title: Spanish Validation of the Problem Behaviors Assessment-Short (PBA-s) for Huntington's Disease.
abstract: A prospective, observational multicenter study was carried out assessing neuropsychiatric symptoms in a sample of 117 subjects in order to validate the Spanish version of the Problem Behaviors Assessment-Short (PBA-s). The psychometric properties of this version were analyzed. Inter- and intra-rater reliability were good: the mean weighted Cohen's kappa was 0.90 for severity scores and 0.93 for frequency scores. Four factors accounting for 56% of the total variance were identified after an exploratory factor analysis: apathy, irritability, depression, and perseveration. The PBA-s correlates strongly with the Neuropsychiatric Inventory, demonstrating its accuracy for assessing neuropsychiatric symptoms in patients with Huntington's disease.
authors.affiliation: From the Huntington Disease Programme, Hospital Mare de Déu de la Mercè, Hermanas Hospitalarias, Barcelona, Spain (JR-I, MF, PR); the FIDMAG Hermanas Hospitalarias Research Foundation, Barcelona, Spain (RS, EP-C, SS); the Programa de Doctorat de Psiquiatria, Universitat Autònoma de Barcelona, Barcelona, Spain (JR-I); the CIBERSAM, Instituto de Salud Carlos III, Madrid, Spain (RS, EP-C, SS); the Neurology Department, Hospital Ramón y Cajal, Madrid, Spain (JL-S, VM); the Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain (JL-S, VM); the CIBERNED, Instituto de Salud Carlos III, Madrid, Spain (JL-S); the Neurology Department, Complejo Asistencial Universitario Burgos, Burgos (EB), Spain; the Neurology Department, Movement Disorders Unit, Fundació Clinic per la Recerca Biomèdica, Barcelona, Spain (EM, PS, LV); and the Dementia Unit, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain (MN).
authors.forename: Jesús M
authors.initials: JM
authors.lastname: Ruiz-Idiago
authors.affiliation: From the Huntington Disease Programme, Hospital Mare de Déu de la Mercè, Hermanas Hospitalarias, Barcelona, Spain (JR-I, MF, PR); the FIDMAG Hermanas Hospitalarias Research Foundation, Barcelona, Spain (RS, EP-C, SS); the Programa de Doctorat de Psiquiatria, Universitat Autònoma de Barcelona, Barcelona, Spain (JR-I); the CIBERSAM, Instituto de Salud Carlos III, Madrid, Spain (RS, EP-C, SS); the Neurology Department, Hospital Ramón y Cajal, Madrid, Spain (JL-S, VM); the Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain (JL-S, VM); the CIBERNED, Instituto de Salud Carlos III, Madrid, Spain (JL-S); the Neurology Department, Complejo Asistencial Universitario Burgos, Burgos (EB), Spain; the Neurology Department, Movement Disorders Unit, Fundació Clinic per la Recerca Biomèdica, Barcelona, Spain (EM, PS, LV); and the Dementia Unit, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain (MN).
authors.forename: Misericordia
authors.initials: M
authors.lastname: Floriach
authors.affiliation: From the Huntington Disease Programme, Hospital Mare de Déu de la Mercè, Hermanas Hospitalarias, Barcelona, Spain (JR-I, MF, PR); the FIDMAG Hermanas Hospitalarias Research Foundation, Barcelona, Spain (RS, EP-C, SS); the Programa de Doctorat de Psiquiatria, Universitat Autònoma de Barcelona, Barcelona, Spain (JR-I); the CIBERSAM, Instituto de Salud Carlos III, Madrid, Spain (RS, EP-C, SS); the Neurology Department, Hospital Ramón y Cajal, Madrid, Spain (JL-S, VM); the Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain (JL-S, VM); the CIBERNED, Instituto de Salud Carlos III, Madrid, Spain (JL-S); the Neurology Department, Complejo Asistencial Universitario Burgos, Burgos (EB), Spain; the Neurology Department, Movement Disorders Unit, Fundació Clinic per la Recerca Biomèdica, Barcelona, Spain (EM, PS, LV); and the Dementia Unit, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain (MN).
authors.forename: Cèlia
authors.initials: C
authors.lastname: Mareca
authors.affiliation: From the Huntington Disease Programme, Hospital Mare de Déu de la Mercè, Hermanas Hospitalarias, Barcelona, Spain (JR-I, MF, PR); the FIDMAG Hermanas Hospitalarias Research Foundation, Barcelona, Spain (RS, EP-C, SS); the Programa de Doctorat de Psiquiatria, Universitat Autònoma de Barcelona, Barcelona, Spain (JR-I); the CIBERSAM, Instituto de Salud Carlos III, Madrid, Spain (RS, EP-C, SS); the Neurology Department, Hospital Ramón y Cajal, Madrid, Spain (JL-S, VM); the Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain (JL-S, VM); the CIBERNED, Instituto de Salud Carlos III, Madrid, Spain (JL-S); the Neurology Department, Complejo Asistencial Universitario Burgos, Burgos (EB), Spain; the Neurology Department, Movement Disorders Unit, Fundació Clinic per la Recerca Biomèdica, Barcelona, Spain (EM, PS, LV); and the Dementia Unit, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain (MN).
