title: [Not Available].
abstract: OBJECTIVE
  To describe the serious adverse drug reactions (ADR) in elderly subjects aged over 65 years and assess their preventability.
  
  
  METHODS
  A retrospective study was conducted at the Regional Pharmacovigilance Center of Champagne-Ardenne (northeast of France) between January and May 2013. Patients aged over 65 years who presented a serious ADR notified to the Regional Pharmacovigilance Center were included in the study.
  
  
  RESULTS
  Over the study period, 100 subjects were included in the study. The sex ratio was 0.96. Twenty seven percent of serious ADR were preventable. Off-label use accounted for 20% and non-compliance for 5%. Bleeding events were the most common serious ADR (36%). The drugs most frequently involved in serious ADR were antithrombotic agents (31.4%).
  
  
  CONCLUSIONS
  More than a quarter of serious ADR were preventable. Off-label use and non-compliance are the main causes identified in the occurrence of preventable serious ADR.
authors.affiliation: Centre Régional de Pharmacovigilance et de Pharmacoépidémiologie de Champagne-Ardenne, Centre Hospitalier Universitaire de Reims, Reims, France.
authors.forename: Lukshe
authors.initials: L
authors.lastname: Kanagaratnam
authors.affiliation: Centre Régional de Pharmacovigilance et de Pharmacoépidémiologie de Champagne-Ardenne, Centre Hospitalier Universitaire de Reims, Reims, France.
authors.forename: Malak Abou
authors.initials: MA
authors.lastname: Taam
authors.affiliation: Centre Régional de Pharmacovigilance et de Pharmacoépidémiologie de Champagne-Ardenne, Centre Hospitalier Universitaire de Reims, Reims, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Heng
authors.affiliation: Centre Régional de Pharmacovigilance et de Pharmacoépidémiologie de Champagne-Ardenne, Centre Hospitalier Universitaire de Reims, Reims, France.
authors.forename: Paul
authors.initials: P
authors.lastname: De Boissieu
authors.affiliation: Centre Régional de Pharmacovigilance et de Pharmacoépidémiologie de Champagne-Ardenne, Centre Hospitalier Universitaire de Reims, Reims, France.
authors.forename: Marie-Paule
authors.initials: MP
authors.lastname: Roux
authors.affiliation: Centre Régional de Pharmacovigilance et de Pharmacoépidémiologie de Champagne-Ardenne, Centre Hospitalier Universitaire de Reims, Reims, France. Electronic address: ttrenque@chu-reims.fr.
authors.forename: Thierry
authors.initials: T
authors.lastname: Trenque
keywords: adverse drug reactions; effet indésirable médicamenteux; elderly; pharmacovigilance; preventability; sujet âgé; évitabilité