title: Pleosporalone A, the first azaphilone characterized with aromatic A-ring from a marine-derived Pleosporales sp. fungus.
abstract: A fungal strain, Pleosporales sp. CF09-1, was isolated from marine sediment collected from the Bohai Sea. A novel azaphilone derivative, named pleosporalone A (1), along with two known analogues, cohaerins A and B (2 and 3), were obtained and identified from the culture extract of Pleosporales sp. CF09-1. Their planar structures were elucidated by detailed analysis of spectroscopic data and by comparison with related known compounds. Pleosporalone A (1) represents the first azaphilone derivative characterised with A-ring aromatisation. Compound 1 showed strong antifungal activity against three plant pathogenic fungi Botrytis cinerea, Rhizopus oryzae and Phytophthora capsici with the MIC values of 0.39, 0.78 and 0.78 μM, respectively.
authors.affiliation: a Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences , Hebei University , Baoding , People's Republic of China.
authors.forename: Fei
authors.initials: F
authors.lastname: Cao
authors.affiliation: a Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences , Hebei University , Baoding , People's Republic of China.
authors.forename: Jian-Kun
authors.initials: JK
authors.lastname: Yang
authors.affiliation: a Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences , Hebei University , Baoding , People's Republic of China.
authors.forename: Yun-Feng
authors.initials: YF
authors.lastname: Liu
authors.affiliation: a Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences , Hebei University , Baoding , People's Republic of China.
authors.forename: Hua-Jie
authors.initials: HJ
authors.lastname: Zhu
authors.affiliation: b Key Laboratory of Marine Drugs, the Ministry of Education of China, School of Medicine and Pharmacy , Ocean University of China , Qingdao , People's Republic of China.
authors.forename: Chang-Yun
authors.initials: CY
authors.lastname: Wang
mesh_terms: D001203:Ascomycota / Q000378:metabolism*; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020171:Botrytis / Q000187:drug effects; D005659:Fungicides, Industrial / Q000494:pharmacology; D019015:Geologic Sediments / Q000382:microbiology*; D010838:Phytophthora / Q000187:drug effects; D010860:Pigments, Biological / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D001578:Benzopyrans; D005659:Fungicides, Industrial; D010860:Pigments, Biological; C494154:azaphilone; C000617460:pleosporalone A
keywords: Marine sediment; Pleosporales sp; antifungal activity; azaphilone derivative