title: Phosphate bioisostere containing amphiphiles: a novel class of squaramide-based lipids.
abstract: We describe a novel class of amphiphiles with squaramide moiety as a phosphate bioisostere. Most synthesized squaramide-based amphiphiles have the favorable physicochemical properties of lipids, such as: formation of stable liposomes or giant unilamellar vesicles in aqueous solution, high phase-transition temperature, low vesicle leakage and phospholipase resistance properties.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Guwahati, Assam 781039, India. dmanna@iitg.ernet.in.
authors.forename: Abhishek
authors.initials: A
authors.lastname: Saha
authors.affiliation: Department of Chemistry, Indian Institute of Technology Guwahati, Assam 781039, India. dmanna@iitg.ernet.in.
authors.forename: Subhankar
authors.initials: S
authors.lastname: Panda
authors.affiliation: Department of Chemistry, Indian Institute of Technology Guwahati, Assam 781039, India. dmanna@iitg.ernet.in.
authors.forename: Saurav
authors.initials: S
authors.lastname: Paul
authors.affiliation: Department of Chemistry, Indian Institute of Technology Guwahati, Assam 781039, India. dmanna@iitg.ernet.in.
authors.forename: Debasis
authors.initials: D
authors.lastname: Manna
mesh_terms: D008055:Lipids / Q000737:chemistry*; D015394:Molecular Structure; D010316:Particle Size; D010710:Phosphates / Q000737:chemistry*; D011803:Quinine / Q000031:analogs & derivatives* / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry*; D013696:Temperature
chemical_list: D008055:Lipids; D010710:Phosphates; D013501:Surface-Active Agents; C000609819:squaramide; D011803:Quinine