title: MEMS-based handheld scanning probe with pre-shaped input signals for distortion-free images in Gabor-domain optical coherence microscopy.
abstract: High-speed scanning in optical coherence tomography (OCT) often comes with either compromises in image quality, the requirement for post-processing of the acquired images, or both. We report on distortion-free OCT volumetric imaging with a dual-axis micro-electro-mechanical system (MEMS)-based handheld imaging probe. In the context of an imaging probe with optics located between the 2D MEMS and the sample, we report in this paper on how pre-shaped open-loop input signals with tailored non-linear parts were implemented in a custom control board and, unlike the sinusoidal signals typically used for MEMS, achieved real-time distortion-free imaging without post-processing. The MEMS mirror was integrated into a compact, lightweight handheld probe. The MEMS scanner achieved a 12-fold reduction in volume and 17-fold reduction in weight over a previous dual-mirror galvanometer-based scanner. Distortion-free imaging with no post-processing with a Gabor-domain optical coherence microscope (GD-OCM) with 2 μm axial and lateral resolutions over a field of view of 1 × 1 mm2is demonstrated experimentally through volumetric images of a regular microscopic structure, an excised human cornea, and in vivo human skin.
authors.forename: Andrea
authors.initials: A
authors.lastname: Cogliati
authors.forename: Cristina
authors.initials: C
authors.lastname: Canavesi
authors.forename: Adam
authors.initials: A
authors.lastname: Hayes
authors.forename: Patrice
authors.initials: P
authors.lastname: Tankam
authors.forename: Virgil-Florin
authors.initials: VF
authors.lastname: Duma
authors.forename: Anand
authors.initials: A
authors.lastname: Santhanam
authors.forename: Kevin P
authors.initials: KP
authors.lastname: Thompson
authors.forename: Jannick P
authors.initials: JP
authors.lastname: Rolland