title: Inherited thrombophilia in women with poor aPL-related obstetric history: prevalence and outcomes. Survey of 208 cases from the European Registry on Obstetric Antiphospholipid Syndrome cohort.
abstract: To analyse the prevalence and effects of inherited thrombophilic disorders (ITD) on maternal-foetal outcomes in cases of antiphospholipid antibody related to obstetric complications.
  
  
  
  Women with obstetric complaints who tested positive for aPL and with inherited thrombophilia were prospectively and retrospectively included.
  
  
  
  ITD data were available in 208 of 338: 147 had obstetric antiphospholipid syndrome (OAPS) and 61 aPL-related obstetric morbidity (OMAPS). 24.1% had ITD. Laboratory categories I and IIa were more related to OAPS-ITD and IIb and IIc to OMAPS-ITD. No significant differences in obstetric complaints were observed. Regarding ITD carriers, treatment rates were higher in OAPS than in OMAPS for LMWH and LDA plus LMWH (P=.002).
  
  
  
  Cases with aPL-related OAPS/OMAPS showed no differences in maternal-foetal outcomes regardless of the presence of one ITD. Maternal thrombotic risk was low, with ITD-positive cases included. Registry data concur with Sydney criteria, whereby aPL-ITD-positive patients are classified as having antiphospholipid syndrome.
authors.affiliation: Systemic Autoimmune Disease Unit, Department of Internal Medicine, Vall d'Hebron University Hospital, Barcelona, Spain.|Department of Medicine, Universitat Autonoma, Barcelona, Spain.
authors.forename: Jaume
authors.initials: J
authors.lastname: Alijotas-Reig
authors.affiliation: Obstetric and Gynaecolgy Department, Vall d'Hebron University Hospital, Universitat Autonoma, Barcelona, Spain.
authors.forename: Raquel
authors.initials: R
authors.lastname: Ferrer-Oliveras
authors.affiliation: Systemic Autoimmune Disease Unit, Department of Internal Medicine, Vall d'Hebron University Hospital, Barcelona, Spain.|Internal Medicine Department, Althaia Healthcare Network of Manresa, Barcelona, Spain.
authors.forename: Enrique
authors.initials: E
authors.lastname: Esteve-Valverde
authors.affiliation: Rheumatology Unit, Department of Clinical and Experimental Medicine Azienda Ospedaliera, University of Padua, Padua, Italy.
authors.forename: Amelia
authors.initials: A
authors.lastname: Ruffatti
authors.affiliation: Rheumatology and Clinial Immunology Unit, Ospedale Civile, Brescia, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Tincani
authors.affiliation: Haematology Unit, Hippokration Hospital of Thessaloniki, Thessaloniki, Greece.
authors.forename: Elmina
authors.initials: E
authors.lastname: Lefkou
authors.affiliation: Department of Clinical Immunology, A.O. Mauriziano-Umberto I, Turin, Italy.
authors.forename: Maria Tiziana
authors.initials: MT
authors.lastname: Bertero
authors.affiliation: Systemic Autoimmune Diseases Service, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain.
authors.forename: Gerard
authors.initials: G
authors.lastname: Espinosa
authors.affiliation: Systemic Autoimmune Diseases Service, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Coloma
authors.affiliation: Depatment of Gynaecology, Gemmeli Hospital, Catholic University, Roma, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: de Carolis
authors.affiliation: Pregnancy and Rheumatic Diseases Clinic Unit of Medicine and Clinical Immunology IRCCS Ospedale San Raffaele Università Vita-Salute San Raffaele, Milano, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Rovere-Querini
authors.affiliation: Pregnancy and Rheumatic Diseases Clinic Unit of Medicine and Clinical Immunology IRCCS Ospedale San Raffaele Università Vita-Salute San Raffaele, Milano, Italy.|Laboratorio Autoimmunità e Inflammazione Voscolare - San Raffaele DIBIT, Milano, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Canti
authors.affiliation: Department of Obstetrics and Gynaecology, University of Turin, Turin, Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Picardo
authors.affiliation: Rheumatology and Clinial Immunology Unit, Ospedale Civile, Brescia, Italy.
authors.forename: Micaela
authors.initials: M
authors.lastname: Fredi
authors.affiliation: Department of Medicine, Hôpital Saint-Antoine, Universite Est Parisien, Paris, France.
authors.forename: Arsene
authors.initials: A
authors.lastname: Mekinian
mesh_terms: D000328:Adult; D016736:Antiphospholipid Syndrome / Q000150:complications / Q000453:epidemiology*; D005060:Europe / Q000453:epidemiology; D005260:Female; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000453:epidemiology*; D011256:Pregnancy Outcome / Q000453:epidemiology*; D015995:Prevalence; D012042:Registries; D019851:Thrombophilia / Q000150:complications / Q000453:epidemiology*
keywords: antiphospholipid antibody; inherited thrombophilia; obstetric outcome; thrombosis; treatment