title: SHP2 and UGP2 are Biomarkers for Progression and Poor Prognosis of Gallbladder Cancer.
abstract: Biomarkers for the diagnosis, prognosis, and targeting therapy of gallbladder cancers are not clinically available. This study demonstrated that the percentage of cases with positive SHP2 and UGP2 expression significantly correlated with the percentage of cases with positive vimentin, β-catenin, MMP2, MMP9, and Ki-67 expression, large tumor size, high TNM stage, lymph node metastasis, and survival in patients with adenocarcinomas and squamous cell/adenosquamous carcinomas. Positive SHP2 and UGP2 expression are independent poor-prognostic factors in both types of tumors. Our study suggested that positive SHP2 and UGP2 expression correlated with clinicopathological and biological behaviors, and poor-prognosis of gallbladder cancer.
authors.affiliation: a Minimally Invasive Surgery Center , Central South University , Changsha , China.
authors.forename: Qunwei
authors.initials: Q
authors.lastname: Wang
authors.affiliation: b Research Laboratory of Hepatobiliary Diseases, Second Xiangya Hospital , Central South University , Changsha , China.
authors.forename: Zhu-Lin
authors.initials: ZL
authors.lastname: Yang
authors.affiliation: c Department of Pathology , Third Xiangya Hospital, Central South University , Changsha , China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Zou
authors.affiliation: c Department of Pathology , Third Xiangya Hospital, Central South University , Changsha , China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: d Department of Pathology , Xiangya Hospital, Central South University , Changsha , China.
authors.forename: Jinghe
authors.initials: J
authors.lastname: Li
authors.affiliation: e Department of Hepatobiliary and Pancreatic Surgery , Hunan Provincial People's Hospital , Changsha , China.
authors.forename: Lufeng
authors.initials: L
authors.lastname: Liang
authors.affiliation: f Department of Pathology , Loudi Central Hospital , Loudi , China.
authors.forename: Guixiang
authors.initials: G
authors.lastname: Zeng
authors.affiliation: g Department of Pathology , Hunan Provincial Tumor Hospital , Changsha , China.
authors.forename: Senlin
authors.initials: S
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor; D018450:Disease Progression; D005260:Female; D005706:Gallbladder Neoplasms / Q000175:diagnosis* / Q000378:metabolism* / Q000401:mortality / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11 / Q000378:metabolism*; D047368:Tumor Burden; D005957:UTP-Glucose-1-Phosphate Uridylyltransferase / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D005957:UTP-Glucose-1-Phosphate Uridylyltransferase; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11
keywords: Adenocarcinoma; Adenosquamous carcinoma; Gallbladder cancer; Metastasis; Prognosis; SHP2; Squamous cell carcinoma; UGP2