title: Potential applications of catestatin in cardiovascular diseases.
abstract: Catestatin (CST) was first named in 1997 for its catecholamine-inhibitory activity. It was discovered as a potent inhibitor of catecholamine secretion and as a regulator of histamine release. Accumulating evidence shows that CST is involved with cardiovascular diseases; however, whether CST is a protective factor for these conditions and the mechanisms by which such actions may be mediated are not well understood. In this article, we review recent basic research and clinical trials in the study of CST and summarize the association of CST with cardiovascular diseases. We review data obtained from MedLine via PubMed and from our own investigations.
authors.affiliation: The Departments of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
authors.forename: Yilin
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Cardiology, Peking University Third Hospital, Key Laboratory of Cardiovascular Molecular Biology & Regulatory Peptides, Ministry of Health & Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing 100191, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Zhu
mesh_terms: D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000209:etiology; D053379:Chromogranin A / Q000097:blood*; D006632:Histamine / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000175:diagnosis; D009203:Myocardial Infarction / Q000175:diagnosis; D010446:Peptide Fragments / Q000097:blood*; D012307:Risk Factors; D015398:Signal Transduction
chemical_list: D015415:Biomarkers; D053379:Chromogranin A; D010446:Peptide Fragments; C109084:chromogranin A (344-364); D006632:Histamine
keywords: AMI; catecholamine; heart failure; histamine; hypertension