title: The efficacy of intravenous hyoscine-N-butylbromide during colonoscopy: a prospective, randomized, double-blind, placebo-controlled study.
abstract: BACKGROUND
  Colonic spasm makes colonoscope advancement difficult. This prospective, randomized, double-blind, placebo-controlled study aimed to evaluate the efficacy of hyoscine-N-butylbromide as an antispasmodic during colonoscopy.
  
  
  METHODS
  Patients referred for elective colonoscopy were randomized into the study and placebo groups. Before the procedure, the study and placebo groups received 20 mg intra-venous hyoscine-N-butylbromide and intravenous saline solution of the same amount, respectively. Demographic and procedure--related data were recorded and compared between the groups.
  
  
  RESULTS
  Of 198 patients referred for elective colonoscopy, 121 were included (study group = 60, placebo group = 61). No differences were observed between the study and placebo groups in terms of demographic data, pre-procedure characteristics, and colonoscopic characteristics including the cecal intubation time, total procedure time, bowel preparation, sedation doses, hemo-dynamic findings, endoscopist satisfaction, patient comfort, and polyp detection rate. The only difference was an increase in the heart rate by 32% in the study group after hyoscine-N-butyl-bromide administration (p < 0.001).
  
  
  CONCLUSIONS
  Hyoscine-N-butylbromide did not reduce the time to reach the cecum and the total colonoscopy time, and patient and endoscopist satisfaction and polyp detection rate did not change. Furthermore, it was concluded that hyoscine-N-butylbromide can increase the risk of drug-related complications.
authors.forename: B
authors.initials: B
authors.lastname: Dinc
authors.forename: U R
authors.initials: UR
authors.lastname: Gunduz
authors.forename: B
authors.initials: B
authors.lastname: Bas
authors.forename: N
authors.initials: N
authors.lastname: Ay
authors.forename: U
authors.initials: U
authors.lastname: Koc
authors.forename: O Z
authors.initials: OZ
authors.lastname: Oner
authors.forename: I
authors.initials: I
authors.lastname: Gomceli
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002086:Butylscopolammonium Bromide / Q000627:therapeutic use*; D003092:Colitis / Q000175:diagnosis; D003110:Colonic Neoplasms / Q000175:diagnosis; D003111:Colonic Polyps / Q000175:diagnosis; D003113:Colonoscopy / Q000379:methods*; D004241:Diverticulum, Colon / Q000175:diagnosis; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D061646:Operative Time; D010276:Parasympatholytics / Q000627:therapeutic use*; D011292:Premedication / Q000379:methods*; D013035:Spasm / Q000517:prevention & control*; D055815:Young Adult
chemical_list: D010276:Parasympatholytics; D002086:Butylscopolammonium Bromide