title: Interaction of the pyridoindole stobadine with alkoxyl and stable free radicals.
abstract: Stobadine, a pyridoindole derivative which has been synthesized in search of new antiarrhytmic drugs, was able to interact with alpha-diphenyl-beta-picrylhydrazyl (DPPH(.)) a stable free radical. Its scavenging potential was in the same order of magnitude as that of well known strong antioxidants. The scavenging effect of antioxidants tested increased in the order: stobadine, ascorbic acid, trolox, cysteine. Stobadine exerted a scavenging effect also towards alkoxyl radicals in a nonpolar solvent in the canthaxantin bleaching test. In this test stobadine was more effective than trolox.
authors.affiliation: a Institute of Biochemistry, University of Graz , Graz , Austria.
authors.forename: L
authors.initials: L
authors.lastname: Horakova
authors.affiliation: b Institute of Experimental Pharmacology, Slovak Academy of Sciences , Bratislava , Slovak Republic.
authors.forename: R J
authors.initials: RJ
authors.lastname: Schaur
authors.affiliation: c Faculty of Pharmacy , Comenius University , Bratislava , Slovak Republic.
authors.forename: P
authors.initials: P
authors.lastname: Balgavy
authors.affiliation: d Institute of General and Experimental Pathology, University of Graz , Graz , Austria.
authors.forename: G
authors.initials: G
authors.lastname: Egger