title: Does cognitive decline decrease health utility value in older adult patients with cancer?
abstract: OBJECTIVE
  Cognitive decline is common among older adults with cancer. The present study aimed to investigate the impact of cognitive decline on health utility value in older adults suffering from cancer.
  
  
  METHODS
  Consecutive patients aged 65 years or older with a primary diagnosis of malignant lymphoma or multiple myeloma were recruited. Patients were asked to complete the EuroQoL-5 (EQ-5D) scale to measure health utility and the Mini-Mental State Examination to assess cognitive decline. The potential impact of cognitive decline was investigated with univariate analysis. A multivariate regression analysis was conducted to control for potential confounding factors.
  
  
  RESULTS
  Complete data were obtained from 87 patients, 29% of whom had cognitive decline. The mean ± SE EQ-5D score for patients with cognitive decline was significantly lower than that for those without cognitive decline (0.67 ± 0.04 vs 0.79 ± 0.03, t = 2.38, P = 0.02). However, multiple regression analysis showed that cognitive decline was not significantly associated with EQ-5D scores. Female sex and lower performance scores (worse physical condition) were significantly associated with EQ-5D scores.
  
  
  CONCLUSIONS
  Cognitive decline may be involved in decreased health utility value in older adult patients with cancer. However, this effect does not seem to be independent, and the patient's physical condition may be a relevant confounding factor.
authors.affiliation: Department of Psychiatry and Cognitive-Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.|Division of Palliative Care and Psycho-oncology, Nagoya City University Hospital, Nagoya, Japan.
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Akechi
authors.affiliation: Department of Psychiatry and Cognitive-Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors.forename: Sayo
authors.initials: S
authors.lastname: Aiki
authors.affiliation: Department of Psychiatry and Cognitive-Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Sugano
authors.affiliation: Department of Psychiatry and Cognitive-Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.|Division of Palliative Care and Psycho-oncology, Nagoya City University Hospital, Nagoya, Japan.
authors.forename: Megumi
authors.initials: M
authors.lastname: Uchida
authors.affiliation: Department of Psychiatry and Cognitive-Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors.forename: Atsuro
authors.initials: A
authors.lastname: Yamada
authors.affiliation: Department of Hematology and Oncology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Komatsu
authors.affiliation: Department of Hematology and Oncology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Ishida
authors.affiliation: Department of Hematology and Oncology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kusumoto
authors.affiliation: Department of Hematology and Oncology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Iida
authors.affiliation: Department of Psychiatry and Cognitive-Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.|Division of Palliative Care and Psycho-oncology, Nagoya City University Hospital, Nagoya, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Okuyama
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D060825:Cognitive Dysfunction / Q000503:physiopathology*; D005260:Female; D006304:Health Status; D006305:Health Status Indicators; D006801:Humans; D007564:Japan; D008223:Lymphoma / Q000473:pathology / Q000523:psychology*; D008297:Male; D009101:Multiple Myeloma / Q000473:pathology / Q000523:psychology*; D015999:Multivariate Analysis; D011788:Quality of Life / Q000523:psychology*; D012044:Regression Analysis; D011795:Surveys and Questionnaires
keywords: cognitive decline; health utility value; oncology; quality of life