title: Antisynthetase syndrome: Pulmonary computed tomography findings of adult patients with antibodies to aminoacyl-tRNA synthetases.
abstract: OBJECTIVE
  To describe the pulmonary CT findings in patients with anti-ARS-antibody-positive interstitial lung disease (anti-ARS-ILD) METHODS: The CT findings of 64 patients with anti-ARS-ILD were retrospectively reviewed. The images were retrospectively reviewed independently by 2 chest radiologists, and the final decision on the CT findings was made by a third chest radiologist.
  
  
  RESULTS
  There were 16 male and 48 female patients, aged 54.2±13.4 years. Sixteen patients had anti Jo-1, 24 had anti-EJ, 9 had anti-PL-7, 7 had anti-PL-12, 5 had anti-KS, and 3 had anti-OJ antibodies. Overall, 63 patients (98.4%) had CT findings predominantly in the lower lobe; 61 patients (95.3%) showed peripheral opacities, and 47 patients (73.4%) showed peribronchovascular opacities. Ground-glass attenuation, consolidation, and reticulation showed similar distribution patterns. Regarding detailed CT findings, 89.1% of patients had lower volume loss, 76.6% had interlobular septal thickening, and 67.2% had thickening of bronchovascular bundles. The final radiologic diagnoses were as follows: inconsistent with usual interstitial pneumonia (UIP) in 63 patients (98.4%), which included nonspecific interstitial pneumonia (NSIP) in 35 patients (55.6%), organizing pneumonia (OP) in 4 patients (6.3%), and OP with fibrosis in 22 patients (34.9%).
  
  
  CONCLUSIONS
  The characteristic CT findings of patients with anti-ARS-ILD were areas of ground-glass attenuation and reticulation, predominantly distributed as lower and peribronchovascular lesions, which is compatible with NSIP. One-third of patients showed OP with fibrosis.
authors.affiliation: From the Department of Respiratory Medicine, Japan Community Health care Organization Kanazawa Hospital, Ha-15, Oki-machi, Kanazawa, Ishikawa 920-8641, Japan. Electronic address: yuwaseda@gmail.com.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Waseda
authors.affiliation: From the Department of Respiratory Medicine, Japan Community Health care Organization Kanazawa Hospital, Ha-15, Oki-machi, Kanazawa, Ishikawa 920-8641, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Johkoh
authors.affiliation: From the Department of Respiratory Medicine, Japan Community Health care Organization Kanazawa Hospital, Ha-15, Oki-machi, Kanazawa, Ishikawa 920-8641, Japan.
authors.forename: Ryoko
authors.initials: R
authors.lastname: Egashira
authors.affiliation: From the Department of Respiratory Medicine, Japan Community Health care Organization Kanazawa Hospital, Ha-15, Oki-machi, Kanazawa, Ishikawa 920-8641, Japan.
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Sumikawa
authors.affiliation: From the Department of Respiratory Medicine, Japan Community Health care Organization Kanazawa Hospital, Ha-15, Oki-machi, Kanazawa, Ishikawa 920-8641, Japan.
authors.forename: Keigo
authors.initials: K
authors.lastname: Saeki
authors.affiliation: From the Department of Respiratory Medicine, Japan Community Health care Organization Kanazawa Hospital, Ha-15, Oki-machi, Kanazawa, Ishikawa 920-8641, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Watanabe
authors.affiliation: From the Department of Respiratory Medicine, Japan Community Health care Organization Kanazawa Hospital, Ha-15, Oki-machi, Kanazawa, Ishikawa 920-8641, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Matsunuma
authors.affiliation: From the Department of Respiratory Medicine, Japan Community Health care Organization Kanazawa Hospital, Ha-15, Oki-machi, Kanazawa, Ishikawa 920-8641, Japan.
authors.forename: Hazuki
authors.initials: H
authors.lastname: Takato
authors.affiliation: From the Department of Respiratory Medicine, Japan Community Health care Organization Kanazawa Hospital, Ha-15, Oki-machi, Kanazawa, Ishikawa 920-8641, Japan.
authors.forename: Yukari
authors.initials: Y
authors.lastname: Ichikawa
authors.affiliation: From the Department of Respiratory Medicine, Japan Community Health care Organization Kanazawa Hospital, Ha-15, Oki-machi, Kanazawa, Ishikawa 920-8641, Japan.
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Hamaguchi
authors.affiliation: From the Department of Respiratory Medicine, Japan Community Health care Organization Kanazawa Hospital, Ha-15, Oki-machi, Kanazawa, Ishikawa 920-8641, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Shiraki
authors.affiliation: From the Department of Respiratory Medicine, Japan Community Health care Organization Kanazawa Hospital, Ha-15, Oki-machi, Kanazawa, Ishikawa 920-8641, Japan.
authors.forename: Yoshinao
authors.initials: Y
authors.lastname: Muro
authors.affiliation: From the Department of Respiratory Medicine, Japan Community Health care Organization Kanazawa Hospital, Ha-15, Oki-machi, Kanazawa, Ishikawa 920-8641, Japan.
authors.forename: Masahide
authors.initials: M
authors.lastname: Yasui
authors.affiliation: From the Department of Respiratory Medicine, Japan Community Health care Organization Kanazawa Hospital, Ha-15, Oki-machi, Kanazawa, Ishikawa 920-8641, Japan.
authors.forename: Helmut
authors.initials: H
authors.lastname: Prosch
authors.affiliation: From the Department of Respiratory Medicine, Japan Community Health care Organization Kanazawa Hospital, Ha-15, Oki-machi, Kanazawa, Ishikawa 920-8641, Japan.
authors.forename: Christian
authors.initials: C
authors.lastname: Herold
authors.affiliation: From the Department of Respiratory Medicine, Japan Community Health care Organization Kanazawa Hospital, Ha-15, Oki-machi, Kanazawa, Ishikawa 920-8641, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kasahara
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000604:Amino Acyl-tRNA Synthetases / Q000097:blood / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009220:Myositis / Q000097:blood / Q000000981:diagnostic imaging* / Q000276:immunology*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D000604:Amino Acyl-tRNA Synthetases
keywords: Aminoacyl-tRNA synthetases; Antisynthetase syndrome; Dermatomyositis; Interstitial lung disease; Polymyositis