title: Palladium-catalyzed dearomatizing 2,5-alkoxyarylation of furan rings: diastereospecific access to spirooxindoles.
abstract: A protocol for Pd-catalyzed intra- and intermolecular 2,5-alkoxyarylation reactions of furans to diastereospecifically synthesize two series of spirooxindoles is reported. This protocol likely involves an intramolecular dearomatizing Heck-type α-arylation of the furan ring to produce a cyclic allylic palladium and the subsequent intra- or intermolecular introduction of an alkyloxyl group at the other α-position of the ring, with different facial selectivities.
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P. R. China. blyin@scut.edu.cn.
authors.forename: Jianchao
authors.initials: J
authors.lastname: Liu
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P. R. China. blyin@scut.edu.cn.
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Xu
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P. R. China. blyin@scut.edu.cn.
authors.forename: Jiuyi
authors.initials: J
authors.lastname: Li
authors.affiliation: Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou 510006, P. R. China. doctliu@263.net.
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P. R. China. blyin@scut.edu.cn.
authors.forename: Huanfeng
authors.initials: H
authors.lastname: Jiang
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P. R. China. blyin@scut.edu.cn.
authors.forename: Biaolin
authors.initials: B
authors.lastname: Yin