title: Individual Differences in the Alignment of Structural and Functional Markers of the V5/MT Complex in Primates.
abstract: Extrastriate visual area V5/MT in primates is defined both structurally by myeloarchitecture and functionally by distinct responses to visual motion. Myelination is directly identifiable from postmortem histology but also indirectly by image contrast with structural magnetic resonance imaging (sMRI). First, we compared the identification of V5/MT using both sMRI and histology in Rhesus macaques. A section-by-section comparison of histological slices with in vivo and postmortem sMRI for the same block of cortical tissue showed precise correspondence in localizing heavy myelination for V5/MT and neighboring MST. Thus, sMRI in macaques accurately locates histologically defined myelin within areas known to be motion selective. Second, we investigated the functionally homologous human motion complex (hMT+) using high-resolution in vivo imaging. Humans showed considerable intersubject variability in hMT+ location, when defined with myelin-weighted sMRI signals to reveal structure. When comparing sMRI markers to functional MRI in response to moving stimuli, a region of high myelin signal was generally located within the hMT+ complex. However, there were considerable differences in the alignment of structural and functional markers between individuals. Our results suggest that variation in area identification for hMT+ based on structural and functional markers reflects individual differences in human regional brain architecture.
authors.affiliation: Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.
authors.forename: I
authors.initials: I
authors.lastname: Large
authors.affiliation: FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DU, UK.
authors.forename: H
authors.initials: H
authors.lastname: Bridge
authors.affiliation: Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.
authors.forename: B
authors.initials: B
authors.lastname: Ahmed
authors.affiliation: FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DU, UK.
authors.forename: S
authors.initials: S
authors.lastname: Clare
authors.affiliation: FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DU, UK.
authors.forename: J
authors.initials: J
authors.lastname: Kolasinski
authors.affiliation: FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DU, UK.
authors.forename: W W
authors.initials: WW
authors.lastname: Lam
authors.affiliation: FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DU, UK.
authors.forename: K L
authors.initials: KL
authors.lastname: Miller
authors.affiliation: Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, 2650 Hvidovre, Denmark.|Department of Applied Mathematics and Computer Science, Technical University of Denmark, 2800 Kongens Lyngby, Denmark.
authors.forename: T B
authors.initials: TB
authors.lastname: Dyrby
authors.affiliation: Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.
authors.forename: A J
authors.initials: AJ
authors.lastname: Parker
authors.affiliation: Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.
authors.forename: J E T
authors.initials: JET
authors.lastname: Smith
authors.affiliation: Department of Experimental Psychology, University of Oxford, Oxford, OX1 3UD, UK.
authors.forename: G
authors.initials: G
authors.lastname: Daubney
authors.affiliation: Department of Experimental Psychology, University of Oxford, Oxford, OX1 3UD, UK.
authors.forename: J
authors.initials: J
authors.lastname: Sallet
authors.affiliation: Department of Experimental Psychology, University of Oxford, Oxford, OX1 3UD, UK.|MRC Cognition and Brain Sciences Unit, Cambridge, CB2 7EF, UK.
authors.forename: A H
authors.initials: AH
authors.lastname: Bell
authors.affiliation: Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.
authors.forename: K
authors.initials: K
authors.lastname: Krug
mesh_terms: D000328:Adult; D000818:Animals; D000076103:Biological Variation, Individual; D001931:Brain Mapping; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008253:Macaca mulatta; D008279:Magnetic Resonance Imaging; D008297:Male; D009186:Myelin Sheath; D013045:Species Specificity; D014793:Visual Cortex / Q000033:anatomy & histology / Q000000981:diagnostic imaging* / Q000502:physiology*; D014795:Visual Pathways / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000502:physiology; D014796:Visual Perception / Q000502:physiology*; D055815:Young Adult
keywords: MRI; histology; monkey; myelination; visual cortex