title: [Non-motor symptoms in Parkinson's disease patients].
abstract: Intoduction - Objetive Parkinson's disease (PD) is associated with motor and non-motor symptoms , and is progressively disabling. The objective of this study was to determine the frequency of occurrence of non- motor symptoms (NMS ) in PD patients in treatment, according to the evolutionary stage of the disease.
  
  
  METHODS
  We carried out a prospective observational descriptive study which included patients diagnosed with PD who were under treatment and consulted at Servicio de Neurología del Hospital Nacional de Clínicas. Patients were classified into two groups: 1) Patients with PD with less than 2 years of disease evolution - "Early evolutive stage group"; and 2) Patients with PD of 6 years of disease evolution or more - "Late evolutive stage group". The following scales were applied: UPDRS, NMSQuest and H&Y.
  
  
  RESULTS
  110 PD patients , 61 men ( 55%) and 49 women (44 % ) were studied , with an age of 70.0 ± 0.9 years. The late evolution group had significantly higher frequency of anxiety, falls by orthostatic hypotension , hallucinations, nausea - vomiting and double vision, with respect to the group of early evolution. Significant correlations were observed between NMS (PDNMS Quest) and the time evolution of the EP (r2 0.11) and the UPDRS (r20.36) scale.
  
  
  CONCLUSIONS
  all patients had some NMS being significantly more common in patients in the late evolutionary group.
authors.affiliation: Médica Neuróloga, Servicio y Cátedra de Neurología. Hospital Nacional de Clínicas de Córdoba. Universidad Nacional de Córdoba (UNC), Argentina.
authors.forename: Ana Belen
authors.initials: AB
authors.lastname: Sad
authors.affiliation: Profesor Consulto de Medicina. Servicio de Clínica Médica. Hospital Nacional de Clínicas de Córdoba. Universidad Nacional de Córdoba, Argentina.
authors.forename: Raul
authors.initials: R
authors.lastname: Breglia
authors.affiliation: Médico Neurólogo, Doctor en Medicina y Cirugía. Jefe de Servicio y Cátedra de Neurología. Hospital Nacional de Clínicas de Córdoba. Universidad Nacional de Córdoba, Argentina.
authors.forename: Carlos Federico
authors.initials: CF
authors.lastname: Buonanotte
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000473:pathology* / Q000503:physiopathology* / Q000523:psychology; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires; D013997:Time Factors