title: Higher blood MLL1 mRNA and BDNF promoter IV on histone H3K4me3 levels in patients with schizophrenia.
abstract: We investigated the blood levels of mixed-lineage leukemia 1 (MLL1) mRNA and BDNF (brain derived neurotrophic factor) exon IV promoter on histone Histone 3 lysine 4 trimethylation (H3K4me3) in peripheral blood of patients with schizophrenia and controls. Over one year, 36 patients with schizophrenia and 32 controls were recruited. Psychiatric diagnoses were made based on DSM-IV criteria. Higher blood MLL1 mRNA and BDNF exon IV promoter on H3K4me3 levels were noted in patients with schizophrenia than in controls. The results showed that blood MLL1 mRNA and BDNF exon IV on H3K4me3 levels might be involved in the psychopathology of schizophrenia.
authors.affiliation: Department of Psychiatry, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan. Electronic address: a540520@adm.cgmh.com.tw.
authors.forename: Tiao-Lai
authors.initials: TL
authors.lastname: Huang
authors.affiliation: Department of Psychiatry, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
authors.forename: Chin-Chuen
authors.initials: CC
authors.lastname: Lin
authors.affiliation: Department of Medical Research & Development, Show Chwan Memorial Hospital, Chang Bing, Changhua 505, Taiwan.
authors.forename: Rong-Fu
authors.initials: RF
authors.lastname: Chen
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
authors.forename: Chien-Te
authors.initials: CT
authors.lastname: Lee
mesh_terms: D000328:Adult; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood* / Q000235:genetics; D005091:Exons; D005260:Female; D011495:Histone-Lysine N-Methyltransferase / Q000097:blood* / Q000235:genetics; D006657:Histones / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D051788:Myeloid-Lymphoid Leukemia Protein / Q000097:blood* / Q000235:genetics; D011401:Promoter Regions, Genetic; D012333:RNA, Messenger; D012559:Schizophrenia / Q000097:blood* / Q000235:genetics
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D006657:Histones; C497422:KMT2A protein, human; D012333:RNA, Messenger; D051788:Myeloid-Lymphoid Leukemia Protein; C579455:BDNF protein, human; D011495:Histone-Lysine N-Methyltransferase
keywords: BDNF; H3K4me3; MLL1; Schizophrenia