title: Value of patient-reported symptoms in the diagnosis of transient loss of consciousness.
abstract: OBJECTIVE
  Epileptic seizures, syncope, and psychogenic nonepileptic seizures (PNES) account for over 90% of presentations with transient loss of consciousness (TLOC). The patient's history is crucial for the diagnosis, but the diagnostic value of individual semiologic features is limited. This study explores the diagnostic potential of a comprehensive questionnaire focusing on TLOC-associated symptoms.
  
  
  METHODS
  A total of 386 patients with proven epilepsy, 308 patients with proven PNES, and 371 patients with proven syncope were approached by post to recruit 100 patients in each diagnostic group. Symptoms were self-reported on an 86-item questionnaire (the Paroxysmal Event Profile [PEP]) using a 5-point Likert scale (always to never). Data were subjected to exploratory factor analysis (EFA) followed by confirmatory factor analysis (CFA). Factors were used to differentiate between diagnoses by pairwise and multinomial regression.
  
  
  RESULTS
  Patients with PNES reported more and more frequent TLOC-associated symptoms than those with epilepsy or syncope (p < 0.001). EFA/CFA identified a 5-factor structure based on 74/86 questionnaire items with loadings ≥0.4. Pairwise logistic regression analysis correctly classified 91% of patients with epilepsy vs those with syncope, 94% of those with PNES vs those with syncope, and 77% of those with epilepsy vs those with PNES. Multinomial logistic regression analysis yielded a similar pattern.
  
