title: Interleukin-6 and associated cytokine responses to an acute bout of high-intensity interval exercise: the effect of exercise intensity and volume.
abstract: Acute increases in interleukin (IL)-6 following prolonged exercise are associated with the induction of a transient anti-inflammatory state (e.g., increases in IL-10) that is partly responsible for the health benefits of regular exercise. The purposes of this study were to investigate the IL-6-related inflammatory response to high-intensity interval exercise (HIIE) and to determine the impact of exercise intensity and volume on this response. Ten participants (5 males and 5 females) completed 3 exercise bouts of contrasting intensity and volume (LOW, MOD, and HIGH). The HIGH protocol was based upon standard HIIE protocols, while the MOD and LOW protocols were designed to enable a comparison of exercise intensity and volume with a fixed duration. Inflammatory cytokine concentrations were measured in plasma (IL-6, IL-10) and also determined the level of gene expression (IL-6, IL-10, and IL-4R) in peripheral blood. The plasma IL-6 response to exercise (reported as fold changes) was significantly greater in HIGH (2.70 ± 1.51) than LOW (1.40 ± 0.32) (P = 0.04) and was also positively correlated to the mean exercise oxygen uptake (r = 0.54, P < 0.01). However, there was no change in anti-inflammatory IL-10 or IL-4R responses in plasma or at the level of gene expression. HIIE caused a significant increase in IL-6 and was greater than that seen in low-intensity exercise of the same duration. The increases in IL-6 were relatively small in magnitude, and appear to have been insufficient to induce the acute systemic anti-inflammatory effects, which are evident following longer duration exercise.
authors.affiliation: a Cardiff School of Sport, Cardiff Metropolitan University, Cardiff CF23 6XD, UK.|b Institute of Sport & Exercise Science, University of Worcester, Henwick Grove, Worcester WR2 6AJ, UK.
authors.forename: Tom
authors.initials: T
authors.lastname: Cullen
authors.affiliation: c Cardiff School of Health Sciences, Cardiff Metropolitan University, Cardiff CF5 2YB, UK.
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Thomas
authors.affiliation: c Cardiff School of Health Sciences, Cardiff Metropolitan University, Cardiff CF5 2YB, UK.
authors.forename: Richard
authors.initials: R
authors.lastname: Webb
authors.affiliation: a Cardiff School of Sport, Cardiff Metropolitan University, Cardiff CF23 6XD, UK.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Hughes
mesh_terms: D000328:Adult; D004032:Diet; D015444:Exercise / Q000502:physiology*; D005260:Female; D005786:Gene Expression Regulation; D000072696:High-Intensity Interval Training; D006801:Humans; D016753:Interleukin-10 / Q000097:blood / Q000235:genetics; D015850:Interleukin-6 / Q000097:blood* / Q000235:genetics; D016014:Linear Models; D008297:Male; D010101:Oxygen Consumption; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D019947:Receptors, Interleukin-6 / Q000097:blood; D055815:Young Adult
chemical_list: C508609:IL10 protein, human; C508600:IL6 protein, human; C508603:IL6R protein, human; D015850:Interleukin-6; D012333:RNA, Messenger; D019947:Receptors, Interleukin-6; D016753:Interleukin-10
keywords: HIIT; anti-inflammatoires; anti-inflammatory; cytokines; exercice physique; exercise; high-intensity; intensité élevée; interval; intervalle