title: Filamentous influenza viruses.
abstract: Clinical isolates of influenza virus produce pleomorphic virus particles, including extremely long filamentous virions. In contrast, strains of influenza that have adapted to laboratory growth typically produce only spherical virions. As a result, the filamentous phenotype has been overlooked in most influenza virus research. Recent advances in imaging and improved animal models have highlighted the distinct structure and functional relevance of filamentous virions. In this review we summarize what is currently known about these strikingly elongated virus particles and discuss their possible roles in clinical infections.
authors.affiliation: Sir William Dunn School of Pathology, University of Oxford, South Parks Rd, Oxford OX1 3RE, UK.
authors.forename: Bernadeta
authors.initials: B
authors.lastname: Dadonaite
authors.affiliation: MRC-University of Glasgow Centre for Virus Research, University of Glasgow, 464 Bearsden Rd, Bearsden, Glasgow, Lanarkshire G61 1QH, UK.
authors.forename: Swetha
authors.initials: S
authors.lastname: Vijayakrishnan
authors.affiliation: Sir William Dunn School of Pathology, University of Oxford, South Parks Rd, Oxford OX1 3RE, UK.
authors.forename: Ervin
authors.initials: E
authors.lastname: Fodor
authors.affiliation: MRC-University of Glasgow Centre for Virus Research, University of Glasgow, 464 Bearsden Rd, Bearsden, Glasgow, Lanarkshire G61 1QH, UK.
authors.forename: David
authors.initials: D
authors.lastname: Bhella
authors.affiliation: MRC-University of Glasgow Centre for Virus Research, University of Glasgow, 464 Bearsden Rd, Bearsden, Glasgow, Lanarkshire G61 1QH, UK.|Sir William Dunn School of Pathology, University of Oxford, South Parks Rd, Oxford OX1 3RE, UK.
authors.forename: Edward C
authors.initials: EC
authors.lastname: Hutchinson
mesh_terms: D000818:Animals; D006801:Humans; D009975:Orthomyxoviridae / Q000502:physiology* / Q000648:ultrastructure*; D019065:Virus Assembly