title: Clinical Course After Cardioverter-Defibrillator Implantation: Chagasic Versus Ischemic Patients.
abstract: BACKGROUND
  The outcome of Chagas disease patients after receiving implantable cardioverter defibrillator (ICD) is still controversial.
  
  
  OBJECTIVE
  To compare clinical outcomes after ICD implantation in patients with chronic Chagas cardiomyopathy (CCC) and ischemic heart disease (IHD).
  
  
  METHODS
  Prospective study of a population of 153 patients receiving ICD (65 with CCC and 88 with IHD). The devices were implanted between 2003 and 2011. Survival rates and event-free survival were compared.
  
  
  RESULTS
  The groups were similar regarding sex, functional class and ejection fraction. Ischemic patients were, on average, 10 years older than CCC patients (p < 0.05). Patients with CCC had lower schooling and monthly income than IHD patients (p < 0.05). The number of appropriate therapies was 2.07 higher in CCC patients, who had a greater incidence of appropriate shock (p < 0.05). Annual mortality rate and electrical storm incidence were similar in both groups. There was no sudden death in CCC patients, and only one in IHD patients. Neither survival time (p = 0.720) nor event-free survival (p = 0.143) significantly differed between the groups.
  
  
  CONCLUSIONS
  CCC doubles the risk of receiving appropriate therapies as compared to IHD, showing the greater complexity of arrhythmias in Chagas patients.
authors.affiliation: Setor de Cardiologia, Hospital Universitário Walter Cantídio, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
authors.forename: Francisca Tatiana Moreira
authors.initials: FT
authors.lastname: Pereira
authors.affiliation: Setor de Cardiologia, Hospital Universitário Walter Cantídio, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
authors.forename: Eduardo Arrais
authors.initials: EA
authors.lastname: Rocha
authors.affiliation: Setor de Cardiologia, Hospital Universitário Walter Cantídio, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
authors.forename: Marcelo de Paula Martins
authors.initials: Mde P
authors.lastname: Monteiro
authors.affiliation: Setor de Cardiologia, Hospital Universitário Walter Cantídio, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
authors.forename: Neiberg de Alcantara
authors.initials: Nde A
authors.lastname: Lima
authors.affiliation: Setor de Cardiologia, Hospital Universitário Walter Cantídio, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
authors.forename: Carlos Roberto Martins
authors.initials: CR
authors.lastname: Rodrigues Sobrinho
authors.affiliation: Departamento de Saúde Comunitária, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
authors.forename: Roberto da Justa
authors.initials: Rda J
authors.lastname: Pires Neto
mesh_terms: D000328:Adult; D000368:Aged; D002598:Chagas Cardiomyopathy / Q000401:mortality / Q000628:therapy*; D015331:Cohort Studies; D017147:Defibrillators, Implantable / Q000706:statistics & numerical data*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000401:mortality / Q000628:therapy*; D011446:Prospective Studies; D015996:Survival Rate; D016896:Treatment Outcome