title: Association Between Body Mass Index and Diabetes in Northeastern China: Based on Dose-Response Analyses Using Restricted Cubic Spline Functions.
abstract: A high body mass index (BMI) is a major risk factor for diabetes, although little is known about the characterization of a dose-response association adjusted for potential confounders. This cross-sectional study was conducted from June 2012 to August 2012; a total of 21 435 inhabitants in Jilin Province aged between 18 and 79 years were selected randomly based on multistage, stratified cluster sampling. The estimated prevalence of diabetes was 9.1% overall, 9.4% in males and 8.9% in females. After adjusting for potential confounders, the multivariable-adjusted odds ratios for the BMI-diabetes association were 1.337 (95% confidence interval = 1.185-1.508) and 1.696 (95% confidence interval = 1.429-2.042), respectively, for overweight and obesity. Through multivariable restricted cubic spline regression, continuous variation in BMI was found to be related to diabetes in a nonlinear manner (P < .001) after adjustment for confounders in both different gender and different age groups, suggesting that there is an adjusted dose-response association between continuous BMI and diabetes, with substantial population-level effects.
authors.affiliation: Jilin University, Changchun, Jilin Province, China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Su
authors.affiliation: Jilin University, Changchun, Jilin Province, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Jilin University, Changchun, Jilin Province, China.
authors.forename: Wenwang
authors.initials: W
authors.lastname: Rao
authors.affiliation: Jilin University, Changchun, Jilin Province, China.
authors.forename: Guang
authors.initials: G
authors.lastname: Yang
authors.affiliation: Jilin University, Changchun, Jilin Province, China.
authors.forename: Shibin
authors.initials: S
authors.lastname: Wang
authors.affiliation: Jilin University, Changchun, Jilin Province, China.
authors.forename: Yingli
authors.initials: Y
authors.lastname: Fu
authors.affiliation: Jilin University, Changchun, Jilin Province, China.
authors.forename: Yingyu
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Jilin University, Changchun, Jilin Province, China.
authors.forename: Yangyu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Jilin University, Changchun, Jilin Province, China.
authors.forename: Yueyue
authors.initials: Y
authors.lastname: You
authors.affiliation: Jilin University, Changchun, Jilin Province, China.
authors.forename: Yaqin
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Jilin University, Changchun, Jilin Province, China koucg@jlu.edu.cn.
authors.forename: Changgui
authors.initials: C
authors.lastname: Kou
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology; D050177:Overweight / Q000453:epidemiology*; D015995:Prevalence; D012307:Risk Factors; D055815:Young Adult
keywords: Northeastern China; body mass index; cross-sectional study; diabetes; restricted cubic spline