title: Copper-Catalyzed Regioselective Cascade Alkylation and Cyclocondensation of Quinoline N-Oxides with Diazo Esters: Direct Access to Conjugated π-Systems.
abstract: An inexpensive copper-catalyzed cascade regioselective alkylation, followed by cyclocondensation of quinoline N-oxides with α-diazo esters has been achieved successfully to provide heteroarene-containing conjugated π-systems. The developed method is simple, straightforward, and economical with a broad range of substrate scope. The dual role of copper catalyst in the C-H bond functionalization and in Lewis acid-promoted cyclization was explored.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur, 721302, India.
authors.forename: Aniruddha
authors.initials: A
authors.lastname: Biswas
authors.affiliation: Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur, 721302, India.
authors.forename: Ujjwal
authors.initials: U
authors.lastname: Karmakar
authors.affiliation: Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur, 721302, India.
authors.forename: Arun
authors.initials: A
authors.lastname: Pal
authors.affiliation: Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur, 721302, India. rsamanta@chem.iitkgp.ernet.in.
authors.forename: Rajarshi
authors.initials: R
authors.lastname: Samanta
keywords: C−H functionalization; carbenoids; conjugated π-systems; copper catalysis; quinoline n-oxide