title: Noninvasive detection of gastric cancer.
abstract: Gastric cancer (GC) is the fifth most common cancer and the third common cause of cancer death worldwide. Endoscopy is the most effective method for GC screening, but its application is limited by the invasion. Therefore, continuous efforts have been made to develop noninvasive methods for GC detection and promising results have been reported. Here, we review the advances in GC detection by protein and nucleic acid tumor markers, circulating tumor cells, and tumor-associated autoantibodies in peripheral blood. Some potential new noninvasive methods for GC detection are also reviewed, including exhaled breath analysis, blood spectroscopy analysis and molecular imaging.
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Jiangxi Institute of Gastroenterology and Hepatology, 17 Yongwai Zheng Street, Nanchang, Jiangxi, 330006, China.
authors.forename: Qin-Si
authors.initials: QS
authors.lastname: Wan
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Jiangxi Institute of Gastroenterology and Hepatology, 17 Yongwai Zheng Street, Nanchang, Jiangxi, 330006, China. yfyzkh@sina.com.
authors.forename: Kun-He
authors.initials: KH
authors.lastname: Zhang
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001944:Breath Tests; D004247:DNA / Q000097:blood; D004272:DNA, Mitochondrial / Q000032:analysis; D005750:Gastric Juice / Q000737:chemistry; D005773:Gastroscopy; D006801:Humans; D009360:Neoplastic Cells, Circulating; D013059:Spectrum Analysis, Raman; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging
chemical_list: D014408:Biomarkers, Tumor; D004272:DNA, Mitochondrial; D004247:DNA
keywords: Circulating cell-free nucleic acids; Exhaled breath analysis; Gastric cancer; Noninvasive detection; Spectroscopy analysis; Tumor markers