title: Association of IL-10 (-819T/C, -592A/C and -1082A/G) and IL-6 -174G/C gene polymorphism and the risk of pneumonia-induced sepsis.
abstract: BACKGROUND
  Association between inherited variants and the risks of sepsis is controversial.
  
  
  OBJECTIVE
  To evaluate the risk of pneumonia-induced sepsis by examining its linkage with polymorphisms of IL-6 and IL-10.
  
  
  METHODS
  Samples were obtained from 188 pneumonia-induced sepsis patients, 162 pneumonia patients and 200 healthy controls.
  
  
  RESULTS
  Subjects with IL-10 -1082 AA genotypes and IL-6 -174 CC genotype had a higher risk of sepsis and increased mRNA levels.
  
  
  CONCLUSIONS
  The variants of IL-10 -1082 A allele and IL-6 -174 C allele contributed to an increased risk of pneumonia-induced sepsis.
authors.affiliation: a Department of Intensive Care Unit , The First Affiliated Hospital of Henan University of Traditional Chinese Medicine , Zhengzhou , China.
authors.forename: Zheng-Rong
authors.initials: ZR
authors.lastname: Mao
authors.affiliation: a Department of Intensive Care Unit , The First Affiliated Hospital of Henan University of Traditional Chinese Medicine , Zhengzhou , China.
authors.forename: Shao-Lei
authors.initials: SL
authors.lastname: Zhang
authors.affiliation: a Department of Intensive Care Unit , The First Affiliated Hospital of Henan University of Traditional Chinese Medicine , Zhengzhou , China.
authors.forename: Bo
authors.initials: B
authors.lastname: Feng
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D015850:Interleukin-6 / Q000235:genetics*; D008875:Middle Aged; D011014:Pneumonia / Q000150:complications*; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D018805:Sepsis / Q000209:etiology* / Q000235:genetics
chemical_list: C508609:IL10 protein, human; C508600:IL6 protein, human; D015850:Interleukin-6; D016753:Interleukin-10
keywords: IL-10; IL-6; Single-nuclear polymorphism; inflammation; mRNA; sepsis