title: Co-expression networks revealed potential core lncRNAs in the triple-negative breast cancer.
abstract: Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer with unfavorable outcome. It is urgent to explore novel biomarkers and potential therapeutic targets in this malignancy. Increasing knowledge of long noncoding RNAs (lncRNAs) significantly deepens our understanding of cancer biology. Here, we sequenced eight paired TNBC tumor tissues and non-cancerous tissues, and validated significantly differentially expressed lncRNAs. Gene ontology (GO) and pathway analysis were used to investigate the function of differentially expressed mRNAs. Further, potential core lncRNAs in TNBC were identified by co-expression networks. Kaplan-Meier analysis also indicated that breast cancer patients with lower expression level of rhabdomyosarcoma 2 associated transcript (RMST), one of the potential core lncRNAs, had worse overall survival. To the best of our knowledge, it was the first report that RMST was involved in breast cancer. Our research provided a rich resource to the research community for further investigating lncRNAs functions and identifying lncRNAs with diagnostic and therapeutic potentials in TNBC.
authors.affiliation: Department of Surgical Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China.
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.affiliation: Department of Surgical Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China.
authors.forename: Ye-Huan
authors.initials: YH
authors.lastname: Liu
authors.affiliation: Department of Surgical Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China.
authors.forename: Si-Yang
authors.initials: SY
authors.lastname: Dong
authors.affiliation: Department of Surgical Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China.
authors.forename: Zhi-Han
authors.initials: ZH
authors.lastname: Yao
authors.affiliation: Department of Surgical Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China.
authors.forename: Lin
authors.initials: L
authors.lastname: Lv
authors.affiliation: Department of Surgical Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China.
authors.forename: Rui-Min
authors.initials: RM
authors.lastname: Ma
authors.affiliation: Department of Surgical Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China.
authors.forename: Xuan-Xuan
authors.initials: XX
authors.lastname: Dai
authors.affiliation: Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, PR China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Surgical Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China. Electronic address: xiaohuazhang2015@sina.com.
authors.forename: Xiao-Hua
authors.initials: XH
authors.lastname: Zhang
authors.affiliation: Department of Surgical Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China. Electronic address: woconcology2000@163.com.
authors.forename: Ou-Chen
authors.initials: OC
authors.lastname: Wang
mesh_terms: D014408:Biomarkers, Tumor; D005260:Female; D020869:Gene Expression Profiling; D053263:Gene Regulatory Networks; D006801:Humans; D011379:Prognosis; D062085:RNA, Long Noncoding; D012334:RNA, Neoplasm; D060888:Real-Time Polymerase Chain Reaction; D064726:Triple Negative Breast Neoplasms / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; D062085:RNA, Long Noncoding; D012334:RNA, Neoplasm
keywords: Expression profile; Long non-coding RNA; RMST; Triple-negative breast cancer