title: Obesity and facial dysmorphism in an adolescent patient with a 16p11.2 microdeletion.
abstract: A 17-year-old mixed race male has been followed in our adolescent clinic for severe obesity, dysmorphic features, and behavioral issues. Among other interventions, he has received symptomatic treatment for hypertension, insulin resistance, and attention deficit hyperactivity disorder. Genetic investigation identified a 16p11.2 microdeletion, commonly associated with severe obesity and developmental delay. We present the clinical history, treatment, and implications for this patient.
authors.affiliation: University of Missouri School of Medicine, MA215 Medical Sciences Building, Columbia, Missouri 65212, MO,USA.
authors.forename: Aaron M
authors.initials: AM
authors.lastname: Schuh
authors.affiliation: University of Missouri School of Medicine, Columbia, MO, USA.
authors.forename: Jacob D
authors.initials: JD
authors.lastname: Taylor
authors.affiliation: University of Missouri School of Medicine, Department of Child Health: Genetics Division, Columbia, MO, USA.
authors.forename: Esperanza E
authors.initials: EE
authors.lastname: Font-Montgomery
authors.affiliation: University of Missouri School of Medicine, Department of Child Health: Adolescent Division, 1 Hospital Dr., Columbia, MO, USA.
authors.forename: Aneesh K
authors.initials: AK
authors.lastname: Tosh
keywords: 16p11.2; adolescent; dysmorphism; microdeletion; obesity