title: Prognosis of Ischemic Stroke With Newly Diagnosed Diabetes Mellitus According to Hemoglobin A1c Criteria in Chinese Population.
abstract: Hemoglobin A1c (HbA1c) was recommended to diagnose diabetes mellitus, but whether newly diagnosed diabetes mellitus (NDDM) according to the new criteria was associated with stroke prognosis was unclear. We aimed to investigate the prognosis of ischemic stroke with NDDM according to the new criteria.
  
  
  
  Ischemic stroke without a diabetes mellitus history in the survey on Abnormal Glucose Regulation in Patients With Acute Stroke Across China were included in the analysis. NDDM was defined as fasting plasma glucose ≥7.0 mmol/L, 2-hour oral glucose tolerance test ≥11.1 mmol/L, or HbA1c ≥6.5%, and NDDM was divided into group 1, diagnosed by glucose criteria (fasting plasma glucose ≥7.0 mmol/L or 2-hour oral glucose tolerance test ≥11.1 mmol/L with/without HbA1c ≥6.5%), or group 2, diagnosed by single high HbA1c (fasting plasma glucose <7.0 mmol/L, 2-hour oral glucose tolerance test <11.1 mmol/L, and HbA1c ≥6.5%). The association between NDDM and 1-year prognosis (mortality, stroke recurrence, and poor functional outcome [modified Rankin scale score 3-6]) was estimated.
  
  
  
  Among 1251 ischemic stroke patients, 539 were NDDM and 141 of NDDM with single high HbA1c. NDDM was an independent risk factor for 1-year mortality (hazard ratio, 1.12; 95% confidence interval, 1.001-1.26), stroke recurrence (hazard ratio, 1.14; 95% confidence interval, 1.01-1.28), and poor functional outcome (odds ratio, 2.58; 95% confidence interval, 1.95-3.43) compared with non-diabetes mellitus. Nevertheless, NDDM with single high HbA1c was not significantly associated with 1-year prognosis for all end points (P>0.05 for all).
  
  
  
  NDDM by new criteria was associated with poor prognosis at 1 year after ischemic stroke; however, NDDM with single high HbA1c did not predict a poor prognosis.
authors.affiliation: From the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); China National Clinical Research Center for Neurological Diseases, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China (Y.P., Y.H.); Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China (Y.P., Y.H.); and Department of Medicine, University of British Columbia, Vancouver, Canada (L.G.).
authors.forename: Jing
authors.initials: J
authors.lastname: Jing
authors.affiliation: From the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); China National Clinical Research Center for Neurological Diseases, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China (Y.P., Y.H.); Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China (Y.P., Y.H.); and Department of Medicine, University of British Columbia, Vancouver, Canada (L.G.).
authors.forename: Yuesong
authors.initials: Y
authors.lastname: Pan
authors.affiliation: From the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); China National Clinical Research Center for Neurological Diseases, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China (Y.P., Y.H.); Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China (Y.P., Y.H.); and Department of Medicine, University of British Columbia, Vancouver, Canada (L.G.).
authors.forename: Xingquan
authors.initials: X
authors.lastname: Zhao
authors.affiliation: From the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); China National Clinical Research Center for Neurological Diseases, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China (Y.P., Y.H.); Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China (Y.P., Y.H.); and Department of Medicine, University of British Columbia, Vancouver, Canada (L.G.).
authors.forename: Huaguang
authors.initials: H
authors.lastname: Zheng
authors.affiliation: From the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); China National Clinical Research Center for Neurological Diseases, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China (Y.P., Y.H.); Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China (Y.P., Y.H.); and Department of Medicine, University of British Columbia, Vancouver, Canada (L.G.).
authors.forename: Qian
authors.initials: Q
authors.lastname: Jia
authors.affiliation: From the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); China National Clinical Research Center for Neurological Diseases, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China (Y.P., Y.H.); Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China (Y.P., Y.H.); and Department of Medicine, University of British Columbia, Vancouver, Canada (L.G.).
authors.forename: Hao
authors.initials: H
authors.lastname: Li
authors.affiliation: From the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); China National Clinical Research Center for Neurological Diseases, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China (Y.P., Y.H.); Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China (Y.P., Y.H.); and Department of Medicine, University of British Columbia, Vancouver, Canada (L.G.).
authors.forename: Ling
authors.initials: L
authors.lastname: Guan
authors.affiliation: From the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); China National Clinical Research Center for Neurological Diseases, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China (Y.P., Y.H.); Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China (Y.P., Y.H.); and Department of Medicine, University of British Columbia, Vancouver, Canada (L.G.).
authors.forename: Liping
authors.initials: L
authors.lastname: Liu
authors.affiliation: From the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); China National Clinical Research Center for Neurological Diseases, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China (Y.P., Y.H.); Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China (Y.P., Y.H.); and Department of Medicine, University of British Columbia, Vancouver, Canada (L.G.).
authors.forename: Chunxue
authors.initials: C
authors.lastname: Wang
authors.affiliation: From the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); China National Clinical Research Center for Neurological Diseases, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China (Y.P., Y.H.); Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China (Y.P., Y.H.); and Department of Medicine, University of British Columbia, Vancouver, Canada (L.G.).
authors.forename: Xia
authors.initials: X
authors.lastname: Meng
authors.affiliation: From the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); China National Clinical Research Center for Neurological Diseases, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China (Y.P., Y.H.); Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China (Y.P., Y.H.); and Department of Medicine, University of British Columbia, Vancouver, Canada (L.G.).
authors.forename: Yan
authors.initials: Y
authors.lastname: He
authors.affiliation: From the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); China National Clinical Research Center for Neurological Diseases, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China (Y.P., Y.H.); Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China (Y.P., Y.H.); and Department of Medicine, University of British Columbia, Vancouver, Canada (L.G.).
authors.forename: Yilong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: From the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); China National Clinical Research Center for Neurological Diseases, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China (J.J., Y.P., X.Z., H.Z., Q.J., H.L., L.L., C.W., X.M., Yilong Wang, Yongjun Wang); Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China (Y.P., Y.H.); Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China (Y.P., Y.H.); and Department of Medicine, University of British Columbia, Vancouver, Canada (L.G.). yongjunwang1962@gmail.com yilong528@gmail.com.
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D002545:Brain Ischemia / Q000097:blood / Q000150:complications / Q000401:mortality*; D002681:China; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D005260:Female; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors; D020521:Stroke / Q000097:blood / Q000150:complications / Q000401:mortality*
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human
keywords: diabetes mellitus; glucose; prognosis; risk factor; stroke