title: Common and Rare Ocular Side-effects of the Dexamethasone Implant.
abstract: OBJECTIVE
  Expanding indications for use, and overall increased use of the slow-release dexamethasone (DEX) implant yields an opportunity to study the reported ocular side-effects and adverse events associated with this drug.
  
  
  METHODS
  A PubMed.gov (US National Library of Medicine, National Institutes of Health) review of literature for the search terms, "Ozurdex and complication," through December 2015.
  
  
  RESULTS
  Ocular hypertension and cataract are the main long-term sequelae identified in large, randomized clinical trials. Case reports have emerged regarding implant migration, complications with implantation, infection, and posterior segment sequelae, including vitreomacular traction.
  
  
  CONCLUSIONS
  DEX implant overall is well-tolerated and, with careful monitoring, can be a useful adjunct to treating macular edema associated with diabetes, retinal vein occlusion, and chronic uveitis.
authors.affiliation: a Department of Ophthalmology and Visual Sciences , University of Louisville School of Medicine, University of Louisville , Louisville , Kentucky , USA.
authors.forename: Janelle M
authors.identifier: http://orcid.org/0000-0001-5125-544X
authors.initials: JM
authors.lastname: Fassbender Adeniran
authors.affiliation: a Department of Ophthalmology and Visual Sciences , University of Louisville School of Medicine, University of Louisville , Louisville , Kentucky , USA.
authors.forename: Denis
authors.initials: D
authors.lastname: Jusufbegovic
authors.affiliation: b Department of Ophthalmology and Visual Sciences , University of Massachusetts School of Medicine , Worcester , Massachusetts , USA.
authors.forename: Shlomit
authors.initials: S
authors.lastname: Schaal
mesh_terms: D002386:Cataract / Q000139:chemically induced; D016208:Databases, Factual; D003907:Dexamethasone / Q000008:administration & dosage / Q000009:adverse effects*; D004343:Drug Implants; D064420:Drug-Related Side Effects and Adverse Reactions / Q000209:etiology*; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D058449:Intravitreal Injections; D008269:Macular Edema / Q000188:drug therapy; D009798:Ocular Hypertension / Q000139:chemically induced; D012170:Retinal Vein Occlusion / Q000188:drug therapy
chemical_list: D004343:Drug Implants; D005938:Glucocorticoids; D003907:Dexamethasone
keywords: Cystoid macular edema; Ozurdex®; dexamethasone; retinal vein occlusion; side-effects; uveitis