title: Filtration markers and determination methods for the assessment of kidney function.
abstract: Estimation of renal function is crucial for a number of clinical situations. Endogenous markers such as creatinine, as well as several exogenous agents including inulin,99mTc-DTPA and iothalamate are used for evaluation of kidney function. At present, new generation filtration markers and determination methods based on organic fluorescent dyes and fluorescent detection technique are developed. This review gives an overview of filtration markers and clearance methods for the assessment of kidney function. New filtration markers and transcutaneous measurement of renal function are described. Problems and issues relating to the reabsorption or secretion of each of markers and the applicability of methods are also discussed.
authors.affiliation: Medical Research Center, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
authors.forename: Jiaguo
authors.initials: J
authors.lastname: Huang
authors.affiliation: Medical Research Center, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. Electronic address: Norbert.Gretz@medma.uni-heidelberg.de.
authors.forename: Norbert
authors.initials: N
authors.lastname: Gretz
authors.affiliation: Medical Research Center, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Weinfurter
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D005456:Fluorescent Dyes / Q000378:metabolism; D005919:Glomerular Filtration Rate; D006801:Humans; D007677:Kidney Function Tests / Q000379:methods*
chemical_list: D015415:Biomarkers; D005456:Fluorescent Dyes
keywords: Clearance methods; Filtration markers; Fluorescent markers; Glomerular filtration rate; Kidney function; Transcutaneous measurement