title: Orosomucoid-1 Expression in Ameloblastoma Variants.
abstract: Odontogenic tumors constitute a group of heterogeneous lesions of benign and malignant neoplasms with variable aggressiveness. Ameloblastomas are a group of benign but locally invasive neoplasms that occur in the jaws and are derived from epithelial elements of the tooth-forming apparatus. We previously described orosomucoid-1 protein expression in odontogenic myxomas. However, whether orosomucoid-1 is expressed in other odontogenic tumors remains unknown. Since orosomucoid-1 belongs to a group of acute-phase proteins and has many functions in health and disease, we identified and analyzed orosomucoid-1 expression in ameloblastoma variants and ameloblastic carcinoma using western blot and immunohistochemical techniques. Thirty cases of ameloblastoma were analyzed for orsomucoid-1; five specimens were fresh for western blot study (four benign ameloblastomas and one ameloblastic carcinoma), and 25 cases of benign ameloblastoma for immunohistochemical assays. Orosomucoid-1 was widely expressed in each tumor variant analyzed in this study, and differential orosomucoid-1 expression was observed between benign and malignant tumor. Orosomucoid-1 may play an important role in the behavior of ameloblastomas and influence the biology and development of the variants of this tumor.
authors.affiliation: Laboratorio de Investigación en Odontología, ALMARAZ/UBIMED, FES Iztacala, UNAM. State of Mexico, Mexico.
authors.forename: Alejandro
authors.initials: A
authors.lastname: García-Muñoz
authors.affiliation: Molecular Pathology, Universidad de la República (UDELAR), Montevideo, Uruguay.
authors.forename: Ronell
authors.initials: R
authors.lastname: Bologna-Molina
authors.affiliation: Department of Infectomics and Molecular Pathogenesis, CINVESTAV-IPN, México, D.F, México.
authors.forename: Mario
authors.initials: M
authors.lastname: A Rodríguez
authors.affiliation: Maxillofacial Surgery Department. Hospital Juárez de México, México D.F, México.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Liceága-Reyes
authors.affiliation: Instituto Nacional de Pediatría, México D.F, México.
authors.forename: Jose Eduardo
authors.initials: JE
authors.lastname: Farfán-Morales
authors.affiliation: Biochemistry, Microbiology and Pathology Laboratory, Faculty of Stomatology, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico.
authors.forename: Saray
authors.initials: S
authors.lastname: Aranda-Romo
authors.affiliation: Health Care Department, Universidad Autónoma Metropolitana, Xochimilco, UAM, México City, Mexico.
authors.forename: Nelly
authors.initials: N
authors.lastname: Molina-Frechero
authors.affiliation: Department Research, School of Dentistry, Universidad Juárez del Estado de Durango, México.
authors.forename: Rogelio
authors.initials: R
authors.lastname: González-González
keywords: Orosomucoid-1; ameloblastic carcinoma; ameloblastoma; odontogenic tumors