title: Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus.
abstract: Systemic lupus erythematosus (SLE; OMIM 152700) is a genetically complex autoimmune disease. Genome-wide association studies (GWASs) have identified more than 50 loci as robustly associated with the disease in single ancestries, but genome-wide transancestral studies have not been conducted. We combined three GWAS data sets from Chinese (1,659 cases and 3,398 controls) and European (4,036 cases and 6,959 controls) populations. A meta-analysis of these studies showed that over half of the published SLE genetic associations are present in both populations. A replication study in Chinese (3,043 cases and 5,074 controls) and European (2,643 cases and 9,032 controls) subjects found ten previously unreported SLE loci. Our study provides further evidence that the majority of genetic risk polymorphisms for SLE are contained within the same regions across both populations. Furthermore, a comparison of risk allele frequencies and genetic risk scores suggested that the increased prevalence of SLE in non-Europeans (including Asians) has a genetic basis.
authors.affiliation: Division of Genetics and Molecular Medicine, King's College London, London, UK.
authors.forename: David L
authors.initials: DL
authors.lastname: Morris
authors.affiliation: Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui, China.|Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, Anhui, China.|Department of Dermatology, China-Japan Friendship Hospital, Beijing, China.
authors.forename: Yujun
authors.initials: Y
authors.lastname: Sheng
authors.affiliation: Department of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.
authors.forename: Yong-Fei
authors.initials: YF
authors.lastname: Wang
authors.affiliation: Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui, China.|Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, Anhui, China.
authors.forename: Zhengwei
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: Division of Genetics and Molecular Medicine, King's College London, London, UK.
authors.forename: Philip
authors.initials: P
authors.lastname: Tombleson
authors.affiliation: Division of Genetics and Molecular Medicine, King's College London, London, UK.
authors.forename: Lingyan
authors.initials: L
authors.lastname: Chen
authors.affiliation: Division of Genetics and Molecular Medicine, King's College London, London, UK.
authors.forename: Deborah S
authors.initials: DS
authors.lastname: Cunninghame Graham
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
authors.forename: James
authors.initials: J
authors.lastname: Bentham
authors.affiliation: Division of Genetics and Molecular Medicine, King's College London, London, UK.
authors.forename: Amy L
authors.initials: AL
authors.lastname: Roberts
authors.affiliation: Department of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.
authors.forename: Ruoyan
authors.initials: R
authors.lastname: Chen
authors.affiliation: Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui, China.|Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, Anhui, China.
authors.forename: Xianbo
authors.initials: X
authors.lastname: Zuo
authors.affiliation: Department of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.
authors.forename: Tingyou
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui, China.|Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, Anhui, China.
authors.forename: Leilei
authors.initials: L
authors.lastname: Wen
authors.affiliation: Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui, China.|Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, Anhui, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Yang
authors.affiliation: Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui, China.|Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, Anhui, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui, China.|Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, Anhui, China.
authors.forename: Lulu
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui, China.|Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, Anhui, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui, China.|Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, Anhui, China.
authors.forename: Yuanbo
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui, China.|Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, Anhui, China.
authors.forename: Xianyong
authors.initials: X
authors.lastname: Yin
authors.affiliation: Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui, China.|Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, Anhui, China.
authors.forename: Sen
authors.initials: S
authors.lastname: Yang
authors.affiliation: Department of Medical Sciences, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
authors.forename: Lars
authors.initials: L
authors.lastname: Rönnblom
authors.affiliation: Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany.|Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.|Division of Genetic Epidemiology, Medical University Innsbruck, Innsbruck, Austria.|Division of Biological Chemistry, Medical University Innsbruck, Innsbruck, Austria.
authors.forename: Barbara G
authors.initials: BG
authors.lastname: Fürnrohr
authors.affiliation: Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany.|Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.|Department of Rheumatology, University Hospital Freiburg, Freiburg, Germany.|Department of Rheumatology and Clinical Immunology, University Hospital Freiburg, Freiburg, Germany.|Centre for Chronic Immunodeficiency, University Hospital Freiburg, Freiburg, Germany.
authors.forename: Reinhard E
authors.initials: RE
authors.lastname: Voll
authors.affiliation: Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany.|Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.
authors.forename: Georg
authors.initials: G
authors.lastname: Schett
authors.affiliation: AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Paris, France.|Université Paris Descartes-Sorbonne Paris Cité, Paris, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Costedoat-Chalumeau
authors.affiliation: Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.
authors.forename: Patrick M
authors.initials: PM
authors.lastname: Gaffney
authors.affiliation: Department of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.|The University of Hong Kong Shenzhen Hospital, Shenzhen, China.
authors.forename: Yu Lung
authors.initials: YL
authors.lastname: Lau
authors.affiliation: Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui, China.|Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, Anhui, China.|Department of Dermatology, Huashan Hospital of Fudan University, Shanghai, China.
authors.forename: Xuejun
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.
authors.forename: Wanling
authors.initials: W
authors.lastname: Yang
authors.affiliation: Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui, China.|Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, Anhui, China.|Department of Dermatology, China-Japan Friendship Hospital, Beijing, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Cui
authors.affiliation: Division of Genetics and Molecular Medicine, King's College London, London, UK.|Division of Immunology, Infection and Inflammatory Disease, King's College London, London, UK.
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Vyse
mesh_terms: D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D056426:Genetic Loci / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D044465:White People / Q000235:genetics*