title: Physicians' perspectives regarding pragmatic clinical trials.
abstract: Practicing physicians inevitably become involved in pragmatic clinical trials (PCTs), including comparative effectiveness research. We sought to identify physicians' perspectives related to PCTs.
  
  
  
  In-depth semistructured interviews with 20 physicians in the USA.
  
  
  
  Although physicians are generally willing to participate in PCTs, their support is predicated on several factors including expected benefits, minimization of time and workflow burdens and physician engagement. Physicians communicated a desire to respect patients' rights and interests while maintaining a high level of care.
  
  
  
  Future work is needed to systematically assess the impact of PCTs on clinicians in meeting their ethical obligations to patients and the burdens clinicians are willing to accept in exchange for potential benefits.
authors.affiliation: Berman Institute of Bioethics, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Rachel
authors.initials: R
authors.lastname: Topazian
authors.affiliation: Berman Institute of Bioethics, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Juli
authors.initials: J
authors.lastname: Bollinger
authors.affiliation: Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA.|Department of Psychiatry & Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA.
authors.forename: Kevin P
authors.initials: KP
authors.lastname: Weinfurt
authors.affiliation: Berman Institute of Bioethics, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Rachel
authors.initials: R
authors.lastname: Dvoskin
authors.affiliation: Berman Institute of Bioethics, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Debra
authors.initials: D
authors.lastname: Mathews
authors.affiliation: Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA.
authors.forename: Kathleen
authors.initials: K
authors.lastname: Brelsford
authors.affiliation: Berman Institute of Bioethics, Johns Hopkins University, Baltimore, MD, USA.|Division of General Internal Medicine, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: DeCamp
authors.affiliation: Berman Institute of Bioethics, Johns Hopkins University, Baltimore, MD, USA.|Division of General Internal Medicine, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.|Department of Health Policy & Management, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Jeremy
authors.initials: J
authors.lastname: Sugarman
mesh_terms: D001291:Attitude of Health Personnel; D057186:Comparative Effectiveness Research; D006801:Humans; D010820:Physicians; D064792:Pragmatic Clinical Trials as Topic
keywords: comparative effectiveness research; ethics; qualitative research