title: Programmed cell death acts at different stages of Drosophila neurodevelopment to shape the central nervous system.
abstract: Nervous system development is a process that integrates cell proliferation, differentiation, and programmed cell death (PCD). PCD is an evolutionary conserved mechanism and a fundamental developmental process by which the final cell number in a nervous system is established. In vertebrates and invertebrates, PCD can be determined intrinsically by cell lineage and age, as well as extrinsically by nutritional, metabolic, and hormonal states. Drosophila has been an instrumental model for understanding how this mechanism is regulated. We review the role of PCD in Drosophila central nervous system development from neural progenitors to neurons, its molecular mechanism and function, how it is regulated and implemented, and how it ultimately shapes the fly central nervous system from the embryo to the adult. Finally, we discuss ideas that emerged while integrating this information.
authors.affiliation: Department of Biology, New York University 1009 Silver Center 100 Washington Square East, New York, NY 10003, USA.|Center for Genomics and Systems Biology, New York University Abu Dhabi, Abu Dhabi 129188, UAE.
authors.forename: Filipe
authors.initials: F
authors.lastname: Pinto-Teixeira
authors.affiliation: Department of Biology, New York University 1009 Silver Center 100 Washington Square East, New York, NY 10003, USA.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Konstantinides
authors.affiliation: Department of Biology, New York University 1009 Silver Center 100 Washington Square East, New York, NY 10003, USA.|Center for Genomics and Systems Biology, New York University Abu Dhabi, Abu Dhabi 129188, UAE.
authors.forename: Claude
authors.initials: C
authors.lastname: Desplan
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D002454:Cell Differentiation / Q000235:genetics*; D019070:Cell Lineage / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics; D002490:Central Nervous System / Q000254:growth & development* / Q000378:metabolism; D004330:Drosophila / Q000235:genetics* / Q000254:growth & development; D009474:Neurons / Q000378:metabolism
keywords: Drosophila; apoptosis; neurodevelopment