title: Persistent Structural Plasticity Optimizes Sensory Information Processing in the Olfactory Bulb.
abstract: In the mammalian brain, the anatomical structure of neural circuits changes little during adulthood. As a result, adult learning and memory are thought to result from specific changes in synaptic strength. A possible exception is the olfactory bulb (OB), where activity guides interneuron turnover throughout adulthood. These adult-born granule cell (GC) interneurons form new GABAergic synapses that have little synaptic strength plasticity. In the face of persistent neuronal and synaptic turnover, how does the OB balance flexibility, as is required for adapting to changing sensory environments, with perceptual stability? Here we show that high dendritic spine turnover is a universal feature of GCs, regardless of their developmental origin and age. We find matching dynamics among postsynaptic sites on the principal neurons receiving the new synaptic inputs. We further demonstrate in silico that this coordinated structural plasticity is consistent with stable, yet flexible, decorrelated sensory representations. Together, our study reveals that persistent, coordinated synaptic structural plasticity between interneurons and principal neurons is a major mode of functional plasticity in the OB.
authors.affiliation: Laboratory for Perception and Memory, Pasteur Institute, 75015 Paris, France; Centre National de la Recherche Scientifique (CNRS), Unité de Recherche Associée (UMR3571), 75015 Paris, France; Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA; The Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, 725 N. Wolf Street, Baltimore, MD 21205, USA; Diana Helis Henry Medical Research Foundation, New Orleans, LA 70130-2685, USA.
authors.forename: Kurt A
authors.initials: KA
authors.lastname: Sailor
authors.affiliation: Laboratory for Perception and Memory, Pasteur Institute, 75015 Paris, France; Centre National de la Recherche Scientifique (CNRS), Unité de Recherche Associée (UMR3571), 75015 Paris, France.
authors.forename: Matthew T
authors.initials: MT
authors.lastname: Valley
authors.affiliation: Laboratory for Perception and Memory, Pasteur Institute, 75015 Paris, France; Centre National de la Recherche Scientifique (CNRS), Unité de Recherche Associée (UMR3571), 75015 Paris, France.
authors.forename: Martin T
authors.initials: MT
authors.lastname: Wiechert
authors.affiliation: Engineering Science and Applied Mathematics, Northwestern University, Evanston, IL 60208, USA.
authors.forename: Hermann
authors.initials: H
authors.lastname: Riecke
authors.affiliation: Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA; The Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, 725 N. Wolf Street, Baltimore, MD 21205, USA.
authors.forename: Gerald J
authors.initials: GJ
authors.lastname: Sun
authors.affiliation: Engineering Science and Applied Mathematics, Northwestern University, Evanston, IL 60208, USA.
authors.forename: Wayne
authors.initials: W
authors.lastname: Adams
authors.affiliation: Engineering Science and Applied Mathematics, Northwestern University, Evanston, IL 60208, USA.
authors.forename: James C
authors.initials: JC
authors.lastname: Dennis
authors.affiliation: Laboratory for Perception and Memory, Pasteur Institute, 75015 Paris, France; Centre National de la Recherche Scientifique (CNRS), Unité de Recherche Associée (UMR3571), 75015 Paris, France.
authors.forename: Shirin
authors.initials: S
authors.lastname: Sharafi
authors.affiliation: Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA; The Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, 725 N. Wolf Street, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, 600 N. Wolf Street, Baltimore, MD 21205, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Diana Helis Henry Medical Research Foundation, New Orleans, LA 70130-2685, USA.
authors.forename: Guo-Li
authors.initials: GL
authors.lastname: Ming
authors.affiliation: Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA; The Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, 725 N. Wolf Street, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, 600 N. Wolf Street, Baltimore, MD 21205, USA; Diana Helis Henry Medical Research Foundation, New Orleans, LA 70130-2685, USA. Electronic address: shongju1@jhmi.edu.
authors.forename: Hongjun
authors.initials: H
authors.lastname: Song
authors.affiliation: Laboratory for Perception and Memory, Pasteur Institute, 75015 Paris, France; Centre National de la Recherche Scientifique (CNRS), Unité de Recherche Associée (UMR3571), 75015 Paris, France. Electronic address: pierre-marie.lledo@pasteur.fr.
authors.forename: Pierre-Marie
authors.initials: PM
authors.lastname: Lledo
mesh_terms: D000818:Animals; D049229:Dendritic Spines / Q000378:metabolism; D007395:Interneurons / Q000502:physiology*; D051379:Mice; D009415:Nerve Net / Q000378:metabolism*; D055495:Neurogenesis / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology*; D009830:Olfactory Bulb / Q000502:physiology*; D018408:Patch-Clamp Techniques; D013569:Synapses / Q000378:metabolism*