title: Sonomicrometry-Based Analysis of Post-Myocardial Infarction Regional Mechanics.
abstract: Following myocardial infarction (MI), detrimental changes to the geometry, composition, and mechanical properties of the left ventricle (LV) are initiated in a process generally termed adverse post-MI remodeling. Cumulatively, these changes lead to a loss of LV function and are deterministic factors in the progression to heart failure. Proposed therapeutic strategies to target aberrant LV mechanics post-MI have shown potential to stabilize LV functional indices throughout the remodeling process. The in vivo quantification of LV mechanics, particularly within the MI region, is therefore essential to the continued development and evaluation of strategies to interrupt the post-MI remodeling process. The present study utilizes a porcine MI model and in vivo sonomicrometry to characterize MI region stiffness at 14 days post-MI. Obtained results demonstrate a significant dependence of mechanical properties on location and direction within the MI region, as well as cardiac phase. While approaches for comprehensive characterization of LV mechanics post-MI still need to be improved and standardized, our findings provide insight into the issues and complexities that must be considered within the MI region itself.
authors.affiliation: University of South Carolina College of Engineering and Computing, Columbia, USA.|Cardiovascular Translational Research Center, University of South Carolina School of Medicine, Columbia, USA.
authors.forename: Eva
authors.initials: E
authors.lastname: Romito
authors.affiliation: Cardiovascular Translational Research Center, University of South Carolina School of Medicine, Columbia, USA.|Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, USA.
authors.forename: Heather
authors.initials: H
authors.lastname: Doviak
authors.affiliation: Cardiovascular Translational Research Center, University of South Carolina School of Medicine, Columbia, USA.|Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, USA.
authors.forename: Christina
authors.initials: C
authors.lastname: Logdon
authors.affiliation: Cardiovascular Translational Research Center, University of South Carolina School of Medicine, Columbia, USA.
authors.forename: Parker
authors.initials: P
authors.lastname: Freels
authors.affiliation: University of South Carolina College of Engineering and Computing, Columbia, USA. shazly@usc.sc.edu.
authors.forename: Tarek
authors.initials: T
authors.lastname: Shazly
authors.affiliation: University of South Carolina College of Engineering and Computing, Columbia, USA.|Cardiovascular Translational Research Center, University of South Carolina School of Medicine, Columbia, USA.|Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, USA.|WJB Dorn Veteran Affairs Medical Center, Columbia, SC, USA.
authors.forename: Francis G
authors.initials: FG
authors.lastname: Spinale
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004452:Echocardiography; D008955:Models, Cardiovascular; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000503:physiopathology; D013552:Swine; D016277:Ventricular Function, Left; D020257:Ventricular Remodeling
keywords: Anisotropy; Heterogeneity; Myocardial infarction; Myocardial stiffness