title: [Antidepressive Combination Treatment in Patients with Severe Depressive Episode: The Practice of Prescription in a Clinical Sample 2012].
abstract: ObjectivesPolypharmacy in the treatment of severe psychiatric disorders may include promising treatment options, yet may also be subject to additional side effects and interactions. In patients with severe depression, the prevalence of antidepressive (AD) combination treatment has not been thoroughly assessed yet.MethodsWe assessed the prevalence of antidepressive combination treatment in a sample of hospital patients at the LVR-Clinic in Düsseldorf, Germany in 2012.Results1.198 residential or semi-residential patients were diagnosed with severe depressive episode and were treated with at least one antidepressant. 25.1 % of those received a combination of at least two antidepressants. The most frequent combination approaches were tri- and tetracyclic AD with selective serotonin reuptake inhibitors (SSRI) yet various other combination approaches were observed.ConclusionsCombination treatment is a common strategy. Future trends could be monitored via electronic prescription software, yet prospective confirmatory trials are needed to assess the rationale of different combination treatment approaches.
authors.affiliation: LVR-Klinikum Düsseldorf, Kliniken der Heinrich-Heine-Universität Düsseldorf.
authors.forename: Christian
authors.initials: C
authors.lastname: Schmidt-Kraepelin
authors.affiliation: LVR-Klinikum Düsseldorf, Kliniken der Heinrich-Heine-Universität Düsseldorf.
authors.forename: Eva
authors.initials: E
authors.lastname: Horstkötter
authors.affiliation: LVR-Klinikum Düsseldorf, Kliniken der Heinrich-Heine-Universität Düsseldorf.|LVR-Institut für Versorgungsforschung, LVR-Klinikum Düsseldorf, Kliniken der Heinrich-Heine-Universität Düsseldorf.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Zielasek
authors.affiliation: LVR-Institut für Versorgungsforschung, LVR-Klinikum Düsseldorf, Kliniken der Heinrich-Heine-Universität Düsseldorf.
authors.forename: Marina
authors.initials: M
authors.lastname: Otten
authors.affiliation: LVR-Klinikum Düsseldorf, Kliniken der Heinrich-Heine-Universität Düsseldorf.
authors.forename: Joachim
authors.initials: J
authors.lastname: Cordes
mesh_terms: D000293:Adolescent; D000328:Adult; D000928:Antidepressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D003631:Day Care, Medical; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010343:Patient Admission; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D000928:Antidepressive Agents