title: Palladium-catalysed direct C-2 methylation of indoles.
abstract: A direct C-2 methylation reaction of indoles bearing a readily removable N-2-pyrimidyl moiety as a site-specific directing group has been developed with a palladium catalyst. This reaction relied on the use of KF to promote efficient methylation. A moderate to good yield was achieved in a range of indole substrates.
authors.affiliation: Department of Pharmaceutical Engineering, School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, China. chaojiang@njust.edu.cn.
authors.forename: Daoquan
authors.initials: D
authors.lastname: Tu
authors.forename: Xiuzhi
authors.initials: X
authors.lastname: Cheng
authors.forename: Yadong
authors.initials: Y
authors.lastname: Gao
authors.forename: Panpan
authors.initials: P
authors.lastname: Yang
authors.forename: Yousong
authors.initials: Y
authors.lastname: Ding
authors.forename: Chao
authors.initials: C
authors.lastname: Jiang