title: Increased neutrophil-to-lymphocyte ratio is associated with disease-specific mortality in patients with penile cancer.
abstract: The neutrophil-to-lymphocyte ratio (NLR), a simple marker of the systemic inflammatory response, has been demonstrated to correlate with patient outcomes for various solid malignancies. We investigated the utility of the pretreatment NLR as a prognosticator in patients who presented with penile cancer.
  
  
  
  A total of 41 patients who underwent complete blood count with differential and subsequent radical penectomy from 1988 to 2014 were analyzed. We assessed the correlation between the NLR and the prognosis of penile cancer.
  
  
  
  The median and mean (± SD) NLRs in 41 penile cancer patients were 3.42 and 5.03 ± 4.99, respectively. Based on the area under receiver operator characteristic curve, the cut-off value of NLR was determined to be 2.82. Patients with a high NLR (≥2.82) showed a significantly poorer cancer-specific survival (p = 0.023) than those with a low NLR.
  
  
  
  The pretreatment NLR may function as a biomarker that precisely predicts the prognosis in patients with penile cancer.
authors.affiliation: Department of Urology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 2360004, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Kasuga
authors.affiliation: Department of Urology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 2360004, Japan. takashi_tk2001@yahoo.co.jp.|Departments of Urology and Renal transplantation, Yokohama City University Medical Center, Yokohama, Japan. takashi_tk2001@yahoo.co.jp.
authors.forename: Takashi
authors.identifier: 0000-0002-7049-3379
authors.initials: T
authors.lastname: Kawahara
authors.affiliation: Department of Urology, Yokohama Minami Kyosai Hospital, Yokohama, Japan.
authors.forename: Daiji
authors.initials: D
authors.lastname: Takamoto
authors.affiliation: Department of Urology, Yokohama Minato Red Cross Hospital, Yokohama, Japan.
authors.forename: Sachi
authors.initials: S
authors.lastname: Fukui
authors.affiliation: Department of Urology, Yokosuka Kyosai Hospital, Yokosuka, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Tokita
authors.affiliation: Department of Urology, Kanagawa Cancer Center, Yokohama, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Tadenuma
authors.affiliation: Department of Urology, International Goodwill Hospital, Yokohama, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Narahara
authors.affiliation: Department of Urology, Yamato Municipal Hospital, Yamato, Japan.
authors.forename: Syusei
authors.initials: S
authors.lastname: Fusayasu
authors.affiliation: Department of Urology, Fujisawa City Hospital, Fujisawa, Japan.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Terao
authors.affiliation: Department of Urology, Yokohama Municipal Citizen's Hospital, Yokohama, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Izumi
authors.affiliation: Department of Urology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 2360004, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ito
authors.affiliation: Departments of Urology and Renal transplantation, Yokohama City University Medical Center, Yokohama, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Hattori
authors.affiliation: Departments of Urology and Renal transplantation, Yokohama City University Medical Center, Yokohama, Japan.
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Teranishi
authors.affiliation: Department of Pathology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sasaki
authors.affiliation: Department of Urology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 2360004, Japan.
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Makiyama
authors.affiliation: Departments of Urology and Renal transplantation, Yokohama City University Medical Center, Yokohama, Japan.
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Miyoshi
authors.affiliation: Department of Urology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 2360004, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yao
authors.affiliation: Departments of Urology and Renal transplantation, Yokohama City University Medical Center, Yokohama, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Yumura
authors.affiliation: Departments of Pathology and Urology, Johns Hopkins University School of Medicine, Baltimore, USA.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Miyamoto
authors.affiliation: Departments of Urology and Renal transplantation, Yokohama City University Medical Center, Yokohama, Japan.
authors.forename: Hiroji
authors.initials: H
authors.lastname: Uemura
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D002294:Carcinoma, Squamous Cell / Q000401:mortality* / Q000473:pathology; D006801:Humans; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009504:Neutrophils / Q000166:cytology*; D010412:Penile Neoplasms / Q000401:mortality* / Q000473:pathology; D011379:Prognosis; D012372:ROC Curve; D016019:Survival Analysis
keywords: Biomarker; Immunohistochemistry; Neutrophil-to-lymphocyte ratio; Penile cancer