title: [Grading of gynecological tumors : Current aspects].
abstract: Histopathological assessment of the tumor grade and cell type is central to the management and prognosis of various gynecological malignancies. Conventional grading systems for squamous carcinomas and adenocarcinomas of the vulva, vagina and cervix are poorly defined. For endometrioid tumors of the female genital tract as well as for mucinous endometrial, ovarian and seromucinous ovarian carcinomas, the 3‑tiered FIGO grading system is recommended. For uterine neuroendocrine tumors the grading system of the gastrointestinal counterparts has been adopted. Uterine leiomyosarcomas are not graded. Endometrial stromal sarcomas are divided into low and high grades, based on cellular morphology, immunohistochemical and molecular findings. A chemotherapy response score was established for chemotherapeutically treated high-grade serous pelvic cancer. For non-epithelial ovarian malignancies, only Sertoli-Leydig cell tumors and immature teratomas are graded. At this time molecular profiling has no impact on the grading of tumors of the female genital tract.
authors.affiliation: Institut für Pathologie, Abteilung Mamma-, Gynäko- & Perinatalpathologie, Universitätsklinikum Leipzig AöR, Liebigstraße 26, 04103, Leipzig, Deutschland. hornl@medizin.uni-leipzig.de.
authors.forename: L-C
authors.initials: LC
authors.lastname: Horn
authors.affiliation: Pathologisches Institut, Ludwig-Maximilins-Universität, München, Deutschland.
authors.forename: D
authors.initials: D
authors.lastname: Mayr
authors.affiliation: Frauenklinik des Klinikums rechts der Isar, Technischen Universität München, München, Deutschland.
authors.forename: C E
authors.initials: CE
authors.lastname: Brambs
authors.affiliation: Universitätsfrauenklinik Leipzig (Triersches Institut) im Zentrum für Frauen- und Kindermedizin, Universitätsklinikum Leipzig AöR, Leipzig, Deutschland.
authors.forename: J
authors.initials: J
authors.lastname: Einenkel
authors.affiliation: Institut für Pathologie, Abteilung Mamma-, Gynäko- & Perinatalpathologie, Universitätsklinikum Leipzig AöR, Liebigstraße 26, 04103, Leipzig, Deutschland.
authors.forename: I
authors.initials: I
authors.lastname: Sändig
authors.affiliation: Institut für Pathologie, Abteilung Mamma-, Gynäko- & Perinatalpathologie, Universitätsklinikum Leipzig AöR, Liebigstraße 26, 04103, Leipzig, Deutschland.
authors.forename: K
authors.initials: K
authors.lastname: Schierle
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D016889:Endometrial Neoplasms / Q000473:pathology; D005260:Female; D005833:Genital Neoplasms, Female / Q000145:classification / Q000473:pathology*; D005836:Genitalia, Female / Q000473:pathology; D006801:Humans; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D018358:Neuroendocrine Tumors / Q000473:pathology; D010051:Ovarian Neoplasms / Q000473:pathology; D011379:Prognosis; D018310:Sertoli-Leydig Cell Tumor / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000473:pathology; D014625:Vaginal Neoplasms / Q000473:pathology; D014846:Vulvar Neoplasms / Q000473:pathology
keywords: Endometrial cancer; Molecular pathology; Neuroendocrine malignancies; Ovarian cancer; Sertoli Leydig cell tumor