title: Clinical Presentation of Inadvertent Intrathecal Vincristine Masquerading Guillain-Barre Syndrome.
abstract: Vincristine, a potent chemotherapeutic agent, is highly neurotoxic. If given intrathecally by accident it is almost always fatal. We are reporting a 6 year old girl with acute lymphoblastic leukaemia in complete remission, who was given inadvertent intrathecal Vincristine instead of Methotrexate. She developed gradually progressive quadriplegia and respiratory paralysis requiring prolonged mechanical ventilation, initially mimicking Guillain-Barre Syndrome, both clinically and electro-physiologically. She also developed progressive encephalopathy. The clinical deterioration subsequently plateaued without any significant improvement and after more than 5 months, she finally expired.
authors.affiliation: Fortis Hospital, 30/H Mahendra Roy Lane, Kolkata, West Bengal 700046 India.
authors.forename: Agni Sekhar
authors.identifier: 0000-0003-2059-0303
authors.initials: AS
authors.lastname: Saha
authors.affiliation: Institute of Child Health, Kolkata, India.
authors.forename: Md Fekarul
authors.initials: MF
authors.lastname: Islam
authors.affiliation: Institute of Child Health, Kolkata, India.
authors.forename: Sukanta
authors.initials: S
authors.lastname: Bhattacharya
authors.affiliation: Institute of Child Health, Kolkata, India.
authors.forename: Prabhas Prasun
authors.initials: PP
authors.lastname: Giri
keywords: ALL; GB syndrome; Intrathecal vincristine