title: Genetic inactivation of calpain-1 attenuates pain sensitivity in a humanized mouse model of sickle cell disease.
authors.affiliation: Graduate Program in Pharmacology and Experimental Therapeutics, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA.
authors.forename: Jennifer O
authors.initials: JO
authors.lastname: Nwankwo
authors.affiliation: Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN.
authors.forename: Jianxun
authors.initials: J
authors.lastname: Lei
authors.affiliation: Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX.
authors.forename: Jian
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Laboratory Medicine, Boston Children's Hospital and Department of Pathology, Harvard Medical School, Boston, MA.
authors.forename: Alicia
authors.initials: A
authors.lastname: Rivera
authors.affiliation: Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN.
authors.forename: Kalpna
authors.initials: K
authors.lastname: Gupta
authors.affiliation: Graduate Program in Pharmacology and Experimental Therapeutics, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA, USA athar.chishti@tufts.edu.
authors.forename: Athar H
authors.initials: AH
authors.lastname: Chishti
mesh_terms: D000755:Anemia, Sickle Cell / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D000818:Animals; D002154:Calpain / Q000172:deficiency / Q000235:genetics*; D004195:Disease Models, Animal; D017353:Gene Deletion; D020868:Gene Silencing / Q000502:physiology*; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D010146:Pain / Q000235:genetics* / Q000378:metabolism / Q000517:prevention & control*
chemical_list: D002154:Calpain; C112682:Capn1 protein, mouse
keywords: calpain-1; genetic inactivation; humanized mouse model; pain; sickle cell disease