title: A cross-sectional study to investigate the correlation between depression comorbid with anxiety and serum lipid levels.
abstract: Depression is a common psychological disorder that severely threatens human health. Its pathology remains unclear, but it has been suggested to be associated with abnormal blood lipid metabolism.
  
  
  
  This study aimed to explore the changes in blood lipid levels in patients with depression accompanied or not by anxiety, and assess whether adjusting the clinical therapeutic strategy could be based on blood lipid test results, providing a novel insight into depression treatment.
  
  
  
  This was a cross-sectional study. We assessed 60 outpatients and inpatients diagnosed with depression from January 2013 to January 2014 who met the Chinese Classification of Mental Disorders version 3 (CCMD-3) criteria, with Hamilton Rating Scale for Depression (HAMD-24) ≥20. They were grouped into depression with anxiety (n=29) and depression without anxiety (n=31) groups by the Hamilton Anxiety Scale (HAMA).
  
  
  
  TG levels were higher in the depression with anxiety group compared with patients without anxiety (P=0.045), which was confirmed by multifactorial analysis [P=0.017, OR=4.394, 95% CI (1.303-14.824)]. A negative correlation between anxiety score and HDL levels was observed in patients with depression (r=-0.340, P=0.046). Meanwhile, positive associations were obtained between retardation and LDL levels (r=0.307, P=0.017) as well as age at disease onset and total cholesterol levels (r=0.410, P=0.002).
  
  
  
  TG levels differ in patients with depression accompanied by anxiety compared with those without anxiety.
authors.affiliation: Department of Neurology, The Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou,Fujian, China. Electronic address: 2748786162@qq.com.
authors.forename: Jinmin
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Neurology, Chinese Medicine Hospital of Fuzhou Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou,Fujian, China.
authors.forename: Changying
authors.initials: C
authors.lastname: Jiang
authors.affiliation: Fuzhou Neuro-psychiatric Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou,Fujian, China.
authors.forename: Liling
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Neurology, The Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou,Fujian, China.
authors.forename: Songying
authors.initials: S
authors.lastname: Wu
authors.affiliation: Department of Neurology, The Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou,Fujian, China.
authors.forename: Jushan
authors.initials: J
authors.lastname: Lin
authors.affiliation: Department of Neurology, The Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou,Fujian, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Gao
authors.affiliation: Department of Neurology, The Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou,Fujian, China.
authors.forename: Buni
authors.initials: B
authors.lastname: Xie
authors.affiliation: Clinical Laboratory, The Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine,Fuzhou,Fujian, China.
authors.forename: Dengzi
authors.initials: D
authors.lastname: Zheng
authors.affiliation: Department of Neurology, The Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou,Fujian, China.
authors.forename: Ruiling
authors.initials: R
authors.lastname: Yang
authors.affiliation: Department of Neurology, The Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou,Fujian, China.
authors.forename: Shiju
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Neurology, The Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou,Fujian, China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Pan
authors.affiliation: Department of Neurology, The Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou,Fujian, China.
authors.forename: Yuansheng
authors.initials: Y
authors.lastname: Liao
mesh_terms: D000328:Adult; D001008:Anxiety Disorders / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D002681:China; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003866:Depressive Disorder / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D013223:Statistics as Topic
chemical_list: D008055:Lipids