title: Pluripotent stem cells as a model for embryonic patterning: From signaling dynamics to spatial organization in a dish.
abstract: In vivo studies have identified the signaling pathways and transcription factors involved in patterning the vertebrate embryo, but much remains unknown about how these are organized in space and time to orchestrate embryogenesis. Recently, embryonic stem cells have been established as a platform for studying spatial pattern formation and differentiation dynamics in the early mammalian embryo. The ease of observing and manipulating stem cell systems promises to fill gaps in our understanding of developmental dynamics and identify aspects that are uniquely human. Developmental Dynamics 245:976-990, 2016. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Department of Biosciences, Rice University, Houston, Texas.
authors.forename: Idse
authors.initials: I
authors.lastname: Heemskerk
authors.affiliation: Department of Biosciences, Rice University, Houston, Texas. aryeh.warmflash@rice.edu.|Department of Bioengineering, Rice University, Houston, Texas. aryeh.warmflash@rice.edu.
authors.forename: Aryeh
authors.initials: A
authors.lastname: Warmflash
mesh_terms: D000818:Animals; D019521:Body Patterning / Q000235:genetics / Q000502:physiology*; D002454:Cell Differentiation / Q000235:genetics / Q000502:physiology; D004622:Embryo, Mammalian / Q000166:cytology / Q000378:metabolism / Q000502:physiology; D053595:Embryonic Stem Cells / Q000166:cytology / Q000378:metabolism / Q000502:physiology; D018507:Gene Expression Regulation, Developmental / Q000235:genetics / Q000502:physiology; D006801:Humans; D039904:Pluripotent Stem Cells / Q000166:cytology* / Q000378:metabolism / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology
keywords: dynamics; gastrulation; human embryonic stem cells; morphogen; signaling