title: The Current Weight of Evidence of the Microbiologic Profile Associated With Peri-Implantitis: A Systematic Review.
abstract: There is currently no consensus regarding microorganisms that may be considered true peri-implant pathogens. Therefore, the aim of this systematic review is to determine the weight of evidence for microorganisms related to peri-implantitis based on results of association studies.
  
  
  
  This review was performed following the Preferred Reporting Items for Systematic Reviews and MetaAnalyses (PRISMA). Two independent researchers searched PubMed/Medline, Embase, and Cochrane Library databases up to August 4, 2015, for studies comparing microbiologic outcomes of subgingival biofilm samples from healthy implants and implants with peri-implantitis.
  
  
  
  A total of 799 titles was identified and 11 studies were included in this review. All data were extracted using a predefined form. Microorganisms found in increased count/abundance/frequency in peri-implantitis belonged to Bacteria domain and viruses, and included a total of six bacterial phyla, 17 bacterial genera, 23 bacterial species, and two genera of viruses. The main bacterial species associated with peri-implantitis are recognized as periodontal pathogens.
  
  
  
  Results of this systematic review suggest moderate evidence supporting association of Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia and some evidence supporting association of Prevotella intermedia and Campylobacter rectus with the etiology of peri-implantitis.
authors.affiliation: Dental Research Division, Department of Periodontology, Guarulhos University, Guarulhos, São Paulo, Brazil.
authors.forename: Paula Juliana
authors.initials: PJ
authors.lastname: Pérez-Chaparro
authors.affiliation: Dental Research Division, Department of Periodontology, Guarulhos University, Guarulhos, São Paulo, Brazil.
authors.forename: Poliana Mendes
authors.initials: PM
authors.lastname: Duarte
authors.affiliation: Dental Research Division, Department of Periodontology, Guarulhos University, Guarulhos, São Paulo, Brazil.
authors.forename: Jamil Awad
authors.initials: JA
authors.lastname: Shibli
authors.affiliation: Dental Research Division, Department of Periodontology, Guarulhos University, Guarulhos, São Paulo, Brazil.
authors.forename: Sheyla
authors.initials: S
authors.lastname: Montenegro
authors.affiliation: Dental Research Division, Department of Periodontology, Guarulhos University, Guarulhos, São Paulo, Brazil.
authors.forename: Sílvia
authors.initials: S
authors.lastname: Lacerda Heluy
authors.affiliation: Dental Research Division, Department of Periodontology, Guarulhos University, Guarulhos, São Paulo, Brazil.
authors.forename: Luciene Cristina
authors.initials: LC
authors.lastname: Figueiredo
authors.affiliation: Dental Research Division, Department of Periodontology, Guarulhos University, Guarulhos, São Paulo, Brazil.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Faveri
authors.affiliation: Dental Research Division, Department of Periodontology, Guarulhos University, Guarulhos, São Paulo, Brazil.
authors.forename: Magda
authors.initials: M
authors.lastname: Feres
mesh_terms: D015921:Dental Implants; D006801:Humans; D057873:Peri-Implantitis / Q000382:microbiology*; D016966:Porphyromonas gingivalis; D018713:Prevotella intermedia; D048373:Treponema denticola
chemical_list: D015921:Dental Implants
keywords: Dental implants; microbiology; osseointegration; peri-implantitis