title: Characterization and Analysis of 2-(2-Phenylethyl)-chromone Derivatives from Agarwood (Aquilaria crassna) by Artificial Holing for Different Times.
abstract: A total of fifty-six chromones, including seven 5,6,7,8-tetrahydro-2-(2-phenylethyl)-chromones (THPECs), five 5,6-epoxy-2-(2-phenylethyl)chromones (EPECs), seven 5,6:7,8-diepoxy-2-(2-phenylethyl)chromones (DEPECs) and thirty-seven 2-(2-phenylethyl)chromones of the flidersia type (FTPECs), were characterized by HPLC/DAD/ESI/MS/MS in three agarwood samples (from Aquilaria crassna) induced by artificial holing with different holing times. The characteristic fragmentation behavior of DEPECs and EPECs, and the methods to distinguish these four types of chromones by MS analysis were described for the first time. In addition, it was found that the relative contents of DEPECs and EPECs were down-regulated, while the relative contents of THPECs and FTPECs were up-regulated for the samples from two, four and five years of the agarwood formation time. However, the relative contents of six most widespread and abundant FTPECs presented roughly upward based on the formation time. These results could be referenced to distinguish different agarwood samples collected from different formation time.
authors.affiliation: Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, Hainan, China. jinlyang@126.com.
authors.forename: Jinling
authors.initials: J
authors.lastname: Yang
authors.affiliation: Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, Hainan, China. dongwenhua@itbb.org.cn.
authors.forename: Wenhua
authors.initials: W
authors.lastname: Dong
authors.affiliation: Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, Hainan, China. kongfandong@itbb.org.cn.
authors.forename: Fandong
authors.initials: F
authors.lastname: Kong
authors.affiliation: Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, Hainan, China. liaoge828@aliyun.com.
authors.forename: Ge
authors.initials: G
authors.lastname: Liao
authors.affiliation: Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, Hainan, China. wangjun@itbb.org.cn.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, Hainan, China. liwei@itbb.org.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, Hainan, China. meiwenli@itbb.org.cn.
authors.forename: Wenli
authors.initials: W
authors.lastname: Mei
authors.affiliation: Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, Hainan, China. daihaofu@itbb.org.cn.
authors.forename: Haofu
authors.initials: H
authors.lastname: Dai
mesh_terms: D002851:Chromatography, High Pressure Liquid; D002867:Chromones / Q000737:chemistry*; D005285:Fermentation; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D053719:Tandem Mass Spectrometry; D029645:Thymelaeaceae / Q000737:chemistry*; D014934:Wood / Q000737:chemistry*
chemical_list: D002867:Chromones; D010936:Plant Extracts
keywords: 2-(2-phenylethyl) chromone derivatives; Aquilaria crassna; HPLC/DAD/ESI/MS/MS; artificial holing agarwood