title: The clinical symptoms of Parkinson's disease.
abstract: In this review, the clinical features of Parkinson's disease, both motor and non-motor, are described in the context of the progression of the disease. Also briefly discussed are the major treatment strategies and their complications. Parkinson's disease is a slowly progressing neurodegenerative disorder, causing impaired motor function with slow movements, tremor and gait and balance disturbances. A variety of non-motor symptoms are common in Parkinson's disease. They include disturbed autonomic function with orthostatic hypotension, constipation and urinary disturbances, a variety of sleep disorders and a spectrum of neuropsychiatric symptoms. This article describes the different clinical symptoms that may occur and the clinical course of the disease. This article is part of a special issue on Parkinson disease.
authors.affiliation: Department of Neurology, Broomfield Hospital, Chelmsford, Essex, CM1 7ET, UK. sigurlaug.sveinbjornsdottir@meht.nhs.uk.|Queen Mary School of Medicine and Dentistry, University of London, London, UK. sigurlaug.sveinbjornsdottir@meht.nhs.uk.
authors.forename: Sigurlaug
authors.initials: S
authors.lastname: Sveinbjornsdottir
mesh_terms: D000818:Animals; D018450:Disease Progression; D020233:Gait Disorders, Neurologic / Q000503:physiopathology / Q000523:psychology; D006801:Humans; D001523:Mental Disorders / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology; D010300:Parkinson Disease / Q000175:diagnosis* / Q000503:physiopathology* / Q000523:psychology; D012893:Sleep Wake Disorders / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology; D014202:Tremor / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology
keywords: Parkinson's disease; clinical symptoms; dopamine; therapy