title: Influence of graft ischemic time and geographic distance between donor and recipient on survival in children after lung transplantation.
abstract: The optimal ischemic time in pediatric lung transplantation (LTx) is unclear, as recent studies have challenged the relevance of 6 hours as an upper limit to acceptable ischemic time.
  
  
  
  Pediatric LTx recipients transplanted between 1987 and 2013 were identified in the United Network for Organ Sharing (UNOS) registry to compare survival according to ischemic time, which was categorized as <4 hours, 4 to 6 hours and >6 hours.
  
  
  
  Nine hundred thirty patients, all <18 years of age and receiving a first-time LTx from a cadaveric donor, were included in our investigation. Compared with <4 hours of ischemic time, univariate analysis showed a significant reduction in mortality hazard with 4 to 6 hours (hazard ratio [HR] = 0.640; 95% confidence interval [CI] 0.502 to 0.816; p < 0.001) but not >6 hours (HR = 0.985; 95% CI 0.755 to 1.284; p = 0.909). A multivariate Cox model confirmed the lowest mortality hazard to be 4 to 6 hours, as compared with <4 hours (HR = 0.533; 95% CI 0.376 to 0.755; p < 0.001). A prolonged ischemic time of >6 hours was associated with increased mortality hazard relative to the 4 to 6 hours (HR = 1.613; 95% CI 1.193 to 2.181; p = 0.002). Supplementary analyses examining geographic distance between donor and recipient identified no association between geographic distance and recipient mortality hazard.
  
  
  
  An ischemic time of 4 to 6 hours was associated with optimal long-term survival in first-time pediatric LTx recipients, whereas a very short ischemic time of <4 hours and a prolonged ischemic time >6 hours were both associated with higher mortality hazard in this population.
authors.affiliation: Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio, USA; Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, Ohio, USA; Department of Surgery, The Ohio State University College of Medicine, Columbus, Ohio, USA; Center for Pediatric Transplant Research, Nationwide Children's Hospital, Columbus, Ohio, USA; Section of Pulmonary Medicine, Nationwide Children's Hospital, Columbus, Ohio, USA. Electronic address: hayes.705@osu.edu.
authors.forename: Don
authors.initials: D
authors.lastname: Hayes
authors.affiliation: Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio, USA; Section of Cardiology, Nationwide Children's Hospital, Columbus, Ohio, USA.
authors.forename: Brian F
authors.initials: BF
authors.lastname: Joy
authors.affiliation: Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio, USA; Center for Perinatal Research, Nationwide Children's Hospital, Columbus, Ohio, USA.
authors.forename: Susan D
authors.initials: SD
authors.lastname: Reynolds
authors.affiliation: Center for Pediatric Transplant Research, Nationwide Children's Hospital, Columbus, Ohio, USA; Department of Anesthesiology and Pain Medicine, Nationwide Children's Hospital, Columbus, Ohio, USA; Department of Anesthesiology, The Ohio State University College of Medicine, Columbus, Ohio, USA.
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Tobias
authors.affiliation: Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio, USA; Center for Pediatric Transplant Research, Nationwide Children's Hospital, Columbus, Ohio, USA; Department of Anesthesiology and Pain Medicine, Nationwide Children's Hospital, Columbus, Ohio, USA.
authors.forename: Dmitry
authors.initials: D
authors.lastname: Tumin
mesh_terms: D002648:Child; D006085:Graft Survival; D006801:Humans; D007511:Ischemia; D016040:Lung Transplantation; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D014019:Tissue Donors
keywords: donor; geographic distance; ischemic time; lung transplantation; recipient; survival