title: Antitumor activity of polysaccharide from Laminaria japonica on mice bearing H22 liver cancer.
abstract: Water-soluble polysaccharide was extracted from Laminaria japonica, and its antitumor effect on mice bearing H22 liver cancer was investigated. The mice were inoculated with H22 hepatoma cells and randomly divided into four groups: three treatment groups that received 50, 100 and 150mg/kg L. japonica polysaccharide (LJP) intraperitoneal injection and one control group that received equal volume of physiological saline. Intraperitoneal injection of LJP increased serum interleukin-2 and tumour necrosis factor-α levels, as well as tumour inhibition rate of mice, but decreased serum vascular endothelial growth factor level. Therefore, LJP exerts antitumor effect and can be used as a therapeutic agent for cancer.
authors.affiliation: Maternal and Child Health Hospital, 399 Century Boulevard, Nantong, 226010, China.
authors.forename: Qingwen
authors.initials: Q
authors.lastname: Zhu
authors.affiliation: Maternal and Child Health Hospital, 399 Century Boulevard, Nantong, 226010, China.
authors.forename: Jianghua
authors.initials: J
authors.lastname: Chen
authors.affiliation: Center for Reproduction and Genetics, Nanjing Medical University Affiliated Suzhou Hospital, 26 Daoqian Street, Suzhou, 215002, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Li
authors.affiliation: Center for Reproduction and Genetics, Nanjing Medical University Affiliated Suzhou Hospital, 26 Daoqian Street, Suzhou, 215002, China. Electronic address: wangtingszh@sina.com.
authors.forename: Ting
authors.initials: T
authors.lastname: Wang
authors.affiliation: Center for Reproduction and Genetics, Nanjing Medical University Affiliated Suzhou Hospital, 26 Daoqian Street, Suzhou, 215002, China. Electronic address: lihaiboszh@163.com.
authors.forename: Haibo
authors.initials: H
authors.lastname: Li
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D007795:Laminaria / Q000737:chemistry*; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D051379:Mice; D011134:Polysaccharides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D011134:Polysaccharides
keywords: Antitumor; Laminaria japonica; Polysaccharide