title: The relief of dry eye signs and symptoms using a combination of lubricants, lid hygiene and ocular nutraceuticals.
abstract: OBJECTIVE
  To determine the combined effect of TheraTears®Lubricant Eye Drops, TheraTears®SteriLid Eyelid Cleanser, and TheraTears®Nutrition on dry eye signs and symptoms.
  
  
  METHODS
  This prospective study enrolled 28 dry eye participants. Participants were instructed to use the Lubricant Eye Drops at least 2-4× a day, SteriLid 1-2× a day, and Nutrition 3 gel caps once a day. Participants were followed up at baseline, 1 month and 3 months. Outcome variables were the Ocular Surface Disease Index (OSDI), Symptom Assessment iN Dry Eye (SANDE) questionnaire, non-invasive tear break-up time (NIBUT), osmolarity, number of meibomian glands blocked (#MG blocked), meibum quality, eyelid margin features, Schirmer's test, tear film lipid layer thickness (LLT), meniscus height, corneal and conjunctival staining.
  
  
  RESULTS
  Twenty participants (mean age=43, from 23 to 66, 17F, 3M) completed the study. Participants reported having used, on average, the Lubricant Eye Drop 2.4×/day, the SteriLid 1.1×/day, and the Nutrition 3 gel caps 1×/day. There was a significant change over time (p<0.05) for OSDI (-21.2 points), SANDE (-32.4 points), NIBUT (+0.43s), eyelid margin features (-1.1 grade), meibum quality (-1.0 grade), and #MG blocked (-4.0 glands).
  
  
  CONCLUSIONS
  By using a combination of TheraTears®Lubricant Eye Drop, SteriLid, and Nutrition, patients experience significant relief in both dry eye symptoms and signs.
authors.affiliation: Centre for Contact Lens Research, University of Waterloo School of Optometry & Vision Science, Waterloo, Ontario, Canada. Electronic address: wngo@uwaterloo.ca.
authors.forename: William
authors.initials: W
authors.lastname: Ngo
authors.affiliation: Centre for Contact Lens Research, University of Waterloo School of Optometry & Vision Science, Waterloo, Ontario, Canada.
authors.forename: Sruthi
authors.initials: S
authors.lastname: Srinivasan
authors.affiliation: Akorn, Inc., Ann Arbor, MI, USA.
authors.forename: Diane
authors.initials: D
authors.lastname: Houtman
authors.affiliation: Centre for Contact Lens Research, University of Waterloo School of Optometry & Vision Science, Waterloo, Ontario, Canada.
authors.forename: Lyndon
authors.initials: L
authors.lastname: Jones
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D003228:Conjunctiva / Q000473:pathology; D003315:Cornea / Q000473:pathology; D019587:Dietary Supplements; D015352:Dry Eye Syndromes / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D006920:Hygiene; D065346:Lubricant Eye Drops / Q000627:therapeutic use*; D008297:Male; D008537:Meibomian Glands / Q000503:physiopathology; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000627:therapeutic use*; D011446:Prospective Studies; D011795:Surveys and Questionnaires; D013666:Tears / Q000378:metabolism; D055815:Young Adult
chemical_list: D065346:Lubricant Eye Drops; D009883:Ophthalmic Solutions
keywords: Dry eye; Nutraceutical; Nutracéuticos; Nutrición; Nutrition; Ojo seco; SteriLid; TheraTears