title: Prenatal exposure to perfluoroalkyl substances and anogenital distance at 3 months of age as marker of endocrine disruption.
abstract: In the Odense child cohort, serum concentrations of perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA) were measured in 649 pregnant women at approximately 12 weeks of gestation. Birth weight, head and abdominal circumferences were measured, and gestational age determined. Anogenital distance (AGD), i.e., the distance from the anus to the genital organs, penile width and body weight were measured 3 months after the expected date of birth in 511 children. PFOS, PFHxS, PFNA and PFDA were associated with a decreased AGD in girls (p-trend<0.05) after adjusting for age and weight-for-age standard deviation score. Specifically, PFOS in the highest quartile was associated with a 2.8mm (95% confidence intervals -4.5;-1.1) reduction in AGD in girls. No such tendencies were seen in boys. However, a tendency toward increased birth weight in girls and reduced in boys suggests that sex-dimorphic effects may occur from endocrine disrupting effects of these substances.
authors.affiliation: Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense, Denmark.
authors.forename: Dorte Vesterholm
authors.initials: DV
authors.lastname: Lind
authors.affiliation: Rigshospitalet, Copenhagen University Hospital, Department of Growth and Reproduction, Blegdamsvej 9, 2100 Copenhagen, Denmark.
authors.forename: Lærke
authors.initials: L
authors.lastname: Priskorn
authors.affiliation: Rigshospitalet, Copenhagen University Hospital, Department of Growth and Reproduction, Blegdamsvej 9, 2100 Copenhagen, Denmark.
authors.forename: Tina Harmer
authors.initials: TH
authors.lastname: Lassen
authors.affiliation: Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense, Denmark.
authors.forename: Flemming
authors.initials: F
authors.lastname: Nielsen
authors.affiliation: Odense University Hospital, Hans Christian Andersen Children's Hospital, Sdr. Boulevard 29, 5000 Odense C, Denmark; Odense Patient data Exploratory Network (OPEN), University of Southern Denmark, Odense, Denmark.
authors.forename: Henriette Boye
authors.initials: HB
authors.lastname: Kyhl
authors.affiliation: Laboratory of Genomic and Molecular Biomedicine, Department of Biology, University of Copenhagen, Universitetsparken 13, DK-2100 Copenhagen, Denmark.
authors.forename: David Møbjerg
authors.initials: DM
authors.lastname: Kristensen
authors.affiliation: Odense University Hospital, Hans Christian Andersen Children's Hospital, Sdr. Boulevard 29, 5000 Odense C, Denmark; Odense University Hospital, Institute for Clinical Research, Sdr. Boulevard 29, 5000 Odense C, Denmark.
authors.forename: Henrik Thybo
authors.initials: HT
authors.lastname: Christesen
authors.affiliation: Odense University Hospital, Department of Obstetrics and Gynaecology, Sdr. Boulevard 29, 5000 Odense C, Denmark; Odense University Hospital, Institute for Clinical Research, Sdr. Boulevard 29, 5000 Odense C, Denmark.
authors.forename: Jan
authors.initials: J
authors.lastname: Steener
authors.affiliation: Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense, Denmark; Department of Environmental Health, Harvard T.H.Chan School of Public Health, Boston, MA 02215, USA.
authors.forename: Philippe
authors.initials: P
authors.lastname: Grandjean
authors.affiliation: Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense, Denmark; Odense University Hospital, Hans Christian Andersen Children's Hospital, Sdr. Boulevard 29, 5000 Odense C, Denmark; Odense Patient data Exploratory Network (OPEN), University of Southern Denmark, Odense, Denmark. Electronic address: dvjensen@health.sdu.dk.
authors.forename: Tina Kold
authors.initials: TK
authors.lastname: Jensen
keywords: anogenital distance; birth weight; endocrine disruption; gestational length; perflourinated compounds; reproduction