title: Electrochemical Sensor Based on Fe Doped Hydroxyapatite-Carbon Nanotubes Composite for L-Dopa Detection in the Presence of Uric Acid.
abstract: A novel amperometric sensor based on iron doped hydroxyapatite (Fe-HA) and multiwalled carbon nanotubes (CNT) composite immobilized on a glassy carbon electrode (GCE) has been fabricated. The hybrid composite made of Fe-HA nanoparticles and CNT promotes electron transfer kinetics between the analyte levodopa (L-dopa) and the modified GC electrode. Under optimum conditions, the fabricated sensor gave a linear response range of 1.0 x 10(-7)-1.1 x 10(-6) M with the detection limit as low as 62 nM. The Fe-HA/CNT modified electrode showed good selectivity towards the determination of L-dopa in the presence of ascorbic acid (AA), uric acid (UA) and other common interferents. The sensor displays a high sensitivity, good reproducibility and long-term stability and it was successfully applied for the detection of L-dopa in pharmaceutical and medicinal plant samples.
authors.forename: P
authors.initials: P
authors.lastname: Kanchana
authors.forename: S
authors.initials: S
authors.lastname: Radhakrishnan
authors.forename: M
authors.initials: M
authors.lastname: Navaneethan
authors.forename: M
authors.initials: M
authors.lastname: Arivanandhan
authors.forename: Y
authors.initials: Y
authors.lastname: Hayakawa
authors.forename: C
authors.initials: C
authors.lastname: Sekar
mesh_terms: D002384:Catalysis; D017886:Durapatite / Q000737:chemistry*; D004563:Electrochemistry / Q000295:instrumentation*; D004566:Electrodes; D005898:Glass / Q000737:chemistry; D007501:Iron / Q000737:chemistry*; D007980:Levodopa / Q000032:analysis* / Q000737:chemistry; D057230:Limit of Detection; D031299:Mucuna / Q000737:chemistry; D037742:Nanotubes, Carbon / Q000737:chemistry*; D010084:Oxidation-Reduction; D014527:Uric Acid / Q000737:chemistry*
chemical_list: D037742:Nanotubes, Carbon; D014527:Uric Acid; D007980:Levodopa; D017886:Durapatite; D007501:Iron