title: Association of Lactase Persistence Genotypes with High Intake of Dairy Saturated Fat and High Prevalence of Lactase Non-Persistence among the Mexican Population.
abstract: Lactase (LCT) -13910 C>T and -22018 G>A polymorphisms associated with the lactase non-persistence (LNP)/persistence (LP) phenotypes vary globally. LP has been associated with obesity in Europeans. However, it has not been genetically evaluated in Mexico, a country with admixed population, recent introduction of dairy, and a high prevalence of obesity. Thus, we aimed to determine the distribution of the LCT polymorphisms and their association with the nutritional profile of West Mexico's populations.
  
  
  
  Genotyping of 1,196 individuals (natives and mestizos) was carried out by a Taqman allelic discrimination assay. Descriptive statistics and interpopulation analyzes were performed by SPSS, Arlequin, and Structure software. Demographic, anthropometric, biochemical and dietary data were analyzed in 212 mestizos.
  
  
  
  LNP genotypes mainly prevailed (CC 68.7% and GG 68.2%); both predominated in native Huicholes and Nahuas (>97.7%). Among the mestizos, the LP genotypes were associated with a higher intake of saturated fat (9.9 ± 3.9% vs. 8.5 ± 4.0%, p = 0.018; OR = 2.55, 95% CI 1.29-5.03, p = 0.006) and a daily/more frequent consumption of dairy (88.8 vs. 78.0%; p = 0.049) than LNP genotypes.
  
  
  
  The LNP trait was predominant in Mexicans with a major Amerindian ancestry. A daily consumption of dairy was associated with a higher intake of saturated fat in LP individuals.
authors.affiliation: Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, 'Fray Antonio Alcalde' and Health Sciences Center, University of Guadalajara, Guadalajara, Mexico.
authors.forename: Claudia
authors.initials: C
authors.lastname: Ojeda-Granados
authors.forename: Arturo
authors.initials: A
authors.lastname: Panduro
authors.forename: João Renato
authors.initials: JR
authors.lastname: Rebello Pinho
authors.forename: Omar
authors.initials: O
authors.lastname: Ramos-Lopez
authors.forename: Ketti
authors.initials: K
authors.lastname: Gleyzer
authors.forename: Fernanda de Mello
authors.initials: FM
authors.lastname: Malta
authors.forename: Karina
authors.initials: K
authors.lastname: Gonzalez-Aldaco
authors.forename: Sonia
authors.initials: S
authors.lastname: Roman
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D003611:Dairy Products; D004032:Diet; D059305:Diet, High-Fat; D005006:Ethnicity / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D007198:Indians, North American / Q000235:genetics; D043322:Lactase / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008800:Mexico; D008875:Middle Aged; D054647:Nutrigenomics; D009752:Nutritional Status; D020641:Polymorphism, Single Nucleotide; D044465:White People / Q000235:genetics; D055815:Young Adult
chemical_list: D043322:Lactase