title: Chinese medicine for outcomes in colorectal cancer patients: A retrospective clinical study.
abstract: OBJECTIVE
  To investigate the effect of Chinese medicine (CM) on survival of patients with stage II and III colorectal cancer (CRC).
  
  
  METHODS
  A total of 295 patients who received chemotherapy were assigned to Group 1. The other 171 patients received the same chemotherapy treatment combined with the usage of CM Jianpi Jiedu Formula (, JPJD) for more than 3 months (Group 2). Patients' survival time, relapse and metastasis, and cause of death were observed. Cox proportional hazard regression models were established for the analysis of the effect of independent factors on the survival prognosis of patients with CRC.
  
  
  RESULTS
  The survival rate of patients in Group 2 was higher than that of Group 1 (P<0.05). Compared with Group 1, the mean survival time was prolonged by 5.594 months and the median survival time was prolonged by 6 months in Group 2 (P=0.004). Cox regression analysis indicated that CM combined with chemotherapy provided signifificant protective effect, as observed with the improvements in the survival rates of CRC patients (P<0.01).
  
  
  CONCLUSIONS
  CM can improve the survival rate in patients with stage II and III CRC.
authors.affiliation: Department of Integrated Traditional Chinese and Western Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410000, China.|Department of Cardiology, Baoan Hospital of Traditional Chinese Medicine, Shenzhen, Guangdong Province, 518000, China.
authors.forename: Feng-Xia
authors.initials: FX
authors.lastname: Lin
authors.affiliation: Department of Integrated Traditional Chinese and Western Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410000, China.|Zhangmuba Army Sanatoriums of Hunan Military Region, Changsha, Hunan, 410000, China.
authors.forename: Li-Feng
authors.initials: LF
authors.lastname: Tian
authors.affiliation: Department of Integrated Traditional Chinese and Western Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410000, China.
authors.forename: Cai-Yun
authors.initials: CY
authors.lastname: Lei
authors.affiliation: Department of Integrated Traditional Chinese and Western Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410000, China.
authors.forename: Chen-Chen
authors.initials: CC
authors.lastname: Ding
authors.affiliation: Department of Integrated Traditional Chinese and Western Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410000, China.
authors.forename: Li
authors.initials: L
authors.lastname: Shi
authors.affiliation: Department of Integrated Traditional Chinese and Western Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410000, China. zhangsifang2005@163.com.
authors.forename: Si-Fang
authors.initials: SF
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D004365:Drugs, Chinese Herbal
keywords: Chinese medicine; Jianpi Jiedu Formula; colorectal cancer; integrative medicine; survival period