title: Childhood Obesity: Current Situation and Future Opportunities.
abstract: The early origins of overweight and obesity and the opportunities for early prevention are explored.
  
  
  
  Overweight and obesity prevalence globally has increased at an alarming rate. No single intervention can halt the rise of the obesity epidemic. Particular attention is given to exploring causative factors and preventive measures in early life, when biological determinants of risk trajectories, feeding behaviour and dietary preferences are shaped. Some lifestyle and nutrition modifications in pregnancy and infancy can reduce subsequent obesity risk. Also postnatal infant gut colonisation may modify later obesity risk, but currently available evidence does not allow firm conclusions. Surprisingly, about 3.2 times more systematic reviews (SR) than randomized clinical trials (RCTs) were published on "probiotics" and health, and even 7.9 times more SR than RCTs on "probiotics" and obesity, which is not helpful.
  
  
  
  Multiple research opportunities exist for exploring the early origins of obesity to contribute towards halting the rise in obesity prevalence. Exploring the early development of the microbiome in its complexity, its dependence on dietary and other exogenous factors, and its metabolic and regulatory functions is promising. Meaningful progress for obesity prevention can most likely be achieved by combining several strategies.
authors.affiliation: Ludwig-Maximilians-Universität München, Dr. von Hauner Children's Hospital, University of Munich Medical Center, Munich, Germany.
authors.forename: Berthold
authors.initials: B
authors.lastname: Koletzko
mesh_terms: D002648:Child; D005544:Forecasting; D017408:Guidelines as Topic; D006801:Humans; D050177:Overweight / Q000517:prevention & control; D063766:Pediatric Obesity / Q000517:prevention & control*