title: Abnormal organization of white matter networks in patients with subjective cognitive decline and mild cognitive impairment.
abstract: Network analysis has been widely used in studying Alzheimer's disease (AD). However, how the white matter network changes in cognitive impaired patients with subjective cognitive decline (SCD) (a symptom emerging during early stage of AD) and amnestic mild cognitive impairment (aMCI) (a pre-dementia stage of AD) is still unclear. Here, structural networks were constructed respectively based on FA and FN for 36 normal controls, 21 SCD patients, and 33 aMCI patients by diffusion tensor imaging and graph theory. Significantly lower efficiency was found in aMCI patients than normal controls (NC). Though not significant, the values in those with SCD were intermediate between aMCI and NC. In addition, our results showed significantly altered betweenness centrality located in right precuneus, calcarine, putamen, and left anterior cingulate in aMCI patients. Furthermore, association was found between network metrics and cognitive impairment. Our study suggests that the structural network properties might be preserved in SCD stage and disrupted in aMCI stage, which may provide novel insights into pathological mechanisms of AD.
authors.affiliation: Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, China.
authors.forename: Xiao-Ni
authors.initials: XN
authors.lastname: Wang
authors.affiliation: School of Life Science, Beijing Institute of Technology, Beijing, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zeng
authors.affiliation: Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, China.
authors.forename: Guan-Qun
authors.initials: GQ
authors.lastname: Chen
authors.affiliation: School of Life Science, Beijing Institute of Technology, Beijing, China.
authors.forename: Yi-He
authors.initials: YH
authors.lastname: Zhang
authors.affiliation: Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, China.
authors.forename: Xuan-Yu
authors.initials: XY
authors.lastname: Li
authors.affiliation: School of Life Science, Beijing Institute of Technology, Beijing, China.
authors.forename: Xu-Yang
authors.initials: XY
authors.lastname: Hao
authors.affiliation: Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yu
authors.affiliation: School of Life Science, Beijing Institute of Technology, Beijing, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, China.
authors.forename: Can
authors.initials: C
authors.lastname: Sheng
authors.affiliation: Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, China.
authors.forename: Yu-Xia
authors.initials: YX
authors.lastname: Li
authors.affiliation: Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, China.
authors.forename: Hong-Yan
authors.initials: HY
authors.lastname: Li
authors.affiliation: Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Song
authors.affiliation: Department of Radiology, XuanWu Hospital of Capital Medical University, Beijing, China.
authors.forename: Kun-Cheng
authors.initials: KC
authors.lastname: Li
authors.affiliation: School of Life Science, Beijing Institute of Technology, Beijing, China.
authors.forename: Tian-Yi
authors.initials: TY
authors.lastname: Yan
authors.affiliation: School of Life Science, Beijing Institute of Technology, Beijing, China.
authors.forename: Xiao-Ying
authors.initials: XY
authors.lastname: Tang
authors.affiliation: Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, China.|Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Han
mesh_terms: D000368:Aged; D001931:Brain Mapping; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000473:pathology*; D060825:Cognitive Dysfunction / Q000473:pathology*; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D066127:White Matter / Q000473:pathology*
keywords: Pathology Section; amnestic mild cognitive impairment; diffusion tensor imaging; network; subjective cognitive decline; white matter