title: Predictive factors for mortality in elderly Japanese patients with severe microscopic polyangiitis: A retrospective single-center study.
abstract: OBJECTIVE
  To determine mortality and its predictive factors in elderly Japanese patients with severe microscopic polyangiitis (MPA).
  
  
  METHODS
  This retrospective single-center study determined the mortality of 52 patients with MPA who were admitted to our geriatric medical center from 2002 to 2014. The variables at baseline, including patient demographics, clinical characteristics, and treatment, were analyzed for their association with mortality.
  
  
  RESULTS
  Mean age at onset of MPA was 73.2 years, and the one-year survival rate was 65.9%. Relapse was observed in 32.7%. Among variables at diagnosis, age, cardiomyopathy, central nervous system (CNS) involvement, alveolar hemorrhage, disease severity, the 1996 Five-Factor Score (FFS), and the 2009 FFS were associated with mortality in univariate analysis. Cardiomyopathy, CNS involvement, age >65 years, disease severity, Birmingham Vasculitis Activity Score, the 1996 FFS, and the 2009 FFS were associated with relapse-free survival in univariate analysis.
  
  
  CONCLUSIONS
  We investigated mortality and relapse-free survival and their predictive factors in elderly Japanese patients with severe MPA. Age, disease severity, the 1996 FFS, and the 2009 FFS at diagnosis were prognostic factors for both mortality and relapse-free survival.
authors.affiliation: a Department of Internal Medicine and Rheumatology , Juntendo University School of Medicine , Tokyo , Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Abe
authors.affiliation: a Department of Internal Medicine and Rheumatology , Juntendo University School of Medicine , Tokyo , Japan.
authors.forename: Naoto
authors.initials: N
authors.lastname: Tamura
authors.affiliation: b Geriatric General Medicine, Juntendo Tokyo Koto Geriatric Medical Center , Tokyo , Japan.
authors.forename: Kwang-Seok
authors.initials: KS
authors.lastname: Yang
authors.affiliation: c Clinical Research Support Center, Juntendo University School of Medicine , Tokyo , Japan , and.
authors.forename: Joe
authors.initials: J
authors.lastname: Matsuoka
authors.affiliation: a Department of Internal Medicine and Rheumatology , Juntendo University School of Medicine , Tokyo , Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kon
authors.affiliation: a Department of Internal Medicine and Rheumatology , Juntendo University School of Medicine , Tokyo , Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Yamaji
authors.affiliation: d Juntendo University School of Medicine , Tokyo , Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hashimoto
authors.affiliation: b Geriatric General Medicine, Juntendo Tokyo Koto Geriatric Medical Center , Tokyo , Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tsuda
authors.affiliation: a Department of Internal Medicine and Rheumatology , Juntendo University School of Medicine , Tokyo , Japan.
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Takasaki
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D055953:Microscopic Polyangiitis / Q000453:epidemiology*; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies; D015996:Survival Rate
keywords: Anti-phospholipid antibody; Elderly patients; Microscopic polyangiitis; Mortality