title: The RNA binding protein HuR determines the differential translation of autism-associated FoxP subfamily members in the developing neocortex.
abstract: Forkhead-box domain (Fox) containing family members are known to play a role in neocorticogenesis and have also been associated with disorders on the autism spectrum. Here we show that a single RNA-binding protein, Hu antigen R (HuR), dictates translation specificity of bound mRNAs and is sufficient to define distinct Foxp-characterized subpopulations of neocortical projection neurons. Furthermore, distinct phosphorylation states of HuR differentially regulate translation of Foxp mRNAs in vitro. This demonstrates the importance of RNA binding proteins within the framework of the developing brain and further confirms the role of mRNA translation in autism pathogenesis.
authors.affiliation: Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway 08854, NJ, USA.
authors.forename: T
authors.initials: T
authors.lastname: Popovitchenko
authors.affiliation: Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway 08854, NJ, USA.
authors.forename: K
authors.initials: K
authors.lastname: Thompson
authors.affiliation: Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway 08854, NJ, USA.
authors.forename: B
authors.initials: B
authors.lastname: Viljetic
authors.affiliation: Department of Cell Biology and Neuroscience, Rutgers University, Piscataway 08854, NJ, USA.
authors.forename: X
authors.initials: X
authors.lastname: Jiao
authors.affiliation: Institute of Immunology, Biomedical Sciences Research Center Alexander Fleming, Vari, Greece.
authors.forename: D L
authors.initials: DL
authors.lastname: Kontonyiannis
authors.affiliation: Department of Cell Biology and Neuroscience, Rutgers University, Piscataway 08854, NJ, USA.
authors.forename: M
authors.initials: M
authors.lastname: Kiledjian
authors.affiliation: Department of Cell Biology and Neuroscience, Rutgers University, Piscataway 08854, NJ, USA.
authors.forename: R P
authors.initials: RP
authors.lastname: Hart
authors.affiliation: Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway 08854, NJ, USA.
authors.forename: M R
authors.initials: MR
authors.lastname: Rasin
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics; D000818:Animals; D000067877:Autism Spectrum Disorder / Q000235:genetics; D047369:Chromatin Immunoprecipitation; D000067780:ELAV-Like Protein 1 / Q000502:physiology*; D005260:Female; D051858:Forkhead Transcription Factors / Q000096:biosynthesis* / Q000235:genetics; D005865:Gestational Age; D008297:Male; D051379:Mice; D019579:Neocortex / Q000196:embryology / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000096:biosynthesis* / Q000235:genetics; D055495:Neurogenesis / Q000235:genetics*; D010766:Phosphorylation; D014176:Protein Biosynthesis; D011499:Protein Processing, Post-Translational; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D012097:Repressor Proteins / Q000096:biosynthesis / Q000235:genetics
chemical_list: D020413:3' Untranslated Regions; D000067780:ELAV-Like Protein 1; C000593997:Elavl1 protein, mouse; D051858:Forkhead Transcription Factors; C432917:Foxp1 protein, mouse; C432918:Foxp2 protein, mouse; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D012097:Repressor Proteins