title: Alteration in bone geometric and mechanical properties, histomorphometrical parameters of trabecular bone, articular cartilage, and growth plate in adolescent rats after chronic co-exposure to cadmium and lead in the case of supplementation with green, black, red and white tea.
abstract: Adolescent male Wistar rats were used to check whether regular consumption of black, red, white, or green tea would have a protective effect on femur development during 12-week exposure to Cd and Pb (7mg Cd and 50mg Pb in 1kg of the diet). The animals were randomly divided (n=12) into a positive control (without Cd, Pb and teas), a negative control group (Cd and Pb), and groups supplemented additionally with green (GT), black (BT), red (RT), and white tea (WT). Heavy metals reduced the geometric and densitometric parameters and the total thickness of articular cartilage irrespective of tea administration and influenced mechanical endurance, growth plate thickness, and trabecular histomorphometry depending on the tea type. It is difficult to indicate which tea has the best protective effects on bone and hyaline cartilage against heavy metal action.
authors.affiliation: Department of Animal Physiology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, 20-950 Lublin, Poland. Electronic address: ewaRST@interia.pl.
authors.forename: Ewa
authors.initials: E
authors.lastname: Tomaszewska
authors.affiliation: Department of Comparative Anatomy and Anthropology, Maria Curie-Skłodowska University, 20-033 Lublin, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Dobrowolski
authors.affiliation: Department of Bromatology and Food Physiology, University of Life Sciences in Lublin, 20-950 Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Winiarska-Mieczan
authors.affiliation: Department of Bromatology and Food Physiology, University of Life Sciences in Lublin, 20-950 Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Kwiecień
authors.affiliation: Department of Animal Physiology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, 20-950 Lublin, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Tomczyk
authors.affiliation: Department of Physics, Faculty of Production Engineering, University of Life Sciences in Lublin, Poland.
authors.forename: Siemowit
authors.initials: S
authors.lastname: Muszyński
authors.affiliation: Department of Animal Physiology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, 20-950 Lublin, Poland.
authors.forename: Radosław
authors.initials: R
authors.lastname: Radzki
mesh_terms: D000367:Age Factors; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D015519:Bone Density / Q000187:drug effects; D002104:Cadmium / Q000097:blood / Q000633:toxicity*; D002118:Calcium / Q000032:analysis; D000071556:Cancellous Bone / Q000187:drug effects*; D002358:Cartilage, Articular; D019587:Dietary Supplements; D005506:Food Contamination; D006132:Growth Plate / Q000187:drug effects*; D007854:Lead / Q000097:blood / Q000633:toxicity*; D008297:Male; D020011:Protective Agents / Q000494:pharmacology; D017208:Rats, Wistar; D013662:Tea; D036401:Toxicity Tests, Chronic
chemical_list: D020011:Protective Agents; D013662:Tea; D002104:Cadmium; D007854:Lead; D002118:Calcium
keywords: Adolescent rats; Cadmium; Femur geometry; Lead; Mechanical endurance; Tea