title: FDG-PET hyperactivity pattern in anti-NMDAr encephalitis.
abstract: FDG-PET can show anteroposterior glucose metabolism gradient in anti-NMDAr encephalitis, but there are also suggestions that basal ganglia are involved. We examined FDG-PET scans in 5 consecutive episodes of serologically proven anti-NMDAr encephalitis, compared with healthy controls. We confirmed the anteroposterior metabolic gradient and found a significant FDG uptake increase in the caudate nuclei in episodes of varying intensity and delay from the onset of the symptoms. FDG-PET can be useful in the work-up of suspected anti-NMDAr encephalitis disclosing a characteristic cortical and sub-cortical metabolism pattern.
authors.affiliation: Neurology service, Department of clinical neurosciences, CHUV, University of Lausanne, Lausanne, Switzerland. Electronic address: jan.novy@chuv.ch.
authors.forename: Jan
authors.initials: J
authors.lastname: Novy
authors.affiliation: Nuclear Medicine, CHUV, University of Lausanne, Lausanne, Switzerland.
authors.forename: Gilles
authors.initials: G
authors.lastname: Allenbach
authors.affiliation: Department of Epileptology, University of Bonn, Bonn, Germany; Epilepsy Centre Bethel, Mara Hospital, Bielefeld, Germany.
authors.forename: Christian G
authors.initials: CG
authors.lastname: Bien
authors.affiliation: Service Central de Biophysique et Médecine Nucléaire, CHU Timone & Centre Européen de Recherche en Imagerie Médicale, CERIMED & Centre d'Investigation Clinique, CIC, INSERM, Université de la Méditerranée, Marseille F-13000, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Guedj
authors.affiliation: Nuclear Medicine, CHUV, University of Lausanne, Lausanne, Switzerland.
authors.forename: John O
authors.initials: JO
authors.lastname: Prior
authors.affiliation: Neurology service, Department of clinical neurosciences, CHUV, University of Lausanne, Lausanne, Switzerland.
authors.forename: Andrea O
authors.initials: AO
authors.lastname: Rossetti
mesh_terms: D000328:Adult; D060426:Anti-N-Methyl-D-Aspartate Receptor Encephalitis / Q000000981:diagnostic imaging* / Q000378:metabolism*; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism*; D006801:Humans; D049268:Positron-Emission Tomography; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: Inflammation; NMDA; Psychiatry