title: Non-tuberculous Mycobacteriosis with T-cell Lymphoma in a Red Panda (Ailurus fulgens).
abstract: A 9-year-old male red panda (Ailurus fulgens) became emaciated and died. Necropsy examination revealed systemic lymphadenomegaly. The liver, lungs and left kidney contained multifocal yellow nodules. Microscopical examination revealed granulomatous inflammation in the liver, lungs, kidney, spleen and lymph nodes, with numerous acid-fast bacilli. Sequencing of genetic material isolated from the tissues classified the pathogen as Mycobacterium gastri. Lymphoma was found in the liver, lungs, kidney and lymph nodes. The neoplastic cells were strongly labelled for expression of CD3, Ki67 and proliferating cell nuclear antigen by immunohistochemistry. This is the first report of M. gastri infection with T-cell lymphoma in a red panda.
authors.affiliation: Department of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Fuke
authors.affiliation: Department of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan. Electronic address: t-hirai@cc.miyazaki-u.ac.jp.
authors.forename: T
authors.initials: T
authors.lastname: Hirai
authors.affiliation: Department of Veterinary Microbiology, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Makimura
authors.affiliation: Department of Veterinary Microbiology, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Goto
authors.affiliation: Department of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.
authors.forename: W A
authors.initials: WA
authors.lastname: Habibi
authors.affiliation: Department of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ito
authors.affiliation: Department of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan; Department of Veterinary Public Health, Faculty of Veterinary Medicine, Vietnam National University of Agriculture, Hanoi, Vietnam.
authors.forename: N T
authors.initials: NT
authors.lastname: Trang
authors.affiliation: Miyazaki City Phoenix Zoo, Miyazaki, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Koshino
authors.affiliation: Miyazaki City Phoenix Zoo, Miyazaki, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Takeda
authors.affiliation: Department of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Yamaguchi
mesh_terms: D053822:Ailuridae / Q000382:microbiology; D000818:Animals; D000836:Animals, Zoo / Q000382:microbiology; D016399:Lymphoma, T-Cell / Q000662:veterinary*; D008297:Male; D009161:Mycobacterium; D009164:Mycobacterium Infections / Q000662:veterinary*
keywords: Mycobacterium gastri; T-cell lymphoma; non-tuberculous mycobacteriosis; red panda