title: Dietary B Vitamins and Serum C-Reactive Protein in Persons With Human Immunodeficiency Virus Infection: The Positive Living With HIV (POLH) Study.
abstract: B vitamins may have beneficial roles in reducing inflammation; however, research on the role of B vitamins in inflammation among HIV-infected persons is lacking.
  
  
  
  This study assessed the association between B vitamins and serum C-reactive protein (CRP) concentrations in HIV-infected persons.
  
  
  
  A cross-sectional survey was conducted among 314 HIV-infected persons (180 men and 134 women) aged 18 to 60 years residing in the Kathmandu, Nepal. High-sensitive and regular serum CRP concentrations were measured by the latex agglutination nephelometry and latex agglutination turbidimetric method, respectively. Dietary intake was assessed using 2 nonconsecutive 24-hour dietary recalls. The relationships between B vitamins and serum CRP concentrations were assessed using multiple regression analysis.
  
  
  
  The multivariate-adjusted geometric mean of serum CRP concentrations was significantly decreased with an increasing B vitamins intake across quartiles of niacin (P for trend = .007), pyridoxine (P for trend = .042), and cobalamin (P for trend = .037) in men. In men, the mean serum CRP concentrations in the highest quartiles of niacin, pyridoxine, and cobalamin were 63%, 38%, and 58%, respectively, lower than that in the lowest quartile. In women, the mean serum CRP concentrations in the highest quartiles of riboflavin (P for trend = .084) and pyridoxine (P for trend = .093) were 37% and 47%, respectively, lower than that in the lowest quartile.
  
  
  
  High intake of niacin, pyridoxine, or cobalamin was independently associated with decreased serum CRP concentrations among HIV-infected men. Further prospective studies are warranted to confirm the role of B vitamins in inflammation among HIV-infected persons.
authors.affiliation: College of Nursing, University of Massachusetts Amherst, Amherst, MA, USA kalpana@nursing.umass.edu.
authors.forename: Kalpana
authors.initials: K
authors.lastname: Poudel-Tandukar
authors.affiliation: Centre for International Health, University of Bergen, Norway.|Department of Community Medicine, Kathmandu Medical College, Kathmandu, Nepal.
authors.forename: Ram Krishna
authors.initials: RK
authors.lastname: Chandyo
mesh_terms: D000293:Adolescent; D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis*; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000097:blood*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009390:Nepal; D014803:Vitamin B Complex / Q000097:blood*; D055815:Young Adult
chemical_list: D014803:Vitamin B Complex; D002097:C-Reactive Protein
keywords: B vitamins; C-reactive protein; HIV; developing country; dietary assessment