title: Comparison of Inflammatory Response to Transgastric and Transcolonic NOTES.
abstract: Aims. The aim of our study was to determine the physiologic impact of NOTES and to compare the transgastric and transcolonic approaches. Methods. Thirty pigs were randomized to transgastric, transcolonic, or laparoscopic peritoneoscopy. Blood was drawn and analyzed for C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin- (IL-) 1β, IL-6, WBCs, and platelets. Results. Endoscopic closure with an OTSC was successful in all 20 animals. The postoperative course was uneventful in all animals. CRP values rose on day 1 in all animals and slowly declined to baseline levels on day 14 with no differences between the groups (P > 0.05, NS). The levels of TNF-α were significantly increased in the transcolonic group (P < 0.01); however this difference was already present prior to the procedure and remained unchanged. No differences were observed in IL1-β and IL-6 values. There was a temporary rise of WBC on day 1 and of platelets on day 7 in all groups (P > 0.05, NS). Conclusions. Transgastric, transcolonic, and laparoscopic peritoneoscopy resulted in similar changes in systemic inflammatory markers. Our findings do not support the assumption that NOTES is less invasive than laparoscopy.
authors.affiliation: Department of Gastroenterology and Hepatology, Institute for Clinical and Experimental Medicine, Videnska 9, 14021 Prague, Czech Republic.
authors.forename: Tomas
authors.initials: T
authors.lastname: Hucl
authors.affiliation: Department of Gastroenterology and Hepatology, Institute for Clinical and Experimental Medicine, Videnska 9, 14021 Prague, Czech Republic.
authors.forename: Marek
authors.initials: M
authors.lastname: Benes
authors.affiliation: Department of Transplantation Surgery, Institute for Clinical and Experimental Medicine, Videnska 9, 14021 Prague, Czech Republic.
authors.forename: Matej
authors.initials: M
authors.lastname: Kocik
authors.affiliation: Institute of Microbiology, Academy of Science, Videnska 1083, 14021 Prague, Czech Republic.
authors.forename: Alla
authors.initials: A
authors.lastname: Splichalova
authors.affiliation: Department of Pathology, Institute for Clinical and Experimental Medicine, Videnska 9, 14021 Prague, Czech Republic.
authors.forename: Jana
authors.initials: J
authors.lastname: Maluskova
authors.affiliation: Department of Anesthesiology, Institute for Clinical and Experimental Medicine, Videnska 9, 14021 Prague, Czech Republic.
authors.forename: Martin
authors.initials: M
authors.lastname: Krak
authors.affiliation: Department of Statistics, Institute for Clinical and Experimental Medicine, Videnska 9, 14021 Prague, Czech Republic.
authors.forename: Vera
authors.initials: V
authors.lastname: Lanska
authors.affiliation: Department of Gastroenterology and Hepatology, Institute for Clinical and Experimental Medicine, Videnska 9, 14021 Prague, Czech Republic.
authors.forename: Marie
authors.initials: M
authors.lastname: Heczkova
authors.affiliation: Department of Anesthesiology, Institute for Clinical and Experimental Medicine, Videnska 9, 14021 Prague, Czech Republic.
authors.forename: Eva
authors.initials: E
authors.lastname: Kieslichova
authors.affiliation: Department of Transplantation Surgery, Institute for Clinical and Experimental Medicine, Videnska 9, 14021 Prague, Czech Republic.
authors.forename: Martin
authors.initials: M
authors.lastname: Oliverius
authors.affiliation: Department of Gastroenterology and Hepatology, Institute for Clinical and Experimental Medicine, Videnska 9, 14021 Prague, Czech Republic.
authors.forename: Julius
authors.initials: J
authors.lastname: Spicak