title: (1)H, (13)C and (15)N backbone resonance assignment for the 40.5 kDa catalytic domain of Ubiquitin Specific Protease 7 (USP7).
abstract: The deubiquitinase Ubiquitin Specific Protease 7 (USP7) is part of the regulatory cascade of proteins that modulates the activity of the tumor suppressor protein p53. Deubiquitination of its target Murine Double Minute 2 (MDM2) leads to increased proteosomal degradation of p53. Consequently, USP7 has emerged as an attractive oncology target because its inhibition stabilizes p53, thereby promoting p53-dependent apoptosis in cancer cells. Here we report the backbone resonance assignment for the 40.5 kDa catalytic domain of USP7.
authors.affiliation: Departments of Structural Biology, Genentech, South San Francisco, CA, 94080, USA. dilellop@gene.com.
authors.forename: Paola
authors.initials: P
authors.lastname: Di Lello
authors.affiliation: Departments of Structural Biology, Genentech, South San Francisco, CA, 94080, USA.
authors.forename: Lionel
authors.initials: L
authors.lastname: Rougé
authors.affiliation: Departments of Structural Biology, Genentech, South San Francisco, CA, 94080, USA.
authors.forename: Borlan
authors.initials: B
authors.lastname: Pan
authors.affiliation: Departments of Structural Biology, Genentech, South San Francisco, CA, 94080, USA. maurer.till@gene.com.
authors.forename: Till
authors.initials: T
authors.lastname: Maurer
mesh_terms: D000595:Amino Acid Sequence; D020134:Catalytic Domain; D006801:Humans; D019906:Nuclear Magnetic Resonance, Biomolecular; D043222:Ubiquitin Thiolesterase / Q000737:chemistry* / Q000378:metabolism; D000076084:Ubiquitin-Specific Peptidase 7
chemical_list: C464569:USP7 protein, human; D043222:Ubiquitin Thiolesterase; D000076084:Ubiquitin-Specific Peptidase 7
keywords: Deubiquitinases; HAUSP; MDM2; NMR assignment; NMR spectroscopy; USP7; p53