title: Vitamin D Status Is Negatively Correlated with Insulin Resistance in Chinese Type 2 Diabetes.
abstract: Objectives. Vitamin D deficiency plays a role in insulin resistance and the pathogenesis of type 2 diabetes mellitus. Little information is available about the association between vitamin D status and insulin resistance in the Chinese population. Currently, vitamin D status is evaluated by the concentrations of serum 25-hydroxyvitamin D [25(OH)D]. This study explores the relationship between insulin resistance and serum 25-hydroxyvitamin D concentrations in Chinese patients with type 2 diabetes mellitus. Subjects and Methods. This study included 117 patients with type 2 diabetes. The following variables were measured: 25-hydroxyvitamin D [25(OH)D], glycosylated hemoglobin A1c (HbA1c), fasting blood glucose (FBS), fasting blood insulin (FINS), fasting blood C-peptide, serum creatinine (SCr), glomerular filtration rate (eGFR), body mass index (BMI), and homeostatic model estimates of insulin resistance (HOMA-IR). Results. The cases were divided into three groups: Group 1 (G1) with 25(OH)D ≤ 20 ng/mL [≤50 nmol/L], Group 2 (G2) with 25(OH)D values from 20 ng/mL [50 nmol/L] to 30 ng/mL [75 nmol/L], and Group 3 (G3) with 25(OH)D ≥ 30 ng/mL [≥75 nmol/L], with 52.6%, 26.3%, and 21.1% of subjects in Groups 1-3, respectively. There was a negative correlation between 25(OH)D and HOMA-IR (β = -0.314, p = 0.001) adjusted by age, BMI, and eGFR. Conclusion. Better vitamin D status may be protective of glucose homeostasis since 25(OH)D was negatively associated with insulin resistance in Chinese patients with type 2 diabetes.
authors.affiliation: Department of Endocrinology & Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China; Xiamen Second Hospital affiliated Xiamen Medical College, Xiamen 361021, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Xiamen Second Hospital affiliated Xiamen Medical College, Xiamen 361021, China.
authors.forename: Jianhong
authors.initials: J
authors.lastname: Ye
authors.affiliation: Xiamen Second Hospital affiliated Xiamen Medical College, Xiamen 361021, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Guo
authors.affiliation: Sanming City Hospital of Integrated Traditional Chinese and Western Medicine, Sanming 365000, China.
authors.forename: Zhenhao
authors.initials: Z
authors.lastname: Lan
authors.affiliation: Department of Endocrinology, The Second Hospital of Shanxi Medical University, Taiyuan 030001, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Li
authors.affiliation: Xiamen Second Hospital affiliated Xiamen Medical College, Xiamen 361021, China.
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Pan
authors.affiliation: Xiamen Second Hospital affiliated Xiamen Medical College, Xiamen 361021, China.
authors.forename: Xianming
authors.initials: X
authors.lastname: Rao
authors.affiliation: Department of Endocrinology & Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
authors.forename: Zongji
authors.identifier: 0000-0003-1356-4780
authors.initials: Z
authors.lastname: Zheng
authors.affiliation: Xiamen Second Hospital affiliated Xiamen Medical College, Xiamen 361021, China.
authors.forename: Fangtao
authors.initials: F
authors.lastname: Luo
authors.affiliation: Xiamen Second Hospital affiliated Xiamen Medical College, Xiamen 361021, China.
authors.forename: Luping
authors.initials: L
authors.lastname: Lin
authors.affiliation: Xiamen Second Hospital affiliated Xiamen Medical College, Xiamen 361021, China.
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Lin
authors.affiliation: Department of Endocrinology & Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
authors.forename: Yaoming
authors.initials: Y
authors.lastname: Xue