title: Evaluation of the Ganglion Cell Complex and Retinal Nerve Fiber Layer in Low, Moderate, and High Myopia: A Study by RTVue Spectral Domain Optical Coherence Tomography.
abstract: OBJECTIVE
  To assess the effect of low, moderate, and high myopia on the thickness of the retinal nerve fiber layer (RNFL) and Ganglion cell complex (GCC) measured by Spectral Domain Optical Coherence Tomography (SD-OCT) in non-glaucomatous subjects.
  
  
  METHODS
  The subjects were divided into three groups: low (n = 81, 35.6%), moderate (n = 79, 34.8%), and highly myopic eyes (n = 67, 29.5%). The RNFL thickness profile, including the average, superior, nasal, inferior, and temporal quadrant and each of the eight directional thicknesses, was measured. GCC parameters, including the average, superior, and inferior values, the focal loss volume (FLV), and the global loss volume (GLV), were measured. The correlation between the OCT measurements and the axial length was evaluated.
  
  
  RESULTS
  The average, superior, inferior, and nasal RNFL thicknesses of low and moderate myopic eyes were found to be significantly higher than those of highly myopic eyes. The temporal RNFL thicknesses were not different among the three groups. The average, superior, and inferior ganglion cell complex values of low and moderate myopic eyes were significantly higher than those of highly myopic eyes. The FLV and GLV of low and moderate myopic eyes were significantly higher than those of highly myopic eyes (p = 0.001 for all). In the moderate and high myopia groups, the average RNFL thickness and GCC thickness were both negatively correlated with the axial length.
  
  
  CONCLUSIONS
  Highly myopic subjects tend to have thinner RNFL and GCC thicknesses than subjects with low and moderate myopia.
authors.affiliation: a Umraniye Training and Research Hospital , Department of Ophthalmology , Istanbul , Turkey.
authors.forename: Betul Ilkay
authors.initials: BI
authors.lastname: Sezgin Akcay
authors.affiliation: a Umraniye Training and Research Hospital , Department of Ophthalmology , Istanbul , Turkey.
authors.forename: Betul Onal
authors.initials: BO
authors.lastname: Gunay
authors.affiliation: a Umraniye Training and Research Hospital , Department of Ophthalmology , Istanbul , Turkey.
authors.forename: Esra
authors.initials: E
authors.lastname: Kardes
authors.affiliation: a Umraniye Training and Research Hospital , Department of Ophthalmology , Istanbul , Turkey.
authors.forename: Cihan
authors.initials: C
authors.lastname: Unlu
authors.affiliation: a Umraniye Training and Research Hospital , Department of Ophthalmology , Istanbul , Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Ergin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D019540:Area Under Curve; D058452:Axial Length, Eye / Q000473:pathology; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000000981:diagnostic imaging / Q000473:pathology*; D047728:Myopia, Degenerative / Q000473:pathology; D009412:Nerve Fibers / Q000502:physiology*; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000379:methods*; D055815:Young Adult
keywords: FLV; GLV; ganglion cell complex; myopia; retinal nerve fiber layer