title: Genetic heterogeneity of platelet glycoproteins Ia and IIIa and the risk of spontaneous miscarriages.
abstract: OBJECTIVE
  The aim of this study was to investigate the association between the genetic heterogeneity of platelet glycoproteins Ia (GpIa-C807T) and IIIa (GpIIIa-PlA1/PlA2) and spontaneous abortions.
  
  
  METHODS
  Two hundred and twenty two women with a history of unexplained spontaneous miscarriages and no successful pregnancy, and 60 fertile women serving as controls were genotyped for the GpIa-C807T and GpIIIa-PlA1/PlA2 polymorphisms by pyrosequencing.
  
  
  RESULTS
  In comparison with the common alleles homozygotes, GpIa-807T and GpIIIa-PlA2 carriers had an increased risk of fetal loss (OR = 3.36, 95%CI: 1.85-6.11, p < 0.001, and OR = 2.58, 95%CI: 1.30-5.13, p = 0.006, respectively). For subjects who were combined carriers of the GpIa-807T and GpIIIa-PlA2 alleles, the risk increased further (OR = 9.13, 95%CI: 2.99-27.82, p < 0.001). The above ORs were highest for women who were younger than 30 years of age.
  
  
  CONCLUSIONS
  The GpIa-C807T and GpIIIa-PlA1/PlA2 polymorphisms and more pronouncedly their combination are associated with increased risk of spontaneous abortions. The correlations were stronger for younger patients. Our results indicate that GpIa-807T and GpIIIa-PlA2 are susceptibility alleles for fetal loss in the Greek population.
authors.affiliation: a Clinical Laboratory of Therapeutic Individualization, Second Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, School of Medicine, Aretaieio Hospital , Athens , Greece.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Vlachadis
authors.affiliation: a Clinical Laboratory of Therapeutic Individualization, Second Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, School of Medicine, Aretaieio Hospital , Athens , Greece.
authors.forename: Vasileios
authors.initials: V
authors.lastname: Tsamadias
authors.affiliation: b Department of Obstetrics and Gynecology , National and Kapodistrian University of Athens, School of Medicine, Aretaieio Hospital , Athens , Greece , and.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Vrachnis
authors.affiliation: c Department of Microbiology and Biochemistry , National and Kapodistrian University of Athens, School of Medicine, Aretaieio Hospital , Athens , Greece.
authors.forename: Georgios
authors.initials: G
authors.lastname: Kaparos
authors.affiliation: b Department of Obstetrics and Gynecology , National and Kapodistrian University of Athens, School of Medicine, Aretaieio Hospital , Athens , Greece , and.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Vitoratos
authors.affiliation: a Clinical Laboratory of Therapeutic Individualization, Second Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, School of Medicine, Aretaieio Hospital , Athens , Greece.|c Department of Microbiology and Biochemistry , National and Kapodistrian University of Athens, School of Medicine, Aretaieio Hospital , Athens , Greece.
authors.forename: Evaggelia
authors.initials: E
authors.lastname: Kouskouni
authors.affiliation: a Clinical Laboratory of Therapeutic Individualization, Second Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, School of Medicine, Aretaieio Hospital , Athens , Greece.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Economou
mesh_terms: D000022:Abortion, Spontaneous / Q000235:genetics*; D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D006580:Genetic Carrier Screening; D018740:Genetic Heterogeneity; D005838:Genotype; D006801:Humans; D039421:Integrin alpha2 / Q000235:genetics*; D039661:Integrin beta3 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D012307:Risk Factors; D055815:Young Adult
chemical_list: D039421:Integrin alpha2; D039661:Integrin beta3
keywords: GpIIIa; GpIa; Miscarriage; integrin alpha2; integrin beta3; platelet glycoproteins; polymorphisms; thrombophilia