title: Post-operative ovarian adhesion formation after ovarian drilling: a randomized study comparing conventional laparoscopy and transvaginal hydrolaparoscopy.
abstract: To compare conventional laparoscopic ovarian drilling (LOD) with transvaginal hydrolaparoscopy (THL) ovarian drilling in terms of ovarian adhesion formation, evaluated using office THL during follow-up in CC-resistant anovulatory patients affected by PCOS.
  
  
  
  Prospective randomized study on 246 CC-resistant women with PCOS. The patients enrolled were divided into two groups, 123 were scheduled to undergo LOD and 123 to undergo THL ovarian drilling. Six months after the procedure all patients were offered office transvaginal hydrolaparoscopy (THL) follow-up, under local anesthesia to evaluate adhesion formation.
  
  
  
  Duration of the procedure was significantly shorter in the THL group in comparison with LOD group (p < 0.0001). No intra- or post-operative complication was observed in any of the patients in both groups. Post-operative THL follow-up after 6 months showed that 15 (15.5 %) patients in the THL group and 73 (70.2 %) in the LOD group showed the presence of ovarian adhesion. This difference was highly significant with a p value <0.0001 and a relative risk of 0.22 [95 % IC 0.133-0.350].
  
  
  
  This study seems to indicate that THL ovarian drilling may reduce the risk of ovarian adhesion formation and could be used as a safe and effective option to reduce ovarian adhesion formation in patients undergoing ovarian drilling.
authors.affiliation: Department of Obstetrics, Gynecology, and Urology, University of Naples "Federico II", Via Pansini 5, Naples, Italy. pgiampaolino@gmail.com.
authors.forename: Pierluigi
authors.identifier: 0000-0001-8587-3780
authors.initials: P
authors.lastname: Giampaolino
authors.affiliation: Department of Obstetrics, Gynecology, and Urology, University of Naples "Federico II", Via Pansini 5, Naples, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Morra
authors.affiliation: Department of Obstetrics, Gynecology, and Urology, University of Naples "Federico II", Via Pansini 5, Naples, Italy.
authors.forename: Giovanni Antonio
authors.initials: GA
authors.lastname: Tommaselli
authors.affiliation: Department of Obstetrics, Gynecology, and Urology, University of Naples "Federico II", Via Pansini 5, Naples, Italy.
authors.forename: Costantino
authors.initials: C
authors.lastname: Di Carlo
authors.affiliation: Department of Public Health, University of Naples "Federico II", Naples, Italy.
authors.forename: Carmine
authors.initials: C
authors.lastname: Nappi
authors.affiliation: Department of Obstetrics, Gynecology, and Urology, University of Naples "Federico II", Via Pansini 5, Naples, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Bifulco
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D057605:Natural Orifice Endoscopic Surgery / Q000379:methods*; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000601:surgery*; D011183:Postoperative Complications; D011446:Prospective Studies; D000267:Tissue Adhesions / Q000209:etiology*; D014621:Vagina / Q000601:surgery*
keywords: Office transvaginal hydrolaparoscopy; Ovarian drilling; PCOS; Post-operative ovarian adhesions