title: Leishmaniasis with Femoral Bone Involvement.
abstract: Visceral leishmaniasis is mostly subclinical, but it can become symptomatic and take acute, subacute or chronic forms. Its incubation period varies from weeks to months and can even be as long as years. Avast variety of organ involvement may be there. We report a case of osseous leishmaniasis presenting with only a long standing mild knee pain without any laboratory or organ abnormality and showed a pure bone involvement on X-ray and CTscan. Later on, it developed into a discharging sinus and the discharge showed Leishman bodies which was reconfirmed the rough bite. As the patient had reactions with amphotericin B, systemic glucantine was given which led to clinical improvement and smaller radiological lesion.
authors.affiliation: Department of Orthopedics, Islamic Azad University, Medical Branch, Mashhad, Iran.
authors.forename: Payman
authors.initials: P
authors.lastname: Sasannejad
authors.affiliation: Laboratory Expert, Mashhad, Iran.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Mazloum Farsi Baf
authors.affiliation: Department of Dermatology, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Naghmeh
authors.initials: N
authors.lastname: Zabolinejad
authors.affiliation: Islamic Azad University, Medical Branch, Mashhad, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Behdani
authors.affiliation: Islamic Azad University, Medical Branch, Mashhad, Iran.
authors.forename: Morteza
authors.initials: M
authors.lastname: Mazloum Farsi Baf
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000913:Antibodies, Protozoan / Q000097:blood; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D001853:Bone Marrow / Q000382:microbiology / Q000473:pathology*; D005269:Femur; D006801:Humans; D007717:Knee / Q000000981:diagnostic imaging; D007891:Leishmania / Q000302:isolation & purification*; D007898:Leishmaniasis, Visceral / Q000175:diagnosis* / Q000188:drug therapy; D008536:Meglumine / Q000627:therapeutic use; D000077485:Meglumine Antimoniate; D009942:Organometallic Compounds / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000913:Antibodies, Protozoan; D000981:Antiprotozoal Agents; D009942:Organometallic Compounds; D008536:Meglumine; D000077485:Meglumine Antimoniate; D000666:Amphotericin B