title: Prostate Volume Index Associates with a Decreased Risk of Prostate Cancer: Results of a Large Cohort of Patients Elected to a First Biopsy Set.
abstract: Background/Aims/Objectives: In patients elected to the first prostate biopsy set, the risk of prostate cancer (PCA) may be predicted by clinical factors. The aim of this study was to investigate on prostate volume index (PVI), defined as the ratio of volume of the transitional zone to the volume of the peripheral zone, and PCA risk.
  
  
  METHODS
  The study retrospectively evaluated 1,327 patients and included only the first biopsy set with 14 cores. PCA risk was assessed by using the multivariate logistic regression model.
  
  
  RESULTS
  The analysis evaluated 596 patients. The detection rate of PCA was 49%. Age, prostate specific antigen, PVI and digital rectal exam were independent factors of PCA risk, which was decreased by PVI (OR 0.224; 95% CI 0.157-0.380). The goodness of fit statistics assessed model efficacy.
  
  
  CONCLUSIONS
  In a large cohort undergoing the first biopsy set, PVI associated with a decreased risk of PCA. Confirmatory studies are required.
authors.affiliation: Urologic Clinic, University Hospital, Ospedale Polo Chirurgico Borgo Trento, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
authors.forename: Antonio Benito
authors.initials: AB
authors.lastname: Porcaro
authors.forename: Giovanni
authors.initials: G
authors.lastname: Novella
authors.forename: Giovanni
authors.initials: G
authors.lastname: Cacciamani
authors.forename: Davide
authors.initials: D
authors.lastname: De Marchi
authors.forename: Paolo
authors.initials: P
authors.lastname: Corsi
authors.forename: Nicolò
authors.initials: N
authors.lastname: De Luyk
authors.forename: Leonardo
authors.initials: L
authors.lastname: Bizzotto
authors.forename: Tania
authors.initials: T
authors.lastname: Processali
authors.forename: Mattia
authors.initials: M
authors.lastname: Cerasuolo
authors.forename: Irene
authors.initials: I
authors.lastname: Tamanini
authors.forename: Maria Angela
authors.initials: MA
authors.lastname: Cerruto
authors.forename: Matteo
authors.initials: M
authors.lastname: Brunelli
authors.forename: Salvatore
authors.initials: S
authors.lastname: Siracusano
authors.forename: Walter
authors.initials: W
authors.lastname: Artibani
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D018579:Patient Selection; D011467:Prostate / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000473:pathology*; D012189:Retrospective Studies; D012307:Risk Factors