title: Id1 knockdown induces the apoptosis and inhibits the proliferation and invasion of ovarian cancer cells.
abstract: To explore the role of Id1 in ovarian cancer cell proliferation, invasion and apoptosis.
  
  
  
  Lentivirus-based shRNA vectors were constructed to knockdown Id1 expression in SKOV3 ovarian cancer cells. The proliferation, invasion ability and apoptosis of SKOV3 cells were evaluated by CCK-8 assay, transwell assay and flow cytometry, respectively.
  
  
  
  Compared to control cells, cell proliferation and invasion were significantly inhibited in SKOV3 cells depleted of Id1, while apoptosis was significantly increased in SKOV3 cells depleted of Id1.
  
  
  
  Id1 functions to promote ovarian cancer cell proliferation and invasion, and Id1 is a promising therapeutic target for ovarian cancer.
authors.affiliation: Department of Gynecology, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, China. sjystudent@126.com.
authors.forename: W-Z
authors.initials: WZ
authors.lastname: Sun
authors.forename: M-H
authors.initials: MH
authors.lastname: Li
authors.forename: M
authors.initials: M
authors.lastname: Chu
authors.forename: L-L
authors.initials: LL
authors.lastname: Wei
authors.forename: M-Y
authors.initials: MY
authors.lastname: Bi
authors.forename: Y
authors.initials: Y
authors.lastname: He
authors.forename: L-B
authors.initials: LB
authors.lastname: Yu
mesh_terms: D017209:Apoptosis; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000235:genetics; D034741:RNA, Small Interfering / Q000235:genetics
chemical_list: D034741:RNA, Small Interfering