title: Sesquiterpenoids from the Rhizomes of Curcuma phaeocaulis and Their Inhibitory Effects on LPS-Induced TLR4 Activation.
abstract: Two new guaiane-type (2, 6) and one new furanogermacrane-type (11) sesquiterpenoids have been isolated along with twelve known compounds from an EtOAc-soluble extract of Curcuma phaeocaulis rhizomes. The structures of the isolated compounds were elucidated using a combination of NMR, MS, and circular dichroism (CD) spectra. The inhibitory effects of each compound on lipopolysaccharide (LPS)-induced Toll-like receptor 4 (TLR4) activation in THP-1-Blue cells were assessed, and compound 4 showed more potent inhibitory activity against LPS-stimulated TLR4 activation.
authors.affiliation: Natural Product Research Center, Korea Research Institute of Bioscience and Biotechnology.
authors.forename: Hyun-Jae
authors.initials: HJ
authors.lastname: Jang
authors.forename: Jin-Han
authors.initials: JH
authors.lastname: Kim
authors.forename: Hyun-Mee
authors.initials: HM
authors.lastname: Oh
authors.forename: Min-Suk
authors.initials: MS
authors.lastname: Kim
authors.forename: Jin Ha
authors.initials: JH
authors.lastname: Jo
authors.forename: Kyungsook
authors.initials: K
authors.lastname: Jung
authors.forename: Soyoung
authors.initials: S
authors.lastname: Lee
authors.forename: Young-Ho
authors.initials: YH
authors.lastname: Kim
authors.forename: Woo Song
authors.initials: WS
authors.lastname: Lee
authors.forename: Seung Woong
authors.initials: SW
authors.lastname: Lee
authors.forename: Mun-Chual
authors.initials: MC
authors.lastname: Rho
mesh_terms: D030024:Curcuma / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D008968:Molecular Conformation; D027343:Rhizome / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D051197:Toll-Like Receptor 4 / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D008070:Lipopolysaccharides; D012717:Sesquiterpenes; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4