title: The RAISE Connection Program: Psychopharmacological Treatment of People With a First Episode of Schizophrenia.
abstract: This study examined the adherence of psychiatrists to the Schedule of Recommended First and Second Line Antipsychotic Medications ("Antipsychotic Schedule"), which was implemented in two Recovery After an Initial Schizophrenia Episode (RAISE) Connection Program Implementation and Evaluation Study clinics.
  
  
  
  Sixty-five individuals with a first episode of psychosis were enrolled in the RAISE Connection Program clinics. Two psychiatrists received training and ongoing consultation on use of a shared decision-making approach to prescribing antipsychotic medications according to the Antipsychotic Schedule. Information about participants, prescribed antipsychotic medications, and completion of side-effect assessments were obtained from standardized research assessments and chart extractions. Descriptive statistics were used to characterize the extent to which patterns of antipsychotic prescribing and side-effect monitoring were consistent with the Antipsychotic Schedule.
  
  
  
  Ninety-two percent of participants were prescribed an antipsychotic medication and received the medication on 76%±35% of the days they were in treatment. Seventy-seven percent of participants were prescribed at least one Antipsychotic Schedule first-line antipsychotic, 20% were prescribed olanzapine, and 10% received a trial of clozapine. Regarding monitoring for metabolic side effects, 92% of participants had at least one weight recorded, 72% had at least one blood glucose measure recorded, and 62% had at least one lipid profile recorded.
  
  
  
