title: Fanconi syndrome induced by tenofovir: A case report.
abstract: Tenofovir disoproxil fumarate (TDF) is a nucleotide reverse transcriptase inhibitor discovered in the USA in 2001. It is currently the treatment of choice for patients co-infected with human immunodeficiency virus (HIV) and hepatitis B virus. Its antiretroviral efficacy and good tolerance are responsible for the higher frequency of prescriptions compared with other nucleoside analogs. However, it can induce acute renal toxicity causing impairment of the proximal tubular function of the kidney. This is highly dependent on factors such as associated co-prescription didanosine or a protease inhibitor "boosted" with ritonavir, preexisting renal insufficiency, low body weight, or presence of associated diabetes. In contrast, long-term renal toxicity remains highly debated. Some studies describe a decrease in estimated glomerular filtration rate during prolonged treatment with TDF. Others reported renal safety even during prolonged use. The differences between patients enrolled in the different studies, the measured parameters and their interpretation could explain these discrepancies. We describe a case of a patient infected with HIV, who presented with Fanconi syndrome with acute renal failure six months after starting antiretroviral treatment including tenofovir.
authors.affiliation: Department of Nephrology, Hemodialysis and Transplantation, Ibn Rochd University Hospital, Casablanca, Morocco.
authors.forename: Bouchra
authors.initials: B
authors.lastname: Lify
authors.affiliation: Department of Infectious Diseases, Ibn Rochd University Hospital, Casablanca, Morocco.
authors.forename: G
authors.initials: G
authors.lastname: Dabo
authors.affiliation: Department of Nephrology, Hemodialysis and Transplantation, Ibn Rochd University Hospital, Casablanca, Morocco.
authors.forename: O
authors.initials: O
authors.lastname: Nascimento
authors.affiliation: Department of Nephrology, Hemodialysis and Transplantation, Ibn Rochd University Hospital, Casablanca, Morocco.
authors.forename: S
authors.initials: S
authors.lastname: Iraqui
authors.affiliation: Department of Nephrology, Hemodialysis and Transplantation, Ibn Rochd University Hospital, Casablanca, Morocco.
authors.forename: S
authors.initials: S
authors.lastname: Elkhayat
authors.affiliation: Department of Nephrology, Hemodialysis and Transplantation, Ibn Rochd University Hospital, Casablanca, Morocco.
authors.forename: M
authors.initials: M
authors.lastname: Zamd
authors.affiliation: Department of Nephrology, Hemodialysis and Transplantation, Ibn Rochd University Hospital, Casablanca, Morocco.
authors.forename: G
authors.initials: G
authors.lastname: Medkouri
authors.affiliation: Department of Nephrology, Hemodialysis and Transplantation, Ibn Rochd University Hospital, Casablanca, Morocco.
authors.forename: M
authors.initials: M
authors.lastname: Benghanem
authors.affiliation: Department of Nephrology, Hemodialysis and Transplantation, Ibn Rochd University Hospital, Casablanca, Morocco.
authors.forename: B
authors.initials: B
authors.lastname: Ramdani
authors.affiliation: Department of Infectious Diseases, Ibn Rochd University Hospital, Casablanca, Morocco.
authors.forename: M M
authors.initials: MM
authors.lastname: Sodqi
authors.affiliation: Department of Infectious Diseases, Ibn Rochd University Hospital, Casablanca, Morocco.
authors.forename: L
authors.initials: L
authors.lastname: Marih
authors.affiliation: Department of Infectious Diseases, Ibn Rochd University Hospital, Casablanca, Morocco.
authors.forename: A
authors.initials: A
authors.lastname: Chakib
authors.affiliation: Department of Infectious Diseases, Ibn Rochd University Hospital, Casablanca, Morocco.
authors.forename: K
authors.initials: K
authors.lastname: El FilaliMarhoum
mesh_terms: D000225:Adenine; D019380:Anti-HIV Agents; D005198:Fanconi Syndrome; D015658:HIV Infections; D006801:Humans; D063065:Organophosphonates; D018894:Reverse Transcriptase Inhibitors; D000068698:Tenofovir
chemical_list: D019380:Anti-HIV Agents; D063065:Organophosphonates; D018894:Reverse Transcriptase Inhibitors; D000068698:Tenofovir; D000225:Adenine