title: A patient with schizophrenia presenting with post-lobotomy catatonia treated with olanzapine: a case report.
abstract: A 79-year-old Japanese woman with schizophrenia was hospitalized because of idiopathic duodenal stenosis. Three days after discontinuing ingestion, including the administration of psychotropic drugs, the patient demonstrated incoherent behaviour and strong general muscle tension, and was unable to engage in conversation. Computed tomography indicated bilateral regions of low density in the frontal lobes, subsequent to which she was diagnosed with post-lobotomy catatonia. Administration of olanzapine (10 mg/day) improved the patient's condition within a short period. Previous studies have demonstrated an association between the dysfunction of frontal circuits and catatonia; therefore, the observed catatonic episode might relate to the disconnection of nerve fibres in the prefrontal lobes induced by her lobotomy. Olanzapine was likely effective in treating catatonia because of its reported efficacy in improving frontal lobe function.
authors.affiliation: Department of Psychiatry, Juntendo Tokyo Koto Geriatric Medical Center, Tokyo, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Kumagai
authors.affiliation: Department of Psychiatry, Youwa Hospital, Tokyo, Japan.
authors.forename: Maiko
authors.initials: M
authors.lastname: Kitazawa
authors.affiliation: Department of Surgery, Juntendo Tokyo Koto Geriatric Medical Center, Tokyo, Japan.
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Ishibiki
authors.affiliation: Department of Surgery, Juntendo Tokyo Koto Geriatric Medical Center, Tokyo, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Narumi
authors.affiliation: Department of Psychiatry, Juntendo Tokyo Koto Geriatric Medical Center, Tokyo, Japan.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Ichimiya
mesh_terms: D000368:Aged; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000627:therapeutic use*; D002389:Catatonia / Q000601:surgery; D005260:Female; D006801:Humans; D000077152:Olanzapine; D011183:Postoperative Complications; D011612:Psychosurgery / Q000009:adverse effects*; D012559:Schizophrenia / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D000077152:Olanzapine
keywords: catatonia; lobotomy; olanzapine; schizophrenia