title: T-cell/histiocyte-rich large B-cell lymphoma of stomach.
abstract: T-cell/histiocyte-rich large B-cell lymphoma is an unusually encountered lymphoid neoplasm of stomach with aggressive course, and is an uncommon morphologic variant of diffuse large B-cell lymphoma. An ulcerated mass, 7x5x1 cm in size was observed within the gastrectomy specimen of a 76-year-old female patient. In cross sections, besides mature lymphoid cells displaying T-cell phenotype, a neoplastic formation composed of large, pleomorphic atypical lymphoid cells with, prominent nucleoli, vesicular nuclei and abundant eosinophilic cytoplasm displaying B-cell phenotype were observed. Meanwhile, histiocyte-like mononuclear cells and Reed-Sternberg-like multinuclear cells expressing CD68 and Mac387 were also observed. The diagnosis of the case was T cell/histiocyte-rich large B-cell lymphoma. This rarely encountered neoplasm should be kept in mind in the differential diagnosis of primary gastric lymphomas.
authors.affiliation: Department of Pathology, Faculty of Medicine, Bulent Ecevit University (Former: Zonguldak Karaelmas Unviersity), Zonguldak, Turkey.
authors.forename: Figen
authors.initials: F
authors.lastname: Barut
authors.affiliation: Department of Pathology, Faculty of Medicine, Bulent Ecevit University (Former: Zonguldak Karaelmas Unviersity), Zonguldak, Turkey.
authors.forename: Nilufer Onak
authors.initials: NO
authors.lastname: Kandemir
authors.affiliation: Department of Pathology, Faculty of Medicine, Bulent Ecevit University (Former: Zonguldak Karaelmas Unviersity), Zonguldak, Turkey.
authors.forename: Banu Dogan
authors.initials: BD
authors.lastname: Gun
authors.affiliation: Department of Pathology, Faculty of Medicine, Bulent Ecevit University (Former: Zonguldak Karaelmas Unviersity), Zonguldak, Turkey.
authors.forename: Sukru Oguz
authors.initials: SO
authors.lastname: Ozdamar
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D005743:Gastrectomy / Q000379:methods*; D006644:Histiocytes / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D009367:Neoplasm Staging; D013270:Stomach / Q000473:pathology / Q000601:surgery; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D013601:T-Lymphocytes / Q000473:pathology*
keywords: T-cell/histiocyte-rich large B-cell lymphoma; diffuse large B-cell lymphoma; gastric malignancies.