title: Ruthenium-Catalyzed Direct and Selective C-H Cyanation of N-(Hetero)aryl-7-azaindoles.
abstract: An efficient, highly regioselective, and scalable ruthenium-catalyzed o-aryl C-H mono-cyanation of N-aryl-7-azaindoles to form N-(2-cyanoaryl)-7-azaindoles has been developed through N-directed ortho C-H activation using N-cyano-N-phenyl-p-toluenesulfonamide as cyanating reagent in the presence of AgOTf and NaOAc in DCE. A range of substrates has furnished cyanated azaindoles in good to excellent yields under the simple reaction conditions. Involvement of C-H metalation has been supported by a kinetic study. This methodology provides easy access to a class of pharmaceutically significant molecules and their precursors.
authors.affiliation: Organic and Medicinal Chemistry Division, Indian Institute of Chemical Biology , 4-Raja S. C. Mullick Road, Jadavpur, Kolkata 700032, India.
authors.forename: Aniket
authors.initials: A
authors.lastname: Mishra
authors.affiliation: Organic and Medicinal Chemistry Division, Indian Institute of Chemical Biology , 4-Raja S. C. Mullick Road, Jadavpur, Kolkata 700032, India.
authors.forename: Tripta Kumari
authors.initials: TK
authors.lastname: Vats
authors.affiliation: Organic and Medicinal Chemistry Division, Indian Institute of Chemical Biology , 4-Raja S. C. Mullick Road, Jadavpur, Kolkata 700032, India.
authors.forename: Indubhusan
authors.initials: I
authors.lastname: Deb