title: Increased survivin expression and its association with clinical parameters of congenital choledochal cysts.
abstract: The aim of the current study was to investigate survivin expression in congenital choledochal cysts (CCCs), and its associations with clinical parameters of CCCs. In total, 121 children with CCCs were included in this study as the case group, and their cysts were staged according to the Todani classification system. Additionally, 49 normal gallbladder specimens from healthy children were included as the control group. Survivin detection was conducted using immunohistochemical staining. Associations between positive survivin expression and clinical parameters of CCCs were then analyzed. Positive survivin expression was observed in the cytoplasm, and was seen as granular with yellow or dark brown staining. In the case group, positive survivin expression was detected in most tissues. Specifically, compared to that of normal tissues, the cystic-shaped and fusiform-shaped CCC tissues had significantly higher positive survivin expression rates (all P < 0.05). Importantly, positive survivin expression was also shown to be significantly associated with gender and histological type (both P < 0.05). In conclusion, increased survivin expression was observed in CCC tissues, and was correlated with certain clinical parameters of CCCs, suggesting a possible prognostic value of survivin for CCC progression.
authors.affiliation: Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.|Department of General Surgery, Shenzhen Children's Hospital, Shenzhen, China.
authors.forename: Z G
authors.initials: ZG
authors.lastname: Wu
authors.affiliation: Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: G X
authors.initials: GX
authors.lastname: Li
authors.affiliation: Department of General Surgery, Shenzhen Children's Hospital, Shenzhen, China.
authors.forename: B
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Shenzhen Children's Hospital, Shenzhen, China.
authors.forename: Z M
authors.initials: ZM
authors.lastname: Chen
authors.affiliation: Department of General Surgery, Shenzhen Children's Hospital, Shenzhen, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Feng
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D015529:Choledochal Cyst / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D005260:Female; D005704:Gallbladder / Q000378:metabolism; D006801:Humans; D007223:Infant; D051034:Inhibitor of Apoptosis Proteins / Q000235:genetics* / Q000378:metabolism; D008297:Male; D000077022:Survivin
chemical_list: C107489:BIRC5 protein, human; D015415:Biomarkers; D051034:Inhibitor of Apoptosis Proteins; D000077022:Survivin