title: Eribulin Mesylate Combined with Local Treatment for Brain Metastasis from Breast Cancer: Two Case Reports.
abstract: The prognosis associated with brain metastasis arising from breast cancer is very poor. Eribulin is a microtubule dynamic inhibitor synthesized from halichondrin B, a natural marine product. In a phase III study (EMBRACE), eribulin improved overall survival in patients with heavily pretreated metastatic breast cancers. However, these studies included few patients with brain metastases. Metastatic brain tumors (MBT) were detected during first-line palliative chemotherapy in a 43-year-old woman with breast cancer metastasis to the lung and mediastinal nodes; the genetic subtype was luminal B-like human epidermal growth factor receptor 2 (HER2)-negative. Whole brain radiotherapy (WBRT) followed by eribulin treatment continuously decreased the size, and induced regression, of the MBT with systemic disease stability for 12 months. Another 48-year-old woman with metastatic breast cancer (HER2+ subtype) presented with MBT. Following surgical resection of the tumor, eribulin with concurrent WBRT showed regression of the MBT without systemic progression for 18 months.
authors.affiliation: Breast Center, Department of Surgery, Inje University Busan Paik Hospital, Busan, Korea.
authors.forename: Kyung-Do
authors.initials: KD
authors.lastname: Byun
authors.affiliation: Department of Surgery, Gangnam Medical Research Center, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Sung Gwe
authors.initials: SG
authors.lastname: Ahn
authors.affiliation: Breast Center, Department of Surgery, Inje University Busan Paik Hospital, Busan, Korea.
authors.forename: Hyung Joo
authors.initials: HJ
authors.lastname: Baik
authors.affiliation: Breast Center, Department of Surgery, Inje University Busan Paik Hospital, Busan, Korea.
authors.forename: Anbok
authors.initials: A
authors.lastname: Lee
authors.affiliation: Breast Center, Department of Surgery, Inje University Busan Paik Hospital, Busan, Korea.
authors.forename: Ki Beom
authors.initials: KB
authors.lastname: Bae
authors.affiliation: Breast Center, Department of Surgery, Inje University Busan Paik Hospital, Busan, Korea.
authors.forename: Min Sung
authors.initials: MS
authors.lastname: An
authors.affiliation: Breast Center, Department of Surgery, Inje University Busan Paik Hospital, Busan, Korea.
authors.forename: Kwang Hee
authors.initials: KH
authors.lastname: Kim
authors.affiliation: Breast Center, Department of Surgery, Inje University Busan Paik Hospital, Busan, Korea.
authors.forename: Jae Ho
authors.initials: JH
authors.lastname: Shin
authors.affiliation: Breast Center, Department of Surgery, Inje University Busan Paik Hospital, Busan, Korea.
authors.forename: Ha Kyoung
authors.initials: HK
authors.lastname: Park
authors.affiliation: Department of Radiation Oncology, Inje University Busan Paik Hospital, Busan, Korea.
authors.forename: Heunglae
authors.initials: H
authors.lastname: Cho
authors.affiliation: Department of Surgery, Gangnam Medical Research Center, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Joon
authors.initials: J
authors.lastname: Jeong
authors.affiliation: Breast Center, Department of Surgery, Inje University Busan Paik Hospital, Busan, Korea.
authors.forename: Tae Hyun
authors.initials: TH
authors.lastname: Kim
keywords: Brain; Breast neoplasms; Eribulin; Neoplasm metastasis