title: Renal Clearable Organic Nanocarriers for Bioimaging and Drug Delivery.
abstract: Renally cleared zwitterionic nanocarriers (H-Dots) are composed of ε-polylysine backbone for charge variations, near-infrared fluorophores for bioimaging, and β-cyclodextrins for potential drug delivery. H-Dots show ideal systemic circulation and rapid distribution and excrete from normal tissue/organ via renal excretion after complete targeting to the tumor site without nonspecific uptake by the immune system.
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.
authors.forename: Homan
authors.initials: H
authors.lastname: Kang
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.|Institut Albert Bonniot, Université Grenoble Alpes, Grenoble, F-38000, France.|INSERM U1209, Grenoble, F-38000, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Gravier
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.
authors.forename: Kai
authors.initials: K
authors.lastname: Bao
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Wada
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.
authors.forename: Jeong Heon
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.
authors.forename: Yoonji
authors.initials: Y
authors.lastname: Baek
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.
authors.forename: Georges
authors.initials: G
authors.lastname: El Fakhri
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Gioux
authors.affiliation: Departments of Anatomic Pathology and Cancer Biology, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Lerner Research Institute and Taussig Cancer Center, Cleveland Clinic, Cleveland, OH, 44195, USA.
authors.forename: Brian P
authors.initials: BP
authors.lastname: Rubin
authors.affiliation: Institut Albert Bonniot, Université Grenoble Alpes, Grenoble, F-38000, France. jean-luc.coll@univ-grenoble-alpes.fr.|INSERM U1209, Grenoble, F-38000, France. jean-luc.coll@univ-grenoble-alpes.fr.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Coll
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA. hchoi12@mgh.harvard.edu.
authors.forename: Hak Soo
authors.initials: HS
authors.lastname: Choi
mesh_terms: D004337:Drug Carriers; D016503:Drug Delivery Systems; D005456:Fluorescent Dyes; D007668:Kidney; D053758:Nanoparticles; D047392:beta-Cyclodextrins
chemical_list: D004337:Drug Carriers; D005456:Fluorescent Dyes; D047392:beta-Cyclodextrins
keywords: drug delivery; nanoparticles; optical imaging; renal clearance; theranostics