title: Recent advances in the synthesis of indolizines and their π-expanded analogues.
abstract: Indolizine (pyrrolo[1,2-a]pyridine) is one of the five isomers of indole and it serves as a precursor for widespread indolizidine alkaloids. The straightforward synthesis of indolizines based on classical methodologies such as Scholtz or Chichibabin reactions has overshadowed numerous new strategies that have been revealed especially within the last ten years. The desire to achieve substitution patterns which were hard to build sparked the discovery of completely new pathways, e.g. transition metal-catalyzed reactions and approaches based on oxidative coupling. In this review, selected strategies toward indolizines published since 2005 are briefly summarized, commented upon, compared, and illustrated. The literature discussed here involves reactions based on either pyridine or pyrrole scaffolds, as well as selected methodologies leading to π-expanded indolizines.
authors.affiliation: Institute of Organic Chemistry of the Polish Academy of Sciences, 01-224 Warsaw, Poland. dtgryko@icho.edu.pl.
authors.forename: Bartłomiej
authors.initials: B
authors.lastname: Sadowski
authors.affiliation: Institute of Organic Chemistry of the Polish Academy of Sciences, 01-224 Warsaw, Poland. dtgryko@icho.edu.pl.
authors.forename: Jan
authors.initials: J
authors.lastname: Klajn
authors.affiliation: Institute of Organic Chemistry of the Polish Academy of Sciences, 01-224 Warsaw, Poland. dtgryko@icho.edu.pl.
authors.forename: Daniel T
authors.initials: DT
authors.lastname: Gryko