title: [Perioperative coagulation management during ascending aorta replacement on apixaban].
abstract: The direct oral anticoagulants (DOACs) present a valid therapeutic alternative to vitamin K antagonists in patients with non-valvular atrial fibrillation, for the prevention of venous thromboembolism, and for the treatment and prevention of the recurrence of pulmonary embolisms and deep vein thrombosis. Despite Idarucizumab as an antagonist of Dabigatran there are no other specific antidotes available yet. Therefore, perioperative coagulation management by DOACs is challenging in patients undergoing emergency surgical procedures with a high risk of bleeding complications. This case study describes the perioperative procedure during ascending aorta replacement after aortic dissection with apixaban administration.
authors.affiliation: Klinik für Anästhesiologie und Operative Intensivmedizin, Klinikum Augsburg, Stenglinstr. 2, 86156, Augsburg, Deutschland. christian.dumps@klinikum-augsburg.de.
authors.forename: C
authors.initials: C
authors.lastname: Dumps
authors.affiliation: Klinik für Anästhesiologie und Operative Intensivmedizin, Klinikum Augsburg, Stenglinstr. 2, 86156, Augsburg, Deutschland.
authors.forename: E
authors.initials: E
authors.lastname: Halbeck
authors.affiliation: Klinik für Anästhesiologie und Operative Intensivmedizin, Klinikum Augsburg, Stenglinstr. 2, 86156, Augsburg, Deutschland.
authors.forename: J
authors.initials: J
authors.lastname: Schimpf
authors.affiliation: Klinik für Anästhesiologie und Operative Intensivmedizin, Klinikum Augsburg, Stenglinstr. 2, 86156, Augsburg, Deutschland.
authors.forename: H
authors.initials: H
authors.lastname: Forst
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use*; D000931:Antidotes / Q000627:therapeutic use; D001011:Aorta / Q000601:surgery*; D001014:Aortic Aneurysm / Q000601:surgery*; D001777:Blood Coagulation / Q000187:drug effects*; D006801:Humans; D008297:Male; D019990:Perioperative Care; D011655:Pulmonary Embolism / Q000517:prevention & control; D011720:Pyrazoles / Q000037:antagonists & inhibitors / Q000627:therapeutic use*; D011728:Pyridones / Q000037:antagonists & inhibitors / Q000627:therapeutic use*; D012008:Recurrence; D013923:Thromboembolism / Q000097:blood / Q000517:prevention & control; D020246:Venous Thrombosis / Q000517:prevention & control
chemical_list: D000925:Anticoagulants; D000931:Antidotes; D011720:Pyrazoles; D011728:Pyridones; C522181:apixaban
keywords: Antidotes; Aortic dissection; Ascending aortic replacement; Direct oral anticoagulants; Perioperative coagulation management