title: Arrested development: coordinating regeneration with development and growth in Drosophila melanogaster.
abstract: The capacity for tissues to regenerate often varies during development. A better understanding how developmental context regulates regenerative capacity will be an important step towards enhancing the regenerative capacity of tissues to repair disease or damage. Recent work examining the regeneration of imaginal discs in the fruit fly, Drosophila melanogaster, has begun to identify mechanisms by which developmental progress restricts regeneration, and elucidate how Drosophila coordinates regenerative repair with the growth and development of the entire organism. Here we review recent advances in describing the interplay between development and tissue regeneration in Drosophila and identify questions that arise from these findings.
authors.affiliation: Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, United States.
authors.forename: Jacob S
authors.initials: JS
authors.lastname: Jaszczak
authors.affiliation: Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, United States. Electronic address: ajh6a@virginia.edu.
authors.forename: Adrian
authors.initials: A
authors.lastname: Halme
mesh_terms: D000818:Animals; D019521:Body Patterning / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics*; D004331:Drosophila melanogaster / Q000235:genetics* / Q000254:growth & development; D047108:Embryonic Development / Q000235:genetics*; D060227:Imaginal Discs / Q000254:growth & development; D012038:Regeneration / Q000235:genetics*; D014945:Wound Healing / Q000235:genetics