title: Influence of Radiation Exposure During Radiotherapy. Evidence for the Increase of Versican and Heparin-Binding EGF-like Growth Factor Concentrations.
abstract: OBJECTIVE
  To investigate the reaction of versican and heparin-binding EGF-like growth factor (HB-EGF) molecule concentrations to acute radiation exposure in normal bladder and rectal tissue samples in order to gain more insight into the effects of cancer radiotherapy.
  
  
  METHODS
  Four groups with 6 male adult Swiss Albino mice per group were investigated. The mice bladder and rectum tissue samples were subjected to a 10-Gy single-dose radiation exposure in the pelvic region with a Co-60 teletherapy device and investigated 1, 2, and 7 days after radiation exposure, with 1 reference group which was not exposed to radiation.
  
  
  RESULTS
  In the immunohistochemical examination of the tissue samples with anti-versican and anti-HB-EGF primary antibodies was observed a statistically significant increase 7 days after radiation exposure.
  
  
  CONCLUSIONS
  The observed increase of versican and HB-EGF concentrations in the normal tissue matrix after radiation exposure may play a role in the side effects of radiotherapy.
authors.forename: Mahmut Kemal
authors.initials: MK
authors.lastname: Ozbilgin
authors.forename: Caner
authors.initials: C
authors.lastname: Aktas
authors.forename: Elgin Turkoz
authors.initials: ET
authors.lastname: Uluer
authors.forename: Mustafa Cagatay
authors.initials: MC
authors.lastname: Buyukuysal
authors.forename: Manuchehr Salehi
authors.initials: MS
authors.lastname: Gareveran
authors.forename: Cengiz
authors.initials: C
authors.lastname: Kurtman
mesh_terms: D000818:Animals; D066257:Heparin-binding EGF-like Growth Factor / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D011878:Radiotherapy; D012007:Rectum / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects*; D013997:Time Factors; D015854:Up-Regulation; D001743:Urinary Bladder / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects*; D053675:Versicans / Q000378:metabolism*
chemical_list: C587884:Hbegf protein, mouse; D066257:Heparin-binding EGF-like Growth Factor; C508323:Vcan protein, mouse; D053675:Versicans