title: Dietary Sucrose Lowers Nociceptive Latencies Independently of Thermogenic Effects.
abstract: Previous reports indicate that chronic sucrose feeding produces a significant reduction in the latency of response in the radiant heat tail-flick test. Other earlier studies have shown a relationship between tail-skin temperature and tail-flick latency, while others yet have shown an increase in tail-skin temperature following sucrose feeding. Together these previous findings suggest the possibility that dietary-induced alterations in nociceptive latencies occur as an artifact secondary to diet-related changes in tail-skin temperature. The data presented in this study show that chronic sucrose feeding significantly increased tail-skin temperature (p < 0.0001) and decreased tail-flick latency (p < 0.0001) with significant correlations between tail-skin temperatures and tail-flick latencies in both the control and sucrose fed groups. However, while the slopes of the regression lines were similar for both groups, the elevations of the lines were significantly different (p = 0.0068) suggesting a dietary impact on nociceptive thresholds independent of the temperature effect. The data were also subjected to a previously reported temperature-correction procedure and comparisons in the methods of data analysis are discussed.
authors.affiliation: a School of Pharmacy, Northeast Louisiana University , Monroe , LA 71209 , USA.
authors.forename: J K
authors.initials: JK
authors.lastname: Bounds
authors.affiliation: a School of Pharmacy, Northeast Louisiana University , Monroe , LA 71209 , USA.
authors.forename: D S
authors.initials: DS
authors.lastname: Roane
keywords: Diet; Feeding; Nociception; Sucrose; Tail-flick; Temperature