title: The use of hormonal agents in the treatment of acne.
abstract: Hormones and androgens play an important role in the pathogenesis of acne. Multiple hormonal modulators are now available for the treatment of acne. The efficacies and side effects of currently available hormonal agents are reviewed here including the use of oral contraceptives, spironolactone, flutamide, cyproterone acetate, finasteride, and cortexolone 17α-propionate. Hormonal therapies are an efficacious treatment option for acne among females. With the growing need to reduce antibiotic exposures, hormonal therapies should be more widely studied and incorporated into acne treatment strategies.
authors.affiliation: School of Medicine, University of California-Davis, Sacramento, California, USA.
authors.forename: Lauren A
authors.initials: LA
authors.lastname: Hassoun
authors.affiliation: School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.
authors.forename: Dev S
authors.initials: DS
authors.lastname: Chahal
authors.affiliation: Department of Dermatology, University of California-Davis, Sacramento, California, USA.
authors.forename: Raja K
authors.initials: RK
authors.lastname: Sivamani
authors.affiliation: Department of Dermatology, University of California-Davis, Sacramento, California, USA. lnlarsen@ucdavis.edu.
authors.forename: Larissa N
authors.initials: LN
authors.lastname: Larsen
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000284:Administration, Oral; D003270:Contraceptive Agents / Q000627:therapeutic use*; D003350:Cortodoxone / Q000031:analogs & derivatives / Q000627:therapeutic use; D017373:Cyproterone Acetate / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000627:therapeutic use*; D005260:Female; D018120:Finasteride / Q000627:therapeutic use; D005485:Flutamide / Q000627:therapeutic use; D006728:Hormones / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D015201:Meta-Analysis as Topic; D000451:Mineralocorticoid Receptor Antagonists / Q000627:therapeutic use; D011422:Propionates / Q000627:therapeutic use; D013148:Spironolactone / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D003270:Contraceptive Agents; D003879:Dermatologic Agents; D006728:Hormones; D000451:Mineralocorticoid Receptor Antagonists; D011422:Propionates; D013148:Spironolactone; D017373:Cyproterone Acetate; D018120:Finasteride; D005485:Flutamide; D003350:Cortodoxone; C496269:Clascoterone
keywords: acne; androgen; hormonal; oral contraceptive; sebum; spironolactone