title: Serum levels of resistin and interleukin-17 are associated with increased cartilage defects and bone marrow lesions in patients with knee osteoarthritis.
abstract: OBJECTIVE
  To investigate cross-sectional associations between serum levels of resistin and interleukin-17 (IL-17) and cartilage defects and bone marrow lesions (BMLs) in patients with knee symptomatic osteoarthritis (OA).
  
  
  METHODS
  One hundred and ninety-four consecutively-selected patients with knee symptomatic OA (mean 55.4 years, range 34-74, 87% females) were included in Anhui Osteoarthritis (AHOA) Study. Knee cartilage defects and BMLs were determined at different sites using T2-weighted fat-suppressed fast spin echo MRI. Serum resistin, IL-17, and high-sensitivity C-reactive protein (hs-CRP) levels were measured using ELISA.
  
  
  RESULTS
  In multivariable analyses, serum resistin was positively associated with cartilage defects at lateral femoral, lateral tibial, and medial tibial (all p < 0.05) sites. The significant associations were also present with BMLs at lateral femoral and tibial sites (ORs: 1.13-1.19, both p < 0.05). In patients with the highest quartile of hs-CRP (>2.45 pg/ml), IL-17 was positively and significantly associated with cartilage defect score at nearly all sites (ORs: 1.33-1.44, all p < 0.05), and BMLs at lateral and medial femoral sites (ORs: 1.26-1.51, both p < 0.05).
  
  
  CONCLUSIONS
  Serum levels of resistin were positively and independently associated with cartilage defects and BMLs in patients with knee OA. Serum IL-17 was significantly associated with cartilage defects and BMLs in patients with an increased inflammatory status. These suggest that metabolic and inflammatory mechanisms may have a role to play in knee OA.
authors.affiliation: a Department of Rheumatology and Immunology , Arthritis Research Institute, the First Affiliated Hospital of Anhui Medical University , Hefei , China and.|b Menzies Institute for Medical Research, University of Tasmania , Hobart , Tasmania , Australia.
authors.forename: Kang
authors.initials: K
authors.lastname: Wang
authors.affiliation: a Department of Rheumatology and Immunology , Arthritis Research Institute, the First Affiliated Hospital of Anhui Medical University , Hefei , China and.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Xu
authors.affiliation: a Department of Rheumatology and Immunology , Arthritis Research Institute, the First Affiliated Hospital of Anhui Medical University , Hefei , China and.
authors.forename: Jingyu
authors.initials: J
authors.lastname: Cai
authors.affiliation: a Department of Rheumatology and Immunology , Arthritis Research Institute, the First Affiliated Hospital of Anhui Medical University , Hefei , China and.|b Menzies Institute for Medical Research, University of Tasmania , Hobart , Tasmania , Australia.
authors.forename: Shuang
authors.initials: S
authors.lastname: Zheng
authors.affiliation: a Department of Rheumatology and Immunology , Arthritis Research Institute, the First Affiliated Hospital of Anhui Medical University , Hefei , China and.
authors.forename: Xueqing
authors.initials: X
authors.lastname: Yang
authors.affiliation: a Department of Rheumatology and Immunology , Arthritis Research Institute, the First Affiliated Hospital of Anhui Medical University , Hefei , China and.|b Menzies Institute for Medical Research, University of Tasmania , Hobart , Tasmania , Australia.
authors.forename: Changhai
authors.initials: C
authors.lastname: Ding
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D001853:Bone Marrow / Q000473:pathology*; D002358:Cartilage, Articular / Q000473:pathology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000097:blood* / Q000473:pathology; D052243:Resistin / Q000097:blood*
chemical_list: D015415:Biomarkers; C508717:IL17A protein, human; D020381:Interleukin-17; D052243:Resistin
keywords: Bone; Cartilage; Interleukin-17; Osteoarthritis; Resistin