title: The L-amino acid oxidase from Calloselasma rhodostoma snake venom modulates apoptomiRs expression in Bcr-Abl-positive cell lines.
abstract: Anti-apoptotic genes and apoptomiRs deregulated expression contribute to apoptosis resistance in chronic myeloid leukemia (CML) Bcr-Abl(+) cells. Here, the L-amino acid oxidase from Calloselasma rhodostoma (CR-LAAO) venom altered the apoptotic machinery regulation by modulating the expression of the miR-145, miR-26a, miR-142-3p, miR-21, miR-130a, and miR-146a, and of the apoptosis-related proteins Bid, Bim, Bcl-2, Ciap-2, c-Flip, and Mcl-1 in Bcr-Abl(+) cells. CR-LAAO is a potential tool to instigate apoptomiRs regulation that contributes to drive CML therapy.
authors.affiliation: Department of Clinical Analysis, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo - USP, Ribeirão Preto, SP, Brazil. Electronic address: sandra_burin@yahoo.com.br.
authors.forename: Sandra Mara
authors.initials: SM
authors.lastname: Burin
authors.affiliation: Department of Clinical Analysis, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo - USP, Ribeirão Preto, SP, Brazil. Electronic address: gabrielaberzoti@usp.br.
authors.forename: Maria Gabriela
authors.initials: MG
authors.lastname: Berzoti-Coelho
authors.affiliation: Department of Clinical Analysis, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo - USP, Ribeirão Preto, SP, Brazil. Electronic address: jucara.cominal@gmail.com.
authors.forename: Juçara Gastaldi
authors.initials: JG
authors.lastname: Cominal
authors.affiliation: Department of Clinical Analysis, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo - USP, Ribeirão Preto, SP, Brazil. Electronic address: ambrosio@fcfrp.usp.br.
authors.forename: Luciana
authors.initials: L
authors.lastname: Ambrosio
authors.affiliation: Department of Clinical Analysis, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo - USP, Ribeirão Preto, SP, Brazil. Electronic address: torqueti@fcfrp.usp.br.
authors.forename: Maria Regina
authors.initials: MR
authors.lastname: Torqueti
authors.affiliation: Department of Clinical Analysis, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo - USP, Ribeirão Preto, SP, Brazil. Electronic address: suvilela@usp.br.
authors.forename: Suely Vilela
authors.initials: SV
authors.lastname: Sampaio
authors.affiliation: Department of Clinical Analysis, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo - USP, Ribeirão Preto, SP, Brazil. Electronic address: castrofa@fcfrp.usp.br.
authors.forename: Fabíola Attié
authors.initials: FA
authors.lastname: de Castro
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects* / Q000235:genetics; D045744:Cell Line, Tumor; D003435:Crotalid Venoms / Q000201:enzymology*; D016313:Genes, abl; D057809:HEK293 Cells; D006801:Humans; D050830:L-Amino Acid Oxidase / Q000378:metabolism* / Q000494:pharmacology; D035683:MicroRNAs / Q000187:drug effects* / Q000235:genetics; D017819:Viperidae
chemical_list: D003435:Crotalid Venoms; D035683:MicroRNAs; D050830:L-Amino Acid Oxidase
keywords: Apoptosis; Bcr-Abl; Calloselasma rhodostoma; Chronic myeloid leukemia; L-amino acid oxidase; MicroRNAs