title: A CASE OF GRANISETRON ASSOCIATED INTRAOPERATIVE CARDIAC ARREST.
abstract: We report a case of intraoperative severe bradycardia that resulted in asystole and cardiac arrest shortly after (<2 min) intravenous granisetron 1mg for postoperative nausea and vomiting prophylaxis, that occurred in a female patient who underwent an elective total thyroidectomy. After two cycles of cardiopulmonary resuscitation and defibrillation, spontaneous circulation and sinus rhythm returned successfully. Postoperatively, the patient was diagnosed with a drug-induced long QT syndrome. At the time of the event, granisetron was the only medication administered. Furthermore, there was no reason to suspect electrolyte abnormalities. We explore the association of the onset of severe sinus bradycardia with the intravenous administration of granisetron.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Al Harbi
authors.forename: Derar
authors.initials: D
authors.lastname: Al Rifai
authors.forename: Hassan
authors.initials: H
authors.lastname: Al Habeeb
authors.forename: Freddie
authors.initials: F
authors.lastname: Wambi
authors.forename: Georges
authors.initials: G
authors.lastname: Geldhof
authors.forename: Vassilios
authors.initials: V
authors.lastname: Dimitriou
mesh_terms: D000932:Antiemetics / Q000009:adverse effects*; D005260:Female; D017829:Granisetron / Q000009:adverse effects*; D006323:Heart Arrest / Q000139:chemically induced*; D006801:Humans; D007431:Intraoperative Complications / Q000139:chemically induced*; D008875:Middle Aged
chemical_list: D000932:Antiemetics; D017829:Granisetron