title: Interleukin 31 is involved in intrahepatic cholestasis of pregnancy.
abstract: Intrahepatic cholestasis of pregnancy (ICP) is a liver disorder characterized by maternal itching and altered liver function. Interleukin (IL)-31 is known to be involved in the pathogenesis of pruritic inflammatory skin diseases. In a three-year period, 13 women with a singleton pregnancy and a diagnosis of intrahepatic cholestasis (ICP) were enrolled together with 26 healthy single pregnant women who concluded an uncomplicated pregnancy. The inclusion criteria were itching and elevated levels of liver transaminases. Median serum levels of IL-31 were significantly higher in ICP patients than in the control group (p = 0.004). Furthermore, IL-31 values were directly dependent on liver transaminase levels.
authors.affiliation: a Department of Human Pathology and Development and.
authors.forename: F
authors.initials: F
authors.lastname: Basile
authors.affiliation: a Department of Human Pathology and Development and.
authors.forename: A
authors.initials: A
authors.lastname: Santamaria
authors.affiliation: b Department of Clinical and Experimental Medicine , University of Messina , Messina , Italy.
authors.forename: C
authors.initials: C
authors.lastname: Mannucci
authors.affiliation: a Department of Human Pathology and Development and.
authors.forename: L
authors.initials: L
authors.lastname: Rizzo
authors.affiliation: b Department of Clinical and Experimental Medicine , University of Messina , Messina , Italy.
authors.forename: S
authors.initials: S
authors.lastname: Gangemi
authors.affiliation: a Department of Human Pathology and Development and.
authors.forename: R
authors.initials: R
authors.lastname: D'anna
authors.affiliation: b Department of Clinical and Experimental Medicine , University of Messina , Messina , Italy.
authors.forename: V
authors.initials: V
authors.lastname: Arcoraci
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002780:Cholestasis, Intrahepatic / Q000097:blood* / Q000503:physiopathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007378:Interleukins / Q000097:blood*; D016014:Linear Models; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood* / Q000503:physiopathology; D011537:Pruritus / Q000209:etiology
chemical_list: C502187:IL31 protein, human; D007378:Interleukins
keywords: Cytokines; interleukin 31; intrahepatic cholestasis of pregnancy; liver transaminases