title: Concise Synthesis of Astellatol Core Skeleton.
abstract: A ten-step, enantiospecific synthesis of the highly challenging core skeleton of sesterterpenoid astellatol has been achieved. Key transformations of this strategy include a facile, convergent construction of the tricyclic motif and a SmI2 -induced reductive radical cyclization that forms the pivotal cyclobutane ring.
authors.affiliation: South University of Science and Technology of China, Department of Chemistry, No. 1088 Xueyuan Ave., Nanshan District, Shenzhen, Guangdong, 518055, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Zhao
authors.affiliation: South University of Science and Technology of China, Department of Chemistry, No. 1088 Xueyuan Ave., Nanshan District, Shenzhen, Guangdong, 518055, China.
authors.forename: Shengling
authors.initials: S
authors.lastname: Xie
authors.affiliation: South University of Science and Technology of China, Department of Chemistry, No. 1088 Xueyuan Ave., Nanshan District, Shenzhen, Guangdong, 518055, China.
authors.forename: Gui
authors.initials: G
authors.lastname: Chen
authors.affiliation: South University of Science and Technology of China, Department of Chemistry, No. 1088 Xueyuan Ave., Nanshan District, Shenzhen, Guangdong, 518055, China. xuj@sustc.edu.cn.
authors.forename: Jing
authors.identifier: http://orcid.org/0000-0002-5304-7350
authors.initials: J
authors.lastname: Xu
mesh_terms: D002384:Catalysis; D003500:Cyclization; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D012717:Sesquiterpenes; C000607399:astellatol
keywords: natural products; radical reaction; sesterterpenoids; terpenes; total synthesis