title: Influence of Medication on Fatigue Six Months after Stroke.
abstract: Poststroke fatigue (PSF) is frequent and affects patients' quality of life. Medication use was hypothesized as being responsible for PSF. Our objective was to evaluate potential relationships between 6-month PSF and medication use at discharge and 6 months after an ischemic stroke. This study is part of STROKDEM, an ongoing longitudinal cohort study, whose main aim is to determine predictors of poststroke dementia. Patients were included within 72 hours after an ischemic stroke and followed up with standardized evaluations. Medication use 7 days and 6 months after stroke was rated, and polypharmacy was defined as the number of categories of treatments received by a patient. PSF was evaluated using the Chalder Fatigue Scale. Medical history, vascular risk factors, depression, anxiety, and sleep disturbances were evaluated. One hundred and fifty-three patients were included: 52.9% presented PSF. PSF at 6 months was not predicted by medication use at discharge nor associated with medication use at month 6. We found severity of PSF to be increased in patients with polypharmacy. Our results suggest that PSF is not a side effect of drugs use, which more reflects presence of disturbances frequently observed after stroke such as depression, anxiety, or sleep disturbances. Clinical study is registered on clinicaltrials.gov (NCT01330160).
authors.affiliation: Degenerative & Vascular Cognitive Disorders, Univ. Lille, INSERM U1171, 59000 Lille, France; Department of Medical Pharmacology, Univ. Lille, 59000 Lille, France; Department of Neurology, Lille University Hospital, 59000 Lille, France.
authors.forename: Amélie
authors.identifier: 0000-0001-5324-6600
authors.initials: A
authors.lastname: Ponchel
authors.affiliation: Department of Statistics, EA 2694, Univ. Lille, 59000 Lille, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Labreuche
authors.affiliation: Degenerative & Vascular Cognitive Disorders, Univ. Lille, INSERM U1171, 59000 Lille, France; Department of Neurology, Lille University Hospital, 59000 Lille, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Bombois
authors.affiliation: Degenerative & Vascular Cognitive Disorders, Univ. Lille, INSERM U1171, 59000 Lille, France; Department of Neuroradiology, Lille University Hospital, 59000 Lille, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Delmaire
authors.affiliation: Degenerative & Vascular Cognitive Disorders, Univ. Lille, INSERM U1171, 59000 Lille, France; Department of Medical Pharmacology, Univ. Lille, 59000 Lille, France.
authors.forename: Régis
authors.initials: R
authors.lastname: Bordet
authors.affiliation: Degenerative & Vascular Cognitive Disorders, Univ. Lille, INSERM U1171, 59000 Lille, France; Department of Neurology, Lille University Hospital, 59000 Lille, France.
authors.forename: Hilde
authors.initials: H
authors.lastname: Hénon