title: Serum albumin level is associated with the recurrence of acute ischemic stroke.
abstract: BACKGROUND
  Previous studies have confirmed that low serum albumin levels in acute ischemic stroke patients increased the risk for poor outcome and death, demonstrating the neuroprotective role of albumin. However, there are few studies investigating the relationship between albumin levels and recurrence of stroke. The aim of this study was to evaluate the effect of serum albumin level on the risk of recurrence in patients with acute ischemic stroke.
  
  
  METHODS
  Seven hundred fifty-three consecutive patients with acute first-ever ischemic stroke were recruited in this study. Recurrent outcome was measured 1 year after stroke through home interviews (n = 692).
  
  
  RESULTS
  Patients with recurrence had significantly lower serum albumin level than those without recurrence (37.07 ± 4.21 vs 38.91 ± 3.25). The multiple logistic regression adjustment for confounding factors showed that the association remained significant for patients in the second albumin quartile, the third quartile, and the fourth quartile compared with patients in the first quartile (adjusted odds ratio [aOR] = 0.543, 95% confidence interval [CI]: 0.307-0.959, P= .036; aOR = 0.449, 95% CI: 0.249-0.812, P= .008; and aOR = 0.290, 95% CI: 0.148-0.570, P < .001).
  
  
  CONCLUSIONS
  Lower serum albumin level increases the risk of recurrence in patients with acute ischemic stroke, suggesting that serum albumin level might be used as an indicator for stroke recurrence.
authors.affiliation: Institute of Public Health, School of Nursing, Henan University, Kaifeng, 475004, China. Electronic address: zq71200@163.com.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Preventive Medicine, School of Public Health, Guangzhou Medical University, Guangzhou, 510180, China. Electronic address: gz-leizeng@163.com.
authors.forename: Yi-Xiong
authors.initials: YX
authors.lastname: Lei
authors.affiliation: Institute of Public Health, School of Nursing, Henan University, Kaifeng, 475004, China. Electronic address: kfwq@henu.edu.cn.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Institute of Public Health, School of Nursing, Henan University, Kaifeng, 475004, China. Electronic address: jinyongping@henu.edu.cn.
authors.forename: Yong-Ping
authors.initials: YP
authors.lastname: Jin
authors.affiliation: Internal Medicine-Neurology, Huaihe Hospital, Henan University, Kaifeng, 475000, China. Electronic address: 15225475536@163.com.
authors.forename: Rong-Li
authors.initials: RL
authors.lastname: Fu
authors.affiliation: Institute of Public Health, School of Nursing, Henan University, Kaifeng, 475004, China. Electronic address: 15226003150@163.com.
authors.forename: He-Hong
authors.initials: HH
authors.lastname: Geng
authors.affiliation: Institute of Public Health, School of Nursing, Henan University, Kaifeng, 475004, China. Electronic address: huanglingling0703@163.com.
authors.forename: Ling-Ling
authors.initials: LL
authors.lastname: Huang
authors.affiliation: Institute of Public Health, School of Nursing, Henan University, Kaifeng, 475004, China. Electronic address: xiaoxiao52625@163.com.
authors.forename: Xiao-Xiao
authors.initials: XX
authors.lastname: Wang
authors.affiliation: Institute of Public Health, School of Nursing, Henan University, Kaifeng, 475004, China; Department of Preventive Medicine, School of Public Health, Guangzhou Medical University, Guangzhou, 510180, China. Electronic address: peixi001@163.com.
authors.forename: Pei-Xi
authors.initials: PX
authors.lastname: Wang
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000150:complications / Q000453:epidemiology / Q000378:metabolism*; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D034141:Hypoalbuminemia / Q000453:epidemiology / Q000378:metabolism*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000453:epidemiology / Q000378:metabolism*; D016017:Odds Ratio; D050177:Overweight / Q000453:epidemiology / Q000378:metabolism*; D011379:Prognosis; D011446:Prospective Studies; D012008:Recurrence; D012307:Risk Factors; D012709:Serum Albumin / Q000378:metabolism*; D020521:Stroke / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism*; D013851:Thinness / Q000453:epidemiology / Q000378:metabolism*
chemical_list: D012709:Serum Albumin