title: Malignant pleural mesothelioma with lacrimal gland metastasis.
abstract: OBJECTIVE
  To describe a rare clinical case of biopsy-proven metastatic mesothelioma of the lacrimal gland which responded well to chemo and radiation therapy.
  
  
  METHODS
  Interventional case report.
  
  
  RESULTS
  A 55-year-old woman with an untreated malignant biopsy-proven pleural mesothelioma presented with right proptosis, diplopia and hypoglobus. Magnetic resonance imaging showed an aggressive lacrimal gland tumour with bony erosion. A biopsy concluded a diagnosis of metastatic mesothelioma of the lacrimal gland. Her lacrimal and lung tumours showed a marked regression following palliative chemo (carboplatin) and radiation therapy.
  
  
  CONCLUSIONS
  Malignant pleural mesothelioma may metastasize to the orbit, including the lacrimal gland. A combined chemo and radiation therapy may reduce the size of the metastatic and primary tumour.
authors.affiliation: Department of Oculoplastic and Orbital Surgery, The Rotterdam Eye Hospital, Rotterdam, the Netherlands.
authors.forename: Hanida
authors.initials: H
authors.lastname: Hanafi
authors.affiliation: Department of Pathology, ErasmusMC University Medical Center Rotterdam, Rotterdam, the Netherlands.
authors.forename: Rob M
authors.initials: RM
authors.lastname: Verdijk
authors.affiliation: Department of Oculoplastic and Orbital Surgery, The Rotterdam Eye Hospital, Rotterdam, the Netherlands.
authors.forename: Dion
authors.initials: D
authors.lastname: Paridaens
mesh_terms: D001706:Biopsy; D016190:Carboplatin / Q000627:therapeutic use; D059248:Chemoradiotherapy; D005134:Eye Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary* / Q000628:therapy; D005260:Female; D006801:Humans; D007766:Lacrimal Apparatus Diseases / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary* / Q000628:therapy; D008279:Magnetic Resonance Imaging; D008654:Mesothelioma / Q000000981:diagnostic imaging / Q000556:secondary* / Q000628:therapy; D000086002:Mesothelioma, Malignant; D008875:Middle Aged; D010997:Pleural Neoplasms / Q000473:pathology*
chemical_list: D016190:Carboplatin
keywords: chemo and radiotherapy; lacrimal gland; malignant mesothelioma; metastasis