title: Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards.
abstract: Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions of MDSC to tumour progression through both immune-mediated mechanisms and those not directly associated with immune suppression. MDSC are the subject of intensive research with >500 papers published in 2015 alone. However, the phenotypic, morphological and functional heterogeneity of these cells generates confusion in investigation and analysis of their roles in inflammatory responses. The purpose of this communication is to suggest characterization standards in the burgeoning field of MDSC research.
authors.affiliation: Department of Medicine, University Hospital, University of Verona, Verona 37134, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Bronte
authors.affiliation: Department of Otorhinolaryngology, University Hospital Essen, Essen D-45122, Germany.
authors.forename: Sven
authors.initials: S
authors.lastname: Brandau
authors.affiliation: Department of Oncological Sciences, Tisch Cancer Institute, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
authors.forename: Shu-Hsia
authors.initials: SH
authors.lastname: Chen
authors.affiliation: Department of Experimental Oncology and Molecular Medicine, Molecular Immunology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano 20133, Italy.
authors.forename: Mario P
authors.initials: MP
authors.lastname: Colombo
authors.affiliation: New York University School of Medicine, New York, New York 10029, USA.
authors.forename: Alan B
authors.initials: AB
authors.lastname: Frey
authors.affiliation: GI-Malignancy Section, Thoracic and GI Oncology Branch, NCI, Bethesda, Maryland 20892, USA.
authors.forename: Tim F
authors.initials: TF
authors.lastname: Greten
authors.affiliation: Department of Surgery, Oncology and Gastroenterology, Section of Oncology and Immunology, University of Padova, Padova 35128, Italy.|Veneto Institute of Oncology IOV-IRCCS, Padova 35128, Italy.
authors.forename: Susanna
authors.initials: S
authors.lastname: Mandruzzato
authors.affiliation: Departments of Infectious Diseases and Immunology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Murray
authors.affiliation: Stanley S. Scott Cancer Center, Louisiana State University, New Orleans, Louisiana 70112, USA.
authors.forename: Augusto
authors.initials: A
authors.lastname: Ochoa
authors.affiliation: University of Maryland Baltimore County, Baltimore, Maryland 21250, USA.
authors.forename: Suzanne
authors.initials: S
authors.lastname: Ostrand-Rosenberg
authors.affiliation: Georgia Regents University Cancer Center, Augusta, Georgia 30912, USA.
authors.forename: Paulo C
authors.initials: PC
authors.lastname: Rodriguez
authors.affiliation: Humanitas Clinical and Research Center, Via Manzoni 56, Rozzano, Milan 20089, Italy.|Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', via Bovio 6, Novara 20089, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Sica
authors.affiliation: Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.|Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim 69120, Germany.
authors.forename: Viktor
authors.initials: V
authors.lastname: Umansky
authors.affiliation: Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.
authors.forename: Robert H
authors.initials: RH
authors.lastname: Vonderheide
authors.affiliation: Translational Tumor Immunology, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
authors.forename: Dmitry I
authors.initials: DI
authors.lastname: Gabrilovich
mesh_terms: D000465:Algorithms; D000818:Animals; D015703:Antigens, CD / Q000276:immunology / Q000378:metabolism; D002454:Cell Differentiation / Q000276:immunology*; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D006801:Humans; D018448:Models, Immunological; D000072737:Myeloid-Derived Suppressor Cells / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D009369:Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D009626:Terminology as Topic
chemical_list: D015703:Antigens, CD; D016207:Cytokines