title: PI3 Kinase Pathway Mutations in Human Cancers.
authors.affiliation: Department of Biomedical Engineering, Center for Spatial Systems Biomedicine, Knight Cancer Institute, Oregon Health and Science University, Portland.
authors.forename: Joe W
authors.initials: JW
authors.lastname: Gray
mesh_terms: D000631:Aminopyridines / Q000627:therapeutic use; D058534:Class I Phosphatidylinositol 3-Kinases; D006801:Humans; D007546:Isoquinolines / Q000627:therapeutic use; D058990:Molecular Targeted Therapy; D009025:Morpholines / Q000627:therapeutic use; D009154:Mutation; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D051059:PTEN Phosphohydrolase / Q000037:antagonists & inhibitors / Q000235:genetics*; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics*; D000081082:Phosphoinositide-3 Kinase Inhibitors; D051057:Proto-Oncogene Proteins c-akt / Q000037:antagonists & inhibitors / Q000235:genetics*; D011687:Purines / Q000627:therapeutic use; D052999:Quinazolinones / Q000627:therapeutic use; D015398:Signal Transduction; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
chemical_list: D000631:Aminopyridines; D058534:Class I Phosphatidylinositol 3-Kinases; D007546:Isoquinolines; D009025:Morpholines; D051059:PTEN Phosphohydrolase; D019869:Phosphatidylinositol 3-Kinases; D000081082:Phosphoinositide-3 Kinase Inhibitors; D051057:Proto-Oncogene Proteins c-akt; D011687:Purines; D052999:Quinazolinones; D016159:Tumor Suppressor Protein p53; C571178:NVP-BKM120; C495901:TP53 protein, human; C586691:duvelisib; C484760:PIK3CA protein, human; C494918:AKT1 protein, human; C494929:PTEN protein, human; C552946:idelalisib