title: C-type natriuretic peptide is closely associated to obesity in Caucasian adolescents.
abstract: CNP is a natural regulator of adipogenesis playing a role in the development of obesity in childhood. Aim of the study was to evaluate CNP plasma levels in normal-weight (N), overweight (OW) and obese adolescents (O). Eighty two subjects (age:12.8±2.4, years) without cardiac dysfunction were enrolled and CNP plasma levels were measured by RIA. NT-proBNP, MR-proANP, AGEs, reactive hyperemia index (RHI) and standard clinical chemistry parameters were also measured. O and OW adolescents had higher values of BMI and fat mass than N. CNP levels were significantly lower in OW:4.79[3.29-21.15] and O:3.81[1.55-13.4] than in N:13.21[7.6-37.8]; p<0.0001N vs O, p=0.0003N vs OW). LogCNP values correlated significantly and inversely with BMI z-score, FM%, TF% and circulating levels of CRP, insulin, total cholesterol, LDL, and triglycerides, in addition to an inverse relationship with skin AGEs and a direct correlation with RHI. LogCNP was also inversely associated with LogNT-proBNP and LogMR-proANP values. Using ROC analysis the risk of obesity resulted significantly (p≪0.0001) associated with CNP values (AUC=0.9724). These results suggest that CNP may play a more important role than BNP and ANP related peptides, as risk marker of obesity, in addition to its involvement in adipogenesis and endothelial dysfunction.
authors.affiliation: Laboratory of Biochemistry and Molecular Biology, Institute of Clinical Physiology, CNR, Pisa, Italy. Electronic address: delry@ifc.cnr.it.
authors.forename: Silvia
authors.initials: S
authors.lastname: Del Ry
authors.affiliation: Laboratory of Biochemistry and Molecular Biology, Institute of Clinical Physiology, CNR, Pisa, Italy.
authors.forename: Manuela
authors.initials: M
authors.lastname: Cabiati
authors.affiliation: Unit of Pediatric Endocrinology and Diabetes, Dep. Clinical and Experimental Medicine, University of Pisa, Italy.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Bianchi
authors.affiliation: Translational Research Department, University of Pisa, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Caponi
authors.affiliation: Fondazione Toscana G. Monasterio, Pisa, Italy.
authors.forename: Maristella
authors.initials: M
authors.lastname: Maltinti
authors.affiliation: Laboratory of Biochemistry and Molecular Biology, Institute of Clinical Physiology, CNR, Pisa, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Caselli
authors.affiliation: Department of Clinical and Experimental Medicine, University of Pisa, Italy.
authors.forename: Michaela
authors.initials: M
authors.lastname: Kozakova
authors.affiliation: Department of Surgical, Medical, Molecular Pathology and Critical Care Medicine, University of Pisa, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Palombo
authors.affiliation: Department of Surgical, Medical, Molecular Pathology and Critical Care Medicine, University of Pisa, Italy.
authors.forename: Carmela
authors.initials: C
authors.lastname: Morizzo
authors.affiliation: Unit of Pediatric Endocrinology and Diabetes, Dep. Clinical and Experimental Medicine, University of Pisa, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Marchetti
authors.affiliation: Unit of Pediatric Endocrinology and Diabetes, Dep. Clinical and Experimental Medicine, University of Pisa, Italy.
authors.forename: Emioli
authors.initials: E
authors.lastname: Randazzo
authors.affiliation: Fondazione Toscana G. Monasterio, Pisa, Italy.
authors.forename: Aldo
authors.initials: A
authors.lastname: Clerico
authors.affiliation: Unit of Pediatric Endocrinology and Diabetes, Dep. Clinical and Experimental Medicine, University of Pisa, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Federico
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002648:Child; D015331:Cohort Studies; D006801:Humans; D020098:Natriuretic Peptide, C-Type / Q000097:blood*; D045265:Natriuretic Peptides / Q000097:blood; D009765:Obesity / Q000097:blood*; D050177:Overweight; D012372:ROC Curve; D011863:Radioimmunoassay; D012307:Risk Factors; D044465:White People
chemical_list: D015415:Biomarkers; D045265:Natriuretic Peptides; D020098:Natriuretic Peptide, C-Type
keywords: AGEs; Adolescents; C-type natriuretic peptide; Growth; Natriuretic peptides; Obesity