title: T-bet and Eomesodermin in NK Cell Development, Maturation, and Function.
abstract: Recent reports give insights into the role of the T-box transcription factors, T-bet and Eomesodermin (Eomes), in NK cell biology. In this mini-review, we recapitulate the initial reports that delineate T-bet and Eomes as master regulators of NK cell development, maturation, and function. We discuss how T-bet and Eomes expression is regulated during NK cell development and peripheral maturation. Furthermore, we summarize the current literature on the role of T-bet and Eomes in the transcriptional regulation of NK cell function and review possible effects of T-box transcription factor anomalies during aging, infection, cancer, and after hematopoietic stem cell transplantation. We discuss how the current data argue in favor of a model of T-bet and Eomes synergy in transcriptional regulation of NK cell function and identify T-box transcription factors as potential targets for therapeutic interventions.
authors.affiliation: Department of Medical Specialties, Division of Hematology, Geneva University Hospitals, University of Geneva , Geneva , Switzerland.
authors.forename: Federico
authors.initials: F
authors.lastname: Simonetta
authors.affiliation: Department of Medical Specialties, Division of Hematology, Geneva University Hospitals, University of Geneva , Geneva , Switzerland.
authors.forename: Amandine
authors.initials: A
authors.lastname: Pradier
authors.affiliation: Department of Medical Specialties, Division of Hematology, Geneva University Hospitals, University of Geneva , Geneva , Switzerland.
authors.forename: Eddy
authors.initials: E
authors.lastname: Roosnek
keywords: Eomes; T-bet; T-box transcription factors; natural killer cells