title: Cardiovascular disease risk in people with spinal cord injury: is there a possible association between reduced lung function and increased risk of diabetes and hypertension?
abstract: METHODS
  Retrospective, descriptive study of medical files 253 patients with chronic traumatic spinal cord injury (SCI).
  
  
  OBJECTIVE
  To determine the frequency of cardiovascular disease (CVD) risk factors in SCI people, to estimate CVD risk in this population according to the Framingham Risk Score (FRS) and to determine whether reduced lung function parameters are significant predictors of diabetes mellitus (DM) and hypertension.
  
  
  METHODS
  Academic Rehabilitation Hospital.
  
  
  METHODS
  Demographic and clinical records of the patients and lung function parameters were obtained.
  
  
  RESULTS
  The FRS could not be calculated in 26 (10.3%) patients because this tool is designed for adults aged 20 years and older. According to the FRS guideline, ~6.7% of the SCI patients had high risk, 5.9% of them had intermediate risk and 77.1% of the study group had low risk for CVD. Regression analysis showed that impaired lung function parameters (FEV1, FVC and MVV) were significant predictors for the future development of hypertension (odds ratio (OR): 0.483 (0.258-0.903 95% confidence interval (CI)), OR: 0.549 (0.319-0.946 95% CI) and OR: 0.981 (0.965-0.998 95% CI), respectively) and DM (OR: 0.335 (0.140-0.801 95% CI), OR: 0.391 (0.183-0.839 95% CI) and OR: 0.970 (0.947-0.993 95% CI), respectively) in the SCI population.
  
  
  CONCLUSIONS
  This study showed that there might be a significant relationship between reduced lung function and the risk of DM and hypertension in people with SCI. Therefore, systematic measurement of these parameters should be performed in the routine clinical follow-up of SCI patients. Once reduced lung parameters are determined, the higher risk for developing hypertension and DM should be considered.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Ministry of Health, Ankara Physical Medicine and Rehabilitation Training and Research Hospital, Ankara, Turkey.
authors.forename: B F
authors.initials: BF
authors.lastname: Köseoğlu
authors.affiliation: Department of Physical Medicine and Rehabilitation, Ministry of Health, Istanbul Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.
authors.forename: V B
authors.initials: VB
authors.lastname: Safer
authors.affiliation: Department of Physical Medicine and Rehabilitation, Ministry of Health, Ankara Physical Medicine and Rehabilitation Training and Research Hospital, Ankara, Turkey.
authors.forename: Ö
authors.initials: Ö
authors.lastname: Öken
authors.affiliation: Department of Physical Medicine and Rehabilitation, Ministry of Health, Ankara Physical Medicine and Rehabilitation Training and Research Hospital, Ankara, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Akselim
mesh_terms: D000046:Academic Medical Centers; D000328:Adult; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology* / Q000503:physiopathology; D016014:Linear Models; D016015:Logistic Models; D008168:Lung / Q000503:physiopathology*; D008297:Male; D012047:Rehabilitation Centers; D012129:Respiratory Function Tests; D012189:Retrospective Studies; D012307:Risk Factors; D013119:Spinal Cord Injuries / Q000453:epidemiology* / Q000503:physiopathology*