title: Exercise improves the effects of testosterone replacement therapy and the durability of response after cessation of treatment: a pilot randomized controlled trial.
abstract: The effects of the combination of exercise and TRT on symptoms of late-onset hypogonadism (LOH) and the durability of response after cessation of TRT were investigated. A total of fifty patients with erectile dysfunction (ED) who had a sedentary lifestyle and low serum total testosterone (T) levels were enrolled and followed for 20 weeks. Patients were randomly divided into two groups; all of them received T gel for 12 weeks and it was discontinued for 8 weeks. Patients assigned to Group II were offered a supervised exercise program for 20 weeks. Measurement of serological testing was performed and self-assessment questionnaires and Global Assessment Question (GAQ) were asked. Baseline characteristics and the initial symptom scores showed no significant difference between the two groups. Serum total T levels and the symptom scores were increased at 12 weeks in both groups, and Group II showed better results with statistical significance. There was a decrease in T levels and worsening of symptom scores at week 20 compared to week 12 in both groups, and Group II showed better results with statistical significance. On the GAQ, Group II showed higher ratio of "yes" at week 12 and the same tendency was sustained at week 20 with significant difference between two groups. The combination of exercise and TRT showed significant improvements in serum T levels and LOH symptoms compared to TRT alone. In addition, these improvements were maintained in the combination group with continuous exercise, even after cessation of TRT.
authors.affiliation: Inje University, Sanggye Paik Hospital, Department of Urology, Seoul, Korea.
authors.forename: Dae-Yeon
authors.initials: DY
authors.lastname: Cho
authors.affiliation: Inje University, Seoul Paik Hospital, Department of Urology, Seoul, Korea.
authors.forename: Jeong Kyun
authors.initials: JK
authors.lastname: Yeo
authors.affiliation: KonKuk University Medical Center, Department of Orthopedics, Seoul, Korea.
authors.forename: Seung Ik
authors.initials: SI
authors.lastname: Cho
authors.affiliation: Inje University, Seoul Paik Hospital, Department of Orthopedics, Sports Medical Center, Seoul, Korea.
authors.forename: Jae Eun
authors.initials: JE
authors.lastname: Jung
authors.affiliation: KonKuk University Medical Center, Department of Orthopedics, Seoul, Korea.
authors.forename: Sang Jin
authors.initials: SJ
authors.lastname: Yang
authors.affiliation: Inje University, Seoul Paik Hospital, Department of Orthopedics, Sports Medical Center, Seoul, Korea.
authors.forename: Doo Hwan
authors.initials: DH
authors.lastname: Kong
authors.affiliation: Inje University, Seoul Paik Hospital, Department of Orthopedics, Sports Medical Center, Seoul, Korea.
authors.forename: Jeong Ku
authors.initials: JK
authors.lastname: Ha
authors.affiliation: KonKuk University Medical Center, Department of Orthopedics, Seoul, Korea.
authors.forename: Jin Goo
authors.initials: JG
authors.lastname: Kim
authors.affiliation: Inje University, Seoul Paik Hospital, Department of Urology, Seoul, Korea.
authors.forename: Min Gu
authors.initials: MG
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D007172:Erectile Dysfunction / Q000188:drug therapy / Q000628:therapy*; D005081:Exercise Therapy; D020249:Hormone Replacement Therapy / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D010865:Pilot Projects; D017430:Prostate-Specific Antigen / Q000097:blood; D013739:Testosterone / Q000097:blood / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D013739:Testosterone; D017430:Prostate-Specific Antigen