title: Nephronectin Expression Is Up-Regulated by BMP-2.
abstract: Nephronectin (Npnt), known to be a ligand of integrin α8β1, plays important roles in the development and function of various tissues, including those of the kidneys, liver, bones, and muscles. In previous studies, we showed that the expression of Npnt mRNA was regulated by various cytokines, including transforming growth factor-β (TGF-β), tumor necrosis factor-α (TNF-α), and oncostatin M (OSM), and that over-expression of Npnt enhanced osteoblast differentiation. In this study, we found that bone morphogenic protein-2 (BMP-2), known as an osteogenesis inducing cytokine, strongly up-regulated the expression of Npnt mRNA in a murine skeletal muscle cell line (C2C12) via the BMP-SMAD signaling pathway.
authors.affiliation: Department of Biochemistry, School of Dentistry, Showa University.
authors.forename: Tamaki
authors.initials: T
authors.lastname: Kurosawa
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yamada
authors.forename: Dai
authors.initials: D
authors.lastname: Suzuki
authors.forename: Naoko
authors.initials: N
authors.lastname: Morimura
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Sasagane
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Itabe
authors.forename: Ryutaro
authors.initials: R
authors.lastname: Kamijo
mesh_terms: D000818:Animals; D055396:Bone Morphogenetic Protein 2 / Q000235:genetics / Q000494:pharmacology*; D002460:Cell Line; D016326:Extracellular Matrix Proteins / Q000096:biosynthesis / Q000235:genetics*; D051379:Mice; D012333:RNA, Messenger / Q000096:biosynthesis; D011994:Recombinant Proteins / Q000494:pharmacology; D051785:Smad Proteins / Q000378:metabolism; D015854:Up-Regulation
chemical_list: C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2; D016326:Extracellular Matrix Proteins; D012333:RNA, Messenger; D011994:Recombinant Proteins; D051785:Smad Proteins; C432915:nephronectin