title: Propranolol Reduces Cardiac Index But does not Adversely Affect Peripheral Perfusion in Severely Burned Children.
abstract: The aim of this study was to quantify the effect of propranolol on hemodynamic parameters assessed using the PiCCO system in burned children.
  
  
  
  We analyzed hemodynamic data from patients who were randomized to receive either propranolol (4 mg/kg/day) or placebo (control), which was initiated as a prospective randomized controlled trial. Endpoints were cardiac index (CI), percent predicted heart rate (%HR), mean arterial pressure (MAP), percent predicted stroke volume (%SV), rate pressure product (RPP), cardiac work (CW), systemic vascular resistance index (SVRI), extravascular lung water index (EVLWI), arterial blood gases, events of lactic acidosis, and mortality. Mixed multiple linear regressions were applied, and a 95% level of confidence was assumed.
  
  
  
  One hundred twenty-one burned children (control: n = 62, propranolol: n = 59) were analyzed. Groups were comparable in demographics, EVLWI, SVRI, %SV, arterial blood gases, Denver 2 postinjury organ failure score, incidence of lactic acidosis, or mortality. Percent predicted HR, MAP, CI, CW, and RPP were significantly reduced in the propranolol-treated group (P <0.01).
  
  
  
  Propranolol significantly reduces cardiogenic stress by reducing CI and MAP in children with severe burn injury. However, peripheral oxygen delivery was not reduced and events of lactic acidosis as well as organ dysfunction was not higher in propranolol treated patients.
authors.affiliation: *Department of Surgery, University of Texas Medical Branch, Galveston, Texas †Shriners Hospitals for Children-Galveston, Galveston, Texas ‡Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University of Graz, Graz, Austria §Sealy Center for Molecular Medicine and the Institute for Translational Sciences, University of Texas Medical Branch, Galveston, Texas ||School of Medicine, University of Texas Medical Branch, Galveston, Texas ¶Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas.
authors.forename: Paul
authors.initials: P
authors.lastname: Wurzer
authors.forename: Ludwik K
authors.initials: LK
authors.lastname: Branski
authors.forename: Robert P
authors.initials: RP
authors.lastname: Clayton
authors.forename: Gabriel
authors.initials: G
authors.lastname: Hundeshagen
authors.forename: Abigail A
authors.initials: AA
authors.lastname: Forbes
authors.forename: Charles D
authors.initials: CD
authors.lastname: Voigt
authors.forename: Clark R
authors.initials: CR
authors.lastname: Andersen
authors.forename: Lars-P
authors.initials: LP
authors.lastname: Kamolz
authors.forename: Lee C
authors.initials: LC
authors.lastname: Woodson
authors.forename: Oscar E
authors.initials: OE
authors.lastname: Suman
authors.forename: Celeste C
authors.initials: CC
authors.lastname: Finnerty
authors.forename: David N
authors.initials: DN
authors.lastname: Herndon
mesh_terms: D000293:Adolescent; D062186:Arterial Pressure / Q000187:drug effects; D002056:Burns / Q000401:mortality / Q000503:physiopathology*; D002302:Cardiac Output / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D015633:Extravascular Lung Water / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D011433:Propranolol / Q000627:therapeutic use*; D011446:Prospective Studies; D013318:Stroke Volume / Q000187:drug effects
chemical_list: D011433:Propranolol