title: The risk factors of colistin methanesulfonate associated nephrotoxicity.
abstract: OBJECTIVE
  The risk factors of colistin methanesulfonate (CMS) associated nephrotoxicity are important. Our study attempts look into the prevalence of CMS-associated nephrotoxicity in Intensive Care Units (ICUs), and related risk factors.
  
  
  METHODS
  The study was conducted between September 2010 and April 2012 on 55 patients who underwent CMS treatment. Nephrotoxicity risk was defined based on the Risk Injury Failure Loss End-stage kidney disease criteria.
  
  
  RESULTS
  Fifty-five patients included in the study. A total of 22 (40%) patients developed nephrotoxicity. The correlation was detected between nephrotoxicity and patients over 65 with a high Acute Physiologic Assessment and Chronic Health Evaluation (APACHE) II score. APACHE II score was revealed an independent risk factor for nephrotoxicity.
  
  
  CONCLUSIONS
  Advanced age and a high APACHE II score are significant risk factors in the development of nephrotoxicity at ICUs following CMS use. Patient selection and close monitoring are critical when starting CMS treatment.
authors.affiliation: Department of Infectious Disease, School of Medicine, Marmara University, Istanbul, Turkey.
authors.forename: Elif Tükenmez
authors.initials: ET
authors.lastname: Tigen
authors.affiliation: Department of Anesthesiology, Istanbul Medeniyet University Göztepe Training and Research Hospital, Istanbul, Turkey.
authors.forename: E Nursen
authors.initials: EN
authors.lastname: Koltka
authors.affiliation: Department of Infectious Disease, Istanbul Medeniyet University Göztepe Training and Research Hospital, Istanbul, Turkey.
authors.forename: Arzu
authors.initials: A
authors.lastname: Dogru
authors.affiliation: Department of Anesthesiology, Istanbul Medeniyet University Göztepe Training and Research Hospital, Istanbul, Turkey.
authors.forename: Melek
authors.initials: M
authors.lastname: Gura
authors.affiliation: Department of Infectious Disease, Istanbul Medeniyet University Göztepe Training and Research Hospital, Istanbul, Turkey.
authors.forename: Haluk
authors.initials: H
authors.lastname: Vahabaoglu
keywords: Colistin methanesulfonate; nephrotoxicity; risk factors