title: Correlation of transverse relaxation time with structure of biological tissue.
abstract: Transverse spin-spin relaxation of liquids entrapped in nanocavities with different orientational order is theoretically investigated. Based on the bivariate normal distribution of nanocavities directions, we have calculated the anisotropy of the transverse relaxation time for biological systems, such as collagenous tissues, articular cartilage, and tendon. In the framework of the considered model, the dipole-dipole interaction is determined by a single coupling constant. The calculation results for the transverse relaxation time explain the angular dependence observed in MRI experiments with biological objects. The good agreement with the experimental data is obtained by adjustment of only one parameter which characterizes the disorder in fiber orientations. The relaxation time is correlated with the degree of ordering in biological tissues. Thus, microstructure of the tissues can be revealed from the measurement of relaxation time anisotropy. The clinical significance of the correlation, especially in the detection of damage must be evaluated in a large prospective clinical trials.
authors.affiliation: Physics Department, Ben Gurion University of the Negev, Beer Sheva 84105, Israel. Electronic address: gregoryf@bgu.ac.il.
authors.forename: Gregory B
authors.initials: GB
authors.lastname: Furman
authors.affiliation: Physics Department, Ben Gurion University of the Negev, Beer Sheva 84105, Israel.
authors.forename: Victor M
authors.initials: VM
authors.lastname: Meerovich
authors.affiliation: Physics Department, Ben Gurion University of the Negev, Beer Sheva 84105, Israel.
authors.forename: Vladimir L
authors.initials: VL
authors.lastname: Sokolovsky
mesh_terms: D016880:Anisotropy; D002358:Cartilage, Articular / Q000000981:diagnostic imaging*; D006801:Humans; D008279:Magnetic Resonance Imaging; D013710:Tendons / Q000000981:diagnostic imaging*
keywords: Degree of ordering of fibers; MRI; Transverse relaxation time