title: The effect of a platelet-rich fibrin conduit on neurosensory recovery following inferior alveolar nerve lateralization: a preliminary clinical study.
abstract: This retrospective study aimed to assess the recovery of neurosensory dysfunction following modified inferior alveolar nerve (IAN) lateralization surgery compared to the conventional approach. Data from two groups of patients who underwent IAN lateralization in 2014 were included in this study. In one group, platelet-rich fibrin was placed over the IAN and this was protected with a collagen membrane conduit; the other group underwent the conventional IAN lateralization procedure. Implants were placed immediately. Neurosensory dysfunction was evaluated at 3, 6, and 12 months post-surgery. Demographic, neurosensory disturbance (NSD), subjective two-point discrimination test (TPD), and static light touch test (SLT) data were obtained. Twenty-three IAN lateralization procedures with the placement of 51 implants were performed in 14 patients. At the 6-month follow-up, the number of patients experiencing normal sensation was greater in the modified surgery group, but the 12-month follow-up results were the same in the two groups. More precise sensation was observed with the TPD in the modified group at 6 months, and the modified group demonstrated better SLT scores at 6 months. Although the two groups had comparable results at the 12-month follow-up, it was observed that the modified technique accelerated neural healing within 6 months and reduced the length of the discomfort period.
authors.affiliation: School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; School of Medicine, University of Antwerp, Antwerp, Belgium. Electronic address: arashkhojasteh@sbmu.ac.ir.
authors.forename: A
authors.initials: A
authors.lastname: Khojasteh
authors.affiliation: Student Research Committee, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: S
authors.initials: S
authors.lastname: Hosseinpour
authors.affiliation: Research Institute of Dental Sciences, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: P
authors.initials: P
authors.lastname: Nazeman
authors.affiliation: Department of Surgery and Radiology, Centre of Excellence for Cell Therapy and Tissue Engineering, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
authors.forename: M M
authors.initials: MM
authors.lastname: Dehghan
mesh_terms: D000328:Adult; D003757:Dental Implantation; D005260:Female; D006801:Humans; D008297:Male; D008340:Mandibular Nerve / Q000601:surgery*; D008875:Middle Aged; D000073183:Platelet-Rich Fibrin; D020127:Recovery of Function; D012189:Retrospective Studies; D012677:Sensation; D013997:Time Factors
keywords: alveolar bone loss; dental implants; mandibular nerve; somatosensory disorders