title: Nuclear Receptor Regulation of Aquaporin-2 in the Kidney.
abstract: Aquaporin-2 (AQP2) is a vasopressin-regulated water channel responsible for regulating water reabsorption through the apical plasma membrane of the principal cells of renal collecting ducts. It has been found that dysregulation and dysfunction of AQP2 cause many disorders related to water balance in people and animals, including polyuria and dilutional hyponatremia. Classically, AQP2 mRNA and protein expression and its membrane translocation are regulated by systemic vasopressin involving short-term regulation of AQP2 trafficking to and from the apical plasma membrane and long-term regulation of the total amount of the AQP2 protein in the cell. Recently, increasing evidence has demonstrated that collecting duct AQP2 expression and membrane translocation are also under the control of many other local factors, especially nuclear receptors. Here, we briefly review the progress of studies in this area and discuss the role of nuclear receptors in the regulation of water reabsorption via affecting AQP2 expression and function.
authors.affiliation: Advanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China. zhangxy@dmu.edu.cn.|Department of Physiology, AstraZeneca-Shenzhen University Joint Institute of Nephrology, Shenzhen University Health Science Center, Shenzhen 518060, China. zhangxy@dmu.edu.cn.
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Zhang
authors.affiliation: Advanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China. wangbing_1999_1981@163.com.
authors.forename: Bing
authors.initials: B
authors.lastname: Wang
authors.affiliation: Advanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China. guanyf@dmu.edu.cn.|Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China. guanyf@dmu.edu.cn.
authors.forename: You-Fei
authors.initials: YF
authors.lastname: Guan
mesh_terms: D000818:Animals; D051399:Aquaporin 2 / Q000235:genetics / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism*; D007685:Kidney Tubules, Collecting / Q000378:metabolism; D047492:Peroxisome Proliferator-Activated Receptors / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D011965:Receptors, Glucocorticoid / Q000378:metabolism; D018161:Receptors, Mineralocorticoid / Q000378:metabolism; D014867:Water / Q000378:metabolism
chemical_list: D051399:Aquaporin 2; D047492:Peroxisome Proliferator-Activated Receptors; D018160:Receptors, Cytoplasmic and Nuclear; D011965:Receptors, Glucocorticoid; D018161:Receptors, Mineralocorticoid; D014867:Water
keywords: estrogen receptor (ER); farnesoid X receptor (FXR); liver X receptors (LXRs); peroxisome proliferator-activated receptors (PPARs); water channel