title: Roles of long noncoding RNAs in hepatocellular carcinoma.
abstract: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide with high prevalence and lethality. Hepatitis B virus (HBV) and Hepatitis C virus (HCV) infection are the major risk factors for HCC. Long noncoding RNAs (lncRNAs) are involved in diverse biological processes, and aberrant lncRNA expression is relevant to many human diseases including HCC. Although many researches on HCC have been reported and lncRNAs roles in carcinogenesis have been highlighted recently, reports on roles of lncRNAs in HBV/HCV-induced HCC are limited. In this review, we concentrate on recent progress regarding the functional roles of lncRNAs in HCC and HBV/HCV-related HCC.
authors.affiliation: Department of Blood Transfusion, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan Province 410008, China.
authors.forename: Linxi
authors.initials: L
authors.lastname: Shi
authors.affiliation: Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Peng
authors.affiliation: Cancer Research Institute, Central South University, 87 Xiangya Road, Changsha, Hunan 410078, China.
authors.forename: Yongguang
authors.initials: Y
authors.lastname: Tao
authors.affiliation: Hunan Key Laboratory of Viral Hepatitis,Xiangya Hospital, Central South University, Hunan Province, 87 Xiangya Road, Changsha 410008, China. Electronic address: xgfan@hotmail.com.
authors.forename: Xuegong
authors.initials: X
authors.lastname: Fan
authors.affiliation: Department of Blood Transfusion, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan Province 410008, China. Electronic address: nxli@hotmail.com.
authors.forename: Ning
authors.initials: N
authors.lastname: Li
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000209:etiology*; D015972:Gene Expression Regulation, Neoplastic; D016174:Hepacivirus / Q000235:genetics; D006509:Hepatitis B / Q000150:complications / Q000821:virology; D006515:Hepatitis B virus / Q000235:genetics; D006526:Hepatitis C / Q000150:complications / Q000821:virology; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology*; D062085:RNA, Long Noncoding / Q000235:genetics*
chemical_list: D062085:RNA, Long Noncoding
keywords: Hepatitis B virus; Hepatitis C virus; Hepatocellular carcinoma; Long noncoding RNAs