title: Energy Remodeling, Mitochondrial Disorder and Heart Failure.
abstract: Heart failure (HF) is a major global problem in public health with no curative treatment currently available. Energy remodeling is one of the features in HF, preceding cardiac structure remodeling. As an important energy organelle, mitochondrion plays critical roles in the progress of HF. This review focuses on the potential mechanisms linking mitochondrial functions and energy remodeling in HF including the energy starvation theory and energy substrate metabolism. It also highlights the potentials of novel drugs targeting HF energy metabolism.
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.forename: Lei
authors.initials: L
authors.lastname: Xu
authors.affiliation: Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China. sun.aijun@zs-hospital.sh.cn.
authors.forename: Aijun
authors.initials: A
authors.lastname: Sun
mesh_terms: D000620:Aminoimidazole Carboxamide / Q000031:analogs & derivatives / Q000627:therapeutic use; D000818:Animals; D004734:Energy Metabolism; D006333:Heart Failure / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D008687:Metformin / Q000627:therapeutic use; D028361:Mitochondrial Diseases / Q000188:drug therapy / Q000378:metabolism*; D012265:Ribonucleotides / Q000627:therapeutic use; D045162:Thiazolidinediones / Q000627:therapeutic use; D014292:Trimetazidine / Q000627:therapeutic use
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D012265:Ribonucleotides; D045162:Thiazolidinediones; D000620:Aminoimidazole Carboxamide; D008687:Metformin; C031143:AICA ribonucleotide; D014292:Trimetazidine