title: Effects of cortisol on the heart: characterization of myocardial involvement in cushing's disease by longitudinal cardiac MRI T1 mapping.
abstract: Cushing's disease (CD) is associated with alterations in cardiac geometry and function, shown to be reversible after treatment. Our aim was to study cortisol-related changes in myocardial content in CD at baseline and after treatment using MR myocardial T1 times.
  
  
  
  This is a longitudinal study performed in 10 patients with active CD matched with 10 hypertensive and 10 healthy controls. All subjects had MR after CD diagnosis and 6 months after cortisol normalization. The 1.5 Tesla MR protocol included left ventricular geometry and function assessment and MOLLI sequences before and after contrast injection as well as late gadolinium enhancement.
  
  
  
  At baseline, native myocardial T1 was significantly higher in CD patients compared with controls and the hypertensive group (1056 ± 139 ms versus 929 ± 80 ms, P = 0.023; 1056 ± 139 ms versus 952 ± 51, P = 0.049). After treatment, native and postcontrast myocardial T1 decreased in CD patients versus controls (1056 ± 139 ms versus 832 ± 78, P = 0.006 and 483 ± 69 ms versus 395 ± 39 ms, P = 0.010) reaching values even lower than found in controls (P = 0.038 and P = 0.001, respectively).
  
  
  
  Native myocardial T1 is increased in Cushing's disease independently from hypertension and notably decreases after effective treatment, highlighting its potential to detect subclinical diffuse myocardial involvement in this condition.
  
  
  
  2 J. Magn. Reson. Imaging 2017;45:147-156.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM) UMR 7371, UMR_S 1146, Laboratoire d'Imagerie Biomédicale, ICAN Imaging Core Lab, Paris, France.|Sorbonne Universités, UPMC Univ Paris 06, Faculté de Médecine, Paris, France.
authors.forename: Charles
authors.initials: C
authors.lastname: Roux
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM) UMR 7371, UMR_S 1146, Laboratoire d'Imagerie Biomédicale, ICAN Imaging Core Lab, Paris, France.|Sorbonne Universités, UPMC Univ Paris 06, Faculté de Médecine, Paris, France.|Institute of Cardiometabolism and Nutrition, ICAN, Paris, France.
authors.forename: Nadjia
authors.initials: N
authors.lastname: Kachenoura
authors.affiliation: Faculté de médecine et de pharmacie de Tanger, Maroc.
authors.forename: Zainab
authors.initials: Z
authors.lastname: Raissuni
authors.affiliation: Université Paris Descartes, INSERM UMR 970, Paris, France.|Assistance Publique-Hôpitaux de Paris, Hôpital Européen George Pompidou, Service de Radiologie Cardiovasculaire, Paris, France.
authors.forename: Elie
authors.initials: E
authors.lastname: Mousseaux
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM) U693, F-94276, Le Kremlin Bicêtre, France.|Assistance Publique-Hôpitaux de Paris, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, F-94276, Le Kremlin Bicêtre, France.|Université Paris-Sud, Faculté de Médecine Paris-Sud, UMR-S 693, F-94276, Le Kremlin Bicêtre, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Young
authors.affiliation: Radiology, Cambridge University Hospitals NHS Foundation Trust, UK.
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Graves
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, Faculté de Médecine, Paris, France.|Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, service d'endocrinologie, IE3M, Paris, France.
authors.forename: Christel
authors.initials: C
authors.lastname: Jublanc
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM) UMR 7371, UMR_S 1146, Laboratoire d'Imagerie Biomédicale, ICAN Imaging Core Lab, Paris, France.|Sorbonne Universités, UPMC Univ Paris 06, Faculté de Médecine, Paris, France.|Institute of Cardiometabolism and Nutrition, ICAN, Paris, France.|Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Département d'Imagerie Cardiovasculaire, Paris, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Cluzel
authors.affiliation: Assistance Publique-Hôpitaux de Paris, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, F-94276, Le Kremlin Bicêtre, France.|Université Paris-Sud, Faculté de Médecine Paris-Sud, UMR-S 693, F-94276, Le Kremlin Bicêtre, France.|Radiology, Cambridge University Hospitals NHS Foundation Trust, UK.
authors.forename: Philippe
authors.initials: P
authors.lastname: Chanson
authors.affiliation: Assistance Publique-Hôpitaux de Paris, Hôpital de Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, F-94276, Le Kremlin Bicêtre, France.|Université Paris-Sud, Faculté de Médecine Paris-Sud, UMR-S 693, F-94276, Le Kremlin Bicêtre, France.|Radiology, Cambridge University Hospitals NHS Foundation Trust, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: Kamenický
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM) UMR 7371, UMR_S 1146, Laboratoire d'Imagerie Biomédicale, ICAN Imaging Core Lab, Paris, France.|Sorbonne Universités, UPMC Univ Paris 06, Faculté de Médecine, Paris, France.|Institute of Cardiometabolism and Nutrition, ICAN, Paris, France.|Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Département d'Imagerie Cardiovasculaire, Paris, France.
authors.forename: Alban
authors.initials: A
authors.lastname: Redheuil
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D008875:Middle Aged; D047748:Pituitary ACTH Hypersecretion / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D018487:Ventricular Dysfunction, Left / Q000097:blood* / Q000000981:diagnostic imaging* / Q000209:etiology; D055815:Young Adult
chemical_list: D015415:Biomarkers; D006854:Hydrocortisone
keywords: Cushing's disease; T1 mapping; cardiovascular magnetic resonance imaging; myocardial fibrosis; tissue characterization