title: Association of HOMER1 rs2290639 with suicide attempts in Hong Kong Chinese and the potentially functional role of this polymorphism.
abstract: OBJECTIVE
  Animal evidence and genetic studies suggest that HOMER1 (homer homolog 1) is involved in the etiology of suicidal behavior and major depression disorder (MDD). However, most of genetic studies were performed in Caucasians and the potentially functional role of associated polymorphisms in HOMER1 was seldom reported. The purpose of this study was to investigate the association of a HOMER1 polymorphism rs2290639 with suicide attempts (SA) and MDD in Hong Kong Chinese, and then briefly elucidate the potentially functional role of the associated polymorphism.
  
  
  METHODS
  NEO personality inventory, impulsiveness and depression rating scales were completed by the subjects. The association studies of HOMER1 rs2290639 with SA or MDD were performed by case-control association studies. The bioinformatics analyses were adapted to predict potential transcription factors binding sites for the associated polymorphism.
  
  
  RESULTS
  The association studies and meta-analysis suggested that the HOMER1 rs2290639 was significantly associated with susceptibility to SA but seemed not to be associated with MDD in Hong Kong Chinese. This polymorphism might affect the transcription of the HOMER1 gene through interacting with a reliable transcription factor as found by three of four bioinformatics tools. In addition, close correlations between impulsiveness and NEO personality five factors were found in SA and MDD patients, which provide a possible way to assess the impulsiveness of patients through subjects' personality profiles for Hong Kong Chinese.
  
  
  CONCLUSIONS
  The HOMER1 rs2290639 polymorphism was significantly associated with susceptibility to SA in Hong Kong Chinese affected by psychiatric disorders, which might be explained by the potentially functional role of this polymorphism.
authors.affiliation: Croucher Laboratory for Human Genomics, Rm324A, Lo Kwee-Seong Integrated Biomedical Sciences Building, School of Biomedical Sciences, Area 39; The Nethersole School of Nursing, The Chinese University of Hong Kong, Shatin, N.T. Hong Kong.
authors.forename: Shitao
authors.initials: S
authors.lastname: Rao
authors.affiliation: Department of Psychiatry, Shatin Hospital, The Chinese University of Hong Kong, 33 Ah Kong Kok Street, Shatin, N.T. Hong Kong.
authors.forename: Marco H B
authors.initials: MH
authors.lastname: Lam
authors.affiliation: Croucher Laboratory for Human Genomics, Rm324A, Lo Kwee-Seong Integrated Biomedical Sciences Building, School of Biomedical Sciences, Area 39; The Nethersole School of Nursing, The Chinese University of Hong Kong, Shatin, N.T. Hong Kong.
authors.forename: Venus S Y
authors.initials: VS
authors.lastname: Yeung
authors.affiliation: Department of Psychiatry, Shatin Hospital, The Chinese University of Hong Kong, 33 Ah Kong Kok Street, Shatin, N.T. Hong Kong.
authors.forename: Yun Kwok
authors.initials: YK
authors.lastname: Wing
authors.affiliation: Croucher Laboratory for Human Genomics, Rm324A, Lo Kwee-Seong Integrated Biomedical Sciences Building, School of Biomedical Sciences, Area 39; The Nethersole School of Nursing, The Chinese University of Hong Kong, Shatin, N.T. Hong Kong.
authors.forename: Mary Miu Yee
authors.initials: MM
authors.lastname: Waye
keywords: Functional role; HOMER1 rs2290639; Major depression disorder; Meta-analysis; Psychometric properties; Suicidal attempts