title: Gefitinib for asymptomatic brain metastasis from advanced non-small cell lung cancer: Report of a favourable outcome.
abstract: Brain metastasis (BM) is common in patients with non-small cell lung cancer (NSCLC). Although epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have now been included as standard treatment options for NSCLC harboring EGFR-activating mutations, only a few prospective reports demonstrate the efficacy of these agents in a BM setting. We report a case of a patient with advanced NSCLC, in which oral gefitinib documented a significant antitumor effect on parallel progression of extracranial lesion and BM occurred during chemotherapy.
authors.affiliation: Department of Radiation Oncology, Cancer Hospital and Institute Peking Union Medical College (PUMC) and Chinese Academy of Medical Sciences (CAMS) Beijing China.
authors.forename: Wen-Yang
authors.initials: WY
authors.lastname: Liu
authors.affiliation: Department of Medical Oncology, Cancer Hospital and Institute Peking Union Medical College (PUMC) and Chinese Academy of Medical Sciences (CAMS) Beijing China.
authors.forename: Yu-Tao
authors.initials: YT
authors.lastname: Liu
authors.affiliation: Department of Pathology, Cancer Hospital and Institute Peking Union Medical College (PUMC) and Chinese Academy of Medical Sciences (CAMS) Beijing China.
authors.forename: Lin
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Radiation Oncology, Cancer Hospital and Institute Peking Union Medical College (PUMC) and Chinese Academy of Medical Sciences (CAMS) Beijing China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Medical Oncology, Cancer Hospital and Institute Peking Union Medical College (PUMC) and Chinese Academy of Medical Sciences (CAMS) Beijing China.
authors.forename: Peng
authors.initials: P
authors.lastname: Liu
authors.affiliation: Department of Medical Oncology, Cancer Hospital and Institute Peking Union Medical College (PUMC) and Chinese Academy of Medical Sciences (CAMS) Beijing China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Radiation Oncology, Cancer Hospital and Institute Peking Union Medical College (PUMC) and Chinese Academy of Medical Sciences (CAMS) Beijing China.
authors.forename: Zhou-Guang
authors.initials: ZG
authors.lastname: Hui
keywords: Brain metastasis; gefitinib; non‐small‐cell lung cancer; radiotherapy; tyrosine kinase inhibitor