title: [Identification of 3-demethylchuangxinmycin from Actinoplanes tsinanensis CPCC 200056].
abstract: Chuangxinmycin (CM) from Actinoplanes tsinanensis was an antibiotic discovered by Chinese scientists about 40 years ago. It contains a new heterocyclic system of indole fused with dihydrothiopyran, whose biosynthetic mechanism remains unclear. CM is used as an oral medicine in the treatment of bacterial infections in China. The simple structure makes CM as an attractive candidate of structure modification for improvement of antibacterial activity. Recently, we analyzed the secondary metabolites of Actinoplanes tsinanensis CPCC 200056, a CM producing strain, as a natural CM analogue. We discovered the first natural CM analogue 3-demethylchuangxinmycin (DCM) as a new natural product. Compared to CM, DCM exhibited a much weaker activity in the inhibition of the bacterial strains tested. The finding provides valuable information for the structure-activity relationship in the biosynthesis of CM.
authors.forename: Li-jie
authors.initials: LJ
authors.lastname: Zuo
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
authors.forename: Zhi-bo
authors.initials: ZB
authors.lastname: Jiang
authors.forename: Bing-ya
authors.initials: BY
authors.lastname: Jiang
authors.forename: Shu-fen
authors.initials: SF
authors.lastname: Li
authors.forename: Hong-yu
authors.initials: HY
authors.lastname: Liu
authors.forename: Li-yan
authors.initials: LY
authors.lastname: Yu
authors.forename: Bin
authors.initials: B
authors.lastname: Hong
authors.forename: Xin-xin
authors.initials: XX
authors.lastname: Hu
authors.forename: Xue-fu
authors.initials: XF
authors.lastname: You
authors.forename: Lin-zhuan
authors.initials: LZ
authors.lastname: Wu
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification*; D002681:China; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification; D008848:Micromonosporaceae / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D007211:Indoles; C014414:chuangxinmycin