title: [Vaginal Follicular dendritic cell sarcoma in patient with previous urinary tract carcinoma. Case Report].
abstract: BACKGROUND
  follicular dendritic cell sarcoma (FDC sarcoma) is an uncommon neoplasm derived from FDC present in lymphoid follicles. It usually presents in lymph nodes, being extranodal location a very unusual event.
  
  
  METHODS
  A 78 year old female, with prior left nephrectomy for invasive urothelial carcinoma, consulted for genitorragia. At examination, a polypoid vaginal lesion, measuring 3.5 cm in diameter was discovered. It was reported as squamous cell carcinoma in incisional biopsy. A polipectomy was performed. Examination of resected specimen showed a tumor having pushing edges, arranged in a solid pattern with spindle and epithelioid cells, having a syncytial appearance, diffusely sprinkled with numerous lymphocytes and granulocytes. At immunohistochemistry neoplastic cells were positive for vimentin, CD 68, CD 21 and fascine, and focally positive for S-100 and CD45. Occasional scattered neoplastic cells expressed CD30 and CD 23. They were negative for CD3, CD20, myeloperoxidase, AE1 / AE3, EMA, HMB45, Melan A, desmin, Chromogranin, CD1a and CD35. Infiltrating lymphocites were mainly of T cell lineage (CD3 +).
  
  
  CONCLUSIONS
  We report a case of FDC sarcoma in an unusual location, being to our knowledge, the first one at this site. The fact of having a prior neoplasia posed additional difficulties in differential diagnosis. Histological findings with expression of a specific marker of FDC (in this case CD21) allowed us to establish an accurate diagnosis.
authors.affiliation: Servicio de Anatomía Patológica Hospital Rawson. Cátedra de Anatomía Patológica y Fisiopatología, Facultad de Medicina, Universidad Católica de Córdoba.
authors.forename: Alejandro Martin
authors.initials: AM
authors.lastname: Zaya
authors.affiliation: Servicio de Anatomía Patológica Hospital Rawson. Cátedra de Anatomía Patológica y Fisiopatología, Facultad de Medicina, Universidad Católica de Córdoba.
authors.forename: Ana Carolina
authors.initials: AC
authors.lastname: González
authors.affiliation: Biología Celular, Histología y Embriología, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba.
authors.forename: Silvana S
authors.initials: SS
authors.lastname: Sandrone
authors.affiliation: Cátedra de Anatomía Patológica y Fisiopatología, Facultad de Medicina, Universidad Católica de Córdoba.-
authors.forename: Ruben Horacio
authors.initials: RH
authors.lastname: Sambuelli
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D054740:Dendritic Cell Sarcoma, Follicular / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000601:surgery; D014571:Urologic Neoplasms / Q000473:pathology* / Q000601:surgery; D014625:Vaginal Neoplasms / Q000473:pathology* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor