title: [ANTHELMINTIC SUBSTANCES: MAIN CLASSES, PROBLEMS, TRENDS IN DEVELOPMENT AND PROSPECTS].
abstract: The review chronologically considers the main classes of the currently available anthelminthic substances: early anthelmintic compounds, benzimidazoles, imidazolthiazoles, tetrahydropyrimidines, avermectins and milbemycins, and salicylanilides. Great attention is paid to novel substances (emodepside, monepantel, derquantel, tribendimidine) and promising developments. Some aspects of the molecular mechanisms of action of anthelmintics, their resistance, and alternative dehelmintization methods are discussed.
authors.forename: M Kh
authors.initials: MKh
authors.lastname: Dzhafarov
authors.forename: F
authors.initials: F
authors.lastname: Vasilevich
authors.forename: A S
authors.initials: AS
authors.lastname: Dovgalev
authors.forename: K D
authors.initials: KD
authors.lastname: Imamkuliev
authors.forename: E A
authors.initials: EA
authors.lastname: Pautova
mesh_terms: D000607:Aminoacetonitrile / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis / Q000145:classification* / Q000494:pharmacology; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology; D002589:Cestoda / Q000187:drug effects* / Q000502:physiology; D002590:Cestode Infections / Q000175:diagnosis / Q000188:drug therapy / Q000469:parasitology; D047630:Depsipeptides / Q000138:chemical synthesis / Q000494:pharmacology; D015195:Drug Design; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis / Q000494:pharmacology; D008519:Medicine, Traditional; D009348:Nematoda / Q000187:drug effects* / Q000502:physiology; D009349:Nematode Infections / Q000175:diagnosis / Q000188:drug therapy / Q000469:parasitology; D010082:Oxepins / Q000138:chemical synthesis / Q000494:pharmacology; D010655:Phenylenediamines / Q000138:chemical synthesis / Q000494:pharmacology; D014200:Trematoda / Q000187:drug effects* / Q000502:physiology; D014201:Trematode Infections / Q000175:diagnosis / Q000188:drug therapy / Q000469:parasitology
chemical_list: D000871:Anthelmintics; D001688:Biological Products; D047630:Depsipeptides; D007211:Indoles; D010082:Oxepins; D010655:Phenylenediamines; C575297:derquantel; C056017:tribendimidine; D000607:Aminoacetonitrile; C533978:monepantel; C468987:emodepside