title: Tetramethylenedisulfotetramine: pest control gone awry.
abstract: Incidences of pesticide poisonings are a significant cause of morbidity and mortality worldwide. The seizure-inducing rodenticide tetramethylenedisulfotetramine is one of the most toxic of these agents. Although banned, it has been responsible for thousands of accidental, intentional, and mass poisonings in mainland China and elsewhere. An optimal regimen for treatment of poisoning has not been established. Its facile synthesis from easily obtained starting materials, extreme potency, and lack of odor, color, or taste make it a potential chemical threat agent. This review describes the toxicologic properties of this agent, more recent advances in our understanding of its properties, and recommendations for future research.
authors.affiliation: Department of Environmental Health Science, School of Health Sciences and Practice, Institute of Public Health, New York Medical College, Valhalla, New York. michael_shakarjian@nymc.edu.|Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York. michael_shakarjian@nymc.edu.|Department of Medicine, Division of Pulmonary and Critical Care Medicine, Rutgers-Robert Wood Johnson Medical School, Piscataway, New Jersey. michael_shakarjian@nymc.edu.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Shakarjian
authors.affiliation: Department of Environmental Health Science, School of Health Sciences and Practice, Institute of Public Health, New York Medical College, Valhalla, New York.|Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia.
authors.forename: Marcela
authors.initials: M
authors.lastname: Laukova
authors.affiliation: Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York.|Department of Obstetrics and Gynecology, New York Medical College, Valhalla, New York.|Department of Neurology, New York Medical College, Valhalla, New York.
authors.forename: Jana
authors.initials: J
authors.lastname: Velíšková
authors.affiliation: Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York.|Department of Neurology, New York Medical College, Valhalla, New York.
authors.forename: Patric K
authors.initials: PK
authors.lastname: Stanton
authors.affiliation: Department of Environmental Health Science, School of Health Sciences and Practice, Institute of Public Health, New York Medical College, Valhalla, New York.
authors.forename: Diane E
authors.initials: DE
authors.lastname: Heck
authors.affiliation: Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York.|Department of Neurology, New York Medical College, Valhalla, New York.|Department of Pediatrics, New York Medical College, Valhalla, New York.
authors.forename: Libor
authors.initials: L
authors.lastname: Velíšek
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D001952:Bridged-Ring Compounds / Q000378:metabolism / Q000506:poisoning*; D006801:Humans; D010571:Pest Control / Q000379:methods / Q000639:trends*; D011634:Public Health / Q000379:methods / Q000639:trends; D012378:Rodenticides / Q000378:metabolism / Q000506:poisoning*; D012640:Seizures / Q000139:chemically induced / Q000175:diagnosis / Q000517:prevention & control
chemical_list: D001952:Bridged-Ring Compounds; D012378:Rodenticides; C010349:tetramethylenedisulfotetramine
keywords: countermeasure; neurotoxicity; rodenticide; tetramethylenedisulfotetramine