title: Diazepam reduces excitability of amygdala and further influences auditory cortex following sodium salicylate treatment in rats.
abstract: CONCLUSIONS
  Diazepam can reduce the excitability of lateral amygdala and eventually suppress the excitability of the auditory cortex in rats following salicylate treatment, indicating the regulating effect of lateral amygdala to the auditory cortex in the tinnitus procedure.
  
  
  OBJECTIVE
  To study the spontaneous firing rates (SFR) of the auditory cortex and lateral amygdala regulated by diazepam in the tinnitus rat model induced by sodium salicylate.
  
  
  METHODS
  This study first created a tinnitus rat modal induced by sodium salicylate, and recorded SFR of both auditory cortex and lateral amygdala. Then diazepam was intraperitoneally injected and the SFR changes of lateral amygdala recorded. Finally, diazepam was microinjected on lateral amygdala and the SFR changes of the auditory cortex recorded.
  
  
  RESULTS
  Both SFRs of the auditory cortex and lateral amygdala increased after salicylate treatment. SFR of lateral amygdala decreased after intraperitoneal injection of diazepam. Microinjecting diazepam to lateral amygdala decreased SFR of the auditory cortex ipsilaterally and contralaterally.
authors.affiliation: a Department of Otorhinolaryngology , Peking University Third Hospital , Beijing , PR China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Song
authors.affiliation: a Department of Otorhinolaryngology , Peking University Third Hospital , Beijing , PR China.
authors.forename: Junxiu
authors.initials: J
authors.lastname: Liu
authors.affiliation: a Department of Otorhinolaryngology , Peking University Third Hospital , Beijing , PR China.
authors.forename: Furong
authors.initials: F
authors.lastname: Ma
authors.affiliation: b Beijing National Laboratory for Molecular Sciences; Key Laboratory of Analytical Chemistry for Living Biosystems , Institute of Chemistry, Chinese Academy of Sciences , Beijing , PR China.
authors.forename: Lanqun
authors.initials: L
authors.lastname: Mao
mesh_terms: D000679:Amygdala / Q000187:drug effects*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001303:Auditory Cortex / Q000187:drug effects*; D003975:Diazepam / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D008297:Male; D008845:Microinjections; D017208:Rats, Wistar; D012980:Sodium Salicylate; D014012:Tinnitus / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D014151:Anti-Anxiety Agents; D003975:Diazepam; D012980:Sodium Salicylate
keywords: Auditory cortex; diazepam; lateral amygdala; microinjection; single unit discharge; sodium salicylate