title: OsREM4.1 Interacts with OsSERK1 to Coordinate the Interlinking between Abscisic Acid and Brassinosteroid Signaling in Rice.
abstract: Crosstalk among phytohormones is crucial for balancing plant growth and adjustment to various environments. Abscisic acid (ABA) and brassinosteroids (BRs) exhibit antagonistic interactions during many plant development processes, but little is known about the molecular mechanism mediating those interactions. Here, we identified a rice (Oryza sativa) remorin gene, OsREM4.1, whose expression is upregulated by ABA through the transcriptional activator OsbZIP23. OsREM4.1, in return, negatively regulates BR signaling output. We discovered that OsREM4.1 interacts with OsSERK1 to inhibit its interaction with rice BR receptor OsBRI1. Moreover, OsBRI1 could phosphorylate OsREM4.1 to reduce the binding affinity of OsREM4.1 to OsSERK1. These results demonstrate that OsREM4.1 is transcriptionally regulated by ABA and functions as an OsBRI1 substrate and OsSERK1-interacting protein to inhibit the formation and subsequent activation of the OsBRI1-OsSERK1 receptor complex. Our findings provide insight into the mechanism by which the antagonistic interactions between ABA and BRs are coordinated in rice.
authors.affiliation: National Key Laboratory of Plant Molecular Genetics and CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, 300 Fenglin Road, Shanghai 200032, China.
authors.forename: Jinshan
authors.initials: J
authors.lastname: Gui
authors.affiliation: National Key Laboratory of Plant Molecular Genetics and CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, 300 Fenglin Road, Shanghai 200032, China; Shanghai Institute for Biological Sciences, University of the Chinese Academy of Sciences, Shanghai 200032, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Zheng
authors.affiliation: National Key Laboratory of Plant Molecular Genetics and CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, 300 Fenglin Road, Shanghai 200032, China; Shanghai Institute for Biological Sciences, University of the Chinese Academy of Sciences, Shanghai 200032, China.
authors.forename: Chang
authors.initials: C
authors.lastname: Liu
authors.affiliation: National Key Laboratory of Plant Molecular Genetics and CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, 300 Fenglin Road, Shanghai 200032, China.
authors.forename: Junhui
authors.initials: J
authors.lastname: Shen
authors.affiliation: Shanghai Center for Plant Stress Biology, Chinese Academy of Sciences, No. 3888 Chenhua Road, Shanghai 201602, China; Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109-1048, USA.
authors.forename: Jianming
authors.initials: J
authors.lastname: Li
authors.affiliation: National Key Laboratory of Plant Molecular Genetics and CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, 300 Fenglin Road, Shanghai 200032, China. Electronic address: lgli@sibs.ac.cn.
authors.forename: Laigeng
authors.initials: L
authors.lastname: Li
mesh_terms: D000040:Abscisic Acid / Q000494:pharmacology*; D060406:Brassinosteroids / Q000494:pharmacology*; D018506:Gene Expression Regulation, Plant / Q000187:drug effects; D012275:Oryza / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D063245:Plant Development / Q000187:drug effects*; D010937:Plant Growth Regulators / Q000494:pharmacology; D018515:Plant Leaves / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D030821:Plants, Genetically Modified / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D060406:Brassinosteroids; D010937:Plant Growth Regulators; D000040:Abscisic Acid