title: Recurrent corneal melting in the paraneoplastic pemphigus associated with Castleman's disease.
abstract: BACKGROUND
  The ocular presentation of Castleman's disease (CD)-associated paraneoplastic pemphigus (PNP) has rarely been reported. In this report, we describe a young patient with CD-associated PNP who had recurrent corneal ulceration in addition to cicatrizing conjunctivitis.
  
  
  METHODS
  We describe a case of 23-year-old male with mucocutaneous erosion and conjunctival injection and erosion who was found to have PNP. Pelvic hyaline-vascular CD was detected and completely excised. The mucocutaneous lesions improved postoperatively. Two years after pelvic surgery, the patient gradually developed conjunctival symblepharon in both eyes and pterygium in the right eye. The patient then underwent a successful exclusion of the symblepharon, an excision of the pterygium and an amniotic membrane transplantation in the right eye. However, after 6 months, he experienced an aseptic corneal ulcer and recurrent pterygiumin the right eye. After treatment with systemic and local immunosuppressive medications, the corneal ulcer gradually healed and remained stable.
  
  
  CONCLUSIONS
  Corneal ulceration and melting, in addition to conjunctivitis, as a complication of CD-associated PNP, can be successfully managed with systemic and local immunosuppressants.
authors.affiliation: Department of Ophthalmology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, 510120, China.
authors.forename: Haijun
authors.initials: H
authors.lastname: Gong
authors.affiliation: Zhongshan Ophthalmic Center, Sun Yat-sen University, State Key Laboratory of Ophthalmology, Guangzhou, 510120, China.
authors.forename: Shiyou
authors.initials: S
authors.lastname: Zhou
authors.affiliation: Department of Ophthalmology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, 510120, China.
authors.forename: Yuxin
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Ophthalmology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, 510120, China.
authors.forename: Yuqin
authors.initials: Y
authors.lastname: Lan
authors.affiliation: Department of Pathology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, 510120, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zeng
authors.affiliation: Department of Dermatology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, 510120, China.
authors.forename: Liangchun
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Radiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, 510120, China.
authors.forename: Qingyu
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Department of Ophthalmology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, 510120, China. 13724856155@163.com.
authors.forename: Mei
authors.initials: M
authors.lastname: Wang
mesh_terms: D005871:Castleman Disease / Q000150:complications*; D003231:Conjunctivitis / Q000209:etiology; D003320:Corneal Ulcer / Q000209:etiology*; D006801:Humans; D008297:Male; D010257:Paraneoplastic Syndromes / Q000150:complications*; D010392:Pemphigus / Q000150:complications*; D011625:Pterygium / Q000209:etiology; D055815:Young Adult
keywords: Castleman’s disease; Corneal melting; Paraneoplastic pemphigus