title: Genomewide miRNA profiling of oral lichenoid disorders and oral squamous cell carcinoma.
abstract: OBJECTIVE
  To dissect the aberrant microRNA profile of oral lichenoid disorders (OLD) by analyzing the larger set of OLD samples tested so far.
  
  
  METHODS
  MicroRNA expression profiles were assessed using TLDA card in 32 samples (16 OLD, 8 OSCC, and 8 control). The findings were validated using RT-qPCR in an independent cohort of 91 samples.
  
  
  RESULTS
  We identified 20 differentially expressed microRNAs in OLD, of which several are functionally related to cell proliferation, response to organic substances, or immune processes. Further validation of the top-ranked microRNAs revealed that they were all aberrantly expressed in OLD.
  
  
  CONCLUSIONS
  We have identified a new microRNA signature associated with OLD that may provide a meaningful basis for better understanding the physiopathology of the disease. In addition, we validated seven microRNAs whose expression was shown to be higher in OLD tissue in comparison with the control and OSCC tissues.
authors.affiliation: Oral Medicine and Pathology, Department of Stomatology II, UFI 11/25, University of the Basque Country (UPV/EHU), Leioa, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Setién-Olarra
authors.affiliation: BIOMICs Research Group, Lascaray Research Center, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain.
authors.forename: N G
authors.initials: NG
authors.lastname: Bediaga
authors.affiliation: Oral Medicine and Pathology, Department of Stomatology II, UFI 11/25, University of the Basque Country (UPV/EHU), Leioa, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Acha-Sagredo
authors.affiliation: Oral Medicine and Pathology, Department of Stomatology II, UFI 11/25, University of the Basque Country (UPV/EHU), Leioa, Spain.
authors.forename: X
authors.initials: X
authors.lastname: Marichalar-Mendia
authors.affiliation: BIOMICs Research Group, Lascaray Research Center, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain.
authors.forename: M M
authors.initials: MM
authors.lastname: de Pancorbo
authors.affiliation: Oral Medicine and Pathology, Department of Stomatology II, UFI 11/25, University of the Basque Country (UPV/EHU), Leioa, Spain. josemanuel.aguirre@ehu.eus.
authors.forename: J M
authors.initials: JM
authors.lastname: Aguirre-Urizar
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D017512:Lichenoid Eruptions / Q000235:genetics / Q000378:metabolism*; D008297:Male; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D009059:Mouth Diseases / Q000235:genetics / Q000378:metabolism*; D009062:Mouth Neoplasms / Q000235:genetics / Q000378:metabolism*; D059467:Transcriptome
chemical_list: D035683:MicroRNAs
keywords: microRNA; oral cancer; oral lichenoid disorders