title: Extracranial Venous Drainage Pattern in Multiple Sclerosis and Healthy Controls: Application of the 2011 Diagnostic Criteria for Chronic Cerebrospinal Venous Insufficiency.
abstract: The etiology of multiple sclerosis (MS) is still largely unknown and it has been proposed that an impaired venous drainage from the central nervous system, defined as chronic cerebrospinal venous insufficiency (CCSVI), may play a role in this. We investigated the prevalence of extracranial venous drainage pattern alterations in a cohort of MS patients based on the 2011 revised diagnostic criteria for CCSVI. Thirty-nine MS patients and 18 healthy subjects underwent blinded extra-cranial venous echo-color Doppler sonography to reveal the presence of CCSVI. There was no statistically significant difference between MS patients and healthy controls regarding CCSVI prevalence (p value = 0.53). The results challenge the hypothesis that CCSVI plays a primary role in the pathogenesis of MS.
authors.affiliation: Clinica Neurologica, Universitx00E0; degli Studi di Perugia, Perugia, Italy.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Cardaioli
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Di Filippo
authors.forename: Alessia
authors.initials: A
authors.lastname: Bianchi
authors.forename: Paolo
authors.initials: P
authors.lastname: Eusebi
authors.forename: Maria
authors.initials: M
authors.lastname: Di Gregorio
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Gaetani
authors.forename: Antongiulio
authors.initials: A
authors.lastname: Gallina
authors.forename: Paolo
authors.initials: P
authors.lastname: Calabresi
authors.forename: Paola
authors.initials: P
authors.lastname: Sarchielli
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000000981:diagnostic imaging / Q000209:etiology*; D015995:Prevalence; D017585:Ultrasonography, Doppler, Transcranial; D014689:Venous Insufficiency / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000453:epidemiology