title: Intralipid Emulsion Rescue Therapy: Emerging Therapeutic Indications in Medical Practice.
abstract: Intralipid emulsion therapy is well-established for the treatment of local-anesthetic systemic toxicities. In recent years, its role has expanded as an important therapeutic agent in the reversal of other types of drug overdoses, including certain types of antipsychotics, antidepressants, antiarrhythmics, and calcium channel blockers. A literature review identified thirty-one case reports including forty-nine separate drug overdose cases involving ten separate drug classes which were successfully reversed with Intralipid. The present clinical case study describes an elderly unresponsive woman refractory to conventional treatments after ingesting a potentially lethal amount of 5.6 grams of diltiazem in a suicide attempt. After treatment with Intralipid over a twenty-four hour period, the patient's hemodynamic and metabolic derangements were corrected and stabilized completely. Intralipid emulsion rescue therapy provides another potential strategy for the reversal of many drug toxicities, most likely by providing a lipid layer safety net for drug overdose by passive diffusion. Clinicians are urged to embrace an expanded role of Intralipid emulsion rescue therapy, not only for local anesthetic drug toxicities, but also for other lipophilic drug overdoses.
authors.affiliation: School of Medicine, Department of Anesthesiology, Louisiana State University Health Sciences Center, New Orleans.
authors.forename: Sam H
authors.initials: SH
authors.lastname: Muller
authors.affiliation: School of Medicine, Department of Anesthesiology, Louisiana State University Health Sciences Center, New Orleans.|School of Public Health, Louisiana State University Health Sciences Center, New Orleans.
authors.forename: James H
authors.initials: JH
authors.lastname: Diaz
authors.affiliation: School of Medicine, Department of Anesthesiology, Louisiana State University Health Sciences Center, New Orleans.|School of Medicine, Department of Pharmacology, Louisiana State University Health Sciences Center, New Orleans.
authors.forename: Alan David
authors.initials: AD
authors.lastname: Kaye
mesh_terms: D000369:Aged, 80 and over; D004110:Diltiazem / Q000506:poisoning*; D062787:Drug Overdose / Q000628:therapy*; D004638:Emergency Treatment; D004655:Emulsions / Q000008:administration & dosage; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D010743:Phospholipids / Q000008:administration & dosage*; D013024:Soybean Oil / Q000008:administration & dosage*; D013406:Suicide, Attempted
chemical_list: D004655:Emulsions; D005217:Fat Emulsions, Intravenous; D010743:Phospholipids; C545823:soybean oil, phospholipid emulsion; D013024:Soybean Oil; D004110:Diltiazem