title: Surgery Combined with Radiotherapy to Treat Spinal Tumors: A Review of Published Reports.
abstract: Spinal tumors result in high morbidity and a high rate of lower limb paralysis. Both surgical therapy and radiation therapy (RT) are used to treat spinal tumors; however, how best to combine these two therapies to maximize the benefits and minimize the risks is still being debated. It is also difficult to decide the optimal timing, course and dose of RT, especially in pregnant women and children. The aim of this review is to assist surgeons who are dealing with spinal tumors by providing comprehensive information about advanced techniques for administering RT with greater precision and safety, and about the impact of various ways of combining surgery and RT on therapeutic outcomes. We here review published reports about treating spinal tumors with a combination of these two forms of therapy and attempt to draw appropriate conclusions concerning selection of optimal treatment protocols. Our conclusion is that postoperative radiotherapy, especially with high-precision, low-dose and multiple fractions, and brachytherapy are promising therapies to combined with surgery.
authors.affiliation: Department of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: Chong
authors.initials: C
authors.lastname: Bian
authors.affiliation: Department of Orthopaedic Surgery, Zhongshan Hospital Qingpu Branch, Fudan University, Shanghai, China.
authors.forename: Nong
authors.initials: N
authors.lastname: Chen
authors.affiliation: Department of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: Xi-Lei
authors.initials: XL
authors.lastname: Li
authors.affiliation: Department of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: Xiao-Gang
authors.initials: XG
authors.lastname: Zhou
authors.affiliation: Department of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Lin
authors.affiliation: Department of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: Li-Bo
authors.initials: LB
authors.lastname: Jiang
authors.affiliation: Department of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: Wang-Mi
authors.initials: WM
authors.lastname: Liu
authors.affiliation: Department of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Department of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Dong
mesh_terms: D003131:Combined Modality Therapy; D006801:Humans; D013125:Spinal Neoplasms / Q000532:radiotherapy* / Q000601:surgery*
keywords: Radiation therapy; Spinal tumor; Surgery; Therapeutic effect; Treatment protocol selection