title: The dynamic mechanical properties of cellularised aggregates.
abstract: Cellularised materials are composed of cells interfaced through specialised intercellular junctions that link the cytoskeleton of one cell to that of its neighbours allowing for transmission of forces. Cellularised materials are common in early development and adult tissues where they can be found in the form of cell sheets, cysts, or amorphous aggregates and in pathophysiological conditions such as cancerous tumours. Given the growing realisation that forces can regulate cell physiology and developmental processes, understanding how cellularised materials deform under mechanical stress or dissipate stress appear as key biological questions. In this review, we will discuss the dynamic mechanical properties of cellularised materials devoid of extracellular matrix.
authors.affiliation: London Centre for Nanotechnology, University College London, UK; CoMPLEX PhD Program, University College London, UK.
authors.forename: Nargess
authors.initials: N
authors.lastname: Khalilgharibi
authors.affiliation: London Centre for Nanotechnology, University College London, UK.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Fouchard
authors.affiliation: Department of Mechanical Engineering, Cambridge University, UK.
authors.forename: Pierre
authors.initials: P
authors.lastname: Recho
authors.affiliation: London Centre for Nanotechnology, University College London, UK; Department of Cell and Developmental Biology, University College London, UK; Institute for the Physics of Living Systems, University College London, UK. Electronic address: g.charras@ucl.ac.uk.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Charras
authors.affiliation: Department of Mechanical Engineering, Cambridge University, UK. Electronic address: ajk61@cam.ac.uk.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Kabla
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D002449:Cell Aggregation; D002477:Cells / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D009024:Morphogenesis; D012212:Rheology