title: 25-Hydroxyvitamin D in Patients With Melanoma and Factors Associated With Inadequate Levels.
abstract: OBJECTIVE
  Patients with melanoma appear to take extreme sun-protection measures, which could influence 25-hydroxyvitamin D [25(OH)D] levels. The aim of this study was to measure 25(OH)D levels in patients with cutaneous melanoma and identify factors associated with inadequate levels.
  
  
  METHODS
  Over a period of 1 year, we prospectively measured serum 25(OH)D in patients with cutaneous melanoma and used logistic regression analysis to identify environmental, phenotypic, and genotypic factors that were associated with insufficient and deficient levels.
  
  
  RESULTS
  Of 215 patients analyzed, 8.8% had deficient 25(OH)D levels (<10ng/mL) and just 24.7% had normal levels. Insufficient levels (<30ng/mL) were associated with obesity (odds ratio [OR], 4.2; 95% confidence interval [CI], 1.3-13.3) and blood sampling in autumn/winter (OR, 2.1; 95% CI, 1.1-4). Deficient levels (<10ng/mL) were associated with obesity (OR, 7.1; 95% CI, 1.1-46.9), blood sampling in autumn/winter (OR, 9.0; 95% CI, 1.7-47.0), absence of freckles (OR, 5.4; 95% CI, 1.2-23.4), and, with marginal significance, the presence of fewer than 2 nonsynonymous melanocortin-1 receptor (MC1R) polymorphisms (OR, 5.0; 95% CI, 0.9-28.9).
  
  
  CONCLUSIONS
  Some factors related to 25(OH)D levels, such as food, were not included in the analyses.
  
  
  CONCLUSIONS
  25(OH)D levels should be monitored in patients with melanoma and the need for oral supplements should be contemplated where appropriate.
authors.affiliation: Servicio de Dermatología, Instituto Valenciano de Dermatología, Valencia, España.
authors.forename: S
authors.initials: S
authors.lastname: Hernández-Ostiz
authors.affiliation: Servicio de Dermatología, Instituto Valenciano de Dermatología, Valencia, España.
authors.forename: M D
authors.initials: MD
authors.lastname: Pérez-Ramada
authors.affiliation: Servicio de Análisis Clínicos y Microbiología, Instituto Valenciano de Dermatología, Valencia, España.
authors.forename: B
authors.initials: B
authors.lastname: Ortiz
authors.affiliation: Servicio de Dermatología, Instituto Valenciano de Dermatología, Valencia, España.
authors.forename: C
authors.initials: C
authors.lastname: Requena
authors.affiliation: Servicio de Onco-Hematología, Hospital Clínic Universitari de Valencia, Valencia, España.
authors.forename: G
authors.initials: G
authors.lastname: Ribas
authors.affiliation: Servicio de Análisis Clínicos y Microbiología, Instituto Valenciano de Dermatología, Valencia, España.
authors.forename: E
authors.initials: E
authors.lastname: Aznar
authors.affiliation: Servicio de Dermatología, Instituto Valenciano de Dermatología, Valencia, España. Electronic address: eduardo_nagore@ono.com.
authors.forename: E
authors.initials: E
authors.lastname: Nagore
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000097:blood* / Q000453:epidemiology; D008548:Melanosis / Q000453:epidemiology; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics / Q000502:physiology; D009765:Obesity / Q000097:blood / Q000453:epidemiology; D020641:Polymorphism, Single Nucleotide; D044102:Receptor, Melanocortin, Type 1 / Q000235:genetics / Q000502:physiology; D012189:Retrospective Studies; D012621:Seasons; D012878:Skin Neoplasms / Q000097:blood* / Q000453:epidemiology; D012880:Skin Pigmentation; D013472:Sunlight; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood / Q000502:physiology / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000097:blood* / Q000188:drug therapy / Q000453:epidemiology; D000096142:Cutaneous Malignant Melanoma
chemical_list: D009363:Neoplasm Proteins; D044102:Receptor, Melanocortin, Type 1; D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: 25-Hydroxyvitamin D; 25-hidroxivitamina D; Cholecalciferol; Colecalciferol; MC1R; Melanocortin-1 receptor; Melanoma; Obesidad; Obesity; Radiación ultravioleta; Ultraviolet light