title: Current-day precision oncology: from cancer prevention, screening, drug development, and treatment - have we fallen short of the promise?
abstract: Precision oncology has been a strategy of prevention, screening, and treatment. Although much has been invested, have the results fallen so far short of the promise? The advancement of technology and research has opened new doors, yet a variety of pitfalls are present. This review presents the successes, failures, and opportunities of precision oncology in the current landscape.
  
  
  
  The use of targeted gene sequencing and the overwhelming results of superresponders have generated much excitement and support for precision oncology from the medical community. Despite notable successes, many challenges still pave the way of precision oncology: intratumoral heterogeneity, the need for serial biopsies, availability of treatments, target prioritization, ethical issues with germline incidental findings, medical education, clinical trial design, and costs.
  
  
  
  Precision oncology shows much potential through the use of next-generation sequencing and molecular advances, but does this potential warrant the investment? There are many obstacles on the way of this technology that should make us question if the investment (both monetary and man-hours) will live up to the promise. The review aims to not criticize this technology, but to give a realistic view of where we are, especially regarding cancer treatment and prevention.
authors.affiliation: aDepartment of Cancer Prevention, University of Texas MD Anderson Cancer Center Houston, Texas, USA bDepartment of Medicine, Medical Oncology Clinic, Institut Jules Bordet and University Libre de Bruxelles, Brussels, Belgium.
authors.forename: Gilberto
authors.initials: G
authors.lastname: Morgan
authors.forename: Philippe
authors.initials: P
authors.lastname: Aftimos
authors.forename: Ahmad
authors.initials: A
authors.lastname: Awada
mesh_terms: D015195:Drug Design; D055088:Early Detection of Cancer / Q000379:methods; D006801:Humans; D008495:Medical Oncology / Q000379:methods* / Q000639:trends; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000517:prevention & control / Q000628:therapy*; D057285:Precision Medicine / Q000379:methods* / Q000639:trends