title: Determination of241Am in Urine Using Sector Field Inductively Coupled Plasma Mass Spectrometry (SF-ICP-MS).
abstract: Quantification of241Am in urine at low levels is important for assessment of individuals' or populations' accidental, environmental, or terrorism-related internal contamination, but no convenient, precise method has been established to rapidly determine these low levels. Here we report a new analytical method to measure241Am as developed and validated at the Centers for Disease Control and Prevention (CDC) by means of the selective retention of Am from urine directly on DGA resin, followed by SF-ICP-MS detection. The method provides rapid results with a Limit of Detection (LOD) of 0.22 pg/L (0.028 Bq/L), which is lower than 1/3 of the C/P CDG for241Am at 5 days post-exposure. The results obtained by this method closely agree with CDC values as measured by Liquid Scintillation Counting, and with National Institute of Standards Technology (NIST) Certified Reference Materials (CRM) target values.
authors.affiliation: Inorganic and Radiation Analytical Toxicology Branch, Centers for Disease Control and Prevention, 4770 Buford HWY, Mail Stop F50, Atlanta, GA 30341, USA.
authors.forename: Ge
authors.initials: G
authors.lastname: Xiao
authors.affiliation: Inorganic and Radiation Analytical Toxicology Branch, Centers for Disease Control and Prevention, 4770 Buford HWY, Mail Stop F50, Atlanta, GA 30341, USA.
authors.forename: David
authors.initials: D
authors.lastname: Saunders
authors.affiliation: Inorganic and Radiation Analytical Toxicology Branch, Centers for Disease Control and Prevention, 4770 Buford HWY, Mail Stop F50, Atlanta, GA 30341, USA.
authors.forename: Robert L
authors.initials: RL
authors.lastname: Jones
authors.affiliation: Inorganic and Radiation Analytical Toxicology Branch, Centers for Disease Control and Prevention, 4770 Buford HWY, Mail Stop F50, Atlanta, GA 30341, USA.
authors.forename: Kathleen L
authors.initials: KL
authors.lastname: Caldwell