title: Association of ADIPOQ, LEP, and FTO gene polymorphisms with large for gestational age infants.
abstract: OBJECTIVE
  The main objective of this study was to evaluate the effect of the ADIPOQ rs2241766, LEP rs7799039, and FTO rs9939609 polymorphisms on the birth weight status of Brazilian infants.
  
  
  METHODS
  This cross-sectional study was conducted in southern Brazil. Large for gestational age (LGA) newborns (n = 105), and the same number of small for gestational age/adequate for gestational age newborns, were included. Genotyping of the rs2241766, rs7799039, and rs9939609 polymorphisms was done by PCR-RFLP analysis. Logistic regression was used to investigate the association between LGA newborns and the presence of the polymorphisms.
  
  
  RESULTS
  Infants carrying the GG genotype of the rs7799039 polymorphism were 2.12 times more likely to be born LGA than those carrying the GA + AA genotypes (95% CI: 1.17-3.83). These results did not change substantially after adjusting for potential confounding variables (OR = 1.98; 95% CI 1.05-3.73) and adjustment for the three polymorphisms (OR = 1.98; 95% CI 1.05-3.74). Regarding the ADIPOQ polymorphism, newborns carrying the TG or GG genotype were 1.88 times more likely to be born LGA than those carrying the TT genotype, although this difference was not statistically significant (p = 0.082). No association was found between the FTO gene polymorphism and newborn weight status.
  
  
  CONCLUSIONS
  This study showed that the GG genotype of the LEP polymorphism rs7799039 is a risk factor for LGA infants. The exact role and mechanism of action of the GG genotype of this polymorphism in weight status control remain to be elucidated, and more studies are needed.
authors.affiliation: Post-Graduation Program in Health and Environment, University of Joinville Region, Joinville, Santa Catarina, 89.219-710, Brazil.
authors.forename: Caroline
authors.initials: C
authors.lastname: Kroll
authors.affiliation: School of Public Health, University of Alberta, Population Health Intervention Research Unit, Edmonton, Alberta, T6G 2T4, Canada.|Department of Physical Education, University of Joinville Region, Joinville, Santa Catarina, 89.219-710, Brazil.
authors.forename: Silmara S B S
authors.initials: SS
authors.lastname: Mastroeni
authors.affiliation: School of Public Health, University of Alberta, Population Health Intervention Research Unit, Edmonton, Alberta, T6G 2T4, Canada.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Veugelers
authors.affiliation: Post-Graduation Program in Health and Environment, University of Joinville Region, Joinville, Santa Catarina, 89.219-710, Brazil.|School of Public Health, University of Alberta, Population Health Intervention Research Unit, Edmonton, Alberta, T6G 2T4, Canada.|Department of Biological Sciences, University of Joinville Region Joinville, Santa Catarina, 89.219-710, Brazil.
authors.forename: Marco F
authors.identifier: http://orcid.org/0000-0001-9276-8866
authors.initials: MF
authors.lastname: Mastroeni
mesh_terms: D052242:Adiponectin / Q000235:genetics*; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO / Q000235:genetics*; D001724:Birth Weight / Q000235:genetics*; D001938:Brazil; D003430:Cross-Sectional Studies; D005838:Genotype; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D020738:Leptin / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D020738:Leptin; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human
keywords: ADIPOQ polymorphism; FTO polymorphism; LEP polymorphism; birth weight status; newborns