title: Serum adenosine deaminase, catalase, and carbonic anhydrase activities in patients with renal cell carcinoma.
abstract: OBJECTIVE
  To determine whether serum levels of adenosine deaminase (AD), catalase (CAT), and carbonic anhydrase (CA) enzymes may be useful biomarkers in the diagnosis of renal tumors and may lead to early diagnosis of renal tumors.
  
  
  METHODS
  The study included 33 patients with renal cell carcinoma (RCC) and 31 healthy controls. The activity of serum AD, CA, and CAT was determined and analyzed using the Giusti spectrophotometric method, H2O2substrate, and C02hydration, respectively.
  
  
  RESULTS
  Serum AD and CA activity were significantly higher in patients with RCC than in controls. However, serum CAT activity was significantly lower in patients with RCC than in controls.
  
  
  CONCLUSIONS
  These markers might be potentially important as an additional biochemical tool for diagnosing RCC. We believe multidisciplinary studies are needed to plan patients' preoperative and postoperative treatment and to create follow-up protocols.
authors.affiliation: a Department of Urology, Faculty of Medicine , Fırat Üniversity , Elazığ , Turkey.
authors.forename: Necip
authors.identifier: http://orcid.org/0000-0002-5494-0984
authors.initials: N
authors.lastname: Pirinççi
authors.affiliation: b Ministry of Health, Bismil State Hospital, Clinic of Urology , Diyarbakır , Turkey.
authors.forename: Tacettin Yekta
authors.initials: TY
authors.lastname: Kaya
authors.affiliation: c Department of Urology, Faculty of Medicine , Yüzüncü Yıl Üniversity , Van , Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kaba
authors.affiliation: a Department of Urology, Faculty of Medicine , Fırat Üniversity , Elazığ , Turkey.
authors.forename: Tunç
authors.initials: T
authors.lastname: Ozan
authors.affiliation: c Department of Urology, Faculty of Medicine , Yüzüncü Yıl Üniversity , Van , Turkey.
authors.forename: İlhan
authors.initials: İ
authors.lastname: Geçit
authors.affiliation: c Department of Urology, Faculty of Medicine , Yüzüncü Yıl Üniversity , Van , Turkey.
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Özveren
authors.affiliation: c Department of Urology, Faculty of Medicine , Yüzüncü Yıl Üniversity , Van , Turkey.
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Eren
authors.affiliation: d Department of Urology, Faculty of Medicine , Selcuk Üniversity , Konya , Turkey.
authors.forename: Kadir
authors.identifier: http://orcid.org/0000-0002-9783-4831
authors.initials: K
authors.lastname: Ceylan
mesh_terms: D000243:Adenosine Deaminase / Q000378:metabolism*; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002256:Carbonic Anhydrases / Q000378:metabolism*; D002292:Carcinoma, Renal Cell / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
chemical_list: D014408:Biomarkers, Tumor; D002374:Catalase; D000243:Adenosine Deaminase; D002256:Carbonic Anhydrases
keywords: Adenosine deaminase; Antioxidant enzymes; Carbonic anhydrase; Catalase; Renal cell carcinoma