title: Focal epileptic seizures, electroencephalography and outcome of sepsis associated encephalopathy-A pilot study.
abstract: OBJECTIVE
  Sepsis associated encephalopathy (SAE) represents a diffuse and/or multifactorial cerebral dysfunction during response to systemic infection. Study aim was to compare clinical and electroencephalogram (EEG) characteristics and intrahospital survival rate among SAE patients.
  
  
  METHODS
  A prospective study, during 42 months' period, included 39 SAE patients assigned in two groups according the outcome (survival: 19, and death: 20 patients). All the patients' features were registered: demography, neurological status, infection type, seizure appearance, brain computerized tomography (CT), EEG, EEG reactivity, Glasgow Coma Score (GCS) and Acute Physiology and Chronic Health Evaluation II (APACHE II) Score. The analysis included EEGs obtained during patients' consciousness change (improvement or deterioration) and the level of consciousness during and at the end of hospitalization.
  
  
  RESULTS
  SAE was detected in 29.5% of patients with encephalopathy (2.8% of all patients hospitalized). Patients with lethal outcome were more likely to be female (p=0.0011), to have focal seizures (p=0.034), lower values of GCS during hospitalization (p<0.05) and longer lasting nosocomial infections (p=0.029). At the time of clinical exacerbation, patients were more likely to have suppression on EEG and less likely theta activity. Delta waves, TW waves and suppression of EEG activity were the most common findings 24h prior to death (p=0.0004). The lack of EEG reactivity was associated with death (p=0.00043).
  
  
  CONCLUSIONS
  Presence of focal seizures, EEG suppression at the time of exacerbation in SAE elderly patients, particularly women, with longer infection duration and lower values of GCS, is associated with intrahospital death.
authors.affiliation: Department of Emergency Neurology, Neurology Clinic, Clinical Centre of Serbia, Belgrade, Serbia; University of Belgrade, Faculty of Medicine, Belgrade, Serbia. Electronic address: ivanaberisavac@gmail.com.
authors.forename: I I
authors.initials: II
authors.lastname: Berisavac
authors.affiliation: Department of Emergency Neurology, Neurology Clinic, Clinical Centre of Serbia, Belgrade, Serbia.
authors.forename: V V
authors.initials: VV
authors.lastname: Padjen
authors.affiliation: Department of Emergency Neurology, Neurology Clinic, Clinical Centre of Serbia, Belgrade, Serbia; University of Belgrade, Faculty of Medicine, Belgrade, Serbia.
authors.forename: M D
authors.initials: MD
authors.lastname: Ercegovac
authors.affiliation: Department of Emergency Neurology, Neurology Clinic, Clinical Centre of Serbia, Belgrade, Serbia; University of Belgrade, Faculty of Medicine, Belgrade, Serbia.
authors.forename: Lj G
authors.initials: LjG
authors.lastname: Beslać-Bumbaširević
authors.affiliation: Department of Emergency Neurology, Neurology Clinic, Clinical Centre of Serbia, Belgrade, Serbia.
authors.forename: P Dj
authors.initials: PDj
authors.lastname: Stanarčević
authors.affiliation: Department of Emergency Neurology, Neurology Clinic, Clinical Centre of Serbia, Belgrade, Serbia.
authors.forename: M S
authors.initials: MS
authors.lastname: Stefanović-Budimkić
authors.affiliation: University of Belgrade, Faculty of Medicine, Belgrade, Serbia; Clinic of Nephrology, Clinical Centre of Serbia, Serbia.
authors.forename: M M
authors.initials: MM
authors.lastname: Radović
authors.affiliation: Department of Emergency Neurology, Neurology Clinic, Clinical Centre of Serbia, Belgrade, Serbia; University of Belgrade, Faculty of Medicine, Belgrade, Serbia.
authors.forename: D R
authors.initials: DR
authors.lastname: Jovanović
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004569:Electroencephalography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care / Q000706:statistics & numerical data*; D010865:Pilot Projects; D011446:Prospective Studies; D012640:Seizures / Q000453:epidemiology / Q000401:mortality / Q000503:physiopathology*; D065166:Sepsis-Associated Encephalopathy / Q000453:epidemiology / Q000401:mortality / Q000503:physiopathology*; D012737:Sex Factors
keywords: EEG; Seizure; Sepsis associated encephalopathy