title: Donor-Derived Coccidioides immitis Endocarditis and Disseminated Infection in the Setting of Solid Organ Transplantation.
abstract: Background.  Endocarditis is a rare manifestation of infection with Coccidioides. This is the first reported case of donor-derived Coccidioides endocarditis obtained from a heart transplant. Methods.  We present a unique case of donor-derived Coccidioides immitis endocarditis and disseminated infection in a heart transplant patient. We also conducted a review of the literature to identify other cases of donor-derived coccidioidomycosis in solid organ transplant recipients and reviewed their clinical characteristics. Results.  Fifteen prior cases of donor-derived coccidioidomycosis were identified. A majority of these cases were diagnosed by positive culture (83%). Mortality was high at 58%. Conclusions.  Clinicians should maintain a high index of suspicion for disseminated coccidioidomycosis in patients who received transplants with organs from donors with a history of residing in endemic regions.
authors.affiliation: Division of Infectious Diseases and Geographic Medicine.
authors.forename: Joanna K
authors.initials: JK
authors.lastname: Nelson
authors.affiliation: Montreal Heart Institute , Canada.
authors.forename: Genevieve
authors.initials: G
authors.lastname: Giraldeau
authors.affiliation: Division of Infectious Diseases and Geographic Medicine.
authors.forename: Jose G
authors.initials: JG
authors.lastname: Montoya
authors.affiliation: Division of Infectious Diseases and Geographic Medicine.
authors.forename: Stan
authors.initials: S
authors.lastname: Deresinski
authors.affiliation: Division of Infectious Diseases and Geographic Medicine.
authors.forename: Dora Y
authors.initials: DY
authors.lastname: Ho
authors.affiliation: Department of Cardiovascular Medicine , Stanford University School of Medicine , California.
authors.forename: Michael
authors.initials: M
authors.lastname: Pham
keywords: coccidioidomycosis; donor-derive; endocarditis; solid organ transplant