title: Blood Group Discrepancy-First Sign of Autoimmune Hemolytic Anemia after Hematopoietic Stem Cell Transplantation in a Child.
abstract: A 12-year-old male child was presented in the emergency with features of anemia and mild icterus on day+67 of HSCT. The child was suffering from Fanconi anemia and undergone HSCT from ABO-matched, fully HLA matched sibling donor. The diagnosis of mixed type AIHA due to cytomegalovirus reactivation was made in the immunohematology laboratory and blood group discrepancy was the first sign of AIHA in this patient. Though the cold agglutinin titer was not significant but the clinical symptoms and laboratory evidences were suggestive of significant hemolysis due to underlying IgG autoantibody. In addition the high complement avidity of IgM autoantibody might also be a contributing factor for clinically significant hemolysis in this case. The patient was successfully treated with phenotype matched blood transfusion, rituximab and oral steroid therapy.
authors.affiliation: Department of Transfusion Medicine, The Mission Hospital, Sector-2C, Immon Kalyan Sarani, Bidhannagar, Durgapur, WB 713212 India.
authors.forename: Suvro Sankha
authors.initials: SS
authors.lastname: Datta
authors.affiliation: Department of Transfusion Medicine, Tata Medical Center, Kolkata, India.
authors.forename: Mahua
authors.initials: M
authors.lastname: Reddy
authors.affiliation: Department of Transfusion Medicine, Tata Medical Center, Kolkata, India.
authors.forename: Sabita
authors.initials: S
authors.lastname: Basu
authors.affiliation: Department of Pediatric Oncology, Tata Medical Center, Kolkata, India.
authors.forename: Shekhar
authors.initials: S
authors.lastname: Krishnan
keywords: Autoantibody; Hematopoietic stem cell transplantation; Phenotype matching