title: Significance of adjusting salt intake by body weight in the evaluation of dietary salt and blood pressure.
abstract: The close association between dietary salt and hypertension is well established. However, previous studies generally assessed salt intake without adjustment for body weight. Herein, we investigated the significance of body weight-adjusted salt intake in the general population. The present cross-sectional study included 7629 participants from our yearly physical checkup program, and their salt intake was assessed using a spot urine test to estimate 24-hour urinary salt excretion. Total salt intake increased with increasing body weight. Body weight-adjusted salt intake was greater in participants with hypertension than in those without hypertension. Systolic blood pressure, estimated glomerular filtration rate, and urinary albumin were independently correlated with body weight-adjusted salt intake after adjustment for possible cardiovascular risk factors. Excessive body weight-adjusted salt intake could be related to an increase in blood pressure and hypertensive organ damage. Adjustment for body weight might therefore provide clinically important information when assessing individual salt intake.
authors.affiliation: Department of Internal Medicine, Enshu Hospital, Hamamatsu, Japan.
authors.forename: Tomomi
authors.initials: T
authors.lastname: Hashimoto
authors.affiliation: Department of Internal Medicine, Enshu Hospital, Hamamatsu, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takase
authors.affiliation: Department of Internal Medicine, Enshu Hospital, Hamamatsu, Japan.
authors.forename: Tateo
authors.initials: T
authors.lastname: Okado
authors.affiliation: Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan. Electronic address: tomosugi@med.nagoya-cu.ac.jp.
authors.forename: Tomonori
authors.initials: T
authors.lastname: Sugiura
authors.affiliation: Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors.forename: Sumiyo
authors.initials: S
authors.lastname: Yamashita
authors.affiliation: Asahi Rosai Hospital, Owariasahi, Japan.
authors.forename: Genjiro
authors.initials: G
authors.lastname: Kimura
authors.affiliation: Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Ohte
authors.affiliation: Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Dohi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D001835:Body Weight; D002318:Cardiovascular Diseases / Q000453:epidemiology; D003430:Cross-Sectional Studies; D004562:Electrocardiography; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D017673:Sodium Chloride, Dietary / Q000008:administration & dosage / Q000009:adverse effects* / Q000652:urine; D018709:Statistics, Nonparametric
chemical_list: D017673:Sodium Chloride, Dietary
keywords: Glomerular filtration rate; organ damage; sodium; urinary albumin