title: Chronic Rhinosinusitis and Aspirin-Exacerbated Respiratory Disease.
abstract: Patients with severe asthma and concomitant chronic rhinosinusitis often have severe, refractory upper and lower airway inflammation. This inflammation has been proposed to be similar throughout the upper and lower airways leading to the unified airways concept. This article reviews chronic rhinosinusitis with and without nasal polyps, and the subgroup with aspirin-exacerbated respiratory disease, while focusing on the relationship with asthma. Additionally, diagnosis and treatment with current and newer therapies are discussed.
authors.affiliation: Department of Allergy and Immunology, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA.
authors.forename: Neha M
authors.initials: NM
authors.lastname: Dunn
authors.affiliation: Department of Allergy and Immunology, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA. Electronic address: katialr@njhealth.org.
authors.forename: Rohit K
authors.initials: RK
authors.lastname: Katial
mesh_terms: D000485:Allergens / Q000276:immunology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D001241:Aspirin / Q000009:adverse effects*; D001249:Asthma / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D002908:Chronic Disease; D018450:Disease Progression; D006801:Humans; D012220:Rhinitis / Q000150:complications* / Q000175:diagnosis / Q000276:immunology / Q000382:microbiology; D012852:Sinusitis / Q000150:complications* / Q000175:diagnosis / Q000276:immunology / Q000382:microbiology
chemical_list: D000485:Allergens; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin
keywords: Aspirin-exacerbated respiratory disease; Asthma; Chronic rhinosinusitis; Chronic sinusitis; Nasal polyps