title: Subcutaneous Angioleiomyoma: Clinical and Sonographic Features With Histopathologic Correlation.
abstract: OBJECTIVE
  To investigate clinical and sonographic features of subcutaneous angioleiomyoma with histopathologic correlation.
  
  
  METHODS
  Clinical features of 141 cases and sonographic appearances of 33 cases of histopathologically proven subcutaneous angioleiomyoma were retrospectively reviewed. Clinical information included patient age, sex, tumor location, and symptoms. Sonographic features included tumor size, location, contour, margin, component, echogenicity, calcifications, and vascularity. Sonograms were analyzed with histopathologic correlation by a single radiologist and a single pathologist.
  
  
  RESULTS
  Clinical features of the 141 cases of angioleiomyoma included the following: 78.0% of the cases (110 of 141) were on the lower leg or ankle; 55.3% of the patients (78 of 141) had pain at the tumor location; the female-to-male ratio was 1.61:1.00, and most cases occurred in patients in the third through sixth decades. Sonographic features of the 33 cases of angioleiomyoma included the following: 85.0% of the cases (28 of 33) were smaller than 20 mm; 94.0% to 97.0% were solid, oval, parallel to the skin, well defined, and homogeneously hypoechoic and without calcifications; 75.8% (25 of 33) were superficially located, close to or in contact with the dermis; and 39.4% (13 of 33) showed low or moderate internal vascularity.
  
  
  CONCLUSIONS
  Typical clinical and sonographic features of angioleiomyoma may include a female patient with a painful lower leg or ankle subcutaneous mass, a superficial location, especially in contact with the dermis, a small size (<20 mm), an oval shape, a parallel orientation to the skin, well-defined margins, complete solid components, homogeneous hypoechogenicity, low or moderate vascular density, and absence of calcifications.
authors.affiliation: Department of Ultrasound in Medicine, Shanghai Institute of Ultrasound in Medicine jason_zhangjizhen@163.com.
authors.forename: Ji-Zhen
authors.initials: JZ
authors.lastname: Zhang
authors.affiliation: Department of Pathology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
authors.forename: Zhi-Chang
authors.initials: ZC
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018229:Angiomyoma / Q000000981:diagnostic imaging* / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009372:Neoplasms, Connective Tissue / Q000000981:diagnostic imaging* / Q000473:pathology*; D012189:Retrospective Studies; D014463:Ultrasonography / Q000379:methods*; D055815:Young Adult
keywords: angioleiomyoma; musculoskeletal ultrasound; soft tissue mass; sonography; vascular leiomyoma