title: The prebiotic concept and human health: a changing landscape with riboflavin as a novel prebiotic candidate?
abstract: Emerging evidence suggests that the gut microbiota has a critical role in both the maintenance of human health and the pathogenesis of many diseases. Modifying the colonic microbiota using functional foods has attracted significant research effort and product development. The pioneering concept of prebiotics, as introduced by Gibson and Roberfroid in the 1990s, emphasized the importance of diet in the modulation of the gut microbiota and its relationships to human health. Increasing knowledge of the intestinal microbiota now suggests a more comprehensive definition. This paper briefly reviews the basics of the prebiotic concept with a discussion of recent attempts to refine the concept to open the door for novel prebiotic food ingredients, such as polyphenols, minerals and vitamins.
authors.affiliation: R&D Human Nutrition and Health, DSM Nutritional Products Ltd, Basel, Switzerland.
authors.forename: R E
authors.initials: RE
authors.lastname: Steinert
authors.affiliation: Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Sadaghian Sadabad
authors.affiliation: Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
authors.forename: H J M
authors.initials: HJ
authors.lastname: Harmsen
authors.affiliation: R&D Human Nutrition and Health, DSM Nutritional Products Ltd, Basel, Switzerland.
authors.forename: P
authors.initials: P
authors.lastname: Weber
mesh_terms: D055951:Functional Food / Q000382:microbiology; D000069196:Gastrointestinal Microbiome; D006801:Humans; D056692:Prebiotics; D012256:Riboflavin / Q000627:therapeutic use*; D014803:Vitamin B Complex / Q000627:therapeutic use*
chemical_list: D056692:Prebiotics; D014803:Vitamin B Complex; D012256:Riboflavin