authors.forename: Raymond
authors.initials: R
authors.lastname: Salvador
authors.affiliation: From the Huntington Disease Programme, Hospital Mare de Déu de la Mercè, Hermanas Hospitalarias, Barcelona, Spain (JR-I, MF, PR); the FIDMAG Hermanas Hospitalarias Research Foundation, Barcelona, Spain (RS, EP-C, SS); the Programa de Doctorat de Psiquiatria, Universitat Autònoma de Barcelona, Barcelona, Spain (JR-I); the CIBERSAM, Instituto de Salud Carlos III, Madrid, Spain (RS, EP-C, SS); the Neurology Department, Hospital Ramón y Cajal, Madrid, Spain (JL-S, VM); the Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain (JL-S, VM); the CIBERNED, Instituto de Salud Carlos III, Madrid, Spain (JL-S); the Neurology Department, Complejo Asistencial Universitario Burgos, Burgos (EB), Spain; the Neurology Department, Movement Disorders Unit, Fundació Clinic per la Recerca Biomèdica, Barcelona, Spain (EM, PS, LV); and the Dementia Unit, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain (MN).
authors.forename: José Luis
authors.initials: JL
authors.lastname: López-Sendón
authors.affiliation: From the Huntington Disease Programme, Hospital Mare de Déu de la Mercè, Hermanas Hospitalarias, Barcelona, Spain (JR-I, MF, PR); the FIDMAG Hermanas Hospitalarias Research Foundation, Barcelona, Spain (RS, EP-C, SS); the Programa de Doctorat de Psiquiatria, Universitat Autònoma de Barcelona, Barcelona, Spain (JR-I); the CIBERSAM, Instituto de Salud Carlos III, Madrid, Spain (RS, EP-C, SS); the Neurology Department, Hospital Ramón y Cajal, Madrid, Spain (JL-S, VM); the Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain (JL-S, VM); the CIBERNED, Instituto de Salud Carlos III, Madrid, Spain (JL-S); the Neurology Department, Complejo Asistencial Universitario Burgos, Burgos (EB), Spain; the Neurology Department, Movement Disorders Unit, Fundació Clinic per la Recerca Biomèdica, Barcelona, Spain (EM, PS, LV); and the Dementia Unit, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain (MN).
authors.forename: Verónica
authors.initials: V
authors.lastname: Mañanés
authors.affiliation: From the Huntington Disease Programme, Hospital Mare de Déu de la Mercè, Hermanas Hospitalarias, Barcelona, Spain (JR-I, MF, PR); the FIDMAG Hermanas Hospitalarias Research Foundation, Barcelona, Spain (RS, EP-C, SS); the Programa de Doctorat de Psiquiatria, Universitat Autònoma de Barcelona, Barcelona, Spain (JR-I); the CIBERSAM, Instituto de Salud Carlos III, Madrid, Spain (RS, EP-C, SS); the Neurology Department, Hospital Ramón y Cajal, Madrid, Spain (JL-S, VM); the Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain (JL-S, VM); the CIBERNED, Instituto de Salud Carlos III, Madrid, Spain (JL-S); the Neurology Department, Complejo Asistencial Universitario Burgos, Burgos (EB), Spain; the Neurology Department, Movement Disorders Unit, Fundació Clinic per la Recerca Biomèdica, Barcelona, Spain (EM, PS, LV); and the Dementia Unit, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain (MN).
authors.forename: Esther
authors.initials: E
authors.lastname: Cubo
authors.affiliation: From the Huntington Disease Programme, Hospital Mare de Déu de la Mercè, Hermanas Hospitalarias, Barcelona, Spain (JR-I, MF, PR); the FIDMAG Hermanas Hospitalarias Research Foundation, Barcelona, Spain (RS, EP-C, SS); the Programa de Doctorat de Psiquiatria, Universitat Autònoma de Barcelona, Barcelona, Spain (JR-I); the CIBERSAM, Instituto de Salud Carlos III, Madrid, Spain (RS, EP-C, SS); the Neurology Department, Hospital Ramón y Cajal, Madrid, Spain (JL-S, VM); the Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain (JL-S, VM); the CIBERNED, Instituto de Salud Carlos III, Madrid, Spain (JL-S); the Neurology Department, Complejo Asistencial Universitario Burgos, Burgos (EB), Spain; the Neurology Department, Movement Disorders Unit, Fundació Clinic per la Recerca Biomèdica, Barcelona, Spain (EM, PS, LV); and the Dementia Unit, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain (MN).
