title: HLA-A, -B, -C, -DRB1 and -DQB1 alleles and haplotypes in 951 Southeast Asia Malays from Peninsular Malaysia.
abstract: A total of 951 Southeast Asia Malays from Peninsular Malaysia were genotyped for HLA-A, -B, -C -DRB1, and -DQB1 loci using polymerase chain reaction sequence-specific oligonucleotide probe hybridization methods. In this report, there were significant deviation from Hardy-Weinberg proportions for the HLA-A (p<0.0001), -B (p<0.0001), -DRB1 (p<0.0001) and -DQB1 (p<0.01) loci. Minor deviations from HWEP were detected for HLA-C (p=0.01). This genotype data was available in Allele Frequencies Network Database (AFND) Gonzalez-Galarza et al. (2015).
authors.affiliation: Allergy and Immunology Research Center, Institute for Medical Research, Kuala Lumpur, Malaysia. Electronic address: tanlk@imr.gov.my.
authors.forename: Lay-Kim
authors.initials: LK
authors.lastname: Tan
authors.affiliation: Allergy and Immunology Research Center, Institute for Medical Research, Kuala Lumpur, Malaysia.
authors.forename: Baharin
authors.initials: B
authors.lastname: Mohd-Farid
authors.affiliation: Allergy and Immunology Research Center, Institute for Medical Research, Kuala Lumpur, Malaysia.
authors.forename: Sulaiman
authors.initials: S
authors.lastname: Salsabil
authors.affiliation: Department of Medicine, Putrajaya Hospital, Wilayah Persekutuan Putrajaya, Malaysia.
authors.forename: Hussein
authors.initials: H
authors.lastname: Heselynn
authors.affiliation: Department of Medicine, Hospital Raja Perempuan Bainun, Ipoh, Perak, Malaysia; Universiti Kuala Lumpur, Royal College of Medicine Perak, No 3, Jalan Greentown, 30450 Ipoh, Perak, Malaysia.
authors.forename: Sulaiman
authors.initials: S
authors.lastname: Wahinuddin
authors.affiliation: Department of Medicine, Hospital Selayang, Selangor, Malaysia.
authors.forename: Ing-Soo
authors.initials: IS
authors.lastname: Lau
authors.affiliation: Department of Medicine, Hospital Tunku Ja'afar Seremban, Negari Sembilan, Malaysia.
authors.forename: Suk-Chyn
authors.initials: SC
authors.lastname: Gun
authors.affiliation: Department of Medicine, Putrajaya Hospital, Wilayah Persekutuan Putrajaya, Malaysia.
authors.forename: Sharil
authors.initials: S
authors.lastname: Nor-Suhaila
authors.affiliation: Department of Medicine, Putrajaya Hospital, Wilayah Persekutuan Putrajaya, Malaysia.
authors.forename: M
authors.initials: M
authors.lastname: Eashwary
authors.affiliation: Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Center, Selangor, Malaysia.
authors.forename: Mohamed Said
authors.initials: MS
authors.lastname: Mohd-Shahrir
authors.affiliation: Department of Medicine, Tengku Ampuan Afzan Hospital, Kuantan, Pahang, Malaysia.
authors.forename: Mohd-Mokhtar
authors.initials: MM
authors.lastname: Ainon
authors.affiliation: Department of Medicine, Hospital Selayang, Selangor, Malaysia.
authors.forename: Rosman
authors.initials: R
authors.lastname: Azmillah
authors.affiliation: Department of Medicine, Hospital Raja Perempuan Bainun, Ipoh, Perak, Malaysia.
authors.forename: Othman
authors.initials: O
authors.lastname: Muhaini
authors.affiliation: Allergy and Immunology Research Center, Institute for Medical Research, Kuala Lumpur, Malaysia.
authors.forename: Murad
authors.initials: M
authors.lastname: Shahnaz
authors.affiliation: Allergy and Immunology Research Center, Institute for Medical Research, Kuala Lumpur, Malaysia; Rheumatology Unit, Department of Medicine, CMM L8:O4, Karolinska University Hospital and Karolinska Institutet, 17176 Stockholm, Sweden. Electronic address: toocl@imr.gov.my.
authors.forename: Chun-Lai
authors.initials: CL
authors.lastname: Too
mesh_terms: D000483:Alleles; D001210:Asia, Southeastern; D030561:Databases, Nucleic Acid; D005006:Ethnicity; D005787:Gene Frequency; D005828:Genetics, Population; D015234:HLA-A Antigens / Q000235:genetics*; D015796:HLA-B27 Antigen / Q000235:genetics*; D015236:HLA-C Antigens / Q000235:genetics*; D059866:HLA-DQ beta-Chains / Q000235:genetics*; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D008296:Malaysia / Q000453:epidemiology
chemical_list: D015234:HLA-A Antigens; C090660:HLA-B protein, human; D015796:HLA-B27 Antigen; D015236:HLA-C Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D059811:HLA-DRB1 Chains
keywords: Genetic; HLA alleles; Malays; Population