title: The effect of cataract surgery on salivary melatonin and sleep quality in aging people.
abstract: Blue light plays an important role in circadian photoentrainment by stimulating the melanopsin-expressing photosensitive retinal ganglion cells. Age-related cataract causes progressive loss of blue light transmission, which may lead to changes in circadian rhythm and sleep quality. In theory, increased light transmission by cataract surgery may improve circadian misalignment and sleep quality, while the effect of cataract surgery on circadian rhythm is not well understood. In this study, we assessed 30 binocular age-related nuclear cataract patients (aged 72.5 ± 7.2, 16 female) who were eligible for cataract surgery. All the patients underwent phacoemulsification cataract extraction and neutral ultraviolet-only blocking intraocular lens (IOLs) implantation. Visual functions including best-corrected visual acuity (BCVA), color perception and dark adaptation were assessed. Salivary samples were collected at 1-hour interval from 19:00 to 23:00 48 hours before and after surgery. Salivary melatonin concentration was measured and dim light melatonin onset (DLMO) was calculated subsequently. Sleep quality and daytime alertness were assessed before and a month after surgery using Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS). All the operated eyes demonstrated significant improvements in BCVA, color perception and dark adaptation after cataract surgery. Salivary melatonin concentration at 23:00 was significantly increased after surgery (P < 0.001). However, the average DLMO did not change significantly after surgery. In addition, PSQI and ESS scores were significantly decreased a month after surgery (P = 0.027, P < 0.001, respectively). In conclusion, cataract surgery promotes blue-light transmission; consequently, it may lead to the increase in nighttime melatonin concentration and improvement in sleep quality as well as daytime alertness.
authors.affiliation: a Department of Ophthalmology , Peking University Third Hospital , Beijing , China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Shenshen
authors.affiliation: a Department of Ophthalmology , Peking University Third Hospital , Beijing , China.
authors.forename: Wang
authors.initials: W
authors.lastname: Minshu
authors.affiliation: a Department of Ophthalmology , Peking University Third Hospital , Beijing , China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Qing
authors.affiliation: b Department of Pharmacy , Peking University Third Hospital , Beijing , China.
authors.forename: Liu
authors.initials: L
authors.lastname: Yang
authors.affiliation: b Department of Pharmacy , Peking University Third Hospital , Beijing , China.
authors.forename: Zhai
authors.initials: Z
authors.lastname: Suodi
authors.affiliation: a Department of Ophthalmology , Peking University Third Hospital , Beijing , China.
authors.forename: Wang
authors.initials: W
authors.lastname: Wei
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002386:Cataract; D002387:Cataract Extraction; D005260:Female; D006801:Humans; D008027:Light; D008297:Male; D008550:Melatonin / Q000737:chemistry* / Q000378:metabolism; D012463:Saliva / Q000737:chemistry*; D012890:Sleep / Q000502:physiology*
chemical_list: D008550:Melatonin
keywords: blue light; cataract surgery; circadian rhythm; melatonin; sleep