title: Time perception of simultaneous and sequential events in early-onset schizophrenia.
abstract: Timing disorders in schizophrenia are a well-known phenomenon. However, no studies have yet assessed the role of temporal distortions in early-onset schizophrenia (EOS), despite evidence that distorted time perception may share genetic risk factors with schizophrenia and may be a useful indicator in identifying individuals at risk for schizophrenia. In the present study, we investigated the ability of 10 patients with EOS (mean age = 21.5 years, SD = 6) matched with 20 healthy control participants (mean age = 25.3 years, SD = 4.6) in order to compare the durations of two visual events, presented either sequentially or overlapping in time, along with neuropsychological assessments of attention, working memory, and executive functions. Each participant had to judge a total of 336 stimuli. We found that temporal overlap had a greater negative effect on ability to judge the duration of a pair of stimuli in EOS patients than in healthy control participants. In addition, EOS patients showed impairments in attention and executive functions. Furthermore, in EOS patients, the scores for executive and attentional functions were significantly correlated with accuracy of temporal estimation in the overlap condition (r = 0.31, p < 0.05 and r = 0.57, p < 0.05, respectively). These preliminary results suggest that impairments in neuropsychological functions participate in the deficit in time estimation observed in patients with EOS. These conclusions highlight the importance of testing time perception in patients with EOS and could contribute to the development of cognitive remediation-based therapy for these patients.
authors.affiliation: a Laboratoire Cognitions Humaine et Artificielle (CHArt-UPO, EA 4004) & Université Paris Ouest Nanterre la Défense , Nanterre, France.
authors.forename: M
authors.initials: M
authors.lastname: de Montalembert
authors.affiliation: b Laboratoire Psychologie de la Perception (CNRS UMR 8242) , Université Paris Descartes , Paris, France.|c Département de Psychiatrie , Université de Brest, CHU de Brest , Brest, France.
authors.forename: N
authors.initials: N
authors.lastname: Coulon
authors.affiliation: d Service de Psychiatrie de l'enfant et de l'adolescent, CNRS UMR 7222 Institut des Systèmes Intelligents et Robotiques, GH Pitié Salpêtrière, AP-HP, UPMC , Paris , France.
authors.forename: D
authors.initials: D
authors.lastname: Cohen
authors.affiliation: e Unité Universitaire de Psychiatrie de l'Enfant et de l'Adolescent , Hôpital Mère-Enfant, CHU de Nantes , France.
authors.forename: O
authors.initials: O
authors.lastname: Bonnot
authors.affiliation: b Laboratoire Psychologie de la Perception (CNRS UMR 8242) , Université Paris Descartes , Paris, France.|f Pôle Hospitalo-Universitaire de Psychiatrie de l'Enfant et de l'Adolescent de Rennes , Université de Rennes 1 , Rennes, France.
authors.forename: S
authors.initials: S
authors.lastname: Tordjman
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001288:Attention / Q000502:physiology*; D002648:Child; D060825:Cognitive Dysfunction / Q000209:etiology / Q000503:physiopathology*; D056344:Executive Function / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000150:complications / Q000503:physiopathology*; D013998:Time Perception / Q000502:physiology*; D055815:Young Adult
keywords: Early-onset schizophrenia; attention; executive functions; temporal overlap; time perception