title: Quantitative (13)C Solid-State NMR Spectra by Multiple-Contact Cross-polarization for Drug Delivery: From Active Principles to Excipients and Drug Carriers.
abstract: In this contribution, we present an analysis of the main parameters influencing the efficiency of the (1)H → (13)C multiple-contact cross-polarization nuclear magnetic resonance (NMR) experiment in the context of solid pharmaceutical materials. Using the optimum experimental conditions, quantitative (13)C NMR spectra are then obtained for porous metal-organic frameworks (potential drug carriers) and for components present in drug formulations (active principle ingredient and excipients, amorphous or crystalline). Finally, we show that mixtures of components can also be quantified with this method and, hence, that it represents an ideal tool for quantification of pharmaceutical formulations by (13)C cross-polarization under magic-angle spinning NMR in the industry as it is robust and easy to set up, much faster than direct (13)C polarization and is efficient for samples at natural abundance.
authors.affiliation: Tectospin, Institut Lavoisier de Versailles, CNRS UMR 8180, Université de Versailles Saint-Quentin en Yvelines, 45 Avenue des Etats-Unis, 78035 Versailles Cedex, France.
authors.forename: Fadila
authors.initials: F
authors.lastname: Saïdi
authors.affiliation: Tectospin, Institut Lavoisier de Versailles, CNRS UMR 8180, Université de Versailles Saint-Quentin en Yvelines, 45 Avenue des Etats-Unis, 78035 Versailles Cedex, France.
authors.forename: Francis
authors.initials: F
authors.lastname: Taulelle
authors.affiliation: Tectospin, Institut Lavoisier de Versailles, CNRS UMR 8180, Université de Versailles Saint-Quentin en Yvelines, 45 Avenue des Etats-Unis, 78035 Versailles Cedex, France; CNRS, CEMHTI UPR3079, Université d'Orléans, F-45071 Orléans, France. Electronic address: charlotte.martineau@uvsq.fr.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Martineau
mesh_terms: D001569:Benzodiazepines / Q000032:analysis; D002247:Carbon Isotopes; D066241:Carbon-13 Magnetic Resonance Spectroscopy / Q000379:methods*; D002626:Chemistry, Pharmaceutical; D056831:Coordination Complexes / Q000032:analysis*; D004337:Drug Carriers / Q000032:analysis*; D005079:Excipients / Q000032:analysis*; D008715:Methionine / Q000032:analysis; D000077152:Olanzapine; D004364:Pharmaceutical Preparations / Q000032:analysis*; D013395:Sucrose / Q000032:analysis; D014633:Valine / Q000032:analysis
chemical_list: D002247:Carbon Isotopes; D056831:Coordination Complexes; D004337:Drug Carriers; D005079:Excipients; D004364:Pharmaceutical Preparations; D001569:Benzodiazepines; D013395:Sucrose; D008715:Methionine; D014633:Valine; D000077152:Olanzapine
keywords: CPMAS; MC-CP; pharmaceutical formulation; quantitative measurement; solid-state NMR