title: Validation of a substance and alcohol use assessment instrument among orphans and vulnerable children in Zambia using Audio Computer Assisted Self-Interviewing (ACASI).
abstract: Substance and alcohol misuse is a global problem that increases the risk of HIV infection. This is a concern among orphans and vulnerable children (OVC) in sub-Saharan Africa who may have elevated substance use rates. The Alcohol, Smoking, and Substance Involvement Screening Test (ASSIST) is a reliable and valid instrument of substance use among adults in primary care high-income settings. This study examined psychometric properties of the ASSIST among OVC in Zambia using Audio Computer Assisted Self-Interviewing (ACASI).
  
  
  
  Baseline data from an ongoing randomized trial of interventions to reduce HIV risk behaviors were analyzed. The analysis included 502 OVC ages 13-17 living in low-income, high-density neighborhoods in Lusaka, Zambia. Internal consistency of the ASSIST was assessed and discriminant validity was measured using items from the Youth Self Report as criterion variables.
  
  
  
  Internal reliability was strong with a Cronbach's alpha of ≥0.80 for each of the specific substance scales and total substance involvement. For all substances except tobacco and sedatives, discriminant validity was demonstrated in distinguishing between low risk use and moderate use. Sensitivity and specificity analysis indicated adequate area under the curve across substance types (AUC range: 0.68-0.80). Discrimination between moderate and high risk was demonstrated for alcohol and total substance involvement.
  
  
  
  ASSIST administered via ACASI is a reliable instrument and an appropriate tool for distinguishing between low and hazardous substance use among adolescent OVC populations in sub-Saharan Africa. Additional examination is warranted to determine its ability to measure gradations of severity within hazardous use.
authors.affiliation: Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, 624 North Broadway, Baltimore, MD 21205, United States.
authors.forename: Jeremy C
authors.initials: JC
authors.lastname: Kane
authors.affiliation: Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, 624 North Broadway, Baltimore, MD 21205, United States.
authors.forename: Laura K
authors.initials: LK
authors.lastname: Murray
authors.affiliation: Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, 624 North Broadway, Baltimore, MD 21205, United States.
authors.forename: Judith K
authors.initials: JK
authors.lastname: Bass
authors.affiliation: Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, 624 North Broadway, Baltimore, MD 21205, United States.
authors.forename: Renee M
authors.initials: RM
authors.lastname: Johnson
authors.affiliation: Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, 624 North Broadway, Baltimore, MD 21205, United States; Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, United States. Electronic address: jkane29@jhu.edu.
authors.forename: Paul
authors.initials: P
authors.lastname: Bolton
mesh_terms: D000293:Adolescent; D000428:Alcohol Drinking / Q000191:economics / Q000453:epidemiology*; D054540:Child, Orphaned; D003146:Communications Media / Q000191:economics / Q000592:standards; D003936:Diagnosis, Computer-Assisted / Q000191:economics / Q000379:methods / Q000592:standards*; D005260:Female; D006801:Humans; D008297:Male; D015203:Reproducibility of Results; D057566:Self Report / Q000191:economics / Q000592:standards*; D012907:Smoking / Q000191:economics / Q000453:epidemiology; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000191:economics / Q000453:epidemiology*; D011795:Surveys and Questionnaires; D035862:Vulnerable Populations; D015024:Zambia / Q000453:epidemiology
keywords: ASSIST; Adolescent; HIV; Orphans and vulnerable children; Psychometrics; Substance use; Youth Self Report; sub-Saharan Africa