title: Multi-target siRNA: Therapeutic Strategy for Hepatocellular Carcinoma.
abstract: Multiple targets RNAi strategy is a preferred way to treat multigenic diseases, especially cancers. In the study, multi-target siRNAs were designed to inhibit NET-1, EMS1 and VEGF genes in hepatocellular carcinoma (HCC) cells. And multi-target siRNAs showed better silencing effects on NET-1, EMS1 and VEGF, compared with single target siRNA. Moreover, multi-target siRNA showed greater suppression effects on proliferation, migration, invasion, angiogenesis and induced apoptosis in HCC cells. The results suggested that multi-target siRNA might be a preferred strategy for cancer therapy and NET-1, EMS1 and VEGF could be effective targets for HCC treatments.
authors.affiliation: 1. Department of Pathological Anatomy, Nantong University, Nantong, China;; 2. Small RNA Technology and Application Institute, Nantong University, Nantong, China;; 3. Biomics Biotechnologies Co., Ltd., Nantong, China.
authors.forename: Tiejun
authors.initials: T
authors.lastname: Li
authors.affiliation: 1. Department of Pathological Anatomy, Nantong University, Nantong, China;
authors.forename: Yuwen
authors.initials: Y
authors.lastname: Xue
authors.affiliation: 1. Department of Pathological Anatomy, Nantong University, Nantong, China;
authors.forename: Guilan
authors.initials: G
authors.lastname: Wang
authors.affiliation: 1. Department of Pathological Anatomy, Nantong University, Nantong, China;
authors.forename: Tingting
authors.initials: T
authors.lastname: Gu
authors.affiliation: 1. Department of Pathological Anatomy, Nantong University, Nantong, China;
authors.forename: Yunlong
authors.initials: Y
authors.lastname: Li
authors.affiliation: 2. Small RNA Technology and Application Institute, Nantong University, Nantong, China;; 3. Biomics Biotechnologies Co., Ltd., Nantong, China.
authors.forename: York Yuanyuan
authors.initials: YY
authors.lastname: Zhu
authors.affiliation: 1. Department of Pathological Anatomy, Nantong University, Nantong, China;
authors.forename: Li
authors.initials: L
authors.lastname: Chen
keywords: EMS1; NET-1; VEGF.; hepatocellular carcinoma (HCC); multi-target siRNA