title: Factors influencing the ablative efficiency of high intensity focused ultrasound (HIFU) treatment for adenomyosis: A retrospective study.
abstract: Objectives The aim of this study was to investigate factors affecting ablative efficiency of high intensity focused ultrasound (HIFU) for adenomyosis. Materials and methods In all, 245 patients with adenomyosis who underwent ultrasound guided HIFU (USgHIFU) were retrospectively reviewed. All patients underwent dynamic contrast-enhanced magnetic resonance imaging (MRI) before and after HIFU treatment. The non-perfused volume (NPV) ratio, energy efficiency factor (EEF) and greyscale change were set as dependent variables, while the factors possibly affecting ablation efficiency were set as independent variables. These variables were used to build multiple regression models. Results A total of 245 patients with adenomyosis successfully completed HIFU treatment. Enhancement type on T1 weighted image (WI), abdominal wall thickness, volume of adenomyotic lesion, the number of hyperintense points, location of the uterus, and location of adenomyosis all had a linear relationship with the NPV ratio. Distance from skin to the adenomyotic lesion's ventral side, enhancement type on T1WI, volume of adenomyotic lesion, abdominal wall thickness, and signal intensity on T2WI all had a linear relationship with EEF. Location of the uterus and abdominal wall thickness also both had a linear relationship with greyscale change. Conclusion The enhancement type on T1WI, signal intensity on T2WI, volume of adenomyosis, location of the uterus and adenomyosis, number of hyperintense points, abdominal wall thickness, and distance from the skin to the adenomyotic lesion's ventral side can all be used as predictors of HIFU for adenomyosis.
authors.affiliation: a State Key Laboratory of Ultrasound Engineering in Medicine, Chongqing and the Ministry of Science and Technology, Chongqing Key Laboratory of Ultrasound in Medicine and Engineering , College of Biomedical Engineering, Chongqing Medical University , Chongqing , China ;
authors.forename: Chunmei
authors.initials: C
authors.lastname: Gong
authors.affiliation: b Department of Obstetrics and Gynaecology , Fourth Division Hospital of Xinjiang Production and Construction Corps , Yining , Xinjiang , China.
authors.forename: Bin
authors.initials: B
authors.lastname: Yang
authors.affiliation: b Department of Obstetrics and Gynaecology , Fourth Division Hospital of Xinjiang Production and Construction Corps , Yining , Xinjiang , China.
authors.forename: Yarong
authors.initials: Y
authors.lastname: Shi
authors.affiliation: a State Key Laboratory of Ultrasound Engineering in Medicine, Chongqing and the Ministry of Science and Technology, Chongqing Key Laboratory of Ultrasound in Medicine and Engineering , College of Biomedical Engineering, Chongqing Medical University , Chongqing , China ;
authors.forename: Zhongqiong
authors.initials: Z
authors.lastname: Liu
authors.affiliation: a State Key Laboratory of Ultrasound Engineering in Medicine, Chongqing and the Ministry of Science and Technology, Chongqing Key Laboratory of Ultrasound in Medicine and Engineering , College of Biomedical Engineering, Chongqing Medical University , Chongqing , China ;
authors.forename: Lili
authors.initials: L
authors.lastname: Wan
authors.affiliation: b Department of Obstetrics and Gynaecology , Fourth Division Hospital of Xinjiang Production and Construction Corps , Yining , Xinjiang , China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.affiliation: b Department of Obstetrics and Gynaecology , Fourth Division Hospital of Xinjiang Production and Construction Corps , Yining , Xinjiang , China.
authors.forename: Denghua
authors.initials: D
authors.lastname: Jiang
authors.affiliation: a State Key Laboratory of Ultrasound Engineering in Medicine, Chongqing and the Ministry of Science and Technology, Chongqing Key Laboratory of Ultrasound in Medicine and Engineering , College of Biomedical Engineering, Chongqing Medical University , Chongqing , China ;
authors.forename: Lian
authors.initials: L
authors.lastname: Zhang
mesh_terms: D062788:Adenomyosis / Q000000981:diagnostic imaging / Q000601:surgery*; D000328:Adult; D005260:Female; D057086:High-Intensity Focused Ultrasound Ablation; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009215:Myometrium / Q000000981:diagnostic imaging / Q000601:surgery; D016896:Treatment Outcome; D014463:Ultrasonography; D055815:Young Adult
keywords: Ablative efficiency; adenomyosis; high intensity focused ultrasound (HIFU); magnetic resonance imaging (MRI)