title: Esophageal replacement in children: Challenges and long-term outcomes.
abstract: Replacement of a nonexistent or damaged esophagus continues to pose a significant challenge to pediatric surgeons. Various esophageal replacement grafts and techniques have not produced consistently good outcomes to emulate normal esophagus. Therefore, many techniques are still being practiced and recommended with no clear consensus. We present a concise literature review of the currently used techniques and with discussions on the advantages and anticipated morbidity. There are no randomized controlled pediatric studies to compare different types of esophageal replacements. Management and graft choice are based on geographical and personal predilections rather than on any discernible objective data. The biggest series with long-term outcome are reported for gastric transposition and colonic replacement. Comparison of different studies shows no significant difference in early (graft necrosis and anastomotic leaks) or late complications (strictures, poor feeding, gastro-esophageal reflux, tortuosity of the graft, and Barrett's esophagus). The biggest series seem to have lower complications than small series reflecting the decennials experience in their respective centers. Long-term follow-up is recommended following esophageal replacement for the development of late strictures, excessive tortuosity, and Barrett's changes within the graft. Once child overcomes initial morbidity and establishes oral feeding, long-term consequences and complications of pediatric esophageal replacement should be monitored and managed in adult life.
authors.affiliation: Department of Paediatric Surgery, Birmingham Children's Hospital NHS Foundation Trust, Birmingham, UK.
authors.forename: Giampiero
authors.initials: G
authors.lastname: Soccorso
authors.affiliation: Department of Paediatric Surgery, Birmingham Children's Hospital NHS Foundation Trust, Birmingham, UK.
authors.forename: Dakshesh H
authors.initials: DH
authors.lastname: Parikh
keywords: Caustics; esophageal atresia; esophageal replacement; esophagus