title: Zika virus infections.
abstract: Since its discovery in 1947 in Uganda, the Zika virus (ZIKV) remained in the shadows emerging in 2007 in Micronesia, where hundreds of dengue-like syndromes were reported. Then, in 2013-2014, it was rife in French Polynesia, where the first neurological effects were observed. More recently, its arrival in Brazil was accompanied by an unusually high number of children with microcephaly born to mothers infected with ZIKV during the first trimester of pregnancy. In 2016, the World Health Organization declared ZIKV infection to be a public health emergency and now talks about a ZIKV pandemic. This review aims to summarize the current knowledge about ZIKV infection, successively addressing its transmission, epidemiology, clinical aspects, diagnosis, treatment, and prevention before discussing some perspectives.
authors.affiliation: Centre d'épidémiologie et de santé publique des Armées, Camp militaire de Sainte-Marthe, BP 40026, 13568 Marseille cedex 02, France, Direction interarmées du service de santé en Guyane, Quartier La Madeleine, BP 6019, 97306 Cayenne cedex, Guyane française.
authors.forename: F
authors.initials: F
authors.lastname: de Laval
authors.affiliation: Institut de recherche biomédicale des Armées, Centre national de référence des arbovirus, Hôpital d'instruction des Armées Laveran, 34, boulevard Laveran 13013 Marseille, France.
authors.forename: I
authors.initials: I
authors.lastname: Leparc-Goffart
authors.affiliation: Centre d'épidémiologie et de santé publique des Armées, Camp militaire de Sainte-Marthe, BP 40026, 13568 Marseille cedex 02, France.
authors.forename: J-B
authors.initials: JB
authors.lastname: Meynard
authors.affiliation: Service de pathologie infectieuse et tropicale, Hôpital d'instruction des Armées Laveran, 34, boulevard Laveran 13013 Marseille, France.
authors.forename: H
authors.initials: H
authors.lastname: Daubigny
authors.affiliation: Service de pathologie infectieuse et tropicale, Hôpital d'instruction des Armées Laveran, 34, boulevard Laveran 13013 Marseille, France.
authors.forename: F
authors.initials: F
authors.lastname: Simon
authors.affiliation: Direction interarmées du service de santé en Guyane, Quartier La Madeleine, BP 6019, 97306 Cayenne cedex, Guyane française, Institut Pasteur de la Guyane, Unité d'entomologie médicale, 23, avenue Pasteur, BP 6010, 97306 Cayenne cedex, Guyane française, Unité de recherche en maladies infectieuses et tropicales émergentes, UM 63, CNRS 7278, IRD 198, and Inserm 1095, Faculté de médecine La Timone, Aix-Marseille Université, 27, boulevard Jean-Moulin, Marseille, 13385, France, Institut de recherche biomédicale des Armées, Unité de parasitologie et d'entomologie médicale, Hôpital d'instruction des Armées Laveran, 34, boulevard Laveran 13013 Marseille, France.
authors.forename: S
authors.initials: S
authors.lastname: Briolant
mesh_terms: D005260:Female; D006801:Humans; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology; D000071243:Zika Virus Infection / Q000151:congenital / Q000175:diagnosis / Q000628:therapy
keywords: Arbovirus; Exanthema; Flavivirus; Zika; Zika fever; microcephaly