title: Relationship Between Echocardiographically Evaluated Aortic Stiffness and Prolidase Activity in Aortic Tissue of Patients with Critical Coronary Artery Disease.
abstract: The aim of this study was to determine the relationship between echocardiographically evaluated aortic stiffness and prolidase activity in aortic tissue of patients with critical coronary occlusion.
  
  
  
  Thirty six patients with coronary artery disease (CAD) scheduled for CABG and 30 control patients with no CAD proven angiographically were enrolled in this study. Plasma prolidase activities were quantified spectrophotometrically. During performance of the proximal anastomoses in the study group, a piece of aortic tissue was taken by punch and tissue prolidase activity was quantified spectrophotometrically and also evaluated pathologically by prolidase immunostaining. Eventually, the correlation of plasma prolidase activity, aortic tissue prolidase activity and aortic prolidase immunohistochemical staining with aortic stiffness was studied.
  
  
  
  The correlation of aortic stiffness with aortic tissue prolidase activity (rs = 0.364; p = 0.029) and aortic prolidase immunohistochemical staining (rs = 0.354; p = 0.034) was significant in the study group. However, the correlation of plasma prolidase activity with aortic stiffness was not statistically significant (rs = 0.083; p = 0.292). Linear regression analysis showed that the aortic stiffness β index was significantly associated with aortic tissue prolidase activity (β = 0.354; p = 0.034) and statin usage (β = -0.334; 0.047) in the study group. Regression analysis revealed that ATPA and statin use were predictors of aortic stiffness, and API+ was found to be the predictor for ATPA (β = 0.449; p = 0.006).
  
  
  
  Aortic tissue prolidase activity was more significant than plasma prolidase activity and aortic tissue prolidase immunohistochemical staining in the relationship with aortic stiffness in the critical CAD group.
authors.affiliation: Department of Cardiovascular Surgery, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş, Turkey. Electronic address: drakocarslan@gmail.com.
authors.forename: Aydemir
authors.initials: A
authors.lastname: Koçarslan
authors.affiliation: Department of Pathology, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş, Turkey.
authors.forename: Sezen
authors.initials: S
authors.lastname: Koçarslan
authors.affiliation: Department of Cardiovascular Surgery, Harran University Faculty of Medicine, Şanliurfa, Turkey.
authors.forename: Mehmet Salih
authors.initials: MS
authors.lastname: Aydın
authors.affiliation: Department of Cardiology, Harran University Faculty of Medicine, Şanliurfa, Turkey.
authors.forename: İbrahim Halil
authors.initials: İH
authors.lastname: Altıparmak
authors.affiliation: Department of Cardiovascular Surgery, Bursa Treaning and Research Hospital, Bursa, Turkey.
authors.forename: Deniz
authors.initials: D
authors.lastname: Demir
authors.affiliation: Department of Biochemistry, Harran University Faculty of Medicine, Osmanbey Kampüsü, Şanliurfa, Turkey.
authors.forename: Hatice
authors.initials: H
authors.lastname: Sezen
authors.affiliation: Department of Anaesthesiology and Reanimation, Harran University Faculty of Medicine, Şanliurfa, Turkey.
authors.forename: Hasan Hüsnü
authors.initials: HH
authors.lastname: Yüce
authors.affiliation: Department of Cardiovascular Surgery, Harran University Faculty of Medicine, Şanliurfa, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Göz
mesh_terms: D001011:Aorta; D016022:Case-Control Studies; D001026:Coronary Artery Bypass; D023921:Coronary Stenosis / Q000097:blood / Q000503:physiopathology* / Q000628:therapy; D004150:Dipeptidases / Q000378:metabolism*; D004452:Echocardiography; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D059289:Vascular Stiffness
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D004150:Dipeptidases; C022449:proline dipeptidase
keywords: Aortic stiffness; Blood prolidase; Coronary artery disease; Immunohistochemistry; Tissue prolidase