title: DNA repair gene polymorphisms in non-small-cell lung cancer patients treated with first-line platinum-containing chemotherapy.
abstract: OBJECTIVE
  Single nucleotide polymorphisms (SNPs) in the DNA repair genes are believed to contribute to the clinical outcome of patients receiving platinum-based chemotherapy. We investigated the impact of 2 SNPs of excision repair cross-complementation group 1 and 2 of xeroderma pigmentosum complementation group G on the outcome in patients with non-small-cell lung cancer (NSCLC) treated with platinum-based chemotherapy.
  
  
  METHODS
  Between October 2007 and March 2012, we collected 374 blood samples from consecutive patients registered in the TAILOR trial. Four SNPs (rs11615, rs3212986, rs17655, rs1047768) were genotyped using real-time polymerase chain reaction.
  
  
  RESULTS
  The rs11615 polymorphism was associated with histotype (p = 0.0123). No other correlations were found with clinical variables or with EGFR or KRAS mutational status. None of the SNPs had any impact on overall survival or progression-free survival.
  
  
  CONCLUSIONS
  The findings suggest that the investigated SNPs do not make any significant contribution to the outcome of NSCLC.
authors.affiliation: Clinical Research Methodology Laboratory, Oncology Department, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milan - Italy.
authors.forename: Eliana
authors.initials: E
authors.lastname: Rulli
authors.affiliation: Molecular Genetics Unit, Oncology Department, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milan - Italy.
authors.forename: Mirko
authors.initials: M
authors.lastname: Marabese
authors.affiliation: Oncology Department, Ospedale Fatebenefratelli e Oftalmico, Milan - Italy.
authors.forename: Sheila
authors.initials: S
authors.lastname: Piva
authors.affiliation: Oncology Department, Ospedale Papa Giovanni XXIII, Bergamo - Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Bonomi
authors.affiliation: Molecular Genetics Unit, Oncology Department, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milan - Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Caiola
authors.affiliation: Thoracic Unit, Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan - Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Ganzinelli
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D014408:Biomarkers, Tumor; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000235:genetics* / Q000401:mortality; D004260:DNA Repair / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D018773:Genes, erbB-1; D011905:Genes, ras; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000235:genetics* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009367:Neoplasm Staging; D010984:Platinum / Q000008:administration & dosage; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D012307:Risk Factors
chemical_list: D014408:Biomarkers, Tumor; D010984:Platinum