title: Monosubstituted Benzene Derivatives from Fruits of Ficus hirta and Their Antifungal Activity against Phytopathogen Penicillium italicum.
abstract: Ficus hirta, a widely consumed food by Hakka people, has been reported to show potent antifungal activity against phytopathogen Penicillium italicum. However, there is no report of chemical constituents responsible for the antifungal activity. In the current study, nine monosubstituted benzene derivatives, including three new derivatives (1-3), were isolated from the fruits of F. hirta. The structures of these isolates were elucidated on the basis of the analysis of spectroscopic data (mass spectrometry and nuclear magnetic resonance). All of the isolates were evaluated for antifungal activities against P. italicum. At an equivalent concentration, compound 1 exhibited stronger antifungal activity than that of the ethanol extract of F. hirta fruits.
authors.affiliation: Jiangxi Key Laboratory for Postharvest Technology and Nondestructive Testing of Fruits & Vegetables, Collaborative Innovation Center of Post-harvest Key Technology and Quality Safety of Fruits and Vegetables in Jiangxi Province, Jiangxi Agricultural University , Nanchang, Jiangxi 330045, People's Republic of China.
authors.forename: Chunpeng
authors.initials: C
authors.lastname: Wan
authors.affiliation: Key Laboratory of Plant Resources and Chemistry of Arid Zone, Chinese Academy of Sciences, State Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Urumqi, Xinjiang 830011, People's Republic of China.
authors.forename: Jianxin
authors.initials: J
authors.lastname: Han
authors.affiliation: Jiangxi Key Laboratory for Postharvest Technology and Nondestructive Testing of Fruits & Vegetables, Collaborative Innovation Center of Post-harvest Key Technology and Quality Safety of Fruits and Vegetables in Jiangxi Province, Jiangxi Agricultural University , Nanchang, Jiangxi 330045, People's Republic of China.
authors.forename: Chuying
authors.initials: C
authors.lastname: Chen
authors.affiliation: Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine , Nanchang, Jiangxi 330006, People's Republic of China.
authors.forename: Liangliang
authors.initials: L
authors.lastname: Yao
authors.affiliation: Jiangxi Key Laboratory for Postharvest Technology and Nondestructive Testing of Fruits & Vegetables, Collaborative Innovation Center of Post-harvest Key Technology and Quality Safety of Fruits and Vegetables in Jiangxi Province, Jiangxi Agricultural University , Nanchang, Jiangxi 330045, People's Republic of China.
authors.forename: Jinyin
authors.initials: J
authors.lastname: Chen
authors.affiliation: Key Laboratory of Plant Resources and Chemistry of Arid Zone, Chinese Academy of Sciences, State Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Urumqi, Xinjiang 830011, People's Republic of China.
authors.forename: Tao
authors.initials: T
authors.lastname: Yuan
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D001555:Benzene Derivatives / Q000737:chemistry* / Q000494:pharmacology*; D030681:Ficus / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry; D010407:Penicillium / Q000187:drug effects* / Q000254:growth & development; D010935:Plant Diseases / Q000382:microbiology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D001555:Benzene Derivatives; D010936:Plant Extracts
keywords: Ficus hirta; Penicillium italicum; antifungal; monosubstituted benzene; phytopathogen