title: The Taming of the TAMs.
abstract: Tumor-associated macrophages and microglia (TAMs) are considered crucial elements in cancer progression. Recent work reveals the molecular mechanisms underlying acquired resistance to colony-stimulating factor-1 receptor (CSF-1R) inhibitors in glioblastoma (GBM) and shows that targeting TAMs with CSF-1R inhibitors leads to an antitumor response in GBM followed by the acquisition of resistance to treatment through the induction of insulin-like growth factor 1 (IGF-1) expression in TAMs.
authors.affiliation: Vall d'Hebron Institute of Oncology, Vall d'Hebron University Hospital, c/Natzaret, 115-117, 08035 Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain. Electronic address: jseoane@vhio.net.
authors.forename: Joan
authors.initials: J
authors.lastname: Seoane
mesh_terms: D000818:Animals; D005909:Glioblastoma / Q000473:pathology; D006801:Humans; D008264:Macrophages / Q000473:pathology*; D017628:Microglia / Q000473:pathology*; D009369:Neoplasms / Q000473:pathology*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D016186:Receptor, Macrophage Colony-Stimulating Factor / Q000037:antagonists & inhibitors / Q000378:metabolism; D015398:Signal Transduction; D059016:Tumor Microenvironment
chemical_list: D019869:Phosphatidylinositol 3-Kinases; D016186:Receptor, Macrophage Colony-Stimulating Factor