title: The Preclinical Research Progress of Stem Cells Therapy in Parkinson's Disease.
abstract: Parkinson's disease (PD) is a type of degenerative disorder of the basal ganglia, causing tremor at rest, muscle rigidity hypokinesia, and dementia. The effectiveness of drug treatments gradually diminishes because the conversion to dopamine within the brain is increasingly disrupted by the progressive degeneration of the dopaminergic terminals. After long-term treatment, most patients with PD suffer from disability that cannot be satisfactorily controlled. To solve these issues, stem cells have recently been used for cell therapy of PD. In this review, the characteristics of different stem cells and their therapeutic effects on PD treatment will be discussed.
authors.affiliation: Cell Therapy Laboratory, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, China.
authors.forename: Jun
authors.identifier: 0000-0003-3250-0897
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Cell Therapy Laboratory, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, China.
authors.forename: Xianyun
authors.initials: X
authors.lastname: Wang
authors.affiliation: Cell Therapy Laboratory, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, China; Department of Immunology, Basic Medical College, Hebei Medical University, Shijiazhuang, Hebei 050017, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Paediatrics, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Huang
authors.affiliation: Department of General Surgery, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, China.
authors.forename: Xuerui
authors.initials: X
authors.lastname: Yu
authors.affiliation: Department of Neurology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, China.
authors.forename: Ci
authors.initials: C
authors.lastname: Dong
authors.affiliation: Department of Cardiac Surgery, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, China.
authors.forename: Pujuan
authors.initials: P
authors.lastname: Liu
authors.affiliation: Cell Therapy Laboratory, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Zhang
authors.affiliation: School of Nursing, Hebei Medical University, Shijiazhuang, Hebei, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Hu
authors.affiliation: Department of Breast Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
authors.forename: Yixin
authors.initials: Y
authors.lastname: Qi
authors.affiliation: Department of Paediatrics, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Cell Therapy Laboratory, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, China; Department of Immunology, Basic Medical College, Hebei Medical University, Shijiazhuang, Hebei 050017, China.
authors.forename: Quanhai
authors.identifier: 0000-0003-3629-3856
authors.initials: Q
authors.lastname: Li
authors.affiliation: Cell Therapy Laboratory, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, China.
authors.forename: Baoyong
authors.identifier: 0000-0002-0876-2988
authors.initials: B
authors.lastname: Yan
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D004195:Disease Models, Animal; D006801:Humans; D010300:Parkinson Disease / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy*; D057905:Stem Cell Research; D033581:Stem Cell Transplantation / Q000379:methods*; D016896:Treatment Outcome