title: Mammary gland and radiation: Knowns and unknowns.
abstract: Effective breast cancer management and decreasing breast cancer fatalities is contingent upon reliable diagnostic procedures and treatment modalities, including those based on ionizing radiation. On the one hand, ionizing radiation is widely used for cancer diagnostics and therapy, on the other hand it is genotoxic cancer-causing agent. Here we discuss recent studies on the effects of low (diagnostic) and high (treatment) doses of ionizing radiation on healthy breast cells, breast cancer cells, and cancer cells resistant to common drug therapies.
authors.affiliation: a Department of Biological Sciences , University of Lethbridge , Lethbridge , AB , Canada.
authors.forename: Lidia
authors.initials: L
authors.lastname: Luzhna
authors.affiliation: a Department of Biological Sciences , University of Lethbridge , Lethbridge , AB , Canada.
authors.forename: Olga
authors.initials: O
authors.lastname: Kovalchuk
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics / Q000532:radiotherapy; D004307:Dose-Response Relationship, Radiation; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic / Q000528:radiation effects; D006801:Humans; D042361:Mammary Glands, Human / Q000528:radiation effects*; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D011839:Radiation, Ionizing; D014057:Tomography, X-Ray Computed / Q000009:adverse effects
chemical_list: D035683:MicroRNAs
keywords: breast cancer; epigenetics; gene expression; ionizing radiation; mammary gland; microRNA