title: Structural Features and Potent Antidepressant Effects of Total Sterols and β-sitosterol Extracted from Sargassum horneri.
abstract: The purified total sterols and β-sitosterol extracted from Sargassum horneri were evaluated for their antidepressant-like activity using the forced swim test (FST) and tail suspension test (TST) in mice. Total sterols and β-sitosterol significantly reduced the immobility time in the FST and TST. Total sterols were administered orally for 7 days at doses of 50, 100, and 200 mg/kg, and β-sitosterol was administered intraperitoneally at doses of 10, 20, and 30 mg/kg. β-sitosterol had no effect on locomotor activity in the open field test. In addition, total sterols and β-sitosterol significantly increased NE, 5-HT, and the metabolite 5-HIAA in the mouse brain, suggesting that the antidepressant-like activity may be mediated through these neurotransmitters.
authors.affiliation: The Basic Medical College, Jilin Medical University, Jilin 132013, China. zdh1027@sina.com.
authors.forename: Donghai
authors.initials: D
authors.lastname: Zhao
authors.affiliation: The Second Hospital, Jilin University, Changchun 130041, China. davezheng@sohu.com.
authors.forename: Lianwen
authors.initials: L
authors.lastname: Zheng
authors.affiliation: The Basic Medical College, Jilin Medical University, Jilin 132013, China. qiling1718@163.com.
authors.forename: Ling
authors.initials: L
authors.lastname: Qi
authors.affiliation: The Basic Medical College, Jilin Medical University, Jilin 132013, China. shuranwang@163.com.
authors.forename: Shuran
authors.initials: S
authors.lastname: Wang
authors.affiliation: Food and Pharmacy College, Zhejiang Ocean University, Zhoushan 316022, China. glp730@163.com.
authors.forename: Liping
authors.initials: L
authors.lastname: Guan
authors.affiliation: Food and Pharmacy College, Zhejiang Ocean University, Zhoushan 316022, China. 18368081369@163.com.
authors.forename: Yanan
authors.initials: Y
authors.lastname: Xia
authors.affiliation: The Basic Medical College, Jilin Medical University, Jilin 132013, China. caijianhui_jl@sina.com.
authors.forename: Jianhui
authors.initials: J
authors.lastname: Cai
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000737:chemistry* / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003863:Depression / Q000188:drug therapy; D019417:Hindlimb Suspension / Q000379:methods; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects; D018377:Neurotransmitter Agents / Q000378:metabolism; D044647:Sargassum / Q000737:chemistry*; D012701:Serotonin / Q000378:metabolism; D012855:Sitosterols / Q000737:chemistry* / Q000494:pharmacology*; D013261:Sterols / Q000737:chemistry* / Q000494:pharmacology*; D013550:Swimming / Q000502:physiology
chemical_list: D000928:Antidepressive Agents; D018377:Neurotransmitter Agents; D012855:Sitosterols; D013261:Sterols; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; C025473:gamma-sitosterol
keywords: FST; Sargassum horneri; TST; monoamine neurotransmitters; sterols; β-sitosterol