title: N-terminal pro b-type natriuretic peptide (NT-pro-BNP) -based score can predict in-hospital mortality in patients with heart failure.
abstract: Serum N-terminal pro b-type natriuretic peptide (NT-pro-BNP) testing is recommended in the patients with heart failure (HF). We hypothesized that NT-pro-BNP, in combination with other clinical factors in terms of a novel NT-pro BNP-based score, may provide even better predictive power for in-hospital mortality among patients with HF. A retrospective study enrolled adult patients with hospitalization-requiring HF who fulfilled the predefined criteria during the period from January 2011 to December 2013. We proposed a novel scoring system consisting of several independent predictors including NT-pro-BNP for predicting in-hospital mortality, and then compared the prognosis-predictive power of the novel NT-pro BNP-based score with other prognosis-predictive scores. A total of 269 patients were enrolled in the current study. Factors such as "serum NT-pro-BNP level above 8100 mg/dl," "age above 79 years," "without taking angiotensin converting enzyme inhibitors/angiotensin receptor blocker," "without taking beta-blocker," "without taking loop diuretics," "with mechanical ventilator support," "with non-invasive ventilator support," "with vasopressors use," and "experience of cardio-pulmonary resuscitation" were found as independent predictors. A novel NT-pro BNP-based score composed of these risk factors was proposed with excellent predictability for in-hospital mortality. The proposed novel NT-pro BNP-based score was extremely effective in predicting in-hospital mortality in HF patients.
authors.affiliation: Doctoral Candidate, Graduate Institute of Clinical Medical Science, College of Medicine, Chang Gung University. No. 259, Wenhua 1st Rd., Guishan Dist., Taoyuan City 33302, Taiwan, R.O.C.|Department of Nursing, Department of Surgery, Saint Mary's Hospital Luodong. No. 160, Zhongheng S. Rd., Luodong, Yilan 26546, Taiwan, R.O.C.
authors.forename: Ya-Ting
authors.initials: YT
authors.lastname: Huang
authors.affiliation: Division of Cardiovascular Medicine, Department of Internal Medicine, Saint Mary's Hospital Luodong. No. 160, Zhongheng S. Rd., Luodong, Yilan 26546, Taiwan, R.O.C.
authors.forename: Yuan-Teng
authors.initials: YT
authors.lastname: Tseng
authors.affiliation: Division of Cardiovascular Surgery, Department of Surgery, Saint Mary's Hospital Luodong. No. 160, Zhongheng S. Rd., Luodong, Yilan 26546, Taiwan, R.O.C.
authors.forename: Tung-Wei
authors.initials: TW
authors.lastname: Chu
authors.affiliation: Division of Cardiovascular Medicine, Department of Internal Medicine, Saint Mary's Hospital Luodong. No. 160, Zhongheng S. Rd., Luodong, Yilan 26546, Taiwan, R.O.C.
authors.forename: John
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Nursing, Department of Surgery, Saint Mary's Hospital Luodong. No. 160, Zhongheng S. Rd., Luodong, Yilan 26546, Taiwan, R.O.C.
authors.forename: Min-Yu
authors.initials: MY
authors.lastname: Lai
authors.affiliation: Graduate Institute of Nursing, Chang Gung University, Taiwan 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan, Taiwan, ROC.
authors.forename: Woung-Ru
authors.initials: WR
authors.lastname: Tang
authors.affiliation: Division of Nephrology in Department of Internal Medicine, Department of Surgery, Saint Mary's Hospital Luodong. No. 160, Zhongheng S. Rd., Luodong, Yilan 26546, Taiwan, R.O.C.|Saint Mary’s Junior College of Medicine, Nursing and Management. No. 100, Ln. 265, Sec. 2, Sanxing Rd., Sanxing Township, Yilan County 266, Taiwan, R.O.C.
authors.forename: Chih-Chung
authors.initials: CC
authors.lastname: Shiao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000175:diagnosis* / Q000401:mortality*; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D012189:Retrospective Studies; D012307:Risk Factors; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain