title: (1)H-MRS and MEGA-PRESS pulse sequence in the study of balance of inhibitory and excitatory neurotransmitters in the human brain of ultra-high risk of schizophrenia patients.
abstract: The MEGA-PRESS pulse sequence was used for determination of overlapping signals in the (1)H-MRS spectra of the human brain. For the first time, the balance of GABA glutamate/glutamine concentrations was estimated quantitatively in the human brain of patients with ultra-high risk of schizophrenia. It was found that GABA concentration and GABA/GLX ratios were significantly reduced in the left frontal lobe of UHR subjects.
authors.affiliation: Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosygina 4, Moscow, 117977, Russia. peeterem@gmail.com.
authors.forename: P E
authors.initials: PE
authors.lastname: Menschikov
authors.affiliation: Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosygina 4, Moscow, 117977, Russia.|Research Institute of Emergency Children's Surgery and Trauma, Bol'shaya Polyanka 22, Moscow, 119180, Russia.|Semenov Institute of Chemical Physics, Russian Academy of Sciences, ul. Kosygina 4, Moscow, 119991, Russia.
authors.forename: N A
authors.initials: NA
authors.lastname: Semenova
authors.affiliation: Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosygina 4, Moscow, 117977, Russia.|Research Institute of Emergency Children's Surgery and Trauma, Bol'shaya Polyanka 22, Moscow, 119180, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Ublinskiy
authors.affiliation: Research Institute of Emergency Children's Surgery and Trauma, Bol'shaya Polyanka 22, Moscow, 119180, Russia.
authors.forename: T A
authors.initials: TA
authors.lastname: Akhadov
authors.affiliation: Research Institute of Emergency Children's Surgery and Trauma, Bol'shaya Polyanka 22, Moscow, 119180, Russia.
authors.forename: R A
authors.initials: RA
authors.lastname: Keshishyan
authors.affiliation: Scientific Center of Mental Health, Moscow, Russia.
authors.forename: I S
authors.initials: IS
authors.lastname: Lebedeva
authors.affiliation: Scientific Center of Mental Health, Moscow, Russia.
authors.forename: M A
authors.initials: MA
authors.lastname: Omelchenko
authors.affiliation: Scientific Center of Mental Health, Moscow, Russia.
authors.forename: V G
authors.initials: VG
authors.lastname: Kaleda
authors.affiliation: Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosygina 4, Moscow, 117977, Russia.
authors.forename: S D
authors.initials: SD
authors.lastname: Varfolomeev
mesh_terms: D000293:Adolescent; D000328:Adult; D003401:Creatine / Q000378:metabolism; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000378:metabolism*; D007839:Functional Laterality; D018698:Glutamic Acid / Q000378:metabolism*; D005973:Glutamine / Q000378:metabolism*; D006801:Humans; D008297:Male; D062706:Prodromal Symptoms; D066244:Proton Magnetic Resonance Spectroscopy / Q000379:methods*; D012306:Risk; D012559:Schizophrenia / Q000000981:diagnostic imaging / Q000378:metabolism*; D055815:Young Adult; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D005973:Glutamine; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D003401:Creatine