title: FGFs: crucial factors that regulate tumour initiation and progression.
abstract: Fibroblast growth factors (FGFs) are crucial signalling molecules involved in normal cell growth, differentiation and proliferation. Over the past few decades, a large body of research has illustrated effects of individual FGFs on tumour initiation and progression. Tumour development is commonly accompanied with generation of new blood and lymph vessels, which support enhanced cell proliferation. Moreover, acquisition of tumour cells of the epithelial-mesenchymal transition (EMT) phenotype, enhances tumour cell migration and invasion potentials, crucial steps in tumour metastasis. This review summarizes recent findings concerning roles of FGFs in angiogenesis, lymphangiogenesis and EMT.
authors.affiliation: School of Biomedical Sciences, Chengdu Medical College, Chengdu, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Jing
authors.affiliation: School of Biomedical Sciences, Chengdu Medical College, Chengdu, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: School of Biomedical Sciences, Chengdu Medical College, Chengdu, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Liu
authors.affiliation: School of Biomedical Sciences, Chengdu Medical College, Chengdu, China.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Deng
authors.affiliation: School of Biomedical Sciences, Chengdu Medical College, Chengdu, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Jiang
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Liu
authors.affiliation: School of Biomedical Sciences, Chengdu Medical College, Chengdu, China.
authors.forename: Haixing
authors.initials: H
authors.lastname: Song
authors.affiliation: School of Biomedical Sciences, Chengdu Medical College, Chengdu, China.
authors.forename: Jingyi
authors.initials: J
authors.lastname: Li
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D049109:Cell Proliferation; D018450:Disease Progression; D058750:Epithelial-Mesenchymal Transition; D005346:Fibroblast Growth Factors / Q000032:analysis / Q000235:genetics / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D042583:Lymphangiogenesis; D009369:Neoplasms / Q000098:blood supply / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D015398:Signal Transduction
chemical_list: D005346:Fibroblast Growth Factors