title: Mechanotransduction pulls the strings of matrix degradation at invadosome.
abstract: Degradation of the extracellular matrix is a critical step of tumor cell invasion. Both protease-dependent and -independent mechanisms have been described as alternate processes in cancer cell motility. Interestingly, some effectors of protease-dependent degradation are focalized at invadosomes and are directly coupled with contractile and adhesive machineries composed of multiple mechanosensitive proteins. This review presents recent findings in protease-dependent mechanisms elucidating the ways the force affects extracellular matrix degradation by targeting protease expression and activity at invadosome. The aim is to highlight mechanosensing and mechanotransduction processes to direct the degradative activity at invadosomes, with the focus on membrane tension, proteases and mechanosensitive ion channels.
authors.affiliation: INSERM U1209, Grenoble F-38042, France; Université Grenoble Alpes, Institut Albert Bonniot, F-38042 Grenoble, France; CNRS UMR 5309, F-38042 Grenoble, France.
authors.forename: Sanela
authors.initials: S
authors.lastname: Mrkonjic
authors.affiliation: INSERM U1209, Grenoble F-38042, France; Université Grenoble Alpes, Institut Albert Bonniot, F-38042 Grenoble, France; CNRS UMR 5309, F-38042 Grenoble, France. Electronic address: Olivier.destaing@univ-grenoble-alpes.fr.
authors.forename: Olivier
authors.initials: O
authors.lastname: Destaing
authors.affiliation: INSERM U1209, Grenoble F-38042, France; Université Grenoble Alpes, Institut Albert Bonniot, F-38042 Grenoble, France; CNRS UMR 5309, F-38042 Grenoble, France. Electronic address: Corinne.albiges-rizo@univ-grenoble-alpes.fr.
authors.forename: Corinne
authors.initials: C
authors.lastname: Albiges-Rizo
mesh_terms: D001696:Biomechanical Phenomena; D015220:Calcium Channels / Q000235:genetics / Q000378:metabolism; D002448:Cell Adhesion; D002462:Cell Membrane / Q000378:metabolism / Q000473:pathology; D002465:Cell Movement; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000235:genetics / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism* / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D020782:Matrix Metalloproteinases / Q000235:genetics / Q000378:metabolism*; D040542:Mechanotransduction, Cellular; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D000069261:Podosomes / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D015222:Sodium Channels / Q000235:genetics / Q000378:metabolism; D013500:Surface Tension
chemical_list: D015220:Calcium Channels; D009363:Neoplasm Proteins; D015222:Sodium Channels; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; D020782:Matrix Metalloproteinases