title: Jiang Tang Xiao Ke Granule, a Classic Chinese Herbal Formula, Improves the Effect of Metformin on Lipid and Glucose Metabolism in Diabetic Mice.
abstract: In the present study, the hypoglycemic, hypolipidemic, and antioxidative effects of metformin (MET) combined with Jiang Tang Xiao Ke (JTXK) granule derived from the "Di Huang Tang" were evaluated in mice with type 2 diabetes mellitus (DM) induced by high-fat diet/streptozotocin. DM mice were orally treated with MET (0.19 g/kg) either alone or combined with different doses (1.75, 3.5, or 7 g/kg) of JTXK for 4 weeks. Results showed that the serum and hepatic glucose, lipids, and oxidative stress levels were elevated in DM mice, when compared with the normal mice. MET treatment decreased FBG and serum glucagon levels of DM mice. Combination treatment with MET and JTXK 3.5 g/kg increased the hypoglycemia and insulin sensitivity at 4 weeks when compared with the DM mice treated with MET alone. However, neither MET nor MET/JTXK treatment could completely reverse the hyperglycemia in DM mice. JTXK enhanced the serum triglyceride (TG) and hepatic lipid-lowering effect of MET in a dose-dependent manner in DM mice. JTXK 1.75 and 3.5 g/kg improved the hepatoprotective effect of MET in DM mice. Synergistic effect of combination treatment with MET and JTXK on antioxidant stress was also found in DM mice compared with MET alone.
authors.affiliation: Basic Theory of Chinese Medicine, Preclinical Medicine School, Beijing University of Chinese Medicine, Beijing 100029, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Basic Theory of Chinese Medicine, Preclinical Medicine School, Beijing University of Chinese Medicine, Beijing 100029, China.
authors.forename: Hong
authors.initials: H
authors.lastname: An
authors.affiliation: Department of Pharmacology, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China.
authors.forename: Si-Yuan
authors.initials: SY
authors.lastname: Pan
authors.affiliation: Diabetes Research Center, Beijing University of Chinese Medicine, Beijing 100029, China.
authors.forename: Dan-Dan
authors.initials: DD
authors.lastname: Zhao
authors.affiliation: Basic Theory of Chinese Medicine, Preclinical Medicine School, Beijing University of Chinese Medicine, Beijing 100029, China.
authors.forename: Jia-Cheng
authors.initials: JC
authors.lastname: Zuo
authors.affiliation: Basic Theory of Chinese Medicine, Preclinical Medicine School, Beijing University of Chinese Medicine, Beijing 100029, China.
authors.forename: Xiao-Ke
authors.initials: XK
authors.lastname: Li
authors.affiliation: Basic Theory of Chinese Medicine, Preclinical Medicine School, Beijing University of Chinese Medicine, Beijing 100029, China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Basic Theory of Chinese Medicine, Preclinical Medicine School, Beijing University of Chinese Medicine, Beijing 100029, China.
authors.forename: Qian-Qian
authors.initials: QQ
authors.lastname: Mu
authors.affiliation: Basic Theory of Chinese Medicine, Preclinical Medicine School, Beijing University of Chinese Medicine, Beijing 100029, China.
authors.forename: Na
authors.initials: N
authors.lastname: Yu
authors.affiliation: Basic Theory of Chinese Medicine, Preclinical Medicine School, Beijing University of Chinese Medicine, Beijing 100029, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Diabetes Research Center, Beijing University of Chinese Medicine, Beijing 100029, China.
authors.forename: Fang-Fang
authors.initials: FF
authors.lastname: Mo
authors.affiliation: Diabetes Research Center, Beijing University of Chinese Medicine, Beijing 100029, China.
authors.forename: Si-Hua
authors.initials: SH
authors.lastname: Gao