title: Clinical experience of unexpected findings in prenatal array testing.
abstract: OBJECTIVE
  The aim of this study was to evaluate whether unexpected diagnoses (UD) made by prenatal array testing contribute to pregnancy management.
  
  
  METHODS
  In 2010-2015 in 19/4043 (0.5%) pregnancies an UD was made. The clinical usefulness of UDs was assessed based on the couple's responses during post-test counseling and their decisions.
  
  
  RESULTS
  In 16/19 cases, the UD was helpful either for the couples in making a decision about the course of their pregnancy, for perinatal management or family genetic counseling.
  
  
  CONCLUSIONS
  The majority of the pregnant couples found the UDs relevant for pregnancy management and genetic counseling. This adds another motive for offering whole genome array during pregnancy in patients who wish broad testing of their fetus.
authors.affiliation: Department of Clinical Genetics, Erasmus Medical Center, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands.
authors.forename: Marieke
authors.initials: M
authors.lastname: Joosten
authors.affiliation: Department of Clinical Genetics, Erasmus Medical Center, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands.
authors.forename: Karin Em
authors.initials: KE
authors.lastname: Diderich
authors.affiliation: Department of Clinical Genetics, Erasmus Medical Center, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands.
authors.forename: Diane
authors.initials: D
authors.lastname: Van Opstal
authors.affiliation: Department of Clinical Genetics, Erasmus Medical Center, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands.
authors.forename: Lutgarde Cp
authors.initials: LC
authors.lastname: Govaerts
authors.affiliation: Department of Clinical Genetics, Erasmus Medical Center, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands.
authors.forename: Sam R
authors.initials: SR
authors.lastname: Riedijk
authors.affiliation: Department of Obstetrics & Gynecology, Erasmus Medical Center, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands.
authors.forename: A Krista E
authors.initials: AK
authors.lastname: Prinsen
authors.affiliation: Department of Clinical Genetics, Erasmus Medical Center, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands.
authors.forename: Femke At
authors.initials: FA
authors.lastname: De Vries
authors.affiliation: Department of Obstetrics & Gynecology, Erasmus Medical Center, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands.
authors.forename: Attie Tji
authors.initials: AT
authors.lastname: Go
authors.affiliation: Department of Clinical Genetics, Erasmus Medical Center, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands.
authors.forename: Robert-Jan H
authors.initials: RJ
authors.lastname: Galjaard
authors.affiliation: Department of Clinical Genetics, Erasmus Medical Center, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands.
authors.forename: Malgorzata I
authors.initials: MI
authors.lastname: Srebniak
mesh_terms: D056915:DNA Copy Number Variations; D004314:Down Syndrome / Q000175:diagnosis / Q000235:genetics; D005260:Female; D005817:Genetic Counseling; D015894:Genome, Human; D005865:Gestational Age; D006330:Heart Defects, Congenital / Q000175:diagnosis / Q000235:genetics; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014463:Ultrasonography
keywords: array; incidental findings; post-test counseling; prenatal diagnosis; pretest counseling; unexpected diagnosis