title: To compare anti-albumin urea effects of valsartan alone with combination of valsartan and amlodipine in patients of chronic kidney disease.
abstract: OBJECTIVE
  To compare anti-albumin urea effects of Valsartan alone with combination of Valsartan and Amlodipine in patients of chronic kidney disease.
  
  
  METHODS
  This randomized clinical trial was conducted at the Department of Medicine, Combined Military Hospital Bahawalpur, from April 2014 to 30 September 2014. 140 patients of chronic kidney disease with baseline blood pressure more than 140/90mm Hg having raised urinary albumin: creatinine ratio (UACR). UACR more than 3.5 mg/mmol was considered abnormal. Group-A was treated with Valsartan 80mg daily and Group-B was treated with valsartan 80 and amlodipine 10mg once a day. We did not change the dose of drugs and check spot UACR at base line and after six months with therapy and compare improvement in UACR between Group-A and B. Data was analyzed by statistical software packages (SPSS 16.0).
  
  
  RESULTS
  In both the groups, BP was significantly lower than the respective value. Mean decrease in spot UACR in Group-A was 3.18±2.64 mg/mmol and UACR in Group-B mean decrease in UACR was 13.01±20.11 mg/mmol. P value was< 0.05.
  
  
  CONCLUSIONS
  The combination therapy of valsartan with amlodipine significantly lowers the albuminuria in chronic Kidney disease and reduce the progression of disease as compared to Valsartan alone therapy.
authors.affiliation: Dr. Ameen, FCPS. Department of Medicine, Combine Military Hospital (CMH), Bahawalpur, Pakistan.
authors.lastname: Ameen
authors.affiliation: Dr. Muhammad Ali Kashif, FCPS. Department of Medicine, Combine Military Hospital (CMH), Bahawalpur, Pakistan.
authors.forename: Muhammad Ali
authors.initials: MA
authors.lastname: Kashif
authors.affiliation: Dr. Sumreen, M.Phil. Department of Pathology, SMBBMC, Department of Medicine, Combine Military Hospital (CMH), Bahawalpur, Pakistan.
authors.lastname: Sumreen
keywords: Albuminuria; Amlodipine; Spot urinary albumin: creatinine; Valsartan