title: Preoperative statin use is not associated with improvement in survival after glioblastoma surgery.
abstract: Cohort studies have suggested that the use of statins is associated with decreased risk of glioma formation and mortality. Here, a cohort of patients with glioblastoma multiforme (GBM) was analyzed to further investigate associations between preoperative use of statins and recurrence, and progression free and overall survival. Patients who had surgery for GBM (N=284) were followed up for a median of 18.1months. Seventy-eight patients were taking statins preoperatively while the rest were not. Cox proportional hazards models adjusted for several covariates of interest were applied before and after propensity score matching. Compared with statin users, those not taking the lipid-lowering drugs had similar progression free survival before (hazard ratio [HR] 0.94, 95% confidence interval [CI] 0.70-1.26; p=0.68) and after propensity score matching (HR 0.95, 95% CI 0.67-1.35; p=0.68). Mortality was similar between both groups of patients before (HR 0.94, 95% CI 0.70-1.22; p= 0.73) and after propensity score matching (HR 1.13, 95% CI 0.78-1.64; p=0.49). Age and dexamethasone use were independent prognostic factors of survival. Contrary to previously published evidence, this study could not find an association between preoperative statin use and longer survival in GBM patients. Due to the small number of patients and retrospective nature of the study, further work is needed to understand the role of perioperative statins in GBM patients.
authors.affiliation: Department of Anesthesiology and Perioperative Medicine, The University of Texas - MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
authors.forename: S
authors.initials: S
authors.lastname: Bhavsar
authors.affiliation: Department of Anesthesiology and Perioperative Medicine, The University of Texas - MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
authors.forename: K
authors.initials: K
authors.lastname: Hagan
authors.affiliation: Department of Anesthesiology and Perioperative Medicine, The University of Texas - MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
authors.forename: R
authors.initials: R
authors.lastname: Arunkumar
authors.affiliation: Department of Anesthesiology and Perioperative Medicine, The University of Texas - MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Potylchansky
authors.affiliation: Department of Anesthesiology and Perioperative Medicine, The University of Texas - MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
authors.forename: R
authors.initials: R
authors.lastname: Grasu
authors.affiliation: Department of Anesthesiology and Perioperative Medicine, The University of Texas - MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
authors.forename: A
authors.initials: A
authors.lastname: Dang
authors.affiliation: Department of Anesthesiology and Perioperative Medicine, The University of Texas - MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
authors.forename: R
authors.initials: R
authors.lastname: Carlson
authors.affiliation: Department of Anesthesiology and Perioperative Medicine, The University of Texas - MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
authors.forename: C
authors.initials: C
authors.lastname: Cowels
authors.affiliation: Department of Anesthesiology and Perioperative Medicine, The University of Texas - MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
authors.forename: B
authors.initials: B
authors.lastname: Arnold
authors.affiliation: Department of Anesthesiology and Perioperative Medicine, The University of Texas - MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
authors.forename: T F
authors.initials: TF
authors.lastname: Rahlfs
authors.affiliation: Department of Anesthesiology and Perioperative Medicine, The University of Texas - MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
authors.forename: I
authors.initials: I
authors.lastname: Lipski
authors.affiliation: Colgate University, Hamilton, NY 13346, USA.
authors.forename: C
authors.initials: C
authors.lastname: Walsh
authors.affiliation: Department of Anesthesiology and Perioperative Medicine, The University of Texas - MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
authors.forename: A T
authors.initials: AT
authors.lastname: Nguyen
authors.affiliation: Department of Biostatistics, The University of Texas - MD Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: L
authors.initials: L
authors.lastname: Feng
authors.affiliation: Department of Anesthesiology and Perioperative Medicine, The University of Texas - MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA; Anesthesiology and Surgical Oncology Research Group, Houston, TX 77401, USA. Electronic address: jcata@mdanderson.org.
authors.forename: J P
authors.initials: JP
authors.lastname: Cata
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000401:mortality / Q000601:surgery*; D005260:Female; D005909:Glioblastoma / Q000401:mortality / Q000601:surgery*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000009:adverse effects / Q000379:methods; D011183:Postoperative Complications / Q000517:prevention & control*; D057234:Preoperative Period; D016019:Survival Analysis
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
keywords: Glioblastoma; Statins; Surgery; Survival