title: Rhodomentones A and B, novel meroterpenoids with unique NMR characteristics from Rhodomyrtus tomentosa.
abstract: Two novel meroterpenoids, rhodomentones A and B bearing an unprecedented caryophyllene-conjugated oxa-spiro[5.8] tetradecadiene skeleton, were isolated from the leaves of Rhodomyrtus tomentosa. Their structures with unique NMR characteristics were determined by extensive spectroscopic analysis, single-crystal X-ray diffraction, quantum molecular calculation, chemical transformation as well as total synthesis.
authors.affiliation: Program for Natural Products Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China. tanhaibo@scbg.ac.cn sxqiu@scbg.ac.cn and State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, China.
authors.forename: Hong-Xin
authors.initials: HX
authors.lastname: Liu
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Chen
authors.affiliation: Program for Natural Products Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China. tanhaibo@scbg.ac.cn sxqiu@scbg.ac.cn.
authors.forename: Yao
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: Program for Natural Products Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China. tanhaibo@scbg.ac.cn sxqiu@scbg.ac.cn.
authors.forename: Zhi-Fang
authors.initials: ZF
authors.lastname: Xu
authors.affiliation: Program for Natural Products Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China. tanhaibo@scbg.ac.cn sxqiu@scbg.ac.cn.
authors.forename: Hai-Bo
authors.initials: HB
authors.lastname: Tan
authors.affiliation: Program for Natural Products Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China. tanhaibo@scbg.ac.cn sxqiu@scbg.ac.cn.
authors.forename: Sheng-Xiang
authors.initials: SX
authors.lastname: Qiu
mesh_terms: D000072283:A549 Cells; D000900:Anti-Bacterial Agents; D002470:Cell Survival; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D002942:Circular Dichroism; D018360:Crystallography, X-Ray / Q000379:methods; D055808:Drug Discovery; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D027822:Myrtaceae / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D000081223:Polycyclic Sesquiterpenes; D021281:Quantitative Structure-Activity Relationship; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification; D013141:Spiro Compounds / Q000737:chemistry* / Q000302:isolation & purification; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D010936:Plant Extracts; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; D013141:Spiro Compounds; D013729:Terpenes; C024714:caryophyllene