title: Serum and vitreous fibulin-1 concentrations in patients with diabetic retinopathy.
abstract: Fibulin-1, an extracellular matrix glycoprotein, is closely correlated with angiogenesis. The purpose of this investigation is to determine serum and vitreous fibulin-1 concentrations in diabetic retinopathy (DR). This cross-sectional investigation was carried out in a population of 154 diabetic patients (54 without DR, 42 with non-proliferative diabetic retinopathy (NPDR) and 58 with proliferative diabetic retinopathy (PDR)) and 49 control subjects. The diabetic group showed higher serum and vitreous fibulin-1 concentrations than the controls. Serum and vitreous fibulin-1 concentrations in PDR patients were significantly elevated compared with those in the other 3 groups. NPDR patients showed elevated levels of serum and vitreous fibulin-1 concentrations compared with patients without DR. Logistic regression analysis revealed that serum and vitreous fibulin-1 were risk factors for developing DR. Pearson correlation analysis showed that serum fibulin-1 was correlated with systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting plasma glucose and vitreous fibulin-1. Furthermore, Pearson correlation analysis showed that vitreous fibulin-1 was correlated with SBP, DBP, high-density lipoprotein cholesterol and serum fibulin-1. Serum and vitreous fibulin-1 concentrations are elevated under DR condition.
authors.affiliation: Department of Laboratory, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China.
authors.forename: Meiling
authors.initials: M
authors.lastname: Tian
authors.affiliation: Department of Ophthalmology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Anesthesiology, The Third People's Hospital of Jinan, Jinan, People's Republic of China.
authors.forename: Yuqin
authors.initials: Y
authors.lastname: Wei
authors.affiliation: Department of Laboratory, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China.
authors.forename: Qingle
authors.initials: Q
authors.lastname: Lu
authors.affiliation: Department of Laboratory, Yuhuangding Hospital, Yantai, People's Republic of China.
authors.forename: Baohua
authors.initials: B
authors.lastname: Huang
mesh_terms: D002135:Calcium-Binding Proteins / Q000097:blood*; D003430:Cross-Sectional Studies; D003930:Diabetic Retinopathy / Q000097:blood*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D014822:Vitreous Body / Q000378:metabolism*
chemical_list: D002135:Calcium-Binding Proteins; C060820:fibulin
keywords: Diabetes Complications; Diabetes Mellitus