title: Different methods for subgingival application of chlorhexidine in the treatment of patients with chronic periodontitis.
abstract: OBJECTIVE
  The aim of this study was to evaluate clinical efficacy of different chlorhexidine gluconate (CHX) preparations applied subgingivally as an adjunct to scaling and root planing (SRP).
  
  
  METHODS
  A total of 120 periodontal pockets was included in this randomized, controlled, split mouth designed study. According to protocols used in treatment, periodontal pockets were assigned to experimental and control groups as follows: CHX solution as an addition to SRP versus control SRP group; CHX gel as an addition to SRP versus control SRP; CHX chip as an addition to SRP versus control SRP group. Following clinical parameters were recorded at baseline, one and three months after the baseline: plaque index (PI), probing pocket depth (PPD), bleeding index (BI) and clinical attachment level (CAL).
  
  
  RESULTS
  The most significant improvements were found concerning PI in CHX solution with SRP and CHX gel with SRP groups over controls at one month recall, as well as concerning BI and PPD in CHX chip with SRP group over SRP alone at three-month recall.
  
  
  CONCLUSIONS
  Results of this study favour combination therapy using CHX chip as an adjunct to SRP due to greater improvements in BI and PPD compared to those obtained by SRP alone in the treatment of chronic periodontitis.
authors.affiliation: a Department of Periodontology and Oral Medicine , University of East Sarajevo, Faculty of Medicine, Dentistry Program , Foca , Bosnia and Herzegovina ;
authors.forename: Jelena
authors.initials: J
authors.lastname: Lecic
authors.affiliation: b Department of Periodontology and Oral Medicine , University of Belgrade, Faculty of Dental Medicine , Belgrade , Serbia ;
authors.forename: Sasa
authors.initials: S
authors.lastname: Cakic
authors.affiliation: c Department of Prosthodontics , University of East Sarajevo, Faculty of Medicine, Dentistry Program , Foca , Bosnia and Herzegovina ;
authors.forename: Ognjenka
authors.initials: O
authors.lastname: Janjic Pavlovic
authors.affiliation: a Department of Periodontology and Oral Medicine , University of East Sarajevo, Faculty of Medicine, Dentistry Program , Foca , Bosnia and Herzegovina ;
authors.forename: Ana
authors.initials: A
authors.lastname: Cicmil
authors.affiliation: a Department of Periodontology and Oral Medicine , University of East Sarajevo, Faculty of Medicine, Dentistry Program , Foca , Bosnia and Herzegovina ;
authors.forename: Olivera
authors.initials: O
authors.lastname: Vukotic
authors.affiliation: d Department of Pediatric and Preventive Dentistry , University of Belgrade, Faculty of Dental Medicine , Belgrade , Serbia.
authors.forename: Vanja
authors.initials: V
authors.lastname: Petrovic
authors.affiliation: a Department of Periodontology and Oral Medicine , University of East Sarajevo, Faculty of Medicine, Dentistry Program , Foca , Bosnia and Herzegovina ;
authors.forename: Smiljka
authors.initials: S
authors.lastname: Cicmil
mesh_terms: D000328:Adult; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D002710:Chlorhexidine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D055113:Chronic Periodontitis / Q000188:drug therapy* / Q000517:prevention & control; D003774:Dental Plaque Index; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000188:drug therapy*; D016037:Single-Blind Method
chemical_list: D000891:Anti-Infective Agents, Local; C010882:chlorhexidine gluconate; D002710:Chlorhexidine
keywords: Periodontitis; antimicrobials; chlorhexidine gluconate; local drug delivery; scaling and root planing