title: Analyses of the role of the glucocorticoid receptor gene polymorphism (rs41423247) as a potential moderator in the association between childhood overweight, psychopathology, and clinical outcomes in Eating Disorders patients: A 6 years follow up study.
abstract: Childhood overweight and the SNP rs41423247 of the glucocorticoid receptor gene (GR) were reported to represent predisposing factors for Eating Disorders (EDs). The distribution of the polymorphism was evaluated in 202 EDs patients, and in 116 healthy subjects. The Structured Clinical Interview for the DSM-IV and self-reported questionnaires were administered at the admission to the clinic and at 3 time points (end of a cognitive behavioral therapy, 3 and 6 years follow up). G-allele was associated with childhood overweight, depressive disorder comorbidity, and diagnostic instability. G-allele carriers reporting childhood overweight showed greater frequency of subjective binge eating and emotional eating.
authors.affiliation: Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Italy; Sexual Medicine and Andrology Unit, Department of Experimental, Clinical and Biomedical Sciences, University of Florence, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Castellini
authors.affiliation: Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Lelli
authors.affiliation: Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Tedde
authors.affiliation: Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Italy.
authors.forename: Irene
authors.initials: I
authors.lastname: Piaceri
authors.affiliation: Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Bagnoli
authors.affiliation: Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Italy.
authors.forename: Ersilia
authors.initials: E
authors.lastname: Lucenteforte
authors.affiliation: Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Italy.
authors.forename: Sandro
authors.initials: S
authors.lastname: Sorbi
authors.affiliation: Department of Psychiatry, University of Naples SUN, Naples, Italy.
authors.forename: Alessio Maria
authors.initials: AM
authors.lastname: Monteleone
authors.affiliation: Vermont Center for Children, Youth, and Families, University of Vermont, Burlington, VT, United States; Erasmus University, Sophia Children's Hospital, Rotterdam, The Netherlands; Department of Child Psychiatry, Washington University, St. Louis, MO, United States.
authors.forename: James J
authors.initials: JJ
authors.lastname: Hudziak
authors.affiliation: Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Italy.
authors.forename: Benedetta
authors.initials: B
authors.lastname: Nacmias
authors.affiliation: Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Italy. Electronic address: valdo.ricca@unifi.it.
authors.forename: Valdo
authors.initials: V
authors.lastname: Ricca
mesh_terms: D000328:Adult; D015928:Cognitive Behavioral Therapy; D039721:Diagnostic and Statistical Manual of Mental Disorders; D004435:Eating / Q000235:genetics* / Q000523:psychology; D004644:Emotions; D001068:Feeding and Eating Disorders / Q000235:genetics* / Q000523:psychology / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000235:genetics* / Q000523:psychology / Q000628:therapy; D050177:Overweight / Q000235:genetics* / Q000523:psychology; D020641:Polymorphism, Single Nucleotide; D011965:Receptors, Glucocorticoid / Q000235:genetics*; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D011965:Receptors, Glucocorticoid
keywords: BclI receptor gene polymorphism; Childhood overweight; Eating Disorders; rs41423247