title: The effect of preoperative Lugol's iodine on intraoperative bleeding in patients with hyperthyroidism.
abstract: OBJECTIVE
  To investigate the effect of preoperative Lugol's iodine on intraoperative bleeding in patients with hyperthyroidism.
  
  
  METHODS
  This controlled, randomized, prospective cohort was carried out on 40 patients who admitted for surgery due to hyperthyroidism. Cases were randomly assigned to receive either preoperative treatment with Lugol solution (Group 1) or no preoperative treatment with Lugol solution (Group 2). Group 3 (n = 10) consisted of healthy adults with no known history and signs of hyperthyroidism. Blood flow through the thyroid arteries of patients was measured by color flow Doppler ultrasonography. Free T3, free T4, TSH, thyroid volume and the resistance index of the four main thyroid arteries were measured in all patients.
  
  
  RESULTS
  There was not a significant difference between gender, preoperative serum thyroid hormone levels, or thyroid gland volumes between groups 1 and 2. The mean blood flow of the patients in Group 1 was significantly lower than values in Group 2. When age, gender, thyroid hormone, TSH, thyroid volume, blood flow, and Lugol solution treatment were included as independent variables, Lugol solution treatment (OR, 7.40; 95% CI, 1.02-58.46; p = 0.001) was found to be the only significant independent determinant of intraoperative blood loss. Lugol solution treatment resulted in a 7.40-fold decrease in the rate of intraoperative blood loss.
  
  
  CONCLUSIONS
  Preoperative Lugol solution treatment was found to be a significant independent determinant of intraoperative blood loss. Moreover, preoperative Lugol solution treatment decreased the rate of blood flow, and intraoperative blood loss during thyroidectomy.
authors.affiliation: Department of General Surgery, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey.
authors.forename: Yeliz
authors.initials: Y
authors.lastname: Yilmaz
authors.affiliation: Department of General Surgery, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey.
authors.forename: Kemal Erdinc
authors.initials: KE
authors.lastname: Kamer
authors.affiliation: Department of General Surgery, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey.
authors.forename: Orhan
authors.initials: O
authors.lastname: Ureyen
authors.affiliation: Department of General Surgery, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey.
authors.forename: Erdem
authors.initials: E
authors.lastname: Sari
authors.affiliation: Department of General Surgery, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey.
authors.forename: Turan
authors.initials: T
authors.lastname: Acar
authors.affiliation: Department of General Surgery, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey.
authors.forename: Onder
authors.initials: O
authors.lastname: Karahalli
keywords: Bleeding; Hyperthyroidism; Intraoperative; Lugol's iodine