title: Cholera in pregnant women: the 2012 epidemic at the reference center at the Donka National Hospital in Conakry.
abstract: Cholera is an epidemic diarrheal disease transmitted through the digestive tract; it can cause obstetric complications in pregnant women. The objective of this study was to describe the epidemiological, clinical, and therapeutic aspects of cholera in pregnant women, as well as its course, during the 2012 epidemic in Conakry. This retrospective, descriptive studied examined the records of this epidemic over a 7-month period (from May 15 to December 15, 2012). Of 2,808 cholera patients at our hospital, 80 were pregnant, that is, 2.85%. Their mean age was 30 years [range: 15-45 years], 94% were from Conakry (94%), and 69% were in the third trimester of pregnancy. Choleriform diarrhea and vomiting were the main signs, found respectively in 100% and 95% of the women; dehydration was mild for 16%, moderate for 45%, and severe for 39%. Support consisted of rehydration, by plans A (16%), B (45%) or C (39%) and antibiotic treatment based on erythromycin (85%), doxycycline (14%), or azithromycin (1%). Other drugs that were used included phloroglucinol-trimethylphloroglucinol (Spasfon(®)) for 45%, acetaminophen for 65%, and iron/folic acid for 1% of cases. The major obstetric complications were 4 intrauterine deaths (5%), 2 cases of threatened abortion (2%), 1 preterm delivery (1%), and 1 maternal death. The cholera outbreak in 2012 affected a large number of pregnant women in Conakry, most during their third trimester. The classic clinical manifestations were associated with obstetric complications and maternal-fetal risks.
authors.affiliation: Service des maladies infectieuses et tropicales, hôpital national Donka, Conakry, République de Guinée, Université Gamal Abdel Nasser de Conakry, BP 1147 Conakry, République de Guinée, Kipé, rue 177 Kakimbo, commune de Ratoma, BP 5845, Conakry, République de Guinée.
authors.forename: F B
authors.initials: FB
authors.lastname: Sako
authors.affiliation: Service des maladies infectieuses et tropicales, hôpital national Donka, Conakry, République de Guinée, Faculté de médecine, pharmacie, odontostomatologie, université Gamal-Abdel-Nasser, BP 1147 Conakry, République de Guinée.
authors.forename: F A
authors.initials: FA
authors.lastname: Traoré
authors.affiliation: Faculté de médecine, pharmacie, odontostomatologie, université Gamal-Abdel-Nasser, BP 1147 Conakry, République de Guinée, Service de gynéco-obstétrique, hôpital national Donka, Conakry, République de Guinée.
authors.forename: M K
authors.initials: MK
authors.lastname: Camara
authors.affiliation: Service des maladies infectieuses et tropicales, hôpital national Donka, Conakry, République de Guinée.
authors.forename: M
authors.initials: M
authors.lastname: Sylla
authors.affiliation: Service des maladies infectieuses et tropicales, hôpital national Donka, Conakry, République de Guinée, Faculté de médecine, pharmacie, odontostomatologie, université Gamal-Abdel-Nasser, BP 1147 Conakry, République de Guinée.
authors.forename: E F
authors.initials: EF
authors.lastname: Bangoura
authors.affiliation: Service des maladies infectieuses et tropicales, hôpital national Donka, Conakry, République de Guinée.
authors.forename: O
authors.initials: O
authors.lastname: Baldé
mesh_terms: D000293:Adolescent; D000328:Adult; D002771:Cholera / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D058872:Epidemics; D005260:Female; D016701:Guinea / Q000453:epidemiology; D006761:Hospitals; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D012189:Retrospective Studies; D014504:Urban Health; D055815:Young Adult
keywords: Guinea; choléra; epidemic; pregnant women