title: D-dimers (DD) in CVST.
abstract: OBJECTIVE
  We were interested in further confirming whether D-dimers (DD) are indeed elevated in cerebral venous sinus thrombosis (CVST) as reported in those studies.
  
  
  METHODS
  CVST patients who had a plasma D-dimer test (139 cases) were included and divided into two groups: elevated D-dimer group (EDG) (>0.5 μg/mL; 65 cases) and normal D-dimer group (NDG) (≤0.5 μg/mL; 74 cases). The two groups were compared in terms of demographic data, clinical manifestation, laboratory and imaging data, using inferential statistical methods.
  
  
  RESULTS
  The chi-squared and Fisher exact test showed that, compared to the NDG (74 cases), patients with elevated D-dimer levels were more likely to have a shorter symptom duration (SD) (30 ± 83.9 versus 90 ± 58.9 d, p = 0.003), more risk factors (75.4% versus 52.7%, p = 0.006), higher multiple venous sinus involvement (75.4% versus 59.5%, p = 0.037), increased fibrinogen (43.1% versus 18.9%, p = 0.037) and higher levels of blood glucose (18.3% versus 11%, p = 0.037). According to correlation analyses, D-dimer levels were positively correlated with number of venous sinuses involvement (NVS) (r = 0.321, p = 0.009) in the EDG. Multivariate logistic regression analysis showed that SD (OR, 0.025; 95% CI, 1.324-6.043; p = 0.000), NVS (OR, 1.573; 95% CI, 1.15-2.151; p = 0.005) and risk factors (OR, 3.321; 95% CI, 1.451-7.564; p = 0.004) were significantly different between the two groups.
  
  
  CONCLUSIONS
  D-dimer is elevated in patients with acute/subacute CVST.
authors.affiliation: a Department of Neurology , Chinese People's Liberation Army General Hospital , Beijing , P.R. China.|b Department of Neurology , Shanxi Medical University of First Hospital , Taiyuan , P.R. China.
authors.forename: Hui Fang
authors.initials: HF
authors.lastname: Wang
authors.affiliation: a Department of Neurology , Chinese People's Liberation Army General Hospital , Beijing , P.R. China.
authors.forename: Chuan Qiang
authors.initials: CQ
authors.lastname: Pu
authors.affiliation: a Department of Neurology , Chinese People's Liberation Army General Hospital , Beijing , P.R. China.
authors.forename: Xi
authors.initials: X
authors.lastname: Yin
authors.affiliation: a Department of Neurology , Chinese People's Liberation Army General Hospital , Beijing , P.R. China.
authors.forename: Cheng Lin
authors.initials: CL
authors.lastname: Tian
authors.affiliation: a Department of Neurology , Chinese People's Liberation Army General Hospital , Beijing , P.R. China.|c Department of Neurology , West China Hospital of Sichuan University , Chengdu , P.R. China.
authors.forename: Ting
authors.initials: T
authors.lastname: Chen
authors.affiliation: b Department of Neurology , Shanxi Medical University of First Hospital , Taiyuan , P.R. China.
authors.forename: Jun Hong
authors.initials: JH
authors.lastname: Guo
authors.affiliation: a Department of Neurology , Chinese People's Liberation Army General Hospital , Beijing , P.R. China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Shi
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002784:Cholesterol / Q000097:blood; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D013223:Statistics as Topic; D020246:Venous Thrombosis / Q000097:blood*; D055815:Young Adult
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; D002784:Cholesterol
keywords: D-dimer; blood glucose; cerebral venous sinus thrombosis; number of venous sinuses involvement; symptom duration