title: Evaluation of antiviral activity of plant extracts against foot and mouth disease virus in vitro.
abstract: The aim of this study was to evaluate antiviral activity of chloroformic leaves extracts of three plants: Azadirachta indica, Moringa oleifera and Morus alba against Foot and Mouth disease virus using MTT assay (3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide). Antiviral and cytotoxic activity of each extract was evaluated as cell survival percentage and results were expressed as Means ± S.D. The concentrations which resulted in cell survival percentages of greater than 50% are considered to be effective antiviral concentrations. From the tested plant extracts, Moringa oleifera showed potent antiviral activity (p<0.05) while Azadirachta indica showed significant antiviral activity in the range of 1-50μ/ml & 12-100μ/ml respectively. In contrast no antiviral activity was observed by Morus alba as all the tested concentration resulted in significant reduction (p<0.05) in cell survival percentage.
authors.affiliation: Faculty of Pharmacy, Hamdard University, Karachi.
authors.forename: Ishrat
authors.initials: I
authors.lastname: Younus
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi.
authors.forename: Afshan
authors.initials: A
authors.lastname: Siddiq
authors.affiliation: Faculty of Pharmacy, Hamdard University, Karachi.
authors.forename: Humera
authors.initials: H
authors.lastname: Ishaq
authors.affiliation: Faculty of Pharmacy, Hamdard University, Karachi.
authors.forename: Laila
authors.initials: L
authors.lastname: Anwer
authors.affiliation: Faculty of Pharmacy, Hamdard University, Karachi.
authors.forename: Sehrish
authors.initials: S
authors.lastname: Badar
authors.affiliation: Department of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ashraf
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D031601:Azadirachta; D029544:Foot-and-Mouth Disease Virus / Q000187:drug effects*; D029588:Moringa oleifera; D031625:Morus; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D010936:Plant Extracts