title: Apparent Diffusion Coefficient analysis of encephalitis: A comparative study with topographic evaluation and conventional MRI findings.
abstract: OBJECTIVE
  Our purpose was to reveal the efficiency of diffusion weighted imaging (DWI) in the diagnosis of encephalitis, and to determine the relation between the apparent diffusion coefficient (ADC) values, the onset of the clinical symptoms, and the lesion extent.
  
  
  METHODS
  Conventional magnetic resonance imaging (MRI) was performed in 17 patients with encephalitis diagnosed on the basis of laboratory, clinical and radiologic findings during 2009 and 2015. Based on the duration between the onset of the symptoms and the brain MRI findings, the patients were divided into three groups. ADC values of the encephalitis lesion, the lesions' topographic analysis score, deep gray matter involvement, patients' clinical situation and the duration of the arrival to the clinic was examined.
  
  
  RESULTS
  Mean ADC values were 0,988±0,335 x10(-3) mm(2)/s in group I (0-2 days), 1,045±0,347 x10(-3) mm(2)/s in Group-II (3-7 days), 1,451±0,225 x10(-3) mm(2)/s in Group-III (8 days and over). The relation between the ADC values and the duration of the arrival, topographic analysis score, the relation between the patients' clinical situation and the deep gray matter involvement were found to be statistically significant. The deep gray matter involvement was demonstrated more clearly by FLAIR images when compared with DWI.
  
  
  CONCLUSIONS
  Conventional MRI sequences may be insufficient in showing the encephalitis lesion. DWI must be added to the imaging modalities immediately in the cases suspected of having encephalitis.
authors.affiliation: Ahmet Katirag, MD. Resident Assistant, Department of Radiology, Afyon Kocatepe University Faculty of Medicine, Afyonkarahisar, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Katirag
authors.affiliation: Mehtap Beker-Acay, MD. Assistant Professor, Department of Radiology, Afyon Kocatepe University Faculty of Medicine, Afyonkarahisar, Turkey.
authors.forename: Mehtap
authors.initials: M
authors.lastname: Beker-Acay
authors.affiliation: Ebru Unlu, MD. Assistant Professor, Department of Radiology, Afyon Kocatepe University Faculty of Medicine, Afyonkarahisar, Turkey.
authors.forename: Ebru
authors.initials: E
authors.lastname: Unlu
authors.affiliation: Hayri Demirbas M.D. Assistant Professor, Department of Neurology, Afyon Kocatepe University Faculty of Medicine, Afyonkarahisar, Turkey.
authors.forename: Hayri
authors.initials: H
authors.lastname: Demirbas
authors.affiliation: Nese Demirturk MD. Associate Professor, Department of Infectious Diseases, Afyon Kocatepe University Faculty of Medicine, Afyonkarahisar, Turkey.
authors.forename: Nese
authors.initials: N
authors.lastname: Demirturk
keywords: Difffusion weighted imaging; Encephalitis; Magnetic resonance imaging