title: In vivo optical monitoring of transcutaneous delivery of calcium carbonate microcontainers.
abstract: We have developed a method for delivery of biocompatible CaCO3 microcontainers (4.0 ± 0.8 µm) containing Fe3O4 nanoparticles (14 ± 5 nm) into skin in vivo using fractional laser microablation (FLMA) provided by a pulsed Er:YAG laser system. Six laboratory rats have been used for the microcontainer delivery and weekly monitoring implemented using an optical coherence tomography and a standard histological analysis. The use of FLMA allowed for delivery of the microcontainers to the depth about 300 μm and creation of a depot in dermis. On the seventh day we have observed the dissolving of the microcontainers and the release of nanoparticles into dermis.
authors.affiliation: National Research Saratov State University, 83 Astrakhanskaya Street, Saratov 410012, Russia; National Research Tomsk State University, 36 Lenin Avenue, Tomsk 634050, Russia.
authors.forename: Elina A
authors.initials: EA
authors.lastname: Genina
authors.affiliation: National Research Saratov State University, 83 Astrakhanskaya Street, Saratov 410012, Russia.
authors.forename: Yulia I
authors.initials: YI
authors.lastname: Svenskaya
authors.affiliation: National Research Saratov State University, 83 Astrakhanskaya Street, Saratov 410012, Russia.
authors.forename: Irina Yu
authors.initials: IY
authors.lastname: Yanina
authors.affiliation: National Research Saratov State University, 83 Astrakhanskaya Street, Saratov 410012, Russia.
authors.forename: Leonid E
authors.initials: LE
authors.lastname: Dolotov
authors.affiliation: Saratov State Medical University, 112 Bolshaya Kazachaya Street, Saratov 410012, Russia.
authors.forename: Nikita A
authors.initials: NA
authors.lastname: Navolokin
authors.affiliation: National Research Saratov State University, 83 Astrakhanskaya Street, Saratov 410012, Russia; National Research Tomsk State University, 36 Lenin Avenue, Tomsk 634050, Russia.
authors.forename: Alexey N
authors.initials: AN
authors.lastname: Bashkatov
authors.affiliation: National Research Saratov State University, 83 Astrakhanskaya Street, Saratov 410012, Russia; Saratov State Medical University, 112 Bolshaya Kazachaya Street, Saratov 410012, Russia.
authors.forename: Georgy S
authors.initials: GS
authors.lastname: Terentyuk
authors.affiliation: Saratov State Medical University, 112 Bolshaya Kazachaya Street, Saratov 410012, Russia.
authors.forename: Alla B
authors.initials: AB
authors.lastname: Bucharskaya
authors.affiliation: Saratov State Medical University, 112 Bolshaya Kazachaya Street, Saratov 410012, Russia.
authors.forename: Galina N
authors.initials: GN
authors.lastname: Maslyakova
authors.affiliation: National Research Saratov State University, 83 Astrakhanskaya Street, Saratov 410012, Russia.
authors.forename: Dmitry A
authors.initials: DA
authors.lastname: Gorin
authors.affiliation: National Research Saratov State University, 83 Astrakhanskaya Street, Saratov 410012, Russia; National Research Tomsk State University, 36 Lenin Avenue, Tomsk 634050, Russia; Institute of Precision Mechanics and Control of RAS, 24 Rabochaya Street, Saratov 410028, Russia.
authors.forename: Valery V
authors.initials: VV
authors.lastname: Tuchin
authors.affiliation: National Research Saratov State University, 83 Astrakhanskaya Street, Saratov 410012, Russia; School of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK.
authors.forename: Gleb B
authors.initials: GB
authors.lastname: Sukhorukov
keywords: (110.4500) Optical coherence tomography; (170.0170) Medical optics and biotechnology; (170.0180) Microscopy; (170.1020) Ablation of tissue; (350.4990) Particles