title: Randomized controlled study of endoscopic band ligation and argon plasma coagulation in the treatment of gastric antral and fundal vascular ectasia.
abstract: BACKGROUND
  Gastric antral vascular ectasia (GAVE) is characterized by mucosal and submucosal vascular ectasia causing recurrent hemorrhage and thus, chronic anemia, in patients with cirrhosis. Treatment with argon plasma coagulation (APC) is an effective and safe method, but requires multiple sessions of endoscopic therapy. Endoscopic band ligation (EBL) was found to be a good alternative for APC as a treatment for GAVE, especially in refractory cases. The aim of this prospective randomized controlled study was to evaluate the safety and efficacy of EBL, as compared to APC, in the treatment of GAVE and gastric fundal vascular ectasia (GFVE).
  
  
  METHODS
  A total of 88 cirrhotic patients with GAVE were prospectively randomized to endoscopic treatment with either EBL or APC, every 2 weeks until complete obliteration was accomplished; then they were followed up endoscopically after 6 months, plus they had monthly measurement of hemoglobin levels during that period.
  
  
  RESULTS
  We describe the presence of mucosal and submucosal lesions in the gastric fundal area that were similar to those found in GAVE in 13 patients (29.5%) of the EBL group and 9 patients (20.5%) of the APC group; we named this GFVE. In these cases, we treated the fundal lesions with the same techniques we had used for treating GAVE, according to the randomization. We found that EBL significantly decreased the number of sessions required for complete obliteration of the lesions (2.98 sessions compared to 3.48 sessions in the APC group (p < 0.05)). Hemoglobin levels increased significantly after obliteration of the lesions in both groups, compared to pretreatment values (p < 0.05), but with no significant difference between the two groups (p > 0.05); however, the EBL group of patients required a significantly smaller number of units of blood transfusion than the APC group of patients (p < 0.05). There were no significant differences in adverse events nor complications between the two groups (p > 0.05).
  
  
  CONCLUSIONS
  This study described and histologically proved the presence of GFVE occurring comcomitantly with GAVE in cirrhotic patients. We showed that GFVE can be successfully managed by EBL or APC. Our study revealed that EBL is more effective and is comparable in safety to APC, in the treatment of GAVE and GFVE in cirrhotic patients.
authors.affiliation: Department of Tropical Medicine, Tanta University Hospital, Egypt.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Elhendawy
authors.affiliation: Department of Tropical Medicine, Tanta University Hospital, Egypt.
authors.forename: Samah
authors.initials: S
authors.lastname: Mosaad
authors.affiliation: Department of Tropical Medicine, Tanta University Hospital, Egypt.
authors.forename: Walaa
authors.initials: W
authors.lastname: Alkhalawany
authors.affiliation: Department of Tropical Medicine, Tanta University Hospital, Egypt.
authors.forename: Lobna
authors.initials: L
authors.lastname: Abo-Ali
authors.affiliation: Department of Internal Medicine, Tanta University Hospital, Egypt.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Enaba
authors.affiliation: Department of Pathology, Tanta University Hospital, Egypt.
authors.forename: Aymen
authors.initials: A
authors.lastname: Elsaka
authors.affiliation: Department of Tropical Medicine, Tanta University Hospital, Egypt.
authors.forename: Asem A
authors.initials: AA
authors.lastname: Elfert
keywords: Anemia; argon plasma coagulation; cirrhosis; comparative study; endoscopic band ligation; gastric antral vascular ectasia; gastric fundal vascular ectasia; transfusion; treatment techniques