title: [Polycystic ovary sindrome: impact on reproductive and maternal fetal health].
abstract: Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism (H), oligo-anovulation (O) and / or polycystic ovaries (P). There is currently little information on perinatal complications.
  
  
  
  to investigate obstetric and neonatal characteristics of women with PCOS in our population.
  
  
  
  we studied 87 pregnant women with PCOS (categorized in four phenotypes according Rotterdam Consensus: A (H + O + P) n = 53; B (H + O) n = 9; C (H + P) n = 16 and D (O + P) n = 9) and 96 without PCOS (control). We analyzed clinical and biochemical features (age, anthropometry hirsutism, acanthosis nigricans, OGTT, insulin, lipid profile, androgen and gonadotropins) during preconception, (weight gain, blood pressure, OGTT) through gestation and occurrence of perinatal complications.
  
  
  
  we found no differences in age (29.4 ± 4 and 28.7 ± 5 years) and body mass index (28.2 ± 6 and 27.8 ± 6 kg / m2) in both groups; while patients with PCOS had higher waist circumference, blood pressure and acanthosis nigricans versus control. Despite similar weight gain, patients with PCOS had higher percentage of perinatal complications. In the A phenotype RR for perinatal adverse outcomes was 2.37 (95%CI: 1.67-3.36, p <0.001). The HOMA-IR index preconception and fasting glucose during pregnancy were the predictors for these complications (p=0.01).
  
  
  
  patients with PCOS have a higher risk for complications during pregnancy and newborns more frequently have low weight or macrosomy. A careful history can recognize patients with higher perinatal risk to develop complications.
authors.affiliation: Dpto de Endocrinología y Diabetes Hospital Universitario de Maternidad y Neonatología de Córdoba. Facultad de Ciencias Médicas. Universidad Nacional de Córdoba. Córdoba. Argentina.
authors.forename: Carolina
authors.initials: C
authors.lastname: Fux Otta
authors.affiliation: Instituto Universitario de medicina Reproductiva (IUMER). Facultad de Ciencias Médicas. Universidad Nacional de Córdona. Córdoba - argentina.
authors.forename: Gabriel Santino
authors.initials: GS
authors.lastname: Iraci
authors.affiliation: Cátedra de Farmacología Aplicada. Hospital Nacional de Clínicas. Facultad de Ciencias Médicas. Universidad Nacional de Córdoba. Córdoba. Argentina.
authors.forename: Paula
authors.initials: P
authors.lastname: Szafryk de Mereshian
authors.affiliation: Cátedra de Fisiología Humana. Laboratorio de Reproducción. Facultad de Ciencias Médicas. Universidad Nacional de Córdoba. Córdoba. Argentina.
authors.forename: Marta
authors.initials: M
authors.lastname: Fiol de Cuneo
mesh_terms: D000293:Adolescent; D000328:Adult; D000886:Anthropometry; D016022:Case-Control Studies; D005260:Female; D005315:Fetal Diseases / Q000209:etiology; D005333:Fetus; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000209:etiology; D010641:Phenotype; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000503:physiopathology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology* / Q000503:physiopathology; D011256:Pregnancy Outcome; D012307:Risk Factors; D055815:Young Adult