title: New Bitter Diterpenes, Rabdosianone I and II, Isolated from Isodon japonicus Hara.
abstract: The new bitter diterpenes, rabdosianone I (C20H24O5) and II (C22H28O6), were isolated from Isodon japonicus (Japanese name, enmeiso), and their structures were elucidated by spectroscopic methods. Electrophysiological experiments were performed to compare rabdosianone I with quinine. The taste responses of chorda tympani nerves to rabdosianone I were smaller than those to quinine in Wistar rats.
authors.affiliation: a Department of Food Science and Nutrition, Doshisha Women's College.
authors.forename: Y
authors.initials: Y
authors.lastname: Yamada
authors.affiliation: b Department of Behavioral Physiology, Faculty of Human Sciences, Osaka University.
authors.forename: N
authors.initials: N
authors.lastname: Sako
authors.affiliation: a Department of Food Science and Nutrition, Doshisha Women's College.
authors.forename: E
authors.initials: E
authors.lastname: Ando
authors.affiliation: a Department of Food Science and Nutrition, Doshisha Women's College.
authors.forename: M
authors.initials: M
authors.lastname: Yamada
authors.affiliation: c Department of Food and Nutrition, Osaka City University.
authors.forename: H
authors.initials: H
authors.lastname: Kikuzaki
authors.affiliation: b Department of Behavioral Physiology, Faculty of Human Sciences, Osaka University.
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
keywords: Isodon japonicus; bitterness; electrophysiology; rabdosianone I; rabdosianone II