title: Preventive Effects of Fermented Brown Rice and Rice Bran against Prostate Carcinogenesis in TRAP Rats.
abstract: Fermented brown rice and rice bran with Aspergillus oryzae (FBRA) is considered to have the potential to prevent chemically-induced carcinogenesis in multiple organs of rodents. In the present study, we evaluated the possible chemopreventive effects of FBRA against prostate tumorigenesis. Six-week-old male rats of the transgenic rat for adenocarcinoma of prostate (TRAP) strain were fed diets containing 5% or 10% FBRA for 15 weeks. Animals were sacrificed at 21 weeks of age, and the ventral and lateral prostate were removed for histopathological evaluation and immunoblot analyses. FBRA decreased the incidence of adenocarcinoma in the lateral prostate and suppressed the progression of prostate carcinogenesis. Treatment with FBRA induced apoptosis and inhibited cell proliferation in histologically high-grade prostatic intraepithelial neoplasias. Phospho-AMP-activated kinase α (Thr172) was up-regulated in the prostate of rats fed the diet supplemented with FBRA. These results indicate that FBRA controls tumor growth by activating pathways responsive to energy deprivation and suggest that FBRA has translational potential for the prevention of human prostate cancer.
authors.affiliation: Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1-Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan. tkuno@med.nagoya-cu.ac.jp.
authors.forename: Toshiya
authors.initials: T
authors.lastname: Kuno
authors.affiliation: Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1-Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan. me_me_sheep3@yahoo.co.jp.
authors.forename: Aya
authors.initials: A
authors.lastname: Nagano
authors.affiliation: Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1-Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan. ymori345@gmail.com.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Mori
authors.affiliation: Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1-Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan. h.kato@med.nagoya-cu.ac.jp.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kato
authors.affiliation: Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1-Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan. naga-p@dk.pdx.ne.jp.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Nagayasu
authors.affiliation: Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1-Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan. ayaito@med.nagoya-cu.ac.jp.
authors.forename: Aya
authors.initials: A
authors.lastname: Naiki-Ito
authors.affiliation: Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1-Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan. shugo@med.nagoya-cu.ac.jp.
authors.forename: Shugo
authors.initials: S
authors.lastname: Suzuki
authors.affiliation: A former president of Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan. hidmori@gifu-u-ac.jp.
authors.forename: Hideki
authors.initials: H
authors.lastname: Mori
authors.affiliation: Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1-Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan. sattak@med.nagoya-cu.ac.jp.
authors.forename: Satoru
authors.initials: S
authors.lastname: Takahashi
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism; D000230:Adenocarcinoma / Q000201:enzymology / Q000235:genetics / Q000473:pathology / Q000517:prevention & control*; D000821:Animal Feed; D000818:Animals; D000952:Antigens, Polyomavirus Transforming / Q000235:genetics; D017209:Apoptosis; D001236:Aspergillus oryzae / Q000502:physiology*; D049109:Cell Proliferation; D004043:Dietary Fiber / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004734:Energy Metabolism; D004789:Enzyme Activation; D005285:Fermentation; D006579:Heterozygote; D008297:Male; D012275:Oryza / Q000382:microbiology*; D010766:Phosphorylation; D011467:Prostate / Q000378:metabolism / Q000473:pathology; D019048:Prostatic Intraepithelial Neoplasia / Q000201:enzymology / Q000235:genetics / Q000473:pathology / Q000517:prevention & control*; D011471:Prostatic Neoplasms / Q000201:enzymology / Q000235:genetics / Q000473:pathology / Q000517:prevention & control*; D017207:Rats, Sprague-Dawley; D055647:Rats, Transgenic; D015398:Signal Transduction; D013997:Time Factors
chemical_list: D000952:Antigens, Polyomavirus Transforming; D004043:Dietary Fiber; D055372:AMP-Activated Protein Kinases
keywords: fermented brown rice and rice bran with Aspergillus oryzae (FBRA); prostate cancer; transgenic rat