title: MLF1IP is correlated with progression and prognosis in luminal breast cancer.
abstract: Myeloid leukemia factor 1-interacting protein (MLF1IP) has been found to be involved in the progression of several malignancies. The potential correlation between MLF1IP and clinical outcome in patients with luminal breast cancer, however, remains unknown. In the present study, we demonstrated that MLF1IP was significantly upregulated in luminal breast cancer tissue compared with adjacent normal tissue both in validated cohort and TCGA cohort. Upregulated expression of MLF1IP was correlated with more often lymph node metastasis and negative progesterone receptor expression in TCGA cohorts. Kaplan-Meier analysis indicated that patients with high MLF1IP expression had significantly lower overall survival. Moreover, multivariate analysis revealed that high MLF1IP expression was independent high risk factor as well as old age (>60) and distant metastasis. This study provides new insights and evidences that MLF1IP over-expression plays important roles in progression of luminal breast cancer. However, the precise cellular mechanisms for MLF1IP in luminal breast cancer need to be further explored.
authors.affiliation: Cancer Center, TCM-Integrated Hospital of Southern Medical University, Guangzhou, Guangdong, PR China. Electronic address: oncology2004@163.com.
authors.forename: Du-Ping
authors.initials: DP
authors.lastname: Huang
authors.affiliation: Cancer Center, TCM-Integrated Hospital of Southern Medical University, Guangzhou, Guangdong, PR China. Electronic address: oncology201716@163.com.
authors.forename: Rong-Cheng
authors.initials: RC
authors.lastname: Luo
mesh_terms: D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology; D018797:Cell Cycle Proteins; D002681:China / Q000453:epidemiology; D018450:Disease Progression; D005260:Female; D006657:Histones; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009687:Nuclear Proteins / Q000378:metabolism*; D015995:Prevalence; D011379:Prognosis; D015203:Reproducibility of Results; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; C485917:CENPU protein, human; D018797:Cell Cycle Proteins; D006657:Histones; D009687:Nuclear Proteins
keywords: Luminal breast cancer; MLF1IP; Prognosis