title: Plant Polysaccharides Attenuate Fluorouracil Toxicity for the Small Intestinal Epithelium.
abstract: Polysaccharides from Tussilago farfara L., Acorus calamus L., and Echinacea purpurea (L.) Moench attenuated the toxic effect of fl uorouracil on the small intestinal epithelium of mice with Lewis lung carcinoma. Addition of polysaccharides to chemotherapy protocols stimulated reparative regeneration processes in the small intestine damaged by the cytostatic treatment. No stimulating effects of the polysaccharides on tumor growth and metastasizing were revealed.
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia. safonova_7@mail.ru.
authors.forename: E A
authors.initials: EA
authors.lastname: Safonova
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: K A
authors.initials: KA
authors.lastname: Lopatina
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Vychuzhanina
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: L A
authors.initials: LA
authors.lastname: Ermolaeva
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: T G
authors.initials: TG
authors.lastname: Razina
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: E P
authors.initials: EP
authors.lastname: Zueva
mesh_terms: D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use / Q000633:toxicity*; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use / Q000633:toxicity*; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology; D007421:Intestine, Small / Q000187:drug effects / Q000473:pathology*; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D000964:Antimetabolites, Antineoplastic; D010936:Plant Extracts; D005472:Fluorouracil
keywords: fluorouracil; polysaccharides; small intestinal epithelium; toxicity