title: Prostate specific antigen (PSA) in diagnosis of polycystic ovarian syndrome - a new insight.
abstract: BACKGROUND
  Polycystic ovary syndrome (PCOS) is the commonest endocrine disorder and cause of androgen excess in women. Prostate specific antigen (PSA) could be a new marker of hyperandrogenism in PCOS.
  
  
  OBJECTIVE
  The aim of the study was to assess the concentration PSA (total PSA - TPSA and free PSA - fPSA) in 165 patients with PCOS and 40 healthy female controls, the relationship between PSA (TPSA and fPSA) and hormonal parameters and to determine the performance of PSA in diagnosis of PCOS.
  
  
  RESULTS
  Total PSA was higher in PCOS group versus controls. The fPSA was below the lower detection levels among all patients. The median value of FAI was 4.31 in PCOS patients versus 1.79 in controls, p < 0.001. There was a correlation of TPSA and tT (r= 0.173, p = 0.027) and TPSA and FAI (r = 0.2603, p = 0.001). AUC for FAI was 82.1%, threshold 2.56 nmol/l, for tT AUC 80.5%, threshold 0.54 ng/ml, for TPSA AUC 66.3%, threshold 0.005 ng/ml. The ROC analysis for A AUC 62.7%, threshold 3.95 ng/ml.
  
  
  CONCLUSIONS
  PCOS women have higher serum concentration of TPSA than controls. TPSA positively correlate with T and FAI, which is the best marker for hyperandrogenic states and has better accuracy for tT and total PSA serum levels in diagnostic of PCOS.
authors.affiliation: a Department of Gynecological Endocrinology , Medical University of Warsaw , Warsaw , Poland and.
authors.forename: Ewa
authors.initials: E
authors.lastname: Rudnicka
authors.affiliation: b Duchess Anna Mazowiecka Public Teaching Hospital in Warsaw , Warsaw , Poland.
authors.forename: Stanislaw
authors.initials: S
authors.lastname: Radowicki
authors.affiliation: a Department of Gynecological Endocrinology , Medical University of Warsaw , Warsaw , Poland and.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Suchta
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D017430:Prostate-Specific Antigen / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D017430:Prostate-Specific Antigen
keywords: Hyperandrogenism; polycystic ovary syndrome; prostate specific antigen; testosterone