title: Recent advances in diagnosis and management of Mycotic Keratitis.
abstract: Mycotic keratitis is a major cause of corneal blindness, especially in tropical and subtropical countries. The prognosis is markedly worse compared to bacterial keratitis. Delayed diagnosis and scarcity of effective antifungal agents are the major factors for poor outcome. Over the last decade, considerable progress has been made to rapidly diagnose cases with mycotic keratitis and increase the efficacy of treatment. This review article discusses the recent advances in diagnosis and management of mycotic keratitis with a brief discussion on rare and emerging organisms. A MEDLINE search was carried out for articles in English language, with the keywords, mycotic keratitis, fungal keratitis, emerging or atypical fungal pathogens in mycotic keratitis, investigations in mycotic keratitis, polymerase chain reaction in mycotic keratitis, confocal microscopy, treatment of mycotic keratitis, newer therapy for mycotic keratitis. All relevant articles were included in this review. Considering the limited studies available on newer diagnostic and therapeutic modalities in mycotic keratitis, case series as well as case reports were also included if felt important.
authors.affiliation: Department of Ophthalmology, All India Institute of Medical Sciences, Bhubaneswar, India.
authors.forename: Prafulla K
authors.initials: PK
authors.lastname: Maharana
authors.affiliation: Cornea and Refractive Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Namrata
authors.initials: N
authors.lastname: Sharma
authors.affiliation: Department of Ophthalmology, L.V. Prasad Eye Institute, Hyderabad, India.
authors.forename: Ritu
authors.initials: R
authors.lastname: Nagpal
authors.affiliation: Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.
authors.forename: Vishal
authors.initials: V
authors.lastname: Jhanji
authors.affiliation: Department of Ophthalmology, L.V. Prasad Eye Institute, Bhubaneswar, India.
authors.forename: Sujata
authors.initials: S
authors.lastname: Das
authors.affiliation: Department of Ophthalmology, Vision Eye Institute, Royal Victorian Eye and Ear Hospital, North West Academic Centre, University of Melbourne, Australia.
authors.forename: Rasik B
authors.initials: RB
authors.lastname: Vajpayee
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D003315:Cornea / Q000382:microbiology* / Q000473:pathology; D019468:Disease Management; D015821:Eye Infections, Fungal / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D007634:Keratitis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D018613:Microscopy, Confocal
chemical_list: D000935:Antifungal Agents