title: Prospective Validation of the Objective Prognostic Score for Advanced Cancer Patients in Diverse Palliative Settings.
abstract: Prognostication is an essential part of palliative care to aid decision making and negotiate goals of care. The Objective Prognostic Score (OPS) is an easy-to-use prognosticating tool to predict survival among far-advanced cancer patients in palliative care units (PCUs) in Korea.
  
  
  
  This study aimed to prospectively validate the OPS for advanced cancer patients in the palliative care teams (PCTs), PCUs, and home-based palliative care (HPC) in Japan.
  
  
  
  This was a substudy of a multicenter prospective cohort study that was conducted to validate and compare prognostic tools among advanced cancer patients in Japan. Participants' survival was calculated according to OPS 3 as a cutoff for predicting survival of less than three weeks. Overall accuracy and area under the receiver operator characteristic curves of OPS 3 were calculated for PCT, PCU, and HPC, respectively.
  
  
  
  A total of 1146 cases (PCTs 441, PCUs 519, and HPCs 186 cases) were included in final analyses. The overall accuracy of OPS 3 for predicting three-week survival ranged from 0.70 to 0.78 across diverse palliative care settings. The c-statistics ranged from 0.742 to 0.808 across three settings. Participants in the PCT showed the highest overall accuracy and c-statistics for OPS.
  
  
  
  The OPS can be used for prognostication among advanced cancer patients in PCT, PCU, and HPC settings.
authors.affiliation: Palliative Care Clinic, Hospital, National Cancer Center, Goyang, South Korea.
authors.forename: Hyun Jung
authors.initials: HJ
authors.lastname: Jho
authors.affiliation: Department of Family Medicine, Dongguk University Ilsan Hospital, Goyang, South Korea; Department of Medicine, School of Medicine, Dongguk University, Seoul, South Korea. Electronic address: lisasuhmd@hotmail.com.
authors.forename: Sang-Yeon
authors.initials: SY
authors.lastname: Suh
authors.affiliation: Department of Family Medicine, Research Institute for Medical Sciences, Chungnam National University School of Medicine, Daejeon, South Korea.
authors.forename: Seok-Joon
authors.initials: SJ
authors.lastname: Yoon
authors.affiliation: Department of Statistics, Dongguk University, Seoul, South Korea.
authors.forename: Sanghee Shiny
authors.initials: SS
authors.lastname: Lee
authors.affiliation: Department of Statistics, Dongguk University, Seoul, South Korea.
authors.forename: Hong-Yup
authors.initials: HY
authors.lastname: Ahn
authors.affiliation: Department of Palliative Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamaguchi
authors.affiliation: Department of Palliative Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Mori
authors.affiliation: Department of Palliative Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.
authors.forename: Isseki
authors.initials: I
authors.lastname: Maeda
authors.affiliation: Department of Palliative Care, Saito Yukoukai Hospital, Osaka, Japan.
authors.forename: Mika
authors.initials: M
authors.lastname: Baba
authors.affiliation: Palliative and Supportive Care Division, Seirei Mikatahara General Hospital, Hamamatsu, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Morita
mesh_terms: D000368:Aged; D019540:Area Under Curve; D015415:Biomarkers / Q000378:metabolism; D005260:Female; D006699:Home Care Services; D006801:Humans; D007564:Japan; D008297:Male; D009369:Neoplasms / Q000175:diagnosis*; D010166:Palliative Care; D010348:Patient Care Team; D011379:Prognosis; D011446:Prospective Studies; D012372:ROC Curve; D016019:Survival Analysis
chemical_list: D015415:Biomarkers
keywords: Cancer; Objective Prognostic Score; palliative care; prognostication; survival