title: Acute kidney injury: Renal disease in the ICU.
abstract: Acute kidney injury (AKI) in the ICU frequently requires costly supportive therapies, has high morbidity, and its long-term prognosis is not as good as it has been presumed so far. Consequently, AKI generates a significant burden for the healthcare system. The problem is that AKI lacks an effective treatment and the best approach relies on early secondary prevention. Therefore, to facilitate early diagnosis, a broader definition of AKI should be established, and a marker with more sensitivity and early-detection capacity than serum creatinine - the most common marker of AKI - should be identified. Fortunately, new classification systems (RIFLE, AKIN or KDIGO) have been developed to solve these problems, and the discovery of new biomarkers for kidney injury will hopefully change the way we approach renal patients. As a first step, the concept of renal failure has changed from being a "static" disease to being a "dynamic process" that requires continuous evaluation of kidney function adapted to the reality of the ICU patient.
authors.affiliation: Intensive Care Medicine, Complejo Hospitalario Universitario Carlos Haya, Málaga, Spain.
authors.forename: G
authors.initials: G
authors.lastname: Seller-Pérez
authors.affiliation: Intensive Care Medicine, Hospital General Universitario de Castellón, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Más-Font
authors.affiliation: Intensive Care Medicine, HU Fundación Jiménez Díaz, Madrid, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Pérez-Calvo
authors.affiliation: Intensive Care Medicine, Hospital Universitario Principe de Asturias, Alcalá de Henares, Madrid, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Villa-Díaz
authors.affiliation: Intensive Care Medicine, Hospital Universitario Puerta del Mar, Cádiz, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Celaya-López
authors.affiliation: Intensive Care Medicine, Complejo Hospitalario Universitario Carlos Haya, Málaga, Spain. Electronic address: mehguci@gmail.com.
authors.forename: M E
authors.initials: ME
authors.lastname: Herrera-Gutiérrez
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis* / Q000628:therapy; D015415:Biomarkers; D003404:Creatinine; D006801:Humans; D007362:Intensive Care Units; D011379:Prognosis; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D003404:Creatinine
keywords: Acute Kidney Injury; Disfunción renal aguda; Enfermedad renal; Renal disease