title: Changes in triglyceride, HDL-C, and non-HDL-C levels in patients with acute coronary syndrome.
abstract: BACKGROUND
  Changes in high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) levels have been linked to residual cardiovascular risk, whereas non-HDL-C levels have been shown to be more predictive of cardiovascular risk than are low-density lipoprotein cholesterol (LDL-C) levels. We aimed to investigate the impact of HDL-C, TG, and non-HDL-C levels on acute coronary syndrome (ACS) risk with on-target LDL-C levels.
  
  
  METHODS
  In all, 424 Caucasian patients aged over 50 years who had LDL-C levels below 3.4 mmol/l with a first or subsequent ACS event were enrolled in a multicenter, retrospective study. Lipid samples were collected within 4 days after the cardiovascular event. The subjects of the age-matched, gender-balanced control group (n = 443) had LDL-C levels below 3.4 mmol/l and were free of cardiovascular diseases.
  
  
  RESULTS
  Patients with ACS had significantly higher TG and lower HDL-C levels compared with the control patients; however, we did not find any significant difference regarding non-HDL-C levels between the two groups. In regression analysis, the risk of coronary heart disease increased significantly with 1 standard deviation (SD) increase in TG and 1 SD decrease in HDL-C levels.
  
  
  CONCLUSIONS
  High TG and low HDL-C levels may contribute to residual cardiovascular risk in patients with well-controlled LDL-C levels; however, non-HDL-C levels at admission did not seem to be predictive for patients with ACS. Detection and treatment of secondary lipid targets such as high TG and low HDL-C levels may be important for the prevention of cardiovascular diseases.
authors.affiliation: Department of Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032, Debrecen, Hungary.
authors.forename: Péter
authors.initials: P
authors.lastname: Koncsos
authors.affiliation: Department of Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032, Debrecen, Hungary.
authors.forename: Péter
authors.initials: P
authors.lastname: Fülöp
authors.affiliation: Department of Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032, Debrecen, Hungary.
authors.forename: Imre
authors.initials: I
authors.lastname: Juhász
authors.affiliation: Faculty of Public Health, University of Debrecen, Debrecen, Hungary.
authors.forename: Klára
authors.initials: K
authors.lastname: Bíró
authors.affiliation: 2nd Department of Medicine, Cardiology, Pándy Kálmán County Hospital, Gyula, Hungary.
authors.forename: László
authors.initials: L
authors.lastname: Márk
authors.affiliation: 3rd Department of Medicine, Cardiology, Flór Ferenc County Hospital, Kistarcsa, Hungary.
authors.forename: Gábor
authors.initials: G
authors.lastname: Simonyi
authors.affiliation: Department of Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032, Debrecen, Hungary. paragh@belklinika.com.
authors.forename: György
authors.initials: G
authors.lastname: Paragh
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D005260:Female; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D015203:Reproducibility of Results; D012307:Risk Factors; D012680:Sensitivity and Specificity; D014280:Triglycerides / Q000097:blood*
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides
keywords: Acute coronary syndrome; High-density lipoprotein cholesterol; Non-high-density lipoprotein cholesterol; Residual cardiovascular risk; Triglyceride