title: Apolipoprotein E Mimetic Peptide Increases Cerebral Glucose Uptake by Reducing Blood-Brain Barrier Disruption after Controlled Cortical Impact in Mice: An18F-Fluorodeoxyglucose PET/CT Study.
abstract: Traumatic brain injury (TBI) disrupts the blood-brain barrier (BBB) and reduces cerebral glucose uptake. Vascular endothelial growth factor (VEGF) is believed to play a key role in TBI, and COG1410 has demonstrated neuroprotective activity in several models of TBI. However, the effects of COG1410 on VEGF and glucose metabolism following TBI are unknown. The current study aimed to investigate the expression of VEGF and glucose metabolism effects in C57BL/6J male mice subjected to experimental TBI. The results showed that controlled cortical impact (CCI)-induced vestibulomotor deficits were accompanied by increases in brain edema and the expression of VEGF, with a decrease in cerebral glucose uptake. COG1410 treatment significantly improved vestibulomotor deficits and glucose uptake and produced decreases in VEGF in the pericontusion and ipsilateral hemisphere of injury, as well as in brain edema and neuronal degeneration compared with the control group. These data support that COG1410 may have potential as an effective drug therapy for TBI.
authors.affiliation: 1 Department of Neurosurgery, the Affiliated Hospital of Southwest Medical University , Luzhou, China .|2 Department of Neurosurgery, People's Hospital of Deyang City , Deyang, China .
authors.forename: Xinghu
authors.initials: X
authors.lastname: Qin
authors.affiliation: 3 Department of Oncology, People's Hospital of Deyang City , Deyang, China .
authors.forename: Hong
authors.initials: H
authors.lastname: You
authors.affiliation: 4 Department of Cerebrovascular Disease, the Affiliated Hospital of Zunyi Medical College , Zunyi, China .
authors.forename: Fang
authors.initials: F
authors.lastname: Cao
authors.affiliation: 5 Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University , Chongqing, China .
authors.forename: Yue
authors.initials: Y
authors.lastname: Wu
authors.affiliation: 1 Department of Neurosurgery, the Affiliated Hospital of Southwest Medical University , Luzhou, China .
authors.forename: Jianhua
authors.initials: J
authors.lastname: Peng
authors.affiliation: 1 Department of Neurosurgery, the Affiliated Hospital of Southwest Medical University , Luzhou, China .
authors.forename: Jinwei
authors.initials: J
authors.lastname: Pang
authors.affiliation: 2 Department of Neurosurgery, People's Hospital of Deyang City , Deyang, China .
authors.forename: Hong
authors.initials: H
authors.lastname: Xu
authors.affiliation: 1 Department of Neurosurgery, the Affiliated Hospital of Southwest Medical University , Luzhou, China .
authors.forename: Yue
authors.initials: Y
authors.lastname: Chen
authors.affiliation: 1 Department of Neurosurgery, the Affiliated Hospital of Southwest Medical University , Luzhou, China .
authors.forename: Ligang
authors.initials: L
authors.lastname: Chen
authors.affiliation: 6 Department of Medicine (Neurology), Duke University Medical Center , Medicine, Durham, North Carolina.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Vitek
authors.affiliation: 7 Cognosci, Inc., Research Triangle Park , North Carolina.
authors.forename: Fengqiao
authors.initials: F
authors.lastname: Li
authors.affiliation: 5 Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University , Chongqing, China .
authors.forename: Xiaochuan
authors.initials: X
authors.lastname: Sun
authors.affiliation: 1 Department of Neurosurgery, the Affiliated Hospital of Southwest Medical University , Luzhou, China .
authors.forename: Yong
authors.initials: Y
authors.lastname: Jiang
mesh_terms: D000818:Animals; D001057:Apolipoproteins E / Q000008:administration & dosage / Q000494:pharmacology*; D001812:Blood-Brain Barrier / Q000187:drug effects*; D001929:Brain Edema / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D000070642:Brain Injuries, Traumatic / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D004195:Disease Models, Animal; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000072078:Positron Emission Tomography Computed Tomography; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
chemical_list: D001057:Apolipoproteins E; C524548:COG1410; D018696:Neuroprotective Agents; D042461:Vascular Endothelial Growth Factor A; C467480:vascular endothelial growth factor A, mouse; D019788:Fluorodeoxyglucose F18; D005947:Glucose
keywords: COG1410; TBI; VEGF; brain edema; metabolism