title: Impact of HIV-1 infection on the feto-maternal crosstalk and consequences for pregnancy outcome and infant health.
abstract: Adaptation of the maternal immune system to establish maternal/fetal equilibrium is required for a successful pregnancy. Viral infections, including HIV-1 infection, can alter this maternal/fetal equilibrium, with significant consequences for pregnancy outcome, including miscarriages, impaired fetal growth, and premature delivery. Furthermore, maternal HIV-1 infection has been shown to have a long-term impact on the developing fetal immune system also when the infant is not infected with the virus. In this review, we discuss the consequences of maternal HIV-1 infection and antiretroviral therapy on pregnancy outcome and the health of the uninfected HIV-1-exposed infant.
authors.affiliation: Department of Virus Immunology, Heinrich-Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.
authors.forename: Marcus
authors.initials: M
authors.lastname: Altfeld
authors.affiliation: Department of Virus Immunology, Heinrich-Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany. m.j.bunders@amc.uva.nl.|Department of Experimental Immunology, University of Amsterdam (UvA), Academic Medical Center (AMC), Amsterdam, The Netherlands. m.j.bunders@amc.uva.nl.|Emma Childrens Hospital,UvA, AMC, Amsterdam, The Netherlands. m.j.bunders@amc.uva.nl.
authors.forename: Madeleine J
authors.initials: MJ
authors.lastname: Bunders
mesh_terms: D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects / Q000379:methods; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000276:immunology / Q000821:virology; D015497:HIV-1 / Q000276:immunology; D006801:Humans; D007107:Immune System / Q000166:cytology / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D056747:Immunomodulation / Q000187:drug effects; D007223:Infant; D000068104:Infant Health; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D018811:Maternal Exposure / Q000009:adverse effects; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D011256:Pregnancy Outcome; D047928:Premature Birth / Q000276:immunology; D011297:Prenatal Exposure Delayed Effects
keywords: HIV-1; Immune activation; Infant; MTCT; Pregnancy