title: Angle correction for small animal tumor imaging with spatial frequency domain imaging (SFDI).
abstract: Spatial frequency domain imaging (SFDI) is a widefield imaging technique that allows for the quantitative extraction of tissue optical properties. SFDI is currently being explored for small animal tumor imaging, but severe imaging artifacts occur for highly curved surfaces (e.g. the tumor edge). We propose a modified Lambertian angle correction, adapted from the Minnaert correction method for satellite imagery, to account for tissue surface angles up to 75°. The method was tested in a hemisphere phantom study as well as a small animal tumor model. The proposed method reduced µa and µs` extraction errors by an average of 64% and 16% respectively compared to performing no angle correction, and provided more physiologically agreeable optical property and chromophore values on tumors.
authors.affiliation: Boston University, Department of Biomedical Engineering, 44 Cummington Mall, Boston, Massachusetts 02215, USA.
authors.forename: Yanyu
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Boston University, Department of Electrical & Computer Engineering, 8 Saint Mary's Street, Boston, Massachusetts 02215, USA.
authors.forename: Syeda
authors.initials: S
authors.lastname: Tabassum
authors.affiliation: Boston University, Department of Biomedical Engineering, 44 Cummington Mall, Boston, Massachusetts 02215, USA.
authors.forename: Shaheer
authors.initials: S
authors.lastname: Piracha
authors.affiliation: Brigham and Women's Hospital, Harvard Medical School, 4 Blackfan Circle, Boston, Massachusetts 02115, USA.
authors.forename: Mohan Sobhana
authors.initials: MS
authors.lastname: Nandhu
authors.affiliation: Brigham and Women's Hospital, Harvard Medical School, 4 Blackfan Circle, Boston, Massachusetts 02115, USA.
authors.forename: Mariano
authors.initials: M
authors.lastname: Viapiano
authors.affiliation: Boston University, Department of Biomedical Engineering, 44 Cummington Mall, Boston, Massachusetts 02215, USA.
authors.forename: Darren
authors.initials: D
authors.lastname: Roblyer
keywords: (170.0110) Imaging systems; (170.3880) Medical and biological imaging; (170.5280) Photon migration; (290.1990) Diffusion