title: Experience with Bilateral Risk-Reducing Mastectomy for an Unaffected BRCA Mutation Carrier.
abstract: Women with BRCA1/2 mutations have a high risk of breast cancer and may opt for risk-reducing mastectomy (RRM). We report a 38-year-old Japanese woman who was diagnosed as a BRCA2 mutation carrier. She underwent prophylactic bilateral skin-sparing mastectomy (SSM) with excision of the nipple and preservation of the areola skin. It is unclear whether a bilateral RRM leads to better survival compared with intensive surveillance. The oncological risk associated with the presence of remnant breast glandular tissue after SSM or nipple-sparing mastectomy has been obscure. We report the first case of RRM for a Japanese BRCA mutation carrier and provide a literature review on risk management for BRCA mutation carriers with a focus on the concepts and procedures of RRM.
authors.affiliation: Department of Breast Surgery, Kitano Hospital Breast Center, The Tazuke Kohukai Medical Research Institute, Osaka, Japan.
authors.forename: Yurina
authors.initials: Y
authors.lastname: Maeshima
authors.affiliation: Department of Breast Surgery, Kitano Hospital Breast Center, The Tazuke Kohukai Medical Research Institute, Osaka, Japan.
authors.forename: Kumiko
authors.initials: K
authors.lastname: Oseto
authors.affiliation: Department of Breast Surgery, Kitano Hospital Breast Center, The Tazuke Kohukai Medical Research Institute, Osaka, Japan.
authors.forename: Ryohei
authors.initials: R
authors.lastname: Katsuragi
authors.affiliation: Department of Breast Surgery, Kitano Hospital Breast Center, The Tazuke Kohukai Medical Research Institute, Osaka, Japan.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Yoshimoto
authors.affiliation: Department of Breast Surgery, Kitano Hospital Breast Center, The Tazuke Kohukai Medical Research Institute, Osaka, Japan.
authors.forename: Sachiko
authors.initials: S
authors.lastname: Takahara
authors.affiliation: Department of Breast Surgery, Kitano Hospital Breast Center, The Tazuke Kohukai Medical Research Institute, Osaka, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Yamauchi
keywords: BRCA2; Genes; Prophylactic surgical procedure; Subcutaneous mastectomy