title: Plasma kinetics of essential amino acids following their ingestion as free formula or as dietary protein components.
abstract: This investigation compares the levels of plasma kinetics of plasma essential amino acids (EAAs) after ingestion as free-form EAAs (FEAAs) or EAAs as components of dietary protein (DPEAAs), in eighteen healthy individuals, nine elderly (85 ± 6.7 years; 4 male) and nine young (28.7 ± 7 years; 3 males). For two consecutive days, each subject ingested EAAs in the form of (FEAAs) or (DPEAAs) in a random alternate pattern. Five minutes before EAA ingestion (baseline) and 30, 60, 90, 150 and 270 min after, venous blood samples were taken to determine the concentrations of EAAS (micromol/L). In both groups, ingested FEAAs compared to DPEAAs led to faster increase in plasma EAA levels at 30-150 min (p < 0.0001). Moreover, the increased plasma EAAs disappeared faster after FEAA compared to DPEAA. These results may be important in those subjects who have high requirement both for EAAs substrates and anabolic efficiency.
authors.affiliation: Department of Public Health, Experimental Medicine & Forensic Section of Human Nutrition and Dietetics, School of Medicine, Azienda di Servizi alla Persona di Pavia, Servizio Endocrino Nutrizionale, Istituto di Riabilitazione "Santa Margherita", University of Pavia, 27100, Pavia, Italy.
authors.forename: Mariangela
authors.initials: M
authors.lastname: Rondanelli
authors.affiliation: Dipartimento di Biologia e Biotecnologie, Università degli Studi di Pavia, Via Ferrata, 9, 27100, Pavia, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Aquilani
authors.affiliation: Dipartimento di Biologia e Biotecnologie, Università degli Studi di Pavia, Via Ferrata, 9, 27100, Pavia, Italy.
authors.forename: Manuela
authors.initials: M
authors.lastname: Verri
authors.affiliation: Department of Drug Sciences, Università degli Studi di Pavia, Viale Taramelli, 14, 27100, Pavia, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Boschi
authors.affiliation: Fondazione S. Maugeri, IRCCS, Istituto Scientifico di Lumezzane, Via Mazzini, 9, 25065, Lumezzane, Brescia, Italy.
authors.forename: Evasio
authors.initials: E
authors.lastname: Pasini
authors.affiliation: Department of Public Health, Experimental Medicine & Forensic Section of Human Nutrition and Dietetics, School of Medicine, Azienda di Servizi alla Persona di Pavia, Servizio Endocrino Nutrizionale, Istituto di Riabilitazione "Santa Margherita", University of Pavia, 27100, Pavia, Italy.
authors.forename: Simone
authors.initials: S
authors.lastname: Perna
authors.affiliation: Department of Public Health, Experimental Medicine & Forensic Section of Human Nutrition and Dietetics, School of Medicine, Azienda di Servizi alla Persona di Pavia, Servizio Endocrino Nutrizionale, Istituto di Riabilitazione "Santa Margherita", University of Pavia, 27100, Pavia, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Faliva
authors.affiliation: Department of Drug Sciences, Università degli Studi di Pavia, Viale Taramelli, 14, 27100, Pavia, Italy. annamaria.condino@unipv.it.
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Condino
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000601:Amino Acids, Essential / Q000097:blood* / Q000493:pharmacokinetics; D004044:Dietary Proteins / Q000097:blood* / Q000493:pharmacokinetics; D004435:Eating; D005260:Female; D006801:Humans; D008297:Male; D009124:Muscle Proteins / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism*; D055815:Young Adult
chemical_list: D000601:Amino Acids, Essential; D004044:Dietary Proteins; D009124:Muscle Proteins
keywords: Elderly; Essential amino acids; Skeletal muscle