title: (Neuro)degenerated Mitochondria-ER contacts.
abstract: In the last years, a considerable amount of experimental evidence has highlighted the association between neurodegenerative disorders (NDD) and the biology of mitochondria-Endoplasmic Reticulum contacts (MERCs). In this review, we summarize the most recent findings on this topic. We underline that dysregulation of MERCs can contribute to the neurodegenerative process either by altering directly the functionality of neurons and their response to stress stimuli and metabolic shifts or by indirectly influencing the neuroinflammatory response that accompanies NDD. Our overview of the current literature suggest that defective MERCs could be a common determinant to the "hypergeneration" and "neurodegeneration" programs, leading respectively to tumours and NDD.
authors.affiliation: Department of Biomedical Sciences, University of Padova, Padova, Italy.
authors.forename: Agnese
authors.initials: A
authors.lastname: De Mario
authors.affiliation: Venetian Institute of Molecular Medicine, Via Orus 2, 35129, Padova, Italy; Department of Biology, University of Padova, Via U. Bassi 58B, 35121, Padova, Italy.
authors.forename: Rubén
authors.initials: R
authors.lastname: Quintana-Cabrera
authors.affiliation: Department of Cell Physiology and Metabolism University of Geneva, 1211, Geneva, Switzerland.
authors.forename: Denis
authors.initials: D
authors.lastname: Martinvalet
authors.affiliation: Venetian Institute of Molecular Medicine, Via Orus 2, 35129, Padova, Italy; Department of Biology, University of Padova, Via U. Bassi 58B, 35121, Padova, Italy. Electronic address: marta.giacomello@bio.unipd.it.
authors.forename: Marta
authors.initials: M
authors.lastname: Giacomello
mesh_terms: D000818:Animals; D004721:Endoplasmic Reticulum / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D046529:Microscopy, Electron, Transmission; D008928:Mitochondria / Q000378:metabolism* / Q000648:ultrastructure; D019636:Neurodegenerative Diseases / Q000378:metabolism*
keywords: Cancer; Endoplasmic reticulum; Inflammation; Mitochondria; Mitochondria-endoplasmic reticulum contacts; Neurodegenerative disorders