title: Small cell lung cancer: Time to revisit DNA-damaging chemotherapy.
abstract: Rational use of DNA-damaging chemotherapy, with new combinations to heighten DNA replication stress, could improve outcomes in small cell lung cancer.
authors.affiliation: Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. anish.thomas@mail.nih.gov pommier@nih.gov.
authors.forename: Anish
authors.initials: A
authors.lastname: Thomas
authors.affiliation: Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. anish.thomas@mail.nih.gov pommier@nih.gov.
authors.forename: Yves
authors.initials: Y
authors.lastname: Pommier
mesh_terms: D000818:Animals; D004249:DNA Damage / Q000187:drug effects / Q000235:genetics*; D004261:DNA Replication / Q000187:drug effects / Q000235:genetics; D004358:Drug Therapy; D064420:Drug-Related Side Effects and Adverse Reactions; D042822:Genomic Instability / Q000187:drug effects / Q000235:genetics; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D055752:Small Cell Lung Carcinoma / Q000235:genetics*