title: Evaluation of the adjunctive effect of platelet-rich fibrin to enamel matrix derivative in the treatment of intrabony defects. Six-month results of a randomized, split-mouth, controlled clinical study.
abstract: This study aimed to compare the results obtained with enamel matrix derivative (EMD) and EMD + platelet-rich fibrin (PRF) in the treatment of intrabony defects (IBDs) in chronic periodontitis patients.
  
  
  
  Using a split-mouth design, 28 paired IBDs were randomly treated either with EMD or with EMD + PRF. Clinical and radiographic measurements including clinical attachment level (CAL), probing depth (PD), gingival recession (GR), defect depth (DD), defect width (DW) and defect angle (DA) were recorded at baseline (BL) and at six months following therapy.
  
  
  
  BL clinical and radiographic measurements were similar for EMD and EMD + PRF groups. Although postsurgical measurements revealed significant reduction for PD and CAL in both groups, no intergroup difference was detected. When EMD and EMD + PRF groups were compared, defect fill was not also statistically different.
  
  
  
  Both therapies resulted in significant clinical improvement in IBD treatment. Addition of PRF did not improve the clinical and radiographic outcomes.
authors.affiliation: Periodontology Department, Faculty of Dentistry, Gaziosmanpasa University, Tokat, Turkey.
authors.forename: Humerya
authors.initials: H
authors.lastname: Aydemir Turkal
authors.affiliation: Periodontology Department, Faculty of Dentistry, Kirikkale University, Kirikkale, Turkey.
authors.forename: Serhat
authors.initials: S
authors.lastname: Demirer
authors.affiliation: Biostatistics Department, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: Anil
authors.initials: A
authors.lastname: Dolgun
authors.affiliation: Periodontology Department, Faculty of Dentistry, Hacettepe University, Ankara, Turkey. monsieur_gencay@yahoo.com.
authors.forename: Huseyin Gencay
authors.initials: HG
authors.lastname: Keceli
mesh_terms: D016301:Alveolar Bone Loss; D003743:Dental Enamel; D003746:Dental Enamel Proteins; D005500:Follow-Up Studies; D006801:Humans; D017622:Periodontal Attachment Loss; D010514:Periodontal Pocket; D000073183:Platelet-Rich Fibrin
chemical_list: D003746:Dental Enamel Proteins
keywords: emdogain; intrabony defect; periodontal regeneration; platelet-rich fibrin; treatment