title: Chemical Constituents Isolated from the Root Bark of Cudrania tricuspidata and Their Potential Neuroprotective Effects.
abstract: Seventy-five compounds, including 21 new compounds (1-21), were isolated from the root bark of Cudrania tricuspidata. The structures of the isolated compounds were elucidated by interpretation of their spectroscopic data. All isolated compounds were evaluated for their neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced cell death, and nine compounds had activities with EC50 values of 1.9-30.2 μM. The 75 isolated compounds along with 34 previously reported xanthones were tested also for neuroprotective effects against the 1-methyl-4-phenylpyridinium ion (MPP(+)) and oxygen glucose deprivation (OGD)-induced cell death. Three compounds were active against MPP(+)-induced cell death with EC50 values of 0.2-10.3 μM, and 23 compounds were active in the OGD model with EC50 values of 2.9-35.5 μM.
authors.forename: Jaeyoung
authors.initials: J
authors.lastname: Kwon
authors.forename: Nguyen Tuan
authors.initials: NT
authors.lastname: Hiep
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University , Seoul 08826, Republic of Korea.
authors.forename: Dong-Woo
authors.initials: DW
authors.lastname: Kim
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University , Seoul 08826, Republic of Korea.
authors.forename: Sungeun
authors.initials: S
authors.lastname: Hong
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University , Tianjin 300071, People's Republic of China.
authors.forename: Yuanqiang
authors.initials: Y
authors.lastname: Guo
authors.affiliation: College of Pharmacy, Chungbuk National University , Cheongju 28644, Republic of Korea.
authors.forename: Bang Yeon
authors.initials: BY
authors.lastname: Hwang
authors.affiliation: Korea Forest Research Institute , Seoul 02455, Republic of Korea.
authors.forename: Hak Ju
authors.initials: HJ
authors.lastname: Lee
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University , Seoul 08826, Republic of Korea.
authors.forename: Woongchon
authors.initials: W
authors.lastname: Mar
authors.forename: Dongho
authors.initials: D
authors.lastname: Lee
mesh_terms: D000818:Animals; D016923:Cell Death / Q000187:drug effects; D004195:Disease Models, Animal; D005947:Glucose / Q000378:metabolism; D007511:Ischemia / Q000188:drug therapy; D029586:Moraceae / Q000737:chemistry*; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019906:Nuclear Magnetic Resonance, Biomolecular; D010300:Parkinson Disease / Q000188:drug therapy*; D024301:Plant Bark / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*; D056910:Republic of Korea; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D018696:Neuroprotective Agents; D044004:Xanthones; D005947:Glucose