title: Two new quinones from the roots of Juglans mandshurica.
abstract: Two new quinones, 1-hydroxy-5-pentyl-anthraquinone (1) and 4-(5-hydroxy-1,4-dioxo-1,4-dihydro-naphthalen-2-ylamino)-butyric acid methyl ester (2), together with two known quinones, 5-hydroxy-2-(2-hydroxy-ethylamino)-(1,4) naphthoquinone (3) and juglone (4) were isolated from the roots of Juglans mandshurica (Juglandaceae). Their structures were elucidated on the basis of spectral data. Compound 3 was isolated from the Juglans genus for the first time. Compounds 1-4 exhibited significant cytotoxicity towards cultured MDA-MB231, HepG2 and SNU638 cells with IC50 values ranging from 4.46 to 88.47 μM.
authors.affiliation: Key Laboratory of Natural Resources of the Changbai Mountain and Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji, 133002, People's Republic of China.|Department of Pharmacy, Yanbian University Hospital, Yanji, 133000, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Jin
authors.affiliation: Key Laboratory of Natural Resources of the Changbai Mountain and Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji, 133002, People's Republic of China.
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Sun
authors.affiliation: Department of Pharmacy, Yanbian University Hospital, Yanji, 133000, China.
authors.forename: Ren
authors.initials: R
authors.lastname: Li
authors.affiliation: Key Laboratory of Natural Resources of the Changbai Mountain and Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji, 133002, People's Republic of China.
authors.forename: Shengbao
authors.initials: S
authors.lastname: Diao
authors.affiliation: Key Laboratory of Natural Resources of the Changbai Mountain and Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji, 133002, People's Republic of China.
authors.forename: Changhao
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Natural Resources of the Changbai Mountain and Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji, 133002, People's Republic of China.
authors.forename: Jiongmo
authors.initials: J
authors.lastname: Cui
authors.affiliation: College of Pharmacy, Yeungnam University, Gyongsan, 712-749, Korea.
authors.forename: Jong-Keun
authors.initials: JK
authors.lastname: Son
authors.affiliation: Key Laboratory of Natural Resources of the Changbai Mountain and Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji, 133002, People's Republic of China. zw2015@ybu.edu.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhou
authors.affiliation: Key Laboratory of Natural Resources of the Changbai Mountain and Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji, 133002, People's Republic of China. gli@ybu.edu.cn.
authors.forename: Gao
authors.initials: G
authors.lastname: Li
mesh_terms: D056945:Hep G2 Cells; D006801:Humans; D031324:Juglans; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification*; D018517:Plant Roots; D011809:Quinones / Q000737:chemistry* / Q000302:isolation & purification*
chemical_list: D010936:Plant Extracts; D011809:Quinones
keywords: Cytotoxicity; Juglandaceae; Juglans mandshurica; Quinones