title: Epigenomic maintenance through dietary intervention can facilitate DNA repair process to slow down the progress of premature aging.
abstract: DNA damage caused by various sources remains one of the most researched topics in the area of aging and neurodegeneration. Increased DNA damage causes premature aging. Aging is plastic and is characterised by the decline in the ability of a cell/organism to maintain genomic stability. Lifespan can be modulated by various interventions like calorie restriction, a balanced diet of macro and micronutrients or supplementation with nutrients/nutrient formulations such as Amalaki rasayana, docosahexaenoic acid, resveratrol, curcumin, etc. Increased levels of DNA damage in the form of double stranded and single stranded breaks are associated with decreased longevity in animal models like WNIN/Ob obese rats. Erroneous DNA repair can result in accumulation of DNA damage products, which in turn result in premature aging disorders such as Hutchinson-Gilford progeria syndrome. Epigenomic studies of the aging process have opened a completely new arena for research and development of drugs and therapeutic agents. We propose here that agents or interventions that can maintain epigenomic stability and facilitate the DNA repair process can slow down the progress of premature aging, if not completely prevent it. © 2016 IUBMB Life, 68(9):717-721, 2016.
authors.affiliation: Endocrinology and Metabolism Division, National Institute of Nutrition (NIN), Indian Council of Medical Research (ICMR), Hyderabad, 500007, India.
authors.forename: Shampa
authors.initials: S
authors.lastname: Ghosh
authors.affiliation: Endocrinology and Metabolism Division, National Institute of Nutrition (NIN), Indian Council of Medical Research (ICMR), Hyderabad, 500007, India.|Epigenetics and Neuropsychiatric Disease Laboratory, CSIR - Centre for Cellular and Molecular Biology (CCMB), Hyderabad, 500007, India.
authors.forename: Jitendra Kumar
authors.identifier: 0000-0002-7444-6932
authors.initials: JK
authors.lastname: Sinha
authors.affiliation: Endocrinology and Metabolism Division, National Institute of Nutrition (NIN), Indian Council of Medical Research (ICMR), Hyderabad, 500007, India.
authors.forename: Manchala
authors.initials: M
authors.lastname: Raghunath
mesh_terms: D000375:Aging / Q000187:drug effects / Q000235:genetics* / Q000473:pathology; D000818:Animals; D003474:Curcumin / Q000627:therapeutic use; D004249:DNA Damage / Q000235:genetics*; D004260:DNA Repair / Q000187:drug effects; D004281:Docosahexaenoic Acids / Q000627:therapeutic use; D044127:Epigenesis, Genetic / Q000235:genetics*; D042822:Genomic Instability / Q000187:drug effects; D006801:Humans; D008136:Longevity / Q000187:drug effects; D010936:Plant Extracts / Q000627:therapeutic use; D011371:Progeria / Q000178:diet therapy* / Q000503:physiopathology; D051381:Rats; D000077185:Resveratrol; D013267:Stilbenes / Q000627:therapeutic use
chemical_list: C574902:Amalakirasayana; D010936:Plant Extracts; D013267:Stilbenes; D004281:Docosahexaenoic Acids; D003474:Curcumin; D000077185:Resveratrol
keywords: Amalaki rasayana; DNA damage and repair; accelerated aging; epigenome maintenance; longevity