title: Simple Synthesis of Both Enantiomers of the C7-C12 Segment of Epothilones.
abstract: Both enantiomers of the C7-C12 segment (3 and 4) of antitumor antibiotics epothilones (1and 2) were synthesized from methyl (R)- and (S)-3-hydroxy-2-methylpropionate (5 and 6) in five steps in a fair yield.
authors.affiliation: a Department of Applied Biochemistry, College of Agriculture, Osaka Prefecture University.
authors.forename: S
authors.initials: S
authors.lastname: Tanimori
authors.affiliation: a Department of Applied Biochemistry, College of Agriculture, Osaka Prefecture University.
authors.forename: K
authors.initials: K
authors.lastname: Tanimoto
authors.affiliation: a Department of Applied Biochemistry, College of Agriculture, Osaka Prefecture University.
authors.forename: M
authors.initials: M
authors.lastname: Kirihata
keywords: Grignard cross-coupling; antitumor antibiotics; epothilone; segment synthesis