title: Gaseous and Particulate Content of Laser Hair Removal Plume.
abstract: Potentially harmful chemicals are released when tissues are vaporized. Laser hair removal (LHR) causes heating and often vaporization of hairs, producing both a signature malodorous plume and visible particulates.
  
  
  
  To characterize the chemical composition and quantify the ultrafine particle content of the plume generated during LHR.
  
  
  
  In the laser center of a large academic hospital, discarded terminal hairs from the trunk and extremities were collected from 2 adult volunteers. The hair samples were sealed in glass gas chromatography chambers and treated with a laser. The laser plume was analyzed by gas chromatography-mass spectrometry (GC-MS). During LHR treatment, two 6-L negative pressure canisters were used to capture 30 seconds of laser plume, and a portable condensation particle counter was used to measure ultrafine particulates (<1 µm). Ultrafine particle concentrations were measured within the treatment room, within the waiting room, and outside the building.
  
  
  
  The chemical content of the laser plume was analyzed with GC-MS and screened for aerosolized toxins using Environmental Protection Agency-certified methods. The ambient concentration of ultrafine particles during LHR was measured by condensation particle counters.
  
  
  
  Analysis with GC-MS identified 377 chemical compounds. Sixty-two of these compounds, of which 13 are known or suspected carcinogens and more than 20 are known environmental toxins, exhibited strong absorption peaks. During LHR, the portable condensation particle counters documented an 8-fold increase compared with the ambient room baseline level of ultrafine particle concentrations (ambient room baseline, 15 300 particles per cubic centimeter [ppc]; LHR with smoke evacuator, 129 376 ppc), even when a smoke evacuator was in close proximity (5.0 cm) to the procedure site. When the smoke evacuator was turned off for 30 seconds, there was a more than 26-fold increase in particulate count compared with ambient baseline levels (ambient baseline, 15 300 ppc; LHR without smoke evacuator for 30 seconds, 435 888 ppc).
  
  
  
  These findings establish the concern that the burning-hair plume often present during LHR should be considered a biohazard, warranting the use of smoke evacuators, good ventilation, and respiratory protection, especially for health care workers with prolonged exposure to LHR plume.
authors.affiliation: Wellman Center for Photomedicine, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston2Division of Dermatology, David Geffen School of Medicine, University of California, Los Angeles.
authors.forename: Gary S
authors.initials: GS
authors.lastname: Chuang
authors.affiliation: Wellman Center for Photomedicine, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston.
authors.forename: William
authors.initials: W
authors.lastname: Farinelli
authors.affiliation: Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston4Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts.
authors.forename: David C
authors.initials: DC
authors.lastname: Christiani
authors.affiliation: Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts.
authors.forename: Robert F
authors.initials: RF
authors.lastname: Herrick
authors.affiliation: Chemical Instrumentation Center, Department of Chemistry, Boston University, Boston, Massachusetts.
authors.forename: Norman C Y
authors.initials: NC
authors.lastname: Lee
authors.affiliation: Wellman Center for Photomedicine, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston.
authors.forename: Mathew M
authors.initials: MM
authors.lastname: Avram
mesh_terms: D000336:Aerosols / Q000032:analysis / Q000737:chemistry; D004781:Environmental Exposure / Q000032:analysis; D004784:Environmental Monitoring / Q000379:methods; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D005740:Gases / Q000032:analysis / Q000737:chemistry*; D006204:Hair Removal / Q000379:methods*; D006801:Humans; D053685:Laser Therapy / Q000009:adverse effects* / Q000379:methods; D052638:Particulate Matter / Q000032:analysis / Q000737:chemistry*
chemical_list: D000336:Aerosols; D005740:Gases; D052638:Particulate Matter