title: Multicomponent Combinatorial Polymerization via the Biginelli Reaction.
abstract: A multicomponent combinatorial polymerization method has been exploited as a new intersection between combinatorial chemistry, polymer chemistry, and organic chemistry. The tricomponent Biginelli reaction has been employed as a model multicomponent reaction (MCR) to efficiently prepare a library of polycondensates with continuously changed chain structure but different physical properties. The naturally increased reaction modules (monomers) directly doubled the number of polymers in the library, effectively improving the efficiency of polymer preparation. The glass transition temperatures (Tg) of those homologous polymers have been mapped for the first time to predict the Tg values of absent polymer homologues with good to excellent accuracy. Meanwhile, the Tg maps have also been used to reveal the regular change in Tg according to the polymer structure (linking group, monomer chain length, etc.), initially suggesting the academic significance of the multicomponent combinatorial polymerization system. We believe that the current research paves a straightforward way to synthesize new libraries of polymers via MCRs and might prompt the broader study of MCRs in interdisciplinary fields.
authors.affiliation: The Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University , Beijing 100084, P. R. China.|School of Petrochemical Engineering, Changzhou University , Changzhou, Jiangsu 213164, China.
authors.forename: Haodong
authors.initials: H
authors.lastname: Xue
authors.affiliation: The Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University , Beijing 100084, P. R. China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: The Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University , Beijing 100084, P. R. China.|School of Petrochemical Engineering, Changzhou University , Changzhou, Jiangsu 213164, China.
authors.forename: Haibo
authors.initials: H
authors.lastname: Wu
authors.affiliation: The Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University , Beijing 100084, P. R. China.
authors.forename: Zilin
authors.initials: Z
authors.lastname: Wang
authors.affiliation: The Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University , Beijing 100084, P. R. China.
authors.forename: Bin
authors.initials: B
authors.lastname: Yang
authors.affiliation: The Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University , Beijing 100084, P. R. China.
authors.forename: Yen
authors.initials: Y
authors.lastname: Wei
authors.affiliation: School of Petrochemical Engineering, Changzhou University , Changzhou, Jiangsu 213164, China.
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Wang
authors.affiliation: The Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University , Beijing 100084, P. R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Tao