title: Multivariate Neural Representations of Value during Reward Anticipation and Consummation in the Human Orbitofrontal Cortex.
abstract: The role of the orbitofrontal cortex (OFC) in value processing is a focus of research. Conventional imaging analysis, where smoothing and averaging are employed, may not be sufficiently sensitive in studying the OFC, which has heterogeneous anatomical structures and functions. In this study, we employed representational similarity analysis (RSA) to reveal the multi-voxel fMRI patterns in the OFC associated with value processing during the anticipatory and the consummatory phases. We found that multi-voxel activation patterns in the OFC encoded magnitude and partial valence information (win vs. loss) but not outcome (favourable vs. unfavourable) during reward consummation. Furthermore, the lateral OFC rather than the medial OFC encoded loss information. Also, we found that OFC encoded values in a similar way to the ventral striatum (VS) or the anterior insula (AI) during reward anticipation regardless of motivated response and to the medial prefrontal cortex (MPFC) and the VS in reward consummation. In contrast, univariate analysis did not show changes of activation in the OFC. These findings suggest an important role of the OFC in value processing during reward anticipation and consummation.
authors.affiliation: Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Room 606, South Building, 16 Lincui Road, Beijing, Beijing, 100101 China.|Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics (MOE &STCSM), East China Normal University, Room 213, Junxiu Building, 3663 North Zhongshan Road, Shanghai, 200062 China.
authors.forename: Chao
authors.initials: C
authors.lastname: Yan
authors.affiliation: Department of Psychiatry, Cambridge Biomedical Campus, University of Cambridge, Cambridge, CB2 0SP UK.
authors.forename: Li
authors.initials: L
authors.lastname: Su
authors.affiliation: Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Room 606, South Building, 16 Lincui Road, Beijing, Beijing, 100101 China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Room 606, South Building, 16 Lincui Road, Beijing, Beijing, 100101 China.
authors.forename: Ting
authors.initials: T
authors.lastname: Xu
authors.affiliation: Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai, 200031 China.
authors.forename: Da-Zhi
authors.initials: DZ
authors.lastname: Yin
authors.affiliation: Shanghai Key Laboratory of MRI, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062 China.
authors.forename: Ming-Xia
authors.initials: MX
authors.lastname: Fan
authors.affiliation: Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics (MOE &STCSM), East China Normal University, Room 213, Junxiu Building, 3663 North Zhongshan Road, Shanghai, 200062 China.
authors.forename: Ci-Ping
authors.initials: CP
authors.lastname: Deng
authors.affiliation: Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics (MOE &STCSM), East China Normal University, Room 213, Junxiu Building, 3663 North Zhongshan Road, Shanghai, 200062 China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics (MOE &STCSM), East China Normal University, Room 213, Junxiu Building, 3663 North Zhongshan Road, Shanghai, 200062 China.
authors.forename: Zhao-Xin
authors.initials: ZX
authors.lastname: Wang
authors.affiliation: Department of General Adult Psychiatry, Castle Peak Hospital, 15 Tsing Chung Koon Road, Tuen Mun, N.T. Hong Kong Special Administrative Region, China.
authors.forename: Eric F C
authors.initials: EF
authors.lastname: Cheung
authors.affiliation: Department of Psychiatry, University of Minnesota, F282/2A West 2450 Riverside Avenue, Minneapolis, MN 55454 USA.
authors.forename: Kelvin O
authors.initials: KO
authors.lastname: Lim
authors.affiliation: Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Room 606, South Building, 16 Lincui Road, Beijing, Beijing, 100101 China.
authors.forename: Raymond C K
authors.initials: RC
authors.lastname: Chan
mesh_terms: D000328:Adult; D059031:Anticipation, Psychological / Q000502:physiology*; D001931:Brain Mapping; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*; D009042:Motivation / Q000502:physiology; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging / Q000502:physiology*; D012201:Reward; D055815:Young Adult