title: Regulating CAR T Cells: A Remote Control Approach.
abstract: Researchers have synthesized small organic molecules called adaptors that have a tumor-specific ligand on one end and FITC on the other. Instead of engineering a different chimeric antigen receptor (CAR) on T cells for each unique tumor antigen, these antigen-specific adaptors can be used to bridge FITC-binding CAR T and tumor cells.
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D016650:Fluorescein-5-isothiocyanate / Q000378:metabolism; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*; D011948:Receptors, Antigen, T-Cell / Q000737:chemistry / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology / Q000637:transplantation*
chemical_list: D011948:Receptors, Antigen, T-Cell; D016650:Fluorescein-5-isothiocyanate