title: Mitochondrial dynamics altered by oxidative stress in cancer.
abstract: Mitochondria as crucial organelles regulate cellular energy generation, calcium and redox homeostasis, and apoptosis. To perform the cellular functions effectively, mitochondria continuously change their structure and morphology through protein machineries controlling fission and fusion process (mitochondrial dynamics). Traditionally, many researches had focused on the interaction of mitochondrial dynamics and apoptosis. However, recent studies are reporting the alteration of mitochondrial dynamics in human diseases including many types of cancers. Considering that cancers maintain a high level of reactive oxygen species (ROS), mitochondrial dynamics can be influenced by oxidative stress. In this review, we will discuss the alteration of mitochondrial dynamics by ROS and its effect on metastasis and chemoresistance in cancers.
authors.affiliation: a Cancer Research Institute, College of Medicine , Seoul National University , Seoul , Korea.|b Nano System Institute, Seoul National University , Seoul , Korea.
authors.forename: Boyun
authors.initials: B
authors.lastname: Kim
authors.affiliation: a Cancer Research Institute, College of Medicine , Seoul National University , Seoul , Korea.|c WCU Biomodulation, Department of Agricultural Biotechnology , Seoul National University , Seoul , Korea.|d Department of Obstetrics and Gynecology, College of Medicine , Seoul National University , Seoul , Korea.
authors.forename: Yong Sang
authors.initials: YS
authors.lastname: Song
mesh_terms: D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D063154:Mitochondrial Dynamics; D009369:Neoplasms / Q000378:metabolism*; D018384:Oxidative Stress
keywords: Mitochondrial dynamics; cancer; chemoresistance; metastasis; reactive oxygen species