title: [Hemophilia B replacement therapy drugs].
abstract: Hemophilia B is an X chromosome linked hereditary hemorrhagic disease, which is caused by the lose function mutation of factor IX (FIX), and significantly affects the patients' lifespan and life quality. The severity of hemophilia B depends on the FIX level in the plasma. By referring to the relevant literatures, we reviewed and summarized hemophilia B replacement therapies. Specifically, we focus on recombinant factor IX products on the market and those in the pipeline, especially on the long-acting factor IX drugs, to provide the basis for researches of new hemophilia B drugs.
authors.forename: Hong
authors.initials: H
authors.lastname: Yan
authors.forename: Fanyi
authors.initials: F
authors.lastname: Zeng
mesh_terms: D005164:Factor IX / Q000235:genetics / Q000627:therapeutic use*; D002836:Hemophilia B / Q000188:drug therapy*; D006801:Humans; D009154:Mutation; D011994:Recombinant Proteins / Q000627:therapeutic use*
chemical_list: D011994:Recombinant Proteins; D005164:Factor IX