title: [Microbiological and therapeutic characteristics of confirmed neonatal sepsis at a hospital in Lima, Peru].
abstract: OBJECTIVE
  To describe the microbiological and therapeutic characteristics of confirmed neonatal sepsis, and determineits incidence and mortality, at the National Hospital Arzobispo Loayza (HNAL) from 2011 to 2012, Lima, Peru.
  
  
  METHODS
  Retrospective longitudinal study. It was performed a monitoring to newborns with probable sepsis, and assessed the results from positive blood cultures. The newborns' characteristics were obtained from medical records. The acumulated incidences of confirmed sepsis, mortality and fatality rates were determined. Quantitative variables were reported as men ± standard deviation or median (interquartile range). Qualitative variables were reported as relative frequencies and percentages.
  
  
  RESULTS
  The incidence of confirmed sepsis was 4.1 per 1 000 live births (95% confidence interval [CI]: 2.7-5.5). The mortality rate was 0.97 per 1 000 live births (95% CI: 0.29-1.63) and the fatality rate was 23.5% (95% CI: 9-37). The most commonly isolated organism was coagulase-negative Staphylococcus, followed by Staphylococcus aureus, both with high rates of oxacillin resistance (90% and 66.6%, respectively). A 67% of the newborns were treated using ampicillin/amikacin or ampicillin/cefotaxime. Antibiotics were changed in 58% of the newborns because of poor clinical/laboratory evolution or blood culture results. In most cases the seconds antibiotic was vancomycin (42.8%).
  
  
  CONCLUSIONS
  There is a high incidence of confirmed sepsis and a high fatality rate. The administered treatments were not consistent with the microbiological profiles.
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Alvarado-Gamarra
authors.forename: Katherine M
authors.initials: KM
authors.lastname: Alcalá-Marcos
authors.forename: Diego M
authors.initials: DM
authors.lastname: Abarca-Alfaro
authors.forename: Victoria
authors.initials: V
authors.lastname: Bao-Castro
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008137:Longitudinal Studies; D008297:Male; D000071074:Neonatal Sepsis / Q000378:metabolism / Q000628:therapy; D010568:Peru; D012189:Retrospective Studies; D018805:Sepsis; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000628:therapy; D013211:Staphylococcus aureus / Q000302:isolation & purification*
chemical_list: D000900:Anti-Bacterial Agents