title: Acute Alcoholic Hepatitis, the Clinical Aspects.
abstract: Alcoholic hepatitis is an acute form of alcoholic liver disease with variable severity that develops in patients who usually have a history of prolonged and recent alcohol abuse. The diagnosis is clinical and depends on history, physical examination, and laboratory derangements. Liver biopsy is diagnostic but not universally performed, and noninvasive diagnostic modalities are under development. Scoring systems are used to assess severity of disease, predict mortality, and guide decisions for initiation of specific therapies. The natural history and long-term outcomes of alcoholic hepatitis, including recurrence, progression to cirrhosis, and mortality, vary and depend partly on abstinence from alcohol use.
authors.affiliation: Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, 200 Lothrop Street, UPMC Presbyterian, M2, C-Wing, Pittsburgh, PA 15213, USA.
authors.forename: Mohannad F
authors.initials: MF
authors.lastname: Dugum
authors.affiliation: Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, 9500 Euclid Avenue, A30, Cleveland, OH 44195, USA. Electronic address: mcculla@ccf.org.
authors.forename: Arthur J
authors.initials: AJ
authors.lastname: McCullough
mesh_terms: D064829:Alcohol Abstinence; D001706:Biopsy; D018450:Disease Progression; D005260:Female; D006519:Hepatitis, Alcoholic / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D006801:Humans; D008297:Male; D008954:Models, Biological; D011379:Prognosis; D012008:Recurrence; D012307:Risk Factors; D012720:Severity of Illness Index
keywords: Alcoholic hepatitis; Alcoholic liver disease; Clinical outcomes; Diagnosis