title: Association of markers of endothelial dysregulation Ang1 and Ang2 with acute kidney injury in critically ill patients.
abstract: The role of endothelial dysregulation with acute kidney injury (AKI) in critically ill patients is unclear.
  
  
  
  We retrospectively assessed the associations of AKI with biomarkers of endothelial function and inflammation among 948 subjects admitted to the intensive care unit (ICU) at Harborview Medical Center (Seattle, WA, USA). From plasma obtained within 24 h of enrollment, we measured angiopoietin (Ang)-1 and Ang-2 alongside biomarkers of inflammation, including interleukin (IL)-6, IL-17 and granulocyte colony-stimulating factor. We tested for associations between standardized concentrations of biomarkers and AKI, defined by serum creatinine, from ICU admission to up to 7 days later.
  
  
  
  All biomarkers of inflammation and endothelial dysfunction were associated with AKI. After adjustment for demographics, comorbidities, and IL-6 concentration, every standard deviation of Ang-1 concentration was associated with a 19 % lower risk of AKI (relative risk (RR) = 0.85, 95 % confidence interval (CI) 0.77-0.93, p < 0.001). Conversely, higher Ang-2 concentration was associated with higher risk of AKI (RR per standard deviation = 1.17, 95 % CI 1.13-1.22, p < 0.001).
  
  
  
  In critically ill patients, plasma concentration of the endothelial growth factors Ang-1 and Ang-2 are associated with AKI, independently of inflammation.
authors.affiliation: Kidney Research Institute, Division of Nephrology, Department of Medicine, University of Washington, 325 9th Ave, Box 359606, Seattle, WA, 98104, USA. cassyrc@uw.edu.
authors.forename: Cassianne
authors.initials: C
authors.lastname: Robinson-Cohen
authors.affiliation: Kidney Research Institute, Division of Nephrology, Department of Medicine, University of Washington, 325 9th Ave, Box 359606, Seattle, WA, 98104, USA.
authors.forename: Ronit
authors.initials: R
authors.lastname: Katz
authors.affiliation: Kidney Research Institute, Division of Nephrology, Department of Medicine, University of Washington, 325 9th Ave, Box 359606, Seattle, WA, 98104, USA.|Department of Biostatistics, University of Washington, Seattle, WA, USA.
authors.forename: Brenda L
authors.initials: BL
authors.lastname: Price
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, Seattle, WA, USA.
authors.forename: Susanna
authors.initials: S
authors.lastname: Harju-Baker
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, Seattle, WA, USA.
authors.forename: Carmen
authors.initials: C
authors.lastname: Mikacenic
authors.affiliation: Kidney Research Institute, Division of Nephrology, Department of Medicine, University of Washington, 325 9th Ave, Box 359606, Seattle, WA, 98104, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Himmelfarb
authors.affiliation: Center for Lung Biology, Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA, USA.
authors.forename: W Conrad
authors.initials: WC
authors.lastname: Liles
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, Seattle, WA, USA.
authors.forename: Mark M
authors.initials: MM
authors.lastname: Wurfel
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood / Q000503:physiopathology*; D000328:Adult; D000368:Aged; D042683:Angiopoietin-1 / Q000032:analysis* / Q000097:blood; D042702:Angiopoietin-2 / Q000032:analysis* / Q000097:blood; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D015331:Cohort Studies; D016638:Critical Illness / Q000401:mortality; D005260:Female; D006801:Humans; D007362:Intensive Care Units / Q000458:organization & administration / Q000706:statistics & numerical data; D015850:Interleukin-6 / Q000032:analysis / Q000097:blood; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014861:Washington
chemical_list: C467630:ANGPT1 protein, human; C586513:ANGPT2 protein, human; D042683:Angiopoietin-1; D042702:Angiopoietin-2; D015415:Biomarkers; C508600:IL6 protein, human; D015850:Interleukin-6
keywords: Acute kidney injury; Endothelial dysfunction; Endothelial dysregulation; Sepsis