title: Key donor factors associated with graft loss among liver transplant recipients with human immunodeficiency virus.
abstract: Human immunodeficiency virus (HIV)-infected liver transplant (LT) recipients have higher risk of graft loss than HIV-uninfected recipients. As the original donor risk index excluded HIV-positive patients, donor factors associated with graft loss in HIV-positive recipients are unknown.
  
  
  
  Identifying all HIV-positive patients in the Scientific Registry of Transplant Recipients, supplemented by all HIV-infected patients in the solid organ transplantation in HIV: Multi-Site Study (HIV-TR), we evaluated donor factors associated with graft loss among HIV-positive recipients transplanted between March 2002 and August 2012.
  
  
  
  A total of 249 HIV-positive LT recipients were followed for median 2.4 (interquartile range [IQR]: 0.8-4.9) years. In univariate analysis, donor diabetes (HR=2.09; P=.002) and donor hypertension (HR=1.43; P=.048) were significantly associated with graft loss, and African-American (AA) recipient:non-AA donor race mismatch (HR=1.60; P=.07), other cause of donor death compared to trauma (HR=2.02; P=.09), and donor age 30 years or older (HR=1.53; P=.05) were of borderline significance. In multivariate analysis, donor diabetes (HR=2.12; 95% CI: 1.33-3.38; P=.002) was the only significant predictor of graft loss.
  
  
  
  In HIV-positive LT recipients, risk of graft loss is strongly influenced by donor diabetes. This information may be useful to transplant physicians seeking to optimize overall graft survival in their HIV-positive LT recipients.
authors.affiliation: Universidade de Santiago de Compostela (CLINURSID), Santiago de Compostela, Spain.|Department of Internal Medicine, Hospital of Santiago de Compostela, Santiago de Compostela, Spain.|Department of Medicine, University of California-San Francisco, San Francisco, CA, USA.
authors.forename: Isabel
authors.initials: I
authors.lastname: Campos-Varela
authors.affiliation: Department of Surgery, University of California-San Francisco, San Francisco, CA, USA.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Dodge
authors.affiliation: Department of Surgery, University of California-San Francisco, San Francisco, CA, USA.
authors.forename: Peter G
authors.initials: PG
authors.lastname: Stock
authors.affiliation: Department of Medicine, University of California-San Francisco, San Francisco, CA, USA. norah.terrault@ucsf.edu.|Department of Surgery, University of California-San Francisco, San Francisco, CA, USA. norah.terrault@ucsf.edu.
authors.forename: Norah A
authors.initials: NA
authors.lastname: Terrault
mesh_terms: D005260:Female; D006084:Graft Rejection / Q000453:epidemiology / Q000209:etiology*; D006085:Graft Survival; D006678:HIV; D006679:HIV Seropositivity / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D012307:Risk Factors; D014019:Tissue Donors; D066027:Transplant Recipients; D014481:United States / Q000453:epidemiology
keywords: diabetes; donor age; donor risk index; race mismatch; survival