title: Novel 3,4,7-Substituted Benzofuran Derivatives Having Binding Affinity to κ-Opioid Receptor.
abstract: A series of novel 3,4,7-trisubstituted benzofuran derivatives were synthesized, and their binding affinity to κ- (KOR) and μ-opioid receptors (MOR) were evaluated. Several aryl ethers showed moderate binding activities to KOR (IC50=3.9-11 µM) without binding to MOR.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyoto University.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Nishiyama
authors.forename: Yuki
authors.initials: Y
authors.lastname: Sakai
authors.forename: Haruka
authors.initials: H
authors.lastname: Sekiguchi
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Chiba
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Misu
authors.forename: Shinya
authors.initials: S
authors.lastname: Oishi
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Fujii
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ohno
mesh_terms: D000818:Animals; D001572:Benzofurans / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001665:Binding Sites / Q000187:drug effects; D016466:CHO Cells; D003412:Cricetulus; D004305:Dose-Response Relationship, Drug; D006801:Humans; D015394:Molecular Structure; D017473:Receptors, Opioid, kappa / Q000037:antagonists & inhibitors* / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D001572:Benzofurans; D017473:Receptors, Opioid, kappa