title: Patterns of postictal cerebral perfusion in idiopathic generalized epilepsy: a multi-delay multi-parametric arterial spin labelling perfusion MRI study.
abstract: The cerebral haemodynamic status of idiopathic generalized epilepsy (IGE) is a very complicated process. Little attention has been paid to cerebral blood flow (CBF) alterations in IGE detected by arterial spin labelling (ASL) perfusion magnetic resonance imaging (MRI). However, the selection of an optimal delay time is difficult for single-delay ASL. Multi-delay multi-parametric ASL perfusion MRI overcomes the limitations of single-delay ASL. We applied multi-delay multi-parametric ASL perfusion MRI to investigate the patterns of postictal cerebral perfusion in IGE patients with absence seizures. A total of 21 IGE patients with absence seizures and 24 healthy control subjects were enrolled. IGE patients exhibited prolonged arterial transit time (ATT) in the left superior temporal gyrus. The mean CBF of IGE patients was significantly increased in the left middle temporal gyrus, left parahippocampal gyrus and left fusiform gyrus. Prolonged ATT in the left superior temporal gyrus was negatively correlated with the age at onset in IGE patients. This study demonstrated that cortical dysfunction in the temporal lobe and fusiform gyrus may be related to epileptic activity in IGE patients with absence seizures. This information can play an important role in elucidating the pathophysiological mechanism of IGE from a cerebral haemodynamic perspective.
authors.affiliation: Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.|Department of Radiology, Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan Province, China.
authors.forename: Guangxiang
authors.initials: G
authors.lastname: Chen
authors.affiliation: Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Du
authors.initials: D
authors.lastname: Lei
authors.affiliation: Department of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Jiechuan
authors.initials: J
authors.lastname: Ren
authors.affiliation: Siemens Healthcare, MR Collaborations NE Asia, Beijing, China.
authors.forename: Panli
authors.initials: P
authors.lastname: Zuo
authors.affiliation: Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Xueling
authors.initials: X
authors.lastname: Suo
authors.affiliation: Department of Neurology, UCLA, Los Angeles, CA, USA.
authors.forename: Danny J J
authors.initials: DJ
authors.lastname: Wang
authors.affiliation: Department of Radiology, Henan Provincial People's Hospital &the People's Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.
authors.forename: Meiyun
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Zhou
authors.affiliation: Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Qiyong
authors.initials: Q
authors.lastname: Gong
mesh_terms: D000293:Adolescent; D000328:Adult; D001158:Arteries / Q000473:pathology*; D001921:Brain / Q000473:pathology; D001931:Brain Mapping; D016022:Case-Control Studies; D002560:Cerebrovascular Circulation; D002648:Child; D004829:Epilepsy, Generalized / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010477:Perfusion; D012640:Seizures / Q000000981:diagnostic imaging / Q000503:physiopathology; D013113:Spin Labels; D013702:Temporal Lobe / Q000473:pathology; D055815:Young Adult
chemical_list: D013113:Spin Labels