title: The effect of resistance training on clinical outcomes in heart failure: A systematic review and meta-analysis.
abstract: OBJECTIVE
  To quantify the change in effect sizes, for selected clinical outcome measures, in people with heart failure, from resistance exercise, either in isolation, or in combination with aerobic training.
  
  
  BACKGROUND
  Most exercise training data in heart failure, relates to aerobic exercise, we sought to provide current evidence for the benefits of resistance training in this population.
  
  
  METHODS
  We conducted a MEDLINE search (1985 to May 1, 2016), for exercise based rehabilitation trials in heart failure, using search terms 'resistance training, combined training, left ventricular dysfunction, peak VO2, cardio-myopathy and systolic heart dysfunction'.
  
  
  RESULTS
  The 27 included studies provided a total of 2321 participants, 1172 in an intervention and 1149 in either sedentary controls or aerobic exercise only groups, producing over 31,263 patient-hours of training. Mortality, hospitalization, resting blood pressure and Left ventricular fraction were all unchanged with resistance or combined aerobic and resistance training. Peak VO2 was improved in combined exercise vs. control MD of 1.43ml·kg(-1)·min(-1) (95% CI 0.63, 2.23, p=0.0004; and in resistance vs. control MD 3.99ml·kg(-1)·min(-1) (95% CI 1.47, 6.51, p=0.002). Quality of Life (MLwHFQ) was improved in combined vs. control MD -8.31 (95% CI -14.3, -2.33, p=0.006). Six-minute walk distance was improved combined exercise vs. control, MD 13.49m (95% CI 1.13, 25.84, p=0.03); and resistance vs. control MD 41.77m (95% CI 21.90, 61.64, p<0.0001): SMD 1.25 (95%CI 0.53, 1.98, p=0.0007).
  
  
  CONCLUSIONS
  Resistance only or combined training improves peak VO2, quality of life and walking performance in heart failure patients.
authors.affiliation: Schools of Rural Medicine, University of New England, Armidale, NSW 2351, Australia; Science and Technology, University of New England, Armidale, NSW 2351, Australia.
authors.forename: D
authors.initials: D
authors.lastname: Jewiss
authors.affiliation: Schools of Rural Medicine, University of New England, Armidale, NSW 2351, Australia; Science and Technology, University of New England, Armidale, NSW 2351, Australia.
authors.forename: C
authors.initials: C
authors.lastname: Ostman
authors.affiliation: Schools of Rural Medicine, University of New England, Armidale, NSW 2351, Australia; Science and Technology, University of New England, Armidale, NSW 2351, Australia. Electronic address: nsmart2@une.edu.au.
authors.forename: N A
authors.initials: NA
authors.lastname: Smart
mesh_terms: D015444:Exercise / Q000502:physiology* / Q000523:psychology; D006333:Heart Failure / Q000175:diagnosis* / Q000523:psychology / Q000628:therapy*; D006760:Hospitalization / Q000639:trends; D006801:Humans; D009026:Mortality / Q000639:trends; D016032:Randomized Controlled Trials as Topic / Q000379:methods; D055070:Resistance Training / Q000379:methods / Q000639:trends*; D016896:Treatment Outcome; D016138:Walking / Q000502:physiology / Q000523:psychology
keywords: Combined training; Heart failure; Resistance training