title: Evaluation of Pressure Stable Chip-to-Tube Fittings Enabling High-Speed Chip-HPLC with Mass Spectrometric Detection.
abstract: Appropriate chip-to-tube interfacing is an enabling technology for high-pressure and high-speed liquid chromatography on chip. For this purpose, various approaches, to connect pressure resistant glass chips with HPLC pumps working at pressures of up to 500 bar, were examined. Three side-port and one top-port connection approach were evaluated with regard to pressure stability and extra column band broadening. A clamp-based top-port approach enabled chip-HPLC-MS analysis of herbicides at the highest pressure and speed.
authors.affiliation: Institute of Analytical Chemistry, University of Leipzig , Linnéstraße 3, 04103 Leipzig, Germany.
authors.forename: Carsten
authors.initials: C
authors.lastname: Lotter
authors.affiliation: Institute of Analytical Chemistry, University of Leipzig , Linnéstraße 3, 04103 Leipzig, Germany.
authors.forename: Josef J
authors.initials: JJ
authors.lastname: Heiland
authors.affiliation: Fraunhofer ICT-IMM , Carl-Zeiss-Str. 18-20, 55129 Mainz, Germany.
authors.forename: Volkmar
authors.initials: V
authors.lastname: Stein
authors.affiliation: Institute of Analytical Chemistry, University of Leipzig , Linnéstraße 3, 04103 Leipzig, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Klimkait
authors.affiliation: Fraunhofer IZM , Gustav-Meyer-Allee 25, 13355 Berlin, Germany.
authors.forename: Marco
authors.initials: M
authors.lastname: Queisser
authors.affiliation: Institute of Analytical Chemistry, University of Leipzig , Linnéstraße 3, 04103 Leipzig, Germany.
authors.forename: Detlev
authors.initials: D
authors.lastname: Belder