title: Novel Biological Therapies Targeting Heart Failure: Myocardial Rejuvenation.
abstract: Recovery of ventricular function occurs in a subset of patients with advanced heart failure treated with medical and/or mechanical therapy. Finding strategies that induce ventricular recovery through induction of repair, regeneration, or "rejuvenation" is a long-sought goal of research programs. Cell-based strategies, use of recombinant growth and survival factors, and gene delivery are under investigation. In this brief article we highlight a few of the biological approaches in development to treat heart failure.
authors.affiliation: Center for Molecular Medicine, Maine Medical Center Research Institute, Maine Medical Center, 81 Research Drive, Scarborough, ME 04074, USA.
authors.forename: Amanda J
authors.initials: AJ
authors.lastname: Favreau-Lessard
authors.affiliation: Center for Molecular Medicine, Maine Medical Center Research Institute, Maine Medical Center, 81 Research Drive, Scarborough, ME 04074, USA.
authors.forename: Sergey
authors.initials: S
authors.lastname: Ryzhov
authors.affiliation: Center for Molecular Medicine, Maine Medical Center Research Institute, Maine Medical Center, 81 Research Drive, Scarborough, ME 04074, USA. Electronic address: DSawyer@mmc.org.
authors.forename: Douglas B
authors.initials: DB
authors.lastname: Sawyer
mesh_terms: D001691:Biological Therapy; D015316:Genetic Therapy; D006333:Heart Failure / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy*; D006801:Humans; D012060:Rejuvenation / Q000502:physiology*; D015398:Signal Transduction; D033581:Stem Cell Transplantation; D057170:Translational Research, Biomedical
keywords: Cell therapy; Gene therapy; Heart failure; Rejuvenation