title: Mitochondrial long noncoding RNAs as blood based biomarkers for cardiac remodeling in patients with hypertrophic cardiomyopathy.
abstract: Hypertrophic cardiomyopathy (HCM) is a hereditary heart disease with a high risk for sudden cardiac death in young people. As a subtype, hypertrophic obstructive cardiomyopathy (HOCM) additionally has a left ventricular outflow gradient, showing stronger symptoms and requires a different treatment compared with hypertrophic nonobstructive cardiomyopathy (HNCM). In this study our aim was to investigate the regulation of mitochondrial and cardiac remodeling associated long noncoding RNAs (lncRNAs) in blood of patients affected with HOCM and HNCM. We included 28 HNCM, 57 HOCM, and 26 control inviduals. Already known mitochondrial and cardiac remodeling associated lncRNAs uc004cos.4, uc004coz.1, uc004cov.4, uc011mfi.2, uc022bqw.1, uc022bqs.1, and uc022bqu.1 were amplified in serum of these patients and correlated with clinical parameters. Long noncoding RNAs uc004cov.4 and uc022bqu.1 were significantly increased in patients with HOCM but not in patients with HNCM. With the use of receiver operator characteristic (ROC) curve analysis, lncRNAs uc004cov.4 and uc022bqu.1 were able to identify HOCM patients. In our study we evidenced that the specific mitochondrial long noncoding RNAs uc004cov.4 and uc022bqu.1 were upregulated in patients with HOCM and they were also able to identify HOCM and could be developed as useful clinical biomarkers in the future.
authors.affiliation: Institute of Molecular and Translational Therapeutic Strategies (IMTTS), IFB-Tx, Hannover Medical School, Hannover, Germany;
authors.forename: Janina
authors.initials: J
authors.lastname: Kitow
authors.affiliation: Institute of Molecular and Translational Therapeutic Strategies (IMTTS), IFB-Tx, Hannover Medical School, Hannover, Germany;
authors.forename: Anselm A
authors.initials: AA
authors.lastname: Derda
authors.affiliation: Institute of Molecular and Translational Therapeutic Strategies (IMTTS), IFB-Tx, Hannover Medical School, Hannover, Germany;
authors.forename: Julia
authors.initials: J
authors.lastname: Beermann
authors.affiliation: Institute of Molecular and Translational Therapeutic Strategies (IMTTS), IFB-Tx, Hannover Medical School, Hannover, Germany;
authors.forename: Regalla
authors.initials: R
authors.lastname: Kumarswarmy
authors.affiliation: Institute of Molecular and Translational Therapeutic Strategies (IMTTS), IFB-Tx, Hannover Medical School, Hannover, Germany;
authors.forename: Angelika
authors.initials: A
authors.lastname: Pfanne
authors.affiliation: Institute of Molecular and Translational Therapeutic Strategies (IMTTS), IFB-Tx, Hannover Medical School, Hannover, Germany;
authors.forename: Jasmin
authors.initials: J
authors.lastname: Fendrich
authors.affiliation: Institute of Molecular and Translational Therapeutic Strategies (IMTTS), IFB-Tx, Hannover Medical School, Hannover, Germany;
authors.forename: Johan M
authors.initials: JM
authors.lastname: Lorenzen
authors.affiliation: Institute of Molecular and Translational Therapeutic Strategies (IMTTS), IFB-Tx, Hannover Medical School, Hannover, Germany;
authors.forename: Ke
authors.initials: K
authors.lastname: Xiao
authors.affiliation: Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany; and.
authors.forename: Udo
authors.initials: U
authors.lastname: Bavendiek
authors.affiliation: Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany; and.
authors.forename: Johann
authors.initials: J
authors.lastname: Bauersachs
authors.affiliation: Institute of Molecular and Translational Therapeutic Strategies (IMTTS), IFB-Tx, Hannover Medical School, Hannover, Germany; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany; and National Heart and Lung Institute, Imperial College, London, United Kingdom thum.thomas@mh-hannover.de.
authors.forename: Thomas
authors.initials: T
authors.lastname: Thum
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002312:Cardiomyopathy, Hypertrophic / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012313:RNA / Q000097:blood*; D062085:RNA, Long Noncoding / Q000097:blood*; D000077278:RNA, Mitochondrial; D012372:ROC Curve; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013318:Stroke Volume; D014694:Ventricular Outflow Obstruction / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology; D020257:Ventricular Remodeling
chemical_list: D015415:Biomarkers; D062085:RNA, Long Noncoding; D000077278:RNA, Mitochondrial; D012313:RNA
keywords: biomarker; cardiac remodeling; diagnosis; hypertrophic cardiomyopathy; lncRNA