title: Hyaline-Vascular Type Castleman's Disease, Sarcoidosis, and Crohns Disease.
abstract: Sarcoidosis and Crohns disease have been associated with increased long term risk of lymphoproliferative disorders, including lymphomas. Newly developed lymphadenopathy in a patient with these disorders should prompt pathological evaluation. Castleman's disease is a lymphoproliferative disorder characterized by enlarged hyperplastic lymph nodes with regressed follicles surrounded by expanded mantle zones of small lymphocytes, and interfollicular vascular proliferation in the hyaline-vascular type. Similar to sarcoidosis and Crohns disease, its etiology is incompletely understood, although immune dysregulation, genetic factors and infectious and environmental factors are thought to play a role in all three diseases. Interleukin-6 is a possible pathological common factor between these three disease processed. Unicentric, hyaline-vascular type Castleman's disease can be treated successfully with complete surgical resection. We report a patient with long history of sarcoidosis and Crohns disease with newly developed lymphadenopathy which was found to be due to Castleman's disease.
authors.affiliation: Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX USA.
authors.forename: Arjun
authors.identifier: 0000-0003-0875-4731
authors.initials: A
authors.lastname: Gupta
authors.affiliation: Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX USA.
authors.forename: Balaji
authors.initials: B
authors.lastname: Ayyar
authors.affiliation: Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX USA.
authors.forename: Hamid
authors.initials: H
authors.lastname: Zia
authors.affiliation: Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX USA.
authors.forename: Weina
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Gastroenterology and Hepatology, University of Texas Southwestern Medical Center, Seay Biomedical Building, 2201 Inwood Road, Dallas, TX 75390-8562 USA.
authors.forename: Samar
authors.initials: S
authors.lastname: Harris
authors.affiliation: Department of Gastroenterology and Hepatology, University of Texas Southwestern Medical Center, Seay Biomedical Building, 2201 Inwood Road, Dallas, TX 75390-8562 USA ; Department of Hematology Oncology, University of Texas Southwestern Medical Center, Dallas, TX USA.
authors.forename: Harris V
authors.initials: HV
authors.lastname: Naina
keywords: Castleman’s disease; Crohns disease; Sarcoidosis; Surgical resection