title: Increased MicroRNA-1266 levels as a biomarker for disease activity in psoriasis vulgaris.
abstract: BACKGROUND
  Increasing evidence has shown that serum microRNA (miR) levels are useful biomarkers for the diagnosis, prognosis, and therapeutic value in various diseases. Psoriasis is characterized by a specific miR expression profile, with a characteristic miR signature, distinct from that of healthy skin.
  
  
  OBJECTIVE
  To understand the role of miR-1266 in the pathogenesis of psoriasis and to explore if it has the potential as a blood biomarker. We assessed serum miR-1266 levels in patients with psoriasis before and after treatment and compared it with controls. In addition, we evaluated the relationship between miR-1266 and clinical severity in psoriasis before and after treatment.
  
  
  METHODS
  miR-1266 was measured using real-time polymerase chain reaction in 35 patients with chronic plaque psoriasis and 35 healthy controls before and after treatment. Moreover, the correlation between miR-1266 levels and psoriasis area and severity index score was determined.
  
  
  RESULTS
  Serum miR-1266 levels were considerably higher in patients with psoriasis than in healthy control subjects. Furthermore, miR-1266 levels showed a strong positive correlation with psoriasis area and severity index score before and after treatment, having a marked decline with therapy.
  
  
  CONCLUSIONS
  miR-1266 may have an important role in the pathogenesis of psoriasis vulgaris. This may presumably have possible future implications on the treatment of this chronic disease.
authors.affiliation: Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Ain Shams University, Cairo, Egypt. drnevins@hotmail.com.
authors.forename: Neveen Salah
authors.identifier: http://orcid.org/0000-0002-9705-2186
authors.initials: NS
authors.lastname: Seifeldin
authors.affiliation: Department of Medical Microbiology and Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
authors.forename: Shereen Bendary
authors.initials: SB
authors.lastname: El Sayed
authors.affiliation: Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
authors.forename: Marwa Kamal
authors.initials: MK
authors.lastname: Asaad
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood*; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood* / Q000188:drug therapy; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; C571915:MIRN1266 microRNA, human; D035683:MicroRNAs