title: MCR-1 in multidrug-resistant and copper-tolerant clinically relevant Salmonella 1,4,[5],12:i:- and S. Rissen clones in Portugal, 2011 to 2015.
abstract: The mcr-1 gene was found in 11 isolates from a Portuguese Salmonella collection (n = 1,010; 58 serotypes; 2002-15) of clinical samples, foodstuff, food-animals and water. Mcr-1 has been located on different plasmids (IncX4/IncHI2) in pig-associated multidrug-resistant, copper-tolerant S.1,4,[5],12:i:-/ST34 and S. Rissen/ST469 clones from human and pork products since at least 2011. Our data highlight dissemination of mcr-1 by successful resistant clones in Europe and raise questions about the efficacy of copper-based interventions to reduce colistin use.
authors.affiliation: UCIBIO/REQUIMTE, Department of Biological Sciences, Microbiology laboratory, Pharmacy Faculty, University of Porto, Porto, Portugal.
authors.forename: Joana
authors.initials: J
authors.lastname: Campos
authors.forename: Luís
authors.initials: L
authors.lastname: Cristino
authors.forename: Luísa
authors.initials: L
authors.lastname: Peixe
authors.forename: Patrícia
authors.initials: P
authors.lastname: Antunes
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D002999:Clone Cells / Q000187:drug effects; D003300:Copper / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D024881:Drug Resistance, Bacterial / Q000502:physiology*; D018432:Drug Resistance, Multiple / Q000187:drug effects / Q000502:physiology; D029968:Escherichia coli Proteins / Q000235:genetics* / Q000378:metabolism*; D005516:Food Microbiology; D006801:Humans; D012475:Salmonella / Q000145:classification / Q000187:drug effects* / Q000502:physiology*; D013552:Swine
chemical_list: D000900:Anti-Bacterial Agents; D029968:Escherichia coli Proteins; C000614037:MCR-1 protein, E coli; D003300:Copper
keywords: S. 1,4,[5],12:i:-; S. Rissen, clones; Salmonella; colistin resistance; copper tolerance; mcr-1