title: Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses.
abstract: In this review, we discuss the importance of capsaicin to the current understanding of neuronal modulation of pain and explore the mechanisms of capsaicin-induced pain. We will focus on the analgesic effects of capsaicin and its clinical applicability in treating pain. Furthermore, we will draw attention to the rationale for other clinical therapeutic uses and implications of capsaicin in diseases such as obesity, diabetes, cardiovascular conditions, cancer, airway diseases, itch, gastric, and urological disorders.
authors.affiliation: Departamento de Ci&#234;ncias Patol&#243;gicas, Centro de Ci&#234;ncias Biol&#243;gicas, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid KM480 PR445, Caixa Postal 10.011, 86057-970 Londrina, Paran&#225;, Brazil. vfattori@outlook.com.
authors.forename: Victor
authors.initials: V
authors.lastname: Fattori
authors.affiliation: Departamento de Ci&#234;ncias Patol&#243;gicas, Centro de Ci&#234;ncias Biol&#243;gicas, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid KM480 PR445, Caixa Postal 10.011, 86057-970 Londrina, Paran&#225;, Brazil. hohmann.miriam@gmail.com.
authors.forename: Miriam S N
authors.initials: MS
authors.lastname: Hohmann
authors.affiliation: Departamento de Ci&#234;ncias Patol&#243;gicas, Centro de Ci&#234;ncias Biol&#243;gicas, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid KM480 PR445, Caixa Postal 10.011, 86057-970 Londrina, Paran&#225;, Brazil. anacrossaneis@gmail.com.
authors.forename: Ana C
authors.initials: AC
authors.lastname: Rossaneis
authors.affiliation: Departamento de Ci&#234;ncias Patol&#243;gicas, Centro de Ci&#234;ncias Biol&#243;gicas, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid KM480 PR445, Caixa Postal 10.011, 86057-970 Londrina, Paran&#225;, Brazil. pinho.fe@gmail.com.
authors.forename: Felipe A
authors.initials: FA
authors.lastname: Pinho-Ribeiro
authors.affiliation: Departamento de Ci&#234;ncias Patol&#243;gicas, Centro de Ci&#234;ncias Biol&#243;gicas, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid KM480 PR445, Caixa Postal 10.011, 86057-970 Londrina, Paran&#225;, Brazil. waverri@uel.br.
authors.forename: Waldiceu A
authors.initials: WA
authors.lastname: Verri
mesh_terms: D000700:Analgesics / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D002211:Capsaicin / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use*; D002212:Capsicum / Q000737:chemistry; D000068456:Clinical Studies as Topic; D004339:Drug Compounding; D004353:Drug Evaluation, Preclinical; D058492:Drug Repositioning; D006801:Humans; D009619:Nociceptors / Q000187:drug effects / Q000378:metabolism; D010146:Pain / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000700:Analgesics; D010936:Plant Extracts; D002211:Capsaicin
keywords: TRPV1; analgesia; capsaicinoids; chili peppers; desensitization