title: Long-term outcome for patients with early stage marginal zone lymphoma and mantle cell lymphoma.
abstract: In this study with prolonged follow up, we compared clinical outcome, including cause of death and incidence of second cancer, for patients with early stage extranodal marginal zone lymphoma (EMZL, 49 patients), nodal marginal zone lymphoma (NMZL, nine patients) and mantle cell lymphoma (MCL, 42 patients) with emphasis on potential benefit of radiotherapy. Radiotherapy was given to 40 patients with EMZL (nine had surgery only) and all NMZL patients. MCL patients received radiotherapy (17 patients), chemotherapy followed by radiotherapy (13 patients) or chemotherapy alone (12 patients). Compared to a matched control population no increased risk of second cancer or cardiovascular disease was observed. Radiotherapy alone was effective in EMZL and NMZL with low-relapse rates (20% and 33%) and a 10-year overall survival of 78% and 56%, respectively. High-relapse rate and inferior OS in MCL underline the need for extended staging with endoscopy and PET/CT and possibly for novel strategies.
authors.affiliation: a Department of Oncology , Ostfold Hospital Trust , Kalnes , Norway.
authors.forename: Dlawer Abdulla
authors.initials: DA
authors.lastname: Barzenje
authors.affiliation: b Department of Oncology , Oslo University Hospital , Oslo , Norway.
authors.forename: Harald
authors.initials: H
authors.lastname: Holte
authors.affiliation: b Department of Oncology , Oslo University Hospital , Oslo , Norway.
authors.forename: Alexander
authors.initials: A
authors.lastname: Fosså
authors.affiliation: c Department of Medicine , Ostfold Hospital Trust , Kalnes , Norway.
authors.forename: Waleed
authors.initials: W
authors.lastname: Ghanima
authors.affiliation: d Department of Biostatistics , Oslo University Hospital , Oslo , Norway.|e Center for Cancer Biomedicine, University of Oslo , Oslo , Norway.
authors.forename: Knut
authors.initials: K
authors.lastname: Liestøl
authors.affiliation: f Department of Pathology , Oslo University Hospital , Oslo , Norway.
authors.forename: Jan
authors.initials: J
authors.lastname: Delabie
authors.affiliation: b Department of Oncology , Oslo University Hospital , Oslo , Norway.
authors.forename: Arne
authors.initials: A
authors.lastname: Kolstad
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002423:Cause of Death; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D015994:Incidence; D018442:Lymphoma, B-Cell, Marginal Zone / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy; D020522:Lymphoma, Mantle-Cell / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D016609:Neoplasms, Second Primary / Q000453:epidemiology / Q000209:etiology; D009664:Norway / Q000453:epidemiology; D063868:Patient Outcome Assessment; D011159:Population Surveillance; D016019:Survival Analysis; D016896:Treatment Outcome
keywords: Marginal zone lymphoma; early stage; mantle cell lymphoma; radiotherapy