title: [ZNF143 is involved in CTCF-mediated chromatin interactions by cooperation with cohesin and other partners].
abstract: ZNF143 is a ubiquitously expressed transcription factor conserved in vertebrates and might regulate the expression of numerous genes. But its function in mediating chromatin interactions remains elusive. By integrated analysis of public datasets, we provided evidence that a majority of ZNF143 binding sites (BSs) were involved in CTCF-mediated chromatin interaction networks (CTCF-CINs) by overlapping with cohesin-BSs and CTCF-BSs. We further showed that only a very few CTCF-CINs were associated with ZNF143 alone, whereas those associated with ZNF143 and cohesin simultaneously were highly overlapped with constitutive, conserved CTCF-BSs and enriched at boundaries of chromatin topologically associating domains. These observations implicate that as an important partner of CTCF, ZNF143 helps it establish the conserved chromatin structure by cooperating with cohesin.
authors.affiliation: College of Life Sciences, Capital Normal University, 105 Xisanhuanbei Road, Haidian District, Beijing, 100048, China.|Beijing Institute of Biotechnology, No. 20, Dongdajie Street, Fengtai District, Beijing, 100071, P. R. China.
authors.forename: B-Y
authors.initials: BY
authors.lastname: Ye
authors.affiliation: Beijing Institute of Biotechnology, No. 20, Dongdajie Street, Fengtai District, Beijing, 100071, P. R. China.
authors.forename: W-L
authors.initials: WL
authors.lastname: Shen
authors.affiliation: Beijing Institute of Biotechnology, No. 20, Dongdajie Street, Fengtai District, Beijing, 100071, P. R. China.
authors.forename: D
authors.initials: D
authors.lastname: Wang
authors.affiliation: Beijing Institute of Biotechnology, No. 20, Dongdajie Street, Fengtai District, Beijing, 100071, P. R. China.
authors.forename: P
authors.initials: P
authors.lastname: Li
authors.affiliation: Beijing Institute of Biotechnology, No. 20, Dongdajie Street, Fengtai District, Beijing, 100071, P. R. China.
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Beijing Institute of Biotechnology, No. 20, Dongdajie Street, Fengtai District, Beijing, 100071, P. R. China.
authors.forename: M-L
authors.initials: ML
authors.lastname: Shi
authors.affiliation: Beijing Institute of Biotechnology, No. 20, Dongdajie Street, Fengtai District, Beijing, 100071, P. R. China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: College of Life Sciences, Capital Normal University, 105 Xisanhuanbei Road, Haidian District, Beijing, 100048, China.|fxzhang@hotmail.com.
authors.forename: F-X
authors.initials: FX
authors.lastname: Zhang
authors.affiliation: Beijing Institute of Biotechnology, No. 20, Dongdajie Street, Fengtai District, Beijing, 100071, P. R. China.|zhaozh@nic.bmi.ac.cn.
authors.forename: Z-H
authors.initials: ZH
authors.lastname: Zhao
mesh_terms: D001665:Binding Sites; D000076246:CCCTC-Binding Factor; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism*; D002843:Chromatin / Q000737:chemistry* / Q000378:metabolism; D042002:Chromatin Assembly and Disassembly; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics / Q000378:metabolism*; D030541:Databases, Genetic; D015870:Gene Expression; D006801:Humans; D020014:K562 Cells; D059372:Nucleotide Motifs; D011485:Protein Binding; D025941:Protein Interaction Mapping; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism*; D000097722:Cohesins
chemical_list: D000076246:CCCTC-Binding Factor; D018797:Cell Cycle Proteins; D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D012097:Repressor Proteins; D015534:Trans-Activators; D000097722:Cohesins; C000619697:CTCF protein, human; C114253:ZNF143 protein, human
keywords: CTCF; ZNF143; chromatin interactions; cohesin