title: The immune microenvironment in Hodgkin lymphoma: T cells, B cells, and immune checkpoints.
abstract: Classical Hodgkin lymphoma is curable in the majority of cases with chemotherapy and/or radiation. However, 15-20% of patients ultimately relapse and succumb to their disease. Pathologically, classical Hodgkin lymphoma is characterized by rare tumor-initiating Reed-Sternberg cells surrounded by a dense immune microenvironment. However, the role of the immune microenvironment, particularly T and B cells, in either promoting or restricting Classical Hodgkin lymphoma growth remains undefined. Recent dramatic clinical responses seen using monoclonal antibodies against PD-1, a cell surface receptor whose primary function is to restrict T cell activation, have reignited questions regarding the function of the adaptive immune system in classical Hodgkin lymphoma. This review summarizes what is known regarding T cells, B cells, and immune checkpoints in classical Hodgkin lymphoma.
authors.affiliation: Lymphoma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
authors.forename: Santosha
authors.initials: S
authors.lastname: Vardhana
authors.affiliation: Lymphoma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA younesa@mskcc.org.
authors.forename: Anas
authors.initials: A
authors.lastname: Younes
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism*; D015415:Biomarkers; D003131:Combined Modality Therapy; D006689:Hodgkin Disease / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D056747:Immunomodulation / Q000187:drug effects; D007167:Immunotherapy; D058990:Molecular Targeted Therapy; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism*; D059016:Tumor Microenvironment / Q000187:drug effects / Q000276:immunology*
chemical_list: D000970:Antineoplastic Agents; D015415:Biomarkers