title: Is vaginal fractional CO2 laser treatment effective in improving overactive bladder symptoms in post-menopausal patients? Preliminary results.
abstract: To evaluate the role of vaginal fractional CO2 laser treatment in the relief of Overactive Bladder (OAB) symptoms in post-menopausal women.
  
  
  
  Post-menopausal women who complained of one or more symptoms related to vulvo-vaginal atrophy (VVA), who experienced symptoms of OAB and who underwent vaginal treatment with fractional CO2 laser were enrolled in the study. At baseline (T0) and 30 days post-treatment T1), vaginal status (using Vaginal Health Index - VHI), subjective intensity of VVA symptoms (using a visual analog scale - VAS) and micturition diary were evaluated. OAB symptoms were also assessed using a validated questionnaire.
  
  
  
  Thirty patients were enrolled. A statistically significant improvement in VVA symptoms was observed and in VHI at T1 (p < 0.0001). A significant improvement was also identified in the micturition diary, in number of urge episodes and OAB-q (p < 0.0001). Nine of the 30 patients suffered from incontinence episodes and had improved at T1.
  
  
  
  We showed that fractionated CO2 laser vaginal treatment has proved to be effective in improving OAB symptoms in post-menopausal women. Moreover, it is a safe and efficacious measure for the relief of VVA related conditions. Further long-term studies are needed to confirm these preliminary results.
authors.affiliation: Department of Science for Health Promotion and Mother and Child Care, Obstetrics and Gynecology Unit, University of Palermo, Palermo, Italy. gloria.calagna83@gmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Perino
authors.forename: G
authors.initials: G
authors.lastname: Cucinella
authors.forename: G
authors.initials: G
authors.lastname: Gugliotta
authors.forename: S
authors.initials: S
authors.lastname: Saitta
authors.forename: S
authors.initials: S
authors.lastname: Polito
authors.forename: B
authors.initials: B
authors.lastname: Adile
authors.forename: R
authors.initials: R
authors.lastname: Marci
authors.forename: G
authors.initials: G
authors.lastname: Calagna
mesh_terms: D000282:Administration, Intravaginal; D005260:Female; D006801:Humans; D054020:Lasers, Gas / Q000627:therapeutic use*; D017698:Postmenopause; D011788:Quality of Life; D016896:Treatment Outcome; D053201:Urinary Bladder, Overactive / Q000503:physiopathology / Q000523:psychology / Q000628:therapy*