title: Mesenchymal stromal cell therapy in ischemic heart disease.
abstract: Although, treatment of ischemic heart disease (IHD) has improved considerably within the last decades, it is still the main cause of death worldwide. Despite maximum treatment, many IHD patients suffer from refractory angina and heart failure, which severely limits their daily lives. Moreover, IHD is very costly for the health care system. Therefore, new treatment options and strategies are being researched intensely. Stem cell therapy to improve myocardial perfusion and stimulate growth of new cardiomyocytes could be a new way to go. Nevertheless, the results from clinical studies have varied considerably, probably due to the use of many different cell lines obtained from different tissues and the different patient populations. The present review will focus on treatment with the mesenchymal stromal cell from bone marrow and adipose tissue in animal and patients with acute and chronic IHD (CIHD).
authors.affiliation: a Department of Cardiology , The Heart Centre, Rigshospitalet, University Hospital of Copenhagen , Copenhagen , Denmark.|b Cardiology Stem Cell Centre, The Heart Centre, Rigshospitalet, University Hospital of Copenhagen , Copenhagen , Denmark.
authors.forename: Jens
authors.initials: J
authors.lastname: Kastrup
authors.affiliation: a Department of Cardiology , The Heart Centre, Rigshospitalet, University Hospital of Copenhagen , Copenhagen , Denmark.
authors.forename: Naja Dam
authors.initials: ND
authors.lastname: Mygind
authors.affiliation: a Department of Cardiology , The Heart Centre, Rigshospitalet, University Hospital of Copenhagen , Copenhagen , Denmark.
authors.forename: Abbas Ali
authors.initials: AA
authors.lastname: Qayyum
authors.affiliation: a Department of Cardiology , The Heart Centre, Rigshospitalet, University Hospital of Copenhagen , Copenhagen , Denmark.
authors.forename: Anders Bruun
authors.initials: AB
authors.lastname: Mathiasen
authors.affiliation: b Cardiology Stem Cell Centre, The Heart Centre, Rigshospitalet, University Hospital of Copenhagen , Copenhagen , Denmark.
authors.forename: Mandana
authors.initials: M
authors.lastname: Haack-Sørensen
authors.affiliation: b Cardiology Stem Cell Centre, The Heart Centre, Rigshospitalet, University Hospital of Copenhagen , Copenhagen , Denmark.
authors.forename: Annette
authors.initials: A
authors.lastname: Ekblond
mesh_terms: D000273:Adipose Tissue / Q000166:cytology*; D000818:Animals; D001854:Bone Marrow Cells / Q000502:physiology*; D016026:Bone Marrow Transplantation; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000502:physiology*; D017202:Myocardial Ischemia / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D009206:Myocardium / Q000473:pathology*; D010641:Phenotype; D012038:Regeneration; D016896:Treatment Outcome
keywords: Adipose-derived stromal cell; heart failure; ischemic heart disease; mesenchymal stromal cell; refractory angina; review; stem cell; therapy