title: Xenopus laevis Nkx5.3 and sensory organ homeobox (SOHo) are expressed in developing sensory organs and ganglia of the head and anterior trunk.
abstract: Nkx5 family members are homeobox transcription factors important for sensory organ development. Several members of the Nkx5 family are expressed in the eye, brain, developing ear, and lateral line. Members of this family have been previously identified in medaka, chick, and mouse. Here, we characterize two members of the Nkx5 family, Nkx5.3 and SOHo, in Xenopus laevis. We verify the identity of X. laevis Nkx5.3 and SOHo by phylogenetic comparison to chicken, medaka, and zebrafish orthologs. Both Nkx5.3 and SOHo are expressed in the developing eye, ear, lateral line system, and cranial neurons as determined by in situ hybridization.
authors.affiliation: Center for Molecular and Human Genetics, Nationwide Children's Hospital Research Institute, 700 Children's Drive, Columbus, OH, 43205, USA.
authors.forename: Lisa E
authors.initials: LE
authors.lastname: Kelly
authors.affiliation: Center for Molecular and Human Genetics, Nationwide Children's Hospital Research Institute, 700 Children's Drive, Columbus, OH, 43205, USA. Heithem.El-Hodiri@NationwideChildrens.org.|Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, OH, 43205, USA. Heithem.El-Hodiri@NationwideChildrens.org.
authors.forename: Heithem M
authors.initials: HM
authors.lastname: El-Hodiri
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D005724:Ganglia / Q000378:metabolism; D018398:Homeodomain Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D017403:In Situ Hybridization; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D010802:Phylogeny; D012679:Sense Organs / Q000254:growth & development* / Q000378:metabolism; D016415:Sequence Alignment; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D029867:Xenopus Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D014982:Xenopus laevis / Q000033:anatomy & histology / Q000254:growth & development* / Q000378:metabolism
chemical_list: C000621517:HMX1 protein, Xenopus; D018398:Homeodomain Proteins; D009419:Nerve Tissue Proteins; C000621516:SOHo protein, Xenopus; D014157:Transcription Factors; D029867:Xenopus Proteins
keywords: Cranial ganglia; Lateral line; Nkx5.3; Retina; Sensory organ homeobox; Xenopus laevis