title: Effect of resorption rate and osteoconductivity of biodegradable calcium phosphate materials on the acquisition of natural bone strength in the repaired bone.
abstract: The purpose of this study was to compare the biodegradation rate and quality of regenerated bone among four materials. A short time period of 8 weeks was chosen to examine early bone healing. The rod-shaped implants of commercially available two β-tricalcium phosphate (β-TCP) ceramics with porosity 60% and 71-80%, respectively, laboratory prepared octacalcium phosphate/gelatin composite (OCP/Gel), which has been proven to have a highly osteoconductive and biodegradable property in rat calvarial defect, and gelatin sponge (Gelatin) were implanted in rabbit tibia defect of 6 mm diameter and 7 mm depth for 2, 4 and 8 weeks. Analyses by μCT, histomorphometry and push-in test were carried out to evaluate the extent of the tissue regeneration and the material biodegradation in the long bone. OCP/Gel and Gelatin were completely resorbed but only OCP/Gel induced cortical bone bridge until 8 weeks that has strength compatible to that of the natural bone. β-TCP (71%-80%) and β-TCP (60%) were not completely resorbed and never induced the amount of new bone formation beyond that by OCP/Gel. The results indicate that the new bone having enough strength could be regenerated if the material shows not only higher biodegradation rate but also higher osteoconductivity. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2833-2842, 2016.
authors.affiliation: Department of Orthopaedic Surgery, Tohoku University School of Medicine, Sendai, 980-8574, Japan.|Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry, Sendai, 980-8575, Japan.
authors.forename: Shinpei
authors.initials: S
authors.lastname: Chiba
authors.affiliation: Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry, Sendai, 980-8575, Japan.
authors.forename: Takahisa
authors.initials: T
authors.lastname: Anada
authors.affiliation: Department of Orthopaedic Surgery, Tohoku University School of Medicine, Sendai, 980-8574, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Suzuki
authors.affiliation: Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry, Sendai, 980-8575, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Saito
authors.affiliation: Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry, Sendai, 980-8575, Japan.
authors.forename: Yukari
authors.initials: Y
authors.lastname: Shiwaku
authors.affiliation: Tohoku Orthopaedic Clinic, Sendai, 981-3121, Japan.
authors.forename: Naohisa
authors.initials: N
authors.lastname: Miyatake
authors.affiliation: Department of Orthopaedic Surgery, Tohoku University School of Medicine, Sendai, 980-8574, Japan.
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Baba
authors.affiliation: Department of Orthopedic Surgery, Osaki Citizen Hospital, Osaki, 989-6183, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Imaizumi
authors.affiliation: Department of Orthopaedic Surgery, Tohoku University School of Medicine, Sendai, 980-8574, Japan.
authors.forename: Masami
authors.initials: M
authors.lastname: Hosaka
authors.affiliation: Department of Orthopaedic Surgery, Tohoku University School of Medicine, Sendai, 980-8574, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Itoi
authors.affiliation: Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry, Sendai, 980-8575, Japan. suzuki-o@m.tohoku.ac.jp.
authors.forename: Osamu
authors.initials: O
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects*; D018786:Bone Substitutes / Q000737:chemistry / Q000494:pharmacology*; D001842:Bone and Bones / Q000187:drug effects / Q000502:physiology; D002130:Calcium Phosphates / Q000737:chemistry / Q000494:pharmacology*; D005780:Gelatin / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D008422:Materials Testing; D016062:Porosity; D011817:Rabbits; D013977:Tibia / Q000187:drug effects / Q000502:physiology
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; C485817:beta-tricalcium phosphate; C022045:octacalcium phosphate; D005780:Gelatin
keywords: bone strength; octacalcium phosphate/gelatin composite; osteoconductivity; resorption rate; β-tricalcium phosphate