title: Oncological and Surgical Outcome after Oncoplastic Breast Surgery.
abstract: BACKGROUND
  Oncoplastic surgery combines breast-conserving treatment and plastic surgery techniques. The aim of the study was to identify breast and tumor-related characteristics that contribute to the rate of complications and recurrence.
  
  
  METHODS
  This retrospective study included 72 patients with a median follow-up of 32 months. For each patient, a comprehensive set of data was collected, including epidemiology, tumor characteristics, preoperative information, detailed pathology reports, radiotherapy treatment and type of surgical technique. The rate of complications, recurrence and survival were studied.
  
  
  RESULTS
  Complete tumor removal was performed with clear margins in all patients but in 25 of them margins were less than 2 mm. One patient had local recurrence and another developed distant metastases. The study showed that the size of the margin was not predictive of recurrence as long as not positive; the greater the resection volume, the larger the excision margin. The resection size was the only factor influencing complications and no specific tumor-related factor significantly increased the complication rate. Surgical complications did not delay the initiation of chemotherapy and radiotherapy.
  
  
  CONCLUSIONS
  This is the first oncoplastic study where both tumor and breast characteristics were analyzed using the most recent criteria of the literature. Oncoplastic surgery can be considered as oncologically safe. The resection size was the sole significant risk factor for postoperative complications. Complications after oncoplastic breast surgery did not differ neoadjuvant therapy. Long-term event-free survival was excellent (96% at 7 years).
authors.affiliation: a Department of Plastic and Maxillo-facial Surgery, University Hospital , Belgique.
authors.forename: J-L
authors.initials: JL
authors.lastname: Nizet
authors.affiliation: b Department of Abdominal, Breast and Endocrine Surgery and Transplantation , Belgique.
authors.forename: S
authors.initials: S
authors.lastname: Maweja
authors.affiliation: c Department of Senology , Belgique.
authors.forename: F
authors.initials: F
authors.lastname: Lakosi
authors.affiliation: d Department of Anatomo-pathology , Belgique.
authors.forename: E
authors.initials: E
authors.lastname: Lifrange
authors.affiliation: e Department of Biostatistics, SIME ; Belgique .
authors.forename: I
authors.initials: I
authors.lastname: Scagnol
authors.affiliation: f Department of Radiotherapy , Belgique.
authors.forename: L
authors.initials: L
authors.lastname: Seidel
authors.affiliation: f Department of Radiotherapy , Belgique.
authors.forename: A
authors.initials: A
authors.lastname: Albert
authors.affiliation: g Department of Medical Oncology , University Hospital, C.H.U. de Liege, Domaine Universitaire du Sart-Tilman - B. 35 , 4000 Liege, Belgique.
authors.forename: G
authors.initials: G
authors.lastname: Jerusalem
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D016462:Mammaplasty / Q000379:methods*; D015412:Mastectomy, Segmental / Q000009:adverse effects / Q000379:methods*; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D009367:Neoplasm Staging; D061214:Patient Safety; D011183:Postoperative Complications; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D018570:Risk Assessment; D015996:Survival Rate; D016896:Treatment Outcome