title: Sensitive and selective detection of prostate-specific antigen using a photonic crystal nanolaser.
abstract: The detection of low-concentration biomarkers is expected to facilitate the early diagnosis of severe diseases, including malignant tumors. Using photonic crystal nanolaser sensors, we detected prostate-specific antigen (PSA) from a concentration of 1 fM, which is difficult to detect by conventional enzyme-linked immunosorbent assay. The signal intensity and stability were improved by using a surfactant (i.e., ethanolamine). Even when a contaminant such as bovine serum albumin was mixed into the PSA sample, thereby increasing the concentration of the contaminant ten billion times, it was still possible to maintain a high level of detection.
authors.forename: Shoji
authors.initials: S
authors.lastname: Hachuda
authors.forename: Takumi
authors.initials: T
authors.lastname: Watanabe
authors.forename: Daichi
authors.initials: D
authors.lastname: Takahashi
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Baba
mesh_terms: D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007834:Lasers; D008297:Male; D036103:Nanotechnology; D055095:Optics and Photonics; D017785:Photons; D017430:Prostate-Specific Antigen / Q000032:analysis*; D012710:Serum Albumin, Bovine
chemical_list: D012710:Serum Albumin, Bovine; D017430:Prostate-Specific Antigen