title: Two SNAP-25 genetic variants in the binding site of multiple microRNAs and susceptibility of ADHD: A meta-analysis.
abstract: The aim of this meta-analysis is to assess the associations between two most widely investigated polymorphisms (rs3746544 and rs1051312) in the 3'UTR of the SNAP-25 gene and susceptibility of ADHD. Two investigators selected related studies and assessed methodological quality independently. Six studies were included in this meta-analysis for a total of 715 cases and 655 controls. There is no apparent association between rs3746544 polymorphisms and risk of ADHD. However, subgroup analysis based on ethnicity demonstrated a strong association between rs3746544 polymorphism and ADHD in the subset of Asian participants, but not among Caucasians. Compared to the T allele, the allele G was associated with a significantly decreased risk of developing ADHD in the Asian population (odds ratio (OR) = 0.70, 95% confidence interval (CI) = 0.52-0.95, p = 0.02). The association between the TT genotype and ADHD risk was also significantly increased as compared to G/T (OR = 1.56, 95% CI = 1.00-2.44, p = 0.05) and the dominant genetic model (GG + GT vs. TT: OR = 1.51, 95% CI = 1.07-2.13, p = 0.02). For the rs1051312 SNP, being homozygous for the minor allele (C/C) was associated with a 3.66 higher odds of ADHD as compared to cases homozygous for the major allele (T/T) (95% CI = 1.64-8.13, p = 0.001), and 3.57 higher odds as compared to heterozygous (C/T) carriers (95% CI = 2.01-12.90, p < 0.001). Our results suggest that the polymorphisms rs3746544 and rs1051312 may increase the odds of developing ADHD. Additional studies are needed to confirm these findings.
authors.affiliation: Department of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine/Jackson Health System, 1695 NW 9th Ave, 33136, United States. Electronic address: Chuanzhong.ye@jhsmiami.org.
authors.forename: Chuanzhong
authors.initials: C
authors.lastname: Ye
authors.affiliation: Department of Epidemiology and Health Statistics, Fujian Medical University, 1 Xue Yuan Road University Town, Fujian, 350108, China.
authors.forename: Zhijian
authors.initials: Z
authors.lastname: Hu
authors.affiliation: Department of Health Sciences, University of Miami Miller School of Medicine, 1120 NW 14th St, Miami, FL, 33136, United States.
authors.forename: Evan
authors.initials: E
authors.lastname: Wu
authors.affiliation: Department of Epidemiology and Health Statistics, Fujian Medical University, 1 Xue Yuan Road University Town, Fujian, 350108, China.
authors.forename: Xiaolu
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine/Jackson Health System, 1695 NW 9th Ave, 33136, United States.
authors.forename: Ushimbra J
authors.initials: UJ
authors.lastname: Buford
authors.affiliation: Department of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine/Jackson Health System, 1695 NW 9th Ave, 33136, United States.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Guo
authors.affiliation: Department of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine/Jackson Health System, 1695 NW 9th Ave, 33136, United States.
authors.forename: Radu V
authors.initials: RV
authors.lastname: Saveanu
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics*; D001665:Binding Sites / Q000235:genetics; D016206:Databases, Bibliographic / Q000706:statistics & numerical data; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D050825:Synaptosomal-Associated Protein 25 / Q000235:genetics*
chemical_list: D035683:MicroRNAs; C494208:SNAP25 protein, human; D050825:Synaptosomal-Associated Protein 25
keywords: ADHD; SNP; microRNAs; rs1051312; rs3746544