title: Modeling the Epigenetic Chain Reaction Downstream of DNMT3A(R882H).
abstract: In this issue of Cancer Cell, Lu et al. use a mouse model of DNMT3A(R882H)/NRAS(G12D) acute myeloid leukemia to define a cascade of chromatin changes that emanate from DNMT3A-bound enhancers to initiate disease. The authors also reveal a chemical strategy to interrupt this process.
authors.affiliation: Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.
authors.forename: Tim D D
authors.initials: TDD
authors.lastname: Somerville
authors.affiliation: Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA. Electronic address: vakoc@cshl.edu.
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Vakoc
mesh_terms: D000818:Animals; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000235:genetics*; D057890:Epigenomics; D015470:Leukemia, Myeloid, Acute; D009154:Mutation
chemical_list: D004248:DNA (Cytosine-5-)-Methyltransferases