title: Insights on different analysis techniques in the monothermal and bithermal caloric test - which parameter should we use to quantify vestibular function?
abstract: To investigate the use of maximum slow component velocity (MSCV) and time-constant duration (TCd) of elicited nystagmus in quantifying the caloric response and to assess the efficacy of these parameters in the monothermal screening test.
  
  
  
  Retrospective analysis of caloric results obtained from 150 patients. Bithermal unilateral weakness (UW), directional preponderance (DP), monothermal caloric asymmetry (MCA) based on warm or cool irrigations only, were calculated using both MSCV and TCd.
  
  
  
  66 males and 84 females, aged 16-88 years (μ = 50, σ = 17), who underwent vestibular assessment.
  
  
  
  The correlation-coefficient between bithermal caloric unilateral weaknesses calculated using either MSCV or TCdis 0.155 (p < 0.01). Using MSCV and setting significant MCA at 10%, the sensitivity and specificity were respectively 100% and 34% for monothermal warm and 82% and 53% for monothermal cool tests. Using TCdand setting significant MCA at 5%, the sensitivity and specificity were respectively 90% and 77% for monothermal warm and 100% and 74% for monothermal cool tests.
  
  
  
  In the monothermal warm caloric test, MSCV can be used more reliably than monothermal cool to predict normal bithermal caloric response. The reverse is true if using TCd. Unilateral-weakness calculated using TCdand MSCV were poorly correlated and therefore likely to be demonstrating different aspects of vestibular function.
authors.affiliation: a St George's University Hospitals NHS Foundation Trust , London , UK and.|b Ear Institute, University College London , London , UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Radomskij
authors.affiliation: a St George's University Hospitals NHS Foundation Trust , London , UK and.
authors.forename: Samantha
authors.initials: S
authors.lastname: Smith
authors.affiliation: a St George's University Hospitals NHS Foundation Trust , London , UK and.
authors.forename: Sudhagar
authors.initials: S
authors.lastname: Kuttva
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002150:Caloric Tests / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009759:Nystagmus, Pathologic / Q000175:diagnosis; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013696:Temperature; D015837:Vestibular Diseases / Q000175:diagnosis*; D014722:Vestibule, Labyrinth / Q000503:physiopathology; D055815:Young Adult
keywords: Anatomy & physiology; instrumentation; medical audiology; vestibular