title: miR-132 mediates a metabolic shift in prostate cancer cells by targeting Glut1.
abstract: Prostate cancer is the second leading cause of cancer-related deaths among men worldwide. Early diagnosis increases survival rates in patients but the survival rate has remained relatively poor over the past years. Increasing evidence shows that altered metabolism is a critical hallmark in prostate cancer. There is a strong need to explore the molecular mechanisms underlying cancer metabolism for prostate cancer therapy. Whether the aberrant expression of microRNA (miRNA) contributes to cancer metabolism is not fully known. In this study, we found that microRNA-132 (miR-132) expression is reduced and thus leads to a metabolic switch in prostate cancer cells. miR-132 performs this role by increasing Glut1 expression, resulting in the enhanced rate of lactate production and glucose uptake. The altered metabolism induced by decreased miR-132 levels confers the rapid growth of the cancer cells. These data indicate that miR-132 is involved in regulating the Warburg effect in prostate cancer by inhibiting Glut1 expression.
authors.affiliation: Department of Nuclear Medicine The Second Affiliated Hospital of Medical School of Xi'an Jiaotong University Shaanxi China.
authors.forename: Wei
authors.initials: W
authors.lastname: Qu
authors.affiliation: Department of Endocrinology The Second Affiliated Hospital of Medical School of Xi'an Jiaotong University Shaanxi China.
authors.forename: Shi-Mei
authors.initials: SM
authors.lastname: Ding
authors.affiliation: Department of General Surgery The Second Affiliated Hospital of Medical School of Xi'an Jiaotong University Shaanxi China.
authors.forename: Gang
authors.initials: G
authors.lastname: Cao
authors.affiliation: Department of Nuclear Medicine The Second Affiliated Hospital of Medical School of Xi'an Jiaotong University Shaanxi China.
authors.forename: She-Jiao
authors.initials: SJ
authors.lastname: Wang
authors.affiliation: Department of Nuclear Medicine The Second Affiliated Hospital of Medical School of Xi'an Jiaotong University Shaanxi China.
authors.forename: Xiang-Hong
authors.initials: XH
authors.lastname: Zheng
authors.affiliation: Department of Nuclear Medicine The Second Affiliated Hospital of Medical School of Xi'an Jiaotong University Shaanxi China.
authors.forename: Guo-Hui
authors.initials: GH
authors.lastname: Li
keywords: Glut1; glycolysis; miR‐132; prostate cancer cell