title: Sex, Race, and Age Disparities in the Improvement of Survival for Gastrointestinal Cancer over Time.
abstract: There have been notable improvements in survival over the past 2 decades for gastrointestinal (GI) cancer. However, the degree of improvement by age, race, and sex remains unclear. We analyzed data from 9 population-based cancer registries included in the SEER program of the National Cancer Institute (SEER 9) in 1990 to 2009 (n = 288,337). The degree of survival improvement over time by age, race, and sex was longitudinally measured. From 1990 to 2009, improvements in survival were greater for younger age groups. For patients aged 20 to 49 years and diagnosed from 2005 to 2009, adjusted HRs (95% CIs) were 0.74 (95% CI, 0.66-0.83), 0.49 (95% CI, 0.37-0.64), 0.69 (95% CI, 0.65-0.76), 0.62 (95% CI, 0.54-0.69), and 0.56 (95% CI, 0.42-0.76), for cancer of the stomach, small intestine, colon, rectum and anus, respectively, compared with the same age groups of patients diagnosed during 1990 to 1994. Compared with African Americans, whites experienced greater improvement in small intestinal and anal cancer survival. Female anal cancer and regional anal cancer patients experienced no improvement. Our data suggest that different improvement in survival in age, sex and race exists.
authors.affiliation: Department of Radiation Oncology, Fudan University Shanghai Cancer, Center, China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Jue-Feng
authors.initials: JF
authors.lastname: Wan
authors.affiliation: Department of Radiation Oncology, Fudan University Shanghai Cancer, Center, China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Li-Feng
authors.initials: LF
authors.lastname: Yang
authors.affiliation: School of Medicine, Nanjing University, Nanjing, jiangsu, 210093, China.|Department of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, jiangsu, 210006, China.
authors.forename: Yun-Zhu
authors.initials: YZ
authors.lastname: Shen
authors.affiliation: Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.|Department of Clinical Statistical Center, Fudan University Shanghai Cancer, Center, China.
authors.forename: Hui-Xun
authors.initials: HX
authors.lastname: Jia
authors.affiliation: Department of Radiation Oncology, Fudan University Shanghai Cancer, Center, China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Ji
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Department of Radiation Oncology, Fudan University Shanghai Cancer, Center, China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Gui-Chao
authors.initials: GC
authors.lastname: Li
authors.affiliation: Department of Radiation Oncology, Fudan University Shanghai Cancer, Center, China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000367:Age Factors; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000401:mortality*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D054547:National Cancer Institute (U.S.); D044469:Racial Groups; D012189:Retrospective Studies; D018426:SEER Program; D014481:United States; D055815:Young Adult