title: The Drosophila neurogenin Tap functionally interacts with the Wnt-PCP pathway to regulate neuronal extension and guidance.
abstract: The neurogenin (Ngn) transcription factors control early neurogenesis and neurite outgrowth in mammalian cortex. In contrast to their proneural activity, their function in neurite growth is poorly understood. Drosophila has a single predicted Ngn homolog, Tap, of unknown function. Here we show that Tap is not a proneural protein in Drosophila but is required for proper axonal growth and guidance of neurons of the mushroom body, a neuropile required for associative learning and memory. Genetic and expression analyses suggest that Tap inhibits excessive axonal growth by fine regulation of the levels of the Wnt signaling adaptor protein Dishevelled.
authors.affiliation: VIB Center for the Biology of Disease, VIB, Leuven 3000, Belgium Center for Human Genetics, University of Leuven School of Medicine, Leuven 3000, Belgium Program in Molecular and Developmental Genetics, Doctoral School for Biomedical Sciences, University of Leuven School of Medicine, Leuven 3000, Belgium.
authors.forename: Liqun
authors.initials: L
authors.lastname: Yuan
authors.affiliation: VIB Center for the Biology of Disease, VIB, Leuven 3000, Belgium Center for Human Genetics, University of Leuven School of Medicine, Leuven 3000, Belgium Program in Molecular and Developmental Genetics, Doctoral School for Biomedical Sciences, University of Leuven School of Medicine, Leuven 3000, Belgium Medical College, Henan University of Science and Technology, Luoyang, Henan Province 471003, China.
authors.forename: Shu
authors.initials: S
authors.lastname: Hu
authors.affiliation: VIB Center for the Biology of Disease, VIB, Leuven 3000, Belgium Center for Human Genetics, University of Leuven School of Medicine, Leuven 3000, Belgium Program in Molecular and Developmental Genetics, Doctoral School for Biomedical Sciences, University of Leuven School of Medicine, Leuven 3000, Belgium.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Okray
authors.affiliation: Laboratoire de Génétique du Développement, Université Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires (IBMM), Gosselies 6041, Belgium.
authors.forename: Xi
authors.initials: X
authors.lastname: Ren
authors.affiliation: VIB Center for the Biology of Disease, VIB, Leuven 3000, Belgium Center for Human Genetics, University of Leuven School of Medicine, Leuven 3000, Belgium.
authors.forename: Natalie
authors.initials: N
authors.lastname: De Geest
authors.affiliation: VIB Center for the Biology of Disease, VIB, Leuven 3000, Belgium Center for Human Genetics, University of Leuven School of Medicine, Leuven 3000, Belgium.
authors.forename: Annelies
authors.initials: A
authors.lastname: Claeys
authors.affiliation: VIB Center for the Biology of Disease, VIB, Leuven 3000, Belgium Center for Human Genetics, University of Leuven School of Medicine, Leuven 3000, Belgium.
authors.forename: Jiekun
authors.initials: J
authors.lastname: Yan
authors.affiliation: Laboratoire de Génétique du Développement, Université Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires (IBMM), Gosselies 6041, Belgium.
authors.forename: Eric
authors.initials: E
authors.lastname: Bellefroid
authors.affiliation: VIB Center for the Biology of Disease, VIB, Leuven 3000, Belgium Center for Human Genetics, University of Leuven School of Medicine, Leuven 3000, Belgium Program in Molecular and Developmental Genetics, Doctoral School for Biomedical Sciences, University of Leuven School of Medicine, Leuven 3000, Belgium bassem.hassan@icm-institute.org xiao-jiang.quan@cme.vib-kuleuven.be.
authors.forename: Bassem A
authors.identifier: 0000-0001-9533-4908
authors.initials: BA
authors.lastname: Hassan
authors.affiliation: VIB Center for the Biology of Disease, VIB, Leuven 3000, Belgium Center for Human Genetics, University of Leuven School of Medicine, Leuven 3000, Belgium bassem.hassan@icm-institute.org xiao-jiang.quan@cme.vib-kuleuven.be.
authors.forename: Xiao-Jiang
authors.initials: XJ
authors.lastname: Quan
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism; D000818:Animals; D000071437:Axon Guidance / Q000235:genetics / Q000502:physiology; D001369:Axons / Q000378:metabolism; D016764:Cell Polarity / Q000235:genetics / Q000502:physiology*; D004330:Drosophila; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D024521:Mushroom Bodies / Q000378:metabolism; D009479:Neuropeptides / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D060449:Wnt Signaling Pathway / Q000235:genetics / Q000502:physiology*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D029721:Drosophila Proteins; D009479:Neuropeptides; C107036:Tap protein, Drosophila; D014157:Transcription Factors
keywords: Axonal growth; Mushroom body; Neurogenin; Wnt signaling