title: Raiders of the lost mark - endothelial cells and their role in transplantation for hematologic malignancies.
abstract: Endothelial cells (EC) are crucial for normal angiogenesis and important for patients with leukemia, myeloma, and lymphoma during and after hematopoietic stem cell transplantation (HSCT). Knowledge of endothelial dysfunction in hematologic malignancies is provided by translational studies analyzing soluble endothelial markers, morphologic and functional changes of EC cultured in patients' sera or enumeration of circulating EC or endothelial progenitor cells (EPC). EC are important for stem cell homing and maintenance. Endothelial activation or damage is a central component in the pathogenesis of several complications after HSCT, like acute and chronic graft-versus-host disease, sinusoidal obstruction syndrome, capillary leak syndrome, engraftment syndrome, diffuse alveolar syndrome, idiopathic pneumonia syndrome, and transplant-associated microangiopathy. Finally, EC or EPC may facilitate tumor cell survival thus representing potential factors for both disease progression and relapse in hematologic malignancies.
authors.affiliation: a Immunology Research Group, Institute of Medical Biology , UiT the Arctic University of Norway , Tromsø , Norway.|b Department of Oncology , University Hospital of North Norway , Tromsø , Norway.
authors.forename: Egil S
authors.initials: ES
authors.lastname: Blix
authors.affiliation: a Immunology Research Group, Institute of Medical Biology , UiT the Arctic University of Norway , Tromsø , Norway.
authors.forename: Anne
authors.initials: A
authors.lastname: Husebekk
mesh_terms: D015415:Biomarkers; D001853:Bone Marrow / Q000378:metabolism / Q000473:pathology; D002318:Cardiovascular Diseases / Q000209:etiology; D002450:Cell Communication; D002470:Cell Survival; D042783:Endothelial Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D066026:Endothelial Progenitor Cells / Q000166:cytology / Q000378:metabolism; D006086:Graft vs Host Disease / Q000209:etiology / Q000378:metabolism; D019337:Hematologic Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000378:metabolism; D006801:Humans; D009389:Neovascularization, Pathologic / Q000378:metabolism; D011379:Prognosis; D011485:Protein Binding; D012008:Recurrence; D015398:Signal Transduction; D019172:Transplantation Conditioning / Q000009:adverse effects
chemical_list: D015415:Biomarkers
keywords: Endothelial cells; endothelial progenitor cells; graft-versus-host disease; hematopoietic stem cell transplantation