title: Circulation of Tc Ia discrete type unit Trypanosoma cruzi in Yucatan Mexico.
abstract: The etiologic agent Trypanosoma cruzi (Tc) has been grouped into six discrete type units (DTU I-VI); within DTU-I exists four subgroups defined Ia-Id. In Colombia, the genotype Ia is associated with human infection and domiciliated Rhodnius vector. In the Yucatan Peninsula of Mexico, the main vector involved in T. cruzi transmission is Triatoma dimidiata predominantly via sylvatic and peridomiciliated cycles. In this study, multiple sequence analysis of mini-exon intergenic regions of T. cruzi isolates obtained from T. dimidiata in the Yucatan Peninsula of Mexico revealed they belonged to Tc Ia DTU along with two additional Mexican strains located 1,570 km away from Yucatan. In conclusion Tc Ia circulates in the Yucatan peninsula in T. dimidiata vector and likewise in the northwest region of Mexico.
authors.affiliation: Centro de Investigaciones Biomédicas, Universidad Autónoma de Campeche, Campus de la Salud, Col Linda Vista Campeche, 24090 Campeche, Mexico.
authors.forename: Victor
authors.initials: V
authors.lastname: Monteón
authors.affiliation: Grupo Biología y Control de Enfermedades Infecciosas (BCEI), Universidad de Antioquia, Medellín, Colombia.
authors.forename: Omar
authors.initials: O
authors.lastname: Triana-Chávez
authors.affiliation: Grupo Biología y Control de Enfermedades Infecciosas (BCEI), Universidad de Antioquia, Medellín, Colombia.
authors.forename: Ana
authors.initials: A
authors.lastname: Mejía-Jaramillo
authors.affiliation: Center for Health Studies, Universidad del Valle de Guatemala, Guatemala City, Guatemala.
authors.forename: Pamela
authors.initials: P
authors.lastname: Pennignton
authors.affiliation: Laboratorio de Investigación y Servicios (LADASIER) Inmunología y Biología Molecular, Universidad Veracruzana, Orizaba, Veracruz Mexico.
authors.forename: Ángel
authors.initials: Á
authors.lastname: Ramos-Ligonio
authors.affiliation: Centro Regional de Investigaciones Biomédicas "Hideyo Noguchi", Mérida, Yucatán Mexico.
authors.forename: Karla
authors.initials: K
authors.lastname: Acosta
authors.affiliation: Centro de Investigaciones Biomédicas, Universidad Autónoma de Campeche, Campus de la Salud, Col Linda Vista Campeche, 24090 Campeche, Mexico.
authors.forename: Ruth
authors.initials: R
authors.lastname: Lopez
keywords: Chagas disease; Discrete type unit; Spliced leader; Trypanosoma cruzi