title: Cathepsin S Activity Controls Injury-Related Vascular Repair in Mice via the TLR2-Mediated p38MAPK and PI3K-Akt/p-HDAC6 Signaling Pathway.
abstract: Cathepsin S (CatS) participates in atherogenesis through several putative mechanisms. The ability of cathepsins to modify histone tail is likely to contribute to stem cell development. Histone deacetylase 6 (HDAC6) is required in modulating the proliferation and migration of various types of cancer cells. Here, we investigated the cross talk between CatS and HADC6 in injury-related vascular repair in mice.
  
  
  
  Ligation injury to the carotid artery in mice increased the CatS expression, and CatS-deficient mice showed reduced neointimal formation in injured arteries. CatS deficiency decreased the phosphorylation levels of p38 mitogen-activated protein kinase, Akt, and HDAC6 and toll-like receptor 2 expression in ligated arteries. The genetic or pharmacological inhibition of CatS also alleviated the increased phosphorylation of p38 mitogen-activated protein kinase, Akt, and HDAC6 induced by platelet-derived growth factor BB in cultured vascular smooth muscle cells (VSMCs), and p38 mitogen-activated protein kinase inhibition and Akt inhibition decreased the phospho-HDAC6 levels. Moreover, CatS inhibition caused decrease in the levels of the HDAC6 activity in VSMCs in response to platelet-derived growth factor BB. The HDAC6 inhibitor tubastatin A downregulated platelet-derived growth factor-induced VSMC proliferation and migration, whereas HDAC6 overexpression exerted the opposite effect. Tubastatin A also decreased the intimal VSMC proliferation and neointimal hyperplasia in response to injury. Toll-like receptor 2 silencing decreased the phosphorylation levels of p38 mitogen-activated protein kinase, Akt, and HDAC6 and VSMC migration and proliferation.
  
  
  
  This is the first report detailing cross-interaction between toll-like receptor 2-mediated CatS and HDAC6 during injury-related vascular repair. These data suggest that CatS/HDAC6 could be a potential therapeutic target for the control of vascular diseases that are involved in neointimal lesion formation.
authors.affiliation: From the Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (H.W., Q. Du, S.L., Q. Dai); Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan (H.W., X.W.C., K.T., M.Y., T.M.); Department of Pathology and Cell Biology, University of South Florida Morsani College of Medicine, Tampa, FL (C.H., X.Z.); Department of Cardiology, Yanbian University Hospital, Yanji, China (X.W.C., X.L., E.Z., G.Z., L.P., Y.L.); Department of and Community Healthcare & Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan (X.W.C., L.H., A.I., M.K.); Department of Neurology, University of Occupational and Environmental Health, Fukuoka, Japan (Z.H.); Department of Physiology and Pathophysiology, Yanbian University College of Medicine, Yanji, China (H.J.); Division of Cardiology, Department of Internal Medicine, Kyung Hee University, Seoul, South Korea (X.W.C); and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (G.P.S.).
authors.forename: Hongxian
authors.initials: H
authors.lastname: Wu
authors.affiliation: From the Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (H.W., Q. Du, S.L., Q. Dai); Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan (H.W., X.W.C., K.T., M.Y., T.M.); Department of Pathology and Cell Biology, University of South Florida Morsani College of Medicine, Tampa, FL (C.H., X.Z.); Department of Cardiology, Yanbian University Hospital, Yanji, China (X.W.C., X.L., E.Z., G.Z., L.P., Y.L.); Department of and Community Healthcare & Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan (X.W.C., L.H., A.I., M.K.); Department of Neurology, University of Occupational and Environmental Health, Fukuoka, Japan (Z.H.); Department of Physiology and Pathophysiology, Yanbian University College of Medicine, Yanji, China (H.J.); Division of Cardiology, Department of Internal Medicine, Kyung Hee University, Seoul, South Korea (X.W.C); and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (G.P.S.). chengxw0908@163.com 1583477ngu@gmail.com.
