title: Preventing the BDNF and NGF loss involved in the effects of cornel iridoid glycoside on attenuation of experimental autoimmune encephalomyelitis in mice.
abstract: The present study was designed to investigate the beneficial effects of cornel iridoid glycoside (CIG), a main component extract from Cornus officinalis, on neurotrophin expression in mouse experimental autoimmune encephalomyelitis (EAE), a classical model of multiple sclerosis (MS). After EAE initiation, CIG was intragastrically administered daily for 32 days and reduced disease severity. Histopathological staining and western blotting both showed that CIG could prevent brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) loss in the spinal cord of EAE mice. In conclusion, our findings indicated that CIG treatment suppressed disease severity of EAE partially through blocking downregulation of neurotrophic factor expression such as BDNF and NGF, suggesting that CIG may have beneficial effects for the treatment of demyelinating diseases such as MS.
authors.affiliation: a Xuan Wu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education , Beijing Geriatric Medical Research Center, Beijing Institute for Brain Disorders , Beijing , P.R. China.|b Institute of Clinical Pharmacology , Guangzhou University of Chinese Medicine , Guangzhou , P.R. China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Qu
authors.affiliation: a Xuan Wu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education , Beijing Geriatric Medical Research Center, Beijing Institute for Brain Disorders , Beijing , P.R. China.|b Institute of Clinical Pharmacology , Guangzhou University of Chinese Medicine , Guangzhou , P.R. China.
authors.forename: Na
authors.initials: N
authors.lastname: Zheng
authors.affiliation: a Xuan Wu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education , Beijing Geriatric Medical Research Center, Beijing Institute for Brain Disorders , Beijing , P.R. China.|b Institute of Clinical Pharmacology , Guangzhou University of Chinese Medicine , Guangzhou , P.R. China.
authors.forename: Yifan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: a Xuan Wu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education , Beijing Geriatric Medical Research Center, Beijing Institute for Brain Disorders , Beijing , P.R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: a Xuan Wu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education , Beijing Geriatric Medical Research Center, Beijing Institute for Brain Disorders , Beijing , P.R. China.
authors.forename: Jianghong
authors.initials: J
authors.lastname: Liu
authors.affiliation: b Institute of Clinical Pharmacology , Guangzhou University of Chinese Medicine , Guangzhou , P.R. China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.affiliation: a Xuan Wu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education , Beijing Geriatric Medical Research Center, Beijing Institute for Brain Disorders , Beijing , P.R. China.
authors.forename: Linlin
authors.initials: L
authors.lastname: Yin
mesh_terms: D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000150:complications / Q000188:drug therapy*; D005260:Female; D005620:Freund's Adjuvant / Q000633:toxicity; D005786:Gene Expression Regulation / Q000187:drug effects; D057888:Iridoid Glucosides / Q000008:administration & dosage*; D051379:Mice; D008810:Mice, Inbred C57BL; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D009103:Multiple Sclerosis / Q000150:complications / Q000188:drug therapy*; D063308:Myelin-Oligodendrocyte Glycoprotein / Q000633:toxicity; D020932:Nerve Growth Factor / Q000378:metabolism*; D009422:Nervous System Diseases / Q000209:etiology / Q000517:prevention & control; D010446:Peptide Fragments / Q000633:toxicity; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D013116:Spinal Cord / Q000378:metabolism*; D018709:Statistics, Nonparametric; D013997:Time Factors
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D057888:Iridoid Glucosides; D008869:Microtubule-Associated Proteins; C079240:Mtap2 protein, mouse; D063308:Myelin-Oligodendrocyte Glycoprotein; D010446:Peptide Fragments; C445081:myelin oligodendrocyte glycoprotein (35-55); D005620:Freund's Adjuvant; D020932:Nerve Growth Factor; D010751:Phosphopyruvate Hydratase
keywords: Cornel iridoid glycoside; Experimental autoimmune encephalomyelitis; Multiple sclerosis; Neurotrophic factors