title: Antimicrobial effect of platelet-rich plasma and platelet-rich fibrin.
abstract: BACKGROUND
  Platelet concentrates have been extensively used in a variety of medical fields to promote soft- and hard-tissue regeneration. The significance behind their use lies in the abundance of growth factors (GFs) in platelets α-granules that promote wound healing. Other than releasing a pool of GFs upon activation, platelets also have many features that indicate their role in the anti-infective host defense.
  
  
  OBJECTIVE
  The aim of this study is to evaluate the antimicrobial activities of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) against periodontal disease-associated bacteria.
  
  
  METHODS
  Blood samples were obtained from ten adult male patients. PRP and PRF were procured using centrifugation. The antimicrobial activity of PRP and PRF was evaluated by microbial culturing using bacterial strains of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans.
  
  
  RESULTS
  P. gingivalis and A. actinomycetemcomitans were inhibited by PRP but not by PRF.
  
  
  CONCLUSIONS
  PRP is a potentially useful substance in the fight against periodontal pathogens. This might represent a valuable property in adjunct to the enhancement of tissue regeneration.
authors.affiliation: Department of Periodontology, MGV's KBH Dental College and Hospital, Nashik, Maharashtra, India.
authors.forename: Pallavi S
authors.initials: PS
authors.lastname: Badade
authors.affiliation: Department of Periodontology, MGV's KBH Dental College and Hospital, Nashik, Maharashtra, India.
authors.forename: Swapna A
authors.initials: SA
authors.lastname: Mahale
authors.affiliation: Department of Periodontology, MGV's KBH Dental College and Hospital, Nashik, Maharashtra, India.
authors.forename: Alisha A
authors.initials: AA
authors.lastname: Panjwani
authors.affiliation: Department of Periodontology, MGV's KBH Dental College and Hospital, Nashik, Maharashtra, India.
authors.forename: Prutha D
authors.initials: PD
authors.lastname: Vaidya
authors.affiliation: Department of Periodontology, MGV's KBH Dental College and Hospital, Nashik, Maharashtra, India.
authors.forename: Ayushya D
authors.initials: AD
authors.lastname: Warang
mesh_terms: D000328:Adult; D016976:Aggregatibacter actinomycetemcomitans / Q000187:drug effects*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001792:Blood Platelets / Q000502:physiology*; D005337:Fibrin / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D053657:Platelet-Rich Plasma / Q000502:physiology*; D016966:Porphyromonas gingivalis / Q000187:drug effects*
chemical_list: D000890:Anti-Infective Agents; D005337:Fibrin