title: Conditional ablation of TGF-β signaling inhibits tumor progression and invasion in an induced mouse bladder cancer model.
abstract: The role of transforming growth factor-β (TGF-β) signaling in cancer progression is still under debate. To determine the function of TGF-β signaling in bladder cancer progression, we conditionally knocked out the Tgfbr2 in mouse model after a N-butyl-N-4-hydroxybutyl Nitrosamine induced bladder carcinogenesis. We found the ablation of TGF-β signaling could inhibit the cancer cell proliferation, cancer stem cell population and EMT, hence suppressed the invasive cancer progression, which is similar with the result of TGF-β receptor I inhibitor treatment. These findings recognize the roles and mechanisms of TGF-β signaling in bladder cancer progression in vivo for the first time.
authors.affiliation: Department of biology, School of Life Science, Anhui Medical University, Hefei, Anhui 230031, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Liang
authors.affiliation: Department of biology, School of Life Science, Anhui Medical University, Hefei, Anhui 230031, China.
authors.forename: Fengyu
authors.initials: F
authors.lastname: Zhu
authors.affiliation: Department of Urology, Huadong Hospital, Fudan University. Shanghai, 200040, China.
authors.forename: Haojie
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of biology, Case western reserve university, 2080 Adelbert Road Cleveland, OH 44106, United States.
authors.forename: Demeng
authors.initials: D
authors.lastname: Chen
authors.affiliation: Department of biology, School of Life Science, Anhui Medical University, Hefei, Anhui 230031, China.
authors.forename: Xiuhong
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of biology, School of Life Science, Anhui Medical University, Hefei, Anhui 230031, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Gao
authors.affiliation: Department of biology, School of Life Science, Anhui Medical University, Hefei, Anhui 230031, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
mesh_terms: D000818:Animals; D017209:Apoptosis; D049109:Cell Proliferation; D004195:Disease Models, Animal; D018450:Disease Progression; D058750:Epithelial-Mesenchymal Transition; D020869:Gene Expression Profiling; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009361:Neoplasm Invasiveness; D014411:Neoplastic Stem Cells / Q000166:cytology; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*; D000077293:Receptor, Transforming Growth Factor-beta Type I; D018125:Receptors, Transforming Growth Factor beta / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D053773:Transforming Growth Factor beta1 / Q000235:genetics / Q000378:metabolism*; D001749:Urinary Bladder Neoplasms / Q000378:metabolism*
chemical_list: D018125:Receptors, Transforming Growth Factor beta; C508961:Tgfb1 protein, mouse; D053773:Transforming Growth Factor beta1; D017346:Protein Serine-Threonine Kinases; D000077293:Receptor, Transforming Growth Factor-beta Type I