title: A Randomized, Comparative Study to Evaluate Efficacy and Safety of Two Injection Volumes of AbobotulinumtoxinA in Treatment of Glabellar Lines.
abstract: BACKGROUND
  Different volumes of 0.9% NaCl may be used to reconstitute abobotulinumtoxinA yielding an injection volume that ranges from 0.05 to 0.1 mL per injection point for treatment of glabellar lines.
  
  
  OBJECTIVE
  To evaluate the efficacy, safety, and subject satisfaction of 2 different injection volumes to deliver the same unit dose of abobotulinumtoxinA for treatment of glabellar lines.
  
  
  METHODS
  This randomized comparative study was conducted using 2 different reconstitution volumes to deliver a fixed unit dose of 10 Speywood units (sU) of abobotulinumtoxinA in either 0.05 mL (labeled volume) or 0.1 mL (twofold volume) per injection point. Evaluations included wrinkle severity, neurophysiological assessment by compound muscle action potential (CMAP), and subject satisfaction.
  
  
  RESULTS
  Use of either injection volume of abobotulinumtoxinA resulted in the early onset of effect, high effectiveness, and long duration of effect. The safety profile and injection pain levels were similar in both groups. The twofold injection volume was shown to be noninferior to the labeled injection volume based on CMAP results.
  
  
  CONCLUSIONS
  A twofold increase in injection volume to 0.1 mL per injection point to deliver 10 sU of abobotulinumtoxinA is effective and safe.
authors.affiliation: Departments of *Neuroscience, and †Medical Sciences, Uppsala University, Uppsala, Sweden; ‡Göteborgs Plastikkirurgiska Center, Gothenburg, Sweden; §Galderma A&C, Uppsala, Sweden; ‖Zenith Healthcare Communications Ltd, Chester, Cheshire, UK.
authors.forename: Anna Rostedt
authors.initials: AR
authors.lastname: Punga
authors.forename: Mohammad
authors.initials: M
authors.lastname: Alimohammadi
authors.forename: Dan
authors.initials: D
authors.lastname: Fagrell
authors.forename: Frida
authors.initials: F
authors.lastname: Nyberg
authors.forename: Diane
authors.initials: D
authors.lastname: Rees
authors.forename: Cindy
authors.initials: C
authors.lastname: Wong
mesh_terms: D065087:Acetylcholine Release Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D000200:Action Potentials; D000328:Adult; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D005546:Forehead; D006801:Humans; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000502:physiology; D010146:Pain / Q000209:etiology; D017060:Patient Satisfaction; D015595:Skin Aging / Q000187:drug effects*
chemical_list: D065087:Acetylcholine Release Inhibitors; D019274:Botulinum Toxins, Type A; C542869:abobotulinumtoxinA