title: Diterpenoid Alkaloids from Delphinium ajacis and Their Anti-RSV Activities.
abstract: Five new diterpenoid alkaloids, ajacisines A-E (1-5), were isolated fromDelphinium ajacis, along with seven known alkaloids (6-12). On the basis of their spectral data (IR, UV, HR-ESI-MS, 1D and 2D NMR) and chemical properties, the structures of compounds1-12were identified. All isolated compounds were evaluated for theirin vitroantiviral activities against respiratory syncytial virus, and compounds3-5and8exhibited moderate to weak effects with IC50values of 75.2 ± 1.1, 35.1 ± 0.6, 10.1 ± 0.3, and 50.2 ± 0.5 µM, respectively.
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Yang
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China.
authors.forename: Yu-Bo
authors.initials: YB
authors.lastname: Zhang
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China.
authors.forename: Ling
authors.initials: L
authors.lastname: Zhuang
authors.affiliation: School of Biomedical Sciences, The University of Hong Kong, Central and Western District, Hong Kong.
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China.
authors.forename: Neng-Hua
authors.initials: NH
authors.lastname: Chen
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China.
authors.forename: Zhong-Nan
authors.initials: ZN
authors.lastname: Wu
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China.
authors.forename: Pan
authors.initials: P
authors.lastname: Li
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China.
authors.forename: Yao-Lan
authors.initials: YL
authors.lastname: Li
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China.
authors.forename: Guo-Cai
authors.initials: GC
authors.lastname: Wang
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D031882:Delphinium / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D018113:Respiratory Syncytial Virus, Human / Q000187:drug effects*
chemical_list: D000470:Alkaloids; D000998:Antiviral Agents; D004224:Diterpenes