title: Perioperative Anaesthetic Approach in a Homozygous Sickle Cell Anaemia Patient with Frequent Pain Crises.
abstract: Sickle cell disease (HbS) is a haemolytic anaemia characterized by the formation of abnormal haemoglobin. In patients with sickle cell disease, high rates of erythrocyte generation, degradation, and hyperbilirubinemia increase the risk for cholelithiasis. Previous studies have found that the incidence of cholelithiasis is 70% in adult patients. In sickle cell disease, decreased oxygen concentration leads to the sickling of erythrocytes by causing aggregation and polymerization. Sickle erythrocytes can have devastating effects on many vital organs by causing microvascular occlusion. In patients with sickle cell anaemia, anaesthetic technique, anaesthetic agents, and surgical trauma may cause additional risk. In this case report, we present a perioperative anaesthetic approach in the laparoscopic cholecystectomy of a patient with HbS, elevated liver function tests, and frequent pain crises.
authors.affiliation: Department of Anaesthesiology and Reanimation, Mustafa Kemal University Faculty of Medicine, Hatay, Turkey.
authors.forename: Kasım
authors.initials: K
authors.lastname: Tuzcu
authors.affiliation: Department of Anaesthesiology and Reanimation, Mustafa Kemal University Faculty of Medicine, Hatay, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Karcıoğlu
authors.affiliation: Department of Anaesthesiology and Reanimation, Mustafa Kemal University Faculty of Medicine, Hatay, Turkey.
authors.forename: Işıl
authors.initials: I
authors.lastname: Davarcı
authors.affiliation: Department of Anaesthesiology and Reanimation, Mustafa Kemal University Faculty of Medicine, Hatay, Turkey.
authors.forename: Sedat
authors.initials: S
authors.lastname: Hakimoğlu
authors.affiliation: Department of General Surgery, Mustafa Kemal University Faculty of Medicine, Hatay, Turkey.
authors.forename: Seçkin
authors.initials: S
authors.lastname: Akküçük
keywords: Sickle cell anemia; anaesthesia; laparoscopic cholecystectomy