title: Probiotics, Prebiotics & Food allergy Prevention: Clinical Data in Children.
abstract: there are accruing evidences on the role of the intestinal microbiota in the development of allergic diseases among infants. Elaborating on this theoretical basis, studies did assess the possibilities to prevent allergic diseases in infancy through manipulation of the intestinal microbiota. We review here such studies.
  
  
  
  interventional studies led to conflicting conclusions on the possible role of probiotics and prebiotics in allergy prevention. Two metanalyses published in 2015 did reconcile all data. Guidelines have been predicated on such studies using the GRADE methodology.
  
  
  
  the guidelines for allergy prevention suggest for the first time the use of probiotics and prebiotics. The existing evidences stand for a use of such supplementation in particular for the prevention of eczema. As there is no evidence so far of superiority of one probiotic strand over the others, they should be considered as class and not as individual products.
authors.affiliation: Allergy Department, The Bambino Gesù Children's Research Hospital, Rome Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Fiocchi
authors.forename: Valentina
authors.initials: V
authors.lastname: Pecora
authors.forename: Lamia
authors.initials: L
authors.lastname: Dahdah
mesh_terms: D002648:Child; D019317:Evidence-Based Medicine; D005512:Food Hypersensitivity / Q000517:prevention & control*; D006801:Humans; D007223:Infant; D017410:Practice Guidelines as Topic; D056692:Prebiotics / Q000008:administration & dosage*; D019936:Probiotics / Q000008:administration & dosage*
chemical_list: D056692:Prebiotics