title: Endoscopic Options for Gastroesophageal Reflux: Where Are We Now and What Does the Future Hold?
abstract: Early in the twenty-first century, novel endoscopic techniques were introduced for the management of gastroesophageal reflux disease, providing minimally invasive ways to eliminate pharmacologic acid inhibition and avoid the need for anti-reflux surgery. These techniques do not significantly alter the anatomy of the gastroesophageal junction, minimizing short- and long-term adverse effects, such as dysphagia and bloating. After extensive clinical testing, many endoscopic therapies were abandoned due to either lack of durable efficacy or unfavorable safety profile. Today, only four such therapies remain clinically available, each with variable levels of clinical validation and market penetration. This review will provide an assessment of these endoscopic therapies, highlighting their respective strengths and weaknesses and their present and future applicability to patients with gastroesophageal reflux disease.
authors.affiliation: Division of Gastroenterology and Hepatology, Stanford University School of Medicine, 300 Pasteur Drive, M-211, Stanford, CA, 94306, USA. vagt@stanford.edu.
authors.forename: George
authors.initials: G
authors.lastname: Triadafilopoulos
mesh_terms: D050110:Bariatric Surgery / Q000379:methods; D017115:Catheter Ablation / Q000379:methods; D004945:Esophagoscopy / Q000379:methods* / Q000639:trends; D018662:Fundoplication / Q000379:methods; D005764:Gastroesophageal Reflux / Q000188:drug therapy / Q000209:etiology / Q000601:surgery*; D006801:Humans; D019060:Minimally Invasive Surgical Procedures / Q000379:methods; D054328:Proton Pump Inhibitors / Q000627:therapeutic use
chemical_list: D054328:Proton Pump Inhibitors
keywords: Endoscopic anti-reflux therapy (EART); Endoscopy; Gastroesophageal reflux disease (GERD); Laparoscopy; Minimally invasive solutions; Proton pump inhibitor