title: Airway Microbiota and the Implications of Dysbiosis in Asthma.
abstract: The mucosal surfaces of the human body are typically colonized by polymicrobial communities seeded in infancy and are continuously shaped by environmental exposures. These communities interact with the mucosal immune system to maintain homeostasis in health, but perturbations in their composition and function are associated with lower airway diseases, including asthma, a developmental and heterogeneous chronic disease with various degrees and types of airway inflammation. This review will summarize recent studies examining airway microbiota dysbioses associated with asthma and their relationship with the pathophysiology of this disease.
authors.affiliation: Department of Medicine, Division of Gastroenterology, University of California, San Francisco, CA, USA. Juliana.Durack@ucsf.edu.
authors.forename: Juliana
authors.initials: J
authors.lastname: Durack
authors.affiliation: Department of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, CA, USA.
authors.forename: Homer A
authors.initials: HA
authors.lastname: Boushey
authors.affiliation: Department of Medicine, Division of Gastroenterology, University of California, San Francisco, CA, USA.
authors.forename: Susan V
authors.initials: SV
authors.lastname: Lynch
mesh_terms: D001249:Asthma / Q000382:microbiology*; D064806:Dysbiosis / Q000382:microbiology*; D006801:Humans; D020545:Respiratory Mucosa / Q000382:microbiology*
keywords: Airway microbiome; Asthma; Asthma risk; Environment and asthma; Microbial dysbiosis