title: Gray matter volume and dual-task gait performance in mild cognitive impairment.
abstract: Dual-task gait performance is impaired in older adults with mild cognitive impairment, but the brain substrates associated with dual-task gait performance are not well-established. The relationship between gray matter and gait speed under single-task and dual-task conditions (walking while counting backward) was examined in 560 seniors with mild cognitive impairment (non-amnestic mild cognitive impairment: n = 270; mean age = 72.4 yrs., 63.6 % women; amnestic mild cognitive impairment: n = 290; mean age = 73.4 yrs., 45.4 % women). Multivariate covariance-based analyses of magnetic resonance imaging data, adjusted for potential confounders including single-task gait speed, were performed to identify gray matter patterns associated with dual-task gait speed. There were no differences in gait speed or cognitive performance during dual-task gait between individuals with non-amnestic mild cognitive impairment and amnestic mild cognitive impairment. Overall, increased dual-task gait speed was associated with a gray matter pattern of increased volume in medial frontal gyrus, superior frontal gyrus, anterior cingulate, cingulate, precuneus, fusiform gyrus, middle occipital gyrus, inferior temporal gyrus and middle temporal gyrus. The relationship between dual-task gait speed and brain substrates also differed by mild cognitive impairment subtype. Our study revealed a pattern of gray matter regions associated with dual-task performance. Although dual-task gait performance was similar in amnestic and non-amnestic mild cognitive impairment, the gray matter patterns associated with dual-task gait performance differed by mild cognitive impairment subtype. These findings suggest that the brain substrates supporting dual-task gait performance in amnestic and non-amnestic subtypes are different, and consequently may respond differently to interventions, or require different interventions.
authors.affiliation: Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu, Aichi, Japan. take-d@ncgg.go.jp.|Japan Society for the Promotion of Science, Chiyoda-ku, Tokyo, Japan. take-d@ncgg.go.jp.|Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, USA. take-d@ncgg.go.jp.|Department of Medicine, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, USA. take-d@ncgg.go.jp.
authors.forename: Takehiko
authors.initials: T
authors.lastname: Doi
authors.affiliation: Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, USA.|Department of Medicine, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, USA.
authors.forename: Helena M
authors.initials: HM
authors.lastname: Blumen
authors.affiliation: Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, USA.|Department of Medicine, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, USA.
authors.forename: Joe
authors.initials: J
authors.lastname: Verghese
authors.affiliation: Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu, Aichi, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Shimada
authors.affiliation: Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu, Aichi, Japan.
authors.forename: Hyuma
authors.initials: H
authors.lastname: Makizako
authors.affiliation: Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu, Aichi, Japan.
authors.forename: Kota
authors.initials: K
authors.lastname: Tsutsumimoto
authors.affiliation: Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu, Aichi, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Hotta
authors.affiliation: Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu, Aichi, Japan.
authors.forename: Sho
authors.initials: S
authors.lastname: Nakakubo
authors.affiliation: National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu, Aichi, 474-8511, Japan.|Graduate School of Gerontology, J.F. Oberlin University, Machida, Tokyo, Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Suzuki
mesh_terms: D000368:Aged; D001696:Biomechanical Phenomena; D060825:Cognitive Dysfunction / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D003704:Dementia / Q000000981:diagnostic imaging / Q000503:physiopathology; D005260:Female; D005684:Gait / Q000502:physiology; D066128:Gray Matter / Q000000981:diagnostic imaging*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D015999:Multivariate Analysis; D009929:Organ Size
keywords: Brain atrophy; Dementia; MCI; Mobility