title: Sex differences and pathology status correlated to the toxicity of some common carcinogens in experimental skin carcinoma.
abstract: The increased susceptibility of men as compared to women to develop different types of cancer, including skin cancer, is well known; however, the mechanisms involved in this process are still a matter of debate. This study aimed to obtain animal models of photo-chemically-induced skin carcinogenesis by exposure to ultraviolet radiation B (UVB) coupled with topical applications of a tumor initiator (7,12-dimethylbenz(a)anthracene, DMBA) and a tumor promoter (12-O-tetradecanoylphorbol-13-acetate, TPA) in order to characterize the gender disparities regarding the skin lesions developed by the female and male SKH-1 hairless mice included in this study. Histopathological analysis confirmed the presence of malignant lesions in both cases, in female and male mice, following chronic exposure (24 weeks) to the noxious effects of the carcinogens applied, whereas the tumors in male mice had a more severe histological grade. In addition, tumor incidence, size and multiplicity were higher in male mice than in female mice.
authors.affiliation: Faculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., Timisoara, 300041, Romania. Electronic address: cadehelean@umft.ro.
authors.forename: Cristina A
authors.initials: CA
authors.lastname: Dehelean
authors.affiliation: Faculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., Timisoara, 300041, Romania. Electronic address: codrutasoica@umft.ro.
authors.forename: Codruta
authors.initials: C
authors.lastname: Soica
authors.affiliation: Faculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., Timisoara, 300041, Romania. Electronic address: iuliapinzaru@umft.ro.
authors.forename: Iulia
authors.initials: I
authors.lastname: Pinzaru
authors.affiliation: Faculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., Timisoara, 300041, Romania. Electronic address: dorinacoricovac@umft.ro.
authors.forename: Dorina
authors.initials: D
authors.lastname: Coricovac
authors.affiliation: Faculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., Timisoara, 300041, Romania. Electronic address: corina_tiulea@yahoo.com.
authors.forename: Corina
authors.initials: C
authors.lastname: Danciu
authors.affiliation: Faculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., Timisoara, 300041, Romania. Electronic address: ioanaz.pavel@yahoo.com.
authors.forename: Ioana
authors.initials: I
authors.lastname: Pavel
authors.affiliation: Faculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., Timisoara, 300041, Romania. Electronic address: fborcan@umft.ro.
authors.forename: Florin
authors.initials: F
authors.lastname: Borcan
authors.affiliation: Laboratory of Clinical Virology, School of Medicine, University of Crete, Heraklion, 71003, Greece.
authors.forename: Demetrios A
authors.initials: DA
authors.lastname: Spandidos
authors.affiliation: Department of Forensic Sciences and Toxicology, Medical School, University of Crete, Heraklion, 71003, Greece.
authors.forename: Aristidis M
authors.initials: AM
authors.lastname: Tsatsakis
authors.affiliation: Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., Timisoara, 300041, Romania. Electronic address: flaviabaderca@yahoo.com.
authors.forename: Flavia
authors.initials: F
authors.lastname: Baderca
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity*; D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D012737:Sex Factors; D012878:Skin Neoplasms / Q000139:chemically induced / Q000473:pathology*; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity*
chemical_list: D002273:Carcinogens; D015127:9,10-Dimethyl-1,2-benzanthracene; D013755:Tetradecanoylphorbol Acetate
keywords: DMBA; Gender differences; Histopathological examination; TPA; UVB