title: "Janus" Calixarenes: Double-Sided Molecular Linkers for Facile, Multianchor Point, Multifunctional, Surface Modification.
abstract: We herein report the synthesis of novel "Janus" calix[4]arenes bearing four "molecular tethering" functional groups on either the upper or lower rims of the calixarene. These enable facile multipoint covalent attachment to electrode surfaces with monolayer coverage. The other rim of the calixarenes bear either four azide or four ethynyl functional groups, which are easily modified by the copper(I)-catalyzed azide-alkyne cycloaddition reaction (CuAAC), either pre- or postsurface modification, enabling these conical, nanocavity reactor sites to be decorated with a wide range of substrates to impart desired chemical properties. Redox active species decorating the peripheral rim are shown to be electrically connected by the calixarene to the electrode surface in either "up" or "down" orientations of the calixarene.
authors.affiliation: School of Chemistry, University of East Anglia , Norwich Research Park, Norwich NR4 7TJ, United Kingdom.
authors.forename: James P
authors.initials: JP
authors.lastname: Buttress
authors.affiliation: School of Chemistry, University of East Anglia , Norwich Research Park, Norwich NR4 7TJ, United Kingdom.
authors.forename: David P
authors.initials: DP
authors.lastname: Day
authors.affiliation: School of Chemistry, University of East Anglia , Norwich Research Park, Norwich NR4 7TJ, United Kingdom.
authors.forename: James M
authors.initials: JM
authors.lastname: Courtney
authors.affiliation: School of Chemistry, University of East Anglia , Norwich Research Park, Norwich NR4 7TJ, United Kingdom.
authors.forename: Elliot J
authors.initials: EJ
authors.lastname: Lawrence
authors.affiliation: School of Chemistry, University of East Anglia , Norwich Research Park, Norwich NR4 7TJ, United Kingdom.
authors.forename: David L
authors.initials: DL
authors.lastname: Hughes
authors.affiliation: School of Chemistry, University of East Anglia , Norwich Research Park, Norwich NR4 7TJ, United Kingdom.
authors.forename: Robin J
authors.initials: RJ
authors.lastname: Blagg
authors.affiliation: Oxford University Begbroke Science Park , Begbroke Hill, Oxford, OX5 1PF, United Kingdom.
authors.forename: Alison
authors.initials: A
authors.lastname: Crossley
authors.affiliation: School of Pharmacy, University of East Anglia , Norwich Research Park, Norwich NR4 7TJ, United Kingdom.
authors.forename: Susan E
authors.initials: SE
authors.lastname: Matthews
authors.affiliation: Department of Chemistry, University of Hull , Cottingham Road, Hull, HU6 7RX, United Kingdom.
authors.forename: Carl
authors.initials: C
authors.lastname: Redshaw
authors.affiliation: School of Chemistry, University of East Anglia , Norwich Research Park, Norwich NR4 7TJ, United Kingdom.
authors.forename: Philip C
authors.initials: PC
authors.lastname: Bulman Page
authors.affiliation: School of Chemistry, University of East Anglia , Norwich Research Park, Norwich NR4 7TJ, United Kingdom.
authors.forename: Gregory G
authors.initials: GG
authors.lastname: Wildgoose