title: S-Nitrosothiols-NO donors regulating cardiovascular cell proliferation: Insight into intracellular pathway alterations.
abstract: Nitric oxide (NO) produced by endothelial nitric oxide synthase (eNOS) activates signaling pathways responsible for smooth muscle cell relaxation, leading to vasodilation and thus plays an important role in controlling vascular homeostasis, thrombosis and inflammation. Recent studies indicate that S-nitrosothiols produced in vivo as well as synthetic ones might be important reservoirs of NO. Based on a broad range of NO functions within the living organisms, this review highlights the impact of S-nitrosothiols on cardiovascular cell cycle. The cell membrane transport and the decomposition patterns responsible of S-nitrosothiols actions are presented. The effects of NO delivery through S-nitrosothiols have a significant potential in cardiovascular diseases with various underlying causes. The challenges related to their application in the pharmacotherapy of patients with various cardiovascular diseases are also discussed.
authors.affiliation: Department of Pharmaceutical Technology, Faculty of Pharmacy, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznan, Poland.
authors.forename: Marek
authors.initials: M
authors.lastname: Rychter
authors.affiliation: Université de Lorraine, CITHEFOR EA3452 "Drug Targets, Formulation and Preclinical Assessment", Faculté de Pharmacie, 5, rue A. Lebrun, F-54000 Nancy, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Gaucher
authors.affiliation: Université de Lorraine, CITHEFOR EA3452 "Drug Targets, Formulation and Preclinical Assessment", Faculté de Pharmacie, 5, rue A. Lebrun, F-54000 Nancy, France.
authors.forename: Ariane
authors.initials: A
authors.lastname: Boudier
authors.affiliation: Université de Lorraine, CITHEFOR EA3452 "Drug Targets, Formulation and Preclinical Assessment", Faculté de Pharmacie, 5, rue A. Lebrun, F-54000 Nancy, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Leroy
authors.affiliation: Department of Pharmaceutical Technology, Faculty of Pharmacy, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznan, Poland. Electronic address: jlulek@ump.edu.pl.
authors.forename: Janina
authors.initials: J
authors.lastname: Lulek
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000473:pathology; D002319:Cardiovascular System / Q000166:cytology* / Q000187:drug effects / Q000473:pathology; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D042541:Intracellular Space / Q000187:drug effects* / Q000378:metabolism*; D020030:Nitric Oxide Donors / Q000494:pharmacology* / Q000627:therapeutic use; D026403:S-Nitrosothiols / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D020030:Nitric Oxide Donors; D026403:S-Nitrosothiols
keywords: Cell proliferation; Nitric oxide; S-Glutathionylation; S-Nitrosation; S-Nitrosothiols