title: Antiatherogenic Roles of Dietary Flavonoids Chrysin, Quercetin, and Luteolin.
abstract: Cardiovascular diseases (CVDs) are the commonest cause of global mortality and morbidity. Atherosclerosis, the fundamental pathological manifestation of CVDs, is a complex process and is poorly managed both in terms of preventive and therapeutic intervention. Aberrant lipid metabolism and chronic inflammation play critical roles in the development of atherosclerosis. These processes can be targeted for effective management of the disease. Although managing lipid metabolism is in the forefront of current therapeutic approaches, controlling inflammation may also prove to be crucial for an efficient treatment regimen of the disease. Flavonoids, the plant-derived polyphenols, are known for their antiinflammatory properties. This review discusses the possible antiatherogenic role of 3 flavonoids, namely, chrysin, quercetin, and luteolin primarily known for their antiinflammatory properties.
authors.affiliation: Department of Molecular Biology and Biotechnology, Tezpur University, Napaam, India.
authors.forename: Anandita
authors.initials: A
authors.lastname: Basu
authors.forename: Anindhya S
authors.initials: AS
authors.lastname: Das
authors.forename: Munmi
authors.initials: M
authors.lastname: Majumder
authors.forename: Rupak
authors.initials: R
authors.lastname: Mukhopadhyay
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D050197:Atherosclerosis / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D001682:Biological Availability; D000072001:Diet, Healthy; D005419:Flavonoids / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D018836:Inflammation Mediators / Q000378:metabolism; D007408:Intestinal Absorption; D050356:Lipid Metabolism / Q000187:drug effects; D047311:Luteolin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D011794:Quercetin / Q000008:administration & dosage* / Q000493:pharmacokinetics
chemical_list: D000893:Anti-Inflammatory Agents; D005419:Flavonoids; D018836:Inflammation Mediators; C043561:chrysin; D011794:Quercetin; D047311:Luteolin