title: A case of first-onset psychosis and repeated relapses secondary to discontinuation of non-prescription estrogen replacement therapy in a transgendered female.
abstract: The estrogen hypothesis of psychosis states that estrogens contribute a protective effect against the development of psychotic disorders. Conversely, hypoestrogenic states have been shown to be associated with the occurrence of psychotic disorders in women. We present the case of a 24-year-old transgendered female who experienced a first-onset psychosis and subsequent relapses associated with discontinuation of non-prescription estrogen replacement therapy.
authors.affiliation: a Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston , Houston , TX , USA.
authors.forename: Olivia
authors.initials: O
authors.lastname: Moffitt
authors.affiliation: a Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston , Houston , TX , USA.
authors.forename: Jonathan Chase
authors.initials: JC
authors.lastname: Findley
mesh_terms: D000328:Adult; D015914:Estrogen Replacement Therapy / Q000009:adverse effects*; D005260:Female; D006801:Humans; D011618:Psychotic Disorders / Q000209:etiology*; D063106:Transgender Persons; D055815:Young Adult; D008297:Male
keywords: Central nervous system; depression; estrogen; hormone replacement therapy; psychosis; transgender