title: iRhom2 (Uncv) mutation blocks bulge stem cells assuming the fate of hair follicle.
abstract: iRhom2 is necessary for maturation of TNFα-converting enzyme, which is required for the release of tumor necrosis factor. In the previous study, we found that the iRhom2 (Uncv) mutation in N-terminal cytoplasmic domain-encoding region (iRhom2 (Uncv) ) leads to aberrant hair shaft and inner root sheath differentiation, thus results in a hairless phenotype in homozygous iRhom2 (Uncv/Uncv) BALB/c mice. In this study, we found iRhom2 mutation decreased hair matrix proliferation, however, iRhom2 (Uncv/Uncv) mice displayed hyperproliferation and hyperkeratosis in the interfollicular epidermis along with hypertrophy in the sebaceous glands. The number of bulge SCs was not altered and the hair follicle cycle is normal in iRhom2 (Uncv/Uncv) mice. The decreased proliferation in hair matrix but increased proliferation in epidermis and sebaceous glands in iRhom2 (Uncv/Uncv) mice may implying that iRhom2 (Uncv) mutation blocks bugle stem cells assuming the fate of hair follicle. This study identifies iRhom2 as a novel regulator for determination of keratinocyte lineages.
authors.affiliation: Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian, Beijing, 100850, People's Republic of China.
authors.forename: Leilei
authors.initials: L
authors.lastname: Yang
authors.affiliation: Institute of JingFeng Medical Laboratory Animal, 20 Dongdajie, Fengtai, Beijing, 100071, People's Republic of China.
authors.forename: Wenlong
authors.initials: W
authors.lastname: Li
authors.affiliation: Center for Disease Prevention and Control of Rocket Force, Beijing, 100094, People's Republic of China.
authors.forename: Bing
authors.initials: B
authors.lastname: Liu
authors.affiliation: Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian, Beijing, 100850, People's Republic of China.
authors.forename: Shaoxia
authors.initials: S
authors.lastname: Wang
authors.affiliation: Institute of JingFeng Medical Laboratory Animal, 20 Dongdajie, Fengtai, Beijing, 100071, People's Republic of China. zenglin1965@126.com.
authors.forename: Lin
authors.initials: L
authors.lastname: Zeng
authors.affiliation: Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, First Hospital Affiliated To the Chinese PLA General Hospital, Beijing, 100048, People's Republic of China. zcp666666@sohu.com.
authors.forename: Cuiping
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian, Beijing, 100850, People's Republic of China. leeyoung33@163.com.
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000235:genetics*; D002454:Cell Differentiation / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics; D000078404:Epidermal Cells; D004817:Epidermis / Q000473:pathology*; D018859:Hair Follicle / Q000166:cytology*; D017488:Hyperkeratosis, Epidermolytic / Q000235:genetics; D015603:Keratinocytes / Q000166:cytology*; D051379:Mice; D008807:Mice, Inbred BALB C; D018345:Mice, Knockout; D009154:Mutation; D012627:Sebaceous Glands / Q000166:cytology / Q000473:pathology*; D013234:Stem Cells / Q000166:cytology*
chemical_list: D002352:Carrier Proteins; C569468:iRhom2 protein, mouse
keywords: Differentiation; Hair follicle stem cell; Interfollicular epidermis; Sebaceous glands; iRhom2