title: Single-step scaffold-based cartilage repair in the knee: A systematic review.
abstract: Chondral lesions are difficult-to-treat entities that often affect young and active people. Moreover, cartilage has limited intrinsic healing potential. The purpose of this systematic literature review was to analyse whether the single-step scaffold-based cartilage repair in combination with microfracturing (MFx) is more effective and safe in comparison to MFx alone. From the three identified studies, it seems that the single-step scaffold-assisted cartilage repair in combination with MFx leads to similar short- to medium-term (up to five years follow-up) results, compared to MFx alone. All of the studies have shown improvements regarding joint functionality, pain and partly quality of life.
authors.affiliation: Ludwig Boltzmann Institute for Health Technology Assessment, Garnisongasse 7/20, 1090 Vienna, Austria.
authors.forename: Stefan
authors.initials: S
authors.lastname: Fischer
authors.affiliation: Ludwig Boltzmann Institute for Health Technology Assessment, Garnisongasse 7/20, 1090 Vienna, Austria.
authors.forename: Agnes
authors.initials: A
authors.lastname: Kisser
keywords: Autologous chondrocyte implantation; Cartilage defects; Chondrogenesis; Matrix-assisted cartilage repair; Microfracturing