title: Multiple breath washout of hyperpolarized129Xe and3He in human lungs with three-dimensional balanced steady-state free-precession imaging.
abstract: To compare quantitative fractional ventilation measurements from multiple breath washout imaging (MBW-I) using hyperpolarized3He with both spoiled gradient echo (SPGR) and balanced steady-state free precession (bSSFP) three-dimensional (3D) pulse sequences and to evaluate the feasibility of MBW-I with hyperpolarized129Xe.
  
  
  
  Seven healthy subjects were scanned using3He MBW-I with 3D SPGR and bSSFP sequences. Five also underwent MBW-I with129Xe. A dual-tuned coil was used to acquire MBW-I data from both nuclei in the same subject position, enabling direct comparison of regional information.
  
  
  
  High-quality MBW images were obtained with bSSFP sequences using a reduced dose (100 mL) of inhaled hyperpolarized3He. 3D MBW-I with129Xe was also successfully demonstrated with a bSSFP sequence. Regional quantitative ventilation measures derived from3He and129Xe MBW-I correlated well in all subjects (P < 0.001) with mean Pearson's correlation coefficients of r = 0.61 and r = 0.52 for3He SPGR-bSSFP and129Xe-3He (bSSFP) comparisons. The average intersubject mean difference (and standard deviation) in fractional ventilation in SPGR-bSSFP and129Xe-3He comparisons was 15% (28%) and 9% (38%), respectively.
  
  
  
  Improved sensitivity in MBW-I can be achieved with polarization-efficient bSSFP sequences. Same scan-session 3D MBW-I with3He and129Xe has been demonstrated using a dual-tuned coil. Magn Reson Med 77:2288-2295, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
authors.affiliation: POLARIS, Unit of Academic Radiology, Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom.
authors.forename: Felix C
authors.initials: FC
authors.lastname: Horn
authors.affiliation: POLARIS, Unit of Academic Radiology, Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom.
authors.forename: Madhwesha
authors.initials: M
authors.lastname: Rao
authors.affiliation: POLARIS, Unit of Academic Radiology, Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom.
authors.forename: Neil J
authors.initials: NJ
authors.lastname: Stewart
authors.affiliation: POLARIS, Unit of Academic Radiology, Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom.|Insigneo Institute of In-Silico Medicine, University of Sheffield, Sheffield, United Kingdom.
authors.forename: Jim M
authors.initials: JM
authors.lastname: Wild
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D005260:Female; D006371:Helium / Q000493:pharmacokinetics*; D006801:Humans; D007554:Isotopes / Q000493:pharmacokinetics*; D008168:Lung / Q000000981:diagnostic imaging* / Q000378:metabolism*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008657:Metabolic Clearance Rate; D011659:Pulmonary Gas Exchange / Q000502:physiology*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D015656:Respiratory Mechanics; D012815:Signal Processing, Computer-Assisted; D014979:Xenon Isotopes / Q000493:pharmacokinetics*; D055815:Young Adult
chemical_list: D007554:Isotopes; D019275:Radiopharmaceuticals; D014979:Xenon Isotopes; C000614971:Xenon-129; D006371:Helium; C000615206:Helium-3
keywords: 129Xe; 3He; hyperpolarized gas; lung function; multiple breath washout