title: The role of prophylactic use of low dose aspirin and calheparin in patients with unexplained recurrent abortion.
abstract: OBJECTIVE
  To study the effect of prophylactic use of low dose aspirin and heparin on patients with recurrent unexplained pregnancy loss.
  
  
  METHODS
  Prospective case control study conducted on 180 pregnant women randomized into two equal groups. Group 1 received low-dose aspirin 75 mg and heparin 5000 IU subcutaneous every 12 h. Group 2 received no treatment.
  
  
  RESULTS
  There was a statistically significant difference between the two study groups regarding number of patients who completed their first trimester (66 versus 39) (p values 0.018). The outcome regarding completion of first trimester was not related to age, BMI or number of previous abortions in both the study groups. Complications of the use of aspirin calheparin occurred in 60% of the patients. The most common complication was bruising at injection site occurring in 60% of the patients followed by bleeding gums (14.4%), gastrointestinal troubles (12.2%), epistaxis (10%) and transient thrombocytopenia in only 2.22% of the patients (Table 4).
  
  
  CONCLUSIONS
  The use of prophylactic dose of calheparin and aspirin is associated with increased chance of passing 1st trimester safely regardless the age, body mass index or number of abortion in women with unexplained recurrent spontaneous abortion.
authors.affiliation: a Obstetrics and Gynecology Department, Kasr AlAini Hospital Cairo University , Cairo , Egypt and.
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Maged
authors.affiliation: a Obstetrics and Gynecology Department, Kasr AlAini Hospital Cairo University , Cairo , Egypt and.
authors.forename: Aly
authors.initials: A
authors.lastname: Abdelhafiz
authors.affiliation: a Obstetrics and Gynecology Department, Kasr AlAini Hospital Cairo University , Cairo , Egypt and.
authors.forename: Walaa Ai
authors.initials: WA
authors.lastname: Mostafa
authors.affiliation: a Obstetrics and Gynecology Department, Kasr AlAini Hospital Cairo University , Cairo , Egypt and.
authors.forename: Noura
authors.initials: N
authors.lastname: El-Nassery
authors.affiliation: a Obstetrics and Gynecology Department, Kasr AlAini Hospital Cairo University , Cairo , Egypt and.
authors.forename: Mona
authors.initials: M
authors.lastname: Fouad
authors.affiliation: a Obstetrics and Gynecology Department, Kasr AlAini Hospital Cairo University , Cairo , Egypt and.
authors.forename: Emad
authors.initials: E
authors.lastname: Salah
authors.affiliation: b Obstetrics and Gynecology Department, Beni Suef University , Beni-Suef , Egypt.
authors.forename: Amal
authors.initials: A
authors.lastname: Kotb
mesh_terms: D000026:Abortion, Habitual / Q000517:prevention & control*; D000328:Adult; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D016022:Case-Control Studies; D004359:Drug Therapy, Combination; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D006493:Heparin / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000187:drug effects*; D011446:Prospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D005343:Fibrinolytic Agents; D006493:Heparin; D001241:Aspirin
keywords: Aspirin; Calheparin; unexplained recurrent abortion