title: In myotonic dystrophy type 1 reduced FDG-uptake on FDG-PET is most severe in Brodmann area 8.
abstract: BACKGROUND
  In myotonic dystrophy type 1 (DM1), only one FDG-PET study used statistical parametric mapping (SPM) showing frontal reduced FDG-uptake. Our aim was to 1) identify the FDG-PET area with the most severe reduced FDG-uptake using SPM8 in a larger group of patients 2) assess potential correlation between CTG-numbers and FDG-PET.
  
  
  METHODS
  FDG-PET was performed in 24 patients and compared to 24 controls. Pearson's correlation was used to analyse correlation.
  
  
  RESULTS
  SPM8 revealed Brodmann area 8 as the area with the most severe reduced FDG-uptake. Weak, although not statistically significant, correlation was observed between CTG-numbers and reduced FDG-uptake in Brodmann area 8.
  
  
  CONCLUSIONS
  In DM1, Brodmann area 8 is the area with the most severe reduced FDG-uptake on FDG-PET. Brodmann area 8 reduced FDG-uptake is correlated -although weakly- to CTG-repeat numbers.
authors.affiliation: Department of Neurology, CHU Nîmes, Hôpital Caremeau, Place du Pr Debré, 30029, Nîmes Cedex 4, France. dimitrirenard@hotmail.com.
authors.forename: Dimitri
authors.initials: D
authors.lastname: Renard
authors.affiliation: Department of Nuclear Medicine, CHU Nîmes, Hôpital Caremeau, Place du Pr Debré, 30029, Nîmes Cedex 4, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Collombier
authors.affiliation: Laboratoire de Biostatistique, Epidémiologie clinique, Santé Publique et Information, Médicale (BESPIM), CHU Nîmes, Hôpital Caremeau, Place du Pr Debré, 30029, Nîmes Cedex 4, France.
authors.forename: Christel
authors.initials: C
authors.lastname: Castelli
authors.affiliation: Department of Nuclear Medicine, CHU Nîmes, Hôpital Caremeau, Place du Pr Debré, 30029, Nîmes Cedex 4, France.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Pouget
authors.affiliation: Department of Nuclear Medicine, CHU Nîmes, Hôpital Caremeau, Place du Pr Debré, 30029, Nîmes Cedex 4, France.
authors.forename: Pierre-Olivier
authors.initials: PO
authors.lastname: Kotzki
authors.affiliation: Department of Nuclear Medicine, CHU Nîmes, Hôpital Caremeau, Place du Pr Debré, 30029, Nîmes Cedex 4, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Boudousq
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009223:Myotonic Dystrophy / Q000503:physiopathology*; D049268:Positron-Emission Tomography / Q000379:methods*