title: Cutting Edge: ACVRL1 Signaling Augments CD8α+ Dendritic Cell Development.
abstract: Dendritic cells (DCs) are a collection of different subtypes, each of which is characterized by specific surface markers, gene-expression patterns, and distinct functions. Members of the IFN regulatory factor family play critical roles in DC development and functions. Recently, Irf8 was shown to activate TGF-β signaling, which led to exacerbated neuroinflammation in the experimental autoimmune encephalomyelitis mouse model. We analyzed the effect of Irf8 on TGF-β/bone morphogenetic protein pathway-specific genes in DCs and identified Acvrl1, a type I TGF-β superfamily receptor, as a gene strongly induced by Irf8 expression. Among various DC subtypes, Acvrl1 is differentially expressed in CD8α(+) DCs. ACVRL1 signaling augmented Irf8-directed classical CD8α(+) DC development. Irf8 expression is essential for plasmacytoid DC and CD8α(+) DC development, and this study demonstrates that ACVRL1 signaling plays a pivotal role whereby it suppresses plasmacytoid DC development while enhancing that of CD8α(+) DCs, thus contributing to DC diversity development.
authors.affiliation: Laboratory of Innate Immunity, National Institute of Immunology, New Delhi, Delhi 110067, India.
authors.forename: Rohit
authors.initials: R
authors.lastname: Verma
authors.affiliation: Laboratory of Innate Immunity, National Institute of Immunology, New Delhi, Delhi 110067, India.
authors.forename: Hemant
authors.initials: H
authors.lastname: Jaiswal
authors.affiliation: Laboratory of Innate Immunity, National Institute of Immunology, New Delhi, Delhi 110067, India.
authors.forename: Kuldeep Singh
authors.initials: KS
authors.lastname: Chauhan
authors.affiliation: Laboratory of Innate Immunity, National Institute of Immunology, New Delhi, Delhi 110067, India.
authors.forename: Monika
authors.initials: M
authors.lastname: Kaushik
authors.affiliation: Laboratory of Innate Immunity, National Institute of Immunology, New Delhi, Delhi 110067, India tailorp@nii.ac.in.
authors.forename: Prafullakumar
authors.initials: P
authors.lastname: Tailor
mesh_terms: D030201:Activin Receptors, Type I / Q000276:immunology / Q000378:metabolism*; D030301:Activin Receptors, Type II; D000818:Animals; D016827:CD8 Antigens / Q000276:immunology; D002454:Cell Differentiation / Q000276:immunology*; D003713:Dendritic Cells / Q000166:cytology* / Q000276:immunology* / Q000378:metabolism; D050835:Interferon Regulatory Factors / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D015398:Signal Transduction / Q000276:immunology*; D000099185:Interferon Regulatory Factor-8
chemical_list: D030201:Activin Receptors, Type I; D030301:Activin Receptors, Type II; D016827:CD8 Antigens; D050835:Interferon Regulatory Factors; D000099185:Interferon Regulatory Factor-8; C409469:CD8 antigen, alpha chain; C498931:Acvrl1 protein, mouse