title: Diagnostic Accuracy of MRI for Assessment of T Category and Circumferential Resection Margin Involvement in Patients With Rectal Cancer: A Meta-Analysis.
abstract: BACKGROUND
  The prognosis of rectal cancer is directly related to the stage of the tumor at diagnosis. Accurate preoperative staging is essential for selecting patients to receive optimal treatment.
  
  
  OBJECTIVE
  The purpose of this study was to evaluate the diagnostic performance of MRI in tumor staging and circumferential resection margin involvement in rectal cancer.
  
  
  METHODS
  A systematic literature search was performed in MEDLINE, EMBASE, PubMed, Cochrane Database of Systematic Reviews, and Web of Science database.
  
  
  METHODS
  Original articles from 2000 to 2016 on the diagnostic performance of MRI in the staging of rectal cancer and/or assessment of mesorectal fascia status were eligible.
  
  
  METHODS
  Pooled diagnostic statistics including sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio were calculated for invasion of muscularis propria, perirectal tissue, and adjacent organs and for circumferential resection margin involvement through bivariate random-effects modeling. Summary receiver operating characteristic curves were fitted, and areas under summary receiver operating characteristic curves were counted to evaluate the diagnostic performance of MRI for each outcome.
  
  
  RESULTS
  Thirty-five studies were eligible for this meta-analysis. Preoperative MRI revealed the highest sensitivity of 0.97 (95% CI, 0.96-0.98) and specificity of 0.97 (95% CI, 0.96-0.98) for muscularis propria invasion and adjacent organ invasion. Areas under summary receiver operating characteristic curves indicated good diagnostic accuracy for each outcome, with the highest of 0.9515 for the assessment of adjacent organ invasion. Significant heterogeneity existed among studies. There was no notable publication bias for each outcome.
  
  
  CONCLUSIONS
  This meta-analysis revealed relatively high diagnostic accuracy for preoperative MRI, although significant heterogeneity existed. Therefore, exploration should be focused on standardized interpretation criteria and optimal MRI protocols for future studies.
  
  
  CONCLUSIONS
  MRI showed relatively high diagnostic accuracy for preoperative T staging and circumferential resection margin assessment and should be reliable for clinical decision making.
authors.affiliation: 1 Department of Radiology, Sichuan Cancer Hospital, Chengdu, Sichuan, China 2 Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Ge
authors.initials: G
authors.lastname: Zhang
authors.forename: Yu-Zhe
authors.initials: YZ
authors.lastname: Cai
authors.forename: Guo-Hui
authors.initials: GH
authors.lastname: Xu
mesh_terms: D006801:Humans; D008279:Magnetic Resonance Imaging; D000072662:Margins of Excision; D015233:Models, Statistical; D009367:Neoplasm Staging; D011300:Preoperative Care; D012004:Rectal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D012007:Rectum / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery