title: aEEG monitoring analysis of lesion degree and long-term prognosis in newborns with HIE.
abstract: To conduct monitoring analysis of lesion degree and long-term prognosis using ambulatory electroencephalography (aEEG) in newborns with hypoxic-ischemic encephalopathy (HIE).
  
  
  
  48 cases of newborns with HIE (aged 37 to 41 weeks) as the observation group and another 50 cases of full-term infants with non-traumatic brain illness as the control group were chosen from March 2012 to March 2013. The aEEG were observed, and the continuity and sleep-wake cycle (SWC) between the two groups were compared. The relevance of aEEG monitoring results and HIE, as well as the long-term prognosis, were analyzed.
  
  
  
  33.33% (16/48) of EEG results appeared to be continuous and 20.83% (10/48) of the SWC results were mature for observation group. These EEG and SWC results are conspicuously lower than the control group 100% (50/50) and differences were statistically significant (p<0.05). The maximum voltage of observation group was 56.54±19.33 LV, notably higher than the control group (37.77±2.79 LV). The minimum voltage of the observation group was 4.26±1.25 LV, markedly lower than the control group (7.75±0.67 LV) and these differences were statistically significant (p<0.05). Correlational analysis based on the Spearman approach showed that the monitoring results are positively correlated with clinical classification of HIE. After six months of follow-up, 11 of the 48 cases (22.92%) were found to be disabled (including mental retardation and cerebral palsy).
  
  
  
  aEEG enjoys easy operation, effective diagnosis, supports continuous monitoring and reflects the lesion degree as well as long-term prognosis of newborns with HIE and is, thus, highly recommended in clinical practices.
authors.affiliation: Department of Neonatology, Xuzhou Children's Hospital, Xuzhou, Jiangsu, China. zhenguangli29@163.com.
authors.forename: J-F
authors.initials: JF
authors.lastname: Liu
authors.forename: H-W
authors.initials: HW
authors.lastname: Wu
authors.forename: Z-G
authors.initials: ZG
authors.lastname: Li
authors.forename: G-Z
authors.initials: GZ
authors.lastname: Lu
authors.forename: X
authors.initials: X
authors.lastname: Yang
mesh_terms: D001921:Brain / Q000503:physiopathology; D004569:Electroencephalography; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000175:diagnosis* / Q000503:physiopathology; D007231:Infant, Newborn; D011379:Prognosis