title: Synthesis of 4-Isoxazolines through Gold(I)-Catalyzed Cyclization of Propargylic N-Hydroxylamines.
abstract: New catalytic methods for the synthesis of 4-isoxazolines have been developed via catalytic intramolecular cyclizations of propargylic N-hydroxylamines. The reactions proceed rapidly in less than 1 h at room temperature in the presence of 5 mol % (PPh3)AuCl/5 mol % AgOTf or 5 mol % (PPh3)AuNTf2. This process features an efficient route to 4-isoxazolines with high yields, short reaction times, and mild reaction conditions.
authors.affiliation: College of Pharmacy & Graduate School of Pharmaceutical Sciences, Ewha Womans University , 52 Ewhayeodae-gil, Seodaemun-Gu, Seoul 03760, Republic of Korea.
authors.forename: B
authors.initials: B
authors.lastname: Chandrasekhar
authors.affiliation: College of Pharmacy & Graduate School of Pharmaceutical Sciences, Ewha Womans University , 52 Ewhayeodae-gil, Seodaemun-Gu, Seoul 03760, Republic of Korea.
authors.forename: Sewon
authors.initials: S
authors.lastname: Ahn
authors.affiliation: College of Pharmacy & Graduate School of Pharmaceutical Sciences, Ewha Womans University , 52 Ewhayeodae-gil, Seodaemun-Gu, Seoul 03760, Republic of Korea.
authors.forename: Jae-Sang
authors.initials: JS
authors.lastname: Ryu