title: Metal-Organic Framework Coatings as Cytoprotective Exoskeletons for Living Cells.
abstract: The biomimetic mineralization of metal-organic framework (MOF) material on living cells is reported. ZIF-8 can be crystallized on a living cell surface as an exoskeleton that offers physical protection while allowing transport of essential nutrients, thus maintaining cell viability. The MOF shell prevents cell division, leading to an artificially induced pseudo-hibernation state. Cellular functions can be fully restored upon MOF removal.
authors.affiliation: CSIRO Manufacturing, CSIRO Private Bag 10, Clayton South, Victoria, 3169, Australia. kang.liang@csiro.au.
authors.forename: Kang
authors.initials: K
authors.lastname: Liang
authors.affiliation: CSIRO Manufacturing, CSIRO Private Bag 10, Clayton South, Victoria, 3169, Australia.
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Richardson
authors.affiliation: ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, the Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria, 3010, Australia.
authors.forename: Jiwei
authors.initials: J
authors.lastname: Cui
authors.affiliation: ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, the Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria, 3010, Australia.
authors.forename: Frank
authors.initials: F
authors.lastname: Caruso
authors.affiliation: School of Chemistry and Physics, The University of Adelaide, Adelaide, South Australia, 5005, Australia. christian.doonan@adelaide.edu.au.
authors.forename: Christian J
authors.initials: CJ
authors.lastname: Doonan
authors.affiliation: Institute of Physical and Theoretical Chemistry, Graz University of Technology, Stremayrgasse 9, Graz, 8010, Austria. paolo.falcaro@tugraz.at.
authors.forename: Paolo
authors.initials: P
authors.lastname: Falcaro
mesh_terms: D040761:Biomimetic Materials / Q000737:chemistry / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003460:Crystallization; D019610:Cytoprotection / Q000187:drug effects*; D000073396:Metal-Organic Frameworks / Q000737:chemistry* / Q000494:pharmacology*; D020011:Protective Agents / Q000737:chemistry* / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000187:drug effects
chemical_list: D000073396:Metal-Organic Frameworks; D020011:Protective Agents
keywords: biomimetics; cell coatings; cytoprotection; metal-organic frameworks; nanoporous materials