title: Serum Concentration of Zinc, Copper, Selenium, Manganese, and Cu/Zn Ratio in Children and Adolescents with Myopia.
abstract: The purpose of the present study was the assessment of the serum concentration of antioxidant microelements-zinc, copper, selenium, manganese, and Cu/Zn ratio in children and adolescents with myopia. Eighty-three children were examined (mean age 14.36 ± 2.49 years) with myopia. The control group was 38 persons (mean age 12.89 ± 3.84 years). Each patient had complete eye examination. The serum concentration of zinc, copper, manganese, and selenium was determined by atomic absorption spectrometry. Cu/Zn ratio, which is the indicator of the oxidative stress, was also calculated. The average serum concentration of zinc in myopic patients was significantly lower (0.865 ± 0.221 mg L-1) in comparison to the control group (1.054 ± 0.174 mg L-1). There was significantly higher Cu/Zn ratio in myopic patients (1.196 ± 0.452) in comparison to that in the control group (0.992 ± 0.203). The average serum concentration of selenium in the study group was significantly lower (40.23 ± 12.07 μg L-1) compared with that in the control group (46.00 ± 12.25 μg L-1). There were no essential differences between serum concentration of copper and manganese in the study group and the control group. Low serum concentration of zinc and selenium in myopic children may imply an association between insufficiency of these antioxidant microelements and the development of the myopia and could be the indication for zinc and selenium supplementation in the prevention of myopia. Significantly, higher Cu/Zn ratio in the study group can suggest the relationship between myopia and oxidative stress.
authors.affiliation: Department of Pediatric Ophthalmology and Strabismus, The Medical University of Bialystok Children's Clinical Hospital, Waszyngtona 17, 15-274, Bialystok, Poland. monikafedor7@gmail.com.
authors.forename: Monika
authors.initials: M
authors.lastname: Fedor
authors.affiliation: Department of Bromatology, Medical University of Bialystok, Mickiewicza 2D, 15-222, Białystok, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Socha
authors.affiliation: Department of Pediatric Ophthalmology and Strabismus, Medical University of Bialystok, Waszyngtona 17, 15-274, Bialystok, Poland.
authors.forename: Beata
authors.initials: B
authors.lastname: Urban
authors.affiliation: Department of Bromatology, Medical University of Bialystok, Mickiewicza 2D, 15-222, Białystok, Poland.
authors.forename: Jolanta
authors.initials: J
authors.lastname: Soroczyńska
authors.affiliation: Department of Pediatric Ophthalmology and Strabismus, The Medical University of Bialystok Children's Clinical Hospital, Waszyngtona 17, 15-274, Bialystok, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Matyskiela
authors.affiliation: Department of Bromatology, Medical University of Bialystok, Mickiewicza 2D, 15-222, Białystok, Poland.
authors.forename: Maria H
authors.initials: MH
authors.lastname: Borawska
authors.affiliation: Department of Pediatric Ophthalmology and Strabismus, Medical University of Bialystok, Waszyngtona 17, 15-274, Bialystok, Poland.
authors.forename: Alina
authors.initials: A
authors.lastname: Bakunowicz-Łazarczyk
mesh_terms: D000293:Adolescent; D000975:Antioxidants / Q000032:analysis; D002648:Child; D003300:Copper / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008345:Manganese / Q000097:blood*; D009216:Myopia / Q000097:blood* / Q000175:diagnosis / Q000517:prevention & control; D018384:Oxidative Stress; D012643:Selenium / Q000097:blood*; D013054:Spectrophotometry, Atomic; D014131:Trace Elements / Q000097:blood; D015032:Zinc / Q000097:blood*
chemical_list: D000975:Antioxidants; D014131:Trace Elements; D008345:Manganese; D003300:Copper; D012643:Selenium; D015032:Zinc
keywords: Myopia, Zinc, Copper, Selenium, Manganese