title: Evidence for miR-17-92 and miR-134 gene cluster regulation of ovarian cancer drug resistance.
abstract: Ovarian cancer treatments are often impeded by drug resistance. It has been proposed that microRNA (miRNA) expression patterns may play a role in drug resistance among ovarian cancers. The present study investigated the relationship between resistance to the cancer drug paclitaxel and miRNA expression.
  
  
  
  We compared the expression patterns of miRNA genes in paclitaxel-sensitive (SKOV3) and paclitaxel-resistant (SKOV3-TR30) cell lines.
  
  
  
  Expression of the miR-134 gene cluster was found to be significantly lower in the paclitaxel-resistant cell line than in the paclitaxel-sensitive cell line, while the expression of the miR-17-92 gene cluster was significantly higher in the paclitaxel-resistant cells. An analysis of miRNA target gene protein expression revealed that several targets of miR-17-92 were significantly altered between the two cell types.
  
  
  
  The higher expression of miR-17-92 and lower expression of mi-134 and the associated alterations of target gene expression may be associated with the drug-resistant nature of some ovarian cancers.
authors.affiliation: Department of Obstetrics and Gynecology, The Forth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, P. R. China. hsy0451@126.com.
authors.forename: H
authors.initials: H
authors.lastname: Zhu
authors.forename: S-Y
authors.initials: SY
authors.lastname: Yang
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.forename: S-Y
authors.initials: SY
authors.lastname: Han
mesh_terms: D045744:Cell Line, Tumor; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D005810:Multigene Family; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000235:genetics*; D062085:RNA, Long Noncoding
chemical_list: C568997:MIR17HG, human; C569273:MIRN134 microRNA, human; D035683:MicroRNAs; D062085:RNA, Long Noncoding