title: TBC2health: a database of experimentally validated health-beneficial effects of tea bioactive compounds.
abstract: Tea is one of the most consumed beverages in the world. Considerable studies show the exceptional health benefits (e.g. antioxidation, cancer prevention) of tea owing to its various bioactive components. However, data from these extensively published papers had not been made available in a central database. To lay a foundation in improving the understanding of healthy tea functions, we established a TBC2health database that currently documents 1338 relationships between 497 tea bioactive compounds and 206 diseases (or phenotypes) manually culled from over 300 published articles. Each entry in TBC2health contains comprehensive information about a bioactive relationship that can be accessed in three aspects: (i) compound information, (ii) disease (or phenotype) information and (iii) evidence and reference. Using the curated bioactive relationships, a bipartite network was reconstructed and the corresponding network (or sub-network) visualization and topological analyses are provided for users. This database has a user-friendly interface for entry browse, search and download. In addition, TBC2health provides a submission page and several useful tools (e.g. BLAST, molecular docking) to facilitate use of the database. Consequently, TBC2health can serve as a valuable bioinformatics platform for the exploration of beneficial effects of tea on human health. TBC2health is freely available at http://camellia.ahau.edu.cn/TBC2health.
authors.forename: Shihua
authors.initials: S
authors.lastname: Zhang
authors.forename: Hongdong
authors.initials: H
authors.lastname: Xuan
authors.forename: Liang
authors.initials: L
authors.lastname: Zhang
authors.forename: Sicong
authors.initials: S
authors.lastname: Fu
authors.forename: Yijun
authors.initials: Y
authors.lastname: Wang
authors.forename: Hua
authors.initials: H
authors.lastname: Yang
authors.forename: Yuling
authors.initials: Y
authors.lastname: Tai
authors.forename: Youhong
authors.initials: Y
authors.lastname: Song
authors.forename: Jinsong
authors.initials: J
authors.lastname: Zhang
authors.forename: Chi-Tang
authors.initials: CT
authors.lastname: Ho
authors.forename: Shaowen
authors.initials: S
authors.lastname: Li
authors.forename: Xiaochun
authors.initials: X
authors.lastname: Wan
mesh_terms: D019295:Computational Biology; D016208:Databases, Factual; D006801:Humans; D062105:Molecular Docking Simulation; D013662:Tea; D014584:User-Computer Interface
chemical_list: D013662:Tea
keywords: disease; health benefit; network; phenotype; tea bioactive compound