title: [Uterine necrosis upon acute caesarean section in a homozygous factor VLeiden patient].
abstract: Peripartum hysterectomy is a rare but life-saving procedure. Haemorrhage, atony, placenta accreta/praevia or uterus rupture are the most common reasons for hysterectomy. This case report presents a 35-year-old woman, gravida 2, para 1, with total necrosis of the uterus and ovaries bilaterally after an acute caesarean section. Pathological examination showed thrombosis and haemorrhagic infarction. Besides pre-eclampsia the patient had no co-morbidity. Later analysis found homozygosity for factor VLeiden mutation. Hysterectomy was life-saving but the patient developed acute renal failure with late recovery.
authors.affiliation: sondergaardp@gmail.com.
authors.forename: Peter Søndergaard
authors.initials: PS
authors.lastname: Thyrrestrup
authors.forename: Charlotte Brix
authors.initials: CB
authors.lastname: Andersson
authors.forename: Søren
authors.initials: S
authors.lastname: Kjærgaard
mesh_terms: D000208:Acute Disease; D000328:Adult; D002585:Cesarean Section; D005165:Factor V / Q000235:genetics*; D005260:Female; D006720:Homozygote; D006801:Humans; D007044:Hysterectomy; D009336:Necrosis / Q000601:surgery*; D010053:Ovary / Q000473:pathology / Q000601:surgery; D017354:Point Mutation; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000209:etiology / Q000601:surgery; D014599:Uterus / Q000473:pathology* / Q000601:surgery
chemical_list: C095381:factor V Leiden; D005165:Factor V