title: The Effect of Flurbiprofen on Postoperative Sore Throat and Hoarseness After LMA-ProSeal Insertion: A Randomised, Clinical Trial.
abstract: OBJECTIVE
  We hypothesized that flurbiprofen lozenges reduce the ProSeal laryngeal mask airway (LMA) related symptoms of Post Operative Sore Throat (POST), hoarseness and dysphagia compared to placebo lozenges.
  
  
  METHODS
  Eighty American Society of Anesthesiologists (ASA) I-II patients undergoing general anaesthesia with LMA were included in this prospective, randomized, placebo-controlled clinical and single centre (university hospital) study. Group F received an 8.75 mg flurbiprofen lozenge (Strefen(®)) and Group P received a placebo lozenge 45 minutes before the induction of anaesthesia. Postoperative sore throat, hoarseness and dysphagia were evaluated 30 minutes after removal of the LMA in the recovery room and then at 4, 12 and 24 h after surgery using a 4-point scale. Data were analysed using Student's t test, and Fisher's exact and Mann-Whitney U tests. A p value of <0.05 was considered statistically significant.
  
  
  RESULTS
  The 8.75 mg flurbiprofen lozenges reduced the severity of early (30 mins) POST and dysphagia. The severity of dysphagia at 4 h and hoarseness at 12 h were also significantly reduced in Group F. There were no significant differences betweeen the groups regarding incidence of sore throat, dysphagia and hoarseness throughout the study period.
  
  
  CONCLUSIONS
  Preoperative flurbiprofen lozenges reduce the severity of early postoperative sore throat and dysphagia.
authors.affiliation: Department of Anaesthesiology and Reanimation, Yeditepe University Faculty of Medicine, İstanbul, Turkey.
authors.forename: Neslihan
authors.initials: N
authors.lastname: Uztüre
authors.affiliation: Department of Anaesthesiology and Reanimation, Yeditepe University Faculty of Medicine, İstanbul, Turkey.
authors.forename: Ferdi
authors.initials: F
authors.lastname: Menda
authors.affiliation: Department of Anaesthesiology and Reanimation, Yeditepe University Faculty of Medicine, İstanbul, Turkey.
authors.forename: Sevgi
authors.initials: S
authors.lastname: Bilgen
authors.affiliation: Department of Anaesthesiology and Reanimation, Yeditepe University Faculty of Medicine, İstanbul, Turkey.
authors.forename: Özgül
authors.initials: Ö
authors.lastname: Keskin
authors.affiliation: Department of Anaesthesiology and Reanimation, Yeditepe University Faculty of Medicine, İstanbul, Turkey.
authors.forename: Sibel
authors.initials: S
authors.lastname: Temur
authors.affiliation: Department of Anaesthesiology and Reanimation, Yeditepe University Faculty of Medicine, İstanbul, Turkey.
authors.forename: Özge
authors.initials: Ö
authors.lastname: Köner
keywords: Laryngeal mask airway; flurbiprofen; sore throat