title: Dynamic and modular gene regulatory networks drive the development of gametogenesis.
abstract: Gametogenesis is a complex process, which includes mitosis and meiosis and results in the production of ovum and sperm. The development of gametogenesis is dynamic and needs many different genes to work synergistically, but it is lack of global perspective research about this process. In this study, we detected the dynamic process of gametogenesis from the perspective of systems biology based on protein-protein interaction networks (PPINs) and functional analysis. Results showed that gametogenesis genes have strong synergistic effects in PPINs within and between different phases during the development. Addition to the synergistic effects on molecular networks, gametogenesis genes showed functional consistency within and between different phases, which provides the further evidence about the dynamic process during the development of gametogenesis. At last, we detected and provided the core molecular modules of different phases about gametogenesis. The gametogenesis genes and related modules can be obtained from our Web site Gametogenesis Molecule Online (GMO, http://gametsonline.nwsuaflmz.com/index.php), which is freely accessible. GMO may be helpful for the reference and application of these genes and modules in the future identification of key genes about gametogenesis. Summary, this work provided a computational perspective and frame to the analysis of the gametogenesis dynamics and modularity in both human and mouse.
authors.forename: Dongxue
authors.initials: D
authors.lastname: Che
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Weiyang
authors.initials: W
authors.lastname: Bai
authors.forename: Leijie
authors.initials: L
authors.lastname: Li
authors.forename: Guiyou
authors.initials: G
authors.lastname: Liu
authors.forename: Liangcai
authors.initials: L
authors.lastname: Zhang
authors.forename: Yongchun
authors.initials: Y
authors.lastname: Zuo
authors.forename: Shiheng
authors.initials: S
authors.lastname: Tao
authors.forename: Jinlian
authors.initials: J
authors.lastname: Hua
authors.forename: Mingzhi
authors.initials: M
authors.lastname: Liao
mesh_terms: D000818:Animals; D005718:Gametogenesis; D053263:Gene Regulatory Networks; D006801:Humans; D008540:Meiosis; D051379:Mice; D060066:Protein Interaction Maps; D049490:Systems Biology
keywords: Gametogenesis Molecule Online; dynamics; gametogenesis; modularity; protein–protein interaction network