title: Immune memory in invertebrates.
abstract: Evidence for innate immune memory (or 'priming') in invertebrates has been accumulating over the last years. We here provide an in-depth review of the current state of evidence for immune memory in invertebrates, and in particular take a phylogenetic viewpoint. Invertebrates are a very heterogeneous group of animals and accordingly, evidence for the phenomenon of immune memory as well as the hypothesized molecular underpinnings differ largely for the diverse invertebrate taxa. The majority of research currently focuses on Arthropods, while evidence from many other groups of invertebrates is fragmentary or even lacking. We here concentrate on immune memory that is induced by pathogenic challenges, but also extent our view to a non-pathogenic context, i.e. allograft rejection, which can also show forms of memory and can inform us about general principles of specific self-nonself recognition. We discuss definitions of immune memory and a number of relevant aspects such as the type of antigens used, the route of exposure, and the kinetics of reactions following priming.
authors.affiliation: Institute of Science and Technology Austria, Am Campus 1, 3400 Klosterneuburg, Austria. Electronic address: barbara.milutinovic@ist.ac.at.
authors.forename: Barbara
authors.initials: B
authors.lastname: Milutinović
authors.affiliation: Institute for Evolution and Biodiversity, University of Münster, Hüfferstrasse 1, 48149 Münster, Germany. Electronic address: joachim.kurtz@uni-muenster.de.
authors.forename: Joachim
authors.initials: J
authors.lastname: Kurtz
mesh_terms: D000818:Animals; D001181:Arthropods / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007156:Immunologic Memory; D007448:Invertebrates / Q000276:immunology*; D018448:Models, Immunological; D010802:Phylogeny
keywords: Host-parasite; Immune memory; Immune priming; Innate immunity; Invertebrate