title: Clonorchis sinensis, an oriental liver fluke, as a human biological agent of cholangiocarcinoma: a brief review.
abstract: Parasitic diseases remain an unarguable public health problem worldwide. Liver fluke Clonorchis sinensis is a high risk pathogenic parasitic helminth which is endemic predominantly in Asian countries, including Korea, China, Taiwan, Vietnam, and the far eastern parts of Russia, and is still actively transmitted. According to the earlier 8th National Survey on the Prevalence of Intestinal Parasitic Infections in 2012, C. sinensis was revealed as the parasite with highest prevalence of 1.86% in general population among all parasite species surveyed in Korea. This fluke is now classified under one of the definite Group 1 human biological agents (carcinogens) by International Agency of Research on Cancer (IARC) along with two other parasites, Opisthorchis viverrini and Schistosoma haematobium. C. sinensis infestation is mainly linked to liver and biliary disorders, especially cholangiocarcinoma (CCA). For the purposes of this mini-review, we will only focus on C. sinensis and review pathogenesis and carcinogenesis of clonorchiasis, disease condition by C. sinensis infestation, and association between C. sinensis infestation and CCA. In this presentation, we briefly consider the current scientific status for progression of CCA by heavy C. sinensis infestation from the food-borne trematode and development of CCA. [BMB Reports 2016; 49(11): 590-597].
authors.affiliation: Department of Parasitology and Tropical Medicine, School of Medicine, Inha University, Incheon 22212, Korea.
authors.forename: Tong-Soo
authors.initials: TS
authors.lastname: Kim
authors.affiliation: Department of Convergence Medicine, College of Medicine, University of Ulsan, Asan Institute for Life Sciences, Asan Medical Center, Seoul 05505, Korea.
authors.forename: Jhang Ho
authors.initials: JH
authors.lastname: Pak
authors.affiliation: Department of Biotechnology, Konkuk University, Chungju 27478, Korea.
authors.forename: Jong-Bo
authors.initials: JB
authors.lastname: Kim
authors.affiliation: Department of Biotechnology, Konkuk University, Chungju 27478, Korea.
authors.forename: Young Yil
authors.initials: YY
authors.lastname: Bahk
mesh_terms: D000818:Animals; D001094:Arachidonate 5-Lipoxygenase / Q000378:metabolism; D001650:Bile Duct Neoplasms / Q000209:etiology* / Q000469:parasitology / Q000473:pathology; D018281:Cholangiocarcinoma / Q000209:etiology* / Q000469:parasitology / Q000473:pathology; D003003:Clonorchiasis / Q000150:complications / Q000469:parasitology / Q000473:pathology; D003004:Clonorchis sinensis / Q000472:pathogenicity* / Q000502:physiology; D051546:Cyclooxygenase 2 / Q000378:metabolism; D004249:DNA Damage; D004260:DNA Repair; D006801:Humans; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species; D001094:Arachidonate 5-Lipoxygenase; D051546:Cyclooxygenase 2