title: Inhibitors of programmed cell death 1 (PD-1): a patent review (2010-2015).
authors.affiliation: a Department of Drug Design , University of Groningen , Groningen , The Netherlands.
authors.forename: Tryfon
authors.initials: T
authors.lastname: Zarganes-Tzitzikas
authors.affiliation: a Department of Drug Design , University of Groningen , Groningen , The Netherlands.
authors.forename: Markella
authors.initials: M
authors.lastname: Konstantinidou
authors.affiliation: a Department of Drug Design , University of Groningen , Groningen , The Netherlands.
authors.forename: Yongzhi
authors.initials: Y
authors.lastname: Gao
authors.affiliation: b Malopolska Centre of Biotechnology , Jagiellonian University , Krakow , Poland.
authors.forename: Dobroslawa
authors.initials: D
authors.lastname: Krzemien
authors.affiliation: b Malopolska Centre of Biotechnology , Jagiellonian University , Krakow , Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Zak
authors.affiliation: b Malopolska Centre of Biotechnology , Jagiellonian University , Krakow , Poland.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Dubin
authors.affiliation: b Malopolska Centre of Biotechnology , Jagiellonian University , Krakow , Poland.|c Faculty of Chemistry , Jagiellonian University , Krakow , Poland.
authors.forename: Tad A
authors.initials: TA
authors.lastname: Holak
authors.affiliation: a Department of Drug Design , University of Groningen , Groningen , The Netherlands.
authors.forename: Alexander
authors.initials: A
authors.lastname: Dömling
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D060890:B7-H1 Antigen / Q000037:antagonists & inhibitors*; D015195:Drug Design; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D010330:Patents as Topic; D061026:Programmed Cell Death 1 Receptor / Q000037:antagonists & inhibitors*
chemical_list: D000970:Antineoplastic Agents; D060890:B7-H1 Antigen; C423236:CD274 protein, human; C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor
keywords: PD-1; PD-L1; Programmed death-1; T-cell exhaustion; immune checkpoint; immune-oncology