title: Randomized Phase III Trial of Irinotecan Plus Cisplatin Compared With Paclitaxel Plus Carboplatin As First-Line Chemotherapy for Ovarian Clear Cell Carcinoma: JGOG3017/GCIG Trial.
abstract: Clear cell carcinoma (CCC) is a rare histologic subtype that demonstrates poor outcomes in epithelial ovarian cancer. The Japanese Gynecologic Oncology Group conducted the first randomized phase III, CCC-specific clinical trial that compared irinotecan and cisplatin (CPT-P) with paclitaxel plus carboplatin (TC) in patients with CCC.
  
  
  
  Six hundred sixty-seven patients with stage I to IV CCC of the ovary were randomly assigned to receive irinotecan 60 mg/m(2) on days 1, 8, and 15 plus cisplatin 60 mg/m(2) on day 1 (CPT-P group) every 4 weeks for six cycles or paclitaxel 175 mg/m(2) plus carboplatin area under the curve 6.0 mg/mL/min on day 1 every 3 weeks for six cycles (TC group). The primary end point was progression-free survival. Secondary end points were overall survival, overall response rate, and adverse events.
  
  
  
  Six hundred nineteen patients were clinically and pathologically eligible for evaluation. With a median follow-up of 44.3 months, 2-year progression-free survival rates were 73.0% in the CPT-P group and 77.6% in TC group (hazard ratio, 1.17; 95% CI, 0.87 to 1.58; P = .85). Two-year overall survival rates were 85.5% with CPT-P and 87.4% with TC (hazard ratio, 1.13; 95% CI, 0.80 to 1.61; one-sided P = .76). Grade 3/4 anorexia, diarrhea, nausea, vomiting, and febrile neutropenia occurred more frequently with CPT-P, whereas grade 3/4 leukopenia, neutropenia, thrombocytopenia, peripheral sensory neuropathy, and joint pain occurred more frequently with TC.
  
  
  
  No significant survival benefit was found for CPT-P. Both regimens were well tolerated, but the toxicity profiles differed significantly. Treatment with existing anticancer agents has limitations to improving the prognosis of CCC.
authors.affiliation: Toru Sugiyama, Iwate Medical University, Iwate; Aikou Okamoto, Hiroshi Tanabe, and Seiji Isonishi, The Jikei University School of Medicine; Tetsutaro Hamano, Kitasato University; Yasuhisa Terao, Juntendo University; Mikio Mikami, Tokai University; Hiroyuki Nomura and Daisuke Aoki, Keio University; Fumitoshi Terauchi, Tokyo Medical University, Tokyo; Takayuki Enomoto and Koji Nishino, Niigata University, Niigata; Eriko Aotani, Kanagawa Academy of Science and Technology; Nao Suzuki, St Marianna University, Kanagawa; Nobuo Yaegashi, Tohoku University, Miyagi; Kiyoko Kato, Kyushu University, Fukuoka; Hiroyuki Yoshikawa, University of Tsukuba, Ibaraki; Yoshihito Yokoyama, Hirosaki University, Aomori; Keiichi Fujiwara, Saitama Medical University International Medical Center, Saitama, Japan; Jae-Weon Kim, Seoul National University; Byoung-Gie Kim, Sungkyunkwan University, Seoul, South Korea; Sandro Pignata, Istituto Nazionale Tumori di Napoli, Naples, Italy; Jerome Alexandre, Hôpital Hôtel-Dieu, Montreal, Quebec, Canada; and John Green, University of Liverpool, Liverpool, United Kingdom.
authors.forename: Toru
authors.initials: T
authors.lastname: Sugiyama
authors.affiliation: Toru Sugiyama, Iwate Medical University, Iwate; Aikou Okamoto, Hiroshi Tanabe, and Seiji Isonishi, The Jikei University School of Medicine; Tetsutaro Hamano, Kitasato University; Yasuhisa Terao, Juntendo University; Mikio Mikami, Tokai University; Hiroyuki Nomura and Daisuke Aoki, Keio University; Fumitoshi Terauchi, Tokyo Medical University, Tokyo; Takayuki Enomoto and Koji Nishino, Niigata University, Niigata; Eriko Aotani, Kanagawa Academy of Science and Technology; Nao Suzuki, St Marianna University, Kanagawa; Nobuo Yaegashi, Tohoku University, Miyagi; Kiyoko Kato, Kyushu University, Fukuoka; Hiroyuki Yoshikawa, University of Tsukuba, Ibaraki; Yoshihito Yokoyama, Hirosaki University, Aomori; Keiichi Fujiwara, Saitama Medical University International Medical Center, Saitama, Japan; Jae-Weon Kim, Seoul National University; Byoung-Gie Kim, Sungkyunkwan University, Seoul, South Korea; Sandro Pignata, Istituto Nazionale Tumori di Napoli, Naples, Italy; Jerome Alexandre, Hôpital Hôtel-Dieu, Montreal, Quebec, Canada; and John Green, University of Liverpool, Liverpool, United Kingdom. aikou@jikei.ac.jp.
