title: Possible role of Epoxyeicosatrienoic acid in prevention of oxidative stress mediated neuroinflammation in Parkinson disorders.
abstract: Parkinson's disease (PD) is a multifactorial neurodegenerative disease involving oxidative stress, neuroinflammation and apoptosis. Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites and they play a role in cytoprotection by modulating various cell signaling pathways. This cytoprotective role of EETs are well established in cerebral stroke, cardiac failure, and hypertension, and it is due to their ability to attenuate oxidative stress, endoplasmic reticulum stress, inflammation, caspase activation and apoptosis. The actions of EETs in brain closely parallel the effects which is observed in the peripheral tissues. Since many of these effects could potentially contribute to neuroprotection, EETs are, therefore, one of the potential therapeutic candidates in PD. Therefore, by increasing the half life of endogenous EETs in vivo via inhibition of sEH, its metabolizing enzyme can, therefore, constitutes an important therapeutic strategy in PD.
authors.affiliation: Department of Pharmacology, JSS College of Pharmacy (A Constituent College of JSS University, Mysore), Ootacamund, Tamilnadu, India.
authors.forename: Navya
authors.initials: N
authors.lastname: Lakkappa
authors.affiliation: Department of Pharmacology, JSS College of Pharmacy (A Constituent College of JSS University, Mysore), Ootacamund, Tamilnadu, India. Electronic address: praveentk7812@gmail.com.
authors.forename: Praveen T
authors.initials: PT
authors.lastname: Krishnamurthy
authors.affiliation: Department of Entomology and Nematology, and Comprehensive Cancer Research Center, University of California, Davis, CA, USA.
authors.forename: Bruce D
authors.initials: BD
authors.lastname: Hammock
authors.affiliation: Department of Crystallography and Biophysics, University of Madras, Guindy Campus, Chennai, India.
authors.forename: D
authors.initials: D
authors.lastname: Velmurugan
authors.affiliation: Department of Neurochemistry, National Institute of Mental Health & Neuro Sciences, Bangalore, India.
authors.forename: M M Srinivas
authors.initials: MM
authors.lastname: Bharath
mesh_terms: D000818:Animals; D017209:Apoptosis; D016718:Arachidonic Acid / Q000737:chemistry; D001095:Arachidonic Acids / Q000502:physiology*; D019610:Cytoprotection; D059290:Dopaminergic Neurons / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism; D059865:Endoplasmic Reticulum Stress; D006801:Humans; D006973:Hypertension / Q000378:metabolism; D007249:Inflammation / Q000378:metabolism*; D051379:Mice; D008962:Models, Theoretical; D000066829:Neuroprotection; D018384:Oxidative Stress; D010300:Parkinson Disease / Q000378:metabolism*; D015398:Signal Transduction; D012995:Solubility
chemical_list: D001095:Arachidonic Acids; D016718:Arachidonic Acid
keywords: Apoptosis; Cytochrome P450; EETs; Neuroinflammation; Neuroprotection; Oxidative stress; PD; sEH