title: Antioxidant and antibacterial activities and polyphenolic constituents of Helianthemum sessiliflorum Pers.
abstract: In this study, the various extracts of aerial parts of Helianthemum sessiliflorum Pers. were examined in vitro for possible source of antioxidants and for antibacterial activity. The antioxidant activity was performed by DPPH radical scavenging method which showed that ethyl acetate extract possessed the best antioxidant potential (IC50= 32.75 ± 2.07 μg/mL). The significant linear correlation was realised between the values of the total phenolic/flavonoid content and antioxidant activity of plant extracts. The ethyl acetate and n-butanol extracts showed moderate antibacterial activity. In addition, the phytochemical study of n-butanol extract afforded nine known phenolic compounds (1-9). This is the first report of six of them (1, 3, 5-8) in Cistaceae family. The structural identification of the isolated compounds was achieved using several spectroscopic methods.
authors.affiliation: a Laboratoire de Chimie et Chimie de l'Environnement (L.C.C.E), Faculté des Sciences de la Matière, Département de Chimie , Université de Batna-1 , Batna , Algérie.
authors.forename: Imane
authors.initials: I
authors.lastname: Benabdelaziz
authors.affiliation: b Phytochemistry and Bioactive Natural Products, School of Pharmaceutical Science, EPGL , University of Geneva , Geneva , Switzerland.
authors.forename: Laurence
authors.initials: L
authors.lastname: Marcourt
authors.affiliation: a Laboratoire de Chimie et Chimie de l'Environnement (L.C.C.E), Faculté des Sciences de la Matière, Département de Chimie , Université de Batna-1 , Batna , Algérie.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Benkhaled
authors.affiliation: b Phytochemistry and Bioactive Natural Products, School of Pharmaceutical Science, EPGL , University of Geneva , Geneva , Switzerland.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Wolfender
authors.affiliation: a Laboratoire de Chimie et Chimie de l'Environnement (L.C.C.E), Faculté des Sciences de la Matière, Département de Chimie , Université de Batna-1 , Batna , Algérie.
authors.forename: Hamada
authors.initials: H
authors.lastname: Haba
mesh_terms: D020001:1-Butanol; D000085:Acetates; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001713:Biphenyl Compounds / Q000737:chemistry; D030601:Cistaceae / Q000737:chemistry*; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology; D010851:Picrates / Q000737:chemistry; D035261:Plant Components, Aerial / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D059808:Polyphenols / Q000737:chemistry* / Q000494:pharmacology*; D012997:Solvents
chemical_list: D000085:Acetates; D000900:Anti-Bacterial Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D005419:Flavonoids; D016166:Free Radical Scavengers; D010636:Phenols; D010851:Picrates; D010936:Plant Extracts; D059808:Polyphenols; D012997:Solvents; C007650:ethyl acetate; D020001:1-Butanol; C004931:1,1-diphenyl-2-picrylhydrazyl
keywords: Cistaceae; Helianthemum sessiliflorum; NMR; antibacterial activity; antioxidant activity; polyphenol