title: DOCK8 deficiency in six Iranian patients.
abstract: DOCK8 deficiency is a rare autosomal recessive combined immunodeficiency with high IgE level, eosinophilia, severe eczema, extensive cutaneous viral, and respiratory bacterial infections, mostly in populations with higher prevalence of consanguinity. Molecular diagnosis of this gene is a useful approach for early diagnosis and timely HSCT due to deleterious consequences.
authors.affiliation: Immunology Asthma and Allergy Research Institute Tehran University of Medical Sciences Tehran Iran.
authors.forename: Shiva
authors.initials: S
authors.lastname: Saghafi
authors.affiliation: Immunology Asthma and Allergy Research Institute Tehran University of Medical Sciences Tehran Iran; Departments of Immunology and Allergy Children Medical Center Tehran University of Medical Sciences Tehran Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Pourpak
authors.affiliation: Centre for Chronic Immunodeficiency (CCI) University Medical Center Freiburg and University of Freiburg Freiburg Germany.
authors.forename: Franziska
authors.initials: F
authors.lastname: Nussbaumer
authors.affiliation: Immunology Asthma and Allergy Research Institute Tehran University of Medical Sciences Tehran Iran.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Fazlollahi
authors.affiliation: Department of Medical Genetics National Institute for Genetic Engineering and Biotechnology Tehran Iran.
authors.forename: Massoud
authors.initials: M
authors.lastname: Houshmand
authors.affiliation: Hematology-Oncology and Stem Cell Transplantation Research Center Tehran University of Medical Sciences Tehran Iran.
authors.forename: Amir Ali
authors.initials: AA
authors.lastname: Hamidieh
authors.affiliation: Department of Allergy and Clinical Immunology Rasoul-e-Akram Hospital Iran University of Medical Sciences Tehran Iran.
authors.forename: Mohammad Hassan
authors.initials: MH
authors.lastname: Bemanian
authors.affiliation: Department of Allergy and Clinical Immunology Rasoul-e-Akram Hospital Iran University of Medical Sciences Tehran Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Nabavi
authors.affiliation: Departments of Immunology and Allergy Children Medical Center Tehran University of Medical Sciences Tehran Iran.
authors.forename: Nima
authors.initials: N
authors.lastname: Parvaneh
authors.affiliation: Centre for Chronic Immunodeficiency (CCI) University Medical Center Freiburg and University of Freiburg Freiburg Germany.
authors.forename: Bodo
authors.initials: B
authors.lastname: Grimbacher
authors.affiliation: Immunology Asthma and Allergy Research Institute Tehran University of Medical Sciences Tehran Iran; Departments of Immunology and Allergy Children Medical Center Tehran University of Medical Sciences Tehran Iran.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Moin
authors.affiliation: Centre for Chronic Immunodeficiency (CCI) University Medical Center Freiburg and University of Freiburg Freiburg Germany.
authors.forename: Cristina
authors.initials: C
authors.lastname: Glocker
keywords: Allergy; DOCK8; autosomal recessive; hyper IgE syndrome