title: Risk of Cerebral Infarction in Japanese Hemodialysis Patients: Miyazaki Dialysis Cohort Study (MID study).
abstract: OBJECTIVE
  Predictors including the preventive effects of antiplatelet and anticoagulant drugs on cerebral infarction (CI) events have not yet been clarified in dialysis patients. The aim of the present study was to examine the risk of CI and preventive effects of these drugs in Japanese hemodialysis patients.
  
  
  METHODS
  Patients receiving maintenance hemodialysis (n=1,551, median age (interquartile range), 69.0 (59.0-78.0) years; 41.5% female) were enrolled in the Miyazaki Dialysis Cohort Study and prospectively followed-up for 3 years. Kaplan-Meier and Cox's regression analyses were used to clarify the risk of CI.
  
  
  RESULTS
  Eighty-four patients developed CI at an incidence of 21.5/1000 patients per year. The presence of a previous history of CI, atrial fibrillation (AF), and diabetes mellitus in addition to age were also identified as predictive factors for new CI, whereas no relationship was observed between antiplatelet and/or anticoagulant usage and CI. Furthermore, no significant difference was noted in the frequency of CI events between patients with AF who received warfarin and those who did not.
  
  
  CONCLUSIONS
  The incidence of CI was higher in dialysis patients with a previous history of CI and AF; however, the preventive effects of antiplatelet/anticoagulant drugs on the development of CI were not evident.
authors.affiliation: Division of Circulatory and Body Fluid Regulation, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
authors.forename: Tatsunori
authors.initials: T
authors.lastname: Toida
authors.forename: Yuji
authors.initials: Y
authors.lastname: Sato
authors.forename: Hideto
authors.initials: H
authors.lastname: Nakagawa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Komatsu
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Uezono
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Yamada
authors.forename: Tabito
authors.initials: T
authors.lastname: Ishihara
authors.forename: Shuichi
authors.initials: S
authors.lastname: Hisanaga
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kitamura
authors.forename: Shouichi
authors.initials: S
authors.lastname: Fujimoto
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000494:pharmacology; D044466:Asian People; D001281:Atrial Fibrillation; D002544:Cerebral Infarction / Q000188:drug therapy* / Q000209:etiology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000150:complications / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D006435:Renal Dialysis; D012307:Risk Factors
chemical_list: D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors