title: Primary undifferentiated pleomorphic sarcoma of the breast in a young female: a case report.
abstract: BACKGROUND
  Undifferentiated pleomorphic sarcoma is a rare entity and requires extensive immunohistochemical markers to differentiate it from other tumors of the breast.
  
  
  METHODS
  We present a 29-year-old female with a left breast lump for 2 months. Initial diagnosis of malignant spindle cell tumor was done on core biopsy following which total mastectomy was done. After extensive sampling, on histology, highly pleomorphic spindle cells palisading the area of geographic necrosis with very high atypical mitosis were seen. As there was diagnostic difficulty, immunohistochemical antibody panel was used and diagnosis of undifferentiated pleomorphic sarcoma of the breast was made by exclusion.
  
  
  CONCLUSIONS
  Core biopsy with immunostaining is possibly superior to FNA as an initial diagnostic modality for breast masses with atypical features.
authors.affiliation: Department of Pathology, All India Institute of Medical Sciences, Sijua Village, Dumduma, Bhubaneswar, Orissa-17, India. drbanushree15@hotmail.com.|Present Address: Department of Pathology, Indira Gandhi Medical College, Puducherry, 605113, India. drbanushree15@hotmail.com.
authors.forename: Banushree C
authors.initials: BC
authors.lastname: Srinivasamurthy
authors.affiliation: Department of Pathology, Chennai Medical College, Trichy, India.
authors.forename: Ambedkar Raj
authors.initials: AR
authors.lastname: Kulandaivelu
authors.affiliation: Department of Pathology, All India Institute of Medical Sciences, Sijua Village, Dumduma, Bhubaneswar, Orissa-17, India.
authors.forename: Kaushik
authors.initials: K
authors.lastname: Saha
authors.affiliation: Department of Pathology, All India Institute of Medical Sciences, Sijua Village, Dumduma, Bhubaneswar, Orissa-17, India.
authors.forename: Arpita
authors.initials: A
authors.lastname: Saha
mesh_terms: D000328:Adult; D044963:Biopsy, Fine-Needle; D062005:Biopsy, Large-Core Needle; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D051677:Histiocytoma, Malignant Fibrous / Q000175:diagnosis* / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D007889:Leiomyoma / Q000175:diagnosis*; D003557:Phyllodes Tumor / Q000175:diagnosis*; D014746:Vimentin / Q000378:metabolism
chemical_list: D014746:Vimentin
keywords: Breast; Diagnostic challenge; Immunohistochemistry; Sarcoma; Undifferentiated