title: Minimally invasive curved-micro-drainer (CMD) capable of innocuous drainage of subretinal fluid for the treatment of retinal detachment.
abstract: Retinal detachment is a serious vision threatening disease. Current consensus for the treatment of retinal detachment is to reattach the retina onto the choroid layer by drainage of accumulated subretinal fluid. Although several surgical methods have been developed, no satisfactory visual outcome has been obtained without surgical complications such as unintended puncture and hemorrhage of the retina and choroid tissue. In this study, we developed a novel Curved-Micro-Drainer (CMD) for the innocuous drainage of subretinal fluid. It is a curved structure with a 15° beveled tip that is 5 mm in length, with an 80 μm inner diameter and a 100 μm outer diameter. This high inner-to-outer diameter ratio of CMD with a 100 μm outer diameter allows efficient drainage of highly viscous subretinal fluid in a minimally invasive manner. In addition, the curved structure precisely matches the spherical ocular structure, which facilitates the CMD insertion into the subretinal space without choroid tissue damage. We demonstrate that the optimized CMD allows for the innocuous drainage of the viscous subretinal fluid from the porcine eye, whereas the traditional hypodermic needle (31-gauge) induces severe retinal and choroid damage. CMD can overcome a critical safety issue and is a potential alternative to conventional surgical interventions for the innocuous drainage of subretinal fluid.
authors.affiliation: Department of Biotechnology, Yonsei University, 50 Yonsei-ro, Seodeamun-gu, Seoul, 03722, Republic of Korea.
authors.forename: Yonghao
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Department of Biotechnology, Yonsei University, 50 Yonsei-ro, Seodeamun-gu, Seoul, 03722, Republic of Korea.
authors.forename: ChangYeol
authors.initials: C
authors.lastname: Lee
authors.affiliation: Department of Biotechnology, Yonsei University, 50 Yonsei-ro, Seodeamun-gu, Seoul, 03722, Republic of Korea.
authors.forename: Cheng Guo
authors.initials: CG
authors.lastname: Li
authors.affiliation: Nune Eye Hospital, B1 Noon Bldg, 907-16 Daechi-dong Gangnam-gu, Seoul, 135-280, Republic of Korea.
authors.forename: Yong Sung
authors.initials: YS
authors.lastname: You
authors.affiliation: Lumieye Genetics Co. Ltd., B1 Noon Bldg, 907-16 Daechi-dong Gangnam-gu, Seoul, 135-280, Republic of Korea.
authors.forename: Ho Lee
authors.initials: HL
authors.lastname: Sung
authors.affiliation: Department of Biotechnology, Yonsei University, 50 Yonsei-ro, Seodeamun-gu, Seoul, 03722, Republic of Korea. hijung@yonsei.ac.kr.
authors.forename: Hyungil
authors.identifier: 0000-0002-1946-7300
authors.initials: H
authors.lastname: Jung
mesh_terms: D000328:Adult; D000818:Animals; D002829:Choroid / Q000378:metabolism; D004322:Drainage / Q000295:instrumentation*; D005240:Feasibility Studies; D006801:Humans; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D009339:Needles; D012160:Retina / Q000378:metabolism; D012163:Retinal Detachment / Q000628:therapy*; D058471:Subretinal Fluid / Q000737:chemistry*; D013552:Swine
keywords: Hollow microneedle; Retinal detachment; Subretinal fluid; Vitrectomy