title: Smaller hippocampal volumes predict lower antidepressant response/remission rates in depressed patients: A meta-analysis.
abstract: Whether hippocampal volume predicts response and/or remission after antidepressant treatment of major depressive episodes (MDE) in major depressive disorder (MDD) remains unclear. We meta-analysed prospective studies comparing baseline hippocampal volume in patients with or without response/remission after antidepressant treatment.
  
  
  
  Pubmed, Embase and Google Scholar were searched for studies of patients with current MDE in MDD, with hippocampal volume assessments at baseline, initiation of antidepressant drug treatment, and prospective assessment of response/remission after treatment.
  
  
  
  Six studies (374 patients), of which two were positive and four negative, were meta-analysed. Compared to responders/remitters, patients who failed to achieve response/remission had smaller total hippocampus volumes at baseline (mean volume difference = 260 mm3, 95% CI [93; 427], P = 0.002). These results remained significant in patients under 60 years of age (P = 0.02), in those over 60 years old (P = 0.04), and for right (P = 0.006) and left (P = 0.02) hippocampi. The probability of non-response/non-remission was 68.6% for patients with a total hippocampal volume at least 10% lower than the average, and 47.1% for patients with a total hippocampal volume 10% higher than the average.
  
  
  
  In depressed patients treated with antidepressant drugs, smaller hippocampal volumes predict lower response/remission rates.
authors.affiliation: a INSERM UMR 1178, Team "Depression and Antidepressants", Univ Paris Sud, Service de Psychiatrie, Hôpital Bicêtre, Assistance Publique Hôpitaux de Paris , Le Kremlin Bicêtre , France.
authors.forename: Romain
authors.initials: R
authors.lastname: Colle
authors.affiliation: a INSERM UMR 1178, Team "Depression and Antidepressants", Univ Paris Sud, Service de Psychiatrie, Hôpital Bicêtre, Assistance Publique Hôpitaux de Paris , Le Kremlin Bicêtre , France.
authors.forename: Irène
authors.initials: I
authors.lastname: Dupong
authors.affiliation: b Institut du Cerveau et de la Moelle Épinière, ICM, INSERM, U1127, CNRS, UMR 7225, Sorbonne Universites, UPMC Univ Paris 06, Inria, Aramis Team, Centre de Recherche Paris, Inria Paris-Rocquencourt , Paris , France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Colliot
authors.affiliation: a INSERM UMR 1178, Team "Depression and Antidepressants", Univ Paris Sud, Service de Psychiatrie, Hôpital Bicêtre, Assistance Publique Hôpitaux de Paris , Le Kremlin Bicêtre , France.
authors.forename: Eric
authors.initials: E
authors.lastname: Deflesselle
authors.affiliation: a INSERM UMR 1178, Team "Depression and Antidepressants", Univ Paris Sud, Service de Psychiatrie, Hôpital Bicêtre, Assistance Publique Hôpitaux de Paris , Le Kremlin Bicêtre , France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Hardy
authors.affiliation: c INSERM UMR 1178, Département de Biostatistiques , Univ Paris Sud, Hôpital Paul Brousse, Assistance Publique Hôpitaux de Paris , Villejuif , France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Falissard
authors.affiliation: d CNRS IR4M, UMR 8081, Univ Paris Sud, Neuroradiology Hôpital Bicêtre, Assistance Publique Hôpitaux de Paris , Le Kremlin Bicêtre , France.
authors.forename: Denis
authors.initials: D
authors.lastname: Ducreux
authors.affiliation: b Institut du Cerveau et de la Moelle Épinière, ICM, INSERM, U1127, CNRS, UMR 7225, Sorbonne Universites, UPMC Univ Paris 06, Inria, Aramis Team, Centre de Recherche Paris, Inria Paris-Rocquencourt , Paris , France.
authors.forename: Marie
authors.initials: M
authors.lastname: Chupin
authors.affiliation: a INSERM UMR 1178, Team "Depression and Antidepressants", Univ Paris Sud, Service de Psychiatrie, Hôpital Bicêtre, Assistance Publique Hôpitaux de Paris , Le Kremlin Bicêtre , France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Corruble
mesh_terms: D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000494:pharmacology*; D003865:Major Depressive Disorder / Q000188:drug therapy*; D005260:Female; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care / Q000706:statistics & numerical data*
chemical_list: D000928:Antidepressive Agents
keywords: Hippocampal volume; antidepressant; major depressive episode; meta-analysis; response/remission