title: [The correlation study between the changes of intestinal mucosa predominant bacteria and Toll-like receptor 2, Toll-like receptor 4 gene expressions in diarrhea-predominant irritable bowel syndrome patients].
abstract: Based on high throughput sequencing and PCR detection technology, this study has found out that intestinal microbial diversity was impaired and the quantities of two main bacteria flora (Bacteroidetes and Clostridium) were significantly reduced in patients with diarrhea-predominant irritable bowel syndrome (D-IBS). Meanwhile mucosal expression of toll-like receptor (TLR) 2 and TLR4 were significantly enhanced, which was inversely correlated with the reduction of Bacteroidetes and Clostridium. Thus, it suggests that D-IBS may be associated with TLR signal transduction triggered by the intestinal dysbacteriosis.
authors.forename: W T
authors.initials: WT
authors.lastname: Guo
authors.forename: P
authors.initials: P
authors.lastname: Liu
authors.forename: L N
authors.initials: LN
authors.lastname: Dong
authors.affiliation: Department of Gastroenterology, Shanxi Provincial People's Hospital, Taiyuan 030012, China.
authors.forename: J P
authors.initials: JP
authors.lastname: Wang
mesh_terms: D000328:Adult; D001483:Base Sequence; D016022:Case-Control Studies; D003967:Diarrhea / Q000235:genetics* / Q000378:metabolism; D005260:Female; D015870:Gene Expression / Q000235:genetics; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D043183:Irritable Bowel Syndrome / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D017423:Sequence Analysis, RNA / Q000379:methods; D015398:Signal Transduction; D051195:Toll-Like Receptor 2 / Q000235:genetics* / Q000378:metabolism; D051197:Toll-Like Receptor 4 / Q000235:genetics* / Q000378:metabolism
chemical_list: C495342:TLR2 protein, human; C495345:TLR4 protein, human; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4