title: Chiral N-1-adamantyl-N-trans-cinnamylaniline type ligands: synthesis and application to palladium-catalyzed asymmetric allylic alkylation of indoles.
abstract: Such chiral phosphine-internal olefin hybrid type ligands as N-1-adamantyl-N-cinnamylaniline derivatives 1 with C(aryl)-N(amine) bond axial chirality were synthesized and utilized for the palladium-catalyzed asymmetric allylic alkylation of indoles to afford the desired products in high enantioselectivities (up to 98% ee).
authors.affiliation: Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, Chiba University, 1-33, Yayoi-cho, Inage-ku, Chiba 263-8522, Japan. tmino@faculty.chiba-u.jp.
authors.forename: Takashi
authors.initials: T
authors.lastname: Mino
authors.forename: Kenji
authors.initials: K
authors.lastname: Nishikawa
authors.forename: Moeko
authors.initials: M
authors.lastname: Asano
authors.forename: Yamato
authors.initials: Y
authors.lastname: Shima
authors.forename: Toshibumi
authors.initials: T
authors.lastname: Ebisawa
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Masami
authors.initials: M
authors.lastname: Sakamoto