title: Glucose-6-phosphate dehydrogenase a novel hope on a blood-based diagnosis of Alzheimer's disease.
abstract: Alzheimer's disease (AD) is a multi-factorial neurodegenerative disorder that numerous factors have key properties in the development of this proteopathy. Glucose-6-phosphate dehydrogenase (G6PD) is the most common form of enzymopathy. We have examined G6PD enzyme activity levels in the serum of newly diagnosed AD patients compared with control subjects without dementia from the both sexes. Serum G6PD levels were found to be significantly higher (approximately two times) in AD patients compared to control geriatric subjects in both sexes. We have concluded that G6PD seems to play an integral role in the progress and/or prevention of AD.
authors.affiliation: Department of Neurology, Faculty of Medicine, Çukurova University, Adana, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Evlice
authors.affiliation: Department of Biochemistry, School of Medicine, Koç University, Rumelifeneri Yolu, Sarıyer, Istanbul, Turkey. nulusu@ku.edu.tr.
authors.forename: Nuriye Nuray
authors.initials: NN
authors.lastname: Ulusu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood* / Q000175:diagnosis* / Q000201:enzymology*; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D005954:Glucosephosphate Dehydrogenase
keywords: Alzheimer’s disease; Biomarker; Glucose-6-phosphate dehydrogenase deficiency