title: Two New Phenanthrene Glucosides from Cremastra appendiculata and their Cytotoxic Activities.
abstract: Two new phenanthrene glucosides, named 2'-hydroxy-4,4',7'-trimethoxy-1, l'-biphenanthrene-2,7-di-O-β-D-glucoside (1) and 1-(4-hydroxybenzyl)-4-methoxy-2,7-dihydroxy-phenanthrene-8-O-β-D-glucoside (2), together with three known compounds were isolated from the tubers of Cremastra appendiculata (D.Don) Makino. Their structures were elucidated on the basis of spectral data. Compounds 1-4 showed moderate cytotoxic activity and compound 5 showed weak cytotoxic activity against the two cell lines tested. This is the first reported occurrence of an unusual biphenanthrene glucoside in this plant.
authors.forename: Xin-Qiao
authors.initials: XQ
authors.lastname: Liu
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Li
authors.forename: Wen-Ke
authors.initials: WK
authors.lastname: Yuan
authors.forename: Qiao-Yu
authors.initials: QY
authors.lastname: Yuan
authors.forename: Bin-Hua
authors.initials: BH
authors.lastname: Qin
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification*; D006801:Humans; D029595:Orchidaceae / Q000737:chemistry*; D010616:Phenanthrenes / Q000737:chemistry / Q000302:isolation & purification*; D035281:Plant Tubers / Q000737:chemistry
chemical_list: C000611027:1-(4-hydroxybenzyl)-4-methoxy-2,7-dihydroxy-phenanthrene-8-O-beta-D-glucoside; C000611026:2'-hydroxy-4,4',7'-trimethoxy-1,l'-biphenanthrene-2,7-di-O-beta-D-glucoside; D000972:Antineoplastic Agents, Phytogenic; D005960:Glucosides; D010616:Phenanthrenes