title: Accelerated chemical shift imaging of hyperpolarized (13) C metabolites.
abstract: Chemical shift imaging (CSI) has long been considered the gold standard method for in vivo hyperpolarized (13) C metabolite imaging because of its high sensitivity. However, CSI requires a large number of excitations so it is desirable to reduce the number of RF excitations and the total acquisition time.
  
  
  
  Centric phase encoding and three-dimensional compressed sensing methods were adopted into a CSI acquisition to improve efficiency and reduce the number of excitations required for imaging hyperpolarized metabolites. The new method was implemented on a GE MR750W scanner for routine real time metabolic imaging experiments.
  
  
  
  Imaging results from phantoms and in vivo animals using hyperpolarized (13) C tracers demonstrate that when the entire CSI dataset is treated as a single object, compressed sensing can be satisfactorily applied to spectroscopic CSI. Centric k-space trajectory data collection also greatly improves the acquisition efficiency. This combination of compressed sensing CSI and acquisition time reduction was used to perform a hyperpolarized (13) C dynamic study.
  
  
  
  Compressed sensing can be satisfactorily applied to conventional CSI in hyperpolarized (13) C metabolite MR imaging to reduce the number of RF excitations and accelerate the imaging speed to take advantage of conventional CSI in providing high sensitivity and a large spectral bandwidth. Magn Reson Med 76:1033-1038, 2016. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA. jian-xiong.wang@utsouthwestern.edu.|Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. jian-xiong.wang@utsouthwestern.edu.
authors.forename: Jian-Xiong
authors.identifier: 0000-0002-3862-2679
authors.initials: JX
authors.lastname: Wang
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, USA.
authors.forename: Matthew E
authors.initials: ME
authors.lastname: Merritt
authors.affiliation: Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA.|Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.|Department of Chemistry, University of Texas at Dallas, Richardson, Texas, USA.
authors.forename: A Dean
authors.initials: AD
authors.lastname: Sherry
authors.affiliation: Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA.|Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.|Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.|VA North Texas Health Care System, Dallas, Texas, USA.
authors.forename: Craig R
authors.initials: CR
authors.lastname: Malloy
mesh_terms: D000465:Algorithms; D000818:Animals; D002247:Carbon Isotopes / Q000493:pharmacokinetics*; D066241:Carbon-13 Magnetic Resonance Spectroscopy / Q000379:methods*; D007668:Kidney / Q000378:metabolism*; D019344:Lactic Acid / Q000378:metabolism*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D057054:Molecular Imaging / Q000379:methods; D019289:Pyruvic Acid / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014018:Tissue Distribution
chemical_list: D002247:Carbon Isotopes; D019344:Lactic Acid; D019289:Pyruvic Acid
keywords: chemical shift imaging (CSI); compressed sensing; hyperpolarized 13C MRI; in-vivo MRI