title: Continuous-terahertz-wave molecular imaging system for biomedical applications.
abstract: Molecular imaging techniques are becoming increasingly important in biomedical research and potentially in clinical practice. We present a continuous-terahertz (THz)-wave molecular imaging system for biomedical applications, in which an infrared (IR) laser is integrated into a 0.2-THz reflection-mode continuous-THz-wave imaging system to induce surface plasmon polaritons on the nanoparticles and further improve the intensity of the reflected signal from the water around the nanoparticles. A strong and rapid increment of the reflected THz signal in the nanoparticle solution upon the IR laser irradiation is demonstrated, using either gold or silver nanoparticles. This low-cost, simple, and stable continuous-THz-wave molecular imaging system is suitable for miniaturization and practical imaging applications; in particular, it shows great promise for cancer diagnosis and nanoparticle drug-delivery monitoring.
authors.affiliation: Peking University, College of Engineering, No. 8 YiHeYuan Road, Beijing 100871, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Capital Normal University, Department of Physics, No. 105 XiSanHuan BeiLu, Beijing 100048, China.
authors.forename: Liangliang
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Capital Normal University, Department of Physics, No. 105 XiSanHuan BeiLu, Beijing 100048, China.
authors.forename: Tong
authors.initials: T
authors.lastname: Wu
authors.affiliation: Peking University, Academy for Advanced Interdisciplinary Studies, No. 8 YiHeYuan Road, Beijing 100871, China.
authors.forename: Ruixue
authors.initials: R
authors.lastname: Wang
authors.affiliation: Peking University, Academy for Advanced Interdisciplinary Studies, No. 8 YiHeYuan Road, Beijing 100871, China.
authors.forename: Shasha
authors.initials: S
authors.lastname: Zuo
authors.affiliation: Peking University, Academy for Advanced Interdisciplinary Studies, No. 8 YiHeYuan Road, Beijing 100871, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Wu
authors.affiliation: Capital Normal University, Department of Physics, No. 105 XiSanHuan BeiLu, Beijing 100048, China.
authors.forename: Cunlin
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Peking University, College of Engineering, No. 8 YiHeYuan Road, Beijing 100871, ChinacPeking University, Academy for Advanced Interdisciplinary Studies, No. 8 YiHeYuan Road, Beijing 100871, China.
authors.forename: Jue
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Peking University, College of Engineering, No. 8 YiHeYuan Road, Beijing 100871, ChinacPeking University, Academy for Advanced Interdisciplinary Studies, No. 8 YiHeYuan Road, Beijing 100871, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Fang
mesh_terms: D006046:Gold / Q000737:chemistry; D007834:Lasers; D053768:Metal Nanoparticles / Q000737:chemistry*; D057054:Molecular Imaging / Q000379:methods*; D012834:Silver / Q000737:chemistry; D055069:Terahertz Imaging; D014867:Water / Q000737:chemistry
chemical_list: D014867:Water; D012834:Silver; D006046:Gold