title: The Effect of Preoperative Type 2 Diabetes and Physical Fitness on Mental Health and Health-Related Quality of Life after Roux-en-Y Gastric Bypass.
abstract: Objective. To investigate the predictive value of type 2 diabetes and lack of physical activity for mental health and health-related quality of life after Roux-en-Y gastric bypass. Method. Forty severely obese patients undergoing Roux-en-Y gastric bypass were included in the GASMITO study. Information about physiological and psychological factors was prospectively assessed at four time points, two times prior to surgery and two times after surgery. Measures included oral and intravenous glucose tolerance tests, VO2max test, Symptoms Checklist (SCL-90), Short Form Health Survey 36 (SF-36), Body Image Questionnaire, and a questionnaire assessing sociodemographic factors and medical status. Results. Mean % excess weight loss was 65% (±12) at 18-month follow-up and 50% of the participants with diabetes experienced total remission. Also, significant improvements were observed with regard to physical fitness, mental distress, health-related quality of life, and weight-related body image (p < 0.05). The interaction between follow-up time and type 2 diabetes at baseline significantly predicted six of the thirteen psychological subscales (p < 0.05) and, across the follow-ups, physical fitness level made modest contributions to variations in mental symptoms and HRQOL but not weight-related body image. Conclusion. The results suggest that baseline difference in mental symptoms and physical HRQOL between diabetic and nondiabetic patients declines across follow-ups and resolves around the time of surgery.
authors.affiliation: Section of Environmental Health, Department of Public Health, University of Copenhagen, 1353 Copenhagen K, Denmark; Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark.
authors.forename: Cathrine L
authors.initials: CL
authors.lastname: Wimmelmann
authors.affiliation: Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark; Xlab, Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark.
authors.forename: Michael T
authors.initials: MT
authors.lastname: Lund
authors.affiliation: Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark; Xlab, Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark.
authors.forename: Merethe
authors.initials: M
authors.lastname: Hansen
authors.affiliation: Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark; Xlab, Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark.
authors.forename: Flemming
authors.initials: F
authors.lastname: Dela
authors.affiliation: Section of Environmental Health, Department of Public Health, University of Copenhagen, 1353 Copenhagen K, Denmark; Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark.
authors.forename: Erik L
authors.initials: EL
authors.lastname: Mortensen
mesh_terms: D000328:Adult; D000713:Anastomosis, Roux-en-Y; D001828:Body Image; D003866:Depressive Disorder / Q000150:complications* / Q000523:psychology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D015444:Exercise; D005260:Female; D006801:Humans; D008297:Male; D009767:Obesity, Morbid / Q000150:complications* / Q000523:psychology / Q000601:surgery; D011446:Prospective Studies; D011788:Quality of Life; D011795:Surveys and Questionnaires