title: Controlling the Reversible Assembly of Liposomes through a Multistimuli Responsive Anchored DNA.
abstract: We present a novel approach to reversibly control the assembly of liposomes through an anchored multistimuli responsive DNA oligonucleotide decorated with an azobenzene moiety (AZO-ON1). We show that liposomes assembly can be simultaneously controlled by three external stimuli: light, Mg(2+), and temperature. (i) Light alters the interaction of AZO-ON1 with liposomes, which influences DNA coating and consequently liposomes assembly. (ii) Mg(2+) induces the assembly, hence variation in its concentration enables for reversibility. (iii) Double-stranded AZO-ON1 is more efficient than single-stranded AZO-ON1 in triggering the assembly of liposomes and temperature has been used for controllable assembly through DNA thermal denaturation. Our multiresponsive AZO-ON1 represents a unique example in which multiple stimuli can be simultaneously applied to regulate the reversible assembly of liposomes.
authors.affiliation: Cavendish Laboratory, Department of Physics, University of Cambridge , JJ Thomson Avenue, Cambridge, CB3 0HE, United Kingdom.
authors.forename: Silvia
authors.initials: S
authors.lastname: Hernández-Ainsa
authors.affiliation: Cavendish Laboratory, Department of Physics, University of Cambridge , JJ Thomson Avenue, Cambridge, CB3 0HE, United Kingdom.
authors.forename: Maria
authors.initials: M
authors.lastname: Ricci
authors.affiliation: Cavendish Laboratory, Department of Physics, University of Cambridge , JJ Thomson Avenue, Cambridge, CB3 0HE, United Kingdom.
authors.forename: Lloyd
authors.initials: L
authors.lastname: Hilton
authors.affiliation: IQAC-CSIC, CIBER-BBN Networking Centre on Bioengineering, Biomaterials and Nanomedicine , c/Jordi Girona 18-26, 08034 Barcelona, Spain.
authors.forename: Anna
authors.initials: A
authors.lastname: Aviñó
authors.affiliation: IQAC-CSIC, CIBER-BBN Networking Centre on Bioengineering, Biomaterials and Nanomedicine , c/Jordi Girona 18-26, 08034 Barcelona, Spain.
authors.forename: Ramon
authors.initials: R
authors.lastname: Eritja
authors.affiliation: Cavendish Laboratory, Department of Physics, University of Cambridge , JJ Thomson Avenue, Cambridge, CB3 0HE, United Kingdom.
authors.forename: Ulrich F
authors.initials: UF
authors.lastname: Keyser
mesh_terms: D001391:Azo Compounds; D004247:DNA / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D009841:Oligonucleotides / Q000737:chemistry*; D013696:Temperature
chemical_list: D001391:Azo Compounds; D008081:Liposomes; D009841:Oligonucleotides; D004247:DNA
keywords: DNA; azobenzene; liposomes; self-assembly; stimuli-responsive materials