title: Genetically Different Highly Pathogenic Avian Influenza A(H5N1) Viruses in West Africa, 2015.
abstract: To trace the evolution of highly pathogenic influenza A(H5N1) virus in West Africa, we sequenced genomes of 43 viruses collected during 2015 from poultry and wild birds in 5 countries. We found 2 co-circulating genetic groups within clade 2.3.2.1c. Mutations that may increase adaptation to mammals raise concern over possible risk for humans.
authors.forename: Luca
authors.initials: L
authors.lastname: Tassoni
authors.forename: Alice
authors.initials: A
authors.lastname: Fusaro
authors.forename: Adelaide
authors.initials: A
authors.lastname: Milani
authors.forename: Philippe
authors.initials: P
authors.lastname: Lemey
authors.forename: Joseph Adongo
authors.initials: JA
authors.lastname: Awuni
authors.forename: Victoria Bernice
authors.initials: VB
authors.lastname: Sedor
authors.forename: Otilia
authors.initials: O
authors.lastname: Dogbey
authors.forename: Abraham Nii Okai
authors.initials: AN
authors.lastname: Commey
authors.forename: Clement
authors.initials: C
authors.lastname: Meseko
authors.forename: Tony
authors.initials: T
authors.lastname: Joannis
authors.forename: Germaine L
authors.initials: GL
authors.lastname: Minoungou
authors.forename: Lassina
authors.initials: L
authors.lastname: Ouattara
authors.forename: Abdoul Malick
authors.initials: AM
authors.lastname: Haido
authors.forename: Diarra
authors.initials: D
authors.lastname: Cisse-Aman
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Couacy-Hymann
authors.forename: Gwenaelle
authors.initials: G
authors.lastname: Dauphin
authors.forename: Giovanni
authors.initials: G
authors.lastname: Cattoli
authors.forename: Isabella
authors.initials: I
authors.lastname: Monne
mesh_terms: D000354:Africa, Western / Q000453:epidemiology; D000818:Animals; D014644:Genetic Variation; D016679:Genome, Viral; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity; D005585:Influenza in Birds / Q000453:epidemiology* / Q000821:virology*; D009154:Mutation; D010802:Phylogeny; D011200:Poultry / Q000821:virology*; D014774:Virulence; D000073336:Whole Genome Sequencing
chemical_list: D019267:Hemagglutinin Glycoproteins, Influenza Virus
keywords: Africa; H5N1 subtype; HPAI; Influenza A virus; West Africa; genetic groups; highly pathogenic avian influenza; phylogeny; respiratory infections; viruses