title: Axon diameter relates to synaptic bouton size: structural properties define computationally different types of cortical connections in primates.
abstract: Neural connections are implemented by axons of different diameters, whose spectrum increases depending on species and areas. Axon diameter determines conduction velocity and is proportional to the size of the cell body of origin. We describe that in motor, callosal connections of the monkey thick axons distribute larger boutons than thin axons, suggesting that faster axons also release more neurotransmitter at their termination, probably activating more powerfully their targets.
authors.affiliation: Department of Neuroscience, Karolinska Institutet, Retzius Väg 8, Solna, 17177, Stockholm, Sweden. giorgio.innocenti@ki.se.|Brain and Mind Institute, EPFL, Lausanne, Switzerland. giorgio.innocenti@ki.se.
authors.forename: Giorgio M
authors.initials: GM
authors.lastname: Innocenti
authors.affiliation: Department of Physiology and Pharmacology, University of Rome SAPIENZA, Rome, Italy.|Department of Anatomy, Histology, Forensic Medicine and Orthopedics, University of Rome Sapienza, Rome, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Caminiti
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D001710:Biotin / Q000031:analogs & derivatives / Q000378:metabolism; D002540:Cerebral Cortex / Q000166:cytology* / Q000502:physiology; D003196:Computer Graphics; D003337:Corpus Callosum / Q000166:cytology / Q000502:physiology*; D003911:Dextrans / Q000378:metabolism; D008252:Macaca fascicularis; D008297:Male; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology*; D017729:Presynaptic Terminals / Q000145:classification*
chemical_list: D003911:Dextrans; C076397:biotinylated dextran amine; D001710:Biotin
keywords: Axonal phenotype; Computational neuroanatomy; Corpus callosum; Cortex; Motor; Synapses