title: Multicentric Benign Epithelial Inclusions in a Free-ranging Risso's Dolphin (Grampus griseus).
abstract: This report describes the histological and immunohistochemical features of multicentric, benign, epithelial inclusions (BEIs) in a free-ranging, adult, female Risso's dolphin (Grampus griseus). The differential diagnoses included ectopic hamartomatous epithelial inclusions, non-Müllerian choristoma, Müllerian choristoma and low-grade metastatic carcinoma/mesothelioma. The most likely diagnosis of such BEIs was multicentric, embolic, reactive mesothelium, as suggested by cytomorphological and immunophenotypical features of the BEIs, the occurrence of focal pleural rupture and the immunophenotype of the pleural mesothelium. The former represents a pathological condition not previously reported in a marine mammal species, rarely described in animals, and relatively infrequently recognized in man.
authors.affiliation: Veterinary Histology and Pathology, Institute for Animal Health, Veterinary College, University of Las Palmas de Gran Canaria, Trasmontaña s/n, Arucas, Gran Canaria, Spain; Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA. Electronic address: josue.diaz101@alu.ulpgc.es.
authors.forename: J
authors.initials: J
authors.lastname: Diaz-Delgado
authors.affiliation: Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.
authors.forename: O
authors.initials: O
authors.lastname: Quesada-Canales
authors.affiliation: Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.
authors.forename: M
authors.initials: M
authors.lastname: Arbelo
authors.affiliation: Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.
authors.forename: E
authors.initials: E
authors.lastname: Sierra
authors.affiliation: Veterinary Histology and Pathology, Institute for Animal Health, Veterinary College, University of Las Palmas de Gran Canaria, Trasmontaña s/n, Arucas, Gran Canaria, Spain.
authors.forename: J F
authors.initials: JF
authors.lastname: Edwards
authors.affiliation: Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.
authors.forename: A
authors.initials: A
authors.lastname: Suarez-Bonnet
authors.affiliation: Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.
authors.forename: C
authors.initials: C
authors.lastname: Santana-Suarez
authors.affiliation: Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.
authors.forename: A
authors.initials: A
authors.lastname: Espinosa de Los Monteros
authors.affiliation: Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.
authors.forename: A
authors.initials: A
authors.lastname: Fernandez
mesh_terms: D000818:Animals; D004289:Dolphins; D004848:Epithelium / Q000473:pathology*; D005260:Female; D002479:Inclusion Bodies / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology*
keywords: Risso's dolphin; epithelial inclusions; reactive mesothelium