title: Protective effects of Emblica officinalis (Amla) on metal-induced lipid peroxidation in human erythrocytes.
abstract: The protective potential of Emblica officinalis (amla) was investigated on metal-induced lipid per oxidation in human erythrocytes. Increases in the levels of MDA and catalase activity were assessed as lipid per oxidation. In addition, glutathione peroxidase (GPX), glutathione (GSH), and ascorbic acid levels were assessed as antioxidant indices. Preliminary investigation of the extract exhibited a significant reduction in lipid per oxidation and an increase in antioxidant abilities, such as a decrease in MDA, GPx and GSH (P<0.05). A significant reduction in erythrocyte hemolysis induced by hydrogen peroxide was observed using amla extract (P<0.05). These findings show that amla extract has significant protective potential against lipid per oxidation.
authors.affiliation: Department of Biotechnology, Mohamed Sathak College of Arts and Science, Chennai, India.
authors.forename: Vijay Kumar
authors.initials: VK
authors.lastname: Krishnamoorthy
authors.affiliation: Department of Applied Microbiology and Biotechnology, School of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk, Korea.
authors.forename: Irfan Ahmad
authors.initials: IA
authors.lastname: Rather
mesh_terms: D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D015415:Biomarkers / Q000378:metabolism; D019610:Cytoprotection; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D006861:Hydrogen Peroxide / Q000633:toxicity; D015227:Lipid Peroxidation / Q000187:drug effects*; D008670:Metals / Q000633:toxicity*; D018384:Oxidative Stress / Q000187:drug effects*; D029842:Phyllanthus emblica / Q000737:chemistry; D008517:Phytotherapy; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D008670:Metals; D010936:Plant Extracts; D006861:Hydrogen Peroxide