title: Bensal HP Attenuates the Inflammatory Response in Hair Shaving Associated Dermatitis.
abstract: Shaving is an ubiquitous practice, and cutaneous irritation and inflammation are common sequelae, which may be worsened by underlying skin conditions or poor hair removal techniques. Moisturizing shaving creams and aftershaves are available to help maintain or restore the epidermal barrier; however, many continue to suffer from post-shave redness, itching, and pain. To reduce post-shave inflammation, some products have included botanical and other natural ingredients, which are often favored by consumers. We evaluated Bensal HP, an ointment containing 3% oak bark extract, 3% salicylic acid, and 6% benzoic acid, which has documented anti-inflammatory and antimicrobial properties, in a murine model of shave irritation to determine whether it would be useful in this clinical setting. Shaving dermatitis was simulated using a depilatory agent and electric clippers, and the shaved area was photographed and treated with Bensal HP daily for four days. Compared to untreated controls, mice treated with Bensal HP experienced a visible reduction in skin irritation and inflammation. These findings were mirrored on histology, as Bensal HP-treated areas demonstrated increased epidermal integrity and decreased dermal inflammatory infiltrate compared to untreated skin. Using immunohistochemistry, fewer neutrophils and macrophages were noted, and cytokine analysis also revealed decreased IL-6 in Bensal HP-treated skin at 24 and 96 hours after shaving. These results highlight the potential of Bensal HP as an anti-inflammatory treatment for shave irritation. Given the product's application against a variety of inflammatory and infectious skin disorders, its use against shave irritation may also improve comorbid skin conditions, such as pseudofolliculitis barbae. <br /><br /> <em>J Drugs Dermatol.</em> 2016;15(7):836-840.
authors.forename: Anjana
authors.initials: A
authors.lastname: Ray
authors.forename: Breanne
authors.initials: B
authors.lastname: Mordorski
authors.forename: Angelo
authors.initials: A
authors.lastname: Landriscina
authors.forename: Jamie
authors.initials: J
authors.lastname: Rosen
authors.forename: Joshua
authors.initials: J
authors.lastname: Nosanchuk
authors.forename: Adam
authors.initials: A
authors.lastname: Friedman
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D019817:Benzoic Acid / Q000008:administration & dosage*; D003872:Dermatitis / Q000188:drug therapy* / Q000209:etiology* / Q000473:pathology; D006204:Hair Removal / Q000009:adverse effects* / Q000379:methods; D007249:Inflammation / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D009824:Ointments; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage*; D020156:Salicylic Acid / Q000008:administration & dosage*
chemical_list: D009824:Ointments; D010936:Plant Extracts; D019817:Benzoic Acid; D020156:Salicylic Acid