title: Dry and ripe fruit of Aegle marmelos. L: A potent source of antioxidant, lipoxygenase inhibitors and free radical scavenger.
abstract: The antioxidant, lipoxygenase inhibitory activities and free radical scavenging capacity of the crude extract, aqueous and some organic fractions of dry and ripe fruit of Aeglemarmelos. L were studied to understand the protective and therapeutic role for the use of the fruit as a remedy in different ailments. All the tested fractions and extracts showed to possess significant antioxidant, free radical scavenging capacity and lipoxygenase inhibitory potential. However, chloroform and aqueous fractions showed significant ability to quench radicals, to reduce ferric chloride and to inhibit soyabean lipoxygenase. Their antioxidant and lipoxygenase inhibition was estimated by IC50 values, for antioxidant ranging from 88-65% activity at concentration of 5-0.15μ/mL and similarly for lipoxygenase inhibition ranging from 89-69% at various concentrations of 5-0.15μ/mL, in chloroform and aqueous fractions respectively. The scavenger molecules in the dry and ripe fruit of A. marmelos may attribute to therapeutic and protective effect during different progressive stages of ailments.
authors.affiliation: Pharmacology Section, PCSIR Labs Complex, Karachi, Pakistan.
authors.forename: Atiqur
authors.initials: A
authors.lastname: Rahman
authors.affiliation: Pharmacology Section, PCSIR Labs Complex, Karachi, Pakistan.
authors.forename: Hina
authors.initials: H
authors.lastname: Imran
authors.affiliation: Pharmacology Section, PCSIR Labs Complex, Karachi, Pakistan.
authors.forename: Lubna
authors.initials: L
authors.lastname: Iqbal
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, Federal Urdu University of Arts, Science and Technology, Gulshan-e-Iqbal Campus, Karachi, Pakistan.
authors.forename: Syed Intasar Hussain
authors.initials: SI
authors.lastname: STaqvi
authors.affiliation: Pharmacology Section, PCSIR Labs Complex, Karachi, Pakistan.
authors.forename: Nudrat
authors.initials: N
authors.lastname: Fatima
authors.affiliation: Pharmacology Section, PCSIR Labs Complex, Karachi, Pakistan.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Yaqeen
mesh_terms: D045471:Aegle / Q000737:chemistry; D000975:Antioxidants / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D016166:Free Radical Scavengers; D016859:Lipoxygenase Inhibitors; D010936:Plant Extracts