title: Ruthenium(ii) complexes with dppz: from molecular photoswitch to biological applications.
abstract: The DNA photoswitch [Ru(bpy)2dppz](2+) (bpy = 2,2'-bipyridine, dppz = dipyrido[3,2-a:2',3'-c]phenazine) has attracted much attention and become a powerful tool for studying the interaction of metal polypyridyl complexes with DNA. A large number of Ru-dppz complexes have been designed for a wide range of uses in many fields. In this perspective, we first introduce the latest results of Ru-dppz complexes that bind with DNA. The mechanisms of the light-switch effect and the structural modifications of Ru-dppz systems are also briefly introduced. We also review the recent advances in biological applications of the Ru-dppz system in DNA binders, cellular imaging, anticancer drugs, protein aggregation detection and chemosensors.
authors.affiliation: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, 510275, P. R. China. ceschh@mail.sysu.edu.cn.
authors.forename: Guanying
authors.initials: G
authors.lastname: Li
authors.forename: Lingli
authors.initials: L
authors.lastname: Sun
authors.forename: Liangnian
authors.initials: L
authors.lastname: Ji
authors.forename: Hui
authors.initials: H
authors.lastname: Chao
mesh_terms: D016229:Amyloid beta-Peptides / Q000737:chemistry; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D001665:Binding Sites; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000737:chemistry*; D004563:Electrochemistry; D006801:Humans; D007364:Intercalating Agents / Q000737:chemistry*; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D061848:Optical Imaging; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology; D010619:Phenazines / Q000737:chemistry* / Q000494:pharmacology; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000494:pharmacology; D011485:Protein Binding
chemical_list: D016229:Amyloid beta-Peptides; D000970:Antineoplastic Agents; D007364:Intercalating Agents; D008024:Ligands; D009942:Organometallic Compounds; D010619:Phenazines; D017319:Photosensitizing Agents; C077849:bis(2,2'-bipyridyl)(dipyrido(3,2-alpha-2',3'-c)phenazine)ruthenium (II); D004247:DNA