title: Thrombosis of pancreatic arteriovenous malformation induced by diagnostic angiography: case report.
abstract: BACKGROUND
  We report on a case of pancreatic arteriovenous malformation (PAVM) that obliterated shortly after diagnostic angiography (DSA). PAVM is a rare anomaly that presents with upper abdominal pain, signs of acute pancreatitis and massive gastrointestinal bleeding. The management of PAVM is rather complex, with complete treatment usually accomplished only by a total extirpation of the affected organ or at least its involved portion. DSA prior to treatment decisions is helpful for characterizing symptomatic PAVM, since it can clearly depict the related vascular networks. In addition, interventional therapy can be performed immediately after diagnosis.
  
  
  METHODS
  A 39-old male was admitted due to recurring upper abdominal pain that lasted several weeks. Initial examination revealed the absence of fever or jaundice, and the laboratory tests, including that for pancreatic enzymes, were unremarkable. An abdominal ultrasound (US) showed morphological and Doppler anomalies in the pancreas that were consistent with a vascular formation. A subsequent DSA depicted a medium-sized nidus, receiving blood supply from multiple origins but with no dominant artery. Coil embolization was not possible due to the small caliber of the feeding vessels. In addition, sclerotherapy was not performed so as to avoid an unnecessary wash out to the non-targeted duodenum. Consequently, the patient received no specific treatment for his symptomatic PAVM. A large increase in pancreatic enzymes was noticed shortly after the DSA procedure. Imaging follow-up by means of CT and MRI showed small amounts of peripancreatic fluid along with a limited area of intra-parenchymal necrosis, indicating necrotizing pancreatitis. In the post-angiography follow-up the patient was hemodynamically stable the entire time and was treated conservatively. The symptoms of pancreatitis improved over a few days, and the laboratory findings returned to normal ranges. Long-term follow-up by way of a contrast-enhanced CT revealed no recanalization of the thrombosed PAVM.
  
  
  CONCLUSIONS
  The factors associated with the obliteration of PAVM during or after DSA are poorly understood. In our case it may be attributed to the low flow dynamics of PAVM, as well as to the local administration of a contrast agent. Asymptomatic PAVM, as diagnosed with non-invasive imaging techniques, should not be evaluated with DSA due to the potential risk of severe complications, such as acute pancreatitis.
authors.affiliation: Institute of Physiology, Medical Faculty, University of Ljubljana, Zaloska cesta 4, 1000, Ljubljana, Slovenia. jernej.vidmar@gmail.com.|Jozef Stefan Institute, Laboratory of Magnetic Resonance Imaging, Ljubljana, Slovenia. jernej.vidmar@gmail.com.
authors.forename: Jernej
authors.initials: J
authors.lastname: Vidmar
authors.affiliation: Clinical Department of Abdominal Surgery, University Medical Centre, Ljubljana, Slovenia.
authors.forename: Mirko
authors.initials: M
authors.lastname: Omejc
authors.affiliation: Institute of Radiology, University Medical Centre, Ljubljana, Slovenia.
authors.forename: Rok
authors.initials: R
authors.lastname: Dežman
authors.affiliation: Institute of Radiology, University Medical Centre, Ljubljana, Slovenia.
authors.forename: Peter
authors.initials: P
authors.lastname: Popovič
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D000328:Adult; D000792:Angiography / Q000009:adverse effects*; D001165:Arteriovenous Malformations / Q000150:complications* / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D010179:Pancreas / Q000098:blood supply*; D010195:Pancreatitis / Q000209:etiology; D013927:Thrombosis / Q000209:etiology*
keywords: Abdominal MRI; Acute pancreatitis; Diagnostic angiography; MR cholangiopancreatography; Pancreatic arteriovenous malformation