title: Increased risk of osteoporosis in patients with erectile dysfunction: A nationwide population-based cohort study.
abstract: In this study, we aimed to investigate the risk of osteoporosis in patients with erectile dysfunction (ED) by analyzing data from the Taiwan National Health Insurance Research Database (NHIRD). From the Taiwan NHIRD, we analyzed data on 4460 patients aged ≥40 years diagnosed with ED between 1996 and 2010. In total, 17,480 age-matched patients without ED in a 1:4 ratio were randomly selected as the non-ED group. The relationship between ED and the risk of osteoporosis was estimated using Cox proportional hazard regression models. During the follow-up period, 264 patients with ED (5.92%) and 651 patients without ED (3.65%) developed osteoporosis. The overall incidence of osteoporosis was 3.04-fold higher in the ED group than in the non-ED group (9.74 vs 2.47 per 1000 person-years) after controlling for covariates. Compared with patients without ED, patients with psychogenic and organic ED were 3.19- and 3.03-fold more likely to develop osteoporosis. Our results indicate that patients with a history of ED, particularly younger men, had a high risk of osteoporosis. Patients with ED should be examined for bone mineral density, and men with osteoporosis should be evaluated for ED.
authors.affiliation: aGraduate Institute of Medicine, College of Medicine bDepartment of Neurosurgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University cDepartment of Dermatology, Kaohsiung Veterans General Hospital dCosmetic Applications and Management Department, Yuh-Ing Junior College of Health Care & Management eGraduate Institute of Medicine, College of Medicine fDepartment of Pathology, Kaohsiung Medical University Hospital gGraduate Institute of Medicine hDepartment of Pathology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University iInstitute of Biomedical Sciences, National Sun Yat-Sen University jDepartment of Neurosurgery, Kaohsiung Medical University Hospital kGraduate Institute of Medicine lDepartment of Neurosurgery, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors.forename: Chieh-Hsin
authors.initials: CH
authors.lastname: Wu
authors.forename: Ying-Yi
authors.initials: YY
authors.lastname: Lu
authors.forename: Chee-Yin
authors.initials: CY
authors.lastname: Chai
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Su
authors.forename: Tai-Hsin
authors.initials: TH
authors.lastname: Tsai
authors.forename: Feng-Ji
authors.initials: FJ
authors.lastname: Tsai
authors.forename: Chih-Lung
authors.initials: CL
authors.lastname: Lin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D007172:Erectile Dysfunction / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000150:complications* / Q000453:epidemiology*; D012189:Retrospective Studies; D018570:Risk Assessment; D013624:Taiwan