title: Effect of Patient Sex on the Severity of Coronary Artery Disease in Patients with Newly Diagnosis of Obstructive Sleep Apnoea Admitted by an Acute Coronary Syndrome.
abstract: BACKGROUND
  The cardiovascular consequences of obstructive sleep apnoea (OSA) differ by sex. We hypothesized that sex influences the severity of acute coronary syndrome (ACS) in patients with OSA. OSA was defined as an apnoea-hypopnoea index (AHI)>15 events·h-1. We evaluated the severity of ACS according to the ejection fraction, Killip class, number of diseased vessels, number of stents implanted and plasma peak troponin level.
  
  
  METHODS
  We included 663 men (mean±SD, AHI 37±18 events·h-1) and 133 women (AHI 35±18 events·h-1) with OSA.
  
  
  RESULTS
  The men were younger than the women (59±11 versus 66±11 years, p<0.0001), exhibited a higher neck circumference (p<0.0001), and were more likely to be smokers and alcohol users than women (p<0.0001, p = 0.0005, respectively). Body mass index and percentage of hypertensive patients or diabetics were similar between sexes. We observed a slight tendency for a higher Killip classification in women, although it was not statistically significant (p = 0.055). For men, we observed that the number of diseased vessels and the number of stents implanted were higher (p = 0.02, p = 0.001, respectively), and a decrease in the ejection fraction (p = 0.002).
  
  
  CONCLUSIONS
  This study shows that sex in OSA influences the severity of ACS. Men show a lower ejection fraction and an increased number of diseased vessels and number of stents implanted.
authors.affiliation: Respiratory Department. Group of Translational Research in Respiratory Medicine. Hospital Universitari Arnau de Vilanova and Santa Maria. IRBLleida. Lleida, Catalonia, Spain.|Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES). Madrid, Spain.
authors.forename: Alicia
authors.initials: A
authors.lastname: Sánchez-de-la-Torre
authors.affiliation: Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES). Madrid, Spain.|Respiratory Department, Hosp Universitari Germans Trias I Pujol, Badalona, Barcelona, Catalonia, Spain.
authors.forename: Jorge
authors.initials: J
authors.lastname: Abad
authors.affiliation: Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES). Madrid, Spain.|Bio-Araba Research Institute, Araba University Hospital. Department of Medicine of Basque Country University, Vitoria-Gasteiz Spain.
authors.forename: Joaquín
authors.initials: J
authors.lastname: Durán-Cantolla
authors.affiliation: Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES). Madrid, Spain.|Respiratory Department, Hospital Universitario de Guadalajara. Guadalajara, Spain.
authors.forename: Olga
authors.initials: O
authors.lastname: Mediano
authors.affiliation: Respiratory Department, Hospital Universitario Cruces. Bilbao, Spain.
authors.forename: Valentín
authors.initials: V
authors.lastname: Cabriada
authors.affiliation: Respiratory Department, Hospital Parc Tauli. Sabadell, Barcelona, Catalonia. Spain.
authors.forename: María José
authors.initials: MJ
authors.lastname: Masdeu
authors.affiliation: Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES). Madrid, Spain.|Respiratory Department, Hospital General Yagüe. Burgos, Spain.
authors.forename: Joaquín
authors.initials: J
authors.lastname: Terán
authors.affiliation: Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES). Madrid, Spain.|Respiratory Department, Hospital San Pedro Alcántara, Cáceres, Spain.
authors.forename: Juan Fernando
authors.initials: JF
authors.lastname: Masa
authors.affiliation: Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES). Madrid, Spain.|Clinic Analysis and Respiratory Services, Hospital Universitari Son Espases, Institut de investigació sanitaria de Palma (IdisPa), Palma de Mallorca, Spain.
authors.forename: Mónica
authors.initials: M
authors.lastname: de la Peña
authors.affiliation: Cardiology Department, Hospital Universitari Arnau de Vilanova. IRBLleida, Lleida, Catalonia, Spain.
authors.forename: Albina
authors.initials: A
authors.lastname: Aldomá
authors.affiliation: Cardiology Department, Hospital Universitari Arnau de Vilanova. IRBLleida, Lleida, Catalonia, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Worner
authors.affiliation: Department of Statistics. IRB Lleida, Lleida, Catalonia, Spain.
authors.forename: Joan
authors.initials: J
authors.lastname: Valls
authors.affiliation: Respiratory Department. Group of Translational Research in Respiratory Medicine. Hospital Universitari Arnau de Vilanova and Santa Maria. IRBLleida. Lleida, Catalonia, Spain.|Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES). Madrid, Spain.
authors.forename: Ferran
authors.initials: F
authors.lastname: Barbé
authors.affiliation: Respiratory Department. Group of Translational Research in Respiratory Medicine. Hospital Universitari Arnau de Vilanova and Santa Maria. IRBLleida. Lleida, Catalonia, Spain.|Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES). Madrid, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Sánchez-de-la-Torre
mesh_terms: D054058:Acute Coronary Syndrome / Q000150:complications* / Q000209:etiology / Q000503:physiopathology; D000368:Aged; D045422:Continuous Positive Airway Pressure; D003324:Coronary Artery Disease / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D012727:Sex Characteristics; D020181:Sleep Apnea, Obstructive / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D015607:Stents; D013318:Stroke Volume; D014336:Troponin / Q000097:blood
chemical_list: D014336:Troponin