title: Role of Soluble Interleukin-6 Receptor With Interleukin-6 in Human Hematopoiesis.
abstract: A complex of soluble interleukin-6 receptor (sIL-6R) and interleukin-6 has been shown to play some roles in human hematopoiesis. It activates gp130 signal to stimulate human erythroid, megakaryocytic and primitive hematopoietic progenitor cells, which express gp130 but not IL-6R, in the presence of c-Kit signal mediated by stem cell factor (SCF). The culture system using a combination of sIL-6R, IL-6 and SCF can be useful for ex vivo expansion of human hematopoietic stem/progenitor cells and provide a novel way for gene transfer into human hematopoietic stem cells.
authors.affiliation: a Department of Clinical Oncology , The Institute of Medical Science, The University of Tokyo , 4-6-1 Shirokanedai, Minato -ku, Tokyo 108, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Tsuji
authors.affiliation: a Department of Clinical Oncology , The Institute of Medical Science, The University of Tokyo , 4-6-1 Shirokanedai, Minato -ku, Tokyo 108, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nakahata
keywords: Interleukin-6; Soluble interleukin-6 receptor; c-Kit; gp130; stem cell factor