title: Chitotriosidase as a novel biomarker of early atherosclerosis in hemodialysis patients.
abstract: Increasing evidence suggests that inflammation and increased macrophage activity have a central role in pathogenesis of atherosclerosis. It is shown that chitotriosidase (CHIT-1) is a marker of macrophage activity in atherosclerotic plaque, and is found associated with severity of atherosclerotic lesion. There is no data about CHIT-1 activity of hemodialysis patients in the literature. Thus, we hypothesized that in hemodialysis patients, CHIT-1 levels might be a novel biomarker in early atherosclerosis.
  
  
  
  Forty-five hemodialysis patients were included in the study (age: 61.93 ± 13.34). Intima media thickness (IMT) was evaluated with high-resolution B-mode ultrasonography. Biomarker levels were measured in serum of patients.
  
  
  
  We found positive correlation among IMT, age (R: 0.426, P: 0.004) and, CHIT-1 value (R: 0.462, P: 0.001) in spearman correlation analysis. When age, CRP, creatinine, P, Alb, CHIT-1 were chosen as measures that can effect IMT in multiple regression model, IMT level was related with CHIT-1 (Beta: 0,396, P: 0.012) and age (Beta: 0,313 P: 0,048) independently.
  
  
  
  In conclusion, this is the first report showing that serum CHIT-1 level was related independently with carotid IMT in hemodialysis patients. This biomarker might have an unknown role in the development of atherosclerosis during uremia.
authors.affiliation: Department of Nephrology, Ahi Evran School of Medicine, Kırşehir, Turkey.
authors.forename: Aydın
authors.initials: A
authors.lastname: Güçlü
authors.affiliation: Department of Nephrology, Gülhane School of Medicine, Ankara, Turkey.
authors.forename: Mahmut Ilker
authors.initials: MI
authors.lastname: Yilmaz
authors.affiliation: Department of Radiology, Ahi Evran School of Medicine, Kırşehir, Turkey.
authors.forename: Turgut Tursem
authors.initials: TT
authors.lastname: Tokmak
authors.affiliation: Department of Nephrology, Gülhane School of Medicine, Ankara, Turkey.
authors.forename: Hilmi Umut
authors.initials: HU
authors.lastname: Unal
authors.affiliation: Department of Nephrology, Gülhane School of Medicine, Ankara, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Karaman
authors.affiliation: Department of Nephrology, Gülhane School of Medicine, Ankara, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gezer
authors.affiliation: Department of Biochemistry, Gülhane School of Medicine, Ankara, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Taş
authors.affiliation: Department of Biochemistry, Gülhane School of Medicine, Ankara, Turkey.
authors.forename: İbrahim
authors.initials: İ
authors.lastname: Aydin
authors.affiliation: Department of physiology, Dumlupınar School of Medicine, Kütahya, Turkey.
authors.forename: Raziye
authors.initials: R
authors.lastname: Akçılar
authors.affiliation: Dialysis Unit, Ahi Evran School of Medicine, Kırşehir, Turkey.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Dursun
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000097:blood*; D015415:Biomarkers / Q000097:blood*; D005260:Female; D006596:Hexosaminidases / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects*; D012307:Risk Factors; D055815:Young Adult
chemical_list: D015415:Biomarkers; D006596:Hexosaminidases; C086400:chitotriosidase
keywords: Chitotriosidase (CHIT-1); atherosclerosis; hemodialysis; intima media thickness