title: Activation of human bitter taste receptors by polymethoxylated flavonoids.
abstract: Tangeretin and nobiletin are polymethoxylated flavonoids in citrus peel. Both tangeretin and nobiletin are bitter; however, their bitterness has not been evaluated using human bitter taste receptors (hTAS2Rs). We screened 25 kinds of hTAS2Rs and found that hTAS2R14 and hTAS2R46 received both compounds.
authors.affiliation: a Graduate School of Integrated Pharmaceutical and Nutritional Sciences , University of Shizuoka , Shizuoka , Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kuroda
authors.affiliation: a Graduate School of Integrated Pharmaceutical and Nutritional Sciences , University of Shizuoka , Shizuoka , Japan.
authors.forename: Riko
authors.initials: R
authors.lastname: Ikeda
authors.affiliation: a Graduate School of Integrated Pharmaceutical and Nutritional Sciences , University of Shizuoka , Shizuoka , Japan.
authors.forename: Toyomi
authors.initials: T
authors.lastname: Yamazaki
authors.affiliation: a Graduate School of Integrated Pharmaceutical and Nutritional Sciences , University of Shizuoka , Shizuoka , Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Ito
authors.affiliation: a Graduate School of Integrated Pharmaceutical and Nutritional Sciences , University of Shizuoka , Shizuoka , Japan.
authors.forename: Kazunari
authors.initials: K
authors.lastname: Uda
authors.affiliation: a Graduate School of Integrated Pharmaceutical and Nutritional Sciences , University of Shizuoka , Shizuoka , Japan.
authors.forename: Keiji
authors.initials: K
authors.lastname: Wakabayashi
authors.affiliation: a Graduate School of Integrated Pharmaceutical and Nutritional Sciences , University of Shizuoka , Shizuoka , Japan.
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Watanabe
mesh_terms: D047309:Flavones / Q000737:chemistry* / Q000494:pharmacology*; D057809:HEK293 Cells; D006801:Humans; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*
chemical_list: D047309:Flavones; D043562:Receptors, G-Protein-Coupled; C008661:nobiletin; C059006:tangeretin
keywords: hTAS2R14; hTAS2R46; nobiletin; polymethoxylated flavonoids; tangeretin