title: 16-Channel Organic Electrochemical Transistor Array for In Vitro Conduction Mapping of Cardiac Action Potential.
abstract: 16-Channel organic electrochemical transistor arrays (OECTs) are developed for mapping the propagation and studying the characteristics of action potentials of primary cardiomyocytes. The physiological activities of a rat cardiomyocyte monolayer during a long-term culturing is revealed by this biocompatible, low-cost, and high transconductance organic electronic device. OECT has great potential to be used in cardiac and neuronal drug screening.
authors.affiliation: Bioengineering Graduate Program, Division of Biomedical Engineering, The Hong Kong University of Scienceand Technology, Hong Kong, China, 999077.
authors.forename: Xi
authors.initials: X
authors.lastname: Gu
authors.affiliation: Bioengineering Graduate Program, Division of Biomedical Engineering, The Hong Kong University of Scienceand Technology, Hong Kong, China, 999077.
authors.forename: Chunlei
authors.initials: C
authors.lastname: Yao
authors.affiliation: Bioengineering Graduate Program, Division of Biomedical Engineering, The Hong Kong University of Scienceand Technology, Hong Kong, China, 999077.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Bioengineering Graduate Program, Division of Biomedical Engineering, The Hong Kong University of Scienceand Technology, Hong Kong, China, 999077. kehsing@ust.hk.
authors.forename: I-Ming
authors.initials: IM
authors.lastname: Hsing
mesh_terms: D000200:Action Potentials; D000818:Animals; D018929:Cell Culture Techniques; D002460:Cell Line; D004353:Drug Evaluation, Preclinical / Q000295:instrumentation / Q000379:methods; D055664:Electrochemical Techniques / Q000295:instrumentation / Q000379:methods; D006801:Humans; D032383:Myocytes, Cardiac / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014173:Transistors, Electronic
keywords: action potential; cardiomyocyte; organic electrochemical transistors