title: Diagnostic Accuracy of Five Different Fecal Markers for the Detection of Precancerous and Cancerous Lesions of the Colorectum.
abstract: Background. Colorectal cancer (CRC) is the second deadliest malignancy worldwide. This study aimed to compare the diagnostic accuracy of different fecal markers in the detection of colorectal adenomas and cancer. Methods. Stool samples of patients referred to colonoscopy were collected for the analysis of tumor M2 pyruvate kinase (M2PK), human hemoglobin (Hb), hemoglobin/haptoglobin (Hb/Hp) complex, fecal calprotectin (FC), and matrix metalloproteinase-9 (MMP-9). Results. Sensitivity and specificity of M2PK for adenomas sized > 1 cm were 60% and 67.5% and for CRC were 94.7% and 67.5%. Sensitivity and specificity of iFOBT for adenomas sized ≥ 1 cm were 80% and 72.5% and for CRC were 94.7% and 72.5%. Sensitivity and specificity of Hb/Hp complex for adenomas sized ≥ 1 cm were 80% and 52.9% and for CRC were 100% and 52.9%. Sensitivity of FC and MMP-9 for CRC was 77.8% and 72.2%. Combined use of M2PK, iFOBT, and FC resulted in a sensitivity and specificity of 95% and 47.5% for the detection of adenomas sized ≥ 1 cm. Discussion. In CRC, sensitivity of M2PK, iFOBT, and Hb/Hp complex proved to be high. Combined use of M2PK, iFOBT, and FC may be valuable in the detection of large adenomas.
authors.affiliation: First Department of Medicine, University of Szeged, Korányi Fasor 8-10, Szeged 6720, Hungary.
authors.forename: Mariann
authors.initials: M
authors.lastname: Rutka
authors.affiliation: First Department of Medicine, University of Szeged, Korányi Fasor 8-10, Szeged 6720, Hungary.
authors.forename: Renáta
authors.initials: R
authors.lastname: Bor
authors.affiliation: First Department of Medicine, University of Szeged, Korányi Fasor 8-10, Szeged 6720, Hungary.
authors.forename: Anita
authors.identifier: 0000-0002-3624-896X
authors.initials: A
authors.lastname: Bálint
authors.affiliation: First Department of Medicine, University of Szeged, Korányi Fasor 8-10, Szeged 6720, Hungary.
authors.forename: Anna
authors.identifier: 0000-0002-0824-7476
authors.initials: A
authors.lastname: Fábián
authors.affiliation: First Department of Medicine, University of Szeged, Korányi Fasor 8-10, Szeged 6720, Hungary.
authors.forename: Ágnes
authors.initials: Á
authors.lastname: Milassin
authors.affiliation: First Department of Medicine, University of Szeged, Korányi Fasor 8-10, Szeged 6720, Hungary.
authors.forename: Ferenc
authors.initials: F
authors.lastname: Nagy
authors.affiliation: First Department of Medicine, University of Szeged, Korányi Fasor 8-10, Szeged 6720, Hungary.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Szepes
authors.affiliation: Department of Medical Physics and Informatics, University of Szeged, Korányi Fasor 9, Szeged 6720, Hungary.
authors.forename: Mónika
authors.initials: M
authors.lastname: Szűcs
authors.affiliation: Department of Pathology, University of Szeged, Állomás Utca 2, Szeged 6720, Hungary.
authors.forename: László
authors.initials: L
authors.lastname: Tiszlavicz
authors.affiliation: First Department of Medicine, University of Szeged, Korányi Fasor 8-10, Szeged 6720, Hungary.
authors.forename: Klaudia
authors.identifier: 0000-0003-0599-182X
authors.initials: K
authors.lastname: Farkas
authors.affiliation: First Department of Medicine, University of Szeged, Korányi Fasor 8-10, Szeged 6720, Hungary.
authors.forename: Tamás
authors.initials: T
authors.lastname: Molnár
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D005243:Feces / Q000737:chemistry*; D005260:Female; D006242:Haptoglobins / Q000032:analysis; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D039841:Leukocyte L1 Antigen Complex / Q000032:analysis; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000032:analysis; D008875:Middle Aged; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000378:metabolism; D011770:Pyruvate Kinase / Q000032:analysis; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D006242:Haptoglobins; D006454:Hemoglobins; D039841:Leukocyte L1 Antigen Complex; D011770:Pyruvate Kinase; D020780:Matrix Metalloproteinase 9