title: Thiol/disulphide homeostasis in Bell's palsy as a novel pathogenetic marker.
abstract: OBJECTIVE
  The aim of this study was to investigate the relationship between Bell's palsy and a novel oxidative stress parameter, thiol/disulphide homeostasis.
  
  
  METHODS
  A prospective study evaluating oxidative stress in Bell's palsy.
  
  
  METHODS
  This research took place in the department of Otorhinolaryngology, Ataturk Training and Research Hospital.
  
  
  METHODS
  Totally, 77 patients with Bell's palsy and 38 healthy controls were included in this study.
  
  
  METHODS
  The blood levels of total and native thiol and disulphide activity were assessed, and their levels were compared in the patients and controls.
  
  
  RESULTS
  There were statistically significant differences between the patients and controls regarding thiol/disulphide parameters. The mean native thiol and total thiol were significantly lower and disulphide levels were higher in the Bell's palsy than controls. On binary logistic regression analysis, the created model showed 45.3% variation. The cut-off value was 18.95 for disulphides.
  
  
  CONCLUSIONS
  Native and total thiol levels were low in the Bell's palsy. This metabolic disturbance may have a role in the pathogenesis of Bell's palsy.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Yıldırım Beyazıt University School of Medicine, Ankara, Turkey.
authors.forename: M A
authors.initials: MA
authors.lastname: Babademez
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Bitlis Tatvan State Hospital, Bitlis, Turkey.
authors.forename: F
authors.initials: F
authors.lastname: Gul
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Ataturk Training and Research Hospital, Ankara, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Kale
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Ataturk Training and Research Hospital, Ankara, Turkey.
authors.forename: T
authors.initials: T
authors.lastname: Muderris
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Medipol University Faculty of Medicine, Istanbul, Turkey.
authors.forename: Y
authors.initials: Y
authors.lastname: Bayazit
authors.affiliation: Department of Clinical Biochemistry, Gaziantep 25 Aralık State Hospital, Gaziantep, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Ergin
authors.affiliation: Department of Clinical Biochemistry, Head and Neck Surgery, Yıldırım Beyazıt University School of Medicine, Ankara, Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Erel
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Yıldırım Beyazıt University School of Medicine, Ankara, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Kiris
mesh_terms: D000328:Adult; D020330:Bell Palsy / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D016022:Case-Control Studies; D004220:Disulfides / Q000378:metabolism*; D005260:Female; D006706:Homeostasis; D006801:Humans; D008297:Male; D018384:Oxidative Stress; D011446:Prospective Studies; D013438:Sulfhydryl Compounds / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D004220:Disulfides; D013438:Sulfhydryl Compounds