title: Neurotropic Gamma-Delta T-Cell Lymphoma With CD30-Positive Lymphoid Infiltrates.
abstract: Primary cutaneous gamma-delta T-cell lymphoma (PCGD-TCL) is a clonal proliferation of gamma-delta T cells with a cytotoxic phenotype that is typically characterized by an aggressive clinical course with ulcerative plaques or subcutaneous nodules. In this report, the authors describe a patient who developed an ulcerated tumor on the left upper extremity and painful papules and nodules on the right lower extremity. Interestingly, several of the papulonodules on the right lower extremity underwent spontaneous involution. A skin biopsy of the papulonodular lesion demonstrated a superficial and deep perivascular interstitial infiltrate with a population of pleomorphic enlarged CD30-positive T cells. These enlarged lymphocytes lacked expression of TCR beta, CD4, CD8, and the pan T-cell antigen CD7, but were positive for TCR gamma, supporting the diagnosis of PCGD-TCL. The patient rapidly developed pain and severe weakness in the left upper limb and MRI revealed extensive neurolymphomatosis of the left brachial plexus. The patient was treated with chemotherapy with complete remission achieved. Unfortunately, her response was transient and the patient relapsed and ultimately died due to her disease. In this article, the authors describe an extraordinary case of a CD30-positive PCGD-TCL to expand the histopathological spectrum of CD30-positive and gamma-delta-positive lymphoproliferative disorders.
authors.affiliation: Departments of *Pathology, and †Dermatology, Stanford Medicine, Stanford, CA.
authors.forename: Bryan
authors.initials: B
authors.lastname: Gammon
authors.forename: Benjamin R
authors.initials: BR
authors.lastname: Gammon
authors.forename: Youn H
authors.initials: YH
authors.lastname: Kim
authors.forename: Jinah
authors.initials: J
authors.lastname: Kim
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017730:Ki-1 Antigen / Q000032:analysis / Q000096:biosynthesis*; D016410:Lymphoma, T-Cell, Cutaneous / Q000276:immunology / Q000473:pathology*; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000276:immunology / Q000473:pathology*; D016692:Receptors, Antigen, T-Cell, gamma-delta; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology
chemical_list: D014408:Biomarkers, Tumor; D017730:Ki-1 Antigen; D016692:Receptors, Antigen, T-Cell, gamma-delta