authors.forename: Xian Wu
authors.initials: XW
authors.lastname: Cheng
authors.affiliation: From the Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (H.W., Q. Du, S.L., Q. Dai); Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan (H.W., X.W.C., K.T., M.Y., T.M.); Department of Pathology and Cell Biology, University of South Florida Morsani College of Medicine, Tampa, FL (C.H., X.Z.); Department of Cardiology, Yanbian University Hospital, Yanji, China (X.W.C., X.L., E.Z., G.Z., L.P., Y.L.); Department of and Community Healthcare & Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan (X.W.C., L.H., A.I., M.K.); Department of Neurology, University of Occupational and Environmental Health, Fukuoka, Japan (Z.H.); Department of Physiology and Pathophysiology, Yanbian University College of Medicine, Yanji, China (H.J.); Division of Cardiology, Department of Internal Medicine, Kyung Hee University, Seoul, South Korea (X.W.C); and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (G.P.S.).
authors.forename: Lina
authors.initials: L
authors.lastname: Hu
authors.affiliation: From the Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (H.W., Q. Du, S.L., Q. Dai); Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan (H.W., X.W.C., K.T., M.Y., T.M.); Department of Pathology and Cell Biology, University of South Florida Morsani College of Medicine, Tampa, FL (C.H., X.Z.); Department of Cardiology, Yanbian University Hospital, Yanji, China (X.W.C., X.L., E.Z., G.Z., L.P., Y.L.); Department of and Community Healthcare & Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan (X.W.C., L.H., A.I., M.K.); Department of Neurology, University of Occupational and Environmental Health, Fukuoka, Japan (Z.H.); Department of Physiology and Pathophysiology, Yanbian University College of Medicine, Yanji, China (H.J.); Division of Cardiology, Department of Internal Medicine, Kyung Hee University, Seoul, South Korea (X.W.C); and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (G.P.S.).
authors.forename: Kyosuke
authors.initials: K
authors.lastname: Takeshita
authors.affiliation: From the Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (H.W., Q. Du, S.L., Q. Dai); Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan (H.W., X.W.C., K.T., M.Y., T.M.); Department of Pathology and Cell Biology, University of South Florida Morsani College of Medicine, Tampa, FL (C.H., X.Z.); Department of Cardiology, Yanbian University Hospital, Yanji, China (X.W.C., X.L., E.Z., G.Z., L.P., Y.L.); Department of and Community Healthcare & Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan (X.W.C., L.H., A.I., M.K.); Department of Neurology, University of Occupational and Environmental Health, Fukuoka, Japan (Z.H.); Department of Physiology and Pathophysiology, Yanbian University College of Medicine, Yanji, China (H.J.); Division of Cardiology, Department of Internal Medicine, Kyung Hee University, Seoul, South Korea (X.W.C); and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (G.P.S.).
authors.forename: Chen
authors.initials: C
authors.lastname: Hu
authors.affiliation: From the Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (H.W., Q. Du, S.L., Q. Dai); Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan (H.W., X.W.C., K.T., M.Y., T.M.); Department of Pathology and Cell Biology, University of South Florida Morsani College of Medicine, Tampa, FL (C.H., X.Z.); Department of Cardiology, Yanbian University Hospital, Yanji, China (X.W.C., X.L., E.Z., G.Z., L.P., Y.L.); Department of and Community Healthcare & Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan (X.W.C., L.H., A.I., M.K.); Department of Neurology, University of Occupational and Environmental Health, Fukuoka, Japan (Z.H.); Department of Physiology and Pathophysiology, Yanbian University College of Medicine, Yanji, China (H.J.); Division of Cardiology, Department of Internal Medicine, Kyung Hee University, Seoul, South Korea (X.W.C); and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (G.P.S.).
