title: The adhesion GPCR latrophilin - a novel signaling cascade in oriented cell division and anterior-posterior polarity.
abstract: Although several signaling pathways in oriented cell division have been well characterized such as delta/notch inductions or wnt/frizzled-based anterior-posterior polarity, there is strong evidence for additional signal pathways controlling early anterior-posterior polarity decisions. The homolog of the adhesion G protein-coupled receptor latrophilin, LAT-1 has been identified as a receptor essential for oriented cell division in an anterior-posterior direction of specific blastomeres in the early C. elegans embryo. We recently conducted a study aiming at clarifying the signals involved in LAT-1 function. We identified a Gs protein/adenylyl cyclase/cAMP pathway in vitro and demonstrated its physiological relevance in oriented cell division. By interaction with a Gs protein LAT-1 elevates cAMP levels. These data indicate that G-protein signaling in oriented cell division is not solely GPCR-independent. This commentary will discuss our findings in the context of the current knowledge of mechanisms controlling oriented cell division and anterior-posterior polarity. Further, we identify open questions which need to be addressed in the future.
authors.affiliation: Institute of Biochemistry, Molecular Biochemistry, Medical Faculty, Leipzig University , Leipzig, Germany.
authors.forename: Jana
authors.initials: J
authors.lastname: Winkler
authors.affiliation: Institute of Biochemistry, Molecular Biochemistry, Medical Faculty, Leipzig University , Leipzig, Germany.
authors.forename: Simone
authors.initials: S
authors.lastname: Prömel
keywords: G protein-coupled receptor; early C. elegans embryo; latrophilin; signaling pathway; spindle orientation