title: Recurrent trichosporonosis with central nervous system involvement in an allogeneic hematopoietic stem cell transplant recipient.
abstract: Trichosporon is an ubiquitous yeast that has emerged as an opportunistic pathogen in the immunocompromised host. We describe a case of invasive trichosporonosis in an allogeneic hematopoietic stem cell transplant (allo-HSCT) recipient while on caspofungin antifungal prophylaxis. She developed disseminated trichosporonosis in the pre-engraftment period and was successfully treated with voriconazole. She later developed 2 further episodes of invasive trichosporonosis involving the central nervous system. This case highlights the challenges of managing trichosporonosis in allo-HSCT recipients and suggests the need for lifelong therapy in some patients.
authors.affiliation: Department of Infectious Diseases, Singapore General Hospital, Singapore.
authors.forename: S Y
authors.initials: SY
authors.lastname: Thien
authors.affiliation: Department of Infectious Diseases, Singapore General Hospital, Singapore.
authors.forename: S J
authors.initials: SJ
authors.lastname: Chung
authors.affiliation: Department of Pathology, Singapore General Hospital, Singapore.
authors.forename: A L
authors.initials: AL
authors.lastname: Tan
authors.affiliation: Department of Hematology, Singapore General Hospital, Singapore.
authors.forename: W Y K
authors.initials: WY
authors.lastname: Hwang
authors.affiliation: Department of Infectious Diseases, Singapore General Hospital, Singapore.
authors.forename: B H
authors.initials: BH
authors.lastname: Tan
authors.affiliation: Department of Infectious Diseases, Singapore General Hospital, Singapore. tan.thuan.tong@singhealth.com.sg.
authors.forename: T T
authors.initials: TT
authors.lastname: Tan
mesh_terms: D000741:Anemia, Aplastic / Q000628:therapy*; D019072:Antibiotic Prophylaxis / Q000379:methods*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000077336:Caspofungin; D002490:Central Nervous System / Q000000981:diagnostic imaging / Q000382:microbiology*; D054714:Echinocandins / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology / Q000601:surgery; D016867:Immunocompromised Host; D007165:Immunosuppression Therapy / Q000009:adverse effects; D007796:Laminectomy; D055666:Lipopeptides / Q000008:administration & dosage / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D009894:Opportunistic Infections / Q000134:cerebrospinal fluid / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D012008:Recurrence; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D014230:Triazoles / Q000008:administration & dosage / Q000627:therapeutic use; D014250:Trichosporon / Q000302:isolation & purification*; D060586:Trichosporonosis / Q000134:cerebrospinal fluid / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D017287:Ventriculoperitoneal Shunt; D065819:Voriconazole / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D014230:Triazoles; C101425:posaconazole; D000077336:Caspofungin; D065819:Voriconazole
keywords: 
  Trichosporon asahii
  ; aplastic anemia; central nervous system infection; hematopoietic stem cell transplant; hydrocephalus; trichosporonosis