title: The Influence of Neurodevelopmental Treatment on Transforming Growth Factor-β1 Levels and Neurological Remodeling in Children With Cerebral Palsy.
abstract: Neurodevelopmental treatment is an advanced therapeutic approach for the neural rehabilitation of children with cerebral palsy. Cerebral palsy represents a spectrum of neurological disorders primarily affecting gross motor function. The authors investigated the effects of neurodevelopmental treatment on serum levels of transforming growth factor-β1 (TGF-β1), a neuroprotective cytokine, and improvements to motor skills. Serum TGF-β1 levels and total score of the Gross Motor Function Measure-88 (GMFM-88) were significantly higher in children with cerebral palsy who underwent neurodevelopmental treatment compared to untreated patients (P < .01). Furthermore, the improved GMFM-88 total scores after neurodevelopmental treatment were significantly higher in children under the age of 3 with cerebral palsy than in older patients (P < .01). The authors demonstrate that the integration of TGF-β1 levels and GMFM-88 total score could be used to assess the efficacy of neurodevelopmental treatment. Moreover, the findings provide further scientific support for the early intervention and neurological rehabilitation of young children with cerebral palsy.
authors.affiliation: Department of Neurology, Renmin Hospital of Wuhan University, Wuhan Hubei Province, PR China.
authors.forename: Weiyuan
authors.initials: W
authors.lastname: Tao
authors.affiliation: Department of Neurology, Renmin Hospital of Wuhan University, Wuhan Hubei Province, PR China 39801229@qq.com.
authors.forename: Zuneng
authors.initials: Z
authors.lastname: Lu
authors.affiliation: Institute Neuopsychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, PR China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wen
mesh_terms: D015415:Biomarkers / Q000097:blood; D002547:Cerebral Palsy / Q000503:physiopathology* / Q000534:rehabilitation*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009043:Motor Activity; D000066530:Neurological Rehabilitation; D012720:Severity of Illness Index; D053773:Transforming Growth Factor beta1 / Q000097:blood*; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; C508960:TGFB1 protein, human; D053773:Transforming Growth Factor beta1
keywords: Gross Motor Function Measure; TGF-β1; cerebral palsy; neurodevelopmental treatment; remodeling