title: A multistep continuous flow synthesis machine for the preparation of pyrazolesviaa metal-free amine-redox process.
abstract: A versatile multistep continuous flow setup is reported for the four-step conversion of anilines into pyrazole products. The synthesis machine incorporates the use of amine-redox chemistry through diazotization and a metal-free vitamin C mediated reduction. The machine can be used for the synthesis of an array of analogues or the scale up of an individual target.
authors.affiliation: Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge , CB2 1EW , UK.
authors.forename: Jian-Siang
authors.initials: JS
authors.lastname: Poh
authors.affiliation: Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge , CB2 1EW , UK ; School of Chemistry , Cardiff University , Main Building, Park Place , CF10 3AT , UK . Email: dlbrowne@cardiff.ac.uk.
authors.forename: Duncan L
authors.initials: DL
authors.lastname: Browne
authors.affiliation: Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge , CB2 1EW , UK.
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley