title: Differences in Metabolite Concentrations Between the Hemispheres of the Brain in Healthy Children: A Proton Magnetic Resonance Spectroscopy Study (1HMRS).
abstract: The aim of this (1)HMRS study was to identify hemispheric asymmetries in metabolismus in healthy children. The study group consisted of children of both sexes aged 6 to 15. Concentrations of 6 metabolites occurring in the brain were determined for 6 locations: hippocampus, frontal lobe, and basal ganglia in the left and right hemispheres. There were no hemispheric differences in the metabolites' concentrations in the brain in children when the variable of sex was disregarded. Only in the group of boys and in the group of girls did the findings show few discrepancies. In none of these groups, relative concentrations to creatine concentration were found to be significantly different between hemispheres. In clinical practice, concentrations of specific metabolites are most frequently determined relative to the concentration of creatine. Consequently, the analysis of standard (1)HMRS examinations in children does not need to take into account interhemispheric differences.
authors.affiliation: Department of Radiology, Collegium Medicum, Jagiellonian University, Krakow, Poland monika.cichocka@uj.edu.pl.
authors.forename: Monika
authors.initials: M
authors.lastname: Cichocka
authors.affiliation: Department of Radiology, Collegium Medicum, Jagiellonian University, Krakow, Poland.
authors.forename: Justyna
authors.initials: J
authors.lastname: Kozub
authors.affiliation: Department of Electroradiology, Collegium Medicum, Jagiellonian University, Krakow, Poland.
authors.forename: Paulina
authors.initials: P
authors.lastname: Karcz
authors.affiliation: Department of Radiology, Collegium Medicum, Jagiellonian University, Krakow, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Urbanik
mesh_terms: D000293:Adolescent; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001921:Brain / Q000000981:diagnostic imaging / Q000254:growth & development* / Q000378:metabolism*; D002648:Child; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007294:Inositol / Q000378:metabolism; D019344:Lactic Acid / Q000378:metabolism; D050356:Lipid Metabolism; D008297:Male; D066244:Proton Magnetic Resonance Spectroscopy; D012727:Sex Characteristics
chemical_list: D001224:Aspartic Acid; D019344:Lactic Acid; D007294:Inositol; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline
keywords: 1HMRS; brain; children; hemispheric differences; proton magnetic resonance spectroscopy