title: Relation Between Insulin Sensitivity and Metabolic Abnormalities in Japanese Men With BMI of 23-25 kg/m2.
abstract: Although metabolic abnormalities are often developed in Asians with body mass index (BMI) of 23-25 kg/m2, the characteristics of the nonobese Asians with metabolic abnormality have not been fully understood.
  
  
  
  The aim of this study was to investigate the clinical significance of insulin sensitivity in Japanese men with BMI of 23-25 kg/m2.
  
  
  
  In this study, we defined hypertension, hyperglycemia, and dyslipidemia as cardiometabolic risk factors (CMRFs). We recruited subjects who met the following selection criteria: men with BMI of 21-23 kg/m2and no CMRF (n = 24); men with BMI of 23-25 kg/m2and no CMRF (n = 28), or one CMRF (n = 28), or at least two CMRFs (n = 14); and overweight men with metabolic syndrome (n = 20). Insulin sensitivity (IS) and ectopic fat content in muscle and liver were measured by two-step hyperinsulinemic-euglycemic clamp and1H-magnetic resonance spectroscopy, respectively.
  
  
  
  Among subjects with BMI of 23-25 kg/m2, impaired IS in muscle, but not in liver, was found in those with even one CMRF, whereas impaired IS in both muscle and liver was observed in overweight men with metabolic syndrome. Liver fat accumulation and elevated liver enzymes were associated with impaired IS in both muscle and liver in those subjects.
  
  
  
  Among Japanese men with BMI of 23-25 kg/m2, muscle insulin resistance was present in those with even one CMRF. In this population, liver fat accumulation and/or elevated liver enzymes could be a good marker for impaired IS in both muscle and liver.
authors.affiliation: Department of Metabolism & Endocrinology (K.T., Y.T., M.Ka., S.K., T.W., T.Fun. Y.Fur., H.K., R.Y., A.K., Y.Fuj., R.K., H.W.), Sportology Center (Y.T., S.K., R.Y., M.Ki., K.S., H.D., S.A., R.K., H.W.), Department of Cardiology (M.N.-Y., K.S., H.D.), Department of Radiology (S.A.), Laboratory of Proteomics and Biomolecular Science, Research Support Center (H.T., T.Fuj.), Center for Therapeutic Innovations in Diabetes (H.W.), and Center for Molecular Diabetology (H.W.), Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan; Department of Health Promotion and Exercise (S.S.S.), National Institute of Health and Nutrition, Tokyo 162-8636, Japan; and Departments of Physiology and Medicine (A.G.), Institute of Medical Science and Banting and Best Diabetes Centre, University of Toronto, Toronto, ON M5G 2C4, Canada.
authors.forename: Kageumi
authors.initials: K
authors.lastname: Takeno
authors.affiliation: Department of Metabolism & Endocrinology (K.T., Y.T., M.Ka., S.K., T.W., T.Fun. Y.Fur., H.K., R.Y., A.K., Y.Fuj., R.K., H.W.), Sportology Center (Y.T., S.K., R.Y., M.Ki., K.S., H.D., S.A., R.K., H.W.), Department of Cardiology (M.N.-Y., K.S., H.D.), Department of Radiology (S.A.), Laboratory of Proteomics and Biomolecular Science, Research Support Center (H.T., T.Fuj.), Center for Therapeutic Innovations in Diabetes (H.W.), and Center for Molecular Diabetology (H.W.), Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan; Department of Health Promotion and Exercise (S.S.S.), National Institute of Health and Nutrition, Tokyo 162-8636, Japan; and Departments of Physiology and Medicine (A.G.), Institute of Medical Science and Banting and Best Diabetes Centre, University of Toronto, Toronto, ON M5G 2C4, Canada.
