title: A Friendly Relationship between Endophytic Fungi and Medicinal Plants: A Systematic Review.
abstract: Endophytic fungi or endophytes exist widely inside the healthy tissues of living plants, and are important components of plant micro-ecosystems. Over the long period of evolution, some co-existing endophytes and their host plants have established a special relationship with one and another, which can significantly influence the formation of metabolic products in plants, then affect quality and quantity of crude drugs derived from medicinal plants. This paper will focus on the increasing knowledge of relationships between endophytic fungi and medicinal plants through reviewing of published research data obtained from the last 30 years. The analytical results indicate that the distribution and population structure of endophytes can be considerably affected by factors, such as the genetic background, age, and environmental conditions of their hosts. On the other hand, the endophytic fungi can also confer profound impacts on their host plants by enhancing their growth, increasing their fitness, strengthening their tolerances to abiotic and biotic stresses, and promoting their accumulation of secondary metabolites. All the changes are very important for the production of bioactive components in their hosts. Hence, it is essential to understand such relationships between endophytic fungi and their host medicinal plants. Such knowledge can be well exploited and applied for the production of better and more drugs from medicinal plants.
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University Shanghai, China.
authors.forename: Min
authors.initials: M
authors.lastname: Jia
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University Shanghai, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University Shanghai, China.
authors.forename: Hai-Liang
authors.initials: HL
authors.lastname: Xin
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University Shanghai, China.
authors.forename: Cheng-Jian
authors.initials: CJ
authors.lastname: Zheng
authors.affiliation: Department of Physiological Biochemistry, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University Liverpool, UK.
authors.forename: Khalid
authors.initials: K
authors.lastname: Rahman
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University Shanghai, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Han
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University Shanghai, China.
authors.forename: Lu-Ping
authors.initials: LP
authors.lastname: Qin
keywords: endophytic fungi; medicinal plant; plant-microbe interaction; population structure; secondary metabolite