title: Functionalized Magnetic Fe3O4-β-Cyclodextran Nanoparticles for Efficient Removal of Bilirubin.
abstract: Bilirubin (BR), as a lipophilic toxin, can binds and deposits in various tissues, especially the brain tissue, leading to hepatic coma and even death. Magnetic nanoparticles adsorbent modified by β-cyclodextran (Fe3O4-β-CD) was developed to remove the BR from the plasma. Fe3O4-β-CD nanoparticles was prepared through Schiff base reaction between the polyethylenimine (PEI)-modified Fe3O4 and aldehyde-functionalized β-CD, and characterized by Fourier transform infrared (FTIR) spectra, X-ray diffraction (XRD), transmission electron microscopy (TEM), vibrating sample magnetometer (VSM) and dynamic light scattering (DLS). Under optimized conditions, the Fe3O4-β-CD adsorbent could adsorb 225.6 mg/g free BR in PBS and reach the adsorption equilibrium within 90 min mainly through hydrophobic interaction; Moreover, the adsorbent displayed better adsorption capability in a dialysis system for BSA-bound bilirubin, plasma bilirubin and total bile acid, and the removal rates of those were 66%, 31% and 41% respectively. Because of the advantages of fast separation and purification process, low preparation cost, good adsorption capability for plasma bilirubin, Fe3O4-β-CD may become an economical and promising absorbent of BR for clinical applications.
authors.forename: Lulu
authors.initials: L
authors.lastname: Han
authors.forename: Simin
authors.initials: S
authors.lastname: Chu
authors.forename: Houliang
authors.initials: H
authors.lastname: Wei
authors.forename: Jun
authors.initials: J
authors.lastname: Ren
authors.forename: Li
authors.initials: L
authors.lastname: Xu
authors.forename: Lingyun
authors.initials: L
authors.lastname: Jia
mesh_terms: D000327:Adsorption; D000818:Animals; D001663:Bilirubin / Q000737:chemistry* / Q000302:isolation & purification* / Q000378:metabolism; D002417:Cattle; D003956:Dialysis; D006801:Humans; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D012709:Serum Albumin / Q000378:metabolism; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D058185:Magnetite Nanoparticles; D012709:Serum Albumin; D047392:beta-Cyclodextrins; D001663:Bilirubin