title: Evaluation of drug provocation test-related anxiety in patients with drug hypersensitivity.
abstract: Drug provocation tests (DPTs) are important in the treatment of patients with drug hypersensitivity (DH), but they carry certain hypersensitivity reaction risks, which lead to procedure-related concerns in patients.
  
  
  
  To investigate DPT-related anxiety and its effect on long-term use of tested drugs.
  
  
  
  The study included patients who underwent DPT from July 1, 2009, to July 1, 2012. After recording the patients' history and characteristics, a variety of psychiatric (Hospital Anxiety and Depression Scale, Panic and Agoraphobia Scale, and the Maudsley Obsessive-Compulsive Inventory) and quality-of-life (36-item Short Form Health Survey) tests were performed. DPT-related anxiety was also evaluated using a visual analog scale. The patients were requestioned about whether they had used the tested drug within 1 year.
  
  
  
  A total of 126 patients were included in the study. According to the Hospital Anxiety and Depression Scale, 23.4% and 30.6% of the patients had depression and anxiety symptoms, respectively. The mean (SD) visual analog scale anxiety scores after a negative DPT result were lower than those before DPTs (2 [2.5] after vs 5.2 [3.4] before; P < .001). In the long term, 15.9% of the patients did not use the drug because of ongoing anxiety related to drug reactions, despite negative DPT results and symptoms indicated for use of the drug.
  
  
  
  Our findings suggest that DPTs in themselves cause significant anxiety in patients with DH. Importantly, anxiety levels decreased after a negative test result. However, our results also suggested that a negative DPT result is not convincing enough for some patients to use the tested drug when needed in the future. Therefore, supporting strategies appear to be the most effective way to eliminate DH-related anxiety of patients.
authors.affiliation: Division of Immunology and Allergy, Department of Chest Diseases, Ankara University School of Medicine, Ankara, Turkey. Electronic address: sadansoyyigit@gmail.com.
authors.forename: Şadan
authors.initials: Ş
authors.lastname: Soyyiğit
authors.affiliation: Division of Immunology and Allergy, Department of Chest Diseases, Ankara University School of Medicine, Ankara, Turkey.
authors.forename: Ömür
authors.initials: Ö
authors.lastname: Aydın
authors.affiliation: Division of Immunology and Allergy, Department of Chest Diseases, Ankara University School of Medicine, Ankara, Turkey.
authors.forename: İnsu
authors.initials: İ
authors.lastname: Yılmaz
authors.affiliation: Division of Immunology and Allergy, Department of Chest Diseases, Ankara University School of Medicine, Ankara, Turkey.
authors.forename: Seçil Kepil
authors.initials: SK
authors.lastname: Özdemir
authors.affiliation: Department of Psychiatry, Ankara University School of Medicine, Ankara, Turkey.
authors.forename: Vesile Şentürk
authors.initials: VŞ
authors.lastname: Cankorur
authors.affiliation: Department of Psychiatry, Ankara University School of Medicine, Ankara, Turkey.
authors.forename: Cem
authors.initials: C
authors.lastname: Atbaşoğlu
authors.affiliation: Division of Immunology and Allergy, Department of Chest Diseases, Ankara University School of Medicine, Ankara, Turkey.
authors.forename: Gülfem Elif
authors.initials: GE
authors.lastname: Çelik
mesh_terms: D000293:Adolescent; D000328:Adult; D001007:Anxiety / Q000175:diagnosis*; D003863:Depression / Q000175:diagnosis; D004342:Drug Hypersensitivity / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007159:Immunologic Tests / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D016037:Single-Blind Method; D055815:Young Adult