title: Association between TNF-α-308G>A and -238G>A gene polymorphisms and TNF-α serum levels in Mexican colorectal cancer patients.
abstract: The objective of this study was to examine the association between TNF-α serum levels and -308G>A and -238G>A polymorphisms in the corresponding gene by comparing healthy subjects to colorectal cancer (CRC) patients from a Mexican population. Serum levels of TNF-α were found to significantly differ between CRC patients and controls (P = 0.001), but no relationship between the -308G>A and -238G>A polymorphisms and increased CRC risk was established (P > 0.05). However, an association between the -308G>A variant and disease became evident when the distribution of AA-GA genotypes was examined in patients with hematologic toxicity (neutropenia) and those without (odds ratio = 3.356, 95% confidence interval = 1.295- 8.698, P = 0.013). The GG haplotype was more common in controls than CRC patients, with a frequency of 0.85 among the former, but this difference was not significant (P > 0.05). In conclusion, TNF-α serum levels and AA-AG genotypes of the TNF-α-308G>A polymorphism may significantly contribute to CRC susceptibility in the population examined in this investigation.
authors.affiliation: Genetics Molecular Laboratory, Genetics Division, Western Biomedical Research Center, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.|Doctorate Program in Human Genetics, Health Sciences University Center, University of Guadalajara, Guadalajara, Jalisco, Mexico.
authors.forename: I A
authors.initials: IA
authors.lastname: Gutiérrez-Hurtado
authors.affiliation: Inmmunopharmacology Laboratory, Exact and Engineering Sciences University Center, University of Guadalajara, Guadalajara, Jalisco, Mexico.
authors.forename: A M
authors.initials: AM
authors.lastname: Puebla-Pérez
authors.affiliation: Inmmunopharmacology Laboratory, Exact and Engineering Sciences University Center, University of Guadalajara, Guadalajara, Jalisco, Mexico.
authors.forename: J I
authors.initials: JI
authors.lastname: Delgado-Saucedo
authors.affiliation: Genetics Division, Western Biomedical Research Center, Western National Medical Center, Guadalajara, Jalisco, Mexico.
authors.forename: L E
authors.initials: LE
authors.lastname: Figuera
authors.affiliation: Mutagenesis Laboratory, Molecular Medicine Division, Western Biomedical Research Center, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.
authors.forename: G M
authors.initials: GM
authors.lastname: Zúñiga-González
authors.affiliation: Genetics Molecular Laboratory, Genetics Division, Western Biomedical Research Center, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.|Doctorate Program in Human Genetics, Health Sciences University Center, University of Guadalajara, Guadalajara, Jalisco, Mexico.
authors.forename: K
authors.initials: K
authors.lastname: Gomez-Mariscal
authors.affiliation: UMAE, Specialty Hospital, Oncology Service, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.
authors.forename: C A
authors.initials: CA
authors.lastname: Ronquillo-Carreón
authors.affiliation: Genetics Molecular Laboratory, Genetics Division, Western Biomedical Research Center, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.
authors.forename: M P
authors.initials: MP
authors.lastname: Gallegos-Arreola
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000097:blood* / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood* / Q000235:genetics
chemical_list: D014409:Tumor Necrosis Factor-alpha