title: A case of intraparotid schwannoma in a juvenile: Clinical, pathological, ultrastructural, and immunohistopathological study, including an examination of Ki-67 and MCM-3 expressions.
abstract: Pleomorphic adenoma, the most common benign nonvascular tumor of the parotid gland in juveniles, should be differentiated from other extremely rare tumors, including schwannoma. In this article, we present a rare case of an intraparotid schwannoma in a juvenile, along with the patient history, a description of pathological features, and the results of ultrastructural and immunohistochemical examination. The respective labeling indexes of Ki-67 and MCM-3, i.e., the mean proportions of positive tumor cells out of 1000 tumoral cells counted in 10 microscopic fields at ×400 magnification, given as a percentage, were found to be 0.82% and 0.4%, respectively.
authors.affiliation: a Department of Pediatric Otorhinolaryngology , Medical University of Lodz , Lodz , Poland.
authors.forename: Rafal
authors.initials: R
authors.lastname: Zielinski
authors.affiliation: b Department of Pathology, Central Clinical Hospital , Medical University of Lodz , Lodz , Poland.
authors.forename: Jozef
authors.initials: J
authors.lastname: Kobos
authors.affiliation: a Department of Pediatric Otorhinolaryngology , Medical University of Lodz , Lodz , Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Zakrzewska
mesh_terms: D000293:Adolescent; D014408:Biomarkers, Tumor / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis / Q000096:biosynthesis; D008297:Male; D046529:Microscopy, Electron, Transmission; D064126:Minichromosome Maintenance Complex Component 3 / Q000032:analysis / Q000096:biosynthesis; D009442:Neurilemmoma / Q000175:diagnosis* / Q000473:pathology / Q000648:ultrastructure; D010307:Parotid Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000648:ultrastructure
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; C066470:MCM3 protein, human; D064126:Minichromosome Maintenance Complex Component 3
keywords: Intraparotid; Ki-67; MCM-3; juvenile; schwannoma