title: [Giant inflammatory pseudotumor of the cranial base].
abstract: The inflammatory pseudotumour (IPT) is a non-neoplastic entity of unknown origin, and is characterised by a proliferation of connective tissue and a polyclonal inflammatory infiltrate. Central nervous system involvement is uncommon, and usually represents a diagnostic and therapeutic challenge even for the experienced clinician. This reports deals with the case of a 56year-old woman diagnosed with a giant, infiltrating mass centred in the left cavernous sinus, who had a rapid clinical and radiological response to steroid therapy. Biopsy specimens were diagnostic for IPT. The progression of a small orbital residual lesion was detected after steroid withdrawal. Treatment with cyclophosphamide induced a complete response that remains stable after six years of follow-up.
authors.affiliation: Servicio de Neurocirugía, Hospital Universitario Ramón y Cajal, Madrid, España. Electronic address: rocamo@gmail.com.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Carrasco-Moro
authors.affiliation: Servicio de Radiodiagnóstico, Hospital Universitario Ramón y Cajal, Madrid, España.
authors.forename: Juan
authors.initials: J
authors.lastname: Martínez-San Millán
authors.affiliation: Servicio de Anatomía Patológica, Hospital Universitario Ramón y Cajal, Madrid, España.
authors.forename: Héctor
authors.initials: H
authors.lastname: Pian
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D002426:Cavernous Sinus; D018450:Disease Progression; D005260:Female; D006104:Granuloma, Plasma Cell / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D019291:Skull Base / Q000473:pathology*
chemical_list: D000305:Adrenal Cortex Hormones
keywords: Base del cráneo; Cavernous sinus; Granuloma de células plasmáticas; Inflammatory pseudotumour; Plasma cell granuloma; Pseudotumor inflamatorio; Seno cavernoso; Skull base