title: Association of serum lipid indices and statin consumption with periodontal status.
abstract: OBJECTIVE
  Periodontal and cardiovascular diseases share some common underlying mechanisms. Hyperlipidemia is a major risk factor for cardiovascular diseases. This study sought to assess the association of hyperlipidemia and statin consumption with periodontal status.
  
  
  METHODS
  This cross-sectional study was conducted on 150 participants including 50 individuals with normal lipid profile (group C), 50 hyperlipidemic patients without drug therapy (group N), and 50 hyperlipidemic patients on drug therapy for a minimum of 3 months (group S). Periodontal parameters including plaque index (PI), clinical attachment level (CAL), bleeding on probing (BOP), and pocket depth (PD) were measured for all teeth except for the third molars. Serum levels of total cholesterol (TC), HDL, LDL, and triglycerides (TGs) were measured.
  
  
  RESULTS
  The mean values of CAL and PD were significantly higher in the two hyperlipidemic groups compared with the C group (P < 0.005). Also, CAL and PD had significant associations with serum levels of TGs, LDL, and TC (P < 0.0001); PI in the group S was significantly lower than that in the other groups (P < 0.005).
  
  
  CONCLUSIONS
  Hyperlipidemic patients showed higher values of periodontal parameters compared with the statin-treated and control groups. Lower PI in the group S may indicate the anti-inflammatory effect of statin.
authors.affiliation: Department of Periodontics, Tehran Dental Branch, Islamic Azad University, Tehran, Iran. sayar_f@yahoo.com.
authors.forename: F
authors.initials: F
authors.lastname: Sayar
authors.affiliation: Gastroenterology Department, Milad Hospital, Tehran, Iran.
authors.forename: S
authors.initials: S
authors.lastname: Fallah
authors.affiliation: Department of Mathematics, South Tehran Branch, Islamic Azad University, Tehran, Iran.
authors.forename: N
authors.initials: N
authors.lastname: Akhondi
authors.affiliation: Private Practice, Tehran, Iran.
authors.forename: S
authors.initials: S
authors.lastname: Jamshidi
mesh_terms: D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003430:Cross-Sectional Studies; D003774:Dental Plaque Index; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D006949:Hyperlipidemias / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010510:Periodontal Diseases / Q000150:complications*; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000150:complications; D014280:Triglycerides / Q000097:blood
chemical_list: D000924:Anticholesteremic Agents; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol
keywords: cholesterol; hyperlipidemia; periodontitis; simvastatin