title: Peripheral retinal non-perfusion and treatment response in branch retinal vein occlusion.
abstract: OBJECTIVE
  To evaluate the association between the size of peripheral retinal non-perfusion and the number of intravitreal ranibizumab injections in patients with treatment-naive branch retinal vein occlusion (BRVO) and macular edema.
  
  
  METHODS
  A total of 53 patients with treatment-naive BRVO and macular edema were included. Each patient underwent a full ophthalmologic examination including optical coherence tomography (OCT) imaging and ultra wide-field fluorescein angiography (UWFA). Monthly intravitreal ranibizumab injections were applied according to the recommendations of the German Ophthalmological Society. Two independent, masked graders quantified the areas of peripheral retinal non-perfusion.
  
  
  RESULTS
  Intravitreal injections improved best-corrected visual acuity (BCVA) significantly from 22.23±16.33 Early Treatment of Diabetic Retinopathy Study (ETDRS) letters to 36.23±15.19 letters (P<0.001), and mean central subfield thickness significantly reduced from 387±115 µm to 321±115 µm (P=0.01). Mean number of intravitreal ranibizumab injections was 3.61±1.56. The size of retinal non-perfusion correlated significantly with the number of intravitreal ranibizumab injections (R=0.724, P<0.001).
  
  
  CONCLUSIONS
  Peripheral retinal non-perfusion in patients with BRVO associates significantly with intravitreal ranibizumab injections in patients with BRVO and macular edema.
authors.affiliation: Department of Ophthalmology, University Eye Hospital, Medical School of Hannover, Carl-Neuberg-Straße 1, Hannover 30625, Germany.
authors.forename: Kaveh
authors.initials: K
authors.lastname: Abri Aghdam
authors.affiliation: Department of Ophthalmology, Ludwig Maximilians University, Mathildenstr. 8, Munich 80336, Germany.
authors.forename: Lukas
authors.initials: L
authors.lastname: Reznicek
authors.affiliation: Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Sattarkhan-Niayesh Street, Tehran 14456-13131, Iran.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Soltan Sanjari
authors.affiliation: Department of Ophthalmology, University Eye Hospital, Medical School of Hannover, Carl-Neuberg-Straße 1, Hannover 30625, Germany.
authors.forename: Carsten
authors.initials: C
authors.lastname: Framme
authors.affiliation: Department of Ophthalmology, University Eye Hospital, Medical School of Hannover, Carl-Neuberg-Straße 1, Hannover 30625, Germany.
authors.forename: Anna
authors.initials: A
authors.lastname: Bajor
authors.affiliation: Department of Ophthalmology, Ludwig Maximilians University, Mathildenstr. 8, Munich 80336, Germany.
authors.forename: Annemarie
authors.initials: A
authors.lastname: Klingenstein
authors.affiliation: Department of Ophthalmology, Ludwig Maximilians University, Mathildenstr. 8, Munich 80336, Germany.
authors.forename: Marcus
authors.initials: M
authors.lastname: Kernt
authors.affiliation: Department of Ophthalmology, University Eye Hospital, Medical School of Hannover, Carl-Neuberg-Straße 1, Hannover 30625, Germany; Department of Ophthalmology, Ludwig Maximilians University, Mathildenstr. 8, Munich 80336, Germany.
authors.forename: Florian
authors.initials: F
authors.lastname: Seidensticker
keywords: angiography; branch retinal vein occlusion; non-perfusion; retina; wide-field