title: Complement-coagulation crosstalk on cellular and artificial surfaces.
abstract: The humoral serine proteases of the complement system and the coagulation system play central roles during the events of an inflammatory response. While the complement system confers immunoprotective and -regulatory functions, the coagulation cascade is responsible to ensure hemostatic maintenance. Although these two systems individually unfold during inflammation, several studies have reported on the "crosstalk" between components of the complement and the coagulation system in the fluid phase. However, both cascades are usually initiated on or in close proximity to foreign or activated surfaces, and there is increasing evidence for interacting complement and coagulation proteins on various superficial areas on endothelium, circulating entities like platelets, leukocytes, microparticles and pathogens, and even on artificial surfaces. This review aims at summarizing these interactions to complete the picture.
authors.affiliation: Department of Orthopedic Trauma, Hand-, Plastic- and Reconstructive Surgery, University Hospital of Ulm, Germany.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Wiegner
authors.affiliation: Department of Orthopedic Trauma, Hand-, Plastic- and Reconstructive Surgery, University Hospital of Ulm, Germany.
authors.forename: Shinjini
authors.initials: S
authors.lastname: Chakraborty
authors.affiliation: Department of Orthopedic Trauma, Hand-, Plastic- and Reconstructive Surgery, University Hospital of Ulm, Germany. Electronic address: markus.huber-lang@uniklinik-ulm.de.
authors.forename: Markus
authors.initials: M
authors.lastname: Huber-Lang
mesh_terms: D000818:Animals; D001773:Blood Cells / Q000276:immunology / Q000378:metabolism; D001777:Blood Coagulation; D001779:Blood Coagulation Factors / Q000378:metabolism; D003165:Complement System Proteins / Q000502:physiology*; D006801:Humans; D011485:Protein Binding; D015398:Signal Transduction
chemical_list: D001779:Blood Coagulation Factors; D003165:Complement System Proteins
keywords: Artificial surfaces; Cellular surfaces; Coagulation; Complement; Crosstalk