title: Impact of Body Mass Index on Left Ventricular Function.
abstract: BACKGROUND
  Obesity is associated with increased cardiovascular morbidity and mortality. A direct effect of isolated obesity on cardiac function is not well established. The study was designed to determine the direct effect of various grades of isolated obesity on echocardiographic indices of systolic and diastolic left ventricular function.
  
  
  METHODS
  Fifty one obese and 25 normal weight, serving personnel without any other pathological condition were studied. Group I (n=25) consisted of subjects with normal weight and body mass index (BMI <25kg/m(2)), Group II (n=34) of overweight subjects (BMI 25-29.9 kg/m(2)) and Group III (n=17) of obese subjects (BMI >30 kg/m(2)). Echocardiographic indices of systolic and diastolic function were obtained and dysfunction was assumed when at least two values differed by ≥ 2 SD from the normal weight group.
  
  
  RESULTS
  Ejection fraction, fractional shortening were increased (p<0.05) in Group II and III. Left ventricular dimensions were increased (p< 0.001) but relative wall thickness was unchanged. Systolic dysfunction was not observed in any of the obese patients. The mitral valve pressure half time (p< 0.01), left atrial diameter (p < 0.01) and the deceleration time were increased (p< 0.01) in obese subjects, while other diastolic variables were unchanged. No difference were found between obesity subgroups. Subclinical diastolic dysfunction was more prevalent among obese subjects. BMI correlated significantly with indices of left ventricular systolic and diastolic function.
  
  
  CONCLUSIONS
  Subclinical left ventricular diastolic dysfunction was noted in all grades of obesity which correlates with BMI.
authors.affiliation: Classified Specialist (Cardiology), Command Hospital (AF), Bangalore.
authors.forename: D S
authors.initials: DS
authors.lastname: Chadha
authors.affiliation: Classified Specialist (Cardiology), Command Hospital (AF), Bangalore.
authors.forename: A
authors.initials: A
authors.lastname: Swamy
authors.affiliation: Senior Advisor, (Cardiology), Command Hospital (EC), Kolkata.
authors.forename: S K
authors.initials: SK
authors.lastname: Malani
authors.affiliation: Ex-Commandant, Command Hospital (AF), Bangalore.
authors.forename: R K
authors.initials: RK
authors.lastname: Ganjoo
authors.affiliation: Commandant, Army Hosp (R&R), Delhi Cantt.
authors.forename: O P
authors.initials: OP
authors.lastname: Mathew
keywords: Diastolic function; Echocardiography; Obesity; Systolic function