title: Brainstem micro-abscesses caused by Burkholderia pseudomallei in a 10-month-old infant: a case report.
abstract: Melioidosis is an uncommon tropical infectious disease caused by Burkholderia pseudomallei. Neurological complications of melioidosis are extremely uncommon in infants. A 10-month-old girl is described who presented with disseminated melioidosis with subcutaneous nodules, arthritis, hepatomegaly and a lung cavity, and developed a left medial rectus palsy. Cranial MRI demonstrated mid-brain, pontine and basal ganglia micro-abscesses. Therapy with meropenem and cotrimoxazole led to resolution of the medial nerve palsy. At 5-month follow-up, the child had no residual neurological deficits.
authors.affiliation: a Department of Paediatrics , Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) , Pondicherry , India.
authors.forename: M
authors.initials: M
authors.lastname: Prasanna Kumar
authors.affiliation: a Department of Paediatrics , Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) , Pondicherry , India.
authors.forename: Sriram
authors.initials: S
authors.lastname: Krishnamurthy
authors.affiliation: a Department of Paediatrics , Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) , Pondicherry , India.
authors.forename: V S
authors.initials: VS
authors.lastname: Venkateswaran
authors.affiliation: a Department of Paediatrics , Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) , Pondicherry , India.
authors.forename: Subramanian
authors.initials: S
authors.lastname: Mahadevan
authors.affiliation: a Department of Paediatrics , Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) , Pondicherry , India.
authors.forename: M
authors.initials: M
authors.lastname: Lalitha
authors.affiliation: b Department of Microbiology , Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) , Pondicherry , India.
authors.forename: Sujatha
authors.initials: S
authors.lastname: Sistla
authors.affiliation: c Department of Radiodiagnosis , Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) , Pondicherry , India.
authors.forename: K
authors.initials: K
authors.lastname: Nagarajan
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D001921:Brain / Q000000981:diagnostic imaging; D001922:Brain Abscess / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology*; D001933:Brain Stem / Q000473:pathology*; D016957:Burkholderia pseudomallei / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008554:Melioidosis / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D000077731:Meropenem; D013845:Thienamycins / Q000008:administration & dosage; D016896:Treatment Outcome; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage
chemical_list: D000900:Anti-Bacterial Agents; D013845:Thienamycins; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D000077731:Meropenem
keywords: Brainstem micro-abscesses; Burkholderia pseudomallei; Infant; Melioidosis; Neuromelioidosis