title: Sleep, sleep deprivation, autonomic nervous system and cardiovascular diseases.
abstract: Sleep deprivation (SD) has become a relevant health problem in modern societies. We can be sleep deprived due to lifestyle habits or due to sleep disorders, such as insomnia, obstructive sleep apnea (OSA) and neurological disorders. One of the common element of sleep disorders is the condition of chronic SD, which has complex biological consequences. SD is capable of inducing different biological effects, such as neural autonomic control changes, increased oxidative stress, altered inflammatory and coagulatory responses and accelerated atherosclerosis. All these mechanisms links SD and cardiovascular and metabolic disorders. Epidemiological studies have shown that short sleep duration is associated with increased incidence of cardiovascular diseases, such as coronary artery disease, hypertension, arrhythmias, diabetes and obesity, after adjustment for socioeconomic and demographic risk factors and comorbidities. Thus, an early assessment of a condition of SD and its treatment is clinically relevant to prevent the harmful consequences of a very common condition in adult population.
authors.affiliation: Fondazione IRCSS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Tobaldini
authors.affiliation: Fondazione IRCSS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Costantino
authors.affiliation: Fondazione IRCSS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Solbiati
authors.affiliation: Department of Internal Medicine, L. Sacco Hospital, Milan, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Cogliati
authors.affiliation: Division of Cardiovascular Diseases, Heart Hospital of Hamad Medical Corporation, Doha, Qatar; Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
authors.forename: Tomas
authors.initials: T
authors.lastname: Kara
authors.affiliation: C. Munari Center of Epilepsy Surgery, Niguarda Hospital, Milan, Italy.
authors.forename: Lino
authors.initials: L
authors.lastname: Nobili
authors.affiliation: Fondazione IRCSS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy; International Clinical Research Center, St. Anne University Hospital, Brno, Czech Republic. Electronic address: nicola.montano@unimi.it.
authors.forename: Nicola
authors.initials: N
authors.lastname: Montano
mesh_terms: D001341:Autonomic Nervous System; D002318:Cardiovascular Diseases; D006801:Humans; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive; D012892:Sleep Deprivation
keywords: Apnea; Autonomic nervous system; Cardiovascular diseases; Sleep deprivation