title: Ibrutinib penetrates the blood brain barrier and shows efficacy in the therapy of Bing Neel syndrome.
authors.affiliation: Division of Hematology, Northwell Health Cancer Institute, Hofstra Northwell School of Medicine, Lake Success, NY, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Mason
authors.affiliation: Division of Hematology, Northwell Health Cancer Institute, Hofstra Northwell School of Medicine, Lake Success, NY, USA.
authors.forename: Steven
authors.initials: S
authors.lastname: Savona
authors.affiliation: Hofstra Northwell School of Medicine, Lake Success, NY, USA.|Department of Radiology, Hofstra Northwell School of Medicine, Lake Success, NY, USA.
authors.forename: Josephine N
authors.initials: JN
authors.lastname: Rini
authors.affiliation: Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
authors.forename: Jorge J
authors.initials: JJ
authors.lastname: Castillo
authors.affiliation: Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
authors.forename: Lian
authors.initials: L
authors.lastname: Xu
authors.affiliation: Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
authors.forename: Zachary R
authors.initials: ZR
authors.lastname: Hunter
authors.affiliation: Bing Center for Waldenstrom's Macroglobulinemia, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
authors.forename: Steven P
authors.initials: SP
authors.lastname: Treon
authors.affiliation: Division of Hematology, Northwell Health Cancer Institute, Hofstra Northwell School of Medicine, Lake Success, NY, USA.
authors.forename: Steven L
authors.initials: SL
authors.lastname: Allen
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D015415:Biomarkers; D001812:Blood-Brain Barrier / Q000378:metabolism*; D016543:Central Nervous System Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000556:secondary*; D006801:Humans; D016130:Immunophenotyping; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010880:Piperidines; D000072078:Positron Emission Tomography Computed Tomography; D047428:Protein Kinase Inhibitors / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011720:Pyrazoles / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011743:Pyrimidines / Q000008:administration & dosage / Q000493:pharmacokinetics*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D008258:Waldenstrom Macroglobulinemia / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D015415:Biomarkers; D010880:Piperidines; D047428:Protein Kinase Inhibitors; D011720:Pyrazoles; D011743:Pyrimidines; C551803:ibrutinib; D000225:Adenine
keywords: Bing Neel syndrome; CXCR4; MYD88; Waldenström macroglobulinemia; ibrutinib