title: The effect of multivitamin-multimineral supplementation on the health status of inbred Wistar and spontaneously hypertensive rat strains.
abstract: The nutraceutical industry has proliferated in recent years, with the most popular form of supplementation being the multivitamin-multimineral (MVMM) supplement. In the animal health sector, supplement use has also expanded. The objective of this study was to determine the effects of MVMM supplementation, beneficial or otherwise, on the general health status of the spontaneously hypertensive rat (SHR) strain, an animal model used in hypertension research. A commercially prepared MVMM supplement was given tri-weekly via oral dosing for 8 weeks to two groups of seven adult female SHR and Wistar rats. Their corresponding control groups were dosed with deionised water only. Systolic and diastolic blood pressure, fasting blood glucose, growth rate and food and water intake were measured weekly. At the end of 8 weeks, the animals were euthanased and a full blood profile, urine sodium to potassium ratio, blood urea nitrogen levels and total plasma cholesterol was measured for all groups. The results indicated that growth rate was higher for the SHR supplemented group. Supplementation also decreased diastolic blood pressure in both Wistar and SHR groups and increased red blood cell count and decreased total cholesterol in the SHR group. No adverse effects on the general health status of the animals were observed. MVMM supplementation may therefore be useful in aiding growth and delaying the onset of hypertension and its effects. It may also assist in the longevity of the breeding stock of SHR rats.
authors.affiliation: School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Westville Campus. hoflerrose@gmail.com.
authors.forename: Rosemarie U
authors.initials: RU
authors.lastname: Höfler
authors.forename: Mahendra L
authors.initials: ML
authors.lastname: Channa
authors.forename: Anand
authors.initials: A
authors.lastname: Nadar
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D049628:Body Size; D015331:Cohort Studies; D003300:Copper / Q000008:administration & dosage; D019587:Dietary Supplements / Q000592:standards*; D004326:Drinking; D004435:Eating; D005215:Fasting; D005260:Female; D006304:Health Status; D006400:Hematocrit / Q000662:veterinary; D006454:Hemoglobins / Q000032:analysis; D018655:Lymphocyte Count / Q000662:veterinary; D008903:Minerals / Q000008:administration & dosage*; D053758:Nanoparticles; D051381:Rats; D011918:Rats, Inbred SHR / Q000097:blood / Q000254:growth & development / Q000502:physiology*; D017208:Rats, Wistar / Q000097:blood / Q000254:growth & development / Q000502:physiology*; D014554:Urination; D014815:Vitamins / Q000008:administration & dosage*
chemical_list: D001786:Blood Glucose; D006454:Hemoglobins; D008903:Minerals; D014815:Vitamins; D003300:Copper
keywords: multivitamin-multimineral (MVMM) supplementation; hypertension; spontaneously hypertensive rats (BRU); Wistar rats; breeding stock.