title: Clinical and neuroimaging differences between posterior cortical atrophy and typical amnestic Alzheimer's disease patients at an early disease stage.
abstract: To identify clinical and neuroimaging characteristics between posterior cortical atrophy (PCA) and typical amnestic Alzheimer's disease (tAD) patients at an early disease stage, 16 PCA and 13 age-matched tAD patients were enrolled. Compared with tAD patients, PCA patients showed higher mean recognition and recall test scores, and lower mean calculation, spatial attention, shape discrimination, and writing test scores. Mean right hippocampal volume was larger in PCA patients compared with tAD patients, while cortical gray matter (GM) volume of bilateral parietal and occipital lobes was smaller in PCA patients. Further, when compared with tAD patients, significant hypometabolism was observed in bilateral parietal and occipital lobes, particularly the right occipitotemporal junction in PCA patients. Additionally, there were significant positive correlations in recognition and recall scores with hippocampal volumes. In PCA patients, calculation and visuospatial ability scores are positively associated with GM volume of parietal and occipital lobes. And only spatial attention and shape discrimination scores are positively associated with regional glucose metabolism of parietal and occipital lobes. Therefore, PCA patients display better recognition and recall scores, which are associated with larger hippocampal volumes and poorer performance in visual spatial tasks because of marked GM atrophy and hypometabolism of parietal and occipital lobes.
authors.affiliation: Department of Neurology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.|Laboratory of Brain Medical Center, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Guoping
authors.initials: G
authors.lastname: Peng
authors.affiliation: Department of Neurology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Jianqin
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Radiology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Zhan
authors.initials: Z
authors.lastname: Feng
authors.affiliation: Department of Neurology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
authors.affiliation: Department of PET Center, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Yafei
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Laboratory of Brain Medical Center, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Fangping
authors.initials: F
authors.lastname: He
authors.affiliation: Department of Neurology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Zhongqin
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of PET Center, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Kui
authors.initials: K
authors.lastname: Zhao
authors.affiliation: Department of Neurology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.|Laboratory of Brain Medical Center, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Benyan
authors.initials: B
authors.lastname: Luo
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000523:psychology*; D053327:Apolipoprotein E4 / Q000378:metabolism; D001284:Atrophy; D002540:Cerebral Cortex / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D066128:Gray Matter / Q000000981:diagnostic imaging / Q000473:pathology; D006624:Hippocampus / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D059906:Neuroimaging / Q000379:methods*; D021641:Recognition, Psychology; D065854:Spatial Navigation
chemical_list: D053327:Apolipoprotein E4