title: Transient Elastography for Spleen Stiffness Measurement in Patients With Cirrhosis: Role in Degree of Thrombocytopenia.
abstract: OBJECTIVE
  The purpose of our study was to evaluate the relationship between spleen stiffness measured by transient elastography and the degree of thrombocytopenia in patients with liver cirrhosis.
  
  
  METHODS
  A total of 67 patients with liver cirrhosis were prospectively enrolled in the study. All patients underwent single-day hematologic and biochemical tests, sonography, and transient elastography of the liver and spleen. Thrombocytopenia was categorized as mild (platelet count, 75,000-150,000/μL), moderate (50,000-75,000/μL), and severe (<50,000/μL).
  
  
  RESULTS
  The degree of thrombocytopenia was significantly correlated with spleen stiffness (P = .001) and spleen size (P = .002) but not with liver stiffness (P = .086). In patients without splenomegaly, spleen stiffness values were significantly higher in patients with thrombocytopenia than in those without thrombocytopenia (P = .035). In patients with splenomegaly, spleen stiffness values were significantly higher in patients with moderate to severe thrombocytopenia than in those with a normal platelet count or mild thrombocytopenia (P = .007). Compared to liver stiffness, spleen stiffness showed a better and statistically significant correlation with platelet count and spleen size in patients with cirrhosis.
  
  
  CONCLUSIONS
  The degree of thrombocytopenia was directly correlated with spleen stiffness, irrespective of the presence of splenomegaly. The clinical phenomenon of unexpected thrombocytopenia may be explained by a subtle or irreversible change in spleen stiffness.
authors.affiliation: Liver Research Unit, Chang Gung Memorial Hospital, Keelung, Taiwan, Chang Gung University, College of Medicine, Taoyuan, Taiwan.
authors.forename: Cheng-Hung
authors.initials: CH
authors.lastname: Chien
authors.affiliation: Department of Radiology, Hsinchu Mackay Memorial Hospital, Taiwan, Mackay Junior College of Medicine, Nursing, and Management, Taiwan.
authors.forename: Yi-Lan
authors.initials: YL
authors.lastname: Lin
authors.affiliation: Liver Research Unit, Chang Gung Memorial Hospital, Keelung, Taiwan, Chang Gung University, College of Medicine, Taoyuan, Taiwan.
authors.forename: Rong-Nan
authors.initials: RN
authors.lastname: Chien
authors.affiliation: Liver Research Unit, Chang Gung Memorial Hospital, Keelung, Taiwan, Chang Gung University, College of Medicine, Taoyuan, Taiwan.
authors.forename: Ching-Chih
authors.initials: CC
authors.lastname: Hu
authors.affiliation: Liver Research Unit, Chang Gung Memorial Hospital, Keelung, Taiwan.
authors.forename: Cho-Li
authors.initials: CL
authors.lastname: Yen
authors.affiliation: Department of Gastroenterology, Chang Gung Memorial Hospital, Keelung, Taiwan.
authors.forename: Tsung-Shih
authors.initials: TS
authors.lastname: Lee
authors.affiliation: Liver Research Unit, Chang Gung Memorial Hospital, Keelung, Taiwan, Chang Gung University, College of Medicine, Taoyuan, Taiwan.
authors.forename: Po-Jen
authors.initials: PJ
authors.lastname: Hsieh
authors.affiliation: Liver Research Unit, Chang Gung Memorial Hospital, Keelung, Taiwan, Chang Gung University, College of Medicine, Taoyuan, Taiwan.
authors.forename: Chih-Lang
authors.initials: CL
authors.lastname: Lin
mesh_terms: D054459:Elasticity Imaging Techniques; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012372:ROC Curve; D013154:Spleen / Q000000981:diagnostic imaging* / Q000473:pathology*; D013921:Thrombocytopenia / Q000150:complications* / Q000473:pathology
keywords: gastrointestinal ultrasound; liver cirrhosis; liver stiffness; spleen stiffness; splenomegaly; thrombocytopenia; transient elastography