title: Regenerative Endodontic Therapy in a Single Visit Using Platelet-rich Plasma and Biodentine in Necrotic and Asymptomatic Immature Molar Teeth: A Report of 3 Cases.
abstract: This report describes 3 successful single-visit regenerative endodontic therapy cases using platelet-rich plasma (PRP) and Biodentine (Septodont, Saint Maurdes Fossés, France) for 3 immature mandibular molar teeth, all with necrotic pulp, in 2 children aged 8 years and 1 aged 9 years. Three teeth were separately diagnosed as having a necrotic pulp. After preparation of the access cavity under rubber dam isolation, the necrotic pulp was removed, and each canal was irrigated with 2.5% sodium hypochlorite, sterile saline, and 17% EDTA solutions. Freshly prepared PRP was injected into each canal up to the cementoenamel junction, and Biodentine was placed directly over the PRP clot. Each access cavity was then restored with composite resin. Follow-up clinical examinations revealed negative responses to cold and electric pulp tests. None of the treated teeth were sensitive to percussion or palpation. Radiographic examination showed continued thickening of root canal walls and apical closure of the root apex of each tooth. Single-visit regenerative endodontic therapy can be considered in necrotic and asymptomatic immature permanent teeth. PRP and Biodentine may serve as scaffold and barrier materials in regenerative endodontic procedures.
authors.affiliation: Department of Pedodontics, Faculty of Dentistry, Erciyes University, Kayseri, Turkey. Electronic address: topcuoglugs@hotmail.com.
authors.forename: Gamze
authors.initials: G
authors.lastname: Topçuoğlu
authors.affiliation: Department of Endodontics, Faculty of Dentistry, Erciyes University, Kayseri, Turkey.
authors.forename: Hüseyin Sinan
authors.initials: HS
authors.lastname: Topçuoğlu
mesh_terms: D058070:Asymptomatic Diseases / Q000628:therapy; D017610:Calcium Compounds / Q000627:therapeutic use*; D002648:Child; D003790:Dental Pulp Necrosis / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008963:Molar / Q000601:surgery*; D053657:Platelet-Rich Plasma; D057872:Pulp Capping and Pulpectomy Agents / Q000627:therapeutic use*; D011670:Pulpectomy / Q000379:methods; D044968:Regenerative Medicine / Q000379:methods*; D012388:Root Canal Irrigants / Q000627:therapeutic use; D012390:Root Canal Therapy / Q000379:methods*; D017640:Silicates / Q000627:therapeutic use*
chemical_list: D017610:Calcium Compounds; D057872:Pulp Capping and Pulpectomy Agents; D012388:Root Canal Irrigants; D017640:Silicates; C506393:tricalcium silicate
keywords: Biodentine; platelet-rich plasma; regenerative endodontics; single visit