title: Core-oscillator model of Caulobacter crescentus.
abstract: The gram-negative bacterium Caulobacter crescentus is a powerful model organism for studies of bacterial cell cycle regulation. Although the major regulators and their connections in Caulobacter have been identified, it still is a challenge to properly understand the dynamics of its circuitry which accounts for both cell cycle progression and arrest. We show that the key decision module in Caulobacter is built from a limit cycle oscillator which controls the DNA replication program. The effect of an induced cell cycle arrest is demonstrated to be a key feature to classify the underlying dynamics.
authors.affiliation: Université de Lille 1, CNRS, UGSF UMR 8576, 59000 Lille, France.
authors.forename: Yves
authors.initials: Y
authors.lastname: Vandecan
authors.affiliation: Aix-Marseille Université, CNRS, LCB UMR 7283, 13009 Marseille, France.
authors.forename: Emanuele
authors.initials: E
authors.lastname: Biondi
authors.affiliation: Université de Lille 1, CNRS, UGSF UMR 8576, 59000 Lille, France.
authors.forename: Ralf
authors.initials: R
authors.lastname: Blossey
mesh_terms: D016935:Caulobacter crescentus / Q000235:genetics / Q000502:physiology*; D002453:Cell Cycle / Q000235:genetics; D002455:Cell Division; D004261:DNA Replication; D008954:Models, Biological