title: Quinolones in the Search for New Anticancer Agents.
abstract: Quinolones have a large bio-dynamicity. Although they are well known as antibacterials, another important activity has been investigated - quinolones are able to inhibit cancer cell proliferation. In view of the great versatility associated with the synthesis of quinolones, many researchers have spent time and resources on the development of new structurally diversified quinolone derivatives with the purpose of finding new possibilities for cancer treatment. In this review some of the most recent advances in the search for new quinolone anticancer agents are highlighted, with focus on naturally occurring substances, bioactive metal complexes, molecular hybrids, photosensitizers and heterocycle condensed quinolones.
authors.forename: Pedro Netto
authors.initials: PN
authors.lastname: Batalha
authors.forename: Maria Cecília Bastos
authors.initials: MC
authors.lastname: Vieira de Souza
authors.forename: Eduardo
authors.initials: E
authors.lastname: Peña-Cabrera
authors.forename: David Cruz
authors.initials: DC
authors.lastname: Cruz
authors.affiliation: Department of Organic Chemistry, Chemistry Institute, Federal Fluminense University, Outeiro de São João Batista s/n 24020-150, Niterói, Brazil.
authors.forename: Fernanda
authors.initials: F
authors.lastname: da Costa Santos Boechat
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D015363:Quinolones / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D015363:Quinolones