title: Ultra-High Resolution Optical Coherence Tomography Imaging of Unilateral Drusen in a 31 Year Old Woman.
abstract: We report a case of widespread unilateral drusen in a healthy 31 year old Caucasian woman using multi-modal imaging including ultra-high resolution optical coherence tomography (UHR-OCT). Dilated fundus exam showed multiple drusen-like lesions in the posterior pole without heme or fluid. Fundus auto fluorescence demonstrated hyperautofluorescent at the deposits. Fluorescein angiography revealed mild hyperfluorescence and staining of the lesions. Spectral-domain optical coherence tomography (SD-OCT) OS showed accumulations in the temporal macula at Bruch's membrane. UHR-OCT provided improved axial resolution compared to the standard 5 μm on the commercial SD-OCT and confirmed the presence of deposits in Bruch's membrane, consistent with drusen. The retinal layers were draped over the excrescences but did not show any disruption.
authors.affiliation: New England Eye Center and Tufts Medical Center, Tufts University, Boston, MA, USA; Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, USA.
authors.forename: Talisa E
authors.initials: TE
authors.lastname: de Carlo
authors.affiliation: New England Eye Center and Tufts Medical Center, Tufts University, Boston, MA, USA; Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, USA.
authors.forename: Mehreen
authors.initials: M
authors.lastname: Adhi
authors.affiliation: Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, USA.
authors.forename: Chen D
authors.initials: CD
authors.lastname: Lu
authors.affiliation: New England Eye Center and Tufts Medical Center, Tufts University, Boston, MA, USA.
authors.forename: Jay S
authors.initials: JS
authors.lastname: Duker
authors.affiliation: Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, USA.
authors.forename: James G
authors.initials: JG
authors.lastname: Fujimoto
authors.affiliation: New England Eye Center and Tufts Medical Center, Tufts University, Boston, MA, USA.
authors.forename: Nadia K
authors.initials: NK
authors.lastname: Waheed
keywords: Drusen; Optical Coherence Tomography; Retina; Retinal Imaging