title: Interleukin-27 as a Novel Biomarker for Early Cardiopulmonary Failure in Enterovirus 71-Infected Children with Central Nervous System Involvement.
abstract: Enterovirus 71 (EV71) is a major pathogen for severe hand, foot, and mouth disease (HFMD), which leads to severe neurological complications and has high morbidity and mortality. Reliable biomarker for the prediction of deterioration in EV71-infected children with central nervous system (CNS) involvement may reduce the cardiopulmonary failure and mortality. Here, we found that serum IL-27 levels were significantly higher in stage III EV71-infected HFMD patients with early cardiopulmonary failure and strong correlation with CRP levels. IL27p28 polymorphisms (rs153109, rs17855750, and rs181206) did not influence IL-27 production, and these three SNPs were not associated with EV71 infection risk and clinical stage. IL-27 can be used as an prediction indicator for early cardiopulmonary failure in EV71-infected children with CNS involvement.
authors.affiliation: Department of Sanitary Analysis, Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan 523808, China; Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan 523808, China.
authors.forename: Mingyuan
authors.initials: M
authors.lastname: Huang
authors.affiliation: Department of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.
authors.forename: Wenjing
authors.initials: W
authors.lastname: Du
authors.affiliation: Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan 523808, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.affiliation: Guangzhou Nansha Center for Disease Control and Prevention, Guangzhou 511458, China.
authors.forename: Haiyang
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan 523808, China.
authors.forename: Longbin
authors.initials: L
authors.lastname: Cao
authors.affiliation: Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan 523808, China.
authors.forename: Weiqing
authors.initials: W
authors.lastname: Yang
authors.affiliation: Guangzhou Nansha Central Hospital, Guangzhou 511458, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan 523808, China.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan 523808, China.
authors.forename: Pei
authors.initials: P
authors.lastname: Wei
authors.affiliation: Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan 523808, China.
authors.forename: Weiquan
authors.initials: W
authors.lastname: Wu
authors.affiliation: Department of Sanitary Analysis, Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan 523808, China; Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan 523808, China.
authors.forename: Zhulin
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Department of Sanitary Analysis, Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan 523808, China; Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan 523808, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Fang
authors.affiliation: Department of Sanitary Analysis, Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan 523808, China; Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan 523808, China.
authors.forename: Qiling
authors.initials: Q
authors.lastname: Lin
authors.affiliation: Department of Sanitary Analysis, Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan 523808, China; Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan 523808, China.
authors.forename: Xingwen
authors.initials: X
authors.lastname: Qin
authors.affiliation: Guangzhou Nansha Center for Disease Control and Prevention, Guangzhou 511458, China.
authors.forename: Zhizhong
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan 523808, China.
authors.forename: Keyuan
authors.initials: K
authors.lastname: Zhou
authors.affiliation: Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan 523808, China.
authors.forename: Jincheng
authors.identifier: 0000-0002-7713-5080
authors.initials: J
authors.lastname: Zeng
mesh_terms: D015415:Biomarkers / Q000097:blood; D002493:Central Nervous System Diseases / Q000150:complications* / Q000821:virology; D002675:Child, Preschool; D004770:Enterovirus / Q000235:genetics; D004769:Enterovirus Infections / Q000150:complications*; D005260:Female; D005838:Genotype; D006331:Heart Diseases / Q000150:complications* / Q000821:virology; D006801:Humans; D007223:Infant; D007378:Interleukins / Q000097:blood*; D008171:Lung Diseases / Q000150:complications* / Q000821:virology; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis
chemical_list: D015415:Biomarkers; D007378:Interleukins; C464565:MYDGF protein, human