title: Epileptic seizure in primary intracranial sarcoma: a case report and literature review.
abstract: OBJECTIVE
  The aim of this study is to describe epileptic seizures in patients with primary intracranial sarcomas.
  
  
  METHODS
  We report a 17-year-old girl diagnosed with primary high-grade intracranial sarcoma with initial clinical manifestation of nonconvulsive status epilepticus. Literature reports between 2000 and 2014, relevant to primary intracranial sarcomas in children, were reviewed. The clinical presentations and neurological outcomes were analyzed.
  
  
  RESULTS
  Eleven of 29cases (38 %), 8 males and 3 females, who exhibited epileptic seizures as one of the initial symptoms and diagnosed with primary intracranial sarcomas were collected. The median age of disease onset was 5 years. The two most common seizure types were generalized seizures (45 %) and status epilepticus (36 %). Nine of 11 patients (82 %) had tumor growth involving the frontal lobe. Nine cases had the median duration of follow-up 1.7 years, of which 6 cases showed tumor recurrence and 3 cases died during the period of follow-up.
  
  
  CONCLUSIONS
  Epileptic seizures as one of the clinical manifestations are uncommon. The two most common seizure types were generalized seizures and status epilepticus. The most frequent location of primary intracranial sarcoma-related seizures was the frontal lobe. The clinical outcome varied.
authors.affiliation: Department of Pediatrics, Taichung Veterans General Hospital, 1650, Taiwan Boulevard Sec. 4, Taichung, 407, Taiwan.
authors.forename: Yen-Ping
authors.initials: YP
authors.lastname: Chen
authors.affiliation: Department of Pediatrics, Taichung Veterans General Hospital, 1650, Taiwan Boulevard Sec. 4, Taichung, 407, Taiwan. leehf@hotmail.com.tw.|School of Medicine, Chung Shan Medical University, Taichung, Taiwan. leehf@hotmail.com.tw.
authors.forename: Hsiu-Fen
authors.initials: HF
authors.lastname: Lee
authors.affiliation: Department of Pediatric Neurosurgery, Division of Neurosurgery, Taipei Medical University Hospital, Taipei, Taiwan.
authors.forename: Tai-Tong
authors.initials: TT
authors.lastname: Wong
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000150:complications / Q000000981:diagnostic imaging* / Q000601:surgery*; D004827:Epilepsy / Q000000981:diagnostic imaging* / Q000209:etiology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D012509:Sarcoma / Q000150:complications / Q000000981:diagnostic imaging* / Q000601:surgery*
keywords: Child; Clinical manifestations; Clinical outcomes; Epileptic seizures; Intracranial sarcoma