title: Minireview: Syndecans and their crucial roles during tissue regeneration.
abstract: Syndecans are transmembrane heparan sulfate proteoglycans, with roles in development, tumorigenesis and inflammation, and growing evidence for involvement in tissue regeneration. This is a fast developing field with the prospect of utilizing tissue engineering and biomaterials in novel therapies. Syndecan receptors are not only ubiquitous in mammalian tissues, regulating cell adhesion, migration, proliferation, and differentiation through independent signaling but also working alongside other receptors. Their importance is highlighted by an ability to interact with a diverse array of ligands, including extracellular matrix glycoproteins, growth factors, morphogens, and cytokines that are important regulators of regeneration. We also discuss the potential for syndecans to regulate stem cell properties, and suggest that understanding these proteoglycans is relevant to exploiting cell, tissue, and materials technologies.
authors.affiliation: Department of Life Sciences and the Research Center for Cellular Homeostasis, Ewha Womans University, Seoul, Korea.
authors.forename: Heesung
authors.initials: H
authors.lastname: Chung
authors.affiliation: Department of Biomedical Sciences and Biotech Research & Innovation Center, University of Copenhagen, Denmark.
authors.forename: Hinke A B
authors.initials: HA
authors.lastname: Multhaupt
authors.affiliation: Department of Life Sciences and the Research Center for Cellular Homeostasis, Ewha Womans University, Seoul, Korea.
authors.forename: Eok-Soo
authors.initials: ES
authors.lastname: Oh
authors.affiliation: Department of Biomedical Sciences and Biotech Research & Innovation Center, University of Copenhagen, Denmark.
authors.forename: John R
authors.initials: JR
authors.lastname: Couchman
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000235:genetics; D002454:Cell Differentiation / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics; D006801:Humans; D007249:Inflammation / Q000235:genetics*; D008024:Ligands; D012038:Regeneration / Q000235:genetics*; D015398:Signal Transduction; D053667:Syndecans / Q000235:genetics*; D014945:Wound Healing
chemical_list: D008024:Ligands; D053667:Syndecans
keywords: extracellular matrix; growth factor; syndecan