title: Three new resin glycosides compounds from Argyreia acuta and their α-glucosidase inhibitory activity.
abstract: Three new phenolic compounds, acutacoside C (1), acutacoside D (2) and acutacoside E (3) were isolated from the aerial part of Argyreia acuta. The oligosaccharide chain was composed of two glucoses and three rhamnoses, and the aglycone was (11S)-hydroxyhexadecanoic acid (jalapinolic acid). The core of the three compounds was operculinic acid B, which was rare in resin glycosides. Their structures were established by a combination of spectroscopic and chemical methods. Compounds 1-3 have been evaluated for inhibitory activity against α-glucosidase, which all showed weak inhibitory activities.
authors.affiliation: a School of Traditional Chinese Medicinal Chemistry , Guangdong Pharmaceutical University , Guangzhou , People's Republic China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: a School of Traditional Chinese Medicinal Chemistry , Guangdong Pharmaceutical University , Guangzhou , People's Republic China.
authors.forename: You-Shao
authors.initials: YS
authors.lastname: Yan
authors.affiliation: a School of Traditional Chinese Medicinal Chemistry , Guangdong Pharmaceutical University , Guangzhou , People's Republic China.
authors.forename: Hong-Hua
authors.initials: HH
authors.lastname: Cui
authors.affiliation: a School of Traditional Chinese Medicinal Chemistry , Guangdong Pharmaceutical University , Guangzhou , People's Republic China.
authors.forename: Yong-Qin
authors.initials: YQ
authors.lastname: Yin
authors.affiliation: a School of Traditional Chinese Medicinal Chemistry , Guangdong Pharmaceutical University , Guangzhou , People's Republic China.
authors.forename: Jie-Tao
authors.initials: JT
authors.lastname: Pan
authors.affiliation: a School of Traditional Chinese Medicinal Chemistry , Guangdong Pharmaceutical University , Guangzhou , People's Republic China.
authors.forename: Bang-Wei
authors.initials: BW
authors.lastname: Yu
mesh_terms: D027722:Convolvulaceae / Q000737:chemistry*; D065089:Glycoside Hydrolase Inhibitors / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D035261:Plant Components, Aerial / Q000737:chemistry; D012116:Resins, Plant / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D065089:Glycoside Hydrolase Inhibitors; D006027:Glycosides; D012116:Resins, Plant
keywords: Argyreia acuta; resin glycosides; structural identification; α-glucosidase