title: Biomimetic cardiovascular stents for in vivo re-endothelialization.
abstract: The use of cardiovascular stents for rapid in vivo re-endothelialization is a promising strategy for reducing cardiovascular implantation or preventing local thrombus formation and restenosis. Surface-patterned intravascular endoprosthetic stents have been developed to prevent life-threatening complications. In this study, vascular smooth muscle cell (VSMC)-biomimetic surface patterns were fabricated on 316L cardiovascular stents using a femtosecond laser and then implanted into the iliac artery of rabbit. The in vitro data revealed that the bionic surface patterns matched the morphology of the VSMCs well, which promotes the adhesion, proliferation, and migration of human umbilical vein endothelial cells. In addition, the patterned surfaces can significantly enhance re-endothelialization. Consequently, the surface biomimetic stent with the VSMC surface pattern is likely an effective approach to ensure rapid re-endothelialization and possibly reduce the incidence of in-stent restenosis.
authors.affiliation: Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology, School of Materials Science and Engineering, Research Institute for Energy Equipment Materials, Hebei University of Technology, Tianjin 300130, China. Electronic address: liangchunyong@126.com.
authors.forename: Chunyong
authors.initials: C
authors.lastname: Liang
authors.affiliation: Tianjin Chest Hospital, Tianjin 300051, China.
authors.forename: Yuecheng
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology, School of Materials Science and Engineering, Research Institute for Energy Equipment Materials, Hebei University of Technology, Tianjin 300130, China.
authors.forename: Hongshui
authors.initials: H
authors.lastname: Wang
authors.affiliation: Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology, School of Materials Science and Engineering, Research Institute for Energy Equipment Materials, Hebei University of Technology, Tianjin 300130, China; Centre for DNA Nanotechnology, Interdisciplinary Nanoscience Center, Aarhus University, Aarhus 8000, Denmark.
authors.forename: Dan
authors.initials: D
authors.lastname: Xia
authors.affiliation: Centre for DNA Nanotechnology, Interdisciplinary Nanoscience Center, Aarhus University, Aarhus 8000, Denmark.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.affiliation: Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology, School of Materials Science and Engineering, Research Institute for Energy Equipment Materials, Hebei University of Technology, Tianjin 300130, China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Institute of Modern Optics, Nankai University, Tianjin 300071, China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Yang
authors.affiliation: Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology, School of Materials Science and Engineering, Research Institute for Energy Equipment Materials, Hebei University of Technology, Tianjin 300130, China.
authors.forename: Baoe
authors.initials: B
authors.lastname: Li
authors.affiliation: Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology, School of Materials Science and Engineering, Research Institute for Energy Equipment Materials, Hebei University of Technology, Tianjin 300130, China.
authors.forename: Haipeng
authors.initials: H
authors.lastname: Li
authors.affiliation: National Center for Nanoscience and Technology, Beijing 100190, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Han
authors.affiliation: Centre for DNA Nanotechnology, Interdisciplinary Nanoscience Center, Aarhus University, Aarhus 8000, Denmark. Electronic address: dong@inano.au.dk.
authors.forename: Mingdong
authors.initials: M
authors.lastname: Dong
mesh_terms: D000818:Animals; D040761:Biomimetic Materials / Q000737:chemistry*; D001807:Blood Vessel Prosthesis; D004730:Endothelium, Vascular / Q000166:cytology* / Q000254:growth & development*; D019544:Equipment Failure Analysis; D048091:Guided Tissue Regeneration / Q000295:instrumentation*; D008297:Male; D011474:Prosthesis Design; D011817:Rabbits; D015607:Stents
keywords: Biomimetic surface pattern; Cardiovascular stent; Femtosecond laser; Re-endothelialization