title: The Genetics of Drug Hypersensitivity Reactions.
abstract: DHRs are induced by various mechanisms and encompass a heterogeneous set of potentially life-threatening clinical entities. In addition to environmental effects, individual factors play a key role in this intricate puzzle. However, despite commendable efforts in recent years to identify individual predisposing factors, our knowledge of the genetic basis of these reactions remains incomplete. In this manuscript, we summarize current research on the genetics of DHRs, focusing on specific immune-mediated reactions (immediate and nonimmediate) and on pharmacologically mediated reactions (cross-intolerance to nonsteroidal anti-inflammatory drugs). We also provide some thoughts on potential technological approaches that would help us to decipher the molecular mechanisms underlying DHRs. We believe this manuscript will be of interest not only for allergists and basic researchers in the field, but also for clinicians from various areas of expertise who manage these reactions in their clinical practice.
authors.affiliation: Research Laboratory, IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain.|Allergy Unit, IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: Cornejo-García
authors.affiliation: Research Laboratory, IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Jurado-Escobar
authors.affiliation: Allergy Unit, IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Doña
authors.affiliation: Research Laboratory, IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain.
authors.forename: J R
authors.initials: JR
authors.lastname: Perkins
authors.affiliation: Department of Pharmacology, University of Extremadura, Caceres, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: Agúndez
authors.affiliation: Department of Pharmacology, University of Extremadura, Caceres, Spain.
authors.forename: E
authors.initials: E
authors.lastname: García-Martín
authors.affiliation: Genetics Unit, Department of Cell Biology, Genetics and Physiology, Faculty of Sciences, Malaga University, Malaga, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Viguera
authors.affiliation: Allergy Service, Infanta Leonor University Hospital, Madrid, Spain.
authors.forename: N
authors.initials: N
authors.lastname: Blanca-López
authors.affiliation: Allergy Service, Infanta Leonor University Hospital, Madrid, Spain.
authors.forename: G
authors.initials: G
authors.lastname: Canto
authors.affiliation: Allergy Unit, IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Blanca
mesh_terms: D004342:Drug Hypersensitivity / Q000235:genetics*; D055106:Genome-Wide Association Study; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D007073:Immunoglobulin E
keywords: Cross-intolerance; Drug hypersensitivity; Genome-wide association study; Immediate and nonimmediate reactions; Single-nucleotide polymorphisms