title: Adiponectin and resistin in acute and chronic graft-vs-host disease patients undergoing allogeneic hematopoietic stem cell transplantation.
abstract: OBJECTIVE
  To investigate the association of adiponectin and resistin levels in patients undergoing hematopoietic stem cell transplantation (HSCT) with the clinical outcome, including the occurrence of acute and chronic graft-vs-host disease (GVHD), non-relapse mortality, and overall survival.
  
  
  METHODS
  We prospectively collected serum samples from 40 patients undergoing either autologous (n=12; 10 male) or allogeneic (n=28; 11 male) HSCT for up to 12 months post HSCT and determined adiponectin and resistin serum concentrations using enzyme-linked immunosorbent assay.
  
  
  RESULTS
  There were no significant differences in adiponectin levels (18.5 vs 9.3 μg/mL, P=0.071) and adiponectin/BMI ratio (0.82 vs 0.39, P=0.068) between patients with acute GVHD grades 2-4 and autologous controls. However, resistin values were significantly lower in patients with acute GVHD grades 2-4 than in autologous controls (4.6 vs 7.3 ng/mL, P=0.030). Adiponectin levels were higher in patients with chronic GVHD (n=17) than in autologous controls (13.5 vs 7.6 μg/mL, P=0.051), but the difference was not significant. Adiponectin/BMI ratio was significantly higher in patients with chronic GVHD than in autologous controls (0.59 vs 0.25, P=0.006). Patients dying from relapse also had significantly lower adiponectin levels (8.2 μg/mL) and adiponectin/BMI ratio (0.3) on admission than surviving allogeneic (15.8 µg/mL, P=0.030 and 0.7, P=0.004) and surviving autologous patients (19.2 μg/mL, P=0.031 and 0.7, P=0.021).
  
  
  CONCLUSIONS
  Adiponectin and resistin levels were altered in patients with acute and chronic GVHD compared to autologous controls and were associated with overall survival and relapse mortality in patients undergoing allogeneic HSCT.
authors.affiliation: Oliver Robak, Department of Internal Medicine I, Intensive Care Unit, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria, oliver.robak@meduniwien.ac.at.
authors.forename: Oliver
authors.initials: O
authors.lastname: Robak
authors.forename: Zoya
authors.initials: Z
authors.lastname: Kuzmina
authors.forename: Andreas
authors.initials: A
authors.lastname: Winkler
authors.forename: Peter
authors.initials: P
authors.lastname: Kalhs
authors.forename: Werner
authors.initials: W
authors.lastname: Rabitsch
authors.forename: Hildegard
authors.initials: H
authors.lastname: Greinix
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D001317:Austria; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006086:Graft vs Host Disease / Q000097:blood* / Q000401:mortality / Q000473:pathology; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012008:Recurrence; D052243:Resistin / Q000097:blood*; D012720:Severity of Illness Index; D016019:Survival Analysis
chemical_list: D052242:Adiponectin; D052243:Resistin