title: [Not Available].
abstract: Authors report a retrospective study of all cases of indoramin-only poisoning notified to the Paris poison Centre from 1986 to 2010. Fifty five cases of indoramin self-poisoning were included: 40 adults and 15 children. The mean supposed ingested dose was about 701mg±464mg. ECG showed a prolonged QTc interval (equal to or greater than 0.50s) in 30% of patients. The lowest observed dose for prolonged QTc was 625mg. This series includes two cases of seizures occurring around two hours after ingestion of 900 and 2 250mg of indoramin. A review of the literature showed cardiac disorders, with a delayed mechanism of action up until 18hours after ingestion. Therefore, rapid medical resuscitation and prolonged cardiac monitoring for at least 24hours after ingestion of 625mg are recommended.
authors.affiliation: Centre antipoison de Paris, Hôpital Fernand Widal, Paris, France. Electronic address: antoine.villa@lrb.aphp.fr.
authors.forename: Antoine F
authors.initials: AF
authors.lastname: Villa
authors.affiliation: Centre antipoison de Paris, Hôpital Fernand Widal, Paris, France.
authors.forename: Huan Tran
authors.initials: HT
authors.lastname: Hong
authors.affiliation: Centre antipoison de Paris, Hôpital Fernand Widal, Paris, France.
authors.forename: Hwee Min
authors.initials: HM
authors.lastname: Lee
authors.affiliation: Centre antipoison de Paris, Hôpital Fernand Widal, Paris, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Chataigner
authors.affiliation: Centre antipoison de Paris, Hôpital Fernand Widal, Paris, France.
authors.forename: Robert
authors.initials: R
authors.lastname: Garnier
keywords: ECG changes; QT; acute poisoning; convulsions; drug induced long QT syndrome; dysrhythmias; indoramin; indoramine; intoxication aiguë; modifications ECG; overdose; seizures; surdosage; syndrome QT d’origine médicamenteuse; torsades de pointes; troubles du rythme