title: [The impact of octacalcium phosphate on the dynamics of bone matrix formation in experimental bone defects].
abstract: The aim of the study was to assess the interaction of of octacalcium phosphate (OCP) with bone matrix and cells and its impact on the process of bone generation. The survey was conducted on animal model: critical hipbone defect was created in 12 230-250 g Wister rats. The animals were then divided in two groups. In group 1 (6 animals) defect was left to heal under blood clot and in group 2 (6 animals) it was filled with OCP. Three animals with no defect served as a control group. It was showed significant (p<0.05) increase of the area of the newly formed bone tissue and its direct correlation with duration of observation.
authors.affiliation: Central Scientific Research Institute of Dentistry and Maxillofacial Surgery, Moscow, Russia; I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
authors.forename: A N
authors.initials: AN
authors.lastname: Gurin
authors.affiliation: Central Scientific Research Institute of Dentistry and Maxillofacial Surgery, Moscow, Russia.
authors.forename: A S
authors.initials: AS
authors.lastname: Grigoryan
authors.affiliation: A.A. Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Moscow, Russia.
authors.forename: A Yu
authors.initials: AY
authors.lastname: Fedotov
authors.affiliation: A.A. Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Moscow, Russia.
authors.forename: V S
authors.initials: VS
authors.lastname: Komlev
mesh_terms: D000818:Animals; D001857:Bone Matrix / Q000166:cytology / Q000187:drug effects* / Q000254:growth & development; D018786:Bone Substitutes / Q000494:pharmacology*; D002130:Calcium Phosphates / Q000494:pharmacology*; D005269:Femur / Q000166:cytology / Q000187:drug effects / Q000293:injuries; D010012:Osteogenesis / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; C022045:octacalcium phosphate