title: Bis-sesquiterpene from the Marine Sponge Dysidea fragilis.
abstract: Two new sesquiterpenes and one new bis-sesquiterpene, named dysinidins C-E (1-3) along with three known sterols, dysideasterol F, 9α,l lα-epoxycholest-7-en-3β,5α,6α-triol, and 9α,11α-epoxycholest-7-en-3β,5α,6α,19-tetrol 6-acetate (4-6) were isolated from the Vietnamese marine sponge Dysidea fragilis (Montagu, 1814). Their structures were determined by 1D- and 2D-NMR spectroscopies and HR-ESI-MS, as well as by comparison with reported literature data. Compounds 4-6 were found to inhibit eight human cancer cell lines (KB, LU-1, HL-60, LNCaP, SK-Mel-2, HepG-2, MCF-7, and PC-3), with IC50 values ranging from 7.3 to 31.5 µM.
authors.forename: Phan Van
authors.initials: PV
authors.lastname: Kiem
authors.forename: Nguyen Xuan
authors.initials: NX
authors.lastname: Nhiem
authors.forename: Bui Huu
authors.initials: BH
authors.lastname: Tai
authors.forename: Hoang Le Tuan
authors.initials: Hle T
authors.lastname: Anh
authors.forename: Dan Thi Thuy
authors.initials: DT
authors.lastname: Hang
authors.forename: Nguyen Thi
authors.initials: NT
authors.lastname: Cuc
authors.forename: Le Thi
authors.initials: le T
authors.lastname: Huyen
authors.forename: Nguyen Hoai
authors.initials: NH
authors.lastname: Nam
authors.forename: Pham Hai
authors.initials: PH
authors.lastname: Yen
authors.forename: Do Cong
authors.initials: do C
authors.lastname: Thung
authors.forename: Chau Van
authors.initials: CV
authors.lastname: Minh
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification*; D045744:Cell Line, Tumor; D002782:Cholestenes / Q000302:isolation & purification; D004354:Drug Screening Assays, Antitumor; D047088:Dysidea / Q000737:chemistry*; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*; D013261:Sterols / Q000302:isolation & purification
chemical_list: D000970:Antineoplastic Agents; D002782:Cholestenes; D012717:Sesquiterpenes; D013261:Sterols; C575815:dysideasterol F; C000610957:dysinidin C; C000610958:dysinidin D; C000610960:dysinidin E; C059540:9,11-epoxycholest-7-ene-3,5,6-triol