title: Metastatic neuroendocrine tumor of small cell type in a kidney transplant recipient.
abstract: Malignancy is a significant long-term complication of successful renal transplantation. Not only the rate is higher but also cases are highly aggressive. We report a case of metastatic, small cell, neuroendocrine tumor in a post-renal transplant patient with progressive left inguinal nodes and right lumbar swellings. He had a remarkably elevated serum lactate dehydrogenase levels with multiple metastatic masses in the left inguinal, left iliac fossa, and right lower abdominal wall on abdominal computed tomography scan. Excisional biopsy of a left inguinal node revealed extensive infiltration with malignant cells in it. Immunohistochemistry staining was positive for synaptophysin, prostatic specific antigen, and CD56. While the primary small cell carcinoma of genitourinary organs is rare, the case illustrates the highly aggressive nature of the disease in a kidney transplant recipient.
authors.affiliation: Department of Nephrology, Hospital Tengku Ampuan Afzan, Pahang, Malaysia.
authors.forename: A
authors.initials: A
authors.lastname: Mohd Kamil
authors.affiliation: Department of Internal Medicine, Kulliyyah of Medicine, International Islamic University Malaysia, Pahang, Malaysia.
authors.forename: Che Rosle
authors.initials: CR
authors.lastname: Draman
authors.affiliation: Department of Nephrology, Hospital Tengku Ampuan Afzan, Pahang, Malaysia.
authors.forename: Mohd Ramli
authors.initials: MR
authors.lastname: Seman
authors.affiliation: Department of Pathology, Hospital Tengku Ampuan Afzan, Pahang, Malaysia.
authors.forename: R
authors.initials: R
authors.lastname: Kalavathy
authors.affiliation: Department of Radiology, Hospital Tengku Ampuan Afzan, Pahang, Malaysia.
authors.forename: M Y
authors.initials: MY
authors.lastname: Mubarak
mesh_terms: D006801:Humans; D007668:Kidney; D007680:Kidney Neoplasms; D016030:Kidney Transplantation; D008207:Lymphatic Metastasis; D008297:Male; D018358:Neuroendocrine Tumors