title: Emerging roles for the novel estrogen-sensing receptor GPER1 in the CNS.
abstract: Estrogens play a key role in regulating reproductive and neuroendocrine function by activating classical nuclear steroid receptors that act as ligand gated transcription factors. However evidence is growing that estrogens also promote rapid non-genomic responses via activation of membrane-associated estrogen receptors. The G protein-coupled estrogen receptor (GPER1; also known as GPR30) has been identified as one of the main estrogen-sensitive receptors responsible for the rapid non-genomic actions of estrogen. In recent years, our understanding of the CNS actions of GPER1s has significantly increased following the development of selective pharmacological tools and via the use of transgenic technologies to knockout GPER1 in mice. Here we review recent advances that have been made to uncover the role of GPER1s in the CNS. This article is part of the Special Issue entitled 'Lipid Sensing G Protein-Coupled Receptors in the CNS'.
authors.affiliation: Division of Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, Scotland, UK.
authors.forename: Amy
authors.initials: A
authors.lastname: Alexander
authors.affiliation: School of Biomolecular and Biomedical Science, The Conway Institute, UCD, Belfield, Dublin D4, Ireland.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Irving
authors.affiliation: Division of Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, Scotland, UK. Electronic address: j.z.harvey@dundee.ac.uk.
authors.forename: Jenni
authors.initials: J
authors.lastname: Harvey
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D004967:Estrogens / Q000378:metabolism; D006801:Humans; D011960:Receptors, Estrogen / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*
chemical_list: D004967:Estrogens; D011960:Receptors, Estrogen; D043562:Receptors, G-Protein-Coupled
keywords: G protein coupled estrogen receptor; Hippocampal synaptic function; Learning and memory; Neuroprotection; Receptor trafficking; Synaptic plasticity