title: Protective effect of two essential oils isolated from Rosa damascena Mill. and Lavandula angustifolia Mill, and two classic antioxidants against L-dopa oxidative toxicity induced in healthy mice.
abstract: Levodopa (L-dopa) is a "gold standard" and most effective symptomatic agent in the Parkinson's disease (PD) treatment. The several treatments have been developed in an attempt to improve PD treatment, but most patients were still levodopa dependent. The issue of toxicity was raised in vitro studies, and suggests that L-dopa can be toxic to dopaminergic neurons, but it is not yet entirely proven. L-dopa prolonged treatment is associated with motor complications and some limitations. Combining the L-dopa therapy with antioxidants can reduce related sideeffects and provide symptomatic relief. The natural antioxidants can be isolated from any plant parts such as seeds, leaves, roots, bark, etc., and their extracts riched in phenols can retard the oxidative degradation of the lipids, proteins and DNA. Thus, study suggests that combination of essential oils (Rose oil and Lavender oil), Vitamin C and Trolox with Ldopa can reduce oxidative toxicity, and may play a key role in ROS/RNS disarm.
authors.affiliation: Department of Chemistry and Biochemistry, Medical Faculty, Trakia University, 11 Armeiska Str., 6000 Stara Zagora, Bulgaria.
authors.forename: Galina
authors.initials: G
authors.lastname: Nikolova
authors.affiliation: Department of Chemistry and Biochemistry, Medical Faculty, Trakia University, 11 Armeiska Str., 6000 Stara Zagora, Bulgaria.
authors.forename: Yanka
authors.initials: Y
authors.lastname: Karamalakova
authors.affiliation: Agricultural Academy, Institute of Roses and Aromatic Plants, Kazanluk, Bulgaria.
authors.forename: Natasha
authors.initials: N
authors.lastname: Kovacheva
authors.affiliation: Agricultural Academy, Institute of Roses and Aromatic Plants, Kazanluk, Bulgaria.
authors.forename: Stanko
authors.initials: S
authors.lastname: Stanev
authors.affiliation: Department of Chemistry and Biochemistry, Medical Faculty, Trakia University, 11 Armeiska Str., 6000 Stara Zagora, Bulgaria. Electronic address: zhelleva.a@gmail.com.
authors.forename: Antoaneta
authors.initials: A
authors.lastname: Zheleva
authors.affiliation: Department of Chemistry and Biochemistry, Medical Faculty, Trakia University, 11 Armeiska Str., 6000 Stara Zagora, Bulgaria.
authors.forename: Veselina
authors.initials: V
authors.lastname: Gadjeva
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D000978:Antiparkinson Agents / Q000633:toxicity*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004249:DNA Damage; D027523:Lavandula / Q000737:chemistry*; D007980:Levodopa / Q000633:toxicity*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D051379:Mice; D009822:Oils, Volatile / Q000302:isolation & purification / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D010938:Plant Oils / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal; D050050:Protein Carbonylation / Q000187:drug effects; D026361:Reactive Nitrogen Species / Q000097:blood; D017382:Reactive Oxygen Species / Q000097:blood; D027826:Rosa / Q000737:chemistry*; D013053:Spectrophotometry
chemical_list: D000975:Antioxidants; D000978:Antiparkinson Agents; D009822:Oils, Volatile; D010936:Plant Extracts; D010938:Plant Oils; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D007980:Levodopa; D008315:Malondialdehyde
keywords: Antioxidant; DNA damage; L-dopa; Lipids; Protein carbonyl content