title: Optimization of desolvation process for fabrication of lactoferrin nanoparticles using quality by design approach.
abstract: The present work deals with the design and process optimization for preparation of lactoferrin nanoparticles as carrier for delivery of curcumin (CLf-NPs) using quality by design (QbD) approach. Desolvation technique was selected for preparation of Lf-NPs. The concept of QbD was followed in stepwise manner including risk analysis FMEA methodology. Plackett-Burman screening design employing eight factors and two levels was selected for screening study and custom design was selected for further analysis. Curcumin was used as model polyphenol for assessing the encapsulating efficiency of Lf-NPs.
authors.affiliation: a Post Graduate Department of Pharmaceutics , H. R. Patel Institute of Pharmaceutical Education and Research , Karwand Naka , Shirpur , Maharashtra , India.
authors.forename: Abhijeet P
authors.initials: AP
authors.lastname: Pandey
authors.affiliation: a Post Graduate Department of Pharmaceutics , H. R. Patel Institute of Pharmaceutical Education and Research , Karwand Naka , Shirpur , Maharashtra , India.
authors.forename: Mahesh P
authors.initials: MP
authors.lastname: More
authors.affiliation: a Post Graduate Department of Pharmaceutics , H. R. Patel Institute of Pharmaceutical Education and Research , Karwand Naka , Shirpur , Maharashtra , India.
authors.forename: Kiran P
authors.initials: KP
authors.lastname: Karande
authors.affiliation: a Post Graduate Department of Pharmaceutics , H. R. Patel Institute of Pharmaceutical Education and Research , Karwand Naka , Shirpur , Maharashtra , India.
authors.forename: Ramesh V
authors.initials: RV
authors.lastname: Chitalkar
authors.affiliation: a Post Graduate Department of Pharmaceutics , H. R. Patel Institute of Pharmaceutical Education and Research , Karwand Naka , Shirpur , Maharashtra , India.
authors.forename: Pravin O
authors.initials: PO
authors.lastname: Patil
authors.affiliation: a Post Graduate Department of Pharmaceutics , H. R. Patel Institute of Pharmaceutical Education and Research , Karwand Naka , Shirpur , Maharashtra , India.
authors.forename: Prashant K
authors.initials: PK
authors.lastname: Deshmukh
mesh_terms: D003474:Curcumin / Q000737:chemistry / Q000494:pharmacology; D016503:Drug Delivery Systems; D006367:HeLa Cells; D006801:Humans; D007781:Lactoferrin / Q000737:chemistry / Q000494:pharmacology; D053758:Nanoparticles / Q000737:chemistry*
chemical_list: D007781:Lactoferrin; D003474:Curcumin
keywords: Critical quality attributes; desolvation; lactoferrin; optimization; robustness