title: Polydopamine-Functionalized Graphene Oxide Loaded with Gold Nanostars and Doxorubicin for Combined Photothermal and Chemotherapy of Metastatic Breast Cancer.
abstract: Breast cancer is the leading cancer type diagnosed in the female population, and cancer metastasis is the main reason for cancer-caused mortality. A novel nanoplatform is herein presented integrating polydopamine-functionalized nanosized reduced graphene oxide (NRGO), gold nanostars (GNS), and doxorubicin (DOX) (denoted as NRGO-GNS@DOX) for combinational treatment of metastatic breast cancer. Upon localized near infrared (NIR) laser irradiation, the NRGO-GNS@DOX nanocomposites induce significant cytotoxicity in 4T1 breast cancer cells due to a cumulative therapy effect of NRGO-GNS-elicited hyperthermia and DOX-induced cytotoxicity. Antitumor studies in orthotopic 4T1 breast tumor-bearing nude mice demonstrate that NRGO-GNS@DOX in combination with NIR laser irradiation inhibit the tumor growth and suppress the lung metastasis. Contribution of DOX-caused apoptosis of the cancer cells and hyperthermia-induced deconstruction of the tumor-associated blood vessels may account for the superior antitumor performance of the NRGO-GNS@DOX nanocomposites. These results imply a good potential of NRGO-GNS@DOX for combined photothermal and chemotherapy of the metastatic cancer.
authors.affiliation: School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241, P. R. China.
authors.forename: Fengyang
authors.initials: F
authors.lastname: Wang
authors.affiliation: School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241, P. R. China.
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Sun
authors.affiliation: Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Feng
authors.affiliation: School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241, P. R. China. zaxu@chem.ecnu.edu.cn.
authors.forename: Zhiai
authors.initials: Z
authors.lastname: Xu
authors.affiliation: School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241, P. R. China.
authors.forename: Junying
authors.initials: J
authors.lastname: Zhang
authors.affiliation: School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241, P. R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Xu
authors.affiliation: School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241, P. R. China.
authors.forename: Linlin
authors.initials: L
authors.lastname: Lu
authors.affiliation: Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
authors.forename: Haijun
authors.initials: H
authors.lastname: Yu
authors.affiliation: Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
authors.forename: Mingwei
authors.initials: M
authors.lastname: Wang
authors.affiliation: Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Li
authors.affiliation: School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241, P. R. China. wzhang@chem.ecnu.edu.cn.
authors.forename: Wen
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D006108:Graphite / Q000737:chemistry / Q000494:pharmacology; D006979:Hyperthermia, Induced / Q000379:methods*; D007211:Indoles / Q000737:chemistry; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D053761:Nanocomposites / Q000737:chemistry / Q000627:therapeutic use; D009362:Neoplasm Metastasis; D010789:Phototherapy / Q000379:methods*; D011108:Polymers / Q000737:chemistry
chemical_list: D007211:Indoles; D011108:Polymers; C568283:polydopamine; D006108:Graphite; D004317:Doxorubicin
keywords: chemotherapy; dopamine; gold nanostar; graphene oxide; photothermal therapy