title: Role of Stereotactic Body Radiation Therapy with Volumetric-Modulated Arcs and High-Intensity Photon Beams for the Treatment of Abdomino-Pelvic Lymph-Node Metastases.
abstract: OBJECTIVE
  To study clinical outcome for oligometastatic patients (abdominal lymph-node metastases) treated with stereotactic body radiation therapy.
  
  
  METHODS
  Seventy-one patients were studied retrospectively. Dose prescription was 45 Gy in six fractions. Clinical outcome was assessed with actuarial analysis.
  
  
  RESULTS
  The median follow-up was 1.5 years; 45 patients (63.3%) had solitary metastasis, and 26 (36.6%) had multiple lesions. Local control was achieved in 97.5% with a 1-year actuarial rate of 83%. Two-year progression-free survival was 63.1%, and the overall survival was 76.9%. Two patients (3%) developed grade 2 gastro-enteric toxicity.
  
  
  CONCLUSIONS
  The treatment provided adequate clinical response in the management of oligometastatic cases.
authors.affiliation: a Radiotherapy and Radiosurgery Department , Humanitas Cancer Center and Research Hospital , Milan , Italy.
authors.forename: Ciro
authors.initials: C
authors.lastname: Franzese
authors.affiliation: a Radiotherapy and Radiosurgery Department , Humanitas Cancer Center and Research Hospital , Milan , Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Cozzi
authors.affiliation: a Radiotherapy and Radiosurgery Department , Humanitas Cancer Center and Research Hospital , Milan , Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Franceschini
authors.affiliation: a Radiotherapy and Radiosurgery Department , Humanitas Cancer Center and Research Hospital , Milan , Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: D'Agostino
authors.affiliation: a Radiotherapy and Radiosurgery Department , Humanitas Cancer Center and Research Hospital , Milan , Italy.
authors.forename: Tiziana
authors.initials: T
authors.lastname: Comito
authors.affiliation: a Radiotherapy and Radiosurgery Department , Humanitas Cancer Center and Research Hospital , Milan , Italy.
authors.forename: Fiorenza
authors.initials: F
authors.lastname: De Rose
authors.affiliation: a Radiotherapy and Radiosurgery Department , Humanitas Cancer Center and Research Hospital , Milan , Italy.
authors.forename: Pierina
authors.initials: P
authors.lastname: Navarria
authors.affiliation: a Radiotherapy and Radiosurgery Department , Humanitas Cancer Center and Research Hospital , Milan , Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Mancosu
authors.affiliation: a Radiotherapy and Radiosurgery Department , Humanitas Cancer Center and Research Hospital , Milan , Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Tomatis
authors.affiliation: a Radiotherapy and Radiosurgery Department , Humanitas Cancer Center and Research Hospital , Milan , Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Fogliata
authors.affiliation: a Radiotherapy and Radiosurgery Department , Humanitas Cancer Center and Research Hospital , Milan , Italy.
authors.forename: Marta
authors.initials: M
authors.lastname: Scorsetti
mesh_terms: D000008:Abdominal Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000532:radiotherapy* / Q000556:secondary*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D010386:Pelvic Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000532:radiotherapy* / Q000556:secondary*; D017785:Photons; D049268:Positron-Emission Tomography; D011874:Radiometry; D016634:Radiosurgery / Q000009:adverse effects / Q000379:methods; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects / Q000379:methods; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
keywords: Abdominal metastases; RapidArc; flattening filter-free beams; volumetric-modulated arc therapy