title: Role of Autophagy and Apoptosis in the Postinfluenza Bacterial Pneumonia.
abstract: The risk of influenza A virus (IAV) is more likely caused by secondary bacterial infections. During the past decades, a great amount of studies have been conducted on increased morbidity from secondary bacterial infections following influenza and provide an increasing number of explanations for the mechanisms underlying the infections. In this paper, we first review the recent research progress that IAV infection increased susceptibility to bacterial infection. We then propose an assumption that autophagy and apoptosis manipulation are beneficial to antagonize post-IAV bacterial infection and discuss the clinical significance.
authors.affiliation: Department of Microbiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Qin
authors.affiliation: Department of Microbiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Microbiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, China.
authors.forename: Hongren
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Microbiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Luo
authors.affiliation: Department of Microbiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Microbiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, China.
authors.forename: Jiangzhou
authors.initials: J
authors.lastname: You
authors.affiliation: Department of Microbiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, China.
authors.forename: Baoning
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Microbiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, China; State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, Sichuan 610041, China.
authors.forename: Mingyuan
authors.initials: M
authors.lastname: Li
mesh_terms: D017209:Apoptosis / Q000276:immunology*; D001343:Autophagy / Q000276:immunology*; D016207:Cytokines / Q000276:immunology; D006801:Humans; D007251:Influenza, Human / Q000276:immunology / Q000382:microbiology* / Q000821:virology*; D018448:Models, Immunological; D018410:Pneumonia, Bacterial / Q000276:immunology / Q000382:microbiology* / Q000821:virology*; D015163:Superinfection / Q000276:immunology* / Q000382:microbiology* / Q000821:virology*
chemical_list: D016207:Cytokines