title: Occupational Noise Frequencies and the Incidence of Hypertension in a Retrospective Cohort Study.
abstract: Occupational noise exposure is associated with cardiovascular disease, but little is known about the contributions of noise frequency components. This retrospective study investigated the relationship between exposure to different noise frequencies and the incidence of hypertension. A cohort of 1,002 volunteers from 4 machinery and equipment manufacturing companies in Taichung, Taiwan, was followed from 1973 to 2012. Personal noise measurements and environmental octave-band analyses were performed to divide subjects into different exposure groups. Cox regression models were used to estimate the relative risk of hypertension. Participants exposed to ≥80 A-weighted decibels (dBA) over 8 years had a higher relative risk of hypertension (relative risk = 1.38, 95% confidence interval: 1.02, 1.85) compared with those exposed to <75 dBA. Significant exposure-response patterns were observed between incident hypertension and stratum of noise exposure at frequencies of 250 Hz, 1 kHz, 2 kHz, 4 kHz, and 8 kHz. The strongest effect was found at 4 kHz; a 20-dBA increase in noise exposure at 4 kHz was associated with a 34% higher risk of hypertension (relative risk = 1.34, 95% confidence interval: 1.01, 1.77). Occupational noise exposure may be associated with an increased risk of hypertension, and the 4 kHz component of occupational noise exposure may have the strongest relationship with hypertension.
authors.forename: Chiu-Shong
authors.initials: CS
authors.lastname: Liu
authors.forename: Li-Hao
authors.initials: LH
authors.lastname: Young
authors.forename: Tzu-Yi
authors.initials: TY
authors.lastname: Yu
authors.forename: Bo-Ying
authors.initials: BY
authors.lastname: Bao
authors.forename: Ta-Yuan
authors.initials: TY
authors.lastname: Chang
mesh_terms: D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology* / Q000208:ethnology; D015994:Incidence; D008297:Male; D009623:Noise, Occupational / Q000009:adverse effects*; D016273:Occupational Exposure / Q000009:adverse effects; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012306:Risk; D013624:Taiwan / Q000453:epidemiology
keywords: hypertension; incidence; noise frequency analysis; occupational noise; retrospective cohort studies