title: Long-Term Endoscopic Follow-Up of Patients with Chronic Radiation Proctopathy after Brachytherapy for Prostate Cancer.
abstract: Background. Chronic radiation proctopathy (CRP) is late toxicity and associated with morbidity. Aim. To investigate the predictors of prognosis in patients with CRP after brachytherapy (BT). Methods. One hundred four patients with prostate cancer were treated with BT or BT followed by external-beam radiotherapy (BT + EBRT). We retrospectively investigated the 5-year incidence of rectal bleeding and endoscopic findings of CRP using the Vienna Rectoscopy Score (VRS). Twenty patients with VRS ≥ 1 were divided into the improved VRS group without treatment, unchanged VRS group, and treated group. The parameters associated with alteration of VRS were analyzed. Results. The incidence of rectal bleeding was 24%. The risk of rectal bleeding was higher in patients treated with BT + EBRT compared to those treated with BT (p < 0.0001). The incidence of superficial microulceration was higher in the improved VRS group than in the unchanged VRS group (p < 0.05). The incidence of multiple confluent telangiectasia or superficial ulcers > 1 cm(2) was higher in the treated group than in both the improved and unchanged VRS groups (p < 0.05). Conclusions. Patients treated with BT + EBRT have a high risk of CRP. Endoscopic findings were useful for prognostic prediction of CRP.
authors.affiliation: Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ohtani
authors.affiliation: Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Suto
authors.affiliation: Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan.
authors.forename: Takuto
authors.initials: T
authors.lastname: Nosaka
authors.affiliation: Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Saito
authors.affiliation: Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan.
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Ozaki
authors.affiliation: Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan.
authors.forename: Ryoko
authors.initials: R
authors.lastname: Hayama
authors.affiliation: Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan.
authors.forename: Tatsushi
authors.initials: T
authors.lastname: Naito
authors.affiliation: Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan.
authors.forename: Kazuto
authors.initials: K
authors.lastname: Takahashi
authors.affiliation: Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan.
authors.forename: Kazuya
authors.initials: K
authors.lastname: Ofuji
authors.affiliation: Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan.
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Matsuda
authors.affiliation: Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan.
authors.forename: Katsushi
authors.initials: K
authors.lastname: Hiramatsu
authors.affiliation: Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Nemoto
authors.affiliation: Department of Radiology, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Shioura
authors.affiliation: Department of Radiology, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan.
authors.forename: Hirohiko
authors.initials: H
authors.lastname: Kimura
authors.affiliation: Department of Urology, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan.
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Aoki
authors.affiliation: Department of Urology, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Yokoyama
authors.affiliation: Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan.
authors.forename: Yasunari
authors.initials: Y
authors.lastname: Nakamoto