title: Expression of Bax Protein and Morphological Changes in the Myocardium in Experimental Acute Pressure Overload of the Left Ventricle.
abstract: The expression of Bax protein, marker of intracellular pathway of apoptosis initiation, in viable left ventricular cardiomyocytes and morphological changes in the myocardium in acute pressure overload of the left ventricle were studied in experiment on male rabbits. The content of Bax protein in the cardiomyocyte cytoplasm decreased, this indicating that the mitochondrial pathway was not involved in the realization of the apoptotic program. This decrease was associated with manifest destructive changes in the left ventricular myocardium.
authors.affiliation: Department of Pathology and Pathological Physiology, Moscow, Russia.
authors.forename: M L
authors.initials: ML
authors.lastname: Blagonravov
authors.affiliation: Department of Pathology and Pathological Physiology, Moscow, Russia.
authors.forename: A Yu
authors.initials: AY
authors.lastname: Korshunova
authors.affiliation: Department of Biology and Common Genetics, Medical Institute, Russian, University of Peoples' Friendship, Moscow, Russia. blagonravovm@mail.ru.
authors.forename: M M
authors.initials: MM
authors.lastname: Azova
authors.affiliation: Department of Pathology and Pathological Physiology, Moscow, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Bryk
authors.affiliation: Department of Pathology and Pathological Physiology, Moscow, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Frolov
mesh_terms: D000818:Animals; D006352:Heart Ventricles / Q000378:metabolism / Q000473:pathology; D008297:Male; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D032383:Myocytes, Cardiac / Q000378:metabolism*; D011817:Rabbits; D017725:Ventricular Pressure; D051028:bcl-2-Associated X Protein / Q000378:metabolism*
chemical_list: D051028:bcl-2-Associated X Protein
keywords: Bax; acute left ventricular overload; apoptosis; cardiomyocyte; myocardium