title: A 980nm driven photothermal ablation of virulent and antibiotic resistant Gram-positive and Gram-negative bacteria strains using Prussian blue nanoparticles.
abstract: A 980nm laser-driven antimicrobial photothermal therapy using poly(vinylpyrrolidone) -coated Prussian Blue nanoparticles (PVP/PB NPs) is demonstrated. This approach allows an efficient eradication of a virulent strain of Gram-negative Escherichia coli (E. coli) associated with urinary tract infection as well as for the ablation of antibiotic resistant pathogens such as methicillin resistant Staphylococcus aureus (MRSA) and extended spectrum β-lactamase (ESBL) E. coli. Interestingly the 980nm irradiation exhibits minimal effect on mammalian cells up to a PVP/PB NPs concentration of 50μgmL(-1), while at this concentration bacteria are completely eradicated. This feature is certainly very promising for the selective targeting of bacteria over mammalian cells.
authors.affiliation: Institut d'Electronique, de Microélectronique et de Nanotechnologie (IEMN, UMR CNRS 8520), Université Lille 1, Avenue Poincaré, BP 60069, 59652 Villeneuve d'Ascq, France; Département de Physique, Faculté des Sciences de Tunis, Université Tunis-El Manar, 2092, Tunisia.
authors.forename: Houcem
authors.initials: H
authors.lastname: Maaoui
authors.affiliation: Institut d'Electronique, de Microélectronique et de Nanotechnologie (IEMN, UMR CNRS 8520), Université Lille 1, Avenue Poincaré, BP 60069, 59652 Villeneuve d'Ascq, France; Iasi Plasma Advanced Research Center (IPARC), Faculty of Physics, Alexandru Ioan Cuza University of Iasi, Bd. Carol I No. 11, Iasi 700506, Romania.
authors.forename: Roxana
authors.initials: R
authors.lastname: Jijie
authors.affiliation: State Key Laboratory of Luminescence and Applications, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, 3888 Dong Nanhu Road, Changchun 130033, China.
authors.forename: Guo-Hui
authors.initials: GH
authors.lastname: Pan
authors.affiliation: Université Lille 1, Institut Charles Viollette - EA 7394, Lille, France.
authors.forename: Djamel
authors.initials: D
authors.lastname: Drider
authors.affiliation: Université Lille 1, Institut Charles Viollette - EA 7394, Lille, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Caly
authors.affiliation: Unité de Glycobiologie Structurale et Fonctionnelle (UGSF), UMR 8576 CNRS, Université de Lille, 59000 Lille, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Bouckaert
authors.affiliation: Iasi Plasma Advanced Research Center (IPARC), Faculty of Physics, Alexandru Ioan Cuza University of Iasi, Bd. Carol I No. 11, Iasi 700506, Romania.
authors.forename: Nicoleta
authors.initials: N
authors.lastname: Dumitrascu
authors.affiliation: Centre des Recherches et des Technologies de l'Energie, B.P. 95, Hammam-Lif 2050, Tunisia.
authors.forename: Radouane
authors.initials: R
authors.lastname: Chtourou
authors.affiliation: Institut d'Electronique, de Microélectronique et de Nanotechnologie (IEMN, UMR CNRS 8520), Université Lille 1, Avenue Poincaré, BP 60069, 59652 Villeneuve d'Ascq, France.
authors.forename: Sabine
authors.initials: S
authors.lastname: Szunerits
authors.affiliation: Institut d'Electronique, de Microélectronique et de Nanotechnologie (IEMN, UMR CNRS 8520), Université Lille 1, Avenue Poincaré, BP 60069, 59652 Villeneuve d'Ascq, France. Electronic address: rabah.boukherroub@univ-lille1.fr.
authors.forename: Rabah
authors.initials: R
authors.lastname: Boukherroub
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D004352:Drug Resistance, Microbial / Q000187:drug effects*; D005295:Ferrocyanides / Q000737:chemistry*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D055668:Photochemical Processes; D013499:Surface Properties; D013696:Temperature
chemical_list: D000900:Anti-Bacterial Agents; D005295:Ferrocyanides; C000170:ferric ferrocyanide
keywords: Bacteria; Gram negative; Gram positive; Near infrared; Photothermal; Prussian blue