title: The effect of synthetic ceramide analogues on gastritis and esophagitis in rats.
abstract: The effects of ceremide analogues on esophagitis and gastritis in rats were examined. Gastritis induced by indomethacin was significantly reduced after CY3325 and CY3723 treatment, whereas other analogues had no effect. The amount of malondialdehyde in gastritis was significantly reduced by CY3325 or CY 3723. CY3325 or CY 3723 decreased the glutathione levels in gastritis. The myeloperoxidase level in gastritis is increased, and its increment was decreased by CY3325 and CY3723. In reflux esophagitis, the ulceration was decreased by CY3325, CY3723. The gastric volume and acid output are reduced, whereas the pH value is increased by CY3325 or CY3723 after esophagitis. These results suggest that ceramide analogues, CY3325 and CY3723, can prevent the development of gastritis and reflux esophagitis in rats.
authors.affiliation: Department of Pharmacology, College of Pharmacy, Chung-Ang University, Seoul, 156-756, Republic of Korea.
authors.forename: Sung Hyo
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Pharmacology, College of Pharmacy, Chung-Ang University, Seoul, 156-756, Republic of Korea.
authors.forename: Seung In
authors.initials: SI
authors.lastname: Um
authors.affiliation: Department of Pharmacology, College of Pharmacy, Chung-Ang University, Seoul, 156-756, Republic of Korea.
authors.forename: Yoonjin
authors.initials: Y
authors.lastname: Nam
authors.affiliation: Department of Pharmacology, College of Pharmacy, Chung-Ang University, Seoul, 156-756, Republic of Korea.
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Park
authors.affiliation: Department of Pharmacology, College of Pharmacy, Catholic University of Daegu, Gyeongsan, 38430, Republic of Korea.
authors.forename: Je Hyun
authors.initials: JH
authors.lastname: Dong
authors.affiliation: Department of Oriental Medical Food & Nutrition, Semyung University, Jecheon, Choongbuk, 27136, Republic of Korea.
authors.forename: Sung Kwon
authors.initials: SK
authors.lastname: Ko
authors.affiliation: Department of Pharmacology, College of Pharmacy, Chung-Ang University, Seoul, 156-756, Republic of Korea. udsohn@cau.ac.kr.
authors.forename: Uy Dong
authors.identifier: http://orcid.org/0000-0002-1801-7551
authors.initials: UD
authors.lastname: Sohn
authors.affiliation: Department of Pharmacology, College of Pharmacy, Chung-Ang University, Seoul, 156-756, Republic of Korea. sjlee5029@cau.ac.kr.
authors.forename: Sang Joon
authors.initials: SJ
authors.lastname: Lee
mesh_terms: D000818:Animals; D002518:Ceramides / Q000737:chemistry* / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004941:Esophagitis / Q000188:drug therapy* / Q000473:pathology; D005756:Gastritis / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D016896:Treatment Outcome
chemical_list: D002518:Ceramides