title: Plasma concentrations of buprenorphine following a single subcutaneous administration of a sustained release formulation of buprenorphine in sheep.
abstract: The goal of the present study was to evaluate the potential use of slow release buprenorphine in sheep. Twelve adult female sheep (6 Dorset and 6 Suffolk, 12 months of age) were used for this project and were divided into 2 experimental groups (n = 6/group comprising 3 Dorset and 3 Suffolk sheep). Sustained release (SR) buprenorphine was administered subcutaneously in the scapular region at a concentration of 0.1 mg/kg body weight (BW) for group 1 and of 0.05 mg/kg BW for group 2. Following blood collections at selected time points, plasma concentrations of buprenorphine was performed by tandem liquid chromatograph-mass spectrometry. Mean buprenorphine concentration was above 0.1 ng/mL at 48 h up to 192 h post-injection for group 1 and it was above 0.1 ng/mL at 48 h up to 72 h post-injection for group 2. In conclusion, a long lasting potential analgesic plasma level of buprenorphine is attained following a single subcutaneous injection of 0.1 mg/kg BW of SR buprenorphine in sheep. However the effective analgesic plasma threshold still needs to be determined in sheep.
authors.affiliation: Département de Biomédecine Vétérinaire, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Quebec J2S 2M2 (Zullian, Dodelet-Devillers, Beaudry, Vachon); AccelLab Preclinical Research, Boisbriand, Quebec J7H 1N8 (Lema, Lavoie).
authors.forename: Chiara
authors.initials: C
authors.lastname: Zullian
authors.affiliation: Département de Biomédecine Vétérinaire, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Quebec J2S 2M2 (Zullian, Dodelet-Devillers, Beaudry, Vachon); AccelLab Preclinical Research, Boisbriand, Quebec J7H 1N8 (Lema, Lavoie).
authors.forename: Pablo
authors.initials: P
authors.lastname: Lema
authors.affiliation: Département de Biomédecine Vétérinaire, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Quebec J2S 2M2 (Zullian, Dodelet-Devillers, Beaudry, Vachon); AccelLab Preclinical Research, Boisbriand, Quebec J7H 1N8 (Lema, Lavoie).
authors.forename: Melissa
authors.initials: M
authors.lastname: Lavoie
authors.affiliation: Département de Biomédecine Vétérinaire, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Quebec J2S 2M2 (Zullian, Dodelet-Devillers, Beaudry, Vachon); AccelLab Preclinical Research, Boisbriand, Quebec J7H 1N8 (Lema, Lavoie).
authors.forename: Aurore
authors.initials: A
authors.lastname: Dodelet-Devillers
authors.affiliation: Département de Biomédecine Vétérinaire, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Quebec J2S 2M2 (Zullian, Dodelet-Devillers, Beaudry, Vachon); AccelLab Preclinical Research, Boisbriand, Quebec J7H 1N8 (Lema, Lavoie).
authors.forename: Francis
authors.initials: F
authors.lastname: Beaudry
authors.affiliation: Département de Biomédecine Vétérinaire, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Quebec J2S 2M2 (Zullian, Dodelet-Devillers, Beaudry, Vachon); AccelLab Preclinical Research, Boisbriand, Quebec J7H 1N8 (Lema, Lavoie).
authors.forename: Pascal
authors.initials: P
authors.lastname: Vachon
mesh_terms: D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics; D000818:Animals; D002047:Buprenorphine / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations; D005260:Female; D006207:Half-Life; D007279:Injections, Subcutaneous; D012756:Sheep / Q000097:blood*
chemical_list: D000701:Analgesics, Opioid; D003692:Delayed-Action Preparations; D002047:Buprenorphine