title: In Vitro Intestinal Permeability Studies and Pharmacokinetic Evaluation of Famotidine Microemulsion for Oral Delivery.
abstract: The absolute bioavailability of famotidine after oral administration is about 40-45% and absorbance only in the initial part of small intestine may be due to low intestinal permeability. Hence, an olive oil based microemulsion formulation with Tween-80 as surfactant and PEG-400 as cosurfactant was developed by using water titration method with the aim of enhancing the intestinal permeability as well as oral bioavailability. In vitro drug permeation in intestine after 8 h for all formulations varied from 30.42% to 78.39% and most of the formulations showed enhanced permeation compared to pure drug (48.92%). Famotidine microemulsion exhibited the higher absorption and C max⁡ achieved from the optimized famotidine formulation (456.20 ng·h/ml) was higher than the standard (126.80 ng·h/mL). It was found that AUC0-24 h obtained from the optimized famotidine test formulation (3023.5 ng·h/mL) was significantly higher than the standard famotidine (1663.3 ng·h/mL). F-1 demonstrated a longer (6 h) T max⁡ compared with standard drug (2 h) and sustained the release of drug over 24 h. The bioavailability of F-1 formulation was about 1.8-fold higher than that of standard drug. This enhanced bioavailability of famotidine loaded in microemulsion system might be due to increased intestinal permeability.
authors.affiliation: Department of Pharmaceutics, Bengal College of Pharmaceutical Sciences & Research, BRB Sarani, Bidhannagar, Durgapur 713212, India.
authors.forename: Sajal Kumar
authors.initials: SK
authors.lastname: Jha
authors.affiliation: Department of Industrial Pharmacy, Acharya & B.M. Reddy College of Pharmacy, Soldevanahalli, Bangalore 560090, India.
authors.forename: Roopa
authors.initials: R
authors.lastname: Karki
authors.affiliation: Department of Industrial Pharmacy, Acharya & B.M. Reddy College of Pharmacy, Soldevanahalli, Bangalore 560090, India.
authors.forename: Venkatesh Dinnekere
authors.initials: VD
authors.lastname: Puttegowda
authors.affiliation: Nishka Scientific & Reference Laboratories, Hyderabad, India.
authors.forename: D
authors.initials: D
authors.lastname: Harinarayana