title: [Impact of telmisartan on glomerular filtration in laparoscopic surgery. A double blinded randomised controlled study].
abstract: BACKGROUND
  Laparoscopic surgery has begun to replace a great number of procedures that were previously practiced using open or conventional techniques. This is due to the minimal invasion, small incisions, and short time recovery. However, it has come to knowledge, that the increase in intra-abdominal pressure due to carbon dioxide pneumoperitoneum during laparoscopic surgery causes cardiovascular, respiratory, endocrine, and renal alterations.
  
  
  OBJECTIVE
  To evaluate the nephroprotective effect of telmisartan, an angiotensin II AT1 receptor antagonist, on glomerular filtration in laparoscopic surgery.
  
  
  METHODS
  Analytical prospective, randomised, double-blind study was conducted on patients undergoing elective laparoscopic cholecystectomy. They were randomised into 2 groups, with the treatment group receiving a single dose of 40mg telmisartan orally 2hours prior to surgery, and the placebo group.
  
  
  RESULTS
  There were 20 patients in each group (n=40), with a mean age of 32.65 years in the treatment group. Plasma creatinine did not show any significant change in the different time lapse in which blood samples were taken, but creatinine clearance at the end of surgery (196.415±56.507 vs. 150.1995±75.081; p=0.034), and at 2 h postoperative period (162.105±44.756 vs. 113.235±31.228; p≤0.001) was statistically significant, which supports an increase in renal function in the telmisartan group.
  
  
  CONCLUSIONS
  The use of telmisartan, an angiotensin II AT1 receptor antagonist, offers renal protection during laparoscopic surgery.
authors.affiliation: Servicio de Cirugía General, Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México. Electronic address: alejandro_2424@hotmail.com.
authors.forename: Rodolfo Alejandro
authors.initials: RA
authors.lastname: Fuentes-Reyes
authors.affiliation: Servicio de Cirugía General, Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México.
authors.forename: Mariel Fernanda
authors.initials: MF
authors.lastname: Pacheco-Patiño
authors.affiliation: Servicio de Cirugía General, Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México.
authors.forename: Aurora Natalia
authors.initials: AN
authors.lastname: Ponce-Escobedo
authors.affiliation: Servicio de Cirugía General, Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México.
authors.forename: Gerardo Enrique
authors.initials: GE
authors.lastname: Muñoz-Maldonado
authors.affiliation: Servicio de Cirugía General, Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México.
authors.forename: Marco Antonio
authors.initials: MA
authors.lastname: Hernandez-Guedea
mesh_terms: D000142:Acidosis, Respiratory / Q000209:etiology; D058186:Acute Kidney Injury / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*; D000328:Adult; D047228:Angiotensin II Type 1 Receptor Blockers / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001562:Benzimidazoles / Q000494:pharmacology* / Q000627:therapeutic use; D001565:Benzoates / Q000494:pharmacology* / Q000627:therapeutic use; D015415:Biomarkers; D002245:Carbon Dioxide / Q000008:administration & dosage / Q000009:adverse effects; D017081:Cholecystectomy, Laparoscopic; D003404:Creatinine / Q000097:blood; D004311:Double-Blind Method; D017558:Elective Surgical Procedures; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D006801:Humans; D007327:Insufflation; D007431:Intraoperative Complications / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D011028:Pneumoperitoneum, Artificial / Q000009:adverse effects*; D011446:Prospective Studies; D000077333:Telmisartan; D055815:Young Adult
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D001562:Benzimidazoles; D001565:Benzoates; D015415:Biomarkers; D002245:Carbon Dioxide; D003404:Creatinine; D000077333:Telmisartan
keywords: Colecistectomía laparoscópica; Filtración glomerular; Glomerular filtration; Laparoscopic cholecystectomy; Neumoperitoneo; Pneumoperitoneum; Telmisartan; Telmisartán