title: Context, Context, Context: New Gene Programs Linked to Bad Behavior in MLL-AF9-Initiated Leukemia.
abstract: In this issue of Cancer Cell, Stavropoulou et al. report that expression of the MLL-AF9 fusion results in acute myelogenous leukemia (AML) with different behaviors depending on cell context, which leads them to identify a transcriptional signature surprisingly resembling that of the epithelial-to-mesenchymal (EMT) transition, correlating with aggressiveness of disease.
authors.affiliation: Division of Hematology, Oncology and Bone Marrow Transplant, Department of Pediatrics, University of Colorado, Denver/Anschutz Medical Campus, 12800 East 19th Avenue, MS #8302, Aurora, CO 80045, USA.
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Watanabe
authors.affiliation: Division of Hematology, Oncology and Bone Marrow Transplant, Department of Pediatrics, University of Colorado, Denver/Anschutz Medical Campus, 12800 East 19th Avenue, MS #8302, Aurora, CO 80045, USA. Electronic address: patricia.ernst@ucdenver.edu.
authors.forename: Patricia
authors.initials: P
authors.lastname: Ernst
mesh_terms: D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics*; D015514:Oncogene Proteins, Fusion / Q000235:genetics*
chemical_list: D015514:Oncogene Proteins, Fusion; D051788:Myeloid-Lymphoid Leukemia Protein