title: The Role of Platelet-Derived Growth Factor Receptor in Early Brain Injury Following Subarachnoid Hemorrhage.
abstract: OBJECTIVE
  This study aims to observe encephaledema and cell apoptosis in rats following subarachnoid hemorrhage (SAH) and to explore the mechanism of platelet-derived growth factor receptor (PDGFR) in the development of early brain injury (EBI).
  
  
  METHODS
  Adult and male Sprague-Dawley rats were randomly divided into 4 groups: sham operation, SAH, SAH + imatinib, and SAH + platelet-derived growth factor-BB (PDGF-BB). SAH model was established using intravascular silk puncture of the internal carotid artery crotch. The SAH + imatinib group was treated with intraperitoneal injection of imatinib 1 hour before establishing the model. The SAH + PDGF-BB group was administered with intracerebroventricular injection of PDGF-BB 1 hour before establishing the model. The mortality, encephaledema, and nerve functional scoring were observed after 24 hours in all groups. The expression of caspase-3 in hippocampus was tested by reverse transcription polymerase chain reaction and Western blotting.
  
  
  RESULTS
  Mortality and encephaledema were the highest in the SAH + PDGF-BB group, which were alleviated when the rats were injected with imatinib (P < .01).
  
  
  CONCLUSIONS
  PDGFR may participate in the pathogenesis of EBI following SAH. The antagonist of PDGFR, imatinib, can reduce brain damage to some degree.
authors.affiliation: Department of Neurosurgery, Yongchuan Hospital, Chongqing Medical University, Chongqing, China.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Changlong
authors.affiliation: Department of Neurosurgery, Yongchuan Hospital, Chongqing Medical University, Chongqing, China. Electronic address: 85938727@qq.com.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Guangwei
authors.affiliation: Department of Neurosurgery, Yongchuan Hospital, Chongqing Medical University, Chongqing, China.
authors.forename: He
authors.initials: H
authors.lastname: Xuenong
authors.affiliation: Department of Neurosurgery, Yongchuan Hospital, Chongqing Medical University, Chongqing, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Xiaohui
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Sun
authors.initials: S
authors.lastname: Xiaochuan
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Xie
authors.initials: X
authors.lastname: Yanfeng
mesh_terms: D000818:Animals; D000873:Anthracenes / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001929:Brain Edema / Q000209:etiology; D001930:Brain Injuries / Q000209:etiology* / Q000401:mortality / Q000517:prevention & control; D053148:Caspase 3 / Q000235:genetics / Q000378:metabolism; D004195:Disease Models, Animal; D004311:Double-Blind Method; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology*; D006624:Hippocampus / Q000378:metabolism*; D000068877:Imatinib Mesylate / Q000627:therapeutic use; D020287:In Situ Nick-End Labeling; D008297:Male; D010982:Platelet-Derived Growth Factor / Q000627:therapeutic use; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D017479:Receptors, Platelet-Derived Growth Factor / Q000378:metabolism*; D013345:Subarachnoid Hemorrhage / Q000150:complications* / Q000188:drug therapy
chemical_list: D000873:Anthracenes; D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D010982:Platelet-Derived Growth Factor; D012333:RNA, Messenger; C432165:pyrazolanthrone; D000068877:Imatinib Mesylate; D017479:Receptors, Platelet-Derived Growth Factor; D053148:Caspase 3
keywords: PDGFR; SAH; apoptosis; early brain injury; encephaledema