title: Morinda citrifolia leaf enhanced performance by improving angiogenesis, mitochondrial biogenesis, antioxidant, anti-inflammatory & stress responses.
abstract: Morinda citrifolia fruit, (noni), enhanced performances in athletes and post-menopausal women in clinical studies. This report shows the edible noni leaves water extract enhances performance in a weight-loaded swimming animal model better than the fruit or standardized green tea extract. The 4weeks study showed the extract (containing scopoletin and epicatechin) progressively prolonged the time to exhaustion by threefold longer than the control, fruit or tea extract. The extract improved (i) the mammalian antioxidant responses (MDA, GSH and SOD2 levels), (ii) tissue nutrient (glucose) and metabolite (lactate) management, (iii) stress hormone (cortisol) regulation; (iv) neurotransmitter (dopamine, noradrenaline, serotonin) expressions, transporter or receptor levels, (v) anti-inflammatory (IL4 & IL10) responses; (v) skeletal muscle angiogenesis (VEGFA) and (v) energy and mitochondrial biogenesis (via PGC, UCP3, NRF2, AMPK, MAPK1, and CAMK4). The ergogenic extract helped delay fatigue by enhancing energy production, regulation and efficiency, which suggests benefits for physical activities and disease recovery.
authors.affiliation: UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
authors.forename: Nor Aijratul Asikin
authors.initials: NA
authors.lastname: Mohamad Shalan
authors.affiliation: Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
authors.forename: Noordin M
authors.initials: NM
authors.lastname: Mustapha
authors.affiliation: UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia. Electronic address: mohamed.suhaila@gmail.com.
authors.forename: Suhaila
authors.initials: S
authors.lastname: Mohamed
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000032:analysis* / Q000494:pharmacology / Q000627:therapeutic use; D000975:Antioxidants / Q000032:analysis* / Q000494:pharmacology / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D051379:Mice; D008813:Mice, Inbred ICR; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D032066:Morinda; D018919:Neovascularization, Physiologic / Q000187:drug effects* / Q000502:physiology; D001678:Organelle Biogenesis; D010936:Plant Extracts / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use; D018515:Plant Leaves; D013315:Stress, Psychological / Q000188:drug therapy* / Q000378:metabolism / Q000523:psychology
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D010936:Plant Extracts
keywords: Angiogenesis; Epicatechin; Exercise performance; Fatigue; Mitochondrial biogenesis; Morinda citrifolia leaves; Scopoletin