title: Clinical response to liposomal doxorubicin and rituximab in HHV-8-associated multicentric Castleman's disease in an HIV-positive patient.
abstract: We report a patient with HIV-associated multicentric Castleman's disease who had recurrent human herpesvirus-8 viremia associated with intermittent febrile exanthema and lymphadenopathy. Although the patient relapsed after single-agent treatment with liposomal doxorubicin, weekly infusions of rituximab led to complete remission even though the reactivation of the Kaposi's sarcoma was unfortunately observed. Rituximab could not only eliminate the accumulation of HHV-8 load but also play a part in the modulation of dysregulated CD20-positive B cells in HIV-associated multicentric Castleman's disease.
authors.affiliation: Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
authors.forename: Morichika
authors.initials: M
authors.lastname: Osa
authors.affiliation: Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, Japan; Department of Microbiology, Saitama Medical University, Saitama, Japan. Electronic address: t_maeda@saitama-med.ac.jp.
authors.forename: Takuya
authors.initials: T
authors.lastname: Maeda
authors.affiliation: Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Misawa
authors.affiliation: Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Imai
authors.affiliation: Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Fujikura
authors.affiliation: Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kawana
mesh_terms: D000368:Aged; D005871:Castleman Disease / Q000188:drug therapy* / Q000821:virology; D004317:Doxorubicin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D015658:HIV Infections / Q000821:virology*; D019288:Herpesvirus 8, Human / Q000187:drug effects*; D006801:Humans; D008297:Male; D011092:Polyethylene Glycols / Q000627:therapeutic use; D000069283:Rituximab / Q000627:therapeutic use*
chemical_list: C506643:liposomal doxorubicin; D011092:Polyethylene Glycols; D000069283:Rituximab; D004317:Doxorubicin
keywords: HHV-8; HIV; Liposomal doxorubicin; Multicentric Castleman's disease; Rituximab