title: GFRα2 prompts cell growth and chemoresistance through down-regulating tumor suppressor gene PTEN via Mir-17-5p in pancreatic cancer.
abstract: Nerve growth factors and their receptors have received an increasing attention in certain cancers since they play an important role in regulating tumorigenesis, biological process and metastasis. Here we aimed at characterizing a new function of one of the subtypes of growth factor receptors (GFR), GFRα2, in pancreatic cancer. In this study, we showed that GFRα2 was up-regulated in pancreatic adenocarcinoma and was positively correlated with tumor size and perineural invasion, which indicated that it may be associated with cell growth and apoptosis. Mechanically, we discovered that high GFRα2 expression level leads to PTEN inactivation via enhancing Mir-17-5p level.
authors.affiliation: Department of General Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Key Laboratory of Computational Biology, CAS-MPG, Partner Institute of Computational Biology (PICB), Shanghai Institute for Biological Science (SIBS), Chinese Academy of Sciences (CAS), Shanghai, China; Research Institute of Digestive Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Jiangning
authors.initials: J
authors.lastname: Gu
authors.affiliation: Department of Prophylactic Medicine, Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Di
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Research Institute of Digestive Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Jiaqiang
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of General Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Department of General Surgery, the Second Hospital of Zhejiang University, Zhejiang, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Key Laboratory of Computational Biology, CAS-MPG, Partner Institute of Computational Biology (PICB), Shanghai Institute for Biological Science (SIBS), Chinese Academy of Sciences (CAS), Shanghai, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of General Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Research Institute of Digestive Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Chen
authors.affiliation: Research Institute of Digestive Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Minmin
authors.initials: M
authors.lastname: Shi
authors.affiliation: Key Laboratory of Computational Biology, CAS-MPG, Partner Institute of Computational Biology (PICB), Shanghai Institute for Biological Science (SIBS), Chinese Academy of Sciences (CAS), Shanghai, China.
authors.forename: Xuelong
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Research Institute of Digestive Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Baiyong
authors.initials: B
authors.lastname: Shen
authors.affiliation: Department of General Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Research Institute of Digestive Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Xiaxing
authors.initials: X
authors.lastname: Deng
authors.affiliation: Department of General Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Research Institute of Digestive Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhan
authors.affiliation: Key Laboratory of Computational Biology, CAS-MPG, Partner Institute of Computational Biology (PICB), Shanghai Institute for Biological Science (SIBS), Chinese Academy of Sciences (CAS), Shanghai, China. Electronic address: weigang@picb.ac.cn.
authors.forename: Gang
authors.initials: G
authors.lastname: Wei
authors.affiliation: Department of General Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Research Institute of Digestive Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Electronic address: chhpeng@188.com.
authors.forename: Chenghong
authors.initials: C
authors.lastname: Peng
mesh_terms: D000818:Animals; D021441:Carcinoma, Pancreatic Ductal / Q000188:drug therapy / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003841:Deoxycytidine / Q000031:analogs & derivatives / Q000494:pharmacology; D019008:Drug Resistance, Neoplasm; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D051097:Glial Cell Line-Derived Neurotrophic Factor Receptors / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008819:Mice, Nude; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D051059:PTEN Phosphohydrolase / Q000235:genetics / Q000378:metabolism*; D010190:Pancreatic Neoplasms / Q000188:drug therapy / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D034622:RNA Interference; D015398:Signal Transduction; D013997:Time Factors; D014162:Transfection; D047368:Tumor Burden; D000093542:Gemcitabine
chemical_list: C494990:GFRA2 protein, human; D051097:Glial Cell Line-Derived Neurotrophic Factor Receptors; C524941:MIRN17 microRNA, human; D035683:MicroRNAs; D003841:Deoxycytidine; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human; D000093542:Gemcitabine
keywords: Chemoresistance; GFRα2; Mir-17-5p; PTEN; Pancreatic cancer