title: Synthesis and Anti-Proliferative Activity of Sulfanyltriazolylnaphthalenols and Sulfanyltriazolylnaphthalene-1,4-diones.
abstract: A series of new sulfanyltriazolylnaphthalenols (10a-f and 13a-f) and sulfanyltriazolylnaphthalene-1,4-diones (14a-f) were synthesized and evaluated against a panel of cancer cell lines. Among the tested compounds, 10b and 10d showed the best anti-proliferative activity with GI50 values ranging from 2.72 to 10 and 3.13 to 13.1 µM, respectively, in several of the tumor cell lines tested. Compound 10d is highly selective toward leukemia cell lines and can be regarded as a good model for the development of new anti-leukemic agents.
authors.affiliation: Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Alexandria University, Alexandria, Egypt.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Chaaban
authors.affiliation: Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Alexandria University, Alexandria, Egypt.
authors.forename: El Sayeda M
authors.initials: el SM
authors.lastname: El Khawass
authors.affiliation: Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Alexandria University, Alexandria, Egypt. heba_attia75@yahoo.com.
authors.forename: Heba A
authors.initials: HA
authors.lastname: Abd El Razik
authors.affiliation: Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Alexandria University, Alexandria, Egypt.|Faculty of Pharmacy, Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Helsinki, Finland.
authors.forename: Nehad S
authors.initials: NS
authors.lastname: El Salamouni
authors.affiliation: Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Madrid, Spain.
authors.forename: Mariano
authors.initials: M
authors.lastname: Redondo-Horcajo
authors.affiliation: Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Madrid, Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: Barasoain
authors.affiliation: Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Madrid, Spain.
authors.forename: José Fernando
authors.initials: JF
authors.lastname: Díaz
authors.affiliation: Faculty of Pharmacy, Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Helsinki, Finland.
authors.forename: Jari
authors.initials: J
authors.lastname: Yli-Kauhaluoma
authors.affiliation: Faculty of Pharmacy, Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Helsinki, Finland.
authors.forename: Vânia M
authors.initials: VM
authors.lastname: Moreira
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D009281:Naphthalenes
keywords: Cancer; Leukemia; Quinone; Sulfanyltriazolylnaphthalenols; Synthesis