title: Level of HE4 is Correlated with Diagnosis of Struma Ovarii: A Case Report.
abstract: BACKGROUND Struma ovarii is a rare ovarian teratoma with non-specific clinical presentation that can mimic malignancy, especially when combined with the presence of ascites. Since the surgical procedures performed for benign and malignant tumors are quite different, pre-operative differential diagnosis is key. In this case report we compare the levels of biomarkers CA 125 and HE4 in the differential diagnosis of a suspicious ovarian tumor. CASE REPORT A 75-year-old woman with a palpable mass at the left adnexa, ascites, and high levels of CA 125, underwent a subtotal abdominal hysterectomy and bilateral salpingo-oophorectomy. Histology reported benign struma ovarii. CONCLUSIONS Even though transvaginal ultrasound and CA 125 levels suggested malignancy, HE4 measurements correctly diagnosed benignity.
authors.affiliation: Department of Obstetrics and Gynecology, Papageorgiou General Hospital, Thessaloniki, Greece.
authors.forename: Stavros
authors.initials: S
authors.lastname: Diavatis
authors.affiliation: Department of Obstetrics and Gynecology, Papageorgiou General Hospital, Thessaloniki, Greece.
authors.forename: Alexis
authors.initials: A
authors.lastname: Papanikolaou
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D018394:CA-125 Antigen / Q000097:blood; D003937:Diagnosis, Differential; D019160:Endosonography / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007044:Hysterectomy / Q000379:methods; D010535:Laparoscopy; D008279:Magnetic Resonance Imaging; D010051:Ovarian Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000601:surgery; D011506:Proteins / Q000378:metabolism*; D013330:Struma Ovarii / Q000097:blood / Q000175:diagnosis* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D014621:Vagina; D000081102:WAP Four-Disulfide Core Domain Protein 2
chemical_list: D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D011506:Proteins; D000081102:WAP Four-Disulfide Core Domain Protein 2; C569698:WFDC2 protein, human