title: Animal models of gastrointestinal and liver diseases. Animal models of acute and chronic pancreatitis.
abstract: Animal models of pancreatitis are useful for elucidating the pathogenesis of pancreatitis and developing and testing novel interventions. In this review, we aim to summarize the most commonly used animal models, overview their pathophysiology, and discuss their strengths and limitations. We will also briefly describe common animal study procedures and refer readers to more detailed protocols in the literature. Although animal models include pigs, dogs, opossums, and other animals, we will mainly focus on rodent models because of their popularity. Autoimmune pancreatitis and genetically engineered animal models will be reviewed elsewhere.
authors.affiliation: Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida and.
authors.forename: Xianbao
authors.initials: X
authors.lastname: Zhan
authors.affiliation: Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida and.
authors.forename: Fan
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida.
authors.forename: Yan
authors.initials: Y
authors.lastname: Bi
authors.affiliation: Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida and ji.baoan@mayo.edu.
authors.forename: Baoan
authors.initials: B
authors.lastname: Ji
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D018450:Disease Progression; D010179:Pancreas / Q000473:pathology / Q000503:physiopathology; D010195:Pancreatitis / Q000503:physiopathology* / Q000628:therapy*
keywords: fibrosis; inflammation; pancreatic disorder