title: Prognostic factors for 1-week survival in dogs diagnosed with meningoencephalitis of unknown aetiology.
abstract: Although long-term outcomes of meningoencephalitis of unknown aetiology (MUA) in dogs have been evaluated, little is known about short-term survival and initial response to therapy. The aim of this study was to evaluate possible prognostic factors for 7-day survival after diagnosis of MUA in dogs. Medical records were reviewed for dogs diagnosed with MUA between 2006 and 2015. Previously described inclusion criteria were used, as well as 7-day survival data for all dogs. A poor outcome was defined as death within 1 week. Of 116 dogs that met inclusion criteria, 30 (26%) died within 7 days of diagnosis. Assessed variables included age, sex, bodyweight, duration of clinical signs and treatment prior to diagnosis, venous blood glucose and lactate levels, white blood cell count on complete blood count, total nucleated cell count/total protein concentration/white blood cell differentiation on cerebrospinal fluid (CSF) analysis, presence of seizures and cluster seizures, mentation at presentation, neuroanatomical localisation, imaging findings and treatment after diagnosis. Multivariate analysis identified three variables significantly associated with poor outcome; decreased mentation at presentation, presence of seizures, and increased percentage of neutrophils on CSF analysis. Despite initiation of appropriate treatment, more than a quarter of dogs died within 1 week of diagnosis of MUA, emphasising the need for evaluation of short-term prognostic factors. Information from this study could aid clinical staff to provide owners of affected dogs with prognostic information.
authors.affiliation: Clinical Science and Services, The Royal Veterinary College, University of London, Hatfield, UK; Department of Medicine and Clinical Biology of Small Animal, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium. Electronic address: ine.cornelis@ugent.be.
authors.forename: I
authors.initials: I
authors.lastname: Cornelis
authors.affiliation: Clinical Science and Services, The Royal Veterinary College, University of London, Hatfield, UK.
authors.forename: H A
authors.initials: HA
authors.lastname: Volk
authors.affiliation: Department of Medicine and Clinical Biology of Small Animal, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium.
authors.forename: L
authors.initials: L
authors.lastname: Van Ham
authors.affiliation: Clinical Science and Services, The Royal Veterinary College, University of London, Hatfield, UK.
authors.forename: S
authors.initials: S
authors.lastname: De Decker
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D004285:Dogs; D005260:Female; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008131:London; D008136:Longevity; D008297:Male; D008590:Meningoencephalitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000662:veterinary*; D015999:Multivariate Analysis; D011379:Prognosis; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D007166:Immunosuppressive Agents
keywords: GME; Inflammatory CNS disease; MRI; MUO; Necrotising encephalitis