title: IFNs-signaling effects on lung cancer: an up-to-date pathways-specific review.
abstract: IFNs have found important applications in clinical medicine, including the treatment of lung malignancies. The biological effect of the IFN-receptor signaling is regulated essentially by three factors: the expression profile of the IFN itself, the profile of the receptor, and the expression of target genes. IFNs initiate their signaling by binding to specific receptors. The activated IFNs can directly induce gene transcription and/or multiple downstream signaling that both induce diverse cellular responses including the cell cycle arrest and the apoptosis in tumor cells. We provided evidence that IFN-γ enhances the pro cell death effects of Fas/CD95 in human neoplastic alveolar epithelial cell line, A549. We also found that p27 protein plays a pivotal role in the inducing cell death of IFNγ-CH-11-treated A549 cells, since it is involved in the Ras/Raf signaling pathway. This article discusses recent insights into these possible additional functions of IFNs in lung cancer treatment.
authors.affiliation: Department of Anatomy-Histology-Embryology, Faculty of Medicine, University of Ioannina, 45110, Ioannina, Greece. vgalani@cc.uoi.gr.
authors.forename: Vasiliki
authors.initials: V
authors.lastname: Galani
authors.affiliation: Department of Anatomy-Histology-Embryology, Faculty of Medicine, University of Ioannina, 45110, Ioannina, Greece.
authors.forename: Michalis
authors.initials: M
authors.lastname: Kastamoulas
authors.affiliation: Department of Ippokratio Hospital, Thessaloníki, Greece.
authors.forename: Anna
authors.initials: A
authors.lastname: Varouktsi
authors.affiliation: Department of Cancer Biobank Center, University of Ioannina, Ioannina, Greece.
authors.forename: Evangeli
authors.initials: E
authors.lastname: Lampri
authors.affiliation: Department of Forensic Pathology, Faculty of Medicine, University of Ioannina, Ioannina, Greece.
authors.forename: Antigoni
authors.initials: A
authors.lastname: Mitselou
authors.affiliation: Department of Anatomy-Histology-Embryology, Faculty of Medicine, University of Thessaly, Larissa, Greece.
authors.forename: Dimitrios L
authors.initials: DL
authors.lastname: Arvanitis
mesh_terms: D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology* / Q000627:therapeutic use*; D007372:Interferons / Q000494:pharmacology* / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000188:drug therapy*; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D007155:Immunologic Factors; D007372:Interferons
keywords: IFNs-receptors; IFNs-signaling; Lung cancer; Profile IFNs