title: The hepatic FOXQ1 transcription factor regulates glucose metabolism in mice.
abstract: Hepatic forkhead box q1 (FOXQ1) expression levels are regulated by nutritional and pathophysiological status. In this study we investigated the role of FOXQ1 in the regulation of hepatic gluconeogenesis.
  
  
  
  We used multiple mouse and cell models to study the role of FOXQ1 in regulating expression of gluconeogenic genes, and cellular and hepatic glucose production.
  
  
  
  Expression of hepatic FOXQ1 was regulated by fasting in normal mice and was dysregulated in diabetic mice. Overexpression of FOXQ1 in primary hepatocytes inhibited expression of gluconeogenic genes and decreased cellular glucose output. Hepatic FOXQ1 rescue in db/db and high-fat diet-induced obese mice markedly decreased blood glucose level and improved glucose intolerance. In contrast, wild-type C57 mice with hepatic FOXQ1 deficiency displayed increased blood glucose levels and impaired glucose tolerance. Interestingly, studies into molecular mechanisms indicated that FOXQ1 interacts with FOXO1, thereby blocking FOXO1 activity on hepatic gluconeogenesis, preventing it from directly binding to insulin response elements mapped in the promoter region of gluconeogenic genes.
  
  
  
  FOXQ1 is a novel factor involved in regulating hepatic gluconeogenesis, and the decreased FOXQ1 expression in liver may contribute to the development of type 2 diabetes.
authors.affiliation: National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, 5 Dong Dan San Tiao, Beijing, 100005, People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Cui
authors.affiliation: National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, 5 Dong Dan San Tiao, Beijing, 100005, People's Republic of China.
authors.forename: Aijun
authors.initials: A
authors.lastname: Qiao
authors.affiliation: National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, 5 Dong Dan San Tiao, Beijing, 100005, People's Republic of China.
authors.forename: Tao
authors.initials: T
authors.lastname: Jiao
authors.affiliation: National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, 5 Dong Dan San Tiao, Beijing, 100005, People's Republic of China.
authors.forename: Huabing
authors.initials: H
authors.lastname: Zhang
authors.affiliation: National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, 5 Dong Dan San Tiao, Beijing, 100005, People's Republic of China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Xue
authors.affiliation: National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, 5 Dong Dan San Tiao, Beijing, 100005, People's Republic of China.
authors.forename: Yongkang
authors.initials: Y
authors.lastname: Zou
authors.affiliation: National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, 5 Dong Dan San Tiao, Beijing, 100005, People's Republic of China.
authors.forename: Anfang
authors.initials: A
authors.lastname: Cui
authors.affiliation: National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, 5 Dong Dan San Tiao, Beijing, 100005, People's Republic of China.
authors.forename: Fude
authors.initials: F
authors.lastname: Fang
authors.affiliation: National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, 5 Dong Dan San Tiao, Beijing, 100005, People's Republic of China. changy@ibms.pumc.edu.cn.
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Chang
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D059305:Diet, High-Fat / Q000009:adverse effects; D005215:Fasting / Q000097:blood; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000378:metabolism*; D005943:Gluconeogenesis / Q000235:genetics / Q000502:physiology; D018149:Glucose Intolerance; D022781:Hepatocytes / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D008099:Liver; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese
chemical_list: D001786:Blood Glucose; D051858:Forkhead Transcription Factors; C107579:Foxq1 protein, mouse; D007328:Insulin
keywords: FOXO1; FOXQ1; Gluconeogenesis; Type 2 diabetes