title: Effect of colchicine in prevention of pericardial effusion and atrial fibrillation: a meta-analysis.
abstract: Randomized, controlled trials (RCTs) have assessed the effect of colchicine therapy in prevention of pericardial effusion (PE) and atrial fibrillation (AF). However, the effects are still inconclusive. PubMed, Cochrane Library, Google Scholar, and EMBASE database were searched. Primary outcome was the risk of PE and AF. Ten RCTs with 1981 patients and a mean follow-up of 12.6 months were included. Colchicine therapy was not associated with a significantly lower risk of post-operative PE (RR, 0.89; 95 % CI 0.70-1.13; p = 0.33, I (2) = 72.8 %) and AF (RR, 0.77; 95 % CI 0.52-1.13; p = 0.18, I (2) = 47.3 %). However, rates of pericarditis recurrence, symptoms persistence, and pericarditis-related hospitalization were significantly decreased with colchicine treatment. In addition, cardiac tamponade occurrence was similar between groups, and adverse events were significantly higher in the colchicine group. Colchicine may not significantly decrease the post-operative risk of PE and AF. However, only limited studies about patients undergoing cardiac surgery provide data about PE and AF.
authors.affiliation: Department of Emergency Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
authors.forename: Ming-Xuan
authors.initials: MX
authors.lastname: Wang
authors.affiliation: Department of Neurology, Wuhan Medical & Healthcare Center for Women and Children, Wuhan Children's Hospital, Wuhan, Hubei, China.
authors.forename: Xiao-Long
authors.initials: XL
authors.lastname: Deng
authors.affiliation: Department of Rheumatology, Beijing Hospital, No. 1, Dahua Road, East District, Beijing, China.
authors.forename: Bing-Yao
authors.initials: BY
authors.lastname: Mu
authors.affiliation: Department of Rheumatology, Beijing Hospital, No. 1, Dahua Road, East District, Beijing, China.
authors.forename: Yong-Jing
authors.initials: YJ
authors.lastname: Cheng
authors.affiliation: Department of Rheumatology, Beijing Hospital, No. 1, Dahua Road, East District, Beijing, China.
authors.forename: Ying-Juan
authors.initials: YJ
authors.lastname: Chen
authors.affiliation: Department of Rheumatology, Beijing Hospital, No. 1, Dahua Road, East District, Beijing, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Rheumatology, Beijing Hospital, No. 1, Dahua Road, East District, Beijing, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Rheumatology, Beijing Hospital, No. 1, Dahua Road, East District, Beijing, China.
authors.forename: Rong-Wei
authors.initials: RW
authors.lastname: Zhou
authors.affiliation: Department of Rheumatology, Beijing Hospital, No. 1, Dahua Road, East District, Beijing, China. huangcb1208@sina.com.
authors.forename: Ci-Bo
authors.initials: CB
authors.lastname: Huang
mesh_terms: D001281:Atrial Fibrillation / Q000188:drug therapy / Q000517:prevention & control*; D006348:Cardiac Surgical Procedures / Q000009:adverse effects / Q000706:statistics & numerical data; D016009:Chi-Square Distribution; D003078:Colchicine / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D010490:Pericardial Effusion / Q000188:drug therapy / Q000517:prevention & control*; D010493:Pericarditis / Q000188:drug therapy / Q000517:prevention & control; D012008:Recurrence
chemical_list: D003078:Colchicine
keywords: Atrial fibrillation; Cardiac tamponade; Colchicine; Pericardial effusion; Pericarditis recurrence