title: Advanced research on the microRNA mechanism in heart failure.
abstract: Heart failure is the end stage of most cardiac diseases and also an important cardiovascular disease. Ventricular remodeling, a complicated pathophysiological process involving multiple molecular pathways, is a crucial mechanism for the occurrence and development of heart failure. A microRNA (miRNA) is a highly conservative noncoding molecule containing 18-25 nucleotides. miRNA is different from other RNAs. It mainly serves as an endogenous gene-regulating factor, and is a member of the complex regulatory network. It induces gene repression of target transcripts by affecting mRNA at the post-transcriptional level Vasudevan et al. (2007) . This study aimed at determining the mechanism of miRNA action in heart failure.
authors.affiliation: Daping Hospital, Research Institute of Surgery, Third Military Medical University, No.10 Changjiang Zhilu, Daping, Yuzhong District, Chongqing 400042, China.
authors.forename: Jianying
authors.initials: J
authors.lastname: Deng
authors.affiliation: Daping Hospital, Research Institute of Surgery, Third Military Medical University, No.10 Changjiang Zhilu, Daping, Yuzhong District, Chongqing 400042, China. Electronic address: zhongqianjin@qq.com.
authors.forename: Qianjin
authors.initials: Q
authors.lastname: Zhong
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000639:trends*; D015316:Genetic Therapy / Q000639:trends; D006333:Heart Failure / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000627:therapeutic use; D009206:Myocardium / Q000473:pathology; D032383:Myocytes, Cardiac / Q000473:pathology / Q000502:physiology
chemical_list: D035683:MicroRNAs
keywords: Heart failure; Mechanism; MicroRNA