title: Plasmonic nanohalo optical probes for highly sensitive imaging of survivin mRNA in living cells.
abstract: A strategy is designed for sensitive detection of tumor biomarker survivin mRNA based on resonance Rayleigh scattering of a single AuNP nanohalo probe that couples large gold nanoparticles (L-AuNPs, 52 nm) with small AuNPs (S-AuNPs, 18 nm) through the affinity interaction between streptavidin and biotin. This core-satellite plasmon ruler is further applied to imaging survivin mRNA in living cells.
authors.affiliation: State Key Laboratory of Analytical Chemistry for Life Science and Collaborative Innovation Center of Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China. weizhao@nju.edu.cn xujj@nju.edu.cn.
authors.forename: Guang-Sheng
authors.initials: GS
authors.lastname: Qian
authors.forename: Bin
authors.initials: B
authors.lastname: Kang
authors.forename: Zhuo-Lei
authors.initials: ZL
authors.lastname: Zhang
authors.forename: Xiang-Ling
authors.initials: XL
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
authors.forename: Jing-Juan
authors.initials: JJ
authors.lastname: Xu
authors.forename: Hong-Yuan
authors.initials: HY
authors.lastname: Chen
mesh_terms: D001710:Biotin / Q000737:chemistry / Q000378:metabolism; D006046:Gold / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000235:genetics*; D053768:Metal Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D012333:RNA, Messenger / Q000737:chemistry / Q000378:metabolism*; D019809:Streptavidin / Q000737:chemistry / Q000378:metabolism; D020349:Surface Plasmon Resonance; D000077022:Survivin
chemical_list: C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D012333:RNA, Messenger; D000077022:Survivin; D001710:Biotin; D006046:Gold; D019809:Streptavidin