title: Causative Microorganisms of Infectious Endophthalmitis: A 5-Year Retrospective Study.
abstract: This study aimed to identify the microbial etiology of infectious endophthalmitis and to determine the antibacterial susceptibilities of bacterial isolates at an eye hospital in South China. A retrospective analysis was carried out on 330 patients with clinically diagnosed infectious endophthalmitis who underwent microbiological evaluation from January 2010 to December 2014. Of the 330 patients, 193 patients (58.5%) had posttraumatic endophthalmitis, 67 patients (20.3%) had postoperative endophthalmitis, 61 patients (18.5%) had endogenous endophthalmitis, and 9 patients (2.7%) had postcorneal infective endophthalmitis. Of the 105 cases (31.8%) of culture-positive endophthalmitis, 79 cases (75.2%) had bacterial growth and 26 cases (24.8%) had fungal growth. In posttraumatic endophthalmitis, Gram-positive bacteria were the predominant species, followed by Gram-negative bacteria and fungi. In endogenous endophthalmitis, Gram-negative bacteria were the predominant species, followed by fungi and Gram-positive bacteria. In postsurgical endophthalmitis, all infections were bacterial. However, in postcorneal infective endophthalmitis, all infections were fungal. Overall, levofloxacin showed the highest activity against bacterial isolates. There was a significant difference in the susceptibility to tobramycin between the isolates from posttraumatic and postoperative endophthalmitis (p < 0.05). The results of this study identify the microbial spectrum of infectious endophthalmitis in this clinical setting.
authors.affiliation: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Key Laboratory of Ophthalmology and Visual Science, Sun Yat-sen University, 54 Xianlie Road, Guangzhou, Guangdong 510060, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Duan
authors.affiliation: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Key Laboratory of Ophthalmology and Visual Science, Sun Yat-sen University, 54 Xianlie Road, Guangzhou, Guangdong 510060, China.
authors.forename: Kaili
authors.identifier: 0000-0003-3606-683X
authors.initials: K
authors.lastname: Wu
authors.affiliation: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Key Laboratory of Ophthalmology and Visual Science, Sun Yat-sen University, 54 Xianlie Road, Guangzhou, Guangdong 510060, China.
authors.forename: Jingyu
authors.initials: J
authors.lastname: Liao
authors.affiliation: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Key Laboratory of Ophthalmology and Visual Science, Sun Yat-sen University, 54 Xianlie Road, Guangzhou, Guangdong 510060, China.
authors.forename: Yongxin
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Key Laboratory of Ophthalmology and Visual Science, Sun Yat-sen University, 54 Xianlie Road, Guangzhou, Guangdong 510060, China.
authors.forename: Zhaohui
authors.identifier: 0000-0002-6024-2461
authors.initials: Z
authors.lastname: Yuan
authors.affiliation: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Key Laboratory of Ophthalmology and Visual Science, Sun Yat-sen University, 54 Xianlie Road, Guangzhou, Guangdong 510060, China.
authors.forename: Junlian
authors.initials: J
authors.lastname: Tan
authors.affiliation: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Key Laboratory of Ophthalmology and Visual Science, Sun Yat-sen University, 54 Xianlie Road, Guangzhou, Guangdong 510060, China.
authors.forename: Xiaofeng
authors.identifier: 0000-0002-4596-2196
authors.initials: X
authors.lastname: Lin