title: Differences in Monoamine Oxidase Activity in the Brain of Wistar and August Rats with High and Low Locomotor Activity: A Cytochemical Study.
abstract: Monoamine oxidase activity was quantitatively assessed by cytochemical method in brain structures (layers III and V of the sensorimotor cortex, caudate nucleus, nucleus accumbens, hippocampal CA3 field) of rats of August line and Wistar population with high and low locomotor activity in the open fi eld test. Monoamine oxidase activity (substrate tryptamine) predominated in the nucleus accumbens of Wistar rats with high motor activity in comparison with rats with low locomotor activity. In August rats, enzyme activity (substrates tryptamine and serotonin) predominated in the hippocampus of animals with high motor activity. Comparison of August rats with low locomotor activity and Wistar rats with high motor activity (i.e. animals demonstrating maximum differences in motor function) revealed significantly higher activity of the enzyme (substrates tryptamine and serotonin) in the hippocampus of Wistar rats. The study demonstrates clear-cut morphochemical specificity of monoaminergic metabolism based on the differences in the cytochemical parameter "monoamine oxidase activity", in the studied brain structures, responsible for the formation and realization of goal-directed behavior in Wistar and August rats.
authors.affiliation: Research Center of Neurology, Moscow, Russia. sergutina.anven@yandex.ru.
authors.forename: A V
authors.initials: AV
authors.lastname: Sergutina
authors.affiliation: Research Center of Neurology, Moscow, Russia.
authors.forename: V I
authors.initials: VI
authors.lastname: Rakhmanova
mesh_terms: D000818:Animals; D006624:Hippocampus / Q000201:enzymology; D008124:Locomotion; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D009714:Nucleus Accumbens / Q000201:enzymology; D011919:Rats, Inbred Strains; D017208:Rats, Wistar; D066191:Sensorimotor Cortex / Q000201:enzymology; D013315:Stress, Psychological / Q000201:enzymology
chemical_list: D008995:Monoamine Oxidase
keywords: Wistar and August rats; brain structures; cytochemistry of brain enzymes; locomotor activity of rats; monoamine oxidase