title: [Prognostic factors of penis-sparing surgery for early-stage penile cancer].
abstract: OBJECTIVE
  To investigate the factors influencing the prognosis of penis-sparing surgery (PSS) for early-stage penile cancer.
  
  
  METHODS
  We retrospectively studied the clinical data about 45 cases of early-stage penile cancer treated by PSS from January 2007 to December 2014. We calculated the rate of local recurrence-free survival by the Kaplan-Meier method, and conducted univariate and multivariate COX regression analyses on the relevant factors including the patient's age, marital status, tumor location, tumor size, postoperative sexual life, histological grade, and TNM stage.
  
  
  RESULTS
  One-year and three-year local recurrence-free survival rates were 95.5% and 52.2%, respectively. Multivariate analysis demonstrated that the histological grade (P = 0.039) and postoperative sexual life (P = 0.049) were independent factors for the prognosis of PSS. Logistic regression showed the patients age to be significantly associated with histological grade (P = 0.014).
  
  
  CONCLUSIONS
  Histological grade and postoperative sexual life are important independent prognostic factors of PSS for early-stage penile cancer, and the patients age is associated with the prognosis of PSS through its influence on the tumor grade.
authors.forename: Jia-yi
authors.initials: JY
authors.lastname: Zhang
authors.forename: Le-bin
authors.initials: LB
authors.lastname: Song
authors.forename: Ya-min
authors.initials: YM
authors.lastname: Wang
authors.forename: Chen
authors.initials: C
authors.lastname: Chen
authors.forename: Yi-chun
authors.initials: YC
authors.lastname: Wang
authors.forename: Ning-hong
authors.initials: NH
authors.lastname: Song
authors.forename: Min
authors.initials: M
authors.lastname: Gu
mesh_terms: D000367:Age Factors; D018572:Disease-Free Survival; D006801:Humans; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D060787:Neoplasm Grading; D059351:Organ Sparing Treatments; D010412:Penile Neoplasms / Q000601:surgery*; D010413:Penis / Q000601:surgery*; D011379:Prognosis; D016016:Proportional Hazards Models; D011788:Quality of Life; D012189:Retrospective Studies