title: Synthesis of 5-Amino-2,5-dihydro-1H-benzo[b]azepines Using a One-Pot Multibond Forming Process.
abstract: Rapid access to allylic trichloroacetimidates bearing a 2-allylaminoaryl group from readily available 2-iodoanilines combined with a one-pot multibond forming process has allowed the efficient synthesis of a series of 5-amino-2,5-dihydro-1H-benzo[b]azepines. The potential of these compounds as synthetic building blocks was demonstrated by the preparation of a late-stage intermediate of the hyponatremia agent, mozavaptan.
authors.affiliation: WestCHEM, School of Chemistry, The Joseph Black Building, University of Glasgow , Glasgow G12 8QQ, United Kingdom.
authors.forename: Salaheddin A I
authors.initials: SA
authors.lastname: Sharif
authors.affiliation: WestCHEM, School of Chemistry, The Joseph Black Building, University of Glasgow , Glasgow G12 8QQ, United Kingdom.
authors.forename: Ewen D D
authors.initials: ED
authors.lastname: Calder
authors.affiliation: WestCHEM, School of Chemistry, The Joseph Black Building, University of Glasgow , Glasgow G12 8QQ, United Kingdom.
authors.forename: Fábio G
authors.initials: FG
authors.lastname: Delolo
authors.affiliation: WestCHEM, School of Chemistry, The Joseph Black Building, University of Glasgow , Glasgow G12 8QQ, United Kingdom.
authors.forename: Andrew
authors.initials: A
authors.lastname: Sutherland