title: Is intracouple assisted reproductive technology an option for men with large-headed spermatozoa? A literature review and a decision guide proposal.
abstract: Although the presence of spermatozoa with an abnormally large head is rare, it is associated with low fertility or even total infertility. We reviewed the literature on assisted reproductive technology (ART) strategies and outcomes for men with large-headed spermatozoa. We also discuss additional analyses that can usefully characterize sperm defects and help with the choice between intra-couple ART and insemination with donor sperm. Lastly, we propose a classification for cases of large-headed spermatozoa.
authors.affiliation: Laboratoire de Biologie de la Reproduction, Hôpital Tenon, Paris, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Guthauser
authors.affiliation: Centre d'AMP Nataliance, Laboratoire Medibio, Saran, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Pollet-Villard
authors.affiliation: GIG, EA7404, Université Versailles St Quentin en Yvelines, Montigny le Bretonneux, France ; Unité de Biologie de la Reproduction, CHI de Poissy St Germain, Poissy, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Boitrelle
authors.affiliation: GIG, EA7404, Université Versailles St Quentin en Yvelines, Montigny le Bretonneux, France.
authors.forename: Francois
authors.initials: F
authors.lastname: Vialard
keywords: Assisted reproductive technology outcomes; Fluorescence in situ hybridization; Large-headed spermatozoa; Macrocephalic sperm head syndrome; Sperm head measurement