title: Palladium-Catalyzed Asymmetric Arylation of Trifluoromethylated/Perfluoroalkylated 2-Quinazolinones with High Enantioselectivity.
abstract: Asymmetric arylation of 4-fluoroalkyl-2-quinazolinone derivatives with arylboronic acids proceeded smoothly in the presence of a cationic palladium catalyst (1 mol %) coordinated with a chiral phosphinooxazoline (phox) ligand to create the corresponding fluorine-containing arylated dihydroquinazolinones in high yields and with greater than 99 % ee.
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543, Singapore.
authors.forename: Bo
authors.initials: B
authors.lastname: Zhou
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543, Singapore.|School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang, Jiangsu, 212003, China.
authors.forename: Chunhui
authors.initials: C
authors.lastname: Jiang
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543, Singapore.
authors.forename: Vasudeva Rao
authors.initials: VR
authors.lastname: Gandi
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543, Singapore. chmlyx@nus.edu.sg.
authors.forename: Yixin
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543, Singapore. hayashi@ntu.edu.sg.|Institute of Materials Research and Engineering, The Agency for Science, Technology, and Research (ASTAR), 2 Fusionopolis Way, Singapore, 138634, Singapore. hayashi@ntu.edu.sg.|Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore, 637371, Singapore. hayashi@ntu.edu.sg.
authors.forename: Tamio
authors.initials: T
authors.lastname: Hayashi
keywords: asymmetric arylation; fluorinated molecules; palladium; phosphine-oxazoline ligand; quinazolinone