title: Lid Wiper Epitheliopathy in Soft Contact Lens Wearers.
abstract: To evaluate lid wiper epitheliopathy (LWE) in soft contact lens (SCL) wearers on initial presentation and after using various SCL and solution combinations.
  
  
  
  LWE was assessed in 253 habitual SCL wearers who attended a screening visit at one of three study sites. LWE was assessed using lissamine green and sodium fluorescein dyes (Korb scale); a final LWE grade was calculated as the averaged LWE grade of the two dyes. Eligible habitual wearers continued into the four study periods, during which they wore one of three SCL types (etafilcon A, galyfilcon A, or senofilcon A) while using each of four care solutions for 10 to 14 days in randomized order. Statistical analyses were performed using linear mixed models, testing for differences in LWE for subject characteristics and between three multipurpose (MPS) test solutions (BioTrue, OPTI-FREE PureMoist, RevitaLens OcuTec) compared to a hydrogen peroxide (Clear Care) control solution.
  
  
  
  LWE was present in 85% of habitual SCL wearers. LWE was not different for age (p = 0.28), sex (p = 0.99), race (p = 0.34), and comfort (p = 0.38) and not correlated with refractive error (r = 0.07). LWE was lower in habitual senofilcon A wearers (least-squares (LS) mean ± SE = 0.82 ± 0.19) compared to wearers of lotrafilcon B (1.34 ± 0.20; p < 0.02), comfilcon A (1.41 ± 0.21; p < 0.01), and other (1.18 ± 0.16; p < 0.03). Two hundred three participants completed all four study solutions with their assigned lens type; LWE was not different between the MPSs compared to the peroxide control solution across lens materials, except for less LWE for BioTrue (0.88 ± 0.17) versus Clear Care for participants wearing galyfilcon A (1.11 ± 0.18; p < 0.01).
  
  
  
  On initial presentation, LWE was present in 85% of habitual wearers and found to be independent of age, sex, race, comfort, and refractive error but dependent on habitual SCL type. There were no clinically meaningful differences in LWE between the MPSs and hydrogen peroxide solution for the three lens types studied.
authors.affiliation: *DiplIng(AO), PhD, FAAO †BSOptom, PhD, FAAO ‡BSc, MCOptom, FAAO §OD, PhD, FAAO ∥BSc(Hons), MCOptom **MSc ††BSc(Hons), PhD, MCOptom FAAO ‡‡OD, MPH, PhD, FAAO §§PhD, FCOptom, FAAO Centre for Contact Lens Research, School of Optometry and Vision Science, University of Waterloo, Waterloo, Ontario, Canada (M-MS, SS, LWJ); Johnson and Johnson Vision Care, Inc., Jacksonville, Florida (SBH-C, YT); The Ocular Surface Institute, College of Optometry, University of Houston, Houston, Texas (DAB); Eurolens Research, University of Manchester, Manchester, United Kingdom (GFH, PM); and School of Optometry, The University of Alabama at Birmingham, Birmingham, Alabama (JJN).
authors.forename: Marc-Matthias
authors.initials: MM
authors.lastname: Schulze
authors.forename: Sruthi
authors.initials: S
authors.lastname: Srinivasan
authors.forename: Sheila B
authors.initials: SB
authors.lastname: Hickson-Curran
authors.forename: David A
authors.initials: DA
authors.lastname: Berntsen
authors.forename: Gillian F
authors.initials: GF
authors.lastname: Howarth
authors.forename: Youssef
authors.initials: Y
authors.lastname: Toubouti
authors.forename: Philip
authors.initials: P
authors.lastname: Morgan
authors.forename: Jason J
authors.initials: JJ
authors.lastname: Nichols
authors.forename: Lyndon W
authors.initials: LW
authors.lastname: Jones
mesh_terms: D000328:Adult; D018639:Contact Lens Solutions / Q000494:pharmacology*; D003263:Contact Lenses, Hydrophilic / Q000009:adverse effects*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005141:Eyelid Diseases / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control; D005143:Eyelids / Q000187:drug effects / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male
chemical_list: D018639:Contact Lens Solutions