title: [Adult Celiac Disease].
abstract: Celiac disease is an immune-mediated enteropathy in genetically predisposed individuals, triggered by gluten ingestion. Clinical manifestations include intestinal and extraintestinal symptoms. Affected individuals may also be completely asymptomatic. Nevertheless, an early diagnosis is essential in order to prevent long-term complications. Diagnostic approach involves serologic testing for tissue transglutaminase antibodies followed by duodenal biopsy in case of seropositivity. Until now, the only available treatment consists of a strict glute-free diet. Newer therapeutic strategies are currently being evaluated in clinical trials.
authors.affiliation: 1 Klinik und Poliklinik für Innere Medizin, Universitätsspital Zürich.
authors.forename: Natalie
authors.initials: N
authors.lastname: Many
authors.affiliation: 2 Klinik für Gastroenterologie und Hepatologie, Universitätsspital Zürich.
authors.forename: Luc
authors.initials: L
authors.lastname: Biedermann
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood; D002446:Celiac Disease / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology / Q000628:therapy; D055050:Diet, Gluten-Free; D042241:Early Diagnosis; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005983:Glutens / Q000008:administration & dosage / Q000276:immunology; D006683:HLA-DQ Antigens / Q000235:genetics; D006801:Humans; D008875:Middle Aged; D011503:Transglutaminases / Q000276:immunology
chemical_list: D001323:Autoantibodies; D006683:HLA-DQ Antigens; C053186:HLA-DQ2 antigen; C109756:HLA-DQ8 antigen; D005983:Glutens; D011503:Transglutaminases
keywords: Gluten; HLA-DQ2/DQ8 - Gewebs-Transglutaminase-Antikörper; HLA-DQ2/DQ8 - tissue transglutaminase antibodies; Zöliakie; celiac disease; gluten