title: MicroRNAs, heart failure, and aging: potential interactions with skeletal muscle.
abstract: MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression by targeting mRNAs for degradation or translational repression. MiRNAs can be expressed tissue specifically and are altered in response to various physiological conditions. It has recently been shown that miRNAs are released into the circulation, potentially for the purpose of communicating with distant tissues. This manuscript discusses miRNA alterations in cardiac muscle and the circulation during heart failure, a prevalent and costly public health issue. A potential mechanism for how skeletal muscle maladaptations during heart failure could be mediated by myocardium-derived miRNAs released to the circulation is presented. An overview of miRNA alterations in skeletal muscle during the ubiquitous process of aging and perspectives on miRNA interactions during heart failure are also provided.
authors.affiliation: Center for Muscle Biology, University of Kentucky, Lexington, KY, 40536, USA.|Department of Rehabilitation Sciences, College of Health Sciences, University of Kentucky, Lexington, KY, 40536, USA.
authors.forename: Kevin A
authors.initials: KA
authors.lastname: Murach
authors.affiliation: Center for Muscle Biology, University of Kentucky, Lexington, KY, 40536, USA. jjmcca2@uky.edu.|Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA. jjmcca2@uky.edu.
authors.forename: John J
authors.identifier: 0000-0003-4522-5601
authors.initials: JJ
authors.lastname: McCarthy
mesh_terms: D000818:Animals; D055354:Exosomes; D005786:Gene Expression Regulation; D006333:Heart Failure / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000096:biosynthesis / Q000235:genetics*; D018482:Muscle, Skeletal / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*
chemical_list: D035683:MicroRNAs
keywords: Aging; Exosomes; Heart failure; MicroRNA; Skeletal muscle