title: A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora.
abstract: OBJECTIVE
  Two randomized, intra-individual comparison studies were performed in healthy subjects to evaluate the skin moisturization and barrier restoration potential of a new topical panthenol-containing emollient (NTP-CE) (Study 1), and its effect on skin microflora (Study 2).
  
  
  METHODS
  In Study 1 (N = 23), two skin areas, one challenged with 0.5% sodium dodecyl sulfate (SDS) solution and one unchallenged, were treated with NTP-CE for 3 weeks. Transepidermal water loss (TEWL), skin hydration, and intercellular lipid lamellae (ICLL) organization were measured at regular intervals during the study. In Study 2 (N = 20), quantitative bacterial cultures were obtained over 6 h from a skin area undergoing wash stress with 10% SDS with subsequent single application of NTP-CE.
  
  
  RESULTS
  In Study 1, mean AUC for TEWL reduction from baseline was more pronounced with NTP-CE compared with control (-168.36 vs. -123.38 g/m2/h, p = 0.023). NTP-CE use was also associated with statistically significant improvements in stratum corneum hydration and an increase in mean ICLL length from baseline (day 22: 120.61 vs. 35.85 nm/1000 nm2, p < 0.001). In Study 2, NTP-CE use had no negative impact on bacterial viability.
  
  
  CONCLUSIONS
  NTP-CE use has favorable and lasting effects on barrier function and repair as well as skin hydration without negatively influencing bacterial viability.
authors.affiliation: a Bayer Consumer Care AG , Basel , Switzerland.
authors.forename: Hans
authors.initials: H
authors.lastname: Stettler
authors.affiliation: a Bayer Consumer Care AG , Basel , Switzerland.
authors.forename: Peter
authors.initials: P
authors.lastname: Kurka
authors.affiliation: b proDERM Institute for Applied Dermatological Research , Schenefeld/Hamburg , Germany.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Lunau
authors.affiliation: b proDERM Institute for Applied Dermatological Research , Schenefeld/Hamburg , Germany.
authors.forename: Caroline
authors.initials: C
authors.lastname: Manger
authors.affiliation: b proDERM Institute for Applied Dermatological Research , Schenefeld/Hamburg , Germany.
authors.forename: Arne
authors.initials: A
authors.lastname: Böhling
authors.affiliation: b proDERM Institute for Applied Dermatological Research , Schenefeld/Hamburg , Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Bielfeldt
authors.affiliation: b proDERM Institute for Applied Dermatological Research , Schenefeld/Hamburg , Germany.
authors.forename: Klaus-Peter
authors.initials: KP
authors.lastname: Wilhelm
authors.affiliation: c Microscopy Services Dähnhardt GmbH , Flintbek , Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Dähnhardt-Pfeiffer
authors.affiliation: c Microscopy Services Dähnhardt GmbH , Flintbek , Germany.
authors.forename: Dorothee
authors.initials: D
authors.lastname: Dähnhardt
authors.affiliation: d Dr. Brill + Partner GmbH Institute for Hygiene Und Microbiology , Hamburg , Germany.
authors.forename: Florian H H
authors.initials: FH
authors.lastname: Brill
authors.affiliation: a Bayer Consumer Care AG , Basel , Switzerland.
authors.forename: Holger
authors.initials: H
authors.lastname: Lenz
mesh_terms: D000287:Administration, Topical; D000328:Adult; D001834:Body Water / Q000378:metabolism; D004643:Emollients / Q000008:administration & dosage* / Q000494:pharmacology; D004817:Epidermis / Q000378:metabolism; D005260:Female; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010205:Pantothenic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D012867:Skin / Q000378:metabolism / Q000382:microbiology*; D012967:Sodium Dodecyl Sulfate; D014870:Water Loss, Insensible / Q000187:drug effects*; D055815:Young Adult
chemical_list: D004643:Emollients; D010205:Pantothenic Acid; C007288:dexpanthenol; D012967:Sodium Dodecyl Sulfate
keywords: Emollient; microbiome; moisturization; panthenol; randomized controlled study; repair; skin; skin barrier; topical