title: Membrane activity of a supramolecular peptide-based chemotherapeutic enhancer.
abstract: Self-assembly of de novo designed multidomain peptides (MDPs) resulted in functional membrane-active supramolecular nanofibers. The membrane activity was analyzed through fluorescence membrane localization and patch-clamp electrophysiology yielding important information that can be used for the development of a new type of supramolecular peptide-based chemotherapeutic enhancer.
authors.affiliation: Department of Chemistry & Biomolecular Science, Clarkson University, Potsdam, NY 13699, USA. hdong@clarkson.edu.
authors.forename: Dawei
authors.initials: D
authors.lastname: Xu
authors.affiliation: Department of Chemistry & Biomolecular Science, Clarkson University, Potsdam, NY 13699, USA. hdong@clarkson.edu.
authors.forename: Linhai
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Department of Chemistry & Biomolecular Science, Clarkson University, Potsdam, NY 13699, USA. hdong@clarkson.edu.
authors.forename: Louis
authors.initials: L
authors.lastname: DeRidder
authors.affiliation: Department of Chemistry & Biomolecular Science, Clarkson University, Potsdam, NY 13699, USA. hdong@clarkson.edu.
authors.forename: Brendan
authors.initials: B
authors.lastname: Elmore
authors.affiliation: Department of Biology, Clarkson University, Potsdam, NY 13699, USA.
authors.forename: Maurish
authors.initials: M
authors.lastname: Bukhari
authors.affiliation: Department of Chemistry, State University of New York at Binghamton, Binghamton, NY 13902, USA. dsamways@clarkson.edu.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wei
authors.affiliation: Department of Biology, Clarkson University, Potsdam, NY 13699, USA.
authors.forename: Damien S K
authors.initials: DS
authors.lastname: Samways
authors.affiliation: Department of Chemistry & Biomolecular Science, Clarkson University, Potsdam, NY 13699, USA. hdong@clarkson.edu.
authors.forename: He
authors.initials: H
authors.lastname: Dong
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D002462:Cell Membrane / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism*; D002470:Cell Survival / Q000187:drug effects; D057846:Cell-Penetrating Peptides / Q000737:chemistry / Q000494:pharmacology; D004357:Drug Synergism; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000737:chemistry; D008564:Membrane Potentials / Q000187:drug effects; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D057846:Cell-Penetrating Peptides; D008055:Lipids; D010455:Peptides