title: [Not Available].
abstract: OBJECTIVE
  The objective of our work is to search if there is a relation between azathioprine's metabolites (6-thioguanines nucleotides and 6-methyl mercaptopurines) and clinical efficacy and adverse effects of azathioprine in inflammatory bowel disease population.
  
  
  METHODS
  We included patients with Crohn's disease or ulcerative colitis (UC) treated by azathioprine for a duration more than 1year. Each patient had a dosage of azathioprine metabolites.
  
  
  RESULTS
  We included 43 Crohn's disease patients and 7 UC. Azathioprine was indicated for steroid dependancy in 23 cases, to prevent post-operative recurrence in 10 cases, to maintain clinical remission obtained by medical treatment in 17 patients. A clinical response to azathioprine (obtention of remission, absence of recurrence during the follow up) was observed in 34 patients.
  
  
  CONCLUSIONS
  Our work confirms the relation between the doses of azathioprine metabolites and the myelotoxicity due to this molecule.
authors.affiliation: Service de Pharmacologie clinique, Centre national de Pharmacovigilance, Tunis, Tunisie. Electronic address: melaouhiasalma@yahoo.fr.
authors.forename: Salma
authors.initials: S
authors.lastname: Melaouhia
authors.affiliation: Service de Gastroentérologie A, Hôpital la Rabta, Tunis, Tunisie.
authors.forename: Monia
authors.initials: M
authors.lastname: Fékih
authors.affiliation: Service de Pharmacologie clinique, Centre national de Pharmacovigilance, Tunis, Tunisie.
authors.forename: Henda
authors.initials: H
authors.lastname: Ferchichi
authors.affiliation: Service de Gastroentérologie A, Hôpital la Rabta, Tunis, Tunisie.
authors.forename: Houda
authors.initials: H
authors.lastname: Bouissorra
authors.affiliation: Service de Gastroentérologie A, Hôpital la Rabta, Tunis, Tunisie.
authors.forename: Nadia Ben
authors.initials: NB
authors.lastname: Mustapha
authors.affiliation: Service de Gastroentérologie A, Hôpital la Rabta, Tunis, Tunisie.
authors.forename: Jalel
authors.initials: J
authors.lastname: Boubaker
authors.affiliation: Service de Gastroentérologie A, Hôpital la Rabta, Tunis, Tunisie.
authors.forename: Azza
authors.initials: A
authors.lastname: Filali
authors.affiliation: Service de Pharmacologie clinique, Centre national de Pharmacovigilance, Tunis, Tunisie.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Lakhal
authors.affiliation: Service de Pharmacologie clinique, Centre national de Pharmacovigilance, Tunis, Tunisie.
authors.forename: Anis
authors.initials: A
authors.lastname: Klouz
keywords: 6- methyl mercaptopurine; 6-méthyl mercaptopurine; 6-thioguanine nucleotide; 6-thioguaninenucléotide; azathioprine; inflammatory bowel disease; maladie inflammatoire chronique de l’intestin