title: ARPP-19 promotes proliferation and metastasis of human glioma.
abstract: Glioma is the most common and aggressive type of human primary brain tumor with a poor outcome. The molecular mechanisms underlying glioma development and progression are still poorly understood. Recent studies have reported a novel role of ARPP-19 in the regulation of cell mitosis and cancer progression. However, no study has been carried out to determine the role of ARPP-19 in human glioma cells and assess the expression and clinical significance of ARPP-19 in human glioma. In this study, we systematically examined the role of ARPP-19 in glioma A172 cells and examined the expression of ARPP-19 and CD147 in 81 cases of human glioma tissue specimens and correlated them to clinicopathological parameters and patient survival. We found that ARPP-19 promoted both proliferation and metastasis of human glioma cells and the expression of ARPP-19 and CD147 in high-grade glioma was significantly higher than that in the low-grade glioma. Patients whose tumors were positive for expression of ARPP-19 or CD147 showed lower relapse-free survival and overall survival than patients whose tumors were negative for ARPP-19 or CD147, respectively. Pearson correlation analysis indicated that there was a statistically significant correlation between ARPP-19 and CD147. Expressions of ARPP-19 and CD147 may serve as biomarkers for high-grade glioma and poor patient survival.
authors.affiliation: Departments of aNeurosurgery bPathology, the Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui cDepartment of Neurosurgery, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
authors.forename: Bing
authors.initials: B
authors.lastname: Zhao
authors.forename: Xiaocan
authors.initials: X
authors.lastname: Li
authors.forename: Jinghai
authors.initials: J
authors.lastname: Wan
mesh_terms: D051926:Basigin / Q000378:metabolism; D001932:Brain Neoplasms / Q000378:metabolism* / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D005910:Glioma / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D060787:Neoplasm Grading; D009362:Neoplasm Metastasis; D010750:Phosphoproteins / Q000378:metabolism*
chemical_list: C497886:BSG protein, human; D010750:Phosphoproteins; C064321:cyclic AMP-regulated phosphoprotein 19; D051926:Basigin