title: Involvement of transcription factor Oct-1 in the regulation of JAK-STAT signaling pathway in cells of Burkitt lymphoma.
abstract: We studied the role of transcription factor Oct-1 in the regulation of expression of genes of the JAK-STAT signaling pathway in the Namalwa Burkitt's lymphoma cell line. Overexpression of Oct-1 isoforms (Oct-1A, Oct-1L, and Oct-1X) causes a decrease in the activity of four genes involved in the JAK-STAT signaling pathway-IFNAR2, STAT1, STAT2, and STAT4. As a result of our research, it was found that genes STAT2 and STAT4 are direct targets for Oct-1 protein.
authors.affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, Moscow, 119991, Russia. tanjnij86@mail.ru.
authors.forename: E V
authors.initials: EV
authors.lastname: Pankratova
authors.affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, Moscow, 119991, Russia.
authors.forename: A G
authors.initials: AG
authors.lastname: Stepchenko
authors.affiliation: Moscow State Pedagogical University, ul. Malaya Pirogovskaya 1, Moscow, 119992, Russia.
authors.forename: I D
authors.initials: ID
authors.lastname: Krylova
authors.affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, Moscow, 119991, Russia.
authors.forename: T N
authors.initials: TN
authors.lastname: Portseva
authors.affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, Moscow, 119991, Russia.
authors.forename: S G
authors.initials: SG
authors.lastname: Georgieva
mesh_terms: D002051:Burkitt Lymphoma / Q000378:metabolism*; D045744:Cell Line, Tumor; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D050810:Octamer Transcription Factors / Q000378:metabolism*; D020033:Protein Isoforms; D012333:RNA, Messenger / Q000378:metabolism; D060888:Real-Time Polymerase Chain Reaction; D053633:Receptor, Interferon alpha-beta / Q000378:metabolism*; D050794:STAT1 Transcription Factor / Q000378:metabolism*; D050795:STAT2 Transcription Factor / Q000378:metabolism*; D050797:STAT4 Transcription Factor / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: C508033:IFNAR2 protein, human; D050810:Octamer Transcription Factors; C484169:POU2F3 protein, human; D020033:Protein Isoforms; D012333:RNA, Messenger; D050794:STAT1 Transcription Factor; C494079:STAT1 protein, human; D050795:STAT2 Transcription Factor; C494084:STAT2 protein, human; D050797:STAT4 Transcription Factor; C494090:STAT4 protein, human; D053633:Receptor, Interferon alpha-beta