title: Is There a Tendency for Thrombosis in Gestational Diabetes Mellitus?
abstract: BACKGROUND
  Impact of gestational diabetes mellitus (GDM) on the coagulation system, dynamics involved at a pathophysiological level and the exact mechanism remain unclear.
  
  
  OBJECTIVE
  To evaluate the association between diabetes-related parameters and hemostatic factors to search for a tendency of thrombosis in GDM.
  
  
  METHODS
  Nineteen pregnant women who had GDM, 16 healthy pregnant and 13 healthy nonpregnant controls admitted to the Endocrinology outpatient clinics were enrolled in the study.
  
  
  METHODS
  Fasting and postprandial glucose, hemoglobin A1c and insulin levels, and insulin resistance; fructosamine, thrombin activatable fibrinolysis inhibitor (TAFI), tissue factor pathway inhibitor (TFPI), plasminogen activator inhibitor Type-1 (PAI-1), tissue-type plasminogen activator (t-PA), fibrinogen, plasminogen and hemoglobin levels, platelet counts, prothrombin time (PT), and activated partial thromboplastin time (aPTT) were studied.
  
  
  METHODS
  One-way analysis of variance, Kruskal-Wallis, and post hoc Tukey honestly significant difference or Conover's nonparametric multiple comparison tests for comparison of the study groups.
  
  
  RESULTS
  PT and aPTT were significantly lower in GDM patients compared to controls (P < 0.05), whereas fibrinogen and plasminogen levels were significantly higher in this group compared to both nonpregnant and healthy pregnant controls (P < 0.05 for each). TAFI, TFPI, PAI-1, and tissue t-PA levels were not significantly different among groups.
  
  
  CONCLUSIONS
  Our findings indicate tendency to develop thrombosis in GDM similar to diabetes mellitus; but more comprehensive studies with larger sample size are needed to determine the relationship between GDM and hemostasis.
authors.affiliation: Department of Endocrinology and Metabolism, Antalya Training and Research Hospital, Antalya, Turkey.
authors.forename: Suheyla
authors.initials: S
authors.lastname: Gorar
authors.affiliation: Department of Pediatric Hematology, Director of Hematology Laboratories, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Bulent
authors.initials: B
authors.lastname: Alioglu
authors.affiliation: Department of Endocrinology and Metabolism, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Esranur
authors.initials: E
authors.lastname: Ademoglu
authors.affiliation: Department of Internal Medicine, Antalya Training and Research Hospital, Antalya, Turkey.
authors.forename: Seyit
authors.initials: S
authors.lastname: Uyar
authors.affiliation: Department of Endocrinology and Metabolism, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Handan
authors.initials: H
authors.lastname: Bekdemir
authors.affiliation: Department of Endocrinology and Metabolism, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Zehra
authors.initials: Z
authors.lastname: Candan
authors.affiliation: Department of Pediatric Hematology, Hematology Laboratories, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Beylan
authors.initials: B
authors.lastname: Saglam
authors.affiliation: Department of Endocrinology and Metabolism, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Gonul
authors.initials: G
authors.lastname: Koc
authors.affiliation: Department of Endocrinology and Metabolism, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Cavit
authors.initials: C
authors.lastname: Culha
authors.affiliation: Department of Endocrinology and Metabolism, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Yalcin
authors.initials: Y
authors.lastname: Aral
keywords: Gestational diabetes mellitus; hemostatic factors; thrombosis