title: Prenatal maternal depression and child serotonin transporter linked polymorphic region (5-HTTLPR) and dopamine receptor D4 (DRD4) genotype predict negative emotionality from 3 to 36 months.
abstract: Prenatal maternal depression and a multilocus genetic profile of two susceptibility genes implicated in the stress response were examined in an interaction model predicting negative emotionality in the first 3 years. In 179 mother-infant dyads from the Maternal Adversity, Vulnerability, and Neurodevelopment cohort, prenatal depression (Center for Epidemiologic Studies Depressions Scale) was assessed at 24 to 36 weeks. The multilocus genetic profile score consisted of the number of susceptibility alleles from the serotonin transporter linked polymorphic region gene (5-HTTLPR): no long-rs25531(A) (LA: short/short, short/long-rs25531(G) [LG], or LG/LG] vs. any LA) and the dopamine receptor D4 gene (six to eight repeats vs. two to five repeats). Negative emotionality was extracted from the Infant Behaviour Questionnaire-Revised at 3 and 6 months and the Early Child Behavior Questionnaire at 18 and 36 months. Mixed and confirmatory regression analyses indicated that prenatal depression and the multilocus genetic profile interacted to predict negative emotionality from 3 to 36 months. The results were characterized by a differential susceptibility model at 3 and 6 months and by a diathesis-stress model at 36 months.
authors.affiliation: McGill University.
authors.forename: Cathryn Gordon
authors.initials: CG
authors.lastname: Green
authors.affiliation: McGill University.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Babineau
authors.affiliation: Jewish General Hospital.
authors.forename: Alexia
authors.initials: A
authors.lastname: Jolicoeur-Martineau
authors.affiliation: McGill University.
authors.forename: Andrée-Anne
authors.initials: AA
authors.lastname: Bouvette-Turcot
authors.affiliation: McGill University.
authors.forename: Klaus
authors.initials: K
authors.lastname: Minde
authors.affiliation: St.-Joseph's Healthcare Hamilton and McMaster University.
authors.forename: Roberto
authors.initials: R
authors.lastname: Sassi
authors.affiliation: CHU Sainte-Justine.
authors.forename: Martin
authors.initials: M
authors.lastname: St-André
authors.affiliation: Dalhousie University.
authors.forename: Normand
authors.initials: N
authors.lastname: Carrey
authors.affiliation: Ryerson University.
authors.forename: Leslie
authors.initials: L
authors.lastname: Atkinson
authors.affiliation: Center for Addiction and Mental Health.
authors.forename: James L
authors.initials: JL
authors.lastname: Kennedy
authors.affiliation: St.-Joseph's Healthcare Hamilton and McMaster University.
authors.forename: Meir
authors.initials: M
authors.lastname: Steiner
authors.affiliation: McGill University.
authors.forename: John
authors.initials: J
authors.lastname: Lydon
authors.affiliation: Ludmer Centre for Neuroinformatics and Mental Health.
authors.forename: Helene
authors.initials: H
authors.lastname: Gaudreau
authors.affiliation: McGill University.
authors.forename: Jacob A
authors.initials: JA
authors.lastname: Burack
authors.affiliation: Center for Addiction and Mental Health.
authors.forename: Robert
authors.initials: R
authors.lastname: Levitan
authors.affiliation: McGill University.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Meaney
authors.affiliation: McGill University.
authors.forename: Ashley
authors.initials: A
authors.lastname: Wazana
mesh_terms: D000328:Adult; D000483:Alleles; D002675:Child, Preschool; D015331:Cohort Studies; D003863:Depression / Q000523:psychology*; D004644:Emotions / Q000502:physiology*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007223:Infant; D018730:Infant Behavior / Q000523:psychology*; D008297:Male; D008962:Models, Theoretical; D009035:Mothers; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011248:Pregnancy Complications / Q000523:psychology*; D011297:Prenatal Exposure Delayed Effects / Q000523:psychology*; D050638:Receptors, Dopamine D4 / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
chemical_list: C493599:DRD4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D050638:Receptors, Dopamine D4