title: Roles of microRNA-221/222 in type 2 diabetic patients with post-menopausal breast cancer.
abstract: The aim of the research was to examine the expression level of microRNA221/222 (miR-221/222) in the serum of patients with type 2 diabetes mellitus (T2DM) who are also diagnosed with post-menopausal breast cancer. We aimed to evaluate the differences in microRNA expression in patients with T2DM alone, patients with post-menopausal breast cancer alone, and patients with both T2DM and post-menopausal breast cancer. We selected 20 cases from a healthy control group, 30 cases from the group of patients with T2DM and obesity, 30 cases from the group of the patients with post-menopausal breast cancer, and 30 cases from the group of patients with both T2DM and post-menopausal breast cancer. The expression of miR-221/222 in the serum of the patients with post-menopausal breast cancer was higher than that of T2DM patients (P < 0.05), but lower than that of the T2DM patients who were also positive for post-menopausal breast cancer (P < 0.05); the expression of miR-221/222 in the serum of the T2DM patients was higher than that of the healthy controls (P < 0.05). BMI, HOMA-IR, HbA1c, and TG were positively correlated with the relative expression of miR-221/222 in the serum (P < 0.01). In conclusion, miR-221/222 participates in insulin resistance; the combination of miR- 221/222 and estrogen contributes to incidence of T2DM with post-menopausal breast cancer complications. MiR-221/222 may participate in the occurrence and progression of T2DM with post-menopausal breast cancer via down-regulation of CAVl.
authors.affiliation: Department of General Surgery, People's Hospital, Binzhou, Shandong, China.
authors.forename: M Y
authors.initials: MY
authors.lastname: Li
authors.affiliation: Department of Medical Gastroenterology, People's Hospital, Binzhou, Shandong, China.
authors.forename: S R
authors.initials: SR
authors.lastname: Pan
authors.affiliation: Department of General Surgery, People's Hospital, Binzhou, Shandong, China.
authors.forename: A Y
authors.initials: AY
authors.lastname: Qiu
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D001943:Breast Neoplasms / Q000097:blood / Q000150:complications / Q000235:genetics*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000235:genetics*; D015536:Down-Regulation; D005260:Female; D015870:Gene Expression; D006801:Humans; D007333:Insulin Resistance; D035683:MicroRNAs / Q000096:biosynthesis* / Q000097:blood / Q000235:genetics; D008875:Middle Aged; D009765:Obesity / Q000097:blood; D017698:Postmenopause / Q000502:physiology
chemical_list: D001786:Blood Glucose; D035683:MicroRNAs; C525709:MIR221, human; C525710:MIR222, human