title: A biosynthesis-inspired approach to over twenty diverse natural product-like scaffolds.
abstract: A synthetic approach to diverse scaffolds was developed that was inspired by diterpene biosynthesis. Initial scaffolds, generated using Diels-Alder reactions of furyl-functionalised amines, were transformed into alternative scaffolds using cleavage, ring expansion, annulation and rearrangement reactions. In total, 25 diverse scaffolds were prepared that were shown to have high natural product-likeness.
authors.affiliation: School of Chemistry, University of Leeds, Leeds LS2 9JT, UK. a.s.nelson@leeds.ac.uk s.p.marsden@leeds.ac.uk.
authors.forename: James D
authors.initials: JD
authors.lastname: Firth
authors.affiliation: School of Chemistry, University of Leeds, Leeds LS2 9JT, UK. a.s.nelson@leeds.ac.uk s.p.marsden@leeds.ac.uk.
authors.forename: Philip G E
authors.initials: PG
authors.lastname: Craven
authors.affiliation: School of Chemistry, University of Leeds, Leeds LS2 9JT, UK. a.s.nelson@leeds.ac.uk s.p.marsden@leeds.ac.uk.
authors.forename: Matthew
authors.initials: M
authors.lastname: Lilburn
authors.affiliation: Max Planck Institute of Molecular Physiology, Otto-Hahn Strasse 11, 44227 Dortmund, Germany.
authors.forename: Axel
authors.initials: A
authors.lastname: Pahl
authors.affiliation: School of Chemistry, University of Leeds, Leeds LS2 9JT, UK. a.s.nelson@leeds.ac.uk s.p.marsden@leeds.ac.uk.
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Marsden
authors.affiliation: School of Chemistry, University of Leeds, Leeds LS2 9JT, UK. a.s.nelson@leeds.ac.uk s.p.marsden@leeds.ac.uk and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK.
authors.forename: Adam
authors.initials: A
authors.lastname: Nelson
mesh_terms: D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D032701:Biomimetics / Q000379:methods*; D061565:Cycloaddition Reaction / Q000379:methods*; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D013237:Stereoisomerism
chemical_list: D000588:Amines; D001688:Biological Products; D005663:Furans