title: Folic Acid-Functionalized Polythiophene for Targeted Cellular Imaging.
abstract: Polythiophene containing pendant N-hydroxysuccinimide (NHS) ester groups was reacted with poly(ethylene glycol) (PEG) and oleylamine, which was subsequently modified with folic acid to prepare a targeting fluorescent cellular imaging probe. The amphiphilic character of the folic acid-functionalized polythiophene induced the formation of nanoparticles with an average diameter of 95.3 nm in water. This polymer shows good photostability and low toxicity toward KB cells at a high concentration (100 µg/mL), which meets the crucial requirement for cellular imaging and other biological applications. The folic acid-functionalized polythiophene could be internalized efficiently into KB cells and accumulated in the cytoplasm to yield bright fluorescence, indicating that it is a good candidate material for the fluorescence imaging of living cells.
authors.forename: Hyun-Chul
authors.initials: HC
authors.lastname: Kim
authors.forename: Eunjoo
authors.initials: E
authors.lastname: Kim
authors.forename: Se Guen
authors.initials: SG
authors.lastname: Lee
authors.forename: Sung Jun
authors.initials: SJ
authors.lastname: Lee
authors.forename: Sang Won
authors.initials: SW
authors.lastname: Jeong
authors.forename: Tae-Lin
authors.initials: TL
authors.lastname: Hal
authors.forename: Boram
authors.initials: B
authors.lastname: Lee
authors.forename: Seung Woo
authors.initials: SW
authors.lastname: Lee
mesh_terms: D016503:Drug Delivery Systems / Q000379:methods*; D005492:Folic Acid / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007624:KB Cells; D008422:Materials Testing; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology; D013876:Thiophenes / Q000737:chemistry / Q000494:pharmacology
chemical_list: D011108:Polymers; D013876:Thiophenes; C066730:polythiophene; D005492:Folic Acid