title: Metronidazole Metabolism in Neonates and the Interplay Between Ontogeny and Genetic Variation.
authors.affiliation: Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA.
authors.forename: Laura A
authors.initials: LA
authors.lastname: Wang
authors.affiliation: Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Gonzalez
authors.affiliation: Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA.|Department of Pharmacology, University of Missouri-Kansas City School of Pharmacy, Kansas City, MO, USA.|Divisions of Clinical Pharmacology, Toxicology, and Therapeutic Innovation, Children's Mercy Hospitals and Clinics, Kansas City, MO, USA.
authors.forename: J Steven
authors.initials: JS
authors.lastname: Leeder
authors.affiliation: Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Departments of Pharmacology & Toxicology and Psychiatry, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Rachel F
authors.initials: RF
authors.lastname: Tyndale
authors.affiliation: Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA.|Department of Pharmacology, University of Missouri-Kansas City School of Pharmacy, Kansas City, MO, USA.|Divisions of Clinical Pharmacology, Toxicology, and Therapeutic Innovation, Children's Mercy Hospitals and Clinics, Kansas City, MO, USA.
authors.forename: Robin E
authors.initials: RE
authors.lastname: Pearce
authors.affiliation: Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA.|Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA.
authors.forename: Daniel K
authors.initials: DK
authors.lastname: Benjamin
authors.affiliation: Arkansas Children's Hospital Research Institute and the Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
authors.forename: Gregory L
authors.initials: GL
authors.lastname: Kearns
authors.affiliation: Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA.|Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Cohen-Wolkowiez
mesh_terms: D000890:Anti-Infective Agents / Q000378:metabolism* / Q000493:pharmacokinetics*; D015331:Cohort Studies; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics* / Q000378:metabolism; D005260:Female; D014644:Genetic Variation; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008795:Metronidazole / Q000378:metabolism* / Q000493:pharmacokinetics*
chemical_list: D000890:Anti-Infective Agents; D008795:Metronidazole; D003577:Cytochrome P-450 Enzyme System
keywords: metabolism; metronidazole; neonates; pharmacokinetics