title: Timed-release system for periosteal expansion osteogenesis using NiTi mesh and absorbable material in the rabbit calvaria.
abstract: This study aimed to improve bone regeneration using a timed-release system for periosteal expansion osteogenesis (TIME-PEO) using a shape memory alloy (SMA) mesh device and absorbable thread in a rabbit model.
  
  
  METHODS
  Twelve rabbits were used in this study. The device was inserted under the periosteum at the forehead, then pushed, bent, and attached to the bone surface and fixed with an absorbable thread. Rabbits were divided into groups C1 (5 weeks postoperatively without dynamic elevation), C2 (8 weeks postoperatively without dynamic elevation), T1 (5 weeks postoperatively from TIME-PEO), and T2 (8 weeks postoperatively from TIME-PEO). Newly formed bone was evaluated histologically and radiographically.
  
  
  RESULTS
  The newly formed bone volume to elevated bone volume ratio was 6.1% in C1, 21.9% in T1 15.5% in C2 and 36.0% in T2. These quantitative data indicate that TIME-PEO group had a significantly higher volume than that of the control group (P < 0.05). Histologically, multiple dome-shaped bones, outlined by thin and scattered trabeculae, over the original bone surface were evident in the T group.
  
  
  CONCLUSIONS
  This technique appears to be a promising clinical alternative for alveolar bone augmentation and introduces the new concept of "dynamic guided bone regeneration" for atrophic alveolar bone.
authors.affiliation: Division of Oral and Maxillofacial Surgery, Department of Oral Medicine and Surgery, Graduate School of Dentistry, Tohoku University, Japan. Electronic address: yamaken@dent.tohoku.ac.jp.
authors.forename: Kensuke
authors.initials: K
authors.lastname: Yamauchi
authors.affiliation: Division of Oral and Maxillofacial Surgery, Department of Oral Medicine and Surgery, Graduate School of Dentistry, Tohoku University, Japan.
authors.forename: Shinnosuke
authors.initials: S
authors.lastname: Nogami
authors.affiliation: Division of Oral and Maxillofacial Surgery, Department of Oral Medicine and Surgery, Graduate School of Dentistry, Tohoku University, Japan.
authors.forename: Gerardo
authors.initials: G
authors.lastname: Martinez-de la Cruz
authors.affiliation: Division of Oral and Maxillofacial Surgery, Department of Oral Medicine and Surgery, Graduate School of Dentistry, Tohoku University, Japan.
authors.forename: Bunichi
authors.initials: B
authors.lastname: Hirayama
authors.affiliation: Division of Oral Pathology, Department of Oral Medicine and Surgery, Graduate School of Dentistry, Tohoku University, Japan.
authors.forename: Yoshinaka
authors.initials: Y
authors.lastname: Shimizu
authors.affiliation: Division of Oral Pathology, Department of Oral Medicine and Surgery, Graduate School of Dentistry, Tohoku University, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kumamoto
authors.affiliation: Department of Oral and Maxillofacial Surgery, RWTH Aachen University, Germany.
authors.forename: Bernd
authors.initials: B
authors.lastname: Lethaus
authors.affiliation: Department of Cranio-Maxillofacial Surgery, Maastricht University Medical Center, The Netherlands.
authors.forename: Peter
authors.initials: P
authors.lastname: Kessler
authors.affiliation: Division of Oral and Maxillofacial Surgery, Department of Oral Medicine and Surgery, Graduate School of Dentistry, Tohoku University, Japan.
authors.forename: Tetsu
authors.initials: T
authors.lastname: Takahashi
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials; D001861:Bone Regeneration / Q000502:physiology*; D023421:Models, Animal; D009532:Nickel; D019857:Osteogenesis, Distraction / Q000379:methods*; D011817:Rabbits; D012886:Skull / Q000601:surgery*; D013526:Surgical Mesh; D014025:Titanium
chemical_list: D001672:Biocompatible Materials; C040654:titanium nickelide; D009532:Nickel; D014025:Titanium
keywords: Absorbable material; Distraction osteogenesis; Periosteal expansion osteogenesis; Shape memory alloy