title: Changes in Immunohistochemical Protein Levels in Anaplastic Lymphoma Kinase-positive Lung Adenocarcinoma Possibly due to Chemo-radiotherapy.
abstract: To detect the anaplastic lymphoma kinase (ALK) fusion gene in non-small cell lung cancer, immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) are the standard methods. However, there are discrepancies between them. We herein report a 40-year-old woman with ALK fusion-positive adenocarcinoma that changed from positive to negative in IHC due to chemo-radiotherapy. Recurrence of the disease restored the IHC expression, whereas FISH was positive throughout the entire clinical course. Our experience suggests that we should therefore carefully evaluate samples after chemotherapy and radiotherapy.
authors.affiliation: Department of Respiratory Medicine, Sasebo City General Hospital, Japan.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Taniguchi
authors.forename: Takaya
authors.initials: T
authors.lastname: Ikeda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Soda
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Fukuda
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kitazaki
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kohno
mesh_terms: D000230:Adenocarcinoma / Q000276:immunology* / Q000628:therapy*; D000077192:Adenocarcinoma of Lung; D000328:Adult; D000077548:Anaplastic Lymphoma Kinase; D059248:Chemoradiotherapy; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008175:Lung Neoplasms / Q000276:immunology* / Q000628:therapy*; D020794:Receptor Protein-Tyrosine Kinases / Q000276:immunology*
chemical_list: C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases