title: Synthesis of asymmetric zinc(II) phthalocyanines with two different functional groups & spectroscopic properties and photodynamic activity for photodynamic therapy.
abstract: Zinc(II) phthalocyanine containing [2-(tert-butoxycarbonyl)amino]ethoxy and iodine groups (A and B), as well as their deprotected mono-amino and tri-iodine zinc(II) phthalocyanine (2) were obtained. This structure surrounds by substituents with functional groups. From this perspective it can be used a starting material for many reactions and applications, such as sonogashira coupling, carbodiimide coupling. An example of a first diversification reaction of this compound was obtained with conjugation of a biotin. Asymmetrically biotin conjugated and heavy atom bearing zinc(II) phthalocyanine (3) were synthesized characterized for the first time and photophysical, photochemical and photobiological properties of these phthalocyanines were compared in this study.
authors.affiliation: Kocaeli University, Kosekoy Vocational School, PO Box 141, Kartepe, Kocaeli 41135, Turkey. Electronic address: meltemgoksel@gmail.com.
authors.forename: Meltem
authors.initials: M
authors.lastname: Göksel
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000528:radiation effects; D001710:Biotin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry* / Q000528:radiation effects; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000528:radiation effects; D004355:Drug Stability; D006367:HeLa Cells; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000528:radiation effects; D010778:Photochemotherapy; D010782:Photolysis; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000528:radiation effects; D011789:Quantum Theory; D012995:Solubility; D014466:Ultraviolet Rays; D015032:Zinc / Q000737:chemistry* / Q000528:radiation effects
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D007211:Indoles; D017319:Photosensitizing Agents; D001710:Biotin; D015032:Zinc
keywords: Biotin; Coupling; Functional groups; Photodynamic therapy; Zinc(II) phthalocyanine