title: Kinetically Controlled Chemoselective Cyclization Simplifies the Access to Cyclic and Branched Peptides.
abstract: A bis(2-sulfanylethyl)amido group reacts significantly faster with cysteinyl peptides when installed on the C-terminal end of a peptide in comparison with the side-chain of Asp and Glu. This property enabled the design of a kinetically controlled chemoselective peptide cyclization reaction, giving straightforward access to cyclic and branched peptides in one pot.
authors.affiliation: Université de Lille, CNRS, Institut Pasteur de Lille, UMR 8161 , F-59000 Lille, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Boll
authors.affiliation: Université de Lille, CNRS, Institut Pasteur de Lille, UMR 8161 , F-59000 Lille, France.
authors.forename: Hervé
authors.initials: H
authors.lastname: Drobecq
authors.affiliation: Université de Lille, CNRS, Institut Pasteur de Lille, UMR 8161 , F-59000 Lille, France.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Lissy
authors.affiliation: Université de Lille, CNRS, UMR 8576, UGSF, Unité de Glycobiologie Structurale et Fonctionnelle , F-59000 Lille, France.
authors.forename: François-Xavier
authors.initials: FX
authors.lastname: Cantrelle
authors.affiliation: Université de Lille, CNRS, Institut Pasteur de Lille, UMR 8161 , F-59000 Lille, France.
authors.forename: Oleg
authors.initials: O
authors.lastname: Melnyk