title: The effects of healthy aging, amnestic mild cognitive impairment, and Alzheimer's disease on recollection, familiarity and false recognition, estimated by an associative process-dissociation recognition procedure.
abstract: Given the uneven experimental results in the literature regarding whether or not familiarity declines with healthy aging and cognitive impairment, we compare four samples (healthy young people, healthy older people, older people with amnestic mild cognitive impairment - aMCI -, and older people with Alzheimer's disease - AD -) on an associative recognition task, which, following the logic of the process-dissociation procedure, allowed us to obtain corrected estimates of recollection, familiarity and false recognition. The results show that familiarity does not decline with healthy aging, but it does with cognitive impairment, whereas false recognition increases with healthy aging, but declines significantly with cognitive impairment. These results support the idea that the deficits detected in recollection, familiarity, or false recognition in older people could be used as early prodromal markers of cognitive impairment.
authors.affiliation: University of Valencia, Spain. Electronic address: pitarque@uv.es.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Pitarque
authors.affiliation: University of Valencia, Spain.
authors.forename: Juan C
authors.initials: JC
authors.lastname: Meléndez
authors.affiliation: University of Valencia, Spain.
authors.forename: Alicia
authors.initials: A
authors.lastname: Sales
authors.affiliation: University of Valencia, Spain.
authors.forename: Teresa
authors.initials: T
authors.lastname: Mayordomo
authors.affiliation: University of Valencia, Spain.
authors.forename: Encar
authors.initials: E
authors.lastname: Satorres
authors.affiliation: Department of Neurology, General Hospital, Valencia, Spain.
authors.forename: Joaquín
authors.initials: J
authors.lastname: Escudero
authors.affiliation: University of Valencia, Spain.
authors.forename: Salvador
authors.initials: S
authors.lastname: Algarabel
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000523:psychology*; D000544:Alzheimer Disease / Q000523:psychology*; D001244:Association; D060825:Cognitive Dysfunction / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D011939:Mental Recall; D011581:Psychological Tests; D021641:Recognition, Psychology; D055815:Young Adult
keywords: Alzheimer's disease; Cognitive impairment; False recognition; Familiarity; Recollection