title: [Rapid detection of antimicrobial resistance by MALDI-TOF mass spectrometry].
abstract: In recent years, MALDI-TOF (matrix-assisted laser desorption ionization time-of-flight) mass spectrometry has become established as a first-line diagnostic tool in the identification of microorganisms, including those producing human infections. Rapid detection of antimicrobial resistance is one of the future applications of this technique with the greatest likelihood of success. This review describes the most important studies published in this field and discusses potential future challenges and the clinical application of this technique in the next few years.
authors.affiliation: Complejo Hospitalario Universitario A Coruña, A Coruña, España.
authors.forename: Marina
authors.initials: M
authors.lastname: Oviaño
authors.affiliation: Complejo Hospitalario Universitario de Granada, Granada, España.
authors.forename: María
authors.initials: M
authors.lastname: Dolores Rojo
authors.affiliation: Complejo Hospitalario Universitario de Granada, Granada, España.
authors.forename: José María
authors.initials: JM
authors.lastname: Navarro Marí
authors.affiliation: Complejo Hospitalario Universitario A Coruña, A Coruña, España. Electronic address: german.bou.arevalo@sergas.es.
authors.forename: Germán
authors.initials: G
authors.lastname: Bou
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects / Q000201:enzymology; D001426:Bacterial Proteins / Q000032:analysis; D024881:Drug Resistance, Bacterial; D025141:Drug Resistance, Fungal; D005544:Forecasting; D005656:Fungal Proteins / Q000032:analysis; D006801:Humans; D007553:Isotope Labeling; D008826:Microbial Sensitivity Tests / Q000295:instrumentation / Q000379:methods*; D017422:Sequence Analysis, DNA / Q000379:methods; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*; D015003:Yeasts / Q000187:drug effects / Q000201:enzymology
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D005656:Fungal Proteins
keywords: Detección rápida; Espectrometría de masas; MALDI-TOF; Mass spectrometry; Mecanismos de resistencia; Rapid detection; Resistance mechanisms