title: A robust way to prepare blood-compatible and anti-fouling polyethersulfone membrane.
abstract: Functional copolymers were successfully grafted onto polyethersulfone (PES) membrane surfaces by free radical mechanism using ammonium persulfate (APS) as an initiator. The anti-coagulant and anti-fouling properties of the membranes were well controlled by changing the functional copolymer compositions. Attenuated total reflection-Fourier transforminfrared (ATR-FTIR), X-ray photoelectron spectrometer spectrum (XPS), water contact angles (WCAs), and scanning electron microscopy (SEM) images were used to characterize the membranes. The results of protein adsorption, clotting times, platelet adhesion and bacteria attachment indicated that the membranes had good blood-compatibility and/or anti-fouling ability. Meanwhile, the modification didn't cause an adverse effect on the membrane permeability. This new method provides a general, robust and flexible way to adjust membrane surface performance and potentially has wide applications.
authors.affiliation: College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Xie
authors.affiliation: College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.affiliation: College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.
authors.forename: Shuangsi
authors.initials: S
authors.lastname: Li
authors.affiliation: College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China. Electronic address: xita198906@163.com.
authors.forename: Tao
authors.initials: T
authors.lastname: Xiang
authors.affiliation: College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China. Electronic address: zhaochsh70@163.com.
authors.forename: Chang-Sheng
authors.initials: CS
authors.lastname: Zhao
mesh_terms: D000328:Adult; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology*; D057219:Biofouling / Q000517:prevention & control*; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008297:Male; D008567:Membranes, Artificial; D056951:Photoelectron Spectroscopy; D010969:Plastics / Q000737:chemistry / Q000494:pharmacology; D010973:Platelet Adhesiveness / Q000187:drug effects*; D058105:Polymerization; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology*; D013450:Sulfones / Q000737:chemistry / Q000494:pharmacology*; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D008567:Membranes, Artificial; D010969:Plastics; D011108:Polymers; D013450:Sulfones; C022840:polyether sulfone
keywords: Ammonium persulfate; Anti-fouling; Blood-compatibility; Surface-initiated Free radical polymerization