title: Molecules in seminal plasma related to platelets in preeclampsia.
abstract: Prostaglandins present in seminal fluid are actively involved in vascular and non-vascular smooth muscle maintenance, reproduction, and inflammatory processes. Seminal plasma contains molecules, such as oxylipins, which possess cell signaling functions. Several studies have shown that specific molecules in seminal fluid can increase passive diffusion, and cause interactions in the female reproductive tract. This may provoke a cascade of cellular and molecular changes in general health and certain diseases. This study examines the hypothesis that the molecules in seminal fluid are involved in platelet activity. The molecules diffuse through cells and membranes, affecting Hoxa 10, binding ganglioside pathways, and acting over platelet function. When these molecules are at low levels, they may trigger prothrombotic states, explaining the pathophysiology of haemostatic response, such as preeclampsia, and increased risk of cardiovascular disease.
authors.affiliation: Unit of Biochemistry ITO-UNAM, Oaxaca, Oax, Mexico; Research Center, UNAM-UABJO-Medicine, Oaxaca, Oax, Mexico.
authors.forename: Iván Antonio
authors.initials: IA
authors.lastname: García-Montalvo
authors.affiliation: Unit of Biochemistry ITO-UNAM, Oaxaca, Oax, Mexico; Research Center, UNAM-UABJO-Medicine, Oaxaca, Oax, Mexico.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Mayoral Andrade
authors.affiliation: Research Center, UNAM-UABJO-Medicine, Oaxaca, Oax, Mexico.
authors.forename: Laura
authors.initials: L
authors.lastname: Perez-Campos Mayoral
authors.affiliation: Research Center, UNAM-UABJO-Medicine, Oaxaca, Oax, Mexico.
authors.forename: Socorro
authors.initials: S
authors.lastname: Pina Canseco
authors.affiliation: Research Center, UNAM-UABJO-Medicine, Oaxaca, Oax, Mexico.
authors.forename: Ruth
authors.initials: R
authors.lastname: Martinez Cruz
authors.affiliation: Unit of Biochemistry ITO-UNAM, Oaxaca, Oax, Mexico.
authors.forename: Margarito
authors.initials: M
authors.lastname: Martínez-Cruz
authors.affiliation: Research Center, UNAM-UABJO-Medicine, Oaxaca, Oax, Mexico.
authors.forename: Edgar
authors.initials: E
authors.lastname: Zenteno
authors.affiliation: Research Center, UNAM-UABJO-Medicine, Oaxaca, Oax, Mexico.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Perez-Campos Mayoral
authors.affiliation: Research Center, UNAM-UABJO-Medicine, Oaxaca, Oax, Mexico.
authors.forename: Itandehui
authors.initials: I
authors.lastname: Gallegos Velasco
authors.affiliation: Unit of Biochemistry ITO-UNAM, Oaxaca, Oax, Mexico.
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Hernandez-Huerta
authors.affiliation: Research Center, UNAM-UABJO-Medicine, Oaxaca, Oax, Mexico.
authors.forename: Diana
authors.initials: D
authors.lastname: Matias-Perez
authors.affiliation: Unit of Biochemistry ITO-UNAM, Oaxaca, Oax, Mexico; Research Center, UNAM-UABJO-Medicine, Oaxaca, Oax, Mexico; Clinical Pathology Laboratory "Dr. Eduardo Pérez Ortega", Oaxaca, Oax, Mexico. Electronic address: perezcampos@prodigy.net.mx.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Pérez-Campos
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000378:metabolism; D004717:Endometrium / Q000378:metabolism; D005260:Female; D005732:Gangliosides / Q000378:metabolism; D007249:Inflammation; D008297:Male; D008962:Models, Theoretical; D054883:Oxylipins / Q000378:metabolism; D010979:Platelet Function Tests; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D011453:Prostaglandins / Q000378:metabolism; D012661:Semen / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D005732:Gangliosides; D054883:Oxylipins; D011453:Prostaglandins
keywords: Gangliosides; Oxylipins; Platelets; Preeclampsia; Prostaglandins; Seminal fluid