title: Adipose-Derived Mesenchymal Stem Cells Ameliorate Lipid Metabolic Disturbance in Mice.
abstract: : Adipose-derived mesenchymal stem cells (AD-MSCs) have been shown to ameliorate hyperglycemia in diabetic animals and individuals. However, little is known about whether AD-MSCs affect lipid metabolism. Here we have demonstrated for the first time that AD-MSC infusion can significantly suppress the increase in body weight and remarkably improve dyslipidemia in db/db obese mice and diet-induced obesity mice. Induction of white fat tissue "browning" and activation of adenosine monophosphate-activated protein kinase and its downstream hormone-sensitive lipase in adipose tissue contribute to the antiobesity and lipid-lowering effects. Thus, AD-MSC infusion holds great therapeutic potential for dyslipidemia and associated cardiovascular diseases.
  
  
  
  Mesenchymal stem cells (MSCs) are considered one of the most promising types of stem cells for translational application because of their rich tissue sources, multilineage differentiation capacity, and easy amplification in vitro and unique immunobiological properties. This study demonstrated that adipose-derived MSCs (AD-MSCs) infusion can significantly suppress the increase in body weight and remarkably improve dyslipidemia in obese mice. Induction of white fat tissue "browning" and activation of adenosine monophosphate-activated protein kinase and its downstream hormone-sensitive lipase in adipose tissue were demonstrated to contribute to the antiobesity and lipid-lowering effects. Thus, AD-MSC infusion holds great therapeutic potential for dyslipidemia.
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing, People's Republic of China.
authors.forename: Guang-Yang
authors.initials: GY
authors.lastname: Liu
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing, People's Republic of China.
authors.forename: Jin
authors.initials: J
authors.lastname: Liu
authors.affiliation: Beijing Institute of Biotechnology, Beijing, People's Republic of China.
authors.forename: You-Liang
authors.initials: YL
authors.lastname: Wang
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing, People's Republic of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Beijing Institute of Biotechnology, Beijing, People's Republic of China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Shao
authors.affiliation: Department of Plastic Surgery, Chinese PLA General Hospital, Beijing, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Han
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing, People's Republic of China.
authors.forename: Ya-Ru
authors.initials: YR
authors.lastname: Qin
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing, People's Republic of China.
authors.forename: Feng-Jun
authors.initials: FJ
authors.lastname: Xiao
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing, People's Republic of China.
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Li
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing, People's Republic of China.
authors.forename: Lan-Jun
authors.initials: LJ
authors.lastname: Zhao
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing, People's Republic of China.
authors.forename: En-Yan
authors.initials: EY
authors.lastname: Gu
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing, People's Republic of China.
authors.forename: Si-Yu
authors.initials: SY
authors.lastname: Chen
authors.affiliation: Beijing Institute of Biotechnology, Beijing, People's Republic of China.
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Gao
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing, People's Republic of China.
authors.forename: Chu-Tse
authors.initials: CT
authors.lastname: Wu
authors.affiliation: Beijing Institute of Biotechnology, Beijing, People's Republic of China huxw1969@163.com duanhf0720@163.com.
authors.forename: Xian-Wen
authors.initials: XW
authors.lastname: Hu
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing, People's Republic of China huxw1969@163.com duanhf0720@163.com.
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Duan
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism; D000273:Adipose Tissue / Q000166:cytology*; D000818:Animals; D001786:Blood Glucose; D015153:Blotting, Western; D004195:Disease Models, Animal; D050171:Dyslipidemias / Q000378:metabolism*; D007150:Immunohistochemistry; D008055:Lipids / Q000097:blood; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D060888:Real-Time Polymerase Chain Reaction; D002787:Sterol Esterase / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D008055:Lipids; D055372:AMP-Activated Protein Kinases; D002787:Sterol Esterase
keywords: Adenosine monophosphate-activated protein kinase; Adipose-derived mesenchymal stem cell; Anti-obesity; Lipid metabolism