title: Contemplating Bretscher's View that the Tritope Model is 'Implausible'.
abstract: There is, at present, only two models of the TCR structure-function relationship. These are referred to here as the Standard (Centric) model and the Tritope model. While I have argued that the Standard model is untenable and proposed the Tritope to replace it, Bretscher has argued that the Tritope model is 'implausible' and throws his support for the Standard model. This essay analyses the implausibility argument concluding that it is unfounded.
authors.affiliation: Conceptual Immunology Group, The Salk Institute, La Jolla, CA, USA.
authors.forename: M
authors.initials: M
authors.lastname: Cohn
mesh_terms: D000483:Alleles; D000939:Epitopes / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D005786:Gene Expression Regulation; D006801:Humans; D018448:Models, Immunological; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics / Q000276:immunology; D011947:Receptors, Antigen, B-Cell / Q000737:chemistry / Q000235:genetics / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D015398:Signal Transduction; D040681:Structural Homology, Protein
chemical_list: D000939:Epitopes; D020033:Protein Isoforms; D011947:Receptors, Antigen, B-Cell; D011948:Receptors, Antigen, T-Cell