title: Influence of adipocytokines in periprostatic adipose tissue on prostate cancer aggressiveness.
abstract: To evaluate the correlation between the level of adipocytokines expression in periprostatic adipose tissue and the prostate cancer aggressiveness.
  
  
  
  The periprostatic adipose tissues were collected from 30 patients who underwent radical retropubic prostatectomy. The subcutaneous adipose, periprostatic adipose tissues and prostate cancer tissue from the same patient were collected from 10 patients for match research. The expression level of IL-6, Leptin and Adiponectin was detected by immunohistochemistry and by Real-time quantitative PCR in periprostatic adipose tissues.
  
  
  
  There were differences in the positive rates of IL-6, Leptin and Adiponectin expression in the periprostate adipose between prostate cancer and control (P<0.001, P=0.032, 0.003). Nothing but the "IL-6 expression intensity" was seen in difference with the aggressiveness of prostate cancer (P=0.001), and was relevant with the prostate cancer aggressiveness (rs=0.668, P<0.001); The mRNA expression of IL-6 in periprostatic adipose tissues of prostate cancer was higher than that of control (P=0.049), and the mRNA expression of Adiponectin was lower (P<0.0001); IL-6 mRNA expression in periprostate adipose tissue and prostate cancer tissue were higher than that in subcutaneous adipose (P<0.001, P=0.001); IL-6 mRNA expression in periprostate adipose was correlated with that in prostate cancer tissue (r=0.663, p=0.036); Adiponectin mRNA expression in prostate cancer tissue was lower than that in periprostate adipose (P=0.006), and Adiponectin mRNA expression in periprostate adipose was correlated with that in prostate cancer tissue (r=0.707, p=0.022).
  
  
  
  IL-6, Leptin and Adiponectin were expressed in the periprostatic adipose tissues, which constitute the microenvironment of prostate cancer aggressiveness. There might be intimate relationship between periprostate adipose and prostate cancer tissue.
authors.affiliation: Department of Urology, Baotou Central Hospital, Baotou 014040, Inner Mongolia, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Urology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, China. Electronic address: slj20151001@163.com.
authors.forename: Li-Jiang
authors.initials: LJ
authors.lastname: Sun
authors.affiliation: Department of Urology, Baotou Central Hospital, Baotou 014040, Inner Mongolia, China.
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Yang
authors.affiliation: Department of Urology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, China.
authors.forename: Gui-Ming
authors.initials: GM
authors.lastname: Zhang
authors.affiliation: Department of Urology, Baotou Central Hospital, Baotou 014040, Inner Mongolia, China.
authors.forename: Ri-Cha
authors.initials: RC
authors.lastname: Huo
mesh_terms: D054392:Adipokines / Q000378:metabolism*; D000273:Adipose Tissue / Q000378:metabolism*; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism; D020738:Leptin / Q000378:metabolism; D008297:Male; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology*; D012333:RNA, Messenger / Q000378:metabolism
chemical_list: D054392:Adipokines; D015850:Interleukin-6; D020738:Leptin; D012333:RNA, Messenger
keywords: Adipocytokine; Adiponectin; IL-6; Leptin; Periprostatic adipose tissue; Prostate cancer; Tumor aggressiveness