title: Non-Diabetic renal disease in Diabetes Mellitus: clinical features and renal biopsy findings.
abstract: OBJECTIVE
  Renal diseases in diabetes mellitus (DM) patients, include diabetic nephropathies (DN) and non-diabetic renal diseases (NDRD). The clinical differentiation among them is usually not so clear and effective. Aim of this study which examined renal biopsies in patients with type-2 DM was to identify the prevalence and the nature of NDRD.
  
  
  METHODS
  We recorded the clinical and laboratory finding alongside with the histopathological examination of the renal biopsies obtained from 71 type-2 DM patients who underwent renal biopsy in our center. Based on the renal biopsy findings patients were classified into two groups (DN and NDRD) and data was compared between the two groups.
  
  
  RESULTS
  There were 42 women and 29 men; aged 55 ± 12 years. In patients with DN (n: 34), diabetic retinopathy was more common [16 (47.1 %) vs. 6 (16.2 %) respectively, p =0.01], duration of DM was longer (108.8 ± 58.8 months vs 57.8 ± 55.9 months respectively, p <0.001) and the degree of proteinuria was more severe (6 ± 4.3 g/day vs. 4.5 ± 4.6 g/day respectively, p =0.04) compared to the patients with NDRD. Regression analysis revealed that diabetes duration >60 months, presence of diabetic retinopathy and proteinuria >3.5 g/day were independent predictors of DN with 79.4 % sensitivity and 86.5% specificity. Focal segmental glomerulosclerosis was the most frequent diagnosis in patients with NDRD.
  
  
  CONCLUSIONS
  The prevalence of NDRD is remarkably frequent in DM patients in whom nephrologists consider renal biopsy an appropriate measure. Short duration of DM, degree of proteinuria and absence of retinopathy were predictors of NDRD. Hippokratia 2015; 19 (2):148-152.
authors.affiliation: Nephrology Department of Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: E C
authors.initials: EC
authors.lastname: Yenigun
authors.affiliation: Nephrology Department of Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: F
authors.initials: F
authors.lastname: Dede
authors.affiliation: Nephrology Department of Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: R
authors.initials: R
authors.lastname: Ozturk
authors.affiliation: Nephrology Department of Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: D
authors.initials: D
authors.lastname: Turgut
authors.affiliation: Nephrology Department of Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Koc
authors.affiliation: Nephrology Department of Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: S V
authors.initials: SV
authors.lastname: Piskinpasa
authors.affiliation: Nephrology Department of Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Ozkayar
authors.affiliation: Nephrology Department of Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: A R
authors.initials: AR
authors.lastname: Odabas
keywords: Diabetes mellitus; non-diabetic renal disease; renal biopsy