title: Progesterone induces the expression of lipocalin-2 through Akt-c-Myc pathway during mouse decidualization.
abstract: Lipocalin-2 (Lcn2) is a small glycoprotein involved in a number of biological processes such as inflammation and antibacterial response. In our study, Lcn2 is expressed in the subluminal stromal cells at implantation site on day 5 of pregnancy. The expression of Lcn2 in stromal cells is under the control of progesterone through Akt-c-Myc signaling pathway. Data from Lcn2 knockdown and recombinant protein treatments indicate that Lcn2 promotes mPGES-1 expression in stromal cells. The expression of Lcn2 and mPGES-1 is strongly stimulated by lipopolysaccharide (LPS), indicating that Lcn2 mediates LPS-induced inflammation. These findings shed light on the role of Lcn2 during decidualization.
authors.affiliation: College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
authors.forename: Yue-Fang
authors.initials: YF
authors.lastname: Liu
authors.affiliation: College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
authors.forename: Wen-Bo
authors.initials: WB
authors.lastname: Deng
authors.affiliation: College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
authors.forename: Shu-Yun
authors.initials: SY
authors.lastname: Li
authors.affiliation: College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
authors.forename: Mei-Nan
authors.initials: MN
authors.lastname: Yao
authors.affiliation: Department of Biology, Shantou University, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.affiliation: College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
authors.forename: Hai-Tin
authors.initials: HT
authors.lastname: Dou
authors.affiliation: College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
authors.forename: Meng-Long
authors.initials: ML
authors.lastname: Zhao
authors.affiliation: College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
authors.forename: Zeng-Ming
authors.initials: ZM
authors.lastname: Yang
authors.affiliation: College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
authors.forename: Xiao-Huan
authors.initials: XH
authors.lastname: Liang
mesh_terms: D000818:Animals; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects; D055785:Gene Knockdown Techniques; D007249:Inflammation / Q000139:chemically induced / Q000235:genetics* / Q000378:metabolism; D000071068:Lipocalin-2 / Q000096:biosynthesis / Q000235:genetics*; D008070:Lipopolysaccharides / Q000633:toxicity; D051379:Mice; D011247:Pregnancy; D011374:Progesterone / Q000378:metabolism*; D000071876:Prostaglandin-E Synthases / Q000096:biosynthesis* / Q000235:genetics; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics; D015398:Signal Transduction / Q000187:drug effects; D017154:Stromal Cells / Q000187:drug effects / Q000378:metabolism
chemical_list: D000071068:Lipocalin-2; D008070:Lipopolysaccharides; D016271:Proto-Oncogene Proteins c-myc; D011374:Progesterone; D051057:Proto-Oncogene Proteins c-akt; D000071876:Prostaglandin-E Synthases; C000605866:Ptges2 protein, mouse
keywords: implantation; lipocalin-2; mPGES-1; mouse; uterus