title: Co-morbidity in psoriasis: mechanisms and implications for treatment.
abstract: Psoriasis is a common, chronic, immune-mediated inflammatory disorder. The disease is associated with several co-morbidities including cardiovascular disease, metabolic syndrome, and psychiatric disorders. It is important to identify and treat these co-morbidities because they have a strongly negative effect on the overall health of patients with psoriasis. Unfortunately, these co-morbidities are often overlooked and/or left untreated. Therefore, the aim of this review is to discuss the mechanisms of how co-morbidities are associated with psoriasis as well as implications for the clinic to be able to recognize such co-morbidities. Areas covered: This is a review of studies investigating and discussing co-morbidities of psoriasis and screening. Literature was retrieved by searching on the PubMed database using individual and combined search terms related to relevant co-morbidities. Expert commentary: Effective management of psoriasis involves targeting of both psoriasis and co-morbidities.
authors.affiliation: a Department of Dermato-Allergology, Herlev and Gentofte Hospital , University of Copenhagen , Hellerup , Denmark.
authors.forename: Ann Sophie
authors.initials: AS
authors.lastname: Lønnberg
authors.affiliation: a Department of Dermato-Allergology, Herlev and Gentofte Hospital , University of Copenhagen , Hellerup , Denmark.
authors.forename: Lone
authors.initials: L
authors.lastname: Skov
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D015897:Comorbidity; D006801:Humans; D008403:Mass Screening; D001523:Mental Disorders / Q000453:epidemiology*; D024821:Metabolic Syndrome / Q000453:epidemiology*; D011565:Psoriasis / Q000453:epidemiology*
keywords: Psoriasis; cardiovascular disease; co-morbidities; comorbidity; genetics; inflammatory diseases; metabolic syndrome; risk factors; treatment