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Tamura
authors.affiliation: Department of Metabolism & Endocrinology (K.T., Y.T., M.Ka., S.K., T.W., T.Fun. Y.Fur., H.K., R.Y., A.K., Y.Fuj., R.K., H.W.), Sportology Center (Y.T., S.K., R.Y., M.Ki., K.S., H.D., S.A., R.K., H.W.), Department of Cardiology (M.N.-Y., K.S., H.D.), Department of Radiology (S.A.), Laboratory of Proteomics and Biomolecular Science, Research Support Center (H.T., T.Fuj.), Center for Therapeutic Innovations in Diabetes (H.W.), and Center for Molecular Diabetology (H.W.), Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan; Department of Health Promotion and Exercise (S.S.S.), National Institute of Health and Nutrition, Tokyo 162-8636, Japan; and Departments of Physiology and Medicine (A.G.), Institute of Medical Science and Banting and Best Diabetes Centre, University of Toronto, Toronto, ON M5G 2C4, Canada.
authors.forename: Minako
authors.initials: M
authors.lastname: Kawaguchi
authors.affiliation: Department of Metabolism & Endocrinology (K.T., Y.T., M.Ka., S.K., T.W., T.Fun. Y.Fur., H.K., R.Y., A.K., Y.Fuj., R.K., H.W.), Sportology Center (Y.T., S.K., R.Y., M.Ki., K.S., H.D., S.A., R.K., H.W.), Department of Cardiology (M.N.-Y., K.S., H.D.), Department of Radiology (S.A.), Laboratory of Proteomics and Biomolecular Science, Research Support Center (H.T., T.Fuj.), Center for Therapeutic Innovations in Diabetes (H.W.), and Center for Molecular Diabetology (H.W.), Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan; Department of Health Promotion and Exercise (S.S.S.), National Institute of Health and Nutrition, Tokyo 162-8636, Japan; and Departments of Physiology and Medicine (A.G.), Institute of Medical Science and Banting and Best Diabetes Centre, University of Toronto, Toronto, ON M5G 2C4, Canada.
authors.forename: Saori
authors.initials: S
authors.lastname: Kakehi
authors.affiliation: Department of Metabolism & Endocrinology (K.T., Y.T., M.Ka., S.K., T.W., T.Fun. Y.Fur., H.K., R.Y., A.K., Y.Fuj., R.K., H.W.), Sportology Center (Y.T., S.K., R.Y., M.Ki., K.S., H.D., S.A., R.K., H.W.), Department of Cardiology (M.N.-Y., K.S., H.D.), Department of Radiology (S.A.), Laboratory of Proteomics and Biomolecular Science, Research Support Center (H.T., T.Fuj.), Center for Therapeutic Innovations in Diabetes (H.W.), and Center for Molecular Diabetology (H.W.), Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan; Department of Health Promotion and Exercise (S.S.S.), National Institute of Health and Nutrition, Tokyo 162-8636, Japan; and Departments of Physiology and Medicine (A.G.), Institute of Medical Science and Banting and Best Diabetes Centre, University of Toronto, Toronto, ON M5G 2C4, Canada.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Watanabe
authors.affiliation: Department of Metabolism & Endocrinology (K.T., Y.T., M.Ka., S.K., T.W., T.Fun. Y.Fur., H.K., R.Y., A.K., Y.Fuj., R.K., H.W.), Sportology Center (Y.T., S.K., R.Y., M.Ki., K.S., H.D., S.A., R.K., H.W.), Department of Cardiology (M.N.-Y., K.S., H.D.), Department of Radiology (S.A.), Laboratory of Proteomics and Biomolecular Science, Research Support Center (H.T., T.Fuj.), Center for Therapeutic Innovations in Diabetes (H.W.), and Center for Molecular Diabetology (H.W.), Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan; Department of Health Promotion and Exercise (S.S.S.), National Institute of Health and Nutrition, Tokyo 162-8636, Japan; and Departments of Physiology and Medicine (A.G.), Institute of Medical Science and Banting and Best Diabetes Centre, University of Toronto, Toronto, ON M5G 2C4, Canada.
authors.forename: Takashi
authors.initials: T
authors.lastname: Funayama
authors.affiliation: Department of Metabolism & Endocrinology (K.T., Y.T., M.Ka., S.K., T.W., T.Fun. Y.Fur., H.K., R.Y., A.K., Y.Fuj., R.K., H.W.), Sportology Center (Y.T., S.K., R.Y., M.Ki., K.S., H.D., S.A., R.K., H.W.), Department of Cardiology (M.N.-Y., K.S., H.D.), Department of Radiology (S.A.), Laboratory of Proteomics and Biomolecular Science, Research Support Center (H.T., T.Fuj.), Center for Therapeutic Innovations in Diabetes (H.W.), and Center for Molecular Diabetology (H.W.), Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan; Department of Health Promotion and Exercise (S.S.S.), National Institute of Health and Nutrition, Tokyo 162-8636, Japan; and Departments of Physiology and Medicine (A.G.), Institute of Medical Science and Banting and Best Diabetes Centre, University of Toronto, Toronto, ON M5G 2C4, Canada.
