title: Rapamycin/DiR loaded lipid-polyaniline nanoparticles for dual-modal imaging guided enhanced photothermal and antiangiogenic combination therapy.
abstract: Imaging-guided photothermal therapy (PTT) has promising application for treating tumors. Nevertheless, so far imaging-guided photothermal drug-delivery systems have been developed with limited success for tumor chemo-photothermal therapy. In this study, as the proof-of-concept, a stimuli-responsive tumor-targeting rapamycin/DiR loaded lipid-polyaniline nanoparticle (RDLPNP) for dual-modal imaging-guided enhanced PTT efficacy is reported for the first time. In this system, polyaniline (PANI) with π-π electronic conjugated system and effective photothermal efficiency is chosen as the appropriate model receptor of fluorescence resonance energy transfer (FRET), and loaded cyanine probe (e.g., 1,1-dioctadecyl-3,3,3,3-tetramethylindotricarbocyanine iodide, DiR) acts as the donor of near-infrared fluorescence (NIRF). In addition, rapamycin (RAPA), which is used as the antiangiogenesis chemotherapeutic drug, can cutdown the tumor vessels and delay tumor growth obviously. After intravenous treatment of RDLPNPs into Hela tumor bearing mice, fluorescent (from DiR) and enhanced photoacoustic (from DLPNPs) signals were found in tumor site over time, which reached to peak at the 6h time point. After irradiating with an NIR laser, a good anti-tumor effect was observed owing to the enhanced photothermal and antiangiogenic effect of RDLPNPs. These results show that the multifunctional nanoparticle can be used as a promising imaging-guided photothermal drug delivery nanoplatform for cancer therapy.
authors.affiliation: Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, PR China.
authors.forename: Jinping
authors.initials: J
authors.lastname: Wang
authors.affiliation: Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, PR China.
authors.forename: Fang
authors.initials: F
authors.lastname: Guo
authors.affiliation: Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, PR China.
authors.forename: Meng
authors.initials: M
authors.lastname: Yu
authors.affiliation: Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.affiliation: Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, PR China.
authors.forename: Fengping
authors.initials: F
authors.lastname: Tan
authors.affiliation: Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom. Electronic address: ran.yan@kcl.ac.uk.
authors.forename: Ran
authors.initials: R
authors.lastname: Yan
authors.affiliation: Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, PR China. Electronic address: linan19850115@163.com.
authors.forename: Nan
authors.initials: N
authors.lastname: Li
mesh_terms: D020533:Angiogenesis Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D000814:Aniline Compounds / Q000737:chemistry*; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use*; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D005260:Female; D006367:HeLa Cells; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D051379:Mice; D008807:Mice, Inbred BALB C; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy*; D061848:Optical Imaging / Q000379:methods; D061088:Photoacoustic Techniques / Q000379:methods; D010789:Phototherapy / Q000379:methods; D020123:Sirolimus / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D020533:Angiogenesis Inhibitors; D000814:Aniline Compounds; D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; C416807:polyaniline; D020123:Sirolimus
keywords: Antiangiogenesis; Enhanced photothermal therapy; Imaging-guided therapy; Lipid-polyaniline nanoparticles; Rapamycin