title: Molecular signatures of neural connectivity in the olfactory cortex.
abstract: The ability to target subclasses of neurons with defined connectivity is crucial for uncovering neural circuit functions. The olfactory (piriform) cortex is thought to generate odour percepts and memories, and odour information encoded in piriform is routed to target brain areas involved in multimodal sensory integration, cognition and motor control. However, it remains unknown if piriform outputs are spatially organized, and if distinct output channels are delineated by different gene expression patterns. Here we identify genes selectively expressed in different layers of the piriform cortex. Neural tracing experiments reveal that these layer-specific piriform genes mark different subclasses of neurons, which project to distinct target areas. Interestingly, these molecular signatures of connectivity are maintained in reeler mutant mice, in which neural positioning is scrambled. These results reveal that a predictive link between a neuron's molecular identity and connectivity in this cortical circuit is determined independent of its spatial position.
authors.affiliation: Center for Interdisciplinary Research in Biology (CIRB), Collège de France, and CNRS, UMR 7241 and INSERM U1050, F-75005 Paris, France.
authors.forename: Assunta
authors.initials: A
authors.lastname: Diodato
authors.affiliation: Center for Interdisciplinary Research in Biology (CIRB), Collège de France, and CNRS, UMR 7241 and INSERM U1050, F-75005 Paris, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Ruinart de Brimont
authors.affiliation: Department of Brain and Cognitive Sciences, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: Yeong Shin
authors.initials: YS
authors.lastname: Yim
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, INSERM U959, Immunology-Immunopathology-Immunotherapy (I3), and AP-HP, Clinical Investigation Center in Biotherapy, Hôpital Pitié-Salpêtrière, F-75013 Paris, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Derian
authors.affiliation: École Normale Supérieure, Institut de Biologie de l'ENS, Plateforme Génomique, and INSERM U1024, CNRS UMR 8197, F-75005 Paris, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Perrin
authors.affiliation: École Normale Supérieure, Institut de Biologie de l'ENS, Plateforme Génomique, and INSERM U1024, CNRS UMR 8197, F-75005 Paris, France.
authors.forename: Juliette
authors.initials: J
authors.lastname: Pouch
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, INSERM U959, Immunology-Immunopathology-Immunotherapy (I3), and AP-HP, Clinical Investigation Center in Biotherapy, Hôpital Pitié-Salpêtrière, F-75013 Paris, France.
authors.forename: David
authors.initials: D
authors.lastname: Klatzmann
authors.affiliation: École Normale Supérieure, Institut de Biologie de l'ENS, and INSERM U1024, CNRS UMR 8197, F-75005 Paris, France.
authors.forename: Sonia
authors.initials: S
authors.lastname: Garel
authors.affiliation: Department of Brain and Cognitive Sciences, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: Gloria B
authors.initials: GB
authors.lastname: Choi
authors.affiliation: Center for Interdisciplinary Research in Biology (CIRB), Collège de France, and CNRS, UMR 7241 and INSERM U1050, F-75005 Paris, France.
authors.forename: Alexander
authors.identifier: 0000-0001-7956-9096
authors.initials: A
authors.lastname: Fleischmann
mesh_terms: D000679:Amygdala / Q000378:metabolism; D000818:Animals; D020869:Gene Expression Profiling; D008297:Male; D008810:Mice, Inbred C57BL; D009415:Nerve Net / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism; D009830:Olfactory Bulb / Q000378:metabolism; D066194:Olfactory Cortex / Q000378:metabolism*; D066195:Piriform Cortex / Q000378:metabolism; D017397:Prefrontal Cortex / Q000378:metabolism