title: Neonatal Fc receptor promoter gene polymorphism does not predict pharmacokinetics of IVIg or the clinical course of GBS.
abstract: Treatment of Guillain-Barré syndrome with a standard course of high-dose intravenous immunoglobulin (IVIg) results in a variable clinical recovery which is associated with changes in serum IgG levels after treatment. The neonatal Fc-receptor protects IgG from degradation, and a genetic polymorphism in its promoter region that influences the expression of Fc-receptor, may in part explain the variation in IgG levels and outcome. This polymorphism was determined by polymerase chain reaction in a cohort of 257 patients with Guillain-Barré syndrome treated with IVIg. We could not demonstrate a relation between this polymorphism, the pharmacokinetics of IVIg, or the clinical course and outcome.
authors.affiliation: Department of Immunology Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands; Department of Neurology Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands.
authors.forename: Willem-Jan R
authors.initials: WJ
authors.lastname: Fokkink
authors.affiliation: Department of Immunology Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands; Department of Neurology Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands.
authors.forename: Annechien E G
authors.initials: AE
authors.lastname: Haarman
authors.affiliation: Department of Immunology Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands; Department of Neurology Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands.
authors.forename: Anne P
authors.initials: AP
authors.lastname: Tio-Gillen
authors.affiliation: Department of Immunology Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands; Department of Neurology Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands.
authors.forename: Wouter
authors.initials: W
authors.lastname: van Rijs
authors.affiliation: Department of Immunology Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands.
authors.forename: Ruth
authors.initials: R
authors.lastname: Huizinga
authors.affiliation: Department of Neurology Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands.
authors.forename: Pieter A
authors.initials: PA
authors.lastname: van Doorn
authors.affiliation: Department of Immunology Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands; Department of Neurology Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands.
authors.forename: Bart C
authors.initials: BC
authors.lastname: Jacobs