title: Diagnostic criteria that can most accurately differentiate allergic bronchopulmonary mycosis from other eosinophilic lung diseases: A retrospective, single-center study.
abstract: BACKGROUND
  Several diagnostic criteria have been proposed to differentiate allergic bronchopulmonary mycosis (ABPM) from asthma, but there have been no studies to establish diagnostic criteria to classify ABPM differently from other eosinophilic lung diseases.
  
  
  METHODS
  We retrospectively investigated both patients with ABPM (n=42) diagnosed by clinical (Rosenberg-Patterson criteria modified to apply to fungi other than Aspergillus spp., with consideration of computed tomography and bronchoscopy findings) or pathological criteria and those with other eosinophilic lung diseases (n=118) to establish elaborate diagnostic criteria for ABPM.
  
  
  RESULTS
  Etiologies of ABPM included fungi other than Aspergillus spp. or unidentified pathogens in 16 patients. Fourteen patients (33.3%) did not have asthma. When the diagnostic cutoff line was set to satisfy six or more primary plus secondary modified Rosenberg-Patterson criteria, ABPM could be diagnosed with good sensitivity, specificity, and positive/negative predictive values (97.6%, 98.3%, 95.3%, and 99.1%, respectively). When the diagnostic criteria were combined with pathological criteria, the values further improved to 100%, 98.3%, 95.5%, and 100%, respectively.
  
  
  CONCLUSIONS
  Our results suggest that these novel criteria offer good sensitivity, specificity, and positive/negative predictive values for the diagnosis and classification of ABPM.
authors.affiliation: Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, 1696 Itai, Kumagaya City, Saitama Pref. 360-0105, Japan. Electronic address: ishiguro.takashi@pref.saitama.lg.jp.
authors.forename: Takashi
authors.initials: T
authors.lastname: Ishiguro
authors.affiliation: Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, 1696 Itai, Kumagaya City, Saitama Pref. 360-0105, Japan. Electronic address: takayanagi.noboru@pref.saitama.lg.jp.
authors.forename: Noboru
authors.initials: N
authors.lastname: Takayanagi
authors.affiliation: Department of Biomedical Statistics and Bioinformatics, Kyoto University Graduate School of Medicine, Kyoto, Japan. Electronic address: uozumi@kuhp.kyoto-u.ac.jp.
authors.forename: Ryuji
authors.initials: R
authors.lastname: Uozumi
authors.affiliation: Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, 1696 Itai, Kumagaya City, Saitama Pref. 360-0105, Japan. Electronic address: koyuringo42@gmail.com.
authors.forename: Yuri
authors.initials: Y
authors.lastname: Baba
authors.affiliation: Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, 1696 Itai, Kumagaya City, Saitama Pref. 360-0105, Japan. Electronic address: kawate.eriko.am@pref.saitama.lg.jp.
authors.forename: Eriko
authors.initials: E
authors.lastname: Kawate
authors.affiliation: Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, 1696 Itai, Kumagaya City, Saitama Pref. 360-0105, Japan. Electronic address: m00039yk@jichi.ac.jp.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Kobayashi
authors.affiliation: Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, 1696 Itai, Kumagaya City, Saitama Pref. 360-0105, Japan. Electronic address: takaku.yotaro@pref.saitama.lg.jp.
authors.forename: Yotaro
authors.initials: Y
authors.lastname: Takaku
authors.affiliation: Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, 1696 Itai, Kumagaya City, Saitama Pref. 360-0105, Japan. Electronic address: kagiyama.naho@pref.saitama.lg.jp.
authors.forename: Naho
authors.initials: N
authors.lastname: Kagiyama
authors.affiliation: Department of Pathology, Saitama Cardiovascular and Respiratory Center, Saitama, Japan. Electronic address: shimizu.yoshihiko@pref.saitama.lg.jp.
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Shimizu
authors.affiliation: Department of Biomedical Statistics and Bioinformatics, Kyoto University Graduate School of Medicine, Kyoto, Japan. Electronic address: smorita@kuhp.kyoto-u.ac.jp.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Morita
authors.affiliation: Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, 1696 Itai, Kumagaya City, Saitama Pref. 360-0105, Japan. Electronic address: sugita.yutaka.am@pref.saitama.lg.jp.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Sugita
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D055744:Invasive Pulmonary Aspergillosis / Q000175:diagnosis*; D008171:Lung Diseases / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D011657:Pulmonary Eosinophilia / Q000175:diagnosis*; D012189:Retrospective Studies
keywords: Allergic bronchopulmonary mycosis; Aspergillosis; Classification criteria; Diagnosis; Eosinophilic lung diseases