title: Near-Infrared-Emitting BODIPY-trisDOTA(111) In as a Monomolecular Multifunctional Imaging Probe: From Synthesis to In Vivo Investigations.
abstract: A new generation of monomolecular imaging probes (MOMIP) based on a distyryl-BODIPY (BODIPY=boron-dipyrromethene) coupled with three DOTA macrocycles has been prepared (DOTA=1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid). The MOMIP presents good fluorescence properties and is very stable in serum. The bimodal probe was conjugated to trastuzumab, and an optical in vivo study showed high accumulation of the imaging agent at the tumor site. (111) In radiometallation of the bioconjugate was performed in high radiochemical yield, highlighting the potential of this new BODIPY-chelators derivative as a bimodal imaging probe.
authors.affiliation: ICMUB UMR CNRS 6302, CNRS, Univ. Bourgogne Franche-Comté, 9, avenue Alain Savary, 21078, Dijon, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Maindron
authors.affiliation: ICMUB UMR CNRS 6302, CNRS, Univ. Bourgogne Franche-Comté, 9, avenue Alain Savary, 21078, Dijon, France.
authors.forename: Martin
authors.initials: M
authors.lastname: Ipuy
authors.affiliation: ICMUB UMR CNRS 6302, CNRS, Univ. Bourgogne Franche-Comté, 9, avenue Alain Savary, 21078, Dijon, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Bernhard
authors.affiliation: ICMUB UMR CNRS 6302, CNRS, Univ. Bourgogne Franche-Comté, 9, avenue Alain Savary, 21078, Dijon, France.
authors.forename: Damien
authors.initials: D
authors.lastname: Lhenry
authors.affiliation: ICMUB UMR CNRS 6302, CNRS, Univ. Bourgogne Franche-Comté, 9, avenue Alain Savary, 21078, Dijon, France.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Moreau
authors.affiliation: ICMUB UMR CNRS 6302, CNRS, Univ. Bourgogne Franche-Comté, 9, avenue Alain Savary, 21078, Dijon, France.
authors.forename: Sabin
authors.initials: S
authors.lastname: Carme
authors.affiliation: Centre Georges François Leclerc, Service de médecine nucléaire, 1 rue Professeur Marion, BP77980, 21079, Dijon Cedex, France.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Oudot
authors.affiliation: ICMUB UMR CNRS 6302, CNRS, Univ. Bourgogne Franche-Comté, 9, avenue Alain Savary, 21078, Dijon, France.|Centre Georges François Leclerc, Service de médecine nucléaire, 1 rue Professeur Marion, BP77980, 21079, Dijon Cedex, France.
authors.forename: Bertrand
authors.initials: B
authors.lastname: Collin
authors.affiliation: Centre Georges François Leclerc, Service de médecine nucléaire, 1 rue Professeur Marion, BP77980, 21079, Dijon Cedex, France.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Vrigneaud
authors.affiliation: Oncodesign, 20 rue Jean Mazen, BP27627, 21076, Dijon CEDEX, France.
authors.forename: Peggy
authors.initials: P
authors.lastname: Provent
authors.affiliation: Centre Georges François Leclerc, Service de médecine nucléaire, 1 rue Professeur Marion, BP77980, 21079, Dijon Cedex, France.
authors.forename: François
authors.initials: F
authors.lastname: Brunotte
authors.affiliation: ICMUB UMR CNRS 6302, CNRS, Univ. Bourgogne Franche-Comté, 9, avenue Alain Savary, 21078, Dijon, France. franck.denat@u-bourgogne.fr.
authors.forename: Franck
authors.initials: F
authors.lastname: Denat
authors.affiliation: ICMUB UMR CNRS 6302, CNRS, Univ. Bourgogne Franche-Comté, 9, avenue Alain Savary, 21078, Dijon, France. christine.goze@u-bourgogne.fr.
authors.forename: Christine
authors.initials: C
authors.lastname: Goze
keywords: BODIPY; DOTA; MOMIP; bimodal probes; optical imaging