title: Japanese version of the ALS-FTD-Questionnaire (ALS-FTD-Q-J).
abstract: Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) share common clinical, genetic and neuropathological features. Some ALS patients have behavioral/personality changes, which could result in significant obstacles in the care provided by family members and caregivers. An easy screening tool would contribute greatly to the evaluation of these symptoms. We translated the ALS-FTD-Questionnaire, developed in the Netherlands, into Japanese (ALS-FTD-Q-J) and examined the clinimetric properties (internal consistency, construct and clinical validity). Patients with ALS and/or behavioral variant FTD (bvFTD) were evaluated alongside healthy controls in this multicenter study. All ALS patients, regardless of bvFTD status, were further evaluated by the frontal behavioral inventory (FBI) and for frontal/executive function, cognition, anxiety/depression, and motor functions. Data from 146 subjects were analyzed: ALS (92), ALS-bvFTD (6), bvFTD (16), and healthy controls (32). The internal consistency of the ALS-FTD-Q-J was good (Cronbach α=0.92). The ALS-FTD-Q-J showed construct validity as it exhibited a high correlation with the FBI (r=0.79). However, correlations were moderate with anxiety/depression and low with cognitive scales, in contrast to the original report, i.e. a moderate correlation with cognition and a low correlation with anxiety/depression. The ALS-FTD-Q-J discriminated ALS patients from (ALS-)bvFTD patients and controls. Thus, the ALS-FTD-Q-J is useful for evaluating Japanese ALS/FTD patients.
authors.affiliation: Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University, Yonago, Japan. Electronic address: yawatana@med.tottori-u.ac.jp.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Watanabe
authors.affiliation: Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands.
authors.forename: Emma
authors.initials: E
authors.lastname: Beeldman
authors.affiliation: Department of Neurology, Radboud UMC, Nijmegen, The Netherlands.
authors.forename: Joost
authors.initials: J
authors.lastname: Raaphorst
authors.affiliation: Department of Clinical Neuroscience, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
authors.forename: Yuishin
authors.initials: Y
authors.lastname: Izumi
authors.affiliation: Yoshino Neurology Clinic, Ichikawa, Japan.
authors.forename: Hiide
authors.initials: H
authors.lastname: Yoshino
authors.affiliation: Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Michihito
authors.initials: M
authors.lastname: Masuda
authors.affiliation: Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Atsuta
authors.affiliation: Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University, Yonago, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Ito
authors.affiliation: Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University, Yonago, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Adachi
authors.affiliation: Department of Neurology, National Hospital Organization, Matsue Medical Center, Matsue, Japan.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Adachi
authors.affiliation: Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Yokota
authors.affiliation: Department of Neurology, Vihara Hananosato Hospital, Miyoshi, Japan.
authors.forename: Masaya
authors.initials: M
authors.lastname: Oda
authors.affiliation: Department of Neurology, Kitasato University School of Medicine, Kanagawa, Japan.
authors.forename: Ritsuko
authors.initials: R
authors.lastname: Hanashima
authors.affiliation: Kitasato University, Department of Comprehensive Medicine, Division of Integrated Care and Whole Person Care, Kanagawa, Japan.
authors.forename: Mieko
authors.initials: M
authors.lastname: Ogino
authors.affiliation: Department of Neurology, Showa University Fujigaoka Hospital, Kanagawa, Japan.
authors.forename: Hiroo
authors.initials: H
authors.lastname: Ichikawa
authors.affiliation: National Hospital Organization, Sagamihara National Hospital, Kanagawa, Japan.
authors.forename: Kazuko
authors.initials: K
authors.lastname: Hasegawa
authors.affiliation: Department of Neurology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Kimura
authors.affiliation: Department of Neurology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan.
authors.forename: Toshio
authors.initials: T
authors.lastname: Shimizu
authors.affiliation: Department of Neurology, National Hospital Organization, Higashi Nagoya National Hospital, Nagoya, Japan.
authors.forename: Ikuko
authors.initials: I
authors.lastname: Aiba
authors.affiliation: Department of Neurology and Clinical Pharmacology, Ehime University Graduate School of Medicine, Ehime, Japan.
authors.forename: Hayato
authors.initials: H
authors.lastname: Yabe
authors.affiliation: Yodoe Clinic, Yonago, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Kanba
authors.affiliation: Department of Neurology, San-in Rosai Hospital, Yonago, Japan.
authors.forename: Kimiyoshi
authors.initials: K
authors.lastname: Kusumi
authors.affiliation: Akasaki Medical Office, Kotoura, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Aoki
authors.affiliation: Division of Neuropsychiatry, Yowa Hospital, Yonago, Japan.
authors.forename: Yu
authors.initials: Y
authors.lastname: Hiroe
authors.affiliation: Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Watanabe
authors.affiliation: Department of Neurology, Kitasato University School of Medicine, Kanagawa, Japan.
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Nishiyama
authors.affiliation: Department of Neurology and Clinical Pharmacology, Ehime University Graduate School of Medicine, Ehime, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nomoto
authors.affiliation: Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Gen
authors.initials: G
authors.lastname: Sobue
authors.affiliation: Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University, Yonago, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Nakashima
mesh_terms: D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D017028:Caregivers; D003937:Diagnosis, Differential; D004644:Emotions; D005190:Family; D005260:Female; D057180:Frontotemporal Dementia / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D006801:Humans; D008297:Male; D009043:Motor Activity; D010865:Pilot Projects; D019727:Proxy; D011795:Surveys and Questionnaires; D014177:Translations
keywords: Amyotrophic lateral sclerosis; Behavioral and personality abnormalities; Caregivers; Family members; Frontotemporal dementia; Questionnaire