title: The Synthetic Elicitor DPMP (2,4-dichloro-6-{(E)-[(3-methoxyphenyl)imino]methyl}phenol) Triggers Strong Immunity in Arabidopsis thaliana and Tomato.
abstract: Synthetic elicitors are drug-like compounds that are structurally distinct from natural defense elicitors. They can protect plants from diseases by activating host immune responses and can serve as tools for the dissection of the plant immune system as well as leads for the development of environmentally-safe pesticide alternatives. By high-throughput screening, we previously identified 114 synthetic elicitors that activate expression of the pathogen-responsive CaBP22(-333)::GUS reporter gene in Arabidopsis thaliana (Arabidopsis), 33 of which are [(phenylimino)methyl]phenol (PMP) derivatives or PMP-related compounds. Here we report on the characterization of one of these compounds, 2,4-dichloro-6-{(E)-[(3-methoxyphenyl)imino]methyl}phenol (DPMP). DPMP strongly triggers disease resistance of Arabidopsis against bacterial and oomycete pathogens. By mRNA-seq analysis we found transcriptional profiles triggered by DPMP to resemble typical defense-related responses.
authors.affiliation: Center for Plant Cell Biology, Institute for Integrative Genome Biology, University of California at Riverside, CA 92521, USA.|Department of Botany and Plant Sciences, University of California at Riverside, CA 92521, USA.
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Bektas
authors.affiliation: Center for Plant Cell Biology, Institute for Integrative Genome Biology, University of California at Riverside, CA 92521, USA.|Department of Botany and Plant Sciences, University of California at Riverside, CA 92521, USA.|ChemGen Intergrative Graduate Education and Research Traineeship program, program, University of California at Riverside, CA 92521, USA.
authors.forename: Melinda
authors.initials: M
authors.lastname: Rodriguez-Salus
authors.affiliation: Center for Plant Cell Biology, Institute for Integrative Genome Biology, University of California at Riverside, CA 92521, USA.|Department of Botany and Plant Sciences, University of California at Riverside, CA 92521, USA.|ChemGen Intergrative Graduate Education and Research Traineeship program, program, University of California at Riverside, CA 92521, USA.
authors.forename: Mercedes
authors.initials: M
authors.lastname: Schroeder
authors.affiliation: Department of Botany and Plant Sciences, University of California at Riverside, CA 92521, USA.
authors.forename: Adilene
authors.initials: A
authors.lastname: Gomez
authors.affiliation: Center for Plant Cell Biology, Institute for Integrative Genome Biology, University of California at Riverside, CA 92521, USA.|Department of Nematology, University of California at Riverside, CA 92521, USA.
authors.forename: Isgouhi
authors.initials: I
authors.lastname: Kaloshian
authors.affiliation: Center for Plant Cell Biology, Institute for Integrative Genome Biology, University of California at Riverside, CA 92521, USA.|Department of Botany and Plant Sciences, University of California at Riverside, CA 92521, USA.|ChemGen Intergrative Graduate Education and Research Traineeship program, program, University of California at Riverside, CA 92521, USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Eulgem
mesh_terms: D017360:Arabidopsis / Q000187:drug effects* / Q000276:immunology*; D029681:Arabidopsis Proteins / Q000378:metabolism; D002147:Calmodulin / Q000378:metabolism; D060467:Disease Resistance; D018506:Gene Expression Regulation, Plant / Q000187:drug effects; D059165:Hormesis / Q000187:drug effects; D054884:Host-Pathogen Interactions / Q000187:drug effects / Q000276:immunology; D007097:Imines / Q000494:pharmacology*; D018551:Solanum lycopersicum / Q000187:drug effects* / Q000276:immunology*; D010636:Phenols / Q000494:pharmacology*; D010935:Plant Diseases / Q000276:immunology* / Q000382:microbiology / Q000517:prevention & control*; D057865:Plant Immunity; D044224:Pseudomonas syringae / Q000472:pathogenicity; D059467:Transcriptome / Q000187:drug effects
chemical_list: D029681:Arabidopsis Proteins; C542165:CaBP22 protein, Arabidopsis; D002147:Calmodulin; D007097:Imines; D010636:Phenols