title: Is osseointegration inflammation-triggered?
abstract: Bioinert endosteal implants cause a foreign body reaction, whereas bioactive ones cause osseointegration. However, the mechanisms responsible for the two modi of host response remain unclear. COX-2(-/-) animal models showed the dependence of osseointegration on prostaglandins. PGE2, a product of COX-2, augments Wnt signalling, a pathway that promotes the regeneration in many types of tissues. Recently, we demonstrated the ability of bioactive implants to recruit neutrophils and to trigger neutrophil extracellular traps (NETs), which are a potent source of PGE2. In bioinert implants no PGE2 release has been ascertained. Collectively, these findings suggest that osseointegration might be the host response to bioactive implants, novel and quite different to the so-called foreign body reaction.
authors.affiliation: Department of Zoological Structure Research, Cell Biology, University of Salzburg, Salzburg, Austria; Clinic of Operative Dentistry, Periodontology and Preventive Dentistry, Saarland University, Homburg, Germany. Electronic address: lvitkov@yahoo.com.
authors.forename: Ljubomir
authors.initials: L
authors.lastname: Vitkov
authors.affiliation: Children's Hospital and Interdisciplinary Center for Infectious Diseases, University of Tuebingen, Tuebingen, Germany.
authors.forename: Dominik
authors.initials: D
authors.lastname: Hartl
authors.affiliation: Clinic of Operative Dentistry, Periodontology and Preventive Dentistry, Saarland University, Homburg, Germany. Electronic address: matthias.hannig@uks.eu.
authors.forename: Matthias
authors.initials: M
authors.lastname: Hannig
mesh_terms: D000818:Animals; D051546:Cyclooxygenase 2 / Q000235:genetics; D015232:Dinoprostone / Q000378:metabolism; D065206:Extracellular Traps; D005312:Fetal Blood / Q000166:cytology; D005549:Foreign-Body Reaction; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D020780:Matrix Metalloproteinase 9 / Q000235:genetics; D051379:Mice; D018345:Mice, Knockout; D023421:Models, Animal; D008962:Models, Theoretical; D018919:Neovascularization, Physiologic; D016348:Osseointegration; D060449:Wnt Signaling Pathway
chemical_list: C077623:Ptgs2 protein, mouse; D051546:Cyclooxygenase 2; D020780:Matrix Metalloproteinase 9; C501830:Mmp9 protein, mouse; D015232:Dinoprostone
keywords: Angiogenesis; COX-2; Implant; Inflammatory response; MMP-9; PGE2; Regeneration