title: Access to C4-Functionalized Quinolines via Copper-Catalyzed Tandem Annulation of Alkynyl Imines with Diazo Compounds.
abstract: An efficient synthesis of C4-functionalized quinolines through copper-catalyzed tandem annulation of alkynyl imines with diazo compounds is described. This transformation involves an in situ formation of allene and intramolecular electrocyclization, which features high efficiency, mild reaction conditions, easy operation, and broad functional-group tolerance. A wide variety of C4-functionalized quinolines were provided in up to 92% yield for 33 examples.
authors.affiliation: Key Laboratory of Xiamen Marine and Gene Drugs, Institutes of Molecular Medicine and School of Biomedical Sciences, Huaqiao University and Engineering Research Center of Molecular Medicine, Ministry of Education , Xiamen 361021, China.
authors.forename: Ruifeng
authors.initials: R
authors.lastname: Zhu
authors.affiliation: Key Laboratory of Xiamen Marine and Gene Drugs, Institutes of Molecular Medicine and School of Biomedical Sciences, Huaqiao University and Engineering Research Center of Molecular Medicine, Ministry of Education , Xiamen 361021, China.
authors.forename: Guolin
authors.initials: G
authors.lastname: Cheng
authors.affiliation: Key Laboratory of Xiamen Marine and Gene Drugs, Institutes of Molecular Medicine and School of Biomedical Sciences, Huaqiao University and Engineering Research Center of Molecular Medicine, Ministry of Education , Xiamen 361021, China.
authors.forename: Chunqi
authors.initials: C
authors.lastname: Jia
authors.affiliation: Key Laboratory of Xiamen Marine and Gene Drugs, Institutes of Molecular Medicine and School of Biomedical Sciences, Huaqiao University and Engineering Research Center of Molecular Medicine, Ministry of Education , Xiamen 361021, China.
authors.forename: Lulu
authors.initials: L
authors.lastname: Xue
authors.affiliation: Key Laboratory of Xiamen Marine and Gene Drugs, Institutes of Molecular Medicine and School of Biomedical Sciences, Huaqiao University and Engineering Research Center of Molecular Medicine, Ministry of Education , Xiamen 361021, China.
authors.forename: Xiuling
authors.initials: X
authors.lastname: Cui