title: Hyperbaric oxygen therapy in tinnitus with normal hearing in association with combined treatment.
abstract: Tinnitus is a phantom perception of sound in the absence of overt acoustic stimulation. The focus of our attention is a combined therapy of tinnitus. In this prospective study (2013-2014) we evaluated the data of normal-hearing patients with tinnitus treated with various treatment modalities. In Group 1 we evaluated the data of 84 patients/124 ears after six weeks of treatment with betahistine dihydrochloride (72 mg). In Group 2, we evaluated the data of 36 patients/ 55 ears unimproved from Group 1 who were then treated for six weeks with hyperbaric oxygen (HBO₂) therapy combined with gingko biloba extract (120 mg). In Group 1, tinnitus disappeared in 9.7%, alleviated in 18.5% and improved overall in 28.2%. Average intensity of tinnitus before/after treatment was 37 decibels (dB)/33 dB. Tinnitus intensities after treatment are statistically significantly lower (p = 0.001) than the values before treatment. In Group 2 tinnitus disappeared in 5.4%, 36.4% achieved alleviation, and 41.8% showed overall improvement. The average intensity of tinnitus before/after treatment was 41dB/ 38dB. The values of tinnitus intensity after combined therapy are statistically significantly lower (p = 0.046). We have shown that both methods treatment of tinnitus are statistically significant. HBO₂therapy was recommended for the general public.
authors.forename: Richard
authors.initials: R
authors.lastname: Holy
authors.forename: Pavol
authors.initials: P
authors.lastname: Prazenica
authors.forename: Eva
authors.initials: E
authors.lastname: Stolarikova
authors.forename: Petr
authors.initials: P
authors.lastname: Dosel
authors.forename: Petra
authors.initials: P
authors.lastname: Fundova
authors.forename: Daniel
authors.initials: D
authors.lastname: Kovar
authors.forename: Jaromir
authors.initials: J
authors.lastname: Astl
mesh_terms: D000328:Adult; D000368:Aged; D001621:Betahistine / Q000627:therapeutic use*; D003131:Combined Modality Therapy / Q000379:methods; D005260:Female; D020441:Ginkgo biloba; D006309:Hearing; D006801:Humans; D006931:Hyperbaric Oxygenation; D008297:Male; D008875:Middle Aged; D010936:Plant Extracts / Q000627:therapeutic use*; D011446:Prospective Studies; D012720:Severity of Illness Index; D014012:Tinnitus / Q000628:therapy*; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D010936:Plant Extracts; D014665:Vasodilator Agents; D001621:Betahistine