title: Reconstituting the Human Immune System.
abstract: Studying checkpoint blockers and other new immunotherapies is challenging in traditional mouse models because the animals lack B and T cells and have impaired innate immunity. To address these shortcomings, researchers are making progress in reconstituting the human immune system in immunodeficient mouse models.
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D007107:Immune System / Q000276:immunology* / Q000378:metabolism; D007167:Immunotherapy; D008822:Mice, Transgenic; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy*