title: Identification and Structural Characterization of Acylgluconic Acids, Flavonol Glycosides, Limonoids and Alkaloids from the Fruits of Evodia Rutaecarpa by High Performance Liquid Chromatography Coupled to Electrospray Ionization and Quadrupole Time-of-Flight Mass Spectrometry.
abstract: The dried fruit of Evodia rutaecarpa (Juss.) Benth. (ER) is a well-known traditional Chinese medicine and has been used in treatment of headache, abdominal pain, migraine, chill limbs, diarrhea, nausea, hyperbaropathy, dysmenorrheal and postpartum hemorrhage. In this work, a comprehensive characterization of chemical constituents in ER extract is carried out by high performance liquid chromatography coupled to electrospray ionization and quadrupole time-of-flight mass spectrometry. The increased power of higher mass resolution and exact mass measurements for precursor and fragment ions lead to detection of 3 acylgluconic acids, 3 flavonol glycosides, 6 limonoids and 24 alkaloids in ER, of which 6 quinolone alkaloids has not been reported previously to our best knowledge. This research enriches our knowledge of chemical constituents of ER and provides a reliable guide for further pharmacology and active mechanism study on this herb.
authors.affiliation: Department of Pharmaceutical and Life Sciences, Jiujiang University, Jiujiang 332005, People's Republic of China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Ling
authors.affiliation: Department of Pharmaceutical and Life Sciences, Jiujiang University, Jiujiang 332005, People's Republic of China.|Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.
authors.forename: Pei
authors.initials: P
authors.lastname: Hu
authors.affiliation: Department of Pharmaceutical and Life Sciences, Jiujiang University, Jiujiang 332005, People's Republic of China.
authors.forename: Lifang
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Pharmaceutical and Life Sciences, Jiujiang University, Jiujiang 332005, People's Republic of China.
authors.forename: Hongguang
authors.initials: H
authors.lastname: Jin
authors.affiliation: Department of Pharmaceutical and Life Sciences, Jiujiang University, Jiujiang 332005, People's Republic of China.
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Pharmaceutical and Life Sciences, Jiujiang University, Jiujiang 332005, People's Republic of China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Tao
authors.affiliation: Department of Pharmaceutical and Life Sciences, Jiujiang University, Jiujiang 332005, People's Republic of China.
authors.forename: Ling
authors.initials: L
authors.lastname: Huang
authors.affiliation: Department of Pharmaceutical and Life Sciences, Jiujiang University, Jiujiang 332005, People's Republic of China.
authors.forename: Ruoyu
authors.initials: R
authors.lastname: Ren