title: Altered resting-state functional organization within the central executive network in obsessive-compulsive disorder.
abstract: OBJECTIVE
  Obsessive-compulsive disorder (OCD) is associated with deficits in response inhibition and planning, which are governed by the central executive network. The objective of this study was to investigate both intra- and inter-regional resting-state connectivity within the central executive network in OCD.
  
  
  METHODS
  Thirty OCD patients and 30 matched healthy controls were scanned using resting-state functional magnetic resonance imaging. The independent component analysis was used on a separate sample of healthy controls to generate the central executive network mask for the subsequent OCD analyses. Regional homogeneity (ReHo) and seed-based functional connectivity analyses were used to explore the differences between intra- and inter-regional synchronized activity within the central executive network in OCD patients at rest.
  
  
  RESULTS
  Increased ReHo and functional connectivity in the key regions of the central executive network, such as the orbitofrontal cortex, dorsolateral prefrontal cortex, and the angular gyrus, were found in OCD patients. Furthermore, changes in both the ReHo within the orbitofrontal cortex and the functional connectivity between the orbitofrontal cortex and angular gyrus were negatively correlated with OCD duration.
  
  
  CONCLUSIONS
  The increased resting-state functional organization within the central executive network may be related to OCD patients' deficits in cognitive control and symptom progression.
authors.affiliation: Department of Psychiatry, Qiqihar Medical University, Qiqihar, China.
authors.forename: Yunhui
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Radiology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Meng
authors.affiliation: Department of Clinical Psychology, Qiqihar Mental Health Center, Qiqihar, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Hu
authors.affiliation: Department of Radiology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, China.
authors.forename: Hongsheng
authors.initials: H
authors.lastname: Cui
authors.affiliation: Department of Psychiatry, Qiqihar Medical University, Qiqihar, China.
authors.forename: Yongzhuo
authors.initials: Y
authors.lastname: Ding
authors.affiliation: Department of Psychiatry, Qiqihar Medical University, Qiqihar, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Kang
authors.affiliation: Department of Psychiatry, University of Alberta, Edmonton, Canada.
authors.forename: Michal
authors.initials: M
authors.lastname: Juhás
authors.affiliation: Department of Psychiatry, University of Alberta, Edmonton, Canada.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Greenshaw
authors.affiliation: Department of Psychiatry, Qiqihar Medical University, Qiqihar, China.
authors.forename: Ameng
authors.initials: A
authors.lastname: Zhao
authors.affiliation: Department of Psychiatry, Qiqihar Medical University, Qiqihar, China.
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Psychiatry, Qiqihar Medical University, Qiqihar, China.
authors.forename: Guangcheng
authors.initials: G
authors.lastname: Cui
authors.affiliation: Department of Psychiatry, Qiqihar Medical University, Qiqihar, China. lipingchxyy@163.com.
authors.forename: Ping
authors.initials: P
authors.lastname: Li
mesh_terms: D000328:Adult; D001931:Brain Mapping / Q000379:methods*; D056344:Executive Function / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009415:Nerve Net / Q000503:physiopathology*; D009771:Obsessive-Compulsive Disorder / Q000503:physiopathology*; D017397:Prefrontal Cortex / Q000503:physiopathology*; D055815:Young Adult
keywords: central executive network; functional connectivity; independent component analysis; obsessive-compulsive disorder; regional homogeneity