title: Palladium-Catalyzed, Enantioselective Heine Reaction.
abstract: Aziridines are important synthetic intermediates for the generation of nitrogen-containing molecules.N-Acylaziridines undergo rearrangement by ring expansion to produce oxazolines, a process known as the Heine reaction. The first catalytic, enantioselective Heine reaction is reported formeso-N-acylaziridines where a palladium(II)-diphosphine complex is employed. The highly enantioenriched oxazoline products are valuable organic synthons and potential ligands for transition-metal catalysis.
authors.affiliation: Department of Chemistry and Biochemistry, University of North Carolina Wilmington , Dobo Hall, Wilmington, North Carolina 28403, United States.
authors.forename: Molly
authors.initials: M
authors.lastname: Punk
authors.affiliation: Department of Chemistry and Biochemistry, University of North Carolina Wilmington , Dobo Hall, Wilmington, North Carolina 28403, United States.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Merkley
authors.affiliation: Department of Chemistry and Biochemistry, University of North Carolina Wilmington , Dobo Hall, Wilmington, North Carolina 28403, United States.
authors.forename: Katlyn
authors.initials: K
authors.lastname: Kennedy
authors.affiliation: Department of Chemistry and Biochemistry, University of North Carolina Wilmington , Dobo Hall, Wilmington, North Carolina 28403, United States.
authors.forename: Jeremy B
authors.initials: JB
authors.lastname: Morgan
keywords: aziridine; desymmetrization; enantioselective; heterocycles; palladium