title: Oxidative Stress Related Diseases in Newborns.
abstract: We review oxidative stress-related newborn disease and the mechanism of oxidative damage. In addition, we outline diagnostic and therapeutic strategies and future directions. Many reports have defined oxidative stress as an imbalance between an enhanced reactive oxygen/nitrogen species and the lack of protective ability of antioxidants. From that point of view, free radical-induced damage caused by oxidative stress seems to be a probable contributing factor to the pathogenesis of many newborn diseases, such as respiratory distress syndrome, bronchopulmonary dysplasia, periventricular leukomalacia, necrotizing enterocolitis, patent ductus arteriosus, and retinopathy of prematurity. We share the hope that the new understanding of the concept of oxidative stress and its relation to newborn diseases that has been made possible by new diagnostic techniques will throw light on the treatment of those diseases.
authors.affiliation: Department of Pediatric Infectious Diseases, Hacettepe University, Faculty of Medicine, 06100 Ankara, Turkey.
authors.forename: Yasemin
authors.identifier: 0000-0001-8662-6909
authors.initials: Y
authors.lastname: Ozsurekci
authors.affiliation: Department of Pediatric Infectious Diseases, Hacettepe University, Faculty of Medicine, 06100 Ankara, Turkey.
authors.forename: Kubra
authors.initials: K
authors.lastname: Aykac
mesh_terms: D000975:Antioxidants; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000209:etiology*; D008297:Male; D018384:Oxidative Stress / Q000502:physiology*; D012127:Respiratory Distress Syndrome, Newborn / Q000209:etiology*
chemical_list: D000975:Antioxidants