title: Enhanced anti-cancer activities of a gold(III) pyrrolidinedithiocarbamato complex incorporated in a biodegradable metal-organic framework.
abstract: An anti-cancer active gold(III) pyrrolidinedithiocarbamato complex [(PDTC)AuIIICl2] (1) has been synthesized and characterized by means of X-ray crystallography. Compared to the pyrrolidinedithiocarbamate ligand itself, this gold(III) complex displays an up to 33-fold higher anti-cancer potency towards a panel of cancer cell lines including the cisplatin-resistant ovarian carcinoma cell line (A2780cis). As demonstrated by a set of Transwell® assay-based cytotoxicity experiments, incorporating this gold(III) complex in a zinc-based biodegradable metal-organic framework (MOF) displays a significant enhancement in anti-cancer activity towards A2780cis than the gold(III) complex alone.
authors.affiliation: Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, 243 Da Xue Road, Shantou, Guangdong 515063, PR China. Electronic address: rwysun@stu.edu.cn.
authors.forename: Raymond Wai-Yin
authors.initials: RW
authors.lastname: Sun
authors.affiliation: Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, 243 Da Xue Road, Shantou, Guangdong 515063, PR China.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, 243 Da Xue Road, Shantou, Guangdong 515063, PR China. Electronic address: dli@stu.edu.cn.
authors.forename: Dan
authors.initials: D
authors.lastname: Li
authors.affiliation: Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, 243 Da Xue Road, Shantou, Guangdong 515063, PR China.
authors.forename: Mian
authors.initials: M
authors.lastname: Li
authors.affiliation: School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong, PR China.
authors.forename: Alice Sze-Tsai
authors.initials: AS
authors.lastname: Wong
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006046:Gold / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D011759:Pyrrolidines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013859:Thiocarbamates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D011759:Pyrrolidines; D013859:Thiocarbamates; D006046:Gold
keywords: Cancer; Carbene; Dithiocarbamate; Gold; Metal-organic framework