title: Collapsing Glomerulopathy in a Child with Galloway-Mowat Syndrome.
abstract: Galloway-Mowat syndrome (GMS) is an autosomal recessive disorder with a poor prognosis that was first defined as a triad of central nervous system involvement, hiatal hernia, and nephrotic syndrome. However, this syndrome is now known to have a heterogeneous clinical presentation. The nephrotic syndrome is steroid resistant and is responsible for the outcome. The combination of collapsing glomerulopathy and GMS is very rare. A 26-month-old boy presented with steroid-resistant nephrotic syndrome associated with neurologic findings, including microcephaly, psychomotor retardation, and nystagmus. Magnetic resonance imaging showed marked cerebral atrophy, optic atrophy, and hypomyelination. A renal biopsy was consistent with collapsing glomerulopathy. If collapsing glomerulopathy is associated with neurological abnormalities, especially with microcephaly, clinicians should consider GMS as a possible underlying cause.
authors.affiliation: Department of Pediatric Nephrology, Gulhane Military Medical Academy, Etlik, Kecioren, 06100 Ankara, Turkey.
authors.forename: Cengiz
authors.initials: C
authors.lastname: Zeybek
authors.affiliation: Department of Pediatrics, Gulhane Military Medical Academy, Etlik, Kecioren, 06100 Ankara, Turkey.
authors.forename: Gokalp
authors.initials: G
authors.lastname: Basbozkurt
authors.affiliation: Department of Radiology, Gulhane Military Medical Academy, Etlik, Kecioren, 06100 Ankara, Turkey.
authors.forename: Salih
authors.initials: S
authors.lastname: Hamcan
authors.affiliation: Department of Pathology, Gulhane Military Medical Academy, Etlik, Kecioren, 06100 Ankara, Turkey.
authors.forename: Ayhan
authors.initials: A
authors.lastname: Ozcan
authors.affiliation: Department of Medical Genetics, Gulhane Military Medical Academy, Etlik, Kecioren, 06100 Ankara, Turkey.
authors.forename: Davut
authors.initials: D
authors.lastname: Gul
authors.affiliation: Department of Pediatric Nephrology, Gulhane Military Medical Academy, Etlik, Kecioren, 06100 Ankara, Turkey.
authors.forename: Faysal
authors.initials: F
authors.lastname: Gok