title: The impact of parkinson's disease on the cortical mechanisms that support auditory-motor integration for voice control.
abstract: Several studies have shown sensorimotor deficits in speech processing in individuals with idiopathic Parkinson's disease (PD). The underlying neural mechanisms, however, remain poorly understood. In the present event-related potential (ERP) study, 18 individuals with PD and 18 healthy controls were exposed to frequency-altered feedback (FAF) while producing a sustained vowel and listening to the playback of their own voice. Behavioral results revealed that individuals with PD produced significantly larger vocal compensation for pitch feedback errors than healthy controls, and exhibited a significant positive correlation between the magnitude of their vocal responses and the variability of their unaltered vocal pitch. At the cortical level, larger P2 responses were observed for individuals with PD compared with healthy controls during active vocalization due to left-lateralized enhanced activity in the superior and inferior frontal gyrus, premotor cortex, inferior parietal lobule, and superior temporal gyrus. These two groups did not differ, however, when they passively listened to the playback of their own voice. Individuals with PD also exhibited larger P2 responses during active vocalization when compared with passive listening due to enhanced activity in the inferior frontal gyrus, precental gyrus, postcentral gyrus, and middle temporal gyrus. This enhancement effect, however, was not observed for healthy controls. These findings provide neural evidence for the abnormal auditory-vocal integration for voice control in individuals with PD, which may be caused by their deficits in the detection and correction of errors in voice auditory feedback. Hum Brain Mapp 37:4248-4261, 2016. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.
authors.forename: Xiyan
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.affiliation: CAS Key Laboratory of Human-Machine Intelligence-Synergy Systems, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Yan
authors.affiliation: Psychology Department and Laurier Centre for Cognitive Neuroscience, Wilfrid Laurier University, N2L 3C5, Waterloo, Ontario, Canada.
authors.forename: Jeffery A
authors.initials: JA
authors.lastname: Jones
authors.affiliation: Department of Communication Disorders and Sciences, RUSH University Medical Center, 1653 West Congress Parkway, 203 SENN, Chicago, Illinois, 60612.
authors.forename: Emily Q
authors.initials: EQ
authors.lastname: Wang
authors.affiliation: Department of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Biomedical Engineering School of Engineering, Sun Yat-Sen University, Guangzhou, China, 510006.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Guo
authors.affiliation: Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.
authors.forename: Weifeng
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Liu
authors.affiliation: Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.|Guangdong Provincial Key Laboratory of Brain Function and Disease Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China, 510080.
authors.forename: Hanjun
authors.initials: H
authors.lastname: Liu
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D000978:Antiparkinson Agents / Q000627:therapeutic use; D002540:Cerebral Cortex / Q000503:physiopathology*; D004569:Electroencephalography; D005071:Evoked Potentials; D056228:Feedback, Sensory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology*; D010898:Pitch Perception / Q000502:physiology*; D012815:Signal Processing, Computer-Assisted; D013060:Speech / Q000502:physiology; D013067:Speech Perception / Q000502:physiology; D014831:Voice / Q000502:physiology*
chemical_list: D000978:Antiparkinson Agents
keywords: Parkinson's disease; auditory feedback; auditory-vocal integration; event-related potentials; sLORETA