title: Abnormal resting-state brain activity in headache-free migraine patients: A magnetoencephalography study.
abstract: The aim of this study is to quantitatively assess the resting-state brain activity in migraine patients during the headache-free phase with magnetoencephalography (MEG).
  
  
  
  A total of 25 migraine patients during the headache-free phase and 25 gender- and age-matched control patients were studied with a whole-head MEG system at eyes-closed resting-state. MEG data were analyzed in multifrequency range of 4-200Hz.
  
  
  
  In a regional cortex analysis, the spectral power of gamma oscillations in left frontal and left temporal regions was significantly increased in migraine patients as compared to controls (all p<0.001), but no significant difference was found between the two groups for the global channels. Analyses of source location showed that there were significant differences in the distribution of gamma oscillation between migraine subjects and controls (p<0.025).
  
  
  
  Migraine patients in resting-state had altered brain activities in spectral power value and source distribution that can be detected and analyzed by MEG.
  
  
  
  Abnormal brain activities in the left frontal and temporal regions may be involved in pain modulation and processing of migraine. These findings provide new insights into the possible mechanisms of migraine attacks.
authors.affiliation: Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, Jiangsu, People's Republic of China.
authors.forename: Feng
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Xiang
authors.affiliation: The MEG Center, Nanjing Brain Hospital, Nanjing, Jiangsu, People's Republic of China.
authors.forename: Ting
authors.initials: T
authors.lastname: Wu
authors.affiliation: Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, Jiangsu, People's Republic of China.
authors.forename: Donglin
authors.initials: D
authors.lastname: Zhu
authors.affiliation: Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, Jiangsu, People's Republic of China; Department of Neurology, School of Medicine, Nanjing University, No. 22 Hankou Road, Nanjing 210093, People's Republic of China. Electronic address: shijingping@njmu.edu.cn.
authors.forename: Jingping
authors.initials: J
authors.lastname: Shi
mesh_terms: D000328:Adult; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D005260:Female; D006261:Headache / Q000503:physiopathology*; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D008881:Migraine Disorders / Q000503:physiopathology*; D012146:Rest / Q000502:physiology*; D055815:Young Adult
keywords: Gamma oscillation; Magnetoencephalography; Migraine; Resting-state