title: Bone and metal targeted polymeric nanoparticles (US20150125391 A1): a patent evaluation.
abstract: BACKGROUND
  Delivery of therapeutic agents to bone is crucial for the treatment of bone metastasis and other bone diseases. The present invention patent relates to bone- and metal-targeted polymeric nanoparticles for targeting delivery of therapeutic molecules to the pathological tissues in bone or the surgical metal implant-bone tissue interface.
  
  
  METHODS
  The nanoparticles for drug delivery were fabricated via the assembly of amphiphilic polymers, in which the hydrophilic outer layer was minimal to prolong the circulation time, and the hydrophobic insider core was biodegradable and loaded with therapeutic agents. Bone-targeted elements were conjugated on the nanoparticle surface to enhance their affinity to bone and/or metal implant surface.
  
  
  CONCLUSIONS
  A prolonged, sustained release of therapeutic agents was observed by using the delivery system targeting to bone. The described invention provides a bone-targeted vector to deliver diverse therapeutic agents to bone.
authors.affiliation: a Department of Orthopedic Oncology, Changzheng Hospital , The Second Military Medical University , Shanghai , P.R. China.
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.affiliation: a Department of Orthopedic Oncology, Changzheng Hospital , The Second Military Medical University , Shanghai , P.R. China.
authors.forename: Quan
authors.initials: Q
authors.lastname: Huang
authors.affiliation: b Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences , East China Normal University , Shanghai , P.R. China.
authors.forename: Changping
authors.initials: C
authors.lastname: Wang
authors.affiliation: b Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences , East China Normal University , Shanghai , P.R. China.
authors.forename: Xinyu
authors.initials: X
authors.lastname: Wang
authors.affiliation: a Department of Orthopedic Oncology, Changzheng Hospital , The Second Military Medical University , Shanghai , P.R. China.
authors.forename: Jianru
authors.initials: J
authors.lastname: Xiao
authors.affiliation: b Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences , East China Normal University , Shanghai , P.R. China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: b Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences , East China Normal University , Shanghai , P.R. China.
authors.forename: Yiyun
authors.initials: Y
authors.lastname: Cheng
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D006801:Humans; D008670:Metals / Q000737:chemistry; D053758:Nanoparticles; D010330:Patents as Topic; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D011108:Polymers / Q000737:chemistry*; D019736:Prostheses and Implants; D014018:Tissue Distribution
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008670:Metals; D004364:Pharmaceutical Preparations; D011108:Polymers
keywords: Bone targeting; bone metastases; bone-related diseases; drug delivery; polymeric nanoparticles