title: Poly Ethoxy Ethyl Glycinamide (PEE-G) Dendrimers: Dendrimers Specifically Designed for Pharmaceutical Applications.
abstract: Poly ethoxy ethyl glycinamide (PEE-G) dendrimers have been specifically designed and synthesized with the aim of providing a readily available dendrimer scaffold that can be used to make products that can meet the stringent requirements of pharmaceutical applications. The synthesis has been refined to produce dendrimers that are of high HPLC purity. The suitability of PEE-G dendrimers for their designed use has been verified by subsequent measurements to demonstrate that they are of high stability, high aqueous solubility, low cytotoxicity, low immunogenicity and with low in vivo toxicity in an escalating-dose rat study. PEE-G dendrimers therefore provide a useful scaffold for researchers wanting to develop dendrimer-based drug candidates.
authors.affiliation: Callaghan Innovation, PO Box 31 310, Lower Hutt, 5040, New Zealand.
authors.forename: Steven
authors.initials: S
authors.lastname: Toms
authors.affiliation: Victoria University of Wellington, PO Box 33 436, Petone, 5046, New Zealand.
authors.forename: Susan M
authors.initials: SM
authors.lastname: Carnachan
authors.affiliation: Malaghan Institute of Medical Research, PO Box 7060, Wellington, 6242, New Zealand.
authors.forename: Ian F
authors.initials: IF
authors.lastname: Hermans
authors.affiliation: Callaghan Innovation, PO Box 31 310, Lower Hutt, 5040, New Zealand.
authors.forename: Keryn D
authors.initials: KD
authors.lastname: Johnson
authors.affiliation: Callaghan Innovation, PO Box 31 310, Lower Hutt, 5040, New Zealand.
authors.forename: Ashna A
authors.initials: AA
authors.lastname: Khan
authors.affiliation: Centre for Integrated Preclinical Drug Development, Faculty of Medicine and Biomedical Sciences, The University of Queensland, St. Lucia Campus, QLD, 4072, Australia.
authors.forename: Suzanne E
authors.initials: SE
authors.lastname: O'Hagan
authors.affiliation: Malaghan Institute of Medical Research, PO Box 7060, Wellington, 6242, New Zealand.
authors.forename: Ching-Wen
authors.initials: CW
authors.lastname: Tang
authors.affiliation: Victoria University of Wellington, PO Box 33 436, Petone, 5046, New Zealand. Phillip.rendle@vuw.ac.nz.
authors.forename: Phillip M
authors.identifier: 0000-0002-2825-8746
authors.initials: PM
authors.lastname: Rendle
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D050091:Dendrimers / Q000138:chemical synthesis* / Q000633:toxicity; D055808:Drug Discovery; D005260:Female; D008297:Male; D008810:Mice, Inbred C57BL; D017207:Rats, Sprague-Dawley; D012756:Sheep; D013154:Spleen / Q000166:cytology / Q000187:drug effects
chemical_list: D050091:Dendrimers
keywords: dendrimers; drug discovery; purity; stability; toxicity