title: A new flavonol from the kino of Eucalyptus citriodora.
abstract: A new flavonol, 6-[1-(p-hydroxyphenyl)ethyl]rhamnocitrin (3) together with two known compounds, kaempferol (4) and 7-O-methyl aromadendrin (5) were isolated from the kino of Eucalyptus citriodora and their structures were elucidated on the basis of spectroscopic methods including 2D NMR spectra. Rhamnocitrin (1), 6-[1-(p-hydroxyphenyl)ethyl]-7-O-methyl aromadendrin (2), previously isolated from this plant and compounds 3-5 were tested for inhibitory activity against 15-lipoxygenase. All compounds exhibited moderate to strong inhibitory activities, of which compounds 2, 3 and 5 showed stronger inhibitory activity (IC5019.7 ± 0.5, 29.3 ± 0.9 and 31.4 ± 1.0 μM, respectively) than the positive control quercetin (IC5037.5 ± 0.8 μM).
authors.affiliation: a Department of Medicinal Chemistry , Chia-Nan University of Pharmacy and Science , Tainan , Taiwan, ROC.
authors.forename: Shwu-Woan
authors.initials: SW
authors.lastname: Lee
authors.affiliation: b Department of Cosmetic Science and Institude of Cosmetic Science , Chia Nan University of Pharmacy and Science , Tainan , Taiwan, ROC.
authors.forename: Wei-Jing
authors.initials: WJ
authors.lastname: Hung
authors.affiliation: a Department of Medicinal Chemistry , Chia-Nan University of Pharmacy and Science , Tainan , Taiwan, ROC.
authors.forename: Zong-Tsi
authors.initials: ZT
authors.lastname: Chen
mesh_terms: D000975:Antioxidants / Q000494:pharmacology; D001093:Arachidonate 15-Lipoxygenase; D005052:Eucalyptus / Q000737:chemistry*; D044948:Flavonols / Q000737:chemistry* / Q000494:pharmacology*; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D011794:Quercetin / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: C000618175:6-(1-(p-hydroxyphenyl)ethyl)rhamnocitrin; D000975:Antioxidants; D044948:Flavonols; D016859:Lipoxygenase Inhibitors; D011794:Quercetin; D001093:Arachidonate 15-Lipoxygenase
keywords: Eucalyptus citriodora; flavonoids; kino; lipoxygenase