title: Treatment of a Recurrent Neuroma Within Nerve Allograft With Autologous Nerve Reconstruction.
abstract: BACKGROUND
  The purpose of this case report is to describe the findings of a neuroma within an allograft, highlight the unique opportunity to evaluate the allograft (following human engraftment) ex vivo histologically, to reinforce an effective treatment strategy, and review outcomes in peripheral nerve surgery regarding gap defect distance.
  
  
  METHODS
  A 55-year-old, right hand dominant man suffered a workplace injury 37 years ago resulting in lacerations and crush injury of the palm and lacerations of the left index finger requiring multiple neuroma excisions and eventual ray amputation. In an attempt to address stump neuroma pain and restore sensation of the radial digital nerve of the middle finger, which was lost after the ray amputation, a neuroma was resected and reconstructed with a 45-mm bioabsorbable allograft (AxoGen, Inc, Alachua, Florida). After the inciting injury in 1977, the patient initially presented to our clinic in 2013 with return of pain at the palm and numbness along the distribution of the common digital nerve and radial nerve of the middle finger prompting surgical exploration. A recurrent common digital nerve neuroma was identified at the proximal aspect of the allograft measuring 20 mm and was resected along with the remaining allograft.
  
  
  RESULTS
  A 50-mm reversed superficial peroneal interpositional nerve graft was used for reconstruction resulting in progressive resolution of pain. On 6-month follow-up, the patient regained indiscriminate sensation with moving 2-point discrimination at the pulp of the middle finger with improved grasp function.
  
  
  CONCLUSIONS
  In the setting of recalcitrant neuromas and intractable pain following multiple neuroma excisions, allografts may be suboptimal in reconstruction of larger gap defects. Autologous reconstruction with porcine submucosa extracellular matrix, as in this case, can avoid tethering, local ischemia, and nerve traction to optimize outcomes.
authors.affiliation: R Adams Cowley Shock Trauma Center, Baltimore, MD, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Sosin
authors.affiliation: Georgetown University School of Medicine, Washington, DC, USA.
authors.forename: Lindsay A
authors.initials: LA
authors.lastname: Weiner
authors.affiliation: University of Maryland-Upper Chesapeake Health, Bel Air, MD, USA.
authors.forename: Bradley C
authors.initials: BC
authors.lastname: Robertson
authors.affiliation: R Adams Cowley Shock Trauma Center, Baltimore, MD, USA; University of Maryland-Upper Chesapeake Health, Bel Air, MD, USA; Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Ramon A
authors.initials: RA
authors.lastname: DeJesus
keywords: Axogen; common digital nerve; nerve; neuroma; sural