title: Pharmacological protection of mitochondrial function mitigates acute limb ischemia/reperfusion injury.
abstract: We describe several novel curcumin analogues that possess both anti-inflammatory antioxidant properties and thrombolytic activities. The therapeutic efficacy of these curcumin analogues was verified in a mouse ear edema model, a rat arterial thrombosis assay, a free radical scavenging assay performed in PC12 cells, and in both in vitro and in vivo ischemia/reperfusion models. Our findings suggest that their protective effects partially reside in maintenance of optimal mitochondrial function.
authors.affiliation: Second Hospital of HeBei Medical University, Shijiazhuang, HeBei 050000, PR China. Electronic address: biwei@hb2h.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Bi
authors.affiliation: Second Hospital of HeBei Medical University, Shijiazhuang, HeBei 050000, PR China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Bi
authors.affiliation: Department of Chemistry, Michigan Technological University, Houghton, MI 49931, USA.
authors.forename: Xiang
authors.initials: X
authors.lastname: Gao
authors.affiliation: Department of Chemistry, Michigan Technological University, Houghton, MI 49931, USA.
authors.forename: Xin
authors.initials: X
authors.lastname: Yan
authors.affiliation: Second Hospital of HeBei Medical University, Shijiazhuang, HeBei 050000, PR China.
authors.forename: Yanrong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, Michigan Technological University, Houghton, MI 49931, USA.
authors.forename: Jackie
authors.initials: J
authors.lastname: Harris
authors.affiliation: Marquette General Heart and Vascular Institute, Marquette General Hospital, Marquette, MI 49855, USA.
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Legalley
authors.affiliation: Section of Experimental and Systems Pharmacology, College of Pharmacy, Washington State University, Spokane, WA 99202, USA. Electronic address: mike.gibson@wsu.edu.
authors.forename: K Michael
authors.initials: KM
authors.lastname: Gibson
authors.affiliation: Department of Chemistry, Michigan Technological University, Houghton, MI 49931, USA. Electronic address: lanrong@mtu.edu.
authors.forename: Lanrong
authors.initials: L
authors.lastname: Bi
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D003474:Curcumin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D045304:Cytochromes c / Q000378:metabolism; D004195:Disease Models, Animal; D004487:Edema / Q000517:prevention & control; D004797:Enzyme-Linked Immunosorbent Assay; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D061307:Human Umbilical Vein Endothelial Cells; D015850:Interleukin-6 / Q000097:blood; D051379:Mice; D008856:Microscopy, Fluorescence; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects; D016716:PC12 Cells; D011789:Quantum Theory; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism; D015427:Reperfusion Injury / Q000188:drug therapy / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D000893:Anti-Inflammatory Agents; D016166:Free Radical Scavengers; D015850:Interleukin-6; D017382:Reactive Oxygen Species; D014409:Tumor Necrosis Factor-alpha; D045304:Cytochromes c; D003474:Curcumin
keywords: Anti-inflammatory activity; Curcumin analogues; Free radical scavenging activity; Ischemia/reperfusion injury; Thrombolytic activity