title: Family History and Risk of Recurrent Stroke.
abstract: The association between family history of stroke and stroke recurrence remains unclear.
  
  
  
  Using a web-based multicenter stroke registry database, information on history of stroke in first-degree relatives was collected prospectively for acute ischemic stroke patients who were hospitalized within 7 days of onset. The collected information was categorized as follows: type of the affected relative(s) with stroke (paternal, maternal, sibling, or 2 or more) and age of the relative's stroke onset (<50, 50-59, 60-69, and ≥70 years). Stroke recurrence was captured prospectively using a predetermined protocol. Subgroup analyses were performed according to the patient's age at the index stroke.
  
  
  
  Among 7642 patients, 937 (12.3%) had a history of stroke in their first-degree relatives and 475 (6.2%: 201 within and 274 after 3 weeks from index stroke) experienced stroke recurrence (median follow-up, 365 days). In multivariable Cox proportional hazard models, overall family history was not associated with stroke recurrence (hazard ratio, 1.08; 95% confidence interval, 0.81-1.43). However, the details of their family histories, including relative's age at stroke onset (<50 years: hazard ratio, 2.14; 95% confidence interval, 1.004-4.54) and stroke history in a sibling (hazard ratio, 1.67; 95% confidence interval, 1.09-2.58), were independently associated with stroke recurrence after adjusting for potential confounders. The associations appeared to be stronger in young adults with stroke (age, <55 years) than in older stroke patients.
  
  
  
  This study suggests that elevated risks of recurrent stroke are associated with having relatives with early-onset stroke and siblings with stroke histories, implying that additional precautions may be needed in such populations.
authors.affiliation: From the Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (J.-W.C.); Department of Neurology, Cerebrovascular Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea (B.J.K., M.-K.H., M.S.J.); Department of Neurology, Eulji General Hospital, Eulji University, Seoul, Republic of Korea (K.K., J.-M.P.); Department of Neurology, Seoul Medical Center, Republic of Korea (S.-S.P., T.H.P.); Department of Neurology, Ilsan Paik Hospital, Inje University, Goyang, Republic of Korea (Y.-J.C., K.-S.H.); Department of Neurology, Soonchunhyang University Hospital, Seoul, Republic of Korea (K.B.L.); Department of Neurology, Eulji University Hospital, Eulji University, Daejeon, Republic of Korea (J.G.K., Y.K., S.J.L.); Department of Neurology, Dong-A University Hospital, Pusan, Republic of Korea (H.-W.N., D.-H.K., J-K.C.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea (M.-S.O., K.-H.Y., B.-C.L.); Clinical Research Center, Asan Medical Center, Seoul, Republic of Korea (J.S.L.); and Department of Biostatistics, Korea University College of Medicine, Seoul, Republic of Korea (J.L.).
authors.forename: Jong-Won
authors.initials: JW
authors.lastname: Chung
authors.affiliation: From the Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (J.-W.C.); Department of Neurology, Cerebrovascular Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea (B.J.K., M.-K.H., M.S.J.); Department of Neurology, Eulji General Hospital, Eulji University, Seoul, Republic of Korea (K.K., J.-M.P.); Department of Neurology, Seoul Medical Center, Republic of Korea (S.-S.P., T.H.P.); Department of Neurology, Ilsan Paik Hospital, Inje University, Goyang, Republic of Korea (Y.-J.C., K.-S.H.); Department of Neurology, Soonchunhyang University Hospital, Seoul, Republic of Korea (K.B.L.); Department of Neurology, Eulji University Hospital, Eulji University, Daejeon, Republic of Korea (J.G.K., Y.K., S.J.L.); Department of Neurology, Dong-A University Hospital, Pusan, Republic of Korea (H.-W.N., D.-H.K., J-K.C.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea (M.-S.O., K.-H.Y., B.-C.L.); Clinical Research Center, Asan Medical Center, Seoul, Republic of Korea (J.S.L.); and Department of Biostatistics, Korea University College of Medicine, Seoul, Republic of Korea (J.L.).
