title: [Antiviral action and pathogenetic targets for seaweed sulfated polysaccharides in herpesvirus infections].
abstract: The review summarizes results of studies of effects of sulfated polysaccharides from seaweed on herpesviruses and the course of herpesvirus infections. Importance of this problem is determined by the prevalence of herpesviruses that can persist in the human body and demonstrate a high degree of immune mimicry and resistance to antiviral agents. A wide range of physiological action of sulfated polysaccharides, receptor agonists of innate and adaptive immune cells, which possess potent antiviral, antioxidant and anti-inflammatory activities, open the possibility of their use for creation of new generation pharmacological substances and agents with associated activity for the treatment of herpesvirus infections.
authors.affiliation: Somov Scientific Research Institute of Epidemiology and Microbiology, Vladivostok, Russia.
authors.forename: N N
authors.initials: NN
authors.lastname: Besednova
authors.affiliation: Somov Scientific Research Institute of Epidemiology and Microbiology, Vladivostok, Russia.
authors.forename: I D
authors.initials: ID
authors.lastname: Makarenkova
authors.affiliation: Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Vladivostok, Russia.
authors.forename: T N
authors.initials: TN
authors.lastname: Zvyagintseva
authors.affiliation: Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Vladivostok, Russia.
authors.forename: T I
authors.initials: TI
authors.lastname: Imbs
authors.affiliation: Somov Scientific Research Institute of Epidemiology and Microbiology, Vladivostok, Russia.
authors.forename: L M
authors.initials: LM
authors.lastname: Somova
authors.affiliation: Somov Scientific Research Institute of Epidemiology and Microbiology, Vladivostok, Russia.
authors.forename: T S
authors.initials: TS
authors.lastname: Zaporozhets
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D006564:Herpesviridae / Q000187:drug effects*; D006566:Herpesviridae Infections / Q000188:drug therapy*; D006801:Humans; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D011134:Polysaccharides / Q000494:pharmacology* / Q000627:therapeutic use; D012624:Seaweed / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D000998:Antiviral Agents; D010936:Plant Extracts; D011134:Polysaccharides
keywords: antiviral activity; fucoidan; herpes viruses; sulfated polysaccharides