title: Exploring the contribution of maternal antibiotics and breastfeeding to development of the infant microbiome and pediatric obesity.
abstract: Pediatric obesity, a significant public health concern, has been associated with adult premature mortality and the development of type 2 diabetes and cardiovascular disease. Evidence has suggested that the gut microbiota is associated with pediatric obesity. Establishment of the infant gut microbiome is dependent on a dynamic maternal-infant microbiota exchange during early life. The objective of this review is to describe maternal factors such as feeding practices and antibiotic use that may influence the infant gut microbiome and risk for obesity. The complex components in human milk have many nutritional benefits to the infant; however, the microbiome in human milk may be an important factor to help regulate the infant's weight. We discuss maternal antibiotics and the effects on breast milk as critical exposures that alter the infant's gut microbiome and influence the risk of pediatric obesity.
authors.affiliation: University of Florida, Department of Health Outcomes and Policy, Gainesville, FL, USA. Electronic address: djlemas@ufl.edu.
authors.forename: Dominick J
authors.initials: DJ
authors.lastname: Lemas
authors.affiliation: University of Florida, Department of Health Outcomes and Policy, Gainesville, FL, USA.
authors.forename: Shanique
authors.initials: S
authors.lastname: Yee
authors.affiliation: University of Florida, Department of Pediatrics, Division of Neonatology, Gainesville, FL, USA.
authors.forename: Nicole
authors.initials: N
authors.lastname: Cacho
authors.affiliation: University of Florida, Department of Health Outcomes and Policy, Gainesville, FL, USA.
authors.forename: Darci
authors.initials: D
authors.lastname: Miller
authors.affiliation: University of Florida, Department of Health Outcomes and Policy, Gainesville, FL, USA.
authors.forename: Michelle
authors.initials: M
authors.lastname: Cardel
authors.affiliation: University of Florida, Department of Health Outcomes and Policy, Gainesville, FL, USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: Gurka
authors.affiliation: University of Florida, Department of Clinical and Health Psychology, Gainesville, FL, USA.
authors.forename: David
authors.initials: D
authors.lastname: Janicke
authors.affiliation: University of Florida, Department of Health Outcomes and Policy, Gainesville, FL, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Shenkman
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001942:Breast Feeding; D005260:Female; D006801:Humans; D007223:Infant; D064307:Microbiota; D008895:Milk, Human / Q000382:microbiology*; D063766:Pediatric Obesity / Q000382:microbiology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
chemical_list: D000900:Anti-Bacterial Agents
keywords: Antibiotics; Bifidobacterium; Breast milk; Breastfeeding; Human milk; Infant gut microbiome; Pediatric obesity