authors.forename: Beom Joon
authors.initials: BJ
authors.lastname: Kim
authors.affiliation: From the Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (J.-W.C.); Department of Neurology, Cerebrovascular Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea (B.J.K., M.-K.H., M.S.J.); Department of Neurology, Eulji General Hospital, Eulji University, Seoul, Republic of Korea (K.K., J.-M.P.); Department of Neurology, Seoul Medical Center, Republic of Korea (S.-S.P., T.H.P.); Department of Neurology, Ilsan Paik Hospital, Inje University, Goyang, Republic of Korea (Y.-J.C., K.-S.H.); Department of Neurology, Soonchunhyang University Hospital, Seoul, Republic of Korea (K.B.L.); Department of Neurology, Eulji University Hospital, Eulji University, Daejeon, Republic of Korea (J.G.K., Y.K., S.J.L.); Department of Neurology, Dong-A University Hospital, Pusan, Republic of Korea (H.-W.N., D.-H.K., J-K.C.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea (M.-S.O., K.-H.Y., B.-C.L.); Clinical Research Center, Asan Medical Center, Seoul, Republic of Korea (J.S.L.); and Department of Biostatistics, Korea University College of Medicine, Seoul, Republic of Korea (J.L.).
authors.forename: Moon-Ku
authors.initials: MK
authors.lastname: Han
authors.affiliation: From the Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (J.-W.C.); Department of Neurology, Cerebrovascular Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea (B.J.K., M.-K.H., M.S.J.); Department of Neurology, Eulji General Hospital, Eulji University, Seoul, Republic of Korea (K.K., J.-M.P.); Department of Neurology, Seoul Medical Center, Republic of Korea (S.-S.P., T.H.P.); Department of Neurology, Ilsan Paik Hospital, Inje University, Goyang, Republic of Korea (Y.-J.C., K.-S.H.); Department of Neurology, Soonchunhyang University Hospital, Seoul, Republic of Korea (K.B.L.); Department of Neurology, Eulji University Hospital, Eulji University, Daejeon, Republic of Korea (J.G.K., Y.K., S.J.L.); Department of Neurology, Dong-A University Hospital, Pusan, Republic of Korea (H.-W.N., D.-H.K., J-K.C.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea (M.-S.O., K.-H.Y., B.-C.L.); Clinical Research Center, Asan Medical Center, Seoul, Republic of Korea (J.S.L.); and Department of Biostatistics, Korea University College of Medicine, Seoul, Republic of Korea (J.L.).
authors.forename: Kyusik
authors.initials: K
authors.lastname: Kang
authors.affiliation: From the Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (J.-W.C.); Department of Neurology, Cerebrovascular Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea (B.J.K., M.-K.H., M.S.J.); Department of Neurology, Eulji General Hospital, Eulji University, Seoul, Republic of Korea (K.K., J.-M.P.); Department of Neurology, Seoul Medical Center, Republic of Korea (S.-S.P., T.H.P.); Department of Neurology, Ilsan Paik Hospital, Inje University, Goyang, Republic of Korea (Y.-J.C., K.-S.H.); Department of Neurology, Soonchunhyang University Hospital, Seoul, Republic of Korea (K.B.L.); Department of Neurology, Eulji University Hospital, Eulji University, Daejeon, Republic of Korea (J.G.K., Y.K., S.J.L.); Department of Neurology, Dong-A University Hospital, Pusan, Republic of Korea (H.-W.N., D.-H.K., J-K.C.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea (M.-S.O., K.-H.Y., B.-C.L.); Clinical Research Center, Asan Medical Center, Seoul, Republic of Korea (J.S.L.); and Department of Biostatistics, Korea University College of Medicine, Seoul, Republic of Korea (J.L.).
authors.forename: Jong-Moo
authors.initials: JM
authors.lastname: Park
authors.affiliation: From the Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (J.-W.C.); Department of Neurology, Cerebrovascular Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea (B.J.K., M.-K.H., M.S.J.); Department of Neurology, Eulji General Hospital, Eulji University, Seoul, Republic of Korea (K.K., J.-M.P.); Department of Neurology, Seoul Medical Center, Republic of Korea (S.-S.P., T.H.P.); Department of Neurology, Ilsan Paik Hospital, Inje University, Goyang, Republic of Korea (Y.-J.C., K.-S.H.); Department of Neurology, Soonchunhyang University Hospital, Seoul, Republic of Korea (K.B.L.); Department of Neurology, Eulji University Hospital, Eulji University, Daejeon, Republic of Korea (J.G.K., Y.K., S.J.L.); Department of Neurology, Dong-A University Hospital, Pusan, Republic of Korea (H.-W.N., D.-H.K., J-K.C.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea (M.-S.O., K.-H.Y., B.-C.L.); Clinical Research Center, Asan Medical Center, Seoul, Republic of Korea (J.S.L.); and Department of Biostatistics, Korea University College of Medicine, Seoul, Republic of Korea (J.L.).
