title: Technetium-99m Sestamibi Scanning Reflects Marrow Activity in a β-Thalassemia Patient Treated with an Allogeneic Bone Marrow Transplant.
abstract: β-thalassemia major is a disorder of globin synthesis, resulting in anemia and compensatory bone marrow hyperproliferation. Conventional imaging studies do not measure bone marrow activity reliably. We report on the use of technetium-99m sestamibi (MIBI) in a β-thalassemia major patient treated with an allogeneic bone marrow transplant. Pre-transplant and early post-transplant MIBI scannings demonstrated generalized marrow uptake, reflecting marrow hyperproliferation. After full engraftment, post-transplant MIBI showed disappearance of abnormal uptake in the skeleton, indicating normalization of the marrow activity. MIBI scan may be used as a noninvasive measure of bone marrow proliferation that may guide hypertransfusion therapy in thalassemia patients.
authors.affiliation: a Stem Cell Transplantation Program, Division of Hematology/Oncology, Department of Medicine , Cedars-Sinai Medical Center , Los Angeles , California , USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Look
authors.affiliation: a Stem Cell Transplantation Program, Division of Hematology/Oncology, Department of Medicine , Cedars-Sinai Medical Center , Los Angeles , California , USA.
authors.forename: H A
authors.initials: HA
authors.lastname: Koh
authors.affiliation: a Stem Cell Transplantation Program, Division of Hematology/Oncology, Department of Medicine , Cedars-Sinai Medical Center , Los Angeles , California , USA.
authors.forename: S I
authors.initials: SI
authors.lastname: Hamburg
authors.affiliation: a Stem Cell Transplantation Program, Division of Hematology/Oncology, Department of Medicine , Cedars-Sinai Medical Center , Los Angeles , California , USA.
authors.forename: S W
authors.initials: SW
authors.lastname: Lim
authors.affiliation: b Department of Nuclear Medicine , Cedars-Sinai Medical Center , Los Angeles , California , USA.
authors.forename: A D
authors.initials: AD
authors.lastname: Waxman
authors.affiliation: c Department of Imaging Services , Cedars-Sinai Medical Center , Los Angeles , California , USA.
authors.forename: M S
authors.initials: MS
authors.lastname: Jochelson
authors.affiliation: b Department of Nuclear Medicine , Cedars-Sinai Medical Center , Los Angeles , California , USA.
authors.forename: P K
authors.initials: PK
authors.lastname: Gupta
authors.affiliation: a Stem Cell Transplantation Program, Division of Hematology/Oncology, Department of Medicine , Cedars-Sinai Medical Center , Los Angeles , California , USA.
authors.forename: M M
authors.initials: MM
authors.lastname: Fuerst
authors.affiliation: a Stem Cell Transplantation Program, Division of Hematology/Oncology, Department of Medicine , Cedars-Sinai Medical Center , Los Angeles , California , USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Kusuanco
authors.affiliation: a Stem Cell Transplantation Program, Division of Hematology/Oncology, Department of Medicine , Cedars-Sinai Medical Center , Los Angeles , California , USA.
authors.forename: G N
authors.initials: GN
authors.lastname: Lawrence
authors.affiliation: a Stem Cell Transplantation Program, Division of Hematology/Oncology, Department of Medicine , Cedars-Sinai Medical Center , Los Angeles , California , USA.
authors.forename: F J
authors.initials: FJ
authors.lastname: Giles
keywords: MIBI scan; allogeneic bone marrow transplant; bone marrow activity; erythropoiesis; hypertransfusion; β-thalassemia major