title: Fullerene/photosensitizer nanovesicles as highly efficient and clearable phototheranostics with enhanced tumor accumulation for cancer therapy.
abstract: A novel phototheranostic platform based on tri-malonate derivative of fullerene C70 (TFC70)/photosensitizer (Chlorin e6, Ce6) nanovesicles (FCNVs) has been developed for effective tumor imaging and treatment. The FCNVs were prepared from amphiphilic TFC70-oligo ethylene glycol -Ce6 molecules. The developed FCNVs possessed the following advantages: (i) high loading efficiency of Ce6 (up to ∼57 wt%); (ii) efficient absorption in near-infrared light region; (iii) enhanced cellular uptake efficiency of Ce6 in vitro and in vivo; (iv) good biocompatibility and total clearance out from the body. These unique properties suggest that the as-prepared FCNVs could be applied as an ideal theranostic agent for simultaneous imaging and photodynamic therapy of tumor. This finding may provide a good solution to highly efficient phototheranostic applications based on fullerene derivatives fabricated nanostructures.
authors.affiliation: Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing National Laboratory for Molecular Sciences, Beijing 100190, China.
authors.forename: Mirong
authors.initials: M
authors.lastname: Guan
authors.affiliation: Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry (TIPC), Chinese Academy of Sciences, Beijing 100190, China. Electronic address: jchge2010@mail.ipc.ac.cn.
authors.forename: Jiechao
authors.initials: J
authors.lastname: Ge
authors.affiliation: Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing National Laboratory for Molecular Sciences, Beijing 100190, China.
authors.forename: Jingyi
authors.initials: J
authors.lastname: Wu
authors.affiliation: Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing National Laboratory for Molecular Sciences, Beijing 100190, China.
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing National Laboratory for Molecular Sciences, Beijing 100190, China.
authors.forename: Daiqin
authors.initials: D
authors.lastname: Chen
authors.affiliation: Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing National Laboratory for Molecular Sciences, Beijing 100190, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing National Laboratory for Molecular Sciences, Beijing 100190, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing National Laboratory for Molecular Sciences, Beijing 100190, China.
authors.forename: Toujun
authors.initials: T
authors.lastname: Zou
authors.affiliation: Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing National Laboratory for Molecular Sciences, Beijing 100190, China.
authors.forename: Mingming
authors.initials: M
authors.lastname: Zhen
authors.affiliation: Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing National Laboratory for Molecular Sciences, Beijing 100190, China.
authors.forename: Chunru
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
authors.forename: Taiwei
authors.initials: T
authors.lastname: Chu
authors.affiliation: Manufacturing Flagship, Commonwealth Scientific and Industrial Research Organization (CSIRO), Clayton, VIC 3168, Australia.
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Hao
authors.affiliation: Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing National Laboratory for Molecular Sciences, Beijing 100190, China. Electronic address: shucy@iccas.ac.cn.
authors.forename: Chunying
authors.initials: C
authors.lastname: Shu
mesh_terms: D000072283:A549 Cells; D065966:Absorption, Physicochemical; D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000528:radiation effects; D002735:Chlorophyllides; D004058:Diffusion; D005260:Female; D037741:Fullerenes / Q000737:chemistry*; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D053769:Nanocapsules / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure; D009374:Neoplasms, Experimental / Q000737:chemistry* / Q000188:drug therapy* / Q000473:pathology; D010316:Particle Size; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage* / Q000737:chemistry; D011166:Porphyrins / Q000008:administration & dosage* / Q000737:chemistry; D014018:Tissue Distribution; D016896:Treatment Outcome
chemical_list: D002735:Chlorophyllides; D037741:Fullerenes; D053769:Nanocapsules; D017319:Photosensitizing Agents; D011166:Porphyrins; C069836:fullerene C70; C062985:phytochlorin
keywords: Fullerene; Nanovesicle; Photosensitizer; Phototheranostic