title: Epilepsy and tobacco smoking: a cross-sectional study.
abstract: There is little data concerning the prevalence of smoking in the population of people with epilepsy. The present study addresses this aspect in a sample of 429 unselected adults with epilepsy living in French-speaking Switzerland. The criterion of at least one cigarette per day for the past 6 months was used to define the status of "current" smoker. The questionnaires included questions about the type of epilepsy and tobacco consumption and were prospectively filled by attending neurologists in the presence of their patient, ensuring a reliable diagnosis of epilepsy. Data were compared with those of the "Tabakmonitoring" data collection, which gives annually detailed information about tobacco use habits in the Switzerland's population according to the different linguistic regions. Among patients suffering from epilepsy, the prevalence of current smoking was 32.1 % (28.8 % among women and 35 % among men), while the prevalence of smoking was 19.0 % in the general population in French-speaking Switzerland in the same period [OR 2.0, confidence interval (CI) 1.6-2.5, p < 0.001]. The subgroup of patients with epilepsy suffering from idiopathic (genetic) generalized epilepsy had the highest prevalence of smoking: 44.3 versus 27.8 % in the other types of epilepsy-p = 0.03. Epilepsy appears significantly correlated to smoking. The possible causal relationship, such as common genetic susceptibility to epilepsy and to nicotine addiction, indirect comorbidity through stress or depression associated with epilepsy, beneficial effect of nicotine on epilepsy, still remains unclear and deserves further studies.
authors.affiliation: Department of General Internal Medicine, University Hospital and Medical School of Geneva, Geneva, Switzerland.
authors.forename: Omar
authors.initials: O
authors.lastname: Torriani
authors.affiliation: Department of General Internal Medicine, University Hospital and Medical School of Geneva, Geneva, Switzerland.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Vuilleumier
authors.affiliation: Department of Clinical Epidemiology, University Hospital and Medical School of Geneva, Geneva, Switzerland.
authors.forename: Thomas
authors.initials: T
authors.lastname: Perneger
authors.affiliation: Clinique La Prairie, Clarens, Switzerland.
authors.forename: Paul-Andre
authors.initials: PA
authors.lastname: Despland
authors.affiliation: Institution de Lavigny, Lavigny, Switzerland.|Department of Clinical Neurosciences, CHUV and University of Lausanne, Lausanne, Switzerland.
authors.forename: Malin
authors.initials: M
authors.lastname: Maeder
authors.affiliation: Department of Neurology, University Hospitals and Medical School of Geneva, 4 rue Gabrielle-Perret-Gentil, 1211, Geneva 14, Switzerland.
authors.forename: Anne-Chantal
authors.initials: AC
authors.lastname: Héritier-Barras
authors.affiliation: Department of Neurology, University Hospitals and Medical School of Geneva, 4 rue Gabrielle-Perret-Gentil, 1211, Geneva 14, Switzerland.
authors.forename: Serge
authors.initials: S
authors.lastname: Vulliemoz
authors.affiliation: Department of Neurology, University Hospitals and Medical School of Geneva, 4 rue Gabrielle-Perret-Gentil, 1211, Geneva 14, Switzerland.
authors.forename: Margitta
authors.initials: M
authors.lastname: Seeck
authors.affiliation: Department of Clinical Neurosciences, CHUV and University of Lausanne, Lausanne, Switzerland.
authors.forename: Andrea O
authors.initials: AO
authors.lastname: Rossetti
authors.affiliation: Department of Neurology, University Hospitals and Medical School of Geneva, 4 rue Gabrielle-Perret-Gentil, 1211, Geneva 14, Switzerland. Fabienne.Picard@hcuge.ch.
authors.forename: Fabienne
authors.initials: F
authors.lastname: Picard
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D003430:Cross-Sectional Studies; D004827:Epilepsy / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012907:Smoking / Q000453:epidemiology*; D013557:Switzerland / Q000453:epidemiology; D055815:Young Adult
keywords: Epilepsy; French-speaking Switzerland; Nicotine; Prevalence; Smoking; Tobacco