title: Leukemia in Patients with Klinefelter Syndrome: A Report of Two Cases.
abstract: Klinefelter syndrome (KS) is a chromosome abnormality characterized by a 47, XXY karyotype associated with hypogonadism and infertility. We present two cases of leukemia in patients with KS. The first patient presented with acute promyelocytic leukemia. He relapsed after the end of treatment. The second patient was diagnosed with chronic myeloid leukemia. Treatment with imatinib failed and the patient presented with myeloid blast crisis.
authors.affiliation: Department of Hematology, Aziza Othmana University Hospital, Place du gouvernement, la Kasbbah, 1008 Tunis, Tunisia.
authors.forename: M
authors.initials: M
authors.lastname: Bchir
authors.affiliation: Laboratory of Histology and Cytogenetics, Department of Histology and Cytogenetics, Faculty of Medicine of Tunis, Institut Pasteur de Tunis, El Manar Tunis University, 13, Place Pasteur, BP74, 1002 Tunis, Tunisia.
authors.forename: W
authors.initials: W
authors.lastname: Ayed
authors.affiliation: Department of Hematology, Aziza Othmana University Hospital, Place du gouvernement, la Kasbbah, 1008 Tunis, Tunisia.
authors.forename: H Ben
authors.initials: HB
authors.lastname: Neji
authors.affiliation: Laboratory of Histology and Cytogenetics, Department of Histology and Cytogenetics, Faculty of Medicine of Tunis, Institut Pasteur de Tunis, El Manar Tunis University, 13, Place Pasteur, BP74, 1002 Tunis, Tunisia.
authors.forename: O
authors.initials: O
authors.lastname: Kilani
authors.affiliation: Department of Hematology, Aziza Othmana University Hospital, Place du gouvernement, la Kasbbah, 1008 Tunis, Tunisia.
authors.forename: S
authors.initials: S
authors.lastname: Kefi
authors.affiliation: Department of Hematology, Aziza Othmana University Hospital, Place du gouvernement, la Kasbbah, 1008 Tunis, Tunisia.
authors.forename: M
authors.initials: M
authors.lastname: Zarrouk
authors.affiliation: Laboratory of Histology and Cytogenetics, Department of Histology and Cytogenetics, Faculty of Medicine of Tunis, Institut Pasteur de Tunis, El Manar Tunis University, 13, Place Pasteur, BP74, 1002 Tunis, Tunisia.
authors.forename: H
authors.initials: H
authors.lastname: Guermani
authors.affiliation: Laboratory of Histology and Cytogenetics, Department of Histology and Cytogenetics, Faculty of Medicine of Tunis, Institut Pasteur de Tunis, El Manar Tunis University, 13, Place Pasteur, BP74, 1002 Tunis, Tunisia.
authors.forename: S
authors.initials: S
authors.lastname: Hentati
authors.affiliation: Laboratory of Histology and Cytogenetics, Department of Histology and Cytogenetics, Faculty of Medicine of Tunis, Institut Pasteur de Tunis, El Manar Tunis University, 13, Place Pasteur, BP74, 1002 Tunis, Tunisia.
authors.forename: A
authors.initials: A
authors.lastname: Amouri
authors.affiliation: Department of Hematology, Aziza Othmana University Hospital, Place du gouvernement, la Kasbbah, 1008 Tunis, Tunisia.
authors.forename: B
authors.initials: B
authors.lastname: Meddeb
keywords: Acute promyelocytic leukemia; Chronic myelogenous leukemia; Karyotype; Klinefelter syndrome