title: Effect of Intravenous Mannitol on Intraocular Pressure in Vitrectomized Silicone-Oil-Filled Eyes.
abstract: OBJECTIVE
  To evaluate the effect of intravenous mannitol (IVM) on intraocular pressure (IOP) in vitrectomized eyes.
  
  
  METHODS
  Thirty-one patients with raised IOP after retinal surgery with silicone oil injection were included. Patients were administered IVM (20% solution, 1g/Kg, over 30 minutes) and IOP was noted at regular intervals. IOP reduction in vitrectomized eyes (Group 1) was compared with the normal eyes (Group 2).
  
  
  RESULTS
  Percentage IOP reduction was higher in Group 1 than in Group 2 at all time intervals, 24.5% vs. 19.2% at 15 minutes (p=0.34), 22.6% vs. 9.8% at 45 minutes (p=0.003), 19.1% vs. 9.9% at two hours (p=0.023), and 16.1% vs. 7.8% at four hours (p=0.04), respectively. In Group 1, 40% eyes had an IOP reduction of 2-6 mmHg while 30% eyes had IOP reduction >6 mmHg at four hours post-IVM.
  
  
  CONCLUSIONS
  IVM is useful for short-term IOP reduction in vitrectomized eyes. IOP reduction is independent of baseline IOP, and sustained and higher as compared to normal eyes.
authors.affiliation: a Dr. Rajendra Prasad Centre for Ophthalmic Sciences , AIIMS , New Delhi , India.
authors.forename: Brijesh
authors.initials: B
authors.lastname: Takkar
authors.affiliation: a Dr. Rajendra Prasad Centre for Ophthalmic Sciences , AIIMS , New Delhi , India.
authors.forename: Parijat
authors.initials: P
authors.lastname: Chandra
authors.affiliation: a Dr. Rajendra Prasad Centre for Ophthalmic Sciences , AIIMS , New Delhi , India.
authors.forename: Ritu
authors.initials: R
authors.lastname: Shah
authors.affiliation: a Dr. Rajendra Prasad Centre for Ophthalmic Sciences , AIIMS , New Delhi , India.
authors.forename: Indrish
authors.initials: I
authors.lastname: Bhatia
authors.affiliation: a Dr. Rajendra Prasad Centre for Ophthalmic Sciences , AIIMS , New Delhi , India.
authors.forename: Sangeeta
authors.initials: S
authors.lastname: Roy
authors.affiliation: a Dr. Rajendra Prasad Centre for Ophthalmic Sciences , AIIMS , New Delhi , India.
authors.forename: Ramanjit
authors.initials: R
authors.lastname: Sihota
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008353:Mannitol / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008875:Middle Aged; D009798:Ocular Hypertension / Q000188:drug therapy* / Q000209:etiology; D012827:Silicone Oils / Q000009:adverse effects; D014065:Tonometry, Ocular; D014821:Vitrectomy / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D012827:Silicone Oils; D008353:Mannitol
keywords: Glaucoma; glaucoma in vitrectomized eyes; mannitol; post vitreo-retinal surgery glaucoma; vitreous surgery