title: Protection against Radiotherapy-Induced Toxicity.
abstract: Radiation therapy is a highly utilized therapy in the treatment of malignancies with up to 60% of cancer patients receiving radiation therapy as a part of their treatment regimen. Radiation therapy does, however, cause a wide range of adverse effects that can be severe and cause permanent damage to the patient. In an attempt to minimize these effects, a small number of compounds have been identified and are in use clinically for the prevention and treatment of radiation associated toxicities. Furthermore, there are a number of emerging therapies being developed for use as agents that protect against radiation-induced toxicities. The aim of this review was to evaluate and summarise the evidence that exists for both the known radioprotectant agents and the agents that show promise as future radioprotectant agents.
authors.affiliation: Menzies Health Institute Queensland, Griffith University, Gold Coast 4222, Australia. s.hall@griffith.edu.au.|School of Pharmacy, Griffith University, Gold Coast 4222, Australia. s.hall@griffith.edu.au.
authors.forename: Susan
authors.initials: S
authors.lastname: Hall
authors.affiliation: Menzies Health Institute Queensland, Griffith University, Gold Coast 4222, Australia. s.rudrawar@griffith.edu.au.|School of Pharmacy, Griffith University, Gold Coast 4222, Australia. s.rudrawar@griffith.edu.au.
authors.forename: Santosh
authors.initials: S
authors.lastname: Rudrawar
authors.affiliation: Menzies Health Institute Queensland, Griffith University, Gold Coast 4222, Australia. m.zunk@griffith.edu.au.|School of Pharmacy, Griffith University, Gold Coast 4222, Australia. m.zunk@griffith.edu.au.
authors.forename: Matthew
authors.initials: M
authors.lastname: Zunk
authors.affiliation: Menzies Health Institute Queensland, Griffith University, Gold Coast 4222, Australia. n.bernaitis@griffith.edu.au.|School of Pharmacy, Griffith University, Gold Coast 4222, Australia. n.bernaitis@griffith.edu.au.
authors.forename: Nijole
authors.initials: N
authors.lastname: Bernaitis
authors.affiliation: Menzies Health Institute Queensland, Griffith University, Gold Coast 4222, Australia. d.arora@griffith.edu.au.|School of Pharmacy, Griffith University, Gold Coast 4222, Australia. d.arora@griffith.edu.au.
authors.forename: Devinder
authors.initials: D
authors.lastname: Arora
authors.affiliation: Centre for Urology Research, Faculty of Health Sciences and Medicine, Bond University, Robina 4226, Australia. camcderm@bond.edu.au.
authors.forename: Catherine M
authors.initials: CM
authors.lastname: McDermott
authors.affiliation: Menzies Health Institute Queensland, Griffith University, Gold Coast 4222, Australia. s.dukie@griffith.edu.au.|School of Pharmacy, Griffith University, Gold Coast 4222, Australia. s.dukie@griffith.edu.au.
authors.forename: Shailendra
authors.initials: S
authors.lastname: Anoopkumar-Dukie
keywords: inflammation; oxidative stress; radiotherapy; toxicity