title: C-C motif chemokine ligand 5 (CCL5) levels in gastric cancer patient sera predict occult peritoneal metastasis and a poorer prognosis.
abstract: Gastric cancer is one of the most common cancers and the third leading cause of cancer death worldwide. A number of chemokines and cytokines play important roles in the progress of gastric cancer. The roles of C-C motif chemokine ligand 5 (CCL5) in gastric cancer remain unclear. Here, we retrospectively report an analysis of 105 patients with gastric cancer. Increased levels of CCL5 in circulation were correlated with more advanced T and N stages, poorly- or un-differentiated histological types, peritoneal metastasis, higher rates of residual tumor, and shorter survivals. Patients in the CCL5 High Group had stronger CCL5 immunohistochemistry (IHC) staining in tumor beds. Circulating CCL5 concentrations before surgery are a good biomarker for occult peritoneal metastasis. Elevated levels of serum CCL5, along with strong IHC CCL5 staining and poorly- or un-differentiated cancer are predictors for poorer outcomes. In conclusion, increased serum levels of CCL5 can be used to predict peritoneal dissemination and a poorer prognosis.
authors.affiliation: The Department of Gastrointestinal Surgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang Province, China.
authors.forename: Tie
authors.initials: T
authors.lastname: Wang
authors.affiliation: The Department of Gastrointestinal Surgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang Province, China.
authors.forename: Yuzhe
authors.initials: Y
authors.lastname: Wei
authors.affiliation: The Department of Medical Education, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
authors.forename: Lining
authors.initials: L
authors.lastname: Tian
authors.affiliation: The Department of Gastrointestinal Surgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang Province, China.
authors.forename: Hongjiang
authors.initials: H
authors.lastname: Song
authors.affiliation: The Department of Gastrointestinal Surgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang Province, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Ma
authors.affiliation: The Department of Gastrointestinal Surgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang Province, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Yao
authors.affiliation: The Department of Pathology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang Province, China.
authors.forename: Meiyan
authors.initials: M
authors.lastname: Feng
authors.affiliation: The Department of Pathology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang Province, China.
authors.forename: Yanying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: The Department of General Surgery, The Forth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
authors.forename: Meizhuo
authors.initials: M
authors.lastname: Gao
authors.affiliation: The Department of Gastrointestinal Surgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang Province, China. Electronic address: medwang@163.com.
authors.forename: Yingwei
authors.initials: Y
authors.lastname: Xue
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D018946:Chemokine CCL5 / Q000097:blood*; D002681:China; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010534:Peritoneal Neoplasms / Q000401:mortality / Q000556:secondary*; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000097:blood / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; D018946:Chemokine CCL5
keywords: CCL5; Gastric cancer; Peritoneal metastasis; Prognosis