title: Acute eosinophilic pneumonia caused by camostat mesilate: The first case report.
abstract: Camostat mesilate is in widespread clinical use mainly to treat chronic pancreatitis, and drug-induced lung injury has not been previously reported. However, pulmonary infiltration with peripheral blood eosinophilia appeared after taking camostat mesilate for ten days. The histological findings showed eosinophilic infiltration into the alveolar space and interstitum, and drug lymphocyte stimulation test of peripheral blood was positive. Both peripheral blood eosinophilia and pulmonary involvements improved two weeks later with the cessation of this drug. To the best of our knowledge, this case is the first report of camostat mesilate-induced acute eosinophilic pneumonia.
authors.affiliation: Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Ota
authors.affiliation: Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, Japan; Respiratory Disease Center, Yokohama City University Medical Center, Kanagawa, Japan.
authors.forename: Yu
authors.initials: Y
authors.lastname: Hara
authors.affiliation: Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
authors.forename: Soichiro
authors.initials: S
authors.lastname: Kanoh
authors.affiliation: Respiratory Disease Center, Yokohama City University Medical Center, Kanagawa, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Shinoda
authors.affiliation: Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
authors.forename: Shuichi
authors.initials: S
authors.lastname: Kawano
authors.affiliation: Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Fujikura
authors.affiliation: Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kawana
authors.affiliation: Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, Japan; Respiratory Disease Center, Yokohama City University Medical Center, Kanagawa, Japan.
authors.forename: Masaharu
authors.initials: M
authors.lastname: Shinkai
keywords: BALF, bronchoalveolar lavage fluid; Camostat mesilate; DLST, drug lymphocyte stimulation test; Drug cessation; Drug lymphocyte stimulation test; Drug-induced lung injury; Eosinophilic pneumonia; GGO, ground glass opacities; HRCT, High-resolution computed tomography