title: Formation of N-(1-Oxo-2,4,5,6-hydroxyhexyl)-2'-deoxyguanosine by the Reaction of 2'-Deoxyguanosine with 3-Deoxyglucosone.
abstract: 3-Deoxyglucosone (3DG) has weaker mutagenicity than methylglyoxal by the Ames test. 3DG reacted readily with 2'-deoxyguanosine (dG) in nucleosides. Two major products (G-A and G-B) were isolated and purified from the reaction mixture of 50 mM 3DG and 50 mM dG at 50°C and pH 7.4 for 6d. G-A was identified as N-(1-oxo-2,4,5,6-hydroxyhexyl)-2'-deoxyguanosine. G-B was identified as a diastereomer of G-A.
authors.affiliation: a Department of Agricultural Chemistry, Meiji University.
authors.forename: F
authors.initials: F
authors.lastname: Hayase
authors.affiliation: a Department of Agricultural Chemistry, Meiji University.
authors.forename: K
authors.initials: K
authors.lastname: Kaneko
keywords: 2′-deoxyguanosine; 3-deoxyglucosone; Maillard reaction; methylglyoxal; nucleosides