title: Role of hepatic macrophages in alcoholic liver disease.
abstract: Alcohol consumption can lead to the increase in gut permeability and cause the translocation of bacteria-derived lipopolysaccharides from the gut to the liver, which subsequently activates immune responses. In this process, macrophages play a critical role and involve in the pathogenesis of alcoholic liver disease (ALD). To define the mechanism underpinning the function of macrophages, it is important to conduct extensive studies to further explicate the phenotypic diversity of macrophages in the context of ALD. In this review, the role of hepatic macrophages in the pathogenesis of ALD is discussed.
authors.affiliation: Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Denver, Colorado, USA.
authors.forename: Cynthia
authors.initials: C
authors.lastname: Ju
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA Roudebush Veterans Administration Medical Center, Indianapolis, Indiana, USA.
authors.forename: Suthat
authors.initials: S
authors.lastname: Liangpunsakul
mesh_terms: D000818:Animals; D006801:Humans; D008099:Liver / Q000473:pathology*; D008108:Liver Diseases, Alcoholic / Q000473:pathology*; D008264:Macrophages / Q000473:pathology*; D009000:Monocytes / Q000473:pathology
keywords: Liver Diseases, Alcoholic; Macrophages