title: [State of the use of magnesium sulfate for prevention of cerebral palsy in pre-term newborn in the Rouen's hospital].
abstract: OBJECTIVE
  Although the benefit of magnesium sulfate to prevent cerebral palsy in antenatal on very preterm infants has been shown, there is still reluctance to use it. The aim of this study was to conduct an assessment of our practice using magnesium sulfate to prevent cerebral palsy at Rouen University Hospital to report its feasibility and safety in order to spread its use.
  
  
  METHODS
  Unicentric and retrospective study, at the University Hospital of Rouen, between January and June 2014. All patients who delivered before 33 weeks or considered at risk of imminent delivery before 33 weeks were included (n=86).
  
  
  RESULTS
  Among the patients who delivered before 33 weeks (n=82), a magnesium sulfate loading dose was administrated in 91.5% of cases. Treatment was mainly established and monitored by midwives (98.6%), usually in the delivery room (82.4%), and with an average duration of administration of 8.9±17.5hours. The treatment had to be stopped in a patient who presented bradypnea associated with impaired consciousness.
  
  
  CONCLUSIONS
  Our study shows that magnesium sulfate can easily be prescribed in clinical practice.
authors.affiliation: Clinique gynécologique et obstétricale, CHU de Rouen, 1, rue de Germont, 76031 Rouen cedex, France.
authors.forename: J-C
authors.initials: JC
authors.lastname: Millochau
authors.affiliation: Service de néonatalogie, CHU de Rouen, 76031 Rouen cedex, France.
authors.forename: S
authors.initials: S
authors.lastname: Marret
authors.affiliation: Clinique gynécologique et obstétricale, CHU de Rouen, 1, rue de Germont, 76031 Rouen cedex, France.
authors.forename: S
authors.initials: S
authors.lastname: Oden
authors.affiliation: Clinique gynécologique et obstétricale, CHU de Rouen, 1, rue de Germont, 76031 Rouen cedex, France. Electronic address: eric.verspyck@chu-rouen.fr.
authors.forename: E
authors.initials: E
authors.lastname: Verspyck
mesh_terms: D000328:Adult; D002547:Cerebral Palsy / Q000517:prevention & control*; D005260:Female; D005602:France; D005865:Gestational Age; D006785:Hospitals, University; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000517:prevention & control*; D008278:Magnesium Sulfate / Q000008:administration & dosage*; D011247:Pregnancy; D012189:Retrospective Studies
chemical_list: D008278:Magnesium Sulfate
keywords: Cerebral palsy; Magnesium sulfate; Paralysie cérébrale; Prematurity; Prématurité; Sulfate de magnésium