title: Advancing Drug Formulation Additives toward Precision Additives with Release Mediating Peptide Interlayer.
abstract: Amphiphilic drug formulation additives based on palmitic acid-modified poly(ethylene glycol) (Pal-PEG) are combined with a tailored drug binding peptide that is positioned at the hydrophobic-hydrophilic interface. The peptide originates from combinatorial selection and enables precise modulation of the drug release profiles. While Pal provides a cost-effective reservoir for drug storage, the PEG realizes solubility and shielding. The precision additives reach high payloads close to 1:1, rendering a photosensitizer water-soluble and providing adjustable drug activation kinetics by fine-tuning the peptide interface layer.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Wieczorek
authors.forename: André
authors.initials: A
authors.lastname: Dallmann
authors.affiliation: Soft Matter and Functional Materials, Helmholtz-Zentrum Berlin für Materialien und Energie , Hahn-Meitner-Platz 1, Berlin, Germany.
authors.forename: Zdravko
authors.initials: Z
authors.lastname: Kochovski
authors.forename: Hans G
authors.initials: HG
authors.lastname: Börner
mesh_terms: D000595:Amino Acid Sequence; D004339:Drug Compounding; D057927:Hydrophobic and Hydrophilic Interactions; D009842:Oligopeptides / Q000737:chemistry*; D019308:Palmitic Acid / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D012995:Solubility
chemical_list: D009842:Oligopeptides; D019308:Palmitic Acid; D011092:Polyethylene Glycols