title: The role of STAT transcription factors in apoptosis regulation of hypothalamic neurons in aging in HER-2/neu transgenic mice and wild-type FVB/N mice.
abstract: For the firsts time, the involvement of the STAT pathway in the regulation of neuronal apoptosis in physiological aging and in old mice overexpressing the HER-2/neu oncogene was studied. We showed that suppression of STAT3, STAT5, and STAT6 and overexpression of the proapoptotic factor STAT1, which provides p53-mediated apoptosis, are the causes for increasing the number of apoptotic neurons in physiological aging. HER-2 tyrosine kinase receptor overexpression promotes neuronal survival through activation of STAT-signaling pathway with simultaneous suppression of the proapoptotic factor STAT1.
authors.affiliation: Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, pr. Morisa Toreza 44, St. Petersburg, 194223, Russia. bazhanovae@mail.ru.
authors.forename: E D
authors.initials: ED
authors.lastname: Bazhanova
authors.affiliation: Petrov Research Institute of Oncology, ul. Leningradskaya 68, pos. Pesochnyi-2, St. Petersburg, 189646, Russia.
authors.forename: V N
authors.initials: VN
authors.lastname: Anisimov
mesh_terms: D000375:Aging / Q000378:metabolism*; D000704:Analysis of Variance; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D015153:Blotting, Western; D053148:Caspase 3 / Q000378:metabolism; D002470:Cell Survival / Q000502:physiology; D005260:Female; D015870:Gene Expression / Q000502:physiology; D007031:Hypothalamus / Q000378:metabolism*; D020287:In Situ Nick-End Labeling; D008822:Mice, Transgenic; D009474:Neurons / Q000378:metabolism*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics / Q000378:metabolism*; D050791:STAT Transcription Factors / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D053148:Caspase 3; D018719:Erb-b2 Receptor Tyrosine Kinases; D050791:STAT Transcription Factors; D016159:Tumor Suppressor Protein p53; C524056:Erbb2 protein, mouse; C505409:Casp3 protein, mouse