title: Patterns of striatal functional connectivity differ in early and late onset Parkinson's disease.
abstract: To map functional connectivity (FC) patterns of early onset Parkinson's disease (EOPD) and late onset PD (LOPD) in drug-naïve early stage. MRI was used to assess atrophy and resting-state FC focusing on striatal subregions of EOPD and LOPD in two subgroups of 18 patients matched for disease duration and severity, relative to age- and sex- matched healthy controls. Compared with controls, both PD subgroups showed FC alterations in cortico-striatal and cerebello-striatal loops but with different patterns in resting state. EOPD patients showed widespread increased FC between striatum and sensorimotor cortex, middle frontal gyrus, superior and inferior parietal lobules, superior and inferior temporal gyri, and cerebellum. While LOPD patients were evidenced with increased FC in cerebello-striatal circuit and decreased FC between orbitofrontal gyrus and striatum. In addition, Unified Parkinson's Disease Rating Scale part III scores were negatively correlated with the increased FC between the caudate nucleus and sensorimotor cortex (r = -0.571, p = 0.013) in EOPD patients, while negatively correlated with the increased FC between the putamen and cerebellum (r = -0.478, p = 0.045) in LOPD patients, suggesting that increased FC is here likely to reflect compensatory mechanism. FC changes in EOPD and LOPD share common features and have differences, which may suggest that the responses to defective basal ganglia are different between the two subtypes. Improved insights into the onset-related subtypes of PD and its disruptive FC pattern will be valuable for improving our understanding of the pathogenesis of the disease.
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
authors.forename: Yanbing
authors.initials: Y
authors.lastname: Hou
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Luo
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
authors.forename: Ruwei
authors.initials: R
authors.lastname: Ou
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Song
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
authors.forename: Wanglin
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Radiology, Huaxi MR Research Center (HMRRC), West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China. huaxigong@126.com.
authors.forename: Qiyong
authors.initials: Q
authors.lastname: Gong
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China. hfshang2002@126.com.
authors.forename: Huifang
authors.initials: H
authors.lastname: Shang
mesh_terms: D000328:Adult; D017668:Age of Onset; D001931:Brain Mapping; D016022:Case-Control Studies; D016000:Cluster Analysis; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000502:physiology*; D010300:Parkinson Disease / Q000000981:diagnostic imaging / Q000473:pathology*; D012720:Severity of Illness Index; D013223:Statistics as Topic
keywords: Early onset Parkinson’s disease; Functional MRI; Functional connectivity; Late onset Parkinson’s disease; Parkinson’s disease