title: Pilomatrixoma of the breast in a patient with type 1 myotonic dystrophy: successful surgical approach.
abstract: Malherbes calcifying epithelioma is an uncommon cutaneous tumour that originates from the matrix cells of hair follicle. It was initially described by Malherbe as a benign calcifying epithelioma. Several ultra-structural and electron-microscopic studies later demonstrated its origin from matrix cells and the term pilomatrixoma was introduced. The treatment of this tumour remains mainly surgical. Malignant cases with post-surgical recurrences have been described in literature and recurrences have been related to an incomplete surgical treatment or tumour aggressiveness. We present the case of 31-year-old female patient with pilomatrixoma of the breast, which was very similar to fibroadenoma, in terms of size and other clinical features. We successfully treated this patient surgically, and the aesthetic results were good, despite the proximity of the tumour to the areola-nipple complex. Fifteen months later, the patient is doing well, free of any clinical local recurrence.
authors.affiliation: Department of Human Pathology; University Hospital of Messina, Messina, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Fama'
authors.affiliation: Department of Human Pathology; University Hospital of Messina, Messina, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Ieni
authors.affiliation: Medical Institute of Ministry of Interior (MVR-Sofia), Department of Dermatology, Venereology and Dermatologic Surgery, Sofia, Bulgaria.
authors.forename: G
authors.initials: G
authors.lastname: Tchernev
authors.affiliation: "Onkoderma"- Policlinic for Dermatology and Dermatologic Surgery, Sofia, Bulgaria; Department of Dermatology and Venereology, Medical University of Plovdiv, Medical Faculty, Plovdiv, Bulgaria.
authors.forename: A A
authors.initials: AA
authors.lastname: Chokoeva
authors.affiliation: Department Medicinal Information and Non-Interventional studies, Bulgarian Drug Agency, Sofia, Bulgaria.
authors.forename: G K
authors.initials: GK
authors.lastname: Maximov
authors.affiliation: Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Wollina
authors.affiliation: Department of Dermatology, University of Rome G. Marconi Rome, Italy.
authors.forename: T
authors.initials: T
authors.lastname: Lotti
authors.affiliation: University of Virginia Health System, Department of Pathology, Charlottesville, VA USA.
authors.forename: J W
authors.initials: JW
authors.lastname: Patterson
authors.affiliation: History Department, G. Marconi University, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Fioranelli
authors.affiliation: University B.I.S. Group of Institutions, Punjab Technical University, Punjab, India.
authors.forename: M G
authors.initials: MG
authors.lastname: Roccia
authors.affiliation: Department of Clinical and Experimental Medicine, Unit of Dermatology University Hospital of Messina, Messina, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Guarneri
authors.affiliation: Department of Human Pathology; University Hospital of Messina, Messina, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Gioffre-Florio
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D009223:Myotonic Dystrophy / Q000150:complications*; D018296:Pilomatrixoma / Q000150:complications* / Q000601:surgery*; D012878:Skin Neoplasms / Q000150:complications* / Q000601:surgery*