title: Design, synthesis and anticancer activity of novel hybrid compounds between benzofuran and N-aryl piperazine.
abstract: A series of novel hybrid compounds between benzofuran and N-aryl piperazine have been designed and prepared. These derivatives were evaluated for their in vitro anti-tumor activity against a panel of human tumor cell lines by MTT assay. The results demonstrated that amide derivatives were more bioactive than sulfonamide compounds in general, and that chloro or trifluoromethyl substituent was vital for modulating cytotoxic activity. In particular, compound 13 was found to be the most potent compound against 4 strains human tumor cell lines, and exhibited cytotoxic activity selectively against Hela (0.03μM).
authors.affiliation: School of Traditional Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500, PR China.
authors.forename: Ze-Wei
authors.initials: ZW
authors.lastname: Mao
authors.affiliation: Central Laboratory, The No. 1 Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, Kunming 650021, PR China.
authors.forename: Xi
authors.initials: X
authors.lastname: Zheng
authors.affiliation: School of Traditional Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500, PR China.
authors.forename: Yu-Ping
authors.initials: YP
authors.lastname: Lin
authors.affiliation: School of Traditional Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500, PR China.
authors.forename: Chun-Yan
authors.initials: CY
authors.lastname: Hu
authors.affiliation: School of Traditional Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500, PR China.
authors.forename: Xiu-Li
authors.initials: XL
authors.lastname: Wang
authors.affiliation: Central Laboratory, The No. 1 Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, Kunming 650021, PR China. Electronic address: wanchunping1012@163.com.
authors.forename: Chun-Ping
authors.initials: CP
authors.lastname: Wan
authors.affiliation: School of Traditional Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500, PR China. Electronic address: rao13987124569@qq.com.
authors.forename: Gao-Xiong
authors.initials: GX
authors.lastname: Rao
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001572:Benzofurans / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D000077489:Piperazine; D010879:Piperazines / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D001572:Benzofurans; D010879:Piperazines; D000077489:Piperazine; C105430:benzofuran
keywords: Anticancer activity; Benzofuran; Hybrid compounds; N-Aryl piperazine