title: Testosterone replacement therapy improves health-related quality of life for patients with late-onset hypogonadism: a meta-analysis of randomized controlled trials.
abstract: Although testosterone replacement therapy can restore serum testosterone concentrations to normal level in late-onset hypogonadism patients, whether it can improve patients' quality of life remains uncertain. Therefore, we perform a meta-analysis of randomized controlled trials on this issue. Five randomized controlled trials total 1,212 patients were included. Fixed-effect model was used to calculate the weighted mean difference of score of Aging Males' Symptom rating scale. Our result reveals that testosterone replacement therapy improves patients' health-related quality of life in terms of the decrease in the AMS total score [WMD = -2.96 (-4.21, -1.71), p < .00001] and the psychological [WMD = -0.89 (-1.41, -0.37), p = .0008], somatic [WMD = -0.89 (-1.41, -0.37), p = .0008] and sexual [WMD = -1.29 (-1.75, -0.83), p < .00001] subscale score.
authors.affiliation: Department of Urology, The Second Xiangya Hospital, Central South University, Yuhua District, Changsha City, Hunan, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Nian
authors.affiliation: Department of Urology, The Second Xiangya Hospital, Central South University, Yuhua District, Changsha City, Hunan, China.
authors.forename: M
authors.initials: M
authors.lastname: Ding
authors.affiliation: Department of Urology, The Second Xiangya Hospital, Central South University, Yuhua District, Changsha City, Hunan, China.
authors.forename: S
authors.initials: S
authors.lastname: Hu
authors.affiliation: Department of Urology, Shekou People's Hospital, Nanshan District, Shenzhen City, Guangdong Province, China.
authors.forename: H
authors.initials: H
authors.lastname: He
authors.affiliation: Department of Urology, The Second Xiangya Hospital, Central South University, Yuhua District, Changsha City, Hunan, China.
authors.forename: S
authors.initials: S
authors.lastname: Cheng
authors.affiliation: Department of Urology, The Second Xiangya Hospital, Central South University, Yuhua District, Changsha City, Hunan, China.
authors.forename: L
authors.initials: L
authors.lastname: Yi
authors.affiliation: Department of Urology, The Second Xiangya Hospital, Central South University, Yuhua District, Changsha City, Hunan, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Urology, The Second Xiangya Hospital, Central South University, Yuhua District, Changsha City, Hunan, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000368:Aged; D000728:Androgens / Q000097:blood / Q000627:therapeutic use*; D020249:Hormone Replacement Therapy / Q000379:methods*; D006801:Humans; D007006:Hypogonadism / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D000067562:Late Onset Disorders / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D008297:Male; D015233:Models, Statistical; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic; D013739:Testosterone / Q000097:blood / Q000627:therapeutic use*
chemical_list: D000728:Androgens; D013739:Testosterone
keywords: Aging Males' Symptom rating scale; health-related quality of life; late-onset hypogonadism; testosterone deficiency; testosterone replacement therapy