title: [Association between microRNA single nucleotide polymorphisms and the risk of hepatocellular carcinoma].
abstract: BACKGROUND
  Hepatocellular carcinoma (HCC) has a high morbidity and mortality. Single nucleotide polymorphisms (SNPs) of microRNA (miRNA) may be associated with the susceptibility to develop certain malignant tumors.
  
  
  OBJECTIVE
  To study the association between SNPs of miRNA and hepatocellular carcinoma in peripheral blood samples.
  
  
  METHODS
  Three SNPs in miRNA were studied in peripheral blood samples of 498 patients with HCC and 520 controls.
  
  
  RESULTS
  A significant association was observed between rs13299349 in miRNA3152 and HCC. AA genotype or A allele were significantly associated with increased risk of HCC. A allele was associated with the size and number of tumor foci. There was also a relationship between rs10061133 in miRNA449b and HCC. The G allele was significantly associated with increased risk of HCC compared with A allele.
  
  
  CONCLUSIONS
  This study links rs13299349 in miRNA3152 and rs10061133 in miRNA449b with the risk of developing HCC.
authors.forename: Wenshuai
authors.initials: W
authors.lastname: Li
authors.forename: Yanyun
authors.initials: Y
authors.lastname: Ma
authors.forename: Deqing
authors.initials: D
authors.lastname: Zeng
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.forename: Jingyi
authors.initials: J
authors.lastname: Hu
authors.forename: Dongqin
authors.initials: D
authors.lastname: Yang
authors.forename: Heping
authors.initials: H
authors.lastname: Hu
authors.forename: Jiucun
authors.initials: J
authors.lastname: Wang
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D014408:Biomarkers, Tumor; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies / Q000379:methods*; D020022:Genetic Predisposition to Disease; D060005:Genotyping Techniques; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012016:Reference Values; D012307:Risk Factors; D047368:Tumor Burden
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs