title: Multisite, multimodal neuroimaging of chronic urological pelvic pain: Methodology of the MAPP Research Network.
abstract: The Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network is an ongoing multi-center collaborative research group established to conduct integrated studies in participants with urologic chronic pelvic pain syndrome (UCPPS). The goal of these investigations is to provide new insights into the etiology, natural history, clinical, demographic and behavioral characteristics, search for new and evaluate candidate biomarkers, systematically test for contributions of infectious agents to symptoms, and conduct animal studies to understand underlying mechanisms for UCPPS. Study participants were enrolled in a one-year observational study and evaluated through a multisite, collaborative neuroimaging study to evaluate the association between UCPPS and brain structure and function. 3D T1-weighted structural images, resting-state fMRI, and high angular resolution diffusion MRI were acquired in five participating MAPP Network sites using 8 separate MRI hardware and software configurations. We describe the neuroimaging methods and procedures used to scan participants, the challenges encountered in obtaining data from multiple sites with different equipment/software, and our efforts to minimize site-to-site variation.
authors.affiliation: Department of Neurology, David Geffen School of Medicine at UCLA, USA; Department of Radiological Sciences, David Geffen School of Medicine at UCLA, USA; Department of Biomedical Physics, David Geffen School of Medicine at UCLA, USA; UCLA Brain Research Institute, David Geffen School of Medicine at UCLA, USA; UCLA Ahmanson-Lovelace Brain Mapping Center, David Geffen School of Medicine at UCLA, USA; NeuroSpectroScopics, LLC, Sherman Oaks, CA, USA.
authors.forename: Jeffry R
authors.initials: JR
authors.lastname: Alger
authors.affiliation: Department of Radiological Sciences, David Geffen School of Medicine at UCLA, USA; Department of Biomedical Physics, David Geffen School of Medicine at UCLA, USA; UCLA Brain Research Institute, David Geffen School of Medicine at UCLA, USA; Oppenheimer Center for Neurobiology of Stress at UCLA, David Geffen School of Medicine at UCLA, USA; Department of Bioengineering, Henry Samueli School of Engineering and Applied Science at UCLA, USA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, USA.
authors.forename: Benjamin M
authors.initials: BM
authors.lastname: Ellingson
authors.affiliation: Department of Internal Medicine, David Geffen School of Medicine at UCLA, USA; Oppenheimer Center for Neurobiology of Stress at UCLA, David Geffen School of Medicine at UCLA, USA.
authors.forename: Cody
authors.initials: C
authors.lastname: Ashe-McNalley
authors.affiliation: Department of Radiological Sciences, David Geffen School of Medicine at UCLA, USA; Department of Biomedical Physics, David Geffen School of Medicine at UCLA, USA; Oppenheimer Center for Neurobiology of Stress at UCLA, David Geffen School of Medicine at UCLA, USA.
authors.forename: Davis C
authors.initials: DC
authors.lastname: Woodworth
authors.affiliation: UCLA Brain Research Institute, David Geffen School of Medicine at UCLA, USA; Department of Internal Medicine, David Geffen School of Medicine at UCLA, USA; Oppenheimer Center for Neurobiology of Stress at UCLA, David Geffen School of Medicine at UCLA, USA.
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Labus
authors.affiliation: Department of Physiology, Feinberg School of Medicine, Northwestern University, 300 E. Superior St., Chicago, IL 60611, USA.
authors.forename: Melissa
authors.initials: M
authors.lastname: Farmer
authors.affiliation: Department of Physiology, Feinberg School of Medicine, Northwestern University, 300 E. Superior St., Chicago, IL 60611, USA.
authors.forename: Lejian
authors.initials: L
authors.lastname: Huang
authors.affiliation: Department of Physiology, Feinberg School of Medicine, Northwestern University, 300 E. Superior St., Chicago, IL 60611, USA; Departments of Anesthesia and Surgery, Feinberg School of Medicine, Northwestern University, 300 E. Superior St., Chicago, IL 60611, USA.
authors.forename: A Vania
authors.initials: AV
authors.lastname: Apkarian
authors.affiliation: Department of Neurology, Stanford University, Palo Alto, CA, USA.
authors.forename: Kevin A
authors.initials: KA
authors.lastname: Johnson
authors.affiliation: Department of Neurology, Stanford University, Palo Alto, CA, USA.
authors.forename: Sean C
authors.initials: SC
authors.lastname: Mackey
authors.affiliation: Department of Anesthesiology, University of Alabama, Birmingham, AL, USA.
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Ness
authors.affiliation: Department of Radiology, University of Alabama, Birmingham, AL, USA.
authors.forename: Georg
authors.initials: G
authors.lastname: Deutsch
authors.affiliation: Department of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.
authors.forename: Richard E
authors.initials: RE
authors.lastname: Harris
authors.affiliation: Department of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Clauw
authors.affiliation: Department of Radiology, Stanford University, Palo Alto, CA, USA.
authors.forename: Gary H
authors.initials: GH
authors.lastname: Glover
authors.affiliation: Department of Radiology, Northwestern University, Chicago, IL, USA.
authors.forename: Todd B
authors.initials: TB
authors.lastname: Parrish
authors.affiliation: Department of Radiology, University of Alabama at Birmingham, Birmingham, AL, USA.
authors.forename: Jan den
authors.initials: Jd
authors.lastname: Hollander
authors.affiliation: Division of Kidney, Urologic, and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
authors.forename: John W
authors.initials: JW
authors.lastname: Kusek
authors.affiliation: Division of Kidney, Urologic, and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Chris
authors.initials: C
authors.lastname: Mullins
authors.affiliation: UCLA Brain Research Institute, David Geffen School of Medicine at UCLA, USA; UCLA Ahmanson-Lovelace Brain Mapping Center, David Geffen School of Medicine at UCLA, USA; Department of Internal Medicine, David Geffen School of Medicine at UCLA, USA; Oppenheimer Center for Neurobiology of Stress at UCLA, David Geffen School of Medicine at UCLA, USA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, USA.
authors.forename: Emeran A
authors.initials: EA
authors.lastname: Mayer
mesh_terms: D000328:Adult; D035843:Biomedical Research / Q000458:organization & administration*; D001921:Brain / Q000000981:diagnostic imaging*; D059350:Chronic Pain; D015331:Cohort Studies; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D009434:Neural Pathways / Q000000981:diagnostic imaging*; D010100:Oxygen / Q000097:blood; D017699:Pelvic Pain / Q000000981:diagnostic imaging*; D012146:Rest; D055815:Young Adult
chemical_list: D010100:Oxygen
keywords: Brain; DTI; Diffusion tensor imaging; Functional magnetic resonance imaging; Magnetic resonance imaging; TransMAPP; Urologic chronic pelvic pain syndromes