title: A Carbonylation Approach Toward Activation of Csp2-H and Csp3-H Bonds: Cu-Catalyzed Regioselective Cross Coupling of Imidazo[1,2-a]pyridines with Methyl Hetarenes.
abstract: An efficient copper-catalyzed selective cross coupling of imidazo[1,2-a]pyridines with methyl hetarenes has been reported. This transformation opened a new route to synthesize the C-3 carbonyl imidazo[1,2-a]pyridine derivative, which is a common structural motif in natural products and pharmaceuticals. (18)O-labeling experiments indicated that the oxygen source of products originated from O2.
authors.affiliation: School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University , Zhongshan 528458, China.
authors.forename: Sai
authors.initials: S
authors.lastname: Lei
authors.affiliation: School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University , Zhongshan 528458, China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Mai
authors.affiliation: School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University , Zhongshan 528458, China.
authors.forename: Caijuan
authors.initials: C
authors.lastname: Yan
authors.affiliation: Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances and School of Basic Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China.
authors.forename: Jianwen
authors.initials: J
authors.lastname: Mao
authors.affiliation: School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University , Zhongshan 528458, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Cao