title: Circulating cartilage oligomeric matrix protein in juvenile idiopathic arthritis.
abstract: OBJECTIVE
  Raised serum cartilage oligomeric matrix protein (sCOMP) has been reported to predict erosive disease in early rheumatoid arthritis (RA). In juvenile idiopathic arthritis (JIA), subnormal sCOMP levels have been associated with ongoing inflammation and growth retardation. In this study we aimed to assess sCOMP, C-reactive protein (CRP), and insulin-like growth factor (IGF)-1 in children/adolescents with JIA and in referents.
  
  
  METHODS
  We enrolled 52 JIA patients at planned outpatient visits and 54 inpatients with ongoing infection ('infection referents'). A total of 120 referents testing negative for immunoglobulin (Ig)E-mediated allergy ('IgE referents') served as controls. All serum samples were analysed for COMP, IGF-1, and CRP.
  
  
  RESULTS
  The average sCOMP level was highest among the IgE referents and lowest among the infection referents. In the JIA patients, the level of sCOMP was not associated with the level of CRP or with clinical signs of disease activity.
  
  
  CONCLUSIONS
  The results of this study do not support routine clinical analysis of sCOMP levels in patients with JIA.
authors.affiliation: a Division of Neuro and Inflammation Sciences, Department of Clinical and Experimental Medicine , Faculty of Medicine and Health Sciences, Linköping University , Linköping , Sweden.|b Department of Paediatrics , County Council of Östergötland , Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Lewander
authors.affiliation: a Division of Neuro and Inflammation Sciences, Department of Clinical and Experimental Medicine , Faculty of Medicine and Health Sciences, Linköping University , Linköping , Sweden.|c Department of Clinical Immunology and Transfusion Medicine , County Council of Östergötland , Linköping , Sweden.
authors.forename: C
authors.initials: C
authors.lastname: Dahle
authors.affiliation: d Clinical Chemistry Laboratory , County Council of Östergötland , Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Larsson
authors.affiliation: a Division of Neuro and Inflammation Sciences, Department of Clinical and Experimental Medicine , Faculty of Medicine and Health Sciences, Linköping University , Linköping , Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Wetterö
authors.affiliation: a Division of Neuro and Inflammation Sciences, Department of Clinical and Experimental Medicine , Faculty of Medicine and Health Sciences, Linköping University , Linköping , Sweden.|e Rheumatology clinic, Heart and Medicine Centre , County Council of Östergötland , Sweden.
authors.forename: T
authors.initials: T
authors.lastname: Skogh
mesh_terms: D000293:Adolescent; D001171:Arthritis, Juvenile / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism*; D064236:Cartilage Oligomeric Matrix Protein / Q000378:metabolism*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007223:Infant; D007239:Infections / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male
chemical_list: D002097:C-Reactive Protein; D064236:Cartilage Oligomeric Matrix Protein; D007334:Insulin-Like Growth Factor I; C583557:IGF1 protein, human; C577553:TSP5 protein, human