title: Synthesis of Unnatural 2-Substituted Quinolones and 1,3-Diketones by a Member of Type III Polyketide Synthases from Huperzia serrata.
abstract: A curcuminoids, benzalacetone-, and quinolone-producing type III polyketide synthase (HsPKS3) from Huperzia serrata uniquely catalyzes the formation of unnatural 2-substituted quinolones and 1,3-diketones via head-to-head condensation of two completely different substrates. The broad range of substrate tolerance of HsPKS3 facilitates accessing structurally diverse 2-substituted quinolones and 1,3-diketones.
authors.affiliation: Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine , Beijing 100029, China.|School of Chinese Materia Medica, Beijing University of Chinese Medicine , Beijing 100102, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Wang
authors.affiliation: Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine , Beijing 100029, China.
authors.forename: Xiao-Hui
authors.initials: XH
authors.lastname: Wang
authors.affiliation: Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine , Beijing 100029, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Liu
authors.affiliation: Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine , Beijing 100029, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine , Beijing 100029, China.|School of Chinese Materia Medica, Beijing University of Chinese Medicine , Beijing 100102, China.
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Shi
authors.affiliation: Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine , Beijing 100029, China.
authors.forename: Yue-Lin
authors.initials: YL
authors.lastname: Song
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, Peking University , Beijing 100191, China.
authors.forename: Ke-Wu
authors.initials: KW
authors.lastname: Zeng
authors.affiliation: Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine , Beijing 100029, China.|School of Chinese Materia Medica, Beijing University of Chinese Medicine , Beijing 100102, China.
authors.forename: Le
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine , Beijing 100029, China.
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Tu
authors.affiliation: Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine , Beijing 100029, China.
authors.forename: She-Po
authors.initials: SP
authors.lastname: Shi
mesh_terms: D055162:Biocatalysis; D003500:Cyclization; D032501:Huperzia / Q000201:enzymology; D007659:Ketones / Q000138:chemical synthesis* / Q000302:isolation & purification; D010940:Plant Proteins / Q000737:chemistry*; D048630:Polyketide Synthases / Q000737:chemistry*; D015363:Quinolones / Q000138:chemical synthesis* / Q000302:isolation & purification
chemical_list: D007659:Ketones; D010940:Plant Proteins; D015363:Quinolones; D048630:Polyketide Synthases