authors.forename: Qiuna
authors.initials: Q
authors.lastname: Du
authors.affiliation: From the Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (H.W., Q. Du, S.L., Q. Dai); Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan (H.W., X.W.C., K.T., M.Y., T.M.); Department of Pathology and Cell Biology, University of South Florida Morsani College of Medicine, Tampa, FL (C.H., X.Z.); Department of Cardiology, Yanbian University Hospital, Yanji, China (X.W.C., X.L., E.Z., G.Z., L.P., Y.L.); Department of and Community Healthcare & Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan (X.W.C., L.H., A.I., M.K.); Department of Neurology, University of Occupational and Environmental Health, Fukuoka, Japan (Z.H.); Department of Physiology and Pathophysiology, Yanbian University College of Medicine, Yanji, China (H.J.); Division of Cardiology, Department of Internal Medicine, Kyung Hee University, Seoul, South Korea (X.W.C); and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (G.P.S.).
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.affiliation: From the Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (H.W., Q. Du, S.L., Q. Dai); Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan (H.W., X.W.C., K.T., M.Y., T.M.); Department of Pathology and Cell Biology, University of South Florida Morsani College of Medicine, Tampa, FL (C.H., X.Z.); Department of Cardiology, Yanbian University Hospital, Yanji, China (X.W.C., X.L., E.Z., G.Z., L.P., Y.L.); Department of and Community Healthcare & Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan (X.W.C., L.H., A.I., M.K.); Department of Neurology, University of Occupational and Environmental Health, Fukuoka, Japan (Z.H.); Department of Physiology and Pathophysiology, Yanbian University College of Medicine, Yanji, China (H.J.); Division of Cardiology, Department of Internal Medicine, Kyung Hee University, Seoul, South Korea (X.W.C); and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (G.P.S.).
authors.forename: Enbo
authors.initials: E
authors.lastname: Zhu
authors.affiliation: From the Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (H.W., Q. Du, S.L., Q. Dai); Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan (H.W., X.W.C., K.T., M.Y., T.M.); Department of Pathology and Cell Biology, University of South Florida Morsani College of Medicine, Tampa, FL (C.H., X.Z.); Department of Cardiology, Yanbian University Hospital, Yanji, China (X.W.C., X.L., E.Z., G.Z., L.P., Y.L.); Department of and Community Healthcare & Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan (X.W.C., L.H., A.I., M.K.); Department of Neurology, University of Occupational and Environmental Health, Fukuoka, Japan (Z.H.); Department of Physiology and Pathophysiology, Yanbian University College of Medicine, Yanji, China (H.J.); Division of Cardiology, Department of Internal Medicine, Kyung Hee University, Seoul, South Korea (X.W.C); and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (G.P.S.).
authors.forename: Zhe
authors.initials: Z
authors.lastname: Huang
authors.affiliation: From the Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (H.W., Q. Du, S.L., Q. Dai); Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan (H.W., X.W.C., K.T., M.Y., T.M.); Department of Pathology and Cell Biology, University of South Florida Morsani College of Medicine, Tampa, FL (C.H., X.Z.); Department of Cardiology, Yanbian University Hospital, Yanji, China (X.W.C., X.L., E.Z., G.Z., L.P., Y.L.); Department of and Community Healthcare & Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan (X.W.C., L.H., A.I., M.K.); Department of Neurology, University of Occupational and Environmental Health, Fukuoka, Japan (Z.H.); Department of Physiology and Pathophysiology, Yanbian University College of Medicine, Yanji, China (H.J.); Division of Cardiology, Department of Internal Medicine, Kyung Hee University, Seoul, South Korea (X.W.C); and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (G.P.S.).
authors.forename: Maimaiti
authors.initials: M
authors.lastname: Yisireyili
authors.affiliation: From the Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (H.W., Q. Du, S.L., Q. Dai); Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan (H.W., X.W.C., K.T., M.Y., T.M.); Department of Pathology and Cell Biology, University of South Florida Morsani College of Medicine, Tampa, FL (C.H., X.Z.); Department of Cardiology, Yanbian University Hospital, Yanji, China (X.W.C., X.L., E.Z., G.Z., L.P., Y.L.); Department of and Community Healthcare & Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan (X.W.C., L.H., A.I., M.K.); Department of Neurology, University of Occupational and Environmental Health, Fukuoka, Japan (Z.H.); Department of Physiology and Pathophysiology, Yanbian University College of Medicine, Yanji, China (H.J.); Division of Cardiology, Department of Internal Medicine, Kyung Hee University, Seoul, South Korea (X.W.C); and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (G.P.S.).
