title: Gastroesophageal reflux disease: recent advances and its association with sleep.
abstract: Gastroesophageal reflux disease (GERD) is prevalent in Asia as well as in Western countries. Sleep disturbance and breathing disorders during sleep are becoming increasingly prevalent, and they are commonly associated with GERD. The relationship between GERD and obstructive sleep apnea (OSA) is still questionable, and it has expanded to include Barrett's esophagus. Nocturnal gastroesophageal reflux (nGER) symptoms might be clinically important in the explanation of this association. The therapy for reflux symptoms has resulted in improved subjective sleep parameters and enhanced sleep quality, thus supporting a direct relationship between GERD and sleep disturbance. This review discusses the epidemiology of sleep disturbances in GERD patients; the causative relationship between GERD and OSA, even though it remains an area of controversy; and the possible role of nGER in sleep problems. It also provides an update on the current state of knowledge linking GERD and sleep.
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, St. Paul's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. ojh@catholic.ac.kr.
authors.forename: Jung Hwan
authors.initials: JH
authors.lastname: Oh
mesh_terms: D016022:Case-Control Studies; D005764:Gastroesophageal Reflux / Q000453:epidemiology* / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D012307:Risk Factors; D012890:Sleep / Q000502:physiology*; D020181:Sleep Apnea, Obstructive / Q000453:epidemiology* / Q000503:physiopathology* / Q000628:therapy
keywords: Barrett's esophagus; gastroesophageal reflux; obstructive sleep apnea; sleep