title: Cellulose membrane as a biomaterial: from hydrolysis to depolymerization with electron beam.
abstract: The cellulose membrane (CM) is a major component of plant cell walls and is both a chemically and mechanically stable synthetic polymer with many applications for use in tissue engineering. However, due to its dissolution difficulty, there are no known physiologically relevant or pharmaceutically clinical applications for this polymer. Thus, research is underway on controlled and adjusted forms of cellulose depolymerization. To advance the study of applying CM for tissue engineering, we have suggested new possibilities for electron beam (E-beam) treatment of CM. Treatment of CM with an E-beam can modify physical, chemical, molecular and biological properties, so it can be studied continuously to improve its usefulness and to enhance value. We review clinical applications of CM, cellulose binding domains, cellulose crosslinking proteins, conventional hydrolysis of cellulose, and depolymerization with radiation and focus our experiences with depolymerization of E-beam irradiated CM in this article.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, 101 Daehak-ro, Jongno-gu, Seoul, 110-768 South Korea.
authors.forename: Mi Young
authors.initials: MY
authors.lastname: Eo
authors.affiliation: Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, 101 Daehak-ro, Jongno-gu, Seoul, 110-768 South Korea.
authors.forename: Huan
authors.initials: H
authors.lastname: Fan
authors.affiliation: Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, 101 Daehak-ro, Jongno-gu, Seoul, 110-768 South Korea.
authors.forename: Yun Ju
authors.initials: YJ
authors.lastname: Cho
authors.affiliation: Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, 101 Daehak-ro, Jongno-gu, Seoul, 110-768 South Korea.
authors.forename: Soung Min
authors.initials: SM
authors.lastname: Kim
authors.affiliation: Department of Oral Pathology, College of Dentistry, Gangneung-Wonju National University, Gangneung, 123 Chibyon-dong, Gangneung, 210-702 South Korea.
authors.forename: Suk Keun
authors.initials: SK
authors.lastname: Lee
keywords: Cellulose binding domain; Cellulose crosslinking protein; Cellulose membrane (CM); Depolymerization; Electron beam (E-beam) irradiation