title: Mitochondrial function is altered in horse atypical myopathy.
abstract: Equine atypical myopathy in Europe is a fatal rhabdomyolysis syndrome that results from the ingestion of hypoglycin A contained in seeds and seedlings of Acer pseudoplatanus (sycamore maple). Acylcarnitine concentrations in serum and muscle OXPHOS capacity were determined in 15 atypical myopathy cases. All but one acylcarnitine were out of reference range and mitochondrial respiratory capacity was severely decreased up to 49% as compared to 10 healthy controls. The hallmark of atypical myopathy thus consists of a severe alteration in the energy metabolism including a severe impairment in muscle mitochondrial respiration that could contribute to its high death rate.
authors.affiliation: Faculty Saint-Jean, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Hélène
authors.initials: H
authors.lastname: Lemieux
authors.affiliation: Biochemical Genetics Laboratory, Human Genetics, CHU Liege, University of Liege, Belgium.
authors.forename: François
authors.initials: F
authors.lastname: Boemer
authors.affiliation: (c)Equine Clinic, Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, University of Liege, Belgium.
authors.forename: Gaby
authors.initials: G
authors.lastname: van Galen
authors.affiliation: (c)Equine Clinic, Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, University of Liege, Belgium; Centre of Oxygen, Research and Development, University of Liege, Liege, Belgium.
authors.forename: Didier
authors.initials: D
authors.lastname: Serteyn
authors.affiliation: (c)Equine Clinic, Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, University of Liege, Belgium.
authors.forename: Hélène
authors.initials: H
authors.lastname: Amory
authors.affiliation: (e)Department of Animal Productions: Biostatistics, Economy and Animal Selection, Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, University of Liege, Belgium.
authors.forename: Etienne
authors.initials: E
authors.lastname: Baise
authors.affiliation: Department of Pathology, Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, University of Liege, Belgium.
authors.forename: Dominique
authors.initials: D
authors.lastname: Cassart
authors.affiliation: (g)Large Animal Internal Medicine, Ghent University, Belgium.
authors.forename: Gunther
authors.initials: G
authors.lastname: van Loon
authors.affiliation: (h)Réseau d'EpidémioSurveillance en Pathologie Equine (RESPE), Caen, France.
authors.forename: Christel
authors.initials: C
authors.lastname: Marcillaud-Pitel
authors.affiliation: (i)Equine Pole, Fundamental and Applied Research for Animals and Health (FARAH), Faculty of Veterinary Medicine, University of Liege, Belgium. Electronic address: dominique.votion@ulg.ac.be.
authors.forename: Dominique-M
authors.initials: DM
authors.lastname: Votion
mesh_terms: D031002:Acer / Q000737:chemistry; D000821:Animal Feed; D000818:Animals; D002331:Carnitine / Q000031:analogs & derivatives / Q000097:blood; D005060:Europe; D005260:Female; D006734:Horse Diseases / Q000139:chemically induced* / Q000473:pathology*; D006736:Horses; D007005:Hypoglycins / Q000633:toxicity; D008297:Male; D028361:Mitochondrial Diseases / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary*; D009132:Muscles / Q000473:pathology; D009135:Muscular Diseases / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary*; D010085:Oxidative Phosphorylation
chemical_list: D007005:Hypoglycins; C116917:acylcarnitine; C041757:hypoglycin; D002331:Carnitine
keywords: Acer; Acylcarnitines; High-resolution respirometry; Horse; Methylenecyclopropyl acetic acid-CoA; Rhabdomyolysis; Skeletal muscle