title: [Not Available].
abstract: ANALGESIC ACTIVITY OF DIFFERENTS NONVOLATILS EXTRACTS OF NEPETA ATLANTICA BALL AND NEPETA TUBEROSA L. SSP. RETICULATA (DESF.) MAIRE: Different extracts of Nepeta atlantica Ball and Nepeta tuberosa L. ssp. reticulata (Desf.) Maire contain mainly a secondary metabolites with iridoïd lactonic and glucosidic type, also with triterpine lupan type. The aerial part of each species is crushed, then extracted in methanol by cold maceration, called global extracts. The global extracts will be extracted trough various solvents: initially by hexan then by the dichloromethan after that by the ethyl acetate and at the end by the buthanol. Each one of obtained extracts will be used for the following trials: i) Tail flick trial on the rat for the central morphine like analgesic activity; ii) Koster trial on the mouse for the peripheral analgesic activity. The evaluation of the central and peripheral analgesic activities for the pre cited extracts was realized after optimal doses determination of the global extracts activities for both species. The peripheral analgesic activity test on the mouse showed that, for 60 mg/kg intra peritoneum (IP), the hexanic, dichloromethanic, ethyl acetate and butanic extracts have a protection power against abdominal cramp respectively around 89.78%, 81.73%, 70.9% et 69.05% for Nepeta atlantica Ball, and arround 89.16%, 82.98%, 71.52% et 70.27% for Nepeta tuberosa L. ssp. reticulata. Central morphine like analgesic activity on the rat showed that, for both spices under 60 mg/kg IP, the central analgesic activity effect is significatly for two extracts only: dichloromethan and ethyl acetate.
authors.affiliation: Laboratoire de Chimie des Plantes et de Synthèse Organique et Bioorganique, Faculté des Sciences, Rabat, Maroc; Laboratoire de Pharmacologie et Toxicologie, Faculté de Médecine et de Pharmacie, Rabat, Maroc; Laboratoire National de Contrôle des Médicaments, Direction du Médicament et de la Pharmacie, Rabat, Maroc. Electronic address: bouididae@yahoo.fr.
authors.forename: El Houcine
authors.initials: el H
authors.lastname: Bouidida
authors.affiliation: Laboratoire de Pharmacologie et Toxicologie, Faculté de Médecine et de Pharmacie, Rabat, Maroc.
authors.forename: Katim
authors.initials: K
authors.lastname: Alaoui
authors.affiliation: Laboratoire de Pharmacologie et Toxicologie, Faculté de Médecine et de Pharmacie, Rabat, Maroc; Laboratoire National de Contrôle des Médicaments, Direction du Médicament et de la Pharmacie, Rabat, Maroc.
authors.forename: Yahia
authors.initials: Y
authors.lastname: Cherrah
authors.affiliation: Laboratoire de Chimie des Plantes et de Synthèse Organique et Bioorganique, Faculté des Sciences, Rabat, Maroc.
authors.forename: Malika
authors.initials: M
authors.lastname: Chammache
authors.affiliation: Laboratoire de Chimie des Plantes et de Synthèse Organique et Bioorganique, Faculté des Sciences, Rabat, Maroc.
authors.forename: Abdelkader
authors.initials: A
authors.lastname: Il Idrissi
keywords: L. ssp. reticulata; Nepeta atlantica; Nepeta tuberosa; action analgésique; analgesic activity; extraits non-volatil; nonvolatil extracts