title: Electrospinning of Nanodiamond-Modified Polysaccharide Nanofibers with Physico-Mechanical Properties Close to Natural Skins.
abstract: Electrospinning of biopolymers has gained significant interest for the fabrication of fibrous mats for potential applications in tissue engineering, particularly for wound dressing and skin regeneration. In this study, for the first time, we report successful electrospinning of chitosan-based biopolymers containing bacterial cellulous (33 wt %) and medical grade nanodiamonds (MND) (3 nm; up to 3 wt %). Morphological studies by scanning electron microscopy showed that long and uniform fibers with controllable diameters from 80 to 170 nm were prepared. Introducing diamond nanoparticles facilitated the electrospinning process with a decrease in the size of fibers. Fourier transform infrared spectroscopy determined hydrogen bonding between the polymeric matrix and functional groups of MND. It was also found that beyond 1 wt % MND, percolation networks of nanoparticles were formed which affected the properties of the nanofibrous mats. Uniaxial tensile testing of the woven mats determined significant enhancement of the strength (from 13 MPa to 25 MP) by dispersion of 1 wt % MND. The hydrophilicity of the mats was also remarkably improved, which was favorable for cell attachment. The water vapor permeability was tailorable in the range of 342 to 423 µg·Pa(-1)·s(-1)·m(-1). The nanodiamond-modified mats are potentially suitable for wound healing applications.
authors.affiliation: Department of Materials Science and Engineering, Sharif University of Technology, Azadi Avenue, 14588 Tehran, Iran. mina_m1372@yahoo.com.
authors.forename: Mina
authors.initials: M
authors.lastname: Mahdavi
authors.affiliation: Department of Materials Science and Engineering, Sharif University of Technology, Azadi Avenue, 14588 Tehran, Iran. Nafiseh_Mahmoudi@mehr.sharif.ir.
authors.forename: Nafiseh
authors.initials: N
authors.lastname: Mahmoudi
authors.affiliation: Department of Materials Science and Engineering, Sharif University of Technology, Azadi Avenue, 14588 Tehran, Iran. fd_rezaieanaran@dena.sharif.ir.
authors.forename: Farzad
authors.initials: F
authors.lastname: Rezaie Anaran
authors.affiliation: Department of Materials Science and Engineering, Sharif University of Technology, Azadi Avenue, 14588 Tehran, Iran. simchi@sharif.edu.|Institute for Nanoscience and Nanotechnology, Sharif University of Technology, P.O. Box 11365-9466, Azadi Avenue, 14588 Tehran, Iran. simchi@sharif.edu.
authors.forename: Abdolreza
authors.initials: A
authors.lastname: Simchi
mesh_terms: D000818:Animals; D001458:Bandages; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000737:chemistry*; D002460:Cell Line; D048271:Chitosan / Q000737:chemistry; D008422:Materials Testing / Q000379:methods; D051379:Mice; D008855:Microscopy, Electron, Scanning / Q000379:methods; D058612:Nanodiamonds / Q000737:chemistry*; D057139:Nanofibers / Q000008:administration & dosage / Q000737:chemistry*; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry; D011134:Polysaccharides / Q000737:chemistry*; D012867:Skin / Q000187:drug effects*; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D013718:Tensile Strength; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds / Q000737:chemistry; D014945:Wound Healing / Q000187:drug effects
chemical_list: D001672:Biocompatible Materials; D058612:Nanodiamonds; D011134:Polysaccharides; D048271:Chitosan
keywords: bacterial cellulose; chitosan nanofiber; electrospinning; nanodiamond; wound dressing