title: Recipient-derived EBV-positive Monomorphic Plasmacytoma Type Posttransplant Lymphoproliferative Disorder After Allogeneic Stem Cell Transplant for Severe Aplastic Anemia: A Case Report.
abstract: Monomorphic plasmacytoma-type posttransplant lymphoproliferative disorder (PTLD) has not been reported after pediatric hematopoietic stem cell transplantation. We present a child with hepatitis-associated severe aplastic anemia who underwent an unrelated allogeneic hematopoietic stem cell transplantation and subsequently developed graft failure and an Epstein-Barr virus-positive monomorphic plasmacytoma-type PTLD of recipient origin. Despite broad-spectrum antimicrobials, weaning immunosuppression, rituximab administration, and a stem cell boost she died from complications of PTLD and a fungal pulmonary infection on day +78.
authors.affiliation: *Aflac Cancer and Blood Disorders Center ‡Department of Pathology, Children's Healthcare of Atlanta †Department of Pediatrics, Emory University School of Medicine, Atlanta, GA §Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY.
authors.forename: Marcus A
authors.initials: MA
authors.lastname: Carden
authors.forename: Shelley
authors.initials: S
authors.lastname: Caltharp
authors.forename: Marianne E
authors.initials: ME
authors.lastname: Yee
authors.forename: Ann E
authors.initials: AE
authors.lastname: Haight
authors.forename: Lars F
authors.initials: LF
authors.lastname: Westblade
authors.forename: Sunita
authors.initials: S
authors.lastname: Park
mesh_terms: D000741:Anemia, Aplastic / Q000150:complications / Q000628:therapy*; D002648:Child; D020031:Epstein-Barr Virus Infections; D017809:Fatal Outcome; D005260:Female; D006084:Graft Rejection; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008171:Lung Diseases / Q000209:etiology / Q000382:microbiology; D008232:Lymphoproliferative Disorders / Q000209:etiology* / Q000821:virology; D010954:Plasmacytoma / Q000209:etiology* / Q000821:virology; D014184:Transplantation, Homologous