title: Toward a More Efficient Implementation of Antifibrillation Pacing.
abstract: We devise a methodology to determine an optimal pattern of inputs to synchronize firing patterns of cardiac cells which only requires the ability to measure action potential durations in individual cells. In numerical bidomain simulations, the resulting synchronizing inputs are shown to terminate spiral waves with a higher probability than comparable inputs that do not synchronize the cells as strongly. These results suggest that designing stimuli which promote synchronization in cardiac tissue could improve the success rate of defibrillation, and point towards novel strategies for optimizing antifibrillation pacing.
authors.affiliation: Department of Mechanical Engineering, University of California Santa Barbara, Santa Barbara, CA 93106, United States of America.
authors.forename: Dan
authors.initials: D
authors.lastname: Wilson
authors.affiliation: Department of Mechanical Engineering, University of California Santa Barbara, Santa Barbara, CA 93106, United States of America.
authors.forename: Jeff
authors.initials: J
authors.lastname: Moehlis
mesh_terms: D000200:Action Potentials; D000465:Algorithms; D002304:Cardiac Pacing, Artificial; D003198:Computer Simulation; D004554:Electric Countershock / Q000295:instrumentation*; D006321:Heart; D006323:Heart Arrest / Q000628:therapy*; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D008955:Models, Cardiovascular; D015233:Models, Statistical; D009206:Myocardium / Q000378:metabolism; D011336:Probability