title: Dietary fat intake and endometrial cancer risk: A dose response meta-analysis.
abstract: Since body fatness is a convincing risk factor for endometrial cancer, dietary fat intake was speculated to be associated with endometrial cancer risk. However, epidemiological studies are inconclusive. We aimed to conduct a meta-analysis to assess the associations between dietary fat intake and endometrial cancer risk. We searched the PubMed, Embase, and Web of science databases updated to September 2015. In total, 7 cohort and 14 case-control studies were included. Pooled analysis of case-control studies suggested that endometrial cancer risk was significantly increased by 5% per 10% kilocalories from total fat intake (P=0.02) and by 17% per 10 g/1000 kcal of saturated fat intake (P < 0.001). Summary of 3 cohort studies showed significant inverse association between monounsaturated fatty acids and endometrial cancer risk (odds ratio = 0.84, 95% confidence interval = 0.73-0.98) with a total of 524583 participants and 3503 incident cases. No significant associations were found for polyunsaturated fatty acids and linoleic acid. In conclusion, positive associations with endometrial cancer risk were observed for total fat and saturated fat intake in the case-control studies. Results from the cohort studies suggested higher monounsaturated fatty acids intake was significantly associated with lower endometrial cancer risk.
authors.affiliation: Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China Department of Applied Health Science, School of Public Health, Indiana University Bloomington, Bloomington, IN Department of Nutrition, Zhongshan Hospital Institute of Biostatistics Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.forename: Chen
authors.initials: C
authors.lastname: Lyu
authors.forename: Jian
authors.initials: J
authors.lastname: Gao
authors.forename: Li
authors.initials: L
authors.lastname: Du
authors.forename: Boer
authors.initials: B
authors.lastname: Shan
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Hua-Ying
authors.initials: HY
authors.lastname: Wang
authors.forename: Ying
authors.initials: Y
authors.lastname: Gao
mesh_terms: D016022:Case-Control Studies; D004041:Dietary Fats / Q000008:administration & dosage*; D016889:Endometrial Neoplasms / Q000453:epidemiology*; D005229:Fatty Acids, Monounsaturated / Q000008:administration & dosage*; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D019787:Linoleic Acid / Q000008:administration & dosage*; D012306:Risk
chemical_list: D004041:Dietary Fats; D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated; D019787:Linoleic Acid