title: IVF outcomes in average- and poor-prognosis infertile women according to the number of embryos transferred.
abstract: Outcome measures of IVF success, which account for effectiveness of IVF and perinatal outcome risks, have recently been described. The association between number of embryos transferred in average and poor-prognosis IVF patients, and the chances of having good or poor IVF and perinatal outcomes, was investigated. Good IVF and perinatal outcome was defined as the birth of a live, term, normal-weight infant (≥2500 g). Poor IVF and perinatal outcome was defined as no live birth or birth of a very low weight neonate (<1500 g) or severe prematurity (birth at <32 weeks gestation). Each neonate was analysed as a separate outcome. A total of 713 IVF cycles in 504 average and poor-prognosis patients from January 2010 to December 2013 were identified. The odds of having good IVF and perinatal outcomes increased by 28% for each additional embryo transferred. The odds of poor IVF and perinatal outcome decreased by 32% with an additional embryo transferred. The likelihood of live birth with good perinatal outcome in average- and poor-prognosis patients after IVF increases with additional embryos being transferred. These data add to recently reported evidence in favour of multiple embryo transfer in older women and those with average or poor IVF prognosis.
authors.affiliation: The Center for Human Reproduction, New York, NY 10021, USA; Department of Obstetrics and Gynecology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
authors.forename: Mario G
authors.initials: MG
authors.lastname: Vega
authors.affiliation: The Center for Human Reproduction, New York, NY 10021, USA; The Foundation for Reproductive Medicine, New York, NY 10021, USA; Stem Cell Biology and Molecular Embryology Laboratory, The Rockefeller University, New York, NY 10065-6399, USA.
authors.forename: Norbert
authors.initials: N
authors.lastname: Gleicher
authors.affiliation: The Center for Human Reproduction, New York, NY 10021, USA.
authors.forename: Sarah K
authors.initials: SK
authors.lastname: Darmon
authors.affiliation: The Center for Human Reproduction, New York, NY 10021, USA; Vienna University School of Medicine, Vienna 1090, Austria.
authors.forename: Andrea
authors.initials: A
authors.lastname: Weghofer
authors.affiliation: The Center for Human Reproduction, New York, NY 10021, USA.
authors.forename: Yan-Guang
authors.initials: YG
authors.lastname: Wu
authors.affiliation: The Center for Human Reproduction, New York, NY 10021, USA.
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.affiliation: The Center for Human Reproduction, New York, NY 10021, USA.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.affiliation: The Center for Human Reproduction, New York, NY 10021, USA; Department of Molecular and Integrative Physiology, The University of Kansas School of Medicine, Kansas City, KS 66160, USA.
authors.forename: David F
authors.initials: DF
authors.lastname: Albertini
authors.affiliation: The Center for Human Reproduction, New York, NY 10021, USA; Department of Obstetrics and Gynecology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Stem Cell Biology and Molecular Embryology Laboratory, The Rockefeller University, New York, NY 10065-6399, USA.
authors.forename: David H
authors.initials: DH
authors.lastname: Barad
authors.affiliation: The Center for Human Reproduction, New York, NY 10021, USA; Department of Obstetrics and Gynecology, Wake Forest University, Winston Salem, NC 27106, USA. Electronic address: vkushnir@thechr.com.
authors.forename: Vitaly A
authors.initials: VA
authors.lastname: Kushnir
mesh_terms: D000328:Adult; D000367:Age Factors; D004624:Embryo Transfer / Q000379:methods*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D008423:Maternal Age; D016017:Odds Ratio; D011247:Pregnancy; D018873:Pregnancy Rate; D011379:Prognosis; D016896:Treatment Outcome
keywords: IVF; perinatal outcomes; poor prognosis patients; poor responders