title: A Pair of Oviduct-Born Pickpocket Neurons Important for Egg-Laying in Drosophila melanogaster.
abstract: During copulation, male Drosophila transfers Sex Peptide (SP) to females where it acts on internal sensory neurons expressing pickpocket (ppk). These neurons induce a post-mating response (PMR) that includes elevated egg-laying and refractoriness to re-mating. Exactly how ppk neurons regulate the different aspects of the PMR, however, remains unclear. Here, we identify a small subset of the ppk neurons which requires expression of a pre-mRNA splicing factor CG3542 for egg-laying, but not refractoriness to mating. We identify two CG3542-ppk expressing neurons that innervate the upper oviduct and appear to be responsible for normal egg-laying. Our results suggest specific subsets of the ppk neurons are responsible for each PMR component.
authors.affiliation: School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
authors.forename: Hyunjin
authors.initials: H
authors.lastname: Lee
authors.affiliation: School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
authors.forename: Hyun Woo
authors.initials: HW
authors.lastname: Choi
authors.affiliation: School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
authors.forename: Chen
authors.initials: C
authors.lastname: Zhang
authors.affiliation: School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
authors.forename: Zee-Yong
authors.initials: ZY
authors.lastname: Park
authors.affiliation: School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
authors.forename: Young-Joon
authors.initials: YJ
authors.lastname: Kim
mesh_terms: D000818:Animals; D002460:Cell Line; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000502:physiology*; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects; D008297:Male; D010058:Oviposition / Q000187:drug effects; D010455:Peptides / Q000494:pharmacology; D010766:Phosphorylation; D040901:Proteomics / Q000379:methods*; D011984:Sensory Receptor Cells / Q000378:metabolism / Q000502:physiology*; D012726:Sexual Behavior, Animal; D015222:Sodium Channels / Q000378:metabolism
chemical_list: C000614780:CG3542 protein, Drosophila; D029721:Drosophila Proteins; D010455:Peptides; D015222:Sodium Channels
keywords: CG3542; egg-laying; phosphoprotein; pickpocket; post mating response; sex peptide