title: Current concepts in chronic inflammatory diseases: Interactions between microbes, cellular metabolism, and inflammation.
abstract: Recent research indicates that chronic inflammatory diseases, including allergies and autoimmune and neuropsychiatric diseases, share common pathways of cellular and molecular dysregulation. It was the aim of the International von-Behring-Röntgen Symposium (October 16-18, 2014, in Marburg, Germany) to discuss recent developments in this field. These include a concept of biodiversity; the contribution of urbanization, lifestyle factors, and nutrition (eg, vitamin D); and new mechanisms of metabolic and immune dysregulation, such as extracellular and intracellular RNAs and cellular and mitochondrial stress. Epigenetic mechanisms contribute further to altered gene expression and therefore to the development of chronic inflammation. These novel findings provide the foundation for further development of preventive and therapeutic strategies.
authors.affiliation: Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, University of Marburg, Marburg, Germany.
authors.forename: Holger
authors.initials: H
authors.lastname: Garn
authors.affiliation: Centre for Neuropsychiatric Research, Cambridge University, Cambridge, United Kingdom.
authors.forename: Sabine
authors.initials: S
authors.lastname: Bahn
authors.affiliation: Discipline of Psychiatry, University of Adelaide, Adelaide, Australia.
authors.forename: Bernhard T
authors.initials: BT
authors.lastname: Baune
authors.affiliation: Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.
authors.forename: Elisabeth B
authors.initials: EB
authors.lastname: Binder
authors.affiliation: Faculty of Health Sciences, COPSAC, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Hans
authors.initials: H
authors.lastname: Bisgaard
authors.affiliation: Boston Children's Hospital, Harvard University, Boston, Mass.
authors.forename: Talal A
authors.initials: TA
authors.lastname: Chatila
authors.affiliation: Clinical Pathobiochemistry, Technical University Dresden, Dresden, Germany.
authors.forename: Triantafyllos
authors.initials: T
authors.lastname: Chavakis
authors.affiliation: Institute for Pharmacology and Clinical Pharmacy, University of Marburg, Marburg, Germany.
authors.forename: Carsten
authors.initials: C
authors.lastname: Culmsee
authors.affiliation: Department of Psychiatry, University of Munster, Munster, Germany; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
authors.forename: Udo
authors.initials: U
authors.lastname: Dannlowski
authors.affiliation: Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Steffen
authors.initials: S
authors.lastname: Gay
authors.affiliation: Division Allergy and Immunology, Clinical Science Center, Madison, Wis.
authors.forename: James
authors.initials: J
authors.lastname: Gern
authors.affiliation: Skin and Allergy Hospital, University Hospital Helsinki, Helsinki, Finland.
authors.forename: Tari
authors.initials: T
authors.lastname: Haahtela
authors.affiliation: Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
authors.forename: Tilo
authors.initials: T
authors.lastname: Kircher
authors.affiliation: Clinic of Rheumatology and Clinical Immunology, University of Giessen, Giessen, Germany.
authors.forename: Ulf
authors.initials: U
authors.lastname: Müller-Ladner
authors.affiliation: Medical Clinic of Gastroenterology, Pneumonology, Endocrinology, University of Erlangen, Erlangen, Germany.
authors.forename: Markus F
authors.initials: MF
authors.lastname: Neurath
authors.affiliation: Department of Biochemistry, Medical Faculty, University of Giessen, Giessen, Germany.
authors.forename: Klaus T
authors.initials: KT
authors.lastname: Preissner
authors.affiliation: Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Mainz, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Reinhardt
authors.affiliation: Centre for Clinical Microbiology, University College London, London, United Kingdom.
authors.forename: Graham
authors.initials: G
authors.lastname: Rook
authors.affiliation: Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Shannon
authors.initials: S
authors.lastname: Russell
authors.affiliation: Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Member of the German Center for Lung Research (DZL), Philipps-University Marburg, and the Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Marburg, Germany.
authors.forename: Bernd
authors.initials: B
authors.lastname: Schmeck
authors.affiliation: Department of Pathology and Immunology, Washington University, St Louis, Mo.
authors.forename: Thaddeus
authors.initials: T
authors.lastname: Stappenbeck
authors.affiliation: Institute of Medical Microbiology, University of Marburg, Marburg, Germany.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Steinhoff
authors.affiliation: Department of Psychiatry and Psychology, Maastricht University, Maastricht, The Netherlands.
authors.forename: Jim
authors.initials: J
authors.lastname: van Os
authors.affiliation: Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.
authors.forename: Scott
authors.initials: S
authors.lastname: Weiss
authors.affiliation: Children's Hospital, University of Marburg, Marburg, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Zemlin
authors.affiliation: Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, University of Marburg, Marburg, Germany. Electronic address: harald.renz@uk-gm.de.
authors.forename: Harald
authors.initials: H
authors.lastname: Renz
mesh_terms: D000818:Animals; D002908:Chronic Disease; D004734:Energy Metabolism; D004777:Environment; D020022:Genetic Predisposition to Disease; D054884:Host-Pathogen Interactions / Q000235:genetics / Q000276:immunology; D006801:Humans; D007109:Immunity; D007249:Inflammation / Q000209:etiology* / Q000378:metabolism*; D064307:Microbiota / Q000276:immunology
keywords: Chronic inflammation; biodiversity; environment; epigenetics; immune dysregulation; metabolism; stress