title: Understanding perspectives of signalling mechanisms regulating PEBP1 function.
abstract: Phosphatidylethanolamine-binding protein 1 (PEBP1), also known as Raf kinase inhibitor protein, belongs to PEBP family of proteins. It is known to interact with many proteins that are mainly involved in pathways that monitor cell proliferation and differentiation. PEBP1 in many cells interacts with several pathways, namely MAPK, GRK2, NF-кB, etc. that keeps the cell proliferation and differentiation in check. This protein is expressed by many cells in humans, including neurons where it is predominantly involved in production of choline acetyltransferase. Deregulated PEBP1 is known to cause cancer, diabetic nephropathy and neurodegenerative diseases like Alzheimer's and dementia. Recent research led to the discovery of many drugs that mainly target the interaction of PEBP1 with its partners. These compounds are known to bind PEBP1 in its conserved domain which abrogate its association with interacting partners in several different pathways. We outline here the latest developments in understanding of PEBP1 function in maintaining cell integrity. Copyright © 2016 John Wiley & Sons, Ltd.
  
  
  CONCLUSIONS
  Phosphatidylethanolamine-binding protein is crucial in regulation of MAPK and PKC pathways. Its diverse roles, including regulating these pathways keep cell differentiation and proliferation in check. This review outlines some latest findings which greatly add to our current knowledge of phosphatidylethanolamine-binding protein.
authors.affiliation: Department of Microbiology, Osmania University, Hyderabad, India.
authors.forename: Karthik
authors.initials: K
authors.lastname: Rajkumar
authors.affiliation: Department of Microbiology, Osmania University, Hyderabad, India.
authors.forename: Aare
authors.initials: A
authors.lastname: Nichita
authors.affiliation: Department of Microbiology, Osmania University, Hyderabad, India.
authors.forename: Pawan Kumar
authors.initials: PK
authors.lastname: Anoor
authors.affiliation: Department of Microbiology, Osmania University, Hyderabad, India.
authors.forename: Swathi
authors.initials: S
authors.lastname: Raju
authors.affiliation: Department of Biochemistry, Osmania University, Hyderabad, India.
authors.forename: Surya Satyanarayana
authors.initials: SS
authors.lastname: Singh
authors.affiliation: Department of Microbiology, Osmania University, Hyderabad, India.
authors.forename: Sandeepta
authors.initials: S
authors.lastname: Burgula
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008954:Models, Biological; D058990:Molecular Targeted Therapy; D049488:Phosphatidylethanolamine Binding Protein / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D049488:Phosphatidylethanolamine Binding Protein
keywords: MAPK; PEBP1; RKIP; cancer; neurodegeneration