title: Molecular and Cellular Effects of Hydrogen Peroxide on Human Lung Cancer Cells: Potential Therapeutic Implications.
abstract: Lung cancer has a very high mortality-to-incidence ratio, representing one of the main causes of cancer mortality worldwide. Therefore, new treatment strategies are urgently needed. Several diseases including lung cancer have been associated with the action of reactive oxygen species (ROS) from which hydrogen peroxide (H2O2) is one of the most studied. Despite the fact that H2O2 may have opposite effects on cell proliferation depending on the concentration and cell type, it triggers several antiproliferative responses. H2O2 produces both nuclear and mitochondrial DNA lesions, increases the expression of cell adhesion molecules, and increases p53 activity and other transcription factors orchestrating cancer cell death. In addition, H2O2 facilitates the endocytosis of oligonucleotides, affects membrane proteins, induces calcium release, and decreases cancer cell migration and invasion. Furthermore, the MAPK pathway and the expression of genes related to inflammation including interleukins, TNF-α, and NF-κB are also affected by H2O2. Herein, we will summarize the main effects of hydrogen peroxide on human lung cancer leading to suggesting it as a potential therapeutic tool to fight this disease. Because of the multimechanistic nature of this molecule, novel therapeutic approaches for lung cancer based on the use of H2O2 may help to decrease the mortality from this malignancy.
authors.affiliation: Departamento de Ciencias de la Vida, Universidad de las Fuerzas Armadas (ESPE), Avenida General Rumiñahui, S/N, P.O. Box 171-5-231B, Sangolquí, Ecuador; Centro de Nanociencia y Nanotecnología, Universidad de las Fuerzas Armadas (ESPE), Avenida General Rumiñahui, S/N, P.O. Box 171-5-231B, Sangolquí, Ecuador; Department of Physiology, Anatomy and Genetics, University of Oxford, Le Gros Clark Building, South Parks Road, Oxford OX1 3QX, UK.
authors.forename: Gabriela
authors.identifier: 0000-0003-0110-5894
authors.initials: G
authors.lastname: Vilema-Enríquez
authors.affiliation: Department of Pharmacology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Avenida Instituto Politécnico Nacional 2508, 07360 Mexico City, DF, Mexico.
authors.forename: Aurora
authors.identifier: 0000-0001-8587-5241
authors.initials: A
authors.lastname: Arroyo
authors.affiliation: Departamento de Ciencias de la Vida, Universidad de las Fuerzas Armadas (ESPE), Avenida General Rumiñahui, S/N, P.O. Box 171-5-231B, Sangolquí, Ecuador; Centro de Nanociencia y Nanotecnología, Universidad de las Fuerzas Armadas (ESPE), Avenida General Rumiñahui, S/N, P.O. Box 171-5-231B, Sangolquí, Ecuador.
authors.forename: Marcelo
authors.identifier: 0000-0003-4970-7202
authors.initials: M
authors.lastname: Grijalva
authors.affiliation: Department of Genetics and Molecular Biology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Avenida Instituto Politécnico Nacional 2508, 07360 Mexico City, DF, Mexico.
authors.forename: Ricardo Israel
authors.identifier: 0000-0002-8414-0638
authors.initials: RI
authors.lastname: Amador-Zafra
authors.affiliation: Departamento de Ciencias de la Vida, Universidad de las Fuerzas Armadas (ESPE), Avenida General Rumiñahui, S/N, P.O. Box 171-5-231B, Sangolquí, Ecuador; Department of Pharmacology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Avenida Instituto Politécnico Nacional 2508, 07360 Mexico City, DF, Mexico.
authors.forename: Javier
authors.identifier: 0000-0002-8886-086X
authors.initials: J
authors.lastname: Camacho
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species; D006861:Hydrogen Peroxide