title: Hounsfield unit recovery in clinical cone beam CT images of the thorax acquired for image guided radiation therapy.
abstract: A comprehensive artefact correction method for clinical cone beam CT (CBCT) images acquired for image guided radiation therapy (IGRT) on a commercial system is presented. The method is demonstrated to reduce artefacts and recover CT-like Hounsfield units (HU) in reconstructed CBCT images of five lung cancer patients. Projection image based artefact corrections of image lag, detector scatter, body scatter and beam hardening are described and applied to CBCT images of five lung cancer patients. Image quality is evaluated through visual appearance of the reconstructed images, HU-correspondence with the planning CT images, and total volume HU error. Artefacts are reduced and CT-like HUs are recovered in the artefact corrected CBCT images. Visual inspection confirms that artefacts are indeed suppressed by the proposed method, and the HU root mean square difference between reconstructed CBCTs and the reference CT images are reduced by 31% when using the artefact corrections compared to the standard clinical CBCT reconstruction. A versatile artefact correction method for clinical CBCT images acquired for IGRT has been developed. HU values are recovered in the corrected CBCT images. The proposed method relies on post processing of clinical projection images, and does not require patient specific optimisation. It is thus a powerful tool for image quality improvement of large numbers of CBCT images.
authors.affiliation: Institute of Clinical Research, University of Southern Denmark, Odense, Denmark. Laboratory of Radiation Physics, Odense University Hospital, Odense, Denmark.
authors.forename: Rune Slot
authors.initials: RS
authors.lastname: Thing
authors.forename: Uffe
authors.initials: U
authors.lastname: Bernchou
authors.forename: Ernesto
authors.initials: E
authors.lastname: Mainegra-Hing
authors.forename: Olfred
authors.initials: O
authors.lastname: Hansen
authors.forename: Carsten
authors.initials: C
authors.lastname: Brink
mesh_terms: D016477:Artifacts; D054893:Cone-Beam Computed Tomography / Q000379:methods* / Q000592:standards; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D019047:Phantoms, Imaging; D061089:Radiotherapy, Image-Guided / Q000379:methods* / Q000592:standards; D013909:Thorax / Q000000981:diagnostic imaging