title: Certolizumab pegol for treating axial spondyloarthritis.
abstract: Axial spondyloarthritis (axSpA) is a chronic inflammatory disease of the spine and sacroiliac (SI) joints. The spectrum of axSpA includes ankylosing spondylitis (AS) and non-radiographic axSpA (nr-axSpA). Evidence has supported the use of TNF alpha inhibitors (TNFi) in treating these diseases, with good efficacy and tolerable safety profiles. Certolizumab pegol (CZP) is an anti-TNF alpha (TNFa) agent with data to support its use in both AS and nr-axSpA.
  
  
  
  The pharmacologic properties of CZP were reviewed. Data regarding the use and efficacy of CZP in axSpA were reviewed. Quality of life outcomes and safety profiles of CZP in axSpA patients were discussed as well.
  
  
  
  While there are several biologics with evidence for improved outcomes in AS, there is less evidence for biologic medications that have good efficacy in nr-axSpA. CZP has good evidence of improved outcomes in terms of clinical efficacy, patient reported outcomes and imaging outcomes in both conditions, with a tolerable safety profile.
authors.affiliation: a Division of Arthritis & Rheumatic Diseases , Oregon Health & Sciences University , Portland , OR , USA.
authors.forename: Julianna
authors.initials: J
authors.lastname: Desmarais
authors.affiliation: a Division of Arthritis & Rheumatic Diseases , Oregon Health & Sciences University , Portland , OR , USA.|b Department of Pharmacy , Oregon Health & Sciences University , Portland , OR , USA.
authors.forename: Secia
authors.initials: S
authors.lastname: Beier
authors.affiliation: a Division of Arthritis & Rheumatic Diseases , Oregon Health & Sciences University , Portland , OR , USA.
authors.forename: Atul
authors.initials: A
authors.lastname: Deodhar
mesh_terms: D000818:Animals; D000068582:Certolizumab Pegol / Q000627:therapeutic use*; D006801:Humans; D011788:Quality of Life; D025241:Spondylarthritis / Q000188:drug therapy*; D013167:Spondylitis, Ankylosing / Q000188:drug therapy; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: D014409:Tumor Necrosis Factor-alpha; D000068582:Certolizumab Pegol
keywords: Axial spondyloarthritis; ankylosing spondylitis; certolizumab pegol; non-radiographic spondyloarthritis