title: Atrial natriuretic factor: is it responsible for hyponatremia and natriuresis in neurosurgery?
abstract: OBJECTIVE
  To evaluate the presence of hyponatremia and natriuresis and their association with atrial natriuretic factor in neurosurgery patients.
  
  
  METHODS
  The study included 30 patients who had been submitted to intracranial tumor resection and cerebral aneurism clipping. Both plasma and urinary sodium and plasma atrial natriuretic factor were measured during the preoperative and postoperative time periods.
  
  
  RESULTS
  Hyponatremia was present in 63.33% of the patients, particularly on the first postoperative day. Natriuresis was present in 93.33% of the patients, particularly on the second postoperative day. Plasma atrial natriuretic factor was increased in 92.60% of the patients in at least one of the postoperative days; however, there was no statistically significant association between the atrial natriuretic factor and plasma sodium and between the atrial natriuretic factor and urinary sodium.
  
  
  CONCLUSIONS
  Hyponatremia and natriuresis were present in most patients after neurosurgery; however, the atrial natriuretic factor cannot be considered to be directly responsible for these alterations in neurosurgery patients. Other natriuretic factors are likely to be involved.
authors.affiliation: Departamento de Cirurgia, Faculdade de Medicina, Universidade Estadual de Campinas, Campinas, SP, Brazil.
authors.forename: Ana Paula Devite Cardoso
authors.initials: AP
authors.lastname: Gasparotto
authors.affiliation: Departamento de Cirurgia, Faculdade de Medicina, Universidade Estadual de Campinas, Campinas, SP, Brazil.
authors.forename: Antonio Luis Eiras
authors.initials: AL
authors.lastname: Falcão
authors.affiliation: Departamento de Cirurgia, Faculdade de Medicina, Universidade Estadual de Campinas, Campinas, SP, Brazil.
authors.forename: Carolina
authors.initials: C
authors.lastname: Kosour
authors.affiliation: Departamento de Cirurgia, Faculdade de Medicina, Universidade Estadual de Campinas, Campinas, SP, Brazil.
authors.forename: Sebastião
authors.initials: S
authors.lastname: Araújo
authors.affiliation: Departamento de Enfermagem, Faculdade de Medicina, Universidade Estadual de Campinas, Campinas, SP, Brazil.
authors.forename: Eliane Araújo
authors.initials: EA
authors.lastname: Cintra
authors.affiliation: Departamento de Fisioterapia, Pontifícia Universidade Católica de Campinas, Campinas, SP, Brazil.
authors.forename: Rosmari Aparecida Rosa Almeida de
authors.initials: RA
authors.lastname: Oliveira
authors.affiliation: Departamento de Cirurgia, Faculdade de Medicina, Universidade Estadual de Campinas, Campinas, SP, Brazil.
authors.forename: Luiz Claudio
authors.initials: LC
authors.lastname: Martins
authors.affiliation: Departamento de Cirurgia, Faculdade de Medicina, Universidade Estadual de Campinas, Campinas, SP, Brazil.
authors.forename: Desanka
authors.initials: D
authors.lastname: Dragosavac
mesh_terms: D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood*; D001932:Brain Neoplasms / Q000601:surgery; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000453:epidemiology*; D002532:Intracranial Aneurysm / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009318:Natriuresis / Q000502:physiology*; D019635:Neurosurgical Procedures / Q000379:methods*; D011184:Postoperative Period; D057234:Preoperative Period; D011446:Prospective Studies; D012964:Sodium / Q000652:urine
chemical_list: D009320:Atrial Natriuretic Factor; D012964:Sodium