title: A Large Capacity Cationic Metal-Organic Framework Nanocarrier for Physiological pH Responsive Drug Delivery.
abstract: A nanoscale cationic porous drug carrier ZJU-101 (ZJU = Zhejiang University), synthesized by the solvothermal method to get the crystal size of ∼300 nm, was used to load diclofenac sodium, an anionic drug. This positively charged host materials showed a large loading capacity of diclofenac sodium (∼0.546 g/g) through ion exchange and penetration procedures. The drug delivery in the inflamed tissues (pH = 5.4) exhibited a more effective release in comparison with that in the normal tissues (pH = 7.4), demonstrating a physiological pH responsive drug release. This discriminating drug release process was controlled by anion exchange between anions in phosphate buttered saline (PBS) and coordinated/free diclofenac anions.
authors.affiliation: State Key Laboratory of Silicon Material, Cyrus Tang Center for Sensor Material and Applications, School of Materials Science and Engineering, Zhejiang University , Hangzhou 310027, P.R. China.
authors.forename: Yanyu
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Pharmacology, School of Medicine, Hangzhou Normal University , Hangzhou 310036, P.R. China.
authors.forename: Quan
authors.initials: Q
authors.lastname: Hu
authors.affiliation: State Key Laboratory of Silicon Material, Cyrus Tang Center for Sensor Material and Applications, School of Materials Science and Engineering, Zhejiang University , Hangzhou 310027, P.R. China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Silicon Material, Cyrus Tang Center for Sensor Material and Applications, School of Materials Science and Engineering, Zhejiang University , Hangzhou 310027, P.R. China.
authors.forename: Ke
authors.initials: K
authors.lastname: Jiang
authors.affiliation: State Key Laboratory of Silicon Material, Cyrus Tang Center for Sensor Material and Applications, School of Materials Science and Engineering, Zhejiang University , Hangzhou 310027, P.R. China.
authors.forename: Wenxin
authors.initials: W
authors.lastname: Lin
authors.affiliation: State Key Laboratory of Silicon Material, Cyrus Tang Center for Sensor Material and Applications, School of Materials Science and Engineering, Zhejiang University , Hangzhou 310027, P.R. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Silicon Material, Cyrus Tang Center for Sensor Material and Applications, School of Materials Science and Engineering, Zhejiang University , Hangzhou 310027, P.R. China.
authors.forename: Yuanjing
authors.initials: Y
authors.lastname: Cui
authors.affiliation: State Key Laboratory of Silicon Material, Cyrus Tang Center for Sensor Material and Applications, School of Materials Science and Engineering, Zhejiang University , Hangzhou 310027, P.R. China.
authors.forename: Guodong
authors.initials: G
authors.lastname: Qian
mesh_terms: D000818:Animals; D002412:Cations / Q000737:chemistry; D045744:Cell Line, Tumor; D004008:Diclofenac / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D065546:Drug Liberation; D006863:Hydrogen-Ion Concentration; D018613:Microscopy, Confocal; D051381:Rats
chemical_list: D002412:Cations; D004337:Drug Carriers; D004008:Diclofenac
keywords: cationic MOF; drug loading capacity; nanoscale carrier; physiological pH responsive release