title: Biosynthetic Study of Amphidinin A and Amphidinolide P.
abstract: The biogenetic origins of amphidinin A (1) and amphidinolide P (2) were investigated by feeding experiments with (13)C-labeled acetates. (13)C-NMR data of (13)C-enriched samples revealed that the all carbons of 1 and 2 were derived from acetates. The polyketide chain of 1 was formed from one triketide chain, two diketide chains, and three unusual isolated C1 units derived from C-2 of cleaved acetates, while the polyketide chain of 2 was formed from one pentaketide chain, two acetate units, and three unusual isolated C1 units derived from C-2 of cleaved acetates. The all branched C1 units of 1 and 2 were derived from C-2 of cleaved acetates.
authors.affiliation: Showa Pharmaceutical University.
authors.forename: Takaaki
authors.initials: T
authors.lastname: Kubota
authors.forename: Hayato
authors.initials: H
authors.lastname: Sato
authors.forename: Takahiro
authors.initials: T
authors.lastname: Iwai
authors.forename: Jun'ichi
authors.initials: J
authors.lastname: Kobayashi
mesh_terms: D004141:Dinoflagellida / Q000737:chemistry; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D008968:Molecular Conformation; D000097442:Amphidinolides
chemical_list: D005663:Furans; D018942:Macrolides; C000591100:amphidinin A; C407987:amphidinolide P; D000097442:Amphidinolides