title: Promises and pitfalls of relating alteration of white matter pathways causing improvement in cognitive performance.
abstract: Here, we argue systematically about the promises and pitfalls of relating Human Connectome to cognitive enhancement. We also highlight three key areas where further resolution is required before the generalization of the white-matter-related cause of cognitive enhancement across a variety of cognitive modalities is made. These key areas are: (a) inherent limitations in estimating of diffusion-weighted anisotropy index near volumes with high abundance of crossing fibers; (b) species differences in cell types and only a putative link between brain rhythms and modulation of activity in precursor cells in rodents;
authors.affiliation: a Cognitive Science Lab , International Institute of Information Technology , Hyderabad , India.
authors.forename: Dipanjan
authors.initials: D
authors.lastname: Roy
authors.affiliation: b Centre of Behavioural and Cognitive Sciences , University of Allahabad , Allahabad , India.
authors.forename: V S Chandrasekhar
authors.initials: VS
authors.lastname: Pammi
mesh_terms: D001921:Brain; D001931:Brain Mapping; D003071:Cognition; D006801:Humans; D011930:Reaction Time; D066127:White Matter
keywords: Cognitive enhancement; Human Connectome; brain rhythms; diffusion weighted; precursor cells; white matter