title: Correlation between the transdermal characteristics of pseudoephedrine and amygdalin in majiepingchuan in vitro.
abstract: OBJECTIVE
  To analyze the transdermal profile of pseudoephedrine and amygdalin in the Traditional Chinese Medicine majiepingchuan in rat skin and to reveal their interaction.
  
  
  METHODS
  A Franz diffusion cell was used in vitro to evaluate the transdermal parameters of cumulative transdermal flux (Q(tot)), cumulative transmission (T(tot)), and mean penetration rate (Kp) of pseudoephedrine and amygdalin in majiepingchuan. Linear regression analyses of Q(tot) over time of pseudoephedrine vs amygdalin and their ratios was adopted for correlation evaluation.
  
  
  RESULTS
  At 1, 2, 4, 6, and 8 h, the Q(tot), T(tot) and Kp of pseudoephedrine showed a good correlation with that of amygdalin.
  
  
  CONCLUSIONS
  There was a small difference in the ratios of Q(tot), T(tot) and Kp between pseudoephedrine and amygdalin, and a correlation between them.
authors.forename: Hui
authors.initials: H
authors.lastname: Kong
authors.forename: Huihua
authors.initials: H
authors.lastname: Qu
authors.forename: Baoping
authors.initials: B
authors.lastname: Qu
authors.forename: Wenhao
authors.initials: W
authors.lastname: Zeng
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao
authors.forename: Xueqian
authors.initials: X
authors.lastname: Wang
authors.forename: Qingguo
authors.initials: Q
authors.lastname: Wang
mesh_terms: D000279:Administration, Cutaneous; D000678:Amygdalin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D054199:Pseudoephedrine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000737:chemistry / Q000378:metabolism
chemical_list: D004365:Drugs, Chinese Herbal; D000678:Amygdalin; D054199:Pseudoephedrine