title: Towards Identify Selective Antibacterial Peptides Based on Abstracts Meaning.
abstract: We present an Identify Selective Antibacterial Peptides (ISAP) approach based on abstracts meaning. Laboratories and researchers have significantly increased the report of their discoveries related to antibacterial peptides in primary publications. It is important to find antibacterial peptides that have been reported in primary publications because they can produce antibiotics of different generations that attack and destroy the bacteria. Unfortunately, researchers used heterogeneous forms of natural language to describe their discoveries (sometimes without the sequence of the peptides). Thus, we propose that learning the words meaning instead of the antibacterial peptides sequence is possible to identify and predict antibacterial peptides reported in the PubMed engine. The ISAP approach consists of two stages: training and discovering. ISAP founds that the 35% of the abstracts sample had antibacterial peptides and we tested in the updated Antimicrobial Peptide Database 2 (APD2). ISAP predicted that 45% of the abstracts had antibacterial peptides. That is, ISAP found that 810 antibacterial peptides were not classified like that, so they are not reported in APD2. As a result, this new search tool would complement the APD2 with a set of peptides that are candidates to be antibacterial. Finally, 20% of the abstracts were not semantic related to APD2.
authors.affiliation: University of Guadalajara, Guadalajara, JAL, Mexico.
authors.forename: Liliana I
authors.initials: LI
authors.lastname: Barbosa-Santillán
authors.affiliation: Technical and Industrial Teaching Center, Guadalajara, JAL, Mexico.
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Sánchez-Escobar
authors.affiliation: The College of the South Border (ECOSUR), Tapachula, CHIS, Mexico.
authors.forename: M Angeles
authors.initials: MA
authors.lastname: Calixto-Romo
authors.affiliation: University of Guadalajara, Guadalajara, JAL, Mexico.
authors.forename: Luis F
authors.initials: LF
authors.lastname: Barbosa-Santillán
mesh_terms: D000465:Algorithms; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry*; D001424:Bacterial Infections / Q000188:drug therapy; D019295:Computational Biology / Q000379:methods*; D030562:Databases, Protein; D015195:Drug Design; D006801:Humans; D007802:Language; D015233:Models, Statistical; D009323:Natural Language Processing; D010455:Peptides / Q000737:chemistry; D039781:PubMed; D015203:Reproducibility of Results; D012660:Semantics; D012984:Software
chemical_list: D023181:Antimicrobial Cationic Peptides; D010455:Peptides