title: Gelatinous Transformation of Bone Marrow: A Prospective Tertiary Center Study, Indicating Varying Trends in Epidemiology and Pathogenesis.
abstract: Gelatinous bone marrow transformation (GTBM) also known as serous atrophy is a degenerative change in the hematopoietic bone marrow and is a rare well recognized pathological entity. It was earlier described mainly in association with anorexia nervosa and psychiatric eating disorders, but recently it has been reported in ulcerative colitis, tuberculosis, chronic renal diseases, immuno suppressed states (mainly HIV infection), malignancies and Kala azar. Treatment is based on treating the underlying disease. Our objective was to study the epidemiology and pathogenesis of diseases causing gelatinous transformation of bone marrow, at a tertiary center level. A prospective study was conducted on 732 samples of bone marrow aspirate with the aim of identifying gelatinous transformation in bone marrow aspirates which was confirmed by Alcian blue stain at pH 2.5. The presence of this material was correlated with the hematological profile of the patient, the presenting signs and symptoms and provisional clinical diagnosis at initial visit. Incidence of gelatinous transformation was calculated to be nearly 4.8 % and the condition was more common in males (23) as compared to females (12) (Male:Female = 2:1). Forty percent of the cases were seen in children followed by 37 % in adolescents and young adults. The older individuals comprised only 23 % of the cases. The bone marrow was hypocellular in 21 (60 %), normocellular in 10 (28.5 %) and hypercellular in four cases (11.5 %). Five cases with GTBM progressed to aplastic anaemia of which three were in children.
authors.affiliation: General Hospital, Rohtak, India.
authors.forename: Sneh
authors.initials: S
authors.lastname: Singh
authors.affiliation: Department of Pathology, Pt B.D. Sharma PGIMS, H No. 901 Ward No. 22, Jhang Colony, Rohtak, Haryana India.
authors.forename: Monica
authors.initials: M
authors.lastname: Gupta
authors.affiliation: Department of Pathology, Pt B.D. Sharma PGIMS, H No. 901 Ward No. 22, Jhang Colony, Rohtak, Haryana India.
authors.forename: Gajender
authors.initials: G
authors.lastname: Singh
authors.affiliation: Department of Pathology, Pt B.D. Sharma PGIMS, H No. 901 Ward No. 22, Jhang Colony, Rohtak, Haryana India.
authors.forename: Ashima
authors.initials: A
authors.lastname: Batra
authors.affiliation: GMC, Kolkata, India.
authors.forename: Pratibha
authors.initials: P
authors.lastname: Dhiman
authors.affiliation: Government College for Women, Khanpur kalan, Sonepat, India.
authors.lastname: Abhinav
authors.affiliation: Department of Pathology, Pt B.D. Sharma PGIMS, H No. 901 Ward No. 22, Jhang Colony, Rohtak, Haryana India.
authors.forename: Sonia
authors.initials: S
authors.lastname: Chhabra
authors.affiliation: Department of Pathology, Pt B.D. Sharma PGIMS, H No. 901 Ward No. 22, Jhang Colony, Rohtak, Haryana India.
authors.forename: Rajeev
authors.initials: R
authors.lastname: Sen
keywords: Alcian blue; Bone marrow; Gelatinous transformation; Pathogenesis