title: Switchable Liposomes: Targeting-Peptide-Functionalized and pH-Triggered Cytoplasmic Delivery.
abstract: One switchable nanodelivery system was constructed. Liposomes were functionalized by a novel dual-recognition peptide STP, which is pH-responsive as well as the affinity ligand of tumor marker VEGFR2 (the angiogenesis marker vascular endothelial growth factor receptor 2). Efficient drug delivery and in vivo therapy could be "turned on" and accelerated only in the conditions of VEGFR2 overexpression and a mild acidic environment. We envisioned that the successful demonstration of this switchable nanocarrier system would open a new avenue on rapid cytoplasmic delivery for specific cancer diagnostics and therapeutics.
authors.affiliation: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology , Beijing 100190, China.
authors.forename: Qiuju
authors.initials: Q
authors.lastname: Han
authors.affiliation: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology , Beijing 100190, China.
authors.forename: Weizhi
authors.initials: W
authors.lastname: Wang
authors.affiliation: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology , Beijing 100190, China.
authors.forename: Xiangqian
authors.initials: X
authors.lastname: Jia
authors.affiliation: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology , Beijing 100190, China.
authors.forename: Yixia
authors.initials: Y
authors.lastname: Qian
authors.affiliation: Institute of Chemistry, Chinese Academy of Science , Beijing 100190, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Li
authors.affiliation: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology , Beijing 100190, China.
authors.forename: Zihua
authors.initials: Z
authors.lastname: Wang
authors.affiliation: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology , Beijing 100190, China.|Medical College, Henan University of Science and Technology , Luoyang, Henan 471003, China.
authors.forename: Weikai
authors.initials: W
authors.lastname: Zhang
authors.affiliation: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology , Beijing 100190, China.
authors.forename: Shu
authors.initials: S
authors.lastname: Yang
authors.forename: Yunhong
authors.initials: Y
authors.lastname: Jia
authors.affiliation: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology , Beijing 100190, China.
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Hu
mesh_terms: D045744:Cell Line, Tumor; D016503:Drug Delivery Systems; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008081:Liposomes / Q000737:chemistry*; D010455:Peptides; D042461:Vascular Endothelial Growth Factor A
chemical_list: D008081:Liposomes; D010455:Peptides; D042461:Vascular Endothelial Growth Factor A
keywords: VEGFR2; cancer therapy; drug delivery; pH-responsive peptide; switchable liposomes