title: Traxoprodil augments the antidepressant-like activity of agomelatine but not of mianserin or tianeptine in the forced swim test in mice.
abstract: BACKGROUND
  The main objective of our study was to evaluate the influence of traxoprodil on the activity of the atypical antidepressant drugs (agomelatine, mianserin, tianeptine).
  
  
  METHODS
  The forced swim test (FST) in mice was used to determine the antidepressant-like activity of the tested agents. Drugs levels in brain tissue were assessed by a high performance liquid chromatography method.
  
  
  RESULTS
  Concurrent intraperitoneal administration of per se ineffective doses of traxoprodil (10mg/kg) and agomelatine (20mg/kg) shortened the immobility time of animals in the FST. The observed effect was associated with elevated brain levels of traxoprodil. Similar interaction was not detected for traxoprodil and mianserin (10mg/kg) or tianeptine (15mg/kg).
  
  
  CONCLUSIONS
  Traxoprodil-agomelatine interaction is pharmacokinetic in nature. A combination of these agents has a potential to become an interesting strategy in the treatment of depression.
authors.affiliation: Department of Human Physiology, Medical University of Lublin, Lublin, Poland.
authors.forename: Weronika
authors.initials: W
authors.lastname: Stasiuk
authors.affiliation: Department of Applied Pharmacy, Medical University of Lublin, Lublin, Poland. Electronic address: anna.serefko@umlub.pl.
authors.forename: Anna
authors.initials: A
authors.lastname: Serefko
authors.affiliation: Department of Applied Pharmacy, Medical University of Lublin, Lublin, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Szopa
authors.affiliation: Department of Pharmacokinetics and Physical Pharmacy, Collegium Medicum, Jagiellonian University, Kraków, Poland.
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Wyska
authors.affiliation: Department of Applied Pharmacy, Medical University of Lublin, Lublin, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Świąder
authors.affiliation: Department of Animal Physiology, Institute of Biology and Biochemistry, Faculty of Biology and Biotechnology, Maria Curie-Skłodowska University, Lublin, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Wlaź
authors.affiliation: Department of Applied Pharmacy, Medical University of Lublin, Lublin, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Poleszak
mesh_terms: D000081:Acetamides / Q000494:pharmacology*; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects; D003863:Depression / Q000188:drug therapy*; D003866:Depressive Disorder / Q000188:drug therapy*; D004357:Drug Synergism; D008297:Male; D008803:Mianserin / Q000494:pharmacology*; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010880:Piperidines / Q000494:pharmacology*; D013550:Swimming / Q000502:physiology; D013841:Thiazepines / Q000494:pharmacology*; D009281:Naphthalenes
chemical_list: D000081:Acetamides; D000928:Antidepressive Agents; D008803:Mianserin; D010880:Piperidines; D013841:Thiazepines; C050504:tianeptine; C084711:agomelatine; D009281:Naphthalenes; C095106:traxoprodil mesylate
keywords: Agomelatine; Forced swim test; Mianserin; Tianeptine; Traxoprodil