title: Impact of HIV-1 Subtypes on AIDS Progression in a Brazilian Cohort.
abstract: Viral and host factors are known to play a role in the different patterns of AIDS progression. The cocirculation of HIV-1 subtypes B, F1, BBR, and BF1; the occasional detection of HIV-1 subtype D; and an increasing prevalence of subtype C and other recombinant forms have been described in Rio de Janeiro, Brazil. The aim of this study was to evaluate the potential association of HIV-1 subtypes circulating among HIV-1+ individuals in Rio de Janeiro with AIDS disease progression. For this purpose, 246 HIV-1 individuals under clinical and laboratory follow-up from 1986 to 2011 were classified according to their progression to AIDS in typical progressors (n = 133), rapid progressors (n = 95), and long-term nonprogressors (n = 18). The env-gp120 region was amplified and sequenced. Neighbor-joining phylogenetic inferences were performed in Mega 6 and bootscan analysis was performed in Simplot 3.5.1. The Kaplan-Meier method and Cox modeling were performed to determine the time until an AIDS-defining event based on the HIV-1 subtypes/variants. Similar AIDS progression rates were observed among individuals infected with HIV-1 subtype B and variant BBR. However, a direct association between more rapid AIDS progression and HIV-1 subtypes, D and BF1, was confirmed in the multivariate analysis, corroborating previous results. Our findings contribute to the investigation of the possible influence of HIV-1 subtypes in AIDS outcome.
authors.affiliation: 1 Laboratory of AIDS and Molecular Immunology, Oswaldo Cruz Institute , FIOCRUZ, Rio de Janeiro, Brazil .
authors.forename: Thaysse Cristina Neiva Ferreira
authors.initials: TC
authors.lastname: Leite
authors.affiliation: 2 Evandro Chagas Nacional Institute of Infectious Diseases , FIOCRUZ, Rio de Janeiro, Brazil .
authors.forename: Dayse Pereira
authors.initials: DP
authors.lastname: Campos
authors.affiliation: 2 Evandro Chagas Nacional Institute of Infectious Diseases , FIOCRUZ, Rio de Janeiro, Brazil .
authors.forename: Alessandra Brum
authors.initials: AB
authors.lastname: Coelho
authors.affiliation: 1 Laboratory of AIDS and Molecular Immunology, Oswaldo Cruz Institute , FIOCRUZ, Rio de Janeiro, Brazil .
authors.forename: Sylvia Lopes Maia
authors.initials: SL
authors.lastname: Teixeira
authors.affiliation: 2 Evandro Chagas Nacional Institute of Infectious Diseases , FIOCRUZ, Rio de Janeiro, Brazil .
authors.forename: Valdilea
authors.initials: V
authors.lastname: Veloso
authors.affiliation: 1 Laboratory of AIDS and Molecular Immunology, Oswaldo Cruz Institute , FIOCRUZ, Rio de Janeiro, Brazil .
authors.forename: Mariza Gonçalves
authors.initials: MG
authors.lastname: Morgado
authors.affiliation: 1 Laboratory of AIDS and Molecular Immunology, Oswaldo Cruz Institute , FIOCRUZ, Rio de Janeiro, Brazil .
authors.forename: Monick Lindenmeyer
authors.initials: ML
authors.lastname: Guimarães
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000473:pathology* / Q000821:virology*; D000328:Adult; D056808:Biostatistics; D001938:Brazil; D016000:Cluster Analysis; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D015699:HIV Envelope Protein gp120 / Q000235:genetics; D015497:HIV-1 / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D055815:Young Adult
chemical_list: D015699:HIV Envelope Protein gp120; C514793:gp120 protein, Human immunodeficiency virus 1
keywords: AIDS progression; HIV-1; subtypes