title: Building Bridges: Biocatalytic C-C-Bond Formation toward Multifunctional Products.
abstract: Carbon-carbon bond formation is the key reaction for organic synthesis to construct the carbon framework of organic molecules. The review gives a selection of biocatalytic C-C-bond-forming reactions which have been investigated during the last 5 years and which have already been proven to be applicable for organic synthesis. In most cases, the reactions lead to products functionalized at the site of C-C-bond formation (e.g., α-hydroxy ketones, aminoalcohols, diols, 1,4-diketones, etc.) or allow to decorate aromatic and heteroaromatic molecules. Furthermore, examples for cyclization of (non)natural precursors leading to saturated carbocycles are given as well as the stereoselective cyclopropanation of olefins affording cyclopropanes. Although many tools are already available, recent research also makes it clear that nature provides an even broader set of enzymes to perform specific C-C coupling reactions. The possibilities are without limit; however, a big library of variants for different types of reactions is required to have the specific enzyme for a desired specific (stereoselective) reaction at hand.
authors.affiliation: ACIB GmbH c/o, Department of Chemistry, University of Graz , Heinrichstrasse 28, 8010 Graz, Austria.
authors.forename: Nina G
authors.initials: NG
authors.lastname: Schmidt
authors.affiliation: Department of Chemistry, Organic and Bioorganic Chemistry, University of Graz , NAWI Graz, Heinrichstrasse 28, 8010 Graz, Austria.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Eger
authors.affiliation: ACIB GmbH c/o, Department of Chemistry, University of Graz, Heinrichstrasse 28, 8010 Graz, Austria; Department of Chemistry, Organic and Bioorganic Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, 8010 Graz, Austria.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Kroutil
keywords: C−C coupling; C−C-bond formation; biocatalysis; lyases; multifunctional products; oxidases; transferases