title: Cycloplegic effect of atropine compared with cyclopentolate-tropicamide combination in children with hypermetropia.
abstract: BACKGROUND
  Cycloplegic refraction is important in assessing children with hypermetropia. Atropine, though the gold standard cycloplegic agent for refraction in children, has a long duration of action and more severe side effects compared to short-acting cycloplegic agents. The aim of the study was to compare the cycloplegic effect of atropine with cyclopentolate and tropicamide combination in children with hypermetropia.
  
  
  METHODS
  This was a crossover interventional study in children with hypermetropia. Cycloplegic refraction using two separate regimens of cycloplegic drugs was done on all subjects. Data were analyzed using the statistical software SPSS version 22.0. The mean spherical equivalent values of regimen 1 (atropine 1%) and regimen 2 (cyclopentolate 1% and tropicamide 1%) were presented as mean and standard deviation. A P ≤ 0.05 was considered statistically significant.
  
  
  RESULTS
  One hundred and twenty-six eyes of 63 subjects aged 5-12 years were examined. The mean spherical equivalent values for regimen 1 and regimen 2 for the right eyes were 4.73 ± 2.1 DS and 4.54 ± 1.9 DS, respectively (P = 0.59). The mean spherical equivalent values for regimens 1 and 2 for the left eyes were 4.74 ± 2.0 DS and 4.54 ± 1.8 DS, respectively (P = 0.56).
  
  
  CONCLUSIONS
  The combination of 1% cyclopentolate and 1% tropicamide could be a useful alternative to atropine 1% for cycloplegic refraction in children with hypermetropia.
authors.affiliation: Department of Ophthalmology, Faculty of Clinical Sciences, College of Health Sciences, Bayero University/Aminu Kano Teaching Hospital, Kano, Nigeria.
authors.forename: Rabi Yahaya
authors.initials: RY
authors.lastname: Sani
authors.affiliation: Department of Ophthalmology, Faculty of Clinical Sciences, College of Health Sciences, Bayero University/Aminu Kano Teaching Hospital, Kano, Nigeria.
authors.forename: Sadiq
authors.initials: S
authors.lastname: Hassan
authors.affiliation: Department of Ophthalmology, Faculty of Clinical Sciences, College of Health Sciences, Bayero University/Aminu Kano Teaching Hospital, Kano, Nigeria.
authors.forename: Saudat Garba
authors.initials: SG
authors.lastname: Habib
authors.affiliation: Department of Ophthalmology, Aminu Kano Teaching Hospital, Kano, Nigeria.
authors.forename: Ebisike Philips
authors.initials: EP
authors.lastname: Ifeanyichukwu
keywords: Atropine; cyclopentolate; cycloplegic refraction; hypermetropia; tropicamide