title: Frequency-Dependent Neural Activity in Patients with Unilateral Vascular Pulsatile Tinnitus.
abstract: Previous resting-state functional magnetic resonance imaging (rs-fMRI) studies have shown that neurological changes are important findings in vascular pulsatile tinnitus (PT) patients. Here, we utilized rs-fMRI to measure the amplitude of low-frequency fluctuations (ALFF) in forty patients with unilateral PT and forty age-, gender-, and education-matched normal control subjects. Two different frequency bands (slow-4, 0.027-0.073 Hz, and slow-5, 0.010-0.027 Hz, which are more sensitive to subcortical and cortical neurological signal changes, resp.) were analyzed to examine the intrinsic brain activity in detail. Compared to controls, PT patients had increased ALFF values mainly in the PCu, bilateral IPL (inferior parietal lobule), left IFG (inferior frontal gyrus), and right IFG/anterior insula and decreased ALFF values in the multiple occipital areas including bilateral middle-inferior occipital lobe. For the differences of the two frequency bands, widespread ALFF differences were observed. The ALFF abnormalities in aMPFC/ACC, PCu, right IPL, and some regions of occipital and parietal cortices were greater in the slow-5 band compared to the slow-4 band. Additionally, the THI score of PT patients was positively correlated with changes in slow-5 and slow-4 band in PCu. Pulsatile tinnitus is a disease affecting the neurological activities of multiple brain regions. Slow-5 band is more sensitive in detecting the alternations. Our results also indicated the importance of pathophysiological investigations in patients with pulsatile tinnitus in the future.
authors.affiliation: Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China; Neuroradiology Division, Department of Radiology, Stanford University, Stanford, CA 94305, USA.
authors.forename: Han
authors.initials: H
authors.lastname: Lv
authors.affiliation: Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Zhao
authors.affiliation: Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
authors.forename: Guopeng
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Zeng
authors.affiliation: Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Yan
authors.affiliation: Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Dong
authors.affiliation: Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Li
authors.affiliation: Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.affiliation: Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Li
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
authors.forename: Shusheng
authors.identifier: 0000-0001-6847-3195
authors.initials: S
authors.lastname: Gong
authors.affiliation: Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
authors.forename: Zhenchang
authors.identifier: 0000-0002-9551-2660
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000000981:diagnostic imaging* / Q000503:physiopathology; D014012:Tinnitus / Q000000981:diagnostic imaging* / Q000503:physiopathology; D055815:Young Adult