title: Plasma phospholipids and prevalence of mild cognitive impairment and/or dementia in the ARIC Neurocognitive Study (ARIC-NCS).
abstract: BACKGROUND
  Phospholipids are altered in brains of patients with dementia and some studies suggest their plasma levels may be useful in the detection of mild cognitive impairment (MCI) and dementia.
  
  
  METHODS
  We measured 188 plasma metabolites in participants who underwent a detailed neuropsychological assessment and classified as normal (n = 153), MCI (n = 145), or dementia (n = 143) by expert adjudication.
  
  
  RESULTS
  Among 10 phospholipids recently implicated as altered in dementia, higher concentration of PC aa C36:6 was significantly associated with decreased prevalence of dementia (odds ratio = 0.71, 95% confidence interval = 0.50-1.00 per 1-SD increase). Adding these phospholipids to a model including multiple predictors of dementia led to only minimal improvement in detection (C statistic changed from 0.702 to 0.71).
  
  
  CONCLUSIONS
  Some phospholipids and metabolites were altered in MCI and dementia but cross-sectional association was relatively weak and did not improve detection of MCI and dementia beyond information provided by clinical variables.
authors.affiliation: Department of Lab Medicine and Pathology, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Danni
authors.initials: D
authors.lastname: Li
authors.affiliation: Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Misialek
authors.affiliation: School of Public Health, University of Texas Health Science Center, Houston, TX, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Boerwinkle
authors.affiliation: Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Rebecca F
authors.initials: RF
authors.lastname: Gottesman
authors.affiliation: School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: A Richey
authors.initials: AR
authors.lastname: Sharrett
authors.affiliation: Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Mosley
authors.affiliation: School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Josef
authors.initials: J
authors.lastname: Coresh
authors.affiliation: Collaborative Studies Coordinating Center, University of North Carolina, Chapel Hill, NC, USA.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Wruck
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, MN, USA.
authors.forename: David S
authors.initials: DS
authors.lastname: Knopman
authors.affiliation: Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Alvaro
authors.initials: A
authors.lastname: Alonso
keywords: AD; ARIC; ARIC-NCS; Alzheimer's disease; Dementia; MCI; Metabolites; Metabolomics; Mild cognitive impairment; Phospholipids; Plasma