title: Why is it so difficult to show that prothrombin complex concentrates are superior to fresh-frozen plasma for warfarin reversal?
authors.affiliation: Sheffield Haemophilia and Thrombosis Centre, Royal Hallamshire Hospital, Sheffield, United Kingdom.
authors.forename: Giorgia
authors.initials: G
authors.lastname: Saccullo
authors.affiliation: Sheffield Haemophilia and Thrombosis Centre, Royal Hallamshire Hospital, Sheffield, United Kingdom.
authors.forename: Alexandra M
authors.initials: AM
authors.lastname: Bucko
authors.affiliation: Sheffield Haemophilia and Thrombosis Centre, Royal Hallamshire Hospital, Sheffield, United Kingdom.
authors.forename: Joost J
authors.initials: JJ
authors.lastname: Van Veen
authors.affiliation: Sheffield Haemophilia and Thrombosis Centre, Royal Hallamshire Hospital, Sheffield, United Kingdom.
authors.forename: Michael
authors.initials: M
authors.lastname: Makris
mesh_terms: D001779:Blood Coagulation Factors / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D010949:Plasma; D020011:Protective Agents / Q000627:therapeutic use*; D014859:Warfarin / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D001779:Blood Coagulation Factors; D020011:Protective Agents; C025667:prothrombin complex concentrates; D014859:Warfarin