title: Living donor liver transplantation for biliary atresia - An Indian experience.
abstract: LT has played a significant role in improving the outcome of children with BA. We review our five-yr experience of LDLT for children with BA. Records of all children who underwent LDLT in our institution over a five-yr period (August 2010-June 2015) were reviewed and those with a primary diagnosis of BA were selected for our study. Data were extracted from a prospectively maintained database. Additional data were collected by review of case notes and imaging studies. Analysis was carried out using standard statistical means. One hundred and thirty-two children underwent LDLT at our center over the study period, of which 58 children (31 females) had a primary diagnosis of BA. Thirty-three (56.9%) children had undergone a prior KPE and 25 (43.1%) had a primary LT. Thirty-four children had at least one post-op complication, of which 13 had minor complications (Clavien grades I and II) and 21 had major complications (Clavien grade >II). Thirty-day survival was 96.6% and one-yr survival was 91.4%. Univariate analysis of variables comparing children who did and did not have a KPE prior to LT showed that age at LT, weight at LT, PELD, and GRWR were significantly different. LDLT provides excellent outcomes in children with BA. Primary LDLT and LT after KPE provide equivalent results, although the former is technically more challenging as the child is younger.
authors.affiliation: Institute of Liver Disease and Transplantation, Global Health City, Perumbakkam, Chennai, Tamil Nadu, India.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Safwan
authors.affiliation: Institute of Liver Disease and Transplantation, Global Health City, Perumbakkam, Chennai, Tamil Nadu, India.|National Foundation for Liver Research, Perumbakkam, Chennai, Tamil Nadu, India.
authors.forename: Priya
authors.initials: P
authors.lastname: Ramachandran
authors.affiliation: Institute of Liver Disease and Transplantation, Global Health City, Perumbakkam, Chennai, Tamil Nadu, India.
authors.forename: Mettu Srinivas
authors.initials: MS
authors.lastname: Reddy
authors.affiliation: Institute of Liver Disease and Transplantation, Global Health City, Perumbakkam, Chennai, Tamil Nadu, India.|National Foundation for Liver Research, Perumbakkam, Chennai, Tamil Nadu, India.
authors.forename: Naresh
authors.initials: N
authors.lastname: Shanmugam
authors.affiliation: Institute of Liver Disease and Transplantation, Global Health City, Perumbakkam, Chennai, Tamil Nadu, India.|National Foundation for Liver Research, Perumbakkam, Chennai, Tamil Nadu, India.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Rela
mesh_terms: D001656:Biliary Atresia / Q000401:mortality / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D016208:Databases, Factual; D005260:Female; D006801:Humans; D007194:India; D007223:Infant; D007231:Infant, Newborn; D017093:Liver Failure / Q000401:mortality / Q000601:surgery*; D016031:Liver Transplantation / Q000379:methods*; D019520:Living Donors; D008297:Male; D011446:Prospective Studies; D016896:Treatment Outcome
keywords: Kasai portoenterostomy; biliary atresia; living donor liver transplantation; pediatric transplantation