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Furukawa
authors.affiliation: Department of Metabolism & Endocrinology (K.T., Y.T., M.Ka., S.K., T.W., T.Fun. Y.Fur., H.K., R.Y., A.K., Y.Fuj., R.K., H.W.), Sportology Center (Y.T., S.K., R.Y., M.Ki., K.S., H.D., S.A., R.K., H.W.), Department of Cardiology (M.N.-Y., K.S., H.D.), Department of Radiology (S.A.), Laboratory of Proteomics and Biomolecular Science, Research Support Center (H.T., T.Fuj.), Center for Therapeutic Innovations in Diabetes (H.W.), and Center for Molecular Diabetology (H.W.), Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan; Department of Health Promotion and Exercise (S.S.S.), National Institute of Health and Nutrition, Tokyo 162-8636, Japan; and Departments of Physiology and Medicine (A.G.), Institute of Medical Science and Banting and Best Diabetes Centre, University of Toronto, Toronto, ON M5G 2C4, Canada.
authors.forename: Hideyoshi
authors.initials: H
authors.lastname: Kaga
authors.affiliation: Department of Metabolism & Endocrinology (K.T., Y.T., M.Ka., S.K., T.W., T.Fun. Y.Fur., H.K., R.Y., A.K., Y.Fuj., R.K., H.W.), Sportology Center (Y.T., S.K., R.Y., M.Ki., K.S., H.D., S.A., R.K., H.W.), Department of Cardiology (M.N.-Y., K.S., H.D.), Department of Radiology (S.A.), Laboratory of Proteomics and Biomolecular Science, Research Support Center (H.T., T.Fuj.), Center for Therapeutic Innovations in Diabetes (H.W.), and Center for Molecular Diabetology (H.W.), Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan; Department of Health Promotion and Exercise (S.S.S.), National Institute of Health and Nutrition, Tokyo 162-8636, Japan; and Departments of Physiology and Medicine (A.G.), Institute of Medical Science and Banting and Best Diabetes Centre, University of Toronto, Toronto, ON M5G 2C4, Canada.
authors.forename: Risako
authors.initials: R
authors.lastname: Yamamoto
authors.affiliation: Department of Metabolism & Endocrinology (K.T., Y.T., M.Ka., S.K., T.W., T.Fun. Y.Fur., H.K., R.Y., A.K., Y.Fuj., R.K., H.W.), Sportology Center (Y.T., S.K., R.Y., M.Ki., K.S., H.D., S.A., R.K., H.W.), Department of Cardiology (M.N.-Y., K.S., H.D.), Department of Radiology (S.A.), Laboratory of Proteomics and Biomolecular Science, Research Support Center (H.T., T.Fuj.), Center for Therapeutic Innovations in Diabetes (H.W.), and Center for Molecular Diabetology (H.W.), Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan; Department of Health Promotion and Exercise (S.S.S.), National Institute of Health and Nutrition, Tokyo 162-8636, Japan; and Departments of Physiology and Medicine (A.G.), Institute of Medical Science and Banting and Best Diabetes Centre, University of Toronto, Toronto, ON M5G 2C4, Canada.
