title: Changes in Body Image in Patients with Prostate Cancer over 2 Years of Treatment with a Gonadotropin-Releasing Hormone Analogue (Triptorelin): Results from a Belgian Non-Interventional Study.
abstract: BACKGROUND
  Androgen deprivation therapy has been associated with worsened body image in prostate cancer patients. Body image and physical presentation changes were investigated in patients receiving a gonadotropin-releasing hormone analogue (triptorelin) as part of treatment for locally advanced or metastatic prostate cancer.
  
  
  OBJECTIVE
  The aim was to evaluate the changes in self-perception of the body and to assess the relationship of these changes over a period of 2 years in men treated with triptorelin as primary therapy for advanced or locally advanced prostate cancer.
  
  
  METHODS
  Data were collected for 2 years in accordance with routine clinical practice. Body image was assessed using the body image scale (BIS). Patient body mass index (BMI) and waist circumference were also measured.
  
  
  RESULTS
  BIS and BMI data for both baseline and a least one post-baseline visit were available for 98 of the 145 patients enrolled. The median change in BIS score for patients assessed around 12 or 24 months after baseline and at the last observation was zero, indicating no body image deterioration in at least half of patients. Statistically significant BIS score increases were detected in assessments around 6, 12 and 18 months, but not after 2 years, indicating some patients experienced body image deterioration at some point during treatment. Changes in BMI from baseline were modest and generally not statistically significant. Waist circumference increased during the study (mean ± standard deviation increase of 1.00 ± 5.01 cm at the last observation). Positive correlations were determined between increases in BIS score and both BMI and waist circumference (r= 0.235 and 0.267, respectively;p= 0.020 and 0.008) at the last observation for all patients, as well as during the second year of the study.
  
  
  CONCLUSIONS
  Most patients did not experience clinically meaningful worsening of body image perception during the study. BMI and waist circumference had a modest impact on body image during study year 2.
authors.affiliation: CVBA Medizorg, Bredene, Belgium.
authors.forename: Hans
authors.initials: H
authors.lastname: van den Driessche
authors.affiliation: AZ Damiaan, Campus St Jozef, Oostende, Belgium.
authors.forename: Pieter
authors.initials: P
authors.lastname: Mattelaer
authors.affiliation: AZ St Jan, Brugge, Belgium.
authors.forename: Peter
authors.initials: P
authors.lastname: van Oyen
authors.affiliation: AZ Delta, Roeselare, Belgium.
authors.forename: Wouter
authors.initials: W
authors.lastname: Marchand
authors.affiliation: Avenue Winston Churchill 5, Brussels, Belgium.
authors.forename: Ovadia
authors.initials: O
authors.lastname: Bar-Moshé
authors.affiliation: AZ St Lucas, Ghent, Belgium.
authors.forename: Luc
authors.initials: L
authors.lastname: Merckx
authors.affiliation: AZ Groenige, Campus Sint-Maarten, Kortrijk, Belgium.
authors.forename: Ignace
authors.initials: I
authors.lastname: Billiet
authors.affiliation: Ipsen Pharma, Boulogne Billancourt, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Cabri
authors.affiliation: Ipsen Pharma, Boulogne Billancourt, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Maisonobe
authors.affiliation: Ipsen NV, Guldensporenpark 87, 9820 Merelbeke, Belgium.
authors.forename: Vincent
authors.initials: V
authors.lastname: De Ruyter
authors.affiliation: UZ Brussel, Brussels, Belgium.
authors.forename: Johan
authors.initials: J
authors.lastname: Braeckman