title: Is an iris claw IOL a good option for correcting surgically induced aphakia in children? A review of the literature and illustrative case study.
abstract: Refractive correction of aphakia in childhood can be a complex management issue following lensectomy for congenital cataract or ectopia lentis. Some children have inadequate capsular support to allow an 'in the bag' or sulcus fixated intra-ocular lens (IOL). In such cases, options for refractive correction include spectacles, contact lenses, or surgically fixed IOLs. Many methods of IOL fixation have been described, but none are widely adopted in children. In recent years, the iris-fixated Artisan Aphakic IOL has gained popularity, but there is still significant concern about the rate of corneal endothelial cell loss and IOL de-enclavation. Here, we review the current literature on the use of iris-fixated IOLs in children, the published data on endothelial cell loss and de-enclavation rates. We present a case illustrating the significant improvements in quality of life, which can be seen in selected children, and also the rate of endothelial cell loss, which can be encountered after initial surgery, and a re-enclavation event. We make the case that until more data are available on normal endothelial cell decline in early childhood, in addition to age-specific rates of endothelial cell loss and de-enclavation rates following surgery, the use of iris-fixated IOLs in children will continue to be a moot point and is unlikely to be widely adopted.
authors.affiliation: Southampton Eye Unit, University Hospital Southampton, Southampton, UK.
authors.forename: R
authors.initials: R
authors.lastname: Barbara
authors.affiliation: Southampton Eye Unit, University Hospital Southampton, Southampton, UK.|Faculty of Medicine, University of Southampton, Southampton, UK.
authors.forename: S R
authors.initials: SR
authors.lastname: Rufai
authors.affiliation: Faculty of Medicine, University of Southampton, Southampton, UK.
authors.forename: N
authors.initials: N
authors.lastname: Tan
authors.affiliation: Southampton Eye Unit, University Hospital Southampton, Southampton, UK.|Faculty of Medicine, University of Southampton, Southampton, UK.
authors.forename: J E
authors.initials: JE
authors.lastname: Self
mesh_terms: D001036:Aphakia, Postcataract / Q000209:etiology / Q000534:rehabilitation*; D002387:Cataract Extraction / Q000379:methods*; D002452:Cell Count; D002675:Child, Preschool; D055954:Corneal Endothelial Cell Loss / Q000175:diagnosis / Q000209:etiology; D004479:Ectopia Lentis / Q000601:surgery*; D004728:Endothelium, Corneal / Q000473:pathology; D006801:Humans; D007498:Iris / Q000601:surgery*; D019654:Lens Implantation, Intraocular / Q000379:methods*; D007908:Lens, Crystalline / Q000601:surgery*; D007910:Lenses, Intraocular; D008297:Male; D011474:Prosthesis Design; D011788:Quality of Life; D012029:Refraction, Ocular; D014792:Visual Acuity / Q000502:physiology