title: Redox Reducible and Hydrolytically Degradable PEG-PLA Elastomers as Biomaterial for Temporary Drug-Eluting Medical Devices.
abstract: With the aim to develop biomaterials for temporary medical devices, a series of novel reducible and/or degradable elastomers has been prepared from PLA-b-PEG-b-PLA copolymers photo-crosslinked with diallyl sulfide or pentaerythritol tetrakis(3-mercaptopropionate). Thermal and mechanical properties, including elastic limit and Young modulus, are assessed. Degradation is then evaluated under standard hydrolytic conditions. Reducibility of a selected elastomer is then illustrated using 2-mercaptoethanol or glutathione as reducing agents. The redox-sensitivity of the selected elastomer and the possibility to modulate the degradability are shown. Considering drug-eluting elastomeric devices applications, anti-inflammatory drug ibuprofen loading is illustrated with the two simplest elastomer formulations. A rapid or slow linear release is observed as a function of the low or high molecular weight of the triblock pre-polymers. Finally, the cytocompatibility of the degradable elastomers is assessed with regard to their potential to favor or inhibit L929 murine fibroblasts proliferation as a function of the hydrophilicity/hydrophobicity of the triblock copolymers.
authors.affiliation: Institute of Biomolecules Max Mousseron (IBMM) UMR 5247, Department of Artificial Biopolymers, CNRS, University of Montpellier, ENSCM. Faculté de Pharmacie 15 avenue Charles Flahault BP14491, 34093, Montpellier CEDEX 5, France.
authors.forename: Simona
authors.initials: S
authors.lastname: Rupnik
authors.affiliation: Institute of Biomolecules Max Mousseron (IBMM) UMR 5247, Department of Artificial Biopolymers, CNRS, University of Montpellier, ENSCM. Faculté de Pharmacie 15 avenue Charles Flahault BP14491, 34093, Montpellier CEDEX 5, France.
authors.forename: Sytze
authors.initials: S
authors.lastname: Buwalda
authors.affiliation: Institute of Biomolecules Max Mousseron (IBMM) UMR 5247, Department of Artificial Biopolymers, CNRS, University of Montpellier, ENSCM. Faculté de Pharmacie 15 avenue Charles Flahault BP14491, 34093, Montpellier CEDEX 5, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Dejean
authors.affiliation: Institute of Biomolecules Max Mousseron (IBMM) UMR 5247, Department of Artificial Biopolymers, CNRS, University of Montpellier, ENSCM. Faculté de Pharmacie 15 avenue Charles Flahault BP14491, 34093, Montpellier CEDEX 5, France.
authors.forename: Audrey
authors.initials: A
authors.lastname: Bethry
authors.affiliation: Institute of Biomolecules Max Mousseron (IBMM) UMR 5247, Department of Artificial Biopolymers, CNRS, University of Montpellier, ENSCM. Faculté de Pharmacie 15 avenue Charles Flahault BP14491, 34093, Montpellier CEDEX 5, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Garric
authors.affiliation: Institute of Biomolecules Max Mousseron (IBMM) UMR 5247, Department of Artificial Biopolymers, CNRS, University of Montpellier, ENSCM. Faculté de Pharmacie 15 avenue Charles Flahault BP14491, 34093, Montpellier CEDEX 5, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Coudane
authors.affiliation: Institute of Biomolecules Max Mousseron (IBMM) UMR 5247, Department of Artificial Biopolymers, CNRS, University of Montpellier, ENSCM. Faculté de Pharmacie 15 avenue Charles Flahault BP14491, 34093, Montpellier CEDEX 5, France.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Nottelet
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000378:metabolism; D001672:Biocompatible Materials / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects*; D002478:Cells, Cultured; D016503:Drug Delivery Systems / Q000295:instrumentation*; D065546:Drug Liberation; D020724:Elastomers / Q000737:chemistry*; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D006868:Hydrolysis; D007052:Ibuprofen / Q000378:metabolism*; D008422:Materials Testing; D051379:Mice; D010084:Oxidation-Reduction; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001672:Biocompatible Materials; D020724:Elastomers; D011108:Polymers; C542623:monomethoxypolyethyleneglycol-polylactide block copolymer; D011092:Polyethylene Glycols; D007052:Ibuprofen
keywords: degradation; drug release; elastomers; medical device; polyesters; redox