title: Sexual problems in people with refractory epilepsy.
abstract: Sexual dysfunction is an important but often neglected aspect of epilepsy. The objective of this study was to explore the prevalence and types of sexual problems in patients with epilepsy and compare the results with similar data obtained from a representative sample of the general population. At the National Centre for Epilepsy in Norway, 171 of 227 consecutive adult inpatients and outpatients with epilepsy (response rate: 75.3%) and their neurologists participated in a questionnaire study about epilepsy and sexuality. The results were compared with data available from 594 adult Norwegians who had completed the same questionnaire. Patients with epilepsy had a significantly higher prevalence of sexual problems (women: 75.3% vs. 12.0%; men: 63.3% vs. 9.6%). The most commonly reported problems (>30%) were reduced sexual desire, orgasm problems, erection problems, and vaginal dryness. The patients reported considerable dissatisfaction regarding sexual functioning. Significantly more sexual problems were found in patients of both sexes with reduced quality of life and in women with symptoms of depression. We found no significant association between sexual problems and age of epilepsy onset, type of epilepsy, or use of enzyme-inducing antiepileptic drugs. Whereas age at sexual debut did not differ between the patients with epilepsy and the general population, men with epilepsy had a lower number of partners during the last 12months, and the proportion of women with a low frequency of intercourse was higher in the group with epilepsy. In conclusion, sexual problems are significantly greater in Norwegian patients with epilepsy than in the general adult population. As no single epilepsy type or treatment could be identified as a specific predisposing factor, it seems likely that there are multiple causes underlying our results, including both organic and psychosocial factors.
authors.affiliation: National Centre for Epilepsy, Division of Clinical Neuroscience, Oslo University Hospital, Norway. Electronic address: oliver.henning@ous-hf.no.
authors.forename: Oliver J
authors.initials: OJ
authors.lastname: Henning
authors.affiliation: National Centre for Epilepsy, Division of Clinical Neuroscience, Oslo University Hospital, Norway.
authors.forename: Karl O
authors.initials: KO
authors.lastname: Nakken
authors.affiliation: Department of Psychology, University of Oslo, Norway.
authors.forename: Bente
authors.initials: B
authors.lastname: Træen
authors.affiliation: Department of Pediatrics, Oslo University Hospital, Norway.
authors.forename: Petter
authors.initials: P
authors.lastname: Mowinckel
authors.affiliation: National Centre for Epilepsy, Division of Clinical Neuroscience, Oslo University Hospital, Norway.
authors.forename: Morten
authors.initials: M
authors.lastname: Lossius
mesh_terms: D000328:Adult; D017668:Age of Onset; D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use; D003863:Depression / Q000453:epidemiology / Q000209:etiology; D000069279:Drug Resistant Epilepsy / Q000150:complications* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009664:Norway / Q000453:epidemiology; D015995:Prevalence; D011788:Quality of Life; D012735:Sexual Dysfunction, Physiological / Q000453:epidemiology / Q000209:etiology*; D011795:Surveys and Questionnaires
chemical_list: D000927:Anticonvulsants
keywords: Epilepsy; Quality of life; Sexual dysfunction; Sexual problems