title: Burning Fat Fuels Leukemic Stem Cell Heterogeneity.
abstract: Obese leukemia patients exhibit reduced survival after chemotherapy, suggesting an important role of adipose tissue in disease progression. In this issue of Cell Stem Cell, Ye et al. (2016) reveal metabolic heterogeneity in leukemic stem cell (LSC) subpopulations and show that chemotherapy-resistant CD36+ LSCs co-opt gonadal adipose tissue to support their metabolism and survival.
authors.affiliation: Department of Medicine, Division of Hematology, Cancer Institute, and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Thomas
authors.affiliation: Department of Medicine, Division of Hematology, Cancer Institute, and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: rmajeti@stanford.edu.
authors.forename: Ravindra
authors.initials: R
authors.lastname: Majeti
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D006801:Humans; D015470:Leukemia, Myeloid, Acute; D014411:Neoplastic Stem Cells; D009765:Obesity