title: Efficient Route to Deuterated Aromatics by the Deamination of Anilines.
abstract: One-step replacement of NH2 groups in ring-substituted anilines by deuterium is reported. Approaches comprising both solid-phase and solution-phase syntheses can be used on a large variety of substrates. The method uses diazotization in a mixture of water and either dichloromethane or chloroform, which serve as a source of hydrogen. This protocol can be used as a general method for fast and easy incorporation of deuterium into an aromatic system using deuterated chloroform.
authors.affiliation: Institute of Molecular and Translation Medicine, Faculty of Medicine, Palacký University , Hněvotínská 5, 779 00 Olomouc, Czech Republic.
authors.forename: Kristyna
authors.initials: K
authors.lastname: Burglova
authors.affiliation: Department of Organic Chemistry, Faculty of Science, Palacký University , 771 46 Olomouc, Czech Republic.
authors.forename: Sergei
authors.initials: S
authors.lastname: Okorochenkov
authors.affiliation: Department of Organic Chemistry, Faculty of Science, Palacký University , 771 46 Olomouc, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Hlavac