title: Complete remission of thrombotic microangiopathy after treatment with eculizumab in a patient with non-Shiga toxin-associated bacterial enteritis: A case report.
abstract: To describe a case of complete remission of thrombotic microangiopathy after treatment with eculizumab in a patient with non-Shiga toxin-associated bacterial enteritis.
  
  
  METHODS
  Medical/surgical intensive care unit (ICU) of a university teaching hospital.A 62-year-old man presented to a local hospital with mucous and bloody stool persisting for 1 month and worsening abdominal pain for 2 weeks. He had thrombocytopenia and renal dysfunction and was admitted with a diagnosis of sepsis due to intraabdominal infection. However, he did not respond to antimicrobial therapy, and after 7 days he was transferred to the Chiba University Hospital ICU.Antimicrobial therapy was continued, and continuous hemodiafiltration was initiated on ICU day 3, but the patient's condition deteriorated and he became anuric. Plasma exchange (PE) was initiated on ICU day 11, but anuria and thrombocytopenia persisted. Intravenous eculizumab therapy was initiated on day 26 and resulted in quick recovery of urine output and platelet count and successful discontinuation of renal support.The diagnosis of thrombotic microangiopathy was established by the presence of schistocytes on the peripheral blood smear on ICU day 9. A plasma sample collected prior to initiation of PE showed a disintegrin-like and metalloproteinase with thrombospondin type 1 motifs member 13 (ADAMTS13) activity level of >10% (25.1%). The absence of both Shiga-toxin producing E coli in feces and anti-Shiga-toxin antibody in blood led to suspicion of atypical hemolytic uremic syndrome (aHUS). Genetic test identified a nonsynonymous mutation (p.Ala311Val) in the membrane cofactor protein gene (MCP).Although the pathological significance is currently unknown, this mutation may have been the cause of adult-onset aHUS in our patient. In this case, eculizumab was successfully introduced and discontinued, and the patient remained relapse-free after 1 year of follow-up. The duration of eculizumab therapy for patients with aHUS should be determined on a case-by-case basis and possibly according to the causative genetic mutation, even though discontinuation of eculizumab therapy once initiated is not generally recommended.
authors.affiliation: Department of Emergency and Critical Care Medicine, Graduate School of Medicine, Chiba University, Chiba Department of Pediatrics, Faculty of Medicine, Saga University, Saga Division of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo, Tokyo Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan.
authors.forename: Taku
authors.initials: T
authors.lastname: Omura
authors.forename: Eizo
authors.initials: E
authors.lastname: Watanabe
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Otsuka
authors.forename: Yoko
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Hideki
authors.initials: H
authors.lastname: Kato
authors.forename: Masaomi
authors.initials: M
authors.lastname: Nangaku
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Miyata
authors.forename: Shigeto
authors.initials: S
authors.lastname: Oda
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D017583:Hemodiafiltration; D006801:Humans; D008297:Male; D008875:Middle Aged; D010951:Plasma Exchange; D010976:Platelet Count; D057049:Thrombotic Microangiopathies / Q000188:drug therapy* / Q000382:microbiology*
chemical_list: D061067:Antibodies, Monoclonal, Humanized; C481642:eculizumab