title: Imaging biomarkers in multiple Sclerosis: From image analysis to population imaging.
abstract: The production of imaging data in medicine increases more rapidly than the capacity of computing models to extract information from it. The grand challenges of better understanding the brain, offering better care for neurological disorders, and stimulating new drug design will not be achieved without significant advances in computational neuroscience. The road to success is to develop a new, generic, computational methodology and to confront and validate this methodology on relevant diseases with adapted computational infrastructures. This new concept sustains the need to build new research paradigms to better understand the natural history of the pathology at the early phase; to better aggregate data that will provide the most complete representation of the pathology in order to better correlate imaging with other relevant features such as clinical, biological or genetic data. In this context, one of the major challenges of neuroimaging in clinical neurosciences is to detect quantitative signs of pathological evolution as early as possible to prevent disease progression, evaluate therapeutic protocols or even better understand and model the natural history of a given neurological pathology. Many diseases encompass brain alterations often not visible on conventional MRI sequences, especially in normal appearing brain tissues (NABT). MRI has often a low specificity for differentiating between possible pathological changes which could help in discriminating between the different pathological stages or grades. The objective of medical image analysis procedures is to define new quantitative neuroimaging biomarkers to track the evolution of the pathology at different levels. This paper illustrates this issue in one acute neuro-inflammatory pathology: Multiple Sclerosis (MS). It exhibits the current medical image analysis approaches and explains how this field of research will evolve in the next decade to integrate larger scale of information at the temporal, cellular, structural and morphological levels.
authors.affiliation: CNRS, IRISA 6074, Campus de Beaulieu, F-35042 Rennes, France; Inria, Visages team, campus de Beaulieu, F-35042 Rennes, France; Inserm, Visages U746, IRISA, Campus de Beaulieu, F-35042 Rennes, France; University of Rennes I, Campus de Beaulieu, F-35042 Rennes, France. Electronic address: christian.barillot@irisa.fr.
authors.forename: Christian
authors.initials: C
authors.lastname: Barillot
authors.affiliation: CNRS, IRISA 6074, Campus de Beaulieu, F-35042 Rennes, France; Inria, Visages team, campus de Beaulieu, F-35042 Rennes, France; Inserm, Visages U746, IRISA, Campus de Beaulieu, F-35042 Rennes, France; University of Rennes I, Campus de Beaulieu, F-35042 Rennes, France; University Hospital of Rennes, Neurology Dept., rue H. Le Guilloux, F-35033 Rennes, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Edan
authors.affiliation: CNRS, IRISA 6074, Campus de Beaulieu, F-35042 Rennes, France; Inria, Visages team, campus de Beaulieu, F-35042 Rennes, France; Inserm, Visages U746, IRISA, Campus de Beaulieu, F-35042 Rennes, France; University of Rennes I, Campus de Beaulieu, F-35042 Rennes, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Commowick
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D001921:Brain / Q000378:metabolism; D003198:Computer Simulation; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000000981:diagnostic imaging* / Q000473:pathology
chemical_list: D015415:Biomarkers
keywords: Diffusion MRI; Imaging biomarkers; Medical image analysis; Mri; Multiple sclerosis; Segmentation