title: Cognitive Dysfunction in Obsessive-Compulsive Disorder.
abstract: Obsessive-compulsive disorder (OCD) is a mental disorder featuring obsessions (intrusive thoughts) and compulsions (repetitive behaviors performed in the context of rigid rituals). There is strong evidence for a neurobiological basis of this disorder, involving limbic cortical regions and related basal ganglion areas. However, more research is needed to lift the veil on the precise nature of that involvement and the way it drives the clinical expression of OCD. Altered cognitive functions may underlie the symptoms and thus draw a link between the clinical expression of the disorder and its neurobiological etiology. Our extensive review demonstrates that OCD patients do present a broad range of neuropsychological dysfunctions across all cognitive domains (memory, attention, flexibility, inhibition, verbal fluency, planning, decision-making), but some methodological issues temper this observation. Thus, future research should have a more integrative approach to cognitive functioning, gathering contributions of both experimental psychology and more fundamental neurosciences.
authors.affiliation: "Behaviour, Emotion, and Basal Ganglia" Team, Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S1127, Institut du Cerveau et de la Moelle épinière, ICM, 75013, Paris, France. nabil.benzina@inserm.fr.
authors.forename: Nabil
authors.initials: N
authors.lastname: Benzina
authors.affiliation: "Behaviour, Emotion, and Basal Ganglia" Team, Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S1127, Institut du Cerveau et de la Moelle épinière, ICM, 75013, Paris, France.|AP-HP, Service de Psychiatrie, DHU PePsy, Hôpital Henri Mondor, Université Paris-Est Créteil, INSERM U955, Fondation FondaMental, Créteil, France.
authors.forename: Luc
authors.initials: L
authors.lastname: Mallet
authors.affiliation: "Behaviour, Emotion, and Basal Ganglia" Team, Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S1127, Institut du Cerveau et de la Moelle épinière, ICM, 75013, Paris, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Burguière
authors.affiliation: "Behaviour, Emotion, and Basal Ganglia" Team, Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S1127, Institut du Cerveau et de la Moelle épinière, ICM, 75013, Paris, France.
authors.forename: Karim
authors.initials: K
authors.lastname: N'Diaye
authors.affiliation: AP-HP, Service de Psychiatrie, DHU PePsy, Hôpital Henri Mondor, Université Paris-Est Créteil, INSERM U955, Fondation FondaMental, Créteil, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Pelissolo
mesh_terms: D003071:Cognition / Q000502:physiology*; D060825:Cognitive Dysfunction / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D009483:Neuropsychological Tests; D009771:Obsessive-Compulsive Disorder / Q000150:complications / Q000523:psychology
keywords: Attention; Cognitive dysfunction; Memory; Neuropsychology; Obsessive-compulsive disorder