title: Long-term outcomes of 47 patients with aggressive fibromatosis of the chest treated with surgery.
abstract: OBJECTIVE
  The purpose of the study was to review a large series of chest aggressive fibromatosis (AF) cases with an emphasis on the outcomes of different degrees of resection and the value of postoperative radiotherapy.
  
  
  METHODS
  The records of patients with chest AF treated at our hospital from 1982 to 2014 were retrospectively reviewed. Recurrence rates and non-disease survival (NDS) times were compared between the R0, R1, and R2 resection groups.
  
  
  RESULTS
  Forty-seven cases of chest AF were treated during the study period (21 men, 26 women), with an average age at diagnosis of 40 years (range, 9-77 years). One patient died before surgery, and 46 patients received a total of 85 resections. Forty-one patients had complete follow-up data, and the average follow-up time was 125.6 months (range, 11-524 months). Recurrence rates were 6.7%, 92.9%, and 100% for the R0, R1, and R2 resection groups, respectively, and the R0 recurrence rate was significantly lower than the R1 and R2 rates (both P values < 0.001). The NDS time of the R0, R1, and R2 groups was 80.3 ± 64.8, 23.6 ± 38.7, and 9.8 ± 10.8 months, respectively; the NDS time of the R0 group was significantly longer than that of the R1 and R2 groups (both P values < 0.01). Within each resection type, no significant differences were found in the recurrence rates of patients having surgery alone compared with those receiving surgery and radiotherapy (all P values > 0.05).
  
  
  CONCLUSIONS
  R0 resection is the most effective treatment for chest AF. Postoperative radiotherapy did not reduce the recurrence rate.
authors.affiliation: Department of Thoracic Surgery, Peking Union Medical College Hospital, CAMS & PUMC, Beijing, 100730, China.
authors.forename: D
authors.initials: D
authors.lastname: Ma
authors.affiliation: Department of Thoracic Surgery, Peking Union Medical College Hospital, CAMS & PUMC, Beijing, 100730, China. Electronic address: lsq6768@sohu.com.
authors.forename: S
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Thoracic Surgery, Peking Union Medical College Hospital, CAMS & PUMC, Beijing, 100730, China.
authors.forename: R
authors.initials: R
authors.lastname: Fu
authors.affiliation: Department of Thoracic Surgery, Peking Union Medical College Hospital, CAMS & PUMC, Beijing, 100730, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Thoracic Surgery, Peking Union Medical College Hospital, CAMS & PUMC, Beijing, 100730, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Cui
authors.affiliation: Department of Thoracic Surgery, Peking Union Medical College Hospital, CAMS & PUMC, Beijing, 100730, China.
authors.forename: H
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Pathology, Peking Union Medical College Hospital, CAMS & PUMC, Beijing, 100730, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Meng
authors.affiliation: Department of Pathology, Peking Union Medical College Hospital, CAMS & PUMC, Beijing, 100730, China.
authors.forename: W
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Pathology, Peking Union Medical College Hospital, CAMS & PUMC, Beijing, 100730, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Bi
authors.affiliation: Department of Pathology, Peking Union Medical College Hospital, CAMS & PUMC, Beijing, 100730, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Xiao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D018222:Desmoid Tumors / Q000401:mortality / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D013899:Thoracic Neoplasms / Q000401:mortality / Q000601:surgery*
keywords: Aggressive fibromatosis; Chest wall defect; Desmoid; Reconstruction