title: A case-based reasoning view of thrombophilia risk.
abstract: Thrombophilia stands for a genetic or an acquired tendency to hypercoagulable states that increase the risk of venous and arterial thromboses. Indeed, venous thromboembolism is often a chronic illness, mainly in deep venous thrombosis and pulmonary embolism, requiring lifelong prevention strategies. Therefore, it is crucial to identify the cause of the disease, the most appropriate treatment, the length of treatment or prevent a thrombotic recurrence. Thus, this work will focus on the development of a diagnosis decision support system in terms of a formal agenda built on a logic programming approach to knowledge representation and reasoning, complemented with a case-based approach to computing. The proposed model has been quite accurate in the assessment of thrombophilia predisposition risk, since the overall accuracy is higher than 90% and sensitivity ranging in the interval [86.5%, 88.1%]. The main strength of the proposed solution is the ability to deal explicitly with incomplete, unknown, or even self-contradictory information.
authors.affiliation: Departamento de Química, Escola de Ciências e Tecnologia, Universidade de Évora, Évora, Portugal. Electronic address: jmvilhena@gmail.com.
authors.forename: João
authors.initials: J
authors.lastname: Vilhena
authors.affiliation: Departamento de Química, Escola de Ciências e Tecnologia, Universidade de Évora, Évora, Portugal; Centro Algoritmi, Universidade do Minho, Braga, Portugal. Electronic address: hvicente@uevora.pt.
authors.forename: Henrique
authors.initials: H
authors.lastname: Vicente
authors.affiliation: Departamento de Química, Escola de Ciências e Tecnologia, Laboratório HERCULES, Universidade de Évora, Évora, Portugal. Electronic address: mrm@uevora.pt.
authors.forename: M Rosário
authors.initials: MR
authors.lastname: Martins
authors.affiliation: Serviço de Patologia Clínica do Hospital do Espírito Santo de Évora EPE, Évora, Portugal. Electronic address: graneda1@sapo.pt.
authors.forename: José M
authors.initials: JM
authors.lastname: Grañeda
authors.affiliation: Serviço de Patologia Clínica do Hospital do Espírito Santo de Évora EPE, Évora, Portugal. Electronic address: filomenacaldeira1@gmail.com.
authors.forename: Filomena
authors.initials: F
authors.lastname: Caldeira
authors.affiliation: Serviço de Patologia Clínica do Hospital do Espírito Santo de Évora EPE, Évora, Portugal. Electronic address: gusmao.rodrigo@gmail.com.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Gusmão
authors.affiliation: Drs. Nicolas & Asp, Dubai, United Arab Emirates. Electronic address: joaocpneves@gmail.com.
authors.forename: João
authors.initials: J
authors.lastname: Neves
authors.affiliation: Centro Algoritmi, Universidade do Minho, Braga, Portugal. Electronic address: jneves@di.uminho.pt.
authors.forename: José
authors.initials: J
authors.lastname: Neves
mesh_terms: D003661:Decision Support Techniques; D006801:Humans; D011655:Pulmonary Embolism; D012008:Recurrence; D012307:Risk Factors; D019851:Thrombophilia / Q000453:epidemiology*; D020246:Venous Thrombosis
keywords: Case-based reasoning; Knowledge representation and reasoning; Logic programming; Similarity analysis; Thrombophilia; Venous thromboembolism