title: Connective tissue disease-related interstitial lung disease.
abstract: Interstitial lung disease (ILD) is commonly present in patients with an underlying connective tissue disease (CTD), particularly those with systemic sclerosis, rheumatoid arthritis, and inflammatory myositis. The clinical spectrum can range from asymptomatic findings on imaging to respiratory failure and death. Distinguishing features in the clinical, radiographic, and histopathologic characteristics of CTD-ILD subsets can predict prognosis and treatment response. Treatment often consists of combinations of immunosuppressive medications, but there is a paucity of guidance in the literature to help clinicians determine appropriate screening and management of CTD-ILD. As such, there is a critical need for studies that can elucidate the natural history of the CTD-ILD, as well as clarify optimal therapies for CTD patients with ILD.
authors.affiliation: University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA.
authors.forename: M Kristen
authors.initials: MK
authors.lastname: Demoruelle
authors.affiliation: University of Toronto, Division of Rheumatology, Mount Sinai Hospital, Toronto, Ontario, Canada.
authors.forename: Shikha
authors.initials: S
authors.lastname: Mittoo
authors.affiliation: National Jewish Health, Division of Pulmonary and Critical Care Medicine, Denver, CO, USA. Electronic address: SolomonJ@NJHealth.org.
authors.forename: Joshua J
authors.initials: JJ
authors.lastname: Solomon
mesh_terms: D001172:Arthritis, Rheumatoid / Q000150:complications; D003240:Connective Tissue Diseases / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000188:drug therapy / Q000209:etiology*; D011379:Prognosis
keywords: Clinical management; Connective tissue disease; Interstitial lung disease; Treatment