title: The Multifaceted Role of Perivascular Macrophages in Tumors.
abstract: Evidence has emerged for macrophages in the perivascular niche of tumors regulating important processes like angiogenesis, various steps in the metastatic cascade, the recruitment and activity of other tumor-promoting leukocytes, and tumor responses to frontline therapies like irradiation and chemotherapy. Understanding the mechanisms controlling the recruitment, retention, and function of these cells could identify important targets for anti-cancer therapeutics.
authors.affiliation: Department of Oncology and Metabolism, University of Sheffield Medical School, Sheffield S10 2RX, UK. Electronic address: claire.lewis@sheffield.ac.uk.
authors.forename: Claire E
authors.initials: CE
authors.lastname: Lewis
authors.affiliation: Departments of Anatomy and Structural Biology, Developmental and Molecular Biology, Albert Einstein College of Medicine, New York 10461, USA.
authors.forename: Allison S
authors.initials: AS
authors.lastname: Harney
authors.affiliation: Departments of Anatomy and Structural Biology, Developmental and Molecular Biology, Albert Einstein College of Medicine, New York 10461, USA; MRC Centre for Reproductive Health, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK. Electronic address: jeff.pollard@ed.ac.uk.
authors.forename: Jeffrey W
authors.initials: JW
authors.lastname: Pollard
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D018450:Disease Progression; D006801:Humans; D008264:Macrophages / Q000378:metabolism* / Q000473:pathology*; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000098:blood supply / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D009389:Neovascularization, Pathologic; D016896:Treatment Outcome; D059016:Tumor Microenvironment
chemical_list: D014408:Biomarkers, Tumor