title: Flow Chemistry on Multigram Scale: Continuous Synthesis of Boronic Acids within 1 s.
abstract: The benefits and limitations of a simple continuous flow setup for handling and performing of organolithium chemistry on the multigram scale is described. The developed metalation platform embodies a valuable complement to existing methodologies, as it combines the benefits of Flash Chemistry (chemical synthesis on a time scale of <1 s) with remarkable throughput (g/min) while mitigating the risk of blockages.
authors.affiliation: Novartis Campus, Novartis Pharma AG, 4002 Basel, Switzerland.
authors.forename: Andreas
authors.initials: A
authors.lastname: Hafner
authors.affiliation: Novartis Campus, Novartis Pharma AG, 4002 Basel, Switzerland.
authors.forename: Mark
authors.initials: M
authors.lastname: Meisenbach
authors.affiliation: Novartis Campus, Novartis Pharma AG, 4002 Basel, Switzerland.
authors.forename: Joerg
authors.initials: J
authors.lastname: Sedelmeier