title: Management of drug hypersensitivity in the pediatric population.
abstract: Several recent studies confirmed that drug allergy in children is over diagnosed, which is a major public health problem, and results in use of alternative drugs, increasing resistance and health costs. Areas covered: Articles in English with data on drug hypersensitivity in children were identified by searching the databases of MEDLINE (National Library of Medicine) from 1990 till 2016. Expert commentary: It is crucial to make a precise diagnosis with performing a complete allergy work-up based on carefully selected diagnostic tests depending on whether an immediate or a non-immediate reaction is suspected. The drug provocation test remains the gold standard in diagnostic drug hypersensitivity in children.
authors.affiliation: a Department of Allergology and Pulmonology , University Children's Hospital of Belgrade , Belgrade , Serbia.|b Medical Faculty University of Belgrade , Belgrade , Serbia.
authors.forename: Marina
authors.initials: M
authors.lastname: Atanaskovic-Markovic
authors.affiliation: c Department of Child and Adolescent , University Hospital of Geneva and Medical School of The University of Geneva , Geneva , Switzerland.
authors.forename: Jean-Christoph
authors.initials: JC
authors.lastname: Caubet
keywords: Allergy; children; drug hypersensitivity; drug provocation tests; immediate reactions; non-immediate reactions; non-steroidal anti-inflammatory drugs; non-β-lactam antibiotics; skin tests; β-lactam antibiotics