title: Diagnosis of non-acute cerebral venous thrombosis with 3D T1-weighted black blood sequence at 3T.
abstract: BACKGROUND
  We investigated the value of 3D T1-weighted SPACE (Sampling Perfection with Application optimized Contrast using different angle Evolutions, a 3D fast spin echo black blood sequence) in the diagnosis of cerebral venous thrombosis (CVT).
  
  
  METHODS
  We prospectively included 31 consecutive patients who were suspected as having a CVT within one month of disease onset. The reference standard of CVT diagnosis was based on all of the conventional imaging tests (including susceptibility weighted imaging), clinical information, and prognosis information.
  
  
  RESULTS
  The final diagnosis of the CVT was made for 14 patients including 60 venous segments. The median time between disease onset and the examination with magnetic resonance was 12.5days with a range of 8 to 27days. The diagnosis results of susceptibility weighted imaging plus magnetic resonance venography (MRV) were consistent with the final diagnosis. The sensibility/specificity for T1 SPACE were 100%/100% per patient and 96.7%/100% per segment. The area under the curve based on patient for T1 SPACE was higher than that of standard magnetic resonance imaging (MRI) (1.0 vs. 0.80, P=0.02) and standard MRI plus MRV (1.0 vs. 0.91, P=0.14). The area under the curve based on segment for T1 SPACE was significant higher than that of standard MRI (0.98 vs. 0.81, P<0.001) and standard MRI plus MRV (0.98 vs. 0.87, P<0.001).
  
  
  CONCLUSIONS
  3D T1 SPACE offered excellent visualization of the thrombus as evident high signal intensity with an acceptable acquisition time. The use of 3D T1 SPACE may improve the accuracy of subacute CVT diagnosis.
authors.affiliation: Neuroscience Center, Stroke Center, Department of Neurology, The First Hospital of Jilin University, Xinmin Street 71#, Changchun 130021, China.
authors.forename: Peng-Peng
authors.initials: PP
authors.lastname: Niu
authors.affiliation: Neuroscience Center, Stroke Center, Department of Neurology, The First Hospital of Jilin University, Xinmin Street 71#, Changchun 130021, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Neuroscience Center, Stroke Center, Department of Neurology, The First Hospital of Jilin University, Xinmin Street 71#, Changchun 130021, China.
authors.forename: Zhen-Ni
authors.initials: ZN
authors.lastname: Guo
authors.affiliation: Neuroscience Center, Stroke Center, Department of Neurology, The First Hospital of Jilin University, Xinmin Street 71#, Changchun 130021, China.
authors.forename: Hang
authors.initials: H
authors.lastname: Jin
authors.affiliation: Department of Radiology, The First Hospital of Jilin University, Xinmin Street 71#, Changchun 130021, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Radiology, The First Hospital of Jilin University, Xinmin Street 71#, Changchun 130021, China. Electronic address: zhw7734@sohu.com.
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Zhou
authors.affiliation: Neuroscience Center, Stroke Center, Department of Neurology, The First Hospital of Jilin University, Xinmin Street 71#, Changchun 130021, China. Electronic address: doctoryangyi@163.com.
authors.forename: Yi
authors.initials: Y
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D019540:Area Under Curve; D001921:Brain / Q000000981:diagnostic imaging*; D002675:Child, Preschool; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020767:Intracranial Thrombosis / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010690:Phlebography / Q000379:methods; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D020246:Venous Thrombosis / Q000000981:diagnostic imaging*; D055815:Young Adult
keywords: Diagnosis; Magnetic resonance imaging; Sinus thrombosis, intracranial; Stroke; Venous thrombosis