title: Population Pharmacokinetics of Tracers: A New Tool for Medical Imaging?
abstract: Positron emission tomography-computed tomography is a medical imaging method measuring the activity of a radiotracer chosen to accumulate in cancer cells. A recent trend of medical imaging analysis is to account for the radiotracer's pharmacokinetic properties at a voxel (three-dimensional-pixel) level to separate the different tissues. These analyses are closely linked to population pharmacokinetic-pharmacodynamic modelling. Kineticists possess the cultural background to improve medical imaging analysis. This article stresses the common points with population pharmacokinetics and highlights the methodological locks that need to be lifted.
authors.affiliation: CRCT, Université de Toulouse, Inserm, UPS, Toulouse, France.|Laboratoire de Pharmacocinétique et Toxicologie, Institut Fédératif de Biologie, CHU Purpan, Toulouse, France.
authors.forename: Peggy
authors.initials: P
authors.lastname: Gandia
authors.affiliation: Department of Radiotherapy, UZ Brussel, Brussels, Belgium.
authors.forename: Cyril
authors.initials: C
authors.lastname: Jaudet
authors.affiliation: CRCT, Université de Toulouse, Inserm, UPS, Toulouse, France.|Institut Claudius-Regaud, IUCT-Oncopole, Toulouse, France.
authors.forename: Etienne
authors.initials: E
authors.lastname: Chatelut
authors.affiliation: Toxalim, Université de Toulouse, INRA, ENVT, 23 chemin des Capelles, BP 8761, 31076, Toulouse cedex 3, France. d.concordet@envt.fr.
authors.forename: Didier
authors.initials: D
authors.lastname: Concordet
mesh_terms: D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism; D003952:Diagnostic Imaging / Q000379:methods; D005910:Glioma / Q000000981:diagnostic imaging / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D010599:Pharmacokinetics; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods; D011849:Radioactive Tracers
chemical_list: D011849:Radioactive Tracers