title: Is there a difference in clinicopathological outcomes of renal tumor between young and old patients? A multicenter matched-pair analysis.
abstract: OBJECTIVE
  The aim of this study was to investigate the influence of age at diagnosis on tumor characteristics and cancer-specific survival (CSS) in renal cell carcinoma (RCC).
  
  
  METHODS
  Data of patients who underwent radical or partial nephrectomy for renal tumor between 2003 and 2011 at multiple institutions were collected. Patients were divided into two groups according to age at diagnosis: 20-39 years and 40-79 years. To adjust for potential baseline confounders, propensity score matching was performed.
  
  
  RESULTS
  All included data showed that young RCC patients presented with renal tumors that had a more favorable histological subtype, were localized, smaller in size, and had a lower Fuhrman nuclear grade. The 5 year CSS rates were 95.5% and 90.5% in the young and old patient groups, respectively (log rank p = 0.019). After matching on the propensity score, the two groups with RCC had 302 patients each. Because the groups were matched on covariates, there were no significant differences in the pathological proportion, tumor size, Fuhrman nuclear grade and clinical T stage. The 5 year CSS rates were 95.5% and 94.7% in the young and old patient groups, respectively (log rank p = 0.184).
  
  
  CONCLUSIONS
  After adjusting for potential biases, there was no significant difference in prognosis between young and old patients with RCC.
authors.affiliation: a Department of Urology , Dongnam Institute of Radiological & Medical Sciences, Cancer Center , Busan , Republic of Korea ;
authors.forename: Jeong Ho
authors.initials: JH
authors.lastname: Kim
authors.affiliation: b Department of Urology , Seoul St. Mary's Hospital, College of Medicine, the Catholic University of Korea , Seoul , Republic of Korea ;
authors.forename: Yong Hyun
authors.initials: YH
authors.lastname: Park
authors.affiliation: c Department of Urology , Chungbuk National University College of Medicine , Cheongju , Republic of Korea ;
authors.forename: Yong June
authors.initials: YJ
authors.lastname: Kim
authors.affiliation: d Department of Urology , Korea University School of Medicine , Seoul , Republic of Korea ;
authors.forename: Seok Ho
authors.initials: SH
authors.lastname: Kang
authors.affiliation: e Department of Urology , Seoul National University Bundang Hospital , Seongnam , Republic of Korea.
authors.forename: Seok Soo
authors.initials: SS
authors.lastname: Byun
authors.affiliation: b Department of Urology , Seoul St. Mary's Hospital, College of Medicine, the Catholic University of Korea , Seoul , Republic of Korea ;
authors.forename: Sung-Hoo
authors.initials: SH
authors.lastname: Hong
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000401:mortality* / Q000601:surgery*; D006801:Humans; D007680:Kidney Neoplasms / Q000401:mortality* / Q000601:surgery*; D016555:Matched-Pair Analysis; D008875:Middle Aged; D009392:Nephrectomy; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome
keywords: Age groups; carcinoma; kidney; renal cell; survival