title: The application of prodrug-based nano-drug delivery strategy in cancer combination therapy.
abstract: Single drug therapy that leads to the multidrug resistance of cancer cells and severe side-effect is a thing of the past. Combination therapies that affect multiple signaling pathways have been the focus of recent active research. Due to the successful development of prodrug-based nano-drug delivery systems (P-N-DDSs), their use has been extended to combination therapy as drug delivery platforms. In this review, we focus specifically on the P-N-DDSs in the field of combination therapy including the combinations of prodrugs with different chemotherapeutic agents, other therapeutic agents, nucleic acid or the combination of different types of therapy (e.g. chemotherapy and phototherapy). The relevant examples of prodrug-based nanoparticulate drug delivery strategy in combination cancer therapy from the recent literature are discussed to demonstrate the feasibilities of relevant technology.
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, Shandong University, 44 Wenhuaxi Road, Jinan, Shandong Province 250012, China.
authors.forename: Yanxiu
authors.initials: Y
authors.lastname: Ge
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, Shandong University, 44 Wenhuaxi Road, Jinan, Shandong Province 250012, China.
authors.forename: Yakun
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, Shandong University, 44 Wenhuaxi Road, Jinan, Shandong Province 250012, China. Electronic address: cnlilingbing@yahoo.com.
authors.forename: Lingbing
authors.initials: L
authors.lastname: Li
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D016503:Drug Delivery Systems; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D009369:Neoplasms / Q000628:therapy*; D011355:Prodrugs / Q000008:administration & dosage*
chemical_list: D000970:Antineoplastic Agents; D011355:Prodrugs
keywords: Combination therapy; Drug delivery; Prodrug; Prodrug-based nano-drug delivery system