title: Morphogenetics in brown, beige and white fat development.
abstract: Brown and beige (or brite) fat cells are capable of evoking non-shivering thermogenesis in response to cold and β-adrenergic stimulation. By metabolizing lipids and carbohydrate via uncoupled respiration these cells directly convert energy to heat. The discovery of brown and brown-like adipocytes in adult humans has reinvigorated interest in stimulating brown and beige fat development to combat the obesity epidemic. This review focuses on the role that cytoskeleton dynamics play in the regulation of adipocyte biology, specifically beige and brown fat development and how newly discovered adipogenic morphogens affect these processes.
authors.affiliation: Department of Biochemistry, Boston University School of Medicine , Boston, MA.
authors.forename: Jean Z
authors.initials: JZ
authors.lastname: Lin
authors.affiliation: Department of Biochemistry, Boston University School of Medicine , Boston, MA.
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Farmer
keywords: beige fat; brown fat; cell shape; cytoskeleton dynamics; morphogens