title: Pioglitazone-induced Pulmonary Injury in a Very Elderly Patient.
abstract: An 85-year-old woman with diabetes mellitus was admitted to our hospital due to progressive dyspnea. Two months previously, pioglitazone had been newly prescribed for diabetes management. Bilateral ground-glass opacities and progressive respiratory deterioration suggested respiratory failure due to a drug-induced lung injury. With discontinuation of pioglitazone and the administration of a corticosteroid, an improvement in her respiratory condition was achieved, although sequelae remained in some areas of the lungs. Results of drug-induced lymphocyte stimulation tests were positive for pioglitazone. Resumption of other drugs did not reinduce the lung injury. Therefore, a diagnosis of pioglitazone-induced lung injury was made. Although pioglitazone-induced lung injury is very rare, clinicians should keep it in mind when pioglitazone is used.
authors.affiliation: Division of General Medicine, Mito Medical Center, University of Tsukuba-Mito Kyodo General Hospital, Japan.
authors.forename: Kohta
authors.initials: K
authors.lastname: Katayama
authors.forename: Ryo
authors.initials: R
authors.lastname: Kumagai
authors.forename: Momoko
authors.initials: M
authors.lastname: Isono
authors.forename: Kazuya
authors.initials: K
authors.lastname: Fujihara
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Yagyu
authors.forename: Gen
authors.initials: G
authors.lastname: Ohara
authors.forename: Katsunori
authors.initials: K
authors.lastname: Kagohashi
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Satoh
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000369:Aged, 80 and over; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D004417:Dyspnea; D005260:Female; D006801:Humans; D055370:Lung Injury / Q000139:chemically induced* / Q000188:drug therapy; D000077205:Pioglitazone; D012131:Respiratory Insufficiency; D045162:Thiazolidinediones / Q000009:adverse effects*
chemical_list: D000305:Adrenal Cortex Hormones; D045162:Thiazolidinediones; D000077205:Pioglitazone