title: Design, synthesis, and in vitro antimicrobial activity of hydrazide-hydrazones of 2-substituted acetic acid.
abstract: In this study, 30 hydrazide-hydrazones of phenylacetic (3-10) and hydroxyacetic acid (11-32) were synthesized by the condensation reaction of appropriate 2-substituted acetic acid hydrazide with different aromatic aldehydes. The obtained compounds were characterized by spectral data and evaluated in vitro for their potential antimicrobial activities against a panel of reference strains of micro-organisms, including Gram-positive bacteria, Gram-negative bacteria, and fungi belonging to the Candida spp. The results from our antimicrobial assays indicated that among synthesized compounds 3-32, especially compounds 6, 14, and 26 showed high bactericidal activity (MIC = 0.488-7.81 μg/ml) against reference Gram-positive bacteria, and in some cases, their activity was even better than that of commonly used antibiotics, such as cefuroxime or ampicillin.
authors.affiliation: Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Lublin, Lublin, Poland. lukasz.popiolek@umlub.pl.
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Popiołek
authors.affiliation: Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Medical University of Lublin, Lublin, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Biernasiuk
mesh_terms: D019342:Acetic Acid / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001386:Azides / Q000737:chemistry / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D015195:Drug Design; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006835:Hydrazones / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D066244:Proton Magnetic Resonance Spectroscopy
chemical_list: D000890:Anti-Infective Agents; D001386:Azides; D006835:Hydrazones; D019342:Acetic Acid
keywords: 
  MBC
  ; 
  MIC
  ; Antimicrobial activity; Gram-positive bacteria; hydrazide-hydrazones