title: Tunable Lipidoid-Telodendrimer Hybrid Nanoparticles for Intracellular Protein Delivery in Brain Tumor Treatment.
abstract: A strategy to precisely engineer lipidoid-telodendrimer binary hybrid nanoparticles that offer enhanced cell membrane permeability for therapeutic proteins to reach the intracellular targets is established. The highly controllable biochemical and physical properties of the nanoparticles make them promising for protein-based brain cancer treatment with the assistance of convection-enhanced delivery.
authors.affiliation: Department of Pharmacology, Upstate Cancer Center, State University of New York Upstate Medical University, Syracuse, NY, 13210, USA.
authors.forename: Xu
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, State University of New York Upstate Medical University, Syracuse, NY, 13210, USA.
authors.forename: Alexa
authors.initials: A
authors.lastname: Bodman
authors.affiliation: Department of Pharmacology, Upstate Cancer Center, State University of New York Upstate Medical University, Syracuse, NY, 13210, USA.
authors.forename: Changying
authors.initials: C
authors.lastname: Shi
authors.affiliation: Department of Pharmacology, Upstate Cancer Center, State University of New York Upstate Medical University, Syracuse, NY, 13210, USA.
authors.forename: Dandan
authors.initials: D
authors.lastname: Guo
authors.affiliation: Department of Pharmacology, Upstate Cancer Center, State University of New York Upstate Medical University, Syracuse, NY, 13210, USA.
authors.forename: Lili
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Pharmacology, Upstate Cancer Center, State University of New York Upstate Medical University, Syracuse, NY, 13210, USA.
authors.forename: Juntao
authors.initials: J
authors.lastname: Luo
authors.affiliation: Department of Neurosurgery, State University of New York Upstate Medical University, Syracuse, NY, 13210, USA.
authors.forename: Walter A
authors.initials: WA
authors.lastname: Hall
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D045744:Cell Line, Tumor; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D008962:Models, Theoretical; D053758:Nanoparticles / Q000737:chemistry*; D011506:Proteins / Q000008:administration & dosage* / Q000737:chemistry* / Q000627:therapeutic use
chemical_list: D008055:Lipids; D011506:Proteins
keywords: glioblastoma; lipidoids; nanoparticles; protein delivery; telodendrimers