authors.forename: Guangxian
authors.initials: G
authors.lastname: Zhao
authors.affiliation: From the Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (H.W., Q. Du, S.L., Q. Dai); Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan (H.W., X.W.C., K.T., M.Y., T.M.); Department of Pathology and Cell Biology, University of South Florida Morsani College of Medicine, Tampa, FL (C.H., X.Z.); Department of Cardiology, Yanbian University Hospital, Yanji, China (X.W.C., X.L., E.Z., G.Z., L.P., Y.L.); Department of and Community Healthcare & Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan (X.W.C., L.H., A.I., M.K.); Department of Neurology, University of Occupational and Environmental Health, Fukuoka, Japan (Z.H.); Department of Physiology and Pathophysiology, Yanbian University College of Medicine, Yanji, China (H.J.); Division of Cardiology, Department of Internal Medicine, Kyung Hee University, Seoul, South Korea (X.W.C); and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (G.P.S.).
authors.forename: Limei
authors.initials: L
authors.lastname: Piao
authors.affiliation: From the Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (H.W., Q. Du, S.L., Q. Dai); Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan (H.W., X.W.C., K.T., M.Y., T.M.); Department of Pathology and Cell Biology, University of South Florida Morsani College of Medicine, Tampa, FL (C.H., X.Z.); Department of Cardiology, Yanbian University Hospital, Yanji, China (X.W.C., X.L., E.Z., G.Z., L.P., Y.L.); Department of and Community Healthcare & Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan (X.W.C., L.H., A.I., M.K.); Department of Neurology, University of Occupational and Environmental Health, Fukuoka, Japan (Z.H.); Department of Physiology and Pathophysiology, Yanbian University College of Medicine, Yanji, China (H.J.); Division of Cardiology, Department of Internal Medicine, Kyung Hee University, Seoul, South Korea (X.W.C); and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (G.P.S.).
authors.forename: Aiko
authors.initials: A
authors.lastname: Inoue
authors.affiliation: From the Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (H.W., Q. Du, S.L., Q. Dai); Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan (H.W., X.W.C., K.T., M.Y., T.M.); Department of Pathology and Cell Biology, University of South Florida Morsani College of Medicine, Tampa, FL (C.H., X.Z.); Department of Cardiology, Yanbian University Hospital, Yanji, China (X.W.C., X.L., E.Z., G.Z., L.P., Y.L.); Department of and Community Healthcare & Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan (X.W.C., L.H., A.I., M.K.); Department of Neurology, University of Occupational and Environmental Health, Fukuoka, Japan (Z.H.); Department of Physiology and Pathophysiology, Yanbian University College of Medicine, Yanji, China (H.J.); Division of Cardiology, Department of Internal Medicine, Kyung Hee University, Seoul, South Korea (X.W.C); and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (G.P.S.).
authors.forename: Haiying
authors.initials: H
authors.lastname: Jiang
authors.affiliation: From the Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (H.W., Q. Du, S.L., Q. Dai); Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan (H.W., X.W.C., K.T., M.Y., T.M.); Department of Pathology and Cell Biology, University of South Florida Morsani College of Medicine, Tampa, FL (C.H., X.Z.); Department of Cardiology, Yanbian University Hospital, Yanji, China (X.W.C., X.L., E.Z., G.Z., L.P., Y.L.); Department of and Community Healthcare & Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan (X.W.C., L.H., A.I., M.K.); Department of Neurology, University of Occupational and Environmental Health, Fukuoka, Japan (Z.H.); Department of Physiology and Pathophysiology, Yanbian University College of Medicine, Yanji, China (H.J.); Division of Cardiology, Department of Internal Medicine, Kyung Hee University, Seoul, South Korea (X.W.C); and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (G.P.S.).
