title: The effect of the immune system on ovarian function and features of ovarian germline stem cells.
abstract: In addition to its role in maintaining organism homeostasis, the immune system also plays a crucial role in the modulation of ovarian function, as it regulates ovarian development, follicular maturation, ovulation and the formation of the corpus luteum. Ovarian germline stem cells are pluripotent stem cells derived from the ovarian cortex that can differentiate into ovarian germ cells and primary granulosa cells. Recent work has demonstrated that the proliferation and differentiation of ovarian germline stem cells is regulated in part by immune cells and their secreted factors. This paper reviews the role of the immune system in the regulation of ovarian function, the relationship between immune components and ovarian germline stem cells and current research efforts in this field.
authors.affiliation: Medical Teaching Laboratory Center, Jiangxi Medical College, Nanchang University, Nanchang, China ; The Key Laboratory of Reproductive Physiology and Pathology of Jiangxi Province, Nanchang, China.
authors.forename: Haifeng
authors.initials: H
authors.lastname: Ye
authors.affiliation: Medical Teaching Laboratory Center, Jiangxi Medical College, Nanchang University, Nanchang, China ; The Key Laboratory of Reproductive Physiology and Pathology of Jiangxi Province, Nanchang, China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Li
authors.affiliation: School of the 1st Clinical Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, China.
authors.forename: Tuochen
authors.initials: T
authors.lastname: Zheng
authors.affiliation: Medical Teaching Laboratory Center, Jiangxi Medical College, Nanchang University, Nanchang, China ; The Key Laboratory of Reproductive Physiology and Pathology of Jiangxi Province, Nanchang, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Liang
authors.affiliation: School of Life Science, Nanchang University, Nanchang, China ; Medical Teaching Laboratory Center, Jiangxi Medical College, Nanchang University, Nanchang, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.affiliation: Medical Teaching Laboratory Center, Jiangxi Medical College, Nanchang University, Nanchang, China ; The Key Laboratory of Reproductive Physiology and Pathology of Jiangxi Province, Nanchang, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Huang
authors.affiliation: Medical Teaching Laboratory Center, Jiangxi Medical College, Nanchang University, Nanchang, China ; Faculty of Basic Medical Science, Jiangxi Medical College, Nanchang University, Nanchang, China.
authors.forename: Zezheng
authors.initials: Z
authors.lastname: Pan
authors.affiliation: School of Life Science, Nanchang University, Nanchang, China ; Medical Teaching Laboratory Center, Jiangxi Medical College, Nanchang University, Nanchang, China.
authors.forename: Yuehui
authors.initials: Y
authors.lastname: Zheng
keywords: Immune system; Ovarian function; Ovarian germline stem cells