title: Poly(sebacoyl diglyceride) Cross-Linked by Dynamic Hydrogen Bonds: A Self-Healing and Functionalizable Thermoplastic Bioelastomer.
abstract: Biodegradable and biocompatible elastomers (bioelastomers) could resemble the mechanical properties of extracellular matrix and soft tissues and, thus, are very useful for many biomedical applications. Despite significant advances, tunable bioelastomers with easy processing, facile biofunctionalization, and the ability to withstand a mechanically dynamic environment have remained elusive. Here, we reported new dynamic hydrogen-bond cross-linked PSeD-U bioelastomers possessing the aforementioned features by grafting 2-ureido-4[1H]-pyrimidinones (UPy) units with strong self-complementary quadruple hydrogen bonds to poly(sebacoyl diglyceride) (PSeD), a refined version of a widely used bioelastomer poly(glycerol sebacate) (PGS). PSeD-U polymers exhibited stronger mechanical strength than their counterparts of chemically cross-linked PSeD and tunable elasticity by simply varying the content of UPy units. In addition to the good biocompatibility and biodegradability as seen in PSeD, PSeD-U showed fast self-healing (within 30 min) at mild conditions (60 °C) and could be readily processed at moderate temperature (90-100 °C) or with use of solvent casting at room temperature. Furthermore, the free hydroxyl groups of PSeD-U enabled facile functionalization, which was demonstrated by the modification of PSeD-U film with FITC as a model functional molecule.
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University , 2999 North Renmin Road, Shanghai 201620, People's Republic of China.
authors.forename: Shuo
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Ophthalmology, Shanghai Ninth Peoples' Hospital affiliated to Shanghai Jiao Tong University, School of Medicine , 639 Zhizaoju Road, Shanghai 200011, People's Republic of China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Bi
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University , 2999 North Renmin Road, Shanghai 201620, People's Republic of China.
authors.forename: Lijie
authors.initials: L
authors.lastname: Sun
authors.affiliation: Departments of Bioengineering, Chemical Engineering, Surgery, and the McGowan Institute, University of Pittsburgh , 3700 O'Hara Street, Pittsburgh, Pennsylvania 15261, United States.
authors.forename: Jin
authors.initials: J
authors.lastname: Gao
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University , 2999 North Renmin Road, Shanghai 201620, People's Republic of China.
authors.forename: Peng
authors.initials: P
authors.lastname: Huang
authors.affiliation: Department of Ophthalmology, Shanghai Ninth Peoples' Hospital affiliated to Shanghai Jiao Tong University, School of Medicine , 639 Zhizaoju Road, Shanghai 200011, People's Republic of China.
authors.forename: Xianqun
authors.initials: X
authors.lastname: Fan
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University , 2999 North Renmin Road, Shanghai 201620, People's Republic of China.
authors.forename: Zhengwei
authors.initials: Z
authors.lastname: You
authors.affiliation: Departments of Bioengineering, Chemical Engineering, Surgery, and the McGowan Institute, University of Pittsburgh , 3700 O'Hara Street, Pittsburgh, Pennsylvania 15261, United States.
authors.forename: Yadong
authors.initials: Y
authors.lastname: Wang
keywords: bioelastomer; dynamic polymer; functionalization; hydrogen bonds; self-healing