title: Diversity and function of group 1 innate lymphoid cells.
abstract: Innate lymphoid cells (ILCs) are a heterogeneous population of cells with diverse roles in immune responses. Three major groups of ILCs have been defined on the basis of similarity in their production of signature cytokines, developmental requirements, and phenotypic markers. Group 1 ILCs produce IFN-γ, express the T-box transcription factors (TF) T-bet and/or Eomesodermin (Eomes), group 2 ILCs secrete IL-5 and IL-13 and express the TF GATA-3, while group 3 ILCs produce IL-22 and IL-17 and express the TF RORgt. In this review, we will briefly overview each group in terms of phenotype, function and development and then focus more extensively on group 1 ILCs, expanding on their emerging diversity, their disparate functions and the differences between NK cells and ILC1.
authors.affiliation: Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA.
authors.forename: Victor S
authors.initials: VS
authors.lastname: Cortez
authors.affiliation: Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA. Electronic address: mcolonna@pathology.wustl.edu.
authors.forename: Marco
authors.initials: M
authors.lastname: Colonna
mesh_terms: D000818:Animals; D015415:Biomarkers; D002454:Cell Differentiation / Q000235:genetics / Q000276:immunology; D000066670:Cell Plasticity / Q000235:genetics / Q000276:immunology*; D016207:Cytokines / Q000378:metabolism; D004198:Disease Susceptibility; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D007113:Immunity, Innate; D007371:Interferon-gamma / Q000096:biosynthesis; D007694:Killer Cells, Natural / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D016131:Lymphocyte Subsets / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D009928:Organ Specificity; D010641:Phenotype; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D015415:Biomarkers; D016207:Cytokines; D014157:Transcription Factors; D007371:Interferon-gamma
keywords: ILC; Innate immunity; Interferon-gamma; NK cells