title: Retrospective Evaluation of Nail Trimming as a Conservative Treatment for Ulcerative Dermatitis in Laboratory Mice.
abstract: Ulcerative dermatitis (UD) is an idiopathic disease that affects C57BL/6 mice and those having a B6 background. The hallmark of UD is pruritus, which leads to self-mutilation and epidermal ulceration typically in the intrascapular region. Although several treatments for UD have been published, some involve the use of pharmacologic agents that might confound research results. In this retrospective study, we evaluated nail trimming to determine whether this conservative treatment approach improved the resolution rate of UD at our institution compared with that of untreated mice or those that received oral or topical antibiotics. Our findings show that the incidence of resolution of UD was significantly greater and that the time to resolution was shorter in mice treated with nail trimming compared with other groups. These findings support the use of nail trimming as an effective conservative treatment option for UD in B6 mice.
authors.affiliation: Department of Veterinary Pathobiology, Comparative Medicine Program, University of Missouri-Columbia, Columbia, Missouri, USA; The Jackson Laboratory, Bar Harbor, Maine, USA. Cynthiagalvarado@gmail.com.
authors.forename: Cynthia G
authors.initials: CG
authors.lastname: Alvarado
authors.affiliation: Department of Veterinary Pathobiology, Comparative Medicine Program, University of Missouri-Columbia, Columbia, Missouri, USA.
authors.forename: Craig L
authors.initials: CL
authors.lastname: Franklin
authors.affiliation: Office of Animal Resources, University of Missouri-Columbia, Columbia, Missouri, USA.
authors.forename: Lonny W
authors.initials: LW
authors.lastname: Dixon
mesh_terms: D000818:Animals; D000072700:Conservative Treatment / Q000662:veterinary; D003872:Dermatitis / Q000662:veterinary*; D005260:Female; D006724:Hoof and Claw; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012189:Retrospective Studies; D012376:Rodent Diseases / Q000628:therapy*; D012883:Skin Ulcer / Q000662:veterinary*