title: GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half-life in a murine model of sickle cell disease.
authors.affiliation: Department of Physics, Drexel University, Philadelphia, PA, 19104, USA.
authors.forename: Frank A
authors.initials: FA
authors.lastname: Ferrone
mesh_terms: D000755:Anemia, Sickle Cell; D000818:Animals; D004195:Disease Models, Animal; D006207:Half-Life; D006451:Hemoglobin, Sickle; D006454:Hemoglobins; D051379:Mice; D010100:Oxygen
chemical_list: D006451:Hemoglobin, Sickle; D006454:Hemoglobins; D010100:Oxygen
keywords: GBT440; hemoglobin polymerization; sickle cell disease