title: [Identification and quantitative determination of baclofen in human blood by HPLC with mass spectrometry detection].
abstract: A method of identification and quantitative determination of baclofen in blood by HPLC with mass spectrometry detection has been developed. It is characterized by high sensitivity, specificity, linearity, accuracy, reproducibility, and a low detection for quantitative determination. The method has been used for diagnostics of acute baclofen poisoning in patients.
authors.affiliation: Siberian Federal University, Krasnoyarsk, Russia; Krasnoyarsk Regional Bureau of Forensic Medical Expertise, Krasnoyarsk, Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Dukova
authors.affiliation: Central Research Laboratory Voyno-Yasenetsky Krasnoyarsk Medical University, Krasnoyarsk, Russia.
authors.forename: M Yu
authors.initials: MY
authors.lastname: Kotlovsky
authors.affiliation: Siberian Federal University, Krasnoyarsk, Russia; Central Research Laboratory Voyno-Yasenetsky Krasnoyarsk Medical University, Krasnoyarsk, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Pokrovsky
authors.affiliation: Krasnoyarsk Regional Bureau of Forensic Medical Expertise, Krasnoyarsk, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Suvorova
authors.affiliation: Karpovich Municipal Clinical Emergency Hospital № 6., Krasnoyarsk, Russia.
authors.forename: T G
authors.initials: TG
authors.lastname: Shivrina
authors.affiliation: Siberian Medical University, Tomsk, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Krasnov
authors.affiliation: Siberian Federal University, Krasnoyarsk, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Efremov
mesh_terms: D001418:Baclofen / Q000097:blood* / Q000506:poisoning; D001774:Blood Chemical Analysis / Q000379:methods*; D016022:Case-Control Studies; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods; D009125:Muscle Relaxants, Central / Q000097:blood* / Q000506:poisoning; D012680:Sensitivity and Specificity
chemical_list: D009125:Muscle Relaxants, Central; D001418:Baclofen
keywords: HPLC-MS/MS; baclofen; diagnostics; poisoning