title: Free-breathing Sparse Sampling Cine MR Imaging with Iterative Reconstruction for the Assessment of Left Ventricular Function and Mass at 3.0 T.
abstract: Purpose To prospectively evaluate the accuracy of left ventricle (LV) analysis with a two-dimensional real-time cine true fast imaging with steady-state precession (trueFISP) magnetic resonance (MR) imaging sequence featuring sparse data sampling with iterative reconstruction (SSIR) performed with and without breath-hold (BH) commands at 3.0 T. Materials and Methods Ten control subjects (mean age, 35 years; range, 25-56 years) and 60 patients scheduled to undergo a routine cardiac examination that included LV analysis (mean age, 58 years; range, 20-86 years) underwent a fully sampled segmented multiple BH cine sequence (standard of reference) and a prototype undersampled SSIR sequence performed during a single BH and during free breathing (non-BH imaging). Quantitative analysis of LV function and mass was performed. Linear regression, Bland-Altman analysis, and paired t testing were performed. Results Similar to the results in control subjects, analysis of the 60 patients showed excellent correlation with the standard of reference for single-BH SSIR (r = 0.93-0.99) and non-BH SSIR (r = 0.92-0.98) for LV ejection fraction (EF), volume, and mass (P < .0001 for all). Irrespective of breath holding, LV end-diastolic mass was overestimated with SSIR (standard of reference: 163.9 g ± 58.9, single-BH SSIR: 178.5 g ± 62.0 [P < .0001], non-BH SSIR: 175.3 g ± 63.7 [P < .0001]); the other parameters were not significantly different (EF: 49.3% ± 11.9 with standard of reference, 48.8% ± 11.8 with single-BH SSIR, 48.8% ± 11 with non-BH SSIR; P = .03 and P = .12, respectively). Bland-Altman analysis showed similar measurement errors for single-BH SSIR and non-BH SSIR when compared with standard of reference measurements for EF, volume, and mass. Conclusion Assessment of LV function with SSIR at 3.0 T is noninferior to the standard of reference irrespective of BH commands. LV mass, however, is overestimated with SSIR.©RSNA, 2016 Online supplemental material is available for this article.
authors.affiliation: From the Institute of Clinical Radiology and Nuclear Medicine (S.S., T.H., H.H., S.O.S.) and 1st Department of Medicine (C.D., M.B., T.P.), University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany; MR Product Innovation and Definition, Siemens Healthcare, Erlangen, Germany (M.O.Z., M.S.); Imaging and Computer Vision, Siemens AG, Corporate Technology, Princeton, NJ (M.S.N.); and DZHK (German Centre for Cardiovascular Research) partner site, Mannheim, Germany (C.D., M.B., S.O.S., T.P.).
authors.forename: Sonja
authors.initials: S
authors.lastname: Sudarski
authors.affiliation: From the Institute of Clinical Radiology and Nuclear Medicine (S.S., T.H., H.H., S.O.S.) and 1st Department of Medicine (C.D., M.B., T.P.), University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany; MR Product Innovation and Definition, Siemens Healthcare, Erlangen, Germany (M.O.Z., M.S.); Imaging and Computer Vision, Siemens AG, Corporate Technology, Princeton, NJ (M.S.N.); and DZHK (German Centre for Cardiovascular Research) partner site, Mannheim, Germany (C.D., M.B., S.O.S., T.P.).
authors.forename: Thomas
authors.initials: T
authors.lastname: Henzler
authors.affiliation: From the Institute of Clinical Radiology and Nuclear Medicine (S.S., T.H., H.H., S.O.S.) and 1st Department of Medicine (C.D., M.B., T.P.), University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany; MR Product Innovation and Definition, Siemens Healthcare, Erlangen, Germany (M.O.Z., M.S.); Imaging and Computer Vision, Siemens AG, Corporate Technology, Princeton, NJ (M.S.N.); and DZHK (German Centre for Cardiovascular Research) partner site, Mannheim, Germany (C.D., M.B., S.O.S., T.P.).
authors.forename: Holger
authors.initials: H
authors.lastname: Haubenreisser
authors.affiliation: From the Institute of Clinical Radiology and Nuclear Medicine (S.S., T.H., H.H., S.O.S.) and 1st Department of Medicine (C.D., M.B., T.P.), University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany; MR Product Innovation and Definition, Siemens Healthcare, Erlangen, Germany (M.O.Z., M.S.); Imaging and Computer Vision, Siemens AG, Corporate Technology, Princeton, NJ (M.S.N.); and DZHK (German Centre for Cardiovascular Research) partner site, Mannheim, Germany (C.D., M.B., S.O.S., T.P.).
