title: Possible Familial Presentation in Two Siblings with Carotid Fibromuscular Dysplasia.
abstract: Fibromuscular dysplasia (FMD) is a nonatherosclerotic, noninflammatory vascular disease which can affect the cervical, renal and visceral arteries. Here we report on two sisters diagnosed with carotid FMD at the same age, presenting with similar symptoms of pulsating tinnitus. The familial presentation of this rare disorder attracted our attention and was suggestive of a genetic etiology. Conservative treatment with aspirin was initiated. Carotid FMD is a rare disorder of which the exact pathophysiology is not known. A review of the literature on the clinical presentation, diagnosis and management is presented. In addition possible etiological factors and the genetic nature of the disease are discussed.
authors.affiliation: a Department of Vascular Surgery , Leuven , Belgium.
authors.forename: H
authors.initials: H
authors.lastname: Topal
authors.affiliation: b Department of Neurology, University Hospitals Leuven , Leuven , Belgium.
authors.forename: R
authors.initials: R
authors.lastname: Lemmens
authors.affiliation: a Department of Vascular Surgery , Leuven , Belgium.
authors.forename: I
authors.initials: I
authors.lastname: Fourneau
mesh_terms: D000328:Adult; D002340:Carotid Artery Diseases / Q000175:diagnosis* / Q000235:genetics*; D000072226:Computed Tomography Angiography / Q000379:methods; D005260:Female; D005352:Fibromuscular Dysplasia / Q000175:diagnosis* / Q000235:genetics*; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods; D008991:Monitoring, Physiologic; D035583:Rare Diseases; D035781:Siblings; D014012:Tinnitus / Q000175:diagnosis / Q000209:etiology