authors.forename: Aikou
authors.initials: A
authors.lastname: Okamoto
authors.affiliation: Toru Sugiyama, Iwate Medical University, Iwate; Aikou Okamoto, Hiroshi Tanabe, and Seiji Isonishi, The Jikei University School of Medicine; Tetsutaro Hamano, Kitasato University; Yasuhisa Terao, Juntendo University; Mikio Mikami, Tokai University; Hiroyuki Nomura and Daisuke Aoki, Keio University; Fumitoshi Terauchi, Tokyo Medical University, Tokyo; Takayuki Enomoto and Koji Nishino, Niigata University, Niigata; Eriko Aotani, Kanagawa Academy of Science and Technology; Nao Suzuki, St Marianna University, Kanagawa; Nobuo Yaegashi, Tohoku University, Miyagi; Kiyoko Kato, Kyushu University, Fukuoka; Hiroyuki Yoshikawa, University of Tsukuba, Ibaraki; Yoshihito Yokoyama, Hirosaki University, Aomori; Keiichi Fujiwara, Saitama Medical University International Medical Center, Saitama, Japan; Jae-Weon Kim, Seoul National University; Byoung-Gie Kim, Sungkyunkwan University, Seoul, South Korea; Sandro Pignata, Istituto Nazionale Tumori di Napoli, Naples, Italy; Jerome Alexandre, Hôpital Hôtel-Dieu, Montreal, Quebec, Canada; and John Green, University of Liverpool, Liverpool, United Kingdom.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Enomoto
authors.affiliation: Toru Sugiyama, Iwate Medical University, Iwate; Aikou Okamoto, Hiroshi Tanabe, and Seiji Isonishi, The Jikei University School of Medicine; Tetsutaro Hamano, Kitasato University; Yasuhisa Terao, Juntendo University; Mikio Mikami, Tokai University; Hiroyuki Nomura and Daisuke Aoki, Keio University; Fumitoshi Terauchi, Tokyo Medical University, Tokyo; Takayuki Enomoto and Koji Nishino, Niigata University, Niigata; Eriko Aotani, Kanagawa Academy of Science and Technology; Nao Suzuki, St Marianna University, Kanagawa; Nobuo Yaegashi, Tohoku University, Miyagi; Kiyoko Kato, Kyushu University, Fukuoka; Hiroyuki Yoshikawa, University of Tsukuba, Ibaraki; Yoshihito Yokoyama, Hirosaki University, Aomori; Keiichi Fujiwara, Saitama Medical University International Medical Center, Saitama, Japan; Jae-Weon Kim, Seoul National University; Byoung-Gie Kim, Sungkyunkwan University, Seoul, South Korea; Sandro Pignata, Istituto Nazionale Tumori di Napoli, Naples, Italy; Jerome Alexandre, Hôpital Hôtel-Dieu, Montreal, Quebec, Canada; and John Green, University of Liverpool, Liverpool, United Kingdom.
authors.forename: Tetsutaro
authors.initials: T
authors.lastname: Hamano
authors.affiliation: Toru Sugiyama, Iwate Medical University, Iwate; Aikou Okamoto, Hiroshi Tanabe, and Seiji Isonishi, The Jikei University School of Medicine; Tetsutaro Hamano, Kitasato University; Yasuhisa Terao, Juntendo University; Mikio Mikami, Tokai University; Hiroyuki Nomura and Daisuke Aoki, Keio University; Fumitoshi Terauchi, Tokyo Medical University, Tokyo; Takayuki Enomoto and Koji Nishino, Niigata University, Niigata; Eriko Aotani, Kanagawa Academy of Science and Technology; Nao Suzuki, St Marianna University, Kanagawa; Nobuo Yaegashi, Tohoku University, Miyagi; Kiyoko Kato, Kyushu University, Fukuoka; Hiroyuki Yoshikawa, University of Tsukuba, Ibaraki; Yoshihito Yokoyama, Hirosaki University, Aomori; Keiichi Fujiwara, Saitama Medical University International Medical Center, Saitama, Japan; Jae-Weon Kim, Seoul National University; Byoung-Gie Kim, Sungkyunkwan University, Seoul, South Korea; Sandro Pignata, Istituto Nazionale Tumori di Napoli, Naples, Italy; Jerome Alexandre, Hôpital Hôtel-Dieu, Montreal, Quebec, Canada; and John Green, University of Liverpool, Liverpool, United Kingdom.
