title: Novel myosin-based therapies for congenital cardiac and skeletal myopathies.
abstract: The dysfunction in a number of inherited cardiac and skeletal myopathies is primarily due to an altered ability of myofilaments to generate force and motion. Despite this crucial knowledge, there are, currently, no effective therapeutic interventions for these diseases. In this short review, we discuss recent findings giving strong evidence that genetically or pharmacologically modulating one of the myofilament proteins, myosin, could alleviate the muscle pathology. This should constitute a research and clinical priority.
authors.affiliation: Centre of Human and Aerospace Physiological Sciences, King's College London, London, UK.
authors.forename: Julien
authors.initials: J
authors.lastname: Ochala
authors.affiliation: Randall Division of Cell and Molecular Biophysics, British Heart Foundation Centre of Research Excellence, King's College London, London, UK.
authors.forename: Yin-Biao
authors.initials: YB
authors.lastname: Sun
mesh_terms: D000818:Animals; D009202:Cardiomyopathies / Q000151:congenital / Q000378:metabolism / Q000628:therapy*; D006801:Humans; D009135:Muscular Diseases / Q000151:congenital / Q000378:metabolism / Q000628:therapy*; D009218:Myosins
chemical_list: D009218:Myosins
keywords: Cardiomyopathy; Congenital heart disease; Muscle disease