title: Effects of renal denervation on heart failure biomarkers and blood pressure in patients with resistant hypertension.
abstract: OBJECTIVE
  This multicenter study investigated the effect of renal denervation therapy (RDN) on the heart failure related biomarkers NT-proBNP, ST-2, galectin-3 and hs-TnI.
  
  
  METHODS
  We included 157 patients with resistant hypertension undergoing RDN. Blood sampling was performed before and 6 months after RDN.
  
  
  RESULTS
  Six months after RDN systolic blood pressure (BP) was reduced by 24 mmHg. Biomarker concentrations were not changed after RDN, except a small increase of hs-TnI by 0.3 pg/ml. In individuals with high baseline BP, we observed a BP reduction of 45 mmHg and a decrease of hs-TnI concentrations by 1.2 pg/ml.
  
  
  CONCLUSIONS
  In this multicenter analysis RDN did significantly reduce systolic BP. However, NT-proBNP, ST-2, galectin-3 and hs-TnI did not correspond to BP reduction 6 months after RDN.
authors.affiliation: Klinik für Allgemeine und Interventionelle Kardiologie, Universitäres Herzzentrum Hamburg, Hamburg, Germany.|Deutsches Zentrum für Herz-Kreislaufforschung e.V. (DZHK), Partner site Hamburg, Lübeck, Kiel, Hamburg, Germany.
authors.forename: Johannes Tobias
authors.initials: JT
authors.lastname: Neumann
authors.affiliation: Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universität des Saarlandes, Homburg/Saar, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Ewen
authors.affiliation: Klinik für Innere Medizin II, Kardiologie, Universität Lübeck, Lübeck, Germany.
authors.forename: Kai
authors.initials: K
authors.lastname: Mortensen
authors.affiliation: Klinik für Innere Medizin I, Kardiologie/Angiologie, Universität Giessen, Giessen, Germany.
authors.forename: Holger
authors.initials: H
authors.lastname: Nef
authors.affiliation: Klinik für Allgemeine und Interventionelle Kardiologie, Universitäres Herzzentrum Hamburg, Hamburg, Germany.|Deutsches Zentrum für Herz-Kreislaufforschung e.V. (DZHK), Partner site Hamburg, Lübeck, Kiel, Hamburg, Germany.
authors.forename: Tanja
authors.initials: T
authors.lastname: Zeller
authors.affiliation: Klinik für Allgemeine und Interventionelle Kardiologie, Universitäres Herzzentrum Hamburg, Hamburg, Germany.
authors.forename: Francisco
authors.initials: F
authors.lastname: Ojeda
authors.affiliation: Klinik für Allgemeine und Interventionelle Kardiologie, Universitäres Herzzentrum Hamburg, Hamburg, Germany.
authors.forename: Karsten
authors.initials: K
authors.lastname: Sydow
authors.affiliation: Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universität des Saarlandes, Homburg/Saar, Germany.
authors.forename: Felix
authors.initials: F
authors.lastname: Mahfoud
authors.affiliation: Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universität des Saarlandes, Homburg/Saar, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Böhm
authors.affiliation: Klinik für Innere Medizin I, Kardiologie/Angiologie, Universität Giessen, Giessen, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Hamm
authors.affiliation: Klinik für Innere Medizin I, Kardiologie/Angiologie, Universität Giessen, Giessen, Germany.
authors.forename: Oliver
authors.initials: O
authors.lastname: Dörr
authors.affiliation: Klinik für Allgemeine und Interventionelle Kardiologie, Universitäres Herzzentrum Hamburg, Hamburg, Germany.|Deutsches Zentrum für Herz-Kreislaufforschung e.V. (DZHK), Partner site Hamburg, Lübeck, Kiel, Hamburg, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Blankenberg
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood*; D001794:Blood Pressure / Q000502:physiology*; D004452:Echocardiography; D005260:Female; D037502:Galectin 3 / Q000097:blood; D006333:Heart Failure / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D006973:Hypertension / Q000150:complications*; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging; D000072179:Interleukin-1 Receptor-Like 1 Protein / Q000097:blood; D007668:Kidney / Q000294:innervation* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D063177:Pulse Wave Analysis; D019210:Troponin I / Q000097:blood
chemical_list: D015415:Biomarkers; D037502:Galectin 3; C079241:IL1RL1 protein, human; D000072179:Interleukin-1 Receptor-Like 1 Protein; D010446:Peptide Fragments; D019210:Troponin I; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: NT-proBNP; biomarker; hypertension; renal denervation; responder; troponin I