title: Malignancy risk of oncocytic changes in thyroid nodules: who should we offer surgery to?
abstract: Background Oncocytic (Hürthle) cell in fine-needle aspiration biopsy (FNAB) remains challenging for surgeons. Surgical treatment is recommended for oncocytic change in FNAB, since it can sometimes be a struggle to determine the nature of thyroid nodules. We aimed to investigate the clinical significance of oncocytic changes in FNAB in terms of management of patients. Methods The FNAB samples of 172 patients with thyroid nodules were reviewed. Of these, 39 patients with cytologic findings of oncocytic changes on FNAB [POC: predominance of oncocytic cells; SFON-H: suspicious for follicular or oncocytic neoplasm (Hürthle cell type), SM-O: suspicious for malignancy-papillary or follicular carcinoma; oncocytic variant)] were included. Results FNAB demonstrated POC in 14 (35.8%), SFON-H in 15 (38.4%), and SM-O in 10 (25.6%) patients. The overall malignancy rate was 35.8% (n = 14). Clinical and laboratory data were not found to be associated with thyroid cancer while nodule size was significantly higher in patients with thyroid malignancy (15.2 versus 23.3 mm, p = 0.032). Regarding FNAB results including oncocytic changes, the rate of malignancy was significantly different and almost three-fold higher in nodules classified as SFON-H and SM-O [48% versus 14.2% with POC, p = 0.044]. Besides, there was a positive correlation between SFON-H and SM-O cytology and malignancy (p = 0.036, r = 0.337). Conclusions It is hard to discern the significance of oncocytic changes in FNAB report and to determine an optimal approach as a surgeon. We recommend surgery for the patients with an FNAB showing SFON-H and SM-O whereas POC should be better to be followed-up.
authors.affiliation: a Department of General Surgery , Sisli Etfal Training and Research Hospital , Istanbul , Turkey ;
authors.forename: Pinar
authors.initials: P
authors.lastname: Yazici
authors.affiliation: b Department of Pathology , Sisli Etfal Training and Research Hospital , Istanbul , Turkey.
authors.forename: Banu
authors.initials: B
authors.lastname: Yilmaz
authors.affiliation: a Department of General Surgery , Sisli Etfal Training and Research Hospital , Istanbul , Turkey ;
authors.forename: Emre
authors.initials: E
authors.lastname: Bozkurt
authors.affiliation: a Department of General Surgery , Sisli Etfal Training and Research Hospital , Istanbul , Turkey ;
authors.forename: Mehmet
authors.initials: M
authors.lastname: Mihmanli
authors.affiliation: a Department of General Surgery , Sisli Etfal Training and Research Hospital , Istanbul , Turkey ;
authors.forename: Mehmet
authors.initials: M
authors.lastname: Uludag
mesh_terms: D000328:Adult; D044963:Biopsy, Fine-Needle / Q000379:methods; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D016208:Databases, Factual; D003657:Decision Making; D055088:Early Detection of Cancer / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018570:Risk Assessment; D018709:Statistics, Nonparametric; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000601:surgery*; D016606:Thyroid Nodule / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery*; D013965:Thyroidectomy / Q000379:methods
keywords: Thyroid nodule; fine-needle aspiration biopsy; oncocytic changes; surgical treatment