title: Regulation of transcription factors via natural decoys in genomic DNA.
abstract: Eukaryotic genomic DNA contains numerous high-affinity sites for transcription factors. Only a small fraction of these sites directly regulates target genes. Other high-affinity sites can serve as naturally present decoys that sequester transcription factors. Such natural decoys in genomic DNA may provide novel regulatory mechanisms for transcription factors.
authors.affiliation: a Department of Biochemistry and Molecular Biology , University of Texas Medical Branch , Galveston , TX , USA.
authors.forename: Catherine A
authors.initials: CA
authors.lastname: Kemme
authors.affiliation: a Department of Biochemistry and Molecular Biology , University of Texas Medical Branch , Galveston , TX , USA.
authors.forename: Dan
authors.initials: D
authors.lastname: Nguyen
authors.affiliation: a Department of Biochemistry and Molecular Biology , University of Texas Medical Branch , Galveston , TX , USA.
authors.forename: Abhijnan
authors.initials: A
authors.lastname: Chattopadhyay
authors.affiliation: a Department of Biochemistry and Molecular Biology , University of Texas Medical Branch , Galveston , TX , USA.
authors.forename: Junji
authors.initials: J
authors.lastname: Iwahara
mesh_terms: D000818:Animals; D001665:Binding Sites; D002843:Chromatin / Q000235:genetics / Q000378:metabolism; D042002:Chromatin Assembly and Disassembly; D004247:DNA / Q000235:genetics* / Q000378:metabolism*; D019175:DNA Methylation; D005786:Gene Expression Regulation; D016678:Genome; D006801:Humans; D011485:Protein Binding; D012045:Regulatory Sequences, Nucleic Acid; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D002843:Chromatin; D014157:Transcription Factors; D004247:DNA
keywords: decoy; regulatory elements; sequestration; target search; transcription factors