title: Mesenchymal stem cells in regenerative rehabilitation.
abstract: [Purpose] Regenerative medicine and rehabilitation contribute in many ways to a specific plan of care based on a patient's medical status. The intrinsic self-renewing, multipotent, regenerative, and immunosuppressive properties of mesenchymal stem cells offer great promise in the treatment of numerous autoimmune, degenerative, and graft-versus-host diseases, as well as tissue injuries. As such, mesenchymal stem cells represent a therapeutic fortune in regenerative medicine. The aim of this review is to discuss possibilities, limitations, and future clinical applications of mesenchymal stem cells. [Subjects and Methods] The authors have identified and discussed clinically and scientifically relevant articles from PubMed that have met the inclusion criteria. [Results] Direct treatment of muscle injuries, stroke, damaged peripheral nerves, and cartilage with mesenchymal stem cells has been demonstrated to be effective, with synergies seen between cellular and physical therapies. Over the past few years, several researchers, including us, have shown that there are certain limitations in the use of mesenchymal stem cells. Aging and spontaneous malignant transformation of mesenchymal stem cells significantly affect the functionality of these cells. [Conclusion] Definitive conclusions cannot be made by these studies because limited numbers of patients were included. Studies clarifying these results are expected in the near future.
authors.affiliation: Department of Biomedical Sciences, State University of Novi Pazar, Serbia; Center for Physical Medicine and Rehabilitation, Clinical Center Kragujevac, Serbia; Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Serbia.
authors.forename: Jasmin
authors.initials: J
authors.lastname: Nurkovic
authors.affiliation: Department of Biomedical Sciences, State University of Novi Pazar, Serbia; General Hospital Novi Pazar, Serbia.
authors.forename: Zana
authors.initials: Z
authors.lastname: Dolicanin
authors.affiliation: Dental Center Jezero, Serbia.
authors.forename: Fahrudin
authors.initials: F
authors.lastname: Mustafic
authors.affiliation: Department of Biomedical Sciences, State University of Novi Pazar, Serbia.
authors.forename: Rifat
authors.initials: R
authors.lastname: Mujanovic
authors.affiliation: Department of Biomedical Sciences, State University of Novi Pazar, Serbia.
authors.forename: Mensur
authors.initials: M
authors.lastname: Memic
authors.affiliation: Center for Physical Medicine and Rehabilitation, Clinical Center Kragujevac, Serbia; Faculty of Medical Sciences, University of Kragujevac, Serbia.
authors.forename: Vesna
authors.initials: V
authors.lastname: Grbovic
authors.affiliation: Center for Physical Medicine and Rehabilitation, Clinical Center Kragujevac, Serbia; Faculty of Medical Sciences, University of Kragujevac, Serbia.
authors.forename: Aleksandra Jurisic
authors.initials: AJ
authors.lastname: Skevin
authors.affiliation: Faculty of Medical Sciences, University of Kragujevac, Serbia; General Hospital Novi Pazar, Serbia.
authors.forename: Selmina
authors.initials: S
authors.lastname: Nurkovic
keywords: Mesenchymal stem cells; Regenerative rehabilitation