title: [Evaluation of repetitive transcranial magnetic stimulation effectiveness in treatment of psychiatric and neurologic diseases].
abstract: Repetitive transcranial magnetic stimulation (rTMS) is a treatment option with proved effectiveness especially in drug resist depression. It is used in functional brain mapping before neurosurgery operations and diagnostic of corticospinal tract transmission. Many studies are performed to evaluate rTMS using in treatment of obsessive - compulsive disorder, schizophrenia, autism, strokes, tinnitus, Alzheimer and Parkinson diseases, cranial traumas. Moreover rTMS was used in treatment of multiple sclerosis, migraine, dystonia. Electromagnetical field generated by rTMS penetrate skin of the scalp and infiltrate brain tissues to a depth of 2 cm, cause neurons depolarization and generating motor, cognitive and affective effects. Depending on the stimulation frequency rTMS can stimuli or inhibit brain cortex. rTMS mechanism of action remains elusive. Probably it is connected with enhancement of neurotransmitters, modulation of signals transductions pathways in Central Nervous System, gene transcription and release of neuroprotective substances. Studies with use of animals revealed that rTMS stimulation can generate brain changes similar to those seen after electric shock therapy without provoking seizures. The aim of presenting study was to analyze actual researches evaluating rTMS use in treatment of psychiatric and neurological diseases.
authors.affiliation: Department of Neurology, Central Clinical Hospital of the Ministry of National Defense, Military Institute of Medicine in Warsaw, Poland.
authors.forename: Żanna
authors.initials: Ż
authors.lastname: Pastuszak
authors.affiliation: Department of Neurology, Central Clinical Hospital of the Ministry of National Defense, Military Institute of Medicine in Warsaw, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Stępień
authors.affiliation: Department of Neurology, Central Clinical Hospital of the Ministry of National Defense, Military Institute of Medicine in Warsaw, Poland.
authors.forename: Renata
authors.initials: R
authors.lastname: Piusińska-Macoch
authors.affiliation: Department of Neurology, Central Clinical Hospital of the Ministry of National Defense, Military Institute of Medicine in Warsaw, Poland.
authors.forename: Bogdan
authors.initials: B
authors.lastname: Brodacki
authors.affiliation: Department of Neurology, Central Clinical Hospital of the Ministry of National Defense, Military Institute of Medicine in Warsaw, Poland.
authors.forename: Kazimierz
authors.initials: K
authors.lastname: Tomczykiewicz
mesh_terms: D001921:Brain; D006801:Humans; D001523:Mental Disorders / Q000628:therapy*; D009422:Nervous System Diseases / Q000175:diagnosis / Q000628:therapy*; D050781:Transcranial Magnetic Stimulation; D016896:Treatment Outcome
keywords: Parkinson disease; autism; depression; transcranial magnetic stimulation