title: Genitourinary tumours in the targeted therapies era: new advances in clinical practice and future perspectives.
abstract: Genitourinary cancers represent a heterogeneous group of malignancies arising from genitourinary tract, and are responsible for almost 359 000 newly diagnosed cases and 58 420 related deaths in USA. Continuous advances in cancer genetics and genomics have contributed towards changing the management paradigms of these neoplasms. Neoangiogenesis, through the activation of the tyrosine-kinase receptors signalling pathways, represents the key mediator event in promoting tumour proliferation, differentiation, invasiveness and motility. In the last decade, several treatments have been developed with the specific aim of targeting different cell pathways that have been recognized to drive tumour progression. The following review attempts to provide a comprehensive overview of the literature, focusing on new advances in targeted therapies for genitourinary tumours. Furthermore, the promising results of the latest clinical trials and future perspectives will be discussed.
authors.affiliation: aAcademic Unit of Medical Oncology, IRCCS San Martino University Hospital - IST National Cancer Research Institute bDepartment of Internal Medicine, School of Medicine, University of Genoa, Genoa, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Messina
authors.forename: Giulia
authors.initials: G
authors.lastname: Buzzatti
authors.forename: Chiara
authors.initials: C
authors.lastname: Dellepiane
authors.forename: Alessia
authors.initials: A
authors.lastname: Cavo
authors.forename: Francesco
authors.initials: F
authors.lastname: Tolomeo
authors.forename: Carlo
authors.initials: C
authors.lastname: Cattrini
authors.forename: Francesco
authors.initials: F
authors.lastname: Boccardo
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D058990:Molecular Targeted Therapy; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors; D016032:Randomized Controlled Trials as Topic; D014565:Urogenital Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D011505:Protein-Tyrosine Kinases