title: Aliskiren and l-arginine treatments restore depressed baroreflex sensitivity and decrease oxidative stress in renovascular hypertension rats.
abstract: Renovascular hypertension is characterized by increased angiotensin II and oxidative stress, and by endothelial dysfunction. The purpose of this study was to test whether the administration of aliskiren (ALSK) and l-arginine (l-ARG) would restore impaired baroreflex sensitivity and reduce oxidative stress in a rat renovascular hypertension model. Hypertension was induced by clipping the left renal artery, and the following five groups were created: SHAM; two-kidney, 1-clip (2K1C); 2K1C plus ALSK (ALSK); 2K1C plus l-ARG (l-ARG); and 2K1C plus ALSK+l-ARG (ALSK+l-ARG). After 21 days of treatment, only the ALSK+l-ARG group was effective in normalizing the arterial pressure (108.8±2.8 mm Hg). The l-ARG and ALSK+l-ARG groups did not show hypertrophy of the left ventricle. All the treatments restored the depressed baroreflex sensitivity to values found in the SHAM group. Acute administration of TEMPOL restored the depressed baroreflex sensitivity in the 2K1C group to values that resembled those presented by the other groups. All treatments were effective for an increase in the antioxidant pathway and reduction in the oxidative pathway. In conclusion, the treatment with ALSK or l-ARG reduced oxidative stress and restored reduced baroreflex sensitivity in renovascular hypertension. In addition, the treatments were able to normalize blood pressure and reverse left ventricular hypertrophy when used in combination.
authors.affiliation: Department of Physiological Sciences, Health Sciences Center, Federal University of Espírito Santo, Vitória, Brazil.
authors.forename: Vinicius
authors.initials: V
authors.lastname: Mengal
authors.affiliation: Department of Physiological Sciences, Health Sciences Center, Federal University of Espírito Santo, Vitória, Brazil.
authors.forename: Paulo Hm
authors.initials: PH
authors.lastname: Silva
authors.affiliation: Department of Physiological Sciences, Health Sciences Center, Federal University of Espírito Santo, Vitória, Brazil.
authors.forename: Renata V
authors.initials: RV
authors.lastname: Tiradentes
authors.affiliation: Department of Physiological Sciences, Health Sciences Center, Federal University of Espírito Santo, Vitória, Brazil.
authors.forename: Cintia H
authors.initials: CH
authors.lastname: Santuzzi
authors.affiliation: Department of Physiological Sciences, Health Sciences Center, Federal University of Espírito Santo, Vitória, Brazil.
authors.forename: Simone A
authors.initials: SA
authors.lastname: de Almeida
authors.affiliation: Department of Physiological Sciences, Health Sciences Center, Federal University of Espírito Santo, Vitória, Brazil.
authors.forename: Gabriela C
authors.initials: GC
authors.lastname: Sena
authors.affiliation: Department of Physiological Sciences, Health Sciences Center, Federal University of Espírito Santo, Vitória, Brazil.
authors.forename: Nazare S
authors.initials: NS
authors.lastname: Bissoli
authors.affiliation: Department of Physiological Sciences, Health Sciences Center, Federal University of Espírito Santo, Vitória, Brazil.
authors.forename: Glaucia R
authors.initials: GR
authors.lastname: Abreu
authors.affiliation: Department of Physiological Sciences, Health Sciences Center, Federal University of Espírito Santo, Vitória, Brazil.|Nucleus of Biotechnology, Health Sciences Center, Federal University of Espírito Santo, Vitória, Brazil.
authors.forename: Sonia A
authors.initials: SA
authors.lastname: Gouvea
mesh_terms: D000577:Amides / Q000494:pharmacology*; D000818:Animals; D001120:Arginine / Q000494:pharmacology*; D017704:Baroreflex / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D002374:Catalase / Q000378:metabolism; D005650:Fumarates / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006978:Hypertension, Renovascular / Q000378:metabolism / Q000503:physiopathology*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology
chemical_list: D000577:Amides; D005650:Fumarates; C446481:aliskiren; D001120:Arginine; D002374:Catalase; D013482:Superoxide Dismutase