title: Enhancing tumor penetration and targeting using size-minimized and zwitterionic nanomedicines.
authors.affiliation: Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, Nanjing University, Nanjing 210023, China.
authors.forename: Yajun
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, Nanjing University, Nanjing 210023, China.
authors.forename: Weizhi
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, Nanjing University, Nanjing 210023, China.
authors.forename: Chenchen
authors.initials: C
authors.lastname: Yang
authors.affiliation: Key Lab Organ Elect & Informat Displays, Nanjing University Posts & Telecommun, Nanjing 210023, China.
authors.forename: Quli
authors.initials: Q
authors.lastname: Fan
authors.affiliation: Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, Nanjing University, Nanjing 210023, China. Electronic address: wuwei@nju.edu.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.affiliation: Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, Nanjing University, Nanjing 210023, China. Electronic address: jiangx@nju.edu.cn.
authors.forename: Xiqun
authors.initials: X
authors.lastname: Jiang
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D001622:Betaine / Q000031:analogs & derivatives*; D001897:Boronic Acids / Q000737:chemistry; D045744:Cell Line, Tumor; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004317:Doxorubicin / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D051379:Mice; D050997:Nanomedicine; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*
chemical_list: D000903:Antibiotics, Antineoplastic; D001897:Boronic Acids; D003692:Delayed-Action Preparations; D011108:Polymers; D001622:Betaine; D011092:Polyethylene Glycols; D004317:Doxorubicin; C010686:benzeneboronic acid
keywords: Drug delivery; Multiarm block copolymer; Polyzwitterion; Size effect; Surface chemistry; Tumor penetration