title: EXPERIMENTAL SUBCUTANEOUS CYSTICERCOSIS BY Taenia crassiceps IN BALB/c AND C57BL/6 MICE.
abstract: Human cysticercosis is one of the most severe parasitic infections affecting tissues. Experimental models are needed to understand the host-parasite dynamics involved throughout the course of the infection. The subcutaneous experimental model is the closest to what is observed in human cysticercosis that does not affect the central nervous system. The aim of this study was to evaluate macroscopically and microscopically the experimental subcutaneous cysticercosis caused by Taenia crassiceps cysticerci in BALB/c and C57BL/6 mice. Animals were inoculated in the dorsal subcutaneous region and macroscopic and microscopic aspects of the inflammatory process in the host-parasite interface were evaluated until 90 days after the inoculation (DAI). All the infected animals presented vesicles containing cysticerci in the inoculation site, which was translucent at 7 DAI and then remained opaque throughout the experimental days. The microscopic analysis showed granulation tissue in BALB/c mice since the acute phase of infection evolving to chronicity without cure, presenting 80% of larval stage cysticerci at 90 DAI. While C57BL/6 mice presented 67% of final stage cysticerci at 90 DAI, the parasites were surrounded by neutrophils evolving to the infection control. It is possible to conclude that the genetic features of susceptibility (BALB/c) or resistance (C57BL/6) were confirmed in an experimental subcutaneous model of cysticercosis.
authors.affiliation: Tropical Pathology and Public Health Institute (UFG), rua 235 s/n, Setor Universitario 74650-050 Goiânia, GO, Brasil. E-mails: lila-pf@hotmail.com; sarahbuzaim@hotmail.com; alinefreitas2@gmail.com; marinavinaud@gmail.com; ruylino@yahoo.com.br.
authors.forename: Íria Márcia
authors.initials: ÍM
authors.lastname: Pereira
authors.affiliation: Tropical Pathology and Public Health Institute (UFG), rua 235 s/n, Setor Universitario 74650-050 Goiânia, GO, Brasil. E-mails: lila-pf@hotmail.com; sarahbuzaim@hotmail.com; alinefreitas2@gmail.com; marinavinaud@gmail.com; ruylino@yahoo.com.br.
authors.forename: Sarah Buzaim
authors.initials: SB
authors.lastname: Lima
authors.affiliation: Tropical Pathology and Public Health Institute (UFG), rua 235 s/n, Setor Universitario 74650-050 Goiânia, GO, Brasil. E-mails: lila-pf@hotmail.com; sarahbuzaim@hotmail.com; alinefreitas2@gmail.com; marinavinaud@gmail.com; ruylino@yahoo.com.br.
authors.forename: Aline de Araújo
authors.initials: Ade A
authors.lastname: Freitas
authors.affiliation: Tropical Pathology and Public Health Institute (UFG), rua 235 s/n, Setor Universitario 74650-050 Goiânia, GO, Brasil. E-mails: lila-pf@hotmail.com; sarahbuzaim@hotmail.com; alinefreitas2@gmail.com; marinavinaud@gmail.com; ruylino@yahoo.com.br.
authors.forename: Marina Clare
authors.initials: MC
authors.lastname: Vinaud
authors.affiliation: Tropical Pathology and Public Health Institute (UFG), rua 235 s/n, Setor Universitario 74650-050 Goiânia, GO, Brasil. E-mails: lila-pf@hotmail.com; sarahbuzaim@hotmail.com; alinefreitas2@gmail.com; marinavinaud@gmail.com; ruylino@yahoo.com.br.
authors.forename: Ruy de Souza Lino
authors.initials: Rde S
authors.lastname: Junior
mesh_terms: D000818:Animals; D003551:Cysticercosis / Q000469:parasitology* / Q000473:pathology*; D004195:Disease Models, Animal; D006790:Host-Parasite Interactions; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D013621:Taenia / Q000254:growth & development / Q000502:physiology*; D013997:Time Factors