title: Thoracic Myelopathy Due to Gnathostomiasis Acquired in New Zealand.
abstract: Gnathostomiasis is a zoonotic disease endemic in Asia. It most commonly manifests as gastrointestinal and cutaneous disease. Central nervous system involvement is a rare but feared complication, often leaving patients with permanent neurologic deficits. Clinicians outside of Asia and Latin America may have little experience with this illness, causing delays in diagnosis and treatment. We describe a 40-year-old woman who developed a progressive myelopathy over 18 months. She had never traveled outside of New Zealand. Cerebrospinal fluid (CSF) showed marked eosinophilia and Gnathostoma serology was positive in both serum and CSF. This is the first report of gnathostomiasis acquired in New Zealand, and the first case of neurognathostomiasis reported outside Asia. Clinicians should include neurognathostomiasis in the differential diagnosis of myelopathy and CSF eosinophilia, even if there is no history of travel to endemic areas.
authors.affiliation: Department of Neurology, Auckland City Hospital, Auckland, New Zealand. eoinM@adhb.govt.nz.
authors.forename: Eoin
authors.initials: E
authors.lastname: Mulroy
authors.affiliation: Department of Neurology, Auckland City Hospital, Auckland, New Zealand.
authors.forename: Mark
authors.initials: M
authors.lastname: Simpson
authors.affiliation: Department of Neurology, Auckland City Hospital, Auckland, New Zealand.
authors.forename: Richard
authors.initials: R
authors.lastname: Frith
mesh_terms: D000328:Adult; D004802:Eosinophilia / Q000134:cerebrospinal fluid; D005260:Female; D058429:Gnathostomiasis / Q000134:cerebrospinal fluid / Q000150:complications / Q000000981:diagnostic imaging*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009187:Myelitis / Q000134:cerebrospinal fluid / Q000150:complications / Q000000981:diagnostic imaging*; D009520:New Zealand; D013118:Spinal Cord Diseases / Q000209:etiology / Q000503:physiopathology*; D013904:Thoracic Vertebrae