title: Hepatocyte and Sertoli Cell Aquaporins, Recent Advances and Research Trends.
abstract: Aquaporins (AQPs) are proteinaceous channels widespread in nature where they allow facilitated permeation of water and uncharged through cellular membranes. AQPs play a number of important roles in both health and disease. This review focuses on the most recent advances and research trends regarding the expression and modulation, as well as physiological and pathophysiological functions of AQPs in hepatocytes and Sertoli cells (SCs). Besides their involvement in bile formation, hepatocyte AQPs are involved in maintaining energy balance acting in hepatic gluconeogenesis and lipid metabolism, and in critical processes such as ammonia detoxification and mitochondrial output of hydrogen peroxide. Roles are played in clinical disorders including fatty liver disease, diabetes, obesity, cholestasis, hepatic cirrhosis and hepatocarcinoma. In the seminiferous tubules, particularly in SCs, AQPs are also widely expressed and seem to be implicated in the various stages of spermatogenesis. Like in hepatocytes, AQPs may be involved in maintaining energy homeostasis in these cells and have a major role in the metabolic cooperation established in the testicular tissue. Altogether, this information represents the mainstay of current and future investigation in an expanding field.
authors.affiliation: Department of Microscopy, Laboratory of Cell Biology, Institute of Biomedical Sciences Abel Salazar (ICBAS) and Unit for Multidisciplinary Research in Biomedicine (UMIB), University of Porto, 4050-313 Porto, Portugal. raquellbernardino@gmail.com.
authors.forename: Raquel L
authors.initials: RL
authors.lastname: Bernardino
authors.affiliation: Instituto de Fisiolog&#237;a Experimental-CONICET, Facultad de Ciencias Bioqu&#237;micas y Farmac&#233;uticas-Universidad Nacional de Rosario, 531 S2002LRK Rosario, Santa Fe, Argentina. rmarinel@unr.edu.ar.
authors.forename: Raul A
authors.initials: RA
authors.lastname: Marinelli
authors.affiliation: Department of Biosciences, Biotechnologies and Biopharnaceutics, University of Bari "<i>Aldo Moro</i>", 70125 Bari, Italy. anna.maggio1988@gmail.com.
authors.forename: Anna
authors.initials: A
authors.lastname: Maggio
authors.affiliation: Department of Biosciences, Biotechnologies and Biopharnaceutics, University of Bari "<i>Aldo Moro</i>", 70125 Bari, Italy. annapatrizia.gena@uniba.it.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Gena
authors.affiliation: Department of Biosciences, Biotechnologies and Biopharnaceutics, University of Bari "<i>Aldo Moro</i>", 70125 Bari, Italy. ilaria.cataldo@uniba.it.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Cataldo
authors.affiliation: CICS-UBI, Health Sciences Research Centre, University of Beira Interior, 6201-506 Covilh&#227;, Portugal. alvesmarc@gmail.com.
authors.forename: Marco G
authors.initials: MG
authors.lastname: Alves
authors.affiliation: Department of Biosciences, Biotechnologies and Biopharnaceutics, University of Bari "<i>Aldo Moro</i>", 70125 Bari, Italy. maria.svelto@uniba.it.
authors.forename: Maria
authors.initials: M
authors.lastname: Svelto
authors.affiliation: Department of Microscopy, Laboratory of Cell Biology, Institute of Biomedical Sciences Abel Salazar (ICBAS) and Unit for Multidisciplinary Research in Biomedicine (UMIB), University of Porto, 4050-313 Porto, Portugal. pfobox@gmail.com.|Instituto de Investiga&#231;&#227;o e Inova&#231;&#227;o em Sa&#250;de, Universidade do Porto, 4200-135 Porto, Portugal. pfobox@gmail.com.
authors.forename: Pedro F
authors.initials: PF
authors.lastname: Oliveira
authors.affiliation: Department of Biosciences, Biotechnologies and Biopharnaceutics, University of Bari "<i>Aldo Moro</i>", 70125 Bari, Italy. giuseppe.calamita@uniba.it.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Calamita
mesh_terms: D020346:Aquaporins / Q000378:metabolism*; D004734:Energy Metabolism; D022781:Hepatocytes / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D007248:Infertility, Male / Q000378:metabolism / Q000473:pathology; D008297:Male; D008928:Mitochondria / Q000378:metabolism; D065626:Non-alcoholic Fatty Liver Disease / Q000378:metabolism / Q000473:pathology; D017382:Reactive Oxygen Species / Q000378:metabolism; D012708:Sertoli Cells / Q000166:cytology / Q000378:metabolism*
chemical_list: D020346:Aquaporins; D017382:Reactive Oxygen Species
keywords: Non-Alcoholic Fatty Liver Disease (NAFLD); bile formation; liver; male fertility; metabolic homeostasis; mitochondria; reactive oxygen species (ROS); spermatogenesis; testis