title: Diagnostic value of intestinal fatty acid-binding protein for pneumatosis intestinalis.
abstract: BACKGROUND
  Pneumatosis intestinalis (PI) is known as a sign of a life-threatening bowel ischemia. We aimed to evaluate the utility of intestinal fatty acid-binding protein (I-FABP) in the diagnosis of pathologic PI.
  
  
  METHODS
  All consecutive patients who presented to our emergency department with PI were prospectively enrolled. The diagnostic performance of I-FABP for pathologic PI was compared with that of other traditional biomarkers and various parameters.
  
  
  RESULTS
  Seventy patients with PI were enrolled. Pathologic PI was diagnosed in 27 patients (39%). The levels of most biomarkers were significantly higher in patients with pathologic PI than those with nonpathologic PI (P < .05). Receiver operator characteristic analysis revealed that the area under the curve (AUC) was highest for I-FABP (area under the curve = .82) in the diagnosis of pathologic PI.
  
  
  CONCLUSIONS
  High I-FABP value, in combination with other parameters, might be clinically useful for pathologic PI.
authors.affiliation: Department of Trauma and Emergency Surgery, Saiseikai Yokohamashi Tobu Hospital, 3-6-1 Shimosueyoshi, Tsurumi-ku, Yokohama-shi, Kanagawa 230-0012, Japan. Electronic address: m-shokei@feel.ocn.ne.jp.
authors.forename: Shokei
authors.initials: S
authors.lastname: Matsumoto
authors.affiliation: Department of Emergency Medicine, Saiseikai Central Hospital, Tokyo, Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Sekine
authors.affiliation: Division of Research and Development, DS Pharma Biomedical Co., Ltd., Osaka, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Funaoka
authors.affiliation: Department of Trauma and Emergency Surgery, Saiseikai Yokohamashi Tobu Hospital, 3-6-1 Shimosueyoshi, Tsurumi-ku, Yokohama-shi, Kanagawa 230-0012, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Funabiki
authors.affiliation: Department of Trauma and Emergency Surgery, Saiseikai Yokohamashi Tobu Hospital, 3-6-1 Shimosueyoshi, Tsurumi-ku, Yokohama-shi, Kanagawa 230-0012, Japan.
authors.forename: Motoyasu
authors.initials: M
authors.lastname: Yamazaki
authors.affiliation: Department of Trauma and Emergency Surgery, Saiseikai Yokohamashi Tobu Hospital, 3-6-1 Shimosueyoshi, Tsurumi-ku, Yokohama-shi, Kanagawa 230-0012, Japan.
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Orita
authors.affiliation: Department of Trauma and Emergency Surgery, Saiseikai Yokohamashi Tobu Hospital, 3-6-1 Shimosueyoshi, Tsurumi-ku, Yokohama-shi, Kanagawa 230-0012, Japan.
authors.forename: Kei
authors.initials: K
authors.lastname: Hayashida
authors.affiliation: Department of Trauma and Emergency Surgery, Saiseikai Yokohamashi Tobu Hospital, 3-6-1 Shimosueyoshi, Tsurumi-ku, Yokohama-shi, Kanagawa 230-0012, Japan.
authors.forename: Mitsuhide
authors.initials: M
authors.lastname: Kitano
mesh_terms: D000328:Adult; D000368:Aged; D019540:Area Under Curve; D015415:Biomarkers / Q000378:metabolism; D015331:Cohort Studies; D004636:Emergency Service, Hospital; D050556:Fatty Acid-Binding Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D007410:Intestinal Diseases / Q000401:mortality / Q000473:pathology / Q000601:surgery; D007420:Intestine, Large / Q000098:blood supply* / Q000473:pathology; D007421:Intestine, Small / Q000098:blood supply* / Q000473:pathology; D007511:Ischemia / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D011379:Prognosis; D012042:Registries; D012189:Retrospective Studies; D018570:Risk Assessment; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; C493404:FABP2 protein, human; D050556:Fatty Acid-Binding Proteins
keywords: Biomarkers; Diagnosis; Intestinal fatty acid-binding protein; Ischemia; Pneumatosis intestinalis