title: Asymmetric Transfer Hydrogenation of Imines using Alcohol: Efficiency and Selectivity are Influenced by the Hydrogen Donor.
abstract: The influence of the alcohol, as the hydrogen donor, on the efficiency and selectivity of the asymmetric transfer hydrogenation (ATH) of imines is reported for the first time. This discovery not only leads to a highly enantioselective access to N-aryl and N-alkyl amines, but also provides new insight into the mechanism of the ATH of imines. Both experimental and computational studies provide support for the reaction pathway involving an iridium alkoxide as the reducing species.
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543, Singapore.
authors.forename: Hui-Jie
authors.initials: HJ
authors.lastname: Pan
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543, Singapore.
authors.forename: Yao
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: School of Chemistry and Chemical Engineering, Chongqing University, Chongqing, 400030, P.R. China.
authors.forename: Chunhui
authors.initials: C
authors.lastname: Shan
authors.affiliation: School of Chemistry and Chemical Engineering, Chongqing University, Chongqing, 400030, P.R. China.
authors.forename: Zhaoyuan
authors.initials: Z
authors.lastname: Yu
authors.affiliation: School of Chemistry and Chemical Engineering, Chongqing University, Chongqing, 400030, P.R. China. lanyu@cqu.edu.cn.
authors.forename: Yu
authors.initials: Y
authors.lastname: Lan
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543, Singapore. zhaoyu@nus.edu.sg.
authors.forename: Yu
authors.identifier: 0000-0002-2944-1315
authors.initials: Y
authors.lastname: Zhao
keywords: amines; cooperative effects; enantioselectivity; hydrogenation; iridium