title: Relationship between metabolites of arachidonic acid and prognosis in patients with acute coronary syndrome.
abstract: OBJECTIVE
  To investigate the correlation of arachidonic acid (ARA) metabolites and prognosis in ACS patients.
  
  
  RESULTS
  This is a mono-center retrospective nested case-control study. We followed up 470 ACS patients, of whom 39 patients had MACE in a mean follow up time of 1037days (identified as MACE group). Another 39 clinically matched patients without MACE were selected from the 470 ACS patients (Non-MACE group). Thirty-nine subjects without Coronary Heart Disease were enrolled as Control group. Metabolites of ARA were determined by LC-MS/MS. We found that plasma levels of LTB4, 8-HETE, 11-HETE, 12-HETE, and 15-HETE were significantly increased in MACE and Non-MACE groups, 5-HETE and 9-HETE were significantly increased in MACE group comparing with Control group (P<0.05). Importantly, plasma level of 19-HETE in MACE group was significantly lower than Non-MACE and Control groups. 19-HETE significantly correlated with the prognosis of ACS after adjustment for clinical characteristics (HR=0.103, 95% C.I.: 0.014-0.766). The AUC for ROC curve of 19-HETE in predicting MACE was 0.637 (P<0.05). Survival analysis showed that ACS patients with 19-HETE levels higher than 0.13ng/ml tend to have better prognosis than those lower than 0.13ng/ml (P<0.05). GRACE score and serum Fib levels were also significantly correlated with MACE. 20-HETE level was found significantly higher in STEMI group comparing with NSTE-ACS group (P<0.05).
  
  
  CONCLUSIONS
  Plasma arachidonic acid metabolites may act as prognostic markers for ACS patients.
authors.affiliation: Department of Cardiology, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, and Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Peking University Third Hospital, Beijing 100191, China.
authors.forename: Lingyun
authors.initials: L
authors.lastname: Zu
authors.affiliation: Department of Cardiology, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, and Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Peking University Third Hospital, Beijing 100191, China.
authors.forename: Ge
authors.initials: G
authors.lastname: Guo
authors.affiliation: Department of Cardiology, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, and Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Peking University Third Hospital, Beijing 100191, China.
authors.forename: Boda
authors.initials: B
authors.lastname: Zhou
authors.affiliation: Department of Cardiology, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, and Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Peking University Third Hospital, Beijing 100191, China. Electronic address: weigao@bjmu.edu.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Gao
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000175:diagnosis* / Q000378:metabolism; D000368:Aged; D016718:Arachidonic Acid / Q000097:blood / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006893:Hydroxyeicosatetraenoic Acids / Q000097:blood* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers; D006893:Hydroxyeicosatetraenoic Acids; D016718:Arachidonic Acid; C055986:19-hydroxy-5,8,11,14-eicosatetraenoic acid; C055987:20-hydroxy-5,8,11,14-eicosatetraenoic acid
keywords: 19-Hydroxyeicosatetraenoic acid (19-HETE); Acute coronary syndrome (ACS); Major adverse cardiovascular event (MACE); Metabolites of arachidonic acid (ARA)