title: Phasic Burst Stimulation: A Closed-Loop Approach to Tuning Deep Brain Stimulation Parameters for Parkinson's Disease.
abstract: We propose a novel, closed-loop approach to tuning deep brain stimulation (DBS) for Parkinson's disease (PD). The approach, termed Phasic Burst Stimulation (PhaBS), applies a burst of stimulus pulses over a range of phases predicted to disrupt pathological oscillations seen in PD. Stimulation parameters are optimized based on phase response curves (PRCs), which would be measured from each patient. This approach is tested in a computational model of PD with an emergent population oscillation. We show that the stimulus phase can be optimized using the PRC, and that PhaBS is more effective at suppressing the pathological oscillation than a single phasic stimulus pulse. PhaBS provides a closed-loop approach to DBS that can be optimized for each patient.
authors.affiliation: Graduate Program in Neuroscience, University of Minnesota, Minneapolis, Minnesota, United States of America.
authors.forename: Abbey B
authors.initials: AB
authors.lastname: Holt
authors.affiliation: Department of Mechanical Engineering, University of California, Santa Barbara, California, United States of America.
authors.forename: Dan
authors.initials: D
authors.lastname: Wilson
authors.affiliation: Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota, United States of America.
authors.forename: Max
authors.identifier: 0000-0002-7424-4230
authors.initials: M
authors.lastname: Shinn
authors.affiliation: Department of Mechanical Engineering, University of California, Santa Barbara, California, United States of America.
authors.forename: Jeff
authors.initials: J
authors.lastname: Moehlis
authors.affiliation: Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America.
authors.forename: Theoden I
authors.initials: TI
authors.lastname: Netoff
mesh_terms: D000818:Animals; D019295:Computational Biology; D046690:Deep Brain Stimulation; D055724:Electrophysiological Phenomena / Q000502:physiology*; D005917:Globus Pallidus / Q000502:physiology; D006801:Humans; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D010300:Parkinson Disease / Q000628:therapy*; D011323:Primates