title: Effect of a booster dose of influenza vaccine in patients with hemodialysis, peritoneal dialysis and renal transplant recipients: A systematic literature review and meta-analysis.
abstract: Booster influenza vaccination has been recommended for patients with chronic renal disease in order to enhance the immune response to the influenza vaccine; however, the efficacy of a booster influenza vaccination is a matter of controversy. Therefore, we made a meta-analysis to determine the efficacy in patients with hemodialysis (HD), peritoneal dialysis (PD) and renal transplant recipient (RT). The sero-protection rate was used as a serologic parameter to describe the immune response to the vaccine. Statistical analysis was performed to calculate the pooled rate difference (RD) and 95% confidence interval (CI). The pooled RD for the H1N1, H3N2 and B influenza vaccines was 0.02 (95% CI: -0.02-0.06), 0.05 (95% CI: -0.01-0.11), 0.04 (95% CI: -0.02-0.10), respectively. We concluded that a booster dose of the influenza vaccine did not effectively enhance immunogenicity. Therefore, a booster dose of vaccine is not recommended for patients with hemodialysis, peritoneal dialysis and renal transplant recipients.
authors.affiliation: a Department of Epidemiology and Biostatistics , Guangdong Medical University , Dongguan , China.|b Dongguan Key Laboratory of Environmental Medicine , Guangdong Medical University , Dongguan , China.
authors.forename: Zhengfa
authors.initials: Z
authors.lastname: Liao
authors.affiliation: a Department of Epidemiology and Biostatistics , Guangdong Medical University , Dongguan , China.|b Dongguan Key Laboratory of Environmental Medicine , Guangdong Medical University , Dongguan , China.
authors.forename: Xiaojia
authors.initials: X
authors.lastname: Xu
authors.affiliation: a Department of Epidemiology and Biostatistics , Guangdong Medical University , Dongguan , China.|b Dongguan Key Laboratory of Environmental Medicine , Guangdong Medical University , Dongguan , China.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Liang
authors.affiliation: c School Clinic , Guangdong Medical University , Dongguan , China.
authors.forename: Yongzhen
authors.initials: Y
authors.lastname: Xiong
authors.affiliation: a Department of Epidemiology and Biostatistics , Guangdong Medical University , Dongguan , China.|d Centre for Health and Social Care Improvement , Faculty of Education, Health and Wellbeing, University of Wolverhampton , Wolverhampton , UK.
authors.forename: Ruoling
authors.initials: R
authors.lastname: Chen
authors.affiliation: a Department of Epidemiology and Biostatistics , Guangdong Medical University , Dongguan , China.|b Dongguan Key Laboratory of Environmental Medicine , Guangdong Medical University , Dongguan , China.
authors.forename: Jindong
authors.initials: J
authors.lastname: Ni
mesh_terms: D006801:Humans; D007117:Immunization, Secondary; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D007251:Influenza, Human / Q000517:prevention & control*; D016030:Kidney Transplantation; D010530:Peritoneal Dialysis; D006435:Renal Dialysis; D051437:Renal Insufficiency / Q000150:complications / Q000628:therapy; D066027:Transplant Recipients
chemical_list: D007252:Influenza Vaccines
keywords: hemodialysis; immunogenicity; influenza vaccine; meta-analysis; peritoneal dialysis; renal transplant recipient