title: Assessment of Left Ventricular Structural Remodelling in Patients with Diabetic Cardiomyopathy by Cardiovascular Magnetic Resonance.
abstract: Background. Diabetic cardiomyopathy (DCM) is always accompanied with alteration of left ventricular structure and function. The aims of this study were to assess the structural remodelling in patients with DCM by cardiovascular magnetic resonance (CMR) and correlation of structural remodelling with severity of DCM. Methods. Twenty-five patients (53.8 ± 8.8 years, 52.0% males) with DCM and thirty-one normal healthy controls (51.9 ± 13.6 years, 45.2% males) were scanned by CMR cine to assess function and structure of left ventricular. Length of diabetic history and results of cardiac echocardiography (E', A', and E'/A') were also measured. Results. Compared with normal controls group, DCM group was associated with significantly increased ratio of left ventricular mass at end diastole to end-diastolic volume (MVR) (P < 0.05) and no significant difference was in mass at end diastole (P > 0.05). The ratio correlated with both length of diabetic history and echocardiographic Doppler tissue imaging E' (all P < 0.05). Conclusions. CMR can be a powerful technique to assess LV remodelling, and MVR may be considered as an imaging marker to evaluate the severity of LV remodelling in patients with DCM.
authors.affiliation: Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
authors.forename: Yongning
authors.identifier: 0000-0003-4244-3865
authors.initials: Y
authors.lastname: Shang
authors.affiliation: Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
authors.forename: Xiaochun
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
authors.forename: Liu
authors.identifier: 0000-0003-0966-2804
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Endocrinology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
authors.forename: Weiling
authors.initials: W
authors.lastname: Leng
authors.affiliation: Department of Endocrinology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
authors.forename: Xiaotian
authors.identifier: 0000-0001-5741-0607
authors.initials: X
authors.lastname: Lei
authors.affiliation: Department of Radiology, Xuanwu Hospital, Beijing 100053, China.
authors.forename: Qi
authors.identifier: 0000-0002-5773-0456
authors.initials: Q
authors.lastname: Yang
authors.affiliation: Department of Endocrinology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
authors.forename: Ziwen
authors.identifier: 0000-0002-9615-7381
authors.initials: Z
authors.lastname: Liang
authors.affiliation: Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
authors.forename: Jian
authors.identifier: 0000-0003-1210-0837
authors.initials: J
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D058065:Diabetic Cardiomyopathies / Q000000981:diagnostic imaging* / Q000209:etiology; D015150:Echocardiography, Doppler; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D008279:Magnetic Resonance Imaging; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D009025:Morpholines; D013318:Stroke Volume; D020257:Ventricular Remodeling
chemical_list: D009025:Morpholines; C003602:tiemonium iodide