title: MRI gray and white matter measures in progressive supranuclear palsy and corticobasal syndrome.
abstract: We evaluated MRI measures of gray and white matter damages in 19 patients with progressive supranuclear palsy (PSP), 11 with corticobasal syndrome (CBS), and 14 healthy subjects (HS) to differentiate patients with PSP from those with CBS. We calculated surface-based maps of the cortical volume, cortical thickness, surface area, and voxel level maps of sub-cortical volume, and diffusion tensor imaging parameters using automated scripts implemented in FreeSurfer and FSL toolboxes. No significant differences in cortical volume loss were observed between PSP and CBS. When cortical volume was divided into cortical thickness and surface area, cortical thickness in peri-rolandic brain regions was significantly smaller in CBS than in PSP patients, whereas surface area was significantly smaller in PSP than HS. We also found widespread volume loss in sub-cortical structures in patients with PSP and CBS in comparison to HS. Both patient groups displayed diffusion tensor imaging abnormalities: compared to HS, widespread fractional anisotropy and radial diffusivity changes were observed in PSP, whereas axial and radial diffusivity changes were prominent in CBS. Mini-mental state examination positively correlated with diffusion changes in patients with PSP. In conclusion, cortical thickness, surface area, and diffusion tensor imaging parameters may be sensitive enough to help differentiate patients with PSP from those with CBS.
authors.affiliation: Department of Neurology and Psychiatry, "Sapienza" University of Rome, Viale dell'Università, 30, 00185, Rome, Italy.
authors.forename: Neeraj
authors.initials: N
authors.lastname: Upadhyay
authors.affiliation: Department of Neurology and Psychiatry, "Sapienza" University of Rome, Viale dell'Università, 30, 00185, Rome, Italy.|IRCCS INM Neuromed, Pozzilli, IS, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Suppa
authors.affiliation: Department of Neurology and Psychiatry, "Sapienza" University of Rome, Viale dell'Università, 30, 00185, Rome, Italy.
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Piattella
authors.affiliation: Department of Neurology and Psychiatry, "Sapienza" University of Rome, Viale dell'Università, 30, 00185, Rome, Italy.|IRCCS INM Neuromed, Pozzilli, IS, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Bologna
authors.affiliation: IRCCS INM Neuromed, Pozzilli, IS, Italy.
authors.forename: Flavio
authors.initials: F
authors.lastname: Di Stasio
authors.affiliation: Department of Neurology and Psychiatry, "Sapienza" University of Rome, Viale dell'Università, 30, 00185, Rome, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Formica
authors.affiliation: Department of Neurology and Psychiatry, "Sapienza" University of Rome, Viale dell'Università, 30, 00185, Rome, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Tona
authors.affiliation: Department of Neurology, Santa Maria University Hospital, Terni, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Colosimo
authors.affiliation: Department of Neurology and Psychiatry, "Sapienza" University of Rome, Viale dell'Università, 30, 00185, Rome, Italy.|IRCCS INM Neuromed, Pozzilli, IS, Italy.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Berardelli
authors.affiliation: Department of Neurology and Psychiatry, "Sapienza" University of Rome, Viale dell'Università, 30, 00185, Rome, Italy. patrizia.pantano@uniroma1.it.|IRCCS INM Neuromed, Pozzilli, IS, Italy. patrizia.pantano@uniroma1.it.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Pantano
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D016880:Anisotropy; D001921:Brain / Q000473:pathology*; D001927:Brain Diseases / Q000473:pathology*; D056324:Diffusion Tensor Imaging; D005260:Female; D066128:Gray Matter / Q000000981:diagnostic imaging*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011712:Pyramidal Tracts / Q000000981:diagnostic imaging*; D013494:Supranuclear Palsy, Progressive / Q000473:pathology*; D066127:White Matter / Q000000981:diagnostic imaging*
keywords: Corticobasal syndrome; DTI parameters; Progressive supranuclear palsy; Surface-based morphometric measures