title: Simultaneous determination of 16 brominated flame retardants in food and feed of animal origin by fast gas chromatography coupled to tandem mass spectrometry using atmospheric pressure chemical ionisation.
abstract: A gas chromatography tandem mass spectrometry method using atmospheric pressure chemical ionisation was developed for the monitoring of 16 brominated flame retardants (7 usually monitored polybromodiphenylethers (PBDEs) and BDE #209 and 8 additional emerging and novel BFRs) in food and feed of animal origin. The developed analytical method has decreased the run time by three compared to conventional strategies, using a 2.5m column length (5% phenyl stationary phase, 0.1mm i.d., 0.1μmf.t.), a pulsed split injection (1:5) with carrier gas helium flow rate at 0.48mLmin(-1) in one run of 20 min. For most BFRs, analytical data were compared with the current analytical strategy relying on GC/EI/HRMS (double sector, R=10000 at 10% valley). Performances in terms of sensitivity were found to meet the Commission recommendation (118/2014/EC) for nBFRs. GC/APCI/MS/MS represents a promising alternative for multi-BFRs analysis in complex matrices, in that it allows the monitoring of a wider list of contaminants in a single injection and a shorter run time.
authors.affiliation: LABoratoire d'Étude des Résidus et Contaminants dans les Aliments (LABERCA), USC INRA 1329, Oniris, LUNAM Université, BP 50707, 44307 Nantes Cedex 3, France. Electronic address: emmanuelle.bichon@oniris-nantes.fr.
authors.forename: E
authors.initials: E
authors.lastname: Bichon
authors.affiliation: LABoratoire d'Étude des Résidus et Contaminants dans les Aliments (LABERCA), USC INRA 1329, Oniris, LUNAM Université, BP 50707, 44307 Nantes Cedex 3, France.
authors.forename: I
authors.initials: I
authors.lastname: Guiffard
authors.affiliation: LABoratoire d'Étude des Résidus et Contaminants dans les Aliments (LABERCA), USC INRA 1329, Oniris, LUNAM Université, BP 50707, 44307 Nantes Cedex 3, France.
authors.forename: A
authors.initials: A
authors.lastname: Vénisseau
authors.affiliation: LABoratoire d'Étude des Résidus et Contaminants dans les Aliments (LABERCA), USC INRA 1329, Oniris, LUNAM Université, BP 50707, 44307 Nantes Cedex 3, France.
authors.forename: E
authors.initials: E
authors.lastname: Lesquin
authors.affiliation: LABoratoire d'Étude des Résidus et Contaminants dans les Aliments (LABERCA), USC INRA 1329, Oniris, LUNAM Université, BP 50707, 44307 Nantes Cedex 3, France.
authors.forename: V
authors.initials: V
authors.lastname: Vaccher
authors.affiliation: LABoratoire d'Étude des Résidus et Contaminants dans les Aliments (LABERCA), USC INRA 1329, Oniris, LUNAM Université, BP 50707, 44307 Nantes Cedex 3, France.
authors.forename: A
authors.initials: A
authors.lastname: Brosseaud
authors.affiliation: LABoratoire d'Étude des Résidus et Contaminants dans les Aliments (LABERCA), USC INRA 1329, Oniris, LUNAM Université, BP 50707, 44307 Nantes Cedex 3, France.
authors.forename: P
authors.initials: P
authors.lastname: Marchand
authors.affiliation: LABoratoire d'Étude des Résidus et Contaminants dans les Aliments (LABERCA), USC INRA 1329, Oniris, LUNAM Université, BP 50707, 44307 Nantes Cedex 3, France.
authors.forename: B
authors.initials: B
authors.lastname: Le Bizec
mesh_terms: D000821:Animal Feed / Q000032:analysis*; D000818:Animals; D001274:Atmospheric Pressure; D005411:Flame Retardants / Q000032:analysis* / Q000592:standards; D005504:Food Analysis; D008401:Gas Chromatography-Mass Spectrometry / Q000592:standards; D055768:Halogenated Diphenyl Ethers; D054879:Halogenation; D006371:Helium / Q000737:chemistry; D007477:Ions / Q000737:chemistry; D011786:Quality Control
chemical_list: D005411:Flame Retardants; D055768:Halogenated Diphenyl Ethers; D007477:Ions; D006371:Helium; C010902:decabromobiphenyl ether
keywords: APCI; Brominated flame retardants; Fast GC/MS; Multiresidue method