title: Negative results in phase III trials of complex interventions: cause for concern or just good science?
abstract: Not all interventions that show promise in exploratory trials will be supported in phase III studies. But the high failure rate in recent trials of complex mental health interventions is a concern. Proper consideration of trial processes and greater use of adaptive trial designs could ensure better use of available resources.
authors.affiliation: Mike J. Crawford, FRCPsych, Kirsten Barnicot, PhD, Centre for Mental Health, Imperial College, London, UK; Sue Patterson, PhD, Metro North Mental Health, Queensland, Australia; Christian Gold, PhD, GAMUT, The Grieg Academy Music Therapy Research Centre, Uni Research Health, Bergen, Norway m.crawford@imperial.ac.uk.
authors.forename: Mike J
authors.initials: MJ
authors.lastname: Crawford
authors.affiliation: Mike J. Crawford, FRCPsych, Kirsten Barnicot, PhD, Centre for Mental Health, Imperial College, London, UK; Sue Patterson, PhD, Metro North Mental Health, Queensland, Australia; Christian Gold, PhD, GAMUT, The Grieg Academy Music Therapy Research Centre, Uni Research Health, Bergen, Norway.
authors.forename: Kirsten
authors.initials: K
authors.lastname: Barnicot
authors.affiliation: Mike J. Crawford, FRCPsych, Kirsten Barnicot, PhD, Centre for Mental Health, Imperial College, London, UK; Sue Patterson, PhD, Metro North Mental Health, Queensland, Australia; Christian Gold, PhD, GAMUT, The Grieg Academy Music Therapy Research Centre, Uni Research Health, Bergen, Norway.
authors.forename: Sue
authors.initials: S
authors.lastname: Patterson
authors.affiliation: Mike J. Crawford, FRCPsych, Kirsten Barnicot, PhD, Centre for Mental Health, Imperial College, London, UK; Sue Patterson, PhD, Metro North Mental Health, Queensland, Australia; Christian Gold, PhD, GAMUT, The Grieg Academy Music Therapy Research Centre, Uni Research Health, Bergen, Norway.
authors.forename: Christian
authors.initials: C
authors.lastname: Gold
mesh_terms: D017326:Clinical Trials, Phase III as Topic / Q000592:standards*; D006801:Humans