title: Stereotactic Body Radiation Therapy for Stage I Non-Small Cell Lung Cancer: A Retrospective, Single-Center Study of 55 Patients.
abstract: Purpose/Objective(s): Stereotactic body radiation therapy (SBRT) is an effective treatment for patients with early-stage non-small cell lung cancer (NSCLC) who are not surgical candidates or who refuse surgical management. In this study, we report on our clinical outcomes and toxicity in the treatment of early-stage NSCLC with SBRT.
  
  
  METHODS
  Fifty-five patients with 59 T1-2N0M0 NSCLC lesions were treated at our institution between December 2009 and August 2014. The majority of the patients [38 (69%)] were treated with 50 Gy in 5 fractions, 7 patients (13%) with 48 Gy in 4 fractions, 8 patients (14%) with 60 Gy in 3 fractions, 1 patient (2%) with 62.5 Gy in 10 fractions, and 1 patient (2%) with 54 Gy in 3 fractions. Tumor response was evaluated using RECIST 1.1, and toxicity was graded using the CTCAE (Common Terminology Criteria for Adverse Events) version 3.0. The primary endpoints of this retrospective review included rates of overall survival, disease-free and progression-free survival, local failure, regional failure, and distant failure. A secondary endpoint included radiation-related toxicities.
  
  
  RESULTS
  The median follow-up was 23.8 months (range 1.1-57.6). The 3-year local control, progression-free survival, and overall survival rates were 91, 55, and 71%, respectively. The median age at diagnosis was 67.9 years (range 51.4-87.1). There were a total of 54 T1N0 tumors (92%) and 5 T2N0 lesions (8%). Adenocarcinoma was the most common pathology, comprising 54% of the lesions. A total of 16 of the patients (29%) failed. Among these, 5 local (9%), 14 regional (25%), and 4 distant failures (7%) were observed. On follow-up, one patient had grade 2 and another had grade 5 pneumonitis. Three patients experienced grade 2 chest wall tenderness. Two patients had grade 1 rib fractures, one of which could not be discerned from radiation-induced toxicity versus a traumatic fall.
  
  
  CONCLUSIONS
  The University of Mississippi Medical Center SBRT experience has shown that SBRT provides satisfactory local control and overall survival rates with minimal toxicity in early-stage NSCLC patients.
authors.affiliation: Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, Miss., USA.
authors.forename: Rahul P
authors.initials: RP
authors.lastname: Bhandari
authors.forename: Jason D
authors.initials: JD
authors.lastname: Stanford
authors.forename: Satya
authors.initials: S
authors.lastname: Packianathan
authors.forename: William N
authors.initials: WN
authors.lastname: Duggar
authors.forename: Madhava R
authors.initials: MR
authors.lastname: Kanakamedala
authors.forename: Xu
authors.initials: X
authors.lastname: Zhang
authors.forename: Shankar P
authors.initials: SP
authors.lastname: Giri
authors.forename: Pullatikurthi P
authors.initials: PP
authors.lastname: Kumar
authors.forename: Leslie M
authors.initials: LM
authors.lastname: Harrell
authors.forename: Sophy H
authors.initials: SH
authors.lastname: Mangana
authors.forename: Chunli
authors.initials: C
authors.lastname: Yang
authors.forename: Srinivasan
authors.initials: S
authors.lastname: Vijayakumar
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000532:radiotherapy* / Q000556:secondary*; D018572:Disease-Free Survival; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology* / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D017564:Radiation Pneumonitis / Q000209:etiology; D016634:Radiosurgery / Q000009:adverse effects; D011880:Radiotherapy Planning, Computer-Assisted; D066066:Response Evaluation Criteria in Solid Tumors; D012189:Retrospective Studies; D012253:Rib Fractures / Q000209:etiology; D015996:Survival Rate