title: Cardioprotection by 6-gingerol in diabetic rats.
abstract: The current study was conducted to evaluate the effect of 6-gingerol (6G) on cardiac complications in streptozotocin (STZ)-induced diabetic (DM) rats. STZ-induced DM rats (single 50 mg/kg i.p. injection, 15 days prior to drug treatment) or time-matched controls were treated with 6G (75 mg/day route orally). After a further 8 weeks, blood was collected for biochemical analysis and 8-isoprostenol was measured in urine. Cardiac hemodynamics and ECG was assessed. 6G significantly attenuated the increased level of blood glucose in diabetic rats and improved cardiac hemodynamics in including RR interval, max dP/dt, min dP/dt and Tau. In addition, 6G alleviated the elevated ST segment, T amplitude and R amplitude with no significant effect on disturbed levels of adiponectin, TGF-β or 8-isoprostenol induced by diabetes. The results showed that treatment with 6G has an ameliorative effect on cardiac dysfunction induced by diabetes. Which may be not related to its potential antioxidant effect.
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Pharmacology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
authors.forename: Hany M
authors.initials: HM
authors.lastname: El-Bassossy
authors.affiliation: Department of Clinical Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Pharmacology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt. Electronic address: berry_ahmed@yahoo.com.
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Elberry
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Salah A
authors.initials: SA
authors.lastname: Ghareib
authors.affiliation: Department of Pediatric Cardiology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Azhar
authors.affiliation: Department of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Zainy Mohammed
authors.initials: ZM
authors.lastname: Banjar
authors.affiliation: Department of Pharmacy and Pharmacology, University of Bath, Bath, UK.
authors.forename: Malcolm L
authors.initials: ML
authors.lastname: Watson
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000008:administration & dosage*; D002396:Catechols / Q000008:administration & dosage*; D003921:Diabetes Mellitus, Experimental / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology*; D058065:Diabetic Cardiomyopathies / Q000175:diagnosis / Q000503:physiopathology* / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D005233:Fatty Alcohols / Q000008:administration & dosage*; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D016896:Treatment Outcome
chemical_list: D002316:Cardiotonic Agents; D002396:Catechols; D005233:Fatty Alcohols; D007004:Hypoglycemic Agents; C007845:gingerol
keywords: 6-Gingerol; Adiponectin; Cardioprotection; Diabetes; Electrocardiogram; Hemodynamics; Vascular complications