title: Genetic perspective of retinoblastoma: From present to future.
abstract: Retinoblastoma (RB) is the most common malignant intraocular tumor in children. In the last decade, basic research has led to a better understanding of events after two hits in RB susceptibility gene (RB1), molecular mechanism of tumor growth, the cell of origin of RB, etc. This would pave way to identify biomarkers and molecular targeted therapy for better treatment option in the future. Furthermore, improvement in molecular techniques has led to enhanced diagnostic methods for early diagnosis, genetic counseling, and prevention of the disease. This review will help to understand the essence of basic research work conducted in recent times and its implication in the management of RB in the future.
authors.affiliation: Department of Genetics and Molecular Biology, Vasan Medical Research Trust, Chennai, Tamil Nadu; Dual Helix Genetic Diagnostics Private Limited, Chennai, Tamil Nadu, India.
authors.forename: Madhavan
authors.initials: M
authors.lastname: Jagadeesan
authors.affiliation: Sri Bhagavan Mahavir Vitreo-Retinal Services, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India.
authors.forename: Vikas
authors.initials: V
authors.lastname: Khetan
authors.affiliation: Narayana Nethralaya, Bengaluru, India.
authors.forename: Ashwin
authors.initials: A
authors.lastname: Mallipatna
mesh_terms: D004273:DNA, Neoplasm / Q000235:genetics*; D016161:Genes, Retinoblastoma / Q000235:genetics*; D006801:Humans; D009154:Mutation; D019572:Retinal Neoplasms / Q000175:diagnosis / Q000235:genetics*; D012175:Retinoblastoma / Q000175:diagnosis / Q000235:genetics*
chemical_list: D004273:DNA, Neoplasm