title: Relationship of Left Ventricular Diastolic Function to Obesity and Overweight in a Japanese Population With Preserved Left Ventricular Ejection Fraction.
abstract: BACKGROUND
  Obesity has been found to be associated with future development of diastolic heart failure. Other evidence has indicated that the effect of obesity on left ventricular (LV) mass varies among ethnicities. However, there are few data on the relationship between body mass index (BMI) and LV diastolic dysfunction in the Japanese population.
  
  
  RESULTS
  We performed echocardiography in 788 subjects without valvular disease or LV systolic dysfunction. They were divided into 3 groups by BMI: normal weight, overweight, and obese. We used multivariable linear regression analysis to assess the clinical variables associated with diastolic parameters, including BMI. We also assessed the risk of diastolic dysfunction associated with BMI using multivariable logistic models. Overweight and obese subjects had significantly worse LV diastolic function and greater LV mass than normal weight subjects. In the multivariable analysis, BMI was independently associated with diastolic parameters. Furthermore, after adjusting for clinical factors, the increased risks of diastolic dysfunction in overweight subjects (adjusted odds ratio: 2.02, 95% confidence interval 1.21-3.36) and obese subjects (4.85, 3.36-16.27) were greater than those previously observed in Western populations.
  
  
  CONCLUSIONS
  The Japanese population might be more susceptible than Western subjects to the effect of BMI on LV diastolic function. Differences between ethnicities should be taken into consideration in strategies for the prevention of diastolic heart failure. (Circ J 2016; 80: 1951-1956).
authors.affiliation: Department of Cardiovascular Medicine, the University of Tokyo Hospital.
authors.forename: Seitetsu L
authors.initials: SL
authors.lastname: Lee
authors.forename: Masao
authors.initials: M
authors.lastname: Daimon
authors.forename: Marco R
authors.initials: MR
authors.lastname: Di Tullio
authors.forename: Shunichi
authors.initials: S
authors.lastname: Homma
authors.forename: Tomoko
authors.initials: T
authors.lastname: Nakao
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kawata
authors.forename: Koichi
authors.initials: K
authors.lastname: Kimura
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Shinozaki
authors.forename: Megumi
authors.initials: M
authors.lastname: Hirokawa
authors.forename: Tomoko S
authors.initials: TS
authors.lastname: Kato
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Mizuno
authors.forename: Masafumi
authors.initials: M
authors.lastname: Watanabe
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yatomi
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Yamazaki
authors.forename: Issei
authors.initials: I
authors.lastname: Komuro
mesh_terms: D000368:Aged; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D004452:Echocardiography; D005260:Female; D054144:Heart Failure, Diastolic / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D009765:Obesity / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology; D016277:Ventricular Function, Left