title: Frequencies of ALK rearrangements in lung adenocarcinoma subtypes: a study of 2299 Chinese cases.
abstract: OBJECTIVE
  This study aimed to determine the relationship between ALK status and lung adenocarcinoma subtypes, according to the IALSC/ATS/ERS classification in Chinese patients.
  
  
  METHODS
  A reclassification of 2299 surgically resected lung adenocarcinomas was performed, and ALK status was detected by immunohistochemistry (Ventana Medical Systems) in Shanghai Chest Hospital.
  
  
  RESULTS
  ALK rearrangements were identified in 93 of 2299 tumors (4.0 %). The ALK rearrangements frequencies were: 14.8 % (16/108), 10.3 % (20/195), 7.6 % (13/170), 2.8 % (29/1035), 2.5 % (3/119), 2.0 % (11/539), 0.9 % (1/114), and 0 % (0/19) for variants of invasive adenocarcinoma, solid predominant, micropapillary predominant, acinar predominant, minimally invasive adenocarcinoma, papillary predominant, lepidic predominant, and adenocarcinoma in situ, respectively.
  
  
  CONCLUSIONS
  We reported significant discrepancies of ALK status in lung adenocarcinoma subtypes in Chinese patients.
authors.affiliation: Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, 241 West Huaihai Road, Xuhui District, Shanghai, 200030 China.
authors.forename: Yongfeng
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, 241 West Huaihai Road, Xuhui District, Shanghai, 200030 China.
authors.forename: Zhengping
authors.initials: Z
authors.lastname: Ding
authors.affiliation: Department of Pathology, Shanghai Chest Hospital, Shanghai Jiao Tong University, 241 West Huaihai Road, Xuhui District, Shanghai, 200030 China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Department of Pathology, Shanghai Chest Hospital, Shanghai Jiao Tong University, 241 West Huaihai Road, Xuhui District, Shanghai, 200030 China.
authors.forename: Haohua
authors.initials: H
authors.lastname: Teng
authors.affiliation: Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, 241 West Huaihai Road, Xuhui District, Shanghai, 200030 China.
authors.forename: Shun
authors.initials: S
authors.lastname: Lu
keywords: ALK status; Histologic classification; Lung adenocarcinoma