title: Forensic Spanish allele and haplotype database for a 17 X-STR panel.
abstract: The currently developed 17 X-STR panel (DXS8378, DXS9898, DXS7133, GATA31E08, GATA172D05, DXS6801, DXS7423, DXS6809, DXS6799, DXS7132, DXS9902, DXS6800, DXS6789, DXS10075, DXS10079, DXS6807, and DXS6803) offers a highly discriminative tool for forensic identification and kinship testing. With the aim of providing a global Spanish population X-STR database, we present haplotype and allele frequencies and parameters of forensic interest for the 17 X-STR panel obtained from 593 unrelated individuals from Alicante, Aragon, the Basque Country, Andalusia, Galicia, Madrid, and Barcelona that represent the most populated regions of the Spanish Peninsular territory. The seven populations were compared to test possible population genetic substructures. The lack of significant differences among the studied Spanish populations supports the use of the allele and haplotype frequency database presented herein as a global Spanish population sample useful for statistical evaluation in forensic casework. After conducting the LD plots derived from HapMap and pairwise linkage disequilibrium tests, DXS7132, DXS10075, and DXS10079 markers were included in a cluster and haplotype frequencies were calculated. The improvement in the forensic parameters for the Spanish population using 17 X-STRs in comparison to the previous 10 X-STR allele frequencies database is also shown.
authors.affiliation: BIOMICs Research Group, Lascaray Research Center, University of the Basque Country UPV/EHU. Avda. Miguel de Unamuno, 3. 01006 Vitoria-Gasteiz, Spain.
authors.forename: Endika
authors.initials: E
authors.lastname: Prieto-Fernández
authors.affiliation: BIOMICs Research Group, Lascaray Research Center, University of the Basque Country UPV/EHU. Avda. Miguel de Unamuno, 3. 01006 Vitoria-Gasteiz, Spain.
authors.forename: Carolina
authors.initials: C
authors.lastname: Núñez
authors.affiliation: BIOMICs Research Group, Lascaray Research Center, University of the Basque Country UPV/EHU. Avda. Miguel de Unamuno, 3. 01006 Vitoria-Gasteiz, Spain.
authors.forename: Miriam
authors.initials: M
authors.lastname: Baeta
authors.affiliation: Área Medicina Legal y Forense, Dpto. Patología y Cirugía, Universidad Miguel Hernández de Elche, Elche, Alicante, Spain.
authors.forename: Susana
authors.initials: S
authors.lastname: Jiménez-Moreno
authors.affiliation: Department of Forensic Medicine, University of Zaragoza, Zaragoza, Spain.
authors.forename: Begoña
authors.initials: B
authors.lastname: Martínez-Jarreta
authors.affiliation: BIOMICs Research Group, Lascaray Research Center, University of the Basque Country UPV/EHU. Avda. Miguel de Unamuno, 3. 01006 Vitoria-Gasteiz, Spain. Electronic address: marian.mdepancorbo@ehu.es.
authors.forename: Marian M
authors.initials: MM
authors.lastname: de Pancorbo
mesh_terms: D041321:Chromosomes, Human, X; D016172:DNA Fingerprinting; D030561:Databases, Nucleic Acid; D005260:Female; D005787:Gene Frequency; D005828:Genetics, Population; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D018895:Microsatellite Repeats; D013030:Spain
keywords: 17 X-STRs; Database; Forensic; Haplotype; Linkage disequilibrium