title: Lymphocytopenia is associated with anti-Beta-2 glycoprotein-1 in patients with 220 systemic lupus erythematosus.
abstract: BACKGROUND
  Anti B2-Glicoprotein 1 (B2-GPI) is an antiphospholipid antibody that may be present in primary or secondary antiphospholipid syndrome (APS). Systemic Lupus erythematosus (SLE) is the main disease associated with secondary APS.
  
  
  OBJECTIVE
  To study the prevalence of anti B2-GPI in SLE patients.
  
  
  METHODS
  Anti B2-GPI (IgM/IgG) was studied by ELISA in 88 patients with SLE of both genders; 18.6% of which with secondary APS. Charts were reviewed for clinical and serological profile.
  
  
  RESULTS
  Anti B2-GPI was present in 18.6% of the whole sample and in 29.4% of those with secondary APS. At univariated analysis, the presence of anti B2-GPI was more common in patients with serositis (p=0.04), lymphocytopenia (p=0.003) and anti cardiolipin (aCl) IgM antibodies (p=0.04). In a logistic regression study, only the associations with lymphocytopenia (OR=8.2; 95%CI=2.1-39.3) and aCl IgM (p=0.04; OR=3.4; 95%CI=1.05-11.1) remained significant.
  
  
  CONCLUSIONS
  There is a 18.6% prevalence of positive anti B2-GPI in SLE population that is associated with the presence of aCl IgM and lymphocytopenia.
authors.forename: T
authors.initials: T
authors.lastname: Skare
authors.forename: E A
authors.initials: EA
authors.lastname: Borba
authors.forename: S R
authors.initials: SR
authors.lastname: Utiyama
authors.forename: R
authors.initials: R
authors.lastname: Nisihara
mesh_terms: D000293:Adolescent; D000328:Adult; D016736:Antiphospholipid Syndrome / Q000097:blood / Q000150:complications; D001323:Autoantibodies / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000150:complications*; D008231:Lymphopenia / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D055815:Young Adult; D053482:beta 2-Glycoprotein I / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D053482:beta 2-Glycoprotein I