title: Low serum 25-hydroxyvitamin D level and risk of urinary tract infection in infants.
abstract: The aim of the study is to determine whether serum 25-hydroxyvitamin D (25(OH)D) deficiency in infants increased odds of urinary tract infection (UTI). A total of 238 infants including 132 patients experiencing a first episode of UTI and 106 controls, aged from 1 to 12 months, were enrolled. Serum 25(OH)D levels were tested through blood sampling. The serum 25(OH)D levels were significantly lower in cases with UTI than controls. The mean serum 25(OH)D levels were 29.09 ± 9.56 ng/mL in UTIs and 38.59 ± 12.41 ng/mL in controls (P < 0.001). Infants with acute pyelonephritis (APN) had lower serum 25(OH)D than those with lower UTI. The multivariate logistic regression analyses showed that serum 25(OH)D < 20 ng/mL (OR 5.619, 95% CI 1.469-21.484, P = 0.012) was positively related to an increased odds of UTI. Vitamin D supplementation (OR 0.298, 95% CI 0.150-0.591; P = 0.001) was associated with a decreased likelihood of UTI. Vitamin D deficiency in infants was associated with an increased odds of UTI. Interventional studies evaluating the role of vitamin D supplementation to reduce the burden of UTI are warranted.
authors.affiliation: Department of Pediatric, Zhujiang Hospital of Southern Medical University, Guangzhou Department of Pediatric, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Department of Pediatric, Central Hospital of Panyu District, Guangzhou Department of Clinical Laboratory, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors.forename: Jianhuan
authors.initials: J
authors.lastname: Yang
authors.forename: Guangdao
authors.initials: G
authors.lastname: Chen
authors.forename: Dexuan
authors.initials: D
authors.lastname: Wang
authors.forename: Minguang
authors.initials: M
authors.lastname: Chen
authors.forename: Chao
authors.initials: C
authors.lastname: Xing
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
mesh_terms: D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012307:Risk Factors; D014552:Urinary Tract Infections / Q000097:blood* / Q000453:epidemiology* / Q000209:etiology; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000150:complications
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D