title: Impact of type 2 diabetes mellitus on recurrent myocardial infarction in China.
abstract: To evaluate the influence of type 2 diabetes mellitus on the long-term outcomes of Chinese patients with previous myocardial infarction, we studied 864 patients with previous myocardial infarction, including 251 with type 2 diabetes mellitus and 613 without type 2 diabetes mellitus, over a median follow-up time of 2.9 years. The type 2 diabetes mellitus patients were subdivided into 95 insulin-treated diabetes mellitus and 156 non-insulin-treated diabetes mellitus subjects. The crude incidences (per 1000 patient-years) in the type 2 diabetes mellitus subjects versus the non-type 2 diabetes mellitus subjects were 43.7 versus 25.1 for recurrent myocardial infarction, 68.7 versus 28.3 for all-cause death and 99.8 versus 49.9 for the composite end point (i.e. recurrent myocardial infarction or all-cause death). Cox regression analysis showed that the adjusted hazard ratios for recurrent myocardial infarction, all-cause death and their combination were 1.67 (95% confidence interval: 1.06-2.74), 1.90 (1.25-2.90) and 1.72 (1.23-2.40), respectively. Significant associations were also observed between insulin treatment and all-cause death. Our findings suggested that type 2 diabetes mellitus is an independent risk factor for recurrent myocardial infarction, all-cause death and the composite end point among previous myocardial infarction patients.
authors.affiliation: Department of Cardiology, Zhengzhou University People's Hospital, Zhengzhou, China.
authors.forename: Wentao
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Cardiology, Zhengzhou University People's Hospital, Zhengzhou, China.
authors.forename: Muwei
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Cardiology, Zhengzhou University People's Hospital, Zhengzhou, China gaocy6804@163.com.
authors.forename: Chuanyu
authors.initials: C
authors.lastname: Gao
authors.affiliation: Department of Cardiology, Zhengzhou University People's Hospital, Zhengzhou, China.
authors.forename: Xianpei
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Zhengzhou University People's Hospital, Zhengzhou, China.
authors.forename: Datun
authors.initials: D
authors.lastname: Qi
authors.affiliation: Department of Cardiology, Zhengzhou University People's Hospital, Zhengzhou, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Qiangsong
authors.initials: Q
authors.lastname: Jin
mesh_terms: D000368:Aged; D002423:Cause of Death; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology* / Q000401:mortality; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality; D016016:Proportional Hazards Models; D012008:Recurrence; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin
keywords: Type 2 diabetes mellitus; insulin; myocardial infarction; prognosis