title: Canine parvovirus: the worldwide occurrence of antigenic variants.
abstract: The most important enteric virus infecting canids is canine parvovirus type 2 (CPV-2). CPV is the aetiologic agent of a contagious disease, mainly characterized by clinical gastroenteritis signs in younger dogs. CPV-2 emerged as a new virus in the late 1970s, which could infect domestic dogs, and became distributed in the global dog population within 2 years. A few years later, the virus's original type was replaced by a new genetic and antigenic variant, called CPV-2a. Around 1984 and 2000, virus variants with the single change to Asp or Glu in the VP2 residue 426 were detected (sometimes termed CPV-2b and -2c). The genetic and antigenic changes in the variants have also been correlated with changes in their host range; in particular, in the ability to replicate in cats and also host range differences in canine and other tissue culture cells. CPV-2 variants have been circulating among wild carnivores and have been well-documented in several countries around the world. Here, we have reviewed and summarized the current information about the worldwide distribution and evolution of CPV-2 variants since they emerged, as well as the host ranges they are associated with.
authors.affiliation: Department of Veterinary Clinics, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto, 4050-313 Porto, Portugal.|Centro de Investigação em Biodiversidade e Recursos Genéticos (CIBIO), InBio, Laboratório Associado, Universidade do Porto, 4485-661 Vairão, Portugal.
authors.forename: Carla
authors.initials: C
authors.lastname: Miranda
authors.affiliation: Department of Veterinary Clinics, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto, 4050-313 Porto, Portugal.|Centro de Investigação em Biodiversidade e Recursos Genéticos (CIBIO), InBio, Laboratório Associado, Universidade do Porto, 4485-661 Vairão, Portugal.
authors.forename: Gertrude
authors.initials: G
authors.lastname: Thompson
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000032:analysis* / Q000235:genetics; D046028:Canidae; D002415:Cats; D004283:Dog Diseases / Q000453:epidemiology* / Q000821:virology*; D004285:Dogs; D019143:Evolution, Molecular; D005759:Gastroenteritis / Q000453:epidemiology / Q000662:veterinary / Q000821:virology; D014943:Global Health; D058507:Host Specificity; D010322:Parvoviridae Infections / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D017993:Parvovirus, Canine / Q000145:classification* / Q000235:genetics / Q000502:physiology; D058974:Phylogeography; D019371:Topography, Medical
chemical_list: D000956:Antigens, Viral