title: Primary liposarcoma of the pancreas: A review illustrated by findings from a recent case.
abstract: Liposarcoma is the most common soft tissue sarcoma and accounts for 15%-20% of all mesenchymal malignancies. The tumor occurs most frequently in limbs and retroperitoneum, with only rare instances of visceral location reported. Pancreas is a very rare site of primary liposarcoma, with a total of seven cases reported since 1979 and only four of those in the English literature. We review the literature specific for primary liposarcoma of the pancreas and discuss radiological and pathological aspects of this rare tumor type as well as emerging options of treatment. The review is illustrated by findings of a recent case of a dedifferentiated liposarcoma of the pancreas coupled with undifferentiated pleomorphic sarcoma, including the first description of this rare tumor by magnetic resonance imaging. The patient was successfully treated with distal pancreatectomy and splenectomy, followed by adjuvant chemotherapy and radiotherapy. At the 5-year follow-up, the patient showed no signs of recurrence.
authors.affiliation: Department of Clinical Emergencies, University of São Paulo School of Medicine, São Paulo 01409-001, Brazil. Electronic address: mccm37@uol.com.br.
authors.forename: Marcel Cerqueira Cesar
authors.initials: MC
authors.lastname: Machado
authors.affiliation: Digestive Surgery Division, Department of Gastroenterology, University of São Paulo School of Medicine, São Paulo 05403-900, Brazil.
authors.forename: Gilton Marques
authors.initials: GM
authors.lastname: Fonseca
authors.affiliation: Department of Pathology, Hospital Sírio-Libanês, São Paulo 01308-050, Brazil.
authors.forename: Luciana Rodrigues
authors.initials: LR
authors.lastname: de Meirelles
authors.affiliation: Fleury Laboratories, Department of Pathology, São Paulo 04344-070, Brazil.
authors.forename: Flavia Fernandes Silva
authors.initials: FF
authors.lastname: Zacchi
authors.affiliation: Department of Radiology, Hospital Sírio-Libanês and Instituto do Câncer do Estado de São Paulo-ICESP, São Paulo 01308-050, Brazil.
authors.forename: Regis Otaviano Franca
authors.initials: RO
authors.lastname: Bezerra
mesh_terms: D000328:Adult; D006801:Humans; D008080:Liposarcoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D009364:Neoplasm Recurrence, Local; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery
keywords: Dedifferentiated liposarcoma; Pancreatectomy; Pancreatic neoplasms