title: Differential effect of treadmill exercise on histone deacetylase activity in rat striatum at different stages of development.
abstract: The study described herein aimed to evaluate the impact of exercise on histone acetylation markers in striatum from Wistar rats at different stages of development. Male Wistar rats were submitted to two different exercise protocols: a single session of treadmill (running 20 min) or a moderate daily exercise protocol (running 20 min for 2 weeks). Striata of rats aged 39 days postnatal (adolescents), 3 months (young adults), and 20 months (aged) were used. The single exercise session induced persistent effects on global HDAC activity only in the adolescent group, given that exercised rats showed decreased HDAC activity 1 and 18 h after training, without effect on histone H4 acetylation levels. However, the moderate daily exercise did not alter any histone acetylation marker in adolescent and mature groups in any time point evaluated after training. In sum, our data suggest that exercise impacts striatal HDAC activity in an age- and protocol-dependent manner. Specifically, this response seems to be more evident during the adolescent period and might suffer a molecular adaptation in response to chronic training.
authors.affiliation: Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul , Porto Alegre, Rio Grande do Sul, Brasil.|Programa de Pós Graduação em Biociências e Reabilitação, Centro Universitário Metodista-IPA, Porto Alegre, Rio Grande do Sul, Brasil.
authors.forename: Viviane Rostirola
authors.initials: VR
authors.lastname: Elsner
authors.affiliation: Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul , Porto Alegre, Rio Grande do Sul, Brasil.
authors.forename: Carla
authors.initials: C
authors.lastname: Basso
authors.affiliation: Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul , Porto Alegre, Rio Grande do Sul, Brasil.
authors.forename: Karine
authors.initials: K
authors.lastname: Bertoldi
authors.affiliation: Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul , Porto Alegre, Rio Grande do Sul, Brasil.
authors.forename: Louisiana Carolina Ferreira
authors.initials: LC
authors.lastname: de Meireles
authors.affiliation: Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul , Porto Alegre, Rio Grande do Sul, Brasil.
authors.forename: Laura Reck
authors.initials: LR
authors.lastname: Cechinel
authors.affiliation: Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul , Porto Alegre, Rio Grande do Sul, Brasil. ionara@ufrgs.br.|Laboratório de Neuropsicofarmacologia, Departamento de Farmacologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brasil. ionara@ufrgs.br.
authors.forename: Ionara Rodrigues
authors.initials: IR
authors.lastname: Siqueira
mesh_terms: D000107:Acetylation; D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism* / Q000502:physiology*; D005080:Exercise Test / Q000379:methods; D006624:Hippocampus / Q000378:metabolism / Q000502:physiology; D006655:Histone Deacetylases / Q000378:metabolism*; D008297:Male; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D006655:Histone Deacetylases
keywords: Forced exercise; Histone deacetylases; Stage of development; Striatum; Wistar rats