title: Effects of late exercise on cardiac remodeling and myocardial calcium handling proteins in rats with moderate and large size myocardial infarction.
abstract: BACKGROUND
  Physical exercise attenuates myocardial infarction (MI)-induced cardiac remodeling. However, it is unsettled whether late exercise modulates post-infarction cardiac remodeling differentially according to infarct size. We investigated the effects of exercise started at late stage heart failure on cardiac remodeling in rats with moderate and large sized MI.
  
  
  METHODS
  Three months after MI, rats were assigned into sedentary and exercise groups. Exercise rats underwent treadmill for three months. After assessing infarct size by histological analysis, rats were subdivided into four groups: moderate MI sedentary (Mod MI-Sed; n=7), Mod MI exercised (Mod MI-Ex; n=7), Large MI-Sed (n=11), and Large MI-Ex (n=10).
  
  
  RESULTS
  Before exercise, MI-induced cardiac changes were demonstrated by comparing results to a Sham group; alterations were more intense in rats with large than moderate MI size. Systolic function, evaluated by echocardiogram using the variation in LV fractional area change between after and before exercise, was improved in exercise than sedentary groups. Calsequestrin expression increased in exercised compared to sedentary groups. L-type calcium channel was higher in Mod MI-Ex than Mod MI-Sed. SERCA2a, phospholamban, and Na(+)/Ca(2+) exchanger expression did not differ between groups.
  
  
  CONCLUSIONS
  Late exercise improves systolic function and modulates intracellular calcium signaling proteins in rats with moderate and large MI.
authors.affiliation: Internal Medicine Department, Botucatu Medical School, Sao Paulo State University, UNESP, Botucatu, Brazil.
authors.forename: Daniele M
authors.initials: DM
authors.lastname: Guizoni
authors.affiliation: School of Physical Therapy, Federal University of Mato Grosso do Sul, Campo Grande, Brazil.
authors.forename: Silvio A
authors.initials: SA
authors.lastname: Oliveira-Junior
authors.affiliation: Internal Medicine Department, Botucatu Medical School, Sao Paulo State University, UNESP, Botucatu, Brazil.
authors.forename: Sefora L R
authors.initials: SL
authors.lastname: Noor
authors.affiliation: Internal Medicine Department, Botucatu Medical School, Sao Paulo State University, UNESP, Botucatu, Brazil.
authors.forename: Luana U
authors.initials: LU
authors.lastname: Pagan
authors.affiliation: Internal Medicine Department, Botucatu Medical School, Sao Paulo State University, UNESP, Botucatu, Brazil; School of Physical Therapy, Federal University of Mato Grosso do Sul, Campo Grande, Brazil.
authors.forename: Paula F
authors.initials: PF
authors.lastname: Martinez
authors.affiliation: Internal Medicine Department, Botucatu Medical School, Sao Paulo State University, UNESP, Botucatu, Brazil.
authors.forename: Aline R R
authors.initials: AR
authors.lastname: Lima
authors.affiliation: Internal Medicine Department, Botucatu Medical School, Sao Paulo State University, UNESP, Botucatu, Brazil.
authors.forename: Mariana J
authors.initials: MJ
authors.lastname: Gomes
authors.affiliation: Internal Medicine Department, Botucatu Medical School, Sao Paulo State University, UNESP, Botucatu, Brazil.
authors.forename: Ricardo L
authors.initials: RL
authors.lastname: Damatto
authors.affiliation: Internal Medicine Department, Botucatu Medical School, Sao Paulo State University, UNESP, Botucatu, Brazil.
authors.forename: Marcelo D M
authors.initials: MD
authors.lastname: Cezar
authors.affiliation: Internal Medicine Department, Botucatu Medical School, Sao Paulo State University, UNESP, Botucatu, Brazil.
authors.forename: Camila
authors.initials: C
authors.lastname: Bonomo
authors.affiliation: Internal Medicine Department, Botucatu Medical School, Sao Paulo State University, UNESP, Botucatu, Brazil.
authors.forename: Leonardo A M
authors.initials: LA
authors.lastname: Zornoff
authors.affiliation: Internal Medicine Department, Botucatu Medical School, Sao Paulo State University, UNESP, Botucatu, Brazil.
authors.forename: Katashi
authors.initials: K
authors.lastname: Okoshi
authors.affiliation: Internal Medicine Department, Botucatu Medical School, Sao Paulo State University, UNESP, Botucatu, Brazil. Electronic address: mpoliti@fmb.unesp.br.
authors.forename: Marina P
authors.initials: MP
authors.lastname: Okoshi
mesh_terms: D000818:Animals; D020746:Calcium Channels, L-Type / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D004195:Disease Models, Animal; D006333:Heart Failure / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D009043:Motor Activity / Q000502:physiology; D009203:Myocardial Infarction / Q000150:complications*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D005082:Physical Exertion / Q000502:physiology; D051381:Rats; D020257:Ventricular Remodeling / Q000502:physiology*
chemical_list: D020746:Calcium Channels, L-Type; D002135:Calcium-Binding Proteins
keywords: Calsequestrin; Cardiac function; Echocardiogram; Myocardial infarction; Physical exercise; Remodeling