title: Biotransformation of Resveratrol: New Prenylated trans-Resveratrol Synthesized by Aspergillus sp. SCSIOW2.
abstract: Arahypin-16 (1), a new prenylated resveratrol with a unique dihydrobenzofuran ring, has been isolated as a microbial metabolite of resveratrol (2) from whole-cell fermentation of Aspergillus sp. SCSIOW2. The stereochemistry of 1 was determined by ECD calculations. 1 showed about half of the extracellular radical scavenging effect (IC50 = 161.4 μM) compared with resveratrol (IC50 = 80.5 μM), while on biomembranes it exhibited the same range of protection effects against free radicals generated from AAPH (IC50 = 78.6 μM and 87.9 μM).
authors.affiliation: Shenzhen Key Laboratory of Marine Bioresource and Eco-environmental Science, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China. lwang@szu.edu.cn.|Shenzhen Key Laboratory of Microbial Genetic Engineering, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China. lwang@szu.edu.cn.
authors.forename: Liyan
authors.initials: L
authors.lastname: Wang
authors.affiliation: Shenzhen Key Laboratory of Marine Bioresource and Eco-environmental Science, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China. 13723776301@139.com.|Shenzhen Key Laboratory of Microbial Genetic Engineering, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China. 13723776301@139.com.
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Shenzhen Key Laboratory of Marine Bioresource and Eco-environmental Science, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China. cyto2011@126.com.|Shenzhen Key Laboratory of Microbial Genetic Engineering, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China. cyto2011@126.com.
authors.forename: Yongtao
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Shenzhen Key Laboratory of Marine Bioresource and Eco-environmental Science, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China. 13691608828@163.com.|Shenzhen Key Laboratory of Microbial Genetic Engineering, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China. 13691608828@163.com.
authors.forename: Jiaxin
authors.initials: J
authors.lastname: Zou
authors.affiliation: Shenzhen Key Laboratory of Marine Bioresource and Eco-environmental Science, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China. lixiaof@szu.edu.cn.|Shenzhen Key Laboratory of Microbial Genetic Engineering, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China. lixiaof@szu.edu.cn.
authors.forename: Xiaofan
authors.initials: X
authors.lastname: Li
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D001230:Aspergillus / Q000378:metabolism*; D001711:Biotransformation; D002942:Circular Dichroism; D004910:Erythrocyte Membrane / Q000187:drug effects; D005609:Free Radicals / Q000037:antagonists & inhibitors; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011817:Rabbits; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D005609:Free Radicals; D013267:Stilbenes; D000077185:Resveratrol
keywords: Aspergillus sp. SCSIOW2; DPPH scavenging activity; ECD; erythrocyte protection activity; prenylation; resveratrol