title: Subchronic treatment with acai frozen pulp prevents the brain oxidative damage in rats with acute liver failure.
abstract: Acai has been used by the population due to its high nutritional value and its benefits to health, such as its antioxidant properties. The aim of this study was to evaluate the protective effect of acai frozen pulp on oxidative stress parameters in cerebral cortex, hippocampus and cerebellum of Wistar rats treated with carbon tetrachloride (CCl4). Thirty male Wistar rats (90-day-old) were orally treated with water or acai frozen pulp for 14 days (7 μL/g). On the 15th day, half of the animals received treatment with mineral oil and the other half with CCl4(3.0 mL/kg). The cerebral cortex, hippocampus and cerebellum were dissected and used for analysis of creatine kinase activity (CK), thiobarbituric acid reactive substances (TBARS), carbonyl, sulfhydryl, and the activity of antioxidant enzymes catalase (CAT) and superoxide dismutase (SOD). Statistical analysis was performed by ANOVA followed by Tukey's post-test. CCl4was able to inhibit CK activity in all tissues tested and to provoke lipid damage in cerebral cortex and cerebellum, and protein damage in the three tissues tested. CCl4enhanced CAT activity in the cerebral cortex, and inhibited CAT activity in the hippocampus and cerebellum and reduced SOD activity in all tissues studied. Acai frozen pulp prevented the inhibition of CK, TBARS, carbonyl and CAT activity in all brain structures and only in hippocampus for SOD activity. Therefore, acai frozen pulp has antioxidant properties and maybe could be useful in the treatment of some diseases that affect the central nervous system that are associated with oxidative damage.
authors.affiliation: Rua Coronel Joaquim Pedro Salgado, Centro Universitário Metodista - IPA, 80 - Rio Branco, Porto Alegre, RS, 90420-060, Brazil.
authors.forename: Fernanda
authors.initials: F
authors.lastname: de Souza Machado
authors.affiliation: Rua Coronel Joaquim Pedro Salgado, Centro Universitário Metodista - IPA, 80 - Rio Branco, Porto Alegre, RS, 90420-060, Brazil.
authors.forename: Jonnsin
authors.initials: J
authors.lastname: Kuo
authors.affiliation: Rua Coronel Joaquim Pedro Salgado, Centro Universitário Metodista - IPA, 80 - Rio Branco, Porto Alegre, RS, 90420-060, Brazil.
authors.forename: Mariane Farias
authors.initials: MF
authors.lastname: Wohlenberg
authors.affiliation: Rua Coronel Joaquim Pedro Salgado, Centro Universitário Metodista - IPA, 80 - Rio Branco, Porto Alegre, RS, 90420-060, Brazil.
authors.forename: Marina
authors.initials: M
authors.lastname: da Rocha Frusciante
authors.affiliation: Rua Coronel Joaquim Pedro Salgado, Centro Universitário Metodista - IPA, 80 - Rio Branco, Porto Alegre, RS, 90420-060, Brazil.
authors.forename: Márcia
authors.initials: M
authors.lastname: Freitas
authors.affiliation: Rua Coronel Joaquim Pedro Salgado, Centro Universitário Metodista - IPA, 80 - Rio Branco, Porto Alegre, RS, 90420-060, Brazil.
authors.forename: Alice S
authors.initials: AS
authors.lastname: Oliveira
authors.affiliation: Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600, anexo, Porto Alegre, RS, 90035-003, Brazil.
authors.forename: Rodrigo B
authors.initials: RB
authors.lastname: Andrade
authors.affiliation: Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600, anexo, Porto Alegre, RS, 90035-003, Brazil.
authors.forename: Clovis M D
authors.initials: CM
authors.lastname: Wannmacher
authors.affiliation: Rua Coronel Joaquim Pedro Salgado, Centro Universitário Metodista - IPA, 80 - Rio Branco, Porto Alegre, RS, 90420-060, Brazil.
authors.forename: Caroline
authors.initials: C
authors.lastname: Dani
authors.affiliation: Rua Coronel Joaquim Pedro Salgado, Centro Universitário Metodista - IPA, 80 - Rio Branco, Porto Alegre, RS, 90420-060, Brazil. claudia.funchal@metodistadosul.edu.br.
authors.forename: Claudia
authors.identifier: 0000-0001-5781-0475
authors.initials: C
authors.lastname: Funchal
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D065748:Euterpe; D005615:Freezing; D005638:Fruit; D017114:Liver Failure, Acute / Q000378:metabolism* / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology*; D010936:Plant Extracts / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D010936:Plant Extracts; D017392:Thiobarbituric Acid Reactive Substances
keywords: Acai; Antioxidants; Brain; Euterpe oleracea Mart; Neuroprotection; Oxidative stress