title: Gastro-intestinal basidiobolomycosis in a 2-year-old boy: dramatic response to potassium iodide.
abstract: Gastro-intestinal basidiobolomycosis (GIB) is a rare fungal infection caused by Basidiobolus ranarum. Treatment includes surgical resection and long-term antifungal therapy. A 2.5-year-old boy presented with a 10-day history of abdominal pain, fever and diarrhoea, and a palpable abdominal mass was detected. Resection was undertaken and histology confirmed basidiobolomycosis. Treatment with amphotericin B and itraconazole was commenced, but the infection progressed and spread to involve the intestines, liver, ribs and lung, and also the abdominal wall after 6 months, requiring four operative procedures. Because of unresponsiveness to amphotericin and itraconazole, oral potassium iodide was added which resulted in complete resolution of the infection. Potassium iodide is an essential component of the treatment of systemic B. ranarum.
authors.affiliation: a Professor Alborzi Clinical Microbiology Research Center, Nemazee Hospital , Shiraz University of Medical Sciences , Shiraz , Iran.
authors.forename: Anahita
authors.initials: A
authors.lastname: Sanaei Dashti
authors.affiliation: b Pediatric Department , Urmia University of Medical Sciences , Urmia , Iran.
authors.forename: Amir
authors.initials: A
authors.lastname: Nasimfar
authors.affiliation: c Student Research Committee , Shiraz University of Medical Sciences , Shiraz , Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Hosseini Khorami
authors.affiliation: a Professor Alborzi Clinical Microbiology Research Center, Nemazee Hospital , Shiraz University of Medical Sciences , Shiraz , Iran.
authors.forename: Gholamreza
authors.initials: G
authors.lastname: Pouladfar
authors.affiliation: a Professor Alborzi Clinical Microbiology Research Center, Nemazee Hospital , Shiraz University of Medical Sciences , Shiraz , Iran.
authors.forename: Mohammad Rahim
authors.initials: MR
authors.lastname: Kadivar
authors.affiliation: d Transplant Research Center, Department of Pathology, Nemazee Hospital , Shiraz University of Medical Sciences , Shiraz , Iran.
authors.forename: Bita
authors.initials: B
authors.lastname: Geramizadeh
authors.affiliation: a Professor Alborzi Clinical Microbiology Research Center, Nemazee Hospital , Shiraz University of Medical Sciences , Shiraz , Iran.
authors.forename: Masoomeh
authors.initials: M
authors.lastname: Khalifeh
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage*; D002675:Child, Preschool; D020091:Entomophthorales / Q000302:isolation & purification*; D005767:Gastrointestinal Diseases / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology / Q000628:therapy*; D006651:Histocytochemistry; D006801:Humans; D008297:Male; D011193:Potassium Iodide / Q000008:administration & dosage*; D011860:Radiography, Abdominal; D013902:Radiography, Thoracic; D013514:Surgical Procedures, Operative; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D020096:Zygomycosis / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology / Q000628:therapy*
chemical_list: D000935:Antifungal Agents; D011193:Potassium Iodide
keywords: Amphotericin B; Fungal infection; Gastro-intestinal basidiobolomycosis; Itraconazole; Potassium iodide