title: Seroprevalence of Antibodies against Measles, Rubella and Varicella among Asylum Seekers Arriving in Lower Saxony, Germany, November 2014-October 2015.
abstract: The number of asylum seekers arriving in Germany has increased rapidly since 2014 and cases of vaccine-preventable diseases at reception centres were reported. Asylum seekers 12 years and older arriving in Lower Saxony were serologically screened for antibodies against measles, rubella and varicella between November 2014 and October 2015. We calculated the seroprevalence from the screening data by disease, country of origin and age group and compared them to literature-based herd immunity thresholds in order to identify immunisation gaps. In total, 23,647 specimens were included in our study. Although the vast majority of asylum seekers tested positive for antibodies against measles, rubella and varicella, the seroprevalences were not sufficient to ensure herd immunity. The seroprevalences varied substantially between countries of origin and increased with age. Immunisation of asylum seekers against measles, rubella and varicella is needed and the detailed information on seroprevalences among subgroups of asylum seekers can be used for targeted immunisations at reception centres.
authors.affiliation: Governmental Institute of Public Health of Lower Saxony (Nieders&#228;chsisches Landesgesundheitsamt, NLGA), Roesebeckstraße 4-6, Hanover 30449, Germany. salla.toikkanen@Nlga.Niedersachsen.de.|European Programme for Intervention Epidemiology Training (EPIET), European Centre for Disease Prevention and Control (ECDC), Tomtebodav&#228;gen 11a, Stockholm 17183, Sweden. salla.toikkanen@Nlga.Niedersachsen.de.
authors.forename: Salla E
authors.initials: SE
authors.lastname: Toikkanen
authors.affiliation: Governmental Institute of Public Health of Lower Saxony (Nieders&#228;chsisches Landesgesundheitsamt, NLGA), Roesebeckstraße 4-6, Hanover 30449, Germany. Armin.Baillot@nlga.Niedersachsen.de.
authors.forename: Armin
authors.initials: A
authors.lastname: Baillot
authors.affiliation: Governmental Institute of Public Health of Lower Saxony (Nieders&#228;chsisches Landesgesundheitsamt, NLGA), Roesebeckstraße 4-6, Hanover 30449, Germany. Johannes.Dreesman@nlga.Niedersachsen.de.
authors.forename: Johannes
authors.initials: J
authors.lastname: Dreesman
authors.affiliation: Governmental Institute of Public Health of Lower Saxony (Nieders&#228;chsisches Landesgesundheitsamt, NLGA), Roesebeckstraße 4-6, Hanover 30449, Germany. Elke.Mertens@nlga.Niedersachsen.de.
authors.forename: Elke
authors.initials: E
authors.lastname: Mertens
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000914:Antibodies, Viral; D002644:Chickenpox / Q000276:immunology*; D002648:Child; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008297:Male; D008457:Measles / Q000276:immunology*; D008875:Middle Aged; D012036:Refugees / Q000706:statistics & numerical data*; D012409:Rubella / Q000276:immunology*; D016036:Seroepidemiologic Studies; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral
keywords: IgG; asylum seekers; immunisation; measles; rubella; seroprevalence; varicella