title: Moving the Frontiers of Cancer Chemotherapy for Solid Tumors by Changing the Scope of Drug Development.
abstract: Our increasing knowledge on the pathogenetic mechanisms involved in the growth of cancer cells and on the molecular basis of cancer has influenced the development of anticancer agents. The realization that new targets should be evaluated for anti-cancer drug treatment has a.o. led to the introduction of the taxoids and topoisomerase I inhibitors. Attacking the known targets in a more sophisticated way led to the development of drugs with increased target specificity like Tomudex and Gemcitabine. Finally, using old drugs more efficiently by using pharmacokinetic and pharmacodynamic ananlysis hold a promise for the near future.
authors.affiliation: a Dept. of Medical Oncology, Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital , Rotterdam , The Netherlands.
authors.forename: M J
authors.initials: MJ
authors.lastname: De Jonge
authors.affiliation: a Dept. of Medical Oncology, Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital , Rotterdam , The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Verweij