title: Evaluation of Anti-Inflammatory Potential of the New Ganghwaljetongyeum on Adjuvant-Induced Inflammatory Arthritis in Rats.
abstract: Ganghwaljetongyeum (GHJTY) has been used as a standard treatment for arthritis for approximately 15 years at the Korean Medicine Hospital of Dongshin University. GHJTY is composed of 18 medicinal herbs, of which five primary herbs were selected and named new Ganghwaljetongyeum (N-GHJTY). The purpose of the present study was to observe the effect of N-GHJTY on arthritis and to determine its mechanism of action. After confirming arthritis induction using complete Freund's adjuvant (CFA) in rats, N-GHJTY (62.5, 125, and 250 mg/kg/day) was administered once a day for 10 days. In order to determine pathological changes, edema of the paws and weight were measured before and for 10 days after N-GHJTY administration. Cytokine (TNF-α, IL-1β, and IL-6) levels and histopathological lesions in the knee joint were also examined. Edema in the paw and knee joint of N-GHJTY-treated rats was significantly decreased at 6, 8, and 10 days after administration, compared to that in the CFA-control group, while weight consistently increased. Rats in N-GHJTY-treated groups also recovered from the CFA-induced pathological changes and showed a significant decline in cytokine levels. Taken together, our results showed that N-GHJTY administration was effective in inhibiting CFA-induced arthritis via anti-inflammatory effects while promoting cartilage recovery by controlling cytokine levels.
authors.affiliation: College of Korean Medicine, Dongshin University, 185 Geonjae-ro, Naju-si, Jeollanam-do 58245, Republic of Korea.
authors.forename: Wangin
authors.initials: W
authors.lastname: Kim
authors.affiliation: College of Korean Medicine, Dongshin University, 185 Geonjae-ro, Naju-si, Jeollanam-do 58245, Republic of Korea.
authors.forename: Sangbin
authors.initials: S
authors.lastname: Park
authors.affiliation: College of Korean Medicine, Dongshin University, 185 Geonjae-ro, Naju-si, Jeollanam-do 58245, Republic of Korea.
authors.forename: Chanhun
authors.identifier: 0000-0002-0239-9663
authors.initials: C
authors.lastname: Choi
authors.affiliation: College of Pharmacy, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Republic of Korea.
authors.forename: Youg Ran
authors.initials: YR
authors.lastname: Kim
authors.affiliation: College of Medicine, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Republic of Korea.
authors.forename: Inkyu
authors.identifier: 0000-0002-8522-8236
authors.initials: I
authors.lastname: Park
authors.affiliation: Mibyeong Research Center, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, Republic of Korea.
authors.forename: Changseob
authors.identifier: 0000-0002-8156-446X
authors.initials: C
authors.lastname: Seo
authors.affiliation: College of Korean Medicine, Dongshin University, 185 Geonjae-ro, Naju-si, Jeollanam-do 58245, Republic of Korea.
authors.forename: Daehwan
authors.identifier: 0000-0003-1615-9887
authors.initials: D
authors.lastname: Youn
authors.affiliation: College of Korean Medicine, Dongshin University, 185 Geonjae-ro, Naju-si, Jeollanam-do 58245, Republic of Korea.
authors.forename: Wook
authors.initials: W
authors.lastname: Shin
authors.affiliation: College of Korean Medicine, Dongshin University, 185 Geonjae-ro, Naju-si, Jeollanam-do 58245, Republic of Korea.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Lee
authors.affiliation: College of Korean Medicine, Dongshin University, 185 Geonjae-ro, Naju-si, Jeollanam-do 58245, Republic of Korea.
authors.forename: Donghee
authors.initials: D
authors.lastname: Choi
authors.affiliation: College of Korean Medicine, Dongshin University, 185 Geonjae-ro, Naju-si, Jeollanam-do 58245, Republic of Korea.
authors.forename: Mirae
authors.initials: M
authors.lastname: Kim
authors.affiliation: School of Information and Communications, Gwangju Institute of Science and Technology, 123 Cheomdangwagi-ro, Buk-gu, Gwangju 61005, Republic of Korea.
authors.forename: Hyunju
authors.initials: H
authors.lastname: Lee
authors.affiliation: College of Korean Medicine, Dongshin University, 185 Geonjae-ro, Naju-si, Jeollanam-do 58245, Republic of Korea.
authors.forename: Seonjong
authors.initials: S
authors.lastname: Kim
authors.affiliation: College of Korean Medicine, Dongshin University, 185 Geonjae-ro, Naju-si, Jeollanam-do 58245, Republic of Korea.
authors.forename: Changsu
authors.initials: C
authors.lastname: Na