title: Soft Tissue Response to Titanium Abutments with Different Surface Treatment: Preliminary Histologic Report of a Randomized Controlled Trial.
abstract: The aim of this preliminary prospective RCT was to histologically evaluate peri-implant soft tissues around titanium abutments treated using different cleaning methods. Sixteen patients were randomized into three groups: laboratory customized abutments underwent Plasma of Argon treatment (Plasma Group), laboratory customized abutments underwent cleaning by steam (Steam Group), and abutments were used as they came from industry (Control Group). Seven days after the second surgery, soft tissues around abutments were harvested. Samples were histologically analyzed. Soft tissues surrounding Plasma Group abutments predominantly showed diffuse chronic infiltrate, almost no acute infiltrate, with presence of few polymorphonuclear neutrophil granulocytes, and a diffuse presence of collagenization bands. Similarly, in Steam Group, the histological analysis showed a high variability of inflammatory expression factors. Tissues harvested from Control Group showed presence of few neutrophil granulocytes, moderate presence of lymphocytes, and diffuse collagenization bands in some sections, while they showed absence of acute infiltrate in 40% of sections. However, no statistical difference was found among the tested groups for each parameter (p > 0.05). Within the limit of the present study, results showed no statistically significant difference concerning inflammation and healing tendency between test and control groups.
authors.affiliation: Private Practice, 00198 Rome, Italy; Department of Oral Surgery, University of Valencia, 46700 Valencia, Spain.
authors.forename: Luigi
authors.initials: L
authors.lastname: Canullo
authors.affiliation: Department of Oral Surgery, Goethe-Universität Frankfurt am Main, 60311 Frankfurt, Germany.
authors.forename: Jan Friedrich
authors.initials: JF
authors.lastname: Dehner
authors.affiliation: Department of Oral Surgery, University of Valencia, 46700 Valencia, Spain.
authors.forename: David
authors.initials: D
authors.lastname: Penarrocha
authors.affiliation: Department of Medical Sciences, University of Trieste, 34129 Trieste, Italy.
authors.forename: Vittorio
authors.initials: V
authors.lastname: Checchi
authors.affiliation: Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, 40100 Bologna, Italy.
authors.forename: Annalisa
authors.initials: A
authors.lastname: Mazzoni
authors.affiliation: Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, 40100 Bologna, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Breschi
mesh_terms: D003094:Collagen / Q000378:metabolism; D000044:Dental Abutments; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009055:Mouth / Q000187:drug effects / Q000473:pathology*; D058626:Plasma Gases / Q000494:pharmacology; D014025:Titanium / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects
chemical_list: D058626:Plasma Gases; D003094:Collagen; D014025:Titanium