title: Development of Neural Activity in the Enteric Nervous System: Similarities and Differences to Other Parts of the Nervous System.
abstract: All the neurons and glia of the enteric nervous system (ENS) arise from neural crest-derived cells that migrate into the gastrointestinal (GI) tract during development (Yntema and Hammond 1954; Le Douarin and Teillet 1973). Most of the ENS originates from vagal neural crest cells (NCCs), which arise from the caudal hindbrain region of the neural tube, adjacent to somites 1-7. In the developing mouse, vagal NCCs migrate into the developing oesophagus and stomach at embryonic day (E)9.5, enter the small intestine at E10.5, and colonise the developing GI tract in a rostral-to-caudal wave, reaching the anal end of the colon at E14.5 (Serbedzija et al. 1991; Kapur et al. 1992; Anderson et al. 2006). Recent evidence indicates that there is also trans-mesenteric migration of vagal NCCs, where some NCCs leave the small intestine and migrate directly across the mesentery into the colon (Nishiyama et al. 2012). Sacral NCCs also contribute to a small population of neurons and glia in the colon (Burns and Le Douarin 1998; Wang et al. 2011).
authors.affiliation: Laboratory for Enteric Neuroscience, TARGID, University of Leuven, Herestraat 49, O&N1, Box 701, Leuven, 3000, Belgium. Marlene.Hao@med.kuleuven.be.
authors.forename: Marlene
authors.initials: M
authors.lastname: M Hao
mesh_terms: D000818:Animals; D017615:Enteric Nervous System / Q000502:physiology*; D041981:Gastrointestinal Tract / Q000502:physiology*; D051379:Mice; D009432:Neural Crest / Q000502:physiology; D055495:Neurogenesis / Q000502:physiology; D009457:Neuroglia / Q000502:physiology*; D009474:Neurons / Q000502:physiology*