title: Further evidence of VRK2 rs2312147 associated with schizophrenia.
abstract: OBJECTIVE
  Previous genome-wide association studies (GWAS) have reported that rs2312147 near the VRK2 gene was significantly associated with schizophrenia in populations of European descent, but negative results have also been observed.
  
  
  METHODS
  To perform a systematic meta-analysis, we collected statistical data of rs2312147 from both GWAS and individual replication samples in European and Asian populations, which finally included up to 30,867 schizophrenia patients and 59,863 healthy controls.
  
  
  RESULTS
  The VRK2 rs2312147 was genome-wide significantly associated with schizophrenia in combined populations (P = 1.31 × 10(-15), odds ratio, OR = 1.10) as well as in Europeans only (P = 2.35 × 10(-12), OR =1.09). In Asian samples, the SNP did not reach genome-wide level of statistical significance (P = 1.23 × 10 (-) (5), OR =1.19), which is likely due to the limited power of small sample size in this population (2,974 cases and 4,786 controls). However, the effect size of rs2312147 did not alter significantly between populations, and is also in agreement with the observed effect sizes of other genetic risk loci in large scale studies.
  
  
  CONCLUSIONS
  Our data provides further evidence for the genetic contributions of VRK2 rs2312147 to schizophrenia susceptibility especially in Europeans, while further replication analyses in Asian populations are still needed, and future studies, e.g., the underlying molecular mechanisms of genetic risk, are necessary.
authors.affiliation: a Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province , Kunming Institute of Zoology , Kunming , Yunnan , China ;
authors.forename: Hong
authors.initials: H
authors.lastname: Chang
authors.affiliation: b Division of Mood Disorders , Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine , Shanghai , China ;
authors.forename: Chen
authors.initials: C
authors.lastname: Zhang
authors.affiliation: a Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province , Kunming Institute of Zoology , Kunming , Yunnan , China ;
authors.forename: Xiao
authors.initials: X
authors.lastname: Xiao
authors.affiliation: c The Second People's Hospital of Yuxi City , Yuxi , Yunnan , China ;
authors.forename: Xingfu
authors.initials: X
authors.lastname: Pu
authors.affiliation: d Key Laboratory of Special Biological Resource Development and Utilization of Universities in Yunnan Province, Department of Biological Science and Technology , Kunming University , Kunming , Yunnan , China.
authors.forename: Zichao
authors.initials: Z
authors.lastname: Liu
authors.affiliation: a Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province , Kunming Institute of Zoology , Kunming , Yunnan , China ;
authors.forename: Lichuan
authors.initials: L
authors.lastname: Wu
authors.affiliation: a Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province , Kunming Institute of Zoology , Kunming , Yunnan , China ;
authors.forename: Ming
authors.initials: M
authors.lastname: Li
mesh_terms: D044466:Asian People / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D012044:Regression Analysis; D012559:Schizophrenia / Q000235:genetics*; D044465:White People / Q000235:genetics*
chemical_list: D017346:Protein Serine-Threonine Kinases; C109891:VRK2 protein, human
keywords: GWAS; VRK2; meta-analysis; rs2312147; schizophrenia