title: Cancer control potential of marine natural product scaffolds through inhibition of tumor cell migration and invasion.
abstract: The marine environment is a reliable source for the discovery of novel treatment options for numerous diseases. Past research efforts toward the discovery of marine-derived anticancer agents have resulted in several commercially available marine-based drugs. The pharmaceutical value of anticancer drugs from marine natural products (MNPs) ranges from US$563 billion to US$5.69 trillion. In this review, we highlight several marine-derived entities with the potential for cancer control and prevention through the inhibition of crucial tumor cell motility and/or migration steps involved in subsequent cancer metastases. This report also covers the major hurdles typically faced by the MNPs research scientific community.
authors.affiliation: Department of Pharmaceutical, Social and Administrative Sciences, D'Youville College School of Pharmacy, Buffalo, NY 14201, USA. Electronic address: muditm@dyc.edu.
authors.forename: Mudit
authors.initials: M
authors.lastname: Mudit
authors.affiliation: Department of Basic Pharmaceutical Sciences, School of Pharmacy, The University of Louisiana at Monroe, Monroe, LA 71201, USA.
authors.forename: Khalid A
authors.initials: KA
authors.lastname: El Sayed
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents; D059001:Aquatic Organisms; D001688:Biological Products; D002465:Cell Movement; D055808:Drug Discovery; D006801:Humans; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products