authors.forename: Natividad
authors.initials: N
authors.lastname: Mariscal
authors.affiliation: From the Huntington Disease Programme, Hospital Mare de Déu de la Mercè, Hermanas Hospitalarias, Barcelona, Spain (JR-I, MF, PR); the FIDMAG Hermanas Hospitalarias Research Foundation, Barcelona, Spain (RS, EP-C, SS); the Programa de Doctorat de Psiquiatria, Universitat Autònoma de Barcelona, Barcelona, Spain (JR-I); the CIBERSAM, Instituto de Salud Carlos III, Madrid, Spain (RS, EP-C, SS); the Neurology Department, Hospital Ramón y Cajal, Madrid, Spain (JL-S, VM); the Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain (JL-S, VM); the CIBERNED, Instituto de Salud Carlos III, Madrid, Spain (JL-S); the Neurology Department, Complejo Asistencial Universitario Burgos, Burgos (EB), Spain; the Neurology Department, Movement Disorders Unit, Fundació Clinic per la Recerca Biomèdica, Barcelona, Spain (EM, PS, LV); and the Dementia Unit, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain (MN).
authors.forename: Esteban
authors.initials: E
authors.lastname: Muñoz
authors.affiliation: From the Huntington Disease Programme, Hospital Mare de Déu de la Mercè, Hermanas Hospitalarias, Barcelona, Spain (JR-I, MF, PR); the FIDMAG Hermanas Hospitalarias Research Foundation, Barcelona, Spain (RS, EP-C, SS); the Programa de Doctorat de Psiquiatria, Universitat Autònoma de Barcelona, Barcelona, Spain (JR-I); the CIBERSAM, Instituto de Salud Carlos III, Madrid, Spain (RS, EP-C, SS); the Neurology Department, Hospital Ramón y Cajal, Madrid, Spain (JL-S, VM); the Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain (JL-S, VM); the CIBERNED, Instituto de Salud Carlos III, Madrid, Spain (JL-S); the Neurology Department, Complejo Asistencial Universitario Burgos, Burgos (EB), Spain; the Neurology Department, Movement Disorders Unit, Fundació Clinic per la Recerca Biomèdica, Barcelona, Spain (EM, PS, LV); and the Dementia Unit, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain (MN).
authors.forename: Pilar
authors.initials: P
authors.lastname: Santacruz
authors.affiliation: From the Huntington Disease Programme, Hospital Mare de Déu de la Mercè, Hermanas Hospitalarias, Barcelona, Spain (JR-I, MF, PR); the FIDMAG Hermanas Hospitalarias Research Foundation, Barcelona, Spain (RS, EP-C, SS); the Programa de Doctorat de Psiquiatria, Universitat Autònoma de Barcelona, Barcelona, Spain (JR-I); the CIBERSAM, Instituto de Salud Carlos III, Madrid, Spain (RS, EP-C, SS); the Neurology Department, Hospital Ramón y Cajal, Madrid, Spain (JL-S, VM); the Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain (JL-S, VM); the CIBERNED, Instituto de Salud Carlos III, Madrid, Spain (JL-S); the Neurology Department, Complejo Asistencial Universitario Burgos, Burgos (EB), Spain; the Neurology Department, Movement Disorders Unit, Fundació Clinic per la Recerca Biomèdica, Barcelona, Spain (EM, PS, LV); and the Dementia Unit, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain (MN).
authors.forename: María F
authors.initials: MF
authors.lastname: Noguera
authors.affiliation: From the Huntington Disease Programme, Hospital Mare de Déu de la Mercè, Hermanas Hospitalarias, Barcelona, Spain (JR-I, MF, PR); the FIDMAG Hermanas Hospitalarias Research Foundation, Barcelona, Spain (RS, EP-C, SS); the Programa de Doctorat de Psiquiatria, Universitat Autònoma de Barcelona, Barcelona, Spain (JR-I); the CIBERSAM, Instituto de Salud Carlos III, Madrid, Spain (RS, EP-C, SS); the Neurology Department, Hospital Ramón y Cajal, Madrid, Spain (JL-S, VM); the Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain (JL-S, VM); the CIBERNED, Instituto de Salud Carlos III, Madrid, Spain (JL-S); the Neurology Department, Complejo Asistencial Universitario Burgos, Burgos (EB), Spain; the Neurology Department, Movement Disorders Unit, Fundació Clinic per la Recerca Biomèdica, Barcelona, Spain (EM, PS, LV); and the Dementia Unit, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain (MN).
