title: Comparative Evaluation of β-Catenin and E-Cadherin Expression in Liquid Aspiration Biopsy Specimens of Thyroid Nodules.
abstract: We compared the results of gene molecular and immunocytochemical studies of β-catenin and E-cadherin in different variants of nodular thyroid disease (nodular colloid goiter, follicular thyroid adenocarcinoma, papillary thyroid cancer) and revealed changes of the function of the E-cadherin/β-catenin complex leading to switching from adhesion function of β-catenin in nodular colloid goiter to predominantly transcriptional activity in papillary carcinoma. The results confirm the important role of disturbances in E-cadherin-β-catenin interactions in the mechanisms of malignant transformation of follicular epithelium.
authors.affiliation: Siberian State Medical University, Ministry of Health of the Russian Federation, Moscow, Russia. seneann@mail.ru.|Tomsk Research Institute of Oncology, Tomsk, Russia. seneann@mail.ru.
authors.forename: A V
authors.initials: AV
authors.lastname: Isaeva
authors.affiliation: Siberian State Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.|I. Kant Baltic Federal University, Kaliningrad, Russia.
authors.forename: A P
authors.initials: AP
authors.lastname: Zima
authors.affiliation: Siberian State Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: T V
authors.initials: TV
authors.lastname: Saprina
authors.affiliation: Russian Medical Academy of Postgraduate Education, Moscow, Russia.
authors.forename: K T
authors.initials: KT
authors.lastname: Kasoyan
authors.affiliation: Siberian State Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: O S
authors.initials: OS
authors.lastname: Popov
authors.affiliation: Moscow Municipal Oncological Hospital No. 62, Moscow, Russia.
authors.forename: O V
authors.initials: OV
authors.lastname: Brynova
authors.affiliation: Siberian State Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: I S
authors.initials: IS
authors.lastname: Berezkina
authors.affiliation: Siberian State Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Vasil'eva
authors.affiliation: V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia.|Siberian Federal University, Krasnoyarsk, Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Ryazantseva
authors.affiliation: Russian Medical Academy of Postgraduate Education, Moscow, Russia.
authors.forename: I P
authors.initials: IP
authors.lastname: Shabalova
authors.affiliation: I. Kant Baltic Federal University, Kaliningrad, Russia.
authors.forename: L S
authors.initials: LS
authors.lastname: Litvinova
authors.affiliation: Tomsk Regional Clinical Hospital, Tomsk, Russia.
authors.forename: Yu D
authors.initials: YD
authors.lastname: Pak
authors.affiliation: Siberian State Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Novitskii
mesh_terms: D000236:Adenoma / Q000175:diagnosis / Q000378:metabolism; D015703:Antigens, CD; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D044963:Biopsy, Fine-Needle; D015820:Cadherins / Q000235:genetics / Q000378:metabolism*; D002291:Carcinoma, Papillary / Q000175:diagnosis / Q000378:metabolism*; D015870:Gene Expression; D006044:Goiter, Nodular / Q000175:diagnosis / Q000378:metabolism; D006801:Humans; D013961:Thyroid Gland / Q000378:metabolism / Q000473:pathology; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D051176:beta Catenin / Q000235:genetics / Q000378:metabolism*
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; C513384:CDH1 protein, human; C495270:CTNNB1 protein, human; D015820:Cadherins; D051176:beta Catenin
keywords: E-cadherin; thyroid cancer; β-catenin