title: Store-operated Ca2+ channels in airway epithelial cell function and implications for asthma.
abstract: The epithelial cells of the lung are at the interface of a host and its environment and are therefore directly exposed to the inhaled air-borne particles. Rather than serving as a simple physical barrier, airway epithelia detect allergens and other irritants and then help organize the subsequent immune response through release of a plethora of secreted signals. Many of these signals are generated in response to opening of store-operated Ca(2+) channels in the plasma membrane. In this review, we describe the properties of airway store-operated channels and their role in regulating airway epithelial cell function.This article is part of the themed issue 'Evolution brings Ca(2+) and ATP together to control life and death'.
authors.affiliation: Department of Physiology, Anatomy and Genetics, Sherrington Building, Parks Road, Oxford OX1 3PT, UK.
authors.forename: Krishna
authors.initials: K
authors.lastname: Samanta
authors.affiliation: Department of Physiology, Anatomy and Genetics, Sherrington Building, Parks Road, Oxford OX1 3PT, UK anant.parekh@dpag.ox.ac.uk.
authors.forename: Anant B
authors.initials: AB
authors.lastname: Parekh
mesh_terms: D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism*; D020013:Calcium Signaling; D004847:Epithelial Cells / Q000378:metabolism; D006801:Humans; D008168:Lung / Q000378:metabolism*
chemical_list: D015220:Calcium Channels; D002118:Calcium
keywords: Ca2+ signalling; airway epithelia; store-operated Ca2+ channel