title: The Effects of Occupational Exposure of Carbon Disulfide on Sexual Hormones and Semen Quality of Male Workers From a Chemical Fiber Factory.
abstract: This study is aimed to analyze the relationship between occupational CS2 exposure and reproductive impairments.
  
  
  
  Seventy-six CS2-exposed (9.73 ± 2.76 mg/m(3)) male workers and 94 unexposed workers were selected for study. Worker demographics were assessed with a customized questionnaire. Sexual hormones and sperm-related parameters were measured by biochemical or morphological analysis.
  
  
  
  The CS2-exposed workers had significantly higher serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), and lower levels of testosterone (T). Significant decrements were also identified in sperm viability and motility, chromatin, antioxidant capacity, mitochondrial membrane potential, mitochondrial membrane permeability transition pore (MPTP), and respiratory chain Complexes II and IV.
  
  
  
  Our data indicated that occupational CS2 exposure can exert deleterious effects on male sexual hormones and sperm quality, and mitochondrial dysfunction may play a vital role in this process.
authors.affiliation: Shenzhen Center for Disease Control and Prevention (Dr Cheng), Key Laboratory of Molecular Biology, Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong (Drs Guo, Ma), and Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China (Dr Guo, Dr Ma, Chen).
authors.forename: Yinsheng
authors.initials: Y
authors.lastname: Guo
authors.forename: Yue
authors.initials: Y
authors.lastname: Ma
authors.forename: Guoyuan
authors.initials: G
authors.lastname: Chen
authors.forename: Jinquan
authors.initials: J
authors.lastname: Cheng
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000009:adverse effects*; D002246:Carbon Disulfide / Q000009:adverse effects*; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D008928:Mitochondria / Q000473:pathology; D016273:Occupational Exposure / Q000009:adverse effects*; D055101:Semen Analysis; D013076:Sperm Count; D013739:Testosterone / Q000097:blood*
chemical_list: D000395:Air Pollutants, Occupational; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D002246:Carbon Disulfide