title: Changes in Substance Use Symptoms Across Adolescence in Youth Perinatally Infected with HIV.
abstract: The paper utilizes data collected at three time points in a longitudinal study of perinatally HIV-infected (PHIV+) and a comparison group of perinatally exposed but HIV-uninfected (PHEU) youths in the United States (N = 325). Using growth curve modeling, the paper examines changes in substance use symptoms among PHIV+ and PHEU youths as they transition through adolescence, and assesses the individual and contextual factors associated with the rate of change in substance use symptoms. Findings indicate that substance use symptoms increased over time among PHIV+ youths, but not among PHEU youths. The rate of change in these symptoms was positively associated with an increasing number of negative life events. Study findings underscore the need for early, targeted interventions for PHIV+ youths, and interventions to reduce adversities and their deleterious effects in vulnerable populations.
authors.affiliation: Department of Health Behavior and Biological Sciences, University of Michigan, Ann Arbor, MI, USA. mmutumba@umich.edu.
authors.forename: M
authors.identifier: http://orcid.org/0000-0002-0636-891X
authors.initials: M
authors.lastname: Mutumba
authors.affiliation: HIV Center for Clinical and Behavioral Studies, New York State Psychiatric Institute and Columbia University, New York, NY, USA.
authors.forename: K S
authors.initials: KS
authors.lastname: Elkington
authors.affiliation: Department of Family and Community Health, University of Pennsylvania School of Nursing, 418 Curie Blvd, Philadelphia, PA, 19104, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Bauermeister
authors.affiliation: HIV Center for Clinical and Behavioral Studies, New York State Psychiatric Institute and Columbia University, New York, NY, USA.
authors.forename: A
authors.initials: A
authors.lastname: Bucek
authors.affiliation: HIV Center for Clinical and Behavioral Studies, New York State Psychiatric Institute and Columbia University, New York, NY, USA.
authors.forename: C
authors.initials: C
authors.lastname: Dolezal
authors.affiliation: HIV Center for Clinical and Behavioral Studies, New York State Psychiatric Institute and Columbia University, New York, NY, USA.
authors.forename: C S
authors.initials: CS
authors.lastname: Leu
authors.affiliation: HIV Center for Clinical and Behavioral Studies, New York State Psychiatric Institute and Columbia University, New York, NY, USA.
authors.forename: C A
authors.initials: CA
authors.lastname: Mellins
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D015658:HIV Infections / Q000453:epidemiology* / Q000635:transmission; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D008137:Longitudinal Studies; D008297:Male; D000074609:Marijuana Use / Q000453:epidemiology*; D019966:Substance-Related Disorders / Q000453:epidemiology*; D000066608:Underage Drinking / Q000706:statistics & numerical data*; D014481:United States / Q000453:epidemiology
keywords: Adolescence; Drug use; People living with HIV; Stress