title: Safety and efficacy of daclatasvir in the management of patients with chronic hepatitis C.
abstract: Daclatasvir (Daklinza™), a new oral direct-acting antiviral, is an inhibitor of hepatitis C virus NS5A protein and has recently been approved in the United States, Europe and Japan in chronic hepatitis C. It shows potent pangenotypic activity and moderately high genetic barrier to resistance improving the sustained virological response (SVR) rates. In COMMAND phase 2 trials, daclatasvir demonstrated high SVR rates in HCV genotype 1-4 chronically infected patients treated with peginterferon-a (pegIFNα) plus ribavirin (RBV). Furthermore, it produced even higher response rates in all-oral combination with sofosbuvir, an interferon-free regimen, with or without ribavirin, in patients with advanced liver disease, HCV/HIV coinfection, liver transplantation in ALLY studies and other real-world studies. This narrative review provides information on the pharmacological properties, role, efficacy and safety of daclatasvir-containing regimens in chronic hepatitis C patients. Daclatasvir administered once-daily in combination with sofosbuvir is an effective 12-week treatment in adult patients with chronic hepatitis C and is generally safe and well tolerated.
authors.affiliation: 2 Department of Internal Medicine, Hippocration General Hospital, Athens Greece (Spilios Manolakopoulos).
authors.forename: Spilios
authors.initials: S
authors.lastname: Manolakopoulos
authors.affiliation: Endoscopy Unit, Limassol General Hospital and St George's University of London Medical School at the University of Nicosia, Republic of Cyprus (George Zacharakis); Department of Internal Medicine, University Hospital, Prince Sattam Bin Abdulaziz University, Al Kharj, KSA (George Zacharakis).
authors.forename: George
authors.initials: G
authors.lastname: Zacharakis
authors.affiliation: Medical Affairs Department, Bristol-Myers Squibb, Athens Greece (Miltiadis Zissis, Vassilis Giannakopoulos).
authors.forename: Miltiadis
authors.initials: M
authors.lastname: Zissis
authors.affiliation: Medical Affairs Department, Bristol-Myers Squibb, Athens Greece (Miltiadis Zissis, Vassilis Giannakopoulos).
authors.forename: Vassilis
authors.initials: V
authors.lastname: Giannakopoulos
keywords: Daclatasvir; chronic hepatitis C; treatment