title: Synthesis and quality control of [(18) F]T807 for tau PET imaging.
abstract: The detailed synthesis and quality control of [(18) F]T807, radiotracer for tau protein aggregate imaging, are described. The radiotracer synthesis was accomplished in an average of 48 min with an average specific activity at end-of-synthesis of over 4.4 TBq/µmole (120 Ci/µmole) and an average radiochemical yield of 32%. Compliance with all standard US Pharmacopeia Chapter <823> acceptance tests was observed.
authors.affiliation: Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Holt
authors.affiliation: Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Hayden T
authors.initials: HT
authors.lastname: Ravert
authors.affiliation: Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Robert F
authors.initials: RF
authors.lastname: Dannals
mesh_terms: D002243:Carbolines / Q000138:chemical synthesis* / Q000737:chemistry; D060326:Chemistry Techniques, Synthetic; D049268:Positron-Emission Tomography / Q000379:methods*; D011786:Quality Control; D011854:Radiochemistry; D016875:tau Proteins / Q000378:metabolism*
chemical_list: D002243:Carbolines; D016875:tau Proteins; C000591008:7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole
keywords: PET; fluorine-18; microwave; quality control; tau