title: Atrial natriuretic peptide, copeptin and adrenomedullin levels in polycystic ovary syndrome: a case-control study.
abstract: BACKGROUND
  Polycystic ovary syndrome (PCOS) defined by the Rotterdam criteria does not take into account the unhealthy metabolic profile of the syndrome with increased insulin resistance (IR) and overweight favoring development of type 2 diabetes, hypertension and cardiovascular disease (CVD). We assess three vasoactive peptides associated with CVD in women with PCOS.
  
  
  METHODS
  Plasma levels of mid-regional pro-atrial natriuretic peptide (MR-proANP), copeptin and mid-regional pro-adrenomedullin (MR-proADM) were measured in 98 PCOS patients and 46 age- and BMI-matched healthy women.
  
  
  RESULTS
  We found no difference in levels of MR-proANP, copeptin and MR-proADM between the PCOS and control group. Multiple regression analyses on a combined group of PCOS and control subjects demonstrated an inverse correlation between MR-proANP and IR (measured by fasting C-peptide) and a positive correlations between copeptin and IR as well as MR-proADM and BMI. We found no association between peptide levels and different Rotterdam phenotypes.
  
  
  CONCLUSIONS
  Plasma concentrations of MR-proANP, copeptin and MR-proADM were not increased in PCOS compared to age- and BMI-matched controls. Thus, these peptides cannot be used to detect increased risk of CVD in a young PCOS cohort.
authors.affiliation: a Department of Internal Medicine , Division of Endocrinology , and.
authors.forename: Signe
authors.initials: S
authors.lastname: Frøssing
authors.affiliation: b Department of Gynecology and Obstetrics , Herlev University Hospital , Copenhagen , Denmark , and.|c Faculty of Health and Medical Sciences , University of Copenhagen , Copenhagen , Denmark.
authors.forename: Malin
authors.initials: M
authors.lastname: Nylander
authors.affiliation: b Department of Gynecology and Obstetrics , Herlev University Hospital , Copenhagen , Denmark , and.
authors.forename: Mubeena
authors.initials: M
authors.lastname: Aziz
authors.affiliation: b Department of Gynecology and Obstetrics , Herlev University Hospital , Copenhagen , Denmark , and.|c Faculty of Health and Medical Sciences , University of Copenhagen , Copenhagen , Denmark.
authors.forename: Sven O
authors.initials: SO
authors.lastname: Skouby
authors.affiliation: a Department of Internal Medicine , Division of Endocrinology , and.|c Faculty of Health and Medical Sciences , University of Copenhagen , Copenhagen , Denmark.
authors.forename: Caroline
authors.initials: C
authors.lastname: Kistorp
authors.affiliation: a Department of Internal Medicine , Division of Endocrinology , and.|c Faculty of Health and Medical Sciences , University of Copenhagen , Copenhagen , Denmark.
authors.forename: Jens
authors.initials: J
authors.lastname: Faber
mesh_terms: D000293:Adolescent; D053607:Adrenomedullin / Q000097:blood*; D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006020:Glycopeptides / Q000097:blood*; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D055815:Young Adult
chemical_list: D006020:Glycopeptides; C048197:copeptins; D053607:Adrenomedullin; D009320:Atrial Natriuretic Factor
keywords: Adrenomedullin; atrial natriuretic peptide; cardiovascular; copeptin; insulin resistance; polycystic ovary syndrome