title: Zika Virus Infection Associated With Severe Thrombocytopenia.
abstract: We report two patients that developed severe thrombocytopenia after Zika virus (ZIKV) infection. The first patient had 1000 platelets/μL and died after multiple hemorrhages. The second patient had 2000 platelets/μL, had melena and ecchymoses, and recovered after receiving intravenous immunoglobulin. ZIKV may be associated with immune-mediated severe thrombocytopenia.
authors.affiliation: Dengue Branch.
authors.forename: Tyler M
authors.initials: TM
authors.lastname: Sharp
authors.affiliation: Dengue Branch.
authors.forename: Jorge
authors.initials: J
authors.lastname: Muñoz-Jordán
authors.affiliation: Dengue Branch.
authors.forename: Janice
authors.initials: J
authors.lastname: Perez-Padilla
authors.affiliation: Puerto Rico Department of Health, San Juan.
authors.forename: Melissa I
authors.initials: MI
authors.lastname: Bello-Pagán
authors.affiliation: Dengue Branch.
authors.forename: Aidsa
authors.initials: A
authors.lastname: Rivera
authors.affiliation: Division of Vector-Borne Diseases University of Colorado, Denver.
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Pastula
authors.affiliation: Epidemic Intelligence Service.
authors.forename: Jorge L
authors.initials: JL
authors.lastname: Salinas
authors.affiliation: San Juan City Hospital.
authors.forename: Jose H
authors.initials: JH
authors.lastname: Martínez Mendez
authors.affiliation: Hospital HIMA San Pablo, Bayamón, Puerto Rico.
authors.forename: Mónica
authors.initials: M
authors.lastname: Méndez
authors.affiliation: Arboviral Diseases Branch, Centers for Disease Control and Prevention.
authors.forename: Ann M
authors.initials: AM
authors.lastname: Powers
authors.affiliation: Dengue Branch.
authors.forename: Stephen
authors.initials: S
authors.lastname: Waterman
authors.affiliation: Puerto Rico Department of Health, San Juan.
authors.forename: Brenda
authors.initials: B
authors.lastname: Rivera-García
mesh_terms: D000328:Adult; D000368:Aged; D006801:Humans; D016756:Immunoglobulins, Intravenous; D008297:Male; D013921:Thrombocytopenia / Q000628:therapy / Q000821:virology*; D016896:Treatment Outcome; D000071243:Zika Virus Infection / Q000503:physiopathology* / Q000628:therapy
chemical_list: D016756:Immunoglobulins, Intravenous
keywords: Puerto Rico; Zika virus; fatal; thrombocytopenia