title: The hidden side of SERPINB1/Leukocyte Elastase Inhibitor.
abstract: SERPINB1, also called Leukocyte Elastase Inhibitor (LEI) is a member of the clade B of SERPINS. It is an intracellular protein and acts primarily to protect the cell from proteases released into the cytoplasm during stress. Its role in inflammation is clear due to its involvement in the resolution of chronic inflammatory lung and bowel diseases. LEI/SERPINB1 intrinsically possesses two enzymatic activities: an antiprotease activity dependent on its reactive site loop, which is analogous to the other proteins of the family and an endonuclease activity which is unveiled by the cleavage of the reactive site loop. The conformational change induced by this cleavage also unveils a bipartite nuclear localization signal allowing the protein to translocate to the nucleus. Recent data indicate that it has also a role in cell migration suggesting that it could be involved in diverse processes like wound healing and malignant metastases.
authors.affiliation: INSERM U1138, Centre de Recherches des Cordeliers, Université Paris Descartes, Université Pierre et Marie Curie, Paris, France. Electronic address: alicia.torriglia@inserm.fr.
authors.forename: Alicia
authors.initials: A
authors.lastname: Torriglia
authors.affiliation: INSERM U1138, Centre de Recherches des Cordeliers, Université Paris Descartes, Université Pierre et Marie Curie, Paris, France.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Martin
authors.affiliation: INSERM U1138, Centre de Recherches des Cordeliers, Université Paris Descartes, Université Pierre et Marie Curie, Paris, France; Ecole Nationale Vétérinaire d'Alfort, France.
authors.forename: Imene
authors.initials: I
authors.lastname: Jaadane
mesh_terms: D000818:Animals; D017209:Apoptosis; D019143:Evolution, Molecular; D006801:Humans; D019272:Leukocyte Elastase / Q000378:metabolism*; D010802:Phylogeny; D011480:Protease Inhibitors / Q000378:metabolism*; D015843:Serpins / Q000378:metabolism*
chemical_list: D011480:Protease Inhibitors; D015843:Serpins; D019272:Leukocyte Elastase
keywords: Apoptosis; Cell migration; Inflammation; L-DNase II; Leukocyte elastase inhibitor; Murine neutrophil elastase inhibitor; Serpin B1