title: Immune-based guidance of foscarnet treatment duration in a transplant recipient with ganciclovir-resistant cytomegalovirus infection.
abstract: A lung and kidney transplant recipient underwent cytomegalovirus (CMV) primary infection with a UL97 mutation. Combined monitoring of viral load and CMV-specific CD4 T-cells allowed reduction of treatment duration with foscarnet, and illustrates how knowledge on the individual immunocompetence towards CMV may be used to individualize duration of antiviral treatment.
authors.affiliation: Department of Internal Medicine IV, Saarland University, D-66421 Homburg, Germany.
authors.forename: Janine
authors.initials: J
authors.lastname: Mihm
authors.affiliation: Department of Internal Medicine IV, Saarland University, D-66421 Homburg, Germany.
authors.forename: Sarah
authors.initials: S
authors.lastname: Leyking
authors.affiliation: Department of Transplant and Infection Immunology, Saarland University, D-66421 Homburg, Germany.
authors.forename: Jan
authors.initials: J
authors.lastname: Dirks
authors.affiliation: Institute of Virology, Saarland University, D-66421 Homburg, Germany.
authors.forename: Sigrun
authors.initials: S
authors.lastname: Smola
authors.affiliation: Department of Internal Medicine IV, Saarland University, D-66421 Homburg, Germany.
authors.forename: Danilo
authors.initials: D
authors.lastname: Fliser
authors.affiliation: Department of Internal Medicine IV, Saarland University, D-66421 Homburg, Germany.
authors.forename: Urban
authors.initials: U
authors.lastname: Sester
authors.affiliation: Department of Transplant and Infection Immunology, Saarland University, D-66421 Homburg, Germany. Electronic address: martina.sester@uks.eu.
authors.forename: Martina
authors.initials: M
authors.lastname: Sester
authors.affiliation: Department of Internal Medicine V, Saarland University, D-66421 Homburg, Germany.
authors.forename: Heinrike
authors.initials: H
authors.lastname: Wilkens
authors.affiliation: Institute of Virology, Saarland University, D-66421 Homburg, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Rissland
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage* / Q000494:pharmacology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D003587:Cytomegalovirus / Q000187:drug effects*; D003586:Cytomegalovirus Infections / Q000188:drug therapy* / Q000821:virology; D016903:Drug Monitoring / Q000379:methods*; D024882:Drug Resistance, Viral; D005260:Female; D017245:Foscarnet / Q000008:administration & dosage*; D015774:Ganciclovir / Q000494:pharmacology; D006801:Humans; D016030:Kidney Transplantation; D016040:Lung Transplantation; D066027:Transplant Recipients; D019562:Viral Load
chemical_list: D000998:Antiviral Agents; D017245:Foscarnet; D015774:Ganciclovir
keywords: Antiviral therapy; Cytomegalovirus; Resistance; Solid organ transplantation; T-cell