title: On-Demand Dissolution of a Dendritic Hydrogel-based Dressing for Second-Degree Burn Wounds through Thiol-Thioester Exchange Reaction.
abstract: An adhesive yet easily removable burn wound dressing represents a breakthrough in second-degree burn wound care. Current second-degree burn wound dressings absorb wound exudate, reduce bacterial infections, and maintain a moist environment for healing, but are surgically or mechanically debrided from the wound, causing additional trauma to the newly formed tissues. We have developed an on-demand dissolvable dendritic thioester hydrogel burn dressing for second-degree burn care. The hydrogel is composed of a lysine-based dendron and a PEG-based crosslinker, which are synthesized in high yields. The hydrogel burn dressing covers the wound and acts as a barrier to bacterial infection in an in vivo second-degree burn wound model. A unique feature of the hydrogel is its capability to be dissolved on-demand, via a thiol-thioester exchange reaction, allowing for a facile burn dressing removal.
authors.affiliation: Departments of Chemistry and Biomedical Engineering, Boston University, 590 Commonwealth Ave, Boston, MA, 02215, USA.
authors.forename: Marlena D
authors.initials: MD
authors.lastname: Konieczynska
authors.affiliation: Center for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA.
authors.forename: Juan C
authors.initials: JC
authors.lastname: Villa-Camacho
authors.affiliation: Departments of Chemistry and Biomedical Engineering, Boston University, 590 Commonwealth Ave, Boston, MA, 02215, USA.
authors.forename: Cynthia
authors.initials: C
authors.lastname: Ghobril
authors.affiliation: Center for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA.
authors.forename: Miguel
authors.initials: M
authors.lastname: Perez-Viloria
authors.affiliation: Departments of Chemistry and Biomedical Engineering, Boston University, 590 Commonwealth Ave, Boston, MA, 02215, USA.
authors.forename: Kristie M
authors.initials: KM
authors.lastname: Tevis
authors.affiliation: Departments of Chemistry and Biomedical Engineering, Boston University, 590 Commonwealth Ave, Boston, MA, 02215, USA.
authors.forename: William A
authors.initials: WA
authors.lastname: Blessing
authors.affiliation: Center for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA.
authors.forename: Ara
authors.initials: A
authors.lastname: Nazarian
authors.affiliation: Center for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA.
authors.forename: Edward K
authors.initials: EK
authors.lastname: Rodriguez
authors.affiliation: Departments of Chemistry and Biomedical Engineering, Boston University, 590 Commonwealth Ave, Boston, MA, 02215, USA. mgrin@bu.edu.
authors.forename: Mark W
authors.identifier: 0000-0002-5453-3668
authors.initials: MW
authors.lastname: Grinstaff
mesh_terms: D001458:Bandages; D050091:Dendrimers / Q000737:chemistry*; D004952:Esters / Q000737:chemistry*; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D014945:Wound Healing
chemical_list: D050091:Dendrimers; D004952:Esters; D020100:Hydrogels; D013438:Sulfhydryl Compounds
keywords: dendrimers; dissolution; hydrogel; thiol-thioester exchange; wound dressing