title: Prognostic Impact of the Signet Ring Cell Type in Node-Negative Gastric Cancer.
abstract: Little is known regarding the prognostic impact of the signet ring cell (SRC) histotype on negative lymph nodes (LNs) in gastric cancer (GC). In this study, we aimed to investigate the differences between SRC and non-SRC GC patients without LN metastasis. The medical records of patients with GC who underwent gastrectomy at Sun Yat-Sen University Cancer Centre from 1996 to 2012 were reviewed to analyse the clinicopathologic characteristics associated with survival. A total of 480 cases of GC patients without LN metastasis were identified, which included 90 SRC GC patients and 390 non-SRC GC patients. Between the two groups, there were a host of significant differences in the American Joint Committee on Cancer, 7th edition (AJCC) stage. We found that SRC histology was correlated with a poor prognosis in terms of recurrence in node-negative GC patients and that SRC histologic analysis combined with AJCC staging maybe an effectual method for prediction of the recurrence rate. Additionally, we found that SRC GC presents a more dismal overall prognosis in patients with perineural or vascular invasion.
authors.affiliation: State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine, Guangzhou, China.|Department of the VIP region, Sun Yat-sen University Cancer Centre, Guangzhou, China.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Kong
authors.affiliation: State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine, Guangzhou, China.
authors.forename: Ruiyan
authors.initials: R
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine, Guangzhou, China.|Department of the Gynaecologic Oncology Surgery, Sun Yat-sen University Cancer Centre, Guangzhou, China.
authors.forename: Chenlu
authors.initials: C
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine, Guangzhou, China.|Department of Hematology Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China.
authors.forename: Qirong
authors.initials: Q
authors.lastname: Geng
authors.affiliation: State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine, Guangzhou, China.|Department of Gastric and Pancreatic Surgery, Sun Yat-sen University Cancer Centre, Guangzhou, China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine, Guangzhou, China.|Department of Gastric and Pancreatic Surgery, Sun Yat-sen University Cancer Centre, Guangzhou, China.
authors.forename: Shangxiang
authors.initials: S
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine, Guangzhou, China.|Department of Gastric and Pancreatic Surgery, Sun Yat-sen University Cancer Centre, Guangzhou, China.
authors.forename: Xuechao
authors.initials: X
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine, Guangzhou, China.|Department of the VIP region, Sun Yat-sen University Cancer Centre, Guangzhou, China.
authors.forename: Minting
authors.initials: M
authors.lastname: Ye
authors.affiliation: State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine, Guangzhou, China.|Department of the VIP region, Sun Yat-sen University Cancer Centre, Guangzhou, China.
authors.forename: Wenzhuo
authors.initials: W
authors.lastname: He
authors.affiliation: State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine, Guangzhou, China.|Department of the VIP region, Sun Yat-sen University Cancer Centre, Guangzhou, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine, Guangzhou, China.|Department of the VIP region, Sun Yat-sen University Cancer Centre, Guangzhou, China.
authors.forename: Liangping
authors.initials: L
authors.lastname: Xia
authors.affiliation: State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine, Guangzhou, China.|Department of Gastric and Pancreatic Surgery, Sun Yat-sen University Cancer Centre, Guangzhou, China.
authors.forename: Dazhi
authors.initials: D
authors.lastname: Xu
mesh_terms: D000368:Aged; D018279:Carcinoma, Signet Ring Cell / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D002681:China / Q000453:epidemiology; D005260:Female; D005743:Gastrectomy; D006801:Humans; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D011379:Prognosis; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery