title: Crowdsourcing biomedical research: leveraging communities as innovation engines.
abstract: The generation of large-scale biomedical data is creating unprecedented opportunities for basic and translational science. Typically, the data producers perform initial analyses, but it is very likely that the most informative methods may reside with other groups. Crowdsourcing the analysis of complex and massive data has emerged as a framework to find robust methodologies. When the crowdsourcing is done in the form of collaborative scientific competitions, known as Challenges, the validation of the methods is inherently addressed. Challenges also encourage open innovation, create collaborative communities to solve diverse and important biomedical problems, and foster the creation and dissemination of well-curated data repositories.
authors.affiliation: RWTH Aachen University, Faculty of Medicine, Joint Research Centre for Computational Biomedicine, Aachen D-52074, Germany.|European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton CB10 1SD, UK.
authors.forename: Julio
authors.initials: J
authors.lastname: Saez-Rodriguez
authors.affiliation: Department of Pharmacology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045, USA.
authors.forename: James C
authors.initials: JC
authors.lastname: Costello
authors.affiliation: Sage Bionetworks, Seattle, Washington 98109, USA.
authors.forename: Stephen H
authors.initials: SH
authors.lastname: Friend
authors.affiliation: Sage Bionetworks, Seattle, Washington 98109, USA.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Kellen
authors.affiliation: Sage Bionetworks, Seattle, Washington 98109, USA.
authors.forename: Lara
authors.initials: L
authors.lastname: Mangravite
authors.affiliation: IBM Thomas J. Watson Research Center, Yorktown Heights, New York 10598, USA.
authors.forename: Pablo
authors.initials: P
authors.lastname: Meyer
authors.affiliation: Sage Bionetworks, Seattle, Washington 98109, USA.
authors.forename: Thea
authors.initials: T
authors.lastname: Norman
authors.affiliation: IBM Thomas J. Watson Research Center, Yorktown Heights, New York 10598, USA.|Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Stolovitzky
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000458:organization & administration*; D003299:Cooperative Behavior; D063045:Crowdsourcing; D006801:Humans; D033183:Interdisciplinary Communication; D009936:Organizational Innovation; D057170:Translational Research, Biomedical / Q000458:organization & administration*