authors.forename: Sang-Soon
authors.initials: SS
authors.lastname: Park
authors.affiliation: From the Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (J.-W.C.); Department of Neurology, Cerebrovascular Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea (B.J.K., M.-K.H., M.S.J.); Department of Neurology, Eulji General Hospital, Eulji University, Seoul, Republic of Korea (K.K., J.-M.P.); Department of Neurology, Seoul Medical Center, Republic of Korea (S.-S.P., T.H.P.); Department of Neurology, Ilsan Paik Hospital, Inje University, Goyang, Republic of Korea (Y.-J.C., K.-S.H.); Department of Neurology, Soonchunhyang University Hospital, Seoul, Republic of Korea (K.B.L.); Department of Neurology, Eulji University Hospital, Eulji University, Daejeon, Republic of Korea (J.G.K., Y.K., S.J.L.); Department of Neurology, Dong-A University Hospital, Pusan, Republic of Korea (H.-W.N., D.-H.K., J-K.C.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea (M.-S.O., K.-H.Y., B.-C.L.); Clinical Research Center, Asan Medical Center, Seoul, Republic of Korea (J.S.L.); and Department of Biostatistics, Korea University College of Medicine, Seoul, Republic of Korea (J.L.).
authors.forename: Tai Hwan
authors.initials: TH
authors.lastname: Park
authors.affiliation: From the Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (J.-W.C.); Department of Neurology, Cerebrovascular Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea (B.J.K., M.-K.H., M.S.J.); Department of Neurology, Eulji General Hospital, Eulji University, Seoul, Republic of Korea (K.K., J.-M.P.); Department of Neurology, Seoul Medical Center, Republic of Korea (S.-S.P., T.H.P.); Department of Neurology, Ilsan Paik Hospital, Inje University, Goyang, Republic of Korea (Y.-J.C., K.-S.H.); Department of Neurology, Soonchunhyang University Hospital, Seoul, Republic of Korea (K.B.L.); Department of Neurology, Eulji University Hospital, Eulji University, Daejeon, Republic of Korea (J.G.K., Y.K., S.J.L.); Department of Neurology, Dong-A University Hospital, Pusan, Republic of Korea (H.-W.N., D.-H.K., J-K.C.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea (M.-S.O., K.-H.Y., B.-C.L.); Clinical Research Center, Asan Medical Center, Seoul, Republic of Korea (J.S.L.); and Department of Biostatistics, Korea University College of Medicine, Seoul, Republic of Korea (J.L.).
authors.forename: Yong-Jin
authors.initials: YJ
authors.lastname: Cho
authors.affiliation: From the Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (J.-W.C.); Department of Neurology, Cerebrovascular Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea (B.J.K., M.-K.H., M.S.J.); Department of Neurology, Eulji General Hospital, Eulji University, Seoul, Republic of Korea (K.K., J.-M.P.); Department of Neurology, Seoul Medical Center, Republic of Korea (S.-S.P., T.H.P.); Department of Neurology, Ilsan Paik Hospital, Inje University, Goyang, Republic of Korea (Y.-J.C., K.-S.H.); Department of Neurology, Soonchunhyang University Hospital, Seoul, Republic of Korea (K.B.L.); Department of Neurology, Eulji University Hospital, Eulji University, Daejeon, Republic of Korea (J.G.K., Y.K., S.J.L.); Department of Neurology, Dong-A University Hospital, Pusan, Republic of Korea (H.-W.N., D.-H.K., J-K.C.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea (M.-S.O., K.-H.Y., B.-C.L.); Clinical Research Center, Asan Medical Center, Seoul, Republic of Korea (J.S.L.); and Department of Biostatistics, Korea University College of Medicine, Seoul, Republic of Korea (J.L.).
