title: An NMF-L2,1-Norm Constraint Method for Characteristic Gene Selection.
abstract: Recent research has demonstrated that characteristic gene selection based on gene expression data remains faced with considerable challenges. This is primarily because gene expression data are typically high dimensional, negative, non-sparse and noisy. However, existing methods for data analysis are able to cope with only some of these challenges. In this paper, we address all of these challenges with a unified method: nonnegative matrix factorization via the L2,1-norm (NMF-L2,1). While L2,1-norm minimization is applied to both the error function and the regularization term, our method is robust to outliers and noise in the data and generates sparse results. The application of our method to plant and tumor gene expression data demonstrates that NMF-L2,1 can extract more characteristic genes than other existing state-of-the-art methods.
authors.affiliation: School of Information Science and Engineering, Qufu Normal University, Rizhao, 276826, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
authors.affiliation: School of Information Science and Engineering, Qufu Normal University, Rizhao, 276826, China.|Bio-Computing Research Center, Shenzhen Graduate School, Harbin Institute of Technology, Shenzhen, 518055, China.
authors.forename: Jin-Xing
authors.initials: JX
authors.lastname: Liu
authors.affiliation: Library of Qufu Normal University, Qufu Normal University, Rizhao, 276826, China.
authors.forename: Ying-Lian
authors.initials: YL
authors.lastname: Gao
authors.affiliation: School of Information Science and Engineering, Qufu Normal University, Rizhao, 276826, China.
authors.forename: Jiguo
authors.initials: J
authors.lastname: Yu
authors.affiliation: School of Information Science and Engineering, Qufu Normal University, Rizhao, 276826, China.
authors.forename: Chun-Hou
authors.initials: CH
authors.lastname: Zheng
authors.affiliation: Bio-Computing Research Center, Shenzhen Graduate School, Harbin Institute of Technology, Shenzhen, 518055, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Xu
mesh_terms: D000465:Algorithms; D030541:Databases, Genetic; D005163:Factor Analysis, Statistical; D015870:Gene Expression; D015972:Gene Expression Regulation, Neoplastic; D018506:Gene Expression Regulation, Plant; D063990:Gene Ontology; D023281:Genomics / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000235:genetics; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D010944:Plants / Q000235:genetics; D012641:Selection, Genetic