title: Efficacy and safety of ketamine in bipolar depression: A systematic review.
abstract: The depression is the most prevalent state throughout the life of the bipolar patient. Ketamine has been shown to be an effective and rapid treatment for depression. The objective of the present work is to perform a systematic review on the efficacy and safety of ketamine as treatment of bipolar depression, as well as its different patterns of administration. The search found 10 relevant manuscripts that met the inclusion criteria: one clinical trial, 5 cohort studies, and 4 case reports. Intravenous infusion was used in 60% of the studies. According to data, ketamine seems to be an effective and safe treatment for bipolar depression, although the length of its effect is short. Adverse effects observed generally occurred at the time of infusion, and tended to completely disappear within 1-2h. Therefore, more studies are necessary to explore new patterns of administration, as well as on its safety and adverse effects.
authors.affiliation: Servicio de Psiquiatría, Hospital Universitario Araba, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Investigación Sanitaria BIOARABA.OSI Araba, Vitoria, España.
authors.forename: Susana
authors.initials: S
authors.lastname: Alberich
authors.affiliation: Servicio de Psiquiatría, Hospital Universitario Araba, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Investigación Sanitaria BIOARABA.OSI Araba, Vitoria, España; Universidad Nacional de Educación a Distancia (UNED)-Centro Asociado de Vitoria, Vitoria, España.
authors.forename: Mónica
authors.initials: M
authors.lastname: Martínez-Cengotitabengoa
authors.affiliation: Servicio de Psiquiatría, Hospital Universitario Araba, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Investigación Sanitaria BIOARABA.OSI Araba, Vitoria, España; Universidad del País Vasco, Departamento de Neurociencias, Vitoria, España.
authors.forename: Purificación
authors.initials: P
authors.lastname: López
authors.affiliation: Servicio de Psiquiatría, Hospital Universitario Araba, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Investigación Sanitaria BIOARABA.OSI Araba, Vitoria, España; Universidad del País Vasco, Departamento de Neurociencias, Vitoria, España.
authors.forename: Iñaki
authors.initials: I
authors.lastname: Zorrilla
authors.affiliation: Servicio de Psiquiatría, Hospital Universitario Araba, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Investigación Sanitaria BIOARABA.OSI Araba, Vitoria, España.
authors.forename: Nuria
authors.initials: N
authors.lastname: Núñez
authors.affiliation: Unidad de Trastorno Bipolar, Instituto de Neurociencias, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Universidad de Barcelona, Barcelona, España.
authors.forename: Eduard
authors.initials: E
authors.lastname: Vieta
authors.affiliation: Servicio de Psiquiatría, Hospital Universitario Araba, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Investigación Sanitaria BIOARABA.OSI Araba, Vitoria, España; Universidad del País Vasco, Departamento de Neurociencias, Vitoria, España. Electronic address: anamaria.gonzalez-pintoarrillaga@osakidetza.eus.
authors.forename: Ana
authors.initials: A
authors.lastname: González-Pinto
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy*; D003863:Depression / Q000188:drug therapy*; D006801:Humans; D007262:Infusions, Intravenous; D007649:Ketamine / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D007649:Ketamine
keywords: Bipolar depression; Depresión bipolar; Efficacy; Eficacia; Ketamina; Ketamine