title: Parallel Profiles of Inflammatory and Effector Memory T Cells in Visceral Fat and Liver of Obesity-Associated Cancer Patients.
abstract: In the midst of a worsening obesity epidemic, the incidence of obesity-associated morbidities, including cancer, diabetes, cardiac and liver disease is increasing. Insights into mechanisms underlying pathological obesity-associated inflammation are lacking. Both the omentum, the principal component of visceral fat, and liver of obese individuals are sites of excessive inflammation, but to date the T cell profiles of both compartments have not been assessed or compared in a patient cohort with obesity-associated disease. We have previously identified that omentum is enriched with inflammatory cytokines, chemokines and T cells. Here, we compared the inflammatory profile of T cells in the omentum and liver of patients with the obesity-associated malignancy oesophageal adenocarcinoma (OAC). Furthermore, we assessed the secreted cytokine profile in OAC patient serum, omentum and liver to assess systemic and local inflammation. We observed parallel T cell cytokine profiles and phenotypes in the omentum and liver of OAC patients, in particular CD69(+) and inflammatory effector memory T cells. This study reflects similar processes of inflammation and T cell activation in the omentum and liver, and may suggest common targets to modulate pathological inflammation at these sites.
authors.affiliation: Department of Surgery, Trinity Translational Medicine Institute, Trinity College Dublin, St James's Hospital, Dublin 8, Ireland.
authors.forename: Melissa J
authors.initials: MJ
authors.lastname: Conroy
authors.affiliation: Department of Surgery, Trinity Translational Medicine Institute, Trinity College Dublin, St James's Hospital, Dublin 8, Ireland.
authors.forename: Karen C
authors.initials: KC
authors.lastname: Galvin
authors.affiliation: Department of Surgery, Trinity Translational Medicine Institute, Trinity College Dublin, St James's Hospital, Dublin 8, Ireland.|School of Biological Sciences, Dublin Institute of Technology, Dublin, Ireland.
authors.forename: Suzanne L
authors.initials: SL
authors.lastname: Doyle
authors.affiliation: Department of Surgery, Trinity Translational Medicine Institute, Trinity College Dublin, St James's Hospital, Dublin 8, Ireland.
authors.forename: Maria E
authors.initials: ME
authors.lastname: Kavanagh
authors.affiliation: Department of Surgery, Trinity Translational Medicine Institute, Trinity College Dublin, St James's Hospital, Dublin 8, Ireland.
authors.forename: Ann-Marie
authors.initials: AM
authors.lastname: Mongan
authors.affiliation: Department of Surgery, Trinity Translational Medicine Institute, Trinity College Dublin, St James's Hospital, Dublin 8, Ireland.
authors.forename: Aoife
authors.initials: A
authors.lastname: Cannon
authors.affiliation: Department of Surgery, Trinity Translational Medicine Institute, Trinity College Dublin, St James's Hospital, Dublin 8, Ireland.
authors.forename: Gillian Y
authors.initials: GY
authors.lastname: Moore
authors.affiliation: Department of Surgery, Trinity Translational Medicine Institute, Trinity College Dublin, St James's Hospital, Dublin 8, Ireland.|Oesophageal Unit, St. James's Hospital, Dublin, Ireland.
authors.forename: John V
authors.initials: JV
authors.lastname: Reynolds
authors.affiliation: Department of Surgery, Trinity Translational Medicine Institute, Trinity College Dublin, St James's Hospital, Dublin 8, Ireland. jlysaght@tcd.ie.
authors.forename: Joanne
authors.initials: J
authors.lastname: Lysaght
mesh_terms: D000230:Adenocarcinoma; D016207:Cytokines / Q000032:analysis; D004938:Esophageal Neoplasms; D006801:Humans; D007156:Immunologic Memory; D007249:Inflammation / Q000276:immunology / Q000473:pathology; D050152:Intra-Abdominal Fat / Q000276:immunology / Q000473:pathology*; D008099:Liver / Q000276:immunology / Q000473:pathology*; D009369:Neoplasms / Q000473:pathology*; D009765:Obesity / Q000150:complications / Q000473:pathology*; D009852:Omentum / Q000276:immunology / Q000473:pathology; D016176:T-Lymphocyte Subsets / Q000276:immunology*
chemical_list: D016207:Cytokines
keywords: T cells; cancer; inflammation; liver; obesity; omentum