title: Pathogenesis of Rushton bodies: A novel hypothesis.
abstract: Rushton bodies (RBs) are one of the characteristic features seen in the epithelial lining of odontogenic cysts mainly radicular, dentigerous and odontogenic keratocyst. It has two different histo-morphological appearances; granular and homogeneous. Although widely investigated, the exact pathogenesis and histogenesis of RBs is still an enigma. Many hypotheses were made in the literature but none has explained conceivably the two histo-morphological appearances of RBs and their association with inflammation. In the present paper the various pathogenesis for the formation of RBs proposed till date are discussed along with proposal for a novel hypothesis. The given hypothesis is mainly related to inflammation and its effect on pore size of basement membrane of odontogenic cystic epithelium. It explains RBs association with inflammation as well as existence of two histo-morphological appearances. The proposed hypothesis also justifies the RB's presence inside the lining epithelium of odontogenic cyst despite its hematogenous origin. Future studies are advocated for isolating RBs using laser capture microdissection and subsequent biochemical, histochemical and electron microscopic analysis to substantiate the proposed hypothesis.
authors.affiliation: Department of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Maheshnagar, Pimpri, Pune 18, Maharashtra, India. Electronic address: gargi14@gmail.com.
authors.forename: Gargi S
authors.initials: GS
authors.lastname: Sarode
authors.affiliation: Department of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Maheshnagar, Pimpri, Pune 18, Maharashtra, India. Electronic address: drsachinsarode@gmail.com.
authors.forename: Sachin C
authors.initials: SC
authors.lastname: Sarode
authors.affiliation: Government Dental College and Hospital, Near Chhatrapati Shivaji Terminus Area, Fort, Mumbai, Maharashtra 400001, India. Electronic address: jvtupkari@gmail.com.
authors.forename: Jagdish V
authors.initials: JV
authors.lastname: Tupkari
authors.affiliation: Department of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Maheshnagar, Pimpri, Pune 18, Maharashtra, India.
authors.forename: Revati
authors.initials: R
authors.lastname: Deshmukh
authors.affiliation: Department of Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Saudi Arabia. Electronic address: dr.ravipatil@gmail.com.
authors.forename: Shankargouda
authors.initials: S
authors.lastname: Patil
mesh_terms: D053523:Amelogenin / Q000378:metabolism; D000818:Animals; D003803:Dentigerous Cyst / Q000473:pathology*; D004847:Epithelial Cells / Q000166:cytology; D004848:Epithelium / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000473:pathology; D008962:Models, Theoretical; D009807:Odontogenic Cysts / Q000473:pathology*; D009808:Odontogenic Tumors
chemical_list: D053523:Amelogenin
keywords: Basement membrane; Exudate; Hyaline bodies; Inflammation; Odontogenic cyst; Red blood cells; Rushton bodies; Transudate