title: Immune Regulation and Antitumor Effect of TIM-1.
abstract: T cells play an important role in antitumor immunity, and the T cell immunoglobulin domain and the mucin domain protein-1 (TIM-1) on its surface, as a costimulatory molecule, has a strong regulatory effect on T cells. TIM-1 can regulate and enhance type 1 immune response of tumor association. Therefore, TIM-1 costimulatory pathways may be a promising therapeutic target in future tumor immunotherapy. This review describes the immune regulation and antitumor effect of TIM-1.
authors.affiliation: Department of Tumor Biological Treatment, The Third Affiliated Hospital, Soochow University, Changzhou, Jiangsu 213003, China; Jiangsu Engineering Research Center for Tumor Immunotherapy, Changzhou, Jiangsu 213003, China; The Second People's Hospital of Gansu Province, Lanzhou, Gansu 730000, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Du
authors.affiliation: Department of Tumor Biological Treatment, The Third Affiliated Hospital, Soochow University, Changzhou, Jiangsu 213003, China; Jiangsu Engineering Research Center for Tumor Immunotherapy, Changzhou, Jiangsu 213003, China; Department of Oncology, The 181st Hospital of PLA, Guilin, Guangxi 541002, China.
authors.forename: Ruihua
authors.initials: R
authors.lastname: Xiong
authors.affiliation: Department of Tumor Biological Treatment, The Third Affiliated Hospital, Soochow University, Changzhou, Jiangsu 213003, China; Jiangsu Engineering Research Center for Tumor Immunotherapy, Changzhou, Jiangsu 213003, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Tumor Biological Treatment, The Third Affiliated Hospital, Soochow University, Changzhou, Jiangsu 213003, China; Jiangsu Engineering Research Center for Tumor Immunotherapy, Changzhou, Jiangsu 213003, China.
authors.forename: Jingting
authors.initials: J
authors.lastname: Jiang
mesh_terms: D000818:Animals; D015972:Gene Expression Regulation, Neoplastic; D000072596:Hepatitis A Virus Cellular Receptor 1 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007107:Immune System / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D056747:Immunomodulation; D009369:Neoplasms / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D011485:Protein Binding; D054730:Protein Interaction Domains and Motifs; D015398:Signal Transduction; D013329:Structure-Activity Relationship; D059016:Tumor Microenvironment / Q000235:genetics / Q000276:immunology
chemical_list: C491143:HAVCR1 protein, human; D000072596:Hepatitis A Virus Cellular Receptor 1