title: Endomyocardial radial strain rate imaging during dobutamine stress echocardiography for the evaluation of contractile reserve in patients with dilated cardiomyopathy.
abstract: OBJECTIVE
  Myocardial contractile reserve is associated with clinical prognosis in patients with dilated cardiomyopathy (DCM). We assessed myocardial contractile reserve using tissue Doppler strain rate imaging with dobutamine stress echocardiography in DCM patients.
  
  
  METHODS
  Simultaneous echocardiography and left ventricular (LV) catheterization during dobutamine stress were performed in 20 patients with DCM, and echocardiography was performed in 31 control subjects. Dobutamine was infused at a starting dose of 5 μg/kg/min for 5 minutes and then at 10 μg/kg/min. Peak endomyocardial radial strain (ɛ) and systolic strain rate (SRsys) measured with echocardiography and the maximum first derivative of LV pressure (LV dP/dtmax) derived from catheterization were used as indices of contractility. Their percentage change from baseline to the dose of 10 μg/kg/min was calculated.
  
  
  RESULTS
  The ɛ and SRsyswere significantly smaller in DCM patients than in controls. The LV dP/dtmax, ɛ, and SRsyswere significantly higher at the dose of 10 μg/kg/min than at baseline. The percentage change in SRsyswas significantly correlated with the percentage change in LV dP/dtmax.
  
  
  CONCLUSIONS
  Strain rate imaging during dobutamine stress in DCM might prove noninvasively informative for the evaluation of myocardial contractile reserve and provide insight into LV systolic dysfunction. © 2016 Wiley Periodicals, Inc. J Clin Ultrasound 44:555-560, 2016.
authors.affiliation: Department of Pathophysiology Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Minoshima
authors.affiliation: Department of Biomedical Sciences, Chubu University Graduate School of Life and Health Sciences, Kasugai, Japan. anoda@isc.chubu.ac.jp.
authors.forename: Akiko
authors.initials: A
authors.lastname: Noda
authors.affiliation: Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Masakazu
authors.initials: M
authors.lastname: Kobayashi
authors.affiliation: Department of Sleep Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Seiko
authors.initials: S
authors.lastname: Miyata
authors.affiliation: Department of Advanced Medicine in Cardiopulmonary Disease, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Hirashiki
authors.affiliation: Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Okumura
authors.affiliation: Department of Cardiology, Banbuntane-Hotokukai Hospital, Fujita Health University, Nagoya, Japan.
authors.forename: Hideo
authors.initials: H
authors.lastname: Izawa
authors.affiliation: Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Ishii
authors.affiliation: Department of Advanced Medicine in Cardiopulmonary Disease, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Takahisa
authors.initials: T
authors.lastname: Kondo
authors.affiliation: Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Toyoaki
authors.initials: T
authors.lastname: Murohara
mesh_terms: D002311:Cardiomyopathy, Dilated / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D004280:Dobutamine / Q000008:administration & dosage*; D015150:Echocardiography, Doppler / Q000379:methods*; D025401:Echocardiography, Stress / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology*
chemical_list: D004280:Dobutamine
keywords: dilated cardiomyopathy; dobutamine stress echocardiography; myocardial contractile reserve; strain rate