title: Biological therapy and neurological manifestations. What do we know?
abstract: Biological therapy has changed the course of inflammatory rheumatic diseases. The safety is well documented in national and international studies. Neurological manifestations are uncommon and it is difficult to establish a clear causal relationship. The neurological signs and symptoms that may appear are multiple and sometimes mimic demyelinating neurological diseases and/or neurodegenerative diseases. Knowledge and disclosure of these cases is essential for a comprehensive management of biological therapy in our patients.
authors.affiliation: Servicio de Reumatología, Hospital Universitario de Canarias, Tenerife, España. Electronic address: btejerasegura@gmail.com.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Tejera-Segura
authors.affiliation: Servicio de Reumatología, Hospital Universitario de Canarias, Tenerife, España.
authors.forename: Iván
authors.initials: I
authors.lastname: Ferraz-Amaro
mesh_terms: D000911:Antibodies, Monoclonal / Q000009:adverse effects* / Q000627:therapeutic use; D018501:Antirheumatic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001691:Biological Therapy / Q000009:adverse effects*; D006801:Humans; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000175:diagnosis; D012216:Rheumatic Diseases / Q000188:drug therapy*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: D000911:Antibodies, Monoclonal; D018501:Antirheumatic Agents; D014409:Tumor Necrosis Factor-alpha
keywords: Anti-TNF alfa; Anti-TNF-alpha; Biological therapy; Enfermedades reumáticas inflamatorias; Inflammatory rheumatic diseases; Manifestaciones neurológicas; Neurological manifestations; Terapia biológica