title: Oct4B, CD90, and CD73 are upregulated in bladder tissue following electro-resection of the bladder.
abstract: OBJECTIVE
  We tested the hypothesis that stimulation by electro-resection of bladder tissue induces stem cells in the tissue repair process.
  
  
  METHODS
  After primary transurethral resection of a bladder tumor and surrounding tissue (TUR-Bt), second TUR-Bt was performed. Tissues excised by second TUR-Bt were immunohistochemically stained for Oct4, a marker of pluripotency, and for CD90 and CD73, markers of mesenchymal stromal cells, when no bladder tumor cells remained.
  
  
  CONCLUSIONS
  Oct4B protein was sporadically stained in the cytoplasm of interstitial cells in four out of eight cases. CD90 and CD73 are upregulated in interstitial and vascular endothelial cells without CD45 expression. Mesenchymal stromal cells, but not pluripotent stem cells, may be mainly involved in bladder tissue repair.
authors.affiliation: Department of Urology, Kanto Rosai Hospital, Kizukisumiyoshi-cho, Nakahara-ku, Kawasaki, Japan.
authors.forename: Takumi
authors.initials: T
authors.lastname: Takeuchi
authors.affiliation: Department of Pathology, Kanto Rosai Hospital, Kizukisumiyoshi-cho, Nakahara-ku, Kawasaki, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Tonooka
authors.affiliation: Department of Urology, Kanto Rosai Hospital, Kizukisumiyoshi-cho, Nakahara-ku, Kawasaki, Japan.
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Okuno
authors.affiliation: Department of Urology, Kanto Rosai Hospital, Kizukisumiyoshi-cho, Nakahara-ku, Kawasaki, Japan.
authors.forename: Mami
authors.initials: M
authors.lastname: Hattori-Kato
authors.affiliation: Department of Urology, Kanto Rosai Hospital, Kizukisumiyoshi-cho, Nakahara-ku, Kawasaki, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Mikami
keywords: Bladder; CD73; CD90; Electric; Oct4B; Stimulation