title: A case of TAFRO syndrome, a variant of multicentric Castleman's disease, successfully treated with corticosteroid and cyclosporine A.
abstract: We report a case of a 46-year-old woman with fever, pleural effusion, massive ascites, severe edema, hepatosplenomegaly, elevation of serum creatinine level, proteinuria, and severe thrombocytopenia. Her clinical features were compatible with TAFRO syndrome proposed as a variant of multicentric Castleman's disease, that is occasionally associated with poor prognosis. Treatment with corticosteroid improved her symptoms partially. However, thrombocytopenia, ascites, and edema persisted. The use of cyclosporine A successfully improved her condition, resulting in remission.
authors.affiliation: a Department of Internal Medicine , NTT East Tohoku Hospital , Sendai , Japan and.|b Department of Rheumatology , NTT East Tohoku Hospital , Sendai , Japan.
authors.forename: Naruhiko
authors.initials: N
authors.lastname: Takasawa
authors.affiliation: a Department of Internal Medicine , NTT East Tohoku Hospital , Sendai , Japan and.|b Department of Rheumatology , NTT East Tohoku Hospital , Sendai , Japan.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Sekiguchi
authors.affiliation: a Department of Internal Medicine , NTT East Tohoku Hospital , Sendai , Japan and.
authors.forename: Tsuneyuki
authors.initials: T
authors.lastname: Takahashi
authors.affiliation: a Department of Internal Medicine , NTT East Tohoku Hospital , Sendai , Japan and.
authors.forename: Akira
authors.initials: A
authors.lastname: Muryoi
authors.affiliation: a Department of Internal Medicine , NTT East Tohoku Hospital , Sendai , Japan and.
authors.forename: Jo
authors.initials: J
authors.lastname: Satoh
authors.affiliation: a Department of Internal Medicine , NTT East Tohoku Hospital , Sendai , Japan and.|b Department of Rheumatology , NTT East Tohoku Hospital , Sendai , Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sasaki
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use*; D005871:Castleman Disease / Q000175:diagnosis / Q000188:drug therapy*; D016572:Cyclosporine / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged
chemical_list: D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents; D016572:Cyclosporine
keywords: Corticosteroid; Cyclosporine A; Multicentric Castleman’s disease; TAFRO syndrome