title: 10-DHGD ameliorates cisplatin-induced nephrotoxicity in rats.
abstract: Organs subjected to chronic injuries may develop tissue fibrosis. Several factors contribute to the combat injurious stimuli to repair, heal and alleviate any disturbance. Secretion of chemokines, migration of inflammatory cells to the affected site and activation of fibroblast for production of extracellular matrix (ECM) are examples. Recently, few studies have delt with 10-dehydrogingerdione (10-DHGD), one of the active constituent of ginger extracts that has been published. This constituent proved to be potent antioxidant, anti-inflammatory, cholesterol ester transfer protein (CETP) inhibitor, indeed, a hypolipemic agent. It has been selected in the present study as a natural anti-inflammatory agent to combat inflammation, nephrotoxicity and renal fibrosis-induced by cisplatin. Renal fibrosis state demonstrated a significant increase in creatinine, urea, nuclear factor kappa (NF-kB), insulin like growth factor I (IGF-I), fibroblast growth factor-23 (FGF-23) along with a significant decrease of hepatocytes growth factor (HGF), renal glutathione (GSH) and in confirm to histopathological examination of kidney tissue. Administration of 10-DHGD orally daily for 4 weeks resulted in a significant improvement of both the biomarkers studied in addition to the histopathological profile of the renal tissues.
  
  
  CONCLUSIONS
  10-DHGD exhibited a marked anti-inflammatory potential, alleviated to a great extent of nephrotoxicity and renal fibrosis induced by cisplatin.
authors.affiliation: Department of Biochemistry, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt. Electronic address: mmelseweidy@yahoo.com.
authors.forename: Mohamed M
authors.initials: MM
authors.lastname: Elseweidy
authors.affiliation: Department of Biochemistry, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt.
authors.forename: Mohamed S
authors.initials: MS
authors.lastname: Zaghloul
authors.affiliation: Department of Biochemistry, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt.
authors.forename: Nahla N
authors.initials: NN
authors.lastname: Younis
mesh_terms: D000818:Animals; D002945:Cisplatin / Q000009:adverse effects*; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood; D005355:Fibrosis; D006139:Guaiacol / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D017228:Hepatocyte Growth Factor / Q000097:blood; D007249:Inflammation / Q000473:pathology; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced* / Q000188:drug therapy*; D007677:Kidney Function Tests; D008297:Male; D016328:NF-kappa B / Q000097:blood; D017208:Rats, Wistar
chemical_list: C561631:(10)-dehydrogingerdione; D016328:NF-kappa B; D005346:Fibroblast Growth Factors; D017228:Hepatocyte Growth Factor; D007334:Insulin-Like Growth Factor I; D006139:Guaiacol; D000089703:Fibroblast Growth Factor-23; D002945:Cisplatin
keywords: 10-Dehydrogingerdione; Cisplatin; Nephrotoxicity; Renal fibrosis