title: Spectral-domain optical coherence tomography findings of the macula in 500 consecutive patients with uveitis.
abstract: PurposeTo analyze the macular structure in a large series of consecutive patients with different types of uveitis using spectral-domain optical coherence tomography (SD-OCT).Patients and methodsFive hundred eyes of 500 consecutive patients with anterior, intermediate, posterior, and panuveitis underwent standardized macular examination using SD-OCT. Central retinal thickness (CRT), macular volume (MV), and presence of cystoid macular edema (CME), diffuse macular edema (DME), serous retinal detachment (SRD), epiretinal membrane with (ERM+) and without (ERM-) retinal surface wrinkling were determined.ResultsThe anatomic location of inflammation affected significantly CRT and MV (P<0.001, respectively), with the highest values in intermediate and panuveitis. CME was seen in 25% of all uveitic eyes, DME in 11%, SRD in 8%, ERM+ in 18%, and ERM- in 13%. CME was most frequent in intermediate (40%) and panuveitis (36%); DME was most frequent in panuveitis (18%) and posterior uveitis (17%); SRD was most frequent in panuveitis (15%) and posterior uveitis (10%); ERM+ was most frequent in panuveitis (45%) and intermediate uveitis (30%); and ERM- was most frequent in intermediate (14%) and posterior uveitis (15%).ConclusionSD-OCT of the macula is recommended for all uveitis patients. CRT, MV, and the incidence of CME were highest in intermediate and panuveitis.
authors.affiliation: Department of Ophthalmology, University of Cologne, Cologne, Germany.
authors.forename: R S
authors.initials: RS
authors.lastname: Grajewski
authors.affiliation: Department of Ophthalmology, University of Cologne, Cologne, Germany.
authors.forename: A C
authors.initials: AC
authors.lastname: Boelke
authors.affiliation: Department of Biometry and Epidemiology, University Erlangen-Nuremberg, Erlangen, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Adler
authors.affiliation: Department of Ophthalmology, University of Cologne, Cologne, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Meyer
authors.affiliation: Department of Ophthalmology, University of Cologne, Cologne, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Caramoy
authors.affiliation: Department of Ophthalmology, University of Cologne, Cologne, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Kirchhof
authors.affiliation: Department of Ophthalmology, University of Cologne, Cologne, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Cursiefen
authors.affiliation: Department of Ophthalmology, University of Cologne, Cologne, Germany.
authors.forename: L M
authors.initials: LM
authors.lastname: Heindl
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D019773:Epiretinal Membrane / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007223:Infant; D008266:Macula Lutea / Q000000981:diagnostic imaging* / Q000473:pathology; D008269:Macular Edema / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D012163:Retinal Detachment / Q000000981:diagnostic imaging*; D041623:Tomography, Optical Coherence; D014605:Uveitis / Q000145:classification / Q000000981:diagnostic imaging*