authors.forename: Keun-Sik
authors.initials: KS
authors.lastname: Hong
authors.affiliation: From the Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (J.-W.C.); Department of Neurology, Cerebrovascular Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea (B.J.K., M.-K.H., M.S.J.); Department of Neurology, Eulji General Hospital, Eulji University, Seoul, Republic of Korea (K.K., J.-M.P.); Department of Neurology, Seoul Medical Center, Republic of Korea (S.-S.P., T.H.P.); Department of Neurology, Ilsan Paik Hospital, Inje University, Goyang, Republic of Korea (Y.-J.C., K.-S.H.); Department of Neurology, Soonchunhyang University Hospital, Seoul, Republic of Korea (K.B.L.); Department of Neurology, Eulji University Hospital, Eulji University, Daejeon, Republic of Korea (J.G.K., Y.K., S.J.L.); Department of Neurology, Dong-A University Hospital, Pusan, Republic of Korea (H.-W.N., D.-H.K., J-K.C.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea (M.-S.O., K.-H.Y., B.-C.L.); Clinical Research Center, Asan Medical Center, Seoul, Republic of Korea (J.S.L.); and Department of Biostatistics, Korea University College of Medicine, Seoul, Republic of Korea (J.L.).
authors.forename: Kyung Bok
authors.initials: KB
authors.lastname: Lee
authors.affiliation: From the Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (J.-W.C.); Department of Neurology, Cerebrovascular Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea (B.J.K., M.-K.H., M.S.J.); Department of Neurology, Eulji General Hospital, Eulji University, Seoul, Republic of Korea (K.K., J.-M.P.); Department of Neurology, Seoul Medical Center, Republic of Korea (S.-S.P., T.H.P.); Department of Neurology, Ilsan Paik Hospital, Inje University, Goyang, Republic of Korea (Y.-J.C., K.-S.H.); Department of Neurology, Soonchunhyang University Hospital, Seoul, Republic of Korea (K.B.L.); Department of Neurology, Eulji University Hospital, Eulji University, Daejeon, Republic of Korea (J.G.K., Y.K., S.J.L.); Department of Neurology, Dong-A University Hospital, Pusan, Republic of Korea (H.-W.N., D.-H.K., J-K.C.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea (M.-S.O., K.-H.Y., B.-C.L.); Clinical Research Center, Asan Medical Center, Seoul, Republic of Korea (J.S.L.); and Department of Biostatistics, Korea University College of Medicine, Seoul, Republic of Korea (J.L.).
authors.forename: Jae Guk
authors.initials: JG
authors.lastname: Kim
authors.affiliation: From the Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (J.-W.C.); Department of Neurology, Cerebrovascular Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea (B.J.K., M.-K.H., M.S.J.); Department of Neurology, Eulji General Hospital, Eulji University, Seoul, Republic of Korea (K.K., J.-M.P.); Department of Neurology, Seoul Medical Center, Republic of Korea (S.-S.P., T.H.P.); Department of Neurology, Ilsan Paik Hospital, Inje University, Goyang, Republic of Korea (Y.-J.C., K.-S.H.); Department of Neurology, Soonchunhyang University Hospital, Seoul, Republic of Korea (K.B.L.); Department of Neurology, Eulji University Hospital, Eulji University, Daejeon, Republic of Korea (J.G.K., Y.K., S.J.L.); Department of Neurology, Dong-A University Hospital, Pusan, Republic of Korea (H.-W.N., D.-H.K., J-K.C.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea (M.-S.O., K.-H.Y., B.-C.L.); Clinical Research Center, Asan Medical Center, Seoul, Republic of Korea (J.S.L.); and Department of Biostatistics, Korea University College of Medicine, Seoul, Republic of Korea (J.L.).
authors.forename: Youngchai
authors.initials: Y
authors.lastname: Ko
authors.affiliation: From the Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (J.-W.C.); Department of Neurology, Cerebrovascular Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea (B.J.K., M.-K.H., M.S.J.); Department of Neurology, Eulji General Hospital, Eulji University, Seoul, Republic of Korea (K.K., J.-M.P.); Department of Neurology, Seoul Medical Center, Republic of Korea (S.-S.P., T.H.P.); Department of Neurology, Ilsan Paik Hospital, Inje University, Goyang, Republic of Korea (Y.-J.C., K.-S.H.); Department of Neurology, Soonchunhyang University Hospital, Seoul, Republic of Korea (K.B.L.); Department of Neurology, Eulji University Hospital, Eulji University, Daejeon, Republic of Korea (J.G.K., Y.K., S.J.L.); Department of Neurology, Dong-A University Hospital, Pusan, Republic of Korea (H.-W.N., D.-H.K., J-K.C.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea (M.-S.O., K.-H.Y., B.-C.L.); Clinical Research Center, Asan Medical Center, Seoul, Republic of Korea (J.S.L.); and Department of Biostatistics, Korea University College of Medicine, Seoul, Republic of Korea (J.L.).
