title: Matched and mixed cap derivatives in the tetracyclic indole class of HCV NS5A inhibitors.
abstract: A matched and mixed capping SAR study was conducted on the tetracyclic indole class of HCV NS5A inhibitors to examine the influence of modifications of this region on the overall HCV virologic resistance profiles.
authors.affiliation: Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA. Electronic address: michael.dwyer@merck.com.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Dwyer
authors.affiliation: Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA.
authors.forename: Kerry M
authors.initials: KM
authors.lastname: Keertikar
authors.affiliation: Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA.
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
authors.affiliation: Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA.
authors.forename: Ling
authors.initials: L
authors.lastname: Tong
authors.affiliation: Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA.
authors.forename: Oleg
authors.initials: O
authors.lastname: Selyutin
authors.affiliation: Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA.
authors.forename: Anilkumar G
authors.initials: AG
authors.lastname: Nair
authors.affiliation: Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA.
authors.forename: Wensheng
authors.initials: W
authors.lastname: Yu
authors.affiliation: Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA.
authors.forename: Guowei
authors.initials: G
authors.lastname: Zhou
authors.affiliation: Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA.
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Lavey
authors.affiliation: Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA.
authors.forename: De-Yi
authors.initials: DY
authors.lastname: Yang
authors.affiliation: Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Wong
authors.affiliation: Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA.
authors.forename: Seong Heon
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA.
authors.forename: Craig A
authors.initials: CA
authors.lastname: Coburn
authors.affiliation: Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA.
authors.forename: Stuart B
authors.initials: SB
authors.lastname: Rosenblum
authors.affiliation: Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA.
authors.forename: Qingbei
authors.initials: Q
authors.lastname: Zeng
authors.affiliation: Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA.
authors.forename: Yueheng
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA.
authors.forename: Bandarpalle B
authors.initials: BB
authors.lastname: Shankar
authors.affiliation: Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA.
authors.forename: Razia
authors.initials: R
authors.lastname: Rizvi
authors.affiliation: Drug Metabolism, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA.
authors.forename: Amin A
authors.initials: AA
authors.lastname: Nomeir
authors.affiliation: Discovery Biology, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA.
authors.forename: Rong
authors.initials: R
authors.lastname: Liu
authors.affiliation: Discovery Biology, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA.
authors.forename: Sony
authors.initials: S
authors.lastname: Agrawal
authors.affiliation: Discovery Biology, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA.
authors.forename: Ellen
authors.initials: E
authors.lastname: Xia
authors.affiliation: Discovery Biology, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA.
authors.forename: Rong
authors.initials: R
authors.lastname: Kong
authors.affiliation: Discovery Biology, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhai
authors.affiliation: Discovery Biology, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Ingravallo
authors.affiliation: Discovery Biology, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA.
authors.forename: Ernest
authors.initials: E
authors.lastname: Asante-Appiah
authors.affiliation: Discovery Chemistry, Merck Research Laboratories, 2000 Galloping Hill Rd., Kenilworth, NJ 07033, USA.
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Kozlowski
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D019540:Area Under Curve; D005838:Genotype; D006207:Half-Life; D016174:Hepacivirus / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D007211:Indoles / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D012372:ROC Curve; D051381:Rats; D013329:Structure-Activity Relationship; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D012324:RNA-Dependent RNA Polymerase
chemical_list: D000998:Antiviral Agents; D007211:Indoles; D017361:Viral Nonstructural Proteins; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase
keywords: Capping; Hepatitis C; Indole; Infectious diseases; NS5A