title: Endoplasmic reticulum stress related molecular mechanisms in nonalcoholic steatohepatitis.
abstract: Nonalcoholic steatohepatitis (NASH) is considered to be a common health problem since the incidence of nonalcoholic fatty liver disease (NAFLD) has increased in recent years. Disturbed hepatic cholesterol homeostasis and free cholesterol accumulation in liver results in increased oxidative stress leading to the endoplasmic reticulum (ER) stress. Activated ER stress maintains protein homeostasis however, delayed or inadequate ER stress responses may induce fat accumulation, insulin resistance, inflammation, apoptosis, and autophagy, all of which increase with age and play crucial roles in the pathogenesis of NASH. In aging research, there is a growing interest for the role of ER stress in the progression of NASH since aging seems to favor NAFLD according to its pathogenesis. On the other hand, specific microRNAs (miRNAs) expression profiles are strongly related with ER stress as well as NASH progresses. This review highlights molecular mechanisms related to ER stress in the pathogenesis of NASH and miRNAs for the progression and treatment of the disease.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Genetic and Metabolic Diseases Research and Investigation Center (GEMHAM), Marmara University, 34854, Maltepe, Istanbul, Turkey.
authors.forename: Perinur
authors.initials: P
authors.lastname: Bozaykut
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Genetic and Metabolic Diseases Research and Investigation Center (GEMHAM), Marmara University, 34854, Maltepe, Istanbul, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Sahin
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Genetic and Metabolic Diseases Research and Investigation Center (GEMHAM), Marmara University, 34854, Maltepe, Istanbul, Turkey.
authors.forename: Betul
authors.initials: B
authors.lastname: Karademir
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Genetic and Metabolic Diseases Research and Investigation Center (GEMHAM), Marmara University, 34854, Maltepe, Istanbul, Turkey. Electronic address: nkozer@marmara.edu.tr.
authors.forename: Nesrin Kartal
authors.initials: NK
authors.lastname: Ozer
mesh_terms: D000818:Animals; D017209:Apoptosis; D001343:Autophagy; D002784:Cholesterol / Q000378:metabolism*; D059865:Endoplasmic Reticulum Stress; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D007333:Insulin Resistance; D065626:Non-alcoholic Fatty Liver Disease / Q000378:metabolism* / Q000473:pathology / Q000628:therapy
chemical_list: D002784:Cholesterol
keywords: Endoplasmic reticulum stress; Hypercholesterolemia; MicroRNAs; Nonalcoholic steatohepatitis; Unfolded protein response