title: Nanostructured luminescently labeled nucleic acids.
abstract: Important and emerging trends at the interface of luminescence, nucleic acids and nanotechnology are: (i) the conventional luminescence labeling of nucleic acid nanostructures (e.g. DNA tetrahedron); (ii) the labeling of bulk nucleic acids (e.g. single-stranded DNA, double-stranded DNA) with nanostructured luminescent labels (e.g. copper nanoclusters); and (iii) the labeling of nucleic acid nanostructures (e.g. origami DNA) with nanostructured luminescent labels (e.g. silver nanoclusters). This review surveys recent advances in these three different approaches to the generation of nanostructured luminescently labeled nucleic acids, and includes both direct and indirect labeling methods.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, Pennsylvania, 19104, USA.
authors.forename: Larry J
authors.initials: LJ
authors.lastname: Kricka
authors.affiliation: Department of Cancer Biology, Cancer Genomics Laboratory, Sidney Kimmel Cancer Center, Thomas Jefferson University Jefferson Medical College, Philadelphia, PA, USA.|Department of Molecular Medicine, Universita' La Sapienza, Rome, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Fortina
authors.affiliation: Department of Pathology and the Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas, 75229, USA.
authors.forename: Jason Y
authors.initials: JY
authors.lastname: Park
mesh_terms: D049449:Luminescence; D049329:Nanostructures / Q000737:chemistry*; D009696:Nucleic Acids / Q000737:chemistry*
chemical_list: D009696:Nucleic Acids
keywords: chemiluminescence; electrochemiluminescence; nanostructures; nucleic acid labeling; photoluminescence