title: Isolation of (-)-14-O-Malonylindolactam-V as a Possible Precursor of (-)-Indolactam-V and (-)-14-O-Acetylindolactam-V from Streptomyces blastmyceticum.
abstract: (-)-Indolactam-V (1) has the fundamental structure of potent tumor-promoting teleocidins. A new teleocidin-related metabolite, (-)-14-O-malonylindolactam-V (2), was isolated from the culture broth of Streptomyces blastmyceticum NA34-17 which produced a large quantity of 1 along with a small amount of (-)-14-O-acetylindolactam-V (3). Heat treatment of 2 in methanol readily produced 1 and 3, suggesting that S. blastmyceticum NA34-17 excreted 1 as a malonic acid conjugate to accumulate 1 and 3 in the culture broth during cultivation.
authors.affiliation: a Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University.
authors.forename: K
authors.initials: K
authors.lastname: Irie
authors.affiliation: a Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University.
authors.forename: S
authors.initials: S
authors.lastname: Tomimatsu
authors.affiliation: a Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University.
authors.forename: Y
authors.initials: Y
authors.lastname: Nakagawa
authors.affiliation: a Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University.
authors.forename: H
authors.initials: H
authors.lastname: Ohigashi
authors.affiliation: b Department of Applied Biological Chemistry, Osaka Prefecture University.
authors.forename: H
authors.initials: H
authors.lastname: Hayashi
keywords: (-)-indolactam-V; Streptomyces blastmyceticum; malonic acid conjugate; teleocidin; tumor promoter