title: Notch signaling in lung diseases: focus on Notch1 and Notch3.
abstract: Notch signaling is an evolutionarily conserved cell-cell communication mechanism that plays a key role in lung homeostasis, injury and repair. The loss of regulation of Notch signaling, especially Notch1 and Notch3, has recently been linked to the pathogenesis of important lung diseases, in particular, chronic obstructive pulmonary disease (COPD), asthma, pulmonary fibrosis, pulmonary arterial hypertension (PAH), lung cancer and lung lesions in some congenital diseases. This review focuses on recent advances related to the mechanisms and the consequences of aberrant or absent Notch1/3 activity in the initiation and progression of lung diseases. Our increasing understanding of this signaling pathway offers great hope that manipulating Notch signaling may represent a promising alternative complementary therapeutic strategy in the future.
authors.affiliation: Department of Respiratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Zong
authors.affiliation: Department of Respiratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Ruoyun
authors.initials: R
authors.lastname: Ouyang
authors.affiliation: Department of Respiratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Jinhua
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Respiratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Respiratory Medicine, The Second Xiangya Hospital of Central South University, 139 Renmin Middle Road, Changsha, Hunan 410011, People's Republic of China pingchen0731@sina.com.
authors.forename: Ping
authors.initials: P
authors.lastname: Chen
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000502:physiology; D018450:Disease Progression; D006801:Humans; D008171:Lung Diseases / Q000503:physiopathology*; D051881:Receptor, Notch1 / Q000378:metabolism*; D000071656:Receptor, Notch3 / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
chemical_list: C497761:NOTCH1 protein, human; C499374:NOTCH3 protein, human; D051881:Receptor, Notch1; D000071656:Receptor, Notch3
keywords: Notch1; Notch3; lung disease; therapy; γ-secretase