title: Effects of the Polysaccharide from the Sporophyll of Brown Alga Undaria Pinnatifida on Serum Lipid Profile and Fat Tissue Accumulation in Rats Fed a High-Fat Diet.
abstract: We investigated the effects of the polysaccharide from the sporophyll of a selected brown alga Undaria pinnatifida on serum lipid profile, fat tissue accumulation, and gastrointestinal transit time in rats fed a high-fat diet. The algal polysaccharide (AP) was prepared by the treatment of multiple cellulase-producing fungi Trichoderma reesei and obtained from the sporophyll with a yield of 38.7% (dry basis). The AP was mostly composed of alginate and fucoidan (up to 89%) in a ratio of 3.75:1. The AP was added to the high-fat diet in concentrations of 0.6% and 1.7% and was given to male Sprague-Dawley rats (5-wk-old) for 5 wk. The 1.7% AP addition notably reduced body weight gain and fat tissue accumulation, and it improved the serum lipid profile, including triglycerides, total cholesterol, and very low-density lipoprotein-cholesterol. The effects were associated with increased feces weight and shortened gastrointestinal transit time. In addition, the lipid peroxidation of the liver was decreased in both groups.
authors.affiliation: Div. of Biotechnology, College of Life Sciences and Biotechnology, Korea Univ, Seoul, 136-713, Republic of Korea.|Div. of Strategic Food Industry Research, Korea Food Research Inst, Seongnam, 463-763, Republic of Korea.
authors.forename: Byoung-Mok
authors.initials: BM
authors.lastname: Kim
authors.affiliation: Div. of Strategic Food Industry Research, Korea Food Research Inst, Seongnam, 463-763, Republic of Korea.
authors.forename: Jae-Ho
authors.initials: JH
authors.lastname: Park
authors.affiliation: Jeonbuk Inst. for Bioindustry, Jeonju 561-360, Republic of Korea.
authors.forename: Dong-Soo
authors.initials: DS
authors.lastname: Kim
authors.affiliation: Gi-jang Mulsan Co. Ltd, Busan, 619-911, Republic of Korea.
authors.forename: Young-Myung
authors.initials: YM
authors.lastname: Kim
authors.affiliation: Dept. of Marine Food Science and Technology, Korea Food Research Institute, Republic of Korea.
authors.forename: Joon-Young
authors.initials: JY
authors.lastname: Jun
authors.affiliation: Dept. of Marine Food Science and Technology, Gangneung-Wonju Natl. Univ, Gangneung, 210-702, Republic of Korea.
authors.forename: In-Hak
authors.initials: IH
authors.lastname: Jeong
authors.affiliation: Div. of Biotechnology, College of Life Sciences and Biotechnology, Korea Univ, Seoul, 136-713, Republic of Korea.
authors.forename: Young-Min
authors.initials: YM
authors.lastname: Chi
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000464:Alginates / Q000032:analysis / Q000494:pharmacology; D000818:Animals; D002784:Cholesterol / Q000097:blood; D059305:Diet, High-Fat; D004041:Dietary Fats / Q000378:metabolism*; D005772:Gastrointestinal Transit / Q000187:drug effects; D020723:Glucuronic Acid / Q000032:analysis / Q000494:pharmacology; D006603:Hexuronic Acids / Q000032:analysis / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D008055:Lipids / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D028321:Plant Preparations / Q000737:chemistry / Q000494:pharmacology*; D018514:Plant Structures; D011134:Polysaccharides / Q000032:analysis / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood; D044648:Undaria / Q000737:chemistry*; D015430:Weight Gain / Q000187:drug effects
chemical_list: D000464:Alginates; D004041:Dietary Fats; D006603:Hexuronic Acids; D008055:Lipids; D008077:Lipoproteins, LDL; D028321:Plant Preparations; D011134:Polysaccharides; D014280:Triglycerides; D020723:Glucuronic Acid; C007789:fucoidan; D002784:Cholesterol
keywords: algal dietary fiber; cellulase-producing fungi; high-fat diet; marine algae; rat