title: Vitamin D level is associated with mortality predictors in ventilator-associated pneumonia caused by Acinetobacter baumannii.
abstract: BACKGROUND
  Vitamin D plays a role in host defense and is known to be associated with mortality in patients in the intensive care unit (ICU). We aimed to evaluate the relationships between vitamin D levels and predictors of mortality in patients with ventilator-associated pneumonia (VAP) caused by extensively drug-resistant Acinetobacter baumanii (XDR A. baumanii).
  
  
  METHODS
  A retrospective single-center study was conducted in an 18-bed adult ICU of a teaching hospital, including all patients with VAP due to XDR A. baumanii. Levels of 25(OH)D, procalcitonin (PCT), C-reactive protein (CRP), n-terminal pro-BNP (NT-proBNP), as well as clinical scores (Sequential Organ Failure Assessment [SOFA], Acute Physiology And Chronic Health Evaluation [APACHE II], Clinical Pulmonary Infection Score [CPIS) were recorded.
  
  
  RESULTS
  Forty-for patients were studied over six months. All patients had vitamin D deficiency. The 28-day mortality in patients with 25(OH)D levels ≤ 10 ng/mL was higher than in patients with 25(OH)D > 10ng/mL (p = 0.001). The fourth- and seventh-day SOFA scores (p= 0.04 and p= 0.001) and first- and fourth-day procalcitonin levels (p = 0.03 and p = 0.004) were higher in patients with 25(OH)D levels ≤ 10 ng/mL. The clinical scores (SOFA, CPIS, and CEPPIS) and biomarkers (NT-proBNP, PCT) were negatively correlated with 25(OH)D levels in all study groups.
  
  
  CONCLUSIONS
  Severe vitamin D deficiency was associated with adverse outcome in VAP due to XDR A. baumanii. Vitamin D levels may be a prognostic predictor of VAP. It is also important to evaluate the effect of rapid vitamin D replacement on mortality.
authors.affiliation: Marmara University School of Medicine, Istanbul, Turkey. mrt.haliloglu@gmail.com.
authors.forename: Murat
authors.initials: M
authors.lastname: Haliloglu
authors.forename: Beliz
authors.initials: B
authors.lastname: Bilgili
authors.forename: Ozlem
authors.initials: O
authors.lastname: Haliloglu
authors.forename: Dilek
authors.initials: D
authors.lastname: Gogas Yavuz
authors.forename: Ismail
authors.initials: I
authors.lastname: Cinel
mesh_terms: D000151:Acinetobacter Infections / Q000382:microbiology / Q000401:mortality* / Q000473:pathology*; D040981:Acinetobacter baumannii / Q000302:isolation & purification; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006784:Hospitals, Teaching; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D053717:Pneumonia, Ventilator-Associated / Q000382:microbiology / Q000401:mortality* / Q000473:pathology*; D011379:Prognosis; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016019:Survival Analysis; D014808:Vitamin D Deficiency / Q000150:complications*