title: A Bullous Flare of a Hyperkeratotic Affair: A Case Report.
abstract: BACKGROUND
  Darier's disease is an autosomal dominant genodermatosis typified by hyperkeratotic papules and plaques in a predominately seborrheic distribution. The vesiculo-bullous variant of Darier's disease is rare. Several previously reported cases have demonstrated clinical and microscopic features resembling familial benign chronic pemphigus or Hailey-Hailey disease.
  
  
  OBJECTIVE
  The objective of this report is to describe an uncommon presentation of Darier's disease, which has been infrequently described in the literature.
  
  
  METHODS
  The authors present a case of bullous flare of long-standing Darier's disease.
  
  
  CONCLUSIONS
  Darier's disease may assume several atypical morphologies, including vesiculo-bullous lesions.
authors.affiliation: Department of Dermatology, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
authors.forename: Natasha
authors.initials: N
authors.lastname: Klimas
authors.affiliation: Department of Dermatology, Texas Tech University Health Sciences Center, Lubbock, TX, USA cameron.westmd@gmail.com.
authors.forename: Cameron
authors.initials: C
authors.lastname: West
authors.affiliation: Department of Dermatology, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
authors.forename: Michelle
authors.initials: M
authors.lastname: Tarbox
mesh_terms: D017255:Acitretin / Q000627:therapeutic use; D001768:Blister / Q000209:etiology; D007644:Darier Disease / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D007645:Keratoderma, Palmoplantar / Q000209:etiology; D007641:Keratolytic Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D000067251:Symptom Flare Up
chemical_list: D007641:Keratolytic Agents; D017255:Acitretin
keywords: Darier’s disease; bullous disorder; keratosis follicularis