title: Differential mesolimbic and prefrontal alterations during reward anticipation and consummation in positive and negative schizotypy.
abstract: Schizotypy is associated with anhedonia. However, previous findings on the neural substrates of anhedonia in schizotypy are mixed. In the present study, we measured the neural substrates associated with reward anticipation and consummation in positive and negative schizotypy using functional MRI. The Monetary Incentive Delay task was administered to 33 individuals with schizotypy (18 positive schizotypy (PS),15 negative schizotypy (NS)) and 22 healthy controls. Comparison between schizotypy individuals and controls were performed using two-sample T tests for contrast images involving gain versus non-gain anticipation condition and gain versus non-gain consummation condition. Multiple comparisons were corrected using Monte Carlo Simulation correction of p<.05. The results showed no significant difference in brain activity between controls and schizotypy individuals as a whole during gain anticipation or consummation. However, during the consummatory phase, NS individuals rather than PS individuals showed diminished left amygdala and left putamen activity compared with controls. We observed significantly weaker activation at the left ventral striatum during gain anticipation in NS individuals compared with controls. PS individuals, however, exhibited enhanced right ventral lateral prefrontal activity. These findings suggest that different dimensions of schizotypy may be underlied by different neural dysfunctions in reward anticipation and consummation.
authors.affiliation: Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics (MOE & STCSM), East China Normal University, Shanghai, China; Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Yan
authors.affiliation: Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Psychiatry, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK.
authors.forename: Li
authors.initials: L
authors.lastname: Su
authors.affiliation: Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Xu
authors.affiliation: Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
authors.forename: Da-Zhi
authors.initials: DZ
authors.lastname: Yin
authors.affiliation: Shanghai Key Laboratory of MRI, East China Normal University, Shanghai, China.
authors.forename: Ming-Xia
authors.initials: MX
authors.lastname: Fan
authors.affiliation: Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics (MOE & STCSM), East China Normal University, Shanghai, China.
authors.forename: Ci-Ping
authors.initials: CP
authors.lastname: Deng
authors.affiliation: Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics (MOE & STCSM), East China Normal University, Shanghai, China.
authors.forename: Zhao-Xin
authors.initials: ZX
authors.lastname: Wang
authors.affiliation: Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Castle Peak Hospital, Hong Kong Special Administrative Region, China.
authors.forename: Simon S Y
authors.initials: SS
authors.lastname: Lui
authors.affiliation: Castle Peak Hospital, Hong Kong Special Administrative Region, China.
authors.forename: Eric F C
authors.initials: EF
authors.lastname: Cheung
authors.affiliation: Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China. Electronic address: rckchan@psych.ac.cn.
authors.forename: Raymond C K
authors.initials: RC
authors.lastname: Chan
mesh_terms: D000293:Adolescent; D000679:Amygdala / Q000503:physiopathology; D059445:Anhedonia; D059031:Anticipation, Psychological; D001921:Brain / Q000503:physiopathology*; D016022:Case-Control Studies; D005260:Female; D059907:Functional Neuroimaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009010:Monte Carlo Method; D009042:Motivation; D017397:Prefrontal Cortex / Q000503:physiopathology; D011699:Putamen / Q000503:physiopathology; D012201:Reward; D012569:Schizotypal Personality Disorder / Q000503:physiopathology*; D066328:Ventral Striatum / Q000503:physiopathology; D055815:Young Adult
keywords: Negative schizotypy; Positive schizotypy; Reward anticipation; Reward consummation; fMRI