title: Gene expression of proteins of the vesicle cycle in dopaminergic neurons in modeling of Parkinson's disease.
abstract: It is assumed that one of the causes of the degeneration of dopaminergic neurons is the dysregulation of the vesicle cycle, which is ensured by a number of proteins including syntaxin I, synaptotagmin I, complexins I and II, and Rab5. It was shown that there is a compensatory increase in gene expression of proteins responsible for exocytosis at the preclinical stage of Parkinson's disease (PD) in the in substantia nigra (SN) in mice. Conversely, in the model of the clinical stage of PD, the decreases of gene expression of proteins responsible for exocytosis, endocytosis, and neuronal survival, which may be among the triggers of motor dysfunctions.
authors.affiliation: Koltzov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow, 119334, Russia. edik173@mail.ru.
authors.forename: E R
authors.initials: ER
authors.lastname: Mingazov
authors.affiliation: Koltzov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow, 119334, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Ugrumov
mesh_terms: D033942:Adaptor Proteins, Vesicular Transport / Q000378:metabolism; D000818:Animals; D059290:Dopaminergic Neurons / Q000378:metabolism*; D015870:Gene Expression; D007041:Hypoxanthine Phosphoribosyltransferase / Q000378:metabolism; D020267:MPTP Poisoning / Q000378:metabolism*; D008297:Male; D008810:Mice, Inbred C57BL; D009419:Nerve Tissue Proteins / Q000378:metabolism; D062706:Prodromal Symptoms; D012333:RNA, Messenger / Q000378:metabolism; D013378:Substantia Nigra / Q000378:metabolism*; D050863:Synaptotagmin I / Q000378:metabolism; D050827:Syntaxin 1 / Q000378:metabolism; D020696:rab5 GTP-Binding Proteins / Q000378:metabolism
chemical_list: D033942:Adaptor Proteins, Vesicular Transport; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D050863:Synaptotagmin I; D050827:Syntaxin 1; C494311:Syt1 protein, mouse; C095992:complexin I; C095993:complexin II; D007041:Hypoxanthine Phosphoribosyltransferase; D020696:rab5 GTP-Binding Proteins