title: Decarboxylative Anti-Michael Addition to Olefins Mediated by Photoredox Catalysis.
abstract: Decarboxylative coupling of carboxylic acids with activated olefins has been accomplished using visible light photoredox catalysis. The strategic placement of a radical-stabilizing aromatic group at the β-position of the olefin component biases the regioselectivity of the addition, allowing reliable, facile access to anti-Michael-type products from readily available precursors. The scope of this methodology was demonstrated with a range of carboxylic acids and appropriately substituted olefins and was applied toward a two-step synthesis of the antiarrhythmic agent encainide.
authors.affiliation: Department of Medicinal Chemistry, Amgen Inc. , 360 Binney Street, Cambridge, Massachusetts 02142, United States.
authors.forename: Gabrielle H
authors.initials: GH
authors.lastname: Lovett
authors.affiliation: Department of Medicinal Chemistry, Amgen Inc. , 360 Binney Street, Cambridge, Massachusetts 02142, United States.
authors.forename: Brian A
authors.initials: BA
authors.lastname: Sparling