title: [Not Available].
abstract: Posaconazole, systemic antifungal marketed in France since 2006, is indicated as second line in curative treatment of invasive fungal infections (IFI) (aspergillosis. . . ) and prophylaxis of IFI in patients receiving chemotherapy or hematopoietic stem cell transplantation. The analysis of the literature indicates a concentration-efficacy relationship, but to date, no study has been able to show a concentration-toxicity correlation due to its favourable safety profile and the difficulty to obtain high concentrations. In curative, maintenance of trough plasma concentrations between 0.5 and 1.5 mg/L seems to be associate with an efficacy. In prophylaxis, a threshold of 0.5 mg/L corresponds to a minimal exposure. However this target is not yet well defined. Saturation of absorption above the 800 mg oral dose limits the adjustment of concentrations. As such, the Therapeutic Drug Monitoring of posaconazole can be recommended.
authors.affiliation: Laboratoire de Pharmacologie-Toxicologie, Assistance Publique-Hôpitaux de Paris, Hôpital EuropéenGeorgesPompidou, Paris, France; Université Paris Descartes, Paris, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Lefeuvre
authors.affiliation: Laboratoire de Pharmacologie-Toxicologie, Assistance Publique-Hôpitaux de Paris, Hôpital EuropéenGeorgesPompidou, Paris, France.
authors.forename: Mohammed-Larbi
authors.initials: ML
authors.lastname: Jelassi
authors.affiliation: Laboratoire de Pharmacologie-Toxicologie, Assistance Publique-Hôpitaux de Paris, Hôpital EuropéenGeorgesPompidou, Paris, France.
authors.forename: Amine
authors.initials: A
authors.lastname: Benlmouden
authors.affiliation: Laboratoire de Pharmacologie-Toxicologie, Assistance Publique-Hôpitaux de Paris, Hôpital EuropéenGeorgesPompidou, Paris, France; Université Paris Descartes, Paris, France.
authors.forename: Maud
authors.initials: M
authors.lastname: Berge
authors.affiliation: Université François Rabelais de Tours, CHRU de Tours, Tours, France.
authors.forename: Chantal
authors.initials: C
authors.lastname: Le Guellec
authors.affiliation: Laboratoire de Pharmacologie-Toxicologie, Assistance Publique-Hôpitaux de Paris, Hôpital EuropéenGeorgesPompidou, Paris, France; Université Paris Descartes, Paris, France. Electronic address: eliane.billaud@egp.aphp.fr.
authors.forename: Eliane M
authors.initials: EM
authors.lastname: Billaud
keywords: posaconazole; suivi thérapeutique pharmacologique; therapeutic drug monitoring