title: Triterpenoids from the stems of Tripterygium regelii.
abstract: Three new triterpenoids, triregelolides A, B (1, 2), and triregeloic acid (3), were isolated from the stems of Tripterygium regelii along with twenty known triterpene analogues (4-23). The structures of three new compounds were identified by analyzing their NMR spectroscopic and HRESIMS data. Compounds 4, 7, 8, 10, 13, 14, 17, 21-23 were isolated from T. regelii for the first time. Compounds 3, 5, 6, 8, 9, 10, 14 and 16 showed inhibitory effects on the proliferation of human breast cancer cells MCF-7 by 24.1%, 69.6%, 72.8%, 21.6%, 23.1%, 43.3%, 25.5% and 23.5% (p<0.05) at a concentration of 10μM, respectively.
authors.affiliation: State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, China.
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Fan
authors.affiliation: State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, China; Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Naresuan University, Muang, Phitsanulok, Thailand, 65000.
authors.forename: Supawadee
authors.initials: S
authors.lastname: Parhira
authors.affiliation: State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, China.
authors.forename: Guo-Yuan
authors.initials: GY
authors.lastname: Zhu
authors.affiliation: State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, China.
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Jiang
authors.affiliation: State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, China. Electronic address: lpbai@must.edu.mo.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Bai
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification; D045744:Cell Line, Tumor; D006801:Humans; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry*; D029757:Tripterygium / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D014315:Triterpenes
keywords: Celastrol (PubChem CID: 122,724); Tripterygium regelii Triterpenoids Cytotoxicity; demethylregelin (PubChem CID: 44,559,663); demethylzeylasteral (PubChem CID: 10,322,911); dulcioic acid (PubChem CID: 101,051,955); polpunonic acid (PubChem CID: 343,427); regelin (PubChem CID: 163,808); regelin D (PubChem CID: 129,520); regelinol (PubChem CID: 163,809); tripterygic acid A (PubChem CID: 21,672,627); triptocallic acid A (PubChem CID: 44,575,704); triptocalline A (PubChem CID: 44,559,634); triptotriterpenic acid B (PubChem CID: 195,563); wilforlide A (PubChem CID: 158,477); wilforlide B (PubChem CID: 174,362); wilforol A (PubChem CID: 10,096,097)