title: Vascular endothelial growth factor polymorphism (-460 T/C) is related to hypertension-associated chronic kidney disease.
abstract: Our aim was to characterize the endothelial progenitor cells (EPCs) in normotensive controls and treated hypertensive individuals within the vascular endothelial growth factor (VEGF) -460 C/T polymorphism as well as to investigate whether this polymorphism predisposes to hypertension-related chronic kidney disease. The hypertensive patients bearing the TT genotype had the highest levels of immature EPC with the following phenotypes: CD34(+), CD34(+)CD45(dim), CD34(+)CD133(+)CD45(dim). The study showed the estimated glomerular filtration rate values significantly lower and creatinine and BUN parameters higher among the TT hypertensive patients. We presume that the highest mobilization of EPCs from bone marrow may signalize more severe renal hypertension-related complications in the VEGF -460 TT genotype.
authors.affiliation: a Department of Immunology , Medical University of Gdańsk , Gdańsk , Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Małkiewicz
authors.affiliation: a Department of Immunology , Medical University of Gdańsk , Gdańsk , Poland.
authors.forename: Jolanta
authors.initials: J
authors.lastname: Myśliwska
authors.affiliation: a Department of Immunology , Medical University of Gdańsk , Gdańsk , Poland.
authors.forename: Maria
authors.initials: M
authors.lastname: Skrzypkowska
authors.affiliation: a Department of Immunology , Medical University of Gdańsk , Gdańsk , Poland.
authors.forename: Bartosz
authors.initials: B
authors.lastname: Słomiński
authors.affiliation: b Department of Family Medicine , Medical University of Gdańsk , Gdańsk , Poland.
authors.forename: Janusz
authors.initials: J
authors.lastname: Siebert
authors.affiliation: b Department of Family Medicine , Medical University of Gdańsk , Gdańsk , Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Gutknecht
mesh_terms: D000071916:AC133 Antigen / Q000235:genetics; D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000235:genetics; D001854:Bone Marrow Cells / Q000502:physiology; D002465:Cell Movement; D066026:Endothelial Progenitor Cells / Q000502:physiology*; D005260:Female; D005434:Flow Cytometry; D005838:Genotype; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D006977:Hypertension, Renal / Q000235:genetics* / Q000378:metabolism; D017493:Leukocyte Common Antigens / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D051436:Renal Insufficiency, Chronic / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics* / Q000378:metabolism; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000235:genetics
chemical_list: D000071916:AC133 Antigen; D018952:Antigens, CD34; D042461:Vascular Endothelial Growth Factor A; D040301:Vascular Endothelial Growth Factor Receptor-2; D017493:Leukocyte Common Antigens; C516769:PTPRC protein, human
keywords: Endothelial precursors; VEGF polymorphism; kidney disease