title: Value of MR histogram analyses for prediction of microvascular invasion of hepatocellular carcinoma.
abstract: The objective is to explore the value of preoperative magnetic resonance (MR) histogram analyses in predicting microvascular invasion (MVI) of hepatocellular carcinoma (HCC).Fifty-one patients with histologically confirmed HCC who underwent diffusion-weighted and contrast-enhanced MR imaging were included. Histogram analyses were performed and mean, variance, skewness, kurtosis, 1th, 10th, 50th, 90th, and 99th percentiles were derived. Quantitative histogram parameters were compared between HCCs with and without MVI. Receiver operating characteristics (ROC) analyses were generated to compare the diagnostic performance of tumor size, histogram analyses of apparent diffusion coefficient (ADC) maps, and MR enhancement.The mean, 1th, 10th, and 50th percentiles of ADC maps, and the mean, variance. 1th, 10th, 50th, 90th, and 99th percentiles of the portal venous phase (PVP) images were significantly different between the groups with and without MVI (P <0.05), with area under the ROC curves (AUCs) of 0.66 to 0.74 for ADC and 0.76 to 0.88 for PVP. The largest AUC of PVP (1th percentile) showed significantly higher accuracy compared with that of arterial phase (AP) or tumor size (P <0.001).MR histogram analyses-in particular for 1th percentile for PVP images-held promise for prediction of MVI of HCC.
authors.affiliation: aDepartment of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China bShanghai Medical Imaging Institute, Shanghai, China cDepartment of Radiology, The Ningbo First Hospital, Ningbo, China.
authors.forename: Ya-Qin
authors.initials: YQ
authors.lastname: Huang
authors.forename: He-Yue
authors.initials: HY
authors.lastname: Liang
authors.forename: Zhao-Xia
authors.initials: ZX
authors.lastname: Yang
authors.forename: Ying
authors.initials: Y
authors.lastname: Ding
authors.forename: Meng-Su
authors.initials: MS
authors.lastname: Zeng
authors.forename: Sheng-Xiang
authors.initials: SX
authors.lastname: Rao
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D055806:Microvessels; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011237:Predictive Value of Tests; D012189:Retrospective Studies