title: Injectable hydrogel-based drug delivery systems for local cancer therapy.
abstract: Common chemotherapy is often associated with adverse effects in normal cells and tissues. As an alternative approach, localized chemotherapy can diminish the toxicity of systemic chemotherapy while providing a sustained release of the chemotherapeutics at the target tumor site. Therefore, injectable biodegradable hydrogels as drug delivery systems for chemotherapeutics have become a matter of importance. Here, we review the application of a variety of injectable hydrogel-based drug delivery systems, including thermosensitive, pH-sensitive, photosensitive, dual-sensitive, as well as active targeting hydrogels, for the treatment of different types of cancer. Generally, injectable hydrogel-based drug delivery systems are found to be more efficacious than the conventional systemic chemotherapy in terms of cancer treatment.
authors.affiliation: Graduate Program of Biomedical Engineering, University of Manitoba, Winnipeg, MB, Canada; Department of Nanotechnology and Tissue Engineering, Stem Cell Technology Research Center, Tehran, Iran. Electronic address: norouzim@myumanitoba.ca.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Norouzi
authors.affiliation: Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Bahareh
authors.initials: B
authors.lastname: Nazari
authors.affiliation: Graduate Program of Biomedical Engineering, University of Manitoba, Winnipeg, MB, Canada; Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, MB, Canada. Electronic address: donald.miller@umanitoba.ca.
authors.forename: Donald W
authors.initials: DW
authors.lastname: Miller
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems; D006801:Humans; D020100:Hydrogels / Q000008:administration & dosage* / Q000737:chemistry / Q000528:radiation effects / Q000627:therapeutic use; D006863:Hydrogen-Ion Concentration; D007267:Injections; D008027:Light; D009369:Neoplasms / Q000188:drug therapy*; D013696:Temperature
chemical_list: D020100:Hydrogels