title: [Clinical course and differential diagnosis of thrombotic microangiopathy].
abstract: Thrombotic microangiopathies are complex diseases, requiring early differential diagnosis and targeted intervention.
  
  
  
  Presentation of clinical phenotype and diagnostic algorithm, discussion of underlying pathophysiology, clinical management and therapy.
  
  
  
  Summary of current knowledge from literature and expert opinion.
  
  
  
  Our understanding of pathophysiology and therapeutic options have changed substantially in recent years. Early differential diagnosis and targeted therapy are of prognostic relevance.
  
  
  
  A better understanding of underlying pathophysiology, increased clinical awareness and novel therapeutic options allow for a better prognosis of patients with thrombotic microangiopathy.
authors.affiliation: Medizinische Klinik IV, Abteilung für Endokrinologie und Diabetologie, Angiologie, Nephrologie und Klinische Chemie, Universitätsklinikum Tübingen, Otfried-Müller-Str. 10, 72076, Tübingen, Deutschland. martina.guthoff@med.uni-tuebingen.de.
authors.forename: M
authors.initials: M
authors.lastname: Guthoff
authors.affiliation: Medizinische Klinik IV, Abteilung für Endokrinologie und Diabetologie, Angiologie, Nephrologie und Klinische Chemie, Universitätsklinikum Tübingen, Otfried-Müller-Str. 10, 72076, Tübingen, Deutschland.
authors.forename: N
authors.initials: N
authors.lastname: Heyne
mesh_terms: D003937:Diagnosis, Differential; D006801:Humans; D010951:Plasma Exchange; D011379:Prognosis; D011697:Purpura, Thrombotic Thrombocytopenic / Q000175:diagnosis; D057049:Thrombotic Microangiopathies / Q000175:diagnosis
keywords: STEC-HUS; TTP; Thrombotic microangiopathy; aHUS