title: Single-Centre 20-Year Experience with Surgical Treatment of Thymic Tumours.
abstract: BACKGROUND
  Large single-centre institutional series on thymic tumours are rare. Complete resection remains the mainstay of successful treatment. Characteristics and survival were reviewed in all patients treated between 19932013.
  
  
  METHODS
  Hospital databases revealed 134 patients with pathologically-proven thymic tumour. Follow-up (median 63 months) was through patient notes and telephone contact with general practitioner.
  
  
  RESULTS
  Patients were classified in Masaoka-Koga stages: I: 50 (37%); Ila: 14 (10%); lib: 14 (10%); III: 27 (20%); IVa: 19 (14%); IVb: 4 (3%); unknown: 6 (5%). According to WHO classification, pathological subtypes were A: 19 (14%); AB: 25 (19%); B1: 21 (16%); B2: 31 (23%); B3: 15 (11%); thymic carcinoma: 23 (17%). Parathymic syndromes were diagnosed in 45 patients: myasthenia gravis (84%); pure red-cell aplasia (4%); hypogammaglobulinemia (2%); and others. 124 patients (93%) underwent surgery with complete resection in 104 (84%). Surgical approach was: sternotomy: 79; thoracotomy: 35; cervicotomy: 2; other/unknown: 8. In 73 patients (59%) no biopsy was taken prior to surgical resection, 25 were treated with induction chemotherapy, 36 received adjuvant radiotherapy. Hospital mortality was 0.81%. 35 patients died during follow-up (13 of tumour or treatment-related causes). Overall and recurrence-free survival at 5, 10, and 15 years were 86%; 64%; 47% and 67%; 49%; and 31%, respectively and were significantly (p < 0.01) different according to Masaoka-Koga stage. There was a significant association between WHO classification and Masaoka-Koga stages I-IIa-IIb versus III-IVa-IVb (p < 0.01).
  
  
  CONCLUSIONS
  Operability and complete resectability of thymic tumours in our experience is high resulting in prolonged overall and recurrence-free survival. Masaoka-Koga stage is an important predictor for survival and shows a significant association with WHO classification.
authors.affiliation: a Departments of Thoracic Surgery , Belgium.
authors.forename: S
authors.initials: S
authors.lastname: Viskens
authors.affiliation: a Departments of Thoracic Surgery , Belgium.
authors.forename: H
authors.initials: H
authors.lastname: Van Veer
authors.affiliation: b Departments of Pathology , Belgium.
authors.forename: T
authors.initials: T
authors.lastname: Tousseyn
authors.affiliation: a Departments of Thoracic Surgery , Belgium.
authors.forename: W
authors.initials: W
authors.lastname: Coosemans
authors.affiliation: a Departments of Thoracic Surgery , Belgium.
authors.forename: H
authors.initials: H
authors.lastname: Decaluwe
authors.affiliation: a Departments of Thoracic Surgery , Belgium.
authors.forename: Ph
authors.initials: P
authors.lastname: Nafteux
authors.affiliation: a Departments of Thoracic Surgery , Belgium.
authors.forename: P
authors.initials: P
authors.lastname: De Leyn
authors.affiliation: c Departments of Medical Oncology , Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Schojfskf
authors.affiliation: d Departments of Radiation Oncology. University Hospitals Leuven , Belgium.
authors.forename: D
authors.initials: D
authors.lastname: De Ruysscher
authors.affiliation: a Departments of Thoracic Surgery , Belgium.
authors.forename: D
authors.initials: D
authors.lastname: Van Raemdonck
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016208:Databases, Factual; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006785:Hospitals, University; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000401:mortality* / Q000503:physiopathology; D009367:Neoplasm Staging; D012189:Retrospective Studies; D018570:Risk Assessment; D015996:Survival Rate; D013934:Thymectomy / Q000379:methods*; D013953:Thymus Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult