title: Potential therapeutic targets and the role of technology in developing novel cannabinoid drugs from cyanobacteria.
abstract: Cyanobacteria find several applications in pharmacology as potential candidates for drug design. The need for new compounds that can be used as drugs has always been on the rise in therapeutics. Cyanobacteria have been identified as promising targets of research in the quest for new pharmaceutical compounds as they can produce secondary metabolites with novel chemical structures. Cyanobacteria is now recognized as a vital source of bioactive molecules like Curacin A, Largazole and Apratoxin which have succeeded in reaching Phase II and Phase III into clinical trials. The discovery of several new clinical cannabinoid drugs in the past decade from diverse marine life should translate into a number of new drugs for cannabinoid in the years to come. Conventional cannabinoid drugs have high toxicity and as a result, they affect the efficacy of chemotherapy and patients' life very much. The present review focuses on how potential, safe and affordable drugs used for cannabinoid treatment could be developed from cyanobacteria.
authors.affiliation: Computational Phytochemistry Lab, P.G. and Research Department of Botany and Microbiology, A.V.V.M. Sri Pushpam College (Autonomous), Poondi-613 503, Thanjavur district, Tamil Nadu 613 503, India. Electronic address: svijaya_kumar2579@rediff.com.
authors.forename: S
authors.initials: S
authors.lastname: Vijayakumar
authors.affiliation: Computational Phytochemistry Lab, P.G. and Research Department of Botany and Microbiology, A.V.V.M. Sri Pushpam College (Autonomous), Poondi-613 503, Thanjavur district, Tamil Nadu 613 503, India.
authors.forename: P
authors.initials: P
authors.lastname: Manogar
authors.affiliation: Computational Phytochemistry Lab, P.G. and Research Department of Botany and Microbiology, A.V.V.M. Sri Pushpam College (Autonomous), Poondi-613 503, Thanjavur district, Tamil Nadu 613 503, India.
authors.forename: S
authors.initials: S
authors.lastname: Prabhu
mesh_terms: D020811:Biomedical Technology / Q000379:methods*; D002186:Cannabinoids / Q000737:chemistry / Q000378:metabolism*; D000458:Cyanobacteria / Q000378:metabolism*; D015195:Drug Design; D058990:Molecular Targeted Therapy; D043882:Receptors, Cannabinoid / Q000378:metabolism
chemical_list: D002186:Cannabinoids; D043882:Receptors, Cannabinoid
keywords: CB1 & CB2; Computational approach; Cyanobacteria; Secondary metabolites