title: A facile and rapid access to resveratrol derivatives and their radioprotective activity.
abstract: A facile and rapid access to resveratrol derivatives has been achieved based on palladium-catalyzed oxidative Heck reaction of aryl boronic acids with styrenes followed by demethylation in moderate to good yields. A series of resveratrol derivatives with various functional groups has been synthesized easily. The radioprotective activity of synthesized compounds has also been evaluated using rat thymocytes. The results revealed that some resveratrol derivatives efficiently protected the thymocytes from radiation-induced apoptosis.
authors.affiliation: Department of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-1 Gakuencho, Sakai, Osaka 599-8241, Japan.
authors.forename: Saori
authors.initials: S
authors.lastname: Uzura
authors.affiliation: Quantitative RedOx Sensing Team (QRST), Department of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology (QST), Inage-ku, Chiba 263-8555, Japan.
authors.forename: Emiko
authors.initials: E
authors.lastname: Sekine-Suzuki
authors.affiliation: Quantitative RedOx Sensing Team (QRST), Department of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology (QST), Inage-ku, Chiba 263-8555, Japan.
authors.forename: Ikuo
authors.initials: I
authors.lastname: Nakanishi
authors.affiliation: Department of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-1 Gakuencho, Sakai, Osaka 599-8241, Japan.
authors.forename: Motohiro
authors.initials: M
authors.lastname: Sonoda
authors.affiliation: Department of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-1 Gakuencho, Sakai, Osaka 599-8241, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Tanimori
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000528:radiation effects; D001897:Boronic Acids / Q000737:chemistry; D002384:Catalysis; D005720:Gamma Rays; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry; D011837:Radiation-Protective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats; D000077185:Resveratrol; D013267:Stilbenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013343:Styrenes / Q000737:chemistry; D060168:Thymocytes / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects
chemical_list: D001897:Boronic Acids; D011837:Radiation-Protective Agents; D013267:Stilbenes; D013343:Styrenes; D010165:Palladium; D000077185:Resveratrol
keywords: Oxidative Heck reaction; Radioprotector; Resveratrol; Synthesis