title: Noninvasive and high-resolving photoacoustic dermoscopy of human skin.
abstract: We proposed and developed a photoacoustic (PA) dermoscope equipped with an integrated PA probe to achieve quantification and high-resolution, high-contrast deep imaging of human skin. The PA probe, with light-sound confocal excitation and reception, is specially designed, and integrated with an objective lens, an ultrasound transducer, and an inverted-triangle coupling cup to facilitate convenient implementation in a clinical setting. The PA dermoscope was utilized for noninvasive and high-resolution imaging of epidermal and dermal structure in volunteers. The imaging results demonstrated that the characteristic parameters of skin disease, including pigment distribution and thickness, vascular diameter, and depth, can be obtained by the PA dermoscope, confirming that PA dermoscopy can serve as a potential tool for the diagnosis and curative effect evaluation of human skin disease.
authors.affiliation: MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Xu
authors.affiliation: MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China.
authors.forename: Sihua
authors.initials: S
authors.lastname: Yang
authors.affiliation: Department of Laser Medicine, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Laser Medicine, Chinese People's Liberation Army General Hospital, Beijing 100853, China; guyinglaser@sina.com.
authors.forename: Ying
authors.initials: Y
authors.lastname: Gu
authors.affiliation: MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China; xingda@scnu.edu.cn.
authors.forename: Da
authors.initials: D
authors.lastname: Xing
keywords: (170.0180) Microscopy; (170.3880) Medical and biological imaging; (170.5120) Photoacoustic imaging