title: Genetic expressions of thrombophilic factors in patients with Sheehan's syndrome.
abstract: OBJECTIVE
  The aim of this study was to evaluate the roles of factors associated with coagulation in the etiology and pathogenesis of Sheehan's syndrome (SS) which is a frequent cause of hypopituitarism in underdeveloped and developing regions of the world.
  
  
  METHODS
  Mean prothrombin time (PT), activated partial thromboplastin time (APTT) and expression levels of genes, which included methylenetetrahydrofolate reductase (MTHFR), angiotensin I converting enzyme (ACE), coagulation factor V (FV), FVII, FVIII and FIX in 44 patients with SS were compared with 43 healthy subjects.
  
  
  RESULTS
  The mean expression level of the ACE gene was significantly lower, while that of the FV gene was significantly higher in the patients with SS. No significant difference was found between the patients with SS and the healthy subjects in the comparisons of the remaining gene expression values, as well as in the PT and APTT values.
  
  
  CONCLUSIONS
  An increased expression of the FV gene may be a contributing factor for the development of SS in some patients. Further studies are required to clarify the roles of coagulation disorders in the development of SS.
authors.affiliation: a Department of Endocrinology.
authors.forename: Fahri
authors.initials: F
authors.lastname: Bayram
authors.affiliation: a Department of Endocrinology.
authors.forename: Halit
authors.initials: H
authors.lastname: Diri
authors.affiliation: b Department of Medical Biology , and.
authors.forename: Elif Funda
authors.initials: EF
authors.lastname: Sener
authors.affiliation: c Department of Medical Genetics , Erciyes University Medical School , Kayseri , Turkey.
authors.forename: Munis
authors.initials: M
authors.lastname: Dundar
authors.affiliation: a Department of Endocrinology.
authors.forename: Yasin
authors.initials: Y
authors.lastname: Simsek
mesh_terms: D000368:Aged; D005260:Female; D015870:Gene Expression; D006801:Humans; D007018:Hypopituitarism / Q000097:blood* / Q000235:genetics; D008875:Middle Aged; D019851:Thrombophilia / Q000097:blood* / Q000235:genetics
keywords: Etiopathogenesis; Sheehan’s syndrome; genetic; thrombophilia