title: The First Cut Is the Deepest: The History and Development of Safe Treatments for Wound Healing and Tissue Repair.
abstract: As the skin is the primary barrier to infection, the importance of wound healing has been understood since ancient times. This article provides a synopsis on the symposium presentations focusing on how wounds were traditionally treated, what models and pathology endpoints exist to study wound healing, special considerations for wound healing studies, an overview of regulatory aspects of new pharmaceutical and medical device development, and the clinical relevance of such models. The clinical treatment of small and large wounds is also considered.
authors.affiliation: LoneStar PharmTox LLC, Bergheim, TX, USA.
authors.forename: David W
authors.initials: DW
authors.lastname: Hobson
authors.affiliation: JCL Schuh, PLLC, Bainbridge Island, WA, USA.
authors.forename: JoAnn C L
authors.initials: JC
authors.lastname: Schuh
authors.affiliation: Wound Infections Department, Bacterial Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
authors.forename: Daniel V
authors.initials: DV
authors.lastname: Zurawski
authors.affiliation: Division of Dermatology and Dental Products (DDDP), OND/CDER/FDA, Silver Spring, MD, USA.
authors.forename: Jianyong
authors.initials: J
authors.lastname: Wang
authors.affiliation: University of Washington, Seattle, WA, USA.
authors.forename: Sam
authors.initials: S
authors.lastname: Arbabi
authors.affiliation: PreClinical Research Services, Inc, Fort Collins, CO, USA.
authors.forename: Maralee
authors.initials: M
authors.lastname: McVean
authors.affiliation: Experimental Pathology Laboratories, Inc, Sterling, VA, USA kfunk@epl-inc.com.
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: Funk
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use; D003226:Congresses as Topic; D004195:Disease Models, Animal; D006801:Humans; D012867:Skin / Q000187:drug effects / Q000382:microbiology / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects*; D014946:Wound Infection / Q000188:drug therapy / Q000382:microbiology; D014947:Wounds and Injuries / Q000188:drug therapy / Q000382:microbiology
chemical_list: D000890:Anti-Infective Agents
keywords: skin injury; tissue repair; wound healing