title: Advances in genetics: widening our understanding of prostate cancer.
abstract: Prostate cancer is a leading cause of cancer-related death in Western men. Our understanding of the genetic alterations associated with disease predisposition, development, progression, and therapy response is rapidly improving, at least in part, owing to the development of next-generation sequencing technologies. Large advances have been made in our understanding of the genetics of prostate cancer through the application of whole-exome sequencing, and this review summarises recent advances in this field and discusses how exome sequencing could be used clinically to promote personalised medicine for prostate cancer patients.
authors.affiliation: Molecular Oncology, School of Biological Sciences, University of Essex, Colchester, Essex, UK.
authors.forename: Angela C
authors.initials: AC
authors.lastname: Pine
authors.affiliation: Androgen Signalling Laboratory, Division of Cancer, Department of Surgery and Cancer, Imperial Centre for Translational & Experimental Medicine, Imperial College London, London, UK.
authors.forename: Flavia F
authors.initials: FF
authors.lastname: Fioretti
authors.affiliation: Molecular Oncology, School of Biological Sciences, University of Essex, Colchester, Essex, UK; Androgen Signalling Laboratory, Division of Cancer, Department of Surgery and Cancer, Imperial Centre for Translational & Experimental Medicine, Imperial College London, London, UK.
authors.forename: Greg N
authors.initials: GN
authors.lastname: Brooke
authors.affiliation: Androgen Signalling Laboratory, Division of Cancer, Department of Surgery and Cancer, Imperial Centre for Translational & Experimental Medicine, Imperial College London, London, UK.
authors.forename: Charlotte L
authors.initials: CL
authors.lastname: Bevan
keywords: Androgen; Cancer progression; DNA damage repair; Metastasis; Personalised Medicine; Prostate Cancer; Transcriptome; WES; Whole Exome Sequencing