title: Intestinal methane production is associated with decreased weight loss following bariatric surgery.
abstract: To determine whether methane and hydrogen on breath test affects weight loss after bariatric surgery, 156 subjects (pre-surgery BMI ≥33) were recruited ≥4 months after surgery. Pre- and post-surgery weights and BMIs were recorded. Post-surgery methane and hydrogen levels were determined. % total weight loss and % change in BMI were prorated to six months after surgery. M+/H+ subjects (N=13) exhibited lower prorated % change in BMI vs. all other subjects (N=144) (p=0.13), and significantly lower prorated % total weight loss (p=0.036). These findings may suggest that subjects with positive breath methane and hydrogen lose less weight following bariatric surgery.
authors.affiliation: Division of Endocrine Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA, United States. Electronic address: ruchi.mathur@cshs.org.
authors.forename: Ruchi
authors.initials: R
authors.lastname: Mathur
authors.affiliation: Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN, United States.
authors.forename: Manpreet S
authors.initials: MS
authors.lastname: Mundi
authors.affiliation: GI Motility Program, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
authors.forename: Kathleen S
authors.initials: KS
authors.lastname: Chua
authors.affiliation: Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN, United States.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Lorentz
authors.affiliation: GI Motility Program, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
authors.forename: Gillian M
authors.initials: GM
authors.lastname: Barlow
authors.affiliation: GI Motility Program, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
authors.forename: Eugenia
authors.initials: E
authors.lastname: Lin
authors.affiliation: Center for Weight Loss, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
authors.forename: Miguel
authors.initials: M
authors.lastname: Burch
authors.affiliation: Center for Weight Loss, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
authors.forename: Adrienne
authors.initials: A
authors.lastname: Youdim
authors.affiliation: GI Motility Program, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
authors.forename: Mark
authors.initials: M
authors.lastname: Pimentel
mesh_terms: D000328:Adult; D050110:Bariatric Surgery; D015992:Body Mass Index; D001944:Breath Tests; D005260:Female; D000069196:Gastrointestinal Microbiome; D006801:Humans; D006859:Hydrogen / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000382:microbiology; D008297:Male; D008697:Methane / Q000378:metabolism*; D008875:Middle Aged; D009767:Obesity, Morbid / Q000378:metabolism* / Q000601:surgery; D015431:Weight Loss
chemical_list: D006859:Hydrogen; D008697:Methane
keywords: Bariatric surgery; Breath test; Methane; Methanogen