title: Successful birth of South India's first twins after preimplantation genetic screening of embryos.
abstract: We report the first documented successful birth of twins following preimplantation genetic screening (PGS) of cleavage stage embryos by array comparative genomic hybridization (CGH) technology, in South India. The case was a 28-year-old woman with the previous history of preclinical pregnancy and a miscarriage in two attempted in vitro fertilization cycles. Day 3 cleavage stage embryos were generated by conventional long protocol with the use of a gonadotropin-releasing hormone analog and a combination of recombinant folliculotropins and human menopausal gonadotropins. Intracytoplasmic sperm injection of oocytes thus obtained was performed, and 10 selected embryos underwent PGS using the array CGH technique. Two normal blastocysts were transferred to the patient, and she conceived twins. She delivered at 35 weeks of gestation by elective cesarean on November 19, 2014. She delivered a healthy male and female baby weighing 2.19 kg and 2.26 kg, respectively. Postnatal evaluation of babies was also normal, and the hospital course was uneventful. PGS has a definitive indication in assisted reproductive technology programs and can be utilized to improve pregnancy rates significantly.
authors.affiliation: Fertility Research Centre, GG Hospital, Chennai, Tamil Nadu, India.
authors.forename: Priya
authors.initials: P
authors.lastname: Selvaraj
authors.affiliation: Fertility Research Centre, GG Hospital, Chennai, Tamil Nadu, India.
authors.forename: Kamala
authors.initials: K
authors.lastname: Selvaraj
authors.affiliation: Fertility Research Centre, GG Hospital, Chennai, Tamil Nadu, India.
authors.forename: Kalaichelvi
authors.initials: K
authors.lastname: Srinivasan
authors.affiliation: Fertility Research Centre, GG Hospital, Chennai, Tamil Nadu, India.
authors.forename: Mahalakshmi
authors.initials: M
authors.lastname: Sivakumar
keywords: Abnormal embryos; embryo biopsy; genetic screening; preimplantation genetic screening