title: Prevalence and Prognostic Significance of Right Ventricular Systolic Dysfunction in Patients Undergoing Transcatheter Aortic Valve Implantation.
abstract: Cardiovascular magnetic resonance (CMR) can provide important structural information in patients undergoing transcatheter aortic valve implantation. Although CMR is considered the standard of reference for measuring ventricular volumes and mass, the relationship between CMR findings of right ventricular (RV) function and outcomes after transcatheter aortic valve implantation has not previously been reported.
  
  
  
  A total of 190 patients underwent 1.5 Tesla CMR before transcatheter aortic valve implantation. Steady-state free precession sequences were used for aortic valve planimetry and to assess ventricular volumes and mass. Semiautomated image analysis was performed by 2 specialist reviewers blinded to patient treatment. Patient follow-up was obtained from the Office of National Statistics mortality database. The median age was 81.0 (interquartile range, 74.9-85.5) years; 50.0% were women. Impaired RV function (RV ejection fraction ≤50%) was present in 45 (23.7%) patients. Patients with RV dysfunction had poorer left ventricular ejection fractions (42% versus 69%), higher indexed left ventricular end-systolic volumes (96 versus 40 mL), and greater indexed left ventricular mass (101 versus 85 g/m(2); P<0.01 for all) than those with normal RV function. Median follow-up was 850 days; 21 of 45 (46.7%) patients with RV dysfunction died, compared with 43 of 145 (29.7%) patients with normal RV function (P=0.035). After adjustment for significant baseline variables, both RV ejection fraction ≤50% (hazard ratio, 2.12; P=0.017) and indexed aortic valve area (hazard ratio, 4.16; P=0.025) were independently associated with survival.
  
  
  
  RV function, measured on preprocedural CMR, is an independent predictor of mortality after transcatheter aortic valve implantation. CMR assessment of RV function may be important in the risk stratification of patients undergoing transcatheter aortic valve implantation.
authors.affiliation: From the Department of Cardiology (A.C.L., R.J.J., R.K., T.M.S., P.S., M.R., A.D., C.D.M., S.W.D.), Department of Cardiovascular Magnetic Resonance (F.A., D.J.P., R.H.M.), and Department of Surgery (N.E.M.), Royal Brompton and Harefield NHS Trust, London, United Kingdom; Department of Statistics, London School of Hygiene and Tropical Medicine, University College London, United Kingdom (K.H.); and Department of Cardiovascular Medicine, Imperial College, London, United Kingdom (D.J.P., R.H.M.). dralistairlindsay@outlook.com.
authors.forename: Alistair C
authors.initials: AC
authors.lastname: Lindsay
authors.affiliation: From the Department of Cardiology (A.C.L., R.J.J., R.K., T.M.S., P.S., M.R., A.D., C.D.M., S.W.D.), Department of Cardiovascular Magnetic Resonance (F.A., D.J.P., R.H.M.), and Department of Surgery (N.E.M.), Royal Brompton and Harefield NHS Trust, London, United Kingdom; Department of Statistics, London School of Hygiene and Tropical Medicine, University College London, United Kingdom (K.H.); and Department of Cardiovascular Medicine, Imperial College, London, United Kingdom (D.J.P., R.H.M.).
authors.forename: Katie
authors.initials: K
authors.lastname: Harron
authors.affiliation: From the Department of Cardiology (A.C.L., R.J.J., R.K., T.M.S., P.S., M.R., A.D., C.D.M., S.W.D.), Department of Cardiovascular Magnetic Resonance (F.A., D.J.P., R.H.M.), and Department of Surgery (N.E.M.), Royal Brompton and Harefield NHS Trust, London, United Kingdom; Department of Statistics, London School of Hygiene and Tropical Medicine, University College London, United Kingdom (K.H.); and Department of Cardiovascular Medicine, Imperial College, London, United Kingdom (D.J.P., R.H.M.).
