title: Metal-Free [2 + 2 + 2] Cycloaddition of Ynamides with Nitriles to Construct 2,4-Diaminopyridines.
abstract: We present a metal-free [2 + 2 + 2] cycloaddition of ynamides with nitriles that enables highly efficient access to 2,4-diaminopyridines. This catalytic protocol is more environmentally friendly and allows for a concomitant construction of C-C and C-N bonds between ynamides and nitriles, exhibiting excellent chemoselectivity, regioselectivity, and wide functional groups tolerance.
authors.affiliation: Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, School of Pharmaceutical Sciences, and College of Chemistry and Molecular Engineering, Zhengzhou University , Zhengzhou, Henan 450001, P. R. China.
authors.forename: Jingyi
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, School of Pharmaceutical Sciences, and College of Chemistry and Molecular Engineering, Zhengzhou University , Zhengzhou, Henan 450001, P. R. China.
authors.forename: Qingshuang
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, School of Pharmaceutical Sciences, and College of Chemistry and Molecular Engineering, Zhengzhou University , Zhengzhou, Henan 450001, P. R. China.
authors.forename: Biao
authors.initials: B
authors.lastname: Xia
authors.affiliation: Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, School of Pharmaceutical Sciences, and College of Chemistry and Molecular Engineering, Zhengzhou University , Zhengzhou, Henan 450001, P. R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wu
authors.affiliation: Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, School of Pharmaceutical Sciences, and College of Chemistry and Molecular Engineering, Zhengzhou University , Zhengzhou, Henan 450001, P. R. China.
authors.forename: Xiao-Na
authors.initials: XN
authors.lastname: Wang
authors.affiliation: Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, School of Pharmaceutical Sciences, and College of Chemistry and Molecular Engineering, Zhengzhou University , Zhengzhou, Henan 450001, P. R. China.
authors.forename: Junbiao
authors.initials: J
authors.lastname: Chang