomposites overcome intracellular and systemic barriers for in vivo application of peptide nucleic acid (PNA) anti-microRNA therapeutics. Porous silicon (PSi) is leveraged as a biodegradable scaffold with high drug-cargo-loading capacity. Functionalization with a diblock polymer improves PSi nanoparticle colloidal stability, in vivo pharmacokinetics, and intracellular bioavailability through endosomal escape, enabling PNA to inhibit miR-122 in vivo.
authors.affiliation: Interdisciplinary Graduate Program in Materials Science, Vanderbilt University, Nashville, TN, 37235, USA.
authors.forename: Kelsey R
authors.initials: KR
authors.lastname: Beavers
authors.affiliation: Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Werfel
authors.affiliation: Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
authors.forename: Tianwei
authors.initials: T
authors.lastname: Shen
authors.affiliation: Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
authors.forename: Taylor E
authors.initials: TE
authors.lastname: Kavanaugh
authors.affiliation: Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
authors.forename: Kameron V
authors.initials: KV
authors.lastname: Kilchrist
authors.affiliation: Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, 37235, USA.
authors.forename: Jeremy W
authors.initials: JW
authors.lastname: Mares
authors.affiliation: Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, 37235, USA.
authors.forename: Joshua S
authors.initials: JS
authors.lastname: Fain
authors.affiliation: Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, TN, 37235, USA.
authors.forename: Carrie B
authors.initials: CB
authors.lastname: Wiese
authors.affiliation: Department of Medicine/Division of Cardiovascular Medicine, Vanderbilt University, Nashville, TN, 37235, USA.
authors.forename: Kasey C
authors.initials: KC
authors.lastname: Vickers
authors.affiliation: Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, 37235, USA.
authors.forename: Sharon M
authors.initials: SM
authors.lastname: Weiss
authors.affiliation: Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA. craig.duvall@vanderbilt.edu.
authors.forename: Craig L
authors.initials: CL
authors.lastname: Duvall
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D003102:Colloids / Q000737:chemistry; D005260:Female; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000037:antagonists & inhibitors* / Q000235:genetics; D053761:Nanocomposites / Q000737:chemistry*; D020135:Peptide Nucleic Acids / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use*; D011108:Polymers / Q000737:chemistry*; D016062:Porosity; D000067492:RNAi Therapeutics; D012825:Silicon / Q000737:chemistry*
chemical_list: D003102:Colloids; C531907:MIRN122 microRNA, human; D035683:MicroRNAs; C544354:Mirn122 microRNA, mouse; D020135:Peptide Nucleic Acids; D011108:Polymers; D012825:Silicon
keywords: PNA; anti-miRNA; nanocomposite; peptide nucleic acids; porous silicon