title: Variations in genes involved in fat metabolism and their association with ultrasonic and carcass traits in Japanese Black steers.
abstract: Polymorphisms in genes involved in lipid metabolism have been reported to be associated with fatty acid composition of adipose tissue. However, the relationship of these polymorphisms with premortem ultrasonic traits is unknown. The objective of this study, therefore, was to assess the association between polymorphisms in fatty acid synthase, stearoyl-coenzyme A desaturase (SCD), sterol regulatory element-binding protein 1 (SREBP1), diacylglycerol acyltransferase 1, and nuclear receptor subfamily 1, group H, number 3 genes with ultrasonic and carcass traits in Japanese Black steers (n = 300) under progeny testing at the Livestock Improvement Association of Miyazaki. To have a comprehensive analysis of the association between the aforementioned genetic polymorphisms and ultrasonic traits, longitudinal measurements of ultrasonic traits were taken. Furthermore, the association of these genetic polymorphisms and carcass traits was evaluated. The polymorphisms in the SCD gene and SREBP1 were associated (P < 0.05) with some ultrasonic traits at multiple stages. To add to that, the polymorphisms were associated (P < 0.05) with some carcass traits. These findings suggest that the polymorphisms in SCD and SREBP1 are functional mutations or could be related to mutations that can aid in selection to improve some ultrasonic and carcass traits.
authors.affiliation: Interdisciplinary Graduate School of Agriculture and Engineering, University of Miyazaki, Miyazaki, Japan.
authors.forename: Fortune N
authors.initials: FN
authors.lastname: Jomane
authors.affiliation: Department of Animal and Grassland Sciences, University of Miyazaki, Miyazaki, Japan.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Ishida
authors.affiliation: Department of Animal and Grassland Sciences, University of Miyazaki, Miyazaki, Japan.
authors.forename: Tadaaki
authors.initials: T
authors.lastname: Tokunaga
authors.affiliation: Department of Animal and Grassland Sciences, University of Miyazaki, Miyazaki, Japan.
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Morita
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D002417:Cattle / Q000235:genetics* / Q000378:metabolism*; D054890:Fatty Acid Synthase, Type I / Q000235:genetics*; D056726:Genetic Association Studies; D050356:Lipid Metabolism / Q000235:genetics*; D008297:Male; D018482:Muscle, Skeletal / Q000033:anatomy & histology / Q000000981:diagnostic imaging* / Q000378:metabolism; D009154:Mutation; D011110:Polymorphism, Genetic; D019655:Quantitative Trait, Heritable; D013230:Stearoyl-CoA Desaturase / Q000235:genetics; D051780:Sterol Regulatory Element Binding Protein 1 / Q000235:genetics; D014463:Ultrasonography
chemical_list: D051780:Sterol Regulatory Element Binding Protein 1; D013230:Stearoyl-CoA Desaturase; D054890:Fatty Acid Synthase, Type I
keywords: Japanese Black steer; carcass ability; polymorphisms; ultrasound