title: Cell Type-Specific Differences in Spike Timing and Spike Shape in the Rat Parasubiculum and Superficial Medial Entorhinal Cortex.
abstract: The medial entorhinal cortex (MEC) and the adjacent parasubiculum are known for their elaborate spatial discharges (grid cells, border cells, etc.) and the precessing of spikes relative to the local field potential. We know little, however, about how spatio-temporal firing patterns map onto cell types. We find that cell type is a major determinant of spatio-temporal discharge properties. Parasubicular neurons and MEC layer 2 (L2) pyramids have shorter spikes, discharge spikes in bursts, and are theta-modulated (rhythmic, locking, skipping), but spikes phase-precess only weakly. MEC L2 stellates and layer 3 (L3) neurons have longer spikes, do not discharge in bursts, and are weakly theta-modulated (non-rhythmic, weakly locking, rarely skipping), but spikes steeply phase-precess. The similarities between MEC L3 neurons and MEC L2 stellates on one hand and parasubicular neurons and MEC L2 pyramids on the other hand suggest two distinct streams of temporal coding in the parahippocampal cortex.
authors.affiliation: Bernstein Center for Computational Neuroscience, Humboldt Universität zu Berlin, Philippstr. 13, Haus 6, 10115 Berlin, Germany; Berlin School of Mind and Brain, Humboldt Universität zu Berlin, 10115 Berlin, Germany.
authors.forename: Christian Laut
authors.initials: CL
authors.lastname: Ebbesen
authors.affiliation: Bernstein Center for Computational Neuroscience, Humboldt Universität zu Berlin, Philippstr. 13, Haus 6, 10115 Berlin, Germany; Institute for Theoretical Biology and Department of Biology, Humboldt Universität zu Berlin, 10115 Berlin, Germany.
authors.forename: Eric Torsten
authors.initials: ET
authors.lastname: Reifenstein
authors.affiliation: Bernstein Center for Computational Neuroscience, Humboldt Universität zu Berlin, Philippstr. 13, Haus 6, 10115 Berlin, Germany.
authors.forename: Qiusong
authors.initials: Q
authors.lastname: Tang
authors.affiliation: Werner Reichardt Centre for Integrative Neuroscience, Otfried-Müller-Strass 25, 72076 Tübingen, Germany.
authors.forename: Andrea
authors.initials: A
authors.lastname: Burgalossi
authors.affiliation: Bernstein Center for Computational Neuroscience, Humboldt Universität zu Berlin, Philippstr. 13, Haus 6, 10115 Berlin, Germany.
authors.forename: Saikat
authors.initials: S
authors.lastname: Ray
authors.affiliation: Bernstein Center for Computational Neuroscience, Humboldt Universität zu Berlin, Philippstr. 13, Haus 6, 10115 Berlin, Germany; Institute for Theoretical Biology and Department of Biology, Humboldt Universität zu Berlin, 10115 Berlin, Germany.
authors.forename: Susanne
authors.initials: S
authors.lastname: Schreiber
authors.affiliation: Bernstein Center for Computational Neuroscience, Humboldt Universität zu Berlin, Philippstr. 13, Haus 6, 10115 Berlin, Germany; Institute for Theoretical Biology and Department of Biology, Humboldt Universität zu Berlin, 10115 Berlin, Germany.
authors.forename: Richard
authors.initials: R
authors.lastname: Kempter
authors.affiliation: Bernstein Center for Computational Neuroscience, Humboldt Universität zu Berlin, Philippstr. 13, Haus 6, 10115 Berlin, Germany. Electronic address: michael.brecht@bccn-berlin.de.
authors.forename: Michael
authors.initials: M
authors.lastname: Brecht
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D018728:Entorhinal Cortex / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D051381:Rats; D013826:Theta Rhythm / Q000502:physiology*