title: Correlation between word recognition score and intracochlear new bone and fibrous tissue after cochlear implantation in the human.
abstract: Cochlear implantation is an effective, established procedure for patients with profound deafness. Although implant electrodes have been considered as biocompatible prostheses, surgical insertion of the electrode induces various changes within the cochlea. Immediate changes include insertional trauma to the cochlea. Delayed changes include a tissue response consisting of inflammation, fibrosis and neo-osteogenesis induced by trauma and an immunologic reaction to a foreign body. The goal of this study was to evaluate the effect of these delayed changes on the word recognition scores achieved post-operatively. Seventeen temporal bones from patients who in life had undergone cochlear implantation were prepared for light microscopy. We digitally calculated the volume of fibrous tissue and new bone within the cochlea using Amira(®) three-dimensional reconstruction software and assessed the correlations of various clinical and histologic factors. The postoperative CNC word score was positively correlated with total spiral ganglion cell count. Fibrous tissue and new bone were found within the cochlea of all seventeen specimens. The postoperative CNC word score was negatively correlated with the % volume of new bone within the scala tympani, scala media/vestibuli and the cochlea, but not with the % volume of fibrous tissue. The % volume of new bone in the scala media/vestibuli was positively correlated with the degree of intracochlear insertional trauma, especially trauma to the basilar membrane. Our results revealed that the % volume of new bone as well as residual total spiral ganglion cell count are important factors influencing post-implant hearing performance. New bone formation may be reduced by limiting insertional trauma and increasing the biocompatibility of the electrodes.
authors.affiliation: Human Otopathology Laboratory, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA; Department of Otolaryngology, Harvard Medical School, Boston, MA, USA.
authors.forename: Takefumi
authors.initials: T
authors.lastname: Kamakura
authors.affiliation: Human Otopathology Laboratory, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA; Department of Otolaryngology, Harvard Medical School, Boston, MA, USA. Electronic address: joseph_nadol@meei.harvard.edu.
authors.forename: Joseph B
authors.initials: JB
authors.lastname: Nadol
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001489:Basilar Membrane / Q000473:pathology*; D003051:Cochlea / Q000473:pathology*; D019929:Cochlear Implantation; D003054:Cochlear Implants; D003638:Deafness / Q000473:pathology; D004566:Electrodes; D004567:Electrodes, Implanted; D005260:Female; D006309:Hearing; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D012533:Scala Tympani / Q000601:surgery*; D054738:Scala Vestibuli; D013063:Speech Discrimination Tests; D013136:Spiral Ganglion / Q000473:pathology; D013701:Temporal Bone / Q000473:pathology*
keywords: Cochlear implant; Fibrous tissue; Human inner ear; Insertional trauma; New bone; Word recognition score