title: Genetic Variations in Phospholipase C-epsilon 1 (PLCE1) and Susceptibility to Colorectal Cancer Risk.
abstract: Colorectal cancer (CRC) is the third most common cause of cancer-related mortality and causes almost a million deaths worldwide each year. Genetic and environmental factors have gained importance in CRC as well as other types of cancer due to contribution to development of malignancies. Phosholipase C-epsilon 1 PLCE1 is one of the phospholipase family of enzymes and controls cellular responses leading to cell growth, differentiation and gene expression. Therefore, it was evaluated the effects of PLCE1 variations on developing CRC. Rs2274223 was significantly associated with CRC risk (OR = 2.018) while rs3765524 did not significantly differ (p > 0.05). The findings are the first results of PLCE1 profiles in the Turkish and could provide an understanding of aetiology in CRC.
authors.affiliation: Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Istanbul University, Beyazit, 34116, Istanbul, Turkey.
authors.forename: Oztas
authors.initials: O
authors.lastname: Ezgi
authors.affiliation: Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Istanbul University, Beyazit, 34116, Istanbul, Turkey.
authors.forename: Arici
authors.initials: A
authors.lastname: Merve
authors.affiliation: Department of General Surgery, Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Yanar Teoman
authors.initials: YT
authors.lastname: Hakan
authors.affiliation: Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Istanbul University, Beyazit, 34116, Istanbul, Turkey. gulozhan@istanbul.edu.tr.
authors.forename: Özhan
authors.initials: Ö
authors.lastname: Gül
mesh_terms: D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D054801:Phosphoinositide Phospholipase C / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D014421:Turkey
chemical_list: D054801:Phosphoinositide Phospholipase C; C423320:phospholipase C epsilon
keywords: Colorectal cancer; Genetic susceptibility; PLCE1