title: [Clinical analysis of cutaneous manifestations and related factors in patients with ulcerative colitis].
abstract: OBJECTIVE
  To investigate the cutaneous manifestations in patients with ulcerative colitis (UC) and related factors.
  
  
  METHODS
  Patients admitted to Department of Gastroenterology Peking University First Hospital from January 1994 to December 2014 and diagnosed as UC were retrospectively enrolled in this study. Skin disorders were confirmed by the dermatologists. Clinical data were collected and compared between patients with and without cutaneous manifestations.
  
  
  RESULTS
  Among the total 373 UC patients, there were 34 cases (9.1%) with cutaneous manifestations, including 11 pyoderma gangrenosum, 8 erythema nodosum, 6 eczema, 3 psoriasis, 2 pemphigus, 1 granulomatous cheilitis, 1 ichthyosis, 1 acne rosacea, and 1 impetigo. The skin manifestations may occur after the diagnosis, simultaneously or even before the diagnosis of UC, which were 24, 7 and 3 patients respectively. The mean age in patients with skin lesions was (47.2±12.1) years, male to female ratio 0.79∶1. More patients with skin manifestations had severe activity of UC compared with non-skin group [50.0%(17/34) vs 25.1%(85/339), P=0.01]. In addition, the proportion of extensive colitis in skin lesion group was significantly higher than that in non-skin group [76.5%(26/34) vs 54.6%(185/339), P=0.04].
  
  
  CONCLUSIONS
  The cutaneous manifestations associated with UC are polymorphic, erythema nodosums and pyoderma gangrenosums are the most common skin lesions seen in UC patients. Skin lesions occur concurrently, pre or post the diagnosis of UC. Skin lesions in UC patients suggest more severe disease activity. Clinicians need to pay more attention to this group.
authors.affiliation: Department of Gastroenterology, Peking University First Hospital, Beijing 100034, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Tian
authors.forename: J X
authors.initials: JX
authors.lastname: Li
authors.forename: H H
authors.initials: HH
authors.lastname: Wang
authors.forename: R Y
authors.initials: RY
authors.lastname: Li
authors.forename: X G
authors.initials: XG
authors.lastname: Liu
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D003093:Colitis, Ulcerative / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D003424:Crohn Disease / Q000175:diagnosis* / Q000453:epidemiology; D004893:Erythema Nodosum / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000175:diagnosis / Q000453:epidemiology*; D017511:Pyoderma Gangrenosum / Q000175:diagnosis / Q000453:epidemiology*; D012189:Retrospective Studies; D012871:Skin Diseases / Q000175:diagnosis / Q000453:epidemiology*