title: Phytochemical and biological investigations of Amaryllidaceae alkaloids: a review.
abstract: Amaryllidaceae is a family that includes 75 genera and about 1100 species, which have a long history of medicinal use. Many plants have been proven to possess efficacy for neurological injury and inflammatory conditions. This article summarizes 357 Amaryllidaceae alkaloids, and cites 166 174 references over the last three decades. These alkaloids are classified into 14 skeleton types, and their abundant sources are also included. Modern pharmacology studies demonstrate that alkaloids that exclusively occur in Amaryllidaceae plant possess wide-ranging pharmacological actions, especially effects on the central nervous system, as well as antitumor, antimicrobial, and anti-inflammatory activities. Effective monomeric compounds from Amaryllidaceae screened for pharmacological activity in vivo and in vitro are also summarized.
authors.affiliation: a School of Food Science and Technology , Dalian Polytechnic University , Dalian 116034 , China.|b Institute of Chemistry and Applications of Plant Resources, Dalian Polytechnic University , Dalian 116034 , China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Ding
authors.affiliation: a School of Food Science and Technology , Dalian Polytechnic University , Dalian 116034 , China.
authors.forename: Dan
authors.initials: D
authors.lastname: Qu
authors.affiliation: a School of Food Science and Technology , Dalian Polytechnic University , Dalian 116034 , China.
authors.forename: Kai-Mei
authors.initials: KM
authors.lastname: Zhang
authors.affiliation: a School of Food Science and Technology , Dalian Polytechnic University , Dalian 116034 , China.
authors.forename: Xiao-Xin
authors.initials: XX
authors.lastname: Cang
authors.affiliation: c Instrumental Analysis Center, Dalian Polytechnic University , Dalian 116034 , China.
authors.forename: Zi-Nong
authors.initials: ZN
authors.lastname: Kou
authors.affiliation: d Jiangsu Kanion Pharmaceutical Co. Ltd , Lianyungang 222001 , China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xiao
authors.affiliation: a School of Food Science and Technology , Dalian Polytechnic University , Dalian 116034 , China.|b Institute of Chemistry and Applications of Plant Resources, Dalian Polytechnic University , Dalian 116034 , China.
authors.forename: Jing-Bo
authors.initials: JB
authors.lastname: Zhu
mesh_terms: D047151:Amaryllidaceae Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology*; D002490:Central Nervous System / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure
chemical_list: D047151:Amaryllidaceae Alkaloids; D000893:Anti-Inflammatory Agents
keywords: Amaryllidaceae; alkaloids; anti-Alzheimer’s disease; antitumor; chemical structure