title: Reduced Expression of FADS1 Predicts Worse Prognosis in Non-Small-Cell Lung Cancer.
abstract: OBJECTIVE
  Fatty acid desaturase 1 is a member of the fatty acid desaturase, which is related to a number of diseases. However, its role in cancers remains unclear. This study was to explore the clinical importance of FADS1 expression in non-small-cell lung cancer (NSCLC).
  
  
  METHODS
  Immunochemistry was used to evaluate FADS1 expressions in 216 paraffin-embedded specimens. The expression of FADS1 was divided into high and low groups. The clinical and prognostic significance of FADS1 expression was analyzed statistically by Kaplan-Meier estimate and Cox regression model.
  
  
  RESULTS
  FADS1 overexpressed in normal bronchial mucosa compared with non-small-cell lung cancer. Reduced FADS1 expression was associated with tumor size (P=0.023) and histological grade (P<0.0001). Patients with lower expression of FADS1 had shorter overall survival and disease free survival (P=0.001 and P=0.002). Multivariate analysis showed FADS1 expression was an independent prognostic factor in NSCLC (P=0.011).
  
  
  CONCLUSIONS
  Reduced expression of FADS1 suggests pessimistic prognosis for NSCLC patients. Further studies are warranted.
authors.affiliation: 1. Department of Thoracic Surgery, Affiliated Hospital of Qingdao University, Qingdao 266000, P.R. China;
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
authors.affiliation: 2. Department of First Chemotherapy, Affiliated Cancer Hospital of Guangxi Medical University, 71 Hedi Road, Nanning 530021, P. R. China;
authors.forename: Yan
authors.initials: Y
authors.lastname: Lin
authors.affiliation: 3. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, P. R. China;
authors.forename: Bei
authors.initials: B
authors.lastname: Gao
authors.affiliation: 4. State Key Laboratory of Oncology in South China; Department of Pathology, Sun Yat-Sen University Cancer Center; Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P.R. China;
authors.forename: Shumei
authors.initials: S
authors.lastname: Yan
authors.affiliation: 5. University of Illinois at Chicago, Biological Science, Chicago, Illinois 60607, USA.
authors.forename: Huini
authors.initials: H
authors.lastname: Wu
authors.affiliation: 4. State Key Laboratory of Oncology in South China; Department of Pathology, Sun Yat-Sen University Cancer Center; Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P.R. China;
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
authors.affiliation: 4. State Key Laboratory of Oncology in South China; Department of Pathology, Sun Yat-Sen University Cancer Center; Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P.R. China;
authors.forename: Qiuliang
authors.initials: Q
authors.lastname: Wu
authors.affiliation: 1. Department of Thoracic Surgery, Affiliated Hospital of Qingdao University, Qingdao 266000, P.R. China;
authors.forename: Yucheng
authors.initials: Y
authors.lastname: Wei
keywords: Fatty acid desaturase 1 (FADS1); immunohistochemistry (IHC).; non-small-cell lung cancer (NSCLC)