title: Is Coenzyme Q10 Effective in Protection against Ulcerative Colitis? An Experimental Study in Rats.
abstract: Coenzyme Q10 (Co-Q10) is a vitamin-like supplement which appears to be safe, with minimal side effects and low drug interaction potential. Co-Q10 is used in the treatment of a variety of disorders related primarily to suboptimal cellular energy metabolism and oxidative injury. Studies supporting the efficacy of Co-Q10 appear most promising for a variety of diseases, including ulcerative colitis (UC). The present investigation aims to elucidate the possible protective effects of Co-Q10 against UC, as induced by the administration of iodoacetamide to adult male albino rats. In our study, Co-Q10 showed potent anti-oxidant and anti-inflammatory activities through a significant increase in catalase activity and glutathione content. In addition, it significantly decreased myeloperoxidase activity, malondialdehyde content and nitrate/nitrite production. These results suggest that Co-Q10 protects against UC in rats via anti-oxidant and anti-inflammatory potentials, and therefore seems promising for use in further clinical trials.
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Nahda University.
authors.forename: Mohamed Gamal
authors.initials: MG
authors.lastname: Ewees
authors.forename: Basim Anwar Shehata
authors.initials: BA
authors.lastname: Messiha
authors.forename: Ali Ahmed
authors.initials: AA
authors.lastname: Abo-Saif
authors.forename: Hekma Abd El-Tawab
authors.initials: HA
authors.lastname: Abd El-Latif
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D002374:Catalase / Q000378:metabolism; D003093:Colitis, Ulcerative / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D003106:Colon / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D005978:Glutathione / Q000378:metabolism; D007460:Iodoacetamide; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009589:Nitrogen Oxides / Q000378:metabolism; D009195:Peroxidase / Q000378:metabolism; D017208:Rats, Wistar; D014451:Ubiquinone / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D009589:Nitrogen Oxides; D014451:Ubiquinone; D008315:Malondialdehyde; D002374:Catalase; D009195:Peroxidase; D005978:Glutathione; C025203:Ubiquinone Q1; D007460:Iodoacetamide