title: Switching Lopinavir/Ritonavir to Atazanavir/Ritonavir vs Adding Atorvastatin in HIV-Infected Patients Receiving Second-Line Antiretroviral Therapy With Hypercholesterolemia: A Randomized Controlled Trial.
abstract: A randomized controlled trial was conducted among human immunodeficiency virus-infected patients receiving lopinavir/ritonavir-based regimens with hypercholesterolemia. Reduction of total cholesterol and low-density lipoprotein was significantly greater in patients who were randomized to the addition of atorvastatin compared with those who were switched from lopinavir/ritonavir to atazanavir/ritonavir.
authors.affiliation: Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: Phanthaboon
authors.initials: P
authors.lastname: Wangpatharawanit
authors.affiliation: Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: Somnuek
authors.initials: S
authors.lastname: Sungkanuparph
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D000069446:Atazanavir Sulfate / Q000627:therapeutic use; D000069059:Atorvastatin / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications / Q000453:epidemiology; D008077:Lipoproteins, LDL / Q000097:blood; D061466:Lopinavir / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D019438:Ritonavir / Q000627:therapeutic use
chemical_list: D019380:Anti-HIV Agents; D008077:Lipoproteins, LDL; D061466:Lopinavir; D000069446:Atazanavir Sulfate; D002784:Cholesterol; D000069059:Atorvastatin; D019438:Ritonavir
keywords: atazanavir; atorvastatin; hypercholesterolemia; lopinavir; randomized controlled trial