title: FGFR3-TACC3 fusion in solid tumors: mini review.
abstract: Fibroblast growth factor receptors (FGFR) are transmembrane kinase proteins with growing importance in cancer biology given the frequency of molecular alterations and vast interface with multiple other signaling pathways. Furthermore, numerous FGFR inhibitors in clinical development demonstrate the expanding therapeutic relevance of this pathway. Indeed, results from early phase clinical trials already indicate that a subset of patients with advanced tumors derive benefit from FGFR targeted therapies. FGFR gene aberrations and FGFR gene rearrangements are relatively rare in solid malignancies. The recently described FGFR3-TACC3 fusion protein has a constitutively active tyrosine kinase domain and promotes aneuploidy. We summarize the prevalence data on FGFR3-TACC3 fusions among different histological tumor types and the preliminary evidence that this rearrangement represents a targetable molecular aberration in some patients with solid tumors.
authors.affiliation: Developmental Therapeutics Program, Division of Hematology and Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.|Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Costa
authors.affiliation: Developmental Therapeutics Program, Division of Hematology and Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.|Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.
authors.forename: Benedito A
authors.initials: BA
authors.lastname: Carneiro
authors.affiliation: Developmental Therapeutics Program, Division of Hematology and Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.|Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
authors.forename: Timothy
authors.initials: T
authors.lastname: Taxter
authors.affiliation: Department of Pathology, Messejana Heart and Lung Hospital, Fortaleza, Brazil.
authors.forename: Fabio A
authors.initials: FA
authors.lastname: Tavora
authors.affiliation: Developmental Therapeutics Program, Division of Hematology and Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.|Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.
authors.forename: Aparna
authors.initials: A
authors.lastname: Kalyan
authors.affiliation: Developmental Therapeutics Program, Division of Hematology and Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.|Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.
authors.forename: Sachin A
authors.initials: SA
authors.lastname: Pai
authors.affiliation: Developmental Therapeutics Program, Division of Hematology and Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.|Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.
authors.forename: Young Kwang
authors.initials: YK
authors.lastname: Chae
authors.affiliation: Developmental Therapeutics Program, Division of Hematology and Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.|Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.
authors.forename: Francis J
authors.initials: FJ
authors.lastname: Giles
mesh_terms: D000818:Animals; D050939:Gene Fusion; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D051498:Receptor, Fibroblast Growth Factor, Type 3 / Q000235:genetics*; D014178:Translocation, Genetic
chemical_list: D008869:Microtubule-Associated Proteins; C120551:TACC3 protein, human; C496365:FGFR3 protein, human; D051498:Receptor, Fibroblast Growth Factor, Type 3
keywords: FGFR3-TACC3 fusion; aneuploidy; glioblastoma multiforme; non-small cell lung cancer; phosphatidylinositol 3-Kinase (PI3K)