title: Noncoding RNAs Regulating NF-κB Signaling.
abstract: As transcription factors that regulate expression of a variety of genes essential for diverse physiological and pathological processes, nuclear factor kappa B (NF-κB) family molecules play important roles in the development and progression of malignant tumor, and constitutive activation of NF-κB has been evidenced in various types of tumor tissues. Underlying its pathologic role, deregulated expression and/or transactivating activity of NF-κB usually involves multiple layers of molecular mechanisms. Noncoding RNAs, including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), are known to modulate expression and biological functions of regulatory proteins in a variety of cancer contexts. In this chapter, the regulatory role of miRNAs and lncRNAs in NF-κB signaling in malignant diseases will be discussed.
authors.affiliation: Zhongshan School of Medicine, Sun Yat-sen University, 74 Zhongshan Road II, Guangzhou, China. limf@mail.sysu.edu.cn.
authors.forename: Mengfeng
authors.initials: M
authors.lastname: Li
authors.affiliation: Zhongshan School of Medicine, Sun Yat-sen University, 74 Zhongshan Road II, Guangzhou, China.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Guan
mesh_terms: D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D016328:NF-kappa B / Q000235:genetics* / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics*; D062085:RNA, Long Noncoding / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics
chemical_list: D035683:MicroRNAs; D016328:NF-kappa B; D062085:RNA, Long Noncoding
keywords: NF-κB; Noncoding RNA; Therapeutics; Tumorigenesis; lncRNAs; miRNAs