title: Secondary hemophagocytic lymphohistiocytosis induced by cholecystitis: A case report and a review of the literature.
abstract: BACKGROUND
  Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening disease resulting from excessive activation and non-malignant proliferation of macrophages and T lymphocytes. Whether it can be caused by cholecystitis has not yet been reported in the world.
  
  
  METHODS
  A 4-year-old girl was admitted to hospital with cholecystitis. The patient was diagnosed with hemophagocytic lymphohistiocytosis after 3days of admission based on the results of laboratory tests showing hypofibrinogenemia, hypertriglyceridemia, thrombocytopenia, anemia and leukopenia.
  
  
  CONCLUSIONS
  From this case experience, if a timely symptomatic treatment is given, the condition of the patient with secondary HLH can be alleviated. This is the first report of cholecystitis-induced hemophagocytic syndrome in the world also.
authors.affiliation: Analytical Section of Attached Hospital of Jining Medical College, Jining City, Shandong Province, PR China.
authors.forename: Cheng-Qiang
authors.initials: CQ
authors.lastname: Jin
authors.affiliation: Analytical Section of Attached Hospital of Jining Medical College, Jining City, Shandong Province, PR China.
authors.forename: Hai-Xin
authors.initials: HX
authors.lastname: Dong
authors.affiliation: Analytical Section of Attached Hospital of Jining Medical College, Jining City, Shandong Province, PR China.
authors.forename: Jian-Wei
authors.initials: JW
authors.lastname: Zhou
authors.affiliation: Radiology Department, Jining NO.1 People's Hospital, Shandong Province, PR China. Electronic address: jincq2008@163.com.
authors.forename: Yan-Xia
authors.initials: YX
authors.lastname: Jia
mesh_terms: D002675:Child, Preschool; D002764:Cholecystitis / Q000150:complications*; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control; D013997:Time Factors
keywords: Anemia; Cholecystitis; Hemophagocytic lymphohistiocytosis; Hemophagocytic syndrome