title: Reduced marker of vascularization in the anterior hippocampus in a female monkey model of depression.
abstract: Depression is a common and debilitating mood disorder that impacts women more often than men. The mechanisms that result in depressive behaviors are not fully understood; however, the hippocampus has been noted as a key structure in the pathophysiology of depression. In addition to neural implications of depression, the cardiovascular system is impacted. Although not as commonly considered, the cerebrovasculature is critical to brain function, impacted by environmental stimuli, and is capable of altering neural function and thereby behavior. In the current study, we assessed the relationship between depressive behavior and a marker of vascularization of the hippocampus in adult female cynomolgus macaques (Macaca fascicularis). Similar to previously noted impacts on neuropil and glia, the depressed phenotype predicts a reduction in a marker of vascular length in the anterior hippocampus. These data reinforce the growing recognition of the effects of depression on vasculature and support further consideration of vascular endpoints in studies aimed at the elucidation of the mechanisms underlying depression.
authors.affiliation: Department of Biology, Emory College, Atlanta, GA, USA.
authors.forename: Anisha
authors.initials: A
authors.lastname: Kalidindi
authors.affiliation: Department of Physiology, Emory University, Atlanta, GA, USA.
authors.forename: Sean D
authors.initials: SD
authors.lastname: Kelly
authors.affiliation: Neuroscience and Behavioral Biology, Agnes Scott College, Decatur, GA, USA.
authors.forename: Kaela S
authors.initials: KS
authors.lastname: Singleton
authors.affiliation: Department of Psychiatry & Behavioral Science, Emory University, Atlanta, GA, USA.
authors.forename: Dora
authors.initials: D
authors.lastname: Guzman
authors.affiliation: Department of Physiology, Emory University, Atlanta, GA, USA.
authors.forename: Liana
authors.initials: L
authors.lastname: Merrill
authors.affiliation: Department of Pathology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
authors.forename: Stephanie L
authors.initials: SL
authors.lastname: Willard
authors.affiliation: Department of Pathology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
authors.forename: Carol A
authors.initials: CA
authors.lastname: Shively
authors.affiliation: Department of Physiology, Emory University, Atlanta, GA, USA; Department of Psychiatry & Behavioral Science, Emory University, Atlanta, GA, USA. Electronic address: gretchen.mccandless@vcuhealth.org.
authors.forename: Gretchen N
authors.initials: GN
authors.lastname: Neigh
mesh_terms: D000818:Animals; D003863:Depression / Q000473:pathology*; D004195:Disease Models, Animal; D005260:Female; D051272:Glucose Transporter Type 1 / Q000378:metabolism; D006624:Hippocampus / Q000098:blood supply*; D007150:Immunohistochemistry; D008252:Macaca fascicularis
chemical_list: D051272:Glucose Transporter Type 1
keywords: Cerebrovasculature; Depression; Female; Hippocampus; Macaca fascicularis; Unbiased stereology; Vascular