authors.forename: Christina
authors.initials: C
authors.lastname: Dösch
authors.affiliation: From the Institute of Clinical Radiology and Nuclear Medicine (S.S., T.H., H.H., S.O.S.) and 1st Department of Medicine (C.D., M.B., T.P.), University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany; MR Product Innovation and Definition, Siemens Healthcare, Erlangen, Germany (M.O.Z., M.S.); Imaging and Computer Vision, Siemens AG, Corporate Technology, Princeton, NJ (M.S.N.); and DZHK (German Centre for Cardiovascular Research) partner site, Mannheim, Germany (C.D., M.B., S.O.S., T.P.).
authors.forename: Michael O
authors.initials: MO
authors.lastname: Zenge
authors.affiliation: From the Institute of Clinical Radiology and Nuclear Medicine (S.S., T.H., H.H., S.O.S.) and 1st Department of Medicine (C.D., M.B., T.P.), University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany; MR Product Innovation and Definition, Siemens Healthcare, Erlangen, Germany (M.O.Z., M.S.); Imaging and Computer Vision, Siemens AG, Corporate Technology, Princeton, NJ (M.S.N.); and DZHK (German Centre for Cardiovascular Research) partner site, Mannheim, Germany (C.D., M.B., S.O.S., T.P.).
authors.forename: Michaela
authors.initials: M
authors.lastname: Schmidt
authors.affiliation: From the Institute of Clinical Radiology and Nuclear Medicine (S.S., T.H., H.H., S.O.S.) and 1st Department of Medicine (C.D., M.B., T.P.), University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany; MR Product Innovation and Definition, Siemens Healthcare, Erlangen, Germany (M.O.Z., M.S.); Imaging and Computer Vision, Siemens AG, Corporate Technology, Princeton, NJ (M.S.N.); and DZHK (German Centre for Cardiovascular Research) partner site, Mannheim, Germany (C.D., M.B., S.O.S., T.P.).
authors.forename: Mariappan S
authors.initials: MS
authors.lastname: Nadar
authors.affiliation: From the Institute of Clinical Radiology and Nuclear Medicine (S.S., T.H., H.H., S.O.S.) and 1st Department of Medicine (C.D., M.B., T.P.), University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany; MR Product Innovation and Definition, Siemens Healthcare, Erlangen, Germany (M.O.Z., M.S.); Imaging and Computer Vision, Siemens AG, Corporate Technology, Princeton, NJ (M.S.N.); and DZHK (German Centre for Cardiovascular Research) partner site, Mannheim, Germany (C.D., M.B., S.O.S., T.P.).
authors.forename: Martin
authors.initials: M
authors.lastname: Borggrefe
authors.affiliation: From the Institute of Clinical Radiology and Nuclear Medicine (S.S., T.H., H.H., S.O.S.) and 1st Department of Medicine (C.D., M.B., T.P.), University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany; MR Product Innovation and Definition, Siemens Healthcare, Erlangen, Germany (M.O.Z., M.S.); Imaging and Computer Vision, Siemens AG, Corporate Technology, Princeton, NJ (M.S.N.); and DZHK (German Centre for Cardiovascular Research) partner site, Mannheim, Germany (C.D., M.B., S.O.S., T.P.).
authors.forename: Stefan O
authors.initials: SO
authors.lastname: Schoenberg
authors.affiliation: From the Institute of Clinical Radiology and Nuclear Medicine (S.S., T.H., H.H., S.O.S.) and 1st Department of Medicine (C.D., M.B., T.P.), University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany; MR Product Innovation and Definition, Siemens Healthcare, Erlangen, Germany (M.O.Z., M.S.); Imaging and Computer Vision, Siemens AG, Corporate Technology, Princeton, NJ (M.S.N.); and DZHK (German Centre for Cardiovascular Research) partner site, Mannheim, Germany (C.D., M.B., S.O.S., T.P.).
authors.forename: Theano
authors.initials: T
authors.lastname: Papavassiliu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D062485:Breath Holding; D055424:Cardiac-Gated Imaging Techniques; D016022:Case-Control Studies; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000503:physiopathology; D016277:Ventricular Function, Left / Q000502:physiology*