title: No difference in clinical outcome between patient-matched positioning guides and conventional instrumented total knee arthroplasty two years post-operatively: a multicentre, double-blind, randomised controlled trial.
abstract: OBJECTIVE
  We wished to compare the clinical outcome, as assessed by questionnaires and the rate of complications, in total knee arthroplasty (TKA) undertaken with patient-matched positioning guides (PMPGs) or conventional instruments.
  
  
  METHODS
  A total of 180 patients (74 men, 106 women; mean age 67 years) were included in a multicentre, adequately powered, double-blind, randomised controlled trial. The mean follow-up was 44 months (24 to 57).
  
  
  RESULTS
  There were no significant or clinically relevant differences between the two groups for all outcome measures (Knee Society Score, p = 0.807; Oxford Knee Score, p = 0.304; Western Ontario and McMaster osteoarthritis index, p = 0.753; visual analogue scale for pain, p = 0.227; EuroQol-5D-3L index score, p = 0.610; EuroQol-5D-3L VAS health, p = 0.968.) There was no difference in the rate of complications (p = 0.291).
  
  
  CONCLUSIONS
  PMPGs are already in relatively common use and their short-term clinical results are equal to conventional instrumented TKA. Cite this article: Bone Joint J 2016;98-B:939-44.
authors.affiliation: Zuyderland Medical Center, Prinsenbaan 145, 6104 BD, Koningsbosch, Netherlands / Dr. H. vd Hoffplein 1, 6162 BG Sittard-Geleen, The Netherlands.
authors.forename: B
authors.initials: B
authors.lastname: Boonen
authors.affiliation: Zuyderland Medical Center, Dr. H. vd Hoffplein 1, 6162 BG Sittard-Geleen, The Netherlands.
authors.forename: M G M
authors.initials: MG
authors.lastname: Schotanus
authors.affiliation: AZ Monica, Florent Pauwelslei 1, 2100 Deurne, Belgium.
authors.forename: B
authors.initials: B
authors.lastname: Kerens
authors.affiliation: Bogardeind 2, 5664 EH Geldrop, The Netherlands.
authors.forename: W
authors.initials: W
authors.lastname: van der Weegen
authors.affiliation: St. Anna Hospital, Bogardeind 2, 5664 EH Geldrop, The Netherlands.
authors.forename: H J
authors.initials: HJ
authors.lastname: Hoekstra
authors.affiliation: Zuyderland Medical Center, Dr. H. vd Hoffplein 1, 6162 BG Sittard-Geleen, The Netherlands.
authors.forename: N P
authors.initials: NP
authors.lastname: Kort
mesh_terms: D000368:Aged; D019645:Arthroplasty, Replacement, Knee / Q000295:instrumentation* / Q000379:methods*; D017076:Computer-Aided Design; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging / Q000601:surgery; D008297:Male; D020370:Osteoarthritis, Knee / Q000601:surgery; D011183:Postoperative Complications; D011300:Preoperative Care; D011795:Surveys and Questionnaires; D064232:Visual Analog Scale
keywords: Clinical outcome; Patient-specific guides; Randomised controlled trial; Total knee arthroplasty