title: Strategies to improve phase-stability of ultrafast swept source optical coherence tomography for single shot imaging of transient mechanical waves at 16 kHz frame rate.
abstract: We present single-shot phase-sensitive imaging of propagating mechanical waves within tissue, enabled by an ultrafast optical coherence tomography (OCT) system powered by a 1.628 MHz Fourier domain mode-locked (FDML) swept laser source. We propose a practical strategy for phase-sensitive measurement by comparing the phases between adjacent OCT B-scans, where the B-scan contains a number of A-scans equaling an integer number of FDML buffers. With this approach, we show that micro-strain fields can be mapped with ∼3.0 nm sensitivity at ∼16 000 fps. The system's capabilities are demonstrated on porcine cornea by imaging mechanical wave propagation launched by a pulsed UV laser beam, promising non-contact, real-time, and high-resolution optical coherence elastography.
authors.affiliation: Department of Bioengineering, University of Washington , Seattle, Washington 98195, USA.
authors.forename: Shaozhen
authors.initials: S
authors.lastname: Song
authors.affiliation: Department of Bioengineering, University of Washington , Seattle, Washington 98195, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.affiliation: Department of Bioengineering, University of Washington , Seattle, Washington 98195, USA.
authors.forename: Bao-Yu
authors.initials: BY
authors.lastname: Hsieh
authors.affiliation: Department of Bioengineering, University of Washington , Seattle, Washington 98195, USA.
authors.forename: Ivan
authors.initials: I
authors.lastname: Pelivanov
authors.forename: Tueng T
authors.initials: TT
authors.lastname: Shen
authors.affiliation: Department of Bioengineering, University of Washington , Seattle, Washington 98195, USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: O'Donnell
authors.forename: Ruikang K
authors.identifier: 0000-0001-6823-9139
authors.initials: RK
authors.lastname: Wang