  
  CONCLUSIONS
  Clusters of self-reported TLOC symptoms can be used to direct patients to appropriate investigation and treatment pathways for syncope on the one hand and seizures on the other, although additional information is required for a reliable distinction, especially between epilepsy and PNES.
authors.affiliation: From the Academic Neurology Unit (M.R., J.J.-K.), Royal Hallamshire Hospital, University of Sheffield, UK; Gertrude H. Sergievsky Center (M.C., M. Wall, D.H.), Columbia University, New York, NY; Mental Health Liaison Team (M.B.), Derbyshire Healthcare NHS Foundation Trust Hartington Unit, Chesterfield; Department of Neurology (R.A.G., S.J.H.), Sheffield Teaching Hospitals NHS Foundation Trust; Department of Clinical and Experimental Epilepsy (M.K., S.S., M. Walker), University College London, Institute of Neurology; and Institute of Cellular Medicine (S.P.), Newcastle University, UK. m.reuber@sheffield.ac.uk.
authors.forename: Markus
authors.initials: M
authors.lastname: Reuber
authors.affiliation: From the Academic Neurology Unit (M.R., J.J.-K.), Royal Hallamshire Hospital, University of Sheffield, UK; Gertrude H. Sergievsky Center (M.C., M. Wall, D.H.), Columbia University, New York, NY; Mental Health Liaison Team (M.B.), Derbyshire Healthcare NHS Foundation Trust Hartington Unit, Chesterfield; Department of Neurology (R.A.G., S.J.H.), Sheffield Teaching Hospitals NHS Foundation Trust; Department of Clinical and Experimental Epilepsy (M.K., S.S., M. Walker), University College London, Institute of Neurology; and Institute of Cellular Medicine (S.P.), Newcastle University, UK.
authors.forename: Min
authors.initials: M
authors.lastname: Chen
authors.affiliation: From the Academic Neurology Unit (M.R., J.J.-K.), Royal Hallamshire Hospital, University of Sheffield, UK; Gertrude H. Sergievsky Center (M.C., M. Wall, D.H.), Columbia University, New York, NY; Mental Health Liaison Team (M.B.), Derbyshire Healthcare NHS Foundation Trust Hartington Unit, Chesterfield; Department of Neurology (R.A.G., S.J.H.), Sheffield Teaching Hospitals NHS Foundation Trust; Department of Clinical and Experimental Epilepsy (M.K., S.S., M. Walker), University College London, Institute of Neurology; and Institute of Cellular Medicine (S.P.), Newcastle University, UK.
authors.forename: Jenny
authors.initials: J
authors.lastname: Jamnadas-Khoda
authors.affiliation: From the Academic Neurology Unit (M.R., J.J.-K.), Royal Hallamshire Hospital, University of Sheffield, UK; Gertrude H. Sergievsky Center (M.C., M. Wall, D.H.), Columbia University, New York, NY; Mental Health Liaison Team (M.B.), Derbyshire Healthcare NHS Foundation Trust Hartington Unit, Chesterfield; Department of Neurology (R.A.G., S.J.H.), Sheffield Teaching Hospitals NHS Foundation Trust; Department of Clinical and Experimental Epilepsy (M.K., S.S., M. Walker), University College London, Institute of Neurology; and Institute of Cellular Medicine (S.P.), Newcastle University, UK.
authors.forename: Mark
authors.initials: M
authors.lastname: Broadhurst
authors.affiliation: From the Academic Neurology Unit (M.R., J.J.-K.), Royal Hallamshire Hospital, University of Sheffield, UK; Gertrude H. Sergievsky Center (M.C., M. Wall, D.H.), Columbia University, New York, NY; Mental Health Liaison Team (M.B.), Derbyshire Healthcare NHS Foundation Trust Hartington Unit, Chesterfield; Department of Neurology (R.A.G., S.J.H.), Sheffield Teaching Hospitals NHS Foundation Trust; Department of Clinical and Experimental Epilepsy (M.K., S.S., M. Walker), University College London, Institute of Neurology; and Institute of Cellular Medicine (S.P.), Newcastle University, UK.
authors.forename: Melanie
authors.initials: M
authors.lastname: Wall
authors.affiliation: From the Academic Neurology Unit (M.R., J.J.-K.), Royal Hallamshire Hospital, University of Sheffield, UK; Gertrude H. Sergievsky Center (M.C., M. Wall, D.H.), Columbia University, New York, NY; Mental Health Liaison Team (M.B.), Derbyshire Healthcare NHS Foundation Trust Hartington Unit, Chesterfield; Department of Neurology (R.A.G., S.J.H.), Sheffield Teaching Hospitals NHS Foundation Trust; Department of Clinical and Experimental Epilepsy (M.K., S.S., M. Walker), University College London, Institute of Neurology; and Institute of Cellular Medicine (S.P.), Newcastle University, UK.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Grünewald
authors.affiliation: From the Academic Neurology Unit (M.R., J.J.-K.), Royal Hallamshire Hospital, University of Sheffield, UK; Gertrude H. Sergievsky Center (M.C., M. Wall, D.H.), Columbia University, New York, NY; Mental Health Liaison Team (M.B.), Derbyshire Healthcare NHS Foundation Trust Hartington Unit, Chesterfield; Department of Neurology (R.A.G., S.J.H.), Sheffield Teaching Hospitals NHS Foundation Trust; Department of Clinical and Experimental Epilepsy (M.K., S.S., M. Walker), University College London, Institute of Neurology; and Institute of Cellular Medicine (S.P.), Newcastle University, UK.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Howell
authors.affiliation: From the Academic Neurology Unit (M.R., J.J.-K.), Royal Hallamshire Hospital, University of Sheffield, UK; Gertrude H. Sergievsky Center (M.C., M. Wall, D.H.), Columbia University, New York, NY; Mental Health Liaison Team (M.B.), Derbyshire Healthcare NHS Foundation Trust Hartington Unit, Chesterfield; Department of Neurology (R.A.G., S.J.H.), Sheffield Teaching Hospitals NHS Foundation Trust; Department of Clinical and Experimental Epilepsy (M.K., S.S., M. Walker), University College London, Institute of Neurology; and Institute of Cellular Medicine (S.P.), Newcastle University, UK.
authors.forename: Matthias
authors.initials: M
authors.lastname: Koepp
authors.affiliation: From the Academic Neurology Unit (M.R., J.J.-K.), Royal Hallamshire Hospital, University of Sheffield, UK; Gertrude H. Sergievsky Center (M.C., M. Wall, D.H.), Columbia University, New York, NY; Mental Health Liaison Team (M.B.), Derbyshire Healthcare NHS Foundation Trust Hartington Unit, Chesterfield; Department of Neurology (R.A.G., S.J.H.), Sheffield Teaching Hospitals NHS Foundation Trust; Department of Clinical and Experimental Epilepsy (M.K., S.S., M. Walker), University College London, Institute of Neurology; and Institute of Cellular Medicine (S.P.), Newcastle University, UK.
authors.forename: Steve
authors.initials: S
authors.lastname: Parry
authors.affiliation: From the Academic Neurology Unit (M.R., J.J.-K.), Royal Hallamshire Hospital, University of Sheffield, UK; Gertrude H. Sergievsky Center (M.C., M. Wall, D.H.), Columbia University, New York, NY; Mental Health Liaison Team (M.B.), Derbyshire Healthcare NHS Foundation Trust Hartington Unit, Chesterfield; Department of Neurology (R.A.G., S.J.H.), Sheffield Teaching Hospitals NHS Foundation Trust; Department of Clinical and Experimental Epilepsy (M.K., S.S., M. Walker), University College London, Institute of Neurology; and Institute of Cellular Medicine (S.P.), Newcastle University, UK.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Sisodiya
authors.affiliation: From the Academic Neurology Unit (M.R., J.J.-K.), Royal Hallamshire Hospital, University of Sheffield, UK; Gertrude H. Sergievsky Center (M.C., M. Wall, D.H.), Columbia University, New York, NY; Mental Health Liaison Team (M.B.), Derbyshire Healthcare NHS Foundation Trust Hartington Unit, Chesterfield; Department of Neurology (R.A.G., S.J.H.), Sheffield Teaching Hospitals NHS Foundation Trust; Department of Clinical and Experimental Epilepsy (M.K., S.S., M. Walker), University College London, Institute of Neurology; and Institute of Cellular Medicine (S.P.), Newcastle University, UK.
authors.forename: Matthew
authors.initials: M
authors.lastname: Walker
authors.affiliation: From the Academic Neurology Unit (M.R., J.J.-K.), Royal Hallamshire Hospital, University of Sheffield, UK; Gertrude H. Sergievsky Center (M.C., M. Wall, D.H.), Columbia University, New York, NY; Mental Health Liaison Team (M.B.), Derbyshire Healthcare NHS Foundation Trust Hartington Unit, Chesterfield; Department of Neurology (R.A.G., S.J.H.), Sheffield Teaching Hospitals NHS Foundation Trust; Department of Clinical and Experimental Epilepsy (M.K., S.S., M. Walker), University College London, Institute of Neurology; and Institute of Cellular Medicine (S.P.), Newcastle University, UK.
authors.forename: Dale
authors.initials: D
authors.lastname: Hesdorffer
mesh_terms: D000328:Adult; D002648:Child; D004827:Epilepsy / Q000150:complications / Q000175:diagnosis; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012640:Seizures / Q000150:complications / Q000175:diagnosis; D057566:Self Report; D011795:Surveys and Questionnaires; D013575:Syncope / Q000150:complications / Q000175:diagnosis; D014474:Unconsciousness / Q000150:complications / Q000175:diagnosis*