title: Structural Brain Connectivity and the Sit-to-Stand-to-Sit Performance in Individuals with Nonspecific Low Back Pain: A Diffusion Magnetic Resonance Imaging-Based Network Analysis.
abstract: Individuals with nonspecific low back pain (NSLBP) show an impaired sensorimotor control. They need significantly more time to perform five consecutive sit-to-stand-to-sit (STSTS) movements compared with healthy controls. Optimal sensorimotor control depends on the coactivation of many brain regions, which have to operate as a coordinated network to achieve correct motor output. Therefore, the examination of brain connectivity from a network perspective is crucial for understanding the factors that drive sensorimotor control. In the current study, potential alterations in structural brain networks of individuals with NSLBP and the correlation with the performance of the STSTS task were investigated. Seventeen individuals with NSLBP and 17 healthy controls were instructed to perform five consecutive STSTS movements as fast as possible. In addition, data of diffusion magnetic resonance imaging were acquired and analyzed using a graph theoretical approach. Results showed that individuals with NSLBP needed significantly more time to perform the STSTS task compared with healthy controls (p < 0.05). Both groups exhibited small-world properties in their structural networks. However, local efficiency was significantly decreased in the patients with NSLBP compared with controls (p < 0.05, false discovery rate [FDR] corrected). Moreover, global efficiency was significantly correlated with the sensorimotor task performance within the NSLBP group (r = -0.73, p = 0.002). Our data show disrupted network organization of white matter networks in patients with NSLBP, which may contribute to their persistent pain and sensorimotor disabilities.
authors.affiliation: 1 Department of Rehabilitation Sciences, KU Leuven-University of Leuven , Leuven, Belgium .|2 Department of Allied Health Professions, Fontys University of Applied Sciences , Eindhoven, The Netherlands .
authors.forename: Madelon
authors.initials: M
authors.lastname: Pijnenburg
authors.affiliation: 3 Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University , Stanford, California.
authors.forename: S M Hadi
authors.initials: SM
authors.lastname: Hosseini
authors.affiliation: 1 Department of Rehabilitation Sciences, KU Leuven-University of Leuven , Leuven, Belgium .
authors.forename: Simon
authors.initials: S
authors.lastname: Brumagne
authors.affiliation: 1 Department of Rehabilitation Sciences, KU Leuven-University of Leuven , Leuven, Belgium .|4 Biomedical Research Institute, Hasselt University , Diepenbeek, Belgium .
authors.forename: Lotte
authors.initials: L
authors.lastname: Janssens
authors.affiliation: 1 Department of Rehabilitation Sciences, KU Leuven-University of Leuven , Leuven, Belgium .
authors.forename: Nina
authors.initials: N
authors.lastname: Goossens
authors.affiliation: 5 Faculty of Health Sciences, School of Psychology, Australian Catholic University , Melbourne, Australia .
authors.forename: Karen
authors.initials: K
authors.lastname: Caeyenberghs
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology; D001931:Brain Mapping; D016022:Case-Control Studies; D063132:Connectome / Q000379:methods; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D017116:Low Back Pain / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology; D009415:Nerve Net / Q000473:pathology; D009434:Neural Pathways / Q000473:pathology; D066191:Sensorimotor Cortex / Q000502:physiology*; D066127:White Matter / Q000502:physiology
keywords: back pain; brain connectivity; graph theory; sensorimotor system; white matter