title: Spectrum of Childhood Tuberculosis in BCG Vaccinated and Unvaccinated Children.
abstract: BACKGROUND
  Childhood tuberculosis remains a major public health problem in India. We evaluated the impact of BCG vaccination on childhood tuberculosis and the underlying risk factors.
  
  
  METHODS
  100 consecutive children below 12 years diagnosed to have tuberculosis based on the WHO and IAP consensus statement were included in the study.
  
  
  RESULTS
  Majority(42%) of children with tuberculosis were below four years of age. History of contact with a case of tuberculosis was present in 41 cases. BCG scar was present in 77 cases indicating a poor coverage/uptake of BCG vaccination. Pulmonary form of tuberculosis was seen in 52 and extra pulmonary form in 41 cases. Tubercular lymphadenitis was seen in seven cases, of which more than 70 % were in BCG vaccinated group. There was no statistically significant difference in the type of tuberculosis (pulmonary or extra pulmonary) and BCG vaccination. In the extra pulmonary form, 13 children had neuro-tuberculosis, of which 66% were in BCG unvaccinated group, which was statistically significant (p=0.011). The underlying risk factors were poor socioeconomic status (62%), malnutrition (61%) and poor immunization coverage.
  
  
  CONCLUSIONS
  Higher incidence of pulmonary tuberculosis in BCG vaccinated group was not statistically significant. However, high incidence of neuro-tuberculosis in BCG unvaccinated group was statistically significant. The underlying risk factors were poor socio-economic status, malnutrition and poor immunization coverage and should be taken into consideration in order to prevent morbidity and mortality due to tuberculosis in children.
authors.affiliation: Associate Professor, (Department of Pediatrics), AFMC, Pune.
authors.forename: R
authors.initials: R
authors.lastname: Gupta
authors.affiliation: Graded Specialist (Pediatrics), 7 Air Force Hospital, Kanpur.
authors.forename: A
authors.initials: A
authors.lastname: Garg
authors.affiliation: Associate Professor, (Department of Pediatrics), AFMC, Pune.
authors.forename: V
authors.initials: V
authors.lastname: Venkateshwar
authors.affiliation: Professor & Head (Department of Pediatrics), AFMC, Pune.
authors.forename: M
authors.initials: M
authors.lastname: Kanitkar
keywords: Bacille Calmette Guerin vaccine; Tuberculosis