title: Comparison of the serum toxicokinetics of larkspur toxins in cattle, sheep and goats.
abstract: Larkspurs (Delphinium spp.) are a major cause of cattle losses in western North America, whereas sheep are thought to be resistant to larkspur toxicosis. Goats are often used as a small ruminant model to study poisonous plants. In this study, we compared the serum toxicokinetic profile of toxic larkspur alkaloids from Delphinium barbeyi in cattle, goats, and sheep. The results from this study indicate that kinetic differences could partially explain species differences in susceptibility to larkspur toxicosis.
authors.affiliation: USDA-ARS Poisonous Plant Research Laboratory, Logan, UT 84341, United States. Electronic address: Kevin.Welch@ars.usda.gov.
authors.forename: K D
authors.initials: KD
authors.lastname: Welch
authors.affiliation: USDA-ARS Poisonous Plant Research Laboratory, Logan, UT 84341, United States.
authors.forename: D R
authors.initials: DR
authors.lastname: Gardner
authors.affiliation: USDA-ARS Poisonous Plant Research Laboratory, Logan, UT 84341, United States.
authors.forename: B T
authors.initials: BT
authors.lastname: Green
authors.affiliation: USDA-ARS Poisonous Plant Research Laboratory, Logan, UT 84341, United States.
authors.forename: C A
authors.initials: CA
authors.lastname: Stonecipher
authors.affiliation: USDA-ARS Poisonous Plant Research Laboratory, Logan, UT 84341, United States.
authors.forename: D
authors.initials: D
authors.lastname: Cook
authors.affiliation: USDA-ARS Poisonous Plant Research Laboratory, Logan, UT 84341, United States.
authors.forename: J A
authors.initials: JA
authors.lastname: Pfister
mesh_terms: D000818:Animals; D002417:Cattle; D031882:Delphinium / Q000737:chemistry*; D006041:Goats; D012756:Sheep; D066007:Toxicokinetics; D014118:Toxins, Biological / Q000097:blood* / Q000493:pharmacokinetics / Q000633:toxicity
chemical_list: D014118:Toxins, Biological
keywords: Cattle; Delphinium; Deltaline; Goats; Larkspur; Methyllycaconitine; Sheep; Toxicokinetics