title: Positive effect of HPV status on prognostic value of blood lymphocyte-to-monocyte ratio in advanced cervical carcinoma.
abstract: BACKGROUND
  This retrospective study aimed to investigate the prognostic significance of pretreatment lymphocyte-to-monocyte ratio (LMR) in locally advanced cervical cancer and its effect on overall survival.
  
  
  METHODS
  The usual blood routine test was quantitatively performed to detect LMR. Signal strengths of human papilloma virus (HPV) type DNA in detected cervical cancer samples using hybrid capture 2 were analyzed in relative light units (RLU) compared with 1 pg/mL of HPV type 16 DNA-positive control (RLU/PC) samples. A total of 1.0 RLU/PC (~1 pg/mL) was used as the threshold for a positive result. The HPV-positive specimens were typed using reverse-hybridization line probe assay.
  
  
  RESULTS
  The LMR and HPV DNA were found to be independent prognostic markers for 5-year overall survival (OS) and progression-free survival, respectively. Their joint detection may further enhance the predictive value for OS. In the positive HR (high risk)-HPV DNA status subgroup, LMR had a positive effect on improved OS but not in the non-HR HPV DNA status subgroup.
  
  
  CONCLUSIONS
  The LMR and HR-HPV DNA status can be identified as independent prognostic factors. The different influences of LMR in combined chemoradiotherapy on survival may be related to HR-HPV DNA status. The combined detection of LMR and HR-HPV DNA status may contribute to screening prognosis.
authors.affiliation: Department of Radiation Oncology, the Affiliated Hospital of Guilin Medical University, Guilin, 541004 People's Republic of China.
authors.forename: Si-Wei
authors.initials: SW
authors.lastname: Li
authors.affiliation: Department of Ultrasonography, the First Affiliated Hospital, Nanchang University, Nanchang, People's Republic of China.
authors.forename: Wenxin
authors.initials: W
authors.lastname: Yuan
authors.affiliation: Department of Radiation Oncology, the Affiliated Hospital of Guilin Medical University, Guilin, 541004 People's Republic of China.
authors.forename: Bo
authors.initials: B
authors.lastname: Zhao
authors.affiliation: Department of Radiation Oncology, the Affiliated Hospital of Guilin Medical University, Guilin, 541004 People's Republic of China.
authors.forename: Zhuo-Kai
authors.initials: ZK
authors.lastname: He
authors.affiliation: Department of Nasopharyngeal Carcinoma, State Key Laboratory of Oncology in Southern China, Guangzhou, 510060 People's Republic of China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Guo
authors.affiliation: Department of Nasopharyngeal Carcinoma, State Key Laboratory of Oncology in Southern China, Guangzhou, 510060 People's Republic of China.
authors.forename: Wei-Xiong
authors.initials: WX
authors.lastname: Xia
authors.affiliation: Department of Hematology, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510230 People's Republic of China.|Guangdong Key Laboratory of Urology, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong People's Republic of China.
authors.forename: Li-Hua
authors.identifier: 0000-0002-3437-1286
authors.initials: LH
authors.lastname: Xu
keywords: Cervical carcinoma; Human papilloma virus; Hybrid capture 2; Lymphocyte to monocyte ratio; Prognosis