title: Effects of dorsolateral prefrontal cortex lesion on motor habit and performance assessed with manual grasping and control of force in macaque monkeys.
abstract: In the context of an autologous adult neural cell ecosystem (ANCE) transplantation study, four intact adult female macaque monkeys underwent a unilateral biopsy of the dorsolateral prefrontal cortex (dlPFC) to provide the cellular material needed to obtain the ANCE. Monkeys were previously trained to perform quantitative motor (manual dexterity) tasks, namely, the "modified-Brinkman board" task and the "reach and grasp drawer" task. The aim of the present study was to extend preliminary data on the role of the prefrontal cortex in motor habit and test the hypothesis that dlPFC contributes to predict the grip force required when a precise level of force to be generated is known beforehand. As expected for a small dlPFC biopsy, neither the motor performance (score) nor the spatiotemporal motor sequences were affected in the "modified-Brinkman board" task, whereas significant changes (mainly decreases) in the maximal grip force (force applied on the drawer knob) were observed in the "reach and grasp drawer" task. The present data in the macaque monkey related to the prediction of grip force are well in line with the previous fMRI data reported for human subjects. Moreover, the ANCE transplantation strategy (in the case of stroke or Parkinson's disease) based on biopsy in dlPFC does not generate unwanted motor consequences, at least as far as motor habit and motor performance are concerned in the context of a sequential grasping a small objects, which does not require the development of significant force levels.
authors.affiliation: Laboratory for sensorimotor and Multisensory Integration, Research Cluster Neurosciences, Department of Medicine, Fribourg Cognition Center, University of Fribourg, Chemin du Musée 5, 1700, Fribourg, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Badoud
authors.affiliation: Laboratory for sensorimotor and Multisensory Integration, Research Cluster Neurosciences, Department of Medicine, Fribourg Cognition Center, University of Fribourg, Chemin du Musée 5, 1700, Fribourg, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Borgognon
authors.affiliation: Laboratory for sensorimotor and Multisensory Integration, Research Cluster Neurosciences, Department of Medicine, Fribourg Cognition Center, University of Fribourg, Chemin du Musée 5, 1700, Fribourg, Switzerland.
authors.forename: J
authors.initials: J
authors.lastname: Cottet
authors.affiliation: Laboratory for sensorimotor and Multisensory Integration, Research Cluster Neurosciences, Department of Medicine, Fribourg Cognition Center, University of Fribourg, Chemin du Musée 5, 1700, Fribourg, Switzerland.
authors.forename: P
authors.initials: P
authors.lastname: Chatagny
authors.affiliation: Laboratory for sensorimotor and Multisensory Integration, Research Cluster Neurosciences, Department of Medicine, Fribourg Cognition Center, University of Fribourg, Chemin du Musée 5, 1700, Fribourg, Switzerland.
authors.forename: V
authors.initials: V
authors.lastname: Moret
authors.affiliation: Laboratory for sensorimotor and Multisensory Integration, Research Cluster Neurosciences, Department of Medicine, Fribourg Cognition Center, University of Fribourg, Chemin du Musée 5, 1700, Fribourg, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Fregosi
authors.affiliation: Laboratory for sensorimotor and Multisensory Integration, Research Cluster Neurosciences, Department of Medicine, Fribourg Cognition Center, University of Fribourg, Chemin du Musée 5, 1700, Fribourg, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Kaeser
authors.affiliation: Laboratory for sensorimotor and Multisensory Integration, Research Cluster Neurosciences, Department of Medicine, Fribourg Cognition Center, University of Fribourg, Chemin du Musée 5, 1700, Fribourg, Switzerland.
authors.forename: E
authors.initials: E
authors.lastname: Fortis
authors.affiliation: Laboratory for sensorimotor and Multisensory Integration, Research Cluster Neurosciences, Department of Medicine, Fribourg Cognition Center, University of Fribourg, Chemin du Musée 5, 1700, Fribourg, Switzerland.
authors.forename: E
authors.initials: E
authors.lastname: Schmidlin
authors.affiliation: Department of Neurosurgery, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
authors.forename: J
authors.initials: J
authors.lastname: Bloch
authors.affiliation: Department of Neurosurgery, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
authors.forename: J F
authors.initials: JF
authors.lastname: Brunet
authors.affiliation: Laboratory for sensorimotor and Multisensory Integration, Research Cluster Neurosciences, Department of Medicine, Fribourg Cognition Center, University of Fribourg, Chemin du Musée 5, 1700, Fribourg, Switzerland. eric.rouiller@unifr.ch.
authors.forename: E M
authors.initials: EM
authors.lastname: Rouiller
mesh_terms: D000818:Animals; D005260:Female; D007839:Functional Laterality; D006185:Habituation, Psychophysiologic / Q000502:physiology*; D018737:Hand Strength / Q000502:physiology*; D007091:Image Processing, Computer-Assisted; D008252:Macaca fascicularis; D008279:Magnetic Resonance Imaging; D009043:Motor Activity / Q000502:physiology*; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology*; D016059:Range of Motion, Articular / Q000502:physiology
keywords: Dorsolateral prefrontal cortex (dlPFC); Grip force control; Manual dexterity; Motor habits; Precision grip