title: The FKBP5 polymorphism rs1360780 is associated with lower weight loss after bariatric surgery: 26 months of follow-up.
abstract: BACKGROUND
  Bariatric surgery is the most effective treatment choice for severe obesity. Recent literature indicates that FK506-binding protein 51 (FKBP51) could play a role in energy homeostasis, influencing adipogenesis and weight.
  
  
  OBJECTIVE
  To evaluate if the presence of the T allele of the FKBP5 SNP rs1360780, associated with increased FKBP51 expression, could influence weight loss after bariatric surgery.
  
  
  METHODS
  Hospital de Clínicas de Porto Alegre, Brazil.
  
  
  METHODS
  Forty-two patients awaiting bariatric surgery were included, and the presence of the FKBP5 rs1360780 polymorphism was evaluated. During the postoperative period, a 26-month follow-up of weight loss was performed (n = 42, 36, 35, 35, and 30, from the first to fifth postoperative evaluation, respectively; loss to follow-up: 28.6%).
  
  
  RESULTS
  Carriers of the T allele presented significantly lower weight loss compared with patients with the C/C genotype after the 12th to 14th month follow-up period. Differences in weight loss between genotypes ranged from 14.2% to 19.9% of excess weight loss (P = .045 and .004, respectively) and from 7.6% to 9.0% of total weight loss (P = .002 for both comparisons). Furthermore, carriers of the T allele also presented an earlier cessation of weight loss after surgery.
  
  
  CONCLUSIONS
  The presence of the T allele of the FKBP5 SNP rs1360780 was associated with weight loss after bariatric surgery. Bariatric surgery can interact with genes involved in metabolic regulation, leading to different weight loss outcomes.
authors.affiliation: Laboratory of Molecular Psychiatry, National Institute for Translational Medicine, CNPq/INCT-TM, Hospital de Clínicas de Porto Alegre (HCPA) and Programa de Pós-graduação em Psiquiatria e Ciências do Comportamento, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
authors.forename: Ingrid Borba
authors.initials: IB
authors.lastname: Hartmann
authors.affiliation: Translational Psychiatry Program, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston (UTHealth) Medical School, Houston, Texas.
authors.forename: Gabriel Rodrigo
authors.initials: GR
authors.lastname: Fries
authors.affiliation: Laboratory of Molecular Psychiatry, National Institute for Translational Medicine, CNPq/INCT-TM, Hospital de Clínicas de Porto Alegre (HCPA) and Programa de Pós-graduação em Psiquiatria e Ciências do Comportamento, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
authors.forename: Joana
authors.initials: J
authors.lastname: Bücker
authors.affiliation: Laboratory of Molecular Psychiatry, National Institute for Translational Medicine, CNPq/INCT-TM, Hospital de Clínicas de Porto Alegre (HCPA) and Programa de Pós-graduação em Psiquiatria e Ciências do Comportamento, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
authors.forename: Ellen
authors.initials: E
authors.lastname: Scotton
authors.affiliation: Addiction Unit, Hospital de Clínicas de Porto Alegre (HCPA) and Programa de Pós-graduação em Psiquiatria e Ciências do Comportamento, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
authors.forename: Lisia
authors.initials: L
authors.lastname: von Diemen
authors.affiliation: Laboratory of Molecular Psychiatry, National Institute for Translational Medicine, CNPq/INCT-TM, Hospital de Clínicas de Porto Alegre (HCPA) and Programa de Pós-graduação em Psiquiatria e Ciências do Comportamento, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil. Electronic address: mksantanna@gmail.com.
authors.forename: Marcia
authors.initials: M
authors.lastname: Kauer-Sant'Anna
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D005260:Female; D015390:Gastric Bypass; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000235:genetics / Q000601:surgery; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011446:Prospective Studies; D022021:Tacrolimus Binding Proteins / Q000235:genetics*; D015431:Weight Loss / Q000235:genetics*; D055815:Young Adult; D000099159:Tacrolimus Binding Protein 5
chemical_list: D022021:Tacrolimus Binding Proteins; D000099159:Tacrolimus Binding Protein 5
keywords: Bariatric surgery; FKBP5 SNP rs1360780; Obesity