title: COX-2 rs689466, rs5275, and rs20417 polymorphisms and risk of head and neck squamous cell carcinoma: a meta-analysis of adjusted and unadjusted data.
abstract: Numerous case-control studies have been performed to investigate the association between three cyclooxygenase-2 (COX-2) polymorphisms (rs20417 (-765G > C), rs689466 (-1195G > A), and rs5275 (8473 T > C)) and the risk of head and neck squamous cell carcinoma (HNSCC). However, the results were inconsistent. Therefore, we conducted this meta-analysis to investigate the association.
  
  
  
  We searched in PubMed, Embase, and Web of Science up to January 20, 2015 (last updated on May 12, 2016). Two independent reviewers extracted the data. Odds ratios (ORs) with their 95 % confidence intervals (CIs) were used to assess the association. All statistical analyses were performed using the Review Manager (RevMan) 5.2 software.
  
  
  
  Finally 8 case-control studies were included in this meta-analysis. For unadjusted data, an association with increased risk was observed in three genetic models in COX-2 rs689466 polymorphism; however, COX-2 rs5275 and rs20417 polymorphisms were not related to HNSCC risk in this study. The pooled results from adjusted data all revealed non-significant association between these three polymorphisms and risk of HNSCC. We also found a similar result in the subgroup analyses, based on both unadjusted data and adjusted data.
  
  
  
  Current results suggest that COX-2 rs689466, rs5275, and rs20417 polymorphisms are not associated with HNSCC. Further large and well-designed studies are necessary to validate this association.
authors.affiliation: Department of Stomatology, Taihe Hospital, Institute of Oral and Maxillofacial Surgery, Hubei University of Medicine, Shiyan, 442000, China.
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Leng
authors.affiliation: Department of Stomatology, Daping Hospital & Research Institute of Surgery, Third Military Medical University, Chongqing, 400042, China.
authors.forename: Xiu-Jie
authors.initials: XJ
authors.lastname: Wen
authors.affiliation: Chinese Cochrane Center, Chinese Evidence-Based Medicine Center, Western China Hospital, West China Hospital, Sichuan University, Chengdu, 610041, China.
authors.forename: Joey S W
authors.initials: JSW
authors.lastname: Kwong
authors.affiliation: Department of Stomatology, Zhuhai People's Hospital, Zhuhai Hospital Affiliated with Jinan University, Zhuhai, 519000, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.affiliation: Department of Stomatology, Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan, 430071, China.
authors.forename: Jian-Gang
authors.initials: JG
authors.lastname: Chen
authors.affiliation: Department of Stomatology, Taihe Hospital, Institute of Oral and Maxillofacial Surgery, Hubei University of Medicine, Shiyan, 442000, China. zengxiantao1128@163.com.|Department of Stomatology, Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan, 430071, China. zengxiantao1128@163.com.
authors.forename: Xian-Tao
authors.initials: XT
authors.lastname: Zeng
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D051546:Cyclooxygenase 2 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006258:Head and Neck Neoplasms / Q000235:genetics*; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D000077195:Squamous Cell Carcinoma of Head and Neck
chemical_list: D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human
keywords: COX-2 rs20417; COX-2 rs5275; COX-2 rs689466; Head and neck squamous cell carcinoma; Meta-analysis; Polymorphism