title: Nanostructured Drugs Embedded into a Polymeric Matrix: Vinpocetine/PVP Hybrids Investigated by Debye Function Analysis.
abstract: Microcrystalline vinpocetine, coground with cross-linked polyvinylpyrrolidone, affords hybrids containing nanosized drug nanocrystals, the size and size distributions of which depend on milling times and drug-to-polymer weight ratios. Using an innovative approach to microstructural characterization, we analyzed wide-angle X-ray total scattering data by the Debye function analysis and demonstrated the possibility to characterize pharmaceutical solid dispersions obtaining a reliable quantitative view of the physicochemical status of the drug dispersed in an amorphous carrier. The microstructural properties derived therefrom have been successfully employed in reconciling the enigmatic difference in behavior between in vitro and in vivo solubility tests performed on nanosized vinpocetine embedded in a polymeric matrix.
authors.affiliation: Department of Chemistry, University of Cambridge , Lensfield Road, CB2 1EW, Cambridge, U.K.|Department of Chemical and Pharmaceutical Sciences, University of Trieste , 34127 Trieste, Italy.
authors.forename: Dritan
authors.initials: D
authors.lastname: Hasa
authors.affiliation: Department of Sciences and High Technology and To.Sca.Lab, University of Insubria , 22100 Como, Italy.
authors.forename: Carlotta
authors.initials: C
authors.lastname: Giacobbe
authors.affiliation: Department of Chemical and Pharmaceutical Sciences, University of Trieste , 34127 Trieste, Italy.
authors.forename: Beatrice
authors.initials: B
authors.lastname: Perissutti
authors.affiliation: Department of Chemical and Pharmaceutical Sciences, University of Trieste , 34127 Trieste, Italy.
authors.forename: Dario
authors.initials: D
authors.lastname: Voinovich
authors.affiliation: Department of Engineering and Architecture, University of Trieste , 34127 Trieste, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Grassi
authors.affiliation: Swiss Light Source, Paul Scherrer Institute , CH-5232 Villigen, Switzerland.
authors.forename: Antonio
authors.initials: A
authors.lastname: Cervellino
authors.affiliation: Department of Sciences and High Technology and To.Sca.Lab, University of Insubria , 22100 Como, Italy.
authors.forename: Norberto
authors.initials: N
authors.lastname: Masciocchi
authors.affiliation: Istituto di Cristallografia and To.Sca.Lab, Consiglio Nazionale delle Ricerche , 22100 Como, Italy.
authors.forename: Antonietta
authors.initials: A
authors.lastname: Guagliardi
mesh_terms: D004337:Drug Carriers / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011205:Povidone / Q000737:chemistry*; D014748:Vinca Alkaloids / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D011108:Polymers; D014748:Vinca Alkaloids; C013983:vinpocetine; D011205:Povidone
keywords: Debye scattering equation; mechanical activation; solid dispersion; total scattering; vinpocetine