title: Impact of statins on ALI/ARDS: A meta-analysis.
abstract: Statins may be beneficial in treating acute lung injury (ALI) or acute respiratory distress syndrome (ARDS), but their application remains controversial.
  
  
  
  This meta-analysis of published studies investigated their potential benefit in ALI/ARDS treatment.
  
  
  
  PubMed, EMBASE, Google Scholar and Cochrane databases were searched and all randomized controlled trials (RCT) and cohort studies with head-to-head comparison between statin and standard care were included.
  
  
  
  Three RCTs and six cohort studies were included. Overall, statins treatment had no significant effect on mortality compared with placebo (RCTs: OR = 0.99, 95% CI = 0.72, 1.37; cohorts: OR = 0.99, 95% CI = 0.71, 1.37). In addition, ventilator-free days were comparable between the two groups (RCTs: SMD = 0.08, 95% CI = -0.03, 0.19; cohorts: SMD = 0.06, 95% CI = -0.17, 0.29). The one-way sensitivity analysis confirmed the stability of results.
  
  
  
  The results did not show that statins had effects on mortality and ventilator-free days among ALI/ARDS patients. However, this meta-analysis is limited by the number of RCTs included.
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, China; Beijing Institute of Heart Lung and Blood Vessel Diseases, China.
authors.forename: Xia-Qing
authors.initials: XQ
authors.lastname: Gao
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, China; Beijing Institute of Heart Lung and Blood Vessel Diseases, China. Electronic address: liyf101@sohu.com.
authors.forename: Yan-Fang
authors.initials: YF
authors.lastname: Li
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, China; Beijing Institute of Heart Lung and Blood Vessel Diseases, China.
authors.forename: Zhi-Li
authors.initials: ZL
authors.lastname: Jiang
mesh_terms: D055371:Acute Lung Injury / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D012121:Respiration, Artificial / Q000706:statistics & numerical data; D012128:Respiratory Distress Syndrome / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
keywords: 5-Hydroxymethylfurfural (PubChem CID: 237332); ALI; ARDS; Glutaric acid (PubChem CID: 743); Statins; coenzyme A (PubChem CID: 87642)