title: Serum Ferritin as Risk Factor for Veno-occlusive Disease of the Liver. Prospective Cohort Study.
abstract: Veno-occlusive disease of the liver (VOD) is an important complication in hematological transplantation. The aim of this study is to analyze the risk factors for VOD and other forms of liver toxicity in a cohort of 180 peripheral stem cell transplants performed in our Center. We find that elevated pretransplant levels of serum ferritin are the most important risk marker for VOD. We believe that ferritin reflects damage induced by oxygen radicals resulting from iron-mediated catalysis. We also discuss different risk factors for VOD and other forms of liver toxicity, suggesting diferent pathogenic mechanisms.
authors.affiliation: a Servicio de Hematología y Hemoterapia , Madrid . Spain.
authors.forename: M
authors.initials: M
authors.lastname: Morado
authors.affiliation: a Servicio de Hematología y Hemoterapia , Madrid . Spain.
authors.forename: E
authors.initials: E
authors.lastname: Ojeda
authors.affiliation: a Servicio de Hematología y Hemoterapia , Madrid . Spain.
authors.forename: J
authors.initials: J
authors.lastname: Garcia-Bustos
authors.affiliation: a Servicio de Hematología y Hemoterapia , Madrid . Spain.
authors.forename: M J
authors.initials: MJ
authors.lastname: Aguado
authors.affiliation: a Servicio de Hematología y Hemoterapia , Madrid . Spain.
authors.forename: R
authors.initials: R
authors.lastname: Arrieta
authors.affiliation: a Servicio de Hematología y Hemoterapia , Madrid . Spain.
authors.forename: E
authors.initials: E
authors.lastname: Quevedo
authors.affiliation: b Statistics, Hospital " La Paz ", Madrid . Spain.
authors.forename: A
authors.initials: A
authors.lastname: Navas
authors.affiliation: a Servicio de Hematología y Hemoterapia , Madrid . Spain.
authors.forename: F
authors.initials: F
authors.lastname: Hernandez-Navarro
keywords: Veno-occlusive disease; liver toxicity; peripheral stem cell transplantation; risk factors; serum ferritin