title: Effectiveness of Four Disinfectants against Ebola Virus on Different Materials.
abstract: The West Africa Ebola virus (EBOV) outbreak has highlighted the need for effective disinfectants capable of reducing viral load in a range of sample types, equipment and settings. Although chlorine-based products are widely used, they can also be damaging to equipment or apparatus that needs continuous use such as aircraft use for transportation of infected people. Two aircraft cleaning solutions were assessed alongside two common laboratory disinfectants in a contact kill assay with EBOV on two aircraft relevant materials representative of a porous and non-porous surface. A decimal log reduction of viral titre of 4 is required for a disinfectant to be deemed effective and two of the disinfectants fulfilled this criteria under the conditions tested. One product, Ardrox 6092, was found to perform similarly to sodium hypochlorite, but as it does not have the corrosive properties of sodium hypochlorite, it could be an alternative disinfectant solution to be used for decontamination of EBOV on sensitive apparatus.
authors.affiliation: CBR Division, Defence Science and Technology Laboratory (Dstl), Room 201, Building 7a. Dstl, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK. sjsmither@dstl.gov.uk.
authors.forename: Sophie
authors.initials: S
authors.lastname: Smither
authors.affiliation: CBR Division, Defence Science and Technology Laboratory (Dstl), Room 201, Building 7a. Dstl, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK. alphelps@dstl.gov.uk.
authors.forename: Amanda
authors.initials: A
authors.lastname: Phelps
authors.affiliation: CBR Division, Defence Science and Technology Laboratory (Dstl), Room 201, Building 7a. Dstl, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK. lseastaugh@dstl.gov.uk.
authors.forename: Lin
authors.initials: L
authors.lastname: Eastaugh
authors.affiliation: CBR Division, Defence Science and Technology Laboratory (Dstl), Room 201, Building 7a. Dstl, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK. sangugi@dstl.gov.uk.
authors.forename: Sarah
authors.initials: S
authors.lastname: Ngugi
authors.affiliation: CBR Division, Defence Science and Technology Laboratory (Dstl), Room 201, Building 7a. Dstl, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK. lmobrien@dstl.gov.uk.
authors.forename: Lyn
authors.initials: L
authors.lastname: O'Brien
authors.affiliation: MIG-CCHS2/C2, 1710 Naval Air Squadron, Room 104c, Unicorn House, Yeovilton BA22 8HW, UK. NAVY1710NAS-MIGCCHS2@mod.uk.
authors.forename: Andrew
authors.initials: A
authors.lastname: Dutch
authors.affiliation: CBR Division, Defence Science and Technology Laboratory (Dstl), Room 201, Building 7a. Dstl, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK. mslever@dstl.gov.uk.
authors.forename: Mark Stephen
authors.initials: MS
authors.lastname: Lever
mesh_terms: D004202:Disinfectants / Q000494:pharmacology*; D029043:Ebolavirus / Q000187:drug effects* / Q000502:physiology*; D050296:Microbial Viability / Q000187:drug effects; D019562:Viral Load; D038301:Virus Inactivation
chemical_list: D004202:Disinfectants
keywords: Ebola virus; decontamination; disinfection; inactivation; safety; sodium hypochlorite