title: Presynaptic nicotinic cholinoreceptors modulate velocity of the action potential propagation along the motor nerve endings at a high-frequency synaptic activity.
abstract: Experiments on frog neuromuscular junctions have demonstrated that asynchrony of the acetylcholine quantal release forming the multi-quantal evoked response at high-frequency synaptic activity is caused, in particular, by a decrease in velocity of the action potential propagation along the non-myelinated nerve endings, which is mediated by activation of the α7 and α4β4 nicotinic cholinoreceptors.
authors.affiliation: Kazan Institute of Biochemistry and Biophysics, Russian Academy of Sciences, Kazan, Tatarstan, Russia. irina.kovyazina@list.ru.|Kazan Federal University, Kazan, Tatarstan, Russia. irina.kovyazina@list.ru.
authors.forename: I V
authors.initials: IV
authors.lastname: Kovyazina
authors.affiliation: Kazan Institute of Biochemistry and Biophysics, Russian Academy of Sciences, Kazan, Tatarstan, Russia.|Kazan Federal University, Kazan, Tatarstan, Russia.
authors.forename: A N
authors.initials: AN
authors.lastname: Tsentsevitsky
authors.affiliation: Kazan Institute of Biochemistry and Biophysics, Russian Academy of Sciences, Kazan, Tatarstan, Russia.|Kazan Federal University, Kazan, Tatarstan, Russia.|Kazan State Medical University, Kazan, Tatarstan, Russia.
authors.forename: E E
authors.initials: EE
authors.lastname: Nikolsky
mesh_terms: D000109:Acetylcholine / Q000378:metabolism*; D000200:Action Potentials / Q000502:physiology*; D029845:Amphibian Proteins / Q000378:metabolism*; D000818:Animals; D009046:Motor Neurons / Q000378:metabolism*; D011895:Rana ridibunda; D011978:Receptors, Nicotinic / Q000378:metabolism*; D064569:alpha7 Nicotinic Acetylcholine Receptor / Q000378:metabolism*
chemical_list: D029845:Amphibian Proteins; D011978:Receptors, Nicotinic; C427403:alpha(4)beta(4) nicotinic receptor; D064569:alpha7 Nicotinic Acetylcholine Receptor; D000109:Acetylcholine