title: Stroke volume changes induced by a recruitment maneuver predict fluid responsiveness in patients with protective ventilation in the operating theater.
abstract: During abdominal surgery, the use of protective ventilation with a low tidal volume, positive expiratory pressure (PEEP) and recruitment maneuvers (RMs) may limit the applicability of dynamic preload indices. The objective of the present study was to establish whether or not the variation in stroke volume (SV) during an RM could predict fluid responsiveness.We prospectively included patients receiving protective ventilation (tidal volume: 6 mL kg, PEEP: 5-7 cmH2O; RMs). Hemodynamic variables, such as heart rate, arterial pressure, SV, cardiac output (CO), respiratory variation in SV (ΔrespSV) and pulse pressure (ΔrespPP), and the variation in SV (ΔrecSV) as well as pulse pressure (ΔrecPP) during an RM were measured at baseline, at the end of the RM, and after fluid expansion. Responders were defined as patients with an SV increase of at least 15% after infusion of 500 mL of crystalloid solution.Thirty-seven (62%) of the 60 included patients were responders. Responders and nonresponders differed significantly in terms of the median ΔrecSV (26% [19-37] vs 10% [4-12], respectively; P < 0.0001). A ΔrecSV value more than 16% predicted fluid responsiveness with an area under the receiver-operating characteristic curve (AU) of 0.95 (95% confidence interval [CI]: 0.91-0.99; P < 0.0001) and a narrow gray zone between 15% and 17%. The area under the curve values for ΔrecPP and ΔrespSV were, respectively, 0.81 (95%CI: 0.7-0.91; P = 0.0001) and 0.80 (95%CI: 0.70-0.94; P < 0.0001). ΔrespPP did not predict fluid responsiveness.During abdominal surgery with protective ventilation, a ΔrecSV value more than 16% accurately predicted fluid responsiveness and had a narrow gray zone (between 15% and 17%). ΔrecPP and ΔrespSV (but not ΔrespPP) were also predictive.
authors.affiliation: Anesthesiology and Critical Care Department, Amiens University Medical Center, Place Victor Pauchet, Amiens Pôle Réanimations Anesthésie SAMU/SMUR, CHU de Caen, Caen INSERM U1088, Jules Verne University of Picardy, Amiens, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: De Broca
authors.forename: Jeremie
authors.initials: J
authors.lastname: Garnier
authors.forename: Marc-Olivier
authors.initials: MO
authors.lastname: Fischer
authors.forename: Thomas
authors.initials: T
authors.lastname: Archange
authors.forename: Julien
authors.initials: J
authors.lastname: Marc
authors.forename: Osama
authors.initials: O
authors.lastname: Abou-Arab
authors.forename: Hervé
authors.initials: H
authors.lastname: Dupont
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Lorne
authors.forename: Pierre-Grégoire
authors.initials: PG
authors.lastname: Guinot
mesh_terms: D000005:Abdomen / Q000601:surgery*; D000768:Anesthesia, General; D001783:Blood Flow Velocity / Q000502:physiology; D001795:Blood Pressure Determination; D000077324:Crystalloid Solutions; D015150:Echocardiography, Doppler; D004562:Electrocardiography; D005260:Female; D005440:Fluid Therapy; D005602:France; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007430:Intraoperative Care; D007552:Isotonic Solutions; D008297:Male; D008875:Middle Aged; D010092:Oximetry; D011446:Prospective Studies; D012121:Respiration, Artificial / Q000379:methods*; D013318:Stroke Volume / Q000502:physiology*
chemical_list: D000077324:Crystalloid Solutions; D007552:Isotonic Solutions