title: Granulocyte-Colony Stimulating Factor (G-CSF) Administration for Chemotherapy-Induced Neutropenia.
abstract: This study was aimed to evaluate the efficacy of G-CSF (Granulocyte colony stimulating factor) administration to 37 patients with neutropenia following intensive combination chemotherapy. The patients were divided into two subgroups including solid tumors given ifosfamide and etoposide combination chemotherapy (IMET subgroup) and acute myeloid leukemia (AML) patients treated with mitoxantrone and cytarabine. Control group consisted of 31 acute myeloid leukemia patients. G-CSF was started on the first day of absolute neutropenia until the absolute neutrophil count was above 1000/mm(3) for two consecutive days. G-CSF was found to be effective for early recovery of neutrophil count. Expected response was achieved within 14 days in 91.5% of the courses with a median of fifth day of G-CSF treatment. In conclusion, this study showed the efficacy of G-CSF in early recovery of neutrophil count without any reduction in the incidence of febrile episodes and documented rates of bacterial and fungal infections in patients with acute myeloid leukemia.
authors.affiliation: a Hacettepe University, Institute of Oncology , Ankara , Turkey.
authors.forename: Ş
authors.initials: Ş
authors.lastname: Yalçin
authors.affiliation: a Hacettepe University, Institute of Oncology , Ankara , Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Güler
authors.affiliation: a Hacettepe University, Institute of Oncology , Ankara , Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Kansu
authors.affiliation: a Hacettepe University, Institute of Oncology , Ankara , Turkey.
authors.forename: I
authors.initials: I
authors.lastname: Ertenli
authors.affiliation: a Hacettepe University, Institute of Oncology , Ankara , Turkey.
authors.forename: I
authors.initials: I
authors.lastname: Güllü
authors.affiliation: a Hacettepe University, Institute of Oncology , Ankara , Turkey.
authors.forename: I
authors.initials: I
authors.lastname: Barişta
authors.affiliation: a Hacettepe University, Institute of Oncology , Ankara , Turkey.
authors.forename: I
authors.initials: I
authors.lastname: Çelik
authors.affiliation: a Hacettepe University, Institute of Oncology , Ankara , Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Kars
authors.affiliation: a Hacettepe University, Institute of Oncology , Ankara , Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Tekuzman
authors.affiliation: a Hacettepe University, Institute of Oncology , Ankara , Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Baltali
authors.affiliation: a Hacettepe University, Institute of Oncology , Ankara , Turkey.
authors.forename: D
authors.initials: D
authors.lastname: Firat
keywords: Acute Leukemia; Febrile Neutropenia; G-CSF; Solid Tumor