title: [Maternal serum 25-hydroxy vitamin D levels in the first trimester and adverse gestational outcomes].
abstract: BACKGROUND
  Some disorders of pregnancy and newborn have been associated with vitamin D deficiency (25 (OH) D) in maternal serum. The pathophysiology of this relationship is unknown today.
  
  
  OBJECTIVE
  The aim of this study was to determine whether serum levels of vitamin D at the beginning of pregnancy are associated with gestational diabetes, hypertensive disorders of pregnancy, preterm birth and fetal growth restriction.
  
  
  METHODS
  We conducted a prospective cohort study in 370 pregnant women at low obstetric risk randomly selected in our area (latitude 42 ° 20'N). The level of 25-hydroxy vitamin D was determinate between 8 and 14 weeks of pregnancy. We studied the relationship between the status of vitamin D and gestational diabetes, preeclampsia, preterm birth, intrauterine growth restriction and small for gestational age. The statistic analysis was performed using SPSS 15.0 and 3.1 Epidat programs.
  
  
  RESULTS
  The prevalence of vitamin D deficiency in pregnant women in this serie was 96.8%, 34.6% had severe deficiency. After adjusting for maternal and seasonal variables, we haven't found association between first trimester maternal serum vitamin D levels and pregnancy outcomes studied.
  
  
  CONCLUSIONS
  The pregnancy outcome was independent of the first trimester maternal serum 25(OH)D status.
authors.forename: E
authors.initials: E
authors.lastname: Álvarez-Silvares
authors.forename: M
authors.initials: M
authors.lastname: Vilouta-Romero
authors.forename: E
authors.initials: E
authors.lastname: Borrajo-Hernández
authors.forename: M L
authors.initials: ML
authors.lastname: Morales-Serrano
authors.forename: M T
authors.initials: MT
authors.lastname: Alves-Pérez
mesh_terms: D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood* / Q000453:epidemiology; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First; D015995:Prevalence; D011446:Prospective Studies; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood* / Q000453:epidemiology; D055815:Young Adult
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D