title: Guaiane-Type Sesquiterpenoids from Fissistigma oldhamii Inhibit the Proliferation of Synoviocytes.
abstract: Three guaiane-type sesquiterpenoids, dysodensiols G-I (1-3), together with five known sesquiterpenoids (4-8) were isolated from the stems ofFissistigma oldhamii(Hemsl.) Merr. Compound1represents the first example of an ene(6 → 5)-abeo-14-norguaiane sesquiterpenoid derived from natural products. Their structures were elucidated by a combination of 1D and 2D NMR and MS spectra. The absolute configuration of2was determined by an X-ray crystallographic analysis. The inhibitory effect of all compounds on the proliferation of primary synovial cells was evaluated. Compound3showed a potent inhibitory effect on the proliferation of synoviocytes with an IC50value of 1.0µM.
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China.
authors.forename: Xue-Ming
authors.initials: XM
authors.lastname: Zhou
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China.
authors.forename: Cai-Juan
authors.initials: CJ
authors.lastname: Zheng
authors.affiliation: Fujian University of Traditional Chinese Medicine College Of Pharmacy, Fuzhou, Fujian, P. R. China.
authors.forename: Yu-Qin
authors.initials: YQ
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China.
authors.forename: Xiao-Peng
authors.initials: XP
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China.
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Song
authors.affiliation: Fujian University of Traditional Chinese Medicine College Of Pharmacy, Fuzhou, Fujian, P. R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.affiliation: Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China.
authors.forename: Guang-Ying
authors.initials: GY
authors.lastname: Chen
mesh_terms: D000818:Animals; D029061:Annonaceae / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects; D018360:Crystallography, X-Ray / Q000379:methods; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods; D015394:Molecular Structure; D045792:Norisoprenoids / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045789:Sesquiterpenes, Guaiane / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000070918:Synoviocytes / Q000166:cytology / Q000187:drug effects*
chemical_list: D004365:Drugs, Chinese Herbal; D045792:Norisoprenoids; D012717:Sesquiterpenes; D045789:Sesquiterpenes, Guaiane; C421026:guaiane