title: Recent Advances in Bone Marrow Transplantation from Unrelated Volunteer Donors.
abstract: Marrow transplantation from a phenotypically identical unrelated donor has become a feasible and curative form of treatment for patients with several malignant and nonmalignant disorders who lack an HLA-matched sibling donor. Given the rapid growth of registries of HLA-typed volunteers(-including over 2 million people-)it is now possible to identify a suitable unrelated marrow donor for up to 50% of patients. In this review the recent acquisitions regarding the structure of HLA complex, the new molecular typing technologies and clinical results obtained with unrelated marrow transplants, will be considered.
authors.affiliation: a Department of Pediatrics , University of Turin.
authors.forename: A
authors.initials: A
authors.lastname: Busca
authors.affiliation: a Department of Pediatrics , University of Turin.|b Department of Genetics , University of Turin.
authors.forename: A
authors.initials: A
authors.lastname: Amoroso
authors.affiliation: a Department of Pediatrics , University of Turin.
authors.forename: R
authors.initials: R
authors.lastname: Miniero
keywords: Bone Marrow Transplantation; Graft-Versus-Host Disease; HLA System