title: Lower Serum Levels of Uric Acid in Uterine Fibroids and Fibrocystic Breast Disease Patients in Dongying City, China.
abstract: BACKGROUND
  Increasing serum levels of uric acid (SUA) after menopause in women brought up a hypothesis that estrogenic effect may protectively regulate SUA. Estrogenic effect is a major etiology of uterine fibroids and fibrocystic breast disease. The study aimed to explore SUA among patients suffering from these diseases to enhance the hypothesis.
  
  
  METHODS
  Overall, 1349 female participants were selected into three cases: Case I having uterine fibroids (n=568), Case II having fibrocycstic breast disease (n=608) and Case III having uterine fibroids combining with fibrocycstic breast disease (n=173); 4206 participants without these diseases were selected as controls. Based on health check-up data from 2011 to 2012, in Dongying Shengli Oilfield Central Hospital, a cross-sectional study was conducted to examine the difference in SUA between the case and control. We adjusted covariates by generalized linear regression mode.
  
  
  RESULTS
  From 19 to 44 yr, SUA of Case I to Case III were lower than controls by 8.46 umol/L (P=0.011), 5.88umol/L (P=0.014) and 9.39 umol/L (P=0.059), respectively. From 45-54 yr, no significant differences were between three cases and controls. In Case I and its control: from 54-59 yr, differences were not significant; from 60 to 72 yr, SUA in Case I was lower than the control by 32.02umol/L (P=0.003).
  
  
  CONCLUSIONS
  Participants of uterine fibroids and fibrocystic breast disease had a lower SUA except the stage of menopause, which indirectly supported that estrogenic effect, may protectively decrease SUA.
authors.affiliation: Dept. of Prevention and Health Care, Dongying Shengli Oilfield Central Hospital, Dongying, China.
authors.forename: Qicai
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Dept. of Epidemiology and Biostatistics, School of Public Health, Shandong University, Jinan, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Xiao
authors.affiliation: Dept. of Epidemiology and Biostatistics, School of Public Health, Shandong University, Jinan, China; Tianjin Entry-Exit Inspections and Quarantine Bureau, Tianjin, China.
authors.forename: Pengpeng
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Dept. of Epidemiology and Biostatistics, School of Public Health, Shandong University, Jinan, China; Dept. of Nutrition and Food Safety, Zhejiang Center for Disease Control and Prevention, Hangzhou, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Chen
authors.affiliation: Dept. of Epidemiology and Biostatistics, School of Public Health, Shandong University, Jinan, China.
authors.forename: Xiaoxiao
authors.initials: X
authors.lastname: Chen
authors.affiliation: Dept. of Epidemiology and Biostatistics, School of Public Health, Shandong University, Jinan, China.
authors.forename: Shumei
authors.initials: S
authors.lastname: Wang
keywords: Breast disease; Estrogenic effect; Leiomyoma and fibrocyst; Uric acid