title: Trisomy 12 is a Rare Event in Cases of CLL with Typical Immunophenotype and Morphology.
abstract: 131 patients with lymphoproliferative disorders were classified as having typical Chromic Lymphocytic Leukaemia [CLL], atypical CLL, Chromic Lymphocytic Leukaemia/Prolymphocytic Leukaemia [CLL/PL] or Non-Hodgkin's Lymphoma [NHL] using immunophenotyping and morphology. The incidence of trisomy 12 (+12) in each of the groups was ascertained using fluorescent in situ hybridization. Trisomy 12 was found to be rare in the typical CLL group (<3%) and more common in the atypical CLL (22%), CLL/PL (40%) and NHL (43%) categories. The low incidence of +12 in the typical CLL group is most likely due to our adherence to strict inclusion criteria to ensure other similar lymphoproliferative disorders, with a high incidence of +12, were excluded. This approach leads to more homogeneous disease categories and consequently may help to resolve issues such as the impact on survival of +12 in CLL.
authors.affiliation: a Department of Haematology , Taunton and Somerset Hospital , Musgrove Park, Taunton TA1 5DA , Somerset , UK.
authors.forename: D J
authors.initials: DJ
authors.lastname: Howe
authors.affiliation: a Department of Haematology , Taunton and Somerset Hospital , Musgrove Park, Taunton TA1 5DA , Somerset , UK.
authors.forename: T J
authors.initials: TJ
authors.lastname: Bromidge
authors.affiliation: a Department of Haematology , Taunton and Somerset Hospital , Musgrove Park, Taunton TA1 5DA , Somerset , UK.
authors.forename: M
authors.initials: M
authors.lastname: Stack-Dunne
authors.affiliation: a Department of Haematology , Taunton and Somerset Hospital , Musgrove Park, Taunton TA1 5DA , Somerset , UK.
authors.forename: S V
authors.initials: SV
authors.lastname: Davies
authors.affiliation: a Department of Haematology , Taunton and Somerset Hospital , Musgrove Park, Taunton TA1 5DA , Somerset , UK.
authors.forename: A
authors.initials: A
authors.lastname: Paxton
authors.affiliation: a Department of Haematology , Taunton and Somerset Hospital , Musgrove Park, Taunton TA1 5DA , Somerset , UK.
authors.forename: M J
authors.initials: MJ
authors.lastname: Phillips
authors.affiliation: a Department of Haematology , Taunton and Somerset Hospital , Musgrove Park, Taunton TA1 5DA , Somerset , UK.
authors.forename: S J
authors.initials: SJ
authors.lastname: Rule
authors.affiliation: a Department of Haematology , Taunton and Somerset Hospital , Musgrove Park, Taunton TA1 5DA , Somerset , UK.
authors.forename: S A
authors.initials: SA
authors.lastname: Johnson
keywords: CLL; Trisomy 12; immunophenotype; morphology