title: Platelet function testing as a biomarker for efficacy of antiplatelet drugs.
abstract: Despite the overwhelming evidence in support of the efficacy of dual antiplatelet therapy with aspirin and clopidogrel, it is also obvious that not all patients benefit from these drugs to the same extent. This interindividual variability in platelet responses may underlie clinical differences in drug efficacy, with potential for optimization of antiplatelet therapy to prevent ischemic events without excessively increasing bleeding risk. This review presents the current evidence regarding platelet function testing for monitoring of antiplatelet therapy, with emphasis on the prognostic value of platelet function testing to predict ischemic and bleeding events. The potential of platelet function testing to provide personalized antiplatelet therapy is also discussed, with an outlook toward the future of platelet function testing in high-risk individuals.
authors.affiliation: Faculté de Pharmacie, Université de Montréal, C.P. 6128, Succ. Centre-ville, Montréal, QC, H3C 3J7, Canada.|Research Center, Montreal Heart Institute, 5000 rue Bélanger, Montréal, QC, H1T 1C8, Canada.
authors.forename: Marie
authors.initials: M
authors.lastname: Lordkipanidzé
authors.affiliation: Division of Cardiology, University of Ottawa Heart Institute, 40 Ruskin St, Ottawa, ON, K1Y 4W7, Canada.
authors.forename: Derek
authors.initials: D
authors.lastname: So
authors.affiliation: Faculté de Médecine, Université de Montréal, C.P. 6128, succ. Centre-ville, Montréal, QC, H3C 3J7, Canada.|Department of Medicine, Montreal Heart Institute, 5000 rue Bélanger, Montréal, QC, H1T 1C8, Canada.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Tanguay
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D001792:Blood Platelets / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000473:pathology; D000077144:Clopidogrel; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D010979:Platelet Function Tests; D057285:Precision Medicine; D058921:Purinergic P2Y Receptor Antagonists / Q000627:therapeutic use; D013988:Ticlopidine / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D015415:Biomarkers; D010975:Platelet Aggregation Inhibitors; D058921:Purinergic P2Y Receptor Antagonists; D000077144:Clopidogrel; D013988:Ticlopidine
keywords: P2Y12 receptor antagonists; antiplatelet therapy; clopidogrel; individualized therapy; major adverse cardiovascular events; platelet function testing; prasugrel; prediction; ticagrelor