title: African Americans with pancreatic ductal adenocarcinoma exhibit gender differences in Kaiso expression.
abstract: Kaiso, a bi-modal transcription factor, regulates gene expression, and is elevated in breast, prostate, and colon cancers. Depletion of Kaiso in other cancer types leads to a reduction in markers for the epithelial-mesenchymal transition (EMT) (Jones et al., 2014), however its clinical implications in pancreatic ductal adenocarcinoma (PDCA) have not been widely explored. PDCA is rarely detected at an early stage but is characterized by rapid progression and invasiveness. We now report the significance of the subcellular localization of Kaiso in PDCAs from African Americans. Kaiso expression is higher in the cytoplasm of invasive and metastatic pancreatic cancers. In males, cytoplasmic expression of Kaiso correlates with cancer grade and lymph node positivity. In male and female patients, cytoplasmic Kaiso expression correlates with invasiveness. Also, nuclear expression of Kaiso increases with increased invasiveness and lymph node positivity. Further, analysis of the largest PDCA dataset available on ONCOMINE shows that as Kaiso increases, there is an overall increase in Zeb1, which is the inverse for E-cadherin. Hence, these findings suggest a role for Kaiso in the progression of PDCAs, involving the EMT markers, E-cadherin and Zeb1.
authors.affiliation: Department of Biological and Environmental Sciences, Troy University, Troy, AL 36082, USA.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Jones
authors.affiliation: Department of Biological and Environmental Sciences, Troy University, Troy, AL 36082, USA.
authors.forename: Angana
authors.initials: A
authors.lastname: Mukherjee
authors.affiliation: Department of Biology and Center for Cancer Research, Tuskegee University, Tuskegee, AL 36088, USA.
authors.forename: Balasubramanyam
authors.initials: B
authors.lastname: Karanam
authors.affiliation: Department of Genetics, University of Georgia, Athens, GA 30602, USA.
authors.forename: Melissa
authors.initials: M
authors.lastname: Davis
authors.affiliation: Department of Biology and Center for Cancer Research, Tuskegee University, Tuskegee, AL 36088, USA.
authors.forename: Jesse
authors.initials: J
authors.lastname: Jaynes
authors.affiliation: College of Pharmacy & Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL 32307, USA.
authors.forename: R Renee
authors.initials: RR
authors.lastname: Reams
authors.affiliation: University of Louisiana at Lafayette, Lafayette, Louisiana.
authors.forename: Windy
authors.initials: W
authors.lastname: Dean-Colomb
authors.affiliation: Department of Biology and Center for Cancer Research, Tuskegee University, Tuskegee, AL 36088, USA. Electronic address: cyates@mytu.tuskegee.edu.
authors.forename: Clayton
authors.initials: C
authors.lastname: Yates
mesh_terms: D001741:Black or African American / Q000235:genetics; D015703:Antigens, CD; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000235:genetics; D015820:Cadherins / Q000032:analysis / Q000235:genetics; D021441:Carcinoma, Pancreatic Ductal / Q000737:chemistry* / Q000208:ethnology* / Q000235:genetics / Q000556:secondary; D030541:Databases, Genetic; D058750:Epithelial-Mesenchymal Transition; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000737:chemistry* / Q000208:ethnology* / Q000235:genetics / Q000473:pathology; D012737:Sex Factors; D014157:Transcription Factors / Q000032:analysis* / Q000235:genetics; D047368:Tumor Burden; D014481:United States / Q000453:epidemiology; D000071799:Zinc Finger E-box-Binding Homeobox 1 / Q000032:analysis / Q000235:genetics
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; C513384:CDH1 protein, human; D015820:Cadherins; D014157:Transcription Factors; C492254:ZBTB33 protein, human; C486307:ZEB1 protein, human; D000071799:Zinc Finger E-box-Binding Homeobox 1
keywords: EMT markers; Kaiso; Pancreatic ductal carcinoma