title: Osteopontin and Integrin αvβ3 Expression during the Implantation Window in IVF Patients with Elevated Serum Progesterone and Oestradiol Level.
abstract: Background:To explore whether endometrial receptivity is determined by osteopontin (OPN) and integrin αvβ3 expression in women with elevated serum progesterone (P) and/or oestradiol (E2) who are undergoing in vitro fertilisation (IVF).Methods:According to serum hormone levels on the day of HCG administration, 33 infertile women were divided into 3 groups: the high E2, high P, and high E2and P groups. The control group included 11 fertile, healthy women. Endometrial biopsy was performed on ovulation day + 7 to + 8 for all study participants, and the mRNA and protein expression levels of OPN and integrin αvβ3 were analyzed.Result:No statistically significant differences regarding OPN and integrin αvβ3 expression were found between infertile patients in the high P, high E2, high E2and P and control groups. There was no significant correlation between OPN and integrin αvβ3 staining intensity during the implantation window biopsy in any of the groups studied.Conclusion:Endometrial OPN and integrant αvβ3 expression/co-expression is not impaired during the window of implantation in patients with high P, high E2, or high E2and P levels. The clinical value of assessing endometrial receptivity with OPN and integrin αvβ3 seems to be uncertain.
authors.affiliation: Department of Reproduction and Genetics, Reproductive Medical Centre, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, People's Republic of China.
authors.forename: Z
authors.initials: Z
authors.lastname: He
authors.affiliation: Department of Reproduction and Genetics, Reproductive Medical Centre, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, People's Republic of China.
authors.forename: Y
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Department of Reproduction and Genetics, Reproductive Medical Centre, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, People's Republic of China.
authors.forename: L
authors.initials: L
authors.lastname: Li
authors.affiliation: Institute of Molecular and Clinical Medicine, Kunming Medical University, Chengong New District, Kunming, People's Republic of China.
authors.forename: J
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Pathology, The First People's Hospital of Yunnan Province, Kunming, People's Republic of China.
authors.forename: H
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Obstetrics and Gynecology, Reproductive Medical Centre, Peking University Third Hospital, Haidian District, Beijing, People's Republic of China.
authors.forename: C
authors.initials: C
authors.lastname: Chen
authors.affiliation: Department of Reproduction and Genetics, Reproductive Medical Centre, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, People's Republic of China.
authors.forename: N
authors.initials: N
authors.lastname: Lin
authors.affiliation: Department of Reproduction and Genetics, Reproductive Medical Centre, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, People's Republic of China.
authors.forename: Y
authors.initials: Y
authors.lastname: Bai
authors.affiliation: Department of Reproduction and Genetics, Reproductive Medical Centre, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, People's Republic of China.
authors.forename: R
authors.initials: R
authors.lastname: Ma
authors.affiliation: Department of Obstetrics and Gynecology, Reproductive Medical Centre, Peking University Third Hospital, Haidian District, Beijing, People's Republic of China.
authors.forename: R
authors.initials: R
authors.lastname: Li
authors.affiliation: Department of Reproduction and Genetics, Reproductive Medical Centre, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, People's Republic of China.
authors.forename: Z
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Department of Obstetrics and Gynecology, Reproductive Medical Centre, Peking University Third Hospital, Haidian District, Beijing, People's Republic of China.
authors.forename: J
authors.initials: J
authors.lastname: Qiao
keywords: IVF; elevated hormone levels; endometrial receptivity; integrin αvβ3; osteopontin