title: A Pluripotency Platform for Prdm14.
abstract: The tripartite network of Prdm14, Blimp1, and AP2γ is essential for the important process of germ cell specification, but their precise molecular mechanisms of action remain lacking. Tu and colleagues (2016) report in Nature that the transcriptional co-repressor CBFA2T2 is an essential interactor protein regulating PRDM14 function, shedding light into the mechanisms directing germline formation and pluripotency.
authors.affiliation: Institute of Epigenetics and Stem Cells, Helmholtz Zentrum München, 81377 München, Germany. Electronic address: adam.burton@helmholtz-muenchen.de.
authors.forename: Adam
authors.initials: A
authors.lastname: Burton
authors.affiliation: Institut de Génétique et de Biologie Moléculaire et Cellulaire, INSERM U964, 67404 Illkirch, CU de Strasbourg, France; Institute of Epigenetics and Stem Cells, Helmholtz Zentrum München, 81377 München, Germany.
authors.forename: Maria-Elena
authors.initials: ME
authors.lastname: Torres-Padilla
mesh_terms: D004268:DNA-Binding Proteins; D018507:Gene Expression Regulation, Developmental; D005854:Germ Cells / Q000166:cytology* / Q000378:metabolism; D006801:Humans; D039904:Pluripotent Stem Cells / Q000166:cytology* / Q000378:metabolism; D000074462:Positive Regulatory Domain I-Binding Factor 1; D016601:RNA-Binding Proteins; D012097:Repressor Proteins / Q000378:metabolism*; D050656:Transcription Factor AP-2 / Q000378:metabolism*; D014157:Transcription Factors
chemical_list: C110408:CBFA2T2 myeloid-transforming gene-related protein; D004268:DNA-Binding Proteins; C524724:PRDM14 protein, human; D016601:RNA-Binding Proteins; D012097:Repressor Proteins; D050656:Transcription Factor AP-2; D014157:Transcription Factors; C087042:PRDM1 protein, human; D000074462:Positive Regulatory Domain I-Binding Factor 1