title: Biphasic flow-volume loop in granulomatosis with polyangiitis related unilateral bronchus obstruction.
abstract: Spirometry flow-volume measurement is used routinely in the outpatient setting to rule out obstructive lung diseases. Biphasic flow-volume loop is a classic presentation of unilateral bronchial stenosis due to multiple etiologies and it should raise clinical suspicion. Granulomatosis with polyangiitis (GPA) is a systemic inflammatory condition with pulmonary manifestations that may be infiltrative (e.g., pneumonia), hemorrhagic, and may rarely cause bronchial stenosis. Herein, we present a case of GPA-related, bronchial obstruction that caused biphasic flow-volume loop along with a literature review.
authors.affiliation: Monmouth Medical Center, Department of Medicine, 300 s Avenue Long Branch, NJ 07740, USA. Electronic address: abhinav72@gmail.com.
authors.forename: Abhinav
authors.initials: A
authors.lastname: Agrawal
authors.affiliation: North Shore - Long Island Jewish Health System, Department of Pulmonary, Critical Care and Sleep Medicine, 410 Lakeville Rd. Suite 107 New Hyde Park, NY 11040, USA. Electronic address: sahni.sonu@gmail.com.
authors.forename: Sonu
authors.initials: S
authors.lastname: Sahni
authors.affiliation: North Shore - Long Island Jewish Health System, Department of Rheumatology, Manhasset, NY 11040, USA. Electronic address: gmarder@nshs.edu.
authors.forename: Galina
authors.initials: G
authors.lastname: Marder
authors.affiliation: North Shore - Long Island Jewish Health System, Department of Radiology, Manhasset, NY 11040, USA. Electronic address: rshah@nshs.edu.
authors.forename: Rakesh
authors.initials: R
authors.lastname: Shah
authors.affiliation: North Shore - Long Island Jewish Health System, Department of Pulmonary, Critical Care and Sleep Medicine, 410 Lakeville Rd. Suite 107 New Hyde Park, NY 11040, USA. Electronic address: arunabhtalwar1@gmail.com.
authors.forename: Arunabh
authors.initials: A
authors.lastname: Talwar
mesh_terms: D000402:Airway Obstruction / Q000209:etiology* / Q000503:physiopathology*; D001982:Bronchial Diseases / Q000209:etiology* / Q000503:physiopathology*; D014890:Granulomatosis with Polyangiitis / Q000150:complications*; D006801:Humans; D008297:Male; D008449:Maximal Expiratory Flow-Volume Curves; D055815:Young Adult
keywords: Biphasic flow volume curve; Granulomatosis with polyangiitis; Spirometry; Unilateral Bronchial obstruction; Upper airway disorder