title: Intravascular large B-cell lymphoma with a high titer of proteinase-3-anti-neutrophil cytoplasmic antibody mimicking granulomatosis with polyangiitis.
abstract: A 63-year-old man presented with fever, sinusitis, otitis, and high titers of proteinase-3 anti-neutrophil cytoplasmic antibody (PR3-ANCA). Granulomatosis with polyangiitis (GPA) was first suspected. However, nasal mucosa and skin biopsies revealed the presence of intravascular large B-cell lymphoma (IVLBCL). We present a rare case of IVLBCL with a high titer of PR3-ANCA mimicking GPA.
authors.affiliation: a Department of Clinical Immunology and Rheumatology , the Tazuke-Kofukai Medical Research Institute, Kitano Hospital , Osaka , Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Shinkawa
authors.affiliation: a Department of Clinical Immunology and Rheumatology , the Tazuke-Kofukai Medical Research Institute, Kitano Hospital , Osaka , Japan.
authors.forename: Saori
authors.initials: S
authors.lastname: Hatachi
authors.affiliation: a Department of Clinical Immunology and Rheumatology , the Tazuke-Kofukai Medical Research Institute, Kitano Hospital , Osaka , Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Yagita
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology*; D003937:Diagnosis, Differential; D014890:Granulomatosis with Polyangiitis / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D053146:Myeloblastin / Q000276:immunology*
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D053146:Myeloblastin
keywords: ANCA-associated vasculitis; Intravascular large B-cell lymphoma; Proteinase-3 anti-neutrophil cytoplasmic antibody