title: Case report: successful retreatment of hepatitis C genotype 1b infection with sofosbuvir + simeprevir in a patient with cirrhosis who had prior virologic relapse after treatment with daclatasvir and asunaprevir.
abstract: There is currently minimal clinical experience regarding retreatment options for patients failing direct-acting antiviral combination regimens. Here, we report the outcomes of a HCV genotype 1b-infected patient with virologic failure following treatment with daclatasvir and asunaprevir, who was successfully retreated with sofosbuvir plus simeprevir.
authors.affiliation: Division of Medicine Institute of Gastroenterology and Liver Diseases Hadassah Medical Organization Hadassah Hebrew University Medical Center Jerusalem Israel; The Liver Unit Institute of Gastroenterology and Liver Diseases Division of Medicine Hadassah Medical Organization Hadassah Hebrew University Medical Center Jerusalem Israel.
authors.forename: Rifaat
authors.initials: R
authors.lastname: Safadi
authors.affiliation: Bristol-Myers Squibb Research and Development Princeton New Jersey.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Noviello
authors.affiliation: Bristol-Myers Squibb Research and Development Princeton New Jersey.
authors.forename: Navdeep
authors.initials: N
authors.lastname: Boparai
authors.affiliation: Bristol-Myers Squibb Research and Development Wallingford Connecticut.
authors.forename: Fiona
authors.initials: F
authors.lastname: McPhee
keywords: Asunaprevir; HCV; daclatasvir; retreatment