title: Spontaneous repigmentation of silvery hair in an infant with congenital hydrops fetalis and hypoproteinemia.
abstract: Silvery hair is a characteristic finding of 3 rare autosomal recessive disorders: Chédiak-Higashi syndrome (CHS), Elejalde syndrome (ES), and Griscelli syndrome (GS). We report the case of a 2-month-old male infant with transient silvery hair and generalized hypopigmentation of the skin and eyes who did not have one of these classic causative disorders. The patient was delivered at 35 weeks' gestation with congenital hydrops fetalis associated with a chromosomal abnormality (46,XY,add[2],[p23]), hypothyroidism, hypoproteinemia, and hypogammaglobulinemia. Over the course of follow-up, spontaneous brown repigmentation of the silvery hair was noted. We concluded that the silvery hair was induced by hypoproteinemia secondary to congenital hydrops fetalis.
authors.affiliation: Department of Dermatology, Hospital Clínic, University of Barcelona, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Galve
authors.affiliation: Department of Dermatology, University Hospital Son Espases, Palma de Mallorca, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Martín-Santiago
authors.affiliation: Department of Pediatrics, University Hospital Son Espases, Palma de Mallorca, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Clavero
authors.affiliation: Department of Pathology, University Hospital Son Espases, Palma de Mallorca, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Saus
authors.affiliation: Department of Genetics, University Hospital Son Espases, Palma de Mallorca, Spain.
authors.forename: Ramona
authors.initials: R
authors.lastname: Alfaro-Arenas
authors.affiliation: Department of Genetics, University Hospital Son Espases, Palma de Mallorca, Spain.
authors.forename: Angeles
authors.initials: A
authors.lastname: Pérez-Granero
authors.affiliation: Department of Pediatrics, University Hospital Son Espases, Palma de Mallorca, Spain.
authors.forename: Pere R
authors.initials: PR
authors.lastname: Balliu
authors.affiliation: Department of Dermatology, Hospital Clínic, University of Barcelona, Spain.
authors.forename: Juan
authors.initials: J
authors.lastname: Ferrando
mesh_terms: D000361:Agammaglobulinemia / Q000150:complications; D002869:Chromosome Aberrations; D003409:Congenital Hypothyroidism / Q000150:complications; D006201:Hair Diseases / Q000150:complications / Q000473:pathology*; D006801:Humans; D015160:Hydrops Fetalis; D017496:Hypopigmentation / Q000150:complications / Q000473:pathology*; D007019:Hypoproteinemia / Q000150:complications; D007223:Infant; D008297:Male; D012075:Remission, Spontaneous