title: Detection superiority of 7 T MRI protocol in patients with epilepsy and suspected focal cortical dysplasia.
abstract: In 11 adult patients with suspicion of Focal cortical dysplasia (FCD) on 1.5 T (n = 1) or 3 T (n = 10) magnetic resonance imaging (MRI), 7 T MRI was performed. Visibility, extent, morphological features and delineation were independently rated and subsequently discussed by three observers. Additionally, head-to-head comparisons with corresponding 3 T images were made in the eight patients with a previous 3 T MRI and sustained suspicion of FCD. Comparison with histopathology was done in the five patients that underwent surgery. All lesions, seen at 1.5 and 3 T, were also recognized on 7 T. At 7 T FLAIR highlighted the FCD-like lesions best, whereas T2 and T2* were deemed better suited to review structure and extent of the lesion. Image quality with the used 7 T MRI setup was higher than the quality with the used 3 T MRI setup. In 2 out of 11 patients diagnosis changed, in one after re-evaluation of the images, and in the other based on histopathology. With the used 7 T MRI setup, FCD-like lesions can be detected with more confidence and detail as compared to lower field strength. However, concordance between radiologic diagnosis and final diagnosis seems to be lower than expected.
authors.affiliation: Academic Center for Epileptology Kempenhaeghe, Maastricht Universitair Medisch Centrum + (MUMC+), Sterkselseweg 65, 5590 VE, Heeze, The Netherlands. colona@kempenhaeghe.nl.|Department of Radiology, Leiden University Medical Centre, Leiden, The Netherlands. colona@kempenhaeghe.nl.|Department of Neurology, University Hospital Gent, Ghent, Belgium. colona@kempenhaeghe.nl.
authors.forename: A J
authors.initials: AJ
authors.lastname: Colon
authors.affiliation: Department of Radiology, Leiden University Medical Centre, Leiden, The Netherlands.
authors.forename: M J P
authors.initials: MJ
authors.lastname: van Osch
authors.affiliation: Department of Radiology, Leiden University Medical Centre, Leiden, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Buijs
authors.affiliation: Department of Radiology, Leiden University Medical Centre, Leiden, The Netherlands.
authors.forename: J V D
authors.initials: JV
authors.lastname: Grond
authors.affiliation: Academic Center for Epileptology Kempenhaeghe, Maastricht Universitair Medisch Centrum + (MUMC+), Sterkselseweg 65, 5590 VE, Heeze, The Netherlands.|Department of Neurology, University Hospital Gent, Ghent, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Boon
authors.affiliation: Department of Radiology, Leiden University Medical Centre, Leiden, The Netherlands.
authors.forename: M A
authors.initials: MA
authors.lastname: van Buchem
authors.affiliation: Academic Center for Epileptology Kempenhaeghe, Maastricht Universitair Medisch Centrum + (MUMC+), Sterkselseweg 65, 5590 VE, Heeze, The Netherlands.
authors.forename: P A M
authors.initials: PA
authors.lastname: Hofman
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology*; D003937:Diagnosis, Differential; D003951:Diagnostic Errors / Q000517:prevention & control; D004827:Epilepsy / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D054220:Malformations of Cortical Development / Q000175:diagnosis*; D008875:Middle Aged; D055815:Young Adult
keywords: 7 T MRI; Epilepsy; Focal cortical dysplasia; Human; Misdiagnosis