title: The Effect of Photoluminescence of Bioceramic Irradiation on Middle Cerebral Arterial Occlusion in Rats.
abstract: The purpose of this study is to determine the possible effect of photoluminescence of bioceramic (PLB) on ischemic cerebral infarction (stroke), by using an animal model of transient middle cerebral artery occlusion (MCAO). Sprague-Dawley rats were used to induce MCAO to block the origin of the left MCAO; three months later, the positive chronic stroke rats were selected by running tunnel maze; the MCAO rats with significant chronic stroke and neurological defects were used for treadmill experiments with varying speed settings to test their capability for restoration after muscular fatigue under conditions of with and without PLB irradiation. As a result, PLB irradiation could improve exercise completion rate and average running speed during slow and fast treadmill settings. After PLB irradiation, the selected MCAO rats successfully completed all the second-round treadmill exercises at the maximum speed setting, and they had better restoration from muscular fatigue. An in vitro cell study on astrocytes of rats by bioceramic irradiation further demonstrated increased intracellular nitric oxide. To explain these results, we suggest that cortical brain stimulation of microcirculation and enhancement of peripheral muscular activity are the main causes of the improved exercise performance in MCAO rats by PLB.
authors.affiliation: Department of Radiology, Shanghai East Hospital, Tongji University, 1800 Yantai Road, Shanghai 200123, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, No. 111, Sec. 3, Singlong Road, Taipei 116, Taiwan.
authors.forename: Paul
authors.initials: P
authors.lastname: Chan
authors.affiliation: Department of Cardiac Surgery, Shanghai East Hospital, Tongji University, 1800 Yantai Road, Shanghai 200123, China.
authors.forename: Zhong-Min
authors.initials: ZM
authors.lastname: Liu
authors.affiliation: Department of Physiology, Taipei Medical University, No. 250, Wu Hsing Street, Taipei 110, Taiwan.
authors.forename: Ling-Ling
authors.initials: LL
authors.lastname: Hwang
authors.affiliation: Department of Diagnostic Radiology, Cathay General Hospital, 280 Renai Road, Sec. 4, Taipei 106, Taiwan.
authors.forename: Kuo-Chi
authors.initials: KC
authors.lastname: Lin
authors.affiliation: Department of Radiology, Wan Fang Hospital, Taipei Medical University, No. 111, Sec. 3, Singlong Road, Taipei 116, Taiwan.
authors.forename: Wing P
authors.initials: WP
authors.lastname: Chan
authors.affiliation: Department of Radiology, Wan Fang Hospital, Taipei Medical University, No. 111, Sec. 3, Singlong Road, Taipei 116, Taiwan; Graduate Institute of Biomedical Materials and Tissue Engineering, College of Medical Engineering, Taipei Medical University, No. 250, Wu Hsing Street, Taipei 110, Taiwan; Department of Radiology, Taipei Hospital, Ministry of Health and Welfare, No. 127 Su Yuan Road, Hsinchuang District, New Taipei City 242-13, Taiwan.
authors.forename: Ting-Kai
authors.initials: TK
authors.lastname: Leung
authors.affiliation: Department of Emergency, Min-Sheng General Hospital, 168 Ching-Kuo Road, Taoyuan 330, Taiwan.
authors.forename: Cheuk Sing
authors.initials: CS
authors.lastname: Choy