title: Phytoecdysteroids-containing extract from Stachys hissarica plant and its wound-healing activity.
abstract: A number of phytoecdysteroid compounds, such as ecdysterone, polipodin V, 2-deoxy-20-hydroxyecdysone, integristeron A and 2-deoxydizon were isolated from Stachys hissarica plant and their structures were confirmed by NMR, mass and IR spectroscopy. In addition, the biological activity of the S. hissarica plant's extract was tested on rats for wound healing activity. It was shown that the extract at repeated oral (per os) administration at a dose of 10 mg/kg speeds up the healing process of linear skin wounds in rats. The wound-healing activity of S. hissarica extract is confirmed to be effective and exceeds known drug methyluracil (2,4-dioxo-6-methyl-1,2,3,4-tetrahydropyrimidine), especially in case of alloxan induced diabetic animals.
authors.affiliation: a Institute of the Chemistry of Plant Substances , Academy of Sciences of Uzbekistan , Tashkent , Uzbekistan.
authors.forename: Nurmurod Sh
authors.initials: NS
authors.lastname: Ramazanov
authors.affiliation: a Institute of the Chemistry of Plant Substances , Academy of Sciences of Uzbekistan , Tashkent , Uzbekistan.
authors.forename: Isomiddin D
authors.initials: ID
authors.lastname: Bobayev
authors.affiliation: a Institute of the Chemistry of Plant Substances , Academy of Sciences of Uzbekistan , Tashkent , Uzbekistan.
authors.forename: Ugiloy Y
authors.initials: UY
authors.lastname: Yusupova
authors.affiliation: b Department of Natural Sciences , Kokand State Pedagogical Institute , Kokand , Uzbekistan.
authors.forename: Namuna K
authors.initials: NK
authors.lastname: Aliyeva
authors.affiliation: a Institute of the Chemistry of Plant Substances , Academy of Sciences of Uzbekistan , Tashkent , Uzbekistan.
authors.forename: Feruza R
authors.initials: FR
authors.lastname: Egamova
authors.affiliation: a Institute of the Chemistry of Plant Substances , Academy of Sciences of Uzbekistan , Tashkent , Uzbekistan.
authors.forename: Nigora Kh
authors.initials: NK
authors.lastname: Yuldasheva
authors.affiliation: a Institute of the Chemistry of Plant Substances , Academy of Sciences of Uzbekistan , Tashkent , Uzbekistan.
authors.forename: Vladimir N
authors.initials: VN
authors.lastname: Syrov
mesh_terms: D000496:Alloxan; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology; D026461:Ecdysteroids / Q000494:pharmacology*; D010936:Plant Extracts / Q000032:analysis / Q000494:pharmacology*; D051381:Rats; D031366:Stachys / Q000737:chemistry*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D026461:Ecdysteroids; D010936:Plant Extracts; D000496:Alloxan
keywords: Phytoecdysteroids; Stachys hissarica; ecdysteron; extract; wound-healing activity