title: Self-Sealing Porous Silicon-Calcium Silicate Core-Shell Nanoparticles for Targeted siRNA Delivery to the Injured Brain.
abstract: Calcium ions react with silicic acid released from dissolving porous silicon nanoparticles to create an insoluble calcium silicate shell. The calcium silicate shell traps and protects an siRNA payload, which can be delivered to neuronal tissues in vitro or in vivo. Gene delivery is enhanced by the action of targeting and cell-penetrating peptides attached to the calcium silicate shell.
authors.affiliation: Department of Nanoengineering, University of California San Diego, La Jolla, CA, 92093-0358, USA.
authors.forename: Jinyoung
authors.initials: J
authors.lastname: Kang
authors.affiliation: Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, 92093-0358, USA.
authors.forename: Jinmyoung
authors.initials: J
authors.lastname: Joo
authors.affiliation: Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
authors.forename: Ester J
authors.initials: EJ
authors.lastname: Kwon
authors.affiliation: Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: Skalak
authors.affiliation: Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.
authors.forename: Sazid
authors.initials: S
authors.lastname: Hussain
authors.affiliation: Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: She
authors.affiliation: Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.|Center for Nanomedicine and Department of Molecular Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA, 93106-9610, USA.
authors.forename: Erkki
authors.initials: E
authors.lastname: Ruoslahti
authors.affiliation: Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Department of Electrical Engineering and Computer Science and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Division of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.|Howard Hughes Medical Institute, Cambridge, MA, 02139, USA.
authors.forename: Sangeeta N
authors.initials: SN
authors.lastname: Bhatia
authors.affiliation: Department of Nanoengineering, University of California San Diego, La Jolla, CA, 92093-0358, USA. msailor@ucsd.edu.|Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, 92093-0358, USA. msailor@ucsd.edu.|Department of Bioengineering, Materials Science and Engineering Program, University of California San Diego, 9500 Gilman Drive, m/c 0358, La Jolla, CA, 92093-0358, USA. msailor@ucsd.edu.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Sailor
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology; D001930:Brain Injuries / Q000378:metabolism* / Q000473:pathology; D017610:Calcium Compounds / Q000737:chemistry*; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D016062:Porosity; D034741:RNA, Small Interfering / Q000008:administration & dosage* / Q000378:metabolism / Q000493:pharmacokinetics*; D017640:Silicates / Q000737:chemistry*; D012825:Silicon / Q000737:chemistry*
chemical_list: D017610:Calcium Compounds; D034741:RNA, Small Interfering; D017640:Silicates; C031293:calcium silicate; D012825:Silicon
keywords: gene knockdowns; injured brains; photoluminescence; rabies virus glycoprotein peptides; targeted nanoparticles