title: Sporadic colorectal cancer: microbial contributors to disease prevention, development and therapy.
abstract: The gut microbiota has been hailed as an accessory organ, with functions critical to the host including dietary metabolic activities and assistance in the development of a proper functioning immune system. However, an aberrant microbiota (dysbiosis) may influence disease processes such as colorectal cancer. In this review, we discuss recent advances in our understanding of the contributions of the microbiota to prevention, initiation/progression, and treatment of colorectal cancer, with a major focus on biofilms and the antimicrobial and antitumoural immune response.
authors.affiliation: Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
authors.forename: Julia L
authors.initials: JL
authors.lastname: Drewes
authors.affiliation: Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
authors.forename: Franck
authors.initials: F
authors.lastname: Housseau
authors.affiliation: Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.|Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.|Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21287, USA.
authors.forename: Cynthia L
authors.initials: CL
authors.lastname: Sears
mesh_terms: D015179:Colorectal Neoplasms / Q000382:microbiology / Q000517:prevention & control* / Q000628:therapy; D018450:Disease Progression; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D064307:Microbiota