authors.forename: Maengkyu
authors.initials: M
authors.lastname: Kim
authors.affiliation: Department of Metabolism & Endocrinology (K.T., Y.T., M.Ka., S.K., T.W., T.Fun. Y.Fur., H.K., R.Y., A.K., Y.Fuj., R.K., H.W.), Sportology Center (Y.T., S.K., R.Y., M.Ki., K.S., H.D., S.A., R.K., H.W.), Department of Cardiology (M.N.-Y., K.S., H.D.), Department of Radiology (S.A.), Laboratory of Proteomics and Biomolecular Science, Research Support Center (H.T., T.Fuj.), Center for Therapeutic Innovations in Diabetes (H.W.), and Center for Molecular Diabetology (H.W.), Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan; Department of Health Promotion and Exercise (S.S.S.), National Institute of Health and Nutrition, Tokyo 162-8636, Japan; and Departments of Physiology and Medicine (A.G.), Institute of Medical Science and Banting and Best Diabetes Centre, University of Toronto, Toronto, ON M5G 2C4, Canada.
authors.forename: Miho
authors.initials: M
authors.lastname: Nishitani-Yokoyama
authors.affiliation: Department of Metabolism & Endocrinology (K.T., Y.T., M.Ka., S.K., T.W., T.Fun. Y.Fur., H.K., R.Y., A.K., Y.Fuj., R.K., H.W.), Sportology Center (Y.T., S.K., R.Y., M.Ki., K.S., H.D., S.A., R.K., H.W.), Department of Cardiology (M.N.-Y., K.S., H.D.), Department of Radiology (S.A.), Laboratory of Proteomics and Biomolecular Science, Research Support Center (H.T., T.Fuj.), Center for Therapeutic Innovations in Diabetes (H.W.), and Center for Molecular Diabetology (H.W.), Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan; Department of Health Promotion and Exercise (S.S.S.), National Institute of Health and Nutrition, Tokyo 162-8636, Japan; and Departments of Physiology and Medicine (A.G.), Institute of Medical Science and Banting and Best Diabetes Centre, University of Toronto, Toronto, ON M5G 2C4, Canada.
authors.forename: Kazunori
authors.initials: K
authors.lastname: Shimada
authors.affiliation: Department of Metabolism & Endocrinology (K.T., Y.T., M.Ka., S.K., T.W., T.Fun. Y.Fur., H.K., R.Y., A.K., Y.Fuj., R.K., H.W.), Sportology Center (Y.T., S.K., R.Y., M.Ki., K.S., H.D., S.A., R.K., H.W.), Department of Cardiology (M.N.-Y., K.S., H.D.), Department of Radiology (S.A.), Laboratory of Proteomics and Biomolecular Science, Research Support Center (H.T., T.Fuj.), Center for Therapeutic Innovations in Diabetes (H.W.), and Center for Molecular Diabetology (H.W.), Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan; Department of Health Promotion and Exercise (S.S.S.), National Institute of Health and Nutrition, Tokyo 162-8636, Japan; and Departments of Physiology and Medicine (A.G.), Institute of Medical Science and Banting and Best Diabetes Centre, University of Toronto, Toronto, ON M5G 2C4, Canada.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Daida
authors.affiliation: Department of Metabolism & Endocrinology (K.T., Y.T., M.Ka., S.K., T.W., T.Fun. Y.Fur., H.K., R.Y., A.K., Y.Fuj., R.K., H.W.), Sportology Center (Y.T., S.K., R.Y., M.Ki., K.S., H.D., S.A., R.K., H.W.), Department of Cardiology (M.N.-Y., K.S., H.D.), Department of Radiology (S.A.), Laboratory of Proteomics and Biomolecular Science, Research Support Center (H.T., T.Fuj.), Center for Therapeutic Innovations in Diabetes (H.W.), and Center for Molecular Diabetology (H.W.), Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan; Department of Health Promotion and Exercise (S.S.S.), National Institute of Health and Nutrition, Tokyo 162-8636, Japan; and Departments of Physiology and Medicine (A.G.), Institute of Medical Science and Banting and Best Diabetes Centre, University of Toronto, Toronto, ON M5G 2C4, Canada.
