title: Hydrogen Sulfide Mitigates Kidney Injury in High Fat Diet-Induced Obese Mice.
abstract: Obesity is prevalent worldwide and is a major risk factor for the development and progression of kidney disease. Hydrogen sulfide (H2S) plays an important role in renal physiological and pathophysiological processes. However, whether H2S is able to mitigate kidney injury induced by obesity in mice remains unclear. In this study, we demonstrated that H2S significantly reduced the accumulation of lipids in the kidneys of high fat diet- (HFD-) induced obese mice. The results of hematoxylin and eosin, periodic acid-Schiff, and Masson's trichrome staining showed that H2S ameliorated the kidney structure, decreased the extent of interstitial injury, and reduced the degree of kidney fibrosis in HFD-induced obese mice. We found that H2S decreased the expression levels of tumor necrosis factor-α, interleukin- (IL-) 6, and monocyte chemoattractant protein-1 but increased the expression level of IL-10. Furthermore, H2S treatment decreased the protein expression of p50, p65, and p-p65 in the kidney of HFD-induced obese mice. In conclusion, H2S is able to mitigate renal injury in HFD-induced obese mice through the reduction of kidney inflammation by downregulating the expression of nuclear factor-kappa B. H2S or its releasing compounds may serve as a potential therapeutic molecule for obesity-induced kidney injury.
authors.affiliation: School of Medicine, Henan University, Kaifeng, Henan 475004, China.
authors.forename: Dongdong
authors.initials: D
authors.lastname: Wu
authors.affiliation: School of Medicine, Henan University, Kaifeng, Henan 475004, China; Kaifeng Central Hospital, Kaifeng, Henan 475000, China.
authors.forename: Biao
authors.initials: B
authors.lastname: Gao
authors.affiliation: School of Medicine, Henan University, Kaifeng, Henan 475004, China.
authors.forename: Mengling
authors.initials: M
authors.lastname: Li
authors.affiliation: School of Medicine, Henan University, Kaifeng, Henan 475004, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Yao
authors.affiliation: School of Medicine, Henan University, Kaifeng, Henan 475004, China.
authors.forename: Shuaiwei
authors.initials: S
authors.lastname: Wang
authors.affiliation: School of Medicine, Henan University, Kaifeng, Henan 475004, China.
authors.forename: Mingliang
authors.initials: M
authors.lastname: Chen
authors.affiliation: School of Medicine, Henan University, Kaifeng, Henan 475004, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.affiliation: Kaifeng Central Hospital, Kaifeng, Henan 475000, China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Ma
authors.affiliation: School of Medicine, Henan University, Kaifeng, Henan 475004, China.
authors.forename: Ailing
authors.identifier: 0000-0003-0166-5226
authors.initials: A
authors.lastname: Ji
authors.affiliation: School of Medicine, Henan University, Kaifeng, Henan 475004, China.
authors.forename: Yanzhang
authors.identifier: 0000-0002-7327-0015
authors.initials: Y
authors.lastname: Li
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology*; D000818:Animals; D059305:Diet, High-Fat; D006862:Hydrogen Sulfide / Q000009:adverse effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D009765:Obesity / Q000150:complications*; D012307:Risk Factors
chemical_list: D006862:Hydrogen Sulfide