title: Oxidative stress in otosclerosis.
abstract: OBJECTIVE
  Otosclerosis is a disease involving abnormal bone turnover in the human otic capsule that results in hearing loss. Several hypotheses have been suggested for the etiopathogenesis of otosclerosis; however, its etiology remains unclear.
  
  
  METHODS
  This study evaluated the correlation between otosclerosis and levels of paraoxonase-1 (PON1), arylesterase, total antioxidant status, total oxidant status (TOS), oxidative stress index (OSI), total sulfhydryl (-SH) groups, lipid hydroperoxide, and ceruloplasmin in the serum of otosclerosis patients and healthy subjects with respect to oxidative stress.
  
  
  RESULTS
  In our study, TOS and OSI levels were higher in the otosclerosis patients than in the controls. The PON1 levels showed that oxidative stress was severe, and as a result, antioxidants were consumed and depleted.
  
  
  CONCLUSIONS
  When an imbalance between oxygen free radical production and antioxidative defense mechanisms occurs, reactive oxygen species levels may increase, which in turn may damage cells and tissues through the peroxidation of phospholipid membrane structures. The body initially responds with increased antioxidant production, but if the oxidative stress is severe, decreased antioxidant levels may result. This study reports expression levels of oxidative stress species in otosclerosis patients.
authors.affiliation: a Faculty of Medicine, Otolaryngology Department , Inonu University , Malatya , Turkey.
authors.forename: Elif
authors.initials: E
authors.lastname: Baysal
authors.affiliation: b Ersin Aslan State Hospital , Gaziantep , Turkey.
authors.forename: Secaattin
authors.initials: S
authors.lastname: Gulsen
authors.affiliation: c Midyat State Hospital , Mardin , Turkey.
authors.forename: Ismail
authors.initials: I
authors.lastname: Aytac
authors.affiliation: d Faculty of Medicine, Otolaryngology Department , Gaziantep University , Gaziantep , Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Celenk
authors.affiliation: e Antalya Education and Research Hospital , Antalya , Turkey.
authors.forename: Nuray
authors.initials: N
authors.lastname: Ensari
authors.affiliation: f Faculty of Medicine, Biochemistry Department , Gaziantep University , Gaziantep , Turkey.
authors.forename: Seyithan
authors.initials: S
authors.lastname: Taysi
authors.affiliation: g Faculty of Medicine, Otolaryngology Department , Harran University , Sanliurfa , Turkey.
authors.forename: Habib
authors.initials: H
authors.lastname: Binici
authors.affiliation: d Faculty of Medicine, Otolaryngology Department , Gaziantep University , Gaziantep , Turkey.
authors.forename: Cengiz
authors.initials: C
authors.lastname: Durucu
authors.affiliation: d Faculty of Medicine, Otolaryngology Department , Gaziantep University , Gaziantep , Turkey.
authors.forename: Semih
authors.initials: S
authors.lastname: Mumbuc
authors.affiliation: d Faculty of Medicine, Otolaryngology Department , Gaziantep University , Gaziantep , Turkey.
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Kanlikama
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D043303:Aryldialkylphosphatase / Q000097:blood*; D002265:Carboxylic Ester Hydrolases / Q000097:blood; D016022:Case-Control Studies; D002570:Ceruloplasmin / Q000378:metabolism; D005260:Female; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008875:Middle Aged; D010040:Otosclerosis / Q000097:blood / Q000378:metabolism*; D018384:Oxidative Stress
chemical_list: D000975:Antioxidants; D008054:Lipid Peroxides; D002570:Ceruloplasmin; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human
keywords: Otosclerosis; Oxidative stress