authors.forename: Laura
authors.initials: L
authors.lastname: Vivancos
authors.affiliation: From the Huntington Disease Programme, Hospital Mare de Déu de la Mercè, Hermanas Hospitalarias, Barcelona, Spain (JR-I, MF, PR); the FIDMAG Hermanas Hospitalarias Research Foundation, Barcelona, Spain (RS, EP-C, SS); the Programa de Doctorat de Psiquiatria, Universitat Autònoma de Barcelona, Barcelona, Spain (JR-I); the CIBERSAM, Instituto de Salud Carlos III, Madrid, Spain (RS, EP-C, SS); the Neurology Department, Hospital Ramón y Cajal, Madrid, Spain (JL-S, VM); the Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain (JL-S, VM); the CIBERNED, Instituto de Salud Carlos III, Madrid, Spain (JL-S); the Neurology Department, Complejo Asistencial Universitario Burgos, Burgos (EB), Spain; the Neurology Department, Movement Disorders Unit, Fundació Clinic per la Recerca Biomèdica, Barcelona, Spain (EM, PS, LV); and the Dementia Unit, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain (MN).
authors.forename: Pedro
authors.initials: P
authors.lastname: Roy
authors.affiliation: From the Huntington Disease Programme, Hospital Mare de Déu de la Mercè, Hermanas Hospitalarias, Barcelona, Spain (JR-I, MF, PR); the FIDMAG Hermanas Hospitalarias Research Foundation, Barcelona, Spain (RS, EP-C, SS); the Programa de Doctorat de Psiquiatria, Universitat Autònoma de Barcelona, Barcelona, Spain (JR-I); the CIBERSAM, Instituto de Salud Carlos III, Madrid, Spain (RS, EP-C, SS); the Neurology Department, Hospital Ramón y Cajal, Madrid, Spain (JL-S, VM); the Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain (JL-S, VM); the CIBERNED, Instituto de Salud Carlos III, Madrid, Spain (JL-S); the Neurology Department, Complejo Asistencial Universitario Burgos, Burgos (EB), Spain; the Neurology Department, Movement Disorders Unit, Fundació Clinic per la Recerca Biomèdica, Barcelona, Spain (EM, PS, LV); and the Dementia Unit, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain (MN).
authors.forename: Edith
authors.initials: E
authors.lastname: Pomarol-Clotet
authors.affiliation: From the Huntington Disease Programme, Hospital Mare de Déu de la Mercè, Hermanas Hospitalarias, Barcelona, Spain (JR-I, MF, PR); the FIDMAG Hermanas Hospitalarias Research Foundation, Barcelona, Spain (RS, EP-C, SS); the Programa de Doctorat de Psiquiatria, Universitat Autònoma de Barcelona, Barcelona, Spain (JR-I); the CIBERSAM, Instituto de Salud Carlos III, Madrid, Spain (RS, EP-C, SS); the Neurology Department, Hospital Ramón y Cajal, Madrid, Spain (JL-S, VM); the Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain (JL-S, VM); the CIBERNED, Instituto de Salud Carlos III, Madrid, Spain (JL-S); the Neurology Department, Complejo Asistencial Universitario Burgos, Burgos (EB), Spain; the Neurology Department, Movement Disorders Unit, Fundació Clinic per la Recerca Biomèdica, Barcelona, Spain (EM, PS, LV); and the Dementia Unit, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain (MN).
authors.forename: Salvador
authors.initials: S
authors.lastname: Sarró
authors.affiliation: From the Huntington Disease Programme, Hospital Mare de Déu de la Mercè, Hermanas Hospitalarias, Barcelona, Spain (JR-I, MF, PR); the FIDMAG Hermanas Hospitalarias Research Foundation, Barcelona, Spain (RS, EP-C, SS); the Programa de Doctorat de Psiquiatria, Universitat Autònoma de Barcelona, Barcelona, Spain (JR-I); the CIBERSAM, Instituto de Salud Carlos III, Madrid, Spain (RS, EP-C, SS); the Neurology Department, Hospital Ramón y Cajal, Madrid, Spain (JL-S, VM); the Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain (JL-S, VM); the CIBERNED, Instituto de Salud Carlos III, Madrid, Spain (JL-S); the Neurology Department, Complejo Asistencial Universitario Burgos, Burgos (EB), Spain; the Neurology Department, Movement Disorders Unit, Fundació Clinic per la Recerca Biomèdica, Barcelona, Spain (EM, PS, LV); and the Dementia Unit, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain (MN).
mesh_terms: D000328:Adult; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics / Q000523:psychology*; D007406:Interview, Psychological; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D015588:Observer Variation; D000066553:Problem Behavior; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D011594:Psychometrics; D014175:Translating