title: Evaluation of the Cytotoxic Activity of Chiral (E)-13-Hydroxy-10-oxo-11-octadecenoic Acid and Its Lactone.
abstract: Both the S and R enantiomers of (E)-13-hydroxy-10-oxo-11-octadecenoic acid (1) and (E)-10-oxo-11-octadecen-13-olide (2) had similar IC50 values against P388 mouse leukemia cells; i.e. the stereochemistry of the asymmetric center of 1 and 2 had no influence on the cytotoxic activity. Bioassay results of various compounds related to 1 and 2 suggests that the 10-oxo and lactone moieties of 2 were important for enhancing the cytotoxicity.
authors.affiliation: a Research Laboratories II, Tamanoi Vinegar Co.Ltd.
authors.forename: Y
authors.initials: Y
authors.lastname: Hayashi
authors.affiliation: a Research Laboratories II, Tamanoi Vinegar Co.Ltd.
authors.forename: Y
authors.initials: Y
authors.lastname: Nishikawa
authors.affiliation: a Research Laboratories II, Tamanoi Vinegar Co.Ltd.
authors.forename: H
authors.initials: H
authors.lastname: Mori
authors.affiliation: b Faculty of Engineering, Miyazaki University.
authors.forename: Y
authors.initials: Y
authors.lastname: Matsushita
authors.affiliation: b Faculty of Engineering, Miyazaki University.
authors.forename: K
authors.initials: K
authors.lastname: Sugamoto
authors.affiliation: b Faculty of Engineering, Miyazaki University.
authors.forename: T
authors.initials: T
authors.lastname: Matsui
keywords: (E)-10-oxo-11-octadecen-13-olide; (E)-13-hydroxy-10-oxo-11-octadecenoic acid; corn; cytotoxic activity; fatty acid