title: Glutamate release and uptake processes are altered in a new mouse model of amyotrophic lateral sclerosis.
abstract: In this paper, we showed that in the cortex of mice expressing an abberant form of FUS protein that model amyotrophic lateral sclerosis (ALS), the processes of KCl-induced and basal [(3)H]glutamate release and uptake are altered at the presymptomatic stage as compared to the non-transgenic littermates. The change in these three parameters in transgenic animals causes excitotoxicity, which, in turn, may lead to massive loss of motor neurons and the onset of ALS symptoms.
authors.affiliation: Institute of Physiologically Active Compounds, Russian Academy of Sciences, Severnyi proezd 1, Chernogolovka, Moscow oblast, 142432, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Grigoriev
authors.affiliation: Institute of Physiologically Active Compounds, Russian Academy of Sciences, Severnyi proezd 1, Chernogolovka, Moscow oblast, 142432, Russia. efimova.a.d@gmail.com.
authors.forename: A D
authors.initials: AD
authors.lastname: Efimova
authors.affiliation: Institute of Physiologically Active Compounds, Russian Academy of Sciences, Severnyi proezd 1, Chernogolovka, Moscow oblast, 142432, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Ustyugov
authors.affiliation: Institute of Molecular Genetics, Russian Academy of Sciences, pl. Akademika Kurchatova 46, Moscow, 123182, Russia.
authors.forename: V P
authors.initials: VP
authors.lastname: Shevchenko
authors.affiliation: Institute of Physiologically Active Compounds, Russian Academy of Sciences, Severnyi proezd 1, Chernogolovka, Moscow oblast, 142432, Russia.
authors.forename: S O
authors.initials: SO
authors.lastname: Bachurin
authors.affiliation: Institute of Molecular Genetics, Russian Academy of Sciences, pl. Akademika Kurchatova 46, Moscow, 123182, Russia.
authors.forename: N F
authors.initials: NF
authors.lastname: Myasoedov
mesh_terms: D000375:Aging / Q000378:metabolism; D000690:Amyotrophic Lateral Sclerosis / Q000378:metabolism*; D000818:Animals; D002414:Cations, Monovalent / Q000378:metabolism; D002491:Central Nervous System Agents / Q000494:pharmacology; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D004195:Disease Models, Animal; D018698:Glutamic Acid / Q000378:metabolism*; D008822:Mice, Transgenic; D011188:Potassium / Q000378:metabolism; D011189:Potassium Chloride / Q000494:pharmacology; D034702:RNA-Binding Protein FUS / Q000235:genetics / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D013574:Synaptosomes / Q000378:metabolism; D014316:Tritium
chemical_list: D002414:Cations, Monovalent; D002491:Central Nervous System Agents; C000599551:FUS protein, mouse; D034702:RNA-Binding Protein FUS; D014316:Tritium; D018698:Glutamic Acid; D011189:Potassium Chloride; D012964:Sodium; D011188:Potassium