title: Interleaved neuromuscular electrical stimulation: Motor unit recruitment overlap.
abstract: In this study, we quantified the "overlap" between motor units recruited by single pulses of neuromuscular electrical stimulation (NMES) delivered over the tibialis anterior muscle (mNMES) and the common peroneal nerve (nNMES). We then quantified the torque produced when pulses were alternated between the mNMES and nNMES sites at 40 Hz ("interleaved" NMES; iNMES).
  
  
  
  Overlap was assessed by comparing torque produced by twitches evoked by mNMES, nNMES, and both delivered together, over a range of stimulus intensities. Trains of iNMES were delivered at the intensity that produced the lowest overlap.
  
  
  
  Overlap was lowest (5%) when twitches evoked by both mNMES and nNMES produced 10% peak twitch torque. iNMES delivered at this intensity generated 25% of maximal voluntary dorsiflexion torque (11 Nm).
  
  
  
  Low intensity iNMES leads to low overlap and produces torque that is functionally relevant to evoke dorsiflexion during walking. Muscle Nerve 55: 490-499, 2017.
authors.affiliation: Laboratory of Neurophysiology, Faculty of Physical Education and Recreation, 4-218 Van Vliet Complex, University of Alberta, Edmonton, Canada, T6G 2H9.
authors.forename: Matheus J
authors.initials: MJ
authors.lastname: Wiest
authors.affiliation: Rehabilitation Engineering Laboratory, Toronto Rehabilitation Institute, University Health Network, Toronto, Canada.
authors.forename: Austin J
authors.initials: AJ
authors.lastname: Bergquist
authors.affiliation: Laboratory of Neurophysiology, Faculty of Physical Education and Recreation, 4-218 Van Vliet Complex, University of Alberta, Edmonton, Canada, T6G 2H9.|Applied Neuromechanics Research Group, Neuromechanics Laboratory, Universidade Federal do Pampa, Uruguaiana, Brazil.
authors.forename: Helen L
authors.initials: HL
authors.lastname: Schimidt
authors.affiliation: Laboratory of Neurophysiology, Faculty of Physical Education and Recreation, 4-218 Van Vliet Complex, University of Alberta, Edmonton, Canada, T6G 2H9.
authors.forename: Kelvin E
authors.initials: KE
authors.lastname: Jones
authors.affiliation: Laboratory of Neurophysiology, Faculty of Physical Education and Recreation, 4-218 Van Vliet Complex, University of Alberta, Edmonton, Canada, T6G 2H9.
authors.forename: David F
authors.initials: DF
authors.lastname: Collins
mesh_terms: D000328:Adult; D004558:Electric Stimulation; D004576:Electromyography; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D009119:Muscle Contraction / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology; D009469:Neuromuscular Junction / Q000502:physiology*; D011999:Recruitment, Neurophysiological / Q000502:physiology*; D019415:Torque; D016138:Walking / Q000502:physiology; D055815:Young Adult
keywords: NMES; interleaved; motor unit; neuromuscular electrical stimulation; recruitment overlap; twitch torque