title: Modelling Lagged Associations in Environmental Time Series Data: A Simulation Study.
abstract: This study assesses two alternative approaches for investigating linear and nonlinear lagged associations in environmental time series data, comparing through simulations simple methods based on moving average summaries with more flexible distributed lag linear and nonlinear models. Results indicate that the latter provide estimates with no or low bias and close-to-nominal confidence intervals, even for long-lagged associations and in the presence of strong seasonal trends. Moving average models represent a viable alternative only in the presence of relatively short lag periods, and when the lag interval is correctly specified. In contrast, the use of moving averages to roughly approximate long and complex lag patterns, or the specification of an interval different than the actual lag period, can result in substantial biases. More flexible approaches based on distributed lag linear or nonlinear models provide noteworthy advantages, in particular when complex lagged associations are assumed.
authors.affiliation: From the Department of Social and Environmental Health Research, London School of Hygiene and Tropical Medicine, London, United Kingdom.
authors.forename: Antonio
authors.initials: A
authors.lastname: Gasparrini
mesh_terms: D000397:Air Pollution / Q000706:statistics & numerical data*; D002641:Chicago; D003198:Computer Simulation; D004781:Environmental Exposure / Q000706:statistics & numerical data*; D004812:Epidemiologic Methods; D006801:Humans; D016014:Linear Models; D009026:Mortality; D017711:Nonlinear Dynamics; D013696:Temperature; D013997:Time Factors