title: Meta-analysis of the efficacy of proton pump inhibitors for the symptoms of laryngopharyngeal reflux.
abstract: The objective of this study was to perform a systematic review and meta-analysis to assess the effectiveness of proton pump inhibitors (PPI) for reflux disease in adult patients with laryngopharyngeal symptoms. A comprehensive search of Cochrane Library, EMBASE, Ovid EBM Reviews, and PubMed was performed for English-language literature about laryngopharyngeal reflux (LPR), in September 2014. The papers were filtered using pre-defined inclusion and exclusion criteria. Eight papers were identified and included in this meta-analysis. The sample comprised a pooled total of 370 patients, of which 210 and 160 patients took PPIs and placebo, respectively. The difference between PPIs and placebo groups in overall improvement of symptoms in adult patients with LPR was not statistically significant (RR=1.22; 95%CI=0.93-1.58; P=0.149). The difference in cough improvement was also not significant between PPIs and placebo groups (RR=0.65; 95%CI=0.30-1.41; P=0.279).
authors.affiliation: Department of Otolaryngology, Ji'ning First People's Hospital of Shandong Province, Ji'ning, Shandong, China.
authors.forename: C
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Pediatric Dentistry, Ji'ning Stomatological Hospital of Shandong Province, Ji'ning, Shandong, China.
authors.forename: H
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Otolaryngology, Ping'du People's Hospital of Shandong Province, Ping'du, Shandong, China.
authors.forename: K
authors.initials: K
authors.lastname: Liu
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000627:therapeutic use*; D000328:Adult; D005260:Female; D006801:Humans; D057045:Laryngopharyngeal Reflux / Q000188:drug therapy*; D008297:Male; D015990:Placebo Effect; D054328:Proton Pump Inhibitors / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D054328:Proton Pump Inhibitors