title: hsa_circRNA_103636: potential novel diagnostic and therapeutic biomarker in Major depressive disorder.
abstract: OBJECTIVE
  This study aimed to determine whether circular RNA (circRNA) molecules in peripheral blood mononuclear cells (PBMCs) could be used as novel non-invasive biomarkers for major depressive disorder (MDD).
  
  
  METHODS
  Differentially expressed circRNAs were screened using an Arraystar Human CircRNA Array (which includes 13,617 human circRNAs) and qRT-PCR. Thirty MDD patients were randomly selected to retest the circRNA levels after 4-week and 8-week antidepressant regimens.
  
  
  RESULTS
  Four differentially expressed circRNAs were identified between MDD patients and controls, and only down-regulated hsa_circRNA_103636 was significantly altered after the 8-week treatment in MDD patients.
  
  
  CONCLUSIONS
  These results suggest that altered expression of hsa_circRNA_103636 in PBMCs is a potential novel biomarker for the diagnosis and treatment of MDD.
authors.affiliation: Department of Health Care, Changzhou Maternal & Child Health Care Hospital Affiliated with Nanjing Medical University, Changzhou, People's Republic of China.
authors.forename: Xuelian
authors.initials: X
authors.lastname: Cui
authors.affiliation: Department of Rehabilitation, No. 102 Hospital of Chinese People's Liberation Army, Changzhou, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Niu
authors.affiliation: Prevention & Treatment Center for Psychological Diseases, No. 102 Hospital of Chinese People's Liberation Army, Changzhou, People's Republic of China.
authors.forename: Lingming
authors.initials: L
authors.lastname: Kong
authors.affiliation: Prevention & Treatment Center for Psychological Diseases, No. 102 Hospital of Chinese People's Liberation Army, Changzhou, People's Republic of China.
authors.forename: Mingjun
authors.initials: M
authors.lastname: He
authors.affiliation: Prevention & Treatment Center for Psychological Diseases, No. 102 Hospital of Chinese People's Liberation Army, Changzhou, People's Republic of China.
authors.forename: Kunhong
authors.initials: K
authors.lastname: Jiang
authors.affiliation: Department of Neurology, No. 102 Hospital of Chinese People's Liberation Army, Changzhou, People's Republic of China.
authors.forename: Shengdong
authors.initials: S
authors.lastname: Chen
authors.affiliation: Clinical Laboratory, No. 102 Hospital of Chinese People's Liberation Army, Changzhou, People's Republic of China.
authors.forename: Aifang
authors.initials: A
authors.lastname: Zhong
authors.affiliation: Gopath Diagnostic Laboratory Co Ltd, No. 801, Changzhou, People's Republic of China.
authors.forename: Wanshuai
authors.initials: W
authors.lastname: Li
authors.affiliation: Gopath Diagnostic Laboratory Co Ltd, No. 801, Changzhou, People's Republic of China.|Gopath Laboratories LLC, 1351 Barclay Blvd, Buffalo Grove, USA.
authors.forename: Jim
authors.initials: J
authors.lastname: Lu
authors.affiliation: Prevention & Treatment Center for Psychological Diseases, No. 102 Hospital of Chinese People's Liberation Army, Changzhou, People's Republic of China.
authors.forename: Liyi
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000175:diagnosis* / Q000188:drug therapy; D015536:Down-Regulation; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012313:RNA / Q000097:blood* / Q000235:genetics / Q000378:metabolism; D000079962:RNA, Circular; D060888:Real-Time Polymerase Chain Reaction
chemical_list: D000928:Antidepressive Agents; D015415:Biomarkers; D000079962:RNA, Circular; D012313:RNA
keywords: biomarker; circRNA; early diagnosis; major depressive disorder; peripheral blood mononuclear cells; prognosis