title: Perinatal triphenyl phosphate exposure accelerates type 2 diabetes onset and increases adipose accumulation in UCD-type 2 diabetes mellitus rats.
abstract: Triphenyl phosphate (TPhP) is a flame retardant additive frequently found in consumer products and household dust. We administered 170μg of TPhP in maternal food from gestational day 8.5 to weaning and evaluated metabolic phenotypes of 3.5 month old male and female rats, and weight-matched males up to 6 months, to assess the development of obesity and type 2 diabetes mellitus (T2DM), respectively. Perinatal TPhP exposure increased body and fat mass in 3.5 month old male and female rats, while leptin and cumulative energy intake were elevated in males and females, respectively. Independent of body mass, perinatal TPhP exposure accelerated T2DM onset in males and increased plasma non-esterified- fasting fatty acids. These observations suggest that perinatal exposure to TPhP exacerbates the development of obesity in male and female UCDavis-T2DM rats and accelerates T2DM onset in male UCD-T2DM rats.
authors.affiliation: Department of Environmental Toxicology, University of California at Davis, Davis, CA, USA.
authors.forename: Adrian J
authors.initials: AJ
authors.lastname: Green
authors.affiliation: Department of Nutrition, University of California at Davis, Davis, CA, USA.
authors.forename: James L
authors.initials: JL
authors.lastname: Graham
authors.affiliation: Department of Environmental Toxicology, University of California at Davis, Davis, CA, USA.
authors.forename: Eduardo A
authors.initials: EA
authors.lastname: Gonzalez
authors.affiliation: Department of Nutrition, University of California at Davis, Davis, CA, USA; West Coast Metabolomics Center, University of California at Davis, Davis, CA, USA.
authors.forename: Michael R
authors.initials: MR
authors.lastname: La Frano
authors.affiliation: Department of Toxic Substances Control, California Environmental Protection Agency, Berkeley, CA, USA.
authors.forename: Syrago-Styliani E
authors.initials: SE
authors.lastname: Petropoulou
authors.affiliation: Department of Toxic Substances Control, California Environmental Protection Agency, Berkeley, CA, USA.
authors.forename: June-Soo
authors.initials: JS
authors.lastname: Park
authors.affiliation: Department of Nutrition, University of California at Davis, Davis, CA, USA; West Coast Metabolomics Center, University of California at Davis, Davis, CA, USA; Obesity and Metabolism Research Unit, USDA-ARS Western Human Nutrition Research Center, Davis, CA, USA.
authors.forename: John W
authors.initials: JW
authors.lastname: Newman
authors.affiliation: Department of Nutrition, University of California at Davis, Davis, CA, USA; Department of Molecular Biosciences, School of Veterinary Medicine, University of California at Davis, Davis, CA, USA.
authors.forename: Kimber L
authors.initials: KL
authors.lastname: Stanhope
authors.affiliation: Department of Nutrition, University of California at Davis, Davis, CA, USA; Department of Molecular Biosciences, School of Veterinary Medicine, University of California at Davis, Davis, CA, USA.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Havel
authors.affiliation: Department of Environmental Toxicology, University of California at Davis, Davis, CA, USA. Electronic address: mlamerrill@ucdavis.edu.
authors.forename: Michele A
authors.initials: MA
authors.lastname: La Merrill
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced* / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000139:chemically induced* / Q000378:metabolism; D004785:Environmental Pollutants / Q000633:toxicity* / Q000652:urine; D005260:Female; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects; D010755:Organophosphates / Q000633:toxicity* / Q000652:urine; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced* / Q000378:metabolism; D051381:Rats
chemical_list: D001786:Blood Glucose; D004785:Environmental Pollutants; D010755:Organophosphates; C005445:triphenyl phosphate
keywords: Developmental exposure; Diabetes mellitus; Firemaster 550; Hyperphagia; Leptin; Obesity; Triphenyl phosphate