authors.forename: Eriko
authors.initials: E
authors.lastname: Aotani
authors.affiliation: Toru Sugiyama, Iwate Medical University, Iwate; Aikou Okamoto, Hiroshi Tanabe, and Seiji Isonishi, The Jikei University School of Medicine; Tetsutaro Hamano, Kitasato University; Yasuhisa Terao, Juntendo University; Mikio Mikami, Tokai University; Hiroyuki Nomura and Daisuke Aoki, Keio University; Fumitoshi Terauchi, Tokyo Medical University, Tokyo; Takayuki Enomoto and Koji Nishino, Niigata University, Niigata; Eriko Aotani, Kanagawa Academy of Science and Technology; Nao Suzuki, St Marianna University, Kanagawa; Nobuo Yaegashi, Tohoku University, Miyagi; Kiyoko Kato, Kyushu University, Fukuoka; Hiroyuki Yoshikawa, University of Tsukuba, Ibaraki; Yoshihito Yokoyama, Hirosaki University, Aomori; Keiichi Fujiwara, Saitama Medical University International Medical Center, Saitama, Japan; Jae-Weon Kim, Seoul National University; Byoung-Gie Kim, Sungkyunkwan University, Seoul, South Korea; Sandro Pignata, Istituto Nazionale Tumori di Napoli, Naples, Italy; Jerome Alexandre, Hôpital Hôtel-Dieu, Montreal, Quebec, Canada; and John Green, University of Liverpool, Liverpool, United Kingdom.
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Terao
authors.affiliation: Toru Sugiyama, Iwate Medical University, Iwate; Aikou Okamoto, Hiroshi Tanabe, and Seiji Isonishi, The Jikei University School of Medicine; Tetsutaro Hamano, Kitasato University; Yasuhisa Terao, Juntendo University; Mikio Mikami, Tokai University; Hiroyuki Nomura and Daisuke Aoki, Keio University; Fumitoshi Terauchi, Tokyo Medical University, Tokyo; Takayuki Enomoto and Koji Nishino, Niigata University, Niigata; Eriko Aotani, Kanagawa Academy of Science and Technology; Nao Suzuki, St Marianna University, Kanagawa; Nobuo Yaegashi, Tohoku University, Miyagi; Kiyoko Kato, Kyushu University, Fukuoka; Hiroyuki Yoshikawa, University of Tsukuba, Ibaraki; Yoshihito Yokoyama, Hirosaki University, Aomori; Keiichi Fujiwara, Saitama Medical University International Medical Center, Saitama, Japan; Jae-Weon Kim, Seoul National University; Byoung-Gie Kim, Sungkyunkwan University, Seoul, South Korea; Sandro Pignata, Istituto Nazionale Tumori di Napoli, Naples, Italy; Jerome Alexandre, Hôpital Hôtel-Dieu, Montreal, Quebec, Canada; and John Green, University of Liverpool, Liverpool, United Kingdom.
authors.forename: Nao
authors.initials: N
authors.lastname: Suzuki
authors.affiliation: Toru Sugiyama, Iwate Medical University, Iwate; Aikou Okamoto, Hiroshi Tanabe, and Seiji Isonishi, The Jikei University School of Medicine; Tetsutaro Hamano, Kitasato University; Yasuhisa Terao, Juntendo University; Mikio Mikami, Tokai University; Hiroyuki Nomura and Daisuke Aoki, Keio University; Fumitoshi Terauchi, Tokyo Medical University, Tokyo; Takayuki Enomoto and Koji Nishino, Niigata University, Niigata; Eriko Aotani, Kanagawa Academy of Science and Technology; Nao Suzuki, St Marianna University, Kanagawa; Nobuo Yaegashi, Tohoku University, Miyagi; Kiyoko Kato, Kyushu University, Fukuoka; Hiroyuki Yoshikawa, University of Tsukuba, Ibaraki; Yoshihito Yokoyama, Hirosaki University, Aomori; Keiichi Fujiwara, Saitama Medical University International Medical Center, Saitama, Japan; Jae-Weon Kim, Seoul National University; Byoung-Gie Kim, Sungkyunkwan University, Seoul, South Korea; Sandro Pignata, Istituto Nazionale Tumori di Napoli, Naples, Italy; Jerome Alexandre, Hôpital Hôtel-Dieu, Montreal, Quebec, Canada; and John Green, University of Liverpool, Liverpool, United Kingdom.
