title: Pro- and anti-inflammatory cytokines in post-infarction left ventricular remodeling.
abstract: OBJECTIVE
  Acute myocardial infarction (MI) leads to molecular, structural, geometric and functional changes in the heart during a process known as ventricular remodeling. Myocardial infarction is followed by an inflammatory response in which pro- and anti-inflammatory cytokines play a crucial role, particularly in left ventricular remodeling. This study aimed at evaluating serum concentrations of interleukin-8 (IL8), tumor-necrosis-factor-alpha (TNFα) and interleukin-10 (IL10), pro- and anti-inflammatory cytokines, and at correlating them with left ventricular remodeling as assessed by echocardiographic parameters.
  
  
  METHODS
  In a case-control study 30 MI patients were compared with 30 healthy controls. Serum concentrations of IL8, TNFα and IL10 were measured on day 2 and day 30 post-MI by chemiluminescence immunoassay and correlated with echocardiographic parameters.
  
  
  RESULTS
  There was an increase of IL8, and TNFα together with a decrease of IL10 at both time points. IL8 was negatively correlated with the left ventricular end-diastolic diameter (LVEDD) and positively with left ventricular systolic volume. IL10 was negatively correlated with LVEDD and left atrial volume 30days post-MI.
  
  
  CONCLUSIONS
  The increase of pro-inflammatory cytokines TNFα and IL8 was accompanied by decreased anti-inflammatory IL10. This imbalance between pro- and anti-inflammatory cytokines might contribute to the progression of left ventricular remodeling and may lead to heart failure.
authors.affiliation: Genomics Platform, Pasteur Institute of Tunis, Tunis, Tunisia.
authors.forename: S
authors.initials: S
authors.lastname: Zarrouk-Mahjoub
authors.affiliation: Genomics Platform, Pasteur Institute of Tunis, Tunis, Tunisia.
authors.forename: M
authors.initials: M
authors.lastname: Zaghdoudi
authors.affiliation: Hopital la Rabta de Tunis, Tunis, Tunisia.
authors.forename: Z
authors.initials: Z
authors.lastname: Amira
authors.affiliation: Genomics Platform, Pasteur Institute of Tunis, Tunis, Tunisia.
authors.forename: H
authors.initials: H
authors.lastname: Chebi
authors.affiliation: Genomics Platform, Pasteur Institute of Tunis, Tunis, Tunisia.
authors.forename: N
authors.initials: N
authors.lastname: Khabouchi
authors.affiliation: Krankenanstalt Rudolfstiftung, Vienna, Austria. Electronic address: fifigs1@yahoo.de.
authors.forename: J
authors.initials: J
authors.lastname: Finsterer
authors.affiliation: Hopital la Rabta de Tunis, Tunis, Tunisia.
authors.forename: R
authors.initials: R
authors.lastname: Mechmeche
authors.affiliation: Hopital militaire des Tunis, Tunis, Tunisia.
authors.forename: E
authors.initials: E
authors.lastname: Ghazouani
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D004452:Echocardiography; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000000981:diagnostic imaging*; D020257:Ventricular Remodeling / Q000502:physiology*
chemical_list: D015415:Biomarkers; D016207:Cytokines; D018836:Inflammation Mediators
keywords: Cytokines; Echocardiography; Inflammatory response; Myocardial infarction; Myocardial remodeling