title: Untargeted Metabolomics Reveals Intervention Effects of Total Turmeric Extract in a Rat Model of Nonalcoholic Fatty Liver Disease.
abstract: Nonalcoholic fatty liver disease (NAFLD) is one of the most common forms of chronic liver disease. Currently, there are no recognized medical therapies effective for NAFLD. Previous studies have demonstrated the effects of total turmeric extract on rats with NAFLD induced by high-fat diet. In this study, serum metabolomics was employed using UHPLC-Q-TOF-MS to elucidate the underlying mechanisms of HFD-induced NAFLD and the therapeutic effects of TE. Supervised orthogonal partial least-squares-discriminant analysis was used to discover differentiating metabolites, and pathway enrichment analysis suggested that TE had powerful combined effects of regulating lipid metabolism by affecting glycerophospholipid metabolism, glycerolipid metabolism, and steroid hormone biosynthesis signaling pathways. In addition, the significant changes in glycerophospholipid metabolism proteins also indicated that glycerophospholipid metabolism might be involved in the therapeutic effect of TE on NAFLD. Our findings not only supply systematic insight into the mechanisms of NAFLD but also provide a theoretical basis for the prevention or treatment of NAFLD.
authors.affiliation: Pharmacy College, Jinzhou Medical University, Jinzhou 121000, China; China Military Institute of Chinese Medicine, 302 Military Hospital, Beijing 100039, China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Wang
authors.affiliation: China Military Institute of Chinese Medicine, 302 Military Hospital, Beijing 100039, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Niu
authors.affiliation: China Military Institute of Chinese Medicine, 302 Military Hospital, Beijing 100039, China.
authors.forename: Ge-Liu-Chang
authors.initials: GL
authors.lastname: Jia
authors.affiliation: Animal Laboratory Center, 302 Hospital of PLA, Beijing 100039, China.
authors.forename: Rui-Sheng
authors.initials: RS
authors.lastname: Li
authors.affiliation: China Military Institute of Chinese Medicine, 302 Military Hospital, Beijing 100039, China.
authors.forename: Ya-Ming
authors.initials: YM
authors.lastname: Zhang
authors.affiliation: China Military Institute of Chinese Medicine, 302 Military Hospital, Beijing 100039, China.
authors.forename: Cong-En
authors.initials: CE
authors.lastname: Zhang
authors.affiliation: China Military Institute of Chinese Medicine, 302 Military Hospital, Beijing 100039, China.
authors.forename: Ya-Kun
authors.initials: YK
authors.lastname: Meng
authors.affiliation: China Military Institute of Chinese Medicine, 302 Military Hospital, Beijing 100039, China.
authors.forename: He-Rong
authors.initials: HR
authors.lastname: Cui
authors.affiliation: Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
authors.forename: Zhi-Jie
authors.initials: ZJ
authors.lastname: Ma
authors.affiliation: Pharmacy College, Jinzhou Medical University, Jinzhou 121000, China.
authors.forename: Dong-Hui
authors.initials: DH
authors.lastname: Li
authors.affiliation: China Military Institute of Chinese Medicine, 302 Military Hospital, Beijing 100039, China.
authors.forename: Jia-Bo
authors.initials: JB
authors.lastname: Wang
authors.affiliation: China Military Institute of Chinese Medicine, 302 Military Hospital, Beijing 100039, China.
authors.forename: Xiao-He
authors.initials: XH
authors.lastname: Xiao