title: Myelodysplasia Following Treatment of Chronic Lymphocytic Leukaemia with Fludarabine.
abstract: Recently there has been an increased awareness of a possible link between the use of purine nucleoside analogues and myelodysplasia. We report the case of a patient who developed myelodysplasia with complex cytogenetic changes after receiving fludarabine. We review the literature, discuss the possible links between myelodysplasia and nucleoside analogues and putative mechanisms for secondary neoplasia.
authors.affiliation: a Dept. of Haematology , Royal Free Hospital , London NW32QG.
authors.forename: B J
authors.initials: BJ
authors.lastname: Hennessy
authors.affiliation: b Kennedy-Galton Cytogenetics Centre , Northwick Park Hospital , Harrow HA13UJ.
authors.forename: S
authors.initials: S
authors.lastname: Ryley
authors.affiliation: c Dept. of Cytogenetics , Royal Free Hospital , London NW32QG.
authors.forename: A
authors.initials: A
authors.lastname: Kasprzyk
authors.affiliation: a Dept. of Haematology , Royal Free Hospital , London NW32QG.
authors.forename: C D
authors.initials: CD
authors.lastname: Reid
keywords: CLL; Purine analogues; cytogenetics; fludarabine; myelodysplasia