title: Neuroprotective Effectiveness of Intravenous Ubiquinone in Rat Model of Irreversible Cerebral Ischemia.
abstract: The neuroprotective effect of ubiquinone (coenzyme Q10)was demonstrated on the rats model of ischemic stroke provoked by persistent 24-h occlusion of the middle cerebral artery. Coenzyme Q10 (30 mg/kg) was injected intravenously in 60 min after artery occlusion. Ubiquinone crossed the blood-brain barrier, accumulated in the brain, and produced a neuroprotective effect: it alleviated ischemia-induced neurological deficit and reduced the size of necrotic zone by 49% in comparison with rats receiving physiological saline.
authors.affiliation: Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia. margarita.a.belousova@gmail.com.
authors.forename: M A
authors.initials: MA
authors.lastname: Belousova
authors.affiliation: Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia.
authors.forename: O G
authors.initials: OG
authors.lastname: Tokareva
authors.affiliation: Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Gorodetskaya
authors.affiliation: Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia.
authors.forename: E I
authors.initials: EI
authors.lastname: Kalenikova
authors.affiliation: Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia.
authors.forename: O S
authors.initials: OS
authors.lastname: Medvedev
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D016166:Free Radical Scavengers / Q000008:administration & dosage*; D020244:Infarction, Middle Cerebral Artery / Q000188:drug therapy*; D007275:Injections, Intravenous; D008297:Male; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D017208:Rats, Wistar; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D016166:Free Radical Scavengers; D018696:Neuroprotective Agents; D014451:Ubiquinone; C024989:coenzyme Q10
keywords: antioxidant; coenzyme Q 10 (ubiquinone); ischemic stroke; neuroprotection