title: Overgeneral autobiographical memory at baseline predicts depressive symptoms at follow-up in patients with first-episode depression.
abstract: Previous studies have shown that overgeneral autobiographical memory (OGM) is a characteristic of depression. However, there are no studies to explore the association between baseline OGM and depressive symptoms at follow-up in patients with first-episode depression (FE). This study investigated whether baseline OGM predicts depressive symptoms at follow-up in patients with FE. We recruited 125 patients with FE. The participants were divided into remitted group and non-remitted group according to the severity of their depression at 12 months follow-up. The measures consisted of the 17-item Hamilton Depression Rating Scale, Ruminative Response Scale, and Autobiographical Memory Test. Hierarchical linear regression analyses and bootstrap mediation analyses were conducted. The results showed that non-remitted patients had more OGM at baseline. Baseline OGM predicted depressive symptoms at follow-up in patients with FE. Rumination mediated the relationship between baseline OGM and depressive symptoms at follow-up. Our findings highlight OGM as a vulnerability factor involved in the maintenance of depression in patients with FE.
authors.affiliation: Department of Psychosomatic Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200092, China.
authors.forename: Yansong
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Psychosomatic Medicine, Wuxi Mental Health Center Hospital, Affiliated to Nanjing Medical University, Wuxi 214151 Jiangsu Province, China.
authors.forename: Fuquan
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Department of Psychosomatic Medicine, Wuxi Mental Health Center Hospital, Affiliated to Nanjing Medical University, Wuxi 214151 Jiangsu Province, China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Psychosomatic Medicine, Wuxi Mental Health Center Hospital, Affiliated to Nanjing Medical University, Wuxi 214151 Jiangsu Province, China.
authors.forename: Leiming
authors.initials: L
authors.lastname: Cao
authors.affiliation: Department of Psychosomatic Medicine, Wuxi Mental Health Center Hospital, Affiliated to Nanjing Medical University, Wuxi 214151 Jiangsu Province, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Psychiatry, The Third People's Hospital of Kunshan, Kunshan 215300, Jiangsu Province, China.
authors.forename: Aiguo
authors.initials: A
authors.lastname: Na
authors.affiliation: Department of Psychiatry, Mental Hospital of Jiangsu Province Prison Administration, Nanjing 210000, Jiangsu Province, China.
authors.forename: Yujun
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Psychosomatic Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200092, China. Electronic address: zhaoxdmail@163.com.
authors.forename: Xudong
authors.initials: X
authors.lastname: Zhao
mesh_terms: D000328:Adult; D003863:Depression / Q000175:diagnosis* / Q000523:psychology; D003866:Depressive Disorder / Q000175:diagnosis* / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D061212:Memory, Episodic; D008875:Middle Aged; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D055815:Young Adult
keywords: Autobiographical memory; Depression; Major depressive disorder; Rumination