title: Photoprotective Potential of Baccharis antioquensis (Asteraceae) as Natural Sunscreen.
abstract: In the quest for new natural agents of photoprotection, we evaluated the photoprotective and antioxidant activity of B. antioquensis leaf extracts as well as its phenolic composition. The methanolic extract treated with activated carbon showed the highest absorption coefficients for UVA-UVB radiation, as well as an antioxidant capacity comparable to butylated hydroxy toluene. Furthermore, the formulation containing this extract showed suitable sensorial and photostable characteristics for topical use, and significant values of UVAPF, critical wavelength (λc ), UVA/UVB ratio and sun protection factor (5.3, 378 nm, 0.78 and 9.1 ± 0.1, respectively). In addition, three glycoside derivatives of quercetin, a kaempferol glycoside and a derivative of caffeic acid were the main polyphenolic compounds identified. These results demonstrate the potential of B. antioquensis extracts to be used as active components of novel, natural sunscreens.
authors.affiliation: Research Group on Functional Compounds, Institute of Chemistry, University of Antioquia, Medellín, Colombia.
authors.forename: Juan C
authors.identifier: 0000-0003-4494-1446
authors.initials: JC
authors.lastname: Mejía-Giraldo
authors.affiliation: Department of Biotechnology and Biochemistry, CINVESTAV Unidad Irapuato, Irapuato, Mexico.
authors.forename: Robert
authors.initials: R
authors.lastname: Winkler
authors.affiliation: Group Stability of Drugs, Cosmetics and Food, Faculty of Pharmaceutical Chemistry, University of Antioquia, Medellín, Colombia.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Gallardo
authors.affiliation: Research Group on Functional Compounds, Institute of Chemistry, University of Antioquia, Medellín, Colombia.
authors.forename: Ana M
authors.initials: AM
authors.lastname: Sánchez-Zapata
authors.affiliation: Research Group on Functional Compounds, Institute of Chemistry, University of Antioquia, Medellín, Colombia. miguel.puertas@udea.edu.co.
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Puertas-Mejía
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D031175:Baccharis / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D006027:Glycosides / Q000737:chemistry / Q000494:pharmacology; D044949:Kaempferols / Q000737:chemistry / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D011794:Quercetin / Q000737:chemistry / Q000494:pharmacology; D059405:Sun Protection Factor; D013473:Sunscreening Agents / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D006027:Glycosides; D044949:Kaempferols; D010936:Plant Extracts; D013473:Sunscreening Agents; C006552:kaempferol; D011794:Quercetin