title: Chronic Kidney Disease As a Potential Indication for Renal Denervation.
abstract: Renal denervation is being used as a blood pressure lowering therapy for patients with apparent treatment resistant hypertension. However, this population does not represent a distinct disease condition in which benefit is predictable. In fact, the wide range in effectiveness of renal denervation could be a consequence of this heterogeneous pathogenesis of hypertension. Since renal denervation aims at disrupting sympathetic nerves surrounding the renal arteries, it seems obvious to focus on patients with increased afferent and/or efferent renal sympathetic nerve activity. In this review will be argued, from both a pathophysiological and a clinical point of view, that chronic kidney disease is particularly suited to renal denervation.
authors.affiliation: Department of Nephrology and Hypertension, University Medical Centre Utrecht Utrecht, Netherlands.
authors.forename: Margreet F
authors.initials: MF
authors.lastname: Sanders
authors.affiliation: Department of Nephrology and Hypertension, University Medical Centre Utrecht Utrecht, Netherlands.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Blankestijn
keywords: chronic kidney disease; hypertension; renal denervation; renin-angiotensin-aldosterone-system; sympathetic nervous system