title: Homeostasis Model Assessment-Adiponectin: the role of different types of physical exercise in obese adolescents.
abstract: BACKGROUND
  Homeostasis Model Assessment-Adiponectin (HOMA-AD) is suggesting a new biomarker of insulin resistance in obese population. In this way, the purpose of this study was to investigate the effects of different kinds of exercise in the sensitive index predictor of insulin resistance.
  
  
  METHODS
  A total of 148 obese adolescents were enrolled in the program. They aged 15-19 y, with Body Mass Index (BMI) ≥P95th and were submitted to 1 year of interdisciplinary weight loss therapy, randomized in two groups, aerobic training (AT) (N.=51) and aerobic plus resistance training (N.=97). Blood samples were collected to analyze adiponectin, glucose and insulin concentrations. The insulin resistance was measured by HOMA-AD and Homeostasis Model Assessment Insulin Resistance Index (HOMA-IR).
  
  
  RESULTS
  Both kinds of exercise training promoted a decrease in body mass, body mass index, fat mass, visceral and subcutaneous fat. However, only aerobic plus resistance training was effective to reduce HOMA-AD, insulin and glucose concentration; and increase insulin sensibility and adiponectin concentration.
  
  
  CONCLUSIONS
  The aerobic plus resistance training was more effective than AT alone to improve the HOMA-AD, suggesting clinical application on obesity, diabetes, atherosclerosis and metabolic syndrome control in the pediatric population.
authors.affiliation: Department of Physiotherapy, Therapeutic Resources Laboratory, Federal University of São Carlos, (UFSCar), São Carlos, Brazil - raquelmunhoz@hotmail.com.|Post Graduate Program of Nutrition, Federal University of São Paulo (UNIFESP), São Paulo, Brazil - raquelmunhoz@hotmail.com.
authors.forename: Raquel M
authors.initials: RM
authors.lastname: da Silveira Campos
authors.affiliation: Post Graduate Program of Nutrition, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
authors.forename: Deborah C
authors.initials: DC
authors.lastname: Landi Masquio
authors.affiliation: Post Graduate Program of Nutrition, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
authors.forename: Flávia
authors.initials: F
authors.lastname: Campos Corgosinho
authors.affiliation: Post Graduate Program of Nutrition, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
authors.forename: Priscila
authors.initials: P
authors.lastname: de Lima Sanches
authors.affiliation: University Center São Camilo (CUSC), São Paulo, Brazil.
authors.forename: Aline
authors.initials: A
authors.lastname: de Piano
authors.affiliation: Post Graduate Program of Nutrition, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
authors.forename: June
authors.initials: J
authors.lastname: Carnier
authors.affiliation: Federal University of Goiás (UFG), Jataí, Brazil.
authors.forename: Patrícia
authors.initials: P
authors.lastname: Leão da Silva
authors.affiliation: Federal University of Alagoas, Maceió, Brazil.
authors.forename: Ana P
authors.initials: AP
authors.lastname: Grotti Clemente
authors.affiliation: Post Graduate Program of Nutrition, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
authors.forename: Sofia E
authors.initials: SE
authors.lastname: de Castro Ferreira Vicente
authors.affiliation: Post Graduate Program of Nutrition, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
authors.forename: Lila M
authors.initials: LM
authors.lastname: Oyama
authors.affiliation: Post Graduate Program of Nutrition, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
authors.forename: Claudia M
authors.initials: CM
authors.lastname: da Penha Oller do Nascimento
authors.affiliation: Weight Science, São Paulo, Brazil.
authors.forename: Lian
authors.initials: L
authors.lastname: Tock
authors.affiliation: Department of Psychobiology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
authors.forename: Sergio
authors.initials: S
authors.lastname: Tufik
authors.affiliation: Post Graduate Program of Nutrition, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.|Department of Psychobiology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.|School of Physical Education, Physiotherapy and Occupational Therapy, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
authors.forename: Marco T
authors.initials: MT
authors.lastname: de Mello
authors.affiliation: Post Graduate Program of Nutrition, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
authors.forename: Ana R
authors.initials: AR
authors.lastname: Dâmaso
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D015992:Body Mass Index; D015444:Exercise / Q000502:physiology*; D005081:Exercise Therapy / Q000379:methods; D005260:Female; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D024821:Metabolic Syndrome / Q000628:therapy; D063766:Pediatric Obesity / Q000097:blood* / Q000628:therapy; D055070:Resistance Training
chemical_list: D052242:Adiponectin; D007328:Insulin