title: ESI-MS studies of the non-covalent interactions between biologically important metal ions and N-sulfonylcytosine derivatives.
abstract: The aim of this report is to present the electrospray ionization mass spectrometry results of the non-covalent interaction of two biologically active ligands, N-1-(p-toluenesulfonyl)cytosine, 1-TsC, 1 and N-1-methanesulfonylcytosine, 1-MsC, 2 and their Cu(II) complexes Cu(1-TsC-N3)2Cl2, 3 and Cu(1-MsC-N3)2Cl2and 4 with biologically important cations: Na+, K+, Ca2+, Mg2+and Zn2+. The formation of various complex metal ions was observed. The alkali metals Na+and K+formed clusters because of electrostatic interactions. Ca2+and Mg2+salts produced the tris ligand and mixed ligand complexes. The interaction of Zn2+with 1-4 produced monometal and dimetal Zn2+complexes as a result of the affinity of Zn2+ions toward both O and N atoms. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Ministry of Defense of the Republic of Croatia, "Dr. Franjo Tuđman" Croatian Defense Academy, Ilica 256 b, Zagreb, Croatia.
authors.forename: Valentina
authors.initials: V
authors.lastname: Ključarić
authors.affiliation: Laboratory for Biomolecular Interactions and Spectroscopy, Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička cesta 54, 10 000, Zagreb, Croatia. rkobetic@irb.hr.
authors.forename: Renata
authors.initials: R
authors.lastname: Kobetić
authors.affiliation: Institute for Medical Research and Occupational Health, Ksaverska cesta 2, 10 000, Zagreb, Croatia.
authors.forename: Jasmina
authors.initials: J
authors.lastname: Rinkovec
authors.affiliation: Laboratory for Chemical Kinetics and Atmospheric Chemistry, Division of Physical Chemistry, Ruđer Bošković Institute, Bijenička cesta 54, 10 000, Zagreb, Croatia.
authors.forename: Snježana
authors.initials: S
authors.lastname: Kazazić
authors.affiliation: Fidelta d.o.o., Prilaz baruna Filipovića 29, 10 000, Zagreb, Croatia.
authors.forename: Dubravka
authors.initials: D
authors.lastname: Gembarovski
authors.affiliation: Laboratory for Biomolecular Interactions and Spectroscopy, Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička cesta 54, 10 000, Zagreb, Croatia.
authors.forename: Dijana
authors.initials: D
authors.lastname: Saftić
authors.affiliation: Laboratory for Biomolecular Interactions and Spectroscopy, Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička cesta 54, 10 000, Zagreb, Croatia.
authors.forename: Josipa
authors.initials: J
authors.lastname: Matić
authors.affiliation: Laboratory for Biomolecular Interactions and Spectroscopy, Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička cesta 54, 10 000, Zagreb, Croatia.
authors.forename: Željka
authors.initials: Ž
authors.lastname: Ban
authors.affiliation: Laboratory for Biomolecular Interactions and Spectroscopy, Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička cesta 54, 10 000, Zagreb, Croatia. bzinic@irb.hr.
authors.forename: Biserka
authors.initials: B
authors.lastname: Žinić
mesh_terms: D002412:Cations / Q000737:chemistry; D056831:Coordination Complexes / Q000737:chemistry; D003596:Cytosine / Q000031:analogs & derivatives* / Q000737:chemistry*; D008024:Ligands; D008670:Metals / Q000737:chemistry*; D009584:Nitrogen; D010100:Oxygen; D021241:Spectrometry, Mass, Electrospray Ionization; D055672:Static Electricity; D053719:Tandem Mass Spectrometry
chemical_list: D002412:Cations; D056831:Coordination Complexes; D008024:Ligands; D008670:Metals; D003596:Cytosine; D009584:Nitrogen; D010100:Oxygen
keywords: Cu(II) complexes; ESI-MS; N-1-sulfonylcytosine derivatives; metal ions Na+, K+, Ca2+, Mg2+ and Zn2+; non-covalent interactions