title: Ankylosing Spondylitis Patients with HLA-B*2704 have More Uveitis than Patients with HLA-B*2705 in a North Chinese Population.
abstract: OBJECTIVE
  To investigate the correlation between clinical features of ankylosing spondylitis (AS) and different human leukocyte antigen (HLA)-B27 subtypes.
  
  
  METHODS
  We conducted a cross-sectional study of 216 patients with AS. HLA-B27 and its subtypes were detected by polymerase chain reaction with sequence specific primer (PCR-SSP). Clinical features were compared between the different HLA-B27 subtypes. A meta-analysis on uveitis frequencies in AS patients with HLA-B*2705 vs 2704 was performed.
  
  
  RESULTS
  The most prevalent subtypes of HLA-B27 were HLA-B*2704 (66.1%) and HLA-B*2705 (32.2%). There were 57 HLA-B27-positive AS patients with the history of uveitis; 45 were B*2704 and 12 were B*2705. Patients with B*2704 had more uveitis than B*2705 (p = 0.021). After meta-analysis, there was no significant difference in the presence of uveitis between HLA-B*2704 and HLA-B*2705.
  
  
  CONCLUSIONS
  AS patients with B*2704 have a higher risk of uveitis than AS with B*2705 in a north Chinese people.
authors.affiliation: a Third Affiliated Hospital of Sun Yat-sen University, General Hospital of Ningxia Medical University , Department of Rheumatology , Yinchuan , China.
authors.forename: Haibo
authors.initials: H
authors.lastname: Li
authors.affiliation: b Third Affiliated Hospital of Sun Yat-sen University , Department of Rheumatology , Guangzhou , China.
authors.forename: Qiuxia
authors.initials: Q
authors.lastname: Li
authors.affiliation: c General Hospital of Ningxia Medical University , Department of Rheumatology , Yinchuan , China.
authors.forename: Chen
authors.initials: C
authors.lastname: Ji
authors.affiliation: b Third Affiliated Hospital of Sun Yat-sen University , Department of Rheumatology , Guangzhou , China.
authors.forename: Jieruo
authors.initials: J
authors.lastname: Gu
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D002681:China; D003430:Cross-Sectional Studies; D017931:DNA Primers / Q000737:chemistry; D005260:Female; D015796:HLA-B27 Antigen / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D013167:Spondylitis, Ankylosing / Q000175:diagnosis / Q000235:genetics*; D014605:Uveitis / Q000175:diagnosis / Q000235:genetics*; D055815:Young Adult
chemical_list: D017931:DNA Primers; C510610:HLA-B*27:04 antigen; C464936:HLA-B*27:05 antigen; D015796:HLA-B27 Antigen
keywords: Ankylosing spondylitis; Chinese; HLA-B*2704; HLA-B*2705; uveitis