title: The hemodynamic effects of the LVAD outflow cannula location on the thrombi distribution in the aorta: A primary numerical study.
abstract: Although a growing number of patients undergo LVAD implantation for heart failure treatment, thrombi are still the devastating complication for patients who used LVAD. LVAD outflow cannula location and thrombi generation sources were hypothesized to affect the thrombi distribution in the aorta. To test this hypothesis, numerical studies were conducted by using computational fluid dynamic (CFD) theory. Two anastomotic configurations, in which the LVAD outflow cannula is anastomosed to the anterior and lateral ascending aortic wall (named as anterior configurations and lateral configurations, respectively), are designed. The particles, whose sized are same as those of thrombi, are released at the LVAD output cannula and the aortic valve (named as thrombiP and thrombiL, respectively) to calculate the distribution of thrombi. The simulation results demonstrate that the thrombi distribution in the aorta is significantly affected by the LVAD outflow cannula location. In anterior configuration, the thrombi probability of entering into the three branches is 23.60%, while that in lateral configuration is 36.68%. Similarly, in anterior configuration, the thrombi probabilities of entering into brachiocephalic artery, left common carotid artery and left subclavian artery, is 8.51%, 9.64%, 5.45%, respectively, while that in lateral configuration it is 11.39%, 3.09%, 22.20% respectively. Moreover, the origins of thrombi could affect their distributions in the aorta. In anterior configuration, the thrombiP has a lower probability to enter into the three branches than thrombiL (12% vs. 25%). In contrast, in lateral configuration, the thrombiP has a higher probability to enter into the three branches than thrombiL (47% vs. 35%). In brief, the LVAD outflow cannula location significantly affects the distribution of thrombi in the aorta. Thus, in the clinical practice, the selection of outflow location of LVAD and the risk of thrombi formed in the left ventricle should be paid more attention than before.
authors.affiliation: School of Life Science and BioEngineering, Beijing University of Technology, Beijing 100124, China.
authors.forename: Yage
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: School of Life Science and BioEngineering, Beijing University of Technology, Beijing 100124, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Gao
authors.affiliation: School of Life Science and BioEngineering, Beijing University of Technology, Beijing 100124, China. Electronic address: changyu@bjut.edu.cn.
authors.forename: Chang
authors.initials: C
authors.lastname: Yu
mesh_terms: D006352:Heart Ventricles / Q000503:physiopathology*; D006353:Heart-Assist Devices; D006439:Hemodynamics; D006801:Humans; D008962:Models, Theoretical; D020521:Stroke / Q000209:etiology; D013927:Thrombosis / Q000150:complications / Q000503:physiopathology*
keywords: CFD; Heart failure; LVAD; Stroke; Thrombi distribution