title: Comparison of the carotenoid compositions and protection of in-season and anti-season tomato extracts against d-galactose-induced cognition deficits and oxidative damage in mice.
abstract: The compositions and contents of carotenoids in in-season and anti-season tomatoes were compared by HPLC method. In-season and anti-season tomatoes differed not only in the contents of all-trans-lycopene and β-carotene but also in the contents of cis-isomers, implying environmental factors affected not only the accumulation of the all-trans-carotenoids but also their cis-isomers. Meanwhile, the protection of in-season and anti-season tomato extracts against d-galactose induced cognition deficits and oxidative damage in mice were studied. The water-soluble extracts of both season tomatoes showed little protecting effects on the impairment in mice induced by D-gal, while the fat-soluble extracts significantly attenuated d-gal-induced cognitive impairment, and prevented the oxidative damage in mice, but no remarkable difference was observed between the two season tomatoes at the same dose levels, indicating anti-season tomatoes showed similar in vivo protection against d-galactose induced cognition deficits and oxidative damage as that of in-season tomatoes.
authors.affiliation: a College of Food Science and Technology , Huazhong Agricultural University , Wuhan , China ;
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: a College of Food Science and Technology , Huazhong Agricultural University , Wuhan , China ;
authors.forename: Huahan
authors.initials: H
authors.lastname: Chen
authors.affiliation: a College of Food Science and Technology , Huazhong Agricultural University , Wuhan , China ;
authors.forename: Wei
authors.initials: W
authors.lastname: Zhu
authors.affiliation: a College of Food Science and Technology , Huazhong Agricultural University , Wuhan , China ;|b Key Laboratory of Environment Correlative Food Science (Huazhong Agricultural University), Ministry of Education , Wuhan , China.
authors.forename: Chunmei
authors.initials: C
authors.lastname: Li
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000032:analysis / Q000378:metabolism / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D002338:Carotenoids / Q000032:analysis* / Q000737:chemistry / Q000494:pharmacology; D003072:Cognition Disorders / Q000139:chemically induced* / Q000517:prevention & control* / Q000523:psychology; D005690:Galactose / Q000633:toxicity*; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology; D018551:Solanum lycopersicum / Q000737:chemistry* / Q000254:growth & development; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D051379:Mice; D018696:Neuroprotective Agents / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology; D012621:Seasons; D013237:Stereoisomerism
chemical_list: D000975:Antioxidants; D018696:Neuroprotective Agents; D010936:Plant Extracts; D002338:Carotenoids; D005690:Galactose
keywords: Tomato; aging; anti-season; carotenoids; natural antioxidants