title: [The clinical significance and changes of serum tumor necrosis factor and plasma endothelium in patients with OSAHS associated Type 2 diabetes mellites].
abstract: OBJECTIVE
  To investigate the significance of tumor necrosis factor-alpha (TNF-α) and plasma endothelium (ET) in pathophysiologic process of patients with obstructive sleep apnea hypopnea syndrome(OSAHS) with type 2 diabetes mellitus (T2DM).
  
  
  METHODS
  All observed subjects were divided into 4 groups. A number of 80 patients with OSAHS, 65 cases of OSAHS with T2DM patients, 20 patients with T2DM, and 32 cases of healthy control group were observed in this study. The serum levels of TNF-α and ET were detected by double antibody sandwich ELISA, the content of TNF-α and ET were compared between OSAHS group and OSAHS + T2DM group. It were also compared before and after treatment of CPAP or surgery.
  
  
  RESULTS
  TNF-α level is higher in OSAHS+T2DM group than that in the OSAHS group, T2DM group and the control group (P < 0.05); TNF-α level in OSAHS group and the T2DM group are higher than that in the control group (P < 0.05), but there was no difference in TNF-α level between the OSAHS group and the T2DM group. There was also no difference in ET level of the four groups. There were significant differences of TNF-α before and after treatment of CPAP or surgery in OSAHS group and OSAHS+T2DM group (P < 0.05). But there was no significant differences of ET before and after treatment of CPAP or surgery in the OSAHS+T2DM group (P > 0.05).
  
  
  CONCLUSIONS
  TNF-α may be involved in the development of OSAHS and T2DM, while ET may have little effect on the occurrence and development of OSAHS and T2DM.
authors.forename: Peilin
authors.initials: P
authors.lastname: Hui
authors.forename: Shuangbao
authors.initials: S
authors.lastname: Jia
authors.forename: Wei
authors.initials: W
authors.lastname: Ma
authors.forename: Lijun
authors.initials: L
authors.lastname: Zhao
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Wang
authors.forename: Xiaoquan
authors.initials: X
authors.lastname: Wei
authors.forename: Liya
authors.initials: L
authors.lastname: Zhou
authors.forename: Manke
authors.initials: M
authors.lastname: Dai
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Zhang
authors.forename: Yuping
authors.initials: Y
authors.lastname: Xie
mesh_terms: D000906:Antibodies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D016232:Endothelins / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000150:complications; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D000906:Antibodies; D016232:Endothelins; D014409:Tumor Necrosis Factor-alpha