title: Effect of Hepatitis C Virus Coinfection on the Content of CD4(+) and CD8(+) T Cell Subpopulations in HIV-Infected Patients Receiving Antiretroviral Therapy.
abstract: We studied the effect of hepatitis C virus coinfection on T cell subpopulations in HIV-infected patients receiving antiretroviral therapy. Coinfection with hepatitis C virus was followed by a decrease in the number of naive CD4(+) T cells and an increase in the count of central CD8(+) memory T cells in these patients. Hepatitis C virus had no effect on the number of CD4(+) memory T cells (main target for HIV). This can explain the absence of strong negative effect of hepatitis C virus on the course of HIV infection.
authors.affiliation: Perm State National Research University, Perm, Russia. bioqueen@mail.ru.|Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences, Ekaterinburg, Russia. bioqueen@mail.ru.
authors.forename: L B
authors.initials: LB
authors.lastname: Korolevskaya
authors.affiliation: Perm State National Research University, Perm, Russia.|Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences, Ekaterinburg, Russia.
authors.forename: K V
authors.initials: KV
authors.lastname: Shmagel
authors.affiliation: Perm State National Research University, Perm, Russia.|Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences, Ekaterinburg, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Saidakova
authors.affiliation: Perm State National Research University, Perm, Russia.|Perm Regional Center for Prevention of AIDS and Infectious Diseases, Perm, Russia.
authors.forename: N G
authors.initials: NG
authors.lastname: Shmagel
authors.affiliation: Perm State National Research University, Perm, Russia.|Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences, Ekaterinburg, Russia.
authors.forename: S V
authors.initials: SV
authors.lastname: Slobodchikova
authors.affiliation: Perm State National Research University, Perm, Russia.|Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences, Ekaterinburg, Russia.|Ural Federal University Named after the First President of Russia B. N. Yeltsin, Ekaterinburg, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Chereshnev
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000494:pharmacology / Q000627:therapeutic use*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology; D016022:Case-Control Studies; D060085:Coinfection / Q000188:drug therapy / Q000276:immunology / Q000821:virology; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology* / Q000821:virology; D019698:Hepatitis C, Chronic / Q000188:drug therapy / Q000276:immunology* / Q000821:virology; D006801:Humans; D007372:Interferons / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D013950:Thymus Gland / Q000276:immunology / Q000473:pathology
chemical_list: D019380:Anti-HIV Agents; D007372:Interferons
keywords: HCV coinfection; HIV infection; T cell subpopulations; antiretroviral therapy