title: A Case of Optic Neuritis Concomitant with Pituitary Tumor During Pregnancy.
abstract: BACKGROUND
  Optic neuritis (ON) is unilateral painful optic nerve inflammation in a young healthy female diagnosed by excluding glaucoma. ON onset during pregnancy is rare, with only 2 cases reported to date.
  
  
  METHODS
  A 35-year-old previously healthy parous woman who was pregnant with her second child suffered rapidly progressive visual acuity loss. Magnetic resonance imaging (MRI) revealed a pituitary tumor. Emergency surgery was performed for optic nerve compression; however, her visual impairment worsened. Postoperative diffusion-weighted MRI showed high intensity in the bilateral optic nerves, and ON was diagnosed. Administration of methylprednisolone was effective, and her visual acuity recovered over 6 months.
  
  
  CONCLUSIONS
  Associated pituitary macroadenoma complicated the true diagnosis of ON, because contrast medium cannot be used in pregnant women. The diffusion-weighted MRI findings were useful for diagnosing this complex clinical condition.
authors.affiliation: Department of Neurosurgery, General Fujioka Hospital, Fujioka, Gunma, Japan; Department of Neurosurgery, Japanese Red Cross Maebashi Hospital, Maebashi, Gunma, Japan. Electronic address: rei.yamaguchi@maebashi.jrc.or.jp.
authors.forename: Rei
authors.initials: R
authors.lastname: Yamaguchi
authors.affiliation: Department of Neurosurgery, General Fujioka Hospital, Fujioka, Gunma, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kohga
authors.affiliation: Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Tosaka
authors.affiliation: Department of Neurology, Japanese Red Cross Maebashi Hospital, Maebashi, Gunma, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Sekine
authors.affiliation: Department of Neurology, Japanese Red Cross Maebashi Hospital, Maebashi, Gunma, Japan.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Mizushima
authors.affiliation: Department of Neurology, Japanese Red Cross Maebashi Hospital, Maebashi, Gunma, Japan.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Harigaya
authors.affiliation: Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
authors.forename: Yuhei
authors.initials: Y
authors.lastname: Yoshimoto
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D005260:Female; D006801:Humans; D009408:Nerve Compression Syndromes / Q000000981:diagnostic imaging / Q000209:etiology* / Q000517:prevention & control*; D009902:Optic Neuritis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000517:prevention & control*; D010911:Pituitary Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000000981:diagnostic imaging / Q000628:therapy*; D016896:Treatment Outcome
keywords: Optic neuritis; Pituitary tumor; Pregnancy