authors.forename: Shigeki
authors.initials: S
authors.lastname: Aoki
authors.affiliation: Department of Metabolism & Endocrinology (K.T., Y.T., M.Ka., S.K., T.W., T.Fun. Y.Fur., H.K., R.Y., A.K., Y.Fuj., R.K., H.W.), Sportology Center (Y.T., S.K., R.Y., M.Ki., K.S., H.D., S.A., R.K., H.W.), Department of Cardiology (M.N.-Y., K.S., H.D.), Department of Radiology (S.A.), Laboratory of Proteomics and Biomolecular Science, Research Support Center (H.T., T.Fuj.), Center for Therapeutic Innovations in Diabetes (H.W.), and Center for Molecular Diabetology (H.W.), Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan; Department of Health Promotion and Exercise (S.S.S.), National Institute of Health and Nutrition, Tokyo 162-8636, Japan; and Departments of Physiology and Medicine (A.G.), Institute of Medical Science and Banting and Best Diabetes Centre, University of Toronto, Toronto, ON M5G 2C4, Canada.
authors.forename: Hikari
authors.initials: H
authors.lastname: Taka
authors.affiliation: Department of Metabolism & Endocrinology (K.T., Y.T., M.Ka., S.K., T.W., T.Fun. Y.Fur., H.K., R.Y., A.K., Y.Fuj., R.K., H.W.), Sportology Center (Y.T., S.K., R.Y., M.Ki., K.S., H.D., S.A., R.K., H.W.), Department of Cardiology (M.N.-Y., K.S., H.D.), Department of Radiology (S.A.), Laboratory of Proteomics and Biomolecular Science, Research Support Center (H.T., T.Fuj.), Center for Therapeutic Innovations in Diabetes (H.W.), and Center for Molecular Diabetology (H.W.), Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan; Department of Health Promotion and Exercise (S.S.S.), National Institute of Health and Nutrition, Tokyo 162-8636, Japan; and Departments of Physiology and Medicine (A.G.), Institute of Medical Science and Banting and Best Diabetes Centre, University of Toronto, Toronto, ON M5G 2C4, Canada.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Fujimura
authors.affiliation: Department of Metabolism & Endocrinology (K.T., Y.T., M.Ka., S.K., T.W., T.Fun. Y.Fur., H.K., R.Y., A.K., Y.Fuj., R.K., H.W.), Sportology Center (Y.T., S.K., R.Y., M.Ki., K.S., H.D., S.A., R.K., H.W.), Department of Cardiology (M.N.-Y., K.S., H.D.), Department of Radiology (S.A.), Laboratory of Proteomics and Biomolecular Science, Research Support Center (H.T., T.Fuj.), Center for Therapeutic Innovations in Diabetes (H.W.), and Center for Molecular Diabetology (H.W.), Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan; Department of Health Promotion and Exercise (S.S.S.), National Institute of Health and Nutrition, Tokyo 162-8636, Japan; and Departments of Physiology and Medicine (A.G.), Institute of Medical Science and Banting and Best Diabetes Centre, University of Toronto, Toronto, ON M5G 2C4, Canada.
authors.forename: Susumu S
authors.initials: SS
authors.lastname: Sawada
authors.affiliation: Department of Metabolism & Endocrinology (K.T., Y.T., M.Ka., S.K., T.W., T.Fun. Y.Fur., H.K., R.Y., A.K., Y.Fuj., R.K., H.W.), Sportology Center (Y.T., S.K., R.Y., M.Ki., K.S., H.D., S.A., R.K., H.W.), Department of Cardiology (M.N.-Y., K.S., H.D.), Department of Radiology (S.A.), Laboratory of Proteomics and Biomolecular Science, Research Support Center (H.T., T.Fuj.), Center for Therapeutic Innovations in Diabetes (H.W.), and Center for Molecular Diabetology (H.W.), Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan; Department of Health Promotion and Exercise (S.S.S.), National Institute of Health and Nutrition, Tokyo 162-8636, Japan; and Departments of Physiology and Medicine (A.G.), Institute of Medical Science and Banting and Best Diabetes Centre, University of Toronto, Toronto, ON M5G 2C4, Canada.
