title: Systems biology and the quest for correlates of protection to guide the development of an HIV vaccine.
abstract: Over the last three decades, a myriad of data has been generated regarding HIV/SIV evolution, immune evasion, immune response, and pathogenesis. Much of this data can be integrated and potentially used to generate a successful vaccine. Although individual approaches have begun to shed light on mechanisms involved in vaccine-conferred protection from infection, true correlates of protection have not yet been identified. The systems biology approach helps unify datasets generated using different techniques and broaden our understanding of HIV immunopathogenesis. Moreover, systems biology is a tool that can provide correlates of protection, which can be targeted for the production of a successful HIV vaccine.
authors.affiliation: Department of Pathology, Case Western Reserve University, Wolstein Research Building, 2103 Cornell Road, Cleveland, OH 44106, USA.
authors.forename: Leticia
authors.initials: L
authors.lastname: Kuri-Cervantes
authors.affiliation: Department of Pathology, Case Western Reserve University, Wolstein Research Building, 2103 Cornell Road, Cleveland, OH 44106, USA.
authors.forename: Slim
authors.initials: S
authors.lastname: Fourati
authors.affiliation: Department of Pathology, Case Western Reserve University, Wolstein Research Building, 2103 Cornell Road, Cleveland, OH 44106, USA.
authors.forename: Glenda
authors.initials: G
authors.lastname: Canderan
authors.affiliation: Department of Pathology, Case Western Reserve University, Wolstein Research Building, 2103 Cornell Road, Cleveland, OH 44106, USA. Electronic address: rafick.sekaly@case.edu.
authors.forename: Rafick-Pierre
authors.initials: RP
authors.lastname: Sekaly
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology*; D000818:Animals; D015658:HIV Infections / Q000276:immunology* / Q000517:prevention & control* / Q000821:virology; D015497:HIV-1 / Q000276:immunology* / Q000472:pathogenicity; D006801:Humans; D049490:Systems Biology
chemical_list: D016915:AIDS Vaccines