title: IL-1 family cytokines in cancer immunity - a matter of life and death.
abstract: IL-1 cytokines constitute a family of biologically active proteins with pleiotropic function especially in immunity. Both protective as well as deleterious properties of individual IL-1 family cytokines in tumor biology have been described. The function of IL-1-family cytokines depends on the producing source, the present (inflammatory) microenvironment and N-terminal proteolytical processing. Each of these determinants is shaped by different modes of cell death. Here we summarize the properties of IL-1 family cytokines in tumor biology, and how they are modulated by cell death.
authors.forename: Javier
authors.initials: J
authors.lastname: Mora
authors.forename: Andreas
authors.initials: A
authors.lastname: Weigert
mesh_terms: D000818:Animals; D016923:Cell Death; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis / Q000378:metabolism*; D009369:Neoplasms / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology
chemical_list: D007375:Interleukin-1