title: Peromyscus as a model of human disease.
abstract: Animals of the genus Peromyscus have been a particularly informative model for many areas of study, including behavior, evolution, anatomy, physiology and genetics. While their use in modeling human disease and pathology has been relatively restricted, certain qualities of Peromyscine mice may make them a good candidate for such studies. Pathophysiological conditions where Peromyscus may be of particular value involve aging, reactive oxygen species-associated pathologies, metabolism and detoxification, diabetes, and certain cancers. In this review article we will summarize pathological conditions where Peromyscus have been used effectively, we will discuss factors limiting the use of Peromyscus in studying pathology and we will indicate areas at which the use of this model may be of special value.
authors.affiliation: Department of Drug Discovery and Biomedical Sciences, University of South Carolina, SC, USA; Peromyscus Genetic Stock Center, Office of Research, University of South Carolina, SC, USA.
authors.forename: Amanda
authors.initials: A
authors.lastname: Havighorst
authors.affiliation: Peromyscus Genetic Stock Center, Office of Research, University of South Carolina, SC, USA.
authors.forename: Janet
authors.initials: J
authors.lastname: Crossland
authors.affiliation: Department of Drug Discovery and Biomedical Sciences, University of South Carolina, SC, USA; Peromyscus Genetic Stock Center, Office of Research, University of South Carolina, SC, USA; Department of Biochemistry, University of Athens Medical School, Athens, Greece. Electronic address: kiarish@sccp.sc.edu.
authors.forename: Hippokratis
authors.initials: H
authors.lastname: Kiaris
mesh_terms: D000222:Adaptation, Physiological; D000375:Aging / Q000502:physiology; D000818:Animals; D063646:Carcinogenesis / Q000473:pathology; D004195:Disease Models, Animal; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology; D010542:Peromyscus / Q000502:physiology*
keywords: Alcohol metabolism; Cancer; Diabetes; Hypoxia; Model organism; Oxidative stress; Pathology; Peromyscus