title: [Protective action figurations for superoxide dismutase - chondroitin sulfate - catalase bienzyme conjugate after its medicative administration in endotoxin shock].
abstract: Previously it found that the bienzymatic conjugate superoxide dismutase-chondroitin sulfate, catalase (SOD-CHS-CAT) increased the survival rate of rats with endotoxic shock caused by the administration of lipopolysaccharide (LPS). This effect was observed both in preventive (before LPS) and therapeutic conjugate administration (after the administration of LPS). This study shows that the development of endotoxic shock is accompanied by increased levels of NO in the liver, lungs, kidneys, heart; administration of the SOD-CHS-CAT conjugate insignificantly influenced this parameter. At the same time, the changes in blood urea and creatinine suggest the protective effect of the conjugate on renal function, while diverse changes in biochemical parameters studied complicate the formation of the agreed conclusions on the state of other organs.
authors.affiliation: Institute of Experimental Cardiology, Russian Cardiology Research-and-Production Complex, Moscow, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Maksimenko
authors.affiliation: Institute of Experimental Cardiology, Russian Cardiology Research-and-Production Complex, Moscow, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Vavaeva
authors.affiliation: Institute of Experimental Cardiology, Russian Cardiology Research-and-Production Complex, Moscow, Russia.
authors.forename: M A
authors.initials: MA
authors.lastname: Zvyagintseva
authors.affiliation: Institute of Experimental Cardiology, Russian Cardiology Research-and-Production Complex, Moscow, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Abramov
authors.affiliation: Institute of Experimental Cardiology, Russian Cardiology Research-and-Production Complex, Moscow, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Timoshin
authors.affiliation: Institute of Experimental Cardiology, Russian Cardiology Research-and-Production Complex, Moscow, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Vavaev
authors.affiliation: Institute of Experimental Cardiology, Russian Cardiology Research-and-Production Complex, Moscow, Russia.
authors.forename: V L
authors.initials: VL
authors.lastname: Lakomkin
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D002374:Catalase / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D002809:Chondroitin Sulfates / Q000737:chemistry*; D057487:Enzyme Therapy; D008070:Lipopolysaccharides / Q000633:toxicity; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012772:Shock, Septic / Q000188:drug therapy* / Q000517:prevention & control; D013482:Superoxide Dismutase / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D008070:Lipopolysaccharides; D009569:Nitric Oxide; D002809:Chondroitin Sulfates; D002374:Catalase; D013482:Superoxide Dismutase
keywords: antioxidant enzyme therapy; bienzyme superoxide dismutase-chondroitin sulphate-catalase conjugate; endotoxin shock; oxidative stress