title: A case of gabapentin-induced rhabdomyolysis requiring renal replacement therapy.
abstract: Gabapentin is commonly used for controlling convulsions, restless pain syndrome, and pain in diabetic neuropathy. Common side effects include dizziness, somnolence, ataxia, peripheral edema, and confusion; gabapentin-induced rhabdomyolysis is rarely reported. To date, the reported cases of gabapentin-induced rhabdomyolysis have been associated with patients with multiple underlying diseases and assuming multiple medicines for various reasons. In this report, we describe a case of gabapentin-induced rhabdomyolysis in a 32-year-old woman with no medical history. We also review related literature and discuss the possible mechanism and the association with other factors. This case shows that gabapentin can induce rhabdomyolysis in healthy patients and that clinicians must consider the possible association between gabapentin and rhabdomyolysis.
authors.affiliation: Department of Internal Medicine, St. Vincent Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Min Seok
authors.initials: MS
authors.lastname: Choi
authors.affiliation: Department of Internal Medicine, St. Vincent Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Howook
authors.initials: H
authors.lastname: Jeon
authors.affiliation: Department of Internal Medicine, St. Vincent Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Hyo Suk
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, St. Vincent Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Bo Hyun
authors.initials: BH
authors.lastname: Jang
authors.affiliation: Department of Internal Medicine, St. Vincent Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Yoon Hee
authors.initials: YH
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, St. Vincent Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Hoon Suk
authors.initials: HS
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, St. Vincent Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: HyungWook
authors.initials: H
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, St. Vincent Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Dong Chan
authors.initials: DC
authors.lastname: Jin
mesh_terms: D000328:Adult; D000588:Amines / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D003509:Cyclohexanecarboxylic Acids / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D000077206:Gabapentin; D006801:Humans; D006435:Renal Dialysis / Q000009:adverse effects*; D017582:Renal Replacement Therapy / Q000009:adverse effects* / Q000379:methods; D012206:Rhabdomyolysis / Q000139:chemically induced*; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000588:Amines; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin
keywords: Gabapentin; renal replacement therapy; rhabdomyolysis