authors.forename: SooJoo
authors.initials: S
authors.lastname: Lee
authors.affiliation: From the Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (J.-W.C.); Department of Neurology, Cerebrovascular Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea (B.J.K., M.-K.H., M.S.J.); Department of Neurology, Eulji General Hospital, Eulji University, Seoul, Republic of Korea (K.K., J.-M.P.); Department of Neurology, Seoul Medical Center, Republic of Korea (S.-S.P., T.H.P.); Department of Neurology, Ilsan Paik Hospital, Inje University, Goyang, Republic of Korea (Y.-J.C., K.-S.H.); Department of Neurology, Soonchunhyang University Hospital, Seoul, Republic of Korea (K.B.L.); Department of Neurology, Eulji University Hospital, Eulji University, Daejeon, Republic of Korea (J.G.K., Y.K., S.J.L.); Department of Neurology, Dong-A University Hospital, Pusan, Republic of Korea (H.-W.N., D.-H.K., J-K.C.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea (M.-S.O., K.-H.Y., B.-C.L.); Clinical Research Center, Asan Medical Center, Seoul, Republic of Korea (J.S.L.); and Department of Biostatistics, Korea University College of Medicine, Seoul, Republic of Korea (J.L.).
authors.forename: Hyun-Wook
authors.initials: HW
authors.lastname: Nah
authors.affiliation: From the Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (J.-W.C.); Department of Neurology, Cerebrovascular Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea (B.J.K., M.-K.H., M.S.J.); Department of Neurology, Eulji General Hospital, Eulji University, Seoul, Republic of Korea (K.K., J.-M.P.); Department of Neurology, Seoul Medical Center, Republic of Korea (S.-S.P., T.H.P.); Department of Neurology, Ilsan Paik Hospital, Inje University, Goyang, Republic of Korea (Y.-J.C., K.-S.H.); Department of Neurology, Soonchunhyang University Hospital, Seoul, Republic of Korea (K.B.L.); Department of Neurology, Eulji University Hospital, Eulji University, Daejeon, Republic of Korea (J.G.K., Y.K., S.J.L.); Department of Neurology, Dong-A University Hospital, Pusan, Republic of Korea (H.-W.N., D.-H.K., J-K.C.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea (M.-S.O., K.-H.Y., B.-C.L.); Clinical Research Center, Asan Medical Center, Seoul, Republic of Korea (J.S.L.); and Department of Biostatistics, Korea University College of Medicine, Seoul, Republic of Korea (J.L.).
authors.forename: Dae-Hyun
authors.initials: DH
authors.lastname: Kim
authors.affiliation: From the Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (J.-W.C.); Department of Neurology, Cerebrovascular Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea (B.J.K., M.-K.H., M.S.J.); Department of Neurology, Eulji General Hospital, Eulji University, Seoul, Republic of Korea (K.K., J.-M.P.); Department of Neurology, Seoul Medical Center, Republic of Korea (S.-S.P., T.H.P.); Department of Neurology, Ilsan Paik Hospital, Inje University, Goyang, Republic of Korea (Y.-J.C., K.-S.H.); Department of Neurology, Soonchunhyang University Hospital, Seoul, Republic of Korea (K.B.L.); Department of Neurology, Eulji University Hospital, Eulji University, Daejeon, Republic of Korea (J.G.K., Y.K., S.J.L.); Department of Neurology, Dong-A University Hospital, Pusan, Republic of Korea (H.-W.N., D.-H.K., J-K.C.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea (M.-S.O., K.-H.Y., B.-C.L.); Clinical Research Center, Asan Medical Center, Seoul, Republic of Korea (J.S.L.); and Department of Biostatistics, Korea University College of Medicine, Seoul, Republic of Korea (J.L.).
