title: The role of the neutrophil Fcγ receptor I (CD64) index in diagnosing spontaneous bacterial peritonitis in cirrhotic patients.
abstract: OBJECTIVE
  To investigate the role of the neutrophil Fcγ receptor I (CD64) index in the diagnosis of spontaneous bacterial peritonitis (SBP) in cirrhotic patients.
  
  
  METHODS
  A total of 123 cirrhotic patients with ascites who fulfilled the inclusion criteria were enrolled in this study. Ascites and blood samples were collected; the polymorphonuclear neutrophil (PMN) count, bacterial culture, and related laboratory tests were performed. The CD64 index was determined for each sample using flow cytometry.
  
  
  RESULTS
  The neutrophil CD64 index results were significantly higher in cirrhotic patients with SBP than in those without SBP (p<0.001). There was a positive correlation between the neutrophil CD64 index and the PMN count in ascites. In the receiver operating characteristic curve (ROC) analysis, the area under the curve (AUC) was 0.894 (95% confidence interval 0.823-0.964, p<0.001). The optimal cut-off value for the neutrophil CD64 index was 2.02. The sensitivity and specificity of the neutrophil CD64 index for cirrhotic patients with SBP were 80.49% and 93.90%, respectively. The elevated neutrophil CD64 index was down-regulated by antibiotic therapy (p=0.002).
  
  
  CONCLUSIONS
  The neutrophil CD64 index could be used as a sensitive and specific indicator for the diagnosis of SBP in cirrhotic patients with ascites and is also modulated by antibiotic therapy.
authors.affiliation: Department of Clinical Laboratory, Beijing You'an Hospital Affiliated to Capital Medical University, No. 8 You'an Men Wai Xi TouTiao, Fengtai District, Beijing 100069, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Dang
authors.affiliation: Department of Clinical Laboratory, Beijing You'an Hospital Affiliated to Capital Medical University, No. 8 You'an Men Wai Xi TouTiao, Fengtai District, Beijing 100069, China. Electronic address: loujinli@163.com.
authors.forename: Jinli
authors.initials: J
authors.lastname: Lou
authors.affiliation: Department of Clinical Laboratory, Beijing You'an Hospital Affiliated to Capital Medical University, No. 8 You'an Men Wai Xi TouTiao, Fengtai District, Beijing 100069, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yan
authors.affiliation: Department of Clinical Laboratory, Beijing You'an Hospital Affiliated to Capital Medical University, No. 8 You'an Men Wai Xi TouTiao, Fengtai District, Beijing 100069, China.
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Department of Clinical Laboratory, Beijing You'an Hospital Affiliated to Capital Medical University, No. 8 You'an Men Wai Xi TouTiao, Fengtai District, Beijing 100069, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Chen
authors.affiliation: Department of Clinical Laboratory, Beijing You'an Hospital Affiliated to Capital Medical University, No. 8 You'an Men Wai Xi TouTiao, Fengtai District, Beijing 100069, China.
authors.forename: Guizhen
authors.initials: G
authors.lastname: Sun
authors.affiliation: Centre of Infectious Diseases, Beijing You'an Hospital Affiliated to Capital Medical University, Beijing, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Li
mesh_terms: D001201:Ascites / Q000276:immunology; D001424:Bacterial Infections / Q000175:diagnosis* / Q000276:immunology; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008103:Liver Cirrhosis / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology*; D010538:Peritonitis / Q000175:diagnosis* / Q000276:immunology; D011446:Prospective Studies; D017452:Receptors, IgG / Q000097:blood*
chemical_list: D017452:Receptors, IgG
keywords: Ascites; Cirrhosis; Neutrophil CD64 index; Spontaneous bacterial peritonitis