title: Discovery of Novel Biomarkers for Alzheimer's Disease from Blood.
abstract: Blood-based biomarkers for Alzheimer's disease would be very valuable because blood is a more accessible biofluid and is suitable for repeated sampling. However, currently there are no robust and reliable blood-based biomarkers for practical diagnosis. In this study we used a knowledge-based protein feature pool and two novel support vector machine embedded feature selection methods to find panels consisting of two and three biomarkers. We validated these biomarker sets using another serum cohort and an RNA profile cohort from the brain. Our panels included the proteins ECH1, NHLRC2, HOXB7, FN1, ERBB2, and SLC6A13 and demonstrated promising sensitivity (>87%), specificity (>91%), and accuracy (>89%).
authors.affiliation: School of Medicine, Plymouth University Peninsula Schools of Medicine and Dentistry (PUPSMD), Drake Circus, Plymouth PL4 8AA, UK.
authors.forename: Jintao
authors.initials: J
authors.lastname: Long
authors.affiliation: School of Computing, Electronics and Mathematics, Plymouth University, Drake Circus, Plymouth PL4 8AA, UK.
authors.forename: Genhua
authors.initials: G
authors.lastname: Pan
authors.affiliation: School of Computing, Electronics and Mathematics, Plymouth University, Drake Circus, Plymouth PL4 8AA, UK.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Ifeachor
authors.affiliation: School of Biomedical & Healthcare Sciences, Plymouth University Peninsula Schools of Medicine and Dentistry (PUPSMD), Drake Circus, Plymouth PL4 8AA, UK.
authors.forename: Robert
authors.initials: R
authors.lastname: Belshaw
authors.affiliation: School of Medicine, Plymouth University Peninsula Schools of Medicine and Dentistry (PUPSMD), Drake Circus, Plymouth PL4 8AA, UK.
authors.forename: Xinzhong
authors.initials: X
authors.lastname: Li
mesh_terms: D000544:Alzheimer Disease / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001921:Brain / Q000378:metabolism; D019748:Carbon-Carbon Double Bond Isomerases / Q000235:genetics / Q000378:metabolism; D005353:Fibronectins / Q000235:genetics / Q000378:metabolism; D050485:GABA Plasma Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D051188:Knowledge Bases; D020543:Proteome / Q000032:analysis*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics / Q000378:metabolism; D012680:Sensitivity and Specificity; D059467:Transcriptome
chemical_list: D015415:Biomarkers; D019748:Carbon-Carbon Double Bond Isomerases; D005353:Fibronectins; D050485:GABA Plasma Membrane Transport Proteins; D018398:Homeodomain Proteins; D020543:Proteome; D012333:RNA, Messenger; D018719:Erb-b2 Receptor Tyrosine Kinases; C067625:FN1 protein, human; C490538:HOXB7 protein, human; C493418:SLC6A13 protein, human; C508053:ERBB2 protein, human; C085575:delta(3,5),delta(2,4)-dienoyl-CoA isomerase