title: Impact of Platelet-to-Lymphocyte Ratio on Clinical Outcomes in Patients With ST-Segment Elevation Myocardial Infarction.
abstract: We investigated the association between platelet-to-lymphocyte ratio (PLR) and clinical outcomes (including all-cause mortality, recurrent myocardial infarction, heart failure, serious cardiac arrhythmias and ischemic stroke) in patients with ST-segment elevation myocardial infarction (STEMI). Based on PLR quartiles, 5886 patients with STEMI were categorized into 4 groups: <98.8 (n = 1470), 98.8 to 125.9 (n = 1474), 126.0 to 163.3 (n = 1478), >163.3 (n = 1464), respectively. We used Cox proportional hazards models to examine the relation between PLR and clinical outcomes. Mean duration of follow-up was 81.6 months, and 948 patients (16.1%) died during follow-up. The lowest mortality occurred in the lowest PLR quartile group ( P = 0.006), with an adjusted hazard ratio of 1.18 (95% confidence interval [CI], 1.04-1.55), 1.31 (95% CI, 1.18-1.64), and 1.59 (95% CI, 1.33-1.94) in patients with PLR of 98.8 to 125.9, 126.0 to 163.3, >163.3, respectively. Higher levels of PLR were also associated with recurrent myocardial infarction ( Ptrend= .023), heart failure ( Ptrend= .018), and ischemic stroke ( Ptrend= .043). In conclusion, a higher PLR was associated with recurrent myocardial infarction, heart failure, ischemic stroke, and all-cause mortality in patients with STEMI.
authors.affiliation: 1 Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Xi-Peng
authors.initials: XP
authors.lastname: Sun
authors.affiliation: 1 Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: 1 Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Zhu
authors.affiliation: 2 Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
authors.forename: Dong-Bao
authors.initials: DB
authors.lastname: Li
authors.affiliation: 2 Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.affiliation: 2 Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Li
authors.affiliation: 3 Department of Cardiology, Beijing Luhe Hospital, Capital Medical University, Beijing, China.
authors.forename: Wen-Ming
authors.initials: WM
authors.lastname: Chen
authors.affiliation: 1 Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Hua
mesh_terms: D001145:Arrhythmias, Cardiac / Q000209:etiology; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets; D002423:Cause of Death; D003287:Contrast Media; D017023:Coronary Angiography; D005260:Female; D006333:Heart Failure / Q000209:etiology; D006801:Humans; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention; D012008:Recurrence; D012189:Retrospective Studies; D000072657:ST Elevation Myocardial Infarction / Q000097:blood* / Q000401:mortality / Q000628:therapy*; D020521:Stroke / Q000209:etiology; D016896:Treatment Outcome; D014283:Triiodobenzoic Acids
chemical_list: D015415:Biomarkers; D003287:Contrast Media; D014283:Triiodobenzoic Acids; C044834:iodixanol
keywords: ST-segment elevation myocardial infarction; clinical outcomes; platelet-to-lymphocyte ratio