title: TAS-102, the first "cardio-gentle" fluoropyrimidine in the colorectal cancer landscape?
abstract: Cardiotoxicity in the form of cardiac arrhythmia, myocardial infarction, and angina-like symptoms are not rare complications of fluoropyrimidines as 5-Fluorouracil (5FU) and capecitabine.
  
  
  
  Tas-102, a novel oral fluoropyrimidine, was recently approved by FDA for the treatment of advanced and refractory colorectal cancer. Its unique mechanism of action doesn't seem linked with cardiotoxicity in clinical trials reported so far. TAS 102 may represent one of the drugs of choice for patients with advanced colorectal cancer with cardiac disease. This intriguing and clinically relevant issue is briefly examined.
authors.affiliation: Department of Oncology, Division of Medical Oncology, Azienda Ospedaliera Treviglio, Piazzale Ospedale 1, 24047, Treviglio, BG, Italy.
authors.forename: Fausto
authors.initials: F
authors.lastname: Petrelli
authors.affiliation: Department of Oncology, Division of Medical Oncology, Azienda Ospedaliera Treviglio, Piazzale Ospedale 1, 24047, Treviglio, BG, Italy.
authors.forename: Sandro
authors.initials: S
authors.lastname: Barni
authors.affiliation: Oncology Department, Fondazione Poliambulanza, Via Bissolati 57, 25100, Brescia, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Bertocchi
authors.affiliation: Oncology Department, Fondazione Poliambulanza, Via Bissolati 57, 25100, Brescia, Italy. zanib@numerica.it.
authors.forename: Alberto
authors.initials: A
authors.lastname: Zaniboni
mesh_terms: D066126:Cardiotoxicity / Q000517:prevention & control*; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D004338:Drug Combinations; D006801:Humans; D011759:Pyrrolidines; D013941:Thymine; D016896:Treatment Outcome; D014271:Trifluridine / Q000008:administration & dosage* / Q000627:therapeutic use; D014498:Uracil / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D004338:Drug Combinations; D011759:Pyrrolidines; C000613803:trifluridine tipiracil drug combination; D014498:Uracil; D013941:Thymine; D014271:Trifluridine
keywords: Cardiotoxicity; Fluoropyrimidines; TAS-102