title: Clinically malignant exophytic lesions in the background of oral submucous fibrosis: report of five cases.
abstract: Oral submucous fibrosis (OSF), a common disease in South Asia, is a chronic disorder, and there is a lack of proper scientific understanding about many aspects of the disease. Carcinogenesis in the background of dense fibrosis is considered the most significant aspect of the disease that needs investigation, as the transformation rate is also remarkable compared with other oral potentially malignant disorders. Verrucous growths are a common finding in patients with OSF. We highlight a group of patients who presented with clinically malignant verrucous growths. However, despite the highly suspicious clinical appearance, there was no histologic evidence of invasion. This subgroup of patients with OSF and the inability of the lesion to invade the underlying corium need to be investigated.
authors.affiliation: Department of Oral Pathology, Faculty of Dental Sciences, University of Peradeniya, Sri Lanka.
authors.forename: Liyanaarachchige A H
authors.initials: LA
authors.lastname: Jayasinghe
authors.affiliation: Department of Oral Pathology, Faculty of Dental Sciences, University of Peradeniya, Sri Lanka.
authors.forename: Prasangi M
authors.initials: PM
authors.lastname: Peiris
authors.affiliation: Department of Oral Pathology, Faculty of Dental Sciences, University of Peradeniya, Sri Lanka.
authors.forename: Wanninayake M
authors.initials: WM
authors.lastname: Tilakaratne
authors.affiliation: Department of Oral Pathology, Faculty of Dental Sciences, University of Peradeniya, Sri Lanka.
authors.forename: Ajith M
authors.initials: AM
authors.lastname: Attygalla
authors.affiliation: Department of Oral Medicine and Periodontology, Faculty of Dental Sciences, University of Peradeniya, Sri Lanka.
authors.forename: Ruwan D
authors.initials: RD
authors.lastname: Jayasinghe
authors.affiliation: Department of Oral Medicine and Periodontology, Faculty of Dental Sciences, University of Peradeniya, Sri Lanka.
authors.forename: Mohaideen A M
authors.initials: MA
authors.lastname: Sitheeque
authors.affiliation: Department of Oral Pathology, Faculty of Dental Sciences, University of Peradeniya, Sri Lanka. Electronic address: samadarani@yahoo.com.
authors.forename: Bogahawatte S M S
authors.initials: BS
authors.lastname: Siriwardena
mesh_terms: D000328:Adult; D000368:Aged; D001114:Areca; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D006801:Humans; D008297:Male; D009062:Mouth Neoplasms / Q000473:pathology*; D009914:Oral Submucous Fibrosis / Q000473:pathology*; D011230:Precancerous Conditions / Q000473:pathology*