title: The Association between Symptoms of Dry Eye Syndrome and Metabolic Outcome in a General Population in Korea.
abstract: Dry eye syndrome (DES) is recognized as a public health concern. One of the pathophysiologies in the development of DES is inflammation, and metabolic syndrome (MetS), which is highly prevalent in the general population, is a well-known chronic and systemic inflammatory condition. Despite the increasing interest regarding a relationship between DES and MetS, information is lacking on the association between DES and MetS and its individual components. We investigated the association between DES symptoms and MetS and its components among adults aged ≥ 19 years using population-based data from the Korea National Health and Nutrition Examination Survey V. A sample group of 15,294 adults (42.67% men and 57.33% women) completed household interviews in which they provided blood (for high-density lipoprotein cholesterol, triglyceride, and glucose) and anthropometric measurements (including waist circumference, weight, and height) to define MetS. We also collected information regarding sociodemographic and behavioral risk factors. The survey results showed that 11.50% of men and 22.35% of women experienced DES and 5.30% of patients had both DES and diagnosis of MetS, including 204 men and 606 women. Thus, no significant difference was observed between DES and the diagnosis of MetS according to sex (P = 0.4008 in men; P = 0.0804 in women); however, a significant association was observed between DES and hypertriglyceridemia in women (OR, 1.13; 95% CI, 1.01-1.29). Therefore, hypertriglyceridemia might be an important factor in the association between DES and MetS. Further longitudinal research is needed to evaluate this relationship.
authors.affiliation: Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea.; Department of Ophthalmology, National Health Insurance Service Ilsan Hospital, Goyang, Korea.
authors.forename: Hye Won
authors.identifier: 0000-0001-8885-4032
authors.initials: HW
authors.lastname: Park
authors.affiliation: Department of Ophthalmology, National Health Insurance Service Ilsan Hospital, Goyang, Korea .
authors.forename: Jong Woon
authors.identifier: 0000-0001-8992-862X
authors.initials: JW
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D001827:Body Height; D001835:Body Weight; D008076:Cholesterol, HDL / Q000097:blood; D003430:Cross-Sectional Studies; D015352:Dry Eye Syndromes / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000150:complications / Q000175:diagnosis; D007407:Interviews as Topic; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D008875:Middle Aged; D009749:Nutrition Surveys; D015995:Prevalence; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D014280:Triglycerides
keywords: Adult; Dry Eye Syndrome; Korea; Metabolic Syndrome; National Health and Nutrition Examination Survey; Population