title: Early Postnatal Manganese Exposure Causes Lasting Impairment of Selective and Focused Attention and Arousal Regulation in Adult Rats.
abstract: Studies in children and adolescents have associated early developmental manganese (Mn) exposure with inattention, impulsivity, hyperactivity, and oppositional behaviors, but causal inferences are precluded by the correlational nature of the data and generally limited control for potential confounders.
  
  
  
  To determine whether early postnatal oral Mn exposure causes lasting attentional and impulse control deficits in adulthood, and whether continued lifelong Mn exposure exacerbates these effects, using a rat model of environmental Mn exposure.
  
  
  
  Neonates were exposed orally to 0, 25 or 50 mg Mn/kg/day during early postnatal life (PND 1-21) or throughout life from PND 1 until the end of the study. In adulthood, the animals were tested on a series of learning and attention tasks using the five-choice serial reaction time task.
  
  
  
  Early postnatal Mn exposure caused lasting attentional dysfunction due to impairments in attentional preparedness, selective attention, and arousal regulation, whereas associative ability (learning) and impulse control were spared. The presence and severity of these deficits varied with the dose and duration of Mn exposure.
  
  
  
  This study is the first to show that developmental Mn exposure can cause lasting impairments in focused and selective attention and arousal regulation, and to identify the specific nature of the impairments. Given the importance of attention and arousal regulation in cognitive functioning, these findings substantiate concerns about the adverse effects of developmental Mn exposure in humans. Citation: Beaudin SA, Strupp BJ, Strawderman M, Smith DR. 2017. Early postnatal manganese exposure causes lasting impairment of selective and focused attention and arousal regulation in adult rats. Environ Health Perspect 125:230-237; http://dx.doi.org/10.1289/EHP258.
authors.affiliation: Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, California, USA.
authors.forename: Stephane A
authors.initials: SA
authors.lastname: Beaudin
authors.forename: Barbara J
authors.initials: BJ
authors.lastname: Strupp
authors.forename: Myla
authors.initials: M
authors.lastname: Strawderman
authors.forename: Donald R
authors.initials: DR
authors.lastname: Smith
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001143:Arousal / Q000187:drug effects*; D001288:Attention / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects*; D004781:Environmental Exposure; D015386:Hazardous Substances / Q000633:toxicity*; D007858:Learning; D008345:Manganese / Q000633:toxicity*; D051381:Rats; D011930:Reaction Time
chemical_list: D015386:Hazardous Substances; D008345:Manganese