title: Effects of β-blockers on left ventricular remodeling in patients with preserved ejection fraction after acute myocardial infarction.
abstract: BACKGROUND
  The effects of β-blockers on left ventricular (LV) remodeling have been established in patients with reduced ejection fraction (EF) after acute myocardial infarction (AMI). In AMI patients with preserved EF, additional effects of β-blockers on reperfusion therapy and current medical treatment have not been elucidated.
  
  
  METHODS
  Patients with preserved EF (≥40%), who underwent percutaneous coronary intervention (PCI) for AMI and obtained complete coronary revascularization were enrolled retrospectively. These were divided into groups treated with or without β-blockers at discharge. Echocardiography was performed on admission and 8months after PCI to observe LVEF, LV end diastolic volume index (LVEDVI), LV end systolic volume index (LVESVI), LV end diastolic diameter (LVDd), and LV end systolic diameter (LVDs).
  
  
  RESULTS
  A total of 114 patients were enrolled; 81 were treated with β-blockers (β-blocker group) and 33 were treated without β-blockers (non-β-blocker group). All patients were prescribed antiplatelets and 96% took either an angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker. At follow-up, EF improved in both groups (2.6% in the β-blocker group and 4.6% in the non-β-blocker group). In the β-blocker group, neither LVEDVI nor LVESVI decreased. However, both LVEDVI (-4.3ml/m(2)) and LVESVI (-4.1ml/m(2)) improved in the non-β-blocker group. There were significant increases in LVDd (2.1mm) and LVDs (2.2mm) in the β-blocker group, whereas these parameters did not significantly change in the non-β-blocker group.
  
  
  CONCLUSIONS
  Effects of β-blockers on LV remodeling were uncertain in AMI patients with preserved EF, who obtained complete coronary revascularization and received optimal medical treatment.
authors.affiliation: Division of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan.
authors.forename: Yu
authors.initials: Y
authors.lastname: Horiuchi
authors.affiliation: Division of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan. Electronic address: shuzou_bushido@msn.com.
authors.forename: Shuzou
authors.initials: S
authors.lastname: Tanimoto
authors.affiliation: Division of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan.
authors.forename: Jiro
authors.initials: J
authors.lastname: Aoki
authors.affiliation: Division of General Medicine, Mitsui Memorial Hospital, Tokyo, Japan.
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Nakajima
authors.affiliation: Division of Internal Medicine, Mitsui Memorial Hospital, Tokyo, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Hara
authors.affiliation: Division of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan.
authors.forename: Kengo
authors.initials: K
authors.lastname: Tanabe
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology* / Q000627:therapeutic use*; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D062645:Percutaneous Coronary Intervention / Q000639:trends; D012189:Retrospective Studies; D013318:Stroke Volume / Q000187:drug effects* / Q000502:physiology; D016896:Treatment Outcome; D020257:Ventricular Remodeling / Q000187:drug effects* / Q000502:physiology
chemical_list: D000319:Adrenergic beta-Antagonists
keywords: Acute myocardial infarction; Heart failure with preserved ejection fraction; β-Blocker