title: Ibuprofen versus acetaminophen as a post-partum analgesic for women with severe pre-eclampsia: randomized clinical study.
abstract: OBJECTIVE
  To compare differences in blood pressure levels between patients with severe post-partum pre-eclampsia using ibuprofen or acetaminophen.
  
  
  METHODS
  A randomized controlled trial was made in women with severe pre-eclampsia or superimposed pre-eclampsia after vaginal birth. The patient was randomly selected to receive either 400 mg of ibuprofen every 8 h or 1 g of acetaminophen every 6 h during the post-partum. The primary variable was systolic hypertension ≥150 mmHg and/or diastolic hypertension ≥100 mmHg after the first 24 h post-partum. Secondary variables were the arterial blood pressure readings at 24, 48, 72, and 96 h post-partum and maternal complications.
  
  
  RESULTS
  A total of 113 patients were studied: 56 in the acetaminophen group and 57 in the ibuprofen group. With regard to the primary outcome, more cases were significantly hypertensive in the ibuprofen group (36/57; 63.1%) than in the acetaminophen group (16/56; 28.6%). Severe hypertension (≥160/110 mmHg) was not significantly different between the groups, 14.5% (acetaminophen) and 24.5% (ibuprofen). The levels of arterial blood pressure show a hammock-shaped curve independent of the drug used, however, is more noticeable with ibuprofen.
  
  
  CONCLUSIONS
  This study shows that ibuprofen significantly elevates blood pressure in women with severe pre-eclampsia during the post-partum period.
authors.affiliation: a Departamento de Ginecología y Obstetricia , Complejo hospitalario de la caja de seguro social, Unidad de CEGO , Panamá , Panama.
authors.forename: Paulino
authors.initials: P
authors.lastname: Vigil-De Gracia
authors.affiliation: a Departamento de Ginecología y Obstetricia , Complejo hospitalario de la caja de seguro social, Unidad de CEGO , Panamá , Panama.
authors.forename: Valentin
authors.initials: V
authors.lastname: Solis
authors.affiliation: a Departamento de Ginecología y Obstetricia , Complejo hospitalario de la caja de seguro social, Unidad de CEGO , Panamá , Panama.
authors.forename: Nelson
authors.initials: N
authors.lastname: Ortega
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage*; D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage* / Q000009:adverse effects; D049590:Postpartum Period; D011225:Pre-Eclampsia / Q000188:drug therapy* / Q000503:physiopathology; D011247:Pregnancy; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen; D007052:Ibuprofen
keywords: Acetaminophen; aggregate pre-eclampsia; ibuprofen; post-partum; severe pre-eclampsia,