title: Intolerance of Uncertainty Predicts Anxiety Outcomes Following CBT in Youth with ASD.
abstract: Modified cognitive-behavioral therapy (MCBT) has been demonstrated to reduce anxiety in youth with autism spectrum disorder (ASD). However, non-response rates are fairly high. Few studies have investigated factors associated with response. Intolerance of uncertainty (IU) is a treatment target for anxiety and worry in neurotypical populations and has been linked to anxiety and ASD. We sought to examine whether IU affects outcomes following MCBT in 43 children, ages 8-14 years, with ASD without intellectual disability. Consistent with prior data, there was a significant reduction in parent reported anxiety following MCBT. Higher levels of pre-intervention IU predicted higher anxiety and worry pre- and post-intervention. These findings suggest that targeting IU may improve outcomes following MCBT in youth with ASD and anxiety.
authors.affiliation: Center for Autism and Related Disorder, Kennedy Krieger Institute, Baltimore, MD, 21286, USA. keefer@kennedykrieger.org.|Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA. keefer@kennedykrieger.org.
authors.forename: Amy
authors.identifier: http://orcid.org/0000-0001-6931-0232
authors.initials: A
authors.lastname: Keefer
authors.affiliation: Center for Autism and Related Disorder, Kennedy Krieger Institute, Baltimore, MD, 21286, USA.|Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Nicole L
authors.initials: NL
authors.lastname: Kreiser
authors.affiliation: Center for Autism and Related Disorder, Kennedy Krieger Institute, Baltimore, MD, 21286, USA.
authors.forename: Vini
authors.initials: V
authors.lastname: Singh
authors.affiliation: University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA.
authors.forename: Audrey
authors.initials: A
authors.lastname: Blakeley-Smith
authors.affiliation: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
authors.forename: Amie
authors.initials: A
authors.lastname: Duncan
authors.affiliation: Center for Autism and Related Disorder, Kennedy Krieger Institute, Baltimore, MD, 21286, USA.
authors.forename: Catherine
authors.initials: C
authors.lastname: Johnson
authors.affiliation: TEACCH Autism Program, Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
authors.forename: Laura
authors.initials: L
authors.lastname: Klinger
authors.affiliation: TEACCH Autism Program, Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
authors.forename: Allison
authors.initials: A
authors.lastname: Meyer
authors.affiliation: University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA.
authors.forename: Judy
authors.initials: J
authors.lastname: Reaven
authors.affiliation: Center for Autism and Related Disorder, Kennedy Krieger Institute, Baltimore, MD, 21286, USA.|Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Roma A
authors.initials: RA
authors.lastname: Vasa
mesh_terms: D000293:Adolescent; D001007:Anxiety / Q000523:psychology / Q000628:therapy*; D000067877:Autism Spectrum Disorder / Q000523:psychology / Q000628:therapy*; D002648:Child; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D016896:Treatment Outcome; D035501:Uncertainty
keywords: Anxiety; Autism spectrum disorders; Cognitive–behavioral therapy; Intolerance of uncertainty