title: Yezo'otogirins D-H, Acylphloroglucinols and Meroterpenes from Hypericum yezoense.
abstract: Investigation of the methanolic extract from the aerial parts of Hypericum yezoense resulted in the isolation of three new acylphloroglucinols, yezo'otogirins D-F (1-3), and two new meroterpenes, yezo'otogirins G (4) and H (5). The structures of 1-5 were assigned on the basis of spectroscopic data. Yezo'otogirin D (1) is an acylphloroglucinol with a monoterpene moiety linked through an ether bond, while yezo'otogirins E (2) and F (3) are polyprenylated acylphloroglucinols possessing a tricyclic core. Yezo'otogirins G (4) and H (5) are linear meroterpenes with an enolized β-diketone moiety. Yezo'otogirin E (2) exhibited antimicrobial activity against Escherichia coli and Staphylococcus aureus.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Hokkaido University.
authors.forename: Naonobu
authors.initials: N
authors.lastname: Tanaka
authors.forename: Eri
authors.initials: E
authors.lastname: Tsuji
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Kashiwada
authors.forename: Jun'ichi
authors.initials: J
authors.lastname: Kobayashi
mesh_terms: D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects*; D020902:Hypericum / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D010696:Phloroglucinol / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D010936:Plant Extracts; D010696:Phloroglucinol