title: -759C>T Polymorphism of the HTR2C Gene is Associated with Second Generation Antipsychotic-Induced Weight Gain in Female Patients with Schizophrenia.
abstract: Introduction:TheHTR2Cgene is an important candidate in pharmacogenetic studies of antipsychotic-induced weight gain (AIWG). However, inconsistent results have been obtained. The present study investigated the association between -759C>T, functional polymorphism of theHTR2Creceptor, and AIWG.Methods:A prospective cohort of 48 female inpatients with schizophrenia and related illness treated according to normal clinical practice with second generation antipsychotics (SGAs) risperidone, clozapine, quetiapine, and olanzapine were evaluated. Patients were weighted at admission and again at 6 weeks of hospitalization. Weight gain was defined as an increase≥7% of baseline weight. The association between polymorphismsHTR2Cand weight gain was evaluated. Multiple logistic regression was run to determine potential confounders.Results:Patients with the T allele at position -759 (TT or CT) gained less weight as compared to patients who did not have the allele. This association was not affected by possible confounding factors such as age, baseline BMI, and prior psychopharmacological treatment.Discussion:The T allele at position -759 protects against AIWG in female patients with schizophrenia.
authors.affiliation: Instituto de Farmacología, Facultad de Medicina, Universidad de Buenos Aires. Argentina. Paraguay 2155, piso 9, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Federico Manuel
authors.initials: FM
authors.lastname: Daray
authors.affiliation: Instituto de Farmacología, Facultad de Medicina, Universidad de Buenos Aires. Argentina. Paraguay 2155, piso 9, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Demián
authors.initials: D
authors.lastname: Rodante
authors.affiliation: Servicio de Emergencia, Hospital "Braulio A. Moyano", Buenos Aires, Argentina.
authors.forename: Laura G
authors.initials: LG
authors.lastname: Carosella
authors.affiliation: Servicio de Emergencia, Hospital "Braulio A. Moyano", Buenos Aires, Argentina.
authors.forename: María Elena
authors.initials: ME
authors.lastname: Silva
authors.affiliation: Laboratorio de Microbiología Molecular, Universidad Nacional de Quilmes, Argentina.
authors.forename: Melina
authors.initials: M
authors.lastname: Martínez
authors.affiliation: Laboratorio de Microbiología Molecular, Universidad Nacional de Quilmes, Argentina.
authors.forename: María V
authors.initials: MV
authors.lastname: Fernández Busch
authors.affiliation: Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.
authors.forename: Diego F
authors.initials: DF
authors.lastname: Faccone
authors.affiliation: Instituto de Farmacología, Facultad de Medicina, Universidad de Buenos Aires. Argentina. Paraguay 2155, piso 9, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Rodolfo P
authors.initials: RP
authors.lastname: Rothlin
authors.affiliation: Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.
authors.forename: Paulo C
authors.initials: PC
authors.lastname: Maffía
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D005260:Female; D005820:Genetic Testing; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D044405:Receptor, Serotonin, 5-HT2C / Q000235:genetics*; D012559:Schizophrenia / Q000188:drug therapy; D015430:Weight Gain / Q000187:drug effects* / Q000235:genetics*; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D044405:Receptor, Serotonin, 5-HT2C