title: Clinical Problem Solving Series.
authors.affiliation: a Department of Medicine Tufts University School of Medicine Boston , U.S.A.
authors.forename: J P
authors.initials: JP
authors.lastname: Kassirer
authors.affiliation: a Department of Medicine Tufts University School of Medicine Boston , U.S.A.
authors.forename: R I
authors.initials: RI
authors.lastname: Kopelman