authors.forename: Mikio
authors.initials: M
authors.lastname: Mikami
authors.affiliation: Toru Sugiyama, Iwate Medical University, Iwate; Aikou Okamoto, Hiroshi Tanabe, and Seiji Isonishi, The Jikei University School of Medicine; Tetsutaro Hamano, Kitasato University; Yasuhisa Terao, Juntendo University; Mikio Mikami, Tokai University; Hiroyuki Nomura and Daisuke Aoki, Keio University; Fumitoshi Terauchi, Tokyo Medical University, Tokyo; Takayuki Enomoto and Koji Nishino, Niigata University, Niigata; Eriko Aotani, Kanagawa Academy of Science and Technology; Nao Suzuki, St Marianna University, Kanagawa; Nobuo Yaegashi, Tohoku University, Miyagi; Kiyoko Kato, Kyushu University, Fukuoka; Hiroyuki Yoshikawa, University of Tsukuba, Ibaraki; Yoshihito Yokoyama, Hirosaki University, Aomori; Keiichi Fujiwara, Saitama Medical University International Medical Center, Saitama, Japan; Jae-Weon Kim, Seoul National University; Byoung-Gie Kim, Sungkyunkwan University, Seoul, South Korea; Sandro Pignata, Istituto Nazionale Tumori di Napoli, Naples, Italy; Jerome Alexandre, Hôpital Hôtel-Dieu, Montreal, Quebec, Canada; and John Green, University of Liverpool, Liverpool, United Kingdom.
authors.forename: Nobuo
authors.initials: N
authors.lastname: Yaegashi
authors.affiliation: Toru Sugiyama, Iwate Medical University, Iwate; Aikou Okamoto, Hiroshi Tanabe, and Seiji Isonishi, The Jikei University School of Medicine; Tetsutaro Hamano, Kitasato University; Yasuhisa Terao, Juntendo University; Mikio Mikami, Tokai University; Hiroyuki Nomura and Daisuke Aoki, Keio University; Fumitoshi Terauchi, Tokyo Medical University, Tokyo; Takayuki Enomoto and Koji Nishino, Niigata University, Niigata; Eriko Aotani, Kanagawa Academy of Science and Technology; Nao Suzuki, St Marianna University, Kanagawa; Nobuo Yaegashi, Tohoku University, Miyagi; Kiyoko Kato, Kyushu University, Fukuoka; Hiroyuki Yoshikawa, University of Tsukuba, Ibaraki; Yoshihito Yokoyama, Hirosaki University, Aomori; Keiichi Fujiwara, Saitama Medical University International Medical Center, Saitama, Japan; Jae-Weon Kim, Seoul National University; Byoung-Gie Kim, Sungkyunkwan University, Seoul, South Korea; Sandro Pignata, Istituto Nazionale Tumori di Napoli, Naples, Italy; Jerome Alexandre, Hôpital Hôtel-Dieu, Montreal, Quebec, Canada; and John Green, University of Liverpool, Liverpool, United Kingdom.
authors.forename: Kiyoko
authors.initials: K
authors.lastname: Kato
authors.affiliation: Toru Sugiyama, Iwate Medical University, Iwate; Aikou Okamoto, Hiroshi Tanabe, and Seiji Isonishi, The Jikei University School of Medicine; Tetsutaro Hamano, Kitasato University; Yasuhisa Terao, Juntendo University; Mikio Mikami, Tokai University; Hiroyuki Nomura and Daisuke Aoki, Keio University; Fumitoshi Terauchi, Tokyo Medical University, Tokyo; Takayuki Enomoto and Koji Nishino, Niigata University, Niigata; Eriko Aotani, Kanagawa Academy of Science and Technology; Nao Suzuki, St Marianna University, Kanagawa; Nobuo Yaegashi, Tohoku University, Miyagi; Kiyoko Kato, Kyushu University, Fukuoka; Hiroyuki Yoshikawa, University of Tsukuba, Ibaraki; Yoshihito Yokoyama, Hirosaki University, Aomori; Keiichi Fujiwara, Saitama Medical University International Medical Center, Saitama, Japan; Jae-Weon Kim, Seoul National University; Byoung-Gie Kim, Sungkyunkwan University, Seoul, South Korea; Sandro Pignata, Istituto Nazionale Tumori di Napoli, Naples, Italy; Jerome Alexandre, Hôpital Hôtel-Dieu, Montreal, Quebec, Canada; and John Green, University of Liverpool, Liverpool, United Kingdom.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yoshikawa
authors.affiliation: Toru Sugiyama, Iwate Medical University, Iwate; Aikou Okamoto, Hiroshi Tanabe, and Seiji Isonishi, The Jikei University School of Medicine; Tetsutaro Hamano, Kitasato University; Yasuhisa Terao, Juntendo University; Mikio Mikami, Tokai University; Hiroyuki Nomura and Daisuke Aoki, Keio University; Fumitoshi Terauchi, Tokyo Medical University, Tokyo; Takayuki Enomoto and Koji Nishino, Niigata University, Niigata; Eriko Aotani, Kanagawa Academy of Science and Technology; Nao Suzuki, St Marianna University, Kanagawa; Nobuo Yaegashi, Tohoku University, Miyagi; Kiyoko Kato, Kyushu University, Fukuoka; Hiroyuki Yoshikawa, University of Tsukuba, Ibaraki; Yoshihito Yokoyama, Hirosaki University, Aomori; Keiichi Fujiwara, Saitama Medical University International Medical Center, Saitama, Japan; Jae-Weon Kim, Seoul National University; Byoung-Gie Kim, Sungkyunkwan University, Seoul, South Korea; Sandro Pignata, Istituto Nazionale Tumori di Napoli, Naples, Italy; Jerome Alexandre, Hôpital Hôtel-Dieu, Montreal, Quebec, Canada; and John Green, University of Liverpool, Liverpool, United Kingdom.
