title: Chemoprevention of Keratinocyte Carcinomas: An Updated Review.
abstract: A well-established link between ultraviolet exposure and the carcinogenesis of keratinocyte carcinomas exists. Despite increased sun protection efforts, skin cancer remains the most common cancer in the USA. Numerous studies on the topic of chemoprevention investigate alternative topical, oral, and injectable agents to reduce skin cancer incidence in those at risk. Such agents include sunscreen, numerous vitamins and minerals, difluoromethylornithine, non-steroidal anti-inflammatory drugs, various peptides, field therapy, statins, and polyphenols. In this focused review, we discuss the risks and benefits of chemoprotective agents reported in clinical studies conducted in humans. We report several agents that may reduce skin cancer incidence in those at risk.
authors.affiliation: Stony Brook University School of Medicine, Stony Brook, NY, USA.|Department of Dermatology, University of Colorado Hospital, Aurora, CO, USA.
authors.forename: Jessica
authors.initials: J
authors.lastname: Mounessa
authors.affiliation: Duke University School of Medicine, 8 Duke University Medical Center Greenspace, Durham, NC, USA.
authors.forename: Rosie
authors.initials: R
authors.lastname: Qin
authors.affiliation: Department of Dermatology, University of Colorado Hospital, Aurora, CO, USA.|Department of Dermatology, Denver VA Medical Center, 1055 Clermont St. #165, Denver, CO, 80220, USA.
authors.forename: Cory A
authors.initials: CA
authors.lastname: Dunnick
authors.affiliation: Department of Dermatology, University of Colorado Hospital, Aurora, CO, USA. Robert.Dellavalle@ucdenver.edu.|Department of Dermatology, Denver VA Medical Center, 1055 Clermont St. #165, Denver, CO, 80220, USA. Robert.Dellavalle@ucdenver.edu.
authors.forename: Robert P
authors.initials: RP
authors.lastname: Dellavalle
mesh_terms: D002277:Carcinoma / Q000473:pathology / Q000517:prevention & control*; D018890:Chemoprevention / Q000009:adverse effects / Q000379:methods; D006801:Humans; D015603:Keratinocytes / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology / Q000517:prevention & control*; D014466:Ultraviolet Rays / Q000009:adverse effects