authors.forename: Adria
authors.initials: A
authors.lastname: Giacca
authors.affiliation: Department of Metabolism & Endocrinology (K.T., Y.T., M.Ka., S.K., T.W., T.Fun. Y.Fur., H.K., R.Y., A.K., Y.Fuj., R.K., H.W.), Sportology Center (Y.T., S.K., R.Y., M.Ki., K.S., H.D., S.A., R.K., H.W.), Department of Cardiology (M.N.-Y., K.S., H.D.), Department of Radiology (S.A.), Laboratory of Proteomics and Biomolecular Science, Research Support Center (H.T., T.Fuj.), Center for Therapeutic Innovations in Diabetes (H.W.), and Center for Molecular Diabetology (H.W.), Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan; Department of Health Promotion and Exercise (S.S.S.), National Institute of Health and Nutrition, Tokyo 162-8636, Japan; and Departments of Physiology and Medicine (A.G.), Institute of Medical Science and Banting and Best Diabetes Centre, University of Toronto, Toronto, ON M5G 2C4, Canada.
authors.forename: Akio
authors.initials: A
authors.lastname: Kanazawa
authors.affiliation: Department of Metabolism & Endocrinology (K.T., Y.T., M.Ka., S.K., T.W., T.Fun. Y.Fur., H.K., R.Y., A.K., Y.Fuj., R.K., H.W.), Sportology Center (Y.T., S.K., R.Y., M.Ki., K.S., H.D., S.A., R.K., H.W.), Department of Cardiology (M.N.-Y., K.S., H.D.), Department of Radiology (S.A.), Laboratory of Proteomics and Biomolecular Science, Research Support Center (H.T., T.Fuj.), Center for Therapeutic Innovations in Diabetes (H.W.), and Center for Molecular Diabetology (H.W.), Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan; Department of Health Promotion and Exercise (S.S.S.), National Institute of Health and Nutrition, Tokyo 162-8636, Japan; and Departments of Physiology and Medicine (A.G.), Institute of Medical Science and Banting and Best Diabetes Centre, University of Toronto, Toronto, ON M5G 2C4, Canada.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Fujitani
authors.affiliation: Department of Metabolism & Endocrinology (K.T., Y.T., M.Ka., S.K., T.W., T.Fun. Y.Fur., H.K., R.Y., A.K., Y.Fuj., R.K., H.W.), Sportology Center (Y.T., S.K., R.Y., M.Ki., K.S., H.D., S.A., R.K., H.W.), Department of Cardiology (M.N.-Y., K.S., H.D.), Department of Radiology (S.A.), Laboratory of Proteomics and Biomolecular Science, Research Support Center (H.T., T.Fuj.), Center for Therapeutic Innovations in Diabetes (H.W.), and Center for Molecular Diabetology (H.W.), Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan; Department of Health Promotion and Exercise (S.S.S.), National Institute of Health and Nutrition, Tokyo 162-8636, Japan; and Departments of Physiology and Medicine (A.G.), Institute of Medical Science and Banting and Best Diabetes Centre, University of Toronto, Toronto, ON M5G 2C4, Canada.
authors.forename: Ryuzo
authors.initials: R
authors.lastname: Kawamori
authors.affiliation: Department of Metabolism & Endocrinology (K.T., Y.T., M.Ka., S.K., T.W., T.Fun. Y.Fur., H.K., R.Y., A.K., Y.Fuj., R.K., H.W.), Sportology Center (Y.T., S.K., R.Y., M.Ki., K.S., H.D., S.A., R.K., H.W.), Department of Cardiology (M.N.-Y., K.S., H.D.), Department of Radiology (S.A.), Laboratory of Proteomics and Biomolecular Science, Research Support Center (H.T., T.Fuj.), Center for Therapeutic Innovations in Diabetes (H.W.), and Center for Molecular Diabetology (H.W.), Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan; Department of Health Promotion and Exercise (S.S.S.), National Institute of Health and Nutrition, Tokyo 162-8636, Japan; and Departments of Physiology and Medicine (A.G.), Institute of Medical Science and Banting and Best Diabetes Centre, University of Toronto, Toronto, ON M5G 2C4, Canada.
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Watada
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000328:Adult; D015992:Body Mass Index; D006801:Humans; D007333:Insulin Resistance; D007564:Japan; D008099:Liver / Q000378:metabolism*; D008297:Male; D024821:Metabolic Syndrome / Q000378:metabolism*; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism*