title: [Not Available].
abstract: The use of amikacin is difficult because of its toxicity and its pharmacokinetic variability. This variability is almost ignored in adult standard dosage regimens since only the weight is used in the dose calculation. Our objective is to test if the pharmacokinetic of amikacin can be regarded as homogenous, and if the method for calculating the dose according to patients' weight is appropriate. From a cohort of 580 patients, five groups of patients were created by statistical data partitioning. A population pharmacokinetic analysis was performed in each group. The adult population is not homogeneous in term of pharmacokinetics. The doses required to achieve a maximum concentration of 60mg/L are strongly different (585 to 1507mg) between groups. The exclusive use of the weight to calculate the dose of amikacine appears inappropriate for 80% of the patients, showing the limits of the formulae for calculating doses of aminoglycosides.
authors.affiliation: Université de Lyon 1, ÉcoleDoctorale E2M2 «Évolution, Écosystèmes, Microbiologie, Modélisation», UMR 5558, «Biométrie et Biologie Évolutive », Villeurbanne, France; Hospices Civils de Lyon, Hôpital Antoine Charial, Service Pharmacie, Francheville, France; ADCAPT, Hôpital Antoine Charial, Service Pharmacie, Francheville, France. Electronic address: laurent.bourguignon@chu-lyon.fr.
authors.forename: Laurent
authors.initials: L
authors.lastname: Bourguignon
authors.affiliation: Université de Lyon 1, ÉcoleDoctorale E2M2 «Évolution, Écosystèmes, Microbiologie, Modélisation», UMR 5558, «Biométrie et Biologie Évolutive », Villeurbanne, France; Hospices Civils de Lyon, Hôpital Antoine Charial, Service Pharmacie, Francheville, France; ADCAPT, Hôpital Antoine Charial, Service Pharmacie, Francheville, France.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Goutelle
authors.affiliation: ADCAPT, Hôpital Antoine Charial, Service Pharmacie, Francheville, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Gérard
authors.affiliation: ADCAPT, Hôpital Antoine Charial, Service Pharmacie, Francheville, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Guillermet
authors.affiliation: ADCAPT, Hôpital Antoine Charial, Service Pharmacie, Francheville, France.
authors.forename: Julie Burdin
authors.initials: JB
authors.lastname: de Saint Martin
authors.affiliation: Université de Lyon 1, ÉcoleDoctorale E2M2 «Évolution, Écosystèmes, Microbiologie, Modélisation», UMR 5558, «Biométrie et Biologie Évolutive », Villeurbanne, France; Hospices Civils de Lyon, Hôpital Antoine Charial, Service Pharmacie, Francheville, France; ADCAPT, Hôpital Antoine Charial, Service Pharmacie, Francheville, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Maire
authors.affiliation: Hospices Civils de Lyon, Hôpital Antoine Charial, Service Pharmacie, Francheville, France; ADCAPT, Hôpital Antoine Charial, Service Pharmacie, Francheville, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Ducher
keywords: amikacin; amikacine; calcul de dose; drug dosage calculations; pharmacocinétique; pharmacokinetics