title: The Topography of Cortical Microinfarcts in Neurodegenerative Diseases and in Vascular Dementia: A Postmortem 7.0-Tesla Magnetic Resonance Imaging Study.
abstract: Cortical microinfarcts (CoMIs) are considered as barely visible lesions in clinical-neuroradiological correlation studies. On postmortem 7.0-tesla MRI, however, CoMIs of different size are easily detected.
  
  
  
  The present MRI study investigates 84 postmortem brains with different neurodegenerative diseases and vascular dementia (VaD) for their topographic distribution and the prevalence of CoMIs. The mean numbers of CoMIs were determined on 6 hemispheric coronal sections and in 22 different gyri with a 7.0-tesla MRI Bruker BioSpin SA. A large coronal section at the level of the mammillary body was also used for neuropathological evaluation. CoMIs were predominantly observed in the prefrontal and postcentral sections of VaD brains. The mean number of CoMIs was significantly increased in the inferior frontal and in the cingulate gyri of VaD brains compared to the controls. No topographic differences were observed in the neurodegenerative diseases.
  
  
  
  As the inferior frontal and the cingulated gyri are areas frequently involved in VaD, CoMIs in those strategic locations must have an impact on the evolution of the vascular cognitive decline in those patients.
authors.affiliation: INSERM U1171, Universitx00E9; de Lille 2, Lille, France.
authors.forename: Jacques L
authors.initials: JL
authors.lastname: De Reuck
authors.forename: Florent
authors.initials: F
authors.lastname: Auger
authors.forename: Nicolas
authors.initials: N
authors.lastname: Durieux
authors.forename: Charlotte
authors.initials: C
authors.lastname: Cordonnier
authors.forename: Vincent
authors.initials: V
authors.lastname: Deramecourt
authors.forename: Florence
authors.initials: F
authors.lastname: Pasquier
authors.forename: Claude-Alain
authors.initials: CA
authors.lastname: Maurage
authors.forename: Didier
authors.initials: D
authors.lastname: Leys
authors.forename: Regis
authors.initials: R
authors.lastname: Bordet
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D020520:Brain Infarction / Q000000981:diagnostic imaging / Q000473:pathology*; D015140:Dementia, Vascular / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D019636:Neurodegenerative Diseases / Q000000981:diagnostic imaging / Q000473:pathology*