title: Language features in the acute phase of poststroke severe aphasia could predict the outcome.
abstract: BACKGROUND
  Aphasia recovery remains difficult to predict initially in particular for the most severe cases. The features of impaired verbal communication which are the basis for cognitive-linguistic diagnosis and treatment could be part of prediction of recovery from aphasia.
  
  
  OBJECTIVE
  This study investigated whether some components of language screening in the acute phase of stroke are reliable prognostic factors for language recovery in the post-acute phase.
  
  
  METHODS
  Monocentric prospective study.
  
  
  METHODS
  University hospital stroke unit.
  
  
  METHODS
  Eighty-six patients aged between 21 and 92 years (mean=67.4, SD=15.3) were admitted after a first left hemisphere stroke with aphasia and were consecutively included.
  
  
  METHODS
  Language assessment was performed in the acute phase and 3 months post-stroke with the LAnguage Screening Test (LAST) and the Aphasia Severity Rating Scale (ASRS) of the Boston Diagnostic Aphasia Examination (BDAE). Severe aphasia was defined as ASRS<3. Good recovery was defined as an ASRS≥4. Language scores and other potential predictors of recovery were analysed by comparing groups of patients with good versus poor recovery and as predictors of change with multiple regression approaches.
  
  
  RESULTS
  LAST Total score as well as all the individual items of LAST, NIHSS and ASRS measured in the acute phase significantly differentiated good and poor recovery from aphasia at three months for all aphasic patients and for the most severe cases. In multivariable analyses the repetition score of LAST at the acute phase was significantly associated with the delta of ASRS between the acute phase and 3 months after the stroke reflecting changes in symptom severity.
  
  
  CONCLUSIONS
  For patients with initial severe aphasia, word repetition from a language screening task seems to be a more relevant predictor of recovery than initial severity to enrich the prognosis of poststroke aphasia recovery three month after a stroke. These findings show the importance of phonological perception and production as well as speech motor components in the recovery of language. These linguistic aspects of the assessment seem more relevant than severity for prediction in the acute phase.
  
  
  CONCLUSIONS
  These findings could improve aphasia management pathway for people with severe aphasia and their families and minimize the evidence-practice gap for speech pathologists.
authors.affiliation: Physical and Rehabilitation Medicine Unit, EA4136, Bordeaux University Hospital, University of Bordeaux, Bordeaux, France - bertrand.glize@chu-bordeaux.fr.
authors.forename: Bertrand
authors.initials: B
authors.lastname: Glize
authors.affiliation: Neurology, Stroke Unit, INCIA CNRS UMR 5287, Bordeaux University Hospital, University of Bordeaux, Bordeaux, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Villain
authors.affiliation: Pôle de Sante Publique, Bordeaux University Hospital, University of Bordeaux, Bordeaux, France.
authors.forename: Laura
authors.initials: L
authors.lastname: Richert
authors.affiliation: Physical and Rehabilitation Medicine Unit, EA4136, Bordeaux University Hospital, University of Bordeaux, Bordeaux, France.
authors.forename: Maeva
authors.initials: M
authors.lastname: Vellay
authors.affiliation: Neurology, Stroke Unit, INCIA CNRS UMR 5287, Bordeaux University Hospital, University of Bordeaux, Bordeaux, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: de Gabory
authors.affiliation: Physical and Rehabilitation Medicine Unit, EA4136, Bordeaux University Hospital, University of Bordeaux, Bordeaux, France.
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Mazaux
authors.affiliation: Physical and Rehabilitation Medicine Unit, EA4136, Bordeaux University Hospital, University of Bordeaux, Bordeaux, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Dehail
authors.affiliation: Neurology, Stroke Unit, INCIA CNRS UMR 5287, Bordeaux University Hospital, University of Bordeaux, Bordeaux, France.
authors.forename: Igor
authors.initials: I
authors.lastname: Sibon
authors.affiliation: Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland.
authors.forename: Marina
authors.initials: M
authors.lastname: Laganaro
authors.affiliation: Physical and Rehabilitation Medicine Unit, EA4136, Bordeaux University Hospital, University of Bordeaux, Bordeaux, France.
authors.forename: Pierre-Alain
authors.initials: PA
authors.lastname: Joseph
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001037:Aphasia / Q000209:etiology / Q000503:physiopathology* / Q000534:rehabilitation; D005260:Female; D006801:Humans; D007802:Language; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D020127:Recovery of Function; D013060:Speech / Q000502:physiology*; D020521:Stroke / Q000150:complications*; D055815:Young Adult