title: [Statin and cardiovascular diseases after 75 years].
abstract: Statin prescription in persons older than 75 years or with frailty signs raises questions on the role of cholesterol in the genesis of atherosclerosis in this population, on the benefit of this treatment in primary or secondary prevention, and on their side effects in a context of multiple pathology and multiple medications. These questions are approached with the available literature data for this population. In secondary prevention, statin prescription is recommended whatever the age although intensive treatment should be avoided. In primary prevention, in the absence of consensus, their prescription depends on both geriatric and cardiovascular risk assessment.
authors.affiliation: Centre gérontologique départemental, 176, avenue de Montolivet, 13012 Marseille, France; Institut Silvermed, 176, avenue de Montolivet, 13012 Marseille, France; Laboratoire de santé publique, évaluation des systèmes de soins et santé perçue, EA 3279 UFR médecine Aix-Marseille université, 27, boulevard Jean-Moulin, 13385 Marseille Cedex 05, France; Unité de recherche et de soins en médecine interne et maladies infectieuses, hôpital européen, 6, rue Desirée-Clary, 13003 Marseille, France. Electronic address: frederique.retornaz@cgd13.fr.
authors.forename: F
authors.initials: F
authors.lastname: Retornaz
authors.affiliation: Service d'endocrinologie, CHU de Conception, 47, boulevard Baille, 13005 Marseille, France; Faculté de médecine, boulevard Pierre-Dramard, 13005 Marseille, France.
authors.forename: S
authors.initials: S
authors.lastname: Beliard
authors.affiliation: Centre gérontologique départemental, 176, avenue de Montolivet, 13012 Marseille, France.
authors.forename: E
authors.initials: E
authors.lastname: Gremeaux
authors.affiliation: Unité de recherche et de soins en médecine interne et maladies infectieuses, hôpital européen, 6, rue Desirée-Clary, 13003 Marseille, France.
authors.forename: L
authors.initials: L
authors.lastname: Chiche
authors.affiliation: Centre gérontologique départemental, 176, avenue de Montolivet, 13012 Marseille, France.
authors.forename: L
authors.initials: L
authors.lastname: Lagarde
authors.affiliation: Centre gérontologique départemental, 176, avenue de Montolivet, 13012 Marseille, France.
authors.forename: M
authors.initials: M
authors.lastname: Andrianasolo
authors.affiliation: Centre gérontologique départemental, 176, avenue de Montolivet, 13012 Marseille, France; Institut Silvermed, 176, avenue de Montolivet, 13012 Marseille, France.
authors.forename: C
authors.initials: C
authors.lastname: Molines
authors.affiliation: Centre gérontologique départemental, 176, avenue de Montolivet, 13012 Marseille, France; Institut Silvermed, 176, avenue de Montolivet, 13012 Marseille, France; Faculté de médecine, boulevard Pierre-Dramard, 13005 Marseille, France.
authors.forename: C
authors.initials: C
authors.lastname: Oliver
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000097:blood / Q000517:prevention & control*; D002318:Cardiovascular Diseases / Q000097:blood / Q000517:prevention & control*; D002784:Cholesterol / Q000097:blood; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy*; D012307:Risk Factors
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D002784:Cholesterol
keywords: Cardiovascular events; Pathologie cardiovasculaire; Personnes âgées; Primary prevention; Prévention primaire; Prévention secondaire; Secondary prevention; Statin; Statine; Very old persons