title: [Advances in the research of biological characters and pathophysiological effects of dendritic epidermal T lymphocytes].
abstract: The maturation of dendritic epidermal T lymphocytes (DETCs) in thymus needs ligand-mediated positive selection, and positive selection together with V3γ(+) γδT lymphocytes intrinsic program features order DETCs to specifically migrate to epidermis. Positive selection promotes DETCs to express CD122, which is vital for DETCs to survive and proliferate in skin. DETCs possess memory-like phenotype and are able to rapidly respond to danger signals when they move out from thymus. NKG2D, junctional adhesion molecule-like protein and 2B4 are demonstrated to participate in DETCs activation, except for ligands of T lymphocytes receptor. Effective DETCs secrete cytokines such as interferon-γ, insulin-like growth factor-2, keratinocyte growth factor and gain cytotoxicity to directly kill tumor cells. DETCs participate in skin immune surveillance, regulation of local inflammation, and wound healing promotion.
authors.affiliation: Institute of Burn Research, Southwest Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, the Third Military Medical University, Chongqing 400038, China.
authors.forename: Y S
authors.initials: YS
authors.lastname: Li
authors.forename: W F
authors.initials: WF
authors.lastname: He
authors.forename: J
authors.initials: J
authors.lastname: Wu
mesh_terms: D015703:Antigens, CD / Q000378:metabolism; D002465:Cell Movement; D000078404:Epidermal Cells; D004817:Epidermis / Q000276:immunology*; D051523:Fibroblast Growth Factor 7 / Q000378:metabolism; D006801:Humans; D007157:Immunologic Surveillance; D007249:Inflammation / Q000276:immunology; D007335:Insulin-Like Growth Factor II / Q000378:metabolism; D007371:Interferon-gamma / Q000378:metabolism; D053646:Interleukin-2 Receptor beta Subunit / Q000378:metabolism; D062726:Junctional Adhesion Molecules / Q000378:metabolism; D055655:NK Cell Lectin-Like Receptor Subfamily K; D011971:Receptors, Immunologic / Q000378:metabolism; D000071176:Signaling Lymphocytic Activation Molecule Family; D012867:Skin / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology*; D013950:Thymus Gland / Q000166:cytology; D014945:Wound Healing / Q000276:immunology
chemical_list: D015703:Antigens, CD; C084093:CD244 protein, human; C496453:FGF7 protein, human; C573415:IFNG protein, human; C035170:IGF2 protein, human; D053646:Interleukin-2 Receptor beta Subunit; D062726:Junctional Adhesion Molecules; C527085:KLRK1 protein, human; D055655:NK Cell Lectin-Like Receptor Subfamily K; D011971:Receptors, Immunologic; D000071176:Signaling Lymphocytic Activation Molecule Family; D051523:Fibroblast Growth Factor 7; D007335:Insulin-Like Growth Factor II; D007371:Interferon-gamma