title: Metabolic RemodeLIN of Pluripotency.
abstract: Cellular metabolism is a key regulator of cell fate, including fate in pluripotent stem cells. Now in Cell Stem Cell, Zhang et al. (2016) show that Lin28 controls the metabolic transition from naive to primed pluripotency by directly repressing oxidative metabolism genes and metabolic intermediates involved in epigenetic regulation independently of let-7.
authors.affiliation: Department of Biochemistry, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA.
authors.forename: Julie
authors.initials: J
authors.lastname: Mathieu
authors.affiliation: Department of Biochemistry, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA. Electronic address: hannele@uw.edu.
authors.forename: Hannele
authors.initials: H
authors.lastname: Ruohola-Baker
mesh_terms: D002454:Cell Differentiation / Q000235:genetics; D044127:Epigenesis, Genetic; D039904:Pluripotent Stem Cells