title: Paget Disease: A Potential Pitfall in PSMA PET for Prostate Cancer.
abstract: We present a case of an 81-year-old man with multifocal Paget disease found on bone scan that was performed for incidentally diagnosed prostate cancer. The subsequent Ga-PSMA (HBED-CC) PET scan also displayed increased uptake in the same distribution. Multiple known tumors display increased Ga-PSMA uptake due to neovasculature. We postulate that increased Ga-PSMA uptake within the pagetoid bone relates to neovascularity known to occur in Paget disease. Such pagetic uptake could result in false-positive studies for bone metastases, particularly in the setting of less typical Paget disease.
authors.affiliation: From the Nuclear Medicine Department, Royal Brisbane and Women's Hospital, Brisbane, Australia.
authors.forename: John Kenneth
authors.initials: JK
authors.lastname: Blazak
authors.forename: Paul
authors.initials: P
authors.lastname: Thomas
mesh_terms: D000369:Aged, 80 and over; D000954:Antigens, Surface / Q000378:metabolism; D001859:Bone Neoplasms / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D004492:Edetic Acid / Q000031:analogs & derivatives; D005710:Gallium Radioisotopes / Q000378:metabolism; D043425:Glutamate Carboxypeptidase II / Q000378:metabolism; D006801:Humans; D008297:Male; D010001:Osteitis Deformans / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography / Q000379:methods; D011471:Prostatic Neoplasms / Q000473:pathology*
chemical_list: D000954:Antigens, Surface; D005710:Gallium Radioisotopes; C075313:N,N'-bis(2-hydroxy-5-(ethylene-beta-carboxy)benzyl)ethylenediamine N,N'-diacetic acid; D004492:Edetic Acid; C473848:FOLH1 protein, human; D043425:Glutamate Carboxypeptidase II