title: Long non-coding RNA-MIAT promotes neurovascular remodeling in the eye and brain.
abstract: Although nervous and vascular systems are functionally different, they usually share similar mechanisms for function maintenance. Neurovascular dysfunction has became the pathogenesis of several vascular and nervous disorders. Here we show that long non-coding RNA-MIAT is aberrantly expressed under neurovascular dysfunction condition. MIAT is shown as a regulator of vascular dysfunction, including retinal angiogenesis, corneal angiogenesis, and vascular permeability. MIAT is also shown as a regulator of retinal neurodegeneration under diabetic condition. Mechanistically, MIAT regulates neural and vascular cell function via MIAT/miR-150-5p/VEGF network. The eye is a valuable model to study central nervous system (CNS) disorders. We show that MIAT knockdown leads to cerebral microvascular degeneration, progressive neuronal loss and neurodegeneration, and behavioral deficits in a CNS neurovascular disorder, Alzheimer's disease. MIAT may represent a pharmacological target for treating neurovascular-related disorders.
authors.affiliation: Eye Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Jiang
authors.affiliation: Eye Hospital, Nanjing Medical University, Nanjing, China.|Research Center, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Shan
authors.affiliation: Eye Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Qun-Wang
authors.affiliation: Eye Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Rong-Mei
authors.initials: RM
authors.lastname: Zhou
authors.affiliation: Eye Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
authors.affiliation: Eye Hospital, Nanjing Medical University, Nanjing, China.|Research Center, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Chang
authors.initials: C
authors.lastname: Liu
authors.affiliation: Eye Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Yu-Jie
authors.initials: YJ
authors.lastname: Li
authors.affiliation: Eye Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Yao
authors.affiliation: Eye Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Xiu-Miao
authors.initials: XM
authors.lastname: Li
authors.affiliation: Eye Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Department of Neurology, Jiangsu Province Hospital, Nanjing, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Cheng
authors.affiliation: Department of Neurology, Jiangsu Chinese Medicine Hospital, Nanjing, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yuan
authors.affiliation: Department of Cardiac Surgery, The First School of Clinical Medicine, Nanjing Medical University, Nanjing, China.
authors.forename: Yang-Yang
authors.initials: YY
authors.lastname: Zhang
authors.affiliation: Research Center, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Biao
authors.initials: B
authors.lastname: Yan
mesh_terms: D000544:Alzheimer Disease / Q000473:pathology; D000818:Animals; D001921:Brain / Q000473:pathology; D002493:Central Nervous System Diseases / Q000473:pathology; D003921:Diabetes Mellitus, Experimental / Q000473:pathology; D004195:Disease Models, Animal; D008297:Male; D018782:Maze Learning; D051379:Mice; D008810:Mice, Inbred C57BL; D008833:Microcirculation; D009389:Neovascularization, Pathologic; D019636:Neurodegenerative Diseases / Q000473:pathology; D009457:Neuroglia / Q000473:pathology; D062085:RNA, Long Noncoding / Q000235:genetics*; D012160:Retina / Q000473:pathology*; D065854:Spatial Navigation; D066253:Vascular Remodeling
chemical_list: C517383:Miat long non-coding RNA; D062085:RNA, Long Noncoding
keywords: angiogenesis; long non-coding RNA; neurodegeneration; reactive glia