title: [Clinical analysis of 39 cases who received transplantation of kidney from pediatric organ donors].
abstract: OBJECTIVE
  To explore the feasibility and clinical significance of pediatric renal transplantation using organ donations from pediatric patients donors.
  
  
  METHODS
  Clinical data of children who underwent renal transplantation using organ donations from pediatric patients between September 2011 and December 2014 were retrospectively analyzed, including diagnosis and treatment before transplant, transplant operation, immunosuppression, complication and prognosis.
  
  
  RESULTS
  Totally 39 cases received pediatric organ donation-pediatric kidney transplantation. The median age at transplantation was 10.5 years. Before transplantation, 37 cases received chronic dialysis. The median waiting time for transplantation was 15 months. The 39 cases received kidneys from 29 donors who were aged from 9 days to 7 years (median 13 months). The median duration of follow-up after the transplantation was 19 months. At 3 month after transplantation and latest follow-up, the length of graft increased (11.3±6.4) mm and (17.5±10.8) mm, respectively. At 6 month and 12 month after transplantation, the height of the recipients increased (5.8±3.5) cm and (15.0±3.5) cm, respectively. At latest follow-up, the serum creatinine level was (80.3±31.9) μmol/L and the eGFR was (94.4±32.9) ml/(min·1.73 m(2)). The recipient survival rate was 100% and grafts survived in 34 cases; 3 cases lost graft function due to thrombosis of renal vessels and the other 2 cases due to bleeding and chronic allograft nephropathy. Donor age of less than 12 months carried higher risk of thrombosis/hemorrhagic complication (P=0.042) and graft dysfunction (P=0.017).
  
  
  CONCLUSIONS
  Favorable outcome can be obtained from pediatric organ donation-pediatric kidney transplantation. Patient survival rate reached 100% at one-year and three-year graft survival rate was 87%. The size of the allograft would increase and the height of the recipients would improve after transplantation.
authors.affiliation: Department of Nephrology and Rheumatology, Children's Hospital of Fudan University, Shanghai 201102, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Shen
authors.forename: H
authors.initials: H
authors.lastname: Xu
authors.forename: X Y
authors.initials: XY
authors.lastname: Fang
authors.forename: H M
authors.initials: HM
authors.lastname: Liu
authors.forename: Y H
authors.initials: YH
authors.lastname: Zhai
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: Y H
authors.initials: YH
authors.lastname: Zhu
authors.forename: L
authors.initials: L
authors.lastname: Zeng
authors.forename: L
authors.initials: L
authors.lastname: Zhang
mesh_terms: D002648:Child; D006085:Graft Survival; D006801:Humans; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D014019:Tissue Donors; D014184:Transplantation, Homologous