title: Safety and efficacy of autologous serum eye drop for treatment of dry eyes in graft-versus-host disease.
abstract: OBJECTIVE
  To evaluate the treatment of autologous serum eye drops (ASED) on dry eyes in patients with graft-versus-host disease (GVHD).
  
  
  METHODS
  A retrospective chart review of 35 patients with a history of ocular GVHD following hematopoietic stem cell transplantation that used ASED to alleviate dry eye symptoms was performed. Patients were categorized into three different groups. If patients had available ophthalmic data before and after starting treatment was group 1 (n = 14), had available ophthalmic data after starting treatment in group 2 (n = 10) and had available ophthalmic data before treatment or did not have any data after starting treatment in group 3 (n = 11). Data were collected on patient's age, gender, primary diagnosis, visual acuity and fluorescein corneal staining were collected on individual eyes in order to evaluate the efficacy of the ASED on alleviating dry eye-related signs and symptoms.
  
  
  RESULTS
  No adverse ocular effect from the ASED was found in our series (except one fungal keratitis). All patients reported either improvement (55%) or stability (45%) in their ocular symptoms upon the use of ASED. In patients with available data before and after starting treatment, the corneal staining score improved by a median of 1 (p = 0.003) and the LogMAR visual acuity had a non-significant improvement.
  
  
  CONCLUSIONS
  In our study, ASED used by patients with ocular GVHD were both safe and effective. ASED should be considered in patients with GVHD who suffer from dry eyes.
authors.affiliation: a Thomas Jefferson School of Medicine , Wills Eye Hospital , Philadelphia, PA , USA.
authors.forename: Amir A
authors.initials: AA
authors.lastname: Azari
authors.affiliation: a Thomas Jefferson School of Medicine , Wills Eye Hospital , Philadelphia, PA , USA.|b School of Medicine , Istanbul Medeniyet University , Istanbul , Turkey.
authors.forename: Remzi
authors.initials: R
authors.lastname: Karadag
authors.affiliation: c Ocular Tissue Engineering Research Center , Shahid Beheshti University of Medical Sciences , Tehran , Iran.
authors.forename: Mozhgan Rezaei
authors.initials: MR
authors.lastname: Kanavi
authors.affiliation: d School of Medicine and Public Health , University of Wisconsin-Madison , Madison, WI , USA , and.
authors.forename: Sarah
authors.initials: S
authors.lastname: Nehls
authors.affiliation: d School of Medicine and Public Health , University of Wisconsin-Madison , Madison, WI , USA , and.
authors.forename: Neal
authors.initials: N
authors.lastname: Barney
authors.affiliation: e Department of Biostatistics and Medical Informatics , University of Wisconsin-Madison , Madison, WI , USA.
authors.forename: Kyungmann
authors.initials: K
authors.lastname: Kim
authors.affiliation: d School of Medicine and Public Health , University of Wisconsin-Madison , Madison, WI , USA , and.
authors.forename: Walter
authors.initials: W
authors.lastname: Longo
authors.affiliation: d School of Medicine and Public Health , University of Wisconsin-Madison , Madison, WI , USA , and.
authors.forename: Peiman
authors.initials: P
authors.lastname: Hematti
authors.affiliation: d School of Medicine and Public Health , University of Wisconsin-Madison , Madison, WI , USA , and.
authors.forename: Mark
authors.initials: M
authors.lastname: Juckett
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D015352:Dry Eye Syndromes / Q000276:immunology / Q000628:therapy*; D019573:Epithelium, Corneal / Q000276:immunology / Q000503:physiopathology; D005260:Female; D006086:Graft vs Host Disease / Q000276:immunology / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000009:adverse effects* / Q000627:therapeutic use; D012189:Retrospective Studies; D044967:Serum / Q000737:chemistry / Q000276:immunology*; D014182:Transplantation, Autologous / Q000379:methods; D014184:Transplantation, Homologous / Q000009:adverse effects; D014792:Visual Acuity / Q000276:immunology; D055815:Young Adult
chemical_list: D009883:Ophthalmic Solutions
keywords: Autologous serum eye drops; cornea; dry eye; graft-versus-host disease