title: [ANTIPLATELET AND ANTI-ISCHEMIC EFFECTS OF MEMANTINE AND 5-HYDROXYADAMANTAN-2-ONE IN PATIENTS WITH CEREBROVASCULAR PATHOLOGY AND IN EXPERIMENTS].
abstract: It was investigated the effect of two adamantane derivatives, memantine and 5-hydroxyadamantan-2-one (5-HA), in patients with cerebrovascular disorders. In vitro studies showed that 5-HA, unlike memantine, exhibited antiplatelet activity. Experiments showed that memantine reduced cerebral blood flow in the brain cortex of intact rats and those under conditions of transient global ischemia, whereas 5-HA only selectively improved blood flow in ischemic brain and was superior to the reference drug nimodipine. The obtained data indicate the leading role of the GABA-ergic (rather than glutamatergic mechanisms) in implementation of the anti-ischemic cerebrovascular activity.
authors.forename: M M
authors.initials: MM
authors.lastname: Tanashyan
authors.forename: A A
authors.initials: AA
authors.lastname: Shabalina
authors.forename: E V
authors.initials: EV
authors.lastname: Gnedovskaya
authors.forename: T S
authors.initials: TS
authors.lastname: Gan'shina
authors.forename: E V
authors.initials: EV
authors.lastname: Kurza
authors.forename: D V
authors.initials: DV
authors.lastname: Maslennikov
authors.forename: R S
authors.initials: RS
authors.lastname: Mirzoyan
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives / Q000494:pharmacology*; D000244:Adenosine Diphosphate / Q000494:pharmacology; D000368:Aged; D000818:Animals; D021461:Animals, Outbred Strains; D001792:Blood Platelets / Q000187:drug effects; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000098:blood supply / Q000187:drug effects / Q000473:pathology; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004837:Epinephrine / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D005260:Female; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000188:drug therapy* / Q000473:pathology; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000473:pathology; D017078:Laser-Doppler Flowmetry; D008297:Male; D008559:Memantine / Q000494:pharmacology*; D008875:Middle Aged; D009553:Nimodipine / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D018691:Excitatory Amino Acid Antagonists; D014665:Vasodilator Agents; D009553:Nimodipine; D000244:Adenosine Diphosphate; D000218:Adamantane; D008559:Memantine; D004837:Epinephrine