title: Persistent Infection of Drug-resistant Influenza A Virus during Chemotherapy for Malignant Lymphoma.
abstract: We herein report the case of an 80-year-old man with malignant lymphoma who became persistently infected with influenza A virus. Although he was repeatedly treated with NA inhibitors, such as oseltamivir or peramivir, nasal cavity swab tests for influenza A antigen continued to be positive for more than 2 months. Virological analyses revealed that he was infected with the NA inhibitor-resistant A (H3N2) virus possessing an R292K substitution in the NA protein. These findings suggest that a drug-resistant influenza virus strain might selectively survive antiviral therapy in elderly patients with refractory malignant lymphoma undergoing multiple chemotherapies.
authors.affiliation: Division of Hematology, NHO Matsumoto Medical Center, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Kawakami
authors.forename: Yukio
authors.initials: Y
authors.lastname: Hirabayashi
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Kawakami
authors.forename: Rei
authors.initials: R
authors.lastname: Isobe
authors.forename: Naoto
authors.initials: N
authors.lastname: Kaneko
authors.forename: Yuto
authors.initials: Y
authors.lastname: Mimura
authors.forename: Toshiro
authors.initials: T
authors.lastname: Ito
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Furuta
authors.forename: Mami
authors.initials: M
authors.lastname: Shimazaki
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Nakazawa
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Kitano
mesh_terms: D000146:Acids, Carbocyclic; D000369:Aged, 80 and over; D000998:Antiviral Agents / Q000627:therapeutic use*; D003517:Cyclopentanes / Q000627:therapeutic use; D024882:Drug Resistance, Viral; D006146:Guanidines / Q000627:therapeutic use; D006801:Humans; D053122:Influenza A Virus, H3N2 Subtype; D007251:Influenza, Human / Q000821:virology*; D008223:Lymphoma / Q000188:drug therapy*; D008297:Male; D009154:Mutation; D009439:Neuraminidase / Q000037:antagonists & inhibitors* / Q000235:genetics; D053139:Oseltamivir / Q000627:therapeutic use
chemical_list: D000146:Acids, Carbocyclic; D000998:Antiviral Agents; D003517:Cyclopentanes; D006146:Guanidines; D053139:Oseltamivir; D009439:Neuraminidase; C414210:peramivir