title: [Experience with the radiosurgical treatment of brain metastases].
abstract: OBJECTIVE
  To analyse the survival rate of a cohort of patients with intracranial metastases treated with radiosurgery, and to determine the factors that influence the results.
  
  
  METHODS
  Retrospective analysis performed on a cohort of 126 patients undergoing radiosurgery for brain metastases. Patients treated with surgery before or after radiosurgery were excluded. Survival is analysed based on clinical (age, sex, primary tumour), radiological (number, location and volume of lesions), and radiotherapy factors (treatment dose, holocraneal radiation). Univariate and multivariate analyses were performed to determine significant prognostic factors.
  
  
  RESULTS
  A total of 225 brain metastases in 126 patients, with a mean age of 59.8±11.6years, were treated between February 2008 and April 2015. The mean survival was 8.2 months. The overall survival rates at 6months, 1year, and 2years were 60.3%, 31.5%, and 12.8%, respectively. Lung (59.5%) and breast (14.3) were the most common primary tumours, and the most common site for metastases was the cerebral hemisphere (77%) and the average volume was 10.35 cc (0.2-43.5). Significant survival factors were: age under 60 (P=.046), female (P<.001), breast cancer (P<.001), KPS >80 (P=.001), SIR6 >5 (P=.031), and GPA ≥2.5 (P=.003).
  
  
  CONCLUSIONS
  Radiosurgery is an appropriate technique for the treatment of brain metastases, and the main prognostic factors include being age under 65, female, breast cancer, and good scores on Karnofsky, SIR, and GPA scales.
authors.affiliation: Departamento de Cirugía, Universidad de Santiago de Compostela, Santiago de Compostela, La Coruña, España.
authors.forename: Pablo
authors.initials: P
authors.lastname: Fernández-de Aspe
authors.affiliation: Departamento de Cirugía, Universidad de Santiago de Compostela, Santiago de Compostela, La Coruña, España.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Fernández-Quinto
authors.affiliation: Departamento de Cirugía, Universidad de Santiago de Compostela, Santiago de Compostela, La Coruña, España.
authors.forename: Andrea
authors.initials: A
authors.lastname: Guerro-Moya
authors.affiliation: Departamento de Cirugía, Universidad de Santiago de Compostela, Santiago de Compostela, La Coruña, España; Servicio de Neurocirugía, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, La Coruña, España.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Arán-Echabe
authors.affiliation: Servicio de Oncología Radioterápica, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, La Coruña, España.
authors.forename: Ana
authors.initials: A
authors.lastname: Varela-Pazos
authors.affiliation: Servicio de Oncología Radioterápica, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, La Coruña, España.
authors.forename: Paula
authors.initials: P
authors.lastname: Peleteiro-Higuero
authors.affiliation: Servicio de Oncología Radioterápica, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, La Coruña, España.
authors.forename: Luis
authors.initials: L
authors.lastname: Cascalla-Caneda
authors.affiliation: Departamento de Cirugía, Universidad de Santiago de Compostela, Santiago de Compostela, La Coruña, España; Servicio de Neurocirugía, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, La Coruña, España. Electronic address: miguel.gelabert@usc.es.
authors.forename: Miguel
authors.initials: M
authors.lastname: Gelabert-González
mesh_terms: D000368:Aged; D001932:Brain Neoplasms / Q000556:secondary* / Q000601:surgery; D002277:Carcinoma / Q000556:secondary / Q000601:surgery; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D017567:Karnofsky Performance Status; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D016634:Radiosurgery / Q000379:methods; D015996:Survival Rate; D016896:Treatment Outcome; D047368:Tumor Burden
keywords: Acelerador lineal; Brain metastases; Linear accelerator; Metástasis cerebral; Oncology; Oncología; Radiocirugía; Radiosurgery; Radioterapia; Radioterapia holocraneal; Radiotherapy; Whole-brain radiation therapy