title: Metformin inhibits development of colon malignant tumors induced by 1,2-dimethylhydrazine in rats.
abstract: It has been shown that metformin dose-dependently inhibits the development of colon tumors induced by 1,2-dimethylhydrazine (DMH) in rats. The metformin effect manifested itself as a decrease in the amount and average size of tumors, increased degree of their differentiation, and reduction of invasion depth, which was more pronounced in the group of animals that received metformin at a dose of 100 mg/kg of body weight as compared with rats treated with metformin at a dose of 300 mg/kg.
authors.affiliation: St. Petersburg State University, St. Petersburg, 197183, Russia. v.bekusova@spbu.ru.
authors.forename: V V
authors.initials: VV
authors.lastname: Bekusova
authors.affiliation: Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, 199034, Russia.
authors.forename: V M
authors.initials: VM
authors.lastname: Patsanovskii
authors.affiliation: St. Petersburg State University, St. Petersburg, 197183, Russia.
authors.forename: A D
authors.initials: AD
authors.lastname: Nozdrachev
authors.affiliation: Petrov Research Institute of Oncology, Ministry of Health of Russia, St. Petersburg, 197758, Russia.
authors.forename: V N
authors.initials: VN
authors.lastname: Anisimov
mesh_terms: D019813:1,2-Dimethylhydrazine / Q000633:toxicity*; D000818:Animals; D003110:Colonic Neoplasms / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D008297:Male; D008687:Metformin / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D008687:Metformin; D019813:1,2-Dimethylhydrazine