title: [A Systematic Review of Phytotherapy for Acute Rhinosinusitis].
abstract: Herbal medicine is a promising alternative in the treatment of acute rhinosinusitis (ARS). We performed a systematic review for phytopharmaceutical treatments of ARS. A computerized search of databases (Cochrane Library, PubMed, and Scopus) up to 16 September 2015 was performed. Randomized controlled trials (RCTs) and controlled trials (CTs) were included and assessed using the Cochrane risk of bias tool. Seven trials on Pelargonium sidoides (EPs 7630, Umckaloabo®), Myrtol (GeloMyrtol® forte), BNO 1016 (Sinupret® extract), BNO 101 (Sinupret®), Cyclamen europaeum (Nasodren®), and Esberitox® were included. Risk of bias was heterogeneous. EPs 7630 appeared to be useful in the treatment of ARS. Myrtol showed benefits against a placebo compound, and BNO 1016 and BNO 101 might be helpful; however, there was little evidence for the effectiveness of Cyclamen europaeum and Esberitox®. Herbal medicine might be effective for the treatment of ARS, but given the low number of clinical trials and the heterogeneous methodological quality, further research is necessary.
authors.affiliation: Centre of Integrative Gastroenterology, Department of Internal and Integrative Medicine, Kliniken Essen-Mitte, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany.
authors.forename: Anna K
authors.initials: AK
authors.lastname: Koch
authors.forename: Petra
authors.initials: P
authors.lastname: Klose
authors.forename: Romy
authors.initials: R
authors.lastname: Lauche
authors.forename: Holger
authors.initials: H
authors.lastname: Cramer
authors.forename: Jennifer
authors.initials: J
authors.lastname: Baasch
authors.forename: Gustav J
authors.initials: GJ
authors.lastname: Dobos
authors.forename: Jost
authors.initials: J
authors.lastname: Langhorst
mesh_terms: D000208:Acute Disease; D018849:Controlled Clinical Trials as Topic; D006801:Humans; D008517:Phytotherapy / Q000009:adverse effects*; D010936:Plant Extracts / Q000009:adverse effects* / Q000627:therapeutic use*; D010946:Plants, Medicinal / Q000009:adverse effects*; D016032:Randomized Controlled Trials as Topic; D012220:Rhinitis / Q000188:drug therapy*; D012852:Sinusitis / Q000188:drug therapy*
chemical_list: D010936:Plant Extracts