title: Primary angiosarcoma of neck nodes with bony metastasis - A case report.
abstract: This is a case of a 30 year old female who presented in February 2012 with a large painless left neck swelling since 5 months. Her biopsy was done but the result was inconclusive. Later on after proper staging workup it was found to be bony metastatic disease. Her repeated biopsy showed spindle cell lesion. She was advised surgery, which was done revealing poorly differentiated angiosarcoma involving 27 out of 33 lymph nodes. Angiosarcoma is an uncommon malignant neoplasm characterized by rapidly proliferating, extensively infiltrating anaplastic cells derived from blood vessels and lining irregular blood-filled spaces. Cutaneous angiosarcoma of the scalp and face is the most common form of angiosarcoma. Angiosarcoma of the cervical lymph node without a primary scalp or oral cavity lesion is a very rare presentation and has been reported only once. Thus, this case reported with bony metastasis can be labeled as the first of its kind.
authors.affiliation: Department of Radiotherapy, Ziauddin University Hospital, Karachi.
authors.forename: Shabbir Hussain
authors.initials: SH
authors.lastname: Ashiq Ali
authors.affiliation: Department of Radiotherapy, Ziauddin University Hospital, Karachi.
authors.forename: Mohammad Jawaid
authors.initials: MJ
authors.lastname: Akhtar Mallick
authors.affiliation: Department of Radiotherapy, Ziauddin University Hospital, Karachi.
authors.forename: Ayesha
authors.initials: A
authors.lastname: Javed
authors.affiliation: Department of Radiotherapy, Ziauddin University Hospital, Karachi.
authors.forename: Abdul Hafeez
authors.initials: AH
authors.lastname: Lakhan
mesh_terms: D000328:Adult; D001706:Biopsy / Q000379:methods; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D003937:Diagnosis, Differential; D005260:Female; D006394:Hemangiosarcoma / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000473:pathology / Q000601:surgery; D009333:Neck; D037981:Neck Dissection / Q000379:methods*; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography / Q000379:methods; D019043:Vascular Neoplasms / Q000473:pathology / Q000503:physiopathology / Q000601:surgery
keywords: Angiosarcoma, Neck nodes, Bony metastasis, Vascular neoplasm.