title: Allergic Conjunctivitis and the Associated Risk of Migraine Among Children: A Nationwide Population-based Cohort Study.
abstract: OBJECTIVE
  To investigate the risk of migraine in children with allergic conjunctivitis (AC).
  
  
  METHODS
  In this population-based cohort study, 309 138 children with AC and 309 138 non-AC controls were included between 2000 and 2007. By 2008 end, the incidences of migraine in both cohorts, and the AC-to-non-AC cohort hazard ratios (HRs) were measured.
  
  
  RESULTS
  The incidence of migraine during the study period was 1.92-fold higher in the AC cohort than in the non-AC cohort. The risk was greater for boys with AC and children aged <6 years. The mean time-interval between physician-diagnosed AC to physician-diagnosed migraine was 3.67 years (SD = 2.19).The risk of migraine development in the AC cohort increased with follow-up time and was highest during 4-5 years after AC diagnosis. The children with AC more likely had migraine without than with aura.
  
  
  CONCLUSIONS
  Children with AC had a higher incidence and subsequent risk of migraine.
authors.affiliation: a Children's Hospital of China Medical University Hospital , Taichung , Taiwan.
authors.forename: I-Chung
authors.initials: IC
authors.lastname: Wang
authors.affiliation: b Department of Pediatrics , Chung Shan Medical University Hospital , Taichung , Taiwan.|c Institute of Medicine, Chung Shan Medical University , Taichung , Taiwan.
authors.forename: Jeng-Dau
authors.initials: JD
authors.lastname: Tsai
authors.affiliation: d Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine , China Medical University Hospital , Taichung , Taiwan.|e School of Medicine, China Medical University , Taichung , Taiwan.
authors.forename: Te-Chun
authors.initials: TC
authors.lastname: Shen
authors.affiliation: f Management Office for Health Data, China Medical University Hospital , Taichung , Taiwan.|g Institute of Biostatistics, China Medical University , Taichung , Taiwan.
authors.forename: Cheng-Li
authors.initials: CL
authors.lastname: Lin
authors.affiliation: g Institute of Biostatistics, China Medical University , Taichung , Taiwan.
authors.forename: Tsai-Chung
authors.initials: TC
authors.lastname: Li
authors.affiliation: a Children's Hospital of China Medical University Hospital , Taichung , Taiwan.|e School of Medicine, China Medical University , Taichung , Taiwan.
authors.forename: Chang-Ching
authors.initials: CC
authors.lastname: Wei
mesh_terms: D002648:Child; D015331:Cohort Studies; D003233:Conjunctivitis, Allergic / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008881:Migraine Disorders / Q000175:diagnosis / Q000453:epidemiology*; D009313:National Health Programs / Q000706:statistics & numerical data; D016016:Proportional Hazards Models; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology
keywords: Allergic conjunctivitis; children; cohort study; migraine