title: Low-grade myofibroblastic sarcoma: A population-based study.
abstract: Low-grade myofibroblastic sarcoma (LGMS) is a rare entity that is described as having a predilection for occurring in the head and neck region. Here we analyze its demographics, clinic-pathologic, and survival characteristics.
  
  
  
  Retrospective database analysis.
  
  
  
  A cohort from the Surveillance, Epidemiology, and End Results Program database of cases with LGMS between 2001 and 2012.
  
  
  
  There were 49 cases with a 5-year overall survival of 71.6% and disease- specific survival of 76.3%. The majority of cases were in patients <60 years old, female, and white ethnicity. The most common sites were the extremities in 40.8% of cases followed by the head and neck region with 26.5% of cases. Multivariate analysis showed that only older age was significantly associated with worse survival (P < .05).
  
  
  
  LGMS is uncommon in the United States and occurs most commonly in the extremities followed by the head and neck region, despite an existing characterization of a predilection for the head and neck region. Treatment most commonly involves surgery, but the optimal surgical extent and/or radiotherapy needs to be further investigated.
  
  
  
  2c Laryngoscope, 127:116-121, 2017.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Jason Y K
authors.initials: JY
authors.lastname: Chan
authors.affiliation: Section of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Chicago, Chicago, IL, USA.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Gooi
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Eddy W Y
authors.initials: EW
authors.lastname: Wong
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Siu K
authors.initials: SK
authors.lastname: Ng
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Michael C F
authors.initials: MC
authors.lastname: Tong
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Alexander C
authors.initials: AC
authors.lastname: Vlantis
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005121:Extremities / Q000473:pathology*; D005260:Female; D005354:Fibrosarcoma / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy; D006258:Head and Neck Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009217:Myosarcoma / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D012189:Retrospective Studies; D018426:SEER Program; D015996:Survival Rate; D014481:United States / Q000453:epidemiology
keywords: Low-grade myofibroblastic sarcoma; myofibroblastic sarcoma