title: Obstructive Uropathy as an Initial Presentation of Primary Myelofibrosis: Case Report and Review of Literature.
abstract: Primary myelofibrosis (PMF) is a rare hematological disorder associated with progressive cytopenia and extra-medullary hematopoiesis. Acute kidney injury in this disease has been reported from diverse etiologies such as renal and peri-renal extramedullary hematopoiesis and tumor lysis syndrome. We report a patient who presented with obstructive uropathy from uric acid stones who was incidentally diagnosed with PMF during workup for persistent thrombocytosis and leukocytosis. Marrow histopathology was unique in presenting features of early PMF despite clinical picture mimicking essential thrombocythemia. Despite a common background of hyperuricemia in myeloproliferative neoplasms, AKI resulting from urate nephrolithiasis has seldom been reported in PMF. Published data on this association and clinical management is reviewed briefly.
authors.affiliation: Washington Hospital Center, Georgetown University, 110 Irving Street, NW, Suite 2A70, Washington, DC 20010 USA.
authors.forename: Anirban
authors.initials: A
authors.lastname: Ganguli
authors.affiliation: Department of Urology, Warrington and Halton NHS Foundation Trust, Warrington, UK.
authors.forename: Ramandeep Singh
authors.initials: RS
authors.lastname: Chalokia
authors.affiliation: Department of Pathology, INSCOL Hospital, Chandigarh, India.
authors.forename: Brahm Jyot
authors.initials: BJ
authors.lastname: Kaur
keywords: Acute kidney injury; Obstructive uropathy; Primary myelofibrosis; Renal calculi