title: Increased serum renalase in hemodialysis patients: is it related to left ventricular hypertrophy?
abstract: BACKGROUND
  Left ventricular hypertrophy (LVH) is one of the most common cardiac abnormalities in patients with end stage renal disease (ESRD). Hypertension, diabetes, increased body mass index, gender, age, anemia, and hyperparathyroidism have been described as risk factors for LVH in patients on dialysis. However, there may be other risk factors which have not been described yet. Recent studies show that renalase is associated with cardiovascular events. The aim of this study was to reveal the relation between renalase, LVH in patients under hemodialysis (HD) treatment.
  
  
  METHODS
  The study included 50 HD patients and 35 healthy controls. Serum renalase levels and left ventricle mass index (LVMI) were measured in all participants and the relation between these variables was examined.
  
  
  RESULTS
  LVMI was positively correlated with dialysis vintage and C-reactive protein (CRP) (r = 0.387, p = 0.005 and r = 0.597, p < 0.001, respectively) and was negatively correlated with residual diuresis and hemoglobin levels (r = -0.324, p = 0.022 and r = -0.499, p < 0.001, respectively). There was no significant association of renalase with LVMI in the HD patients (r = 0.263, p = 0.065). Serum renalase levels were significantly higher in HD patients (212 ± 127 ng/mL) compared to controls (116 ± 67 ng/mL) (p < 0.001). Renalase was positively correlated with serum creatinine and dialysis vintage (r = 0.677, p < 0.001 and r = 0.625, p < 0.001, respectively).
  
  
  CONCLUSIONS
  In our study, LVMI was correlated with dialysis vintage, residual diuresis, CRP, and hemoglobin. LVMI tends to correlate with renalase and this correlation may be significant in studies with more patient numbers. The main parameters affecting renalase levels are dialysis vintage and serum creatinine.
authors.affiliation: a Department of Nephrology , Diskapi Yildirim Beyazit Education and Research Hospital , Ankara , Turkey ;
authors.forename: Ebru Gok
authors.initials: EG
authors.lastname: Oguz
authors.affiliation: a Department of Nephrology , Diskapi Yildirim Beyazit Education and Research Hospital , Ankara , Turkey ;
authors.forename: Guner Karaveli
authors.initials: GK
authors.lastname: Gursoy
authors.affiliation: a Department of Nephrology , Diskapi Yildirim Beyazit Education and Research Hospital , Ankara , Turkey ;
authors.forename: Ozlem
authors.initials: O
authors.lastname: Yayar
authors.affiliation: a Department of Nephrology , Diskapi Yildirim Beyazit Education and Research Hospital , Ankara , Turkey ;
authors.forename: Tolga
authors.initials: T
authors.lastname: Yildirim
authors.affiliation: b Department of Cardiology , Diskapi Yildirim Beyazit Education and Research Hospital , Ankara , Turkey.
authors.forename: Tolga
authors.initials: T
authors.lastname: Cimen
authors.affiliation: a Department of Nephrology , Diskapi Yildirim Beyazit Education and Research Hospital , Ankara , Turkey ;
authors.forename: Cengiz
authors.initials: C
authors.lastname: Bulut
authors.affiliation: a Department of Nephrology , Diskapi Yildirim Beyazit Education and Research Hospital , Ankara , Turkey ;
authors.forename: Barıs
authors.initials: B
authors.lastname: Eser
authors.affiliation: a Department of Nephrology , Diskapi Yildirim Beyazit Education and Research Hospital , Ankara , Turkey ;
authors.forename: Basol
authors.initials: B
authors.lastname: Canbakan
authors.affiliation: b Department of Cardiology , Diskapi Yildirim Beyazit Education and Research Hospital , Ankara , Turkey.
authors.forename: Ekrem
authors.initials: E
authors.lastname: Yeter
authors.affiliation: a Department of Nephrology , Diskapi Yildirim Beyazit Education and Research Hospital , Ankara , Turkey ;
authors.forename: M Deniz
authors.initials: MD
authors.lastname: Ayli
mesh_terms: D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D003404:Creatinine / Q000097:blood; D003430:Cross-Sectional Studies; D018618:Echocardiography, Doppler, Color; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging* / Q000209:etiology; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000097:blood*; D012044:Regression Analysis; D006435:Renal Dialysis; D012307:Risk Factors; D014421:Turkey
chemical_list: D002097:C-Reactive Protein; D003404:Creatinine; D008995:Monoamine Oxidase; C521557:renalase
keywords: C-reactive protein; hemodialysis; left ventricular mass index; renalase; residual diuresis