title: Type 2 diabetes: genetic data sharing to advance complex disease research.
abstract: As with other complex diseases, unbiased association studies followed by physiological and experimental characterization have for years formed a paradigm for identifying genes or processes of relevance to type 2 diabetes mellitus (T2D). Recent large-scale common and rare variant genome-wide association studies (GWAS) suggest that substantially larger association studies are needed to identify most T2D loci in the population. To hasten clinical translation of genetic discoveries, new paradigms are also required to aid specialized investigation of nascent hypotheses. We argue for an integrated T2D knowledgebase, designed for a worldwide community to access aggregated large-scale genetic data sets, as one paradigm to catalyse convergence of these efforts.
authors.affiliation: Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, Massachusetts 02142, USA.|Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02062, USA.
authors.forename: Jason
authors.initials: J
authors.lastname: Flannick
authors.affiliation: Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, Massachusetts 02142, USA.|Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02062, USA.|Diabetes Research Center, Diabetes Unit, Department of Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02062, USA.|Department of Medicine, Harvard Medical School, 25 Shattuck Street, Boston, Massachusetts 02115, USA.
authors.forename: Jose C
authors.initials: JC
authors.lastname: Florez
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D033181:Information Dissemination / Q000379:methods*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*