title: Enantioselective Total Synthesis of the Proposed Structure of Furan-Containing Polyketide.
abstract: Enantioselective total synthesis of the proposed structure of furan-containing polyketide was accomplished. The key features include a chemo- and enantioselective epoxidation of 1,4-cyclohexadiene by Shi asymmetric epoxidation, a regioselective epoxide ring opening, chemo- and diastereoselective dihydroxylation of the conjugated dienone derivative, and vinylation of the lactone accompanied by formation of the furan ring.
authors.affiliation: Tokyo University of Pharmacy and Life Sciences.
authors.forename: Hideki
authors.initials: H
authors.lastname: Abe
authors.forename: Satoko
authors.initials: S
authors.lastname: Itaya
authors.forename: Kei
authors.initials: K
authors.lastname: Sasaki
authors.forename: Toyoharu
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Hisanaka
authors.initials: H
authors.lastname: Ito
mesh_terms: D005663:Furans / Q000737:chemistry*; D015394:Molecular Structure; D061065:Polyketides / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D005663:Furans; D061065:Polyketides; C039281:furan