title: Influence of a 10-Day Mimic of Our Ancient Lifestyle on Anthropometrics and Parameters of Metabolism and Inflammation: The "Study of Origin".
abstract: Chronic low-grade inflammation and insulin resistance are intimately related entities that are common to most, if not all, chronic diseases of affluence. We hypothesized that a short-term intervention based on "ancient stress factors" may improve anthropometrics and clinical chemical indices. We executed a pilot study of whether a 10-day mimic of a hunter-gatherer lifestyle favorably affects anthropometrics and clinical chemical indices. Fifty-five apparently healthy subjects, in 5 groups, engaged in a 10-day trip through the Pyrenees. They walked 14 km/day on average, carrying an 8-kilo backpack. Raw food was provided and self-prepared and water was obtained from waterholes. They slept outside in sleeping bags and were exposed to temperatures ranging from 12 to 42°C. Anthropometric data and fasting blood samples were collected at baseline and the study end. We found important significant changes in most outcomes favoring better metabolic functioning and improved anthropometrics. Coping with "ancient mild stress factors," including physical exercise, thirst, hunger, and climate, may influence immune status and improve anthropometrics and metabolic indices in healthy subjects and possibly patients suffering from metabolic and immunological disorders.
authors.affiliation: Natura Foundation, 3281 NC Numansdorp, Netherlands; Laboratory Medicine, University Medical Center Groningen (UMCG) and University of Groningen, 9713 GZ Groningen, Netherlands.
authors.forename: Leo
authors.identifier: 0000-0003-2955-4675
authors.initials: L
authors.lastname: Pruimboom
authors.affiliation: Laboratory Medicine, University Medical Center Groningen (UMCG) and University of Groningen, 9713 GZ Groningen, Netherlands.
authors.forename: Begoña
authors.initials: B
authors.lastname: Ruiz-Núñez
authors.affiliation: Department of Psychiatry, College of Medicine, John and Doris Norton School of Family and Consumer Sciences, Tucson, AZ 1075, USA.
authors.forename: Charles L
authors.initials: CL
authors.lastname: Raison
authors.affiliation: Laboratory Medicine, University Medical Center Groningen (UMCG) and University of Groningen, 9713 GZ Groningen, Netherlands.
authors.forename: Frits A J
authors.initials: FA
authors.lastname: Muskiet
mesh_terms: D000222:Adaptation, Physiological / Q000276:immunology; D000328:Adult; D000368:Aged; D000886:Anthropometry / Q000379:methods; D001786:Blood Glucose / Q000276:immunology; D001835:Body Weight / Q000276:immunology*; D004734:Energy Metabolism / Q000276:immunology*; D015444:Exercise; D005260:Female; D015438:Health Behavior; D006801:Humans; D006815:Hunger; D007113:Immunity, Innate / Q000276:immunology; D007249:Inflammation / Q000276:immunology* / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D013312:Stress, Physiological / Q000276:immunology*; D055815:Young Adult
chemical_list: D001786:Blood Glucose