title: Predictive factors of mortality in pediatric patients with acute renal injury associated with sepsis.
abstract: OBJECTIVE
  To evaluate the prognosis factors of children with sepsis and acute kidney injury.
  
  
  METHODS
  This was a retrospective study of children with sepsis and acute kidney injury that were admitted to the pediatric intensive care unit (PICU) of a tertiary hospital. A multivariate analysis was performed to compare risk factors for mortality.
  
  
  RESULTS
  Seventy-seven children (47 males) were retrospectively studied, median age of 4 months. Mean length of hospital stay was 7.33±0.16 days, 68.9% of patients received mechanical ventilation, 25.9% had oligo-anuria, and peritoneal dialysis was performed in 42.8%. The pRIFLE criteria were: injury (5.2%) and failure (94.8%), and the staging system criteria were: stage 1 (14.3%), stage 2 (29.9%), and stage 3 (55.8%). The mortality rate was 33.7%. In the multivariate analysis, the risk factors for mortality were PICU length of stay (OR=0.615, SE=0.1377, 95% CI=0.469-0.805, p=0.0004); invasive mechanical ventilation (OR=14.599, SE=1.1178, 95% CI=1.673-133.7564, p=0.0155); need for dialysis (OR=9.714, SE=0.8088, 95% CI=1.990-47.410, p=0.0049), and hypoalbuminemia (OR=10.484, SE=1.1147, 95% CI=1.179-93.200, p=0.035).
  
  
  CONCLUSIONS
  The risk factors for mortality in children with acute kidney injury were associated with sepsis severity.
authors.affiliation: Universidade Estadual Paulista (UNESP), Faculdade de Medicina, Departamento de Pediatria, Botucatu, SP, Brazil. Electronic address: mriyuzo@fmb.unesp.br.
authors.forename: Marcia C
authors.initials: MC
authors.lastname: Riyuzo
authors.affiliation: Universidade Estadual Paulista (UNESP), Instituto de Biociências de Botucatu, Departamento de Bioestatística, Botucatu, SP, Brazil.
authors.forename: Liciana V de A
authors.initials: LV
authors.lastname: Silveira
authors.affiliation: Universidade Estadual Paulista (UNESP), Faculdade de Medicina, Departamento de Pediatria, Botucatu, SP, Brazil.
authors.forename: Célia S
authors.initials: CS
authors.lastname: Macedo
authors.affiliation: Universidade Estadual Paulista (UNESP), Faculdade de Medicina, Departamento de Pediatria, Botucatu, SP, Brazil.
authors.forename: José R
authors.initials: JR
authors.lastname: Fioretto
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology* / Q000401:mortality*; D001938:Brazil / Q000453:epidemiology; D005260:Female; D006801:Humans; D007223:Infant; D015278:Intensive Care Units, Pediatric; D007902:Length of Stay; D008297:Male; D015999:Multivariate Analysis; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D018805:Sepsis / Q000150:complications*; D016019:Survival Analysis
keywords: Acute kidney injury; Fatores preditivos; Lesão renal aguda; Mortalidade; Mortality; Predictive factors; Sepse; Sepsis