title: Disturbance of zinc and glucose homeostasis by methyl tert-butyl ether (MTBE); evidence for type 2 diabetes.
abstract: 1. The prevalence of diabetes and the other metabolic disorders has noticeably increased worldwide. A causal link between increasing risk of type 2 diabetes and exposure to environmental pollutants has been reported. 2. We hypothesized that exposure to methyl tert-butyl ether (MTBE), an oxygenate additive to gasoline would hinder zinc and glucose homeostasis in rats. 3. Male Sprague-Dawley rats received MTBE in drinking water for 90 days. At the end of the treatment, pancreas and blood samples were collected for biochemical and molecular examinations. Expression of four candidate genes, including Insulin1, Insulin2, MT1A, SLC30A8 by Real-Time Quantitative PCR (Q-PCR) as well as biochemical parameters, including fasting blood glucose (FBS), triglycerides (TG), cholesterol (CHO), low-density lipoprotein (LDL), high-density lipoprotein (HDL), copper (Cu2+) and calcium (Ca2+) levels as well as High-sensitive C-reactive protein were assessed as endpoints. 4. This study suggested that MTBE exposure can be associated with disruption in zinc homeostasis and glucose tolerance.
authors.affiliation: a Department of Pharmacology and Toxicology , School of Pharmacy, Shiraz University of Medical Sciences , Shiraz , Iran and.
authors.forename: Arastoo
authors.initials: A
authors.lastname: Saeedi
authors.affiliation: b Department of Radiology , School of Paramedical Sciences, Shiraz University of Medical Sciences , Shiraz , Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Fardid
authors.affiliation: a Department of Pharmacology and Toxicology , School of Pharmacy, Shiraz University of Medical Sciences , Shiraz , Iran and.
authors.forename: Mohammad Javad
authors.initials: MJ
authors.lastname: Khoshnoud
authors.affiliation: b Department of Radiology , School of Paramedical Sciences, Shiraz University of Medical Sciences , Shiraz , Iran.
authors.forename: Elaheh
authors.initials: E
authors.lastname: Kazemi
authors.affiliation: a Department of Pharmacology and Toxicology , School of Pharmacy, Shiraz University of Medical Sciences , Shiraz , Iran and.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Omidi
authors.affiliation: a Department of Pharmacology and Toxicology , School of Pharmacy, Shiraz University of Medical Sciences , Shiraz , Iran and.
authors.forename: Afshin
authors.initials: A
authors.lastname: Mohammadi-Bardbori
mesh_terms: D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000139:chemically induced*; D005947:Glucose / Q000378:metabolism; D006706:Homeostasis / Q000187:drug effects*; D008297:Male; D008738:Methyl Ethers / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015032:Zinc / Q000378:metabolism
chemical_list: D000393:Air Pollutants; D008738:Methyl Ethers; C043243:methyl tert-butyl ether; D005947:Glucose; D015032:Zinc
keywords: Gene expression; MT1A; ZnT-8; glucose homeostasis; insulin; methyl tert-butyl ether (MTBE); type 2 diabetes; zinc homeostasis