title: Synthesis and Fungicidal Activities of 4,5-Dihydro-7H-pyrano[3,4-c]isoxazole Derivatives.
abstract: 4,5-Dihydro-7H-pyrano[3,4-c]isoxazoles (II and III) with an o-chlorophenyl or p-chlorophenyl group at C-7 were synthesized and the effect of substitution at C-3 of II and III on fungicidal activity was investigated in vivo. When the substituent at C-3 of II and III was CH2Br, CH=NOMe, CH=NOEt or CH=NO-allyl, the fungicidal effect was significant and selectively high on wheat leaf rust and barley powdery mildew at 250 ppm. Compound IId with the CH2Br substituent at C-7 showed high fungicidal activity against rice blast, providing more than 90% control of the disease at 2 ppm.
authors.affiliation: a Department of Chemical Technology, Chonnam National University.
authors.forename: H J
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: a Department of Chemical Technology, Chonnam National University.
authors.forename: J Y
authors.initials: JY
authors.lastname: Jang
authors.affiliation: b Bio-Organic Division, Korea Research Institute of Chemical Technology.
authors.forename: K H
authors.initials: KH
authors.lastname: Chung
authors.affiliation: b Bio-Organic Division, Korea Research Institute of Chemical Technology.
authors.forename: J H
authors.initials: JH
authors.lastname: Lee
keywords: fungicidal activity; plant pathogen; pyrano[3,4-c]isoxazole; rice blast; wheat leaf rust