title: 5-Fluoro-Uracil and Low Molecular Weight Heparin in the Management of Proliferative Vitreo-retinopathy.
abstract: BACKGROUND
  Proliferative vitreo-retinopathy (PVR) is the most common cause of failed repair of a primary rhegmatogenous retinal detachment (RRD). The success rates for the surgery of complicated RRD has doubled with improved vitreous techniques from 35-40% to approximately 65-75% at six months. However, despite these advances, recurrent vitreo-retinal traction leads to re-detachment in more than one-fourths of the initially successful cases. The use of adjunctive treatments to prevent cellular proliferation holds promise for the prevention of PVR or recurrences after surgery. One focus has been on the use of intra-vitreal antimetabolites to prevent the occurrence of PVR.
  
  
  METHODS
  Thirty patients of complicated retinal detachment associated with PVR, C1 or more were managed by vitreo-retinal (VR) surgery with the addition of 250 μg / ml of 5-fluorouracil (5FU) and 1 IU / ml of low molecular weight heparin (LMWH) to the vitreous infusion. The patients were examined for any evidence of PVR till 180 days as also for any systemic or other ophthalmic complication.
  
  
  RESULTS
  Out of the 30 cases in the study group, 25 (83.34%) cases had retinal settlement at the end of six weeks, which is similar to the outcomes of conventional VR surgery. There was no case of any serious complication.
  
  
  CONCLUSIONS
  The addition of LMWH and 5FU did not enhance the outcome of VR surgery.
authors.affiliation: Associate Professor, (Department of Ophthalmology), AFMC, Pune-40.
authors.forename: V S
authors.initials: VS
authors.lastname: Gurunadh
authors.affiliation: Professor & Head (Department of Ophthalmology), AFMC, Pune-40.
authors.forename: A
authors.initials: A
authors.lastname: Banarji
authors.affiliation: Associate Professor, (Department of Ophthalmology), AFMC, Pune-40.
authors.forename: S
authors.initials: S
authors.lastname: Patyal
authors.affiliation: Senior Advisor (Ophthalmology), Command Hospital (Northern Command), C/o 56 APO.
authors.forename: T S
authors.initials: TS
authors.lastname: Ahluwalia
authors.affiliation: Senior Advisor (Ophthalmology) AFCME, Delhi Cantt.
authors.forename: A K
authors.initials: AK
authors.lastname: Upadhyay
authors.affiliation: CMO, Sitapur Eye Hospital, Sitapur (UP).
authors.forename: M
authors.initials: M
authors.lastname: Bhadauria
keywords: 5-fluorouracil; Low molecular weight heparin; Proliferative vitreo-retinopathy; Rhegmatogenons retinal detachment