title: Asymmetric Synthesis of CF3- and Indole-Containing Thiochromanes via a Squaramide-Catalyzed Michael-Aldol Reaction.
abstract: A Michael-aldol reaction of 2-mercaptobenzaldehyde with β-indole-β-CF3 enones catalyzed by a squaramide has been realized. The method affords a series of 2-CF3-2-indole-substituted thiochromanes featuring a CF3-containing quaternary stereocenter in excellent yields, diastereoselectivities, and enantioselectivities.
authors.affiliation: The Institute of Pharmacology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic, Medical Sciences, Lanzhou University , Lanzhou 730000, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: The Institute of Pharmacology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic, Medical Sciences, Lanzhou University , Lanzhou 730000, China.
authors.forename: Zhenghao
authors.initials: Z
authors.lastname: Dong
authors.affiliation: The Institute of Pharmacology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic, Medical Sciences, Lanzhou University , Lanzhou 730000, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Cheng
authors.affiliation: The Institute of Pharmacology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic, Medical Sciences, Lanzhou University , Lanzhou 730000, China.
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Zhong
authors.affiliation: The Institute of Pharmacology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic, Medical Sciences, Lanzhou University , Lanzhou 730000, China.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Liu
authors.affiliation: The Institute of Pharmacology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic, Medical Sciences, Lanzhou University , Lanzhou 730000, China.
authors.forename: Li
authors.initials: L
authors.lastname: Lin
authors.affiliation: State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences , Lanzhou 730000, China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Shen
authors.affiliation: State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences , Lanzhou 730000, China.
authors.forename: Peiju
authors.initials: P
authors.lastname: Yang
authors.affiliation: The People's Hospital of Gansu Province , Lanzhou 730000, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.affiliation: The People's Hospital of Gansu Province , Lanzhou 730000, China.
authors.forename: Hailin
authors.initials: H
authors.lastname: Wang
authors.affiliation: The Institute of Pharmacology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic, Medical Sciences, Lanzhou University , Lanzhou 730000, China.
authors.forename: Wenjin
authors.initials: W
authors.lastname: Yan
authors.affiliation: The Institute of Pharmacology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic, Medical Sciences, Lanzhou University , Lanzhou 730000, China.
authors.forename: Kairong
authors.initials: K
authors.lastname: Wang
authors.affiliation: The Institute of Pharmacology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic, Medical Sciences, Lanzhou University , Lanzhou 730000, China.|State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences , Lanzhou 730000, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Wang