title: Reference Intervals of Hematology and Clinical Chemistry Analytes for 1-Year-Old Korean Children.
abstract: BACKGROUND
  Reference intervals need to be established according to age. We established reference intervals of hematology and chemistry from community-based healthy 1-yr-old children and analyzed their iron status according to the feeding methods during the first six months after birth.
  
  
  METHODS
  A total of 887 children who received a medical check-up between 2010 and 2014 at Boramae Hospital (Seoul, Korea) were enrolled. A total of 534 children (247 boys and 287 girls) were enrolled as reference individuals after the exclusion of data obtained from children with suspected iron deficiency. Hematology and clinical chemistry analytes were measured, and the reference value of each analyte was estimated by using parametric (mean±2 SD) or nonparametric methods (2.5-97.5th percentile). Iron, total iron-binding capacity, and ferritin were measured, and transferrin saturation was calculated.
  
  
  RESULTS
  As there were no differences in the mean values between boys and girls, we established the reference intervals for 1-yr-old children regardless of sex. The analysis of serum iron status according to feeding methods during the first six months revealed higher iron, ferritin, and transferrin saturation levels in children exclusively or mainly fed formula than in children exclusively or mainly fed breast milk.
  
  
  CONCLUSIONS
  We established reference intervals of hematology and clinical chemistry analytes from community-based healthy children at one year of age. These reference intervals will be useful for interpreting results of medical check-ups at one year of age.
authors.affiliation: Department of Laboratory Medicine, Sheikh Khalifa Specialty Hospital, Ras Al Khaimah, United Arab Emirates.|Department of Laboratory Medicine, Seoul National University Hospital, Seoul, Korea.
authors.forename: Hye Ryun
authors.initials: HR
authors.lastname: Lee
authors.affiliation: Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.|Department of Laboratory Medicine, Boramae Hospital, Seoul, Korea.|Seoul Metropolitan Government Public Cord Blood Bank (Allcord), Seoul, Korea, Korea. jeannie@snu.ac.kr.
authors.forename: Sue
authors.initials: S
authors.lastname: Shin
authors.affiliation: Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.|Department of Laboratory Medicine, Boramae Hospital, Seoul, Korea.|Seoul Metropolitan Government Public Cord Blood Bank (Allcord), Seoul, Korea, Korea. slice@snu.ac.kr.
authors.forename: Jong Hyun
authors.initials: JH
authors.lastname: Yoon
authors.affiliation: Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.|Department of Laboratory Medicine, Boramae Hospital, Seoul, Korea.|Seoul Metropolitan Government Public Cord Blood Bank (Allcord), Seoul, Korea, Korea.
authors.forename: Eun Youn
authors.initials: EY
authors.lastname: Roh
authors.affiliation: Department of Pediatrics, Boramae Hospital, Seoul, Korea.
authors.forename: Ju Young
authors.initials: JY
authors.lastname: Chang
mesh_terms: D001942:Breast Feeding; D019963:Clinical Chemistry Tests / Q000592:standards*; D005260:Female; D006403:Hematologic Tests / Q000592:standards*; D006801:Humans; D007223:Infant; D007501:Iron / Q000097:blood* / Q000592:standards; D008297:Male; D012016:Reference Values; D056910:Republic of Korea
chemical_list: D007501:Iron
keywords: 1-Year-Old; Chemistry; Feeding; Hematology; Reference interval