title: Self-Sufficient Formaldehyde-to-Methanol Conversion by Organometallic Formaldehyde Dismutase Mimic.
abstract: The catalytic networks of methylotrophic organisms, featuring redox enzymes for the activation of one-carbon moieties, can serve as great inspiration in the development of novel homogeneously catalyzed pathways for the interconversion of C1 molecules at ambient conditions. An imidazolium-tagged arene-ruthenium complex was identified as an effective functional mimic of the bacterial formaldehyde dismutase, which provides a new and highly selective route for the conversion of formaldehyde to methanol in absence of any external reducing agents. Moreover, secondary amines are reductively methylated by the organometallic dismutase mimic in a redox self-sufficient manner with formaldehyde acting both as carbon source and reducing agent.
authors.affiliation: Department für Chemie, Universität zu Köln, Greinstrasse 6, 50939, Cologne, Germany.
authors.forename: Dominic
authors.initials: D
authors.lastname: van der Waals
authors.affiliation: Department für Chemie, Universität zu Köln, Greinstrasse 6, 50939, Cologne, Germany.
authors.forename: Leo E
authors.initials: LE
authors.lastname: Heim
authors.affiliation: Department für Chemie, Universität zu Köln, Greinstrasse 6, 50939, Cologne, Germany.
authors.forename: Simona
authors.initials: S
authors.lastname: Vallazza
authors.affiliation: Department für Chemie, Universität zu Köln, Greinstrasse 6, 50939, Cologne, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Gedig
authors.affiliation: Department of Chemistry, Aalto-yliopisto, Kemistintie 1, 02150, Espoo, Finland.
authors.forename: Jan
authors.initials: J
authors.lastname: Deska
authors.affiliation: Department für Chemie, Universität zu Köln, Greinstrasse 6, 50939, Cologne, Germany. martin.prechtl@uni-koeln.de.
authors.forename: Martin H G
authors.initials: MH
authors.lastname: Prechtl
mesh_terms: D000429:Alcohol Oxidoreductases / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D001419:Bacteria / Q000737:chemistry* / Q000378:metabolism; D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry* / Q000378:metabolism; D000432:Methanol / Q000737:chemistry*; D010084:Oxidation-Reduction; D012428:Ruthenium / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000588:Amines; D056831:Coordination Complexes; D012428:Ruthenium; D000429:Alcohol Oxidoreductases; C048530:formaldehyde dismutase; D000432:Methanol
keywords: biocatalysis; ionic liquids; methanol; reductive methylation; ruthenium