title: [Long-term outcome of budesonide middle meatus treatment for chronic rhinosinusitis patients following endoscopic sinus surgery].
abstract: OBJECTIVE
  To investigate the long term clinical effect of budesonide treatment in middle meatus for chronic rhinosinusitis(CRS) following endoscopic sinus surgery (ESS).
  
  
  METHODS
  A total number of 53 patients with CRS received ESS were divided into two groups according to budesonide treatment: budesonide-treated group with 21 cases (39.6%) and control group with 32 cases (60.4%). Gelatin sponges soaked with 1 ml budesonide suspension were put in middle meatus in budesonide-treated group, while only gelatin sponges were put in middle meatus in control group. Visual analogy score (VAS), sino-nasal outcome test-22 (SNOT-22) and Lund-Kennedy endoscopic scale were carried out before ESS and two years after ESS.
  
  
  RESULTS
  In budesonide-treated group, there were a statistical difference before and after ESS in the VAS, SNOT-20 and Lund-Kennedy score (P<. 05). In control group, difference was also significant in VAS, SNOT-20 and Lund-Kennedy score before and after ESS (P < 0.05). The VAS gap of post-operative and pre-operative in two groups are significantly different (P<. 05). However, there was no significant difference in the SNOT-20 and Lund-Kennedy endoscopic scale gap before or after the operation between two groups.
  
  
  CONCLUSIONS
  It is safe, convenient and practicable to perform budesonide treatment in middle meatus following ESS, which can significantly ease the post-operative discomfort of nose.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Chen
authors.forename: Haiting
authors.initials: H
authors.lastname: Wang
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Shi
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Li
authors.forename: Boyi
authors.initials: B
authors.lastname: Shan
authors.forename: Tao
authors.initials: T
authors.lastname: Xue
authors.forename: Li
authors.initials: L
authors.lastname: Qiao
authors.forename: Fuquan
authors.initials: F
authors.lastname: Chen
mesh_terms: D019819:Budesonide / Q000627:therapeutic use*; D002908:Chronic Disease; D004724:Endoscopy; D006801:Humans; D009666:Nose; D010256:Paranasal Sinuses / Q000601:surgery*; D011184:Postoperative Period; D012220:Rhinitis / Q000188:drug therapy*; D012852:Sinusitis / Q000188:drug therapy*
chemical_list: D019819:Budesonide