title: [Analysis of treatment and prognosis in post-operative patients with urachal carcinoma].
abstract: OBJECTIVE
  Urachal carcinoma is a kind of urogenital tract malignancy with a very low incidence. The objective of this study was to observe the clinical presentation, pathological condition, treatment method and outcome of patients with urachal carcinoma.
  
  
  METHODS
  A retrospective analysis of thirty-six cases of urachal carcinoma diagnosed over a period of 10 years from 2003 to 2013 was carried out. All pathologic specimens were reviewed by two separate pathologists. Clinical and histological features, treatment condition, patient follow-up and survival outcome was reviewed and calculated.
  
  
  RESULTS
  The mean age at diagnosis was 53 years. Of the thirty-six patients, twenty-five were male. All patients underwent partial cystectomy with bilateral pelvic lymph node dissection. All cases were adenocarcinoma, including 20 mucinous adenocarcinoma, 7 moderately differentiated adenocarcinoma, 5 poorly differentiated adenocarcinoma, 1 signet ring cell carcinoma, 3 hybrid adenocarcinoma. The Sheldon pathologic stage was stage Ⅱ in 11, Ⅲ in 16 and Ⅳa in 9 cases. All patients received medical oncological therapy. The median follow-up period was 27 months. The median overall survival was 36 months. One-year survival rate was 70% and five-year survival rate was 28%.
  
  
  CONCLUSIONS
  Urachal carcinomas are rare and usually at locally advanced stage at diagnosis with a high tendency of metastases. Surgery is a key method of primary treatment and medical oncological therapy may play a role in decreasing the chances of recurrence which still needs to be explained by prospective clinical trials.
authors.affiliation: Department of Medical Oncology, Cancer Hospital of Chinese Academy of Medical Sciences, Beijing 100021, China.
authors.forename: H T
authors.initials: HT
authors.lastname: Niu
authors.affiliation: Department of Oncology, Cancer Hospital of Zibo Wanjie Shangdong, Zibo 255000, China.
authors.forename: P
authors.initials: P
authors.lastname: Dong
authors.forename: J N
authors.initials: JN
authors.lastname: Wang
authors.forename: J
authors.initials: J
authors.lastname: Huang
authors.forename: Y X
authors.initials: YX
authors.lastname: Zeng
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D015653:Cystectomy; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011184:Postoperative Period; D011379:Prognosis; D011446:Prospective Studies; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery*