title: [COMPARATIVE ANALYSIS OF REPOA (EPOKRIN) AND REPOB (RECORMON) INFLUENCE ON ERYTHROPOIESIS IN VIVO AND IN VITRO].
abstract: The study performed on erythroblastic island cultures and rats with experimental polycythemia showed that recormon and epokrin stimulated erythropoiesis in erythroblastic islands both in vitro and in vivo. In cell cultures, recormon activates the formation of erythroblastic islands de novo and de repeto 1.3 times better than epokrin (p < 0.05). Erythroid cells exbhibited same reaction to epokrin and recormon in vivo: the number of erythroblastic islands in the bone marrow increased 3.4 times (p < 0.05) and the number of reticulocytes in the blood increased 2.2 times (p < 0.05).
authors.forename: N V
authors.initials: NV
authors.lastname: Tishevskaya
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D004195:Disease Models, Animal; D004900:Erythroblasts / Q000187:drug effects* / Q000473:pathology; D004920:Erythropoiesis / Q000187:drug effects*; D004921:Erythropoietin / Q000494:pharmacology*; D005260:Female; D006397:Hematinics / Q000494:pharmacology*; D011086:Polycythemia / Q000188:drug therapy* / Q000473:pathology; D061251:Primary Cell Culture; D020033:Protein Isoforms / Q000494:pharmacology; D051381:Rats; D011994:Recombinant Proteins / Q000494:pharmacology
chemical_list: D006397:Hematinics; D020033:Protein Isoforms; D011994:Recombinant Proteins; D004921:Erythropoietin