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Jabbour
authors.affiliation: From the Department of Cardiology (A.C.L., R.J.J., R.K., T.M.S., P.S., M.R., A.D., C.D.M., S.W.D.), Department of Cardiovascular Magnetic Resonance (F.A., D.J.P., R.H.M.), and Department of Surgery (N.E.M.), Royal Brompton and Harefield NHS Trust, London, United Kingdom; Department of Statistics, London School of Hygiene and Tropical Medicine, University College London, United Kingdom (K.H.); and Department of Cardiovascular Medicine, Imperial College, London, United Kingdom (D.J.P., R.H.M.).
authors.forename: Ritesh
authors.initials: R
authors.lastname: Kanyal
authors.affiliation: From the Department of Cardiology (A.C.L., R.J.J., R.K., T.M.S., P.S., M.R., A.D., C.D.M., S.W.D.), Department of Cardiovascular Magnetic Resonance (F.A., D.J.P., R.H.M.), and Department of Surgery (N.E.M.), Royal Brompton and Harefield NHS Trust, London, United Kingdom; Department of Statistics, London School of Hygiene and Tropical Medicine, University College London, United Kingdom (K.H.); and Department of Cardiovascular Medicine, Imperial College, London, United Kingdom (D.J.P., R.H.M.).
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Snow
authors.affiliation: From the Department of Cardiology (A.C.L., R.J.J., R.K., T.M.S., P.S., M.R., A.D., C.D.M., S.W.D.), Department of Cardiovascular Magnetic Resonance (F.A., D.J.P., R.H.M.), and Department of Surgery (N.E.M.), Royal Brompton and Harefield NHS Trust, London, United Kingdom; Department of Statistics, London School of Hygiene and Tropical Medicine, University College London, United Kingdom (K.H.); and Department of Cardiovascular Medicine, Imperial College, London, United Kingdom (D.J.P., R.H.M.).
authors.forename: Paramvir
authors.initials: P
authors.lastname: Sawhney
authors.affiliation: From the Department of Cardiology (A.C.L., R.J.J., R.K., T.M.S., P.S., M.R., A.D., C.D.M., S.W.D.), Department of Cardiovascular Magnetic Resonance (F.A., D.J.P., R.H.M.), and Department of Surgery (N.E.M.), Royal Brompton and Harefield NHS Trust, London, United Kingdom; Department of Statistics, London School of Hygiene and Tropical Medicine, University College London, United Kingdom (K.H.); and Department of Cardiovascular Medicine, Imperial College, London, United Kingdom (D.J.P., R.H.M.).
authors.forename: Francisco
authors.initials: F
authors.lastname: Alpendurada
authors.affiliation: From the Department of Cardiology (A.C.L., R.J.J., R.K., T.M.S., P.S., M.R., A.D., C.D.M., S.W.D.), Department of Cardiovascular Magnetic Resonance (F.A., D.J.P., R.H.M.), and Department of Surgery (N.E.M.), Royal Brompton and Harefield NHS Trust, London, United Kingdom; Department of Statistics, London School of Hygiene and Tropical Medicine, University College London, United Kingdom (K.H.); and Department of Cardiovascular Medicine, Imperial College, London, United Kingdom (D.J.P., R.H.M.).
authors.forename: Michael
authors.initials: M
authors.lastname: Roughton
authors.affiliation: From the Department of Cardiology (A.C.L., R.J.J., R.K., T.M.S., P.S., M.R., A.D., C.D.M., S.W.D.), Department of Cardiovascular Magnetic Resonance (F.A., D.J.P., R.H.M.), and Department of Surgery (N.E.M.), Royal Brompton and Harefield NHS Trust, London, United Kingdom; Department of Statistics, London School of Hygiene and Tropical Medicine, University College London, United Kingdom (K.H.); and Department of Cardiovascular Medicine, Imperial College, London, United Kingdom (D.J.P., R.H.M.).
authors.forename: Dudley J
authors.initials: DJ
authors.lastname: Pennell
authors.affiliation: From the Department of Cardiology (A.C.L., R.J.J., R.K., T.M.S., P.S., M.R., A.D., C.D.M., S.W.D.), Department of Cardiovascular Magnetic Resonance (F.A., D.J.P., R.H.M.), and Department of Surgery (N.E.M.), Royal Brompton and Harefield NHS Trust, London, United Kingdom; Department of Statistics, London School of Hygiene and Tropical Medicine, University College London, United Kingdom (K.H.); and Department of Cardiovascular Medicine, Imperial College, London, United Kingdom (D.J.P., R.H.M.).