authors.forename: Jae-Kwan
authors.initials: JK
authors.lastname: Cha
authors.affiliation: From the Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (J.-W.C.); Department of Neurology, Cerebrovascular Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea (B.J.K., M.-K.H., M.S.J.); Department of Neurology, Eulji General Hospital, Eulji University, Seoul, Republic of Korea (K.K., J.-M.P.); Department of Neurology, Seoul Medical Center, Republic of Korea (S.-S.P., T.H.P.); Department of Neurology, Ilsan Paik Hospital, Inje University, Goyang, Republic of Korea (Y.-J.C., K.-S.H.); Department of Neurology, Soonchunhyang University Hospital, Seoul, Republic of Korea (K.B.L.); Department of Neurology, Eulji University Hospital, Eulji University, Daejeon, Republic of Korea (J.G.K., Y.K., S.J.L.); Department of Neurology, Dong-A University Hospital, Pusan, Republic of Korea (H.-W.N., D.-H.K., J-K.C.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea (M.-S.O., K.-H.Y., B.-C.L.); Clinical Research Center, Asan Medical Center, Seoul, Republic of Korea (J.S.L.); and Department of Biostatistics, Korea University College of Medicine, Seoul, Republic of Korea (J.L.).
authors.forename: Mi-Sun
authors.initials: MS
authors.lastname: Oh
authors.affiliation: From the Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (J.-W.C.); Department of Neurology, Cerebrovascular Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea (B.J.K., M.-K.H., M.S.J.); Department of Neurology, Eulji General Hospital, Eulji University, Seoul, Republic of Korea (K.K., J.-M.P.); Department of Neurology, Seoul Medical Center, Republic of Korea (S.-S.P., T.H.P.); Department of Neurology, Ilsan Paik Hospital, Inje University, Goyang, Republic of Korea (Y.-J.C., K.-S.H.); Department of Neurology, Soonchunhyang University Hospital, Seoul, Republic of Korea (K.B.L.); Department of Neurology, Eulji University Hospital, Eulji University, Daejeon, Republic of Korea (J.G.K., Y.K., S.J.L.); Department of Neurology, Dong-A University Hospital, Pusan, Republic of Korea (H.-W.N., D.-H.K., J-K.C.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea (M.-S.O., K.-H.Y., B.-C.L.); Clinical Research Center, Asan Medical Center, Seoul, Republic of Korea (J.S.L.); and Department of Biostatistics, Korea University College of Medicine, Seoul, Republic of Korea (J.L.).
authors.forename: Kyung-Ho
authors.initials: KH
authors.lastname: Yu
authors.affiliation: From the Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (J.-W.C.); Department of Neurology, Cerebrovascular Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea (B.J.K., M.-K.H., M.S.J.); Department of Neurology, Eulji General Hospital, Eulji University, Seoul, Republic of Korea (K.K., J.-M.P.); Department of Neurology, Seoul Medical Center, Republic of Korea (S.-S.P., T.H.P.); Department of Neurology, Ilsan Paik Hospital, Inje University, Goyang, Republic of Korea (Y.-J.C., K.-S.H.); Department of Neurology, Soonchunhyang University Hospital, Seoul, Republic of Korea (K.B.L.); Department of Neurology, Eulji University Hospital, Eulji University, Daejeon, Republic of Korea (J.G.K., Y.K., S.J.L.); Department of Neurology, Dong-A University Hospital, Pusan, Republic of Korea (H.-W.N., D.-H.K., J-K.C.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea (M.-S.O., K.-H.Y., B.-C.L.); Clinical Research Center, Asan Medical Center, Seoul, Republic of Korea (J.S.L.); and Department of Biostatistics, Korea University College of Medicine, Seoul, Republic of Korea (J.L.).
authors.forename: Byung-Chul
authors.initials: BC
authors.lastname: Lee
authors.affiliation: From the Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (J.-W.C.); Department of Neurology, Cerebrovascular Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea (B.J.K., M.-K.H., M.S.J.); Department of Neurology, Eulji General Hospital, Eulji University, Seoul, Republic of Korea (K.K., J.-M.P.); Department of Neurology, Seoul Medical Center, Republic of Korea (S.-S.P., T.H.P.); Department of Neurology, Ilsan Paik Hospital, Inje University, Goyang, Republic of Korea (Y.-J.C., K.-S.H.); Department of Neurology, Soonchunhyang University Hospital, Seoul, Republic of Korea (K.B.L.); Department of Neurology, Eulji University Hospital, Eulji University, Daejeon, Republic of Korea (J.G.K., Y.K., S.J.L.); Department of Neurology, Dong-A University Hospital, Pusan, Republic of Korea (H.-W.N., D.-H.K., J-K.C.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea (M.-S.O., K.-H.Y., B.-C.L.); Clinical Research Center, Asan Medical Center, Seoul, Republic of Korea (J.S.L.); and Department of Biostatistics, Korea University College of Medicine, Seoul, Republic of Korea (J.L.).
