title: Comparative Study between the Surgeon's Intraoperative Evaluation and Histopathology for Diagnosis of Laryngeal Lesions.
abstract: Objective. To compare the surgeon's evaluation and histopathology for diagnosis of laryngeal lesions. Material. A clinical survey was distributed to laryngeal surgeons, ENT clinicians, and students in 2013 at the Department of Otorhinolaryngology in Rostock. Participants were asked to anonymously identify laryngeal pathologies and to assess the severity of the lesion starting from hyperplasia and inflammation over moderate dysplasia to early laryngeal cancer. Images of similar clinical laryngeal lesions were demonstrated in a multiple-choice modus to assess the surgeon's intraoperative evaluation. The questionnaires were digitally processed and evaluated. The results were correlated with histopathology and compared between experienced laryngeal surgeons, clinicians inexperienced in laryngeal surgery, and medical students from the Medical Faculty of the University of Rostock. Results. Sensitivity and specificity varied among the various groups, being highest in experienced laryngeal surgeons. In this group, sensitivity, specificity, positive and negative predictive value, and accuracy were 85%, 56%, 44%, 90%, and 65%, respectively. In 4% and 31%, laryngeal disease was underdiagnosed and overdiagnosed, respectively. In this group, Kappa statistics resulted in Kappa 0.32 (P < 0.001). Conclusion. This clinical survey clearly demonstrates that conformity between histopathology and evaluation of the laryngeal lesion depends on the surgeon's experience.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University of Rostock, Doberaner Straße 137-139, 18057 Rostock, Germany.
authors.forename: Benjamin
authors.identifier: 0000-0002-0681-668X
authors.initials: B
authors.lastname: von Stülpnagel
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University of Rostock, Doberaner Straße 137-139, 18057 Rostock, Germany.
authors.forename: Robert
authors.initials: R
authors.lastname: Hagen
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University of Rostock, Doberaner Straße 137-139, 18057 Rostock, Germany.
authors.forename: Bernhard
authors.identifier: 0000-0001-6723-3587
authors.initials: B
authors.lastname: Olzowy
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University of Rostock, Doberaner Straße 137-139, 18057 Rostock, Germany.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Witt
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University of Rostock, Doberaner Straße 137-139, 18057 Rostock, Germany.
authors.forename: Hans Wilhelm
authors.initials: HW
authors.lastname: Pau
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University of Rostock, Doberaner Straße 137-139, 18057 Rostock, Germany.
authors.forename: Tino
authors.initials: T
authors.lastname: Just