title: [Association between serum levels of S100A8/S100A9 and clinical features of colorectal cancer patients].
abstract: OBJECTIVE
  To analyze the association between serum levels of S100A8/S100A9 and clinicopathological features of colorectal cancer patients.
  
  
  METHODS
  A total of 82 patients with CRC and 14 healthy controls were enrolled for this study. The levels of S100A8 and S100A9 in serum were detected by ELISA assay. The association between S100A8/S100A9 and clinicopathological features was analyzed by student-t test and one-way ANOVA. Receiver Operating Characteristic curve was used to analyze diagnostic efficiency of serum S100A8 and S100A9 for colon rectal cancer. Logistic regression model was also established to analyze the possible risk factors for elevation of S100A8/S100A9.
  
  
  RESULTS
  The levels of S100A8 and S100A9 were (1 403.3±593.7) and (2 890.3±994.9) pg/mL in patients with colon cancer, and (712.8±265.3) and (1 492.7±564.6) pg/mL in controls, respectively, with significant difference between the two groups (P<0.01). The similar results were found in rectal cancer patients, with a level of S100A8 and S100A9 at (1 417.7±666.5) and (3 026.7±887.6) pg/mL, respectively. Diagnostic sensitivity and specificity of S100A8 and S100A9 are better than traditional biomarkers. The levels of S100A9 in serum of CRC patients were correlated with clinical stages and distant metastasis. Serum levels of S100A9 in patients of stage III [(3 111.9±178.5) pg/mL] and stage IV [(3 831.4±278.5) pg/mL] were significantly (P<0.01) higher than that in stage I [(2 276.1±167.4) pg/mL], whereas there was significant change in S100A8 levels. Logistic regression showed the possible risk factors for the elevation of S100A9, including depth of invasion, lymphatic metastasis and degree of differentiation (P<0.05).
  
  
  CONCLUSIONS
  Serum level of S100A8 and S100A9 in CRC patients were significantly increased and serum level of S100A9 was positively correlated with the malignant features of CRC.
authors.affiliation: Department of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha 410013; Hunan Key Laboratory of Non-resolving Inflammation and Cancer, Third Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Shu
authors.affiliation: Department of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha 410013; Hunan Key Laboratory of Non-resolving Inflammation and Cancer, Third Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Lian
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha 410013; Hunan Key Laboratory of Non-resolving Inflammation and Cancer, Third Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wagn
authors.affiliation: Department of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha 410013; Hunan Key Laboratory of Non-resolving Inflammation and Cancer, Third Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Shen
authors.affiliation: Hunan Key Laboratory of Non-resolving Inflammation and Cancer, Third Xiangya Hospital, Central South University, Changsha 410013; Cancer Research Institute, Central South University, Changsha 410078, China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha 410013; Hunan Key Laboratory of Non-resolving Inflammation and Cancer, Third Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Shourong
authors.initials: S
authors.lastname: Shen
authors.affiliation: Hunan Key Laboratory of Non-resolving Inflammation and Cancer, Third Xiangya Hospital, Central South University, Changsha 410013; Cancer Research Institute, Central South University, Changsha 410078, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Ma
authors.affiliation: Department of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha 410013; Hunan Key Laboratory of Non-resolving Inflammation and Cancer, Third Xiangya Hospital, Central South University, Changsha 410013.
authors.forename: Xiayu
authors.initials: X
authors.lastname: Li
mesh_terms: D040501:Calgranulin A; D040502:Calgranulin B; D015179:Colorectal Neoplasms; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D008207:Lymphatic Metastasis; D012307:Risk Factors
chemical_list: D040501:Calgranulin A; D040502:Calgranulin B