title: Site-selective incorporation and ligation of protein aldehydes.
abstract: The incorporation of aldehyde handles into proteins, and subsequent chemical reactions thereof, is rapidly proving to be an effective way of generating homogeneous, covalently linked protein constructs that can display a vast array of functionality. In this review, we discuss methods for introducing aldehydes into target proteins, and summarise the ligation strategies for site-selective modification of proteins containing this class of functional handles.
authors.affiliation: Department of Chemistry, University of York, Heslington Road, York, YO10 5DD, UK. martin.fascione@york.ac.uk.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Spears
authors.affiliation: Department of Chemistry, University of York, Heslington Road, York, YO10 5DD, UK. martin.fascione@york.ac.uk.
authors.forename: Martin A
authors.initials: MA
authors.lastname: Fascione
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D011506:Proteins / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D011506:Proteins