title: Self-healing supramolecular bioelastomers with shape memory property as a multifunctional platform for biomedical applications via modular assembly.
abstract: Mimicking native functional dynamics for traditional biomaterials such as thermoset elastomers is limited due to their lack of responsiveness to biological stimuli and difficulties to incorporate biofunctionalities. Furthermore, the mechanical fracture of traditional thermoset elastomers caused by irreversible covalent bond rupture would lead to their permanent loss of properties. To overcome these challenges, degradable self-healed supramolecular bioelastomers are designed by an elastic poly(glycerol sebacate) (PGS) backbone and multiple hydrogen-bonding ureido-pyrimidinone (UPy) grafts. These supramolecular elastic polymers exhibit efficient self-healing, rapid shape-memory abilities and highly tunable mechanical properties due to the dynamic supramolecular interactions, and perform a good biocompatibility in vitro and a mild host response in vivo. By combining modular approaches, these supramolecular bioelastomers have been further assembled into a multifunctional platform to expand their applications in different biomedical fields. These include a complex 3D scaffold with shape-memory capacity and anisotropic mechanical properties, a controllable drug delivery model via a layer-by-layer technique, a surface antibacterial composite by physical modification, and a spatial oriented cell co-culture system via incorporating different cell-laden self-healing films, demonstrating their potential as building blocks in a wide range of biomedical applications where dynamic properties and biological functions are desired.
authors.affiliation: Frontier Institute of Science and Technology, and State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an, 710049, China.
authors.forename: Yaobin
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Frontier Institute of Science and Technology, and State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an, 710049, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Wang
authors.affiliation: Frontier Institute of Science and Technology, and State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an, 710049, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Frontier Institute of Science and Technology, and State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an, 710049, China.
authors.forename: Sen
authors.initials: S
authors.lastname: Hou
authors.affiliation: Frontier Institute of Science and Technology, and State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an, 710049, China. Electronic address: baoling@mail.xjtu.edu.cn.
authors.forename: Baolin
authors.initials: B
authors.lastname: Guo
authors.affiliation: Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA; Macromolecular Science and Engineering Center, University of Michigan, Ann Arbor, MI 48109, USA; Department of Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: mapx@umich.edu.
authors.forename: Peter X
authors.initials: PX
authors.lastname: Ma
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D003651:Decanoates / Q000737:chemistry*; D055119:Elastic Modulus; D020724:Elastomers / Q000737:chemistry*; D005990:Glycerol / Q000031:analogs & derivatives* / Q000737:chemistry; D006860:Hydrogen Bonding; D046911:Macromolecular Substances / Q000737:chemistry; D008968:Molecular Conformation; D053769:Nanocapsules / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011744:Pyrimidinones / Q000737:chemistry*; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; D003651:Decanoates; D020724:Elastomers; D046911:Macromolecular Substances; D053769:Nanocapsules; D011108:Polymers; D011744:Pyrimidinones; C469892:poly(glycerol-sebacate); D005990:Glycerol
keywords: Modular approach; Multiple biomedical applications; Self-healing; Shape-memory; Supramolecular bioelastomer