title: Managing melancholic depression: a personal perspective.
abstract: OBJECTIVE
  The objective of this article is to offer a personal perspective on managing melancholia by interpreting both the limited salient evidence base and offering clinical observations.
  
  
  CONCLUSIONS
  It is suggested that medication needs to be prioritised, that not all antidepressants are equally potent for those with melancholia and that as response to a single antidepressant alone (especially a narrow-spectrum one) is low, management commonly requires broader-spectrum antidepressant drugs and augmentation strategies.
authors.affiliation: Scientia Professor of Psychiatry, University of New South Wales, Randwick, NSW, and; Professorial Fellow, Black Dog Institute, Randwick, NSW, Australia.
authors.forename: Gordon
authors.initials: G
authors.lastname: Parker
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy*; D019468:Disease Management; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006801:Humans
chemical_list: D000928:Antidepressive Agents
keywords: antidepressant drugs; augmentation; melancholia