title: Emerging Technologies for Gut Microbiome Research.
abstract: Understanding the importance of the gut microbiome on modulation of host health has become a subject of great interest for researchers across disciplines. As an intrinsically multidisciplinary field, microbiome research has been able to reap the benefits of technological advancements in systems and synthetic biology, biomaterials engineering, and traditional microbiology. Gut microbiome research has been revolutionized by high-throughput sequencing technology, permitting compositional and functional analyses that were previously an unrealistic undertaking. Emerging technologies, including engineered organoids derived from human stem cells, high-throughput culturing, and microfluidics assays allowing for the introduction of novel approaches, will improve the efficiency and quality of microbiome research. Here, we discuss emerging technologies and their potential impact on gut microbiome studies.
authors.affiliation: Department of Cell Biology and Physiology, and Microbiome Core Facility, School of Medicine, University of North Carolina, Chapel Hill, NC, USA.
authors.forename: Jason W
authors.initials: JW
authors.lastname: Arnold
authors.affiliation: Research Computing, University of North Carolina, Chapel Hill, NC, USA.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Roach
authors.affiliation: Department of Cell Biology and Physiology, and Microbiome Core Facility, School of Medicine, University of North Carolina, Chapel Hill, NC, USA. Electronic address: azcarate@med.unc.edu.
authors.forename: M Andrea
authors.initials: MA
authors.lastname: Azcarate-Peril
mesh_terms: D001672:Biocompatible Materials; D057005:Bioengineering; D018929:Cell Culture Techniques; D019295:Computational Biology; D000069196:Gastrointestinal Microbiome; D006262:Health; D057166:High-Throughput Screening Assays; D006801:Humans; D055432:Metabolomics; D008828:Microbiological Techniques; D012106:Research; D013234:Stem Cells
chemical_list: D001672:Biocompatible Materials
keywords: automated culturing; gut microbiome; high-throughput sequencing; microbial cultivation; personalized medicine