title: Adaptation and validation of an Italian version of the Prostate Cancer Specific Quality of Life Instrument (PROSQOLI).
abstract: The Prostate Cancer Specific Quality of Life Instrument (PROSQOLI) is a measure of health-related quality of life (HRQoL) in advanced hormone-resistant prostate cancer. In this study, we aimed at performing a cross-cultural adaptation and validation of the Italian version of the PROSQOLI.
  
  
  
  The original version of the PROSQOLI underwent several turnarounds of translations. A total of 472 patients treated with radical prostatectomy, radiotherapy or medical therapy were enrolled for the validation of the questionnaire. The PROSQOLI was administered together with the SF-12. Reliability indexes were calculated by using Cronbach alpha. To evaluate the validity of the construct, relationships between PROSQOLI and SF12 were assessed. The ANOVA test was used to evaluate the differences between groups of patients who had received different treatments.
  
  
  
  The reliability coefficient was 0.91. Item-to-total correlation indices were in most cases >0.70. The correlation between the scores of the PROSQOLI and those of the SF-12 questionnaire was high (r=0.8139, p<0.0001). The ANOVA test showed significant differences between groups (p<0.01) based on age, recurrence risk and treatment.
  
  
  
  The adaptation process showed that the PROSQOLI Italian version has high reliability and presents both convergent and discriminant validity. This version of the tool can be used to assess HRQoL in Italian men who underwent radical treatment for advanced prostate cancer.
authors.affiliation: Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. Lara.belladita@istitutotumori.mi.it.
authors.forename: L
authors.initials: L
authors.lastname: Bellardita
authors.forename: R
authors.initials: R
authors.lastname: Damiano
authors.forename: F
authors.initials: F
authors.lastname: Porpiglia
authors.forename: V
authors.initials: V
authors.lastname: Scattoni
authors.forename: A
authors.initials: A
authors.lastname: Amodeo
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authors.initials: R
authors.lastname: Bortolus
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authors.initials: A
authors.lastname: Lapini
authors.forename: A
authors.initials: A
authors.lastname: Cocci
authors.forename: V
authors.initials: V
authors.lastname: Cicalese
authors.forename: M
authors.initials: M
authors.lastname: Caponera
authors.forename: P
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authors.lastname: Mastrangelo
authors.forename: F
authors.initials: F
authors.lastname: Francesca
authors.forename: R
authors.initials: R
authors.lastname: Valdagni
authors.forename: G
authors.initials: G
authors.lastname: Taverna
authors.forename: D
authors.initials: D
authors.lastname: di Trapani
authors.forename: R
authors.initials: R
authors.lastname: Leonardi
authors.forename: D
authors.initials: D
authors.lastname: Minocci
authors.forename: F
authors.initials: F
authors.lastname: Gaboardi
authors.forename: E
authors.initials: E
authors.lastname: Montanari
authors.forename: G
authors.initials: G
authors.lastname: Conti
mesh_terms: D006801:Humans; D007558:Italy; D008297:Male; D011471:Prostatic Neoplasms / Q000628:therapy*; D011788:Quality of Life; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires