title: Prolonged Stimulation of Corticosterone Secretion by Corticotropin-Releasing Hormone in Rats Exhibiting High Preference for Dietary Fat.
abstract: Through the secretion of corticosterone, the hypothalamo-pituitary-adrenal (HPA) axis is thought to play an important role in the regulation of caloric intake and dietary fat preference. In an earlier study, we demonstrated a positive correlation between urinary corticosterone output and dietary fat preference. Furthermore, dietary fat preference was augmented following chronic but not acute hypercorticosteronemia produced by exogenous corticosterone administration. These observations led us to explore whether the HPA axis of rats exhibiting high preference for fat may have exaggerated sensitivity to corticotropinreleasing hormone (CRH). The results of these studies show a delayed and blunted but more prolonged corticosterone response to CRH in the fat-preferring rats compared with that of the carbohydrate-preferring rats.
authors.affiliation: a Obesity Research Program, Section of Endocrinology, Department of Medicine , Louisiana State University Medical Center , 1542 Tulane Ave., New Orleans , LA 70112 , USA.
authors.forename: D
authors.initials: D
authors.lastname: Herminghuysen
authors.affiliation: a Obesity Research Program, Section of Endocrinology, Department of Medicine , Louisiana State University Medical Center , 1542 Tulane Ave., New Orleans , LA 70112 , USA.
authors.forename: K
authors.initials: K
authors.lastname: Plaisance
authors.affiliation: b USGS/BRD , Louisiana Cooperative Fish and Wildlife Research Unit , Baton Rouge , LA 70803 , USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Pace
authors.affiliation: a Obesity Research Program, Section of Endocrinology, Department of Medicine , Louisiana State University Medical Center , 1542 Tulane Ave., New Orleans , LA 70112 , USA.
authors.forename: C
authors.initials: C
authors.lastname: Prasad
keywords: Carbohydrate preference; Corticosterone; Corticotropin-releasing hormone; Fat preference