title: Dietary folate intake and modification of the association of urinary bisphenol A concentrations with in vitro fertilization outcomes among women from a fertility clinic.
abstract: Experimental data in rodents suggest that the effects of bisphenol A (BPA) on oocyte development may be modified by dietary methyl donors. Whether the same interaction exists in humans is unknown. We evaluated whether intake of methyl donors modified the associations between urinary BPA concentrations and treatment outcomes among 178 women who underwent 248 IVF cycles at a fertility center in Boston between 2007 and 2012. Participants completed a validated food frequency questionnaire and provided up to two urine samples per treatment cycle. High urinary BPA concentrations were associated with a 66% lower probability of implantation (p=0.007) among women who consumed <400μg/day of food folate, but not among women consuming ≥400μg/day (21% higher probability of implantation, p=0.18) (p,interaction=0.04). A similar pattern was observed for probability of clinical pregnancy (p,interaction=0.07) and live birth (p,interaction=0.16). These results are consistent with previous animal data but further evaluation in other human populations is needed.
authors.affiliation: Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, United States. Electronic address: lminguez@hsph.harvard.edu.
authors.forename: Lidia
authors.initials: L
authors.lastname: Mínguez-Alarcón
authors.affiliation: Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, United States.
authors.forename: Audrey J
authors.initials: AJ
authors.lastname: Gaskins
authors.affiliation: Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, United States.
authors.forename: Yu-Han
authors.initials: YH
authors.lastname: Chiu
authors.affiliation: Vincent Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, Boston, United States.
authors.forename: Irene
authors.initials: I
authors.lastname: Souter
authors.affiliation: Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, United States; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, United States.
authors.forename: Paige L
authors.initials: PL
authors.lastname: Williams
authors.affiliation: National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, United States.
authors.forename: Antonia M
authors.initials: AM
authors.lastname: Calafat
authors.affiliation: Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, United States; Vincent Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, Boston, United States.
authors.forename: Russ
authors.initials: R
authors.lastname: Hauser
authors.affiliation: Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, United States; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.
authors.forename: Jorge E
authors.initials: JE
authors.lastname: Chavarro
mesh_terms: D000328:Adult; D001559:Benzhydryl Compounds / Q000652:urine*; D004032:Diet; D010064:Embryo Implantation; D004785:Environmental Pollutants / Q000652:urine*; D005260:Female; D005307:Fertilization in Vitro; D005492:Folic Acid / Q000008:administration & dosage*; D006801:Humans; D050498:Live Birth; D010636:Phenols / Q000652:urine*; D011247:Pregnancy; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004785:Environmental Pollutants; D005492:Folic Acid; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Bisphenol A; Folate; In vitro fertilization; Methyl donors