title: A comprehensive review of microRNA-related polymorphisms in gastric cancer.
abstract: MicroRNAs (miRNAs) are a class of small non-coding RNA molecules of about 22 nucleotides in length. miRNAs are highly conserved in both plants and animals, and function as gene regulators by binding to the 3'-untranslated region of target mRNAs for cleavage and/or translational repression. miRNA biogenesis, stability, and regulation of expression are strongly sequence dependent. Sequence variants, such as single nucleotide polymorphisms (SNPs) in pri-miRNA, pre-miRNA, promoter regions, or miRNA-target sites, can influence miRNA function, thereby contributing to the pathological features of human disease. In this review, we focus on miRNA-related SNPs in gastric cancer and comprehensively analyze some commonly studied SNPs.
authors.affiliation: Secondary Department of General Surgery, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, Henan, China.
authors.forename: B W
authors.initials: BW
authors.lastname: Han
authors.affiliation: Secondary Department of General Surgery, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, Henan, China.
authors.forename: Z H
authors.initials: ZH
authors.lastname: Li
authors.affiliation: Secondary Department of General Surgery, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, Henan, China.
authors.forename: S F
authors.initials: SF
authors.lastname: Liu
authors.affiliation: Secondary Department of General Surgery, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, Henan, China.
authors.forename: H B
authors.initials: HB
authors.lastname: Han
authors.affiliation: Secondary Department of General Surgery, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, Henan, China.
authors.forename: S J
authors.initials: SJ
authors.lastname: Dong
authors.affiliation: Central Laboratory, Yunnan University of Chinese Traditional Medicine, Kunming, Yunnan, China.
authors.forename: H J
authors.initials: HJ
authors.lastname: Zou
authors.affiliation: Central Laboratory, Yunnan University of Chinese Traditional Medicine, Kunming, Yunnan, China.
authors.forename: R F
authors.initials: RF
authors.lastname: Sun
authors.affiliation: Center for Molecular Medicine, Zhejiang Academy of Medical Sciences, Hangzhou, Zhejiang, China.
authors.forename: J
authors.initials: J
authors.lastname: Jia
mesh_terms: D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012333:RNA, Messenger / Q000235:genetics; D013274:Stomach Neoplasms / Q000235:genetics*
chemical_list: D035683:MicroRNAs; D012333:RNA, Messenger