title: Antibiotic Prophylaxis for Patients with a History of Total Joint Replacement.
abstract: As the population ages and people remain active into the 7th and 8th decades of life, the frequency of total joint replacement is increasing. Following joint replacement surgery, patients inevitably require various invasive procedures as part of their routine health maintenance, including, but not limited to, dental care, colonoscopy, cystoscopy, and cardiac catheterization. There is scant evidence to support the use of periprocedural prophylactic antibiotics in the prevention of late total joint infection. The guidelines for the usage of periprocedural antibiotics have changed as knowledge of the pathophysiology of joint infection has evolved. We review the current recommendations from subspecialty academic organizations regarding antibiotic prophylaxis for patients undergoing routine urologic, gastrointestinal, dental, and cardiac procedures after total joint replacement.
authors.affiliation: From the Department of Orthopaedics, Alpert Medical School, Brown University, Providence, RI (SFD, JAG, SR); the Department of Urology, University of Pennsylvania, Perelman Center for Advanced Medicine, Philadelphia (EL); and Department of Orthopaedics Alpert Medical School of Brown University, 593 Eddy Street, Providence, RI 02903 (KS). sdefroda@gmail.com.
authors.forename: Steven F
authors.initials: SF
authors.lastname: DeFroda
authors.affiliation: From the Department of Orthopaedics, Alpert Medical School, Brown University, Providence, RI (SFD, JAG, SR); the Department of Urology, University of Pennsylvania, Perelman Center for Advanced Medicine, Philadelphia (EL); and Department of Orthopaedics Alpert Medical School of Brown University, 593 Eddy Street, Providence, RI 02903 (KS).
authors.forename: Eliza
authors.initials: E
authors.lastname: Lamin
authors.affiliation: From the Department of Orthopaedics, Alpert Medical School, Brown University, Providence, RI (SFD, JAG, SR); the Department of Urology, University of Pennsylvania, Perelman Center for Advanced Medicine, Philadelphia (EL); and Department of Orthopaedics Alpert Medical School of Brown University, 593 Eddy Street, Providence, RI 02903 (KS).
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Gil
authors.affiliation: From the Department of Orthopaedics, Alpert Medical School, Brown University, Providence, RI (SFD, JAG, SR); the Department of Urology, University of Pennsylvania, Perelman Center for Advanced Medicine, Philadelphia (EL); and Department of Orthopaedics Alpert Medical School of Brown University, 593 Eddy Street, Providence, RI 02903 (KS).
authors.forename: Kunal
authors.initials: K
authors.lastname: Sindhu
authors.affiliation: From the Department of Orthopaedics, Alpert Medical School, Brown University, Providence, RI (SFD, JAG, SR); the Department of Urology, University of Pennsylvania, Perelman Center for Advanced Medicine, Philadelphia (EL); and Department of Orthopaedics Alpert Medical School of Brown University, 593 Eddy Street, Providence, RI 02903 (KS).
authors.forename: Scott
authors.initials: S
authors.lastname: Ritterman
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis / Q000379:methods*; D019643:Arthroplasty, Replacement / Q000009:adverse effects*; D016470:Bacteremia / Q000209:etiology / Q000517:prevention & control*; D006328:Cardiac Catheterization / Q000009:adverse effects; D003113:Colonoscopy / Q000009:adverse effects; D003558:Cystoscopy / Q000009:adverse effects; D003729:Dental Care / Q000009:adverse effects; D006801:Humans; D011300:Preoperative Care / Q000379:methods*; D016459:Prosthesis-Related Infections / Q000209:etiology / Q000517:prevention & control*
chemical_list: D000900:Anti-Bacterial Agents
keywords: Antibacterial Agents; Antibiotic Prophylaxis; Infectious Arthritis; Replacement Arthroplasty