title: Body mass index and adiposity indicators associated with cardiovascular biomarkers in youth with type 1 diabetes followed prospectively.
abstract: The impact of excess weight on cardiovascular disease risk in type 1 diabetes patients is unclear.
  
  
  
  This study examined associations of BMI and body composition with cardiovascular risk factors in youth followed prospectively for 18 months.
  
  
  
  The sample includes youth with type 1 diabetes (N = 136, baseline age = 12.3 ± 2.5y, glycated hemoglobin = 8.1 ± 1.1%) participating in an 18-month behavioral nutrition intervention trial. BMI, body composition (by dual energy x-ray absorptiometry), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C); triglycerides (TG), c-reactive protein (CRP), 8-iso-prostaglandin-F2alpha (8-iso-PGF2α), adiponectin and systolic and diastolic blood pressure (SBP and DBP, respectively) were assessed at clinic visits every 6 months. Random effects regression models for repeated measures estimated associations of time-varying BMI and body composition with time-varying cardiovascular risk factors, adjusted for treatment assignment and covariates.
  
  
  
  There was no intervention effect on cardiovascular risk factors. Percent body fat was positively associated with TG, LDL-C, CRP, SBP and DBP, while trunk fat mass and trunk %fat were associated positively with TG, LDL-C, CRP, SBP and DBP, and inversely with HDL-C. Higher BMI was associated with greater TG, CRP, SBP and DBP and lower HDL-C. BMI and body composition indicators were unrelated to 8-iso-PGF2α and adiponectin.
  
  
  
  Excess adiposity is associated with increased cardiovascular risk factors in this sample of youth with type 1 diabetes. Non-significant associations with adiponectin and 8-iso-PGF2α suggest potential differences from the general population in the role of adiposity in cardiovascular health.
authors.affiliation: Health Behavior Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, North Bethesda, MD, USA.
authors.forename: L M
authors.identifier: 0000-0003-2645-4388
authors.initials: LM
authors.lastname: Lipsky
authors.affiliation: Health Behavior Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, North Bethesda, MD, USA.
authors.forename: B
authors.initials: B
authors.lastname: Gee
authors.affiliation: Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.
authors.forename: A
authors.initials: A
authors.lastname: Liu
authors.affiliation: Health Behavior Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, North Bethesda, MD, USA.
authors.forename: T R
authors.initials: TR
authors.lastname: Nansel
mesh_terms: D015502:Absorptiometry, Photon; D050154:Adiposity / Q000502:physiology*; D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000502:physiology; D001823:Body Composition / Q000502:physiology; D015992:Body Mass Index; D002097:C-Reactive Protein; D002318:Cardiovascular Diseases / Q000209:etiology*; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000175:diagnosis; D015237:Dinoprost / Q000031:analogs & derivatives / Q000097:blood; D005260:Female; D006442:Glycated Hemoglobin; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D009765:Obesity / Q000150:complications*; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D015237:Dinoprost; D006442:Glycated Hemoglobin; D008055:Lipids; C075750:8-epi-prostaglandin F2alpha
keywords: blood pressure; body composition; children and adolescents; inflammation; oxidative stress; serum lipids; type 1 diabetes