title: Mammalian microRNAs and long noncoding RNAs in the host-bacterial pathogen crosstalk.
abstract: Gene expression regulation is a critical question in host-pathogen interactions, and RNAs act as key players in this process. In this review, we focus on the mammalian RNA response to bacterial infection, with a special interest on microRNAs and long non-coding RNAs. We discuss the role of cellular miRNAs in immunity, the implication of circulating miRNAs as well as the influence of the microbiome on the miRNA response. We also review how pathogens counteract the host miRNA expression. Interestingly, bacterial non-coding RNAs regulate host gene expression and conversely eukaryotic miRNAs may regulate bacterial gene expression. Overall, the characterization of RNA regulatory networks represents an emerging theme in the field of host pathogen interactions.
authors.affiliation: Institut Pasteur, Unité des Interactions Bactéries-Cellules, 75015 Paris, France; Inserm, U604, 75015 Paris, France; INRA, USC2020, 75015 Paris, France.
authors.forename: Mélodie
authors.initials: M
authors.lastname: Duval
authors.affiliation: Institut Pasteur, Unité des Interactions Bactéries-Cellules, 75015 Paris, France; Inserm, U604, 75015 Paris, France; INRA, USC2020, 75015 Paris, France. Electronic address: pascale.cossart@pasteur.fr.
authors.forename: Pascale
authors.initials: P
authors.lastname: Cossart
authors.affiliation: École Normale Supérieure, PSL Research University, CNRS, Inserm, Institut de Biologie de l'École Normale Supérieure (IBENS), Équipe Infection et Devenir de l'ARN, 75005 Paris, France; INRA, IBENS, 75005 Paris, France. Electronic address: alice.lebreton@ens.fr.
authors.forename: Alice
authors.initials: A
authors.lastname: Lebreton
mesh_terms: D000818:Animals; D001419:Bacteria / Q000235:genetics* / Q000254:growth & development / Q000276:immunology; D001424:Bacterial Infections / Q000235:genetics* / Q000276:immunology / Q000382:microbiology; D060467:Disease Resistance / Q000235:genetics; D005786:Gene Expression Regulation; D053263:Gene Regulatory Networks / Q000276:immunology; D054884:Host-Pathogen Interactions / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D008322:Mammals; D035683:MicroRNAs / Q000235:genetics* / Q000276:immunology; D016328:NF-kappa B / Q000235:genetics / Q000276:immunology; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000276:immunology; D015398:Signal Transduction
chemical_list: D035683:MicroRNAs; D016328:NF-kappa B; D062085:RNA, Long Noncoding
keywords: Bacteria; Host-pathogen; Regulatory network; lncRNA; microRNA