title: Matrix metalloproteinase-9 Gene-1562C>T Gene Polymorphism and Coronary Artery Disease in the Chinese Han Population: A Meta-Analysis of 5468 Subjects.
abstract: BACKGROUND
  Multiple studies indicate that the matrix metalloproteinase-9 (MMP-9)-1562C>T gene polymorphism may be associated with an increased risk of coronary artery disease (CAD) in the Chinese Han population. However, a clear consensus has yet to be established.
  
  
  OBJECTIVE
  A meta-analysis of 5468 subjects from 10 separate studies was performed to explore the possible relationship between the MMP-9-1562C>T gene polymorphism and CAD within the Chinese Han population. Pooled odds ratio (ORs) for the association and the corresponding 95% confidence intervals (CIs) were evaluated by a random or fixed-effect model.
  
  
  RESULTS
  Our analysis confirms the association between the MMP-9-1562C>T gene polymorphism and an increased risk of CAD within the Chinese Han population under allelic (OR: 1.60, 95% CI: 1.25-2.04, P = 0.0002), recessive (OR: 3.05, 95% CI: 1.67-5.56, P = 0.0003), dominant (OR: 2.23, 95% CI: 1.49-3.35, P = 0.0001), homozygous (OR: 3.41, 95% CI: 1.87-6.23, P < 0.0001), heterozygous (OR: 2.03, 95% CI: 1.40-2.93, P = 0.0002), and additive genetic models (OR: 1.78, 95% CI: 1.33-2.39, P < 0.0001).
  
  
  CONCLUSIONS
  In the Chinese Han population, the MMP-9-1562C>T gene polymorphism is correlated with an increased risk of CAD. Therefore, Han Chinese carriers of the -1562T allele may be at an increased risk of CAD.
authors.affiliation: Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University Nanjing, China.
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Li
authors.affiliation: Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University Nanjing, China.
authors.forename: Xin-Xing
authors.initials: XX
authors.lastname: Yang
authors.affiliation: Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University Nanjing, China.
authors.forename: Yan-Hong
authors.initials: YH
authors.lastname: Zhou
authors.affiliation: Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University Nanjing, China.
authors.forename: Ge
authors.initials: G
authors.lastname: Gong
authors.affiliation: Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University Nanjing, China.
authors.forename: Hong-Yu
authors.initials: HY
authors.lastname: Geng
authors.affiliation: Department of Radiation Oncology, University of Pennsylvania Philadelphia, PA, USA.
authors.forename: Hyun J
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University Nanjing, China.
authors.forename: Chuan-Wei
authors.initials: CW
authors.lastname: Zhou
authors.affiliation: Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University Nanjing, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Qian
authors.affiliation: Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University Nanjing, China.
authors.forename: Xiang-Ming
authors.initials: XM
authors.lastname: Wang
authors.affiliation: Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University Nanjing, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wu
keywords: -1562C>T; Chinese; coronary artery disease; matrix metalloproteinase-9; polymorphism