title: Missing proof of cooperative synthesis of dopamine by non-dopaminergic neurons.
abstract: L-DOPA accumulation in the extracellular medium was detected when the transfer of L-DOPA from the neurons containing tyrosine hydroxylase to the neurons containing aromatic L-amino acid decarboxylase was blocked, under conditions of inhibition of the L-DOPA degradation enzyme. Thus, the missing proof confirming the existence of cooperative synthesis of dopamine by neurons non-dopaminergic was obtained.
authors.affiliation: Koltzov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow, 119991, Russia. kurina.anya@gmail.com.
authors.forename: A U
authors.initials: AU
authors.lastname: Kurina
authors.affiliation: Koltzov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow, 119991, Russia.
authors.forename: T S
authors.initials: TS
authors.lastname: Pronina
authors.affiliation: Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, ul. Baltiiskaya 8, Moscow, 125315, Russia.
authors.forename: V S
authors.initials: VS
authors.lastname: Kudrin
authors.affiliation: Koltzov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow, 119991, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Ugrumov
mesh_terms: D000818:Animals; D001142:Aromatic-L-Amino-Acid Decarboxylases / Q000378:metabolism; D001577:Benzophenones / Q000494:pharmacology; D065098:Catechol O-Methyltransferase Inhibitors / Q000494:pharmacology; D018920:Coculture Techniques; D004298:Dopamine / Q000096:biosynthesis*; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism; D007552:Isotonic Solutions / Q000737:chemistry; D007930:Leucine / Q000378:metabolism; D007980:Levodopa / Q000378:metabolism; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D009596:Nitrophenols / Q000494:pharmacology; D017208:Rats, Wistar; D013378:Substantia Nigra / Q000187:drug effects / Q000378:metabolism; D000077867:Tolcapone; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
chemical_list: D001577:Benzophenones; D065098:Catechol O-Methyltransferase Inhibitors; D007552:Isotonic Solutions; C051865:Krebs-Ringer solution; D009596:Nitrophenols; D007980:Levodopa; D000077867:Tolcapone; D014446:Tyrosine 3-Monooxygenase; D001142:Aromatic-L-Amino-Acid Decarboxylases; D007930:Leucine; D004298:Dopamine