title: Splenectomy versus Partial Splenic Embolization for Massive Splenomegaly Secondary to Hepatitis B-Related Liver Cirrhosis: A Case-Control Study.
abstract: Background. Both splenectomy (SP) and partial splenic embolization (PSE) are used to treat massive splenomegaly (MSM) secondary to hepatitis B-related liver cirrhosis (HB-LC). This retrospective case-control study was conducted to compare the effects of SP and PSE on these patients. Methods. From July 2004 to January 2012, patients with MSM secondary to HB-LC who underwent SP or PSE were 1 : 1 : 1 matched with similar nonsurgery patients, respectively. Intraoperative situation, hematological indices, liver function, HBV DNA level, HBeAg seroconversion rate, morbidity, and mortality at 6 months postoperatively were compared. Results. Operative time, estimated blood loss, blood transfusion rate, severe pain, postoperative stay, and portal vein thrombosis (PVT) rate in the PSE group were significantly superior to the SP group, although SP and PSE were similar in liver function improvement, HBV suppression, morbidity, and mortality at 6 months postoperatively, and SP even improved WBC and PLT counts higher than PSE. Conclusion. Both SP and PSE are effective in improving liver function, increasing WBC and PLT counts, and suppressing replication of HBV for MSM secondary to HB-LC. Although postoperative improvement in WBC and PLT counts by SP can be higher than PSE, PSE is simple and minimally invasive and has a lower incidence of PVT.
authors.affiliation: Department of Hepatobiliary Surgery, Peking University People's Hospital, Beijing 100044, China.
authors.forename: Shoufei
authors.identifier: 0000-0003-0388-0296
authors.initials: S
authors.lastname: Jiao
authors.affiliation: Chinese PLA Medical School and Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Hongxing
authors.identifier: 0000-0001-6219-7273
authors.initials: H
authors.lastname: Chen
authors.affiliation: Chinese PLA Medical School and Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Youlong
authors.identifier: 0000-0002-0289-7005
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Hepatobiliary Surgery, Peking University People's Hospital, Beijing 100044, China.
authors.forename: Jiye
authors.identifier: 0000-0003-0456-7584
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Chinese PLA Medical School and Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Jingwang
authors.identifier: 0000-0003-2363-6071
authors.initials: J
authors.lastname: Tan
authors.affiliation: Department of Hepatobiliary Surgery, Peking University People's Hospital, Beijing 100044, China.
authors.forename: Jie
authors.identifier: 0000-0002-5265-1652
authors.initials: J
authors.lastname: Gao