title: Evaluation of the characterization of thrombi in vitro by optical coherence tomography.
abstract: OBJECTIVE
  The purpose of this study was to provide a new assessable method of the optical coherence tomography (OCT) in characterization of thrombi with different concentrations of red blood cell (RBC).
  
  
  RESULTS
  A series of thrombus models were constructed by using human blood in vitro. The thrombi were made by using human blood with different concentration of RBC (from 1% to 35%). Then tip of an FD-OCT catheter was put on the top of the thrombus to scan. After OCT being performed, all the acquired images were processed by a newly developed software to analyze the RBC levels related thrombus characteristics including attenuation, backscattering and light penetration depth. The attenuation was correlated with RBC concentration up to 9%. However, no apparent change was observed in thrombus with RBC concentration range from 10% to 35%. The same trend was seen in backscattering and penetration depth.
  
  
  CONCLUSIONS
  FD-OCT is able to detect thrombus with different RBC concentrations up to 9%.
authors.affiliation: Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Department of Cardiology, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Guang
authors.initials: G
authors.lastname: Yang
authors.affiliation: Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Department of Cardiology, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Zhang
authors.affiliation: The 3rd Department of Infectious Diseases, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
authors.forename: Qingyang
authors.initials: Q
authors.lastname: Meng
authors.affiliation: The 3rd Department of Internal Medicine, Fujin Central Hospital, Fujin, Heilongjiang Province, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Ma
authors.affiliation: Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Department of Cardiology, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Huai
authors.initials: H
authors.lastname: Yu
authors.affiliation: Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Department of Cardiology, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Ren
authors.affiliation: Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Department of Cardiology, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Lv
authors.affiliation: Goodman, 5F KDX Nagoya Salae Building 5-3, 4-Chome, Sakae, Naka-ku, Nagoya, 460-0008, Japan.
authors.forename: Shaosong
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Department of Cardiology, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address: dryangshuang@126.com.
authors.forename: Shuang
authors.initials: S
authors.lastname: Yang
authors.affiliation: Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Department of Cardiology, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address: yubodr@163.com.
authors.forename: Bo
authors.initials: B
authors.lastname: Yu
mesh_terms: D004906:Erythrocyte Count / Q000379:methods; D006801:Humans; D008955:Models, Cardiovascular; D009203:Myocardial Infarction / Q000175:diagnosis*; D015203:Reproducibility of Results; D012107:Research Design; D013927:Thrombosis / Q000000981:diagnostic imaging* / Q000473:pathology; D041623:Tomography, Optical Coherence / Q000379:methods*
keywords: Erythrocyte; Optical coherence tomography; Thrombus