title: [Grading of soft tissue and bone sarcomas].
abstract: Malignancy grading is an essential element in the classification of sarcomas. It correlates with the prognosis of the disease and the risk of metastasis. This article presents the grading schemes for soft tissue, bone and pediatric sarcomas. It summarizes the histological criteria of the Federation Nationale des Centres de Lutte Contre le Cancer (FNCLCC) system and the Pediatric Oncology Group as well as the grading of bone tumors by the College of American Pathologists (CAP). Furthermore, the potential relevance of gene expression signatures, the complexity index in sarcoma (CINSARC) and single genetic alterations (p53, MDM2, p16, SWI/SNF, EWSR1 fusions and PAX3/PAX7-FOXO1 fusions) for the prognosis of sarcomas are discussed.
authors.affiliation: Institut für Pathologie, Universitätsklinikum Jena, Ziegelmühlenweg 1, 07743, Jena, Deutschland. iver.petersen@med.uni-jena.de.
authors.forename: I
authors.initials: I
authors.lastname: Petersen
authors.affiliation: Gerhard-Domagk-Institut für Pathologie, Universitätsklinikum Münster, Münster, Deutschland.
authors.forename: E
authors.initials: E
authors.lastname: Wardelmann
mesh_terms: D000328:Adult; D001706:Biopsy; D001859:Bone Neoplasms / Q000145:classification / Q000235:genetics / Q000473:pathology*; D001842:Bone and Bones / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D002648:Child; D003238:Connective Tissue / Q000473:pathology; D030342:Genetic Diseases, Inborn / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D060787:Neoplasm Grading; D009362:Neoplasm Metastasis; D011379:Prognosis; D012306:Risk; D012509:Sarcoma / Q000145:classification / Q000235:genetics / Q000473:pathology*; D012983:Soft Tissue Neoplasms / Q000145:classification / Q000235:genetics / Q000473:pathology*; D059467:Transcriptome / Q000235:genetics
chemical_list: D005819:Genetic Markers
keywords: Classification; Metastasis; Mutation; Prognosis; Sarcoma