title: Molecular Mechanism of Adult Neurogenesis and its Association with Human Brain Diseases.
abstract: Recent advances in neuroscience challenge the old dogma that neurogenesis occurs only during embryonic development. Mounting evidence suggests that functional neurogenesis occurs throughout adulthood. This review article discusses molecular factors that affect adult neurogenesis, including morphogens, growth factors, neurotransmitters, transcription factors, and epigenetic factors. Furthermore, we summarize and compare current evidence of associations between adult neurogenesis and human brain diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and brain tumors.
authors.affiliation: Department of Biology, Morosky College of Health Professions and Sciences, Gannon University, Erie, PA, USA.
authors.forename: He
authors.initials: H
authors.lastname: Liu
authors.affiliation: Division of Health Sciences & Workforce Technology, Lamar State College-Orange, Orange, TX, USA.
authors.forename: Ni
authors.initials: N
authors.lastname: Song
keywords: adult neurogenesis; human brain diseases; molecular factors