title: Co-opting Moore's law: Therapeutics, vaccines and interfacially active particles manufactured via PRINT®.
abstract: Nanoparticle properties such as size, shape, deformability, and surface chemistry all play a role in nanomedicine drug delivery. While many studies address the behavior of particle systems in a biological setting, revealing how these properties work together presents unique challenges on the nanoscale. Particle replication in non-wetting templates (PRINT®) is one molding technique that allows for fabrication of "calibration quality" micro and nanoparticles with independent control over their physical parameters. As the only technology in the world capable of independently optimizing and robustly manufacturing GMP compliant precision particles of virtually any size, shape, and composition, the PRINT technology has the capability to engineer the future of healthcare.
authors.affiliation: Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, Lineberger Comprehensive Cancer Center, Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Chemical and Biomolecular Engineering, NC State University, Raleigh, NC 27695, USA; Sloan-Kettering Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. Electronic address: desimone@email.unc.edu.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: DeSimone
mesh_terms: D004337:Drug Carriers / Q000737:chemistry*; D050997:Nanomedicine / Q000295:instrumentation / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D013499:Surface Properties; D013678:Technology, Pharmaceutical / Q000295:instrumentation / Q000379:methods*; D014612:Vaccines / Q000008:administration & dosage*
chemical_list: D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D014612:Vaccines
keywords: Calibration quality particles; Clinical trials; Drug delivery vehicle; Liquidia technologies; Nanoparticle; PRINT; Particle engineering; Particulate vaccine; Team-based science; cGMP delivery vehicle