title: Evolution of the Antidepressant Prescribing in Alzheimer's Disease and Related Disorders Between 2010 and 2014: Results from the French National Database on Alzheimer's Disease (BNA).
abstract: Safety warnings from health authorities are currently intended to limit the use of psychotropic agents in dementia-related conditions. Evidence concerning the use of antidepressants in dementia is, however, scarce and contradictory.
  
  
  
  To evaluate antidepressant use among individuals with Alzheimer's disease (AD) and related disorders in the French population between 2010 and 2014.
  
  
  
  Antidepressant prescriptions in individuals with AD, mixed dementia (MD), and vascular dementia (VaD) in the French National Alzheimer Database between 2010 and 2014 were analyzed (N = 199,544).
  
  
  
  Multivariate analysis showed an annual significant increase (p < 0.001) in the prescription rate of antidepressants from 26% (2010) to 31% (2014), and identified female gender, younger age, higher education, living in long-term facilities, more severe cognitive decline, and presence of vascular signs (VaD and MD) as associated factors for antidepressant prescribing.
  
  
  
  The annual increase of antidepressant prescribing among individuals with AD, MD, and VaD in French specialized settings may be partially related to the lack of current valuable medications for dementia-related behavioral symptoms.
authors.affiliation: EA Cobtek, University of Nice Sophia-Antipolis, Nice, France.|Research Memory Centre, Nice University Hospital, Nice, France.
authors.forename: Renaud
authors.initials: R
authors.lastname: David
authors.affiliation: EA Cobtek, University of Nice Sophia-Antipolis, Nice, France.
authors.forename: Valeria
authors.initials: V
authors.lastname: Manera
authors.affiliation: EA Cobtek, University of Nice Sophia-Antipolis, Nice, France.|Department of Public Health, L'Archet Hospital, Nice University Hospital, Nice, France.
authors.forename: Roxane
authors.initials: R
authors.lastname: Fabre
authors.affiliation: Department of Public Health, L'Archet Hospital, Nice University Hospital, Nice, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Pradier
authors.affiliation: EA Cobtek, University of Nice Sophia-Antipolis, Nice, France.|Research Memory Centre, Nice University Hospital, Nice, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Robert
authors.affiliation: EA Cobtek, University of Nice Sophia-Antipolis, Nice, France.|Department of Public Health, L'Archet Hospital, Nice University Hospital, Nice, France.
authors.forename: Karim
authors.initials: K
authors.lastname: Tifratene
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000928:Antidepressive Agents / Q000627:therapeutic use*; D002561:Cerebrovascular Disorders / Q000188:drug therapy / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003704:Dementia / Q000188:drug therapy* / Q000453:epidemiology; D004522:Educational Status; D005260:Female; D005602:France; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D010818:Practice Patterns, Physicians' / Q000639:trends; D015995:Prevalence; D012112:Residential Facilities; D012720:Severity of Illness Index; D012737:Sex Factors
chemical_list: D000928:Antidepressive Agents
keywords: Alzheimer’s disease; antidepressant; dementia; psychotropic medication