title: Clustered ventilation defects and bilinear respiratory reactance in asthma.
abstract: Imaging studies of asthmatics typically reveal clustered ventilation patterns, rather than homogeneous ventilation; furthermore, the variation of these clusters suggests that the causes are at least partially dynamic, rather than structural. Theoretical studies have indicated dynamic mechanisms by which homogeneous ventilation solutions lose stability and clustered solutions emerge. At the same time, it has been demonstrated experimentally that respiratory reactance characteristically has a bilinear relationship with lung volume, and that changes to this relationship are indicative of various aspects of disease progression and control. Moreover, the transition point in the bilinear reactance relationship is thought to relate to reopening/recruitment of airway units, and thus may be connected to the bifurcation via which clustered ventilation solutions emerge. In order to investigate this possibility we develop a new model, including both airway-airway coupling and airway-parenchymal coupling, which exhibits both clustered ventilation defects and also a bilinear reactance relationship. Studying this model reveals that (1) the reactance breakpoint is not coincident with the bifurcation; (2) numerous changes to underlying behaviour can alter the reactance breakpoint in ways which mimic the experimental data; and (3) the location of ventilation defects can be a combination of both structural and dynamic factors.
authors.affiliation: Department of Mathematics, University of Auckland, Private Bag 92019, Auckland, New Zealand. Electronic address: g.donovan@auckland.ac.nz.
authors.forename: Graham M
authors.initials: GM
authors.lastname: Donovan
mesh_terms: D001249:Asthma / Q000503:physiopathology*; D016000:Cluster Analysis; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D009716:Numerical Analysis, Computer-Assisted; D012123:Pulmonary Ventilation / Q000502:physiology*
keywords: Airway hyper-responsiveness; Bronchoconstriction; Heterogeneity