authors.forename: Myung Suk
authors.initials: MS
authors.lastname: Jang
authors.affiliation: From the Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (J.-W.C.); Department of Neurology, Cerebrovascular Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea (B.J.K., M.-K.H., M.S.J.); Department of Neurology, Eulji General Hospital, Eulji University, Seoul, Republic of Korea (K.K., J.-M.P.); Department of Neurology, Seoul Medical Center, Republic of Korea (S.-S.P., T.H.P.); Department of Neurology, Ilsan Paik Hospital, Inje University, Goyang, Republic of Korea (Y.-J.C., K.-S.H.); Department of Neurology, Soonchunhyang University Hospital, Seoul, Republic of Korea (K.B.L.); Department of Neurology, Eulji University Hospital, Eulji University, Daejeon, Republic of Korea (J.G.K., Y.K., S.J.L.); Department of Neurology, Dong-A University Hospital, Pusan, Republic of Korea (H.-W.N., D.-H.K., J-K.C.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea (M.-S.O., K.-H.Y., B.-C.L.); Clinical Research Center, Asan Medical Center, Seoul, Republic of Korea (J.S.L.); and Department of Biostatistics, Korea University College of Medicine, Seoul, Republic of Korea (J.L.).
authors.forename: Ji Sung
authors.initials: JS
authors.lastname: Lee
authors.affiliation: From the Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (J.-W.C.); Department of Neurology, Cerebrovascular Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea (B.J.K., M.-K.H., M.S.J.); Department of Neurology, Eulji General Hospital, Eulji University, Seoul, Republic of Korea (K.K., J.-M.P.); Department of Neurology, Seoul Medical Center, Republic of Korea (S.-S.P., T.H.P.); Department of Neurology, Ilsan Paik Hospital, Inje University, Goyang, Republic of Korea (Y.-J.C., K.-S.H.); Department of Neurology, Soonchunhyang University Hospital, Seoul, Republic of Korea (K.B.L.); Department of Neurology, Eulji University Hospital, Eulji University, Daejeon, Republic of Korea (J.G.K., Y.K., S.J.L.); Department of Neurology, Dong-A University Hospital, Pusan, Republic of Korea (H.-W.N., D.-H.K., J-K.C.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea (M.-S.O., K.-H.Y., B.-C.L.); Clinical Research Center, Asan Medical Center, Seoul, Republic of Korea (J.S.L.); and Department of Biostatistics, Korea University College of Medicine, Seoul, Republic of Korea (J.L.). jyleeuf@korea.ac.kr braindoc@snu.ac.kr.
authors.forename: Juneyoung
authors.initials: J
authors.lastname: Lee
authors.affiliation: From the Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (J.-W.C.); Department of Neurology, Cerebrovascular Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea (B.J.K., M.-K.H., M.S.J.); Department of Neurology, Eulji General Hospital, Eulji University, Seoul, Republic of Korea (K.K., J.-M.P.); Department of Neurology, Seoul Medical Center, Republic of Korea (S.-S.P., T.H.P.); Department of Neurology, Ilsan Paik Hospital, Inje University, Goyang, Republic of Korea (Y.-J.C., K.-S.H.); Department of Neurology, Soonchunhyang University Hospital, Seoul, Republic of Korea (K.B.L.); Department of Neurology, Eulji University Hospital, Eulji University, Daejeon, Republic of Korea (J.G.K., Y.K., S.J.L.); Department of Neurology, Dong-A University Hospital, Pusan, Republic of Korea (H.-W.N., D.-H.K., J-K.C.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea (M.-S.O., K.-H.Y., B.-C.L.); Clinical Research Center, Asan Medical Center, Seoul, Republic of Korea (J.S.L.); and Department of Biostatistics, Korea University College of Medicine, Seoul, Republic of Korea (J.L.). jyleeuf@korea.ac.kr braindoc@snu.ac.kr.
authors.forename: Hee-Joon
authors.initials: HJ
authors.lastname: Bae
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000209:etiology*; D016208:Databases, Factual; D005190:Family; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012008:Recurrence; D012042:Registries; D012306:Risk; D018570:Risk Assessment; D020521:Stroke / Q000209:etiology*
keywords: ischemia; prognosis; proportional hazard models; risk assessment; stroke