title: Post-translational modifications as key regulators of TNF-induced necroptosis.
abstract: Necroptosis is a novel form of programmed cell death that is independent of caspase activity. Different stimuli can trigger necroptosis. At present, the most informative studies about necroptosis derive from the tumor necrosis factor (TNF)-triggered system. The initiation of TNF-induced necroptosis requires the kinase activity of receptor-interacting protein 1 and 3 (RIP1 and RIP3). Evidence now reveals that the ability of RIP1 and RIP3 to modulate this key cellular event is tightly controlled by post-translational modifications, including ubiquitination, phosphorylation, caspase 8-mediated cleavage and GlcNAcylation. These regulatory events coordinately determine whether a cell will survive or die by apoptosis or necroptosis. In this review, we highlight recent advances in the study of post-translational modifications during TNF-induced necroptosis and discuss how these modifications regulate the complex and delicate control of programmed necrosis.
authors.affiliation: Cancer Research Institute, Xiangya School of Medicine, Central South University, Hunan, China.|Key Laboratory of Chinese Ministry of Education, Central South University, Hunan, China.|Key Laboratory of Carcinogenesis of Chinese Ministry of Public Health, Central South University, Hunan, China.
authors.forename: X
authors.initials: X
authors.lastname: Liu
authors.affiliation: Cancer Research Institute, Xiangya School of Medicine, Central South University, Hunan, China.|Key Laboratory of Chinese Ministry of Education, Central South University, Hunan, China.|Key Laboratory of Carcinogenesis of Chinese Ministry of Public Health, Central South University, Hunan, China.
authors.forename: F
authors.initials: F
authors.lastname: Shi
authors.affiliation: Cancer Research Institute, Xiangya School of Medicine, Central South University, Hunan, China.|Key Laboratory of Chinese Ministry of Education, Central South University, Hunan, China.|Key Laboratory of Carcinogenesis of Chinese Ministry of Public Health, Central South University, Hunan, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.affiliation: Cancer Research Institute, Xiangya School of Medicine, Central South University, Hunan, China.|Key Laboratory of Chinese Ministry of Education, Central South University, Hunan, China.|Key Laboratory of Carcinogenesis of Chinese Ministry of Public Health, Central South University, Hunan, China.|The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Hunan, China.
authors.forename: X
authors.initials: X
authors.lastname: Yu
authors.affiliation: Cancer Research Institute, Xiangya School of Medicine, Central South University, Hunan, China.|Key Laboratory of Chinese Ministry of Education, Central South University, Hunan, China.|Key Laboratory of Carcinogenesis of Chinese Ministry of Public Health, Central South University, Hunan, China.
authors.forename: S
authors.initials: S
authors.lastname: Peng
authors.affiliation: Cancer Research Institute, Xiangya School of Medicine, Central South University, Hunan, China.|Key Laboratory of Chinese Ministry of Education, Central South University, Hunan, China.|Key Laboratory of Carcinogenesis of Chinese Ministry of Public Health, Central South University, Hunan, China.|The Third Xiangya Hospital, Central South University, Hunan, China.
authors.forename: W
authors.initials: W
authors.lastname: Li
authors.affiliation: Cancer Research Institute, Xiangya School of Medicine, Central South University, Hunan, China.|Key Laboratory of Chinese Ministry of Education, Central South University, Hunan, China.|Key Laboratory of Carcinogenesis of Chinese Ministry of Public Health, Central South University, Hunan, China.
authors.forename: X
authors.initials: X
authors.lastname: Luo
authors.affiliation: Cancer Research Institute, Xiangya School of Medicine, Central South University, Hunan, China.|Key Laboratory of Chinese Ministry of Education, Central South University, Hunan, China.|Key Laboratory of Carcinogenesis of Chinese Ministry of Public Health, Central South University, Hunan, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Cao
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D053181:Caspase 8 / Q000378:metabolism; D006801:Humans; D009336:Necrosis; D011499:Protein Processing, Post-Translational / Q000187:drug effects*; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*; D054875:Ubiquitination / Q000187:drug effects
chemical_list: D014409:Tumor Necrosis Factor-alpha; D053181:Caspase 8