title: Recipient and donor JAK2 46/1 haplotypes are associated with acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation.
abstract: Several genetic polymorphisms have been implicated to affect the outcome of allogeneic hematopoietic stem cell transplantation (allo-HSCT). The role of cytokines in acute graft-versus-host disease (aGvHD) is well established and many of the involved cytokines signal through the Janus kinase (JAK) pathways. In this study, we assessed the association of recipient and donor JAK2 46/1 haplotypes and allo-HSCT outcome in a cohort of 124 acute myeloid leukemia patients. Both, recipient and donor 46/1 haplotypes significantly affected aGvHD grades II-IV development (p = 0.006 and p = 0.031, respectively), furthermore the influence of the haplotypes seemed to be additive. In multivariate analyses the recipient haplotype remained independently related (p = 0.012) to aGvHD, while the donor not (p = 0.08). We observed significantly less relapses among haplotype carriers (p = 0.004), but overall survival did not differ (p = 0.732). Our findings suggest that recipient and donor JAK2 46/1 haplotypes might be involved in the regulation of aGvHD.
authors.affiliation: a School of PhD Studies , Semmelweis University , Budapest , Hungary.|b Laboratory of Molecular Diagnostics , Hungarian National Blood Transfusion Service , Budapest , Hungary.
authors.forename: Katalin
authors.initials: K
authors.lastname: Balassa
authors.affiliation: a School of PhD Studies , Semmelweis University , Budapest , Hungary.|b Laboratory of Molecular Diagnostics , Hungarian National Blood Transfusion Service , Budapest , Hungary.
authors.forename: Tunde
authors.initials: T
authors.lastname: Krahling
authors.affiliation: c Department of Hematology and Stem Cell Transplantation , St. Istvan and St. Laszlo Hospital , Budapest , Hungary.
authors.forename: Peter
authors.initials: P
authors.lastname: Remenyi
authors.affiliation: c Department of Hematology and Stem Cell Transplantation , St. Istvan and St. Laszlo Hospital , Budapest , Hungary.
authors.forename: Arpad
authors.initials: A
authors.lastname: Batai
authors.affiliation: b Laboratory of Molecular Diagnostics , Hungarian National Blood Transfusion Service , Budapest , Hungary.
authors.forename: Andras
authors.initials: A
authors.lastname: Bors
authors.affiliation: b Laboratory of Molecular Diagnostics , Hungarian National Blood Transfusion Service , Budapest , Hungary.
authors.forename: Katalin Piroska
authors.initials: KP
authors.lastname: Kiss
authors.affiliation: c Department of Hematology and Stem Cell Transplantation , St. Istvan and St. Laszlo Hospital , Budapest , Hungary.
authors.forename: Eva
authors.initials: E
authors.lastname: Torbagyi
authors.affiliation: c Department of Hematology and Stem Cell Transplantation , St. Istvan and St. Laszlo Hospital , Budapest , Hungary.
authors.forename: Laszlo
authors.initials: L
authors.lastname: Gopcsa
authors.affiliation: c Department of Hematology and Stem Cell Transplantation , St. Istvan and St. Laszlo Hospital , Budapest , Hungary.
authors.forename: Lilla
authors.initials: L
authors.lastname: Lengyel
authors.affiliation: c Department of Hematology and Stem Cell Transplantation , St. Istvan and St. Laszlo Hospital , Budapest , Hungary.
authors.forename: Aniko
authors.initials: A
authors.lastname: Barta
authors.affiliation: d 3rd Department of Internal Medicine , Semmelweis University , Budapest , Hungary.
authors.forename: Gergely
authors.initials: G
authors.lastname: Varga
authors.affiliation: b Laboratory of Molecular Diagnostics , Hungarian National Blood Transfusion Service , Budapest , Hungary.|e Department of Pathophysiology , Semmelweis University , Budapest , Hungary.
authors.forename: Attila
authors.initials: A
authors.lastname: Tordai
authors.affiliation: c Department of Hematology and Stem Cell Transplantation , St. Istvan and St. Laszlo Hospital , Budapest , Hungary.|d 3rd Department of Internal Medicine , Semmelweis University , Budapest , Hungary.
authors.forename: Tamas
authors.initials: T
authors.lastname: Masszi
authors.affiliation: b Laboratory of Molecular Diagnostics , Hungarian National Blood Transfusion Service , Budapest , Hungary.
authors.forename: Hajnalka
authors.initials: H
authors.lastname: Andrikovics
mesh_terms: D000328:Adult; D000483:Alleles; D015415:Biomarkers; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006086:Graft vs Host Disease / Q000209:etiology*; D006239:Haplotypes; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D053614:Janus Kinase 2 / Q000235:genetics*; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000235:genetics / Q000401:mortality / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009026:Mortality; D011110:Polymorphism, Genetic; D011379:Prognosis; D012008:Recurrence; D014019:Tissue Donors; D066027:Transplant Recipients; D014184:Transplantation, Homologous; D055815:Young Adult
chemical_list: D015415:Biomarkers; C507924:JAK2 protein, human; D053614:Janus Kinase 2
keywords: Acute graft-versus-host disease; JAK2 46/1 haplotype; acute myeloid leukemia; allogeneic hematopoietic stem cell transplantation