title: Urethral dose sparing in squamous cell carcinoma of anal canal using proton therapy matching electrons with prior brachytherapy for prostate cancer: A case study.
abstract: The purpose of this case study is to communicate a technique on treating the re-irradiation of squamous cell carcinoma (SCC) of anal canal with proton fields matched with electron fields to spare prostatic urethra. A 76-year old male presented with a secondary radiation-induced malignancy as a result of prostate brachytherapy seeds irradiation 10 years prior. A rectal examination revealed a bulky tumor at the top of the anal canal involving the left superior-most aspect of the anal canal extending superiorly into the rectum. The inferior extent was palpable approximately 3cm from the anal verge and the superior extent of the mass measured greater than 5cm in the superior-inferior dimension. Chemoradiation was suggested since the patient was opposed to abdominoperineal resection (APR) and colostomy. The use of proton therapy matching with electron fields in the re-irradiation setting could help reduce the complications. A 2 lateral proton beams were designed to treat the bulky tumor volume with 2 electron beams treating the nodal volumes. This complication of treatment fields helped spare the prostatic urethra and reduced the risk of urinary obstruction in the future.
authors.affiliation: Medical Dosimetry Graduate Program, University of Wisconsin, La Crosse, WI; Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA. Electronic address: ontida.a@gmail.com.
authors.forename: Ontida
authors.initials: O
authors.lastname: Apinorasethkul
authors.affiliation: Medical Dosimetry Graduate Program, University of Wisconsin, La Crosse, WI.
authors.forename: Nishele
authors.initials: N
authors.lastname: Lenards
authors.affiliation: Medical Dosimetry Graduate Program, University of Wisconsin, La Crosse, WI.
authors.forename: Ashley
authors.initials: A
authors.lastname: Hunzeker
mesh_terms: D000368:Aged; D001005:Anus Neoplasms / Q000532:radiotherapy*; D001918:Brachytherapy / Q000379:methods*; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy*; D004583:Electrons / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D061766:Proton Therapy; D011880:Radiotherapy Planning, Computer-Assisted; D014057:Tomography, X-Ray Computed; D047368:Tumor Burden; D014521:Urethra / Q000528:radiation effects*
keywords: Anal cancer; Proton therapy; Re-irradiation; Urethral sparing