authors.forename: Yanna
authors.initials: Y
authors.lastname: Lei
authors.affiliation: From the Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (H.W., Q. Du, S.L., Q. Dai); Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan (H.W., X.W.C., K.T., M.Y., T.M.); Department of Pathology and Cell Biology, University of South Florida Morsani College of Medicine, Tampa, FL (C.H., X.Z.); Department of Cardiology, Yanbian University Hospital, Yanji, China (X.W.C., X.L., E.Z., G.Z., L.P., Y.L.); Department of and Community Healthcare & Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan (X.W.C., L.H., A.I., M.K.); Department of Neurology, University of Occupational and Environmental Health, Fukuoka, Japan (Z.H.); Department of Physiology and Pathophysiology, Yanbian University College of Medicine, Yanji, China (H.J.); Division of Cardiology, Department of Internal Medicine, Kyung Hee University, Seoul, South Korea (X.W.C); and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (G.P.S.).
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Zhang
authors.affiliation: From the Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (H.W., Q. Du, S.L., Q. Dai); Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan (H.W., X.W.C., K.T., M.Y., T.M.); Department of Pathology and Cell Biology, University of South Florida Morsani College of Medicine, Tampa, FL (C.H., X.Z.); Department of Cardiology, Yanbian University Hospital, Yanji, China (X.W.C., X.L., E.Z., G.Z., L.P., Y.L.); Department of and Community Healthcare & Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan (X.W.C., L.H., A.I., M.K.); Department of Neurology, University of Occupational and Environmental Health, Fukuoka, Japan (Z.H.); Department of Physiology and Pathophysiology, Yanbian University College of Medicine, Yanji, China (H.J.); Division of Cardiology, Department of Internal Medicine, Kyung Hee University, Seoul, South Korea (X.W.C); and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (G.P.S.).
authors.forename: Shaowen
authors.initials: S
authors.lastname: Liu
authors.affiliation: From the Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (H.W., Q. Du, S.L., Q. Dai); Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan (H.W., X.W.C., K.T., M.Y., T.M.); Department of Pathology and Cell Biology, University of South Florida Morsani College of Medicine, Tampa, FL (C.H., X.Z.); Department of Cardiology, Yanbian University Hospital, Yanji, China (X.W.C., X.L., E.Z., G.Z., L.P., Y.L.); Department of and Community Healthcare & Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan (X.W.C., L.H., A.I., M.K.); Department of Neurology, University of Occupational and Environmental Health, Fukuoka, Japan (Z.H.); Department of Physiology and Pathophysiology, Yanbian University College of Medicine, Yanji, China (H.J.); Division of Cardiology, Department of Internal Medicine, Kyung Hee University, Seoul, South Korea (X.W.C); and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (G.P.S.).
authors.forename: Qiuyan
authors.initials: Q
authors.lastname: Dai
authors.affiliation: From the Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (H.W., Q. Du, S.L., Q. Dai); Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan (H.W., X.W.C., K.T., M.Y., T.M.); Department of Pathology and Cell Biology, University of South Florida Morsani College of Medicine, Tampa, FL (C.H., X.Z.); Department of Cardiology, Yanbian University Hospital, Yanji, China (X.W.C., X.L., E.Z., G.Z., L.P., Y.L.); Department of and Community Healthcare & Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan (X.W.C., L.H., A.I., M.K.); Department of Neurology, University of Occupational and Environmental Health, Fukuoka, Japan (Z.H.); Department of Physiology and Pathophysiology, Yanbian University College of Medicine, Yanji, China (H.J.); Division of Cardiology, Department of Internal Medicine, Kyung Hee University, Seoul, South Korea (X.W.C); and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (G.P.S.).
