title: Mechanisms of ATP-Dependent Chromatin Remodeling Motors.
abstract: Chromatin remodeling motors play essential roles in all DNA-based processes. These motors catalyze diverse outcomes ranging from sliding the smallest units of chromatin, known as nucleosomes, to completely disassembling chromatin. The broad range of actions carried out by these motors on the complex template presented by chromatin raises many stimulating mechanistic questions. Other well-studied nucleic acid motors provide examples of the depth of mechanistic understanding that is achievable from detailed biophysical studies. We use these studies as a guiding framework to discuss the current state of knowledge of chromatin remodeling mechanisms and highlight exciting open questions that would continue to benefit from biophysical analyses.
authors.affiliation: Department of Biochemistry and Biophysics, University of California, San Francisco, California, 94158; email: coral.zhou@ucsf.edu , stephanie.johnson@ucsf.edu , nathan.gamarra@ucsf.edu , geeta.narlikar@ucsf.edu.
authors.forename: Coral Y
authors.initials: CY
authors.lastname: Zhou
authors.affiliation: Department of Biochemistry and Biophysics, University of California, San Francisco, California, 94158; email: coral.zhou@ucsf.edu , stephanie.johnson@ucsf.edu , nathan.gamarra@ucsf.edu , geeta.narlikar@ucsf.edu.
authors.forename: Stephanie L
authors.initials: SL
authors.lastname: Johnson
authors.affiliation: Department of Biochemistry and Biophysics, University of California, San Francisco, California, 94158; email: coral.zhou@ucsf.edu , stephanie.johnson@ucsf.edu , nathan.gamarra@ucsf.edu , geeta.narlikar@ucsf.edu.
authors.forename: Nathan I
authors.initials: NI
authors.lastname: Gamarra
authors.affiliation: Department of Biochemistry and Biophysics, University of California, San Francisco, California, 94158; email: coral.zhou@ucsf.edu , stephanie.johnson@ucsf.edu , nathan.gamarra@ucsf.edu , geeta.narlikar@ucsf.edu.
authors.forename: Geeta J
authors.initials: GJ
authors.lastname: Narlikar
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D002843:Chromatin / Q000502:physiology; D042002:Chromatin Assembly and Disassembly; D004247:DNA / Q000378:metabolism; D006801:Humans; D006868:Hydrolysis; D020409:Molecular Motor Proteins / Q000378:metabolism*; D009707:Nucleosomes / Q000502:physiology; D013379:Substrate Specificity
chemical_list: D002843:Chromatin; D020409:Molecular Motor Proteins; D009707:Nucleosomes; D000255:Adenosine Triphosphate; D004247:DNA; D000251:Adenosine Triphosphatases
keywords: ATPase; INO80; ISWI; SWI/SNF; SWR; histones; molecular motors; nucleosome