title: The changes in serum and whole blood rheological properties of rabbits during the progression of atherosclerosis.
abstract: This study aimed to evaluate the role of zinc (Zn)-supplemented with high cholesterol diet (HCD) on the serum and whole blood rheological properties of rabbits fed a HCD. Twenty-four New Zealand white rabbits were divided into three groups. The HCD group was fed a diet with 1.0% cholesterol and 1.0% olive oil. The HCD + Zn group was fed a diet with 1.0% cholesterol, 1.0% olive oil, and Zn. Blood viscosity, shear stress, and torque (%) were measured at shear rates ranging from 225 to 1875 s-1 for serum and 75-900 s-1 for whole blood. Serum viscosity and shear stress in HCD rabbits were significantly higher at all shear rates compared to controls; while whole blood viscosity and shear stress in HCD rabbits were significantly lower at all shear rates compared to controls. Viscosity and shear stress in both serum and whole blood from rabbits in the HCD + Zn group returned to normal values at all shear rates. The Zn supplemented to HCD rabbits, delays the progression of atherosclerosis. Changes in blood serum viscosity could reflect changes in non-clotting proteins, glucose, nutrients and trace elements; while changes in whole blood viscosity could result from changes in hematocrit, hemoglobin, and erythrocyte count. One of the factors responsible for increasing the serum viscosity values of HCD rabbits might be attributed to increase in Fe and decrease in Zn levels in the blood serum.
authors.affiliation: Department of Physics and Astronomy, College of Science, King Saud University, Saudi Arabia.
authors.forename: Mohamed Anwar
authors.initials: MA
authors.lastname: K Abdelhalim
authors.affiliation: Department of Physics and Astronomy, College of Science, King Saud University, Saudi Arabia.
authors.forename: Mohammed Suliman
authors.initials: MS
authors.lastname: Al-Ayed
authors.affiliation: Department of Physics, College of Science, Al-Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia / Biophysics Group, Biochemistry Dept., Genetic Engineering & Biotechnology, Division National Research Center, Dokki, Giza, Egypt.
authors.forename: Sherif A
authors.initials: SA
authors.lastname: Abdelmottaleb Moussa
authors.affiliation: Department of Physics and Astronomy, College of Science, King Saud University, Saudi Arabia.
authors.forename: Yanallah Hussain
authors.initials: YH
authors.lastname: Al-Mohy
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000097:blood / Q000503:physiopathology* / Q000517:prevention & control; D001809:Blood Viscosity; D002791:Cholesterol, Dietary; D059305:Diet, High-Fat; D019587:Dietary Supplements; D004195:Disease Models, Animal; D018450:Disease Progression; D018056:Hemorheology; D008297:Male; D011817:Rabbits; D013314:Stress, Mechanical; D013997:Time Factors; D015032:Zinc / Q000494:pharmacology
chemical_list: D002791:Cholesterol, Dietary; D015032:Zinc