title: Solitary pulmonary nodules due to non-tuberculous mycobacteriosis among 28 resected cases.
abstract: In some patients, non-tuberculous mycobacteria (NTM) infections manifest in solitary nodules (solitary nodular [SN] type) generally caused by Mycobacterium avium complex (MAC). In patients treated using surgical resection, the American Thoracic Society guidelines state that postoperative chemotherapy is not necessary in the absence of lesions, although there have been a few reports of such cases.
  
  
  
  Twenty-eight patients diagnosed with NTM who underwent solitary pulmonary nodule resection at Toneyama Hospital, Osaka, Japan, between January 2000 and October 2012 were enrolled. We evaluated the influence of the surgical procedure and chemotherapy on outcomes in this retrospective study.
  
  
  
  Of the 28 patients, 12 were males and 16 were females; the mean age was 58.6 ± 13.2 years. Twenty-five patients were asymptomatic and bronchoscopy was performed in 18; only 2 had a definitive diagnosis of NTM. The pathogen responsible was MAC in 27 patients and M. kansasii in 1. The surgical procedure used was wedge resection in 22 patients, segmentectomy in 1 and lobectomy in 5. Postoperative chemotherapy was administered to 9 patients. Twenty-six patients had no recurrence.
  
  
  
  We believe that wedge resection is a valid surgical intervention for SN type NTM; additional postoperative chemotherapy is unnecessary in cases with no residual lesions in the operated lung lobe.
authors.affiliation: Department of General Thoracic Surgery, National Hospital Organization Toneyama Hospital, Osaka, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Ose
authors.affiliation: Department of General Thoracic Surgery, National Hospital Organization Toneyama Hospital, Osaka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Maeda
authors.affiliation: Department of General Thoracic Surgery, National Hospital Organization Toneyama Hospital, Osaka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Takeuchi
authors.affiliation: Department of General Thoracic Surgery, National Hospital Organization Toneyama Hospital, Osaka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Susaki
authors.affiliation: Department of General Thoracic Surgery, National Hospital Organization Toneyama Hospital, Osaka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kobori
authors.affiliation: Department of General Thoracic Surgery, National Hospital Organization Toneyama Hospital, Osaka, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Taniguchi
authors.affiliation: Department of Respiratory Medicine, National Hospital Organization Toneyama Hospital, Osaka, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Maekura
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D009165:Mycobacterium Infections, Nontuberculous / Q000175:diagnosis / Q000382:microbiology / Q000601:surgery*; D015269:Mycobacterium avium Complex / Q000302:isolation & purification*; D019909:Mycobacterium kansasii / Q000302:isolation & purification*; D011013:Pneumonectomy; D012189:Retrospective Studies; D003074:Solitary Pulmonary Nodule / Q000175:diagnosis / Q000382:microbiology / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents