title: Host and Toxoplasma gondii genetic and non-genetic factors influencing the development of ocular toxoplasmosis: A systematic review.
abstract: Toxoplasmosis is a cosmopolitan infection caused by the apicomplexan parasite Toxoplasma gondii. This infectious disease is widely distributed across the world where cats play an important role in its spread. The symptomatology caused by this parasite is diverse but the ocular affectation emerges as the most important clinical phenotype. Therefore, we conducted a systematic review of the current knowledge of ocular toxoplasmosis from the genetic diversity of the pathogen towards the treatment available for this infection. This review represents an update to the scientific community regarding the genetic diversity of the parasite, the genetic factors of the host, the molecular pathogenesis and its association with disease, the available diagnostic tools and the available treatment of patients undergoing ocular toxoplamosis. This review will be an update for the scientific community in order to encourage researchers to deploy cutting-edge investigation across this field.
authors.affiliation: Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia; Grupo de Investigaciones Microbiológicas - UR (GIMUR), Programa de Biología, Facultad de Ciencias Naturales y Matemáticas, Universidad del Rosario, Bogotá, Colombia.
authors.forename: Carolina
authors.initials: C
authors.lastname: Fernández
authors.affiliation: Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia; Grupo de Investigaciones Microbiológicas - UR (GIMUR), Programa de Biología, Facultad de Ciencias Naturales y Matemáticas, Universidad del Rosario, Bogotá, Colombia.
authors.forename: Jesús
authors.initials: J
authors.lastname: Jaimes
authors.affiliation: Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia; Grupo de Investigaciones Microbiológicas - UR (GIMUR), Programa de Biología, Facultad de Ciencias Naturales y Matemáticas, Universidad del Rosario, Bogotá, Colombia.
authors.forename: María Camila
authors.initials: MC
authors.lastname: Ortiz
authors.affiliation: Grupo de Investigaciones Microbiológicas - UR (GIMUR), Programa de Biología, Facultad de Ciencias Naturales y Matemáticas, Universidad del Rosario, Bogotá, Colombia. Electronic address: juand.ramirez@urosario.edu.co.
authors.forename: Juan David
authors.initials: JD
authors.lastname: Ramírez
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents / Q000494:pharmacology / Q000627:therapeutic use; D020022:Genetic Predisposition to Disease; D006790:Host-Parasite Interactions; D006801:Humans; D007111:Immunity, Cellular; D056724:Immunity, Humoral; D014122:Toxoplasma / Q000235:genetics* / Q000276:immunology; D014126:Toxoplasmosis, Ocular / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology / Q000469:parasitology
chemical_list: D000977:Antiparasitic Agents
keywords: Eye; Infectious diseases; Toxoplasma gondii; Toxoplasmosis