title: Therapeutic Potential of Genipin in Central Neurodegenerative Diseases.
abstract: Central neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD), are one of the biggest health problems worldwide. Currently, there is no cure for these diseases. The Gardenia jasminoides fruit is a common herbal medicine in traditional Chinese medicine (TCM), and a variety of preparations are used as treatments for central nervous system (CNS) diseases. Pharmacokinetic studies suggest genipin is one of the main effective ingredients of G. jasminoides fruit extract (GFE). Accumulated research data show that genipin possesses a range of key pharmacological properties, such as anti-inflammatory, neuroprotective, neurogenic, antidiabetic, and antidepressant effects. Thus, genipin shows therapeutic potential for central neurodegenerative diseases. We review the pharmacological actions of genipin for the treatment of neurodegenerative diseases of the CNS. We also describe the potential mechanisms underlying these effects.
authors.affiliation: Key Laboratory of Cellular Physiology, Medical Faculty, Shanxi Medical University, Taiyuan, 030001, Shanxi, People's Republic of China.|Department of Human Anatomy, Shaoyang Medical College, Shaoyang, Hunan, People's Republic of China.
authors.forename: Yanwei
authors.initials: Y
authors.lastname: Li
authors.affiliation: Key Laboratory of Cellular Physiology, Medical Faculty, Shanxi Medical University, Taiyuan, 030001, Shanxi, People's Republic of China. linlilin999@163.com.
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.affiliation: Biomedical and Life Science, Faculty of Health and Medicine, Lancaster University, Lancaster, LA1 4YQ, UK.|Second Hospital, Shanxi Medical University, Taiyuan, Shanxi, People's Republic of China.
authors.forename: Christian
authors.initials: C
authors.lastname: Hölscher
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000627:therapeutic use; D039823:Iridoids / Q000737:chemistry / Q000627:therapeutic use*; D009414:Nerve Growth Factors / Q000737:chemistry / Q000627:therapeutic use; D019636:Neurodegenerative Diseases / Q000188:drug therapy*; D018696:Neuroprotective Agents / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D000893:Anti-Inflammatory Agents; D007004:Hypoglycemic Agents; D039823:Iridoids; D009414:Nerve Growth Factors; D018696:Neuroprotective Agents; C007834:genipin