title: Vitamin E Status and Neurodegenerative Disease.
abstract: Vitamin E (alpha-and gamma-tocopherol) may slow the progression of a number of major degenerative diseases of the nervous system that appear to be significantly worsened by oxidative stress. The effects of vitamin E on excitoxicity in cultured neurones is considered, together with ataxia due to vitamin E deficiency (AVED) arising from abetalipoproteinaemia, cholestatic liver disease, cystic fibrosis, short bowel syndrome, total parenteral nutrition, diabetic peripheral neuropathy and familial isolated vitamin E (FIVE) deficiency. Selenium deficiency in Keshan disease is also described in relation to the cardiomyopathy seen in Friedreich's ataxia. Evidence for any beneficial effects of vitamin E upon the course of Friedreich's ataxia, tardive dyskinesia, amyotrophic lateral sclerosis (motor neurone disease), Parkinson's disease, Alzheimer's disease, and Huntington's disease is examined. The application of vitamin E derivatives as protective agents in posttraumatic injury to the nervous system (stroke, head and spinal cord injury and haemorrhage) is discussed.
authors.affiliation: a John Tabor Laboratories, Department of Biological and Chemical Sciences , University of Essex , Wivenhoe Park, Colchester , Essex CO4 3SQ , UK.
authors.forename: M J
authors.initials: MJ
authors.lastname: Fryer
keywords: Antioxidant; Neurodegeneration; Vitamin E; α-Tocopherol; γ-Tocopherol