title: The High Radiosensitizing Efficiency of a Trace of Gadolinium-Based Nanoparticles in Tumors.
abstract: We recently developed the synthesis of ultrasmall gadolinium-based nanoparticles (GBN), (hydrodynamic diameter <5 nm) characterized by a safe behavior after intravenous injection (renal clearance, preferential accumulation in tumors). Owing to the presence of gadolinium ions, GBN can be used as contrast agents for magnetic resonance imaging (MRI) and as radiosensitizers. The attempt to determine the most opportune delay between the intravenous injection of GBN and the irradiation showed that a very low content of radiosensitizing nanoparticles in the tumor area is sufficient (0.1 μg/g of particles, i.e. 15 ppb of gadolinium) for an important increase of the therapeutic effect of irradiation. Such a promising and unexpected result is assigned to a suited distribution of GBN within the tumor, as revealed by the X-ray fluorescence (XRF) maps.
authors.affiliation: Thérapie ciblée, Diagnostic précoce et Imagerie du cancer, INSERM/UJF U823, Institut Albert Bonniot, 38706 La Tronche Cedex, France.|Nano-H S.A.S, 2 Place de l'Europe, 38070 Saint Quentin-Fallavier, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Dufort
authors.affiliation: ID17 Biomedical Beamline and ID21 Beamline, European Synchrotron Radiation Facility, 38000 Grenoble, France.
authors.forename: Géraldine
authors.initials: G
authors.lastname: Le Duc
authors.affiliation: ID17 Biomedical Beamline and ID21 Beamline, European Synchrotron Radiation Facility, 38000 Grenoble, France.
authors.forename: Murielle
authors.initials: M
authors.lastname: Salomé
authors.affiliation: ID17 Biomedical Beamline and ID21 Beamline, European Synchrotron Radiation Facility, 38000 Grenoble, France.
authors.forename: Valerie
authors.initials: V
authors.lastname: Bentivegna
authors.affiliation: Institut Lumière Matière, UMR 5306 CNRS-UCBL, Université Claude Bernard Lyon 1, 69622 Villeurbanne Cedex, France.
authors.forename: Lucie
authors.initials: L
authors.lastname: Sancey
authors.affiliation: ID17 Biomedical Beamline and ID21 Beamline, European Synchrotron Radiation Facility, 38000 Grenoble, France.
authors.forename: Elke
authors.initials: E
authors.lastname: Bräuer-Krisch
authors.affiliation: ID17 Biomedical Beamline and ID21 Beamline, European Synchrotron Radiation Facility, 38000 Grenoble, France.
authors.forename: Herwig
authors.initials: H
authors.lastname: Requardt
authors.affiliation: Institut Lumière Matière, UMR 5306 CNRS-UCBL, Université Claude Bernard Lyon 1, 69622 Villeurbanne Cedex, France.
authors.forename: François
authors.initials: F
authors.lastname: Lux
authors.affiliation: Thérapie ciblée, Diagnostic précoce et Imagerie du cancer, INSERM/UJF U823, Institut Albert Bonniot, 38706 La Tronche Cedex, France.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Coll
authors.affiliation: Matériaux Ingénierie et Science, UMR 5510 CNRS-INSA, INSA de Lyon, 69621 Villeurbanne Cedex, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Perriat
authors.affiliation: Institut UTINAM, UMR 6213 CNRS-UFC, Université de Franche-Comté, 25030 Besançon Cedex, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Roux
authors.affiliation: Institut Lumière Matière, UMR 5306 CNRS-UCBL, Université Claude Bernard Lyon 1, 69622 Villeurbanne Cedex, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Tillement
mesh_terms: D000818:Animals; D002460:Cell Line; D003287:Contrast Media / Q000008:administration & dosage; D005682:Gadolinium / Q000008:administration & dosage*; D018316:Gliosarcoma / Q000532:radiotherapy*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D053758:Nanoparticles / Q000008:administration & dosage*; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage*; D051381:Rats; D011916:Rats, Inbred F344; D014965:X-Rays
chemical_list: D003287:Contrast Media; D011838:Radiation-Sensitizing Agents; D005682:Gadolinium