title: A new novolimus-eluting bioresorbable scaffold for large coronary arteries: an OCT study of acute mechanical performance.
abstract: OBJECTIVE
  To evaluate the acute performance of a novolimus-eluting bioresorbable scaffold (BRS) with a nominal diameter of 4.0mm (DESolve® XL) using optical coherence tomography (OCT) in terms of appropriate scaffold deployment.
  
  
  RESULTS
  Ten patients (55.6% male, mean age 60.0 y) undergoing OCT-guided scaffold implantation were enrolled consecutively in this retrospective study. Using data from the final pullback, the following indexes were calculated: mean and minimum area, residual area stenosis, incomplete strut apposition, tissue prolapse, eccentricity and symmetry indexes, strut fracture, and edge dissection. The clinical indication for the procedure was acute coronary syndrome in roughly half (55.5%) of the cases. All three main vessels were affected equally. The maximum post-dilatation balloon inflation pressure was 14.7±4.2atm. OCT analysis showed a lumen area of 11.4±1.9mm(2) and a scaffold area of 11.5±2.1mm(2). Mean residual area stenosis was 28.6%. No strut fractures or edge dissections were apparent. The mean eccentricity index was 0.65±0.16 and the mean symmetry index 0.39±0.25.
  
  
  CONCLUSIONS
  The size of large vessels does not adversely influence acute mechanical performance as assessed by the eccentricity and symmetry indexes. No adverse cardiac event occurred during the hospital stay or the 30-day follow-up. It is feasible to treat large vessels with the DESolve® XL BRS.
authors.affiliation: University of Giessen, Department of Cardiology, Germany.
authors.forename: Niklas F
authors.initials: NF
authors.lastname: Boeder
authors.affiliation: University of Giessen, Department of Cardiology, Germany.
authors.forename: Tim
authors.initials: T
authors.lastname: Koepp
authors.affiliation: University of Giessen, Department of Cardiology, Germany.
authors.forename: Oliver
authors.initials: O
authors.lastname: Dörr
authors.affiliation: University of Giessen, Department of Cardiology, Germany.
authors.forename: Timm
authors.initials: T
authors.lastname: Bauer
authors.affiliation: Interventional Cardiology Unit, Heart and Vessels department, Careggi Hospital, Florence, Italy.
authors.forename: Alessio
authors.initials: A
authors.lastname: Mattesini
authors.affiliation: Klinikum Oldenburg, Department of Cardiology, Germany.
authors.forename: Albrecht
authors.initials: A
authors.lastname: Elsässer
authors.affiliation: Kerckhoff Klinik Bad Nauheim, Department of Cardiology, Germany.
authors.forename: Helge
authors.initials: H
authors.lastname: Möllmann
authors.affiliation: University of Erlangen, Department of Cardiology, Germany.
authors.forename: Florian
authors.initials: F
authors.lastname: Blachutzik
authors.affiliation: University of Erlangen, Department of Cardiology, Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Achenbach
authors.affiliation: Asklepios Klinik St. Georg, Department of Cardiology, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Ghanem
authors.affiliation: University of Giessen, Department of Cardiology, Germany.
authors.forename: Christian W
authors.initials: CW
authors.lastname: Hamm
authors.affiliation: University of Giessen, Department of Cardiology, Germany. Electronic address: holger.nef@me.com.
authors.forename: Holger M
authors.initials: HM
authors.lastname: Nef
mesh_terms: D020341:Absorbable Implants; D000328:Adult; D000368:Aged; D001696:Biomechanical Phenomena / Q000502:physiology; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000601:surgery; D003331:Coronary Vessels / Q000000981:diagnostic imaging* / Q000601:surgery; D054855:Drug-Eluting Stents; D005260:Female; D006801:Humans; D018942:Macrolides / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention / Q000379:methods; D012189:Retrospective Studies; D054457:Tissue Scaffolds; D041623:Tomography, Optical Coherence / Q000379:methods*
chemical_list: D018942:Macrolides; C534800:novolimus
keywords: Large coronaries; Novolimus-eluting scaffold; Optical coherence tomography