title: Encapsulation of curcumin in cyclodextrin-metal organic frameworks: Dissociation of loaded CD-MOFs enhances stability of curcumin.
abstract: Curcumin has been successfully encapsulated in cyclodextrin-metal organic frameworks (CD-MOFs) without altering their crystallinity. The interaction between curcumin and CD-MOFs is strong through hydrogen bond type interaction between the OH group of cyclodextrin of CD-MOFs and the phenolic hydroxyl group of the curcumin. Interestingly, dissolving the curcumin loaded CD-MOFs crystals in water results in formation of a unique complex between curcumin, γCD and potassium cations. In fact, the initial interaction between curcumin and CD-MOF is crucial for the formation of the latter. This new complex formed in alkaline media at pH 11.5 has maximum absorbance at 520nm and emittance at 600nm. Most importantly, the stability of curcumin in this complex was enhanced by at least 3 orders of magnitude compared to free curcumin and curcumin:γ-CD at pH 11.5. These results suggest a promising benign system of CD-MOFs, which can be used to store and stabilize curcumin for food applications.
authors.affiliation: Department of Chemistry, Faculty of Arts and Sciences, American University of Beirut, P.O. Box 11-0236 Riad El Solh, Beirut 1107-2020, Lebanon.
authors.forename: Zeinab
authors.initials: Z
authors.lastname: Moussa
authors.affiliation: Department of Chemistry, Faculty of Arts and Sciences, American University of Beirut, P.O. Box 11-0236 Riad El Solh, Beirut 1107-2020, Lebanon. Electronic address: mohamad.hmadeh@aub.edu.lb.
authors.forename: Mohamad
authors.initials: M
authors.lastname: Hmadeh
authors.affiliation: Department of Nutrition and Food Sciences, Faculty of Agricultural and Food Sciences, American University of Beirut, P.O. Box 11-0236 Riad El Solh, Beirut 1107-2020, Lebanon.
authors.forename: Mohamad G
authors.initials: MG
authors.lastname: Abiad
authors.affiliation: Department of Nutrition and Food Sciences, Faculty of Agricultural and Food Sciences, American University of Beirut, P.O. Box 11-0236 Riad El Solh, Beirut 1107-2020, Lebanon.
authors.forename: Omar H
authors.initials: OH
authors.lastname: Dib
authors.affiliation: Department of Chemistry, Faculty of Arts and Sciences, American University of Beirut, P.O. Box 11-0236 Riad El Solh, Beirut 1107-2020, Lebanon. Electronic address: dp03@aub.edu.lb.
authors.forename: Digambara
authors.initials: D
authors.lastname: Patra
mesh_terms: D003474:Curcumin / Q000737:chemistry* / Q000378:metabolism; D003505:Cyclodextrins / Q000737:chemistry* / Q000378:metabolism; D008670:Metals / Q000737:chemistry* / Q000378:metabolism; D014867:Water / Q000737:chemistry / Q000378:metabolism; D014961:X-Ray Diffraction; D047408:gamma-Cyclodextrins / Q000737:chemistry / Q000378:metabolism
chemical_list: D003505:Cyclodextrins; D008670:Metals; D047408:gamma-Cyclodextrins; D014867:Water; D003474:Curcumin
keywords: CD-MOFs; Curcumin; Encapsulation; Spectroscopy; Stability; γ-Cyclodextrin