title: Smoking Cessation and the Microbiome in Induced Sputum Samples from Cigarette Smoking Asthma Patients.
abstract: Asthma is a common disease causing cough, wheezing and shortness of breath. It has been shown that the lung microbiota in asthma patients is different from the lung microbiota in healthy controls suggesting that a connection between asthma and the lung microbiome exists. Individuals with asthma who are also tobacco smokers experience more severe asthma symptoms and smoking cessation is associated with improved asthma control. In the present study we investigated if smoking cessation in asthma patients is associated with a change in the bacterial community in the lungs, examined using induced sputum. We found that while tobacco smokers with asthma have a greater bacterial diversity in the induced sputum compared to non-smoking healthy controls, smoking cessation does not lead to a change in the microbial diversity.
authors.affiliation: Technical University of Denmark, The Novo Nordisk Foundation Center for Biosustainability, Hørsholm, Denmark.
authors.forename: Christian
authors.initials: C
authors.lastname: Munck
authors.affiliation: Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
authors.forename: Jens
authors.initials: J
authors.lastname: Helby
authors.affiliation: Respiratory Research Unit, Bispebjerg University Hospital, Copenhagen, Denmark.
authors.forename: Christian G
authors.initials: CG
authors.lastname: Westergaard
authors.affiliation: Respiratory Research Unit, Bispebjerg University Hospital, Copenhagen, Denmark.
authors.forename: Celeste
authors.initials: C
authors.lastname: Porsbjerg
authors.affiliation: Respiratory Research Unit, Bispebjerg University Hospital, Copenhagen, Denmark.
authors.forename: Vibeke
authors.initials: V
authors.lastname: Backer
authors.affiliation: Aarhus University, Department of Environmental Science, Roskilde, Denmark.
authors.forename: Lars H
authors.initials: LH
authors.lastname: Hansen
mesh_terms: D000328:Adult; D001249:Asthma / Q000382:microbiology*; D005260:Female; D006801:Humans; D008297:Male; D064307:Microbiota / Q000187:drug effects; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D012907:Smoking / Q000009:adverse effects; D016540:Smoking Cessation; D013183:Sputum / Q000382:microbiology*; D055815:Young Adult
chemical_list: D012336:RNA, Ribosomal, 16S