title: Nuclear Transcription Factors in the Mitochondria: A New Paradigm in Fine-Tuning Mitochondrial Metabolism.
abstract: Noncanonical functions of several nuclear transcription factors in the mitochondria have been gaining exceptional traction over the years. These transcription factors include nuclear hormone receptors like estrogen, glucocorticoid, and thyroid hormone receptors: p53, IRF3, STAT3, STAT5, CREB, NF-kB, and MEF-2D. Mitochondria-localized nuclear transcription factors regulate mitochondrial processes like apoptosis, respiration and mitochondrial transcription albeit being nuclear in origin and having nuclear functions. Hence, the cell permits these multi-stationed transcription factors to orchestrate and fine-tune cellular metabolism at various levels of operation. Despite their ubiquitous distribution in different subcompartments of mitochondria, their targeting mechanism is poorly understood. Here, we review the current status of mitochondria-localized transcription factors and discuss the possible targeting mechanism besides the functional interplay between these factors.
authors.affiliation: Department of Biochemistry, School of Life Sciences, University of Hyderabad, Telangana, 500046, India. nareshuohyd@gmail.com.
authors.forename: Naresh Babu V
authors.initials: NBV
authors.lastname: Sepuri
authors.affiliation: Department of Biochemistry, School of Life Sciences, University of Hyderabad, Telangana, 500046, India.
authors.forename: Prasad
authors.initials: P
authors.lastname: Tammineni
authors.affiliation: Department of Biochemistry, School of Life Sciences, University of Hyderabad, Telangana, 500046, India.
authors.forename: Fareed
authors.initials: F
authors.lastname: Mohammed
authors.affiliation: Department of Biochemistry, School of Life Sciences, University of Hyderabad, Telangana, 500046, India.
authors.forename: Arunkumar
authors.initials: A
authors.lastname: Paripati
mesh_terms: D000818:Animals; D017362:Cyclic AMP Response Element-Binding Protein / Q000502:physiology; D006801:Humans; D050838:Interferon Regulatory Factor-3 / Q000502:physiology; D008928:Mitochondria / Q000378:metabolism*; D016328:NF-kappa B / Q000502:physiology; D021381:Protein Transport; D011960:Receptors, Estrogen / Q000032:analysis; D011965:Receptors, Glucocorticoid / Q000032:analysis; D011988:Receptors, Thyroid Hormone / Q000032:analysis; D050791:STAT Transcription Factors / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology*
chemical_list: D017362:Cyclic AMP Response Element-Binding Protein; C494232:IRF3 protein, human; D050838:Interferon Regulatory Factor-3; D016328:NF-kappa B; D011960:Receptors, Estrogen; D011965:Receptors, Glucocorticoid; D011988:Receptors, Thyroid Hormone; D050791:STAT Transcription Factors; D014157:Transcription Factors
keywords: Metabolism; Mitochondria; Nuclear receptors and transcription factors; Protein import; Protein targeting and signaling