title: Identification of lung-specific genes by meta-analysis of multiple tissue RNA-seq data.
abstract: Lung-specific genes play critically important roles in lung development, lung physiology, and pathogenesis of lung-associated diseases. We performed a meta-analysis of multiple tissue RNA-seq data to identify lung-specific genes in order to better investigate their lung-specific functions and pathological roles. We identified 83 lung-specific genes consisting of 62 protein-coding genes, five pseudogenes and 16 noncoding RNA genes. About 49.4% of lung-specific genes were implicated in the pathogenesis of lung diseases and 21.7% were involved with lung development. The identification of genes with enriched expression in the lung will facilitate the elucidation of lung-specific functions and their roles in disease pathogenesis.
authors.affiliation: Division of Experimental and Translational Genetics Department of Pediatrics The Children's Mercy Hospital University of Missouri Kansas City School of Medicine MO USA; Department of Biomedical and Health Informatics University of Missouri Kansas City School of Medicine MO USA.
authors.forename: Min
authors.initials: M
authors.lastname: Xiong
authors.affiliation: Division of Experimental and Translational Genetics Department of Pediatrics The Children's Mercy Hospital University of Missouri Kansas City School of Medicine MO USA.
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Heruth
authors.affiliation: Division of Experimental and Translational Genetics Department of Pediatrics The Children's Mercy Hospital University of Missouri Kansas City School of Medicine MO USA.
authors.forename: Li Qin
authors.initials: LQ
authors.lastname: Zhang
authors.affiliation: Division of Experimental and Translational Genetics Department of Pediatrics The Children's Mercy Hospital University of Missouri Kansas City School of Medicine MO USA; Department of Biomedical and Health Informatics University of Missouri Kansas City School of Medicine MO USA.
authors.forename: Shui Qing
authors.initials: SQ
authors.lastname: Ye
keywords: RNA‐seq; genome; lung development genes; lung‐associated disease; lung‐specific genes