title: Haploidentical peripheral blood stem cell transplantation with posttransplant cyclophosphamide in children and adolescents with hematological malignancies.
abstract: Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) using posttransplant cyclophosphamide (Cy) for graft versus host disease (GVHD) prophylaxis has emerged as an alternative transplant strategy for patients without related donors, especially in the setting of limited resources in which T-cell ex vivo depletion is not affordable. Experience with this transplant modality in children and adolescents is limited.
  
  
  
  We report a retrospective analysis of 25 consecutive outpatients under 21 years of age with high-risk hematological malignancies, who received a haplo-HSCT using posttransplant Cy as GVHD prophylaxis.
  
  
  
  Twenty-three (92%) of the 25 patients engrafted, and 20 (95%) of 21 evaluable subjects achieved full donor chimerism by day +30. One-year estimated overall survival and event-free survival were 50% and 33%, respectively. The cumulative incidence rate of severe acute GVHD was 19%, and 15% of patients developed chronic GVHD.
  
  
  
  Haplo-HSCT with posttransplant Cy is a feasible therapeutic option for children and adolescents with high-risk hematological malignancies in a limited resource setting.
authors.affiliation: Hematology Service, Hospital Universitario "Dr. Jose E. Gonzalez," Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México.
authors.forename: Oscar
authors.initials: O
authors.lastname: González-Llano
authors.affiliation: Hematology Service, Hospital Universitario "Dr. Jose E. Gonzalez," Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México.
authors.forename: Elías Eugenio
authors.initials: EE
authors.lastname: González-López
authors.affiliation: Hematology Service, Hospital Universitario "Dr. Jose E. Gonzalez," Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México.
authors.forename: Ana Carolina
authors.initials: AC
authors.lastname: Ramírez-Cázares
authors.affiliation: Hematology Service, Hospital Universitario "Dr. Jose E. Gonzalez," Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México.
authors.forename: Edson René
authors.initials: ER
authors.lastname: Marcos-Ramírez
authors.affiliation: Clínica Ruiz de Puebla, Puebla, México.
authors.forename: Guillermo José
authors.initials: GJ
authors.lastname: Ruiz-Argüelles
authors.affiliation: Hematology Service, Hospital Universitario "Dr. Jose E. Gonzalez," Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México. dgomezalmaguer@gmail.com.
authors.forename: David
authors.initials: D
authors.lastname: Gómez-Almaguer
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000627:therapeutic use*; D005260:Female; D006086:Graft vs Host Disease / Q000453:epidemiology; D019337:Hematologic Neoplasms / Q000401:mortality / Q000628:therapy*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D036102:Peripheral Blood Stem Cell Transplantation; D012189:Retrospective Studies; D018183:Transplantation Chimera; D019172:Transplantation Conditioning
chemical_list: D003520:Cyclophosphamide
keywords: haploidentical; peripheral blood stem cells; posttransplant cyclophosphamide