title: Association between Sirtuin 1 Gene rs10997870 Polymorphism and Suicide Behaviors in Bipolar Disorder.
abstract: OBJECTIVE
  Suicidal behavior (SB) in bipolar disorder (BD) is a complex multifactorial event resulting from an interaction of genetic, neurobiological and psychosocial factors. Recent studies identified new possible mechanisms, suggesting a role for sirtuins (SIRTs 1-7), a family of nicotinamide adenine dinucleotide-dependent enzymes with a multifaceted role in the central nervous system. The aims of the present study were: (1) to investigate the effects of the rs10997870 SIRT1 gene variant on SB in BD; (2) to explore the effects of the same gene variant on specific depressive symptoms at the severest episode.
  
  
  METHODS
  One hundred and eighty DSM-IV bipolar outpatients were enrolled in a naturalistic cohort study. The rs10997870 polymorphism within the SIRT1 gene was analyzed.
  
  
  RESULTS
  An association between the GG genotype and SB was detected (lifetime: p = 0.015). Compared to other genotypes, GG carriers presented more frequently psychomotor agitation (p = 0.009) and a higher Hamilton Depression Rating Scale total score (p = 0.014) at the severest depressive episode. SB and psychomotor agitation were found to be associated with GG carriers and G allele in a multivariate analysis as well.
  
  
  CONCLUSIONS
  Our findings suggest a role of the rs10997870 SIRT1 gene variant in SB amongst BD patients and its association with specific depressive symptoms. Despite a number of limitations of this exploratory study, our results may provide new insight into the mechanisms underlying SB in BD.
authors.affiliation: Bipolar Disorders Unit, Institute of Neuroscience, Hospital Clínic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Nivoli
authors.forename: Stefano
authors.initials: S
authors.lastname: Porcelli
authors.forename: Diego
authors.initials: D
authors.lastname: Albani
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Forloni
authors.forename: Federica
authors.initials: F
authors.lastname: Fusco
authors.forename: Francesc
authors.initials: F
authors.lastname: Colom
authors.forename: Eduard
authors.initials: E
authors.lastname: Vieta
authors.forename: Alessandro
authors.initials: A
authors.lastname: Serretti
mesh_terms: D000328:Adult; D000483:Alleles; D001714:Bipolar Disorder / Q000235:genetics* / Q000523:psychology; D015331:Cohort Studies; D003863:Depression / Q000235:genetics* / Q000523:psychology; D005260:Female; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011110:Polymorphism, Genetic; D011595:Psychomotor Agitation / Q000235:genetics / Q000523:psychology; D056564:Sirtuin 1 / Q000235:genetics*; D059020:Suicidal Ideation; D013406:Suicide, Attempted
chemical_list: C447939:SIRT1 protein, human; D056564:Sirtuin 1