title: Additive Effect of Qidan Dihuang Grain, a Traditional Chinese Medicine, and Angiotensin Receptor Blockers on Albuminuria Levels in Patients with Diabetic Nephropathy: A Randomized, Parallel-Controlled Trial.
abstract: Albuminuria is characteristic of early-stage diabetic nephropathy (DN). The conventional treatments with angiotensin receptor blockers (ARB) are unable to prevent the development of albuminuria in normotensive individuals with type 2 diabetes mellitus (T2DM). Purpose. The present study aimed to evaluate the effect of ARB combined with a Chinese formula Qidan Dihuang grain (QDDHG) in improving albuminuria and Traditional Chinese Medicine Symptom (TCMS) scores in normotensive individuals with T2DM. Methods. Eligible patients were randomized to the treatment group and the control group. Results. Compared with baseline (week 0), both treatment and control groups markedly improved the 24-hour albuminuria, total proteinuria (TPU), and urinary albumin to creatinine ratio (A/C) at 4, 8, and 12 weeks. Between treatment and the control group, the levels of albuminuria in the treatment group were significantly lower than in the control group at 8 and 12 weeks (p < 0.05). In addition, treatment group markedly decreased the scores of TCMS after treatment. Conclusion. This trial suggests that QDDHG combined with ARB administration decreases the levels of albuminuria and the scores for TCMS in normotensive individuals with T2DM.
authors.affiliation: School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, China; Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Xiang
authors.affiliation: School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, China; Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
authors.forename: Pingping
authors.initials: P
authors.lastname: Jiang
authors.affiliation: Endocrinology Department, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhou
authors.affiliation: School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, China.
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Sun
authors.affiliation: Second Chinese Medicine Hospital of Guangdong, Guangzhou, Guangdong 510095, China.
authors.forename: Jianlu
authors.initials: J
authors.lastname: Bi
authors.affiliation: First People's Hospital of Baiyun District, Guangzhou, Guangdong 510410, China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Cui
authors.affiliation: School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, China; Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Nie
authors.affiliation: School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, China; Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
authors.forename: Ren
authors.initials: R
authors.lastname: Luo
authors.affiliation: School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, China.
authors.forename: Xiaoshan
authors.identifier: 0000-0003-3081-0103
authors.initials: X
authors.lastname: Zhao
authors.affiliation: School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, China; Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Liu