title: The effect of statin treatment on the prevention of stent mediated flow limited edge dissections during PCI in patients with stable angina.
abstract: OBJECTIVE
  The effect of statin therapy before PCI with direct stenting may reduce the development of flow limited edge dissections (ED) in patients with stable angina.
  
  
  BACKGROUND
  Flow limited ED after PCI is associated with an increased risk of major adverse cardiovascular events. Statin therapy induces important changes in the plaque composition which have been previously identified as strong predictors of ED.
  
  
  METHODS
  100 patients complicated with flow limited ED and 100 control patients with successful procedure were enrolled into the study. EDs were described as the 5-mm regions that were immediately adjacent to the stent borders, both distally and proximally on the coronary angiography.
  
  
  RESULTS
  Rate of statin use and duration of statin use were significantly higher in patients with non-ED group (63%) versus ED group (25%) (p<0.001). In addition, patients in ED group had significantly higher levels of C-reactive protein (CRP) at admission (9.9mg/dL (5.89-16.45) vs. 4.40mg/dL (3.5-7.09), respectively, p=0.014).
  
  
  CONCLUSIONS
  Our findings suggested that maintenance statin treatment before PCI with direct stenting may reduce the development of flow limited ED in patients with stable angina.
authors.affiliation: Ankara Education and Research Hospital, Department of Cardiology, Ankara, Turkey. Electronic address: foksuz_42@hotmail.com.
authors.forename: Fatih
authors.initials: F
authors.lastname: Oksuz
authors.affiliation: Ankara Education and Research Hospital, Department of Cardiology, Ankara, Turkey.
authors.forename: Mikail
authors.initials: M
authors.lastname: Yarlioglues
authors.affiliation: Turkiye Yuksek Ihtisas Education and Research Hospital, Department of Cardiology, Ankara, Turkey.
authors.forename: Cagrı
authors.initials: C
authors.lastname: Yayla
authors.affiliation: Turkiye Yuksek Ihtisas Education and Research Hospital, Department of Cardiology, Ankara, Turkey.
authors.forename: Ugur
authors.initials: U
authors.lastname: Canpolat
authors.affiliation: Ankara Education and Research Hospital, Department of Cardiology, Ankara, Turkey.
authors.forename: Sani Namık
authors.initials: SN
authors.lastname: Murat
authors.affiliation: Turkiye Yuksek Ihtisas Education and Research Hospital, Department of Cardiology, Ankara, Turkey.
authors.forename: Sinan
authors.initials: S
authors.lastname: Aydogdu
mesh_terms: D000368:Aged; D060050:Angina, Stable / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000379:methods*; D012189:Retrospective Studies; D015607:Stents / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
keywords: Edge dissection; Stable angina pectoris; Statin therapy