title: Antidepressant-Like Effects of Fractions Prepared from Danzhi-Xiaoyao-San Decoction in Rats with Chronic Unpredictable Mild Stress: Effects on Hypothalamic-Pituitary-Adrenal Axis, Arginine Vasopressin, and Neurotransmitters.
abstract: The aim of the present study was to investigate the antidepressant-like effects of two fractions, including petroleum ether soluble fraction (Fraction A, FA) and water-EtOH soluble fraction (Fraction B, FB) prepared from the Danzhi-xiaoyao-san (DZXYS) by using chronic unpredictable mild stress-induced depressive rat model. The results indicated that DZXYS could ameliorate the depression-like behavior in chronic stress model of rats. The inhibition of hyperactivity of HPA axis and the modulation of monoamine and amino acid neurotransmitters in the hippocampus may be the important mechanisms underlying the action of DZXYS antidepressant-like effect in chronically stressed rats.
authors.affiliation: Department of Basic Theory of Chinese Medicine, School of Preclinical Medicine, Guangzhou University of Chinese Medicine, 232 Waihuandong Road, Higher Education Mega Center, Panyu District, Guangzhou 510060, China.
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Wu
authors.affiliation: Department of Basic Theory of Chinese Medicine, School of Preclinical Medicine, Guangzhou University of Chinese Medicine, 232 Waihuandong Road, Higher Education Mega Center, Panyu District, Guangzhou 510060, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Basic Theory of Chinese Medicine, School of Preclinical Medicine, Guangzhou University of Chinese Medicine, 232 Waihuandong Road, Higher Education Mega Center, Panyu District, Guangzhou 510060, China.
authors.forename: Can
authors.identifier: 0000-0003-2267-8296
authors.initials: C
authors.lastname: Yan
authors.affiliation: Department of Basic Theory of Chinese Medicine, School of Preclinical Medicine, Guangzhou University of Chinese Medicine, 232 Waihuandong Road, Higher Education Mega Center, Panyu District, Guangzhou 510060, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Pan
authors.affiliation: Department of Pathophysiology, School of Preclinical Medicine, Guangzhou University of Chinese Medicine, 232 Waihuandong Road, Higher Education Mega Center, Panyu District, Guangzhou 510060, China.
authors.forename: Jun-Fang
authors.initials: JF
authors.lastname: Su
authors.affiliation: Department of Pathophysiology, School of Preclinical Medicine, Sun Yat-Sen University, 58 Zhongshan Er Road, Guangzhou 510080, China.
authors.forename: Wei-Kang
authors.initials: WK
authors.lastname: Wu