title: The acute effect of pseudoephedrine on choroidal thickness.
abstract: OBJECTIVE
  To investigate the acute effects of pseudoephedrine (PE) on choroidal thickness in healthy young patients.
  
  
  METHODS
  Fifty patients with nasal and sinus congestion who were prescribed 60 mg oral PE at the otolaryngology department were recruited for this study. The enhanced depth imaging (EDI) optic coherence tomography (OCT) (Spectralis OCT; Heidelberg Engineering, Heidelberg, Germany) choroidal thickness measurements were performed at baseline and 1, 3 and 6 hours at 7 points.
  
  
  RESULTS
  The right eyes of 50 healthy subjects (22 women and 28 men) were included in this study. The mean choroidal thickness at fovea was 293.12 μm, 279.80 μm, 295.80 μm, and 294.52 μm at baseline, 1, 3 and 6 hours respectively. A significant reduction in choroidal thickness versus baseline was observed at all points at 1 hour.
  
  
  CONCLUSIONS
  The choroidal thickness decreased 1 hour after oral administration of PE and returned to baseline thickness at 3 hours. We suppose that this transient decrease might be associated with vasoconstriction due to activation of sympathetic alpha adrenoceptors.
authors.affiliation: Medical Sciences University Training and Research Hospital, Department of Otorhinolaryngolgy, Konya,Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Ovet
authors.affiliation: Medical Sciences University Training and Research Hospital, Department of Ophthalmology, Konya,Turkey.
authors.forename: I
authors.initials: I
authors.lastname: Alpfidan
authors.affiliation: Medical Sciences University Training and Research Hospital, Department of Ophthalmology, Konya,Turkey.
authors.forename: Y
authors.initials: Y
authors.lastname: Sakarya
authors.affiliation: Medical Sciences University Training and Research Hospital, Department of Ophthalmology, Konya,Turkey.
authors.forename: R
authors.initials: R
authors.lastname: Sakarya
authors.affiliation: Medical Sciences University Training and Research Hospital, Department of Ophthalmology, Konya,Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Ozcimen
authors.affiliation: Medical Sciences University Training and Research Hospital, Department of Ophthalmology, Konya,Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Göktaş
authors.affiliation: Medical Sciences University Training and Research Hospital, Department of Ophthalmology, Konya,Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Erdoğan
mesh_terms: D000293:Adolescent; D000328:Adult; D002829:Choroid / Q000187:drug effects*; D005260:Female; D005858:Germany; D006801:Humans; D008297:Male; D011446:Prospective Studies; D054199:Pseudoephedrine / Q000494:pharmacology*; D041623:Tomography, Optical Coherence; D055815:Young Adult
chemical_list: D054199:Pseudoephedrine
keywords: Choroid; EDI- OCT; Pseudoephedrine; Retina; Sympathomimetic