title: Effects of Age and Acute Moderate Alcohol Administration on Electrophysiological Correlates of Working Memory Maintenance.
abstract: Previous studies suggest older adults may be differentially susceptible to the acute neurobehavioral effects of moderate alcohol intake. To our knowledge, no studies have addressed acute moderate alcohol effects on the electrophysiological correlates of working memory in younger and older social drinkers. This study characterized alcohol-related effects on frontal theta (FTP) and posterior alpha power (PAP) associated with maintenance of visual information during a working memory task.
  
  
  
  Older (55 to 70 years of age; n = 51, 29 women) and younger (25 to 35 years of age; n = 70, 39 women) community-dwelling moderate drinkers were recruited for this study. Participants were given either placebo or an active dose targeting breath alcohol concentrations (BrACs) of 0.04 or 0.065 g/dl. Following absorption, participants completed a visual working memory task assessing cue recognition following a 9-s delay. FTP and PAP were determined via Fourier transformation and subjected to 2 (age group) × 3 (dose) × 2 (repeated: working memory task condition) mixed models analysis.
  
  
  
  In addition to expected age-related reductions in PAP, a significant age group × dose interaction was detected for PAP such that 0.04 g/dl dose level was associated with greater PAP in younger adults but lower PAP in their older counterparts. PAP was lower in older versus younger adults at both active doses. Further mixed models revealed a significant negative association between PAP and working memory efficiency for older adults. No effects of age, dose, or their interaction were noted for FTP.
  
  
  
  Results bolster the small but growing body of evidence that older adults exhibit differential sensitivity to the neurobehavioral effects of moderate alcohol use. Given the theoretical role of PAP in attentional and working memory function, these findings shed light on the attentional mechanisms underlying effects of acute moderate alcohol on working memory efficiency in older adults.
authors.affiliation: Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida.|Center for Pain Research and Behavioral Health, University of Florida, Gainesville, Florida.
authors.forename: Jeff
authors.initials: J
authors.lastname: Boissoneault
authors.affiliation: Department of Psychology, University of Florida, Gainesville, Florida.
authors.forename: Ian
authors.initials: I
authors.lastname: Frazier
authors.affiliation: Department of Psychiatry, University of Florida, Gainesville, Florida.
authors.forename: Ben
authors.initials: B
authors.lastname: Lewis
authors.affiliation: Department of Psychology, University of Florida, Gainesville, Florida.|Department of Psychiatry, University of Florida, Gainesville, Florida.
authors.forename: Sara Jo
authors.initials: SJ
authors.lastname: Nixon
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000187:drug effects / Q000502:physiology*; D000428:Alcohol Drinking / Q000503:physiopathology*; D001944:Breath Tests / Q000379:methods; D003430:Cross-Sectional Studies; D004311:Double-Blind Method; D055724:Electrophysiological Phenomena / Q000187:drug effects / Q000502:physiology; D000431:Ethanol / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects / Q000502:physiology*; D008875:Middle Aged; D010775:Photic Stimulation / Q000379:methods; D011597:Psychomotor Performance / Q000187:drug effects / Q000502:physiology*
chemical_list: D000431:Ethanol
keywords: Aging; Alcohol; Alpha; Moderate Drinking; Theta; Working Memory