title: Imaging features of medicine-related osteonecrosis of the jaws: comparison between panoramic radiography and computed tomography.
abstract: OBJECTIVE
  The current staging system of medicine-related osteonecrosis of the jaws (MRONJ) assigns patients to different stages based on clinical manifestations. The extent of bone disease cannot be fully determined without radiologic evaluation. Missing radiologic information may lead to incorrect classification of MRONJ, resulting in poor outcomes of treatment. The objective of this study was to compare computed tomography (CT) and panoramic radiography (PR) features of MRONJ in different stages to achieve accurate staging on the basis of combined findings from clinical staging and imaging.
  
  
  METHODS
  A retrospective study was carried out to analyze the differences in the radiographic features of various clinical stages in MRONJ, as shown by PR and CT.
  
  
  RESULTS
  Both PR and CT could detect the typical syndrome of osseous sclerosis in grade 0 and grade 1. For the patients of grade 2, more features were observed on CT, such as periosteal reaction, cortical perforation, and periosteal bone deposition. CT was also conducive to analyzing the degree of the maxillary lesion and soft tissue involvement as compared with PR.
  
  
  CONCLUSIONS
  This study showed that CT detects changes that may not be revealed by plain radiography in patients with MRONJ.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, China.
authors.forename: Yuxing
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, China.
authors.forename: Diancan
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Peng
authors.affiliation: Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, China. Electronic address: Chuanbinguo@126.com.
authors.forename: Chuanbin
authors.initials: C
authors.lastname: Guo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011862:Radiography, Panoramic; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed