title: Hepatic expression of miR-122 and antioxidant genes in patients with chronic hepatitis B.
abstract: The pathogenesis of chronic hepatitis B depends on both, the immune response and oxidative stress.
  
  
  
  To assess the hepatic expression of miR-122 and the antioxidant genes: HMOX-1, NQO1 and GFER1, in liver biopsy specimens obtained from patients with chronic hepatitis B, with regard to selected clinical and histological parameters, using RT-PCR.
  
  
  
  The study group comprised 34 HBV-infected patients. Statistically significant associations were found between lower hepatic expression of HMOX-1 and greater severity of liver inflammation (p=0.04). However, significantly higher expression of NQO1 was observed in patients with advanced liver fibrosis (p=0.035). Hepatic expression of miR-122 in HBV patients was not associated with viral load or liver injury.
  
  
  
  The hepatic expression of HMOX-1and NQO1 may be associated with liver injuries in chronic hepatitis B. However, hepatic expression of miR-122 does not seem to correspond to progression of the liver disease.
authors.affiliation: Department of Infectious Diseases and Hepatology, Medical University of Lodz, Łódź, Poland.
authors.forename: Kamila
authors.initials: K
authors.lastname: Wójcik
authors.affiliation: Department of Infectious Diseases and Hepatology, Medical University of Lodz, Łódź, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Piekarska
authors.affiliation: Central Laboratory, Medical University of Lodz, Łódź, Poland.
authors.forename: Bożena
authors.initials: B
authors.lastname: Szymańska
authors.affiliation: Department of Infectious Diseases and Hepatology, Medical University of Lodz, Łódź, Poland.
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Jabłonowska
mesh_terms: D000328:Adult; D003579:Cytochrome Reductases / Q000378:metabolism; D005260:Female; D015870:Gene Expression; D051547:Heme Oxygenase-1 / Q000378:metabolism; D019694:Hepatitis B, Chronic / Q000235:genetics / Q000378:metabolism* / Q000821:virology; D006801:Humans; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008297:Male; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000378:metabolism; D050862:Oxidoreductases Acting on Sulfur Group Donors; D019562:Viral Load; D055815:Young Adult
chemical_list: C531907:MIRN122 microRNA, human; D035683:MicroRNAs; C496541:HMOX1 protein, human; D051547:Heme Oxygenase-1; D003579:Cytochrome Reductases; D016660:NAD(P)H Dehydrogenase (Quinone); C447479:NQO1 protein, human; C500897:GFER protein, human; D050862:Oxidoreductases Acting on Sulfur Group Donors