title: Who Regulates Whom? An Overview of RNA Granules and Viral Infections.
abstract: After viral infection, host cells respond by mounting an anti-viral stress response in order to create a hostile atmosphere for viral replication, leading to the shut-off of mRNA translation (protein synthesis) and the assembly of RNA granules. Two of these RNA granules have been well characterized in yeast and mammalian cells, stress granules (SGs), which are translationally silent sites of RNA triage and processing bodies (PBs), which are involved in mRNA degradation. This review discusses the role of these RNA granules in the evasion of anti-viral stress responses through virus-induced remodeling of cellular ribonucleoproteins (RNPs).
authors.affiliation: Molecular and Cellular Virology Laboratory, Virology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Independencia 1027, Santiago, 8389100, Chile. natalia.poblete.duran@gmail.com.
authors.forename: Natalia
authors.initials: N
authors.lastname: Poblete-Durán
authors.affiliation: Molecular and Cellular Virology Laboratory, Virology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Independencia 1027, Santiago, 8389100, Chile. ypradesp@ug.uchile.cl.
authors.forename: Yara
authors.initials: Y
authors.lastname: Prades-Pérez
authors.affiliation: Laboratorio de Virolog&#237;a Molecular, Instituto Milenio de Inmunolog&#237;a e Inmunoterapia, Centro de Investigaciones M&#233;dicas, Departamento de Enfermedades Infecciosas e Inmunolog&#237;a Pedi&#225;trica, Escuela de Medicina, Pontificia Universidad Cat&#243;lica de Chile, Marcoleta 391, Santiago 8330024, Chile. javochile@gmail.com.
authors.forename: Jorge
authors.initials: J
authors.lastname: Vera-Otarola
authors.affiliation: Molecular and Cellular Virology Laboratory, Virology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Independencia 1027, Santiago, 8389100, Chile. rsotorifo@med.uchile.cl.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Soto-Rifo
authors.affiliation: Molecular and Cellular Virology Laboratory, Virology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Independencia 1027, Santiago, 8389100, Chile. fvaliente@med.uchile.cl.
authors.forename: Fernando
authors.initials: F
authors.lastname: Valiente-Echeverría
mesh_terms: D003594:Cytoplasmic Granules / Q000378:metabolism*; D054884:Host-Pathogen Interactions; D014176:Protein Biosynthesis; D012367:RNA, Viral / Q000378:metabolism*; D013312:Stress, Physiological; D014780:Viruses / Q000254:growth & development* / Q000276:immunology*
chemical_list: D012367:RNA, Viral
keywords: P-bodies; RNA granules; anti-viral host immune response; stress granules; translation control