title: New approaches and omics tools for mining of vaccine candidates against vector-borne diseases.
abstract: Vector-borne diseases (VBDs) present a major threat to human and animal health, as well as place a substantial burden on livestock production. As a way of sustainable VBD control, focus is set on vaccine development. Advances in genomics and other "omics" over the past two decades have given rise to a "third generation" of vaccines based on technologies such as reverse vaccinology, functional genomics, immunomics, structural vaccinology and the systems biology approach. The application of omics approaches is shortening the time required to develop the vaccines and increasing the probability of discovery of potential vaccine candidates. Herein, we review the development of new generation vaccines for VBDs, and discuss technological advancement and overall challenges in the vaccine development pipeline. Special emphasis is placed on the development of anti-tick vaccines that can quell both vectors and pathogens.
authors.affiliation: ERA Chair VetMedZg project, Internal Diseases Clinic, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, 10 000 Zagreb, Croatia. jkules@vef.hr.
authors.forename: Josipa
authors.initials: J
authors.lastname: Kuleš
authors.affiliation: ERA Chair VetMedZg project, Internal Diseases Clinic, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, 10 000 Zagreb, Croatia. jkules@vef.hr.
authors.forename: Anita
authors.initials: A
authors.lastname: Horvatić
authors.affiliation: ERA Chair VetMedZg project, Internal Diseases Clinic, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, 10 000 Zagreb, Croatia. jkules@vef.hr.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Guillemin
authors.affiliation: ERA Chair VetMedZg project, Internal Diseases Clinic, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, 10 000 Zagreb, Croatia. jkules@vef.hr.
authors.forename: Asier
authors.initials: A
authors.lastname: Galan
authors.affiliation: ERA Chair VetMedZg project, Internal Diseases Clinic, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, 10 000 Zagreb, Croatia. jkules@vef.hr.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Mrljak
authors.affiliation: ERA Chair VetMedZg project, Internal Diseases Clinic, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, 10 000 Zagreb, Croatia. jkules@vef.hr and Laboratory of Biomedical Microbiology and Immunology, Department of Microbiology and Immunology, University of Veterinary Medicine and Pharmacy, Kosice, Slovakia and Institute of Neuroimmunology, Slovakia Academy of Sciences, Bratislava, Slovakia.
authors.forename: Mangesh
authors.initials: M
authors.lastname: Bhide
mesh_terms: D000818:Animals; D001709:Biotechnology; D003140:Communicable Disease Control / Q000379:methods; D003141:Communicable Diseases / Q000209:etiology / Q000635:transmission*; D004199:Disease Vectors; D023281:Genomics / Q000379:methods; D006801:Humans; D014612:Vaccines / Q000235:genetics / Q000276:immunology
chemical_list: D014612:Vaccines