title: Evaluation of the Clinical Significance of Serum Carcinoembryonic Antigen in Patients with Resectable Gastric Adenocarcinoma.
abstract: Carcinoembryonic antigen (CEA) is the most commonly used tumor marker for gastrointestinal cancers but its value for resectable gastric adenocarcinoma (RGA) patients in areas of high GA incidence is uncertain.
  
  
  
  We retrospectively studied 400 subjects with RGA from the Fujian Province in China, which has a high incidence of GA. Patients had surgery between January 2010 and December 2013. CEA was measured and correlated to pathology.
  
  
  
  High pretreatment serum CEA (>5 ng/mL) was associated with patient age (p = 0.000), tumor size (p = 0.008), and T and N stages (p = 0.002, p = 0.032, respectively), alpha fetoprotein (p = 0.014), and CA19-9 (p = 0.000). High CEA was significantly associated with poor overall survival. Overall survival in the whole group of patients was 63.8%, whereas it was only 42.9% in the high CEA group (p = 0.0001). Mean overall survival for high CEA patients was significantly shorter than patients with low CEA (36.5 ± 2.63 months vs. 47.4 ± 0.98 months, p = 0.000). Multivariate analysis confirmed that pretreatment serum CEA was an independent prognostic factor for increased death risk. Additionally, mean CEA in 45 high CEA patients was reduced after surgery.
  
  
  
  Pretreatment serum CEA may help to predict survival for patients with RGA in high GA incidence areas.
authors.affiliation: Department of Experimental Medicine, Fuzhou General Hospital (Dongfang Hospital), Fuzhou City, Fujian Province 350025, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Dang
authors.affiliation: Department of Experimental Medicine, Fuzhou General Hospital (Dongfang Hospital), Fuzhou City, Fujian Province 350025, China.
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Ouyang
authors.affiliation: Department of Experimental Medicine, Fuzhou General Hospital (Dongfang Hospital), Fuzhou City, Fujian Province 350025, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Wang
authors.affiliation: Department of Experimental Medicine, Fuzhou General Hospital (Dongfang Hospital), Fuzhou City, Fujian Province 350025, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Department of Experimental Medicine, Fuzhou General Hospital (Dongfang Hospital), Fuzhou City, Fujian Province 350025, China. Electronic address: huangqj100@126.com.
authors.forename: Qiaojia
authors.initials: Q
authors.lastname: Huang
mesh_terms: D000230:Adenocarcinoma / Q000097:blood* / Q000175:diagnosis / Q000401:mortality; D000368:Aged; D018395:CA-19-9 Antigen / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000097:blood*; D002681:China; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000401:mortality; D015996:Survival Rate; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen; D000509:alpha-Fetoproteins
keywords: Carcinoembryonic antigen; Clinicopathological features; Overall survival; Resectable gastric adenocarcinoma