title: H3K4 acetylation, H3K9 acetylation and H3K27 methylation in breast tumor molecular subtypes.
abstract: Here, we investigated how the St Gallen breast molecular subtypes displayed distinct histone H3 profiles.
  
  
  
  192 breast tumors divided into five St Gallen molecular subtypes (luminal A, luminal B HER2-, luminal B HER2+, HER2+ and basal-like) were evaluated for their histone H3 modifications on gene promoters.
  
  
  
  ANOVA analysis allowed to identify specific H3 signatures according to three groups of genes: hormonal receptor genes (ERS1, ERS2, PGR), genes modifying histones (EZH2, P300, SRC3) and tumor suppressor gene (BRCA1). A similar profile inside high-risk cancers (luminal B [HER2+], HER2+ and basal-like) compared with low-risk cancers including luminal A and luminal B (HER2-) were demonstrated.
  
  
  
  The H3 modifications might contribute to clarify the differences between breast cancer subtypes.
authors.affiliation: Department of Oncogenetics, Centre Jean Perrin, CBRV, 28 Place Henri Dunant, 63001 Clermont-Ferrand, France.|EA 4677 'ERTICA', University of Auvergne, 63011 Clermont-Ferrand, France.
authors.forename: Gaëlle
authors.initials: G
authors.lastname: Judes
authors.affiliation: Department of Oncogenetics, Centre Jean Perrin, CBRV, 28 Place Henri Dunant, 63001 Clermont-Ferrand, France.|EA 4677 'ERTICA', University of Auvergne, 63011 Clermont-Ferrand, France.
authors.forename: Aslihan
authors.initials: A
authors.lastname: Dagdemir
authors.affiliation: Department of Oncogenetics, Centre Jean Perrin, CBRV, 28 Place Henri Dunant, 63001 Clermont-Ferrand, France.|EA 4677 'ERTICA', University of Auvergne, 63011 Clermont-Ferrand, France.|Department of Toxicology, Faculty of Pharmacy, Marmara University, 34668 Istanbul, Turkey.
authors.forename: Seher
authors.initials: S
authors.lastname: Karsli-Ceppioglu
authors.affiliation: University Blaise Pascal, Pascal Institute UMR 6602 CNRS/UBP, 63177 Aubière, France.
authors.forename: André
authors.initials: A
authors.lastname: Lebert
authors.affiliation: Department of Toxicology, Faculty of Pharmacy, Marmara University, 34668 Istanbul, Turkey.
authors.forename: Maureen
authors.initials: M
authors.lastname: Echegut
authors.affiliation: EA 4677 'ERTICA', University of Auvergne, 63011 Clermont-Ferrand, France.|Department of Toxicology, Faculty of Pharmacy, Marmara University, 34668 Istanbul, Turkey.
authors.forename: Marjolaine
authors.initials: M
authors.lastname: Ngollo
authors.affiliation: EA 4677 'ERTICA', University of Auvergne, 63011 Clermont-Ferrand, France.|Department of Toxicology, Faculty of Pharmacy, Marmara University, 34668 Istanbul, Turkey.
authors.forename: Yves-Jean
authors.initials: YJ
authors.lastname: Bignon
authors.affiliation: EA 4677 'ERTICA', University of Auvergne, 63011 Clermont-Ferrand, France.|Department of Biopathology, Centre Jean Perrin, 63011 Clermont-Ferrand, France.
authors.forename: Frédérique
authors.initials: F
authors.lastname: Penault-Llorca
authors.affiliation: Department of Oncogenetics, Centre Jean Perrin, CBRV, 28 Place Henri Dunant, 63001 Clermont-Ferrand, France.|EA 4677 'ERTICA', University of Auvergne, 63011 Clermont-Ferrand, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Bernard-Gallon
mesh_terms: D000107:Acetylation; D001943:Breast Neoplasms / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D042002:Chromatin Assembly and Disassembly; D044127:Epigenesis, Genetic; D005260:Female; D015870:Gene Expression; D015972:Gene Expression Regulation, Neoplastic; D006657:Histones / Q000378:metabolism*; D006801:Humans; D008745:Methylation; D011401:Promoter Regions, Genetic; D011499:Protein Processing, Post-Translational; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000378:metabolism
chemical_list: D006657:Histones; D018160:Receptors, Cytoplasmic and Nuclear
keywords: H3 modifications; St Gallen molecular subtypes; breast cancer