title: Effect of Ubiquinol on Serum Reproductive Hormones of Amenorrhic Patients.
abstract: In neuroendocrine system the increase in oxidative status is produced by a glucocorticoid-dependent and transcriptional increase in pro-oxidative drive, with concurrent inhibition of the antioxidant defense system, ultimately leading to increased neuronal cell death. Functional hypothalamic disturbances and neuroendocirne aberrations have both short and long term consequences for reproductive health. Understandably, an impaired or diminished hypothalamic-pituitary-ovarian axis leads to anovulation and hypoestrogenism. Anovulation is directly linked to the neurohormonal and hormonal background of Functional Hypothalamic Amenorrhea. Impairment of pulsatile Gonadotropin Releasing Hormone secretion causes the impairment of pulsatile Lutenizing Hormone (LH) and Follicle Stimulating Hormone (FSH) secretion. The importance of oxidative stress in various pituitary disorders suggesting a possible clinical usefulness of antioxidant molecules like the lipophilic antioxidant Ubiquinol. Coenzyme Q10 or Ubiquinol is an essential part of the cell energy-producing system of mitochondria. However, it is also a powerful lipophilic antioxidant, protecting lipoproteins and cell membranes from autooxidation. Due to these unique actions Ubiquinol is used in clinical practice as an antioxidants for neurodegenerative diseases. So to identify the role of Ubiquinol on reproductive hormones FSH and LH, we have included 50 infertile patients of age group of 20-40, which are mostly amenorrhic. Out of 50 only 30 patients were in continuous follow up after supplementing them with 150 mg of Ubiquinol every day for 4 months. The hormonal levels were estimated by Enzyme Linked Immuno Sorbent Assay technique at follicular phase. The result suggests that FSH concentration is increased up to three times (from 3.10 ± 2.70 to 10.09 ± 6.93) but remains within the normal limit (P < 0.05). LH values were found doubled (P < 0.05) than its normal range (from 14.83 ± 10.48 to 27.85 ± 22.30). The Prolactin values were decreased while Progesterone values were high but not in the significant range (P > 0.05). The supplementation of 150 mg of Ubiquinol may reduce the oxidative stress in neuroendocrine system which further improves the function of diminished HPA axis. Hence increased level of FSH and LH may be due to reduced oxidative stress by Ubiquinol.
authors.affiliation: Department of Biochemistry, Lt. BRKM Govt. Medical College, Jagdalpur (C.G), Dimrapal, Jagdalpur, Chhattisgarh 494001 India.
authors.forename: A S
authors.initials: AS
authors.lastname: Thakur
authors.affiliation: Department of Biochemistry, Biology and Genetics, Polytechnique University of the Marche, Ancona, Italy.
authors.forename: G P
authors.initials: GP
authors.lastname: Littaru
authors.affiliation: Kaneka Corporation, Osaka, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Funahashi
authors.affiliation: Lt. BRKM Govt. Medical College, Jagdalpur (C.G), Jagdalpur, India.
authors.forename: U S
authors.initials: US
authors.lastname: Painkara
authors.affiliation: Department of Biochemistry, Lt. BRKM Govt. Medical College, Jagdalpur (C.G), Dimrapal, Jagdalpur, Chhattisgarh 494001 India.
authors.forename: N S
authors.initials: NS
authors.lastname: Dange
authors.affiliation: Department of Gynecology, Lt. BRKM Govt. Medical College, Jagdalpur (C.G), Jagdalpur, India.
authors.forename: P
authors.initials: P
authors.lastname: Chauhan
keywords: Follicular phase; Functional Hypothalamic Amenorrhea (FHA); Hypothalamic–Pituitary–Ovarian axis (HPA axis); Lipophilic antioxidant; Ubiquinol