title: Zinc inhibition of electron transfer: mechanism of beta receptor inhibition?
abstract: Zinc has been shown to inhibit β-receptor activation of adenylate cyclase at a post receptor site. We have postulated that the β-receptor is one of several receptors activated by reduction, followed by transmembrane elector transfer accelerated by GTP. GTP accelerates electron transfer in a model system and this accelerated electron transfer is inhibited by zinc. This could explain the mechanism of the post receptor inhibition by zinc of the adenylate cyclase stimulation which follows β-receptor activation.
authors.affiliation: a Clinical Medicine, V. A. Medical Center , Minneapolis , MN , USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Peterson
authors.affiliation: b Manitoba Institute of Cell Biology , Winnipeg , Manitoba , Canada.
authors.forename: J M
authors.initials: JM
authors.lastname: Gerrard