title: A Flexible Terpyridine Derivative Interacts Specifically with G-Quadruplexes.
abstract: G-quadruplexes formed by nucleic acids are implicated in pathologies ranging from cancers to neurodegenerative diseases. We evaluated interactions of 29 bi- and terpyridine derivatives with G-quadruplexes and duplexes. FRET-melting, circular dichroism, and (1) H NMR spectroscopy showed that one terpyridine derivative interacted very selectively with G-quadruplexes. This G-quadruplex ligand inhibited helicase activity and should influence G-quadruplex-related biological processes.
authors.affiliation: ARNA laboratory, Inserm U1212, CNRS UMR 5320, Institut Européen de Chimie et Biologie IECB -, Université de Bordeaux, 2 rue Robert Escarpit, 33607, Pessac, France.
authors.forename: Aurore
authors.initials: A
authors.lastname: De Rache
authors.affiliation: ARNA laboratory, Inserm U1212, CNRS UMR 5320, Institut Européen de Chimie et Biologie IECB -, Université de Bordeaux, 2 rue Robert Escarpit, 33607, Pessac, France.
authors.forename: Nassima Meriem
authors.initials: NM
authors.lastname: Gueddouda
authors.affiliation: ARNA laboratory, Inserm U1212, CNRS UMR 5320, Institut Européen de Chimie et Biologie IECB -, Université de Bordeaux, 2 rue Robert Escarpit, 33607, Pessac, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Bourdoncle
authors.affiliation: Institut für Chemie und Biochemie, Freie Universität Berlin, Takustrasse 3, 14195, Berlin, Germany.
authors.forename: Paul
authors.initials: P
authors.lastname: Hommes
authors.affiliation: Institut für Chemie und Biochemie, Freie Universität Berlin, Takustrasse 3, 14195, Berlin, Germany.
authors.forename: Hans-Ulrich
authors.initials: HU
authors.lastname: Reissig
authors.affiliation: ARNA laboratory, Inserm U1212, CNRS UMR 5320, Institut Européen de Chimie et Biologie IECB -, Université de Bordeaux, 2 rue Robert Escarpit, 33607, Pessac, France. jean-louis.mergny@inserm.fr.
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Mergny
mesh_terms: D002942:Circular Dichroism; D054856:G-Quadruplexes; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D011725:Pyridines / Q000737:chemistry*
chemical_list: D008024:Ligands; D011725:Pyridines
keywords: G-quadruplex; G4 ligand; bipyridine; helicase; terpyridine