title: Multiple Cutaneous Metastasis of a Malignant Leydig Cell Tumour in a Dog.
abstract: A testicular Leydig cell tumour associated with metastatic disease is reported in a dog. An enlarged testis and three cutaneous nodules resected from an 11-year-old golden retriever were submitted for histopathological examination. Both testicular and cutaneous lesions showed identical morphological and cytological changes. Immunohistochemical labelling for expression of inhibin-α and calretinin confirmed the Leydig origin of the cutaneous neoplastic population. Based on the morphological and immunohistochemical findings, a final diagnosis of multiple cutaneous metastasis of a malignant testicular Leydig cell tumour was made.
authors.affiliation: Pathology and Immunology Department, Institute of Biomedical Sciences Abel Salazar, ICBAS-UP, University of Porto, Portugal.
authors.forename: A
authors.initials: A
authors.lastname: Canadas
authors.affiliation: Romão Veterinários, Small Animal Clinic, Vila Nova de Famalicão, Portugal.
authors.forename: P
authors.initials: P
authors.lastname: Romão
authors.affiliation: Pathology and Immunology Department, Institute of Biomedical Sciences Abel Salazar, ICBAS-UP, University of Porto, Portugal; Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal; Instituto de Investigação e Inovação em Saúde da Universidade do Porto (i3S), Porto, Portugal. Electronic address: fgartner@ipatimup.pt.
authors.forename: F
authors.initials: F
authors.lastname: Gärtner
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D007150:Immunohistochemistry; D007984:Leydig Cell Tumor / Q000662:veterinary*; D008297:Male; D012878:Skin Neoplasms / Q000662:veterinary; D013736:Testicular Neoplasms / Q000662:veterinary*
chemical_list: D014408:Biomarkers, Tumor
keywords: Leydig cell tumour; dog; immunohistochemistry; metastasis