title: Regulation of Stress Responses and Translational Control by Coronavirus.
abstract: Similar to other viruses, coronavirus infection triggers cellular stress responses in infected host cells. The close association of coronavirus replication with the endoplasmic reticulum (ER) results in the ER stress responses, which impose a challenge to the viruses. Viruses, in turn, have come up with various mechanisms to block or subvert these responses. One of the ER stress responses is inhibition of the global protein synthesis to reduce the amount of unfolded proteins inside the ER lumen. Viruses have evolved the capacity to overcome the protein translation shutoff to ensure viral protein production. Here, we review the strategies exploited by coronavirus to modulate cellular stress response pathways. The involvement of coronavirus-induced stress responses and translational control in viral pathogenesis will also be briefly discussed.
authors.affiliation: School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore. tosingfung@163.com.
authors.forename: To Sing
authors.initials: TS
authors.lastname: Fung
authors.affiliation: Department of Avian Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Ziyue Road 518, Shanghai 200241, China. liaoying@shvri.ac.cn.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liao
authors.affiliation: School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore. dxliu0001@163.com.
authors.forename: Ding Xiang
authors.initials: DX
authors.lastname: Liu
mesh_terms: D000818:Animals; D017934:Coronavirus / Q000472:pathogenicity*; D059865:Endoplasmic Reticulum Stress; D054884:Host-Pathogen Interactions; D006801:Humans; D014176:Protein Biosynthesis; D013312:Stress, Physiological; D014764:Viral Proteins / Q000096:biosynthesis*
chemical_list: D014764:Viral Proteins
keywords: ER stress; GADD34/PP1; JNK; PERK; PKR; coronavirus; eIF2α; nsp1; p38; translational control; unfolded protein response