title: 25 Years of Cell Cycle Research: What's Ahead?
abstract: We have reached 25 years since the first molecular approaches to plant cell cycle. Fortunately, we have witnessed an enormous advance in this field that has benefited from using complementary approaches including molecular, cellular, genetic and genomic resources. These studies have also branched and demonstrated the functional relevance of cell cycle regulators for virtually every aspect of plant life. The question is - where are we heading? I review here the latest developments in the field and briefly elaborate on how new technological advances should contribute to novel approaches that will benefit the plant cell cycle field. Understanding how the cell division cycle is integrated at the organismal level is perhaps one of the major challenges.
authors.affiliation: Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid (UAM), Nicolas Cabrera 1, 28049 Madrid, Spain. Electronic address: cgutierrez@cbm.csic.es.
authors.forename: Crisanto
authors.initials: C
authors.lastname: Gutierrez
mesh_terms: D035843:Biomedical Research / Q000266:history / Q000639:trends*; D002453:Cell Cycle / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D019070:Cell Lineage / Q000502:physiology; D002843:Chromatin / Q000502:physiology; D049673:History, 20th Century; D049674:History, 21st Century; D018521:Plant Physiological Phenomena; D010944:Plants
chemical_list: D002843:Chromatin
keywords: Arabidopsis; DNA damage; DNA replication; cell cycle; cell division; cell fate; chromatin; endoreplication; plant.