title: Painless Jaundice Caused by Clonorchis sinensis Infection: A Case Report.
abstract: A man with only yellowing of the skin and eye sclera was diagnosed with clonorchiasis, which rarely manifested jaundice as the initial symptom. However, because of a lack of evidence for a diagnostic gold standard, the time until definitive diagnosis was more than a week. The diagnostic process relied on inquiring about the patient's history, including the place of residence, dietary habits, and symptoms, as well as on serological findings, an imaging examination, and pathological findings. MRCP and CT results showed mild dilatation of intrahepatic ducts and increased periductal echogenicity. The eggs were ultimately found in stool by water sedimentation method after the negative report through direct smear. DNA sequencing of PCR production of the eggs demonstrated 98-100% homology with ITS2 of Clonorchis sinensis. After anti-parasite medical treatment, the patient's symptoms were gradually relieved. Throughout the diagnostic procedure, besides routine examinations, the sedimentation method or concentration method could be used as a sensitive way for both light and heavy C. sinensis infection in the definite diagnosis.
authors.affiliation: Infection Department, the First Hospital of Jilin University, Changchun 130021, Jilin, P. R. China.
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Hao
authors.affiliation: Infection Department, the First Hospital of Jilin University, Changchun 130021, Jilin, P. R. China.
authors.forename: Wanguo
authors.initials: W
authors.lastname: Bao
authors.affiliation: Infection Department, the First Hospital of Jilin University, Changchun 130021, Jilin, P. R. China.
authors.forename: Meishan
authors.initials: M
authors.lastname: Jin
authors.affiliation: Infection Department, the First Hospital of Jilin University, Changchun 130021, Jilin, P. R. China.
authors.forename: Yuxiang
authors.initials: Y
authors.lastname: Li
authors.affiliation: Infection Department, the First Hospital of Jilin University, Changchun 130021, Jilin, P. R. China.
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use; D001706:Biopsy; D003003:Clonorchiasis / Q000175:diagnosis* / Q000188:drug therapy / Q000469:parasitology / Q000473:pathology*; D003004:Clonorchis sinensis / Q000302:isolation & purification*; D016000:Cluster Analysis; D018509:DNA, Helminth / Q000737:chemistry / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000737:chemistry / Q000235:genetics; D003955:Diagnostic Tests, Routine; D005243:Feces / Q000469:parasitology; D006651:Histocytochemistry; D006801:Humans; D007565:Jaundice / Q000209:etiology* / Q000469:parasitology / Q000473:pathology*; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008853:Microscopy; D008875:Middle Aged; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000871:Anthelmintics; D018509:DNA, Helminth; D021903:DNA, Ribosomal Spacer
keywords: Clonorchis sinensis; PCR; image; painless jaundice; sedimentation method