title: [Necrotizing funisitis : Histopathological indicator of occult congenital syphilis].
abstract: Congenital syphilis is a rare disease in central Europe. Placental changes may be non-specific but a typical finding is necrotizing funisitis of the umbilical cord. In a case report we describe how the histopathological incidental finding of B lymphocyte-rich, necrotizing funisitis led to the diagnosis of a previously unknown Treponema pallidum infection in parents and their newborn child. The pathological suspicion of congenital syphilis, although rare, has implications for the clinical management (serological evaluation of parents and child as well as the social environment, evaluation of viral coinfection and treatment decision) and is a notifiable disease.
authors.affiliation: Institut für Pathologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland. hussein.kais@mh-hannover.de.
authors.forename: K
authors.initials: K
authors.lastname: Hussein
authors.affiliation: Klinik für Pädiatrische Pneumologie, Allergologie und Neonatologie, Medizinische Hochschule Hannover, Hannover, Deutschland.
authors.forename: C
authors.initials: C
authors.lastname: Peter
authors.affiliation: Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Medizinische Hochschule Hannover, Hannover, Deutschland.
authors.forename: L
authors.initials: L
authors.lastname: Sedlacek
authors.affiliation: Klinik für Frauenheilkunde, Geburtshilfe und Reproduktionsmedizin, Medizinische Hochschule Hannover, Hannover, Deutschland.
authors.forename: C von
authors.initials: CV
authors.lastname: Kaisenberg
authors.affiliation: Institut für Pathologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.
authors.forename: H H
authors.initials: HH
authors.lastname: Kreipe
mesh_terms: D001402:B-Lymphocytes / Q000473:pathology; D002585:Cesarean Section; D002821:Chorioamnionitis / Q000473:pathology*; D057210:Delayed Diagnosis; D005260:Female; D005317:Fetal Growth Retardation / Q000473:pathology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000473:pathology*; D008297:Male; D009336:Necrosis; D010920:Placenta / Q000473:pathology*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D013588:Syphilis Serodiagnosis; D013590:Syphilis, Congenital / Q000473:pathology*; D013601:T-Lymphocytes / Q000473:pathology; D014470:Umbilical Cord / Q000473:pathology; D055815:Young Adult
keywords: Serological testing; Social environment; Therapy decision; Treponema pallidum; Viral coinfection