title: WT1 Mutation in Childhood Cancer.
abstract: In this chapter, the role of WT1 in childhood cancer is discussed, using the key examples Wilms' tumor, desmoplastic small round cell of childhood, and leukemia. The role of WT1 in each disease is described and mirrored to the role of WT1 in normal development.
authors.affiliation: UCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.
authors.forename: Jocelyn
authors.initials: J
authors.lastname: Charlton
authors.affiliation: UCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK. k.pritchard-jones@ucl.ac.uk.|Hugh and Catherine Stevenson Professor of Paediatric Oncology, UCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK. k.pritchard-jones@ucl.ac.uk.
authors.forename: Kathy
authors.initials: K
authors.lastname: Pritchard-Jones
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D058405:Desmoplastic Small Round Cell Tumor / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007668:Kidney / Q000254:growth & development; D007938:Leukemia / Q000235:genetics*; D009154:Mutation; D025721:WT1 Proteins / Q000235:genetics*; D009396:Wilms Tumor / Q000235:genetics*
chemical_list: D025721:WT1 Proteins; C583751:WT1 protein, human
keywords: Childhood cancer; Desmoplastic small round cell tumor of childhood; Development; Leukemia; Minimal residual disease; Wilms’ tumor