title: Influence of supplemental vitamin D on intensity of benign paroxysmal positional vertigo: A longitudinal clinical study.
abstract: BACKGROUND
  Benign paroxysmal positional vertigo (BPPV) is linked to vitamin D deficiency. This clinical trial aimed to determine the influence of vitamin D supplementation on intensity of BPPV.
  
  
  METHODS
  The study population was selected consecutively and the diagnosis of BPPV was made by history and clinical examination and exclusion of other conditions. Intensity of BPVV was assessed based on VAS score (0-10). Serum 25-hydroxyvitamin D (25-OHD) was measured using ELISA method and levels < 20 ng/ml was considered a deficiency. All patients received rehabilitation treatment using Epley's maneuver one time per week for one month. Serum 25-OHD deficient patients were classified as treated and non-treated groups (rehabilitation with or without 50.000 IU cholecalciferol weekly for two months).The results of treatment were compared with vitamin D sufficient group as control. All patients were followed-up for 6 months.
  
  
  RESULTS
  After two months of treatment, in both vitamin D treated and non-treated groups the intensity of BPPV decreased significantly as compared with control (P=0.001 for both groups) but at endpoint, the intensity of BPPV aggravated and regressed to the baseline value in vitamin D deficient non-treated group (P=0.001) whereas, in vitamin D treated group, improvement of BPPV remained stable and unchanged over the study period.
  
  
  CONCLUSIONS
  This study indicates that correction of vitamin D deficiency in BPPV provides additional benefit to rehabilitation therapy (Epley maneuver) regarding duration of improvement. These findings suggest serum 25-OHD measurement in recurrent BPPV.
authors.affiliation: Department of Audiology, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
authors.forename: Mahboobeh
authors.initials: M
authors.lastname: Sheikhzadeh
authors.affiliation: University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
authors.forename: Yones
authors.initials: Y
authors.lastname: Lotfi
authors.affiliation: Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Abdollah
authors.initials: A
authors.lastname: Mousavi
authors.affiliation: Mobility Impairment Research Center, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Behzad
authors.initials: B
authors.lastname: Heidari
authors.affiliation: Department of Audiology, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Monadi
authors.affiliation: Department of Statistics, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
authors.forename: Enayatollah
authors.initials: E
authors.lastname: Bakhshi
keywords: Benign paroxysmal positional vertigo; Intensity; Rehabilitation Therapy.; Vitamin D