title: [Not Available].
abstract: OBJECTIVE
  We carried out this study in order to evaluate the effectiveness and the safety of the two H1N1 vaccines available in Tunisia: Focetria® and Panenza®.
  
  
  METHODS
  It's a prospective epidemiological study including 601 vaccinated subjects. The vaccine effectiveness was based on the occurrence of flu clinical symptoms after vaccination. The safety was based on the occurrence of unexpected events after vaccines administration. The vaccines imputability was established according to Begaud et al.
  
  
  RESULTS
  The number of subjects vaccinated by Focetria® is more important than Panenza®. The efficiency of vaccines would be 93.6%. Neither the medical statue nor the type of the vaccine used influence the occurrence of a flu episode after vaccination. We recorded 406 adverse effects (32.4%) with a high score of imputability (I3). Focetria® adverse effects were more frequent than Panenza® ones (p=0.009). Almost all adverse events disappeared within few days.
  
  
  CONCLUSIONS
  The two vaccines used in Tunisia remain enough efficient to face the influenza (H1N1) pandemia and are well tolerated independently of the demographic and pathological statue of the vaccinated person as well as nature of the vaccine used.
authors.affiliation: Laboratoire de Pharmacologie, Faculté de Médecine, Monastir, Tunisie. Electronic address: chaabane_amel@yahoo.fr.
authors.forename: Amel
authors.initials: A
authors.lastname: Chaabane
authors.affiliation: Laboratoire de Pharmacologie, Faculté de Médecine, Monastir, Tunisie.
authors.forename: Karim
authors.initials: K
authors.lastname: Aouam
authors.affiliation: Laboratoire de Pharmacologie, Faculté de Médecine, Monastir, Tunisie.
authors.forename: Nadia Ben
authors.initials: NB
authors.lastname: Fredj
authors.affiliation: Service de Maladies Infectieuses, CHU Fattouma Bourguiba, Monastir, Tunisie.
authors.forename: Adnen
authors.initials: A
authors.lastname: Toumi
authors.affiliation: Laboratoire de Pharmacologie, Faculté de Médecine, Monastir, Tunisie.
authors.forename: Dorra
authors.initials: D
authors.lastname: Braham
authors.affiliation: Laboratoire de Pharmacologie, Faculté de Médecine, Monastir, Tunisie.
authors.forename: Naceur A
authors.initials: NA
authors.lastname: Boughattas
authors.affiliation: Service de Maladies Infectieuses, CHU Fattouma Bourguiba, Monastir, Tunisie.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Chakroun
keywords: H1N1; adverse effect; effet indésirable; efficacité; efficiency; grippe; influenza; vaccin; vaccine