title: Mothers of Children with Autism have Different Rates of Cancer According to the Presence of Intellectual Disability in Their Child.
abstract: Autism spectrum disorder (ASD) and intellectual disability (ID) are neurodevelopmental disorders with strong genetic components. Increasingly, research attention has focused on whether genetic factors conveying susceptibility for these conditions, also influence the risk of other health conditions, such as cancer. We examined the occurrence of hospital admissions and treatment/services for cancer in mothers of children with ASD with or without ID compared with other mothers. After linking Western Australian administrative health databases, we used Cox regression to estimate the hazard ratios (HRs) of any hospitalisations and treatment/services for cancer in these groups of mothers. Mothers of children with ASD without ID had greater risk of admissions for cancer (HR 1.29 [95 % CI 1.1, 1.7]), and for treatment/services in particular (HR 1.41 [95 % CI 1.0, 2.0]), than mothers of children with no ASD/ID, while mothers of children with ASD with ID were no more likely to have a cancer-related hospital admission than other mothers. Mothers of children with autism without ID had increased risk of cancer, which may relate to common genetic pathways.
authors.affiliation: Telethon Kids Institute, University of Western Australia, Perth, Australia. jfairthorne@cfri.ca.|Child and Family Research Institute, University of British Columbia, Vancouver, Canada. jfairthorne@cfri.ca.
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: Fairthorne
authors.affiliation: Telethon Kids Institute, University of Western Australia, Perth, Australia.
authors.forename: Nicholas H
authors.initials: NH
authors.lastname: de Klerk
authors.affiliation: Telethon Kids Institute, University of Western Australia, Perth, Australia.
authors.forename: Helen M
authors.initials: HM
authors.lastname: Leonard
authors.affiliation: Telethon Kids Institute, University of Western Australia, Perth, Australia.
authors.forename: Andrew J O
authors.initials: AJ
authors.lastname: Whitehouse
mesh_terms: D000328:Adult; D000067877:Autism Spectrum Disorder / Q000523:psychology*; D002648:Child; D002675:Child, Preschool; D016208:Databases, Factual; D005260:Female; D006760:Hospitalization; D006801:Humans; D016247:Information Storage and Retrieval; D008607:Intellectual Disability / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D009035:Mothers / Q000706:statistics & numerical data*; D009369:Neoplasms / Q000453:epidemiology*; D016016:Proportional Hazards Models; D012720:Severity of Illness Index; D014904:Western Australia / Q000453:epidemiology; D055815:Young Adult
keywords: Autism; Cancer; Genetics; Intellectual disability; Parents