title: Cinnamomum loureirii Extract Inhibits Acetylcholinesterase Activity and Ameliorates Trimethyltin-Induced Cognitive Dysfunction in Mice.
abstract: The pathogenesis of Alzheimer's disease (AD) has been linked to the deficiency of neurotransmitter acetylcholine (ACh) in the brain, and the main treatment strategy for improving AD symptoms is the inhibition of acetylcholinesterase (AChE) activity. In the present study, we aimed to identify potent AChE inhibitors from Cinnamomum loureirii extract via bioassay-guided fractionation. We demonstrated that the most potent AChE inhibitor present in the C. loureirii extract was 2,4-bis(1,1-dimethylethyl)phenol. To confirm the antiamnesic effects of the ethanol extract of C. loureirii, mice were intraperitoneally injected with the neurotoxin trimethyltin (2.5 mg/kg) to induce cognitive dysfunction, and performance in the Y-maze and passive avoidance tests was assessed. Treatment with C. loureirii extract significantly improved performance in both behavioral tests, suggesting that this extract may be neuroprotective and therefore beneficial in preventing or ameliorating the degenerative processes of AD, potentially by restoring cholinergic function.
authors.affiliation: Department of Food and Biotechnology, Korea University.
authors.forename: Cho Rong
authors.initials: CR
authors.lastname: Kim
authors.forename: Soo Jung
authors.initials: SJ
authors.lastname: Choi
authors.forename: Yoon Kyung
authors.initials: YK
authors.lastname: Kwon
authors.forename: Jae Kyeom
authors.initials: JK
authors.lastname: Kim
authors.forename: Youn-Jung
authors.initials: YJ
authors.lastname: Kim
authors.forename: Gwi Gun
authors.initials: GG
authors.lastname: Park
authors.forename: Dong-Hoon
authors.initials: DH
authors.lastname: Shin
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D045744:Cell Line, Tumor; D002800:Cholinesterase Inhibitors / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use*; D027424:Cinnamomum; D060825:Cognitive Dysfunction / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008813:Mice, Inbred ICR; D009498:Neurotoxins; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use*; D051381:Rats; D014298:Trimethyltin Compounds
chemical_list: D002800:Cholinesterase Inhibitors; D009498:Neurotoxins; D010636:Phenols; D010936:Plant Extracts; D014298:Trimethyltin Compounds; C046488:trimethyltin; D000110:Acetylcholinesterase