title: Stability of Cefepime in pH-Neutral Peritoneal Dialysis Solutions Packaged in Dual-Compartment Bags.
abstract: Intraperitoneal cefepime is used for the treatment of peritoneal dialysis (PD)-associated peritonitis caused by gram-negative bacteria. The current study investigated the stability of cefepime in a pH-neutral PD solution. A reconstituted solution of cefepime was injected into a total of 9 PD bags and stored at 4°C, 25°C or 37°C for various time points. Cefepime retained more than 90% of its initial concentration for 168, 96, and 12 hours at 4°C, 25°C and 37°C, respectively. No apparent physical precipitation or pH change was observed during the study. This study provides crucial information to healthcare professionals on the physical and chemical stability of cefepime in the pH-neutral solution to help them in preparing such admixtures in advance where required.
authors.affiliation: Pharmacy, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia.
authors.forename: Farzana
authors.initials: F
authors.lastname: Yousaf
authors.affiliation: Pharmacy, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia.
authors.forename: Syed T R
authors.initials: ST
authors.lastname: Zaidi
authors.affiliation: Pharmacy, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia Medicine, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia Department of Pharmacy, Royal Hobart Hospital, Hobart, Tasmania, Australia.
authors.forename: Troy
authors.initials: T
authors.lastname: Wanandy
authors.affiliation: Medicine, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia Department of Nephrology, Royal Hobart Hospital, Hobart, Tasmania, Australia.
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Jose
authors.affiliation: Pharmacy, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia Rahul.Patel@utas.edu.au.
authors.forename: Rahul P
authors.initials: RP
authors.lastname: Patel
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D000077723:Cefepime; D002511:Cephalosporins / Q000737:chemistry*; D015314:Dialysis Solutions / Q000737:chemistry*; D004349:Drug Packaging; D004355:Drug Stability; D006801:Humans; D010530:Peritoneal Dialysis
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D015314:Dialysis Solutions; D000077723:Cefepime
keywords: Cefepime; compatibility; pH neutral; peritoneal dialysis; peritonitis; stability