title: Association of Biomarkers of Inflammation and Endothelial Dysfunction with Fasting and Postload Glucose Metabolism: A Population-Based Prospective Cohort Study Among Inner Mongolians in China.
abstract: OBJECTIVE
  To examine the associations between elevated levels of C-reactive protein (CRP), soluble intercellular adhesion molecule-1 (sICAM-1) and soluble E-selectin (sE-selectin) with fasting and 2-hour postload glucometabolic status among Inner Mongolians in China.
  
  
  METHODS
  Based on a cross-sectional survey of patients during 2003, 2260 participants were reinvestigated between 2013 and 2014. We categorized the participants into 3 subgroups according to fasting and postload glucose levels, respectively. The associations between biomarkers of inflammation and endothelial dysfunction and deterioration of fasting and postload glucometabolic status were examined by ordinal logistic regression analysis.
  
  
  RESULTS
  We found 142 and 49 persons who had impaired fasting glucose (IFG) levels and type 2 diabetes in the fasting state and 335 and 50 persons who had impaired glucose tolerance (IGT) and type 2 diabetes in the postload state. After multivariable adjustment, elevated CRP and sICAM-1 levels were associated with deterioration of fasting glucometabolic status from normal fasting glucose to IFG and type 2 diabetes (odds ratio [OR] 1.73 [95% CI 1.18 to 2.54] for elevated CRP levels, OR 1.86 [95% CI 1.30 to 2.66] for elevated sICAM-1 levels). Elevated sE-selectin levels were associated with deterioration of postload glucometabolic status from normal glucose tolerance to IGT and type 2 diabetes (OR 1.34 [95% CI 1.01 to 1.77]) in the multivariable-adjusted model.
  
  
  CONCLUSIONS
  Biomarkers of inflammation and endothelial dysfunction were separately associated with fasting and postload glucose metabolism among Inner Mongolians.
authors.affiliation: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Jiangsu, China.
authors.forename: Jiahui
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Jiangsu, China.
authors.forename: Zhu
authors.initials: Z
authors.lastname: Liang
authors.affiliation: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Jiangsu, China.
authors.forename: Jingwen
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Jiangsu, China.
authors.forename: Chongke
authors.initials: C
authors.lastname: Zhong
authors.affiliation: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Jiangsu, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Jiang
authors.affiliation: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Jiangsu, China; Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Soochow University, China.
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Jiangsu, China; Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Soochow University, China. Electronic address: zhangsy@suda.edu.cn.
authors.forename: Shaoyan
authors.initials: S
authors.lastname: Zhang
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D019040:E-Selectin / Q000378:metabolism; D004730:Endothelium, Vascular / Q000378:metabolism / Q000473:pathology*; D005215:Fasting; D005260:Female; D005500:Follow-Up Studies; D018149:Glucose Intolerance; D005951:Glucose Tolerance Test; D006801:Humans; D007249:Inflammation / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D008986:Mongolia; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D019040:E-Selectin; D018799:Intercellular Adhesion Molecule-1; D002097:C-Reactive Protein
keywords: BIomarqueurs; biomarkers; diabetes; diabète; fasting glucose; glycémie à jeun; postload glucose prospective; prévision de la glycémie postprandiale