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Yokoyama
authors.affiliation: Toru Sugiyama, Iwate Medical University, Iwate; Aikou Okamoto, Hiroshi Tanabe, and Seiji Isonishi, The Jikei University School of Medicine; Tetsutaro Hamano, Kitasato University; Yasuhisa Terao, Juntendo University; Mikio Mikami, Tokai University; Hiroyuki Nomura and Daisuke Aoki, Keio University; Fumitoshi Terauchi, Tokyo Medical University, Tokyo; Takayuki Enomoto and Koji Nishino, Niigata University, Niigata; Eriko Aotani, Kanagawa Academy of Science and Technology; Nao Suzuki, St Marianna University, Kanagawa; Nobuo Yaegashi, Tohoku University, Miyagi; Kiyoko Kato, Kyushu University, Fukuoka; Hiroyuki Yoshikawa, University of Tsukuba, Ibaraki; Yoshihito Yokoyama, Hirosaki University, Aomori; Keiichi Fujiwara, Saitama Medical University International Medical Center, Saitama, Japan; Jae-Weon Kim, Seoul National University; Byoung-Gie Kim, Sungkyunkwan University, Seoul, South Korea; Sandro Pignata, Istituto Nazionale Tumori di Napoli, Naples, Italy; Jerome Alexandre, Hôpital Hôtel-Dieu, Montreal, Quebec, Canada; and John Green, University of Liverpool, Liverpool, United Kingdom.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tanabe
authors.affiliation: Toru Sugiyama, Iwate Medical University, Iwate; Aikou Okamoto, Hiroshi Tanabe, and Seiji Isonishi, The Jikei University School of Medicine; Tetsutaro Hamano, Kitasato University; Yasuhisa Terao, Juntendo University; Mikio Mikami, Tokai University; Hiroyuki Nomura and Daisuke Aoki, Keio University; Fumitoshi Terauchi, Tokyo Medical University, Tokyo; Takayuki Enomoto and Koji Nishino, Niigata University, Niigata; Eriko Aotani, Kanagawa Academy of Science and Technology; Nao Suzuki, St Marianna University, Kanagawa; Nobuo Yaegashi, Tohoku University, Miyagi; Kiyoko Kato, Kyushu University, Fukuoka; Hiroyuki Yoshikawa, University of Tsukuba, Ibaraki; Yoshihito Yokoyama, Hirosaki University, Aomori; Keiichi Fujiwara, Saitama Medical University International Medical Center, Saitama, Japan; Jae-Weon Kim, Seoul National University; Byoung-Gie Kim, Sungkyunkwan University, Seoul, South Korea; Sandro Pignata, Istituto Nazionale Tumori di Napoli, Naples, Italy; Jerome Alexandre, Hôpital Hôtel-Dieu, Montreal, Quebec, Canada; and John Green, University of Liverpool, Liverpool, United Kingdom.
