title: Platelet Activation: The Mechanisms and Potential Biomarkers.
abstract: Beyond hemostasis and thrombosis, an increasing number of studies indicate that platelets play an integral role in intercellular communication, mediating inflammatory and immunomodulatory activities. Our knowledge about how platelets modulate inflammatory and immunity has greatly improved in recent years. In this review, we discuss recent advances in the pathways of platelet activation and potential application of platelet activation biomarkers to diagnosis and prediction of disease states.
authors.affiliation: Department of Biochemistry, Dong-A University College of Medicine, 26 Daesingongwon-ro, Seo-gu, Busan 49201, Republic of Korea.
authors.forename: Seong-Hoon
authors.initials: SH
authors.lastname: Yun
authors.affiliation: Department of Biochemistry, Dong-A University College of Medicine, 26 Daesingongwon-ro, Seo-gu, Busan 49201, Republic of Korea.
authors.forename: Eun-Hye
authors.initials: EH
authors.lastname: Sim
authors.affiliation: Department of Laboratory Medicine, Dong-A University College of Medicine, 26 Daesingongwon-ro, Seo-gu, Busan 49201, Republic of Korea.
authors.forename: Ri-Young
authors.initials: RY
authors.lastname: Goh
authors.affiliation: Department of Biochemistry, Dong-A University College of Medicine, 26 Daesingongwon-ro, Seo-gu, Busan 49201, Republic of Korea.
authors.forename: Joo-In
authors.initials: JI
authors.lastname: Park
authors.affiliation: Department of Laboratory Medicine, Dong-A University College of Medicine, 26 Daesingongwon-ro, Seo-gu, Busan 49201, Republic of Korea.
authors.forename: Jin-Yeong
authors.identifier: 0000-0003-0280-2739
authors.initials: JY
authors.lastname: Han
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000276:immunology / Q000378:metabolism; D006801:Humans; D056747:Immunomodulation; D007249:Inflammation / Q000097:blood / Q000175:diagnosis / Q000276:immunology; D015539:Platelet Activation / Q000276:immunology*
chemical_list: D015415:Biomarkers