title: Chemical study of the fungus Psilocybe merdaria.
abstract: Chemical investigation on the cultures of the fungus Psilocybe merdaria resulted in the first isolation of 10 compounds including two new ones 11,14-dihydroxylneoechinulin E (1) and (S)-4-(4-methylpent-3-en-1-yl)-butyrolactone (2). Their structures were elucidated from the analysis of 1D and 2D NMR and MS data. Among them, compound 7 showed inhibitory activity against AChE with 20% percentage at a concentration of 50 μg/ml.
authors.affiliation: a College of Food Science and Technology , Nanjing Agricultural University , Nanjing 210095 , China.|b Key Laboratory of Biology and Genetic Resources of Tropical Crops , Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences , Haikou 571101 , China.
authors.forename: Ning-Ning
authors.initials: NN
authors.lastname: Yang
authors.affiliation: b Key Laboratory of Biology and Genetic Resources of Tropical Crops , Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences , Haikou 571101 , China.
authors.forename: Qing-Yun
authors.initials: QY
authors.lastname: Ma
authors.affiliation: b Key Laboratory of Biology and Genetic Resources of Tropical Crops , Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences , Haikou 571101 , China.
authors.forename: Sheng-Zhuo
authors.initials: SZ
authors.lastname: Huang
authors.affiliation: b Key Laboratory of Biology and Genetic Resources of Tropical Crops , Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences , Haikou 571101 , China.
authors.forename: Fan-Dong
authors.initials: FD
authors.lastname: Kong
authors.affiliation: b Key Laboratory of Biology and Genetic Resources of Tropical Crops , Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences , Haikou 571101 , China.
authors.forename: Hao-Fu
authors.initials: HF
authors.lastname: Dai
authors.affiliation: a College of Food Science and Technology , Nanjing Agricultural University , Nanjing 210095 , China.
authors.forename: Zhi-Fang
authors.initials: ZF
authors.lastname: Yu
authors.affiliation: b Key Laboratory of Biology and Genetic Resources of Tropical Crops , Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences , Haikou 571101 , China.
authors.forename: You-Xing
authors.initials: YX
authors.lastname: Zhao
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000110:Acetylcholinesterase / Q000187:drug effects; D002681:China; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005658:Fungi / Q000378:metabolism; D026121:Indole Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D055391:Psilocybe / Q000737:chemistry*
chemical_list: C000616941:(S)-4-(4-methylpent-3-en-1-yl)-butyrolactone; C000616940:11,14-dihydroxylneoechinulin E; D002800:Cholinesterase Inhibitors; D026121:Indole Alkaloids; D000110:Acetylcholinesterase; D015107:4-Butyrolactone
keywords: AChE inhibitory activity; Psilocybe; Psilocybe merdaria; indole alkaloids