title: Long noncoding RNAs and Alzheimer's disease.
abstract: Long noncoding RNAs (lncRNAs) are typically defined as transcripts longer than 200 nucleotides. lncRNAs can regulate gene expression at epigenetic, transcriptional, and posttranscriptional levels. Recent studies have shown that lncRNAs are involved in many neurological diseases such as epilepsy, neurodegenerative conditions, and genetic disorders. Alzheimer's disease is a neurodegenerative disease, which accounts for >80% of dementia in elderly subjects. In this review, we will highlight recent studies investigating the role of lncRNAs in Alzheimer's disease and focus on some specific lncRNAs that may underlie Alzheimer's disease pathophysiology and therefore could be potential therapeutic targets.
authors.affiliation: Department of Neurology, Jinshan Hospital; Department of Neurology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Luo
authors.affiliation: Department of Neurology, Jinshan Hospital; Department of Neurology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
authors.forename: Yinghui
authors.initials: Y
authors.lastname: Chen
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics*; D016229:Amyloid beta-Peptides / Q000235:genetics*; D015870:Gene Expression; D006801:Humans; D062085:RNA, Long Noncoding / Q000235:genetics*; D022661:RNA, Untranslated / Q000235:genetics
chemical_list: C567939:17A non-coding RNA, human; D016229:Amyloid beta-Peptides; C561565:BACE1-AS long non-coding RNA, human; C576282:NDM29 non-coding RNA, human; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; C000609640:long non-coding RNA BC200, human
keywords: Alzheimer’s disease; BACE1; BACE1-AS; BC200; amyloid β peptide; lncRNA; ncRNAs