title: Assessment of Cardiac Morphological and Functional Changes in Mouse Model of Transverse Aortic Constriction by Echocardiographic Imaging.
abstract: Transverse aortic constriction (TAC) in mice has been used as a valuable model to study mechanisms of cardiac hypertrophy and heart failure(1). A reliable noninvasive method is essential to assess real-time cardiac morphological and functional changes in animal models of heart disease. Transthoracic echocardiography represents an important tool for noninvasive assessment of cardiac structure and function(2). Here we used a high-resolution ultrasound imaging system to monitor myocardial remodeling and heart failure progression over time in a mouse model of TAC. B-mode, M-mode, and Doppler imaging were used to precisely assess cardiac hypertrophy, ventricular dilatation, and functional deterioration in mice following TAC. Color and pulse wave (PW) Doppler imaging was used to noninvasively measure pressure gradient across the aortic constriction created by TAC and to assess transmitral blood flow in mice. Thus transthoracic echocardiographic imaging provides comprehensive noninvasive measurements of cardiac dimensions and function in mouse models of heart disease.
authors.affiliation: Department of Physiology and Biophysics, University of Washington.
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Physiology and Biophysics, University of Washington.
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Guo
authors.affiliation: Department of Physiology and Biophysics, University of Washington.
authors.forename: Yi
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Physiology and Biophysics, University of Washington.
authors.forename: Haifeng
authors.initials: H
authors.lastname: Yin
authors.affiliation: Department of Physiology and Biophysics, University of Washington.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Physiology and Biophysics, University of Washington.
authors.forename: Jessica
authors.initials: J
authors.lastname: Doan
authors.affiliation: Department of Physiology and Biophysics, University of Washington; qcliu@uw.edu.
authors.forename: Qinghang
authors.initials: Q
authors.lastname: Liu
mesh_terms: D000818:Animals; D003250:Constriction; D004195:Disease Models, Animal; D004452:Echocardiography; D006321:Heart; D006333:Heart Failure; D051379:Mice; D008810:Mice, Inbred C57BL