  In the context of a study in which training and ongoing clinical supervision by experts was provided to psychiatrists and shared decision making was encouraged, antipsychotic prescribing patterns closely adhered to recommendations established by the RAISE Connection Program.
authors.affiliation: Dr. Kreyenbuhl, Dr. Medoff, and Dr. Hackman are with the Department of Psychiatry, University of Maryland School of Medicine, Baltimore (e-mail: jkreyenb@psych.umaryland.edu ). Dr. Kreyenbuhl and Dr. Medoff are also with the Mental Illness Research, Education and Clinical Center, Department of Veterans Affairs Capitol Healthcare Network (VISN 5), Baltimore. Dr. McEvoy is with the Department of Psychiatry, Medical College of Georgia, Augusta University, Augusta. Dr. Smith, Dr. Nossel, Dr. Dixon, and Dr. Essock are with the Department of Psychiatry, Columbia University College of Physicians and Surgeons, and with the New York State Psychiatric Institute, New York City. Dr. Buchanan is with the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore.
authors.forename: Julie A
authors.initials: JA
authors.lastname: Kreyenbuhl
authors.affiliation: Dr. Kreyenbuhl, Dr. Medoff, and Dr. Hackman are with the Department of Psychiatry, University of Maryland School of Medicine, Baltimore (e-mail: jkreyenb@psych.umaryland.edu ). Dr. Kreyenbuhl and Dr. Medoff are also with the Mental Illness Research, Education and Clinical Center, Department of Veterans Affairs Capitol Healthcare Network (VISN 5), Baltimore. Dr. McEvoy is with the Department of Psychiatry, Medical College of Georgia, Augusta University, Augusta. Dr. Smith, Dr. Nossel, Dr. Dixon, and Dr. Essock are with the Department of Psychiatry, Columbia University College of Physicians and Surgeons, and with the New York State Psychiatric Institute, New York City. Dr. Buchanan is with the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore.
authors.forename: Deborah R
authors.initials: DR
authors.lastname: Medoff
authors.affiliation: Dr. Kreyenbuhl, Dr. Medoff, and Dr. Hackman are with the Department of Psychiatry, University of Maryland School of Medicine, Baltimore (e-mail: jkreyenb@psych.umaryland.edu ). Dr. Kreyenbuhl and Dr. Medoff are also with the Mental Illness Research, Education and Clinical Center, Department of Veterans Affairs Capitol Healthcare Network (VISN 5), Baltimore. Dr. McEvoy is with the Department of Psychiatry, Medical College of Georgia, Augusta University, Augusta. Dr. Smith, Dr. Nossel, Dr. Dixon, and Dr. Essock are with the Department of Psychiatry, Columbia University College of Physicians and Surgeons, and with the New York State Psychiatric Institute, New York City. Dr. Buchanan is with the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore.
authors.forename: Joseph P
authors.initials: JP
authors.lastname: McEvoy
authors.affiliation: Dr. Kreyenbuhl, Dr. Medoff, and Dr. Hackman are with the Department of Psychiatry, University of Maryland School of Medicine, Baltimore (e-mail: jkreyenb@psych.umaryland.edu ). Dr. Kreyenbuhl and Dr. Medoff are also with the Mental Illness Research, Education and Clinical Center, Department of Veterans Affairs Capitol Healthcare Network (VISN 5), Baltimore. Dr. McEvoy is with the Department of Psychiatry, Medical College of Georgia, Augusta University, Augusta. Dr. Smith, Dr. Nossel, Dr. Dixon, and Dr. Essock are with the Department of Psychiatry, Columbia University College of Physicians and Surgeons, and with the New York State Psychiatric Institute, New York City. Dr. Buchanan is with the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore.
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Smith
authors.affiliation: Dr. Kreyenbuhl, Dr. Medoff, and Dr. Hackman are with the Department of Psychiatry, University of Maryland School of Medicine, Baltimore (e-mail: jkreyenb@psych.umaryland.edu ). Dr. Kreyenbuhl and Dr. Medoff are also with the Mental Illness Research, Education and Clinical Center, Department of Veterans Affairs Capitol Healthcare Network (VISN 5), Baltimore. Dr. McEvoy is with the Department of Psychiatry, Medical College of Georgia, Augusta University, Augusta. Dr. Smith, Dr. Nossel, Dr. Dixon, and Dr. Essock are with the Department of Psychiatry, Columbia University College of Physicians and Surgeons, and with the New York State Psychiatric Institute, New York City. Dr. Buchanan is with the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore.
authors.forename: Ann L
authors.initials: AL
authors.lastname: Hackman
authors.affiliation: Dr. Kreyenbuhl, Dr. Medoff, and Dr. Hackman are with the Department of Psychiatry, University of Maryland School of Medicine, Baltimore (e-mail: jkreyenb@psych.umaryland.edu ). Dr. Kreyenbuhl and Dr. Medoff are also with the Mental Illness Research, Education and Clinical Center, Department of Veterans Affairs Capitol Healthcare Network (VISN 5), Baltimore. Dr. McEvoy is with the Department of Psychiatry, Medical College of Georgia, Augusta University, Augusta. Dr. Smith, Dr. Nossel, Dr. Dixon, and Dr. Essock are with the Department of Psychiatry, Columbia University College of Physicians and Surgeons, and with the New York State Psychiatric Institute, New York City. Dr. Buchanan is with the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore.
authors.forename: Ilana R
authors.initials: IR
authors.lastname: Nossel
authors.affiliation: Dr. Kreyenbuhl, Dr. Medoff, and Dr. Hackman are with the Department of Psychiatry, University of Maryland School of Medicine, Baltimore (e-mail: jkreyenb@psych.umaryland.edu ). Dr. Kreyenbuhl and Dr. Medoff are also with the Mental Illness Research, Education and Clinical Center, Department of Veterans Affairs Capitol Healthcare Network (VISN 5), Baltimore. Dr. McEvoy is with the Department of Psychiatry, Medical College of Georgia, Augusta University, Augusta. Dr. Smith, Dr. Nossel, Dr. Dixon, and Dr. Essock are with the Department of Psychiatry, Columbia University College of Physicians and Surgeons, and with the New York State Psychiatric Institute, New York City. Dr. Buchanan is with the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore.
authors.forename: Lisa B
authors.initials: LB
authors.lastname: Dixon
authors.affiliation: Dr. Kreyenbuhl, Dr. Medoff, and Dr. Hackman are with the Department of Psychiatry, University of Maryland School of Medicine, Baltimore (e-mail: jkreyenb@psych.umaryland.edu ). Dr. Kreyenbuhl and Dr. Medoff are also with the Mental Illness Research, Education and Clinical Center, Department of Veterans Affairs Capitol Healthcare Network (VISN 5), Baltimore. Dr. McEvoy is with the Department of Psychiatry, Medical College of Georgia, Augusta University, Augusta. Dr. Smith, Dr. Nossel, Dr. Dixon, and Dr. Essock are with the Department of Psychiatry, Columbia University College of Physicians and Surgeons, and with the New York State Psychiatric Institute, New York City. Dr. Buchanan is with the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore.
authors.forename: Susan M
authors.initials: SM
authors.lastname: Essock
authors.affiliation: Dr. Kreyenbuhl, Dr. Medoff, and Dr. Hackman are with the Department of Psychiatry, University of Maryland School of Medicine, Baltimore (e-mail: jkreyenb@psych.umaryland.edu ). Dr. Kreyenbuhl and Dr. Medoff are also with the Mental Illness Research, Education and Clinical Center, Department of Veterans Affairs Capitol Healthcare Network (VISN 5), Baltimore. Dr. McEvoy is with the Department of Psychiatry, Medical College of Georgia, Augusta University, Augusta. Dr. Smith, Dr. Nossel, Dr. Dixon, and Dr. Essock are with the Department of Psychiatry, Columbia University College of Physicians and Surgeons, and with the New York State Psychiatric Institute, New York City. Dr. Buchanan is with the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore.
authors.forename: Robert W
authors.initials: RW
authors.lastname: Buchanan
mesh_terms: D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001569:Benzodiazepines / Q000008:administration & dosage; D003024:Clozapine / Q000008:administration & dosage; D003657:Decision Making; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D000077152:Olanzapine; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data*; D012559:Schizophrenia / Q000188:drug therapy*; D014481:United States; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D003024:Clozapine; D000077152:Olanzapine