title: Treatment of Bowen Disease With Photodynamic Therapy and the Advantages of Sequential Topical Imiquimod.
abstract: Photodynamic therapy (PDT) has been shown to be useful and effective in the treatment of actinic keratosis, Bowen disease, and basal cell carcinoma. We present a series of 13 Bowen disease lesions treated using PDT. Complete responses were achieved in 11 (84%) of the lesions after 3 months of treatment; at 18 months, complete responses were seen in 9 (70%) of the lesions. Patients who presented a partial response or recurrence were treated with topical 5% imiquimod and achieved complete responses. The lesions that presented partial response or recurrence were the largest lesions, between 3 and 5cm in diameter. PDT in monotherapy or combined sequentially with imiquimod is an excellent and well-tolerated therapeutic option for Bowen disease. The treatment has few adverse effects and shows satisfactory results, particularly in multiple large lesions in areas of difficult surgical reconstruction or in elderly patients with a high surgical risk.
authors.affiliation: Servicio de Dermatología, Hospital General Universitario de Valencia, Valencia, España. Electronic address: anamercevictoria@gmail.com.
authors.forename: A M
authors.initials: AM
authors.lastname: Victoria-Martínez
authors.affiliation: Servicio de Dermatología, Hospital General Universitario de Valencia, Valencia, España.
authors.forename: L
authors.initials: L
authors.lastname: Martínez-Leborans
authors.affiliation: Servicio de Dermatología, Hospital General Universitario de Valencia, Valencia, España.
authors.forename: J M
authors.initials: JM
authors.lastname: Ortiz-Salvador
authors.affiliation: Servicio de Dermatología, Hospital General Universitario de Valencia, Valencia, España.
authors.forename: A
authors.initials: A
authors.lastname: Pérez-Ferriols
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000634:Aminoquinolines / Q000008:administration & dosage / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001913:Bowen's Disease / Q000188:drug therapy*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D000077271:Imiquimod; D008297:Male; D010778:Photochemotherapy; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000634:Aminoquinolines; D000970:Antineoplastic Agents; D000077271:Imiquimod
keywords: Bowen disease; Enfermedad de Bowen; Imiquimod tópico; Photodynamic therapy; Terapia fotodinámica; Topical imiquimod; Tratamiento; Treatment