title: Deep brain stimulation and climbing fiber synaptic pathology in essential tremor.
abstract: Essential tremor (ET) patients have abnormal climbing fiber (CF) synapses in the parallel fiber territory in the cerebellum, and these abnormal CF synapses are inversely correlated with tremor severity. We therefore examined CF synaptic pathology in ET cases with and without thalamic deep brain stimulation (DBS) and assessed the association with tremor severity. We found that CF synaptic pathology was inversely correlated with tremor severity in ET cases without DBS, and this correlation disappeared in ET cases with DBS. Our data suggest that DBS might have effects in modulating excitatory synapses in ET cerebellum, in addition to its symptomatic effects on tremor. Ann Neurol 2016;80:461-465.
authors.affiliation: Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY. sk3295@columbia.edu.
authors.forename: Sheng-Han
authors.initials: SH
authors.lastname: Kuo
authors.affiliation: Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY.|Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY.
authors.forename: Chi-Ying
authors.initials: CY
authors.lastname: Lin
authors.affiliation: Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY.|Department of Basic and Community Nursing, School of Nursing, Nanjing Medical University, Nanjing, Jiangsu Province, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY.
authors.forename: Jyun-You
authors.initials: JY
authors.lastname: Liou
authors.affiliation: Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY.|Department of Medical Research, National Taiwan University, Taipei, Taiwan.
authors.forename: Ming-Kai
authors.initials: MK
authors.lastname: Pan
authors.affiliation: Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY.
authors.forename: Ravi J
authors.initials: RJ
authors.lastname: Louis
authors.affiliation: Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY.
authors.forename: Wei-Pu
authors.initials: WP
authors.lastname: Wu
authors.affiliation: Department of Neurology, Yale School of Medicine, Yale University, New Haven, CT.
authors.forename: Jesus
authors.initials: J
authors.lastname: Gutierrez
authors.affiliation: Department of Neurology, Yale School of Medicine, Yale University, New Haven, CT.|Department of Chronic Disease Epidemiology, Yale School of Public Health, Yale University, New Haven, CT.|Center for Neuroepidemiology and Clinical Neurological Research, Yale School of Medicine, Yale University, New Haven, CT.
authors.forename: Elan D
authors.initials: ED
authors.lastname: Louis
authors.affiliation: Department of Pathology and Cell Biology, Columbia University Medical Center and the New York Presbyterian Hospital, New York, NY.
authors.forename: Phyllis L
authors.initials: PL
authors.lastname: Faust
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002526:Cerebellar Diseases / Q000473:pathology*; D046690:Deep Brain Stimulation; D020329:Essential Tremor / Q000503:physiopathology* / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D009412:Nerve Fibers / Q000473:pathology*; D012720:Severity of Illness Index; D013569:Synapses / Q000473:pathology*