authors.forename: Koji
authors.initials: K
authors.lastname: Nishino
authors.affiliation: Toru Sugiyama, Iwate Medical University, Iwate; Aikou Okamoto, Hiroshi Tanabe, and Seiji Isonishi, The Jikei University School of Medicine; Tetsutaro Hamano, Kitasato University; Yasuhisa Terao, Juntendo University; Mikio Mikami, Tokai University; Hiroyuki Nomura and Daisuke Aoki, Keio University; Fumitoshi Terauchi, Tokyo Medical University, Tokyo; Takayuki Enomoto and Koji Nishino, Niigata University, Niigata; Eriko Aotani, Kanagawa Academy of Science and Technology; Nao Suzuki, St Marianna University, Kanagawa; Nobuo Yaegashi, Tohoku University, Miyagi; Kiyoko Kato, Kyushu University, Fukuoka; Hiroyuki Yoshikawa, University of Tsukuba, Ibaraki; Yoshihito Yokoyama, Hirosaki University, Aomori; Keiichi Fujiwara, Saitama Medical University International Medical Center, Saitama, Japan; Jae-Weon Kim, Seoul National University; Byoung-Gie Kim, Sungkyunkwan University, Seoul, South Korea; Sandro Pignata, Istituto Nazionale Tumori di Napoli, Naples, Italy; Jerome Alexandre, Hôpital Hôtel-Dieu, Montreal, Quebec, Canada; and John Green, University of Liverpool, Liverpool, United Kingdom.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nomura
authors.affiliation: Toru Sugiyama, Iwate Medical University, Iwate; Aikou Okamoto, Hiroshi Tanabe, and Seiji Isonishi, The Jikei University School of Medicine; Tetsutaro Hamano, Kitasato University; Yasuhisa Terao, Juntendo University; Mikio Mikami, Tokai University; Hiroyuki Nomura and Daisuke Aoki, Keio University; Fumitoshi Terauchi, Tokyo Medical University, Tokyo; Takayuki Enomoto and Koji Nishino, Niigata University, Niigata; Eriko Aotani, Kanagawa Academy of Science and Technology; Nao Suzuki, St Marianna University, Kanagawa; Nobuo Yaegashi, Tohoku University, Miyagi; Kiyoko Kato, Kyushu University, Fukuoka; Hiroyuki Yoshikawa, University of Tsukuba, Ibaraki; Yoshihito Yokoyama, Hirosaki University, Aomori; Keiichi Fujiwara, Saitama Medical University International Medical Center, Saitama, Japan; Jae-Weon Kim, Seoul National University; Byoung-Gie Kim, Sungkyunkwan University, Seoul, South Korea; Sandro Pignata, Istituto Nazionale Tumori di Napoli, Naples, Italy; Jerome Alexandre, Hôpital Hôtel-Dieu, Montreal, Quebec, Canada; and John Green, University of Liverpool, Liverpool, United Kingdom.
authors.forename: Jae-Weon
authors.initials: JW
authors.lastname: Kim
authors.affiliation: Toru Sugiyama, Iwate Medical University, Iwate; Aikou Okamoto, Hiroshi Tanabe, and Seiji Isonishi, The Jikei University School of Medicine; Tetsutaro Hamano, Kitasato University; Yasuhisa Terao, Juntendo University; Mikio Mikami, Tokai University; Hiroyuki Nomura and Daisuke Aoki, Keio University; Fumitoshi Terauchi, Tokyo Medical University, Tokyo; Takayuki Enomoto and Koji Nishino, Niigata University, Niigata; Eriko Aotani, Kanagawa Academy of Science and Technology; Nao Suzuki, St Marianna University, Kanagawa; Nobuo Yaegashi, Tohoku University, Miyagi; Kiyoko Kato, Kyushu University, Fukuoka; Hiroyuki Yoshikawa, University of Tsukuba, Ibaraki; Yoshihito Yokoyama, Hirosaki University, Aomori; Keiichi Fujiwara, Saitama Medical University International Medical Center, Saitama, Japan; Jae-Weon Kim, Seoul National University; Byoung-Gie Kim, Sungkyunkwan University, Seoul, South Korea; Sandro Pignata, Istituto Nazionale Tumori di Napoli, Naples, Italy; Jerome Alexandre, Hôpital Hôtel-Dieu, Montreal, Quebec, Canada; and John Green, University of Liverpool, Liverpool, United Kingdom.
authors.forename: Byoung-Gie
authors.initials: BG
authors.lastname: Kim
authors.affiliation: Toru Sugiyama, Iwate Medical University, Iwate; Aikou Okamoto, Hiroshi Tanabe, and Seiji Isonishi, The Jikei University School of Medicine; Tetsutaro Hamano, Kitasato University; Yasuhisa Terao, Juntendo University; Mikio Mikami, Tokai University; Hiroyuki Nomura and Daisuke Aoki, Keio University; Fumitoshi Terauchi, Tokyo Medical University, Tokyo; Takayuki Enomoto and Koji Nishino, Niigata University, Niigata; Eriko Aotani, Kanagawa Academy of Science and Technology; Nao Suzuki, St Marianna University, Kanagawa; Nobuo Yaegashi, Tohoku University, Miyagi; Kiyoko Kato, Kyushu University, Fukuoka; Hiroyuki Yoshikawa, University of Tsukuba, Ibaraki; Yoshihito Yokoyama, Hirosaki University, Aomori; Keiichi Fujiwara, Saitama Medical University International Medical Center, Saitama, Japan; Jae-Weon Kim, Seoul National University; Byoung-Gie Kim, Sungkyunkwan University, Seoul, South Korea; Sandro Pignata, Istituto Nazionale Tumori di Napoli, Naples, Italy; Jerome Alexandre, Hôpital Hôtel-Dieu, Montreal, Quebec, Canada; and John Green, University of Liverpool, Liverpool, United Kingdom.
