title: Elevated GDF11 Is a Risk Factor for Age-Related Frailty and Disease in Humans.
abstract: GDF11 was reported to decline with age and to have muscle and heart rejuvenating effects. These reports were disputed. A Cell Metabolism paper now shows that in human beings, GDF11 does not decline with age and is actually a risk factor for frailty and other morbidities (Schafer et al., 2016).
authors.affiliation: Novartis Institutes for Biomedical Research, 181 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address: david.glass@novartis.com.
authors.forename: David J
authors.initials: DJ
authors.lastname: Glass
mesh_terms: D019485:Bone Morphogenetic Proteins; D055412:Growth Differentiation Factors; D006321:Heart; D006801:Humans; D012307:Risk Factors
chemical_list: D019485:Bone Morphogenetic Proteins; D055412:Growth Differentiation Factors