title: bioassayR: Cross-Target Analysis of Small Molecule Bioactivity.
abstract: Despite a large and rapidly growing body of small molecule bioactivity screens available in the public domain, systematic leverage of the data to assess target druggability and compound selectivity has been confounded by a lack of suitable cross-target analysis software. We have developed bioassayR, a computational tool that enables simultaneous analysis of thousands of bioassay experiments performed over a diverse set of compounds and biological targets. Unique features include support for large-scale cross-target analyses of both public and custom bioassays, generation of high throughput screening fingerprints (HTSFPs), and an optional preloaded database that provides access to a substantial portion of publicly available bioactivity data. bioassayR is implemented as an open-source R/Bioconductor package available from https://bioconductor.org/packages/bioassayR/ .
authors.affiliation: Institute for Integrative Genome Biology, University of California, Riverside , Riverside, California 92521, United States.
authors.forename: Tyler William H
authors.initials: TW
authors.lastname: Backman
authors.affiliation: Institute for Integrative Genome Biology, University of California, Riverside , Riverside, California 92521, United States.
authors.forename: Thomas
authors.initials: T
authors.lastname: Girke
mesh_terms: D001681:Biological Assay; D019295:Computational Biology / Q000379:methods*; D062313:Databases, Pharmaceutical; D054852:Small Molecule Libraries / Q000494:pharmacology*; D012984:Software
chemical_list: D054852:Small Molecule Libraries