title: The Role of Hyperglycemia and Insulin Resistance in the Development and Progression of Pulmonary Arterial Hypertension.
abstract: Pulmonary hypertension is a progressive disorder which often leads to right ventricular failure and death. While the existing classification system for pulmonary hypertension does not account for the impact of diabetes mellitus, evidence is emerging that suggests that diabetes is associated with pulmonary hypertension and that diabetes modifies the course of pulmonary hypertension. There is also growing radiographic, hemodynamic, biochemical, and pathologic data supporting an association between diabetes and pulmonary hypertension. More robust epidemiologic studies are needed to confirm an association between diabetes and pulmonary hypertension and to show that diabetes is a disease modifier in pulmonary hypertension. In addition, evaluating the effects of glucose control in animals with pulmonary hypertension and diabetes (as well as in humans) is warranted.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Virginia Commonwealth University Health System, Richmond, VA 23298, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Grinnan
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Virginia Commonwealth University Health System, Richmond, VA 23298, USA.
authors.forename: Grant
authors.initials: G
authors.lastname: Farr
authors.affiliation: Department of Internal Medicine, Virginia Commonwealth University Health System, Richmond, VA 23298, USA.
authors.forename: Adam
authors.initials: A
authors.lastname: Fox
authors.affiliation: Division of Endocrinology, Virginia Commonwealth University Health System, Richmond, VA 23298, USA.
authors.forename: Lori
authors.initials: L
authors.lastname: Sweeney
mesh_terms: D003920:Diabetes Mellitus / Q000453:epidemiology / Q000378:metabolism* / Q000503:physiopathology; D018450:Disease Progression; D018149:Glucose Intolerance / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D006943:Hyperglycemia / Q000378:metabolism* / Q000503:physiopathology; D006976:Hypertension, Pulmonary / Q000453:epidemiology / Q000378:metabolism* / Q000503:physiopathology; D007333:Insulin Resistance; D055806:Microvessels / Q000378:metabolism / Q000503:physiopathology; D011652:Pulmonary Circulation; D018497:Ventricular Dysfunction, Right / Q000378:metabolism* / Q000503:physiopathology