title: Characterizing amide proton transfer imaging in haemorrhage brain lesions using 3T MRI.
abstract: OBJECTIVE
  The aim of this study was to characterize amide proton transfer (APT)-weighted signals in acute and subacute haemorrhage brain lesions of various underlying aetiologies.
  
  
  METHODS
  Twenty-three patients with symptomatic haemorrhage brain lesions including tumorous (n = 16) and non-tumorous lesions (n = 7) were evaluated. APT imaging was performed and analyzed with magnetization transfer ratio asymmetry (MTRasym). Regions of interest were defined as the enhancing portion (when present), acute or subacute haemorrhage, and normal-appearing white matter based on anatomical MRI. MTRasymvalues were compared among groups and components using a linear mixed model.
  
  
  RESULTS
  MTRasymvalues were 3.68 % in acute haemorrhage, 1.6 % in subacute haemorrhage, 2.65 % in the enhancing portion, and 0.38 % in normal white matter. According to the linear mixed model, the distribution of MTRasymvalues among components was not significantly different between tumour and non-tumour groups. MTRasymin acute haemorrhage was significantly higher than those in the other regions regardless of underlying pathology.
  
  
  CONCLUSIONS
  Acute haemorrhages showed high MTRasymregardless of the underlying pathology, whereas subacute haemorrhages showed lower MTRasymthan acute haemorrhages. These results can aid in the interpretation of APT imaging in haemorrhage brain lesions.
  
  
  CONCLUSIONS
  • Acute haemorrhages show significantly higher MTRasymvalues than subacute haemorrhages. • MTRasymis higher in acute haemorrhage than in enhancing tumour tissue. • MTRasymin haemorrhage does not differ between tumorous and non-tumorous lesions.
authors.affiliation: Philips Korea, Seoul, Korea.|Korea Basic Science Institute, Chungcheongbuk-do, Korea.
authors.forename: Ha-Kyu
authors.initials: HK
authors.lastname: Jeong
authors.affiliation: Department of Radiology and Research Institute of Radiological Science, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Korea.|Yonsei Biomedical Research Institute, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Kyunghwa
authors.initials: K
authors.lastname: Han
authors.affiliation: Division of MRI Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Jinyuan
authors.initials: J
authors.lastname: Zhou
authors.affiliation: MR Clinical Science, Philips Healthcare, Cleveland, OH, USA.
authors.forename: Yansong
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Radiology and Research Institute of Radiological Science, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Korea.
authors.forename: Yoon Seong
authors.initials: YS
authors.lastname: Choi
authors.affiliation: Department of Radiology and Research Institute of Radiological Science, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Korea.
authors.forename: Seung-Koo
authors.initials: SK
authors.lastname: Lee
authors.affiliation: Department of Radiology and Research Institute of Radiological Science, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Korea. sungsoo@yuhs.ac.
authors.forename: Sung Soo
authors.identifier: http://orcid.org/0000-0002-0503-5558
authors.initials: SS
authors.lastname: Ahn
mesh_terms: D000208:Acute Disease; D000577:Amides; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D001931:Brain Mapping / Q000379:methods*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011522:Protons; D066127:White Matter / Q000000981:diagnostic imaging / Q000473:pathology
chemical_list: D000577:Amides; D011522:Protons
keywords: Amide proton transfer imaging; Brain neoplasms; Cerebral haemorrhage; Magnetic resonance imaging; Magnetization transfer