title: Local hyperthermia in head and neck cancer: mechanism, application and advance.
abstract: Local hyperthermia (HT), particularly in conjunction with surgery, radiotherapy and chemotherapy was useful for the treatment of human malignant tumors including head and neck cancer. However, at present it suffered from many limitations such as thermal dose control, target treatment regions and discrimination between healthy and cancer cells. Recent developments in nanotechnology have introduced novel and smart therapeutic nanomaterials to local HT of head and neck cancer that basically take advantage of various targeting approaches. The aim of this paper is to give a brief review of the mechanism, methods and clinical applications of local HT in head and neck cancer, mainly focusing on photothermal therapy (PTT) and nanoparticle-based hyperthermia.
authors.affiliation: State Key Laboratory of Oral Diseases West China Hospital of Stomatology, Sichuan University, Chengdu, China.|Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, China.
authors.forename: Shiyu
authors.initials: S
authors.lastname: Gao
authors.affiliation: Department of Stomatology, Zhoushan Hospital, Zhoushan, China.
authors.forename: Min
authors.initials: M
authors.lastname: Zheng
authors.affiliation: Department of Stomatology, Sichuan Medical Science Academy and Sichuan Provincial People's Hospital, Chengdu, China.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Ren
authors.affiliation: State Key Laboratory of Oral Diseases West China Hospital of Stomatology, Sichuan University, Chengdu, China.
authors.forename: Yaling
authors.initials: Y
authors.lastname: Tang
authors.affiliation: State Key Laboratory of Oral Diseases West China Hospital of Stomatology, Sichuan University, Chengdu, China.|Department of Oral and Maxillofacial Surgery West China Hospital of Stomatology, Sichuan University, Chengdu, China.
authors.forename: Xinhua
authors.initials: X
authors.lastname: Liang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use; D003131:Combined Modality Therapy / Q000379:methods*; D005290:Ferric Compounds / Q000737:chemistry; D006046:Gold / Q000737:chemistry; D006258:Head and Neck Neoplasms / Q000628:therapy*; D006360:Heat-Shock Proteins / Q000378:metabolism; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D000860:Hypoxia; D053768:Metal Nanoparticles / Q000737:chemistry; D008872:Microwaves; D050997:Nanomedicine / Q000379:methods*; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D010789:Phototherapy / Q000379:methods; D019265:Spectroscopy, Near-Infrared; D013696:Temperature
chemical_list: D000970:Antineoplastic Agents; D005290:Ferric Compounds; D006360:Heat-Shock Proteins; C000499:ferric oxide; D006046:Gold
keywords: head and neck cancer; heat shock proteins (HSPs); local hyperthermia; nanoparticle; near-infrared (NIR)