title: HIV-1 Genetic Diversity and Drug Resistance Mutations Among Treatment-Naive Adult Patients in Suriname.
abstract: The molecular epidemiologic profile of HIV-1 in Suriname was determined through protease (PR) and reverse transcriptase (RT) sequences obtained from HIV-1 strains collected from 100 drug-naive HIV-1-infected persons. Subtype determination revealed that most viruses were of subtype B (94.9%) in both PR and RT genomic regions, followed by B/D recombinants (5.1%). Analysis of drug resistance mutations showed only one transmitted dug resistance mutation (TDRM) (V75M) in a single strain. The genetic data obtained can serve as a baseline for Suriname to monitor emerging mutations. This study reveals that the HIV-1 epidemic in Suriname is still characterized by a low TDRM rate (1%) and a low level of subtype diversity. However, both genes display a high genetic polymorphism. This high polymorphism may ultimately lead to drug resistance. Continuous monitoring of the baseline resistance is therefore a prerequisite to safeguard effective long-term treatment for people living with HIV-1 in Suriname.
authors.affiliation: 1 Ministry of Health in Suriname , Paramaribo, Suriname .
authors.forename: Firoz
authors.initials: F
authors.lastname: Abdoel Wahid
authors.affiliation: 2 Department of Biochemistry, 'Prof. Dr. Paul C. Flu' Institute for Biomedical Sciences , Paramaribo, Suriname .
authors.forename: Rachel
authors.initials: R
authors.lastname: Sno
authors.affiliation: 3 Laboratoire des Interactions Virus-Hôtes, Institut Pasteur de la Guyane , Cayenne, Guyane Française.
authors.forename: Edith
authors.initials: E
authors.lastname: Darcissac
authors.affiliation: 3 Laboratoire des Interactions Virus-Hôtes, Institut Pasteur de la Guyane , Cayenne, Guyane Française.
authors.forename: Anne
authors.initials: A
authors.lastname: Lavergne
authors.affiliation: 4 Department of Biochemistry, Faculty of Medical Sciences, Anton de Kom Universiteit van Suriname , Paramaribo, Suriname .
authors.forename: Malti R
authors.initials: MR
authors.lastname: Adhin
authors.affiliation: 3 Laboratoire des Interactions Virus-Hôtes, Institut Pasteur de la Guyane , Cayenne, Guyane Française.
authors.forename: Vincent
authors.initials: V
authors.lastname: Lacoste
mesh_terms: D000293:Adolescent; D000328:Adult; D019380:Anti-HIV Agents / Q000494:pharmacology*; D003430:Cross-Sectional Studies; D024882:Drug Resistance, Viral; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D060005:Genotyping Techniques; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000145:classification / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D020125:Mutation, Missense; D013532:Suriname; D055815:Young Adult
chemical_list: D019380:Anti-HIV Agents
keywords: HIV genotyping; Suriname; drug resistance mutations