title: Applying the Fisher score to identify Alzheimer's disease-related genes.
abstract: Biologists and scientists can use the data from Alzheimer's disease (AD) gene expression microarrays to mine AD disease-related genes. Because of disadvantages such as small sample sizes, high dimensionality, and a high level of noise, it is difficult to obtain accurate and meaningful biological information from gene expression profiles. In this paper, we present a novel approach for utilizing AD microarray data to identify the morbigenous genes. The Fisher score, a classical feature selection method, is utilized to evaluate the importance of each gene. Genes with a large between-classes variance and small within-class variance are selected as candidate morbigenous genes. The results using an AD dataset show that the proposed approach is effective for gene selection. Satisfactory accuracy can be achieved by using only a small number of selected genes.
authors.affiliation: College of Computer Science, Sichuan Normal University, Chengdu, China.|Visual Computing and Virtual Reality Key Laboratory of Sichuan Province, Chengdu, China.
authors.forename: J
authors.initials: J
authors.lastname: Yang
authors.affiliation: College of Mathematics and Software, Sichuan Normal University, Chengdu, China.
authors.forename: Y L
authors.initials: YL
authors.lastname: Liu
authors.affiliation: College of Computer Science, Sichuan Normal University, Chengdu, China.
authors.forename: C S
authors.initials: CS
authors.lastname: Feng
authors.affiliation: College of Computer Science, Sichuan Normal University, Chengdu, China.
authors.forename: G Q
authors.initials: GQ
authors.lastname: Zhu
mesh_terms: D000465:Algorithms; D000544:Alzheimer Disease / Q000235:genetics*; D020869:Gene Expression Profiling; D053263:Gene Regulatory Networks; D006801:Humans; D008957:Models, Genetic