title: DTI Analysis of Presbycusis Using Voxel-Based Analysis.
abstract: OBJECTIVE
  Presbycusis is the most common sensory deficit in the aging population. A recent study reported using a DTI-based tractography technique to identify a lack of integrity in a portion of the auditory pathway in patients with presbycusis. The aim of our study was to investigate the white matter pathology of patients with presbycusis by using a voxel-based analysis that is highly sensitive to local intensity changes in DTI data.
  
  
  METHODS
  Fifteen patients with presbycusis and 14 age- and sex-matched healthy controls were scanned on a 3T scanner. Fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity were obtained from the DTI data. Intergroup statistics were implemented on these measurements, which were transformed to Montreal Neurological Institute coordinates by using a nonrigid image registration method called large deformation diffeomorphic metric mapping.
  
  
  RESULTS
  Increased axial diffusivity, radial diffusivity, and mean diffusivity and decreased fractional anisotropy were found near the right-side hearing-related areas in patients with presbycusis. Increased radial diffusivity and mean diffusivity were also found near a language-related area (Broca area) in patients with presbycusis.
  
  
  CONCLUSIONS
  Our findings could be important for exploring reliable imaging evidence of presbycusis and could complement an ROI-based approach.
authors.affiliation: From the Department of Otolaryngology (W.M., L.S.).|the Second Hospital of Shandong University, The Central Hospital of Jinan City (W.M., L.Y.).
authors.forename: W
authors.identifier: http://orcid.org/0000-0003-4673-6198
authors.initials: W
authors.lastname: Ma
authors.affiliation: College of Electronics and Information Engineering (M.L.), Sichuan University, Chengdu, China.
authors.forename: M
authors.identifier: http://orcid.org/0000-0003-3596-9287
authors.initials: M
authors.lastname: Li
authors.affiliation: Shandong Medical Imaging Research Institute (F.G., X.Z., B.Z., G.W.), Shandong University, Jinan, China.
authors.forename: F
authors.identifier: http://orcid.org/0000-0002-4343-0276
authors.initials: F
authors.lastname: Gao
authors.affiliation: Shandong Medical Imaging Research Institute (F.G., X.Z., B.Z., G.W.), Shandong University, Jinan, China.
authors.forename: X
authors.identifier: http://orcid.org/0000-0002-0075-748X
authors.initials: X
authors.lastname: Zhang
authors.affiliation: From the Department of Otolaryngology (W.M., L.S.).
authors.forename: L
authors.identifier: http://orcid.org/0000-0003-4426-1774
authors.initials: L
authors.lastname: Shi
authors.affiliation: the Second Hospital of Shandong University, The Central Hospital of Jinan City (W.M., L.Y.).
authors.forename: L
authors.identifier: http://orcid.org/0000-0001-8048-8242
authors.initials: L
authors.lastname: Yu
authors.affiliation: Shandong Medical Imaging Research Institute (F.G., X.Z., B.Z., G.W.), Shandong University, Jinan, China.
authors.forename: B
authors.identifier: http://orcid.org/0000-0002-3489-9435
authors.initials: B
authors.lastname: Zhao
authors.affiliation: Philips Healthcare (W.C.), Shanghai, China.
authors.forename: W
authors.identifier: http://orcid.org/0000-0002-4727-3642
authors.initials: W
authors.lastname: Chen
authors.affiliation: Shandong Medical Imaging Research Institute (F.G., X.Z., B.Z., G.W.), Shandong University, Jinan, China wgb7932596@hotmail.com.
authors.forename: G
authors.identifier: http://orcid.org/0000-0001-7410-5540
authors.initials: G
authors.lastname: Wang
authors.affiliation: the Department of Radiation Oncology (X.W.), University of Nebraska Medical Center, Omaha, Nebraska.
authors.forename: X
authors.identifier: http://orcid.org/0000-0002-9519-8413
authors.initials: X
authors.lastname: Wang