title: Shear Wave Elastography Quantifies Stiffness in Ex Vivo Porcine Artery with Stiffened Arterial Region.
abstract: Five small porcine aortas were used as a human carotid artery model, and their stiffness was estimated using shear wave elastography (SWE) in the arterial wall and a stiffened artery region mimicking a stiff plaque. To optimize the SWE settings, shear wave bandwidth was measured with respect to acoustic radiation force push length and number of compounded angles used for motion detection with plane wave imaging. The mean arterial wall and simulated plaque shear moduli varied from 41 ± 5 to 97 ± 10 kPa and from 86 ± 13 to 174 ± 35 kPa, respectively, over the pressure range 20-120 mmHg. The results revealed that a minimum bandwidth of approximately 1500 Hz is necessary for consistent shear modulus estimates, and a high pulse repetition frequency using no image compounding is more important than a lower pulse repetition frequency with better image quality when estimating arterial wall and plaque stiffness using SWE.
authors.affiliation: Department of Medical Engineering, School of Technology and Health, KTH Royal Institute of Technology, Stockholm, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, Solna, Sweden. Electronic address: erik.widman@sth.kth.se.
authors.forename: Erik
authors.initials: E
authors.lastname: Widman
authors.affiliation: Department of Medical Engineering, School of Technology and Health, KTH Royal Institute of Technology, Stockholm, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, Solna, Sweden.
authors.forename: Elira
authors.initials: E
authors.lastname: Maksuti
authors.affiliation: Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
authors.forename: Carolina
authors.initials: C
authors.lastname: Amador
authors.affiliation: Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota, USA; Department of Radiology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Urban
authors.affiliation: Department of Molecular Medicine and Surgery, Karolinska Institutet, Solna, Sweden.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Caidahl
authors.affiliation: Department of Medical Engineering, School of Technology and Health, KTH Royal Institute of Technology, Stockholm, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, Solna, Sweden.
authors.forename: Matilda
authors.initials: M
authors.lastname: Larsson
mesh_terms: D000818:Animals; D001011:Aorta / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D055119:Elastic Modulus / Q000502:physiology; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D008297:Male; D023421:Models, Animal; D033081:Shear Strength / Q000502:physiology; D013314:Stress, Mechanical; D013552:Swine
keywords: Arteriosclerosis; Artery; Atherosclerosis; Elasticity; Ex vivo; Phase velocity; Plaque; Shear wave elastography; Ultrasound