title: Efficacy of adoptive cellular therapy in patients with gastric cancer: a meta-analysis.
abstract: To systemically evaluate the efficacy and safety of adoptive cellular therapy for the treatment of gastric cancer (GC).
  
  
  
  We performed a systemic review and meta-analysis of nine eligible trials with GC and evaluated the effect of adoptive cellular therapy on the overall survival (OS) rate, T-cell subsets and adverse events.
  
  
  
  Overall, 829 patients were involved in the analysis. Adoptive cellular therapy significantly improved the OS rate compared with the control group. Meanwhile, we observed greatly increased percentages of CD3(+), CD4(+) and CD4(+)/CD8(+) in cellular therapy groups.
  
  
  
  Adoptive cellular therapy combined with adjuvant therapy resulted in significantly better OS rates, progression-free survival and T-lymphocyte responses in patients with GC.
authors.affiliation: Institute for Health Education, Jiangsu Provincial Center for Disease Control & Prevention, 172 Jiangsu Road, Nanjing 210009, P.R. China.
authors.forename: Dong
authors.initials: D
authors.lastname: Shen
authors.affiliation: Institute for Health Education, Jiangsu Provincial Center for Disease Control & Prevention, 172 Jiangsu Road, Nanjing 210009, P.R. China.
authors.forename: Zhi-Hao
authors.initials: ZH
authors.lastname: Liu
authors.affiliation: Department of Oncology, the Affiliated Jiangyin Hospital of Southeast University Medical College, 163 Shoushan Road, Jiangyin 214400, P.R. China.
authors.forename: Jia-Ning
authors.initials: JN
authors.lastname: Xu
authors.affiliation: The Third Affiliated Hospital of Beijing University of Traditional Chinese Medicine, 51 XiaoGuan Street, AnDingMen, ChaoYang District, Beijing 100029, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Xu
authors.affiliation: Department of Oncology, the Affiliated Jiangyin Hospital of Southeast University Medical College, 163 Shoushan Road, Jiangyin 214400, P.R. China.
authors.forename: Qin-Feng
authors.initials: QF
authors.lastname: Lin
authors.affiliation: Department of Oncology, the Affiliated Jiangyin Hospital of Southeast University Medical College, 163 Shoushan Road, Jiangyin 214400, P.R. China.
authors.forename: Feng
authors.initials: F
authors.lastname: Lin
authors.affiliation: Department of Oncology, the Affiliated Jiangyin Hospital of Southeast University Medical College, 163 Shoushan Road, Jiangyin 214400, P.R. China.
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Mao
mesh_terms: D000818:Animals; D016516:CD4-CD8 Ratio; D064420:Drug-Related Side Effects and Adverse Reactions / Q000276:immunology*; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000379:methods*; D008213:Lymphocyte Activation; D013274:Stomach Neoplasms / Q000276:immunology / Q000401:mortality / Q000628:therapy*; D016019:Survival Analysis; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000637:transplantation
keywords: adoptive cellular therapy; gastric cancer; meta-analysis