title: A systematic review and meta-analysis of the antibiotic treatment for infectious bovine keratoconjunctivitis: an update.
abstract: Infectious bovine keratoconjunctivitis (IBK) is a common and important disease of calves. Without effective vaccines, antibiotic therapy is often implemented to minimize the impact of IBK. This review updates a previously published systematic review regarding comparative efficacy for antibiotic treatments of IBK. Available years of Centre for Biosciences and Agriculture International and MEDLINE databases were searched, including non-English results. Also searched were the American Association of Bovine Practitioners and World Buiatrics Congress conference proceedings from 1996 to 2016, reviews since 2013, reference lists from relevant trials, and U.S. Food and Drug Administration New Animal Drug Application summaries. Eligible studies assessed antibiotic treatment of naturally-occurring IBK in calves randomly allocated to group at the individual level. Outcomes of interest were clinical score, healing time, unhealed ulcer risk, and ulcer surface area. A mixed-effects model comparing active drug with placebo was employed for all outcomes. Heterogeneity was assessed visually and using Cochran's Q-test. Thirteen trials assessing nine treatments were included. Compared with placebo, most antibiotic treatments were effective. There was evidence that the treatment effect differed by day of outcome measurement. Visually, the largest differences were observed 7-14 days post-treatment. These results indicate improved IBK healing with many antibiotics and suggest the need for randomized trials comparing different antibiotic treatments.
authors.affiliation: Department of Veterinary Diagnostic and Production Animal Medicine,College of Veterinary Medicine,Iowa State University,Ames,Iowa 500010,USA.
authors.forename: J N
authors.initials: JN
authors.lastname: Cullen
authors.affiliation: Department of Statistics,College of Agriculture and Life Sciences,Iowa State University,Ames,Iowa,USA.
authors.forename: C
authors.initials: C
authors.lastname: Yuan
authors.forename: S
authors.initials: S
authors.lastname: Totton
authors.affiliation: Department of Veterinary Diagnostic and Production Animal Medicine,College of Veterinary Medicine,Iowa State University,Ames,Iowa 500010,USA.
authors.forename: R
authors.initials: R
authors.lastname: Dzikamunhenga
authors.affiliation: Department of Veterinary Diagnostic and Production Animal Medicine,College of Veterinary Medicine,Iowa State University,Ames,Iowa 500010,USA.
authors.forename: J F
authors.initials: JF
authors.lastname: Coetzee
authors.affiliation: Department of Statistics,College of Agriculture and Life Sciences,Iowa State University,Ames,Iowa,USA.
authors.forename: N
authors.initials: N
authors.lastname: da Silva
authors.affiliation: Department of Veterinary Diagnostic and Production Animal Medicine,College of Veterinary Medicine,Iowa State University,Ames,Iowa 500010,USA.
authors.forename: C
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Veterinary Diagnostic and Production Animal Medicine,College of Veterinary Medicine,Iowa State University,Ames,Iowa 500010,USA.
authors.forename: A M
authors.initials: AM
authors.lastname: O'Connor
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D015982:Bias; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000517:prevention & control; D007639:Keratoconjunctivitis, Infectious / Q000188:drug therapy* / Q000517:prevention & control; D016955:Moraxella bovis / Q000187:drug effects* / Q000276:immunology; D045828:Moraxellaceae Infections / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary*
chemical_list: D000900:Anti-Bacterial Agents
keywords: antibiotics; infectious bovine keratoconjunctivitis; meta-analysis; pinkeye; systematic review