title: Dynamic Contrast-enhanced MR Imaging in Renal Cell Carcinoma: Reproducibility of Histogram Analysis on Pharmacokinetic Parameters.
abstract: Pharmacokinetic parameters derived from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) have been increasingly used to evaluate the permeability of tumor vessel. Histogram metrics are a recognized promising method of quantitative MR imaging that has been recently introduced in analysis of DCE-MRI pharmacokinetic parameters in oncology due to tumor heterogeneity. In this study, 21 patients with renal cell carcinoma (RCC) underwent paired DCE-MRI studies on a 3.0 T MR system. Extended Tofts model and population-based arterial input function were used to calculate kinetic parameters of RCC tumors. Mean value and histogram metrics (Mode, Skewness and Kurtosis) of each pharmacokinetic parameter were generated automatically using ImageJ software. Intra- and inter-observer reproducibility and scan-rescan reproducibility were evaluated using intra-class correlation coefficients (ICCs) and coefficient of variation (CoV). Our results demonstrated that the histogram method (Mode, Skewness and Kurtosis) was not superior to the conventional Mean value method in reproducibility evaluation on DCE-MRI pharmacokinetic parameters (K( trans) &Ve) in renal cell carcinoma, especially for Skewness and Kurtosis which showed lower intra-, inter-observer and scan-rescan reproducibility than Mean value. Our findings suggest that additional studies are necessary before wide incorporation of histogram metrics in quantitative analysis of DCE-MRI pharmacokinetic parameters.
authors.affiliation: Department of Radiology, Chinese PLA General Hospital, Beijing, 100853, China.
authors.forename: Hai-Yi
authors.initials: HY
authors.lastname: Wang
authors.affiliation: Lift Science, Advanced Application Team, GE Healthcare China, Beijing, 100176, China.
authors.forename: Zi-Hua
authors.initials: ZH
authors.lastname: Su
authors.affiliation: Lift Science, Advanced Application Team, GE Healthcare China, Shanghai, 201203, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Radiology, No.1 Hospital of Zhangjiakou, Hebei, 075000, China.
authors.forename: Zhi-Peng
authors.initials: ZP
authors.lastname: Sun
authors.affiliation: Medical Imaging Center, Jiayuguan Jiugang Hospital, Jiayuguan, Gansu, 735100, China.
authors.forename: Fei-Xue
authors.initials: FX
authors.lastname: Duan
authors.affiliation: Department of Radiology, General Hospital of Pingdingshan Coal Group, Pingdingshan, Henan, 467000, China.
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Song
authors.affiliation: Department of Radiology, Chinese PLA General Hospital, Beijing, 100853, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Radiology, Chinese PLA General Hospital, Beijing, 100853, China.
authors.forename: Ying-Wei
authors.initials: YW
authors.lastname: Wang
authors.affiliation: Department of Urology, Chinese PLA General Hospital, Beijing, 100853, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Pathology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Ai-Tao
authors.initials: AT
authors.lastname: Guo
authors.affiliation: Department of Radiology, Chinese PLA General Hospital, Beijing, 100853, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Ma
authors.affiliation: Department of Radiology, Chinese PLA General Hospital, Beijing, 100853, China.
authors.forename: Hui-Yi
authors.initials: HY
authors.lastname: Ye
mesh_terms: D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000000981:diagnostic imaging*; D003287:Contrast Media / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results
chemical_list: D003287:Contrast Media