title: Sensitization to Food Additives in Patients with Allergy: A Study Based on Skin Test and Open Oral Challenge.
abstract: There has been a great increase in the consumption of various food additives in recent years. The purpose of this study was to identify the incidence of sensitization to food additives by using skin prick test in patients with allergy and to determine the concordance rate between positive skin tests and oral challenge in hypersensitivity to additives. This cross-sectional study included 125 (female 71, male 54) patients aged 2-76 years with allergy and 100 healthy individuals. Skin tests were performed in both patient and control groups with 25 fresh food additives. Among patients with allergy, 22.4% showed positive skin test at least to one of the applied materials. Skin test was negative to all tested food additives in control group. Oral food challenge was done in 28 patients with positive skin test, in whom 9 patients showed reaction to culprit (Concordance rate=32.1%). The present study suggested that about one-third of allergic patients with positive reaction to food additives showed positive oral challenge; it may be considered the potential utility of skin test to identify the role of food additives in patients with allergy.
authors.affiliation: Allergy Clinic of Ali-Asghar Hospital, Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran AND Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mozhgan
authors.initials: M
authors.lastname: Moghtaderi
authors.affiliation: Department of Pediatrics, College of Medicine, Islamic Azad University, Kazerun Branch, Kazerun, Iran.
authors.forename: Zinatosadat
authors.initials: Z
authors.lastname: Hejrati
authors.affiliation: Department of Pediatrics, College of Medicine, Islamic Azad University- Kazerun Branch, Kazerun, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Dehghani
authors.affiliation: Department of Pediatrics, College of Medicine, Islamic Azad University, Kazerun Branch, Kazerun, Iran.
authors.forename: Faranak
authors.initials: F
authors.lastname: Dehghani
authors.affiliation: Department of Pediatrics, College of Medicine, Islamic Azad University, Kazerun Branch, Kazerun, Iran.
authors.forename: Niloofar
authors.initials: N
authors.lastname: Kolahi
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D005503:Food Additives / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis* / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012882:Skin Tests
chemical_list: D005503:Food Additives
keywords: Allergy; Food additives; Skin test