title: Maintenance of the adult Drosophila intestine: all roads lead to homeostasis.
abstract: Maintenance of tissue homeostasis is critical in tissues with high turnover such as the intestinal epithelium. The intestinal epithelium is under constant cellular assault due to its digestive functions and its function as a barrier to chemical and bacterial insults. The resulting high rate of cellular turnover necessitates highly controlled mechanisms of regeneration to maintain the integrity of the tissue over the lifetime of the organism. Transient increase in stem cell proliferation is a commonly used and elaborate mechanism to ensure fast and efficient repair of the gut. However, tissue repair is not limited to regulating ISC proliferation, as emerging evidence demonstrates that the Drosophila intestine uses multiple strategies to ensure proper tissue homeostasis that may also extend to other tissues.
authors.affiliation: Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Guo
authors.affiliation: Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA.
authors.forename: Elena
authors.initials: E
authors.lastname: Lucchetta
authors.affiliation: Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA.
authors.forename: Neus
authors.initials: N
authors.lastname: Rafel
authors.affiliation: Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA. Electronic address: bo2160@cumc.columbia.edu.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Ohlstein
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000235:genetics; D004331:Drosophila melanogaster / Q000235:genetics / Q000254:growth & development; D006706:Homeostasis / Q000235:genetics*; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000254:growth & development*; D012038:Regeneration / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics; D013234:Stem Cells