title: Alpha-mangostin attenuates brain inflammation induced by peripheral lipopolysaccharide administration in C57BL/6J mice.
abstract: Neuroinflammation is an important feature in the pathogenesis and progression of neurodegenerative diseases. Molecules with anti-inflammatory properties have been evaluated in animal models of neuroinflammation and neurodegeneration as an adjuvant therapeutic strategy. In the present study we have demonstrated that alpha-mangostin (α-MG), a natural xanthone purified from mangosteen pericarp, reduced brain levels of pro-inflammatory cytokine interleukin-6 (IL-6), cyclooxygenase-2 (COX-2) and 18 kDa translocator protein (TSPO) in an animal model of peripheral LPS-induced neuroinflammation. We think that evaluation of α-MG as an adjuvant treatment in preclinical models of AD, PD, multiple sclerosis and other diseases with known shared pathology merits further consideration.
authors.affiliation: Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico (UNAM), Apartado Postal 70228, Cuidad Universitaria, Mexico, DF 04510, Mexico.
authors.forename: Miryam
authors.initials: M
authors.lastname: Nava Catorce
authors.affiliation: Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico (UNAM), Apartado Postal 70228, Cuidad Universitaria, Mexico, DF 04510, Mexico.
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Acero
authors.affiliation: Departamento de Biologia, Facultad de Quimica, Universidad Nacional Autonoma de Mexico (UNAM), Apartado Postal 70228, Cuidad Universitaria, Mexico, DF, 04510, Mexico.
authors.forename: José
authors.initials: J
authors.lastname: Pedraza-Chaverri
authors.affiliation: Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico (UNAM), Apartado Postal 70228, Cuidad Universitaria, Mexico, DF 04510, Mexico.
authors.forename: Gladis
authors.initials: G
authors.lastname: Fragoso
authors.affiliation: Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico (UNAM), Apartado Postal 70228, Cuidad Universitaria, Mexico, DF 04510, Mexico.
authors.forename: Tzipe
authors.initials: T
authors.lastname: Govezensky
authors.affiliation: Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico (UNAM), Apartado Postal 70228, Cuidad Universitaria, Mexico, DF 04510, Mexico. Electronic address: gokar@unam.mx.
authors.forename: Goar
authors.initials: G
authors.lastname: Gevorkian
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002135:Calcium-Binding Proteins / Q000378:metabolism; D051546:Cyclooxygenase 2 / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D004660:Encephalitis / Q000139:chemically induced* / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D008070:Lipopolysaccharides / Q000633:toxicity*; D051379:Mice; D008810:Mice, Inbred C57BL; D008840:Microfilament Proteins / Q000378:metabolism; D017628:Microglia / Q000187:drug effects; D018079:Receptors, GABA / Q000378:metabolism; D044004:Xanthones / Q000627:therapeutic use*
chemical_list: C491049:Aif1 protein, mouse; D000893:Anti-Inflammatory Agents; C463819:Bzrp protein, mouse; D002135:Calcium-Binding Proteins; D016207:Cytokines; D005904:Glial Fibrillary Acidic Protein; D008070:Lipopolysaccharides; D008840:Microfilament Proteins; D018079:Receptors, GABA; D044004:Xanthones; D051546:Cyclooxygenase 2; C021053:mangostin
keywords: Cyclooxygenase-2; Interleukin-6; Lipopolysaccharide; Neuroinflammation; Peripheral infection; α-Mangostin