title: [STUDYING SOME PHARMACOLOGICAL EFFECTS OF NEW 3-HYDROXYPYRIDINE DERIVATIVE].
abstract: It was established that a new 3-hydroxypyridine (3-HP) derivative, 2-ethyl-6-methyl-3-hydroxypyridine L-aspartate (3-HP), in small doses (1 and 5 mg/kg) increased physical performance in treadmill and swimming tests on rats. The new substance showed greater or equal effects compared to the reference actoprotector drugs metaprot and ladasten in much higher doses. The gluconeogenesis inhibitor tryptophan significantly (74 ± 5%, p < 0.01) prevented this stimulatory effect of 3-HPA in the treadmill test on rats. 3-HPA at a higher dose (30 mg/kg) had marked antiamnesic effect on various models of amnesia in mice. It was more effective than reference drugs mexidol (another 3-HP derivative) in a dose of 30 mg/kg and nootropic drug piracetam in a dose of 200 mg/kg, but had equal effect with these drugs in doses of 50 and 800 mg/kg, respectively. 3-HPA (30 mg/kg per day) had neuroprotective effect in rats with brain ischemia and decreased the neurologic deficiency more effectively than mexidol (50 mg/kg per day).
authors.forename: V V
authors.initials: VV
authors.lastname: Yasnetsov
authors.forename: E G
authors.initials: EG
authors.lastname: Tsublova
authors.forename: Vic V
authors.initials: VV
authors.lastname: Yasnetsov
authors.forename: S Ya
authors.initials: SY
authors.lastname: Skachilova
authors.forename: S K
authors.initials: SK
authors.lastname: Karsanova
authors.forename: Yu V
authors.initials: YV
authors.lastname: Ivanov
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives / Q000494:pharmacology; D000647:Amnesia / Q000188:drug therapy* / Q000503:physiopathology; D000818:Animals; D021461:Animals, Outbred Strains; D000927:Anticonvulsants / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology; D002545:Brain Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D004195:Disease Models, Animal; D005080:Exercise Test; D005943:Gluconeogenesis / Q000187:drug effects; D008297:Male; D051379:Mice; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018697:Nootropic Agents / Q000494:pharmacology*; D010805:Physical Conditioning, Animal; D010847:Picolines / Q000494:pharmacology*; D010889:Piracetam / Q000494:pharmacology; D051381:Rats; D013550:Swimming; D014364:Tryptophan / Q000494:pharmacology
chemical_list: D000927:Anticonvulsants; D001562:Benzimidazoles; C493151:N-(2-adamantyl)-N-p-bromophenylamine; D018696:Neuroprotective Agents; D018697:Nootropic Agents; D010847:Picolines; C070020:emoxypine succinate; C049825:bemethyl; D014364:Tryptophan; D000218:Adamantane; C009820:6-methyl-2-ethyl-3-hydroxypyridine; D010889:Piracetam