title: Pink Light on Mitochondria in Autoimmunity and Parkinson Disease.
abstract: Mitochondrial dysfunction and T cell autoimmunity have been independently implicated in Parkinson disease pathogenesis. In a recent publication in Cell, Matheoud et al. (2016) link them by describing a new mechanism, activated in familial forms of Parkinson disease, in which mitochondrial proteins are processed for recognition by CD8+ T cells.
authors.affiliation: Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Adriana R
authors.initials: AR
authors.lastname: Mantegazza
authors.affiliation: Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: marksm@mail.med.upenn.edu.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Marks
mesh_terms: D015551:Autoimmunity; D006801:Humans; D008928:Mitochondria; D024101:Mitochondrial Proteins; D010300:Parkinson Disease
chemical_list: D024101:Mitochondrial Proteins