title: The umami taste: from discovery to clinical use.
abstract: In the diversity of the flavor world only five basic tastes have been described. The newest one, umami, has been identified about one hundred years ago by Kikunae Ikeda but widely accepted just in the second half of the twentieth century by international scientific world. There are three umami substances: monosodium glutamate (MSG), inosine-5'-monophosphate (IMP), guanylo-5'-monophosphate (GMP). A real breakthrough in umami history concerned the finding about independent receptors for umami: T1R1 and T1R3 (taste receptors type 1 member 1 and member 3). The palatable, delicious taste of umami and its mechanism determined a lot of research studies on this highlight. Umami substances elicit salivary secretion, enhance appetite and increase food palatability. They are desirable to improve the quality of diet. Moreover, the association between umami substances and the suppression of obesity has been found. Studies suggest that umami is engaged in metabolism but also increases satiety and reduces the post-ingestive recovery of hunger.
authors.affiliation: Klinika Otorynolaryngologii, Wydział Lekarsko-Dentystyczny Warszawski Uniwersytet Medyczny. Szpital Czerniakowski ul. Stępińska 19/25 00-739 Warszawa / Department of Otorhinolaryngology, Medical University of Warsaw, 19/25 Stepinska Street, 00-739 Warsaw.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Stańska
authors.affiliation: Klinika Otorynolaryngologii, Wydział Lekarsko-Dentystyczny Warszawski Uniwersytet Medyczny. Szpital Czerniakowski ul. Stępińska 19/25 00-739 Warszawa / Department of Otorhinolaryngology, Medical University of Warsaw, 19/25 Stepinska Street, 00-739 Warsaw.
authors.forename: Antonii
authors.initials: A
authors.lastname: Krzeski
mesh_terms: D019167:Appetite Stimulants / Q000378:metabolism; D005247:Feeding Behavior; D005421:Flavoring Agents / Q000378:metabolism*; D005503:Food Additives / Q000378:metabolism*; D006157:Guanosine Monophosphate / Q000378:metabolism*; D006801:Humans; D007291:Inosine Monophosphate / Q000378:metabolism*; D012970:Sodium Glutamate / Q000378:metabolism*; D013649:Taste / Q000187:drug effects; D013650:Taste Buds / Q000502:physiology*; D014059:Tongue / Q000502:physiology
chemical_list: D019167:Appetite Stimulants; D005421:Flavoring Agents; D005503:Food Additives; D007291:Inosine Monophosphate; D006157:Guanosine Monophosphate; D012970:Sodium Glutamate