title: Is there a relation between pre-sarcopenia, sarcopenia, cachexia and osteoporosis in patients with ankylosing spondylitis?
abstract: Osteoporosis is a well-known complication of ankylosing spondylitis (AS). However, data about body composition modifications and muscle performance showed conflicting results. The aim of the study was to determine the prevalence and risk factors of pre-sarcopenia, sarcopenia and cachexia in patients with AS and analyze its relationship with bone loss and symptomatic and severity parameters of the disease.
  
  
  
  Sixty-seven consecutive male patients with AS (mean age of 40.9 ± 11.0 years) and 67 healthy controls were studied. Body composition and bone mineral density (BMD) scans were obtained using DXA. The fat-free mass index (FFMI; fat-free mass divided by height squared) and the percent of fat mass (%FM) were calculated. Pre-sarcopenia was defined by low skeletal muscle mass (SMI <7.25 kg/m(2)), sarcopenia by the combined presence of the two following criteria: SMI <7.25 kg/m(2) and a low muscle strength (handgrip strength <30 kg) or a low muscle performance (timed get-up-and-go test >10 s) and cachexia by a BMI <20 kg/m(2) plus 3 from the 5 following parameters: anorexia, fatigue, handgrip strength <30 kg, CRP >5 mg/l, SMI <7.25 kg/m(2).
  
  
  
  Pre-sarcopenia, sarcopenia, cachexia, and osteoporosis prevalences were (50.4, 34.3, 11.9, and 16.0) respectively. Patients had a mean 3 kg significant decrease in FFM and a 1 kg/m(2) decrease in appendicular mass vs. healthy controls. Pre-sarcopenia, sarcopenia and cachexia were significantly associated to higher BASDAI levels and low BMD.
  
  
  
  Our study showed that men with AS had a statistically significant reduction in total and appendicular lean mass that is related to higher disease activity and significantly associated to bone loss.
authors.affiliation: Rheumatology Department, Military Hospital Mohammed V, Rabat, University Mohammed V Souissi, PO Box: 1018, Rabat, Morocco. aelmaghraoui@gmail.com.
authors.forename: Abdellah
authors.identifier: 0000-0003-0668-5680
authors.initials: A
authors.lastname: El Maghraoui
authors.affiliation: Rheumatology Department, Military Hospital Mohammed V, Rabat, University Mohammed V Souissi, PO Box: 1018, Rabat, Morocco.
authors.forename: François Bertin
authors.initials: FB
authors.lastname: Ebo'o
authors.affiliation: Rheumatology Department, Military Hospital Mohammed V, Rabat, University Mohammed V Souissi, PO Box: 1018, Rabat, Morocco.
authors.forename: Siham
authors.initials: S
authors.lastname: Sadni
authors.affiliation: Rheumatology Department, Military Hospital Mohammed V, Rabat, University Mohammed V Souissi, PO Box: 1018, Rabat, Morocco.
authors.forename: Abderrahim
authors.initials: A
authors.lastname: Majjad
authors.affiliation: Rheumatology Department, Military Hospital Mohammed V, Rabat, University Mohammed V Souissi, PO Box: 1018, Rabat, Morocco.
authors.forename: Toufik
authors.initials: T
authors.lastname: Hamza
authors.affiliation: Rheumatology Department, Military Hospital Mohammed V, Rabat, University Mohammed V Souissi, PO Box: 1018, Rabat, Morocco.
authors.forename: Aziza
authors.initials: A
authors.lastname: Mounach
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D000368:Aged; D001823:Body Composition; D015992:Body Mass Index; D015519:Bone Density; D002100:Cachexia / Q000453:epidemiology* / Q000209:etiology; D018737:Hand Strength; D006801:Humans; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength; D010024:Osteoporosis / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000209:etiology; D015995:Prevalence; D012307:Risk Factors; D055948:Sarcopenia / Q000453:epidemiology* / Q000209:etiology; D013167:Spondylitis, Ankylosing / Q000150:complications*; D055815:Young Adult
keywords: Ankylosing spondylitis; Body composition; Cachexia; DXA; Osteoporosis; Sarcopenia