title: Contribution of Delta-Opioid Receptors to Pathophysiological Events Explored by Endogenous Enkephalins.
abstract: Very few discoveries in the neurosciences have triggered clinical speculation and experimentation regarding the etiology of psychiatric illness to the same extent as that following identification of the opiate receptor(s) and subsequent isolation of endogenous morphine-like peptides. There is overwhelming evidence in animals and in human that opioids are involved in behaviorally relevant issues such as the modulation of pain, the response to stress, motivation, addiction, sexuality, food intake, etc., but our knowledge on the possible relation between opioids and mental illness is still very limited.These responses could be explored eitheir by using higlhy selective delta agonist or by emphasizing the effects of phasically secreted endogenous opioid peptides, enkephalin. Both approaches were investigated in particular through protection of enkephalin degradation by dual enkephalinase ihibitors DENKIs such as RB101, PL37 or PL265.
authors.affiliation: Membre de l'Académie des Sciences (France et Europe), U1022 INSERM/UMR 8258 CNRS, Université Paris-Descartes (Paris V), CSO Pharmaleads SAS, 4 Avenue de l'Observatoire, 75006, Paris, France. bernard.roques@parisdescartes.fr.
authors.forename: Bernard P
authors.initials: BP
authors.lastname: Roques
mesh_terms: D000818:Animals; D004745:Enkephalins / Q000502:physiology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy / Q000503:physiopathology; D015260:Neprilysin / Q000037:antagonists & inhibitors*; D010146:Pain / Q000188:drug therapy / Q000503:physiopathology; D017465:Receptors, Opioid, delta / Q000187:drug effects*
chemical_list: D004745:Enkephalins; D004791:Enzyme Inhibitors; D017465:Receptors, Opioid, delta; D015260:Neprilysin
keywords: Aminopeptidase inhibition; DENKIs, Dual enkephalinase inhibitor; Depression; Dopamine; Endogenous opioids peptides; Enkephalin; Enkephalinases; Synthetic opioids