title: Altered Spontaneous Brain Activity in Cortical and Subcortical Regions in Parkinson's Disease.
abstract: Purpose. The present study aimed to explore the changes of amplitude of low-frequency fluctuations (ALFF) at rest in patients with Parkinson's disease (PD). Methods. Twenty-four PD patients and 22 healthy age-matched controls participated in the study. ALFF was measured on the whole brain of all participants. A two-sample t-test was then performed to detect the group differences with age, gender, education level, head motion, and gray matter volume as covariates. Results. It was showed that PD patients had significantly decreased ALFF in the left thalamus/caudate and right insula/inferior prefrontal gyrus, whereas they had increased ALFF in the right medial prefrontal cortex (BA 8/6) and dorsolateral prefrontal cortex (BA 9/10). Conclusions. Our results indicated that significant alterations of ALFF in the subcortical regions and prefrontal cortex have been detected in PD patients, independent of age, gender, education, head motion, and structural atrophy. The current findings further provide insights into the biological mechanism of the disease.
authors.affiliation: College of Computer Science and Technology, Taiyuan University of Technology, Taiyuan 030024, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Xiang
authors.affiliation: Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China; Beijing Key Lab of MRI and Brain Informatics, Beijing 100053, China.
authors.forename: Xiuqin
authors.initials: X
authors.lastname: Jia
authors.affiliation: College of Computer Science and Technology, Taiyuan University of Technology, Taiyuan 030024, China.
authors.forename: Huizhuo
authors.initials: H
authors.lastname: Li
authors.affiliation: College of Computer Science and Technology, Taiyuan University of Technology, Taiyuan 030024, China.
authors.forename: Jiawei
authors.initials: J
authors.lastname: Qin
authors.affiliation: Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China; Beijing Key Lab of MRI and Brain Informatics, Beijing 100053, China.
authors.forename: Peipeng
authors.identifier: 0000-0003-3795-4134
authors.initials: P
authors.lastname: Liang
authors.affiliation: Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China; Beijing Key Lab of MRI and Brain Informatics, Beijing 100053, China.
authors.forename: Kuncheng
authors.initials: K
authors.lastname: Li