title: Highly Sensitive Fluorescence Methods for the Determination of Alfuzosin, Doxazosin, Terazosin and Prazosin in Pharmaceutical Formulations, Plasma and Urine.
abstract: Polymeric ionic liquid-coated magnetic nanoparticles have been successfully prepared as adsorbents for the magnetic solid-phase extraction of four drugs, namely alfuzosin, doxazosin, terazosin and prazosin, from pharmaceutical preparations, urine samples and plasma samples. The four drugs were detected by fluorescence spectrophotometer. Several extraction parameters, including the pH of the solution; the type, ratio and volume of the desorbing reagent; the amount of adsorbent; the time of the extraction and desorption processes; and the addition of NaCl, were investigated and optimized. Linear responses were determined for the four drugs in the concentration range of 0.5 - 45 ng mL(-1). The limit of detection values for alfuzosin, doxazosin, terazosin and prazosin, which were defined as three times the standard deviation of a blank sample, were determined to be 0.035, 0.034, 0.027 and 0.028 ng mL(-1) (n = 11), respectively. Furthermore, this new method gave preconcentration factors of 114.5, 111.3, 111.1 and 108.5 for these four drugs.
authors.affiliation: School of Chemistry and Material Science, Shanxi Normal University.
authors.forename: Xiaozhen
authors.initials: X
authors.lastname: Guo
authors.forename: Hao
authors.initials: H
authors.lastname: Wu
authors.forename: Shiwen
authors.initials: S
authors.lastname: Guo
authors.forename: Yating
authors.initials: Y
authors.lastname: Shi
authors.forename: Juanli
authors.initials: J
authors.lastname: DU
authors.forename: Panpan
authors.initials: P
authors.lastname: Zhu
authors.forename: Liming
authors.initials: L
authors.lastname: DU
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists / Q000032:analysis / Q000097:blood* / Q000652:urine*; D006801:Humans; D057230:Limit of Detection; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D008297:Male; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011470:Prostatic Hyperplasia / Q000097:blood / Q000652:urine; D015203:Reproducibility of Results; D052616:Solid Phase Extraction / Q000379:methods*; D013050:Spectrometry, Fluorescence / Q000379:methods*
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D058185:Magnetite Nanoparticles; D004364:Pharmaceutical Preparations