authors.forename: Alison
authors.initials: A
authors.lastname: Duncan
authors.affiliation: From the Department of Cardiology (A.C.L., R.J.J., R.K., T.M.S., P.S., M.R., A.D., C.D.M., S.W.D.), Department of Cardiovascular Magnetic Resonance (F.A., D.J.P., R.H.M.), and Department of Surgery (N.E.M.), Royal Brompton and Harefield NHS Trust, London, United Kingdom; Department of Statistics, London School of Hygiene and Tropical Medicine, University College London, United Kingdom (K.H.); and Department of Cardiovascular Medicine, Imperial College, London, United Kingdom (D.J.P., R.H.M.).
authors.forename: Carlo
authors.initials: C
authors.lastname: Di Mario
authors.affiliation: From the Department of Cardiology (A.C.L., R.J.J., R.K., T.M.S., P.S., M.R., A.D., C.D.M., S.W.D.), Department of Cardiovascular Magnetic Resonance (F.A., D.J.P., R.H.M.), and Department of Surgery (N.E.M.), Royal Brompton and Harefield NHS Trust, London, United Kingdom; Department of Statistics, London School of Hygiene and Tropical Medicine, University College London, United Kingdom (K.H.); and Department of Cardiovascular Medicine, Imperial College, London, United Kingdom (D.J.P., R.H.M.).
authors.forename: Simon W
authors.initials: SW
authors.lastname: Davies
authors.affiliation: From the Department of Cardiology (A.C.L., R.J.J., R.K., T.M.S., P.S., M.R., A.D., C.D.M., S.W.D.), Department of Cardiovascular Magnetic Resonance (F.A., D.J.P., R.H.M.), and Department of Surgery (N.E.M.), Royal Brompton and Harefield NHS Trust, London, United Kingdom; Department of Statistics, London School of Hygiene and Tropical Medicine, University College London, United Kingdom (K.H.); and Department of Cardiovascular Medicine, Imperial College, London, United Kingdom (D.J.P., R.H.M.).
authors.forename: Raad H
authors.initials: RH
authors.lastname: Mohiaddin
authors.affiliation: From the Department of Cardiology (A.C.L., R.J.J., R.K., T.M.S., P.S., M.R., A.D., C.D.M., S.W.D.), Department of Cardiovascular Magnetic Resonance (F.A., D.J.P., R.H.M.), and Department of Surgery (N.E.M.), Royal Brompton and Harefield NHS Trust, London, United Kingdom; Department of Statistics, London School of Hygiene and Tropical Medicine, University College London, United Kingdom (K.H.); and Department of Cardiovascular Medicine, Imperial College, London, United Kingdom (D.J.P., R.H.M.).
authors.forename: Neil E
authors.initials: NE
authors.lastname: Moat
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001021:Aortic Valve / Q000000981:diagnostic imaging / Q000601:surgery*; D001024:Aortic Valve Stenosis / Q000000981:diagnostic imaging / Q000401:mortality / Q000601:surgery*; D004452:Echocardiography; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008131:London / Q000453:epidemiology; D008279:Magnetic Resonance Imaging; D008297:Male; D011237:Predictive Value of Tests; D015995:Prevalence; D016016:Proportional Hazards Models; D012307:Risk Factors; D012720:Severity of Illness Index; D013318:Stroke Volume; D013599:Systole; D013997:Time Factors; D065467:Transcatheter Aortic Valve Replacement / Q000009:adverse effects / Q000401:mortality; D016896:Treatment Outcome; D018497:Ventricular Dysfunction, Right / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000401:mortality / Q000503:physiopathology; D016278:Ventricular Function, Right
keywords: magnetic resonance imaging; prognosis; transcatheter aortic valve replacement; ventricular ejection fraction; ventricular function, right