title: Self-reported reasons for treatment non-adherence in Chinese asthma patients: A 24-week prospective telephone follow-up study.
abstract: BACKGROUND
  Treatment non-adherence is a challenge to achieve asthma control. However, few prospective studies were done for exploring asthma patient adherence in real world.
  
  
  OBJECTIVE
  To evaluate treatment adherence and causes of non-adherence in a large asthma Chinese population. To analyze newly-diagnosed patients' adherence first time.
  
  
  METHODS
  About 1582 asthma patients' data were collected from 12 study centers in China from February, 2012 to October, 2012. Disease and treatment information of subjects were collected were at first clinic visit, at 4, 12, and 24 weeks after that, follow-up phone calls were carried out for recording subjects' treatment adherence based on their self-reports. Subjects who reported non-adherence were additionally asked to choose the primary non-adherence cause from a list of nine potential causes.
  
  
  RESULTS
  Treatment adherence rate of all subjects markedly decreased from 83.3% at week 4 to 42.0% at week 24 after the first clinic visit. Significantly, at week 24, good treatment adherence rate in newly-diagnosed patients was lower than those patients with asthma history (22.9% vs. 63.9%, P < .001). Newly-diagnosed patients were three times more likely to become non-adherence than those patients with asthma history. Female patients had lower treatment adherence rate than male patients (38.3% vs. 45.6%, P = .006). Subjects in 30-39 year age group had the worst treatment adherence (27.3%). The most commonly chosen cause for non-adherence was "relief of symptoms after short-term controller medication use" (43.8%).
  
  
  CONCLUSIONS
  Asthma patients' treatment adherence could be improved by improving patient education, doctor/patient partnership, and level of medical service in Chinese population.
authors.affiliation: Institute of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Qianli
authors.initials: Q
authors.lastname: Ma
authors.affiliation: Department of Respiratory Medicine, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Guangming
authors.initials: G
authors.lastname: Luo
authors.affiliation: Department of Respiratory Medicine, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Department of Respiratory Medicine, Children's Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Respiratory Medicine, Children's Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Enmei
authors.initials: E
authors.lastname: Liu
authors.affiliation: Department of Respiratory Medicine, Daping Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Hong
authors.affiliation: Department of Respiratory Medicine, Chongqing Three Gorges Central Hospital, Chongqing, China.
authors.forename: Liangping
authors.initials: L
authors.lastname: Mao
authors.affiliation: Department of Respiratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Yamei
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Respiratory Medicine, No.324 Hospital of Chinese PLA.
authors.forename: Xumei
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Respiratory Medicine, Fuling Center Hospital of Chongqing, Chongqing, China.
authors.forename: Xiuqing
authors.initials: X
authors.lastname: Liao
authors.affiliation: Department of Respiratory Medicine, Yongchuan Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Guangmei
authors.initials: G
authors.lastname: Qin
authors.affiliation: Department of Respiratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Daoxin
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Respiratory Medicine, Jiangjin Central Hospital, Chongqing, China.
authors.forename: Lian
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Respiratory Medicine, Chonggang Zong Hospital, Chongqing, China.
authors.forename: Shifu
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Institute of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Changzheng
authors.initials: C
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001249:Asthma / Q000188:drug therapy* / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D057566:Self Report; D013689:Telephone; D013997:Time Factors; D055815:Young Adult; D016903:Drug Monitoring
keywords: doctor/patient communication; patient education; self-report; treatment adherence