title: Development of enteric-coated microspheres of embelin for their beneficial pharmacological potential in ulcerative colitis.
abstract: The aim of the present study is to develop embelin-loaded enteric-coated microspheres and investigate their pharmacological potential in acetic acid induced ulcerative colitis. The optimized formulation of embelin-loaded microspheres has shown significant sustained release of embelin. Further this formulation significantly reduced the ulcer activity score and oxidative stress, and attenuated the inflammatory changes. Thus it may be concluded that embelin-loaded enteric-coated microspheres have shown delayed release capacity than plain embelin and exerts colon ulcer protective effect in rats.
authors.affiliation: a Department of Pharmaceutics , I.S.F. College of Pharmacy , Moga , Punjab , India.
authors.lastname: Nidhi
authors.affiliation: a Department of Pharmaceutics , I.S.F. College of Pharmacy , Moga , Punjab , India.
authors.forename: Ankita
authors.initials: A
authors.lastname: Dadwal
authors.affiliation: a Department of Pharmaceutics , I.S.F. College of Pharmacy , Moga , Punjab , India.
authors.forename: Supandeep Singh
authors.initials: SS
authors.lastname: Hallan
authors.affiliation: b Department of Pharmacology , I.S.F. College of Pharmacy , Moga , Punjab , India.
authors.forename: Saurabh
authors.initials: S
authors.lastname: Sharma
authors.affiliation: a Department of Pharmaceutics , I.S.F. College of Pharmacy , Moga , Punjab , India.
authors.forename: Neeraj
authors.initials: N
authors.lastname: Mishra
mesh_terms: D019342:Acetic Acid / Q000633:toxicity; D000818:Animals; D016227:Benzoquinones / Q000737:chemistry / Q000494:pharmacology; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000494:pharmacology; D003093:Colitis, Ulcerative / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D004195:Disease Models, Animal; D008863:Microspheres; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats
chemical_list: D016227:Benzoquinones; D020099:Coated Materials, Biocompatible; D019342:Acetic Acid; C010945:embelin
keywords: Colon; Eudragit S 100; multiparticulate carrier; pH dependent; time dependent