title: Oxidative stress markers in blood in systemic sclerosis: A meta-analysis.
abstract: OBJECTIVE
  The purpose of this study is to clarify the relationship between systemic sclerosis (SSC) and oxidative stress markers in blood.
  
  
  METHODS
  We conducted a systematic literature search of databases, including PubMed and Embase, for studies reporting circulating oxidative stress markers in patients with SSC and controls published from 1980 to December 2015. Standardized mean differences (SMDs) and 95% confidence intervals (95%CI) were calculated.
  
  
  RESULTS
  Of the 1076 articles initially retrieved, 47 were included in our meta-analysis including 12 oxidative stress markers. The concentrations of nitric oxide (SMD = 0.77; 95%CI: 0.18, 1.36; p = 0.01), malondialdehyde (SMD =1.63; 95%CI: 1.03, 2.24; p = 0.000), asymmetric dimethylarginine (SMD = 0.51; 95%CI: 0.12, 0.91; p = 0.011), and ROOH (SMD = 3.37; 95%CI: 0.28, 6.46; p = 0.033) in the blood of patients with SSC were higher than those of the control group, whereas the concentrations of superoxide dismutase (SMD = -1.11; 95%CI: -1.57, -0.65; p = 0.000) and vitamin C (SMD = -1.12; 95%CI: -1.51, -0.73; p = 0.000) were lower than in the control group.
  
  
  CONCLUSIONS
  The oxidative stress markers in blood for patients with SSC were aberrant, indicating the imbalanced states of oxidation and antioxidation in SSC.
authors.affiliation: a Department of Dermatology , Shanghai Tongji Hospital, Tongji University School of Medicine , Shanghai , China.|b Department of Dermatology , Affiliated Hospital of Guilin Medical University , Guilin , Guangxi , China.
authors.forename: Jing-Ying
authors.initials: JY
authors.lastname: Luo
authors.affiliation: c Tumor Research Institute of Yunnan Province, the Third Affiliated Hospital of Kunming Medical College , Kunming , Yunnan , China , and.
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.affiliation: a Department of Dermatology , Shanghai Tongji Hospital, Tongji University School of Medicine , Shanghai , China.
authors.forename: Miao
authors.initials: M
authors.lastname: Jiang
authors.affiliation: d Department of Dermatology , The Hospital of Shanxi University of TCM , Taiyuan , Shanxi , China.
authors.forename: Hui-Ping
authors.initials: HP
authors.lastname: Zhao
authors.affiliation: a Department of Dermatology , Shanghai Tongji Hospital, Tongji University School of Medicine , Shanghai , China.
authors.forename: Jing-Jun
authors.initials: JJ
authors.lastname: Zhao
mesh_terms: D001120:Arginine / Q000031:analogs & derivatives / Q000097:blood; D001205:Ascorbic Acid / Q000097:blood; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D006801:Humans; D008315:Malondialdehyde / Q000097:blood; D009569:Nitric Oxide / Q000097:blood; D018384:Oxidative Stress; D012595:Scleroderma, Systemic / Q000097:blood*; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D015415:Biomarkers; C487735:dimethylarginine; D009569:Nitric Oxide; D008315:Malondialdehyde; D001120:Arginine; D013482:Superoxide Dismutase; D001205:Ascorbic Acid
keywords: Marker; Meta-analysis; Oxidative stress; Systemic sclerosis