title: Transcriptional Engineering of Microalgae: Prospects for High-Value Chemicals.
abstract: Microalgae are diverse microorganisms that are of interest as novel sources of metabolites for various industrial, nutritional, and pharmaceutical applications. Recent studies have demonstrated transcriptional engineering of some metabolic pathways. We propose here that transcriptional engineering could be a viable means to manipulate the biosynthesis of specific high-value metabolic products.
authors.affiliation: Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK; Department of Plant Physiology, Umeå Plant Science Center, Umeå University, 90187 Umeå, Sweden.
authors.forename: Amit K
authors.initials: AK
authors.lastname: Bajhaiya
authors.affiliation: Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK.
authors.forename: Javiera
authors.initials: J
authors.lastname: Ziehe Moreira
authors.affiliation: Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK. Electronic address: jon.pittman@manchester.ac.uk.
authors.forename: Jon K
authors.initials: JK
authors.lastname: Pittman
mesh_terms: D020418:Algal Proteins / Q000235:genetics* / Q000378:metabolism; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D024861:Genetic Enhancement / Q000379:methods*; D060847:Metabolic Engineering / Q000379:methods*; D058086:Microalgae / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics; D059467:Transcriptome / Q000235:genetics*
chemical_list: D020418:Algal Proteins; D001688:Biological Products; D014157:Transcription Factors
keywords: carotenoids; lipids; metabolic engineering; microalgae; nutritional fatty acids; transcription factors