title: Looking Beyond Structure: Membrane Phospholipids of Skeletal Muscle Mitochondria.
abstract: Skeletal muscle mitochondria are highly dynamic and are capable of tremendous expansion to meet cellular energetic demands. Such proliferation in mitochondrial mass requires a synchronized supply of enzymes and structural phospholipids. While transcriptional regulation of mitochondrial enzymes has been extensively studied, there is limited information on how mitochondrial membrane lipids are generated in skeletal muscle. Herein we describe how each class of phospholipids that constitute mitochondrial membranes are synthesized and/or imported, and summarize genetic evidence indicating that membrane phospholipid composition represents a significant modulator of skeletal muscle mitochondrial respiratory function. We also discuss how skeletal muscle mitochondrial phospholipids may mediate the effect of diet and exercise on oxidative metabolism.
authors.affiliation: East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC, USA; Department of Kinesiology, East Carolina University, Greenville, NC, USA.
authors.forename: Timothy D
authors.initials: TD
authors.lastname: Heden
authors.affiliation: East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC, USA; Department of Physiology, East Carolina University, Greenville, NC, USA.
authors.forename: P Darrell
authors.initials: PD
authors.lastname: Neufer
authors.affiliation: East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC, USA; Department of Kinesiology, East Carolina University, Greenville, NC, USA; Department of Physiology, East Carolina University, Greenville, NC, USA. Electronic address: funaik@ecu.edu.
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Funai
mesh_terms: D000818:Animals; D006801:Humans; D008563:Membrane Lipids / Q000378:metabolism; D008931:Mitochondria, Muscle / Q000378:metabolism*; D051336:Mitochondrial Membranes / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*
chemical_list: D008563:Membrane Lipids; D010743:Phospholipids
keywords: aerobic capacity.; membrane phospholipids; mitochondria; phospholipid biosynthesis; skeletal muscle