title: ASSOCIATION OF EPSTEIN-BARR VIRUS (EBV) BUT NOT HUMAN PAPILLOMAVIRUS (HPV) WITH GINGIVITIS AND/OR PERIODONTITIS IN TRANSPLANTED INDIVIDUALS.
abstract: The aim of this study was to investigate the association of EBV and HPV with gingivitis and/or periodontitis according to the immunologic status. To this end, 74 oral biopsies from transplanted and non-transplanted individuals with the abovementioned oral manifestations were submitted to a screening by PCR for both viruses. According to the results, EBV was strongly associated with gingivitis and/or periodontitis in transplanted individuals (p = 0.011) but not HPV (p = 0.766). EBV-HPV co-detections did not enhance the presence of tissue injury as well. Although a causal relationship was not investigated in this study, the higher frequency of these two oncoviruses in lesion tissues must be investigated in follow-up studies, especially among immunocompromised individuals.
authors.affiliation: Universidade Federal do Rio do Janeiro, Department of Preventive Medicine, Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brazil.
authors.forename: Camila Freze
authors.initials: CF
authors.lastname: Baez
authors.affiliation: Universidade Federal Fluminense, Department of Microbiology and Parasitology. Niterói, RJ, Brazil.
authors.forename: Flavia
authors.initials: F
authors.lastname: Savassi-Ribas
authors.affiliation: Universidade Federal Fluminense, Department of Microbiology and Parasitology. Niterói, RJ, Brazil.
authors.forename: Wilker Menezes da
authors.initials: WM
authors.lastname: Rocha
authors.affiliation: Universidade Federal Fluminense, Department of Microbiology and Parasitology. Niterói, RJ, Brazil.
authors.forename: Stéphanie G S
authors.initials: SG
authors.lastname: Almeida
authors.affiliation: Universidade Federal Fluminense, Department of Microbiology and Parasitology. Niterói, RJ, Brazil.
authors.forename: Marianna T V
authors.initials: MT
authors.lastname: Gonçalves
authors.affiliation: Universidade Federal do Rio do Janeiro, Department of Preventive Medicine, Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brazil.
authors.forename: Maria Angelica A M
authors.initials: MA
authors.lastname: Guimarães
authors.affiliation: Universidade Federal Fluminense, Department of Microbiology and Parasitology. Niterói, RJ, Brazil.
authors.forename: Silvia Maria B
authors.initials: SM
authors.lastname: Cavalcanti
authors.affiliation: Universidade Federal Fluminense, Department of Microbiology and Parasitology. Niterói, RJ, Brazil.
authors.forename: Rafael B
authors.initials: RB
authors.lastname: Varella
mesh_terms: D016022:Case-Control Studies; D004279:DNA, Viral / Q000235:genetics; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis*; D005891:Gingivitis / Q000175:diagnosis / Q000821:virology*; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D016030:Kidney Transplantation; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000175:diagnosis*; D010518:Periodontitis / Q000175:diagnosis / Q000821:virology*; D016133:Polymerase Chain Reaction
chemical_list: D004279:DNA, Viral