title: Characteristic adaptations of the extracellular matrix in dilated cardiomyopathy.
abstract: Dilated cardiomyopathy (DCM) is a relatively common heart muscle disease characterized by the dilation and thinning of the left ventricle accompanied with left ventricular systolic dysfunction. Myocardial fibrosis is a major feature in DCM and therefore it is inevitable that corresponding extracellular matrix (ECM) changes are involved in DCM onset and progression. Increasing our understanding of how ECM adaptations are involved in DCM could be important for the development of future interventions. This review article discusses the molecular adaptations in ECM composition and structure that have been reported in both animal and human studies of DCM. Furthermore, we provide a transcriptome-based catalogue of ECM genes that are associated with DCM, generated by using NCBI Gene Expression Omnibus database sets for DCM. Based on this in silico analysis, many novel ECM components involved in DCM are identified and discussed in this review. With the information gathered, we propose putative pathways of ECM adaptations in onset and progression of DCM.
authors.affiliation: Department of Nephrology and Hypertension, Division of Internal Medicine and Dermatology, University Medical Center Utrecht, The Netherlands; Netherlands Heart Institute, University Medical Center Utrecht, The Netherlands.
authors.forename: Laura
authors.initials: L
authors.lastname: Louzao-Martinez
authors.affiliation: Department of Pathology, University Medical Center Utrecht, The Netherlands.
authors.forename: Aryan
authors.initials: A
authors.lastname: Vink
authors.affiliation: Netherlands Heart Institute, University Medical Center Utrecht, The Netherlands; Department of Pathology, University Medical Center Utrecht, The Netherlands; Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, The Netherlands.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Harakalova
authors.affiliation: Netherlands Heart Institute, University Medical Center Utrecht, The Netherlands; Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, The Netherlands; Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, United Kingdom.
authors.forename: Folkert W
authors.initials: FW
authors.lastname: Asselbergs
authors.affiliation: Department of Nephrology and Hypertension, Division of Internal Medicine and Dermatology, University Medical Center Utrecht, The Netherlands.
authors.forename: Marianne C
authors.initials: MC
authors.lastname: Verhaar
authors.affiliation: Department of Nephrology and Hypertension, Division of Internal Medicine and Dermatology, University Medical Center Utrecht, The Netherlands; Department of Cardiology, Thoraxcenter, Division of Experimental Cardiology, Erasmus University Medical Center Rotterdam, The Netherlands. Electronic address: K.L.Cheng-2@umcutrecht.nl.
authors.forename: Caroline
authors.initials: C
authors.lastname: Cheng
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D002311:Cardiomyopathy, Dilated / Q000378:metabolism* / Q000473:pathology; D005109:Extracellular Matrix / Q000378:metabolism* / Q000473:pathology; D006801:Humans
keywords: Animal models; Dilated cardiomyopathy (DCM); Extracellular matrix (ECM); Matrisome; Myocardial fibrosis; Transcriptome