title: [A multicenter study on the prognostic factors of one year outcomes in patients with poor grade intracranial aneurysm after early treatment].
abstract: OBJECTIVE
  To explore the one year outcome of subarachnoid hemorrhage (SAH) patients with poor grade intracranial aneurysm who underwent early treatment (within 72 hours), and to analyze the possible predictors of the prognosis.
  
  
  METHODS
  This clinical study was a prospective, multicenter, observational registry of SAH patients with poor grade intracranial aneurysm. Data pertaining to 203 SAH patients with poor grade intracranial aneurysm between October 2010 and March 2013 from 10 medical centers. There were 100 male and 103 female patients. Neurological outcomes at 12 months after the surgery were measured using the Glasgow Outcome Scale (GOS). Genders, age, smoke, breath, herniation, aneurysm location, World Federation of Neurosurgical Societies (WFNS) grade, CT Fisher's grade, alcohol consumption, aneurysm diameter, surgical procedure and operation time were identified as possible prognostic factors, the association between possible prognostic factors and outcome were analyzed, using univariate and multivariate analysis. Univariate analysis included Wilcoxon rank sum test, Kruskal-Wallis H test and Nemenyi test, multivariate analysis included Logistic regression test.
  
  
  RESULTS
  Among 203 patients, 94 patients were WFNS grade Ⅳ, and 109 patients were WFNS grade Ⅴ; 31 patients were CT Fisher's grade 1 to 2, 172 patients were CT Fisher's grade 3 to 5. Herniation (OR=2.535, 95%CI: 1.204 to 5.339, P=0.014), WFNS grade Ⅴ (OR=3.728, 95%CI: 1.972 to 7.043, P=0.000), CT Fisher's grade 3 to 5 (OR=5.641, 95%CI: 2.032 to 15.643, P=0.001), and anterior circulation location (OR=6.234, 95%CI: 1.996 to 19.472, P=0.002) were found to be independent prognostic factors of unfavorable prognosis.
  
  
  CONCLUSIONS
  Early surgical treatment could improve the prognosis of SAH patients with poor-grade-aneurysm. The patients with herniation, WFNS grade Ⅴ, CT Fisher's grade 3 to 5, anterior circulation aneurysms suffered unfavorable prognosis.
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital, Wenzhou Medical University, Wenzhou 325000, China.
authors.forename: K
authors.initials: K
authors.lastname: Zheng
authors.forename: Z F
authors.initials: ZF
authors.lastname: Tian
authors.forename: X X
authors.initials: XX
authors.lastname: Tan
authors.forename: Z Q
authors.initials: ZQ
authors.lastname: Li
authors.forename: Y
authors.initials: Y
authors.lastname: Xiong
authors.forename: B
authors.initials: B
authors.lastname: Zhao
authors.forename: L
authors.initials: L
authors.lastname: Pan
authors.forename: M
authors.initials: M
authors.lastname: Zhong
authors.forename: H Z
authors.initials: HZ
authors.lastname: Shi
authors.forename: C S
authors.initials: CS
authors.lastname: Liang
authors.forename: H Q
authors.initials: HQ
authors.lastname: Zhang
authors.forename: Z W
authors.initials: ZW
authors.lastname: Zhao
authors.forename: Z G
authors.initials: ZG
authors.lastname: Wang
authors.forename: H D
authors.initials: HD
authors.lastname: Wang
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: H
authors.initials: H
authors.lastname: Yang
authors.forename: G
authors.initials: G
authors.lastname: Zhu
mesh_terms: D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm; D008297:Male; D015999:Multivariate Analysis; D011379:Prognosis; D011446:Prospective Studies; D013345:Subarachnoid Hemorrhage