title: Detailed description of a prepregnancy care program and its impact on maternal glucose control, weight gain, and dropouts.
abstract: The aim of this study was to analyze the clinical and metabolic changes observed during a prepregnancy care (PPC) program.
  
  
  
  We performed a retrospective, observational, cohort study of 104 women with type 1 diabetes initiating a PPC program from 2011 to 2014. The outcomes measured were changes in HbA1clevels, weight and hypoglycemic events during PPC. Risk factors associated with severe hypoglycemia events, achieving the HbA1ctarget and dropouts were evaluated.
  
  
  
  HbA1cdecreased from 7.2 ± 0.8% (55.3 ± 8.8 mmol/mol) to 6.7 ± 0.9% (49.8 ± 10.3 mmol/mol) (P < .001) within a median of 14.2 months (interquartile interval 5.4-23.2); 71.2% obtained HbA1c< 7% (53 mmol/mol). HbA1cat the end of PPC was associated with baseline HbA1c(β = .318, P = .001) and the number of previous pregnancies (β = .224, P = .038), PPC was accompanied by 1.4 ± 4.0 kg weight gain (P = .003) without changes in severe hypoglycemic events. The risk factors for severe hypoglycemia were severe hypoglycemic events during the 2 years before (odds ratio [OR] 11.99, confidence interval 95% 1.89-75.95) and PPC duration (OR 1.09, 1.03-1.16). A total of 33 patients (31.7%) dropped out from PPC during follow-up, with dropout being associated with age (OR 1.17, 1.04-1.36) and PPC duration (OR 1.06, 1.02-1.11).
  
  
  
  Our PPC program was associated with an improvement in glycemic control without a significant increase in severe hypoglycemic events, although with some weight gain. A considerable number of patients dropped out during follow-up, this being related to older age and a longer duration of the program. This information could be of help to design new and more effective PPC approaches. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Diabetes Unit, Endocrinology and Nutrition Service, Hospital Clínic i Universitari de Barcelona, Barcelona, Spain.|Endocrinology and Nutrition Service, Hospital Universitari Mútua de Terrassa, Terrassa, Spain.
authors.forename: Verónica
authors.initials: V
authors.lastname: Perea
authors.affiliation: Diabetes Unit, Endocrinology and Nutrition Service, Hospital Clínic i Universitari de Barcelona, Barcelona, Spain.
authors.forename: Aida
authors.initials: A
authors.lastname: Orois
authors.affiliation: Diabetes Unit, Endocrinology and Nutrition Service, Hospital Clínic i Universitari de Barcelona, Barcelona, Spain.
authors.forename: Antonio J
authors.initials: AJ
authors.lastname: Amor
authors.affiliation: Diabetes Unit, Endocrinology and Nutrition Service, Hospital Clínic i Universitari de Barcelona, Barcelona, Spain.
authors.forename: Marga
authors.initials: M
authors.lastname: Jansà
authors.affiliation: Diabetes Unit, Endocrinology and Nutrition Service, Hospital Clínic i Universitari de Barcelona, Barcelona, Spain.
authors.forename: Merce
authors.initials: M
authors.lastname: Vidal
authors.affiliation: Diabetes Unit, Endocrinology and Nutrition Service, Hospital Clínic i Universitari de Barcelona, Barcelona, Spain.
authors.forename: Marga
authors.initials: M
authors.lastname: Gimenez
authors.affiliation: Diabetes Unit, Endocrinology and Nutrition Service, Hospital Clínic i Universitari de Barcelona, Barcelona, Spain.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Conget
authors.affiliation: Diabetes Unit, Endocrinology and Nutrition Service, Hospital Clínic i Universitari de Barcelona, Barcelona, Spain.
authors.forename: Irene
authors.initials: I
authors.lastname: Vinagre
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000517:prevention & control*; D005260:Female; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology / Q000517:prevention & control*; D007003:Hypoglycemia / Q000209:etiology / Q000517:prevention & control*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011254:Pregnancy in Diabetics / Q000503:physiopathology*; D011295:Prenatal Care; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D015430:Weight Gain
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; C517652:hemoglobin A1c protein, human
keywords: hypoglycemia; prepregnancy care; type 1 diabetes mellitus; weight gain