title: Pancreatic neuroendocrine tumors: contemporary diagnosis and management.
abstract: Pancreatic neuroendocrine tumors (PNETs) are neoplasms that arise from the hormone producing cells of the islets of Langerhans, also known as pancreatic islet cells. PNETs are considered a subgroup of neuroendocrine tumors, and have unique biology, natural history and clinical management. These tumors are classified as 'functional' or 'non-functional' depending on whether they release peptide hormones that produce specific hormone- related symptoms, usually in established patterns based on tumor subtype. This manuscript will review pancreatic neuroendocrine tumor subtypes, syndromes, diagnosis, and clinical management.
authors.affiliation: a Department of Internal Medicine, Division of Gastroenterology and Hepatology , University of Utah School of Medicine, Huntsman Cancer Center , Salt Lake City , Utah , USA.
authors.forename: Sheeva K
authors.initials: SK
authors.lastname: Parbhu
authors.affiliation: a Department of Internal Medicine, Division of Gastroenterology and Hepatology , University of Utah School of Medicine, Huntsman Cancer Center , Salt Lake City , Utah , USA.
authors.forename: Douglas G
authors.initials: DG
authors.lastname: Adler
mesh_terms: D018273:Carcinoma, Islet Cell / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D007340:Insulinoma / Q000503:physiopathology / Q000628:therapy; D007515:Islets of Langerhans; D018761:Multiple Endocrine Neoplasia Type 1 / Q000503:physiopathology / Q000628:therapy; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D018358:Neuroendocrine Tumors / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D010187:Pancreatic Hormones; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D036361:Peptide Hormones; D044469:Racial Groups; D012737:Sex Factors
chemical_list: D010187:Pancreatic Hormones; D036361:Peptide Hormones
keywords: Pancreatic neuroendocrine tumors; VIPoma; gastrinoma; glucagonoma; insulinoma; somatostatinoma