title: Leukaemic infiltration and cytomegalovirus retinitis in a patient with acute T-cell lymphoblastic leukaemia in complete remission.
abstract: METHODS
  A 43-year-old woman in remission from T- cell acute lymphoblastic leukaemia was referred to our hospital with suspected leukaemic retinitis. The funduscopic examination of her left eye revealed multifocal yellow-white peripheral retinitis and retinal haemorrhage. The patient was treated for cytomegalovirus retinitis after an extended haematological investigation showed no abnormalities. Initial improvement was followed by papillitis in the left eye and motility restriction in the right eye. Magnetic resonance and lumbar puncture confirmed leukaemia relapse. Specific treatment was initiated with complete resolution.
  
  
  CONCLUSIONS
  Ocular involvement may precede haematological leukaemia relapse. Physicians should be alerted when ocular symptoms appear in these cases.
authors.affiliation: Unidad de Retina, Servicio de Oftalmología, Hospital General Universitario de Alicante, Alicante, España. Electronic address: jdsalga@hotmail.com.
authors.forename: J D
authors.initials: JD
authors.lastname: Saldaña Garrido
authors.affiliation: Unidad de Retina, Servicio de Oftalmología, Hospital General Universitario de Alicante, Alicante, España.
authors.forename: M
authors.initials: M
authors.lastname: Martínez Rubio
authors.affiliation: Unidad de Retina, Servicio de Oftalmología, Hospital General Universitario de Alicante, Alicante, España.
authors.forename: R
authors.initials: R
authors.lastname: Carrión Campo
authors.affiliation: Unidad de Retina, Servicio de Oftalmología, Hospital General Universitario de Alicante, Alicante, España.
authors.forename: M A
authors.initials: MA
authors.lastname: Moya Moya
authors.affiliation: Unidad de Retina, Servicio de Oftalmología, Hospital General Universitario de Alicante, Alicante, España.
authors.forename: L
authors.initials: L
authors.lastname: Rico Sergado
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003561:Cytarabine / Q000008:administration & dosage; D017726:Cytomegalovirus Retinitis / Q000209:etiology*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage; D006801:Humans; D015255:Idarubicin / Q000008:administration & dosage; D017254:Leukemic Infiltration / Q000188:drug therapy / Q000532:radiotherapy; D010211:Papilledema / Q000209:etiology; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D012008:Recurrence; D012160:Retina / Q000473:pathology*; D012166:Retinal Hemorrhage / Q000209:etiology; D014740:Vidarabine / Q000008:administration & dosage / Q000031:analogs & derivatives
chemical_list: D003561:Cytarabine; D016179:Granulocyte Colony-Stimulating Factor; D014740:Vidarabine; D015255:Idarubicin
keywords: Acute leukaemia; Afectación ocular; Cytomegalovirus retinitis; Infiltración de nervio óptico; Leucemia aguda; Leukaemic relapse; Leukaemic retinitis; Ocular involvement; Optic nerve infiltration; Papilitis; Papillitis; Recaída leucémica; Retinitis leucémica; Retinitis por citomegalovirus