title: Neurobrucellosis and venous sinus thrombosis: an uncommon association.
abstract: Brucellosis is a commonly diagnosed zoonosis and neurological involvement is rare. A 30-year-old woman presented with a pulsatile headache that was exacerbated by the Valsalva maneuver and refractory to analgesic therapy. The patient also had nausea, cough, and coryza that evolved over 7 days. The neurological examination was unremarkable. Thrombosis of the lateral and sigmoid sinus and ipsilateral internal jugular vein were diagnosed and anticoagulation therapy was started. Brucella spp was identified in a sample of cerebrospinal fluid (CSF); five months after treatment with rifampicin and doxycycline, CSF was sterile. Cerebral venous thrombosis is a very uncommon sign of brucellosis.
authors.affiliation: Internato Médico em Oncologia Médica, Serviço de Oncologia Médica, Centro Hospitalar de Trás-os-Montes e Alto Douro, Vila Real, Portugal.
authors.forename: Joana Isabel da Silva
authors.initials: JI
authors.lastname: Lima
authors.affiliation: Internato Médico em Medicina Interna, Serviço de Medicina Interna, Centro Hospitalar de Trás-os-Montes e Alto Douro, Vila Real, Portugal.
authors.forename: Cátia Filipa Gomes
authors.initials: CF
authors.lastname: Canelas
authors.affiliation: Internato Médico em Neurologia, Serviço de Neurologia, Centro Hospitalar de Trás-os-Montes e Alto Douro, Vila Real, Portugal.
authors.forename: Andreia Sofia de Sousa Botelho Trindade
authors.initials: AS
authors.lastname: Veiga
authors.affiliation: Serviço de Medicina Interna, Centro Hospitalar de Trás-os-Montes e Alto Douro, Vila Real, Portugal.
authors.forename: Dina Maria Mota
authors.initials: DM
authors.lastname: Carvalho
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002006:Brucellosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D004318:Doxycycline / Q000627:therapeutic use; D005260:Female; D006801:Humans; D012293:Rifampin / Q000627:therapeutic use; D012851:Sinus Thrombosis, Intracranial / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D004318:Doxycycline; D012293:Rifampin