title: Manifestations of systemic lupus erythematosus in female patients with polysomy X: Possible roles of chromosome X.
abstract: Clinical manifestations of systemic lupus erythematosus (SLE) in female patients with polysomy X have been less characterized as compared to those in male patients. Here, we describe a 28-year-old woman with trisomy X (47,XXX) who developed SLE. She had polyarthritis, hemolytic anemia, and was positive for anti-nuclear and anti-dsDNA antibodies. We discuss the common SLE manifestations with female polysomy X and the possible link between the development of SLE and the presence of extra X-chromosomes.
authors.affiliation: a Department of Allergy and Clinical Immunology , Chiba University Hospital , Chiba , Japan.|b Department of Immunology, Division of Rheumatology , Mayo Clinic , Rochester , MN , USA , and.
authors.forename: Taro
authors.initials: T
authors.lastname: Iwamoto
authors.affiliation: a Department of Allergy and Clinical Immunology , Chiba University Hospital , Chiba , Japan.|c Department of Diabetes, Metabolism and Endocrinology , Chiba University Hospital , Chiba , Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Fujimoto
authors.affiliation: a Department of Allergy and Clinical Immunology , Chiba University Hospital , Chiba , Japan.
authors.forename: Kei
authors.initials: K
authors.lastname: Ikeda
authors.affiliation: a Department of Allergy and Clinical Immunology , Chiba University Hospital , Chiba , Japan.
authors.forename: Aiko
authors.initials: A
authors.lastname: Saku
authors.affiliation: a Department of Allergy and Clinical Immunology , Chiba University Hospital , Chiba , Japan.
authors.forename: Sohei
authors.initials: S
authors.lastname: Makita
authors.affiliation: a Department of Allergy and Clinical Immunology , Chiba University Hospital , Chiba , Japan.
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Furuta
authors.affiliation: b Department of Immunology, Division of Rheumatology , Mayo Clinic , Rochester , MN , USA , and.
authors.forename: Timothy B
authors.initials: TB
authors.lastname: Niewold
authors.affiliation: a Department of Allergy and Clinical Immunology , Chiba University Hospital , Chiba , Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakajima
mesh_terms: D000328:Adult; D041321:Chromosomes, Human, X / Q000235:genetics; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D012729:Sex Chromosome Aberrations; D058533:Sex Chromosome Disorders of Sex Development / Q000150:complications*; D014314:Trisomy
keywords: Arthritis; Female; Hemolytic anemia; Systemic lupus erythematosus; Trisomy X