title: Cytoskeletal Regulation of Inflammation and Its Impact on Skin Blistering Disease Epidermolysis Bullosa Acquisita.
abstract: Actin remodelling proteins regulate cytoskeletal cell responses and are important in both innate and adaptive immunity. These responses play a major role in providing a fine balance in a cascade of biological events that results in either protective acute inflammation or chronic inflammation that leads to a host of diseases including autoimmune inflammation mediated epidermolysis bullosa acquisita (EBA). This review describes the role of the actin cytoskeleton and in particular the actin remodelling protein called Flightless I (Flii) in regulating cellular inflammatory responses and its subsequent effect on the autoimmune skin blistering disease EBA. It also outlines the potential of an antibody based therapy for decreasing Flii expression in vivo to ameliorate the symptoms associated with EBA.
authors.affiliation: Future Industries Institute, Regenerative Medicine, University of South Australia, Mawson Lakes 5095, Adelaide, Australia. zlatko.kopecki@unisa.edu.au.
authors.forename: Zlatko
authors.initials: Z
authors.lastname: Kopecki
authors.affiliation: Institute of Experimental Dermatology, University of Lubeck, Lubeck 23562, Germany. Ralf.Ludwig@uksh.de.
authors.forename: Ralf J
authors.initials: RJ
authors.lastname: Ludwig
authors.affiliation: Future Industries Institute, Regenerative Medicine, University of South Australia, Mawson Lakes 5095, Adelaide, Australia. allison.cowin@unisa.edu.au.
authors.forename: Allison J
authors.initials: AJ
authors.lastname: Cowin
mesh_terms: D000818:Animals; D003599:Cytoskeleton / Q000502:physiology*; D016107:Epidermolysis Bullosa Acquisita / Q000453:epidemiology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D012871:Skin Diseases / Q000453:epidemiology*
keywords: actin cytoskeleton; epidermolysis bullosa acquisita; inflammation; skin blistering