title: The Pathology of Alcoholic Liver Disease.
abstract: The term "alcoholic liver disease" encompasses a spectrum of pathologic conditions ranging from isolated steatosis to established cirrhosis. Within this spectrum, varying degrees of inflammation, hepatocellular ballooning degeneration, hepatocyte necrosis, cholestasis, and fibrosis may be encountered. This article reviews the characteristic histologic features of the many forms of alcoholic liver disease. Histologic scoring systems are described, and diseases with overlapping morphologic features and comorbid conditions are also discussed.
authors.affiliation: Department of Pathology, The University of Chicago, 5841 South Maryland Avenue, MC 6101, Chicago, IL 60637, USA. Electronic address: Lindsay.Alpert@uchospitals.edu.
authors.forename: Lindsay
authors.initials: L
authors.lastname: Alpert
authors.affiliation: Department of Pathology, The University of Chicago, 5841 South Maryland Avenue, MC 6101, Chicago, IL 60637, USA.
authors.forename: John
authors.initials: J
authors.lastname: Hart
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000473:pathology; D015897:Comorbidity; D003937:Diagnosis, Differential; D005235:Fatty Liver, Alcoholic / Q000473:pathology; D006519:Hepatitis, Alcoholic / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D008104:Liver Cirrhosis, Alcoholic / Q000473:pathology; D008108:Liver Diseases, Alcoholic / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*; D008113:Liver Neoplasms / Q000473:pathology; D065626:Non-alcoholic Fatty Liver Disease / Q000473:pathology
keywords: Alcoholic steatohepatitis; Ballooning degeneration; Cholestasis; Cirrhosis; Sinusoidal fibrosis; Steatosis