title: Innovations in deep brain stimulation methodology.
abstract: Deep brain stimulation is a powerful clinical method for movement disorders that no longer respond satisfactorily to pharmacological management, but its progress has been hampered by stagnation in technological procedure solutions and device development. Recently, the combined research efforts of bioengineers, neuroscientists, and clinicians have helped to better understand the mechanisms of deep brain stimulation, and solutions for the translational roadblock are emerging. Here, we define the needs for methodological advances in deep brain stimulation from a neurophysiological perspective and describe technological solutions that are currently evaluated for near-term clinical application. © 2016 International Parkinson and Movement Disorder Society.
authors.affiliation: Department of Neurology, Charité, Berlin, Germany.
authors.forename: Andrea A
authors.initials: AA
authors.lastname: Kühn
authors.affiliation: Department of Neurology, University Hospital of Würzburg, Würzburg, Germany.
authors.forename: Jens
authors.initials: J
authors.lastname: Volkmann
mesh_terms: D020811:Biomedical Technology / Q000379:methods* / Q000639:trends; D046690:Deep Brain Stimulation / Q000379:methods* / Q000639:trends; D006801:Humans; D009069:Movement Disorders / Q000628:therapy*
keywords: Parkinson's disease; basal ganglia; deep brain stimulation; dystonia; local field potentials; oscillations; tremor