title: Therapeutic options in papillary thyroid carcinoma: current guidelines and future perspectives.
abstract: The treatment of papillary thyroid cancer is now based on individual patient risk and response to therapies. Molecular techniques are increasingly being used to risk stratify and to guide therapeutic decisions. There have been advances in the treatment of local disease through surgery or radioiodine. Directed techniques can target metastatic disease including bisphosphonates, radiofrequency ablation or radiotherapy. Systemic therapies such as tyrosine kinase inhibitors show great promise although such treatment must be individualized. Future therapies will target treating radioiodine refractory disease.
authors.affiliation: Department of Endocrinology, Royal North Shore Hospital, Sydney, Australia.
authors.forename: Emma
authors.initials: E
authors.lastname: Scott
authors.affiliation: Department of Endocrinology, Royal North Shore Hospital, Sydney, Australia.|University of Sydney, Sydney, Australia.
authors.forename: Diana
authors.initials: D
authors.lastname: Learoyd
authors.affiliation: Department of Endocrinology, Royal North Shore Hospital, Sydney, Australia.|University of Sydney, Sydney, Australia.|Cancer Genetics Laboratory, Hormones & Cancer Group, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, Australia.
authors.forename: Roderick J
authors.initials: RJ
authors.lastname: Clifton-Bligh
mesh_terms: D002277:Carcinoma / Q000188:drug therapy* / Q000453:epidemiology / Q000473:pathology / Q000532:radiotherapy; D002291:Carcinoma, Papillary; D004164:Diphosphonates / Q000627:therapeutic use; D017408:Guidelines as Topic; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D009362:Neoplasm Metastasis; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D012307:Risk Factors; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000188:drug therapy* / Q000453:epidemiology / Q000473:pathology / Q000532:radiotherapy
chemical_list: D004164:Diphosphonates; D007457:Iodine Radioisotopes; D047428:Protein Kinase Inhibitors
keywords: BRAF; TERT; papillary thyroid cancer; radioactive iodine; tyrosine kinase inhibitors