title: Effects of N-[Imino(1-Piperidinyl)Methyl] Guanidine on the Intensity of Free Radical Processes, Aconitase Activity, and Citrate Level in the Tissues of Rats with Experimental Type 2 Diabetes Mellitus.
abstract: Effects of a synthetic biguanide derivative N-[imino(1-piperidinyl)methyl] guanidine (NIPMG) on free radical homeostasis, aconitase activity, and citrate concentration were studied in the liver and blood serum of rats with type 2 diabetes mellitus. Analysis of biochemiluminescence parameters showed that administration of this agent (10 mg/kg body weight) to animals with diabetes reduced the intensity of free radical processes in study tissues relative to the increased values in untreated diabetic animals. Under these conditions, aconitase activity, a principal target of ROS effects, and citrate level in the liver and blood serum of rats approached the control levels. The results show that NIPMG can positively regulate free radical homeostasis and reduce the intensity of oxidative stress in type 2 diabetes mellitus, which was accompanied by normalization of the studied parameters.
authors.affiliation: Voronezh State University, Voronezh, Russia. katttilda@mail.ru.
authors.forename: E I
authors.initials: EI
authors.lastname: Skliarova
authors.affiliation: Voronezh State University, Voronezh, Russia.
authors.forename: T N
authors.initials: TN
authors.lastname: Popova
authors.affiliation: Voronezh State University, Voronezh, Russia.
authors.forename: K K
authors.initials: KK
authors.lastname: Shulgin
mesh_terms: D000154:Aconitate Hydratase / Q000378:metabolism*; D000818:Animals; D002951:Citrates / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D004353:Drug Evaluation, Preclinical; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism; D008297:Male; D008760:Methylguanidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D002951:Citrates; D007004:Hypoglycemic Agents; C573673:N-(imino(1-piperidinyl)methyl)guanidine; D010880:Piperidines; D017382:Reactive Oxygen Species; D008760:Methylguanidine; D000154:Aconitate Hydratase
keywords: N-[imino(1-piperidinyl)methyl] guanidine; aconitase; citrate; free radical oxidation; type 2 diabetes mellitus