title: Moving from the Dish to the Clinical Practice: A Decade of Lessons and Perspectives from the Pre-Clinical and Clinical Stem Cell Studies for Alzheimer's Disease.
abstract: To date, there is no definitive treatment for Alzheimer's disease (AD). The realm of stem cells is very promising in regenerative medicine, particularly neurodegenerative disorders. Various types of stem cells have been used in multiple trials on AD models, trying to find an innovative management of this disease. In this systematic review, we trace the published preclinical and clinical data throughout the last decade, to show how much knowledge we gained so far in this field and the future perspectives of stem cells in AD treatment.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Neuropsychiatry Program, McGovern Medical School, The University of Texas Health Science Center, Houston, TX, USA.|Regenerative Medicine Program, University of Lübeck, Schleswig-Holstein, Germany.
authors.forename: Haitham
authors.initials: H
authors.lastname: Salem
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Neuropsychiatry Program, McGovern Medical School, The University of Texas Health Science Center, Houston, TX, USA.
authors.forename: Natalia Pessoa
authors.initials: NP
authors.lastname: Rocha
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Neuropsychiatry Program, McGovern Medical School, The University of Texas Health Science Center, Houston, TX, USA.
authors.forename: Gabriela Delevati
authors.initials: GD
authors.lastname: Colpo
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Neuropsychiatry Program, McGovern Medical School, The University of Texas Health Science Center, Houston, TX, USA.
authors.forename: Antonio Lucio
authors.initials: AL
authors.lastname: Teixeira
mesh_terms: D000544:Alzheimer Disease / Q000266:history / Q000601:surgery*; D000818:Animals; D002986:Clinical Trials as Topic / Q000266:history; D016206:Databases, Bibliographic / Q000706:statistics & numerical data; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D033581:Stem Cell Transplantation / Q000379:methods*; D013234:Stem Cells / Q000502:physiology; D057170:Translational Research, Biomedical / Q000266:history / Q000379:methods / Q000706:statistics & numerical data
keywords: Alzheimer’s disease; clinical trails; neurodegenerative diseases; preclinical trials; stem cells