title: Sex Difference in the Association Between Brachial Pulse Pressure and Coronary Artery Disease: The Korean Women's Chest Pain Registry (KoROSE).
abstract: This study was performed to investigate the association between brachial pulse pressure (PP) and the presence/extent of obstructive coronary artery disease (CAD) in men and women. Study data were obtained from a nation-wide registry composed of 632 patients (173 men and 459 women, 58.1±10.5 years) with suspected CAD who underwent invasive coronary angiography. PP was higher in patients with obstructive CAD (≥50% stenosis) than those without CAD in both sexes (P=.032 in men; P<.001 in women). However, PP increased proportionally with the increasing number of obstructed coronary arteries in women (P<.001) but not in men (P=.070). Multiple logistic-regression analyses demonstrated that higher PP (≥50.5 mm Hg) was an independent factor for determining obstructive CAD even after controlling for potential confounders in women (odds ratio, 2.83; 95% confidence interval, 1.40-5.73; P=.004). These results were consistent in 173 selected women matched with 173 men based on age and CAD severity. In conclusion, the association between brachial PP and obstructive CAD was more pronounced in women than in men. Brachial PP can be a simple and useful indicator of CAD especially in women.
authors.affiliation: Seoul National University Boramae Medical Center, Seoul, Korea.
authors.forename: Hack-Lyoung
authors.initials: HL
authors.lastname: Kim
authors.affiliation: Seoul National University Boramae Medical Center, Seoul, Korea.
authors.forename: Myung-A
authors.initials: MA
authors.lastname: Kim
authors.affiliation: Korea University Anam Hospital, Seoul, Korea.
authors.forename: Wan-Joo
authors.initials: WJ
authors.lastname: Shim
authors.affiliation: Seoul National University Boramae Medical Center, Seoul, Korea.
authors.forename: Sohee
authors.initials: S
authors.lastname: Oh
authors.affiliation: Korea University Anam Hospital, Seoul, Korea.
authors.forename: Mina
authors.initials: M
authors.lastname: Kim
authors.affiliation: Korea University Anam Hospital, Seoul, Korea.
authors.forename: Seong Mi
authors.initials: SM
authors.lastname: Park
authors.affiliation: Korea University Anam Hospital, Seoul, Korea.
authors.forename: Yong Hyun
authors.initials: YH
authors.lastname: Kim
authors.affiliation: Korea University Anam Hospital, Seoul, Korea.
authors.forename: Jin Oh
authors.initials: JO
authors.lastname: Na
authors.affiliation: Gachon Medical School Gil Medical Center, Incheon, Korea.
authors.forename: Mi Seung
authors.initials: MS
authors.lastname: Shin
authors.affiliation: Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Hyun Ju
authors.initials: HJ
authors.lastname: Yoon
authors.affiliation: Ewha Womans University Hospital, Seoul, Korea.
authors.forename: Gil Ja
authors.initials: GJ
authors.lastname: Shin
authors.affiliation: Kangnam CHA Hospital, Seoul, Korea.
authors.forename: Yunkyung
authors.initials: Y
authors.lastname: Cho
authors.affiliation: Hanllym University Chuncheon Sacred Heart Hospital, Chuncheon, Korea.
authors.forename: Sung-Eun
authors.initials: SE
authors.lastname: Kim
authors.affiliation: Hanllym University Chuncheon Sacred Heart Hospital, Chuncheon, Korea.
authors.forename: Kyung-Soon
authors.initials: KS
authors.lastname: Hong
authors.affiliation: Kosin University Gospel Hospital, Pusan, Korea.
authors.forename: Kyoung Im
authors.initials: KI
authors.lastname: Cho
mesh_terms: D000368:Aged; D001794:Blood Pressure; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012727:Sex Characteristics