title: Rheumatic Disease Autoantibodies in Autoimmune Liver Diseases.
abstract: BACKGROUND
  Autoimmune liver diseases (ALDs) are known to be associated with systemic autoimmune rheumatic diseases (SARDs) and their autoantibodies. We aimed to study the prevalence of SARDs and related autoantibodies, as well as their prognostic implications in a group of patients with ALDs.
  
  
  METHODS
  This was a cross-sectional study. Sixty patients with ALDs (38.3% with autoimmune hepatitis; 11.7% with primary biliary cirrhosis; 25% with primary sclerosing cholangitis and 25% with overlap syndrome) were studied for the presence of SARDs and their autoantibodies.
  
  
  RESULTS
  There was autoimmune rheumatic disease in 20% of the studied sample. Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) were the commonest (11.6% and 5%, respectively). Antinuclear antibodies (ANAs) were present in 35% of the patients, followed by anti-Ro (20.0%); anti-nucleosome (18.3%); rheumatoid factor (10%) anti-CCP (8.3%); anti-RNP (8.3%); anti-ds-DNA (6.6%); anti-La (3.3%); anti-Sm (3.3%), anti-ribosomal P (3.3%). Anti-Ro (p = 0.0004), anti-La (p = 0.03), anti-RNP (p = 0.04) and anti-Sm (p = 0.03) were commonly found in patients with SARD, but not anti-DNA, anti-nucleosome and anti-ribosomal P. No differences were found in liver function tests regarding to the presence of autoantibodies.
  
  
  CONCLUSIONS
  There was a high prevalence of SARD and their autoantibodies in ALD patients. Anti-Ro, anti-La, anti-RNP and anti-Sm positivity points to an association with systemic autoimmune rheumatic diseases. The presence of autoantibodies was not related to liver function tests.
authors.affiliation: a Immunopathology Laboratory , Clinics Hospital of Federal University of Paraná , Curitiba , Paraná , Brazil.|b Department of Clinical Analysis , Federal University of Paraná , Curitiba , Paraná , Brazil.
authors.forename: Shirley R R
authors.initials: SR
authors.lastname: Utiyama
authors.affiliation: c Rheumatology Unit of Evangelic University Hospital , Curitiba , Paraná , Brazil.
authors.forename: Katiane B
authors.initials: KB
authors.lastname: Zenatti
authors.affiliation: c Rheumatology Unit of Evangelic University Hospital , Curitiba , Paraná , Brazil.
authors.forename: Heloisa A J
authors.initials: HA
authors.lastname: Nóbrega
authors.affiliation: a Immunopathology Laboratory , Clinics Hospital of Federal University of Paraná , Curitiba , Paraná , Brazil.
authors.forename: Juliana Z C
authors.initials: JZ
authors.lastname: Soares
authors.affiliation: c Rheumatology Unit of Evangelic University Hospital , Curitiba , Paraná , Brazil.
authors.forename: Thelma L
authors.initials: TL
authors.lastname: Skare
authors.affiliation: a Immunopathology Laboratory , Clinics Hospital of Federal University of Paraná , Curitiba , Paraná , Brazil.
authors.forename: Caroline
authors.initials: C
authors.lastname: Matsubara
authors.affiliation: d Hepatology Unit , Clinics Hospital of Federal University of Paraná , Curitiba , Paraná , Brazil.
authors.forename: Dominique A
authors.initials: DA
authors.lastname: Muzzilo
authors.affiliation: a Immunopathology Laboratory , Clinics Hospital of Federal University of Paraná , Curitiba , Paraná , Brazil.|e Department of Medicine , Positivo University , Curitiba , Paraná , Brazil.
authors.forename: Renato M
authors.initials: RM
authors.lastname: Nisihara
mesh_terms: D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000097:blood*; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D001324:Autoantigens / Q000097:blood / Q000276:immunology; D015209:Cholangitis, Sclerosing / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D003430:Cross-Sectional Studies; D005260:Female; D019693:Hepatitis, Autoimmune / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D006801:Humans; D008099:Liver / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D008105:Liver Cirrhosis, Biliary / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D008111:Liver Function Tests; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D008945:Mitral Valve Prolapse / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D009216:Myopia / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D012217:Rheumatoid Factor / Q000097:blood*; D012871:Skin Diseases / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000276:immunology*
chemical_list: D000974:Antibodies, Antinuclear; D001324:Autoantigens; D012217:Rheumatoid Factor
keywords: Autoantibodies; autoimmunity; liver disease; rheumatic