title: The impact of body habitus on outcomes after aneurysmal subarachnoid hemorrhage: a Nationwide Inpatient Sample analysis.
abstract: OBJECTIVE Although the prevalence of obesity is increasing rapidly both nationally and internationally, few studies have analyzed outcomes among obese patients undergoing cranial neurosurgery. The goal of this study, which used a nationwide data set, was to evaluate the association of both obesity and morbid obesity with treatment outcomes among patients with aneurysmal subarachnoid hemorrhage (SAH); in addition, the authors sought to analyze how postoperative complications for obese patients with SAH differ by the treatment modality used for aneurysm repair. METHODS Clinical data for adult patients with SAH who underwent microsurgical or endovascular aneurysm repair were extracted from the Nationwide Inpatient Sample (NIS). The body habitus of patients was classified as nonobese (body mass index [BMI] < 30 kg/m2), obese (BMI ≥ 30 kg/m2and ≤ 40 kg/m2), or morbidly obese (BMI > 40 kg/m2). Multivariable logistic regression analyzed the association of body habitus with in-hospital mortality rate, complications, discharge disposition, and poor outcome as defined by the composite NIS-SAH outcome measure. Covariates included patient demographics, comorbidities (including hypertension and diabetes), health insurance status, the NIS-SAH severity scale, treatment modality used for aneurysm repair, and hospital characteristics. RESULTS In total, data from 18,281 patients were included in this study; the prevalence of morbid obesity increased from 0.8% in 2002 to 3.5% in 2011. Obese and morbidly obese patients were significantly younger and had a greater number of comorbidities than nonobese patients (p < 0.001). Mortality rates for obese (11.5%) and morbidly obese patients (10.5%) did not significantly differ from those for nonobese patients (13.5%); likewise, no differences in neurological complications or poor outcome were observed among these 3 groups. Morbid obesity was associated with significantly increased odds of several medical complications, including venous thromboembolic (OR 1.52, 95% CI 1.01-2.30, p = 0.046) and renal (OR 1.64, 95% CI: 1.11-2.43, p = 0.01) complications and infections (OR 1.34, 95% CI 1.08-1.67, p = 0.009, attributable to greater odds of urinary tract and surgical site infections). Moreover, morbidly obese patients had higher odds of a nonroutine hospital discharge (OR 1.33, 95% CI 1.03-1.71, p = 0.03). Patients with milder obesity had decreased odds of some medical complications, including cardiac, pulmonary, and infectious complications, primarily among patients who had undergone coil embolization. CONCLUSIONS In this study involving a nationwide administrative database, milder obesity was not significantly associated with increased mortality rates, neurological complications, or poor outcomes after SAH. Morbid obesity, however, was associated with increased odds of venous thromboembolic, renal, and infectious complications, as well as of a nonroutine hospital discharge. Notably, milder obesity was associated with decreased odds of some medical complications, primarily in patients treated with coiling.
authors.affiliation: Cushing Neurosurgical Outcomes Center, Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
authors.forename: Hormuzdiyar H
authors.initials: HH
authors.lastname: Dasenbrock
authors.affiliation: Cushing Neurosurgical Outcomes Center, Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
authors.forename: Michael O
authors.initials: MO
authors.lastname: Nguyen
authors.affiliation: Cushing Neurosurgical Outcomes Center, Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
authors.forename: Kai U
authors.initials: KU
authors.lastname: Frerichs
authors.affiliation: Cushing Neurosurgical Outcomes Center, Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
authors.forename: Donovan
authors.initials: D
authors.lastname: Guttieres
authors.affiliation: Cushing Neurosurgical Outcomes Center, Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
authors.forename: William B
authors.initials: WB
authors.lastname: Gormley
authors.affiliation: Cushing Neurosurgical Outcomes Center, Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
authors.forename: M
authors.initials: M
authors.lastname: Ali Aziz-Sultan
authors.affiliation: Cushing Neurosurgical Outcomes Center, Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
authors.forename: Rose
authors.initials: R
authors.lastname: Du
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006760:Hospitalization; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D009767:Obesity, Morbid / Q000150:complications; D011183:Postoperative Complications / Q000453:epidemiology; D013345:Subarachnoid Hemorrhage / Q000150:complications* / Q000601:surgery*; D016896:Treatment Outcome; D014481:United States; D055815:Young Adult
keywords: ICD-9-CM = International Classification of Diseases, Ninth Edition, Clinical Modification; NIS = Nationwide Inpatient Sample; NIS-SAH-SS = NIS-SAH Severity Scale; NIS-SOM = NIS-SAH Outcome Measure; SAH = subarachnoid hemorrhage; body habitus; body mass index; cerebral aneurysm; endovascular; mRS = modified Rankin Scale; morbid obesity; subarachnoid hemorrhage; vascular disorders