title: Effects of Vascular Peptide Bioregulator on the Density of Microvascular Network in the Brain Cortex of Aged Rats.
abstract: Using a TV unit for microcirculation studies, we studied the density of the entire microvascular network and its arterial compartment in the pia mater of the sensorimotor cortex in intact young and aged rats (2-3 and 22-24 months) and aged rats after a course of vascular peptide bioregulator Slavinorm. The experiments showed that the density of microvascular network in intact animals decreased by 1.6 times with aging. Treatment with the peptide bioregulator 2.5-fold increased the density of the microvascular network in aged rats in comparison with intact animals of the same age, the density of the arterial compartment of the microvascular network in the pia mater increased by 2.8 times.
authors.affiliation: I. P. Pavlov Institute of Physiology, the Russian Academy of Sciences, St. Petersburg, Russia. sib@kolt.infran.ru.
authors.forename: I B
authors.initials: IB
authors.lastname: Sokolova
authors.affiliation: St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia.
authors.forename: G A
authors.initials: GA
authors.lastname: Ryzhak
authors.affiliation: I. P. Pavlov Institute of Physiology, the Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: N N
authors.initials: NN
authors.lastname: Mel'nikova
authors.affiliation: I. P. Pavlov Institute of Physiology, the Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Sergeev
authors.affiliation: St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia.
authors.forename: V Kh
authors.initials: VKh
authors.lastname: Khavinson
mesh_terms: D000375:Aging; D043925:Angiogenesis Inducing Agents / Q000494:pharmacology*; D000818:Animals; D004353:Drug Evaluation, Preclinical; D008297:Male; D055806:Microvessels / Q000187:drug effects*; D018919:Neovascularization, Physiologic / Q000187:drug effects; D010841:Pia Mater / Q000098:blood supply*; D011506:Proteins / Q000494:pharmacology*; D011921:Rats, Inbred WKY; D066191:Sensorimotor Cortex / Q000098:blood supply*
chemical_list: D043925:Angiogenesis Inducing Agents; D011506:Proteins
keywords: angiogenesis; arteriogenesis; brain; microvascular network density; vascular peptide bioregulator