title: Catalytic Macrocyclization Strategies Using Continuous Flow: Formal Total Synthesis of Ivorenolide A.
abstract: A formal total synthesis of ivorenolide A has been accomplished employing a Z-selective olefin cross metathesis and a macrocyclic Glaser-Hay coupling as key steps. The macrocyclization protocol employed a phase separation/continuous flow manifold whose advantages include catalysis, fast reaction times, high concentrations, and facile scale-up.
authors.affiliation: Department of Chemistry and Centre for Green Chemistry and Catalysis, Université de Montréal , CP 6128 Station Downtown, Montréal, Québec, Canada H3C 3J7.
authors.forename: Mylène
authors.initials: M
authors.lastname: de Léséleuc
authors.affiliation: Department of Chemistry and Centre for Green Chemistry and Catalysis, Université de Montréal , CP 6128 Station Downtown, Montréal, Québec, Canada H3C 3J7.
authors.forename: Éric
authors.initials: É
authors.lastname: Godin
authors.affiliation: Department of Chemistry and Centre for Green Chemistry and Catalysis, Université de Montréal , CP 6128 Station Downtown, Montréal, Québec, Canada H3C 3J7.
authors.forename: Shawn
authors.initials: S
authors.lastname: Parisien-Collette
authors.affiliation: Department of Chemistry and Centre for Green Chemistry and Catalysis, Université de Montréal , CP 6128 Station Downtown, Montréal, Québec, Canada H3C 3J7.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Lévesque
authors.affiliation: Department of Chemistry and Centre for Green Chemistry and Catalysis, Université de Montréal , CP 6128 Station Downtown, Montréal, Québec, Canada H3C 3J7.
authors.forename: Shawn K
authors.initials: SK
authors.lastname: Collins