title: Synthesis of functionalized amino epoxides by a three-component coupling involving aziridines, arynes and aldehydes.
abstract: A transition-metal-free three-component coupling involving N-substituted aziridines, arynes and aldehydes resulting in the formation of trisubstituted N-aryl α-amino epoxides has been demonstrated. The reaction likely proceeds via the highly strained cyclic nitrogen ylide intermediates generated from aziridines and arynes.
authors.affiliation: Organic Chemistry Division, CSIR-National Chemical Laboratory (CSIR-NCL), Dr. Homi Bhabha Road, Pune-411008, India. at.biju@ncl.res.in.
authors.forename: Tony
authors.initials: T
authors.lastname: Roy
authors.affiliation: Organic Chemistry Division, CSIR-National Chemical Laboratory (CSIR-NCL), Dr. Homi Bhabha Road, Pune-411008, India. at.biju@ncl.res.in.
authors.forename: Manikandan
authors.initials: M
authors.lastname: Thangaraj
authors.affiliation: Centre for Materials Characterization, CSIR-National Chemical Laboratory (CSIR-NCL), Dr. Homi Bhabha Road, Pune-411008, India.
authors.forename: Rajesh G
authors.initials: RG
authors.lastname: Gonnade
authors.affiliation: Organic Chemistry Division, CSIR-National Chemical Laboratory (CSIR-NCL), Dr. Homi Bhabha Road, Pune-411008, India. at.biju@ncl.res.in.
authors.forename: Akkattu T
authors.initials: AT
authors.lastname: Biju