title: The clinical significance of fascin expression in a newly diagnosed primary glioblastoma.
abstract: The actin-binding protein fascin has been associated with clinically aggressive tumors and poor prognosis. The purpose of this study was to investigate possibility of fascin expression as a prognostic factor in a newly diagnosed primary glioblastoma (GBM). Between July 2007 and December 2013, 37 out of 126 patients diagnosed with GBM satisfied the following inclusion criteria: (1) the presence of immunohistochemically-available tissue, (2) a new primary GBM, (3) gross-total resection, and (4) standardized adjuvant treatment, known as the Stupp regimen. The median follow-up period was 18 months (range 5-95). According to the staining intensity of fascin, progression-free survival (PFS) in the low-intensity fascin group (median PFS 9.0 months; 95 % CI 6.0-12.0) was longer than PFS in the high-intensity fascin group (median PFS 7.0 months; 95 % CI 5.6-10.4; p = 0.024). Overall survival (OS) in the low-intensity fascin group (median OS 20.0 months; 95 % CI 17.7-22.4) was longer than OS in the high-intensity fascin group (median OS 13.0 months; 95 % CI 8.2-17.8; p = 0.031). And, the staining intensity of fascin was a statistically significant factor in PFS and OS according to univariate and multivariate analyses (univariate analysis p = 0.043 and p = 0.043; multivariate analysis p = 0.041 and p = 0.044). Our clinical study showed that fascin expression intensity may be correlated with clinical outcomes of a newly diagnosed primary GBM, especially with regard to PFS and OS.
authors.affiliation: Department of Neurosurgery, College of Medicine, Chung-Ang University, Seoul, Republic of Korea.
authors.forename: Ki-Su
authors.initials: KS
authors.lastname: Park
authors.affiliation: Department of Pathology, Kyungpook National University School of Medicine, Daegu, Republic of Korea.
authors.forename: Hye Won
authors.initials: HW
authors.lastname: Lee
authors.affiliation: Department of Neurosurgery, Kyungpook National University School of Medicine, 50, Samduk 2-Ga, Jung-Gu, Daegu, 700-721, Republic of Korea.
authors.forename: Seong-Hyun
authors.initials: SH
authors.lastname: Park
authors.affiliation: Department of Pathology, Kyungpook National University School of Medicine, Daegu, Republic of Korea.
authors.forename: Tae In
authors.initials: TI
authors.lastname: Park
authors.affiliation: Department of Neurosurgery, Kyungpook National University School of Medicine, 50, Samduk 2-Ga, Jung-Gu, Daegu, 700-721, Republic of Korea. jhwang@knu.ac.kr.
authors.forename: Jeong-Hyun
authors.initials: JH
authors.lastname: Hwang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D001932:Brain Neoplasms / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism*; D018572:Disease-Free Survival; D005260:Female; D005909:Glioblastoma / Q000378:metabolism*; D006801:Humans; D008297:Male; D008840:Microfilament Proteins / Q000378:metabolism*; D008875:Middle Aged; D012189:Retrospective Studies; D046888:Tissue Array Analysis; D055815:Young Adult
chemical_list: D002352:Carrier Proteins; D008840:Microfilament Proteins; C020324:fascin
keywords: Fascin; Glioblastoma; Overall; Progression-free survival; Survival