title: The Pediatric Cerebellum in Inherited Neurodegenerative Disorders: A Pattern-recognition Approach.
abstract: Evaluation of imaging studies of the cerebellum in inherited neurodegenerative disorders is aided by attention to neuroimaging patterns based on anatomic determinants, including biometric analysis, hyperintense signal of structures, including the cerebellar cortex, white matter, dentate nuclei, brainstem tracts, and nuclei, the presence of cysts, brain iron, or calcifications, change over time, the use of diffusion-weighted/diffusion tensor imaging and T2*-weighted sequences, magnetic resonance spectroscopy; and, in rare occurrences, the administration of contrast material.
authors.affiliation: Division of Paediatric Neuroradiology, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada. Electronic address: susan.blaser@sickkids.ca.
authors.forename: Susan I
authors.initials: SI
authors.lastname: Blaser
authors.affiliation: Division of Neuropaediatrics, Development and Rehabilitation, University Children's Hospital Inselspital, University of Bern, Freiburgstrasse 4, Bern 3010, Switzerland.
authors.forename: Maja
authors.initials: M
authors.lastname: Steinlin
authors.affiliation: Department of Genetics, Sultan Qaboos University Hospital, Al Khoudh, Muscat 123, Oman.
authors.forename: Almundher
authors.initials: A
authors.lastname: Al-Maawali
authors.affiliation: Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.
authors.forename: Grace
authors.initials: G
authors.lastname: Yoon
mesh_terms: D002524:Cerebellar Ataxia / Q000150:complications / Q000000981:diagnostic imaging*; D002531:Cerebellum / Q000000981:diagnostic imaging; D002648:Child; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D019636:Neurodegenerative Diseases / Q000150:complications / Q000000981:diagnostic imaging*; D059906:Neuroimaging / Q000379:methods*; D010363:Pattern Recognition, Automated / Q000379:methods*
keywords: Cerebellum; Inborn errors of metabolism; Inherited neurodegenerative disorders