title: Mindfulness meditation-based pain relief: a mechanistic account.
abstract: Pain is a multidimensional experience that involves interacting sensory, cognitive, and affective factors, rendering the treatment of chronic pain challenging and financially burdensome. Further, the widespread use of opioids to treat chronic pain has led to an opioid epidemic characterized by exponential growth in opioid misuse and addiction. The staggering statistics related to opioid use highlight the importance of developing, testing, and validating fast-acting nonpharmacological approaches to treat pain. Mindfulness meditation is a technique that has been found to significantly reduce pain in experimental and clinical settings. The present review delineates findings from recent studies demonstrating that mindfulness meditation significantly attenuates pain through multiple, unique mechanisms-an important consideration for the millions of chronic pain patients seeking narcotic-free, self-facilitated pain therapy.
authors.affiliation: Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
authors.forename: Fadel
authors.initials: F
authors.lastname: Zeidan
authors.affiliation: Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
authors.forename: David R
authors.initials: DR
authors.lastname: Vago
mesh_terms: D059350:Chronic Pain / Q000523:psychology / Q000628:therapy*; D006801:Humans; D019122:Meditation / Q000379:methods*; D064866:Mindfulness / Q000379:methods*; D059408:Pain Management / Q000379:methods*; D016896:Treatment Outcome
keywords: fMRI; mindfulness meditation; opioid; pain; placebo