title: Triterpenoids from the fruit of Schisandra glaucescens.
abstract: Five new triterpenoids, named schiglausins P-T (1-5), together with twelve known analogues (6-17), were isolated from the fruit of Schisandra glaucescens Diels. Their structures were determined by various spectroscopic methods, including HRESIMS, 1D and 2D NMR spectra and CD experiment. Additionally, all these compounds were tested for their cytotoxicities against B16 mouse melanoma cell line. Compounds 8, 11, 14, and 15 exhibited moderate anti-proliferative effects against B16 cells with IC50 values ranging from 3.64 to 27.00μM.
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Faculty of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China; Department of Pharmacy, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
authors.forename: Heng-Yi
authors.initials: HY
authors.lastname: Yu
authors.affiliation: Department of Pharmacy, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Faculty of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Faculty of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
authors.forename: Wen-Ming
authors.initials: WM
authors.lastname: Wu
authors.affiliation: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Faculty of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China. Electronic address: ruanhl@mails.tjmu.edu.cn.
authors.forename: Han-Li
authors.initials: HL
authors.lastname: Ruan
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification; D045744:Cell Line, Tumor / Q000187:drug effects; D005638:Fruit / Q000737:chemistry*; D008546:Melanoma, Experimental; D051379:Mice; D015394:Molecular Structure; D032141:Schisandra / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes
keywords: Cytotoxicity; Schisandra glaucescens Diels; Schisandraceae; Triterpenoids