title: Iodine(III)-Catalyzed Cascade Reactions Enabling a Direct Access to β-Lactams and α-Hydroxy-β-amino Acids.
abstract: In the presented method, a one-pot metal-free access to β-lactams is provided. The developed strategy employs a hypervalent iodine(III)-triggered bromination/rearrangement/cyclization cascade reaction that allows the straightforward synthesis of a broad range of structurally different lactams from cheap and easily available imides. This triple cascade reaction is furthermore extendable by an in situ ring-opening reaction, giving direct access to isoserine derivatives from simple imines in a four-step, one-pot reaction.
authors.affiliation: Department of Chemistry and Catalysis Research Center (CRC), Technical University of Munich , Lichtenbergstrasse 4, 85747 Garching, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Patzelt
authors.affiliation: Department of Chemistry and Catalysis Research Center (CRC), Technical University of Munich , Lichtenbergstrasse 4, 85747 Garching, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Pöthig
authors.affiliation: Department of Chemistry and Catalysis Research Center (CRC), Technical University of Munich , Lichtenbergstrasse 4, 85747 Garching, Germany.
authors.forename: Tanja
authors.initials: T
authors.lastname: Gulder