title: The In Vitro Activity of Tigemonam: a Comparison with Other Antimicrobial Agents.
abstract: The activity of tigemonam was compared with that of aztreonam, cefuroxime, cephalexin, amoxicillin/clavulanate potassium, gentamicin, and ofloxacin, using an agar dilution method. Tigemonam was active against strains containing known betalactamases of Tern and Oxa types, but strains containing broad-spectrum (group IV) enzymes were less susceptible. The MIC90of tigemonam against the common Enterobacteriaceae was ≦ 0.25 mg/L. The MIC90S against Haemophilus influenzae and Neisseria gonorrhoeae were 0.5 and 0.06 mg/L, respectively. Pseudomonas, staphylococci, and Bacteroides sp. were less susceptible (MIC90> 128 mg/L). Protein binding in human serum was found to be 62.5%; the presence of serum had only a modest effect on the activity of tigemonam.
authors.affiliation: a Department of Medical Microbiology , Dudley Road Hospital , Birmingham , UK .
authors.forename: J M
authors.initials: JM
authors.lastname: Andrews
authors.affiliation: a Department of Medical Microbiology , Dudley Road Hospital , Birmingham , UK .
authors.forename: R
authors.initials: R
authors.lastname: Wise