title: Synthesis, Characterizations of Superparamagnetic Fe3O4-Ag Hybrid Nanoparticles and Their Application for Highly Effective Bacteria Inactivation.
abstract: In recent years, outbreaks of infectious diseases caused by pathogenic micro-organisms pose a serious threat to public health. In this work, Fe3O4-Ag hybrid nanoparticles were synthesized by simple chemistry method and these prepared nanoparticles were used to investigate their antibacterial properties and mechanism against methicilline-resistant Staphylococcus aureus (MRSA) pathogen. The formation of dimer-like nanostructure of Fe3O4-Ag hybrid NPs was confirmed by X-ray diffraction and High-resolution Transmission Electron Microscopy. Our biological analysis revealed that the Fe3O4-Ag hybrid NPs showed more noticeable bactericidal activity than that of plain Fe3O4 NPs and Ag-NPs. We suggest that the enhancement in bactericidal activity of Fe3O4-Ag hybrid NPs might be likely from main factors such as: (i) enhanced surface area property of hybrid nanoparticles; (ii) the high catalytic activity of Ag-NPs with good dispersion and aggregation stability due to the iron oxide magnetic carrier, and (iii) large direct physical contacts between the bacterial cell membrane and the hybrid nanoparticles. The superparamagnetic hybrid nanoparticles of iron oxide magnetic nanoparticles decorated with silver nanoparticles can be a potential candidate to effectively treat infectious MRSA pathogen with recyclable capability, targeted bactericidal delivery and minimum release into environment.
authors.forename: Le Minh
authors.initials: le M
authors.lastname: Tung
authors.forename: Nguyen Xuan
authors.initials: NX
authors.lastname: Cong
authors.forename: Le Thanh
authors.initials: le T
authors.lastname: Huy
authors.forename: Nguyen Thi
authors.initials: NT
authors.lastname: Lan
authors.forename: Vu Ngoc
authors.initials: VN
authors.lastname: Phan
authors.forename: Nguyen Quang
authors.initials: NQ
authors.lastname: Hoa
authors.forename: Le Khanh
authors.initials: le K
authors.lastname: Vinh
authors.forename: Nguyen Viet
authors.initials: NV
authors.lastname: Thinh
authors.forename: Le Thanh
authors.initials: le T
authors.lastname: Tai
authors.forename: Duc-The
authors.initials: DT
authors.lastname: Ngo
authors.forename: Kristian
authors.initials: K
authors.lastname: Mølhave
authors.forename: Tran Quang
authors.initials: TQ
authors.lastname: Huy
authors.forename: Anh-Tuan
authors.initials: AT
authors.lastname: Le
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D050296:Microbial Viability / Q000187:drug effects*; D036103:Nanotechnology; D055668:Photochemical Processes; D012834:Silver / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000502:physiology
chemical_list: D000900:Anti-Bacterial Agents; D058185:Magnetite Nanoparticles; D012834:Silver