title: Effects of Neuroendocrine CB1 Activity on Adult Leydig Cells.
abstract: Endocannabinoids control male reproduction acting at central and local level via cannabinoid receptors. The cannabinoid receptor CB1 has been characterized in the testis, in somatic and germ cells of mammalian and non-mammalian animal models, and its activity related to Leydig cell differentiation, steroidogenesis, spermiogenesis, sperm quality, and maturation. In this short review, we provide a summary of the insights concerning neuroendocrine CB1 activity in male reproduction focusing on adult Leydig cell ontogenesis and steroid biosynthesis.
authors.affiliation: Dipartimento di Medicina Sperimentale, Seconda Università di Napoli , Napoli , Italy.
authors.forename: Gilda
authors.initials: G
authors.lastname: Cobellis
authors.affiliation: Dipartimento di Scienze Motorie e del Benessere, Università di Napoli Parthenope , Napoli , Italy.
authors.forename: Rosaria
authors.initials: R
authors.lastname: Meccariello
authors.affiliation: Dipartimento di Medicina Sperimentale, Seconda Università di Napoli , Napoli , Italy.
authors.forename: Rosanna
authors.initials: R
authors.lastname: Chianese
authors.affiliation: Dipartimento di Medicina Sperimentale, Seconda Università di Napoli , Napoli , Italy.
authors.forename: Teresa
authors.initials: T
authors.lastname: Chioccarelli
authors.affiliation: Dipartimento di Medicina Sperimentale, Seconda Università di Napoli , Napoli , Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Fasano
authors.affiliation: Dipartimento di Medicina Sperimentale, Seconda Università di Napoli , Napoli , Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Pierantoni
keywords: CB1; Leydig cells; endocannabinoids; spermatogenesis; steroidogenesis; testis