title: N-Methylniphatyne A, a New 3-Alkylpyridine Alkaloid as an Inhibitor of the Cancer Cells Adapted to Nutrient Starvation, from an Indonesian Marine Sponge of Xestospongia sp.
abstract: In the course of searching for selective growth inhibitors of the cancer cells adapted to nutrient starvation, a new 3-alkylpyridine alkaloid named N-methylniphatyne A (1) was isolated from an Indonesian marine sponge of Xestospongia sp. The chemical structure of 1 was determined on the basis of the spectroscopic analysis and comparison with the synthesized 1 and its analogues. Compound 1 showed the cytotoxic activity against PANC-1 cells under the condition of glucose starvation with IC50 value of 16 µM, whereas no growth-inhibition was observed up to 100 µM under the general culture conditions.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University.
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Arai
authors.forename: Kentaro
authors.initials: K
authors.lastname: Kamiya
authors.forename: Dayoung
authors.initials: D
authors.lastname: Shin
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Matsumoto
authors.forename: Tomoya
authors.initials: T
authors.lastname: Hisa
authors.forename: Andi
authors.initials: A
authors.lastname: Setiawan
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Kotoku
authors.forename: Motomasa
authors.initials: M
authors.lastname: Kobayashi
mesh_terms: D000480:Alkynes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007214:Indonesia; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured; D047131:Xestospongia / Q000737:chemistry*
chemical_list: D000480:Alkynes; D000970:Antineoplastic Agents; C000613633:N-methylniphatyne A; D011725:Pyridines