title: Severe Paracoccidioidomycosis in a 14-Year-Old Boy.
abstract: Paracoccidioidomycosis (PCM) is the most important systemic mycoses in Latin America. We describe a severe case of paracoccidioidomycosis in a 14-year-old boy, with a rapid disease progression. The fungal strain was isolated and inoculated into a T and/or B cell immunocompromised mice, which revealed a highly virulent strain. The case report presented herein emphasizes the importance of considering PCM in the differential diagnosis of patients with other infectious diseases in endemic areas and highlights a novel isolate.
authors.affiliation: Department of Clinical Pathology, School of Medical Sciences, State University of Campinas (UNICAMP), Rua Tessalia Vieira de Camargo, 126, Campinas, São Paulo, 13083-878, Brazil.
authors.forename: L P
authors.initials: LP
authors.lastname: Ruas
authors.affiliation: Department of Pediatrics, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
authors.forename: R M
authors.initials: RM
authors.lastname: Pereira
authors.affiliation: Department of Clinical Pathology, School of Medical Sciences, State University of Campinas (UNICAMP), Rua Tessalia Vieira de Camargo, 126, Campinas, São Paulo, 13083-878, Brazil.
authors.forename: F G
authors.initials: FG
authors.lastname: Braga
authors.affiliation: Department of Clinical Pathology, School of Medical Sciences, State University of Campinas (UNICAMP), Rua Tessalia Vieira de Camargo, 126, Campinas, São Paulo, 13083-878, Brazil.|School of Medicine, University of Fortaleza (UNIFOR), Fortaleza, Ceará, Brazil.
authors.forename: X T
authors.initials: XT
authors.lastname: Lima
authors.affiliation: Department of Clinical Pathology, School of Medical Sciences, State University of Campinas (UNICAMP), Rua Tessalia Vieira de Camargo, 126, Campinas, São Paulo, 13083-878, Brazil.
authors.forename: R L
authors.initials: RL
authors.lastname: Mamoni
authors.affiliation: Department of Pathology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
authors.forename: M L
authors.initials: ML
authors.lastname: Cintra
authors.affiliation: Department of Clinical Pathology, School of Medical Sciences, State University of Campinas (UNICAMP), Rua Tessalia Vieira de Camargo, 126, Campinas, São Paulo, 13083-878, Brazil.
authors.forename: A Z
authors.initials: AZ
authors.lastname: Schreiber
authors.affiliation: Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
authors.forename: V L G
authors.initials: VL
authors.lastname: Calich
authors.affiliation: Department of Clinical Pathology, School of Medical Sciences, State University of Campinas (UNICAMP), Rua Tessalia Vieira de Camargo, 126, Campinas, São Paulo, 13083-878, Brazil. heblotta@fcm.unicamp.br.
authors.forename: M H S L
authors.initials: MH
authors.lastname: Blotta
mesh_terms: D000293:Adolescent; D032761:Animal Experimentation; D000818:Animals; D001938:Brazil; D006651:Histocytochemistry; D006801:Humans; D016867:Immunocompromised Host; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D051379:Mice; D008853:Microscopy; D010228:Paracoccidioides / Q000302:isolation & purification* / Q000472:pathogenicity; D010229:Paracoccidioidomycosis / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology*; D016019:Survival Analysis
keywords: Case report; Fungal infection; Paracoccidioidomycosis; Virulent strain