authors.forename: Sandro
authors.initials: S
authors.lastname: Pignata
authors.affiliation: Toru Sugiyama, Iwate Medical University, Iwate; Aikou Okamoto, Hiroshi Tanabe, and Seiji Isonishi, The Jikei University School of Medicine; Tetsutaro Hamano, Kitasato University; Yasuhisa Terao, Juntendo University; Mikio Mikami, Tokai University; Hiroyuki Nomura and Daisuke Aoki, Keio University; Fumitoshi Terauchi, Tokyo Medical University, Tokyo; Takayuki Enomoto and Koji Nishino, Niigata University, Niigata; Eriko Aotani, Kanagawa Academy of Science and Technology; Nao Suzuki, St Marianna University, Kanagawa; Nobuo Yaegashi, Tohoku University, Miyagi; Kiyoko Kato, Kyushu University, Fukuoka; Hiroyuki Yoshikawa, University of Tsukuba, Ibaraki; Yoshihito Yokoyama, Hirosaki University, Aomori; Keiichi Fujiwara, Saitama Medical University International Medical Center, Saitama, Japan; Jae-Weon Kim, Seoul National University; Byoung-Gie Kim, Sungkyunkwan University, Seoul, South Korea; Sandro Pignata, Istituto Nazionale Tumori di Napoli, Naples, Italy; Jerome Alexandre, Hôpital Hôtel-Dieu, Montreal, Quebec, Canada; and John Green, University of Liverpool, Liverpool, United Kingdom.
authors.forename: Jerome
authors.initials: J
authors.lastname: Alexandre
authors.affiliation: Toru Sugiyama, Iwate Medical University, Iwate; Aikou Okamoto, Hiroshi Tanabe, and Seiji Isonishi, The Jikei University School of Medicine; Tetsutaro Hamano, Kitasato University; Yasuhisa Terao, Juntendo University; Mikio Mikami, Tokai University; Hiroyuki Nomura and Daisuke Aoki, Keio University; Fumitoshi Terauchi, Tokyo Medical University, Tokyo; Takayuki Enomoto and Koji Nishino, Niigata University, Niigata; Eriko Aotani, Kanagawa Academy of Science and Technology; Nao Suzuki, St Marianna University, Kanagawa; Nobuo Yaegashi, Tohoku University, Miyagi; Kiyoko Kato, Kyushu University, Fukuoka; Hiroyuki Yoshikawa, University of Tsukuba, Ibaraki; Yoshihito Yokoyama, Hirosaki University, Aomori; Keiichi Fujiwara, Saitama Medical University International Medical Center, Saitama, Japan; Jae-Weon Kim, Seoul National University; Byoung-Gie Kim, Sungkyunkwan University, Seoul, South Korea; Sandro Pignata, Istituto Nazionale Tumori di Napoli, Naples, Italy; Jerome Alexandre, Hôpital Hôtel-Dieu, Montreal, Quebec, Canada; and John Green, University of Liverpool, Liverpool, United Kingdom.
authors.forename: John
authors.initials: J
authors.lastname: Green
authors.affiliation: Toru Sugiyama, Iwate Medical University, Iwate; Aikou Okamoto, Hiroshi Tanabe, and Seiji Isonishi, The Jikei University School of Medicine; Tetsutaro Hamano, Kitasato University; Yasuhisa Terao, Juntendo University; Mikio Mikami, Tokai University; Hiroyuki Nomura and Daisuke Aoki, Keio University; Fumitoshi Terauchi, Tokyo Medical University, Tokyo; Takayuki Enomoto and Koji Nishino, Niigata University, Niigata; Eriko Aotani, Kanagawa Academy of Science and Technology; Nao Suzuki, St Marianna University, Kanagawa; Nobuo Yaegashi, Tohoku University, Miyagi; Kiyoko Kato, Kyushu University, Fukuoka; Hiroyuki Yoshikawa, University of Tsukuba, Ibaraki; Yoshihito Yokoyama, Hirosaki University, Aomori; Keiichi Fujiwara, Saitama Medical University International Medical Center, Saitama, Japan; Jae-Weon Kim, Seoul National University; Byoung-Gie Kim, Sungkyunkwan University, Seoul, South Korea; Sandro Pignata, Istituto Nazionale Tumori di Napoli, Naples, Italy; Jerome Alexandre, Hôpital Hôtel-Dieu, Montreal, Quebec, Canada; and John Green, University of Liverpool, Liverpool, United Kingdom.
