title: Effects of two different exercise programs on chronic fatigue in lupus patients.
abstract: OBJECTIVE
  Fatigue is a major complaint of patients with systemic lupus erythemasosus (SLE). While several studies have demonstrated the benefits of exercise, the effects of supervised training were never compared to those of home training.
  
  
  METHODS
  Forty-five SLE patients suffering from fatigue, as defined by Krupp's fatigue severity scale (FSS) ≥ 3.7, were randomized in 3 groups: supervised training group (STG), home training group (HTG), and control group (CG). Primary outcome was the change in FSS at month 3. In parallel, we measured the physical working capacity measured at 75% of the predicted maximal heart rate (PWC75%/kg) and the modified Borg's scale to assess perception of exertion.
  
  
  RESULTS
  Both STG and HTG, but not the CG, statistically improved their FSS at month 3. By contrast, the PWC75%/kg and the Borg's scale did not improve in none of the groups. Surprinsingly, compliance was similar and low (±50%) in both exercise groups. Moreover, less compliant patients improved their fatigue as much as more compliant patients.
  
  
  CONCLUSIONS
  Patients included in the STG and the HTG similarly improved their fatigue, irrespectively of their level of compliance, raising the possibility that the beneficial effect on fatigue was not only exercise-related.
authors.affiliation: a Rehabilitation Department, Pôle de Réadaptation, Institute of Neurosciences , Cliniques Universitaires Saint-Luc , Bruxelles , Belgium.
authors.forename: Marie
authors.initials: M
authors.lastname: Avaux
authors.affiliation: a Rehabilitation Department, Pôle de Réadaptation, Institute of Neurosciences , Cliniques Universitaires Saint-Luc , Bruxelles , Belgium.
authors.forename: Pauline
authors.initials: P
authors.lastname: Hoellinger
authors.affiliation: b Rheumatology Department, Pôle de Pathologies Rhumatismales Inflammatoires et Systémiques , Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain , Bruxelles , Belgium.
authors.forename: Séverine
authors.initials: S
authors.lastname: Nieuwland-Husson
authors.affiliation: a Rehabilitation Department, Pôle de Réadaptation, Institute of Neurosciences , Cliniques Universitaires Saint-Luc , Bruxelles , Belgium.
authors.forename: Virginie
authors.initials: V
authors.lastname: Fraselle
authors.affiliation: b Rheumatology Department, Pôle de Pathologies Rhumatismales Inflammatoires et Systémiques , Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain , Bruxelles , Belgium.
authors.forename: Geneviève
authors.initials: G
authors.lastname: Depresseux
authors.affiliation: b Rheumatology Department, Pôle de Pathologies Rhumatismales Inflammatoires et Systémiques , Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain , Bruxelles , Belgium.
authors.forename: Frédéric A
authors.initials: FA
authors.lastname: Houssiau
mesh_terms: D000328:Adult; D002908:Chronic Disease; D015444:Exercise / Q000502:physiology*; D005081:Exercise Therapy / Q000379:methods*; D005221:Fatigue / Q000209:etiology / Q000503:physiopathology / Q000534:rehabilitation*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000503:physiopathology / Q000534:rehabilitation; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D011788:Quality of Life; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome
keywords: Exercise; Fatigue; Lupus