title: (1)H-MRS asymmetry changes in the anterior and posterior cingulate gyrus in patients with mild cognitive impairment and mild Alzheimer's disease.
abstract: Alzheimer's disease (AD) is the most common cause of dementia worldwide. Amnestic mild cognitive impairment (aMCI) is often the prodromal stage to AD. Most patients with aMCI harbor the pathologic changes of AD and demonstrate transition to AD at a rate of 10%-15% per year. Patients with AD and aMCI experience progressive brain metabolite changes. Accumulating evidence indicates that the asymmetry changes of left and right brain happen in the early stage of AD. However, the features of asymmetry changes in both anterior cingulate gyrus (ACG) and posterior cingulate gyrus (PCG) are still unclear. Here, we examine the left-right asymmetry changes of metabolites in ACG and PCG. Fifteen cases of mild AD patients meeting criteria for probable AD of NINDS-ADRDA, thirteen cases of aMCI according to the Mayo Clinic Alzheimer's Disease Research Center criteria, and sixteen cases of age-matched normal controls (NC) received Proton magnetic resonance spectroscopy ((1)H-MRS) for measurement of NAA/mI, NAA/Cr, Cho/Cr, and mI/Cr ratios in the PCG and ACG bilaterally. We analyzed (1)H-MRS data by paired t-test to validate the left-right asymmetry of (1)H-MRS data in the PCG and ACG. In AD, there was a significant difference in mI/Cr between the left and right ACG (P<0.001) and the left and right PCG (P=0.007). In aMCI, there was a significant difference in mI/Cr between the left and right ACG (P<0.001). In NC, there were no differences in the ratio value of metabolites NAA/mI, NAA/Cr, Cho/Cr, and mI/Cr between the left and right ACG and PCG. Thus, the left-right asymmetry of mI/Cr in the ACG and PCG may be an important biological indicator of mild AD.
authors.affiliation: Tongde Hospital of Zhejiang Provence & Zhejiang Mental Health Center, Hangzhou, Zhejiang 310012, China.
authors.forename: Zhongwei
authors.initials: Z
authors.lastname: Guo
authors.affiliation: China-USA Neuroimaging Research Institute & Department of Radiology, the Second Affiliated Hospital,Wenzhou Medical University, Wenzhou 325027, China; Center for Cognition and Brain Disorders & Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou Normal University, Hangzhou, Zhejiang 310015, China.
authors.forename: Xiaozheng
authors.initials: X
authors.lastname: Liu
authors.affiliation: Tongde Hospital of Zhejiang Provence & Zhejiang Mental Health Center, Hangzhou, Zhejiang 310012, China.
authors.forename: Hongtao
authors.initials: H
authors.lastname: Hou
authors.affiliation: Tongde Hospital of Zhejiang Provence & Zhejiang Mental Health Center, Hangzhou, Zhejiang 310012, China.
authors.forename: Fuquan
authors.initials: F
authors.lastname: Wei
authors.affiliation: Tongde Hospital of Zhejiang Provence & Zhejiang Mental Health Center, Hangzhou, Zhejiang 310012, China.
authors.forename: Xingli
authors.initials: X
authors.lastname: Chen
authors.affiliation: The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang 310015, China.
authors.forename: Yuedi
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, and the Collaborative Innovation Center for Brain Science, Hangzhou, Zhejiang 310016, China; Key Laboratory of Medical Neurobiology of Chinese Ministry of Health, Hangzhou, Zhejiang 310058, China. Electronic address: srrcw@zju.edu.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000473:pathology*; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D002794:Choline / Q000378:metabolism; D060825:Cognitive Dysfunction / Q000175:diagnosis* / Q000473:pathology*; D003401:Creatine / Q000378:metabolism; D004292:Dominance, Cerebral / Q000502:physiology*; D005260:Female; D006179:Gyrus Cinguli / Q000473:pathology*; D006801:Humans; D007294:Inositol / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D066244:Proton Magnetic Resonance Spectroscopy
chemical_list: D001224:Aspartic Acid; D007294:Inositol; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline