title: Expression of P2 Purinergic Receptors in Mesenchymal Stem Cells and Their Roles in Extracellular Nucleotide Regulation of Cell Functions.
abstract: Extracellular ATP and other nucleotides induce autocrine and/or paracrine purinergic signalling via activation of the P2 receptors on the cell surface, which represents one of the most common signalling mechanisms. Mesenchymal stem cells (MSC) are a type of multipotent adult stem cells that have many promising applications in regenerative medicine. There is increasing evidence to show that extracellular nucleotides regulate MSC functions and P2 receptor-mediated purinergic signalling plays an important role in such functional regulation. P2 receptors comprise ligand-gated ion channel P2X receptors and G-protein-coupled P2Y receptors. In this review, we provide an overview of the current understanding with respect to expression of the P2X and P2Y receptors in MSC and their roles in mediating extracellular nucleotide regulation of MSC proliferation, migration and differentiation. J. Cell. Physiol. 232: 287-297, 2017. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Faculty of Biological Sciences, School of Biomedical Sciences, University of Leeds, Leeds, United Kingdom. l.h.jiang@leeds.ac.uk.|Department of Physiology and Neurobiology, Xinxiang Medical University, Xinxiang, China. l.h.jiang@leeds.ac.uk.
authors.forename: Lin-Hua
authors.initials: LH
authors.lastname: Jiang
authors.affiliation: Faculty of Biological Sciences, School of Biomedical Sciences, University of Leeds, Leeds, United Kingdom.
authors.forename: Yunjie
authors.initials: Y
authors.lastname: Hao
authors.affiliation: Faculty of Biological Sciences, School of Biomedical Sciences, University of Leeds, Leeds, United Kingdom.
authors.forename: Fatema
authors.initials: F
authors.lastname: Mousawi
authors.affiliation: Department of Physiology and Neurobiology, Xinxiang Medical University, Xinxiang, China.
authors.forename: Hongsen
authors.initials: H
authors.lastname: Peng
authors.affiliation: Faculty of Medicine and Health, Department of Oral Biology, University of Leeds, Leeds, United Kingdom.
authors.forename: Xuebin
authors.initials: X
authors.lastname: Yang
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D005110:Extracellular Space / Q000378:metabolism*; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism*; D009711:Nucleotides / Q000378:metabolism*; D018048:Receptors, Purinergic P2 / Q000378:metabolism*
chemical_list: D009711:Nucleotides; D018048:Receptors, Purinergic P2