title: Unusual glycogenic hepatopathy causing abnormal liver enzymes in a morbidly obese adolescent with well-controlled type 2 diabetes: resolved after A1c was normalized by metformin.
abstract: We report, for the first time, a case of an accumulation of glycogen in the liver causing elevation of liver enzymes in a 15-year-old morbidly obese adolescent male with well-controlled type 2 diabetes. Notably, the patient did not have poorly controlled type 1 diabetes and did not require insulin. After normalization of the A1c with metformin, elevated liver enzymes returned to normal.
authors.affiliation: Department of Pediatrics, State University of New York (SUNY) Downstate Medical Center and Kings County Hospital Center, Brooklyn, NY, USA.
authors.forename: Vatcharapan
authors.initials: V
authors.lastname: Umpaichitra
mesh_terms: D000293:Adolescent; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D008107:Liver Diseases / Q000201:enzymology*; D008297:Male; D008687:Metformin / Q000008:administration & dosage / Q000627:therapeutic use*; D009767:Obesity, Morbid / Q000097:blood / Q000473:pathology*
chemical_list: D006442:Glycated Hemoglobin; D008687:Metformin; C517652:hemoglobin A1c protein, human
keywords: Abnormal liver enzymes; Mauriac syndrome; diabetes; hepatomegaly