title: Primary Intraocular Diffuse Large B-cell Lymphoma: Diagnostic Difficulties in Deep Retinal Infiltrations with Vitritis.
abstract: OBJECTIVE
  Primary intraocular lymphoma (PIOL) is a rare malignancy with an aggressive clinical course. It is usually considered as a subset of primary central nervous system lymphoma. Differential diagnosis should include infectious and non-infectious aetiologies, particularly the common masqueraders sarcoidosis, tuberculosis, viral retinitis and syphilis.
  
  
  METHODS
  The article presents a case of bilateral vitreoretinal lymphoma manifesting as uveitis and vitritis resistant to corticosteroid therapy. The final diagnosis was based on a retinal biopsy.
  
  
  RESULTS
  The patient was successfully treated with systemic and local therapy. Long-term complete remission (CR) was reached. The relapse of diffuse large B-cell lymphoma was revealed in the frontal left lobe after 48 months of CR duration.
  
  
  CONCLUSIONS
  The diagnosis of PIOL is always very difficult. Cooperation of pathologists, ophthalmologists and hematologists is required for a quick and accurate diagnosis. Local and systemic treatment is needed to achieve CR, but the relapse rate remains very high.
authors.affiliation: Department and Clinic of Hematology, Blood Neoplastic Disorders and Bone Marrow Transplantation, Wroclaw Medical University, 4` Pasteur St, 50-367 Wroclaw, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Kapelko-Slowik
authors.affiliation: Department and Clinic of Hematology, Blood Neoplastic Disorders and Bone Marrow Transplantation, Wroclaw Medical University, 4` Pasteur St, 50-367 Wroclaw, Poland ; Wroclaw Physiotherapy College, Wroclaw, Poland.
authors.forename: Donata
authors.initials: D
authors.lastname: Urbaniak-Kujda
authors.affiliation: Department of Ophthalmology, Wroclaw Medical University, Wroclaw, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Turno-Krecicka
authors.affiliation: Department and Clinic of Hematology, Blood Neoplastic Disorders and Bone Marrow Transplantation, Wroclaw Medical University, 4` Pasteur St, 50-367 Wroclaw, Poland.
authors.forename: Stanislaw
authors.initials: S
authors.lastname: Potoczek
authors.affiliation: Department and Clinic of Hematology, Blood Neoplastic Disorders and Bone Marrow Transplantation, Wroclaw Medical University, 4` Pasteur St, 50-367 Wroclaw, Poland.
authors.forename: Jaroslaw
authors.initials: J
authors.lastname: Dybko
authors.affiliation: Department and Clinic of Hematology, Blood Neoplastic Disorders and Bone Marrow Transplantation, Wroclaw Medical University, 4` Pasteur St, 50-367 Wroclaw, Poland ; Department of Microbiology, Wroclaw Medical University, Wroclaw, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Biernat
authors.affiliation: Department of Ophthalmology, Wroclaw Medical University, Wroclaw, Poland.
authors.forename: Miroslaw
authors.initials: M
authors.lastname: Slowik
keywords: Chemotherapy; Lymphoma; Retinal infiltration; Uveitis; Vitritis