title: The Prognostic and Predictive Role of Epidermal Growth Factor Receptor in Surgical Resected Pancreatic Cancer.
abstract: The data regarding the prognostic significance of EGFR (epidermal growth factor receptor) expression and adjuvant therapy in patients with resected pancreatic cancer are insufficient. We retrospectively investigated EGFR status in 357 resected PDAC (pancreatic duct adenocarcinoma) patients using tissue immunohistochemistry and validated the possible role of EGFR expression in predicting prognosis. The analysis was based on excluding the multiple confounding parameters. A negative association was found between overall EGFR status and postoperative survival (p = 0.986). Remarkably, adjuvant chemotherapy and radiotherapy were significantly associated with favorable postoperative survival, which prolonged median overall survival (OS) for 5.8 and 10.2 months (p = 0.009 and p = 0.006, respectively). Kaplan-Meier analysis showed that adjuvant chemotherapy correlated with an obvious survival benefit in the EGFR-positive subgroup rather than in the EGFR-negative subgroup. In the subgroup analyses, chemotherapy was highly associated with increased postoperative survival in the EGFR-negative subgroup (p = 0.002), and radiotherapy had a significant survival benefit in the EGFR-positive subgroup (p = 0.029). This study demonstrated that EGFR expression is not correlated with outcome in resected pancreatic cancer patients. Adjuvant chemotherapy and radiotherapy were significantly associated with improved survival in contrary EGFR expressing subgroup. Further studies of EGFR as a potential target for pancreatic cancer treatment are warranted.
authors.affiliation: Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China. guomeng@fudanpci.org.|Department of Pancreas Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China. guomeng@fudanpci.org.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China. guomeng@fudanpci.org.
authors.forename: Meng
authors.initials: M
authors.lastname: Guo
authors.affiliation: Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China. luoguopei@hotmail.com.|Department of Pancreas Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China. luoguopei@hotmail.com.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China. luoguopei@hotmail.com.
authors.forename: Guopei
authors.initials: G
authors.lastname: Luo
authors.affiliation: Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China. liuchen@fudanpci.org.|Department of Pancreas Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China. liuchen@fudanpci.org.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China. liuchen@fudanpci.org.
authors.forename: Chen
authors.initials: C
authors.lastname: Liu
authors.affiliation: Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China. chenghe@fudanpci.org.|Department of Pancreas Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China. chenghe@fudanpci.org.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China. chenghe@fudanpci.org.
authors.forename: He
authors.initials: H
authors.lastname: Cheng
authors.affiliation: Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China. luyu@fudanpci.org.|Department of Pancreas Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China. luyu@fudanpci.org.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China. luyu@fudanpci.org.
authors.forename: Yu
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China. jinkaizhou@fudanpci.org.|Department of Pancreas Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China. jinkaizhou@fudanpci.org.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China. jinkaizhou@fudanpci.org.
authors.forename: Kaizhou
authors.initials: K
authors.lastname: Jin
authors.affiliation: Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China. liuzuqiang@fudanpci.org.|Department of Pancreas Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China. liuzuqiang@fudanpci.org.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China. liuzuqiang@fudanpci.org.
authors.forename: Zuqiang
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China. longjiang@fudanpci.org.|Department of Pancreas Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China. longjiang@fudanpci.org.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China. longjiang@fudanpci.org.
authors.forename: Jiang
authors.initials: J
authors.lastname: Long
authors.affiliation: Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China. liuliang@fudanpci.org.|Department of Pancreas Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China. liuliang@fudanpci.org.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China. liuliang@fudanpci.org.
authors.forename: Liang
authors.initials: L
authors.lastname: Liu
authors.affiliation: Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China. xujin@fudanpci.org.|Department of Pancreas Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China. xujin@fudanpci.org.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China. xujin@fudanpci.org.
authors.forename: Jin
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China. ilytty@163.com.|Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China. ilytty@163.com.
authors.forename: Dan
authors.initials: D
authors.lastname: Huang
authors.affiliation: Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China. niquanxing@fudanpci.org.|Department of Pancreas Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China. niquanxing@fudanpci.org.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China. niquanxing@fudanpci.org.
authors.forename: Quanxing
authors.initials: Q
authors.lastname: Ni
authors.affiliation: Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China. yuxianjun@fudanpci.org.|Department of Pancreas Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China. yuxianjun@fudanpci.org.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China. yuxianjun@fudanpci.org.
authors.forename: Xianjun
authors.initials: X
authors.lastname: Yu
mesh_terms: D000368:Aged; D015295:Antigens, Tumor-Associated, Carbohydrate; D021441:Carcinoma, Pancreatic Ductal / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D018572:Disease-Free Survival; D066246:ErbB Receptors / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; C578959:carbohydrate antigen 199, human; D066246:ErbB Receptors
keywords: EGFR status; adjuvant therapy; overall survival; pancreatic ductal adenocarcinoma; prognosis