title: Demographic and clinical characteristics related to cognitive decline in Alzheimer disease in China: A multicenter survey from 2011 to 2014.
abstract: Alzheimer disease (AD) is the most frequent cause of dementia. AD diagnosis, progression, and treatment have not been analyzed nationwide in China. The primary aim of this study was to analyze demographic and clinical characteristics related to cognitive decline in AD patients treated at outpatient clinics in China.We performed a retrospective study of 1993 AD patients at 10 cognitive centers across 8 cities in China from March 2011 to October 2014. Of these, 891 patients were followed for more than 1 year.The mean age at diagnosis was 72.0 ± 10.0 years (range 38-96 years), and the mean age at onset of AD was 69.8 ± 9.5 years. Most patients (65.1%) had moderate to severe symptoms at the time of diagnosis, and mean Mini-Mental State Examination at diagnosis was 15.7 ± 7.7. AD patients showed significant cognitive decline at 12 months after diagnosis. Having more than 9 years of formal education was an independent risk factor related to rapid cognitive decline [odds ratio (OR) = 1.80; 95% confidence interval (95% CI): 1.11-2.91]. Early-onset AD patients experienced more rapid cognitive decline than late-onset patients (OR = 1.83; 95% CI: 1.09-3.06).Most AD patients in China had moderate to severe symptoms at the time of diagnosis and experienced significant cognitive decline within 1 year. Rapid cognitive decline in AD was related to having a higher educational level and younger age of onset.
authors.affiliation: aDepartment of Neurology, China-Japanese Friendship Hospital, Beijing bTianjin Key Laboratory of Cerebrovascular and of neurodegenerative diseases, Tianjin Dementia Institute cDepartment of Neurology, Tianjin Huanhu Hospital, Tianjin dDepartment of Neurology, Northern Jiangsu Province Hospital, Affiliated to Yangzhou University, Yangzhou, Jiangsu Province eDepartment of Neurology, Xiangya Hospital, Central South University, Changsha fDepartment of Geriatrics, Shanghai Mental Health Center of Shanghai Jiaotong University School of Medicine, Shanghai gDepartment of neurology, General Hospital of Tianjin Medical University, Tianjin hDepartment of Neurology, Qilu Hospital, Shandong university, Shandong iDepartment of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing jDepartment of Nutrition and Food Science, School of Public Health, Tianjin Medical University kFirst Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin lDepartment of Neurology, Beijing Hospital, Ministry of Health, Beijing mThe Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, Jiangsu Province nDepartment of Neurosurgery, Tianjin Huanhu Hospital, Tianjin, China.
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mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications*; D002681:China; D060825:Cognitive Dysfunction / Q000175:diagnosis* / Q000453:epidemiology* / Q000209:etiology; D003710:Demography; D005260:Female; D006306:Health Surveys; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013997:Time Factors