title: Psychological mediators of chronic tinnitus: The critical role of depression.
abstract: Maintenance of chronic tinnitus has been proposed to result from a vicious cycle of hypervigilance occurring when a phantom sound is associated with anxiety and limbic system overactivity. Depression, obsessive-compulsiveness, illness attitudes and coping strategies are known to impact tinnitus, but their relationship with the vicious cycle is unknown. As such, we aimed to identify psychological mediators of the vicious cycle. We also examined the relationship between coping strategies and any identified mediators to facilitate the translation of our research to treatment settings.
  
  
  
  We comprehensively assessed a heterogeneous community sample of 81 people with chronic tinnitus who completed measures assessing their tinnitus and psychological wellbeing. Specifically, we examined the mediating role of depressive symptoms, illness attitudes, and obsessive-compulsiveness in the vicious cycle.
  
  
  
  While the predicted relationship between tinnitus handicap and anxiety was observed, this was fully mediated by depressive symptoms. In addition, we identified avoidant behaviours and self-blame as maladaptive coping strategies in people with chronic tinnitus and depressive symptoms, identifying potential new treatment targets.
  
  
  
  This work requires replication in a clinical cohort of people with chronic tinnitus, and further investigations of the role of coping strategies.
  
  
  
  These results extend our understanding of the complex role of psychology in the experience of tinnitus, highlighting the importance of depressive symptoms that may be underpinned by functional disruption of specific neurocognitive networks. We have also identified depressive symptoms and maladaptive coping strategies as new treatment targets to improve the health wellbeing of people with chronic tinnitus.
authors.affiliation: Psychological Sciences, The University of Melbourne, Victoria, Australia. Electronic address: kjtrevis@gmail.com.
authors.forename: Krysta J
authors.initials: KJ
authors.lastname: Trevis
authors.affiliation: Psychological Sciences, The University of Melbourne, Victoria, Australia.
authors.forename: Neil M
authors.initials: NM
authors.lastname: McLachlan
authors.affiliation: Psychological Sciences, The University of Melbourne, Victoria, Australia.
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Wilson
mesh_terms: D000223:Adaptation, Psychological; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001007:Anxiety / Q000523:psychology; D001362:Avoidance Learning; D002908:Chronic Disease; D015331:Cohort Studies; D003863:Depression / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014012:Tinnitus / Q000523:psychology*; D055815:Young Adult
keywords: Anxiety; Chronic tinnitus; Depression; Neurocognitive networks