title: Data describing the solution structure of the WW3* domain from human Nedd4-1.
abstract: The third WW domain (WW3*) of human Nedd4-1 (Neuronal precursor cell expressed developmentally down-regulated gene 4-1) interacts with the poly-proline (PY) motifs of the human epithelial Na+ channel (hENaC) subunits at micromolar affinity. This data supplements the article (Panwalkar et al., 2015) [1]. We describe the NMR experiments used to solve the solution structure of the WW3* domain. We also present NOE network data for defining the rotameric state of side chains of peptide binding residues, and complement this data with χ 1 dihedral angles derived from (3) J couplings and molecular dynamics simulations data.
authors.affiliation: ICS-6 Strukturbiochemie, Forschungszentrum Jülich, 52425 Jülich, Germany.
authors.forename: Vineet
authors.initials: V
authors.lastname: Panwalkar
authors.affiliation: ICS-6 Strukturbiochemie, Forschungszentrum Jülich, 52425 Jülich, Germany; Institut für Physikalische Biologie, Heinrich-Heine-Universität, 40225 Düsseldorf, Germany.
authors.forename: Marianne
authors.initials: M
authors.lastname: Schulte
authors.affiliation: ICS-6 Strukturbiochemie, Forschungszentrum Jülich, 52425 Jülich, Germany; Institut für Physikalische Biologie, Heinrich-Heine-Universität, 40225 Düsseldorf, Germany.
authors.forename: Justin
authors.initials: J
authors.lastname: Lecher
authors.affiliation: ICS-6 Strukturbiochemie, Forschungszentrum Jülich, 52425 Jülich, Germany; Institut für Physikalische Biologie, Heinrich-Heine-Universität, 40225 Düsseldorf, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Stoldt
authors.affiliation: ICS-6 Strukturbiochemie, Forschungszentrum Jülich, 52425 Jülich, Germany; Institut für Physikalische Biologie, Heinrich-Heine-Universität, 40225 Düsseldorf, Germany.
authors.forename: Dieter
authors.initials: D
authors.lastname: Willbold
authors.affiliation: ICS-6 Strukturbiochemie, Forschungszentrum Jülich, 52425 Jülich, Germany.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Dingley
keywords: Chemical shift; NMR; NOE distance restraints; Neuronal precursor cell expressed developmentally down-regulated gene 4-1; WW domain