title: Estrogen receptor gene polymorphism in patients with degenerative lumbar scoliosis.
abstract: OBJECTIVE
  To examine the association between development of degenerative lumbar scoliosis (DLS) and sex hormones.
  
  
  METHODS
  We investigated the association between DLS and estrogen receptor alpha (ERα) gene polymorphisms in 184 patients with a diagnosis of DLS, by determining the presences of the Pvu II and Xba I polymorphisms, measuring bone mineral densities at the lumbar spine (LSBMD) and femoral neck (FNBMD), and by investigating biochemical markers of bone turnover and comparing these results with those of 220 healthy normal controls.
  
  
  RESULTS
  Genotype frequencies in DLS patients and controls revealed a significant difference for the Pvu II polymorphism only (p = 0.0287). No significant difference was found between the DLS and control groups with respect to the Xba I polymorphism, bone mineral density (BMD), or biochemical markers. Furthermore, no significant association was observed between the Pvu II polymorphism and BMD, lumbar scoliosis, lateral listhesis, or biochemical markers in patients with DLS.
  
  
  CONCLUSIONS
  These results suggest that the ERα Pvu II polymorphism influences the prevalence of DLS.
authors.affiliation: a Department of Orthopaedic Surgery , Sehung Hospital , Busan , Republic of Korea.
authors.forename: Yang Soo
authors.initials: YS
authors.lastname: Park
authors.affiliation: b Department of Orthopaedic Surgery, Medical Research Institute , Pusan National University Yangsan Hospital , Yangsan , Republic of Korea.
authors.forename: Kuen Tak
authors.initials: KT
authors.lastname: Suh
authors.affiliation: c Department of Orthopaedic Surgery, Medical Research Institute , Pusan National University School of Medicine , Busan , Republic of Korea.
authors.forename: Jong Ki
authors.initials: JK
authors.lastname: Shin
authors.affiliation: c Department of Orthopaedic Surgery, Medical Research Institute , Pusan National University School of Medicine , Busan , Republic of Korea.
authors.forename: Jung Sub
authors.initials: JS
authors.lastname: Lee
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D015415:Biomarkers; D015519:Bone Density / Q000235:genetics; D015257:DNA-Cytosine Methylases / Q000235:genetics; D047628:Estrogen Receptor alpha / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D055959:Intervertebral Disc Degeneration / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D015995:Prevalence; D012600:Scoliosis / Q000453:epidemiology / Q000235:genetics*; D015265:Site-Specific DNA-Methyltransferase (Adenine-Specific) / Q000235:genetics
chemical_list: D015415:Biomarkers; C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; C047084:DNA modification methylase PvuII; C059639:DNA modification methylase XbaI; D015257:DNA-Cytosine Methylases; D015265:Site-Specific DNA-Methyltransferase (Adenine-Specific)
keywords: Degenerative lumbar scoliosis; estrogen receptor gene; polymorphism