title: Lipid mediators as regulators of human ILC2 function in allergic diseases.
abstract: Group 2 innate lymphoid cells (ILC2) are specialized in type 2 immunity. ILC2 are activated early in immune responses and, despite their low abundance, are able to initiate and amplify allergic inflammation by orchestrating other type 2 immune cells. Based on recent discoveries, the spectrum of ILC2 regulating factors has been extended. It is now well established that not only epithelial cell-derived innate cytokines, but also bioactive lipids can regulate ILC2 activity and accumulation. Additionally, ILC2 appear to be susceptible to changes in the cytokine milieu and can acquire an ILC1-like phenotype due to a high degree of cellular plasticity. As ILC2 are fundamentally involved in the pathogenesis of type 2 diseases, they represent a promising therapeutic target for allergic airway and skin diseases. In this review we summarize the current knowledge about ILC2 biology in the allergy context, with a particular focus on the emerging role of lipid mediators in regulating ILC2 function.
authors.affiliation: Center for Infectious Medicine, Department of Medicine, Huddinge, Karolinska Institutet, 14186 Stockholm, Sweden; Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitaetsplatz 4, 8010 Graz, Austria.
authors.forename: Viktoria
authors.initials: V
authors.lastname: Konya
authors.affiliation: Center for Infectious Medicine, Department of Medicine, Huddinge, Karolinska Institutet, 14186 Stockholm, Sweden. Electronic address: jenny.mjosberg@ki.se.
authors.forename: Jenny
authors.initials: J
authors.lastname: Mjösberg
mesh_terms: D018927:Anti-Asthmatic Agents / Q000494:pharmacology / Q000627:therapeutic use; D000066670:Cell Plasticity / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy / Q000235:genetics / Q000276:immunology* / Q000378:metabolism*; D007113:Immunity, Innate / Q000187:drug effects; D018836:Inflammation Mediators / Q000378:metabolism*; D015289:Leukotrienes / Q000378:metabolism; D008055:Lipids; D044045:Lipoxins / Q000378:metabolism; D016131:Lymphocyte Subsets / Q000166:cytology / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism*; D058990:Molecular Targeted Therapy; D011453:Prostaglandins / Q000378:metabolism
chemical_list: D018927:Anti-Asthmatic Agents; D018836:Inflammation Mediators; D015289:Leukotrienes; D008055:Lipids; D044045:Lipoxins; D011453:Prostaglandins
keywords: Asthma; Atopic dermatitis; Innate lymphoid cells; Leukotrienes; Lipoxins; Prostaglandins