title: Vancomycin-Functionalized Gold and Silver Nanoparticles as an Antibacterial Nanoplatform Against Methicillin-Resistant Staphylococcus aureus.
abstract: The functionalization of metallic nanoparticles using antibiotics is a promising nanoplatform to combat bacterial resistance. In the current report, vancomycin was used to functionalize gold nanoparticles (Van-AuNPs) and silver nanoparticles (Van-AgNPs) through a one-step, one-pot process. The process is facile and employs a green synthetic route. Vancomycin was used as a reducing agent to generate Van-AuNPs and Van-AgNPs from gold and silver ions, respectively. Surface plasmon resonance was observed at 520 nm for Van-AuNPs and at 405 nm for Van-AgNPs. Both Van-AuNPs and Van-AgNPs were spherically shaped, with average diameters of 11.01 ± 3.62 nm and 12.08 ± 2.13 nm, respectively. Strong diffraction peaks in the X-ray diffraction profiles of both nanoparticles confirmed their face-centered cubic structures. The Van-AgNPs presented higher in vitro antibacterial activity (2.4-4.8-fold increase) than Van-AuNPs against methicillin-resistant Staphylococcus aureus (MRSA). These results suggest that AgNPs provide a more effective anti-MRA nanoplatform than AuNPs for vancomvcin functionalization.
authors.forename: Ye Eun
authors.initials: YE
authors.lastname: Hur
authors.forename: Youmie
authors.initials: Y
authors.lastname: Park
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D012834:Silver / Q000737:chemistry*; D014640:Vancomycin / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D012834:Silver; D014640:Vancomycin; D006046:Gold