title: Myocardial Ischemia: Lack of Coronary Blood Flow or Myocardial Oxygen Supply/Demand Imbalance?
abstract: Regional myocardial blood flow and contractile function in ischemic myocardium are well matched, and there is no evidence for an oxygen supply/demand imbalance. Thus, myocardial ischemia is lack of coronary blood flow with electric, functional, metabolic, and structural consequences for the myocardium. All therapeutic interventions must aim to improve blood flow to ischemic myocardium as much and as quickly as possible.
authors.affiliation: From the Institute for Pathophysiology, West German Heart and Vascular Center, University of Essen Medical School, Essen, Germany. gerd.heusch@uk-essen.de.
authors.forename: Gerd
authors.initials: G
authors.lastname: Heusch
mesh_terms: D000818:Animals; D003326:Coronary Circulation / Q000502:physiology*; D006801:Humans; D017202:Myocardial Ischemia / Q000175:diagnosis / Q000378:metabolism* / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism*; D010101:Oxygen Consumption / Q000502:physiology*
keywords: coronary stenosis; ischemia; myocardium