title: Validity of Self-Reported Medication Use Compared With Pharmacy Records in a Cohort of Older Women: Findings From the Women's Health Initiative.
abstract: Inaccurate self-reported data on medication exposure lead to less reliable study findings. From 2013 to 2015, we assessed the validity of information on medication use collected via a mailed medication inventory among 223 Women's Health Initiative participants who were members of a health-care delivery system. Self-reported information on medication use was compared with pharmacy records for statins, calcium channel blockers, β-blockers, and bisphosphonates. We assessed sensitivity, specificity, and positive predictive value (PPV) for current medication use. We assessed agreement on duration of use (<2, 2, 3, 4, or ≥5 years) by means of the weighted κ statistic. The mean age of participants was 77 years. Statins, β-blockers, and calcium channel blockers were each reported by over 15% of women, and bisphosphonates were reported by 4.5%. Compared with pharmacy records, the sensitivity, specificity, and PPV for self-reported use of statins, β-blockers, and calcium channel blockers were all 95% or greater. The sensitivity and PPV for bisphosphonate use were both 80% (95% confidence interval: 44, 97), and specificity was 99% (95% confidence interval: 97, 100). The κ statistic for duration of use was 0.87 or greater for all 4 medication classes. Compared with pharmacy records, self-reported information on current medication use and duration of use collected via mailed medication inventory among older women had almost perfect agreement for use of statins, β-blockers, and calcium channel blockers.
authors.forename: Rebecca L
authors.initials: RL
authors.lastname: Drieling
authors.forename: Andrea Z
authors.initials: AZ
authors.lastname: LaCroix
authors.forename: Shirley A A
authors.initials: SA
authors.lastname: Beresford
authors.forename: Denise M
authors.initials: DM
authors.lastname: Boudreau
authors.forename: Charles
authors.initials: C
authors.lastname: Kooperberg
authors.forename: Susan R
authors.initials: SR
authors.lastname: Heckbert
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage* / Q000627:therapeutic use; D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000627:therapeutic use; D050071:Bone Density Conservation Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002121:Calcium Channel Blockers / Q000008:administration & dosage* / Q000627:therapeutic use; D003625:Data Collection / Q000379:methods; D004164:Diphosphonates / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006306:Health Surveys; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage* / Q000627:therapeutic use; D008875:Middle Aged; D010349:Patient Compliance / Q000706:statistics & numerical data*; D010593:Pharmaceutical Services / Q000706:statistics & numerical data*; D055553:Prescription Drugs / Q000008:administration & dosage / Q000627:therapeutic use; D015203:Reproducibility of Results; D057566:Self Report; D016387:Women's Health / Q000706:statistics & numerical data
chemical_list: D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D050071:Bone Density Conservation Agents; D002121:Calcium Channel Blockers; D004164:Diphosphonates; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D055553:Prescription Drugs
keywords: data collection; medications; pharmacy records; questionnaires; self-reporting; validity