title: A Multicenter Clinical Study on Treating Post-Dural Puncture Headache with an Intravenous Injection of Aminophylline.
abstract: Post-dural puncture headache (PDPH) is the most common complication of lumbar puncture. Aminophylline has been reported to be effective in the prevention of PDPH in some clinical studies, but its efficacy for the treatment of PDPH has been unproven.
  
  
  
  To evaluate the efficacy and safety of an intravenous (IV) injection of aminophylline on PDPH.
  
  
  
  The study was a multicenter, open-label study to assess the effectiveness and safety of aminophylline on PDPH.
  
  
  
  The First Affiliated Hospital of Zhengzhou University, The Fifth Affiliated Hospital of Zhengzhou University, and Henan Province Hospital of Traditional Chinese Medicine.
  
  
  
  Thirty-two PDPH patients received an IV injection of aminophylline. The primary and secondary endpoints were the degree of headache and the patient's overall response to the treatment, respectively. Treatment safety was evaluated based on the occurrence of adverse reactions.
  
  
  
  Thirty-one patients completed the study. Before the initial aminophylline administration, the visual analog scale (VAS) score was 7.72 ± 1.65. The VAS scores at 30 minutes, one hour, 8 hours, one day, and 2 days post-treatment were 4.84 ± 2.53, 3.53 ± 2.06, 2.38 ± 1.96, 1.44 ± 1.87, and 0.81 ± 1.79, respectively, and were statistically significantly different (P < 0.05) compared with those before treatment. More than 50% (17/32) of the patients reported that they were "very much improved" or "much improved" 30 minutes after the initial treatment, increasing to 93.8% (30/32) at 2 days post-treatment. One patient experienced mild allergic reaction after treatment.
  
  
  
  Although this study had the largest sample size among current studies on treating PDPH with theophylline drugs, the sample size was still relatively small and the method employed was not compared with a placebo or other current clinical treatments for PDPH.
  
  
  
  An IV injection of aminophylline may be an effective and safe early-stage treatment for PDPH.
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Chuanjie
authors.initials: C
authors.lastname: Wu
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Yajun
authors.initials: Y
authors.lastname: Lian
authors.affiliation: Department of Neurology, Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou, China.
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Guan
authors.affiliation: Department of Neurology, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Neurology, Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou, China.
authors.forename: Yanyong
authors.initials: Y
authors.lastname: Miao
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Nanchang
authors.initials: N
authors.lastname: Xie
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Yake
authors.initials: Y
authors.lastname: Zheng
mesh_terms: D000328:Adult; D000368:Aged; D000628:Aminophylline / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D051299:Post-Dural Puncture Headache / Q000188:drug therapy*; D058915:Purinergic P1 Receptor Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D058915:Purinergic P1 Receptor Antagonists; D000628:Aminophylline