title: Air Pressure, Humidity and Stroke Occurrence: A Systematic Review and Meta-Analysis.
abstract: An influence of climate upon stroke risk is biologically plausible and supported by epidemiological evidence. We aimed to determine whether air pressure (AP) and humidity are associated with hospital stroke admission.
  
  
  
  We searched MEDLINE, Embase, PsycINFO, CINAHL, Web of Science, and GEOBASE, from inception to 16 October 2015 to identify relevant population-based observational studies. Where possible, data were pooled for meta-analysis with odds ratios (OR) and corresponding 95% confidence intervals (CI) by means of the random-effect method.
  
  
  
  We included 11 studies with a total of 314,385 patients. The effect of AP was varied across studies for ischemic stroke (IS) and subarachnoid haemorrhage (SAH). Pooled ORs (95%CI) associated with 1 hPa increase in AP for the risk of IS, intracerebral hemorrhage (ICH) and SAH were 1.00 (0.99-1.01), 1.01 (0.99-1.02) and 1.02 (0.97-1.07) respectively. The pooled ORs (95%CI) associated with 1 percent increase in humidity for the risk of IS and ICH were 1.00 (1.00-1.01) and 1.00 (0.99-1.01) respectively.
  
  
  
  This review shows that there is no evidence of a relationship between AP or humidity and the occurrence of hospital admission for stroke. Further research is needed to clarify the extent and nature of any relationship between AP, humidity and stroke in different geographical areas.
authors.affiliation: Department of Neurology, The Second Affiliated Hospital of Soochow University, No.1055, Sanxiang Rd., Suzhou 215004, China. yongjuncao@126.com.
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Cao
authors.affiliation: The George Institute for Global Health, P.O. Box M201, Missenden Road, Sydney, NSW 2050, Australia. xwang@georgeinstitute.org.au.|Sydney Medical School, The University of Sydney, Sydney, NSW 2050, Australia. xwang@georgeinstitute.org.au.
authors.forename: Xia
authors.initials: X
authors.lastname: Wang
authors.affiliation: The George Institute for Global Health, P.O. Box M201, Missenden Road, Sydney, NSW 2050, Australia. dzheng@georgeinstitute.org.au.|Sydney Medical School, The University of Sydney, Sydney, NSW 2050, Australia. dzheng@georgeinstitute.org.au.
authors.forename: Danni
authors.initials: D
authors.lastname: Zheng
authors.affiliation: Department of Cardiovascular Sciences and NIHR Biomedical Research Unit for Cardiovascular Diseases, University of Leicester, Leicester LE1 7RH, UK. tgr2@leicester.ac.uk.
authors.forename: Thompson
authors.initials: T
authors.lastname: Robinson
authors.affiliation: Division of Nephrology, Sichuan Academy of Medical Sciences &amp; Sichuan Provincial People's Hospital, Chengdu 610072, China. hongdaqing11@126.com.
authors.forename: Daqing
authors.initials: D
authors.lastname: Hong
authors.affiliation: The George Institute for Global Health, P.O. Box M201, Missenden Road, Sydney, NSW 2050, Australia. srichtering@georgeinstitute.org.au.
authors.forename: Sarah
authors.initials: S
authors.lastname: Richtering
authors.affiliation: The George Institute for Global Health, P.O. Box M201, Missenden Road, Sydney, NSW 2050, Australia. hugh-96@hotmail.com.
authors.forename: Tzen Hugh
authors.initials: TH
authors.lastname: Leong
authors.affiliation: The George Institute for Global Health, P.O. Box M201, Missenden Road, Sydney, NSW 2050, Australia. asalam@georgeinstitute.org.au.|Sydney Medical School, The University of Sydney, Sydney, NSW 2050, Australia. asalam@georgeinstitute.org.au.
authors.forename: Abdul
authors.initials: A
authors.lastname: Salam
authors.affiliation: The George Institute for Global Health, P.O. Box M201, Missenden Road, Sydney, NSW 2050, Australia. canderson@georgeinstitute.org.au.|Department of Neurology, Royal Prince Alfred Hospital, Syndey, NSW 2050, Australia. canderson@georgeinstitute.org.au.
authors.forename: Craig
authors.initials: C
authors.lastname: Anderson
authors.affiliation: The George Institute for Global Health, P.O. Box M201, Missenden Road, Sydney, NSW 2050, Australia. mhackett@georgeinstitute.org.au.|College of Health and Wellbeing, The University of Central Lancashire, Preston PR1 2HE, UK. mhackett@georgeinstitute.org.au.
authors.forename: Maree L
authors.initials: ML
authors.lastname: Hackett
mesh_terms: D000399:Air Pressure; D002543:Cerebral Hemorrhage / Q000453:epidemiology; D006801:Humans; D006813:Humidity; D020521:Stroke / Q000453:epidemiology*; D013345:Subarachnoid Hemorrhage / Q000453:epidemiology
keywords: air pressure; humidity; stroke; systematic review; weather