title: Mismatch Negativity Recording in Children With Duchenne Muscular Dystrophy: A Preliminary Study Integrating Neurophysiological and Neuropsychological Results.
abstract: Many studies on Duchenne muscular dystrophy children support the hypothesis of a specific neuropsychological phenotype affecting mostly phonological skills. This prospective study aimed to shed light on the role of phonological abilities. Fourteen Duchenne muscular dystrophy children and 7 healthy children underwent mismatch negativity. Moreover, verbal intelligence, visuospatial attention, immediate verbal memory, working memory, grammar, vocabulary, visuomotor skills, reading, text comprehension, writing, and arithmetic were tested in Duchenne muscular dystrophy children. No significant difference between control and Duchenne muscular dystrophy children was found neither for mismatch negativity amplitude (P = .191 and .116, respectively) nor for latency (P = .135). Eight (57.14%) patients showed an impairment of immediate verbal memory and of visuomotor skills, 7 (63.64%) patients had a deficit in writing and arithmetic skills, even with a mean normal intelligence quotient. Taken together, the results put in evidence a heterogeneous neuropsychological profile not explainable on the basis of a phonological deficit.
authors.affiliation: Child Neurology Unit, IRCCS Istituto delle Scienze Neurologiche, Bologna, Italy melissa.filippini@libero.it.
authors.forename: Melissa
authors.initials: M
authors.lastname: Filippini
authors.affiliation: Child Neurology Unit, IRCCS Istituto delle Scienze Neurologiche, Bologna, Italy.
authors.forename: Angelo
authors.initials: A
authors.lastname: Guerra
authors.affiliation: Child Neurology Unit, IRCCS Istituto delle Scienze Neurologiche, Bologna, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Negosanti
authors.affiliation: Child Neurology Unit, IRCCS Istituto delle Scienze Neurologiche, Bologna, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Santi
authors.affiliation: Child Neurology Unit, IRCCS Istituto delle Scienze Neurologiche, Bologna, Italy.
authors.forename: Jasenka
authors.initials: J
authors.lastname: Sarajlija
authors.affiliation: Department of Public Health, Local Health Authority of Bologna, Bologna, Italy.
authors.forename: Muriel Assunta
authors.initials: MA
authors.lastname: Musti
authors.affiliation: Child Neurology Unit, IRCCS Istituto delle Scienze Neurologiche, Bologna, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Gobbi
authors.affiliation: Department of Psychology, Université de Montréal, Montréal, Canada.
authors.forename: Maryse
authors.initials: M
authors.lastname: Lassonde
authors.affiliation: Child Neurology Unit, IRCCS Istituto delle Scienze Neurologiche, Bologna, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Pini
mesh_terms: D000293:Adolescent; D001921:Brain / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D006801:Humans; D008297:Male; D008959:Models, Neurological; D008960:Models, Psychological; D020388:Muscular Dystrophy, Duchenne / Q000503:physiopathology* / Q000523:psychology*; D009483:Neuropsychological Tests; D011446:Prospective Studies; D013067:Speech Perception / Q000502:physiology*
keywords: Duchenne muscular dystrophy; cerebellar hypothesis; mismatch negativity; neuropsychological profile; phonological hypothesis