authors.forename: Seiji
authors.initials: S
authors.lastname: Isonishi
authors.affiliation: Toru Sugiyama, Iwate Medical University, Iwate; Aikou Okamoto, Hiroshi Tanabe, and Seiji Isonishi, The Jikei University School of Medicine; Tetsutaro Hamano, Kitasato University; Yasuhisa Terao, Juntendo University; Mikio Mikami, Tokai University; Hiroyuki Nomura and Daisuke Aoki, Keio University; Fumitoshi Terauchi, Tokyo Medical University, Tokyo; Takayuki Enomoto and Koji Nishino, Niigata University, Niigata; Eriko Aotani, Kanagawa Academy of Science and Technology; Nao Suzuki, St Marianna University, Kanagawa; Nobuo Yaegashi, Tohoku University, Miyagi; Kiyoko Kato, Kyushu University, Fukuoka; Hiroyuki Yoshikawa, University of Tsukuba, Ibaraki; Yoshihito Yokoyama, Hirosaki University, Aomori; Keiichi Fujiwara, Saitama Medical University International Medical Center, Saitama, Japan; Jae-Weon Kim, Seoul National University; Byoung-Gie Kim, Sungkyunkwan University, Seoul, South Korea; Sandro Pignata, Istituto Nazionale Tumori di Napoli, Naples, Italy; Jerome Alexandre, Hôpital Hôtel-Dieu, Montreal, Quebec, Canada; and John Green, University of Liverpool, Liverpool, United Kingdom.
authors.forename: Fumitoshi
authors.initials: F
authors.lastname: Terauchi
authors.affiliation: Toru Sugiyama, Iwate Medical University, Iwate; Aikou Okamoto, Hiroshi Tanabe, and Seiji Isonishi, The Jikei University School of Medicine; Tetsutaro Hamano, Kitasato University; Yasuhisa Terao, Juntendo University; Mikio Mikami, Tokai University; Hiroyuki Nomura and Daisuke Aoki, Keio University; Fumitoshi Terauchi, Tokyo Medical University, Tokyo; Takayuki Enomoto and Koji Nishino, Niigata University, Niigata; Eriko Aotani, Kanagawa Academy of Science and Technology; Nao Suzuki, St Marianna University, Kanagawa; Nobuo Yaegashi, Tohoku University, Miyagi; Kiyoko Kato, Kyushu University, Fukuoka; Hiroyuki Yoshikawa, University of Tsukuba, Ibaraki; Yoshihito Yokoyama, Hirosaki University, Aomori; Keiichi Fujiwara, Saitama Medical University International Medical Center, Saitama, Japan; Jae-Weon Kim, Seoul National University; Byoung-Gie Kim, Sungkyunkwan University, Seoul, South Korea; Sandro Pignata, Istituto Nazionale Tumori di Napoli, Naples, Italy; Jerome Alexandre, Hôpital Hôtel-Dieu, Montreal, Quebec, Canada; and John Green, University of Liverpool, Liverpool, United Kingdom.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Fujiwara
authors.affiliation: Toru Sugiyama, Iwate Medical University, Iwate; Aikou Okamoto, Hiroshi Tanabe, and Seiji Isonishi, The Jikei University School of Medicine; Tetsutaro Hamano, Kitasato University; Yasuhisa Terao, Juntendo University; Mikio Mikami, Tokai University; Hiroyuki Nomura and Daisuke Aoki, Keio University; Fumitoshi Terauchi, Tokyo Medical University, Tokyo; Takayuki Enomoto and Koji Nishino, Niigata University, Niigata; Eriko Aotani, Kanagawa Academy of Science and Technology; Nao Suzuki, St Marianna University, Kanagawa; Nobuo Yaegashi, Tohoku University, Miyagi; Kiyoko Kato, Kyushu University, Fukuoka; Hiroyuki Yoshikawa, University of Tsukuba, Ibaraki; Yoshihito Yokoyama, Hirosaki University, Aomori; Keiichi Fujiwara, Saitama Medical University International Medical Center, Saitama, Japan; Jae-Weon Kim, Seoul National University; Byoung-Gie Kim, Sungkyunkwan University, Seoul, South Korea; Sandro Pignata, Istituto Nazionale Tumori di Napoli, Naples, Italy; Jerome Alexandre, Hôpital Hôtel-Dieu, Montreal, Quebec, Canada; and John Green, University of Liverpool, Liverpool, United Kingdom.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Aoki
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000188:drug therapy*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives; D016190:Carboplatin / Q000008:administration & dosage / Q000009:adverse effects; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D000077146:Irinotecan; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D017239:Paclitaxel / Q000008:administration & dosage / Q000009:adverse effects; D015996:Survival Rate
chemical_list: D000077146:Irinotecan; D016190:Carboplatin; D017239:Paclitaxel; D002945:Cisplatin; D002166:Camptothecin