authors.forename: Masafumi
authors.initials: M
authors.lastname: Kuzuya
authors.affiliation: From the Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (H.W., Q. Du, S.L., Q. Dai); Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan (H.W., X.W.C., K.T., M.Y., T.M.); Department of Pathology and Cell Biology, University of South Florida Morsani College of Medicine, Tampa, FL (C.H., X.Z.); Department of Cardiology, Yanbian University Hospital, Yanji, China (X.W.C., X.L., E.Z., G.Z., L.P., Y.L.); Department of and Community Healthcare & Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan (X.W.C., L.H., A.I., M.K.); Department of Neurology, University of Occupational and Environmental Health, Fukuoka, Japan (Z.H.); Department of Physiology and Pathophysiology, Yanbian University College of Medicine, Yanji, China (H.J.); Division of Cardiology, Department of Internal Medicine, Kyung Hee University, Seoul, South Korea (X.W.C); and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (G.P.S.).
authors.forename: Guo-Ping
authors.initials: GP
authors.lastname: Shi
authors.affiliation: From the Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (H.W., Q. Du, S.L., Q. Dai); Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan (H.W., X.W.C., K.T., M.Y., T.M.); Department of Pathology and Cell Biology, University of South Florida Morsani College of Medicine, Tampa, FL (C.H., X.Z.); Department of Cardiology, Yanbian University Hospital, Yanji, China (X.W.C., X.L., E.Z., G.Z., L.P., Y.L.); Department of and Community Healthcare & Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan (X.W.C., L.H., A.I., M.K.); Department of Neurology, University of Occupational and Environmental Health, Fukuoka, Japan (Z.H.); Department of Physiology and Pathophysiology, Yanbian University College of Medicine, Yanji, China (H.J.); Division of Cardiology, Department of Internal Medicine, Kyung Hee University, Seoul, South Korea (X.W.C); and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (G.P.S.).
authors.forename: Toyoaki
authors.initials: T
authors.lastname: Murohara
mesh_terms: D000818:Animals; D020212:Carotid Artery Injuries / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D017536:Carotid Artery, Common / Q000187:drug effects / Q000201:enzymology* / Q000473:pathology; D002403:Cathepsins / Q000037:antagonists & inhibitors / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D059447:Cell Cycle Checkpoints; D002465:Cell Movement; D049109:Cell Proliferation; D002478:Cells, Cultured; D004195:Disease Models, Animal; D005838:Genotype; D000073864:Histone Deacetylase 6; D056572:Histone Deacetylase Inhibitors / Q000494:pharmacology; D006655:Histone Deacetylases / Q000235:genetics / Q000378:metabolism*; D008297:Male; D018345:Mice, Knockout; D009131:Muscle, Smooth, Vascular / Q000201:enzymology / Q000473:pathology; D032389:Myocytes, Smooth Muscle / Q000201:enzymology / Q000473:pathology; D058426:Neointima; D010641:Phenotype; D058539:Phosphatidylinositol 3-Kinase / Q000378:metabolism*; D010766:Phosphorylation; D011480:Protease Inhibitors / Q000494:pharmacology; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D034622:RNA Interference; D015398:Signal Transduction; D051195:Toll-Like Receptor 2 / Q000235:genetics / Q000378:metabolism*; D014162:Transfection; D066253:Vascular Remodeling; D014945:Wound Healing / Q000187:drug effects; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism*
chemical_list: D056572:Histone Deacetylase Inhibitors; D011480:Protease Inhibitors; C493486:Tlr2 protein, mouse; D051195:Toll-Like Receptor 2; D058539:Phosphatidylinositol 3-Kinase; D051057:Proto-Oncogene Proteins c-akt; D048051:p38 Mitogen-Activated Protein Kinases; D002403:Cathepsins; C028217:cathepsin S; C499033:Hdac6 protein, mouse; D000073864:Histone Deacetylase 6; D006655:Histone Deacetylases
keywords: HDAC6; cathepsin S; neointimal formation; vascular remodeling