title: Controlled release of curcumin from curcumin-loaded nanomicelles to prevent peritendinous adhesion during Achilles tendon healing in rats.
abstract: We introduced curcumin-loaded nanomicelles into a tendon-healing model to evaluate their effects on tendon healing and adhesion. Three groups consisting of 36 rats underwent rupture and repair of the Achilles tendon. The treatment group received an injection of curcumin-loaded nanomicelles (gold nanorods [GNRs]-1/curcumin in polymeric nanomicelles [curc@PMs] at a dosage of 0.44 mg curcumin/kg in 0.1 mL saline) into the surgical site and exposed to laser postoperatively at weeks 1, 2, and 3, for three times 10 seconds each, on the surgical site in the rats that underwent tendon rupture and repair, while the other two groups received 0.44 mg curcumin/kg in 0.1 mL saline and 0.1 mL of saline, respectively. The specimens were harvested at 4 weeks and subjected to biomechanical and histological evaluation. The scoring results of tendon adhesion indicated that GNRs-1/curc@PMs group was in the lowest grade of peritendinous adhesions compared to the other groups. Histological assessment further confirmed the preventive effect of GNRs-1/curc@PMs on tendon adhesion. These findings indicated greater tendon strength with less adhesion in the group treated with GNRs-1/curc@PMs combined with laser exposure, and that nanoparticle-based therapy may be applied to prevent adhesion in clinical patients.
authors.affiliation: Department of Hand Surgery, China-Japan Union Hospital, Jilin University, Changchun, People's Republic of China.
authors.forename: Weizhong
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Division of Surgical Oncology, Department of Surgery, University of Louisville School of Medicine, Louisville, KY, USA.
authors.forename: Xuanyi
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Industrial Chemistry "Toso Montanari", University of Bologna, Bologna, Italy.
authors.forename: Mauro
authors.initials: M
authors.lastname: Comes Franchini
authors.affiliation: Department of Hand Surgery, China-Japan Union Hospital, Jilin University, Changchun, People's Republic of China.
authors.forename: Ke
authors.initials: K
authors.lastname: Xu
authors.affiliation: Department of Industrial Chemistry "Toso Montanari", University of Bologna, Bologna, Italy.
authors.forename: Erica
authors.initials: E
authors.lastname: Locatelli
authors.affiliation: Division of Surgical Oncology, Department of Surgery, University of Louisville School of Medicine, Louisville, KY, USA.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Martin
authors.affiliation: Department of Industrial Chemistry "Toso Montanari", University of Bologna, Bologna, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Monaco
authors.affiliation: Division of Surgical Oncology, Department of Surgery, University of Louisville School of Medicine, Louisville, KY, USA.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Hand Surgery, China-Japan Union Hospital, Jilin University, Changchun, People's Republic of China.
authors.forename: Shusen
authors.initials: S
authors.lastname: Cui
mesh_terms: D000125:Achilles Tendon / Q000187:drug effects* / Q000293:injuries / Q000502:physiology; D000818:Animals; D003474:Curcumin / Q000008:administration & dosage* / Q000494:pharmacology; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000494:pharmacology*; D004195:Disease Models, Animal; D008297:Male; D008823:Micelles; D043942:Nanotubes; D011108:Polymers / Q000494:pharmacology; D017207:Rats, Sprague-Dawley; D012421:Rupture / Q000188:drug therapy / Q000601:surgery; D013708:Tendon Injuries / Q000188:drug therapy / Q000473:pathology; D000267:Tissue Adhesions / Q000473:pathology / Q000517:prevention & control*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D003692:Delayed-Action Preparations; D008823:Micelles; D011108:Polymers; D003474:Curcumin
keywords: curcumin; nanorods; peritendinous adhesion