title: Prognostic significance of lymphocyte-to-monocyte ratio in diffuse large B-cell lymphoma: a systematic review and meta-analysis.
abstract: Published evidence on the prognostic significance of lymphocyte-to-monocyte ratio (LMR) in diffuse large B-cell lymphoma (DLBCL) is controversial. We performed an updated meta-analysis from 12 reports with 5021 patients to more accurately evaluate the prognostic value of LMR in DLBCL. Herein, we confirmed that patients with low LMR had shorter overall survival and progression-free survival than those with high LMR in DLBCL. Subgroup analyses indicated that patient source, cut-off values of LMR, treatment methods, and sample size showed similar prognostic performance in DLBCL patients. No significant heterogeneity was observed for progression-free survival (PFS, P (het) = 0.192) among the enrolled studies. The meta-analysis suggests that the LMR may be a potential biomarker in the prediction of clinical outcomes for DLBCL patients.
authors.affiliation: Department of Nephrology The Affiliated Jiangyin Hospital of Southeast University Medical College Jiangsu China.
authors.forename: Wen-Kai
authors.initials: WK
authors.lastname: Xia
authors.affiliation: Department of Oncology The Affiliated Jiangyin Hospital of Southeast University Medical College Jiangsu China.
authors.forename: Qing-Feng
authors.initials: QF
authors.lastname: Lin
authors.affiliation: Department of Oncology The Affiliated Jiangyin Hospital of Southeast University Medical College Jiangsu China.
authors.forename: Dong
authors.initials: D
authors.lastname: Shen
authors.affiliation: Department of Oncology The Affiliated Jiangyin Hospital of Southeast University Medical College Jiangsu China.
authors.forename: Zhi-Li
authors.initials: ZL
authors.lastname: Liu
authors.affiliation: Department of Oncology The Affiliated Jiangyin Hospital of Southeast University Medical College Jiangsu China.
authors.forename: Jun
authors.initials: J
authors.lastname: Su
authors.affiliation: Department of Oncology The Affiliated Jiangyin Hospital of Southeast University Medical College Jiangsu China.
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Mao
keywords: diffuse large B‐cell lymphoma; lymphocyte‐to‐monocyte ratio; meta‐analysis; prognosis