title: A comparison of incidences of bladder neck contracture of 80- versus 180-W GreenLight laser photoselective vaporization of benign prostatic hyperplasia.
abstract: Bladder neck contracture (BNC) after GreenLight laser photoselective vaporization (PVP) of benign prostatic hyperplasia is a common complication. In the present study, data of patients received 80 or 180 W PVP were collected. Perioperative parameters, including applied energy, irradiation time, catheter removal time, and hospital stay, were recorded. Postoperative parameters, including maximum urinary flow rate, International Prostate Symptom Score, post-void residual volume, and incidences of BNC, were recorded at 3 and 12 months after operations. Bladder neck tissues were taken at 3 months after operations for immunohistochemical staining and western blot analysis to examine the expressions of collagen I, matrix metalloproteinase-3 (MMP-3), and transforming growth factor-β (TGF-β). Sample size of patients was calculated with a power of 80 %. Chi-square test and one-way analysis of variance were performed as statistical methods. Three hundred twenty-six patients who received potassium titanyl phosphate (KTP) laser and 256 who received X-ray photoelectron spectroscopy (XPS) laser entered into the study. Perioperative parameters were comparable, except for shorter irradiation time in 180 W group (P = 0.032). Postoperative parameters were also similar, except for higher incidence of BNC in 80 W group at 3 months after operations (P = 0.022). Immunohistochemical staining and western blot analysis showed higher expressions of collagen I, MMP-3, and TGF-β in 80 W group than in 180 W group. In conclusion, 80 W GreenLight laser showed a comparable efficacy with 180-W laser in PVP but showed a higher incidence of BNC in short term, which might be the result of up-regulated fibrotic factors in bladder neck triggered by lasers.
authors.affiliation: Minimally Invasive Urology Center, Shandong Provincial Hospital affiliated to Shandong University, 324 Jing5 Wei7 Road, Jinan, 250021, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Hu
authors.affiliation: Minimally Invasive Urology Center, Shandong Provincial Hospital affiliated to Shandong University, 324 Jing5 Wei7 Road, Jinan, 250021, China.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Song
authors.affiliation: Cystoscope Center, Shandong Provincial Hospital affiliated to Shandong University, Jinan, 250021, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Urology, Weifang People's Hospital, Weifang Medical College, Weifang, 261599, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Qiao
authors.affiliation: Minimally Invasive Urology Center, Shandong Provincial Hospital affiliated to Shandong University, 324 Jing5 Wei7 Road, Jinan, 250021, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Minimally Invasive Urology Center, Shandong Provincial Hospital affiliated to Shandong University, 324 Jing5 Wei7 Road, Jinan, 250021, China.
authors.forename: Muwen
authors.initials: M
authors.lastname: Wang
authors.affiliation: Minimally Invasive Urology Center, Shandong Provincial Hospital affiliated to Shandong University, 324 Jing5 Wei7 Road, Jinan, 250021, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Song
authors.affiliation: Minimally Invasive Urology Center, Shandong Provincial Hospital affiliated to Shandong University, 324 Jing5 Wei7 Road, Jinan, 250021, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Minimally Invasive Urology Center, Shandong Provincial Hospital affiliated to Shandong University, 324 Jing5 Wei7 Road, Jinan, 250021, China.
authors.forename: Xunbo
authors.initials: X
authors.lastname: Jin
authors.affiliation: Minimally Invasive Urology Center, Shandong Provincial Hospital affiliated to Shandong University, 324 Jing5 Wei7 Road, Jinan, 250021, China. zhy.sdu@hotmail.com.|Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA, 94143, USA. zhy.sdu@hotmail.com.
authors.forename: Haiyang
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003286:Contracture / Q000453:epidemiology* / Q000473:pathology; D006801:Humans; D015994:Incidence; D053685:Laser Therapy / Q000009:adverse effects*; D053844:Lasers, Solid-State / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D056951:Photoelectron Spectroscopy; D011183:Postoperative Complications / Q000453:epidemiology* / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000601:surgery*; D012189:Retrospective Studies; D016896:Treatment Outcome; D001743:Urinary Bladder / Q000473:pathology*
keywords: Benign prostatic hyperplasia; Bladder neck contracture; GreenLight laser; Photoselective vaporization of prostate; Transurethral resection of prostate