title: Periprocedural antithrombotic therapy during various types of percutaneous cardiovascular interventions.
abstract: Percutaneous catheter-based interventions became a critically important part of treatment in modern cardiology, improving quality of life as well as saving many life. Due to the introduction of foreign materials to the circulation (either temporarily or permanently) and due to a certain damage to the endothelium or endocardium, the risk of thrombotic complications is substantial and thus some degree of antithrombotic therapy is needed during all these procedures. The intensity (dosage, combination, and duration) of periprocedureal antithrombotic treatment largely varies based on the type of procedure, clinical setting, and comorbidities. This manuscript summarizes the current therapeutic approach to prevent clotting (and bleeding) during a large spectrum of interventions: acute and elective coronary interventions, acute stroke interventions and elective carotid stenting, electrophysiology procedures, interventions for structural heart disease, and peripheral arterial interventions.
authors.affiliation: Cardiocenter, University Hospital Kralovske Vinohrady, Third Faculty of Medicine, Charles University Prague, Srobarova 50, 100 34 Prague 10, Czech Republic petr.widimsky@fnkv.cz.
authors.forename: P
authors.initials: P
authors.lastname: Widimský
authors.affiliation: Cardiocenter, University Hospital Kralovske Vinohrady, Third Faculty of Medicine, Charles University Prague, Srobarova 50, 100 34 Prague 10, Czech Republic.
authors.forename: V
authors.initials: V
authors.lastname: Kočka
authors.affiliation: Cardiocenter, University Hospital Kralovske Vinohrady, Third Faculty of Medicine, Charles University Prague, Srobarova 50, 100 34 Prague 10, Czech Republic.
authors.forename: F
authors.initials: F
authors.lastname: Roháč
authors.affiliation: Cardiocenter, University Hospital Kralovske Vinohrady, Third Faculty of Medicine, Charles University Prague, Srobarova 50, 100 34 Prague 10, Czech Republic.
authors.forename: P
authors.initials: P
authors.lastname: Osmančík
mesh_terms: D003328:Coronary Thrombosis / Q000209:etiology / Q000517:prevention & control*; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D009203:Myocardial Infarction / Q000517:prevention & control; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000379:methods*; D011183:Postoperative Complications / Q000517:prevention & control*
chemical_list: D005343:Fibrinolytic Agents
keywords: Ablation; Anticoagulants; Antiplatelet drugs; Antithrombotic therapy; Device implantation; Percutaneous interventions; Stents; Thrombolytics