title: Retinal Pigment Epithelium Tear after Immunosuppressive Treatment for Sarcoidosis-related Choroidal Granuloma.
abstract: OBJECTIVE
  To describe the formation of a retinal pigment epithelial (RPE) tear following immunosuppressive treatment of a large choroidal granuloma in a patient with sarcoidosis-related panuveitis.
  
  
  METHODS
  A 25-year-old woman presented with bilateral sarcoidosis-related panuveitis and optic disc edema in both eyes with a large choroidal granuloma temporal to the fovea in the left eye. High-dose oral prednisone therapy was given.
  
  
  RESULTS
  High-dose oral prednisone therapy produced improvement in her panuveitis with reduction in size of the left choroidal granuloma. An RPE tear overlying the flattening choroidal granuloma developed by 3 weeks of treatment.
  
  
  CONCLUSIONS
  Treatment of choroidal granuloma with rapid reduction in size may result in an RPE tear.
authors.affiliation: a National Eye Institute, National Institutes of Health , Bethesda , Maryland , USA.
authors.forename: Jared E
authors.initials: JE
authors.lastname: Knickelbein
authors.affiliation: a National Eye Institute, National Institutes of Health , Bethesda , Maryland , USA.
authors.forename: Maggie
authors.initials: M
authors.lastname: Wei
authors.affiliation: a National Eye Institute, National Institutes of Health , Bethesda , Maryland , USA.
authors.forename: Robert B
authors.initials: RB
authors.lastname: Nussenblatt
authors.affiliation: a National Eye Institute, National Institutes of Health , Bethesda , Maryland , USA.
authors.forename: H Nida
authors.initials: HN
authors.lastname: Sen
mesh_terms: D000284:Administration, Oral; D000328:Adult; D015862:Choroid Diseases / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D005451:Fluorescein Angiography; D005938:Glucocorticoids / Q000009:adverse effects*; D006099:Granuloma / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D015864:Panuveitis / Q000150:complications; D011239:Prednisolone / Q000009:adverse effects*; D012167:Retinal Perforations / Q000139:chemically induced*; D055213:Retinal Pigment Epithelium / Q000187:drug effects*; D012507:Sarcoidosis / Q000150:complications*; D041623:Tomography, Optical Coherence
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone
keywords: Immunosuppression; panuveitis; pigment epithelial tear; sarcoidosis