title: Gain-switched 311-nm Ti:Sapphire laser might be a potential treatment modality for atopic dermatitis.
abstract: Phototherapy with 311-nm narrowband-UVB (NBUVB) is an effective adjuvant treatment modality for atopic dermatitis (AD). In this study, we evaluated the therapeutic effect of the newly developed gain-switched 311-nm Ti:Sapphire laser device using a NC/Nga mouse AD model. A total number of 50 mice were used in this study. Atopic dermatitis (AD) was induced in mice by exposure to Dermatophagoides farina. These, NC/Nga mice were then treated with conventional 311-nm NBUVB or the newly developed gain-switched 311-nm Ti:Sapphire laser. The clinical features, dermatitis severity scores, and scratching behavior were assessed. In addition, serologic analyses including inflammatory cytokines and histological analyses were performed. Gain-switched 311-nm Ti:Sapphire laser improved the AD-like skin lesions, severity, and symptoms of AD in the NC/Nga mouse model. This new laser also modulated the immune response found in the AD model, including hyper-IgE, upregulated Th2 cytokines, and the Th2-mediated allergic inflammatory reaction. Gain-switched 311-nm Ti:Sapphire laser shows therapeutic promise via an immune-modulation mechanism in an AD mouse model. These data suggest that gain-switched 311-nm Ti:Sapphire laser may be useful as a targeted phototherapy modality for AD.
authors.affiliation: Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.|Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Choi
authors.affiliation: Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.
authors.forename: Chang Taek
authors.initials: CT
authors.lastname: Oh
authors.affiliation: Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.
authors.forename: Tae-Rin
authors.initials: TR
authors.lastname: Kwon
authors.affiliation: Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.
authors.forename: Hyun Jung
authors.initials: HJ
authors.lastname: Kwon
authors.affiliation: Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.
authors.forename: Eun Ja
authors.initials: EJ
authors.lastname: Choi
authors.affiliation: Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.|Department of Medicine, Graduate School, Chung-Ang University, Seoul, Korea.
authors.forename: Yu-Jin
authors.initials: YJ
authors.lastname: Jang
authors.affiliation: Laseroptek, #204, 31, Galmachi-ro 24, Jungwon, Seongnam, Kyunggi, Korea.
authors.forename: Hye Sung
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Laseroptek, #204, 31, Galmachi-ro 24, Jungwon, Seongnam, Kyunggi, Korea.
authors.forename: Hong
authors.initials: H
authors.lastname: Chu
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Chung-Ang University College of Medicine, Seoul, Korea.
authors.forename: Seog Kyun
authors.initials: SK
authors.lastname: Mun
authors.affiliation: Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.
authors.forename: Myeung Nam
authors.initials: MN
authors.lastname: Kim
authors.affiliation: Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea. beomjoon@unitel.co.kr.|Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. beomjoon@unitel.co.kr.|Department of Dermatology, Chung Ang University Hospital, 224-1 Heukseok-dong, Dongjak-ku, Seoul, 156-755, South Korea. beomjoon@unitel.co.kr.
authors.forename: Beom Joon
authors.initials: BJ
authors.lastname: Kim
mesh_terms: D000537:Aluminum Oxide / Q000737:chemistry*; D000818:Animals; D016207:Cytokines / Q000096:biosynthesis; D003876:Dermatitis, Atopic / Q000532:radiotherapy*; D004195:Disease Models, Animal; D006967:Hypersensitivity / Q000276:immunology / Q000473:pathology; D007073:Immunoglobulin E / Q000096:biosynthesis; D007249:Inflammation / Q000276:immunology / Q000473:pathology; D018836:Inflammation Mediators / Q000378:metabolism; D053685:Laser Therapy; D051379:Mice; D012867:Skin / Q000473:pathology / Q000528:radiation effects; D018418:Th2 Cells / Q000276:immunology
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D007073:Immunoglobulin E; D000537:Aluminum Oxide
keywords: Atopic dermatitis; Gain-switched 311-nm Ti:Sapphire laser