title: Palladium-Catalyzed 6-Endo Selective Alkyl-Heck Reactions: Access to 5-Phenyl-1,2,3,6-tetrahydropyridine Derivatives.
abstract: A new type of palladium-catalyzed 6-endo-selective alkyl-Heck reaction of unactivated alkyl iodides has been described. This strategy provides efficient access to a variety of 5-phenyl-1,2,3,6-tetrahydropyridine derivatives, which are important structural motifs for bioactive molecules. This process displays a broad substrate scope with excellent 6-endo selectivity. Mechanistic investigations reveal that this alkyl-Heck reaction performs via a hybrid palladium-radical process.
authors.affiliation: School of Chemical Engineering, Shandong University of Technology , 266 West Xincun Road, Zibo 255049, P. R. China.
authors.forename: Xu
authors.initials: X
authors.lastname: Dong
authors.affiliation: School of Chemical Engineering, Shandong University of Technology , 266 West Xincun Road, Zibo 255049, P. R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Han
authors.affiliation: School of Chemical Engineering, Shandong University of Technology , 266 West Xincun Road, Zibo 255049, P. R. China.
authors.forename: Fachao
authors.initials: F
authors.lastname: Yan
authors.affiliation: School of Chemical Engineering, Shandong University of Technology , 266 West Xincun Road, Zibo 255049, P. R. China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Liu
authors.affiliation: School of Chemical Engineering, Shandong University of Technology , 266 West Xincun Road, Zibo 255049, P. R. China.
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.affiliation: School of Chemical Engineering, Shandong University of Technology , 266 West Xincun Road, Zibo 255049, P. R. China.
authors.forename: Kexun
authors.initials: K
authors.lastname: Chen
authors.affiliation: School of Chemical Engineering, Shandong University of Technology , 266 West Xincun Road, Zibo 255049, P. R. China.
authors.forename: Yueyun
authors.initials: Y
authors.lastname: Li
authors.affiliation: School of Chemical Engineering, Shandong University of Technology , 266 West Xincun Road, Zibo 255049, P. R. China.
authors.forename: Zengdian
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: School of Chemical Engineering, Shandong University of Technology , 266 West Xincun Road, Zibo 255049, P. R. China.
authors.forename: Yunhui
authors.initials: Y
authors.lastname: Dong
authors.affiliation: School of Chemical Engineering, Shandong University of Technology , 266 West Xincun Road, Zibo 255049, P. R. China.|College of Materials Science and Engineering, Hunan University , Changsha, Hunan 410082, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Liu