title: MafB deficiency accelerates the development of obesity in mice.
abstract: MafB, a transcription factor expressed selectively in macrophages, has important roles in some macrophage-related diseases, especially in atherosclerosis. In this study, we investigated the mechanism by which hematopoietic-specific MafB deficiency induces the development of obesity. Wild-type and hematopoietic cell-specific Mafb-deficient mice were fed a high-fat diet for 10 weeks. The Mafb-deficient mice exhibited higher body weights and faster rates of body weight increase than control mice. The Mafb-deficient mice also had a higher percentage of body fat than the wild-type mice, due to increased adipocyte size and serum cholesterol levels. Reverse transcription-PCR analysis showed a reduction in apoptosis inhibitor of macrophage (AIM) in Mafb-deficient adipose tissue. AIM is known as an inhibitor of lipogenesis in adipocytes and is expressed in adipose tissue macrophages. Collectively, our data suggest that Mafb deficiency in hematopoietic cells accelerates the development of obesity.
authors.affiliation: Department of Anatomy and Embryology Faculty of Medicine University of Tsukuba Ibaraki Japan.
authors.forename: Mai Thi Nhu
authors.initials: MT
authors.lastname: Tran
authors.affiliation: Department of Anatomy and Embryology Faculty of Medicine University of Tsukuba Ibaraki Japan; Laboratory Animal Resource Center Faculty of Medicine University of Tsukuba Ibaraki Japan; International Institute for Integrative Sleep Medicine (WPI-IIIS) University of Tsukuba Ibaraki Japan.
authors.forename: Michito
authors.initials: M
authors.lastname: Hamada
authors.affiliation: Department of Anatomy and Embryology Faculty of Medicine University of Tsukuba Ibaraki Japan.
authors.forename: Megumi
authors.initials: M
authors.lastname: Nakamura
authors.affiliation: Department of Anatomy and Embryology Faculty of Medicine University of Tsukuba Ibaraki Japan.
authors.forename: Hyojung
authors.initials: H
authors.lastname: Jeon
authors.affiliation: Department of Anatomy and Embryology Faculty of Medicine University of Tsukuba Ibaraki Japan.
authors.forename: Risa
authors.initials: R
authors.lastname: Kamei
authors.affiliation: Department of Anatomy and Embryology Faculty of Medicine University of Tsukuba Ibaraki Japan; Ph.D. Program in Human Biology School of Integrative and Global Majors University of Tsukuba Ibaraki Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Tsunakawa
authors.affiliation: Department of Anatomy and Embryology Faculty of Medicine University of Tsukuba Ibaraki Japan; Ph.D. Program in Human Biology School of Integrative and Global Majors University of Tsukuba Ibaraki Japan.
authors.forename: Kaushalya
authors.initials: K
authors.lastname: Kulathunga
authors.affiliation: Laboratory of Molecular Biology Department of Animal Science and Technology National Taiwan University Taipei Taiwan.
authors.forename: Yuan-Yu
authors.initials: YY
authors.lastname: Lin
authors.affiliation: Department of Anatomy and Embryology Faculty of Medicine University of Tsukuba Ibaraki Japan.
authors.forename: Kumiko
authors.initials: K
authors.lastname: Fujisawa
authors.affiliation: Department of Anatomy and Embryology Faculty of Medicine University of Tsukuba Ibaraki Japan; Laboratory Animal Resource Center Faculty of Medicine University of Tsukuba Ibaraki Japan; International Institute for Integrative Sleep Medicine (WPI-IIIS) University of Tsukuba Ibaraki Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kudo
authors.affiliation: Department of Anatomy and Embryology Faculty of Medicine University of Tsukuba Ibaraki Japan; Laboratory Animal Resource Center Faculty of Medicine University of Tsukuba Ibaraki Japan; International Institute for Integrative Sleep Medicine (WPI-IIIS) University of Tsukuba Ibaraki Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Takahashi
keywords: MafB; adipose tissue macrophages; apoptosis inhibitor of macrophage; obesity