title: Study of Natural Cytotoxicity Receptors in Patients with HIV/AIDS and Cancer: A Cross-Sectional Study.
abstract: The NCR receptors play a fundamental role in the cytotoxicity mediated by NK cells against tumor cells. In the current study, we investigated possible HIV/AIDS-related changes in the expression of the NCR receptors comparing healthy donors, HIV/AIDS patients, and HIV/AIDS patients with cancer (HIV/AIDSWC). The NCRs were quantified in NK cells (NK(dim) and NK(bright)) and T lymphocytes from peripheral blood samples by flow cytometry. We found a significant decrease in the frequency of NK cells expressing NKp46 in HIV/AIDS group (p = 0.0012). There was a decrease in the frequency of NK cells expressing NKp46 in the HIV/AIDSWC group; however, this was not statistically significant. We found a significant decrease in the frequency of NK cells expressing NKp30 in the HIV/AIDS group (p = 0.0144). There was a decrease in the frequency of NK cells expressing NKp30 and in the HIV/AIDSWC group, but this was not statistically significant. There were no changes in the distribution of NK cells and their subtypes in both groups.
authors.affiliation: School of Medical Sciences, Rio de Janeiro State University, Professor Manoel de Abreu Avenue 444, 20550-170 Rio de Janeiro, RJ, Brazil.
authors.forename: Orlando Nascimento
authors.initials: ON
authors.lastname: Terra Junior
authors.affiliation: School of Medical Sciences, Rio de Janeiro State University, Professor Manoel de Abreu Avenue 444, 20550-170 Rio de Janeiro, RJ, Brazil.
authors.forename: Gabriel de Carvalho
authors.initials: Gde C
authors.lastname: Maldonado
authors.affiliation: School of Medical Sciences, Rio de Janeiro State University, Professor Manoel de Abreu Avenue 444, 20550-170 Rio de Janeiro, RJ, Brazil.
authors.forename: Guilherme Rohem
authors.initials: GR
authors.lastname: Alfradique
authors.affiliation: School of Medical Sciences, Rio de Janeiro State University, Professor Manoel de Abreu Avenue 444, 20550-170 Rio de Janeiro, RJ, Brazil.
authors.forename: Vinicius da Cunha
authors.initials: Vda C
authors.lastname: Lisboa
authors.affiliation: School of Medical Sciences, Rio de Janeiro State University, Professor Manoel de Abreu Avenue 444, 20550-170 Rio de Janeiro, RJ, Brazil.
authors.forename: Adriano
authors.initials: A
authors.lastname: Arnóbio
authors.affiliation: School of Medical Sciences, Rio de Janeiro State University, Professor Manoel de Abreu Avenue 444, 20550-170 Rio de Janeiro, RJ, Brazil.
authors.forename: Dirce Bonfim
authors.initials: DB
authors.lastname: de Lima
authors.affiliation: School of Medical Sciences, Rio de Janeiro State University, Professor Manoel de Abreu Avenue 444, 20550-170 Rio de Janeiro, RJ, Brazil.
authors.forename: Hilda Rachel
authors.initials: HR
authors.lastname: Diamond
authors.affiliation: School of Medical Sciences, Rio de Janeiro State University, Professor Manoel de Abreu Avenue 444, 20550-170 Rio de Janeiro, RJ, Brazil.
authors.forename: Maria Helena Faria Ornellas
authors.initials: MH
authors.lastname: de Souza
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D055627:Natural Cytotoxicity Triggering Receptor 1 / Q000276:immunology*; D055628:Natural Cytotoxicity Triggering Receptor 3 / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology*; D055815:Young Adult
chemical_list: C112260:NCR1 protein, human; C431710:NCR3 protein, human; D055627:Natural Cytotoxicity Triggering Receptor 1; D055628:Natural Cytotoxicity Triggering Receptor 3