title: The Effect of the Antioxidant Drug "U-74389G" on Creatinine Levels during Ischemia Reperfusion Injury in Rats.
abstract: OBJECTIVE
  The aim of this experimental study was to examine the effect of the antioxidant drug "U-74389G" on a rat model using an ischemia reperfusion protocol. The effect of U-74389G was studied biochemically by measuring mean blood creatinine levels.
  
  
  METHODS
  Forty rats were used in the study. Creatinine levels were measured at 60 min of reperfusion (groups A and C) or at 120 min of reperfusion (groups B and D), where groups A and B were controls and groups C and D received U-74389G administration.
  
  
  RESULTS
  U-74389G administration significantly decreased the predicted creatinine levels by 21.02 ± 5.06% (p = 0.0001). Reperfusion time non-significantly increased the predicted creatinine levels by 4.20 ± 6.12% (p = 0.4103). However, U-74389G administration and reperfusion time together produced a significant combined effect in decreasing the predicted creatinine levels by 11.69 ± 3.16% (p = 0.0005).
  
  
  CONCLUSIONS
  Independent of reperfusion time, U-74389G administration significantly decreased the creatinine levels in an ischemic rat model. This study demonstrates that short-term U-74389G administration improves renal function by increasing creatinine excretion.
authors.affiliation: Department of Obstetrics & Gynecology, Mesologi County Hospital, Etoloakarnania, Greece.
authors.forename: Constantinos
authors.initials: C
authors.lastname: Tsompos
authors.affiliation: Department of Obstetrics & Gynecology, Aretaieion Hospital, Greece.
authors.forename: Constantinos
authors.initials: C
authors.lastname: Panoulis
authors.affiliation: Department of Surgery, Ippokrateion General Hospital, Athens University, Attiki, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Toutouzas
authors.affiliation: Department of Surgery, Ippokrateion General Hospital, Athens University, Attiki, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Zografos
authors.affiliation: Experimental Research Centre ELPEN Pharmaceuticals, S.A. Inc., Co., Greece.
authors.forename: Apostolos
authors.initials: A
authors.lastname: Papalois
keywords: Creatinine; Ischemia; Reperfusion; U-74389G