title: Pulmonary Hypertension and Indicators of Right Ventricular Function.
abstract: Pulmonary hypertension (PH) is a rare disease, whose underlying mechanisms are not fully understood. It is characterized by pulmonary arterial vasoconstriction and vessels wall thickening, mainly intimal and medial layers. Several molecular pathways have been studied, but their respective roles remain unknown. Cardiac repercussions of PH are hypertrophy, dilation, and progressive right ventricular dysfunction. Multiple echocardiographic parameters are being used, in order to assess anatomy and cardiac function, but there are no guidelines edited about their usefulness. Thus, it is now recommended to associate the best-known parameters, such as atrial and ventricular diameters or tricuspid annular plane systolic excursion. Cardiac catheterization remains necessary to establish the diagnosis of PH and to assess pulmonary hemodynamic state. Concerning energetic metabolism, free fatty acids, normally used to provide energy for myocardial contraction, are replaced by glucose uptake. These abnormalities are illustrated by increased (18)F-fluorodeoxyglucose ((18)F-FDG) uptake on positron emission tomography/computed tomography, which seems to be correlated with echocardiographic and hemodynamic parameters.
authors.affiliation: University of Lausanne , Lausanne , Switzerland.
authors.forename: Célia
authors.initials: C
authors.lastname: von Siebenthal
authors.affiliation: Pneumology, Centre Hospitalier Universitaire Vaudois , Lausanne , Switzerland.
authors.forename: John-David
authors.initials: JD
authors.lastname: Aubert
authors.affiliation: Nuclear Medicine and Molecular Imaging, Centre Hospitalier Universitaire Vaudois , Lausanne , Switzerland.
authors.forename: Periklis
authors.initials: P
authors.lastname: Mitsakis
authors.affiliation: Cardiology, Centre Hospitalier Universitaire Vaudois , Lausanne , Switzerland.
authors.forename: Patrick
authors.initials: P
authors.lastname: Yerly
authors.affiliation: Nuclear Medicine and Molecular Imaging, Centre Hospitalier Universitaire Vaudois , Lausanne , Switzerland.
authors.forename: John O
authors.initials: JO
authors.lastname: Prior
authors.affiliation: Pneumology, Centre Hospitalier Universitaire Vaudois , Lausanne , Switzerland.
authors.forename: Laurent Pierre
authors.initials: LP
authors.lastname: Nicod
keywords: PET/CT; cardiac catheterization; echocardiography; pulmonary hypertension; right ventricle