title: Infrared spectroscopic imaging detects chemical modifications in liver fibrosis due to diabetes and disease.
abstract: The importance of stroma as a rich diagnostic region in tissue biopsies is growing as there is an increasing understanding that disease processes in multiple organs can affect the composition of adjacent connective tissue regions. This may be especially true in the liver, since this organ's central metabolic role exposes it to multiple disease processes. We use quantum cascade laser infrared spectroscopic imaging to study changes in the chemical status of hepatocytes and fibrotic regions of liver tissue that result from the progression of liver cirrhosis to hepatocellular carcinoma and the potentially confounding effects of diabetes mellitus.
authors.affiliation: Department of Pathology, University of Illinois at Chicago, 840 S Wood St. 130 CSN, Chicago, IL 60612, USA.
authors.forename: Hari
authors.initials: H
authors.lastname: Sreedhar
authors.affiliation: Department of Pathology, University of Illinois at Chicago, 840 S Wood St. 130 CSN, Chicago, IL 60612, USA; Department of Bioengineering, University of Illinois at Chicago, 851 S. Morgan St. 218 SEO, Chicago, IL 60607, USA.
authors.forename: Vishal K
authors.initials: VK
authors.lastname: Varma
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, 600 S. Matthews Ave. 114 Roger Adams Laboratory, Urbana, IL 61801, USA.
authors.forename: Francesca V
authors.initials: FV
authors.lastname: Gambacorta
authors.affiliation: Department of Pathology, University of Illinois at Chicago, 840 S Wood St. 130 CSN, Chicago, IL 60612, USA.
authors.forename: Grace
authors.initials: G
authors.lastname: Guzman
authors.affiliation: Department of Pathology, University of Illinois at Chicago, 840 S Wood St. 130 CSN, Chicago, IL 60612, USA; Department of Bioengineering, University of Illinois at Chicago, 851 S. Morgan St. 218 SEO, Chicago, IL 60607, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Walsh
keywords: (170.3880) Medical and biological imaging; (170.6510) Spectroscopy, tissue diagnostics; (300.6340) Spectroscopy, infrared