title: Effects of Elevated In Ovo Selenium Exposure on Late Stage Development of Xenopus laevis Tadpoles.
abstract: The effects of elevated in ovo selenium (Se) exposure on late stage larval Xenopus laevis development were investigated. Adult females were fed diets augmented with selenomethionine for 68 days and bred with untreated males to obtain embryos with measured concentrations of 1.6 (control), 10.8, 28.1 and 81.7 μg Se/g dry mass. Embryos were reared under uncontaminated conditions until 50 % of individuals within an aquarium had completed metamorphosis. The highest in ovo Se exposure group exhibited greater froglet body mass and snout to vent length while having a higher proportion of tadpoles at earlier stages of development. No differences were detected among treatment groups for mortality or metamorphic timing during the rearing period. This research suggests that in ovo Se exposure has minimal effect on the survival and development of late stage larval X. laevis in a controlled laboratory environment with adequate food availability.
authors.affiliation: Toxicology Graduate Program, University of Saskatchewan, Saskatoon, SK, S7N 5B3, Canada.
authors.forename: Anita J
authors.initials: AJ
authors.lastname: Massé
authors.affiliation: Stantec Consulting Ltd., Burnaby, BC, V5H 0C6, Canada.
authors.forename: Jorgelina R
authors.initials: JR
authors.lastname: Muscatello
authors.affiliation: Toxicology Centre, University of Saskatchewan, Saskatoon, SK, S7N 5B3, Canada. david.janz@usask.ca.|Department of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, SK, S7N 5B4, Canada. david.janz@usask.ca.
authors.forename: David M
authors.initials: DM
authors.lastname: Janz
mesh_terms: D000818:Animals; D004032:Diet; D005260:Female; D007814:Larva / Q000187:drug effects; D008297:Male; D008675:Metamorphosis, Biological / Q000187:drug effects*; D012643:Selenium / Q000494:pharmacology*; D012645:Selenomethionine / Q000494:pharmacology*; D014982:Xenopus laevis
chemical_list: D012645:Selenomethionine; D012643:Selenium
keywords: Amphibian; Development; Maternal; Selenium; Selenomethionine; Xenopus