title: High circulating levels of sICAM-1 and sVCAM-1 in the patients with Hashimoto's thyroiditis.
abstract: OBJECTIVE
  To investigate whether soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) levels are increased in euthyroid patients with Hashimoto's thyroiditis (HT) and whether they are associated with thyroid autoimmunity and metabolic parameters.
  
  
  METHODS
  Cross-sectional.
  
  
  METHODS
  In total, 80 euthyroid patients with HT and 80 age- and body mass index (BMI)-matched control participants were included. Serum sICAM-1, sVCAM-1, free triiodothyronine (fT3), free thyroxine (fT4), thyroid-stimulating hormone (TSH), thyroid peroxidase antibody (anti-TPO), thyroglobulin antibody (anti-TG), fasting blood glucose (FBG), insulin, and lipid levels and homeostasis model assessment for insulin resistance (HOMA-IR) were assessed in all participants.
  
  
  RESULTS
  The patients with HT had significantly higher levels of sICAM-1 and sVCAM-1 than controls (both p < 0.001). The difference was sustained after adjustment for TSH and levothyroxine use. Regression analysis demonstrated that sICAM-1 was related to anti-TPO (p < 0.001), and sVCAM-1 was related to both anti-TPO and-TG (p < 0.001 and p = 0.03, respectively); this relationship was sustained after adjustment for age and BMI. Although FBG and HOMA-IR were higher in the HT group, logistic regression analysis revealed that there was no effect of anti-TPO, anti-TG, sICAM-1, sVCAM-1, and C-reactive protein (CRP) on the occurrence of high FBG and high HOMA-IR.
  
  
  CONCLUSIONS
  sICAM-1 and sVCAM-1 levels were significantly elevated in the patients with euthyroid HT and correlated closely with thyroid autoimmunity. However, soluble adhesion molecules had no relation with glucose metabolism parameters in the HT patients.
authors.affiliation: a Department of Endocrinology and Metabolism , Kartal Dr. Lutfi Kirdar Training and Research Hospital , Istanbul , Turkey.
authors.forename: Aysenur
authors.initials: A
authors.lastname: Ozderya
authors.affiliation: a Department of Endocrinology and Metabolism , Kartal Dr. Lutfi Kirdar Training and Research Hospital , Istanbul , Turkey.
authors.forename: Kadriye
authors.initials: K
authors.lastname: Aydin
authors.affiliation: a Department of Endocrinology and Metabolism , Kartal Dr. Lutfi Kirdar Training and Research Hospital , Istanbul , Turkey.
authors.forename: Sule
authors.initials: S
authors.lastname: Temizkan
authors.affiliation: b Department of Biochemistry, Istanbul University , Istanbul Faculty of Medicine , Istanbul , Turkey.
authors.forename: Semra
authors.initials: S
authors.lastname: Dogru Abbasoglu
authors.affiliation: b Department of Biochemistry, Istanbul University , Istanbul Faculty of Medicine , Istanbul , Turkey.
authors.forename: Pervin
authors.initials: P
authors.lastname: Vural
authors.affiliation: c Department of Endocrinology and Metabolism , Sisli Hamidiye Etfal Training and Research Hospital , Istanbul , Turkey.
authors.forename: Yuksel
authors.initials: Y
authors.lastname: Altuntas
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D050031:Hashimoto Disease / Q000097:blood*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013963:Thyroid Hormones / Q000097:blood*; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
chemical_list: D013963:Thyroid Hormones; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1
keywords: Hashimoto thyroiditis; adhesion molecules; insulin resistance