title: Drug repositioning approaches to parasitic diseases: a medicinal chemistry perspective.
abstract: Identifying new indications for clinically useful drugs is a worthwhile approach for neglected tropical diseases. The number of successful repurposing cases in the field is growing as not-for-profit organizations, in association with academia and pharmaceutical companies, enable screening campaigns for the identification of new repositioning candidates. Current programs have delivered encouraging results as the use of state-of-the-art technologies, such as genomic and structural biology tools, and high-throughput screening platforms have become increasingly common in infectious disease research. Drug repositioning has played a key part in improving the lives of those suffering from these conditions, as evidenced by successful precedents and recent studies on preeminent parasitic disorders.
authors.affiliation: Laboratório de Química Medicinal e Computacional, Centro de Pesquisa e Inovação em Biodiversidade e Fármacos, Instituto de Física de São Carlos, Universidade de São Paulo, Av. João Dagnone 1100, 13563-120, São Carlos, SP, Brazil.
authors.forename: Leonardo G
authors.initials: LG
authors.lastname: Ferreira
authors.affiliation: Laboratório de Química Medicinal e Computacional, Centro de Pesquisa e Inovação em Biodiversidade e Fármacos, Instituto de Física de São Carlos, Universidade de São Paulo, Av. João Dagnone 1100, 13563-120, São Carlos, SP, Brazil. Electronic address: aandrico@ifsc.usp.br.
authors.forename: Adriano D
authors.initials: AD
authors.lastname: Andricopulo
mesh_terms: D000818:Animals; D002626:Chemistry, Pharmaceutical; D058492:Drug Repositioning; D006801:Humans; D058069:Neglected Diseases / Q000188:drug therapy; D010272:Parasitic Diseases / Q000188:drug therapy*; D014330:Tropical Medicine