title: Double benefit of long-acting somatostatin analogs in a patient with coexistence of acromegaly and ulcerative colitis.
abstract: OBJECTIVE
  Somatostatin analogs control GH/IGF-1 excess in acromegaly. Somatostatin receptors also mediate the complex effects of somatostatin on the gastrointestinal tract and may be defensive in inflammatory bowel diseases, such as ulcerative colitis. We present a patient who showed good response to long-acting octreotide (OCT-LAR) treatment in terms of both acromegaly and ulcerative colitis (UC).
  
  
  METHODS
  A 58-year-old female patient with diagnosis of acromegaly and ulcerative colitis was started on long-acting somatostatin treatment as a first-line treatment for acromegaly as she refused to undergo transsphenoidal surgery. During the follow-up period, a significant amelioration was also observed in the course of ulcerative colitis, and clinical remission of both diseases was achieved uneventfully.
  
  
  CONCLUSIONS
  Somatostatin appears to be a promising candidate in the treatment of inflammatory bowel diseases.
authors.affiliation: Department of Internal Medicine, Division of Endocrinology and Metabolic Diseases, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Yarman
authors.affiliation: Department of Internal Medicine, Division of Endocrinology and Metabolic Diseases, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: G Y
authors.initials: GY
authors.lastname: Yalın
authors.affiliation: Department of Internal Medicine, Division of Endocrinology and Metabolic Diseases, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: S C
authors.initials: SC
authors.lastname: Dogansen
authors.affiliation: Department of Internal Medicine, Division of Endocrinology and Metabolic Diseases, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Canbaz
authors.affiliation: Department of Internal Medicine, Division of Endocrinology and Metabolic Diseases, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Tanrıkulu
authors.affiliation: Department of Internal Medicine, Division of Gastroenterohepatology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: F
authors.initials: F
authors.lastname: Akyuz
mesh_terms: D000172:Acromegaly / Q000188:drug therapy*; D003093:Colitis, Ulcerative / Q000188:drug therapy* / Q000378:metabolism; D003692:Delayed-Action Preparations / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008875:Middle Aged; D015282:Octreotide / Q000008:administration & dosage; D013004:Somatostatin / Q000008:administration & dosage*
chemical_list: D003692:Delayed-Action Preparations; D013004:Somatostatin; D007334:Insulin-Like Growth Factor I; D015282:Octreotide
keywords: acromegaly; long-acting somatostatin analogs; ulcerative colitis