title: Seasonality and BDNF polymorphism influences depression outcome in patients with atopic dermatitis and psoriasis.
abstract: To examine the effect of seasonality and rs6265 genotype on depression outcome and brain-derived neurotrophic factor (BDNF) level with dermatitis patients from onset through remission.
  
  
  
  Atopic dermatitis (AD, 56) and psoriasis (PS, 33) patients and healthy controls (HC, 49) were recruited over the 2014 calendar year. Patients were subdivided by immunoglobulin E (IgE) sensitivity (AD only), season and rs6265 genotype. Assessments were performed at onset and week 10 (Hamilton Depression Rating Scale [HAM-D], SCORAD/PASI, IgE, BDNF). Patients received standard corticosteroid and antihistamine interventions.
  
  
  
  All patients responded to corticosteroid treatment. Seasonally differential outcomes were observed in all groups. HAM-D was elevated at onset and improved over 10 weeks: AD cohort 1 (autumn/winter, AD-1) patients improved and AD cohort 2 (spring/summer, AD-2) patients remained elevated. BDNF levels were elevated in AD and seasonal differential: AD-2 declined at 10 weeks, whereas AD-1 remained high (intrinsic AD) or elevated further (extrinsic AD). PS cohort 2 declined to below control at 10 weeks. AD Val/Val had persistently elevated HAM-D and AD Val/Met were either normal (AD-1) or persistently elevated (AD-2).
  
  
  
  Findings presented here suggest a strong influence of seasonality on depression outcome and BDNF expression in AD and PS and likely reflect separate patient populations which differentially respond to environment-based stressors.
authors.affiliation: a Department of Dermatovenereology , Astana Medical University , Astana , Kazakhstan.
authors.forename: Tatyana
authors.initials: T
authors.lastname: Vinnik
authors.affiliation: b Department of Molecular Biology , Ariel University , Ariel , Israel.
authors.forename: Michael
authors.initials: M
authors.lastname: Kirby
authors.affiliation: b Department of Molecular Biology , Ariel University , Ariel , Israel.
authors.forename: Maryia
authors.initials: M
authors.lastname: Bairachnaya
authors.affiliation: b Department of Molecular Biology , Ariel University , Ariel , Israel.
authors.forename: Igor
authors.initials: I
authors.lastname: Koman
authors.affiliation: a Department of Dermatovenereology , Astana Medical University , Astana , Kazakhstan.
authors.forename: Tatyana
authors.initials: T
authors.lastname: Tarkina
authors.affiliation: a Department of Dermatovenereology , Astana Medical University , Astana , Kazakhstan.
authors.forename: Gulnaz
authors.initials: G
authors.lastname: Sadykova
authors.affiliation: c National Research Centre of Maternal and Child Health , Astana , Kazakhstan.
authors.forename: Gulshara
authors.initials: G
authors.lastname: Abildinova
authors.affiliation: a Department of Dermatovenereology , Astana Medical University , Astana , Kazakhstan.
authors.forename: Gulnara
authors.initials: G
authors.lastname: Batpenova
authors.affiliation: b Department of Molecular Biology , Ariel University , Ariel , Israel.
authors.forename: Albert
authors.initials: A
authors.lastname: Pinhasov
mesh_terms: D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D000328:Adult; D000368:Aged; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood* / Q000235:genetics*; D003863:Depression / Q000503:physiopathology*; D003876:Dermatitis, Atopic / Q000097:blood / Q000188:drug therapy / Q000276:immunology / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011565:Psoriasis / Q000097:blood / Q000188:drug therapy / Q000276:immunology / Q000523:psychology; D012621:Seasons
chemical_list: D000305:Adrenal Cortex Hormones; D019208:Brain-Derived Neurotrophic Factor; D007073:Immunoglobulin E; C579455:BDNF protein, human
keywords: Atopic dermatitis; brain-derived neurotrophic factor; depression; psoriasis; seasonal variation