title: Chronic Anal Fissure: A Comparative Study of Medical Treatment Versus Surgical Sphincterotomy.
abstract: To determine whether the medical Treatment of anal fissure can be an effective alternative for surgery Methods: Retrospectively, we randomly selected 190 Patients being treated for anal fissure between the years 2005-2010 in 3 equal groups: group A: Patients who received medical treatment with topical nitroglycerin, group B: Patient treated with topical diltiazem, and group C: Patients underwent surgery. The results were then correlated with the statistical program SPSS using chi-square test. Main complaints of the patients were first anal pain and then bleeding. The response to treatments for relieving pain was: 77% in A, 83% in B, and 98% in group C. Response of treatments for fissure healing, in order of groups A, B and C was: 74%, 83%, and 94%. Despite good response to medical treatment, surgical treatment was more effective and medical treatment of choice in patients who are willing to have surgery.
authors.affiliation: Department of General Surgery, Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Motie
authors.affiliation: Department of General Surgery, Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Parham
authors.initials: P
authors.lastname: Hashemi
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D001003:Anal Canal / Q000601:surgery; D002908:Chronic Disease; D013505:Digestive System Surgical Procedures / Q000379:methods*; D004110:Diltiazem / Q000008:administration & dosage*; D005260:Female; D005401:Fissure in Ano / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000008:administration & dosage*; D059408:Pain Management / Q000379:methods; D012189:Retrospective Studies; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D014665:Vasodilator Agents; D004110:Diltiazem; D005996:Nitroglycerin
keywords: Anal fissure; Diltiazem ointment; Lateral internal sphincterotomy; Nitroglycerin