title: Potential association of reduced cholinesterase activity with Trypanosoma evansi pathogenesis in buffaloes.
abstract: The present study aimed to investigate the association of cholinesterase activity with trypanosomosis in buffaloes. Thirty-three clinical cases of trypanosomosis in water buffaloes, found positive for trypomastigotes of T. evansi on blood smear examination, were divided into two groups based on clinical manifestations. Twenty diseased buffaloes revealing only common clinical signs were allocated to Group I, while the remaining 13 buffaloes showing common clinical manifestations along with neurological disturbances were allocated to Group II. Twelve clinically healthy buffaloes, free from any haemoprotozoa infection, were kept as healthy control (Group III). Blood samples were collected from buffaloes of all three groups to determine serum cholinesterase activity. Compared to buffaloes of healthy control group, cholinesterase activity in T. evansi-infected buffaloes of Group I and II was significantly (P<0.001) lower. However, no significant difference was observed in cholinesterase activity between the T. evansi-infected buffaloes exhibiting neurological disorders and no neurological disorders. Summing up, reduced cholinesterase activity seems to be associated with the pathogenesis of natural T. evansi infection and its clinical manifestations in buffaloes possibly by evading immune response. Further studies are warranted on association of cholinesterase activity in T. evansi-infected buffaloes with neurological disorders.
authors.affiliation: Department of Veterinary Medicine, College of Veterinary Science and Animal Husbandry, DUVASU, Mathura, 281 001 U.P., India. Electronic address: pshankervet@gmail.com.
authors.forename: Shanker K
authors.initials: SK
authors.lastname: Singh
authors.affiliation: Department of Veterinary Medicine, College of Veterinary Science and Animal Husbandry, DUVASU, Mathura, 281 001 U.P., India.
authors.forename: Vivek K
authors.initials: VK
authors.lastname: Singh
authors.affiliation: Department of Veterinary Medicine, College of Veterinary Science and Animal Husbandry, DUVASU, Mathura, 281 001 U.P., India.
authors.forename: Brajesh K
authors.initials: BK
authors.lastname: Yadav
authors.affiliation: Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, DUVASU, Mathura, 281 001 U.P., India.
authors.forename: Udayraj P
authors.initials: UP
authors.lastname: Nakade
authors.affiliation: College of Biotechnology, DUVASU, Mathura, 281 001 U.P., India.
authors.forename: Priyambada
authors.initials: P
authors.lastname: Kumari
authors.affiliation: Department of Veterinary Medicine, College of Veterinary Science and Animal Husbandry, DUVASU, Mathura, 281 001 U.P., India.
authors.forename: Mukesh K
authors.initials: MK
authors.lastname: Srivastava
authors.affiliation: Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, DUVASU, Mathura, 281 001 U.P., India.
authors.forename: Abhishek
authors.initials: A
authors.lastname: Sharma
authors.affiliation: Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, DUVASU, Mathura, 281 001 U.P., India.
authors.forename: Soumen
authors.initials: S
authors.lastname: Choudhary
authors.affiliation: Department of Animal Physiology, College of Veterinary Science and Animal Husbandry, DUVASU, Mathura, 281 001 U.P., India.
authors.forename: Dilip
authors.initials: D
authors.lastname: Swain
authors.affiliation: Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, DUVASU, Mathura, 281 001 U.P., India.
authors.forename: Satish K
authors.initials: SK
authors.lastname: Garg
mesh_terms: D000818:Animals; D002020:Buffaloes / Q000276:immunology / Q000469:parasitology*; D002802:Cholinesterases / Q000097:blood* / Q000276:immunology; D009422:Nervous System Diseases / Q000150:complications / Q000662:veterinary*; D014345:Trypanosoma / Q000276:immunology; D014352:Trypanosomiasis / Q000150:complications / Q000201:enzymology / Q000503:physiopathology / Q000662:veterinary*
chemical_list: D002802:Cholinesterases
keywords: Buffaloes; Cholinesterase; Neurological disorders; Trypanosomosis