title: Silicon Nanoparticles as Amplifiers of the Ultrasonic Effect in Sonodynamic Therapy.
abstract: The possibility of using mesoporous silicon nanoparticles as amplifiers (sensitizers) of therapeutic ultrasonic exposure were studied experimentally in vitro and in vivo. The combination of nanoparticles and ultrasound led to a significant inhibition of Hep-2 cancer cell proliferation and Lewis lung carcinoma growth in mice. These results indicated good prospects of using silicon nanoparticles as sensitizers for sonodynamic therapy of tumors.
authors.affiliation: Physical Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia. osminkina@mig.phys.msu.ru.
authors.forename: L A
authors.initials: LA
authors.lastname: Osminkina
authors.affiliation: Institute of Theoretical and Experimental Biophysics, the Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Kudryavtsev
authors.affiliation: N. N. Blokhin Russian Cancer Research Center, Moscow, Russia.
authors.forename: S V
authors.initials: SV
authors.lastname: Zinovyev
authors.affiliation: Physical Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia.
authors.forename: A P
authors.initials: AP
authors.lastname: Sviridov
authors.affiliation: Physical Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia.
authors.forename: Yu V
authors.initials: YV
authors.lastname: Kargina
authors.affiliation: Physical Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia.
authors.forename: K P
authors.initials: KP
authors.lastname: Tamarov
authors.affiliation: Physical Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia.
authors.forename: V N
authors.initials: VN
authors.lastname: Nikiforov
authors.affiliation: N. N. Blokhin Russian Cancer Research Center, Moscow, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Ivanov
authors.affiliation: Physical Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia.|Ural Federal University, Ekaterinburg, Russia.
authors.forename: A N
authors.initials: AN
authors.lastname: Vasilyev
authors.affiliation: Physical Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia.
authors.forename: V Yu
authors.initials: VY
authors.lastname: Timoshenko
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008297:Male; D008808:Mice, Inbred CBA; D053758:Nanoparticles / Q000737:chemistry; D009368:Neoplasm Transplantation; D012825:Silicon / Q000008:administration & dosage* / Q000737:chemistry; D000069453:Ultrasonic Waves
chemical_list: D000970:Antineoplastic Agents; D012825:Silicon
keywords: nanoparticles; sonodynamic therapy; tumor; ultrasound