title: Antiherpetic Plants: A Review of Active Extracts, Isolated Compounds, and Bioassays.
abstract: Herpes simplex is a disease that is widely distributed throughout the world. It is caused by herpes simplex virus type 1 (HSV-1) and simplex virus type 2 (HSV-2). The drugs of choice for treatment are acyclovir (ACV), Penciclovir (PCV) and other guanine analogues, which have the same mechanism of action. However, due to the constant increase of ACV-resistant strains in immunocompromised patients, it is necessary to find new treatment alternatives. It has been shown that natural products are a good alternative for the treatment of these diseases as well as being an excellent source of compounds with anti-herpetic activity, which may be useful for the development of new drugs and act through a mechanism of action different from ACV and PCV. This paper compiles reports on extracts and compounds isolated from plants that have anti-herpetic activity. We present an analysis of the solvents most widely used for extraction from plants as well as cells and commonly used methods for evaluating cytotoxic and anti-herpetic activity. Families that have a higher number of plants with anti-herpetic activity are evaluated, and we also highlight the importance of studies of mechanisms of action of extracts and compounds with anti-herpetic activity.
authors.forename: David
authors.initials: D
authors.lastname: Silva-Mares
authors.forename: Ernesto
authors.initials: E
authors.lastname: Torres-López
authors.forename: Verónica M
authors.initials: VM
authors.lastname: Rivas-Galindo
mesh_terms: D000998:Antiviral Agents / Q000302:isolation & purification* / Q000627:therapeutic use; D006566:Herpesviridae Infections / Q000188:drug therapy*; D006801:Humans; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry* / Q000627:therapeutic use
chemical_list: D000998:Antiviral Agents; D010936:Plant Extracts