title: Development of (111)In-labeled porphyrins for SPECT imaging.
abstract: OBJECTIVE
  The aim of this research was the development of (111)In-labeled porphyrins as possible radiopharmaceuticals for the imaging of tumors.
  
  
  METHODS
  Ligands, 5, 10, 15, 20-tetrakis (3, 5-dihydroxyphenyl) porphyrin) (TDHPP), 5, 10, 15, 20-tetrakis (4-hydroxyphenyl) porphyrin (THPP) and 5, 10, 15, 20-tetrakis (3,4-dimethoxyphenyl) porphyrin) (TDMPP) were labeled with (111)InCl3 (produced from proton bombardment of natCd target) in 60 min at 80 ºC. Quality control of labeled compounds was performed via RTLC and HPLC followed by stability studies in final formulation and presence of human serum at 37 ºC for 48 h as well as partition coefficient determination. The biodistribution studies performed using tissue dissection and SPECT imaging up to 24h.
  
  
  RESULTS
  The complexes were prepared with more than 99% radiochemical purity (HPLC and RTLC) and high stability to 48 h. Partition coefficients (calculated as log P) for (111)In-TDHPP, (111)In-THPP and (111)In-TDMPP were 0.88, 0.8 and 1.63 respectively.
  
  
  CONCLUSIONS
  Due to urinary excretion with fast clearance for (111)In-TDMPP, this complex is probably a suitable candidate for considering as a possible tumor imaging agent.
authors.affiliation: Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), Iran.
authors.forename: Shaghayegh
authors.initials: S
authors.lastname: Sadeghi
authors.affiliation: Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Mirzaei
authors.affiliation: Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Rahimi
authors.affiliation: Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), Iran.
authors.forename: Amir R
authors.initials: AR
authors.lastname: Jalilian
keywords: 111In; Biodistribution; Hydroxy phenyl porphyrins; Radiolabeling; SPECT