title: Lamina depth and thickness correlate with glaucoma severity.
abstract: OBJECTIVE
  To evaluate the correlation between lamina cribrosa (LC) morphology and glaucoma severity in patients with primary forms of open-angle glaucoma (OAG) using enhanced depth imaging spectral-domain optical coherence tomography (SD-OCT) and Humphrey visual field test (HVF).
  
  
  METHODS
  Patients with OAG (n = 166), divided into normal-tension glaucoma (NTG) and high-tension glaucoma (HTG) groups (n = 66 and n = 100), were imaged using SD-OCT to obtain horizontal B-scan images of the optic nerve head (ONH). Laminar depth (LD) and laminar thickness (LT) were measured at the center of ONH.
  
  
  RESULTS
  The mean (±standard deviation) values of LD, LT, and visual field mean deviation (MD) were 555.4 ± 142.3 μm, 179.9 ± 49.7 μm, and - 5.7 ± 6.4 dB, respectively. In the multivariate linear regression analysis, LD, LT, and intraocular pressure (IOP) were significantly correlated with MD (P = 0.007, P = 0.037, and P = 0.004, respectively). In the subgroup analyses, only LD was associated with MD in the NTG group (n = 66), whereas LT and IOP were correlated with MD in the HTG group (n = 100). Neither axial length nor central corneal thickness was associated with LD or LT.
  
  
  CONCLUSIONS
  Glaucoma severity, as measured by HVF MD, shows significant correlations with LD and LT, with greater severity associated with increasing LD and decreasing LT. Normal- and high-tension OAG patients have different associations with LD and LT, which implies that the pathogenesis of these two entities might be different.
authors.affiliation: Department of Ophthalmology, Dongguk University Ilsan Hospital, Goyang, Korea; Department of Ophthalmology, University of Washington, Seattle, WA, USA, .
authors.forename: Martha
authors.initials: M
authors.lastname: Kim
authors.affiliation: Department of Ophthalmology, University of Washington, Seattle, WA, USA.
authors.forename: Karine D
authors.initials: KD
authors.lastname: Bojikian
authors.affiliation: Department of Ophthalmology, University of Washington, Seattle, WA, USA.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Slabaugh
authors.affiliation: Department of Ophthalmology, University of Washington, Seattle, WA, USA.
authors.forename: Leona
authors.initials: L
authors.lastname: Ding
authors.affiliation: Department of Ophthalmology, University of Washington, Seattle, WA, USA.
authors.forename: Philip P
authors.initials: PP
authors.lastname: Chen
mesh_terms: D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D005901:Glaucoma / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D009898:Optic Disk / Q000473:pathology*; D011446:Prospective Studies; D012720:Severity of Illness Index; D041623:Tomography, Optical Coherence / Q000379:methods*; D058609:Visual Field Tests; D014794:Visual Fields