title: [Not Available].
abstract: The Optimal Dosing Times of Corticoids. The therapeutic use of Cortisol and its derivatives, anti-inflammatory corticoids, sets delicate problems to resolve because of Cortisol's physiological roles and its circadian rhythms. Cortisol and the majority of its derivatives have desirable and undesirable effects that are time-related administration. The chronothera- peutic optimisation to increase desirable effects and safety of corticoids is shown in the treatment of adrenocortical failure, congenital adrenal hyperplasia and asthma. The knowledge of physiological and physiopathological rhythms of asthma permitted to realize oral treatment optimisation by using a number of corticoids. This knowledge puts in a prominent position the advantages of ciclesonide: a new inhaled corticoid. A chronobiologic approach could be used in a classic optimisation which involves a molecule modification and inhalation like routes of administration.
authors.affiliation: Laboratoire de Pharmacologie, Faculté de Médecine, Monastir, Tunisie.
authors.forename: Dorrà
authors.initials: D
authors.lastname: Dridi
authors.affiliation: Unité d'Ecotoxicométrie, Chronobiométrie & Biomodélisation, Laboratoire de Biosurveillance de l'Environnement, Faculté des Sciences de Bizerte, Zarzouna, Tunisie.
authors.forename: Mossadok Ben
authors.initials: MB
authors.lastname: Attia
authors.affiliation: Laboratoire de Pharmacologie, Faculté de Médecine, Monastir, Tunisie.
authors.forename: Karim
authors.initials: K
authors.lastname: Aouam
authors.affiliation: Laboratoire de Pharmacologie, Faculté de Médecine, Tunis, Tunisie.
authors.forename: Kamel
authors.initials: K
authors.lastname: Bouzouita
authors.affiliation: Laboratoire de Pharmacologie, Faculté de Médecine, Monastir, Tunisie. Electronic address: naboughattas@yahoo.fr.
authors.forename: Naceur A
authors.initials: NA
authors.lastname: Boughattas
authors.affiliation: Unité de Chronobiologie, Fondation A. Rothschild, Paris, France.
authors.lastname: Alain Reinberg
keywords: Cortisol; asthme nocturne; ciclesonide; circadian rhythms; corticoadrenal; corticosteroids; corticostéroïdes; corticosurrénalienne; nocturnal asthma; pathologie; pathology; rythmes circadiens