title: Regulation of inflammation by lipid mediators in oral diseases.
abstract: Lipid mediators (LM) of inflammation are a class of compounds derived from ω-3 and ω-6 fatty acids that play a wide role in modulating inflammatory responses. Some LM possess pro-inflammatory properties, while others possess proresolving characteristics, and the class switch from pro-inflammatory to proresolving is crucial for tissue homeostasis. In this article, we review the major classes of LM, focusing on their biosynthesis and signaling pathways, and their role in systemic and, especially, oral health and disease. We discuss the detection of these LM in various body fluids, focusing on diagnostic and therapeutic applications. We also present data showing gender-related differences in salivary LM levels in healthy controls, leading to a hypothesis on the etiology of inflammatory diseases, particularly Sjögren's syndrome. We conclude by enumerating open areas of research where further investigation of LM is likely to result in therapeutic and diagnostic advances.
authors.affiliation: School of Dentistry, The University of Utah, Salt Lake City, UT, USA.
authors.forename: S
authors.initials: S
authors.lastname: Sommakia
authors.affiliation: School of Dentistry, The University of Utah, Salt Lake City, UT, USA.
authors.forename: O J
authors.initials: OJ
authors.lastname: Baker
mesh_terms: D000818:Animals; D001826:Body Fluids / Q000378:metabolism*; D015777:Eicosanoids / Q000096:biosynthesis / Q000378:metabolism*; D015118:Eicosapentaenoic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D018836:Inflammation Mediators / Q000378:metabolism*; D015289:Leukotrienes / Q000096:biosynthesis / Q000378:metabolism; D044045:Lipoxins; D009059:Mouth Diseases / Q000378:metabolism*; D011453:Prostaglandins / Q000096:biosynthesis / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D015777:Eicosanoids; D018836:Inflammation Mediators; D015289:Leukotrienes; D044045:Lipoxins; D011453:Prostaglandins; D015118:Eicosapentaenoic Acid
keywords: lipoxins; oral cancer; periodontal disease; resolvins; salivary gland