title: Highly stable and self-repairing membrane-mimetic 2D nanomaterials assembled from lipid-like peptoids.
abstract: An ability to develop sequence-defined synthetic polymers that both mimic lipid amphiphilicity for self-assembly of highly stable membrane-mimetic 2D nanomaterials and exhibit protein-like functionality would revolutionize the development of biomimetic membranes. Here we report the assembly of lipid-like peptoids into highly stable, crystalline, free-standing and self-repairing membrane-mimetic 2D nanomaterials through a facile crystallization process. Both experimental and molecular dynamics simulation results show that peptoids assemble into membranes through an anisotropic formation process. We further demonstrated the use of peptoid membranes as a robust platform to incorporate and pattern functional objects through large side-chain diversity and/or co-crystallization approaches. Similar to lipid membranes, peptoid membranes exhibit changes in thickness upon exposure to external stimuli; they can coat surfaces in single layers and self-repair. We anticipate that this new class of membrane-mimetic 2D nanomaterials will provide a robust matrix for development of biomimetic membranes tailored to specific applications.
authors.affiliation: Division of Physical Sciences, Pacific Northwest National Laboratory, Richland, Washington 99352, USA.
authors.forename: Haibao
authors.initials: H
authors.lastname: Jin
authors.affiliation: Division of Physical Sciences, Pacific Northwest National Laboratory, Richland, Washington 99352, USA.|School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Jiao
authors.affiliation: Division of Physical Sciences, Pacific Northwest National Laboratory, Richland, Washington 99352, USA.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Daily
authors.affiliation: Division of Physical Sciences, Pacific Northwest National Laboratory, Richland, Washington 99352, USA.
authors.forename: Yulin
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Division of Physical Sciences, Pacific Northwest National Laboratory, Richland, Washington 99352, USA.|College of Chemistry and Chemical Engineering, Linyi University, Linyi, Shandong 276005, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Yan
authors.affiliation: Division of Physical Sciences, Pacific Northwest National Laboratory, Richland, Washington 99352, USA.|Institute of Rheology Mechanics, Xiangtan University, Xiangtan, Hunan 411105, China.
authors.forename: Yan-Huai
authors.initials: YH
authors.lastname: Ding
authors.affiliation: Division of Physical Sciences, Pacific Northwest National Laboratory, Richland, Washington 99352, USA.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.
authors.forename: Ellen J
authors.initials: EJ
authors.lastname: Robertson
authors.affiliation: Division of Physical Sciences, Pacific Northwest National Laboratory, Richland, Washington 99352, USA.
authors.forename: Marcel D
authors.initials: MD
authors.lastname: Baer
authors.affiliation: Division of Physical Sciences, Pacific Northwest National Laboratory, Richland, Washington 99352, USA.
authors.forename: Chun-Long
authors.initials: CL
authors.lastname: Chen
mesh_terms: D040761:Biomimetic Materials; D002462:Cell Membrane / Q000737:chemistry*; D003460:Crystallization; D008055:Lipids; D056004:Molecular Dynamics Simulation; D049329:Nanostructures / Q000737:chemistry*; D034444:Peptoids / Q000737:chemistry*
chemical_list: D008055:Lipids; D034444:Peptoids