title: Prevalence and Detection of Prescription Opioid Misuse and Prescription Opioid Use Disorder Among Emergency Department Patients 50 Years of Age and Older: Performance of the Prescription Drug Use Questionnaire, Patient Version.
abstract: Despite increased concern about prescription opioid misuse among older adults, there is limited work examining the best means to identify misuse by older adults. The goal of this investigation was to examine the performance the Prescription Drug Use Questionnaire Patient Version (PDUQp), in detecting prescription opioid misuse and prescription opioid use disorders among adult emergency department (ED) patients aged 50 years and older.
  
  
  
  This was a cross-sectional study of a random sample of adult ED patients, aged 50 years and older. All participants were without cognitive impairment and reported prescription opioid use within the past 30 days. We evaluated the sensitivity, specificity, predictive values, and receiver operating characteristics of the PDUQp against a standard definition of opioid misuse and DSM-5 criteria for prescription opioid use disorder.
  
  
  
  Overall, 112 participants completed the study; 74 were aged 50-64 years and 38 were aged 65 years and older. Over half of the participants satisfied DSM-5 criteria for prescription opioid use disorder, with slightly less participants reporting misuse. Overall, the respective sensitivity and specificity of the PDUQp was: 44% and 79% (Receiver Operating Characteristic [ROC] area under the curve: 0.61) for prescription opioid misuse, 38% and 81% (ROC area under the curve: 0.64) for the presence of any prescription opioid use disorder, and 56% and 75% (ROC area under the curve: 0.71) for moderate to severe prescription opioid use disorder.
  
  
  
  Based on this preliminary work, the PDUQp may be a viable instrument to screen for prescription opioid misuse and prescription opioid use disorder, but it likely requires modifications to optimize its predictive ability in adults over age 50 years.
authors.affiliation: Department of Emergency Medicine, Alpert Medical School of Brown University, Providence, RI, USA. Electronic address: francesca_beaudoin@brown.edu.
authors.forename: Francesca L
authors.initials: FL
authors.lastname: Beaudoin
authors.affiliation: Department of Emergency Medicine, Alpert Medical School of Brown University, Providence, RI, USA; Department of Epidemiology, School of Public Health, Brown University, Providence, RI, USA.
authors.forename: Roland C
authors.initials: RC
authors.lastname: Merchant
authors.affiliation: Department of Epidemiology, School of Public Health, Brown University, Providence, RI, USA.
authors.forename: Melissa A
authors.initials: MA
authors.lastname: Clark
mesh_terms: D000368:Aged; D000701:Analgesics, Opioid / Q000009:adverse effects*; D059350:Chronic Pain / Q000188:drug therapy; D003430:Cross-Sectional Studies; D004636:Emergency Service, Hospital / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009293:Opioid-Related Disorders / Q000175:diagnosis* / Q000453:epidemiology*; D063487:Prescription Drug Misuse / Q000706:statistics & numerical data*; D012372:ROC Curve; D012237:Rhode Island; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires
chemical_list: D000701:Analgesics, Opioid
keywords: Drug use disorder; Emergency department; Older adults; Prescription opioid misuse; Prescription opioid use disorder; Prescription opioids; Screening; Substance abuse