title: Association of GRIN2B gene polymorphism and Obsessive Compulsive disorder and symptom dimensions: A pilot study.
abstract: The etiology of OCD is largely unknown, but neuroimaging and pharmacological studies suggest that glutamatergic system plays a significant role on OCD development. We genotyped one polymorphism at GRIN2B (rs1019385) by real time Polymerase Chain Reaction in a sample of Brazilian Obsessive-Compulsive patients and healthy controls, and evaluated its influence on OCD. We found the T-allele and TT genotype to be significantly associated with OCD and ordering dimension. The T-allele was also significantly associated with checking. These preliminary results demonstrated that the GRIN2B gene may confer to some extent the susceptibility to OCD and its symptoms.
authors.affiliation: Departamento de Biologia Geral, Instituto de Biologia, Universidade Federal Fluminense (UFF), Niterói, Brazil. Electronic address: fabianabk@yahoo.com.
authors.forename: Fabiana Barzotti
authors.initials: FB
authors.lastname: Kohlrausch
authors.affiliation: Departamento de Biologia Geral, Instituto de Biologia, Universidade Federal Fluminense (UFF), Niterói, Brazil.
authors.forename: Isabele Gomes
authors.initials: IG
authors.lastname: Giori
authors.affiliation: Departamento de Biologia Geral, Instituto de Biologia, Universidade Federal Fluminense (UFF), Niterói, Brazil.
authors.forename: Fernanda Brito
authors.initials: FB
authors.lastname: Melo-Felippe
authors.affiliation: Departamento de Biologia Geral, Instituto de Biologia, Universidade Federal Fluminense (UFF), Niterói, Brazil.
authors.forename: Tamiris
authors.initials: T
authors.lastname: Vieira-Fonseca
authors.affiliation: Departamento de Estatística, Instituto de Matemática, Universidade Federal Fluminense (UFF), Niterói, Brazil.
authors.forename: Luis Guillermo Coca
authors.initials: LG
authors.lastname: Velarde
authors.affiliation: Programa de Transtornos Obsessivo-Compulsivos e de Ansiedade, Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil; Instituto D'Or de Pesquisa e Ensino (IDOR), Rio de Janeiro, Brazil.
authors.forename: Juliana Braga
authors.initials: JB
authors.lastname: de Salles Andrade
authors.affiliation: Programa de Transtornos Obsessivo-Compulsivos e de Ansiedade, Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil; Instituto D'Or de Pesquisa e Ensino (IDOR), Rio de Janeiro, Brazil; School of Psychological Sciences, MONASH University, Melbourne, Australia.
authors.forename: Leonardo Franklin
authors.initials: LF
authors.lastname: Fontenelle
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D001938:Brazil; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000235:genetics*; D010865:Pilot Projects; D011110:Polymorphism, Genetic; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics*; D055815:Young Adult
chemical_list: C121001:NR2B NMDA receptor; D016194:Receptors, N-Methyl-D-Aspartate
keywords: Brazil; Genetics; Symptom dimensions