title: Synthesis and Evaluation of Thermo-Sensitive, Magnetic Fluorescent Nanocomposite as Trifunctional Drug Delivery Carrier.
abstract: The thermo-sensitive magnetic fluorescent trifunctional nanocomposite (Fe₃O₄/ZnS@PNIPAM) has been synthesized via a facile route. The obtained biocompatible nanocomposite was composed of monodisperse heterostructural Fe₃O₄/ZnS core and a thermo-sensitive poly(N-isopropyl acrylamide) (PNIPAM) shell. Fe₃O₄/ZnS acted as magnetic response and fluorescence luminous body, PNIPAM acted as drug loaded platform which can adsorb and release drug controllably. Fe₃O₄/ZnS@PNIPAM was characterized and all of the results showed that it had excellent magnetic response, photostability and thermo-sensitivity. Moreover, the drug release studies in vitro showed that the release rate increased with increasing temperature. MTT assays in model HepG2 cells demonstrated that Fe₃O₄/ZnS@PNIPAM was practically non-toxic. Thus, our results revealed that Fe₃O₄/ZnS@PNIPAM would be used in biomedical fields such as targeted drug delivery, as well as cancer diagnosis and treatment in the nearly future.
authors.forename: Wei
authors.initials: W
authors.lastname: Jiang
authors.forename: Binhua
authors.initials: B
authors.lastname: Chen
authors.forename: Juan
authors.initials: J
authors.lastname: Wu
authors.forename: Shanshan
authors.initials: S
authors.lastname: Xu
authors.forename: Renbing
authors.initials: R
authors.lastname: Tian
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000737:chemistry / Q000493:pharmacokinetics; D005290:Ferric Compounds / Q000737:chemistry / Q000493:pharmacokinetics; D005456:Fluorescent Dyes / Q000737:chemistry / Q000493:pharmacokinetics; D056945:Hep G2 Cells; D006358:Hot Temperature; D006801:Humans; D053761:Nanocomposites / Q000737:chemistry*; D013440:Sulfides / Q000737:chemistry / Q000493:pharmacokinetics; D017967:Zinc Compounds / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D000180:Acrylic Resins; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005290:Ferric Compounds; D005456:Fluorescent Dyes; D013440:Sulfides; D017967:Zinc Compounds; C000499:ferric oxide; C052970:poly-N-isopropylacrylamide; C031238:zinc sulfide