title: Selective 5-HT7 receptor agonists LP 44 and LP 211 elicit an analgesic effect on formalin-induced orofacial pain in mice.
abstract: OBJECTIVE
  To investigate the antinociceptive effects of pharmacological activation of 5-HT7 receptors on orofacial pain in mice.
  
  
  METHODS
  Nociception was evaluated by using an orofacial formalin test in male Balb-C mice. Selective 5-HT7 receptor agonists, LP 44 and LP 211 (1, 5, and 10 mg/kg), were given intraperitoneally 30 min prior to a formalin injection. A bolus of 10 µl of 4% subcutaneous formalin was injected into the upper lip of mice and facial grooming behaviors were monitored. The behavioral responses consisted of two distinct periods, the early phase corresponding to acute pain (Phase I: 0-12 min) and the late phase (Phase II: 12-30 min).
  
  
  RESULTS
  LP 44 and LP 211 (1, 5, and 10 mg/kg) produced an analgesic effect with reductions in face rubbing time in both Phase I and Phase II of the formalin test.
  
  
  CONCLUSIONS
  Our results suggest that 5-HT7 receptor agonists may be promising analgesic drugs in the treatment of orofacial pain.
authors.affiliation: - Gulhane Medical Academy, Department of Restorative Dentistry and Endodontics, Ankara, Turkey.
authors.forename: Kadriye
authors.initials: K
authors.lastname: Demirkaya
authors.affiliation: - Gulhane Medical Academy, Department of Pediatric Dentistry, Ankara, Turkey.
authors.forename: Özlem Martı
authors.initials: ÖM
authors.lastname: Akgün
authors.affiliation: - Gulhane Medical Academy, Department of Dentomaxillofacial Radiology, Ankara, Turkey.
authors.forename: Buğra
authors.initials: B
authors.lastname: Şenel
authors.affiliation: - Gulhane Medical Academy, Department of Restorative Dentistry and Endodontics, Ankara, Turkey.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Öncel Torun
authors.affiliation: - Gulhane Medical Academy, Department of Pharmacology and Pain Research Centre, Ankara, Turkey.
authors.forename: Melik
authors.initials: M
authors.lastname: Seyrek
authors.affiliation: - Università degli studi di Bari Aldo Moro, Dipartimento di Farmacia - Scienze del Farmaco, Bari, Italy.
authors.forename: Enza
authors.initials: E
authors.lastname: Lacivita
authors.affiliation: - Università degli studi di Bari Aldo Moro, Dipartimento di Farmacia - Scienze del Farmaco, Bari, Italy.
authors.forename: Marcello
authors.initials: M
authors.lastname: Leopoldo
authors.affiliation: - Gulhane Medical Academy, Department of Pharmacology and Pain Research Centre, Ankara, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Doğrul
mesh_terms: D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005157:Facial Pain / Q000139:chemically induced / Q000188:drug therapy*; D005557:Formaldehyde; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010879:Piperazines / Q000627:therapeutic use*; D011985:Receptors, Serotonin; D015203:Reproducibility of Results; D017366:Serotonin Receptor Agonists / Q000627:therapeutic use*; D013376:Substantia Gelatinosa / Q000187:drug effects; D013997:Time Factors; D016896:Treatment Outcome; D014276:Trigeminal Nerve / Q000187:drug effects
chemical_list: D000700:Analgesics; C573815:N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide; D010879:Piperazines; D011985:Receptors, Serotonin; D017366:Serotonin Receptor Agonists; C104425:serotonin 7 receptor; D005557:Formaldehyde