title: Early mobilization versus bed rest for deep vein thrombosis.
abstract: Aiming to prevent thromboembolic events, bed rest was historically considered in the management of patient with deep vein thrombosis. Nevertheless early ambulation could have beneficial effects. Searching in Epistemonikos database, which is maintained by screening 30 databases, we identified seven systematic reviews including 10 randomized trials answering this question. We combined the evidence using meta-analysis and generated a summary of findings table following the GRADE approach. We concluded early ambulation is probably effective in reducing deep vein thrombosis progression and improving limb pain, and might not increase the risk of thromboembolism.
authors.affiliation: Servicio de Clínica Médica, Hospital Alemán, Buenos Aires, Argentina; Programa de Medicina Basada en Pruebas, Hospital Alemán, Buenos Aires, Argentina. Address: Hospital Alemán de Buenos Aires, Av. Pueyrredon 1640, CP C118AAT, +54114827700. Email: federicopopoff@gmail.com.
authors.forename: Ariel
authors.initials: A
authors.lastname: Izcovich
authors.affiliation: Servicio de Clínica Médica, Hospital Alemán, Buenos Aires, Argentina; Programa de Medicina Basada en Pruebas, Hospital Alemán, Buenos Aires, Argentina.
authors.forename: Federico
authors.initials: F
authors.lastname: Popoff
authors.affiliation: Programa de Salud Basada en Evidencia, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Departamento de Medicina Interna, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; GRADE working group; The Cochrane Collaboration; Fundación Epistemonikos, Santiago, Chile.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Rada
mesh_terms: D001510:Bed Rest / Q000379:methods*; D018450:Disease Progression; D004434:Early Ambulation / Q000379:methods*; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D013923:Thromboembolism / Q000517:prevention & control; D020246:Venous Thrombosis / Q000473:pathology / Q000628:therapy*