title: Delivering therapeutics in peripheral artery disease: challenges and future perspectives.
abstract: Targeted and sustained delivery of biologicals to improve neovascularization has been focused on stimulation angiogenesis. The formation of collaterals however is hemodynamically much more efficient, but as a target of therapy has been under-utilized. Although there is good understanding of the molecular processes involving collateral formation and there are interesting drugable candidates, the need for targeting and sustained delivery is still an obstacle towards safe and effective treatment. Molecular targeting with nanoparticles of liposomes is promising and so are peri-vascularly delivered polymer-based protein reservoirs. These developments will lead to future arteriogenesis strategies that are adjunct to current revascularization.
authors.affiliation: Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Universiteitssingel 50, 6229 ER, Maastricht, The Netherlands.
authors.forename: Mark Hm
authors.initials: MH
authors.lastname: Vries
authors.affiliation: Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Universiteitssingel 50, 6229 ER, Maastricht, The Netherlands.|P.O. Box 616, 6200 MD Maastricht, The Netherlands.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Post
mesh_terms: D016503:Drug Delivery Systems / Q000639:trends; D006801:Humans; D008081:Liposomes; D053758:Nanoparticles; D018919:Neovascularization, Physiologic; D058729:Peripheral Arterial Disease / Q000503:physiopathology
chemical_list: D008081:Liposomes
keywords: chemokine; collateral formation; liposomes; neovascularization; polymer drug carriers