title: Hemodynamic Functions of Fenestrated Stent Graft under Resting, Hypertension, and Exercise Conditions.
abstract: The aim of this study was to assess the hemodynamic performance of a patient-specific fenestrated stent graft (FSG) under different physiological conditions, including normal resting, hypertension, and hypertension with moderate lower limb exercise. A patient-specific FSG model was constructed from computed tomography images and was discretized into a fine unstructured mesh comprising tetrahedral and prism elements. Blood flow was simulated using Navier-Stokes equations, and physiologically realistic boundary conditions were utilized to yield clinically relevant results. For a given cycle-averaged inflow of 2.08 L/min at normal resting and hypertension conditions, approximately 25% of flow was channeled into each renal artery. When hypertension was combined with exercise, the cycle-averaged inflow increased to 6.39 L/min but only 6.29% of this was channeled into each renal artery, which led to a 438.46% increase in the iliac flow. For all the simulated scenarios and throughout the cardiac cycle, the instantaneous flow streamlines in the FSG were well organized without any notable flow recirculation. This well-organized flow led to low values of endothelial cell activation potential, which is a hemodynamic metric used to identify regions at risk of thrombosis. The displacement forces acting on the FSG varied with the physiological conditions, and the cycle-averaged displacement force at normal rest, hypertension, and hypertension with exercise was 6.46, 8.77, and 8.99 N, respectively. The numerical results from this study suggest that the analyzed FSG can maintain sufficient blood perfusion to the end organs at all the simulated conditions. Even though the FSG was found to have a low risk of thrombosis at rest and hypertension, this risk can be reduced even further with moderate lower limb exercise.
authors.affiliation: Department of Chemical Engineering, Imperial College London , London , UK.
authors.forename: Harkamaljot Singh
authors.initials: HS
authors.lastname: Kandail
authors.affiliation: Department of Interventional Radiology, St Mary's Hospital, Imperial College Healthcare NHS Trust , London , UK.
authors.forename: Mohamad
authors.initials: M
authors.lastname: Hamady
authors.affiliation: Department of Chemical Engineering, Imperial College London , London , UK.
authors.forename: Xiao Yun
authors.initials: XY
authors.lastname: Xu
keywords: computational fluid dynamics; endovascular aneurysm repair; exercise; fenestrated stent graft; hemodynamics; hypertension; rest