title: Pancreatic Acinar Cell Carcinoma.
abstract: Pancreatic acinar cell carcinoma (ACC) is a rare malignant neoplasm that accounts for 1-2% of all pancreatic neoplasms. Here we report two cases of ACC and describe their clinical features, the therapies used to treat them, and their prognosis. The first patient was a 65-year-old woman who had an abdominal CT scan for a urinary infection. Fortuitously, a rounded and well-delimited corporeal pancreatic tumor was discovered. An endoscopic ultrasound (EUS)-guided fine needle aspiration revealed an ACC. During the puncture, a hypoechoic cavity appeared inside the lesion, corresponding to a probable necrotic area. Treatment consisted of a distal splenopancreatectomy. The second patient was a 75-year-old man who complained of abdominal pain. An abdominal CT scan showed a cephalic pancreatic lesion and two hepatic metastases. An EUS-guided fine needle aspiration showed a pancreatic ACC. The patient received chemotherapy with gemcitabine plus oxaliplatin (GEMOX regimen), which enabled an objective response after 6 cycles.
authors.affiliation: Groupe Digestif, Institut Bergonié, Bordeaux, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Béchade
authors.affiliation: Groupe Digestif, Institut Bergonié, Bordeaux, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Desjardin
authors.affiliation: Groupe Digestif, Institut Bergonié, Bordeaux, France.
authors.forename: Emma
authors.initials: E
authors.lastname: Salmon
authors.affiliation: Groupe Digestif, Institut Bergonié, Bordeaux, France.
authors.forename: Grégoire
authors.initials: G
authors.lastname: Désolneux
authors.affiliation: Groupe Digestif, Institut Bergonié, Bordeaux, France.
authors.forename: Yves
authors.initials: Y
authors.lastname: Bécouarn
authors.affiliation: Groupe Digestif, Institut Bergonié, Bordeaux, France.
authors.forename: Serge
authors.initials: S
authors.lastname: Evrard
authors.affiliation: Groupe Digestif, Institut Bergonié, Bordeaux, France.
authors.forename: Marianne
authors.initials: M
authors.lastname: Fonck
keywords: Acinar cell carcinoma; Pancreas