title: [Urinary metabolomics study of the effects of Scutellaria baicalensis Georgi ethanol extract on D-galactose-induced rats].
abstract: The purpose of this study is to evaluate the anti-aging effects and reveal the underlying mechanism of Scutellaria baicalensis Georgi ethanol extract (SBG) in D-galactose-induced rats. Fifty rats were randomly divided into five groups: vehicle control group, D-galactose group, and D-galactose combined with 50, 100, 200 mg x kg(-1) SBG. A rat aging model was induced by injecting subcutaneously D-galactose (100 mg x kg(-1)) for ten weeks. At the tenth week, the locomotor activity (in open-field test) and the learning and memory abilities (in Morris water maze test) were examined respectively. The urine was collected using metabolic cages and analyzed by high-resolution 1H NMR spectroscopy combined with multivariate statistical analyses. The SBG at doses of 50, 100 and 200 mg x kg(-1) treatments groups could significantly ameliorate aging process in rats' cognitive performance. The 50, 100, 200 mg x kg(-1) SBG regulated citrate, pyruvate, lactate, trimethylamine (TMA), pantothenate, β-hydroxybutyrate in urine favorably toward the control group. These biochemical changes are related to the disturbance in energy metabolism, glycometabolism and microbiome metabolism, which is helpful to further understanding the D-galactose induced aging rats and the therapeutic mechanism of SBG.
authors.forename: Yan-fen
authors.initials: YF
authors.lastname: Chang
authors.forename: Wen-xia
authors.initials: WX
authors.lastname: Gong
authors.forename: Yan-hong
authors.initials: YH
authors.lastname: Zheng
authors.forename: Jian-wei
authors.initials: JW
authors.lastname: Li
authors.forename: Yu-zhi
authors.initials: YZ
authors.lastname: Zhou
authors.forename: Xue-mei
authors.initials: XM
authors.lastname: Qin
authors.forename: Guan-hua
authors.initials: GH
authors.lastname: Du
mesh_terms: D000375:Aging / Q000187:drug effects*; D000818:Animals; D005690:Galactose; D008568:Memory / Q000187:drug effects; D055442:Metabolome; D055432:Metabolomics; D010936:Plant Extracts / Q000493:pharmacokinetics* / Q000652:urine; D051381:Rats; D031364:Scutellaria baicalensis / Q000737:chemistry*
chemical_list: D010936:Plant Extracts; C499814:Scutellaria baicalensis extract; D005690:Galactose