title: Inhibitory effect of alpha-mangostin on Candida biofilms.
abstract: The objective of this study was to determine the inhibitory effect of alpha-mangostin on Candida biofilms. Candida species including Candida albicans, Candida krusei, Candida tropicalis, and Candida glabrata were tested. Candida biofilms were formed in flat-bottomed 96-well microtiter plates. The metabolic activity of cells within biofilms was quantified using the XTT assay. The results demonstrated that alpha-mangostin showed a significant anti-biofilm effect on both developing biofilms and preformed biofilms of Candida species. It may be concluded that alpha-mangostin could be an anti-biofilm agent against Candida species. Further in vivo investigations are needed to uncover the therapeutic values of this medicinal plant.
authors.affiliation: Department of Oral Diagnosis, Faculty of Dentistry, Naresuan University, Phitsanulok, 65000, Thailand. ruchadapornk@nu.ac.th.
authors.forename: Ruchadaporn
authors.initials: R
authors.lastname: Kaomongkolgit
authors.affiliation: Faculty of Dentistry, Dental Science Research Center, Naresuan University, Phitsanulok, 65000, Thailand.
authors.forename: Kusuma
authors.initials: K
authors.lastname: Jamdee
mesh_terms: D018441:Biofilms / Q000187:drug effects*; D002175:Candida / Q000187:drug effects*; D066298:In Vitro Techniques; D010936:Plant Extracts / Q000494:pharmacology*; D044004:Xanthones
chemical_list: D010936:Plant Extracts; D044004:Xanthones; C021053:mangostin
keywords: Alpha-mangostin; Anti-biofilm; Candida species