title: Hydroxychloroquine, a promising choice for coronary artery disease?
abstract: Coronary artery disease is a common disease that seriously threaten the health of more than 150 million people per year. Atherosclerosis is considered to be the main cause of coronary artery disease which begins with damage or injury to the inner layer of a coronary artery, sometimes as early as childhood. The damage may be caused by various factors, including: smoking, high blood pressure, hypercholesterolemia, sedentary lifestyle, diabetes and insulin resistance. Once a coronary artery disease has developed, all patients need to be treated with long term standard treatment, including heart-healthy lifestyle changes, medicines, and medical procedures or surgery. Hydroxychloroquine, an original antimalarial drug, prevents inflammation caused by lupus erythematosus and rheumatoid arthritis. It is relatively safe and well-tolerated during the treatment. Since atherosclerosis and rheumatoid arthritis have resemble mechanism and increasing clinical researches confirm that hydroxychloroquine has an important role in both anti-rheumatoid arthritis and cardiovascular protection (such as anti-platelet, anti-thrombotic, lipid-regulating, anti-hypertension, hypoglycemia, and so on), we hypothesize that hydroxychloroquine might be a promising choice to coronary artery disease patients for its multiple benefits.
authors.affiliation: Department of Cardiovascular Medicine, First Affiliated Hospital of Medical School, Xi'an Jiaotong University. Xi'an 710061, PR China.
authors.forename: Lizhe
authors.initials: L
authors.lastname: Sun
authors.affiliation: Department of Cardiovascular Medicine, First Affiliated Hospital of Medical School, Xi'an Jiaotong University. Xi'an 710061, PR China.
authors.forename: Mengping
authors.initials: M
authors.lastname: Liu
authors.affiliation: Department of Cardiovascular Medicine, First Affiliated Hospital of Medical School, Xi'an Jiaotong University. Xi'an 710061, PR China.
authors.forename: Ruifeng
authors.initials: R
authors.lastname: Li
authors.affiliation: Department of Cardiovascular Medicine, First Affiliated Hospital of Medical School, Xi'an Jiaotong University. Xi'an 710061, PR China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Department of Cardiovascular Medicine, First Affiliated Hospital of Medical School, Xi'an Jiaotong University. Xi'an 710061, PR China.
authors.forename: Junhui
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Cardiovascular Medicine, First Affiliated Hospital of Medical School, Xi'an Jiaotong University. Xi'an 710061, PR China.
authors.forename: Yanjie
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Cardiovascular Medicine, First Affiliated Hospital of Medical School, Xi'an Jiaotong University. Xi'an 710061, PR China.
authors.forename: Lisha
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Cardiovascular Medicine, First Affiliated Hospital of Medical School, Xi'an Jiaotong University. Xi'an 710061, PR China.
authors.forename: Xiaofang
authors.initials: X
authors.lastname: Bai
authors.affiliation: Department of Cardiovascular Medicine, First Affiliated Hospital of Medical School, Xi'an Jiaotong University. Xi'an 710061, PR China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Wei
authors.affiliation: Department of Cardiovascular Medicine, First Affiliated Hospital of Medical School, Xi'an Jiaotong University. Xi'an 710061, PR China.
authors.forename: Qiangqiang
authors.initials: Q
authors.lastname: Ma
authors.affiliation: Department of Cardiovascular Medicine, First Affiliated Hospital of Medical School, Xi'an Jiaotong University. Xi'an 710061, PR China.
authors.forename: Juan
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Cardiovascular Medicine, First Affiliated Hospital of Medical School, Xi'an Jiaotong University. Xi'an 710061, PR China; Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University, Ministry of Education, Xi'an 710061, PR China. Electronic address: zuyiyuan@mail.xjtu.edu.cn.
authors.forename: Zuyi
authors.initials: Z
authors.lastname: Yuan
authors.affiliation: Department of Cardiovascular Medicine, First Affiliated Hospital of Medical School, Xi'an Jiaotong University. Xi'an 710061, PR China; Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University, Ministry of Education, Xi'an 710061, PR China. Electronic address: imyuewu@gmail.com.
authors.forename: Yue
authors.initials: Y
authors.lastname: Wu
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D003324:Coronary Artery Disease / Q000188:drug therapy*; D004195:Disease Models, Animal; D006801:Humans; D006886:Hydroxychloroquine / Q000627:therapeutic use*; D007249:Inflammation / Q000188:drug therapy; D007333:Insulin Resistance; D008055:Lipids / Q000737:chemistry; D008962:Models, Theoretical; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry; D012307:Risk Factors
chemical_list: D000962:Antimalarials; D008055:Lipids; D010975:Platelet Aggregation Inhibitors; D006886:Hydroxychloroquine
keywords: Atherosclerosis; Coronary artery disease; Hydroxychloroquine