title: SXR rs3842689: a prognostic factor for steroid sensitivity or resistance in pediatric idiopathic nephrotic syndrome.
abstract: of the study was to analyse the impact of SXR rs3842689 polymorphism on the response to corticosteroids in pediatric idiopathic nephrotic syndrome.
  
  
  
  66 children (56 steroid-sensitive, ten steroid-resistant) were studied for SXR gene polymorphism distribution.
  
  
  
  Steroid sensitive patients accounted for 96% of cases with In/In polymorphism, but only for 53% of cases with Del/Del polymorphism At odds ratio analysis, Del/Del represented a clear risk factor of steroid resistance (OR: 20.57; p = 0.009), while In/In was a favourable prognostic factor of steroid sensitivity.
  
  
  
  The analysis of SXR polymorphism is a promising tool to predict both the favourable response to corticosteroids and the risk of developing steroid resistance.
authors.affiliation: Pediatric Nephrology & Dialysis, Milano. Fondazione IRCCS Cà Grande Ospedale Maggiroe Policlinico, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Turolo
authors.affiliation: Pediatric Nephrology & Dialysis, Milano. Fondazione IRCCS Cà Grande Ospedale Maggiroe Policlinico, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Edefonti
authors.affiliation: Pediatric Nephrology & Dialysis, Milano. Fondazione IRCCS Cà Grande Ospedale Maggiroe Policlinico, Italy.
authors.forename: Marta
authors.initials: M
authors.lastname: Lepore
authors.affiliation: Pediatric Nephrology & Dialysis, Milano. Fondazione IRCCS Cà Grande Ospedale Maggiroe Policlinico, Italy.
authors.forename: Luciana
authors.initials: L
authors.lastname: Ghio
authors.affiliation: Università degli Studi di Trieste Dipartimento di Scienze della Vita, Trieste, Friuli-Venezia Giulia, Italy.
authors.forename: Eva
authors.initials: E
authors.lastname: Cuzzoni
authors.affiliation: Università degli Studi di Trieste Dipartimento di Scienze della Vita, Trieste, Friuli-Venezia Giulia, Italy.
authors.forename: Giuliana
authors.initials: G
authors.lastname: Decorti
authors.affiliation: Università degli Studi di Bologna Azienda Ospedaliera Sant/'Orsola-Malpighi, Bologna, Emilia-Romagna, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Pasini
authors.affiliation: Ospedale Pediatrico Meyer Firenze, Toscana, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Materassi
authors.affiliation: Università degli Studi di Ferrara, Medical Science Ferrara, Emilia-Romagna, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Malaventura
authors.affiliation: Agenzia sanitaria e sociale regionale Regione Emilia-Romagna, Ravenna, Emilia-Romagna, Italy.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Pugliese
authors.affiliation: Pediatric Nephrology & Dialysis, Milano. Fondazione IRCCS Cà Grande Ospedale Maggiroe Policlinico, Italy.|Università degli Studi di Milano, Department of Clinical Sciences and Community Health, Milan, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Montini
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004351:Drug Resistance / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D009404:Nephrotic Syndrome / Q000188:drug therapy* / Q000235:genetics*; D050862:Oxidoreductases Acting on Sulfur Group Donors / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors
chemical_list: D000305:Adrenal Cortex Hormones; D050862:Oxidoreductases Acting on Sulfur Group Donors; C504024:SRXN1 protein, human
keywords: SXR; idiopathic nephrotic syndrome; steroid-resistant; steroids