title: Effect of Antidepressants on Immunological Reactivity in ASC Mice with Genetically Determined Depression-Like State.
abstract: The effect of chronic treatment with antidepressant drugs fluoxetine (20 mg/kg) and imipramine (25 mg/kg) on the number of antibody-producing cells and the main T cell subpopulations in ASC mice characterized by genetic predisposition to depression-like states was studied at the peak of the SE-induced immune response (5×10(8)). Fluoxetine produced an immunostimulatory effect manifested in an increase in the relative and absolute number of IgM antibody-producing cells in the spleen and index of immunoreactivity (CD4/CD8). Administration of fl uoxetine to parental mouse strains without depression (CBA and AKR) had no effect (CBA) or reduced the immune response. The CD4/CD8 ratio did not increase under these conditions. Imipramine was ineffective in the correction of immune reactions in a depression-like state.
authors.affiliation: Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia. gevorgyanmm@ngs.ru.
authors.forename: M M
authors.initials: MM
authors.lastname: Gevorgyan
authors.affiliation: Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia.
authors.forename: G V
authors.initials: GV
authors.lastname: Idova
authors.affiliation: Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia.
authors.forename: E L
authors.initials: EL
authors.lastname: Al'perina
authors.affiliation: Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia.|Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: M A
authors.initials: MA
authors.lastname: Tikhonova
authors.affiliation: Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Kulikov
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D000938:Antigen-Presenting Cells / Q000187:drug effects / Q000276:immunology; D003863:Depression / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology; D004353:Drug Evaluation, Preclinical; D005473:Fluoxetine / Q000494:pharmacology*; D020022:Genetic Predisposition to Disease; D018655:Lymphocyte Count; D008297:Male; D008808:Mice, Inbred CBA; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects / Q000276:immunology / Q000473:pathology
chemical_list: D000276:Adjuvants, Immunologic; D000928:Antidepressive Agents; D005473:Fluoxetine; D017367:Selective Serotonin Reuptake Inhibitors
keywords: IgM antibody-producing cells; T cell Subpopulations; antidepressants; fluoxetine; imipramine