title: High consumption of tetracyclines for acne treatment among young Danish adults.
abstract: BACKGROUND
  Tetracyclines are used as acne treatment in adolescents worldwide. A large increase in the consumption of antimicrobial agents in Danish primary health care was recently linked to high levels of tetracycline use in adolescents.
  
  
  METHODS
  Here we closely examine how demographic factors influenced tetracycline use from 2005 to 2014 using consumption data from primary health care expressed as defined daily doses (DDDs) per 1000 inhabitants per day (DID) and number of persons treated per 1000 inhabitants.
  
  
  RESULTS
  From 2005 to 2013, tetracycline consumption increased by 54% followed by a decrease of 14% in 2014. Increases were especially pronounced in persons aged 15-39 years where nearly 9000 additional persons were treated with tetracyclines.
  
  
  CONCLUSIONS
  This study shows a long-lasting high consumption of tetracyclines in young Danes with a notable recent decrease breaking the otherwise worrying trend. To obtain a further decrease, focus on public awareness and suitable acne treatment guidelines are highly important.
authors.affiliation: a Antimicrobial Resistance Reference Laboratory and Surveillance Unit, Department of Microbiology & Infection Control , Statens Serum Institut , Copenhagen , Denmark ;|b Department of Infectious Disease Epidemiology , Statens Serum Institut , Copenhagen , Denmark ;
authors.forename: Katrin Gaardbo
authors.initials: KG
authors.lastname: Kuhn
authors.affiliation: c Data Communication and Research Services, Danish Health Data Authority , Copenhagen , Denmark.
authors.forename: Maja
authors.initials: M
authors.lastname: Laursen
authors.affiliation: a Antimicrobial Resistance Reference Laboratory and Surveillance Unit, Department of Microbiology & Infection Control , Statens Serum Institut , Copenhagen , Denmark ;
authors.forename: Anette M
authors.initials: AM
authors.lastname: Hammerum
authors.affiliation: a Antimicrobial Resistance Reference Laboratory and Surveillance Unit, Department of Microbiology & Infection Control , Statens Serum Institut , Copenhagen , Denmark ;
authors.forename: Robert L
authors.initials: RL
authors.lastname: Skov
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D003718:Denmark; D004363:Drug Utilization; D005260:Female; D006801:Humans; D008297:Male; D013754:Tetracyclines / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D013754:Tetracyclines
keywords: Antimicrobial agents; acne; consumption; resistance; tetracyclines