title: Effect of Transcatheter Mitral Annuloplasty With the Cardioband Device on 3-Dimensional Geometry of the Mitral Annulus.
abstract: This study was performed to assess the acute intraprocedural effects of transcatheter direct mitral annuloplasty using the Cardioband device on 3-dimensional (3D) anatomy of the mitral annulus. Of 45 patients with functional mitral regurgitation (MR) enrolled in a single arm, multicenter, prospective trial, 22 had complete pre- and post-implant 3D transesophageal echocardiography (TEE) images stored in native data format that allowed off-line 3D reconstruction. Images with the highest volume rate and best image quality were selected for analysis. Multiple measurements of annular geometry were compared from baseline to post-implant using paired t tests with Bonferroni correction to account for multiple comparisons. The device was successfully implanted in all patients, and MR was reduced to moderate in 2 patients, mild in 17 patients, and trace in 3 patients after final device cinching. Compared with preprocedural TEE, postprocedural TEE showed statistically significantly reductions in annular circumference (137 ± 15 vs 128 ± 17 mm; p = 0.042), intercommissural distance (42.4 ± 4.3 vs 38.6 ± 4.4 mm; p = 0.029), anteroposterior distance (40.0 ± 5.4 vs 37.0 ± 5.7 mm; p = 0.025), and aortic-mitral angle (117 ± 8° vs 112 ± 8°; p = 0.032). This study demonstrates that transcatheter direct mitral annuloplasty with the Cardioband device results in acute remodeling of the mitral annulus with successful reduction of functional MR.
authors.affiliation: Baylor University Medical Center, Dallas, Texas.
authors.forename: Mani
authors.initials: M
authors.lastname: Arsalan
authors.affiliation: San Raffaele University Hospital, Milan, Italy.
authors.forename: Eustachio
authors.initials: E
authors.lastname: Agricola
authors.affiliation: San Raffaele University Hospital, Milan, Italy.
authors.forename: Ottavio
authors.initials: O
authors.lastname: Alfieri
authors.affiliation: Hart Center, University of Cologne, Cologne, Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Baldus
authors.affiliation: Interventional Cardiology Unit, San Raffaele Scientific Institute, Milan, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Colombo
authors.affiliation: Baylor University Medical Center, Dallas, Texas.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Filardo
authors.affiliation: Department of Cardiology, Heart Center Bonn, University Hospital Bonn, Germany.
authors.forename: Christophe
authors.initials: C
authors.lastname: Hammerstingl
authors.affiliation: Hart Center, University of Cologne, Cologne, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Huntgeburth
authors.affiliation: Department of Cardiology, Asklepios Klinik St. Georg Hospital, Hamburg, Germany.
authors.forename: Felix
authors.initials: F
authors.lastname: Kreidel
authors.affiliation: Department of Cardiology, Asklepios Klinik St. Georg Hospital, Hamburg, Germany.
authors.forename: Karl-Heinz
authors.initials: KH
authors.lastname: Kuck
authors.affiliation: San Raffaele University Hospital, Milan, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: LaCanna
authors.affiliation: Bichat Claude Bernard Hospital-Paris VII University, Paris, France.
authors.forename: David
authors.initials: D
authors.lastname: Messika-Zeitoun
authors.affiliation: Valve Clinic, University Heart Center, University Hospital Zürich, Zürich, Switzerland.
authors.forename: Francesco
authors.initials: F
authors.lastname: Maisano
authors.affiliation: Department of Cardiology, Heart Center Bonn, University Hospital Bonn, Germany.
authors.forename: Georg
authors.initials: G
authors.lastname: Nickenig
authors.affiliation: Baylor University Medical Center, Dallas, Texas.
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Pollock
authors.affiliation: Baylor University Medical Center, Dallas, Texas.
authors.forename: Bradley J
authors.initials: BJ
authors.lastname: Roberts
authors.affiliation: Bichat Claude Bernard Hospital-Paris VII University, Paris, France.
authors.forename: Alec
authors.initials: A
authors.lastname: Vahanian
authors.affiliation: Baylor University Medical Center, Dallas, Texas. Electronic address: paulgr@baylorhealth.edu.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Grayburn
mesh_terms: D000368:Aged; D006328:Cardiac Catheterization / Q000379:methods; D017548:Echocardiography, Transesophageal; D005260:Female; D005858:Germany; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000379:methods; D006801:Humans; D007558:Italy; D008297:Male; D058386:Mitral Valve Annuloplasty / Q000379:methods; D008944:Mitral Valve Insufficiency / Q000000981:diagnostic imaging / Q000601:surgery*; D011446:Prospective Studies; D011474:Prosthesis Design; D016037:Single-Blind Method; D016896:Treatment Outcome; D014481:United States