title: Enantioselective Ethylation of Various Aldehydes Catalyzed by Readily Accessible Chiral Diols.
abstract: Four chiral C2 -symmetric diols were synthesized in a straightforward three-step reaction and demonstrated excellent enantioselectivities and good overall yields. Their catalytic activities were examined via the addition of diethylzinc to various aldehydes. The enantioselective addition of diethylzinc to 2-methoxybenzaldehyde gave the corresponding chiral secondary alcohol with high yields (up to 95%) and moderate to good enantiomeric excess (up to 88%). All synthesized ligands were evaluated in the addition of diethylzinc to various aldehydes in the presence of an additional metal such as Ti(IV) complexes. Chirality 28:593-598, 2016. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Department of Chemistry, Faculty of Arts and Sciences, Osmaniye Korkut Ata University, Osmaniye, Turkey.
authors.forename: Yaşar
authors.initials: Y
authors.lastname: Gök
authors.affiliation: Department of Chemistry, Faculty of Arts and Sciences, Osmaniye Korkut Ata University, Osmaniye, Turkey.
authors.forename: Seda
authors.initials: S
authors.lastname: Kiliçarslan
authors.affiliation: Department of Chemistry, Faculty of Arts and Sciences, Osmaniye Korkut Ata University, Osmaniye, Turkey.
authors.forename: Halil Zeki
authors.initials: HZ
authors.lastname: Gök
authors.affiliation: Department of Chemistry, Faculty of Arts and Sciences, Osmaniye Korkut Ata University, Osmaniye, Turkey.
authors.forename: İlker Ümit
authors.initials: İÜ
authors.lastname: Karayiğit
keywords: C2-symmetric; catalysis; chiral diols; diethylzinc addition; enantioselectivity