title: Insights into Borrelia miyamotoi infection from an untreated case demonstrating relapsing fever, monocytosis and a positive C6 Lyme serology.
abstract: We describe a patient from the United States with PCR- and serology-confirmed Borrelia miyamotoi infection who recovered without antibiotics. Our findings suggest that B. miyamotoi infection may cause relapsing fever, blood monocytosis and antibody reactivity to the C6 peptide. Further studies are required to better define the spectrum of clinical and laboratory findings for this emerging tick-transmitted infection.
authors.affiliation: Division of Infectious Diseases, New York Medical College, Valhalla, NY, 10595, USA.
authors.forename: Praveen
authors.initials: P
authors.lastname: Sudhindra
authors.affiliation: Department of Pathology, New York Medical College, Valhalla, NY, 10595, USA; Department of Pathology and Clinical Laboratories, Westchester Medical Center, Valhalla, NY, 10595, USA.
authors.forename: Guiqing
authors.initials: G
authors.lastname: Wang
authors.affiliation: Centers for Disease Control and Prevention, Fort Collins, CO, USA.
authors.forename: Martin E
authors.initials: ME
authors.lastname: Schriefer
authors.affiliation: Division of Infectious Diseases, New York Medical College, Valhalla, NY, 10595, USA.
authors.forename: Donna
authors.initials: D
authors.lastname: McKenna
authors.affiliation: Department of Pathology, New York Medical College, Valhalla, NY, 10595, USA; Department of Pathology and Clinical Laboratories, Westchester Medical Center, Valhalla, NY, 10595, USA.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhuge
authors.affiliation: Yale School of Public Health and Yale School of Medicine, Yale University, New Haven, CT, USA.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Krause
authors.affiliation: Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
authors.forename: Adriana R
authors.initials: AR
authors.lastname: Marques
authors.affiliation: Division of Infectious Diseases, New York Medical College, Valhalla, NY, 10595, USA. Electronic address: gwormser@nymc.edu.
authors.forename: Gary P
authors.initials: GP
authors.lastname: Wormser
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D001898:Borrelia / Q000276:immunology* / Q000302:isolation & purification*; D006801:Humans; D007964:Leukocytosis / Q000209:etiology*; D008297:Male; D009000:Monocytes / Q000473:pathology*; D016133:Polymerase Chain Reaction; D012061:Relapsing Fever / Q000175:diagnosis* / Q000473:pathology*; D012698:Serologic Tests; D014481:United States
chemical_list: D000907:Antibodies, Bacterial
keywords: Borrelia; Borrelia Miyamotoi; C6 serology; Lyme disease; Monocytosis; Relapsing fever