title: Iriomoteolides-10a and 12a, Cytotoxic Macrolides from Marine Dinoflagellate Amphidinium Species.
abstract: Two new macrolides, iriomoteolides-10a (1) and -12a (2), have been isolated from a marine dinoflagellate Amphidinium sp. (KCA09053 strain), and their structures were elucidated on the basis of a detailed two dimensional (2D)-NMR analysis. Compound 1 is a novel 21-membered Amphidinium macrolide, which contains one tetrahydrofuran ring, two ketone carbonyls, two hydroxyl groups, and six one-carbon branches. Compound 2 is a new 12-membered macrolide related to amphidinolide Q. Compound 1 exhibited cytotoxic activity against human cervix adenocarcinoma HeLa and murine hepatocellular carcinoma MH134 cells.
authors.affiliation: Science Research Center, Kochi University.
authors.forename: Mai
authors.initials: M
authors.lastname: Akakabe
authors.forename: Keiko
authors.initials: K
authors.lastname: Kumagai
authors.forename: Masayuki
authors.initials: M
authors.lastname: Tsuda
authors.forename: Yuko
authors.initials: Y
authors.lastname: Konishi
authors.forename: Akira
authors.initials: A
authors.lastname: Tominaga
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kaneno
authors.forename: Eri
authors.initials: E
authors.lastname: Fukushi
authors.forename: Jun
authors.initials: J
authors.lastname: Kawabata
authors.forename: Atsunori
authors.initials: A
authors.lastname: Masuda
authors.forename: Masashi
authors.initials: M
authors.lastname: Tsuda
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004141:Dinoflagellida / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D006367:HeLa Cells; D006801:Humans; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D008968:Molecular Conformation; D013329:Structure-Activity Relationship
chemical_list: D018942:Macrolides; C000613669:iriomoteolide-10a; C000613670:iriomoteolide-12a