title: [Use of levosimendan in children].
abstract: Levosimendan is a calcium-sensitizing drug with positive inotropic properties. As an inodilator, this molecule also has a vasodilation effect. While its efficacy has been demonstrated in the adult in the context of cardiac surgery, its pediatric use is still not widespread. Many studies have shown its safety of use in children, including in the newborn. Across the world, a growing number of teams use levosimendan to treat both acute and chronic heart failure. Through a review of the literature, we describe its pharmacodynamic effects, its current applications, and its perspectives of use in children.
authors.affiliation: Service de cardiologie pédiatrique et congénitale, hôpital Haut-Lévèque, CHU de Bordeaux, avenue de Magellan, 33604 Pessac cedex, France; Service de réanimation chirurgicale des cardiopathies congénitales, hôpital Haut-Lévèque, CHU de Bordeaux, avenue de Magellan, 33604 Pessac, France. Electronic address: peseguela@yahoo.fr.
authors.forename: P-E
authors.initials: PE
authors.lastname: Séguéla
authors.affiliation: Service de réanimation chirurgicale des cardiopathies congénitales, hôpital Haut-Lévèque, CHU de Bordeaux, avenue de Magellan, 33604 Pessac, France.
authors.forename: N
authors.initials: N
authors.lastname: Tafer
authors.affiliation: Service de cardiologie pédiatrique et congénitale, hôpital Haut-Lévèque, CHU de Bordeaux, avenue de Magellan, 33604 Pessac cedex, France.
authors.forename: J-B
authors.initials: JB
authors.lastname: Thambo
authors.affiliation: Service de réanimation chirurgicale des cardiopathies congénitales, hôpital Haut-Lévèque, CHU de Bordeaux, avenue de Magellan, 33604 Pessac, France.
authors.forename: P
authors.initials: P
authors.lastname: Mauriat
mesh_terms: D002303:Cardiac Output, Low / Q000188:drug therapy; D002316:Cardiotonic Agents / Q000494:pharmacology*; D002648:Child; D005112:Extracorporeal Circulation; D006333:Heart Failure / Q000188:drug therapy; D006801:Humans; D006835:Hydrazones / Q000494:pharmacology*; D011183:Postoperative Complications / Q000188:drug therapy; D011724:Pyridazines / Q000494:pharmacology*; D000077464:Simendan
chemical_list: D002316:Cardiotonic Agents; D006835:Hydrazones; D011724:Pyridazines; D000077464:Simendan