title: Potential Roles of Amiloride-Sensitive Sodium Channels in Cancer Development.
abstract: The ENaC/degenerin ion channel superfamily includes the amiloride-sensitive epithelial sodium channel (ENaC) and acid sensitive ionic channel (ASIC). ENaC is a multimeric ion channel formed by heteromultimeric membrane glycoproteins, which participate in a multitude of biological processes by mediating the transport of sodium (Na(+)) across epithelial tissues such as the kidney, lungs, bladder, and gut. Aberrant ENaC functions contribute to several human disease states including pseudohypoaldosteronism, Liddle syndrome, cystic fibrosis, and salt-sensitive hypertension. Increasing evidence suggests that ion channels not only regulate ion homeostasis and electric signaling in excitable cells but also play important roles in cancer cell behaviors such as proliferation, apoptosis, invasion, and migration. Indeed, ENaCs/ASICs had been reported to be associated with cancer characteristics. Given their cell surface localization and pharmacology, pharmacological strategies to target ENaC/ASIC family members may be promising cancer therapeutics.
authors.affiliation: Institute of Lung and Molecular Therapy, Xinxiang Medical University, Xinxiang, Henan 453003, China; Center for Cancer Research, Xinxiang Medical University, Xinxiang, Henan 453003, China.
authors.forename: Siguang
authors.initials: S
authors.lastname: Xu
authors.affiliation: Center for Cancer Research, Xinxiang Medical University, Xinxiang, Henan 453003, China.
authors.forename: Cui
authors.initials: C
authors.lastname: Liu
authors.affiliation: Institute of Lung and Molecular Therapy, Xinxiang Medical University, Xinxiang, Henan 453003, China.
authors.forename: Yana
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Institute of Lung and Molecular Therapy, Xinxiang Medical University, Xinxiang, Henan 453003, China; Department of Cellular and Molecular Biology, University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA; Texas Lung Injury Institute, University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA.
authors.forename: Hong-Long
authors.initials: HL
authors.lastname: Ji
authors.affiliation: Center for Cancer Research, Xinxiang Medical University, Xinxiang, Henan 453003, China.
authors.forename: Xiumin
authors.initials: X
authors.lastname: Li
mesh_terms: D062565:Acid Sensing Ion Channels / Q000737:chemistry / Q000502:physiology*; D000584:Amiloride / Q000737:chemistry*; D000818:Animals; D017209:Apoptosis; D002465:Cell Movement; D049109:Cell Proliferation; D053503:Epithelial Sodium Channels / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000503:physiopathology*; D015398:Signal Transduction; D012964:Sodium / Q000737:chemistry
chemical_list: D062565:Acid Sensing Ion Channels; D053503:Epithelial Sodium Channels; D000584:Amiloride; D012964:Sodium