title: Bullous pemphigoid-like skin blistering disease in a rhesus macaque (Macaca mulatta).
abstract: Autoimmune bullous disease is very uncommon in non-human primates. We observed a bullous skin disease in a male rhesus monkey while conducting porcine islet xenotransplantation. Fifty days after the transplantation, multiple bullous skin lesions were observed. There was no mucosal involvement. Skin biopsy results demonstrated a subepidermal blister with no necrotic keratinocytes. Immunofluorescent staining showed linear IgG deposition at the roof of the blister. These skin lesions spontaneously disappeared. Considering these results, this monkey was diagnosed with bullous pemphigoid (BP). As far as we know, this is the first report of BP in non-human primates.
authors.affiliation: Xenotransplantation Research Center, Seoul National University Graduate School, Seoul, Korea.|Institute of Endemic Diseases, Seoul National University Graduate School, Seoul, Korea.
authors.forename: Jong-Min
authors.identifier: 0000-0003-0906-0117
authors.initials: JM
authors.lastname: Kim
authors.affiliation: Xenotransplantation Research Center, Seoul National University Graduate School, Seoul, Korea.|Department of Microbiology and Immunology, Seoul National University Graduate School, Seoul, Korea.|Cancer Research Institute, Seoul National University Graduate School, Seoul, Korea.|Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea.
authors.forename: Hyun-Je
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Xenotransplantation Research Center, Seoul National University Graduate School, Seoul, Korea.|Department of Microbiology and Immunology, Seoul National University Graduate School, Seoul, Korea.|Cancer Research Institute, Seoul National University Graduate School, Seoul, Korea.
authors.forename: Byoung-Hoon
authors.initials: BH
authors.lastname: Min
authors.affiliation: Xenotransplantation Research Center, Seoul National University Graduate School, Seoul, Korea.|Institute of Endemic Diseases, Seoul National University Graduate School, Seoul, Korea.|Department of Microbiology and Immunology, Seoul National University Graduate School, Seoul, Korea.|Cancer Research Institute, Seoul National University Graduate School, Seoul, Korea.|Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.
authors.forename: Jun-Seop
authors.initials: JS
authors.lastname: Shin
authors.affiliation: Xenotransplantation Research Center, Seoul National University Graduate School, Seoul, Korea.
authors.forename: Won Young
authors.initials: WY
authors.lastname: Jeong
authors.affiliation: Xenotransplantation Research Center, Seoul National University Graduate School, Seoul, Korea.
authors.forename: Ga Eul
authors.initials: GE
authors.lastname: Lee
authors.affiliation: Xenotransplantation Research Center, Seoul National University Graduate School, Seoul, Korea.
authors.forename: Min Sun
authors.initials: MS
authors.lastname: Kim
authors.affiliation: Xenotransplantation Research Center, Seoul National University Graduate School, Seoul, Korea.
authors.forename: Ju Eun
authors.initials: JE
authors.lastname: Kim
authors.affiliation: Xenotransplantation Research Center, Seoul National University Graduate School, Seoul, Korea.|Institute of Endemic Diseases, Seoul National University Graduate School, Seoul, Korea.|Department of Microbiology and Immunology, Seoul National University Graduate School, Seoul, Korea.|Cancer Research Institute, Seoul National University Graduate School, Seoul, Korea.|Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea.|Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.
authors.forename: Chung-Gyu
authors.initials: CG
authors.lastname: Park
mesh_terms: D000818:Animals; D008253:Macaca mulatta; D008297:Male; D008992:Monkey Diseases / Q000175:diagnosis* / Q000473:pathology; D010391:Pemphigoid, Bullous / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*
keywords: bullous pemphigoid; rhesus monkey; skin