title: The amide C-N bond of isatins as the directing group and the internal oxidant in Ru-catalyzed C-H activation and annulation reactions: access to 8-amido isocoumarins.
abstract: The N-O, N-N and O-O bonds are the frequently used internally oxidative directing groups used in various redox-neutral coupling reactions. The sole use of the C-N bond as the oxidizing directing group was reported recently by Li X. and co-workers for the Rh(iii)-catalyzed C-H activation of phenacyl ammonium salts. Herein, we report the use of the amide C-N bond of isatins as the oxidizing directing group for the Ru(ii)-catalyzed redox-neutral C-H activation and annulation reactions with alkynes which afford 8-amido isocoumarins. The reaction also features excellent regioselectivity with alkyl aryl substituted alkynes.
authors.affiliation: Chemical Science & Technology Division, CSIR-North East Institute of Science and Technology, AcSIR, Jorhat-785006, India. skgogoi1@gmail.com.
authors.forename: Partha Pratim
authors.initials: PP
authors.lastname: Kaishap
authors.affiliation: Department of Chemical Sciences, Tezpur University, Napaam, Tezpur-784028, India.
authors.forename: Bipul
authors.initials: B
authors.lastname: Sarma
authors.affiliation: Chemical Science & Technology Division, CSIR-North East Institute of Science and Technology, AcSIR, Jorhat-785006, India. skgogoi1@gmail.com.
authors.forename: Sanjib
authors.initials: S
authors.lastname: Gogoi