title: Sleep Duration and White Matter Quality in Middle-Aged Adults.
abstract: Sleep duration has been associated with risk of dementia and stroke, but few studies have investigated the relationship between sleep duration and brain MRI measures, particularly in middle age.
  
  
  
  In a prospective cohort of 613 black and white adults (mean age = 45.4 years) enrolled in the Coronary Artery Risk Development in Young Adults (CARDIA) study, participants reported typical sleep duration, dichotomized into moderate sleep duration (> 6 to ≤ 8 h) and short sleep duration (≤ 6 h) at baseline (2005-2006). Five years later, we obtained brain MRI markers of white matter including fractional anisotropy, mean diffusivity, and white matter hyperintensities.
  
  
  
  Compared to moderate sleepers, short sleepers had an elevated ratio of white matter hyperintensities to normal tissue in the parietal region (OR = 2.31, 95% CI: 1.47, 3.61) adjusted for age, race/sex, education, hypertension, stroke/TIA, depression, smoking status, and physical activity. White matter diffusivity was also higher, approximately a 0.2 standard deviation difference, in frontal, parietal, and temporal white matter regions, among those reporting shorter sleep duration in (P < 0.05 for all).
  
  
  
  Short sleep duration was associated with worse markers of white matter integrity in midlife. These mid-life differences in white matter may underlie the link between poor sleep and risk of dementia and stroke.
authors.affiliation: Departments of Psychiatry, Neurology, Epidemiology and Biostatistics, University of California, San Francisco, CA and San Francisco VA Medical Center, San Francisco, CA.
authors.forename: Kristine
authors.initials: K
authors.lastname: Yaffe
authors.affiliation: Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA.
authors.forename: Ilya
authors.initials: I
authors.lastname: Nasrallah
authors.affiliation: Northern California Institute for Research and Education, San Francisco, CA.
authors.forename: Tina D
authors.initials: TD
authors.lastname: Hoang
authors.affiliation: Department of Public Health Sciences, University of Chicago, Chicago, IL.
authors.forename: Diane S
authors.initials: DS
authors.lastname: Lauderdale
authors.affiliation: Department of Medicine, University of Chicago, Chicago, IL.
authors.forename: Kristen L
authors.initials: KL
authors.lastname: Knutson
authors.affiliation: Department of Preventive Medicine, Northwestern University, Chicago, IL.
authors.forename: Mercedes R
authors.initials: MR
authors.lastname: Carnethon
authors.affiliation: Intramural Research Program, National Institute on Aging, Bethesda, MD.
authors.forename: Lenore J
authors.initials: LJ
authors.lastname: Launer
authors.affiliation: Department of Medicine, University of Alabama, Birmingham, AL.
authors.forename: Cora E
authors.initials: CE
authors.lastname: Lewis
authors.affiliation: Division of Research, Kaiser Permanente Northern California, Oakland, CA.
authors.forename: Stephen
authors.initials: S
authors.lastname: Sidney
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010296:Parietal Lobe / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D011446:Prospective Studies; D012890:Sleep / Q000502:physiology*; D012892:Sleep Deprivation / Q000473:pathology* / Q000503:physiopathology; D013997:Time Factors; D066127:White Matter / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D055815:Young Adult
keywords: midlife; sleep duration; white matter hyperintensities; white matter integrity