title: Plasma total antioxidant capacity and peroxidation biomarkers in psoriasis.
abstract: Systemic biomarkers of oxidative stress can be relevant for assessment of psoriasis severity, for prediction of the outcome of therapy and of the development of comorbidities. In this review we aimed to evaluate the relationship between plasma total antioxidant capacity (TAC) and peroxidation biomarkers, as well as their association with dyslipidemia and systemic inflammation in psoriasis. The review of 59 case-control comparisons (from 41 studies) and 17 interventions (from 13 studies) suggests that peroxidation markers are more sensitive than TAC in the evaluation of oxidative stress in psoriasis. Although few studies investigated the effect of treatment on oxidative stress, it seems that biological drugs could be the better choice in the treatment of psoriasis. However, considering the limitations of TAC and plasma peroxidation markers, this review suggests that new methods should be developed in order to evaluate systemic oxidative stress in psoriasis.
authors.affiliation: Center of Nutrition, Council for Agricultural Research and Economics (CREA-NUT), Via Ardeatina 546, Rome, 00178, Italy. i.peluso@tiscali.it.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Peluso
authors.affiliation: Dermopathic Institute of the Immaculate IDI-IRCCS, Via dei Monti di Creta, 104, Rome, 00167, Italy.
authors.forename: Arturo
authors.initials: A
authors.lastname: Cavaliere
authors.affiliation: Department of Physiology and Pharmacology "V. Erspamer", "Sapienza" University of Rome, P.le Aldo Moro 5, Rome, 00185, Italy.
authors.forename: Maura
authors.initials: M
authors.lastname: Palmery
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D006801:Humans; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D011565:Psoriasis / Q000097:blood*
chemical_list: D000975:Antioxidants; D015415:Biomarkers
keywords: Human studies; Peroxidation biomarkers; Psoriasis; Total antioxidant capacity