title: A salt bridge turns off the foot-pocket in class-II HDACs.
abstract: Histone Deacetylases (HDACs) are promising anticancer targets and several selective inhibitors have been created based on the architectural differences of foot-pockets among HDACs. However, the "gate-keeper" of foot-pockets is still controversial. Herein, it is for the first time revealed that a conserved R-E salt bridge plays a critical role in keeping foot-pockets closed in class-II HDACs by computational simulations. This finding is further substantiated by our mutagenesis experiments.
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, P. R. China. wurb3@mail.sysu.edu.cn limin65@mail.sysu.edu.cn.
authors.forename: Jingwei
authors.initials: J
authors.lastname: Zhou
authors.forename: Zuolong
authors.initials: Z
authors.lastname: Yang
authors.forename: Fan
authors.initials: F
authors.lastname: Zhang
authors.forename: Hai-Bin
authors.initials: HB
authors.lastname: Luo
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.forename: Ruibo
authors.initials: R
authors.lastname: Wu