title: Hepatitis B carrier state among SLE patients: case-control study.
abstract: The association between hepatitis B and autoimmune disorders has been intriguing for decades. Many reports have speculated on the possible linkage between these two conditions, yet never before data driven from a large national database was utilized in order to investigate this issue. The objective of this study was to investigate the association between SLE and hepatitis B carrier state. Patients with SLE were compared with age- and sex-matched controls regarding the proportion of hepatitis B carrier state in a case-control study. Chi-square and t tests were used for univariate analysis, and a logistic regression model was used for multivariate analysis. The study was performed utilizing the medical database of Clalit Health Services. The study included 5018 lupus patients over the age of 20 years and 25,090 age- and sex-frequency-matched controls without SLE. The proportion of hepatitis B carriers was higher in SLE patients as compared to controls (0.9 and 0.56 %, respectively; p < 0.001). A significant association was also observed among patients in lower socioeconomic status. In a multivariate logistic regression analysis, SLE was significantly associated with hepatitis B (OR = 1.828, 95 % CI = 1.291-2.590). Patients with SLE have a greater proportion of hepatitis B carrier state than matched controls.
authors.affiliation: Department of Medicine 'B', Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, 5262100, Tel-Hashomer, Israel.|Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv-Yafo, Israel.
authors.forename: Omer
authors.initials: O
authors.lastname: Gendelman
authors.affiliation: Department of Medicine 'B', Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, 5262100, Tel-Hashomer, Israel.|Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv-Yafo, Israel.
authors.forename: Naim
authors.initials: N
authors.lastname: Mahroum
authors.affiliation: Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.
authors.forename: Doron
authors.initials: D
authors.lastname: Comaneshter
authors.affiliation: Metabolic Bone Disease Service, Meir Medical Center, Kfar-Saba, Israel.
authors.forename: Pnina
authors.initials: P
authors.lastname: Rotman-Pikielny
authors.affiliation: Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.|Chief Physician's Office, Clalit Health Services, Tel Aviv, Israel.
authors.forename: Arnon D
authors.initials: AD
authors.lastname: Cohen
authors.affiliation: Department of Medicine 'B', Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, 5262100, Tel-Hashomer, Israel. howard.amital@sheba.health.gov.il.|Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv-Yafo, Israel. howard.amital@sheba.health.gov.il.
authors.forename: Howard
authors.initials: H
authors.lastname: Amital
authors.affiliation: Central Management, Clalit Health Services, Tel Aviv, Israel.|Department of Public Health, Faculty of Health Sciences, Ben-Gurion University of Negev, Beer Sheva, Israel.
authors.forename: Michael
authors.initials: M
authors.lastname: Sherf
mesh_terms: D000328:Adult; D000368:Aged; D002353:Carrier State; D016022:Case-Control Studies; D005260:Female; D006509:Hepatitis B / Q000453:epidemiology*; D006515:Hepatitis B virus; D006801:Humans; D007557:Israel / Q000453:epidemiology; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio
keywords: Autoimmune disease; Carrier; Hepatitis B; Infections; SLE