title: Influence of BclI C/G (rs41423247) on hippocampal shape and white matter integrity of the parahippocampal cingulum in major depressive disorder.
abstract: We investigated the interactive effects of BclI C/G (rs41423247) allelic variants and the diagnosis of major depressive disorder (MDD) on hippocampal shape and integrity of the left parahippocampal subdivision of the cingulum. Fifty-two patients with MDD and 52 healthy controls (HCs) underwent T1-weighted structural magnetic resonance imaging and BclI C/G (rs41423247) genotyping. We analyzed hippocampal shape using the FIRST module of FSL and analyzed white matter (WM) integrity using diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS). Significant alterations in left hippocampal shape and decreased fractional anisotropy (FA) values of the left parahippocampal cingulum were observed in MDD patients, compared to HCs. In addition, MDD patients of the BclI minor (G-) allele carrier group showed significant alterations in left hippocampal shape and decreased FA values of the left parahippocampal cingulum compared to BclI minor (G-) allele carrier HCs. No significant differences between diagnostic subgroups of the C/C homozygotes were observed. Our study provides evidence for alterations in hippocampal shape and decreased integrity of the WM region associated with the hippocampus in MDD, and for the possible influence of BclI C/G polymorphism (rs41423247) on hippocampal shape and integrity of the parahippocampal subdivision of the cingulum in depression.
authors.affiliation: Department of Psychiatry, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
authors.forename: Eunsoo
authors.initials: E
authors.lastname: Won
authors.affiliation: Department of Biomedical Science, Korea University, Seoul, Republic of Korea.
authors.forename: June
authors.initials: J
authors.lastname: Kang
authors.affiliation: Department of Biomedical Science, Korea University, Seoul, Republic of Korea.
authors.forename: Aram
authors.initials: A
authors.lastname: Kim
authors.affiliation: Department of Brain and Cognitive Engineering, Korea University, Seoul, Republic of Korea.
authors.forename: Sunyoung
authors.initials: S
authors.lastname: Choi
authors.affiliation: Department of Psychiatry, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
authors.forename: Kyu-Man
authors.initials: KM
authors.lastname: Han
authors.affiliation: Brain Convergence Research Center, Anam Hospital, Korea University Medical Center, Seoul, Republic of Korea.
authors.forename: Woo Suk
authors.initials: WS
authors.lastname: Tae
authors.affiliation: Department of Medical Bioscience, Graduate School, Soonchunhyang University, Bucheon, Republic of Korea.
authors.forename: Hun Soo
authors.initials: HS
authors.lastname: Chang
authors.affiliation: Department of Radiology, Korea University Medical Center, Korea University College of Medicine, Seoul, Republic of Korea.
authors.forename: Kyu Ri
authors.initials: KR
authors.lastname: Son
authors.affiliation: Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, USA.
authors.forename: Tsafrir
authors.initials: T
authors.lastname: Greenberg
authors.affiliation: Department of Psychiatry, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
authors.forename: Sook-Haeng
authors.initials: SH
authors.lastname: Joe
authors.affiliation: Department of Psychiatry, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
authors.forename: Min-Soo
authors.initials: MS
authors.lastname: Lee
authors.affiliation: Department of Psychiatry, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea. Electronic address: hambj@korea.ac.kr.
authors.forename: Byung-Joo
authors.initials: BJ
authors.lastname: Ham
mesh_terms: D000328:Adult; D003865:Major Depressive Disorder / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology*; D056324:Diffusion Tensor Imaging; D005260:Female; D006624:Hippocampus / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D065726:Limbic Lobe / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011965:Receptors, Glucocorticoid / Q000235:genetics*; D066127:White Matter / Q000000981:diagnostic imaging / Q000473:pathology*
chemical_list: C497713:NR3C1 protein, human; D011965:Receptors, Glucocorticoid
keywords: BclI C/G (rs41423247); Hippocampus; Major depressive disorder; Parahippocampal cingulum