title: Orosomucoid is an independent predictor of prognosis in chronic heart failure.
abstract: BACKGROUND
  Heart failure is associated with low-grade inflammation. In the present study we sought to assess the prognostic impact of orosomucoid, a marker of inflammation, in outpatients with heart failure.
  
  
  METHODS
  In outpatients with chronic heart failure (no change in clinical status and/or therapy >3 months prior to inclusion), baseline levels of orosomucoid were determined. Clinical follow-up was obtained and the rate of heart failure-related deaths and hospitalisations recorded.
  
  
  RESULTS
  A total of 134 patients (median age 71, 33.3 % female, mean left ventricular ejection fraction [LVEF] 36 %) were included. During a median follow-up of 695 (456-811) days, 54 patients (40.1 %) experienced an event. On Cox multivariate analysis, orosomucoid levels above the median (>497 mg/l) emerged as an independent predictor of prognosis (hazard ratio = 2.86, 95 % confidence interval 1.48-5.52 after adjusting for age, gender, ischaemic vs. non-ischaemic aetiology, LVEF, NT-proBNP and NYHA class).
  
  
  CONCLUSIONS
  Orosomucoid levels are an independent predictor of heart failure-related mortality and hospitalisations in patients with chronic heart failure.
authors.affiliation: , Ljubljana, Slovenia. petrakaplan@gmail.com.
authors.forename: Petra
authors.initials: P
authors.lastname: Kaplan
authors.affiliation: , Ljubljana, Slovenia.
authors.forename: Bojan
authors.initials: B
authors.lastname: Vrtovec
authors.affiliation: , Ljubljana, Slovenia.
authors.forename: Borut
authors.initials: B
authors.lastname: Jug
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000175:diagnosis / Q000401:mortality*; D006801:Humans; D008297:Male; D009961:Orosomucoid / Q000032:analysis*; D015995:Prevalence; D011379:Prognosis; D015203:Reproducibility of Results; D012307:Risk Factors; D012680:Sensitivity and Specificity; D017524:Slovenia / Q000453:epidemiology; D015996:Survival Rate
chemical_list: D015415:Biomarkers; D009961:Orosomucoid
keywords: Biomarker; Heart failure; Inflammation; Orosomucoid; Risk prediction