title: Macrophage Inflammatory Protein-1 Alpha: A Paradox?
abstract: Macrophage inflammatory protein - 1 alpha (MIP-1α) is an 8kD protein which tends to form aggregates and is a member of the C-X-C chemokine subfamily, being a pro-inflammatory agent and is chemotactic for lymphocytes. MIP-1α has been shown to inhibit haemopoietic progenitor cell proliferation in vivo and in vitro and to reduce haemopoietic stem cell loss with improved neutrophil recovery after radiotherapy or chemotherapeutic agents in vivo.
authors.affiliation: a Dept Haematology , Western Infirmary , Dumbarton Rd, Glasgow G11 6NT , Scotland.
authors.forename: A N
authors.initials: AN
authors.lastname: Parker
authors.affiliation: b Cancer Research Campaign , Beatson Institute for Cancer Research , Garscube Estate, Bearsden, Glasgow G61 1BD , Scotland.
authors.forename: I B
authors.initials: IB
authors.lastname: Pragnell
keywords: MIP-1alpha; chemokine; stem cell inhibition