title: Reduction in Clostridium difficile infection associated with the introduction of hydrogen peroxide vapour automated room disinfection.
abstract: The clinical impact of implementing hydrogen peroxide vapour (HPV) disinfection of rooms vacated by patients with Clostridium difficile infection (CDI) was evaluated. Breakpoint time series analysis indicated a significant reduction (P<0.001) in the CDI rate at the time when HPV disinfection was implemented, resulting in a reduction in the CDI rate from 1.0 to 0.4 cases per 1000 patient-days in the 24 months before HPV usage compared with the first 24 months of HPV usage. HPV should be considered to augment the terminal disinfection of rooms vacated by patients with CDI.
authors.affiliation: North Mississippi Medical Center, Tupelo, MI, USA. Electronic address: jmccord@nmhs.net.
authors.forename: J
authors.initials: J
authors.lastname: McCord
authors.affiliation: North Mississippi Medical Center, Tupelo, MI, USA.
authors.forename: M
authors.initials: M
authors.lastname: Prewitt
authors.affiliation: Imperial College Healthcare NHS Trust, London, UK.
authors.forename: E
authors.initials: E
authors.lastname: Dyakova
authors.affiliation: Imperial College Healthcare NHS Trust, London, UK.
authors.forename: S
authors.initials: S
authors.lastname: Mookerjee
authors.affiliation: Imperial College Healthcare NHS Trust, London, UK.
authors.forename: J A
authors.initials: JA
authors.lastname: Otter
mesh_terms: D016360:Clostridioides difficile / Q000187:drug effects* / Q000302:isolation & purification; D003015:Clostridium Infections / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control*; D018562:Disease Transmission, Infectious / Q000517:prevention & control*; D004202:Disinfectants / Q000494:pharmacology*; D004203:Disinfection / Q000379:methods*; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D010362:Patients' Rooms; D014835:Volatilization
chemical_list: D004202:Disinfectants; D006861:Hydrogen Peroxide
keywords: CDI; Clostridium difficile; Decontamination; Disinfection; HPV; Hydrogen peroxide vapour