title: Bacterial sensitivity assessment of multifunctional polymeric coatings for airway stents.
abstract: Current interventional technology for pediatric airway obstruction consists of cardiovascular stents and silicon tubes. These devices are composed of permanent materials that have limitations in biocompatibility and mechanical properties that make them controversial for used in pediatrics. Bioresorbable stents offer a temporary intervention that dissolves in the body over time and can serve as a platform for local drug delivery. Here we investigate a novel approach to use an antibiotic, ciprofloxacin, as a polymerization initiator to synthesize poly(ciprofloxacin fumaric acid) (PCFA) and then a second polymer using gadodiamide as an initiator to synthesize poly(gadodiamide ciprofloxacin fumaric acid) (PGCFA). Polymer structure, degradation, thermal properties, and rheological behavior were analyzed. Ciprofloxacin released was determined and polymer degradation extracts were used in bacterial sensitivity assessments with four common airway pathogens. PCFA and PGCFA polymers and drug release properties were compared to our previously published polymer poly(fumaric acid) (PFA). These novel polymers enable new possibilities as coatings for bioresorbable biomedical applications that require antibiotic resistance and imaging capabilities. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2153-2161, 2017.
authors.affiliation: Department of Cardiovascular and Thoracic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, 75390-9130.
authors.forename: Amy C
authors.initials: AC
authors.lastname: Goodfriend
authors.affiliation: Department of Cardiovascular and Thoracic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, 75390-9130.
authors.forename: Tré R
authors.identifier: 0000-0003-3645-3442
authors.initials: TR
authors.lastname: Welch
authors.affiliation: Office of Research, Technology Translation Laboratory, University of Texas at Dallas, Richardson, Texas, 75080-3021.
authors.forename: Collin E
authors.initials: CE
authors.lastname: Thomas
authors.affiliation: Department of Bioengineering, University of Texas Arlington, Arlington, Texas, 76019.
authors.forename: Kytai T
authors.initials: KT
authors.lastname: Nguyen
authors.affiliation: Department of Otolaryngology, University of Texas Southwestern Medical Center, Dallas, Texas, 75390-9130.
authors.forename: Romaine F
authors.initials: RF
authors.lastname: Johnson
authors.affiliation: Department of Cardiovascular and Thoracic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, 75390-9130.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Forbess
mesh_terms: D020341:Absorbable Implants; D002939:Ciprofloxacin / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D020099:Coated Materials, Biocompatible; D004343:Drug Implants / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000254:growth & development*; D008826:Microbial Sensitivity Tests; D015607:Stents
chemical_list: D020099:Coated Materials, Biocompatible; D004343:Drug Implants; D002939:Ciprofloxacin
keywords: airway stent coatings; antimicrobial polymers; disk diffusion sensitivity assay; polymer characterization; polymer synthesis