title: Anti-neuroinflammatory constituents from the fungus Penicillium purpurogenum MHZ 111.
abstract: A new dihydroisocoumarin (1) and a new coumarin (2), along with eight known metabolites (3-10), were isolated from the solid substrate fermentation cultures of the fungus Penicillium purpurogenum MHZ 111. Their structures were elucidated by extensive spectroscopic analysis and comparison of their spectroscopic and physicochemical data with the literature values. Compounds 2 and 8 showed inhibition of nitric oxide production in lipopolysaccharide-activated BV-2 microglial cells with IC50values of 26.5 and 52.7 μM, respectively.
authors.affiliation: a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , P.R. China.|b School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing , P.R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Sun
authors.affiliation: a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , P.R. China.
authors.forename: Zhi-Xiang
authors.initials: ZX
authors.lastname: Zhu
authors.affiliation: a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , P.R. China.
authors.forename: Yue-Lin
authors.initials: YL
authors.lastname: Song
authors.affiliation: a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , P.R. China.|b School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing , P.R. China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Ren
authors.affiliation: c Institute of Plant and Environment Protection , Beijing Academy of Agriculture and Forestry Sciences , Beijing , P.R. China.
authors.forename: Dan
authors.initials: D
authors.lastname: Dong
authors.affiliation: a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , P.R. China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Zheng
authors.affiliation: c Institute of Plant and Environment Protection , Beijing Academy of Agriculture and Forestry Sciences , Beijing , P.R. China.
authors.forename: Ting
authors.initials: T
authors.lastname: Liu
authors.affiliation: a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , P.R. China.
authors.forename: Yun-Fang
authors.initials: YF
authors.lastname: Zhao
authors.affiliation: a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , P.R. China.
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Tu
authors.affiliation: a Modern Research Center for Traditional Chinese Medicine , Beijing University of Chinese Medicine , Beijing , P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
mesh_terms: D000893:Anti-Inflammatory Agents / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D008070:Lipopolysaccharides / Q000494:pharmacology; D017628:Microglia / Q000187:drug effects; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D010407:Penicillium / Q000378:metabolism*
chemical_list: D000893:Anti-Inflammatory Agents; D008070:Lipopolysaccharides; D009569:Nitric Oxide
keywords: Penicillium purpurogenum; anti-neuroinflammatory activity; coumarin; dihydroisocoumarin