title: Completeness of required site-specific factors for brain and CNS tumors in the Surveillance, Epidemiology and End Results (SEER) 18 database (2004-2012, varying).
abstract: Cancer registries are an important source of population-level information on brain tumor incidence and survival. Surveillance, Epidemiology, and End Results (SEER) registries currently collect data on specific required factors related to brain tumors as defined by the American Joint Commission on Cancer, including World Health Organization (WHO) grade, MGMT methylation and 1p/19q codeletion status. We assessed 'completeness', defined as having valid values over the time periods that they have been collected, overall, by year, histology, and registry. Data were obtained through a SEER custom data request for four factors related to brain tumors for the years 2004-2012 (3/4 factors were collected only from 2010 to 2012). SEER*Stat was used to generate frequencies of 'completeness' for each factor overall, and by year, histology and registry. The four factors varied in completeness, but increased over time. WHO grade has been collected the longest, and showed significant increases in completeness. Completeness of MGMT and 1p/19q codeletion was highest for glioma subtypes for which testing is recommended by clinical practice guidelines. Completeness of all factors varied by histology and cancer registry. Overall, several of the factors had high completeness, and all increased in completeness over time. With increasing focus on 'precision medicine' and the incorporation of molecular parameters into the 2016 WHO CNS tumor classification, it is critical that the data are complete, and factors collected at the population level are fully integrated into cancer reporting. It is critical that cancer registries continue to collect established and emerging prognostic and predictive factors.
authors.affiliation: Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Wearn 152, Cleveland, OH, 44106, USA.|Central Brain Tumor Registry of the United States (CBTRUS), Hinsdale, IL, USA.
authors.forename: Quinn T
authors.initials: QT
authors.lastname: Ostrom
authors.affiliation: Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Wearn 152, Cleveland, OH, 44106, USA.|Central Brain Tumor Registry of the United States (CBTRUS), Hinsdale, IL, USA.
authors.forename: Haley
authors.initials: H
authors.lastname: Gittleman
authors.affiliation: Central Brain Tumor Registry of the United States (CBTRUS), Hinsdale, IL, USA.
authors.forename: Carol
authors.initials: C
authors.lastname: Kruchko
authors.affiliation: Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: David N
authors.initials: DN
authors.lastname: Louis
authors.affiliation: Department of Pathology and Laboratory Medicine, Winship Cancer Institute of Emory University, Atlanta, GA, USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Brat
authors.affiliation: Neuro-Oncology Branch, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Mark R
authors.initials: MR
authors.lastname: Gilbert
authors.affiliation: Surveillance Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA.
authors.forename: Valentina I
authors.initials: VI
authors.lastname: Petkov
authors.affiliation: Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Wearn 152, Cleveland, OH, 44106, USA. jsb42@case.edu.|Central Brain Tumor Registry of the United States (CBTRUS), Hinsdale, IL, USA. jsb42@case.edu.
authors.forename: Jill S
authors.initials: JS
authors.lastname: Barnholtz-Sloan
mesh_terms: D016543:Central Nervous System Neoplasms / Q000145:classification / Q000453:epidemiology / Q000235:genetics; D002872:Chromosome Deletion; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics*; D019175:DNA Methylation; D015254:DNA Modification Methylases / Q000235:genetics* / Q000378:metabolism; D045643:DNA Repair Enzymes / Q000235:genetics* / Q000378:metabolism; D016208:Databases, Factual / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D011379:Prognosis; D062486:Public Health Surveillance; D012042:Registries / Q000706:statistics & numerical data; D012189:Retrospective Studies; D018426:SEER Program / Q000706:statistics & numerical data*; D025521:Tumor Suppressor Proteins / Q000235:genetics* / Q000378:metabolism; D014481:United States / Q000453:epidemiology
chemical_list: D025521:Tumor Suppressor Proteins; D015254:DNA Modification Methylases; C515491:MGMT protein, human; D045643:DNA Repair Enzymes
keywords: 1p/19q codeletion; Brain tumors; Cancer registration; MGMT methylation; WHO grade