title: Long non-coding RNA TUG1 promotes colorectal cancer metastasis via EMT pathway.
abstract: Colorectal cancer (CRC) is the third most common malignancy in developed countries, and its incidence rate has been continuously increasing in developing countries over the past few decades. Taurine-upregulated gene 1 (TUG1) plays an important role in signal transduction, regulation of cell morphology, migration, proliferation and apoptosis. The aim of the present study was to evaluate the role of TUG1 in CRC, and whether knockdown of TUG1 expression could affect cell proliferation, migration and invasion of CRC cell lines. Here, we reported that TUG1 was upregulated in CRC. Further experiments revealed that TUG1 knockdown significantly inhibited cell proliferation, migration and invasion of CRC in vitro. Above all, knockdown of TUG1 may represent a rational therapeutic strategy for CRC patients in future.
authors.affiliation: Department of Gastrointestinal Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Biliary Pancreatic Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
authors.forename: Zhenxian
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: Department of Gastrointestinal Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
authors.forename: Weidong
authors.initials: W
authors.lastname: Feng
authors.affiliation: Department of Gastrointestinal Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Ye
authors.affiliation: Department of Gastrointestinal Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
authors.forename: Weigang
authors.initials: W
authors.lastname: Dai
authors.affiliation: Department of Gastrointestinal Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
authors.forename: Changhua
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Gastrointestinal Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Peng
authors.affiliation: Department of Gastrointestinal Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
authors.forename: Kaiming
authors.initials: K
authors.lastname: Wu
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology*; D017209:Apoptosis / Q000235:genetics; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000235:genetics; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology*; D058750:Epithelial-Mesenchymal Transition / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D055785:Gene Knockdown Techniques; D045325:HCT116 Cells; D057809:HEK293 Cells; D006801:Humans; D009362:Neoplasm Metastasis; D062085:RNA, Long Noncoding / Q000502:physiology*; D015398:Signal Transduction / Q000235:genetics
chemical_list: D062085:RNA, Long Noncoding; C000598536:TUG1 long noncoding RNA, human
keywords: CRC; EMT; TUG1; long noncoding RNA