title: Hierarchical mesoporous silica nanoparticles for tailorable drug release.
abstract: In order to modulate the drug release profiles, the hierarchical mesoporous silica nanoparticles (HMSNs) are fabricated by a two-step synthetic process. The HMSNs exhibit uniform spherical morphology with nanoscaled size, well mono-dispersed size distribution, and smooth surface. Because of the hierarchical pore structures with different mesoporous sizes and morphologies (partial open and partial blocked pores), the HMSNs can release the loaded drug in a controlled manner. The hierarchical mesoporous structures directed drug release profiles suggest a feasible strategy to tailor drug release behaviors. Meanwhile, the HMSNs exhibit good biocompatibility. Therefore, the HMSNs having tailorable drug release capacity would be a potential candidate to improve their therapeutic efficiency for drug delivery systems.
authors.affiliation: College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China; Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory For Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400044, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.affiliation: Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200433, China.
authors.forename: Chenyu
authors.initials: C
authors.lastname: Ye
authors.affiliation: Department of Pain Management, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Xiao
authors.affiliation: College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China.
authors.forename: Xiaowen
authors.initials: X
authors.lastname: Sun
authors.affiliation: College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China.
authors.forename: Wenhao
authors.initials: W
authors.lastname: Qu
authors.affiliation: Changzhou Institute of Engineering Technology, Changzhou 213164, China.
authors.forename: Xiuhua
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200433, China. Electronic address: chenmin@fudan.edu.cn.
authors.forename: Min
authors.initials: M
authors.lastname: Chen
authors.affiliation: College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China; State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China. Electronic address: jianshu_li@scu.edu.cn.
authors.forename: Jianshu
authors.initials: J
authors.lastname: Li
mesh_terms: D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D065546:Drug Liberation; D006367:HeLa Cells; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism*; D016062:Porosity; D012822:Silicon Dioxide / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*
chemical_list: D012822:Silicon Dioxide
keywords: Biocompatibility; Biomedical applications; Hierarchical meso-porosity; Mesoporous silica nanoparticles (MSNs); Tailorable drug release