title: Adipose-derived stem cells: A novel source of parathyroid cells for treatment of hypoparathyroidism.
abstract: Hypoparathyroidism is characterized by decreased function of the parathyroid glands with underproduction of parathyroid hormone (PTH), which can lead to low levels of calcium in the blood, often causing cramping and twitching of muscles or tetany, and several other symptoms. Severe hypocalcemia is a life-threatening condition. At present, both medical and surgical treatments are offered to improve the blood calcium, but they are not a cure. Adipose-derived stem cells (ADSCs), derived from the adipose tissue, are confirmed to be multipotent with adipogenic, chondrogenic, neurogenic, myogenic and osteogenic capabilities. Our hypothesis is that human ADSCs in culture can be differentiated into parathyroid cells, and used to reconstitute function.
authors.affiliation: Department of General Surgery, Xuanwu Hospital, Capital Medical University, No. 45 Changchunjie Street, Xuanwu District, Beijing, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of General Surgery, Beijing Tsinghua Changgung Hospital, Tsinghua University Medical Center, No. 168 Litang Road, Changping District, Beijing 102218, China. Electronic address: luobin@mail.tsinghua.edu.cn.
authors.forename: Bin
authors.initials: B
authors.lastname: Luo
mesh_terms: D017667:Adipocytes / Q000166:cytology*; D050156:Adipogenesis; D000273:Adipose Tissue / Q000166:cytology; D000818:Animals; D002118:Calcium / Q000097:blood; D002454:Cell Differentiation; D006801:Humans; D006996:Hypocalcemia / Q000097:blood; D007011:Hypoparathyroidism / Q000378:metabolism* / Q000628:therapy*; D008962:Models, Theoretical; D010012:Osteogenesis; D010280:Parathyroid Glands / Q000166:cytology*; D010281:Parathyroid Hormone / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology*
chemical_list: D010281:Parathyroid Hormone; D002118:Calcium