title: Invasive sinonasal adenocarcinoma with an absent olfactory bulb: a case report.
abstract: Sinonasal adenocarcinomas are rare, locally invasive tumours. In this case the symptomatic profile was unusual and the diagnosis was missed at the primary care stage. Interestingly this would be the first documented case with an absent ipsilateral olfactory bulb. A 55-year old male presented with symptoms of behavioural change and mild headaches. He was later found to have a large Sinonasal adenocarcinoma which penetrated the skull base. This was treated by a combined craniotomy and endonasal approach. Sinonasal adenocarcinomas are unusual tumours and further research is required in order to clarify management strategies and prognosis. This interesting case was more unusual again given its presentation, extent and absence of the olfactory bulb. Importantly for primary care physicians the initial diagnosis was considered psychiatric rather than organic; despite there being specific features of the presentation which were suggestive of an intra-cranial lesion.
authors.affiliation: Imperial College School of Medicine, South Kensington Campus, Exhibition Road, London SW7 2AZ, UK, thnewman@doctors.org.uk.
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Newman
authors.affiliation: Waikato District Health Board, Neurosurgery, 222 Pembroke Street, Hamilton NZ 3240, New Zealand.
authors.forename: Geoffrey A
authors.initials: GA
authors.lastname: Tipper
authors.affiliation: Waikato District Health Board, Neurosurgery, 222 Pembroke Street, Hamilton NZ 3240, New Zealand.
authors.forename: Zakier
authors.initials: Z
authors.lastname: Hussain