title: Proteome analysis of adrenal cortical tumors.
abstract: Adrenal tumor is a relatively common tumor. The discrimination between adrenal cortical adenoma (ACA) and adrenal cortical carcinoma (ACC) is crucial as these two diseases have distinct prognosis. ACA is a benign tumor curable by surgical excision, while the prognosis of ACC is extremely poor, with a 5-year mortality of 75-90%. Therefore, previous proteomic studies focused on markers allowing the differentiation between ACA and ACC.
  
  
  
  Several proteomic approaches based on the analysis of various samples such as human tissues, urine, and cell lines. In this review, we focused on proteomic studies performed to improve adrenal tumor diagnosis and identify ACC therapeutic targets. Expert commentary: The rapid development of cancer genomics provided a lot of information, which affects functional proteomics. In practice, differentially expressed proteins between ACA and ACC have been suggested in several proteomic studies and had a biologic implication in ACC.
authors.affiliation: a Department of Pathology , Yonsei University College of Medicine , Seoul , South Korea.
authors.forename: Hye Min
authors.initials: HM
authors.lastname: Kim
authors.affiliation: a Department of Pathology , Yonsei University College of Medicine , Seoul , South Korea.
authors.forename: Yu Kyung
authors.initials: YK
authors.lastname: Lee
authors.affiliation: a Department of Pathology , Yonsei University College of Medicine , Seoul , South Korea.
authors.forename: Ja Seung
authors.initials: JS
authors.lastname: Koo
mesh_terms: D018246:Adrenocortical Adenoma / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D018268:Adrenocortical Carcinoma / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D006801:Humans; D011379:Prognosis; D020543:Proteome / Q000235:genetics*; D040901:Proteomics
chemical_list: D020543:Proteome
keywords: Adrenal cortical tumor; adrenal cortical adenoma; adrenal cortical carcinoma; diagnosis; mass spectrometry; proteomics