title: Epidemiology of major depressive disorder in South Africa (1997-2015): a systematic review protocol.
abstract: Major depressive disorder (MDD) is a leading cause of disease and disability globally and in South Africa. Epidemiological data for MDD are essential to estimate the overall disease burden in a country. The objective of the systematic review is to examine the evidence base for prevalence, incidence, remission, duration, severity, case fatality and excess mortality of MDD in South Africa from 1997 to 2015.
  
  
  
  We will perform electronic searches in PubMed, PsycINFO, Scopus and other bibliographical databases. Articles published between January 1997 and December 2015 will be eligible for inclusion in this review. The primary outcomes will be prevalence, incidence, remission, duration, severity, case fatality and excess mortality of MDD. The secondary outcomes will be risk factors and selected populations for MDD. If appropriate, a meta-analysis will be performed. If a meta-analysis is not possible, the review findings will be presented narratively and in tables. Subgroup analyses will be conducted with subgroups defined by population group, rural/urban settings and study designs, if sufficient data are available.
  
  
  
  The systematic review will use published data that are not linked to individuals. The review findings may have implications for future research prioritisation and disease modelling of MDD to estimate its morbidity burden in South Africa, and will be disseminated electronically and in print through peer-reviewed publications.
  
  
  
  International Prospective Register of Systematic Reviews (PROSPERO) CRD42015024885.
authors.affiliation: Burden of Disease Research Unit, South African Medical Research Council, Cape Town, South Africa.
authors.forename: Mweete D
authors.initials: MD
authors.lastname: Nglazi
authors.affiliation: Burden of Disease Research Unit, South African Medical Research Council, Cape Town, South Africa.
authors.forename: Jané D
authors.initials: JD
authors.lastname: Joubert
authors.affiliation: Department of Psychiatry & Mental Health, University of Cape Town, Cape Town, South Africa MRC Unit on Anxiety & Stress Disorders, Department of Psychiatry, Stellenbosch University, Cape Town, South Africa.
authors.forename: Dan J
authors.initials: DJ
authors.lastname: Stein
authors.affiliation: Alan Alan J Flisher Centre for Public Mental Health, Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa Centre for Global Mental Health, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
authors.forename: Crick
authors.initials: C
authors.lastname: Lund
authors.affiliation: Centre for Evidence-based Health Care, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa Cochrane South Africa, South African Medical Research Council, Cape Town, South Africa.
authors.forename: Charles S
authors.initials: CS
authors.lastname: Wiysonge
authors.affiliation: University of Washington, Institute for Health Metrics and Evaluation, Seattle, Washington, USA.
authors.forename: Theo
authors.initials: T
authors.lastname: Vos
authors.affiliation: Burden of Disease Research Unit, South African Medical Research Council, Cape Town, South Africa.
authors.forename: Victoria
authors.initials: V
authors.lastname: Pillay-van Wyk
authors.affiliation: Burden of Disease Research Unit, South African Medical Research Council, Cape Town, South Africa.
authors.forename: Rifqah A
authors.initials: RA
authors.lastname: Roomaney
authors.affiliation: Chronic Diseases Initiative for Africa, University of Cape Town, Cape Town, South Africa.
authors.forename: Lorrein S
authors.initials: LS
authors.lastname: Muhwava
authors.affiliation: Burden of Disease Research Unit, South African Medical Research Council, Cape Town, South Africa.
authors.forename: Debbie
authors.initials: D
authors.lastname: Bradshaw
mesh_terms: D003865:Major Depressive Disorder / Q000453:epidemiology*; D006801:Humans; D012107:Research Design; D013019:South Africa / Q000453:epidemiology; D000078202:Systematic Reviews as Topic
keywords: EPIDEMIOLOGY; PUBLIC HEALTH