title: Comparison of Rai and Binet Classifications in Chronic Lymphocytic Leukemia.
abstract: Staging systems are essential for understanding disease, in predicting the outcome, and therapeutic decision making in any tumor as well as chronic lymphocytic leukemia (CLL). In this study, we compared the clinical correlation of the Rai and Binet classification systems in 133 CLL patients. The distribution of 133 patients according to the Rai system was as follows, stage 0:17, I:13, II:45, III:30, IV:28, and in the Binet system stage A:35, B:40, C:58 patients. Median survival of patients according to the Rai staging system was >67.0, >91.0, 63.8, 20.9 and 9.8 months, and >91.0, 63.4, 16.0 months according to Binet, respectively. Although no difference was found between Rai stages 0, I, II (p > 0.05) in terms of median survival, the difference between these stages and stages III and IV was statistically significant (p < 0.05). In the Binet staging system statistically significant survival difference was found between all stages (p < 0.05). We concluded that although both systems are comparable in terms of staging and predicting the outcome of patients with CLL, the Rai staging system appears to have an advantage over the Binet system by defining a subset of patients with excellent prognosis (stage 0) which is included within stage A of the latter.
authors.affiliation: a Hacettepe University Institute of Oncology , Division of Medical Oncology Hacettepe University Faculty of Medicine Department of Internal Medicine, Division of Hematology.
authors.forename: N
authors.initials: N
authors.lastname: Zengin
authors.affiliation: a Hacettepe University Institute of Oncology , Division of Medical Oncology Hacettepe University Faculty of Medicine Department of Internal Medicine, Division of Hematology.
authors.forename: A
authors.initials: A
authors.lastname: Kars
authors.affiliation: a Hacettepe University Institute of Oncology , Division of Medical Oncology Hacettepe University Faculty of Medicine Department of Internal Medicine, Division of Hematology.
authors.forename: E
authors.initials: E
authors.lastname: Kansu
authors.affiliation: b Hacettepe University Faculty of Medicine Department of Internal Medicine, Division of Hematology.
authors.forename: O
authors.initials: O
authors.lastname: Özdemir
authors.affiliation: a Hacettepe University Institute of Oncology , Division of Medical Oncology Hacettepe University Faculty of Medicine Department of Internal Medicine, Division of Hematology.
authors.forename: İ
authors.initials: İ
authors.lastname: Barişta
authors.affiliation: a Hacettepe University Institute of Oncology , Division of Medical Oncology Hacettepe University Faculty of Medicine Department of Internal Medicine, Division of Hematology.
authors.forename: İ
authors.initials: İ
authors.lastname: Güllü
authors.affiliation: a Hacettepe University Institute of Oncology , Division of Medical Oncology Hacettepe University Faculty of Medicine Department of Internal Medicine, Division of Hematology.
authors.forename: N
authors.initials: N
authors.lastname: Güler
authors.affiliation: a Hacettepe University Institute of Oncology , Division of Medical Oncology Hacettepe University Faculty of Medicine Department of Internal Medicine, Division of Hematology.
authors.forename: Y
authors.initials: Y
authors.lastname: Özişik
authors.affiliation: b Hacettepe University Faculty of Medicine Department of Internal Medicine, Division of Hematology.
authors.forename: S
authors.initials: S
authors.lastname: Dündar
authors.affiliation: a Hacettepe University Institute of Oncology , Division of Medical Oncology Hacettepe University Faculty of Medicine Department of Internal Medicine, Division of Hematology.
authors.forename: D
authors.initials: D
authors.lastname: Firat
keywords: Chronic Lymphocytic Leukemia; Classification; Staging