title: [Not Available].
abstract: Advances in lung transplantation allow the women of childbearing age to consider becoming mothers. When planning to become pregnant, a therapeutic drug management of immunosuppressive drugs and associated therapies is required. It must take into account teratogenic and fetotoxic drugs, as well as pharmacokinetic changes encountered during pregnancy. Increasingly data are currently available on the management of immunosuppressive drugs and associated therapies during pregnancy. We report the case management of drug therapy before and during pregnancy in two patients after a lung or heart-lung transplantation. To prevent the emergence of complications for mother and child, a literature review has been necessary to manage drug therapies of each patient.
authors.affiliation: Pôle Pharmacie, Centre Hospitalier Universitaire de Grenoble, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Zecchini
authors.affiliation: Pôle Pharmacie, Centre Hospitalier Universitaire de Grenoble, France; Université Grenoble Alpes, CNRS/ThEMAS TIMC UMR 5525, Grenoble, France. Electronic address: SChanoine@chu-grenoble.fr.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Chanoine
authors.affiliation: Pôle Pharmacie, Centre Hospitalier Universitaire de Grenoble, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Chapuis
authors.affiliation: Clinique Universitaire de Pneumologie, Centre Hospitalier Universitaire de Grenoble, France.
authors.forename: Johanna
authors.initials: J
authors.lastname: Claustre
authors.affiliation: Centre Régional de Pharmacovigilance, Grenoble, France.
authors.forename: Edith
authors.initials: E
authors.lastname: Schir
authors.affiliation: Pôle Pharmacie, Centre Hospitalier Universitaire de Grenoble, France; Université Grenoble Alpes, CNRS/ThEMAS TIMC UMR 5525, Grenoble, France.
authors.forename: Benoît
authors.initials: B
authors.lastname: Allenet
authors.affiliation: Clinique Universitaire de Pneumologie, Centre Hospitalier Universitaire de Grenoble, France.
authors.forename: Christel Saint
authors.initials: CS
authors.lastname: Raymond
authors.affiliation: Pôle Pharmacie, Centre Hospitalier Universitaire de Grenoble, France; Université Grenoble Alpes, CNRS/ThEMAS TIMC UMR 5525, Grenoble, France.
authors.forename: Pierrick
authors.initials: P
authors.lastname: Bedouch
keywords: drugs; grossesse; immunosuppressants; immunosuppresseurs; lung transplantation; médicaments; pregnancy; teratogenicity; transplantation pulmonaire; tératogénicité