title: Extremely Stable Supramolecular Hydrogels Assembled from Nonionic Peptide Amphiphiles.
abstract: Peptide hydrogels with high stability in different media are of great interest in biomedical applications. In this paper, we report an easy, fast, and scalable method for preparing a family of nonionic peptide amphiphiles (PAs) obtained by direct aminolysis of alkyl-oilgo(γ-benzyl-l-glutamate) samples, which were synthesized via the alkyl amine-initiated sequence ring-opening reaction of α-amino acid N-carboxyanhydrides. One great advantage of this method is that vast chemical diversity and large-scale yields can be achieved easily using commercially available hydramines. These PA samples can readily form a clear hydrogel without any external aid and show exceptionally enhanced gelation properties with a critical gelation concentration as low as 0.05 wt %. The hydrogels are highly stable against extreme pH values of 1 and 14 and a high salt concentration of 200 mM NaCl. These properties combined with the shear-thinning properties make these PA hydrogels ideal candidates for the new generation of injectable scaffolds.
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.
authors.forename: Yaoming
authors.initials: Y
authors.lastname: Wan
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.
authors.forename: Zuoning
authors.initials: Z
authors.lastname: Wang
authors.affiliation: School of Polymer Science and Engineering, Qingdao University of Science and Technology , Qingdao 266042, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Sun
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.|School of Polymer Science and Engineering, Qingdao University of Science and Technology , Qingdao 266042, China.
authors.forename: Zhibo
authors.initials: Z
authors.lastname: Li
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D000812:Anhydrides / Q000737:chemistry; D004355:Drug Stability; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D049329:Nanostructures / Q000737:chemistry / Q000648:ultrastructure*; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry*; D012965:Sodium Chloride / Q000737:chemistry
chemical_list: D000596:Amino Acids; D000812:Anhydrides; D020100:Hydrogels; D010455:Peptides; D012965:Sodium Chloride