title: Decreased neural response for facial emotion processing in subjects with high genetic load for schizophrenia.
abstract: Patients with schizophrenia show impairment in facial emotion processing which is essential for successful social cognition. Using a functional magnetic resonance imaging (fMRI), this study aimed to investigate the implicit facial emotion recognition processing in participants with high genetic load for schizophrenia (GHR) as a possible trait marker of developing schizophrenia.
  
  
  
  Block design fMRI of implicit facial emotion processing was used in 20 participants with GHR aged 16-35, and 17 age, sex, and education year-matched healthy controls (HC). During the facial emotional processing for fearful, happy, and neutral face stimuli, participants were asked to explicitly determine the gender per stimuli.
  
  
  
  Occipito-temporo-limbic area in fearful face condition and involvement of broader region including prefrontal cortex in neutral face condition revealed significant attenuation of BOLD signal activation in GHR compared to HC. The GHR demonstrated less activity in right amygdala during fearful and neutral face condition.
  
  
  
  The study presented that GHR displayed abnormal brain activity in occipito-temporo-limbic-frontal network implicated in facial emotion processing. It indicates that abnormal facial emotion processing may be influenced by a genetic factor and could be a trait marker in schizophrenia.
authors.affiliation: Department of Psychiatry, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
authors.forename: Hye Yoon
authors.initials: HY
authors.lastname: Park
authors.affiliation: Department of Psychiatry, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
authors.forename: Je-Yeon
authors.initials: JY
authors.lastname: Yun
authors.affiliation: Institute of Human Behavioral Medicine, SNU-MRC, Seoul 03080, Republic of Korea.
authors.forename: Na Young
authors.initials: NY
authors.lastname: Shin
authors.affiliation: Department of Brain & Cognitive Sciences, College of Natural Science, Seoul National University, Seoul 03080, Republic of Korea.
authors.forename: So-Yeon
authors.initials: SY
authors.lastname: Kim
authors.affiliation: Institute of Human Behavioral Medicine, SNU-MRC, Seoul 03080, Republic of Korea.
authors.forename: Wi Hoon
authors.initials: WH
authors.lastname: Jung
authors.affiliation: Department of Brain & Cognitive Sciences, College of Natural Science, Seoul National University, Seoul 03080, Republic of Korea.
authors.forename: Ye Seul
authors.initials: YS
authors.lastname: Shin
authors.affiliation: Department of Brain & Cognitive Sciences, College of Natural Science, Seoul National University, Seoul 03080, Republic of Korea.
authors.forename: Kang Ik K
authors.initials: KI
authors.lastname: Cho
authors.affiliation: Department of Brain & Cognitive Sciences, College of Natural Science, Seoul National University, Seoul 03080, Republic of Korea.
authors.forename: Youngwoo Bryan
authors.initials: YB
authors.lastname: Yoon
authors.affiliation: Department of Psychiatry, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
authors.forename: Kyung-Ok
authors.initials: KO
authors.lastname: Lim
authors.affiliation: Department of Psychiatry, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
authors.forename: Sung Nyun
authors.initials: SN
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; Institute of Human Behavioral Medicine, SNU-MRC, Seoul 03080, Republic of Korea; Department of Brain & Cognitive Sciences, College of Natural Science, Seoul National University, Seoul 03080, Republic of Korea. Electronic address: kwonjs@snu.ac.kr.
authors.forename: Jun Soo
authors.initials: JS
authors.lastname: Kwon
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging*; D001931:Brain Mapping; D016022:Case-Control Studies; D005149:Facial Expression; D005239:Fear; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D019964:Mood Disorders / Q000209:etiology*; D010100:Oxygen / Q000097:blood; D010775:Photic Stimulation; D012559:Schizophrenia / Q000150:complications / Q000235:genetics / Q000473:pathology; D012565:Schizophrenic Psychology; D055815:Young Adult
chemical_list: D010100:Oxygen
keywords: Amygdala; Facial emotion processing; First-degree relatives; Functional magnetic resonance imaging; Schizophrenia