title: [Severe infection by methicillin sensitive Staphylococcus aureus producing Panton-Valentine leukocidin: reports of two cases].
abstract: Staphylococcus aureus is a major etiologic agent of infections in children from the community and the hospital setting. The severity of these conditions is associated with virulence factors, including the Panton-Valentine leukocidin. Both methicillin resistant and sensitive Staphylococcus aureus produce this leukocidin although with varying frequency. We present two children with severe infection by sensitive Staphylococcus aureus producer of Panton-Valentine leukocidin with musculoskeletal and endovascular complications. It is essential the suspected diagnosis, appropriate antibiotic treatment and early surgical management to improve the approach of these infections. Epidemiological surveillance should be mantained to detect the frequency of infections caused by these bacteria.
authors.affiliation: Servicio de Control Epidemiológico e Infectología, Hospital de Pediatría "Profesor Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires, Argentina. martin.brizuela1984@gmail.com.
authors.forename: Martín
authors.initials: M
authors.lastname: Brizuela
authors.affiliation: Servicio de Control Epidemiológico e Infectología, Hospital de Pediatría "Profesor Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Pérez
authors.affiliation: Servicio de Control Epidemiológico e Infectología, Hospital de Pediatría "Profesor Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Silvina
authors.initials: S
authors.lastname: Ruvinsky
authors.affiliation: Servicio de Control Epidemiológico e Infectología, Hospital de Pediatría "Profesor Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Claudia
authors.initials: C
authors.lastname: Sarkis
authors.affiliation: Servicio de Microbiología, Hospital de Pediatría "Profesor Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Romina
authors.initials: R
authors.lastname: Romero
authors.affiliation: Servicio de Microbiología, Hospital de Pediatría "Profesor Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Alejandra
authors.initials: A
authors.lastname: Mastroianni
authors.affiliation: Servicio de Microbiología, Hospital de Pediatría "Profesor Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Lidia
authors.initials: L
authors.lastname: Casimir
authors.affiliation: Servicio de Microbiología, Hospital de Pediatría "Profesor Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: María E
authors.initials: ME
authors.lastname: Venuta
authors.affiliation: Servicio de Microbiología, Hospital de Pediatría "Profesor Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Verónica
authors.initials: V
authors.lastname: Gómez Bonduele
authors.affiliation: Servicio de Control Epidemiológico e Infectología, Hospital de Pediatría "Profesor Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Rosa
authors.initials: R
authors.lastname: Bologna
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001427:Bacterial Toxins / Q000096:biosynthesis*; D002648:Child; D005098:Exotoxins / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007956:Leukocidins / Q000096:biosynthesis*; D008297:Male; D008712:Methicillin / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D012720:Severity of Illness Index; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000382:microbiology / Q000628:therapy; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin; D008712:Methicillin
keywords: Invasive disease; Methicillin resistance; Panton-Valentine leukocidin; Staphylococcus aureus