title: BAG3 Protein Is Over-Expressed in Endometrioid Endometrial Adenocarcinomas.
abstract: Endometrioid endometrial cancer is the most common gynaecological tumor in developed countries, and its incidence is increasing. The definition of subtypes, based on clinical and endocrine features or on histopathological characteristics, correlate to some extent with patient's prognosis, but there is substantial heterogeneity within tumor types. The search for molecules and mechanisms implied in determining the progression and the response to therapy for this cancer is still ongoing. BAG3 protein, a member of BAG family of co-chaperones, has a pro-survival role in several tumor types. BAG3 anti-apoptotic properties rely on its characteristic to bind several intracellular partners, thereby, modulating crucial events such as apoptosis, differentiation, cell motility, and autophagy. BAG3 expression in human endometrial cancer tissues was not investigated so far. Here, we show that BAG3 protein levels are elevated in tumoral and hyperplastic cells in respect to normal glands. Furthermore, BAG3 subcellular localization appears to be changed in tumoral compared to normal cells. Our results indicate a possible role for BAG3 protein in the maintenance of cell survival in endometrioid endometrial cancer and suggest that this field of studies is worthy of further investigations. J. Cell. Physiol. 232: 309-311, 2017. © 2016 Wiley Periodicals, Inc.
authors.affiliation: "SS. Giovanni di Dio e Ruggi d'Aragona-Schola Medica Salernitana", University of Salerno Hospital, Salerno, Italy.|Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Baronissi (SA), Italy.
authors.forename: Veronica
authors.initials: V
authors.lastname: Esposito
authors.affiliation: "SS. Giovanni di Dio e Ruggi d'Aragona-Schola Medica Salernitana", University of Salerno Hospital, Salerno, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Baldi
authors.affiliation: "SS. Giovanni di Dio e Ruggi d'Aragona-Schola Medica Salernitana", University of Salerno Hospital, Salerno, Italy.|Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Baronissi (SA), Italy.
authors.forename: Pio
authors.initials: P
authors.lastname: Zeppa
authors.affiliation: Department of Pharmacy, University of Salerno, Fisciano, Italy.|BIOUNIVERSA s.r.l., University of Salerno, Fisciano, Italy.
authors.forename: Michelina
authors.initials: M
authors.lastname: Festa
authors.affiliation: BIOUNIVERSA s.r.l., University of Salerno, Fisciano, Italy.
authors.forename: Luana
authors.initials: L
authors.lastname: Guerriero
authors.affiliation: BIOUNIVERSA s.r.l., University of Salerno, Fisciano, Italy.
authors.forename: Morena
authors.initials: M
authors.lastname: d'Avenia
authors.affiliation: BIOUNIVERSA s.r.l., University of Salerno, Fisciano, Italy.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Chetta
authors.affiliation: Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Baronissi (SA), Italy.
authors.forename: Fulvio
authors.initials: F
authors.lastname: Zullo
authors.affiliation: BIOUNIVERSA s.r.l., University of Salerno, Fisciano, Italy.|Department of Experimental and Clinical Sciences, University G. D'Annunzio and Fondazione G. D'Annunzio, Ce.S.I., Chieti, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: De Laurenzi
authors.affiliation: "SS. Giovanni di Dio e Ruggi d'Aragona-Schola Medica Salernitana", University of Salerno Hospital, Salerno, Italy.|Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Baronissi (SA), Italy.|BIOUNIVERSA s.r.l., University of Salerno, Fisciano, Italy.
authors.forename: Maria Caterina
authors.initials: MC
authors.lastname: Turco
authors.affiliation: Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Baronissi (SA), Italy. arosati@unisa.it.|BIOUNIVERSA s.r.l., University of Salerno, Fisciano, Italy. arosati@unisa.it.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Rosati
authors.affiliation: "SS. Giovanni di Dio e Ruggi d'Aragona-Schola Medica Salernitana", University of Salerno Hospital, Salerno, Italy. maguida@unisa.it.|Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Baronissi (SA), Italy. maguida@unisa.it.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Guida
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000368:Aged; D000369:Aged, 80 and over; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism*; D018269:Carcinoma, Endometrioid / Q000378:metabolism* / Q000473:pathology; D045744:Cell Line, Tumor; D016889:Endometrial Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D013194:Staining and Labeling
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D051017:Apoptosis Regulatory Proteins; C414431:BAG3 protein, human