title: [CYP1A1 rs4646422 gene polymorphisms not correlated with male infertility in Chinese Han population].
abstract: OBJECTIVE
  To determine the correlation of the CYP1A1 (rs4646422) gene polymorphisms with male infertility in the Chinese Han population.
  
  
  METHODS
  Using the Mass ARRAY iPLEX GOLD technique, we conducted a case-control study on theCYPlA1 (rs4646422) gene polymorphisms in 636 infertile males aged 21-49 years (case group) and 442 normal healthy men aged 23-47 years (control group) of the Chinese Han population. We analyzed the genotypes and allele frequencies in the two groups ofsubjects with the SPSS 20.0 software.
  
  
  RESULTS
  Compared with the wild homozygous genotype GG, the heterozygous genotype AG (OR = 1.06, 95% CI 0.81-1.38) and homozygous genotype AA (OR = 1.11, 95% CI 0.56-2.21) showed no correlation with male infertility, nor did the mutant allele A (OR = 1.06, 95% CI 0.85-1.32) in comparison with the wild allele G.
  
  
  CONCLUSIONS
  The CYP1A1 (rs4646422) gene polymorphisms might not be correlated with male infertility in the Chinese Han population.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhou
authors.forename: Pei-ran
authors.initials: PR
authors.lastname: Zhu
authors.forename: Ming-chao
authors.initials: MC
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Wei-jun
authors.initials: WJ
authors.lastname: Jiang
authors.forename: Meng-xia
authors.initials: MX
authors.lastname: Ni
authors.forename: Shuai-mei
authors.initials: SM
authors.lastname: Liu
authors.forename: Qiu-yue
authors.initials: QY
authors.lastname: Wu
authors.forename: Wei-wei
authors.initials: WW
authors.lastname: Li
authors.forename: Hao-qin
authors.initials: HQ
authors.lastname: Xu
authors.forename: Xin-yi
authors.initials: XY
authors.lastname: Xia
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D002681:China; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006720:Homozygote; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D055815:Young Adult
chemical_list: C569463:CYP1A1 protein, human; D019363:Cytochrome P-450 CYP1A1