title: [Fibroblast growth factor 23 in chronic kidney disease in children].
abstract: Cardiovascular risk in children with chronic kidney disease (CKD) is many times higher compared to their healthy peers, and discovered in year 2000 fibroblast growth factor 23 (FGF23) may be one of the factors responsible. FGF23 together with its cofactor, α-Klotho protein, plays a pivotal role in calcium-phosphorus metabolism in patients with CKD by decreasing secretion of active metabolite of vitamin D and antagonizing phosphate resorption in renal tubules. Studies conducted in recent years revealed that FGF23 directly binds to its receptor on cardiomyocytes and promotes left ventricular hypertrophy. Clinical trials in children with CKD, similarly to adult studies, suggest a key role of this protein in development of calciumphosphorus disturbances. Single studies in small patient groups suggest also a significance of FGF23 in pathogenesis of cardiovascular alterations in this population. Further clinical trials investigating role of FGF23 in development of cardiovascular damage in larger groups of children are necessary, which may open new therapeutic options for these patients in future.
authors.affiliation: Medical University of Warsaw, Poland: Department of Pediatrics with Observational Ward.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Okarska-Napierała
authors.affiliation: Medical University of Warsaw, Poland: Department of Pediatrics and Nephrology.
authors.forename: Piotr
authors.initials: P
authors.lastname: Skrzypczyk
authors.affiliation: Medical University of Warsaw, Poland: Department of Pediatrics and Nephrology.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Pańczyk-Tomaszewska
mesh_terms: D002318:Cardiovascular Diseases / Q000209:etiology* / Q000378:metabolism; D002648:Child; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000502:physiology*; D005966:Glucuronidase / Q000502:physiology; D006801:Humans; D000090265:Klotho Proteins; D032383:Myocytes, Cardiac / Q000378:metabolism; D051436:Renal Insufficiency, Chronic / Q000209:etiology* / Q000378:metabolism; D012307:Risk Factors
chemical_list: C000717427:FGF23 protein, human; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D005966:Glucuronidase; D000090265:Klotho Proteins
keywords: cardiovascular risk; children; chronic kidney disease; fibroblast growth factor 23