title: Frontal cortex reactivity differentiates between schizophrenic subtypes: auditory ERP-evidence.
abstract: OBJECTIVE
  To extend the hypothesis that late auditory EP shifts represent pathophysiologcial markers in schizophrenia.
  
  
  METHODS
  Early negative (±100 μs) and late positive (>300 ms) auditory oddball and CNV responses are topographically compared in 3 medicated schizophrenic subtypes.
  
  
  RESULTS
  Only late cortical responses differentiate between paranoid, residual and disorganised schizophrenia. Core features of the deficit residual state encompass low-voltage N2P3 responses and missing central initial CNV components. Both paranoid and disorganised schizophrenics show a distinctive reactivity of the frontal cortex. Paranoid schizophrenia is characterized by an extensive frontal spread of the task-related P3 response. Disorganised schizophrenia shows a specifically increased frontal CNV component indicating a nonspecific arousal reaction.
  
  
  CONCLUSIONS
  Combinations of late auditory EP-patterns fairly fit with the cognitive/behavioral status observed in schizophrenia spectrum disorders.
authors.affiliation: 1Dept. Clin. Neurophysiol,Medical Centre St-Jozef Bilzen,Belgium.
authors.forename: B V
authors.initials: BV
authors.lastname: Sweden
authors.affiliation: 1Dept. Clin. Neurophysiol,Medical Centre St-Jozef Bilzen,Belgium.
authors.forename: M G
authors.initials: MG
authors.lastname: Erp
authors.affiliation: 2Psychiatry,Medical Centre St-Jozef Bilzen,Belgium.
authors.forename: F
authors.initials: F
authors.lastname: Mesotten
authors.affiliation: Dept. Psychiatry and Neuropsychology,Maastricht University,The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Maes
keywords: N1P2/N2P3; PINV responses; auditory oddball; iCNV/tCNV; schizophrenic subtypes; specificity; topography