title: The MRI-detected osteophyte score is a predictor for undergoing joint replacement in patients with end-stage knee osteoarthritis.
abstract: OBJECTIVE
  The aim of this prospective cohort study was to examine whether MRI-detected osteoarthritis (OA)-structural changes at baseline could predict knee OA patients who would undergo total knee arthroplasty (TKA).
  
  
  METHODS
  In total, 128 end-stage medial-type knee OA patients were enrolled and followed up for 6 months. MRI using the whole-organ MRI scoring (WORMS) method, radiographic findings, visual analog scale (VAS) for pain and a patient-oriented outcome measure, and the Japanese Knee Osteoarthritis Measure (JKOM) were recorded at baseline. The area under the curve (AUC) was estimated to determine the discriminative value of the prediction models.
  
  
  RESULTS
  While 74 patients (57.8%) did not undergo TKA, the remaining 54 patients (42.2%) underwent TKA during this period. The AUCs of the receiver operating characteristic (ROC) curve for the activities of daily living (ADL) score evaluated by the JKOM ADL score [0.70 (95% CI: 0.60-0.79)] and osteophyte score [0.72 (0.64-0.81)] were 0.70 or greater. The JKOM ADL score (17/40) and the osteophyte score (30/98) showed relative risks (RR) of 2.61 (1.32-5.15) and 3.01 (1.39-6.52) for undergoing TKA, respectively.
  
  
  CONCLUSIONS
  The osteophyte score detected by MRI, in addition to ADL score, was found to be an important factor in determining whether the patient should undergo TKA.
authors.affiliation: a Department of Medicine for Orthopaedics and Motor Organ , Juntendo University Graduate School of Medicine , Tokyo , Japan.|b Sportology Center, Juntendo University Graduate School of Medicine , Tokyo , Japan , and.
authors.forename: Lizu
authors.initials: L
authors.lastname: Liu
authors.affiliation: a Department of Medicine for Orthopaedics and Motor Organ , Juntendo University Graduate School of Medicine , Tokyo , Japan.|b Sportology Center, Juntendo University Graduate School of Medicine , Tokyo , Japan , and.
authors.forename: Muneaki
authors.initials: M
authors.lastname: Ishijima
authors.affiliation: a Department of Medicine for Orthopaedics and Motor Organ , Juntendo University Graduate School of Medicine , Tokyo , Japan.
authors.forename: Haruka
authors.initials: H
authors.lastname: Kaneko
authors.affiliation: a Department of Medicine for Orthopaedics and Motor Organ , Juntendo University Graduate School of Medicine , Tokyo , Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Sadatsuki
authors.affiliation: a Department of Medicine for Orthopaedics and Motor Organ , Juntendo University Graduate School of Medicine , Tokyo , Japan.
authors.forename: Shinnosuke
authors.initials: S
authors.lastname: Hada
authors.affiliation: a Department of Medicine for Orthopaedics and Motor Organ , Juntendo University Graduate School of Medicine , Tokyo , Japan.
authors.forename: Mayuko
authors.initials: M
authors.lastname: Kinoshita
authors.affiliation: b Sportology Center, Juntendo University Graduate School of Medicine , Tokyo , Japan , and.
authors.forename: Takako
authors.initials: T
authors.lastname: Aoki
authors.affiliation: a Department of Medicine for Orthopaedics and Motor Organ , Juntendo University Graduate School of Medicine , Tokyo , Japan.
authors.forename: Ippei
authors.initials: I
authors.lastname: Futami
authors.affiliation: a Department of Medicine for Orthopaedics and Motor Organ , Juntendo University Graduate School of Medicine , Tokyo , Japan.|c Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine , Tokyo , Japan.
authors.forename: Anwarjan
authors.initials: A
authors.lastname: Yusup
authors.affiliation: a Department of Medicine for Orthopaedics and Motor Organ , Juntendo University Graduate School of Medicine , Tokyo , Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Arita
authors.affiliation: a Department of Medicine for Orthopaedics and Motor Organ , Juntendo University Graduate School of Medicine , Tokyo , Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Shiozawa
authors.affiliation: a Department of Medicine for Orthopaedics and Motor Organ , Juntendo University Graduate School of Medicine , Tokyo , Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Takazawa
authors.affiliation: a Department of Medicine for Orthopaedics and Motor Organ , Juntendo University Graduate School of Medicine , Tokyo , Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ikeda
authors.affiliation: a Department of Medicine for Orthopaedics and Motor Organ , Juntendo University Graduate School of Medicine , Tokyo , Japan.|b Sportology Center, Juntendo University Graduate School of Medicine , Tokyo , Japan , and.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kaneko
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D019645:Arthroplasty, Replacement, Knee; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D054850:Osteophyte / Q000000981:diagnostic imaging* / Q000473:pathology; D011446:Prospective Studies
keywords: Activity of daily living; MRI; Osteoarthritis; Osteophyte; Total knee arthroplasty