title: Obstetric and perinatal outcomes in women ≥40years of age: Associations with fetal growth disorders.
abstract: Evidence indicates that advanced maternal age is associated with adverse obstetric and perinatal outcomes. The purpose of this study was to evaluate pregnancy outcomes in women of advanced maternal age (≥40years).
  
  
  
  Using a prospective study design, data were collected by the Department of Obstetrics at the San Joan de Deu Hospital of Barcelona during the 1 June 2009 to 31 May 2012 period. The results were compared across three maternal age groups (≥40 [n=654], 35-39 [n=2781], and <35 [n=7893] years).
  
  
  
  Of the 11328 births recorded during the study period, pregnancy-related complications were more common in women ≥40years of age. The most common disorder was diabetes (8.5% in the ≥40, 5.3% in the 35-39, and 3.0% in the <35years age groups). The women ≥40years of age also had significantly more premature births (p=0.001) and cesarean sections (17% in the ≥40, 12.5% in the 35-39, and 7.9% in the <35-year age groups; p=0.001). Intrauterine growth retardation was significantly more frequent in women aged ≥40years (17.4% in the ≥40, 15% in the 35-39, and 14.0% in the <35-year age groups; p=0.03). Fetal macrosomia was significantly more common in women ≥40years (15.4% in the ≥40, 12.6% in the 35-39, and 12% in the <35-year age groups; p=0.03).
  
  
  
  Maternal age ≥40years was associated with poorer obstetric and perinatal outcomes and increased the risks of cesarean section, intrauterine growth retardation, and fetal macrosomia.
authors.affiliation: BCNatal - Barcelona Center for Maternal Fetal and Neonatal Medicine, Hospital Sant Joan de Deu, University of Barcelona, Pg. Sant Joan de Deu, nº 2 Esplugues, 08950, Barcelona, Spain. Electronic address: yzapata@hsjdbcn.org.
authors.forename: Yesenia
authors.initials: Y
authors.lastname: Zapata-Masias
authors.affiliation: BCNatal - Barcelona Center for Maternal Fetal and Neonatal Medicine, Hospital Sant Joan de Deu, University of Barcelona, Pg. Sant Joan de Deu, nº 2 Esplugues, 08950, Barcelona, Spain. Electronic address: bmarqueta@hsjdbcn.org.
authors.forename: Belén
authors.initials: B
authors.lastname: Marqueta
authors.affiliation: BCNatal - Barcelona Center for Maternal Fetal and Neonatal Medicine, Hospital Sant Joan de Deu, University of Barcelona, Pg. Sant Joan de Deu, nº 2 Esplugues, 08950, Barcelona, Spain. Electronic address: lgomezroig@hsjdbcn.org.
authors.forename: M D
authors.initials: MD
authors.lastname: Gómez Roig
authors.affiliation: BCNatal - Barcelona Center for Maternal Fetal and Neonatal Medicine, Hospital Sant Joan de Deu, University of Barcelona, Pg. Sant Joan de Deu, nº 2 Esplugues, 08950, Barcelona, Spain. Electronic address: edugonzalez@hsjdbcn.org.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Gonzalez-Bosquet
mesh_terms: D000328:Adult; D001724:Birth Weight; D002585:Cesarean Section / Q000706:statistics & numerical data*; D005260:Female; D005317:Fetal Growth Retardation / Q000453:epidemiology*; D005320:Fetal Macrosomia / Q000453:epidemiology*; D006801:Humans; D008423:Maternal Age; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D011256:Pregnancy Outcome / Q000453:epidemiology*; D011254:Pregnancy in Diabetics / Q000453:epidemiology; D047928:Premature Birth / Q000453:epidemiology; D011446:Prospective Studies
keywords: Advanced maternal age; Age over 40years; Cesarean section; IUGR and macrosomia; Late motherhood; Maternal and perinatal morbidity