title: [EFFECT OF MEDIATOR-TYPE DRUGS ON HUMAN PSYCHOPHYSIOLOGICAL STATUS DURING MODEL OPERATOR ACTIVITY].
abstract: In a placebo-controlled study, changes in psychophysiological status of operators (38 healthy male volunteers aged 23-35 years) performing 4-hour model operator activity were evaluated after a single oral administration of typical representatives of the different classes of drugs (haloperidol, proroxan, yohimbine hydrochloride, propranolol, mesocarb, isoprenaline, Belladonna extract, anabasine hydrochloride, valproate sodium, and phenazepam), which are used for the treatment, rehabilitation and prophylaxis of common diseases. It was found that all the drugs modified to a greater or lesser extent some components of the model operator activity. Isoprenaline and phenazepam had the most negative effect on the psychophysiological indicators and quality of the modeled operator activity. The results should be considered before administration of such drugs to working operators.
authors.forename: U K
authors.initials: UK
authors.lastname: Kundashev
authors.forename: Yu A
authors.initials: YA
authors.lastname: Salenko
authors.forename: I S
authors.initials: IS
authors.lastname: Morozov
authors.forename: A Z
authors.initials: AZ
authors.lastname: Zurdinov
authors.forename: V G
authors.initials: VG
authors.lastname: Barchukov
mesh_terms: D000328:Adult; D000691:Anabasine / Q000494:pharmacology; D001288:Attention / Q000187:drug effects* / Q000502:physiology; D001533:Belladonna Alkaloids / Q000494:pharmacology; D001569:Benzodiazepines / Q000494:pharmacology; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D004146:Dioxanes / Q000494:pharmacology; D004311:Double-Blind Method; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D011433:Propranolol / Q000494:pharmacology; D011603:Psychophysiology; D013558:Sydnones / Q000494:pharmacology; D013647:Task Performance and Analysis; D014149:Tranquilizing Agents / Q000494:pharmacology*; D014635:Valproic Acid / Q000494:pharmacology; D015016:Yohimbine / Q000494:pharmacology
chemical_list: D001533:Belladonna Alkaloids; D000697:Central Nervous System Stimulants; D004146:Dioxanes; D013558:Sydnones; D014149:Tranquilizing Agents; D001569:Benzodiazepines; D015016:Yohimbine; C017928:phenazepam; D014635:Valproic Acid; D011433:Propranolol; D006220:Haloperidol; D007545:Isoproterenol; D000691:Anabasine; C009143:proroxan; C009257:sidnocarb