title: Proteomics approaches in cervical cancer: focus on the discovery of biomarkers for diagnosis and drug treatment monitoring.
abstract: The HPV virus accounts for the majority of cervical cancer cases. Although a diagnostic tool (Pap Test) is widely available, cervical cancer incidence still remains high worldwide, and especially in developing countries, attributed to a large extent to suboptimal sensitivities of the Pap test and unavailability of the test in developing countries.
  
  
  
  Proteomics approaches have been used in order to understand the HPV virus correlation to cervical cancer pathology, as well as to discover putative biomarkers for early cervical cancer diagnosis and drug mode of action. Expert commentary: The present review summarizes the latest in vitro and in vivo proteomic studies for the discovery of putative cervical cancer biomarkers and the evaluation of available drugs and treatments.
authors.affiliation: a Biotechnology Division , Biomedical Research Foundation, Academy of Athens (BRFAA) , Athens , Greece.|b Laboratory of Biology , University of Athens School of Medicine , Athens , Greece.
authors.forename: Georgia
authors.initials: G
authors.lastname: Kontostathi
authors.affiliation: a Biotechnology Division , Biomedical Research Foundation, Academy of Athens (BRFAA) , Athens , Greece.
authors.forename: Jerome
authors.initials: J
authors.lastname: Zoidakis
authors.affiliation: b Laboratory of Biology , University of Athens School of Medicine , Athens , Greece.|c Cell and Gene Therapy Laboratory , Biomedical Research Foundation, Academy of Athens (BRFAA) , Athens , Greece.
authors.forename: Nicholas P
authors.initials: NP
authors.lastname: Anagnou
authors.affiliation: c Cell and Gene Therapy Laboratory , Biomedical Research Foundation, Academy of Athens (BRFAA) , Athens , Greece.|d First Department of Obstetrics and Gynecology , University of Athens School of Medicine , Athens , Greece.
authors.forename: Kalliopi I
authors.initials: KI
authors.lastname: Pappa
authors.affiliation: a Biotechnology Division , Biomedical Research Foundation, Academy of Athens (BRFAA) , Athens , Greece.
authors.forename: Antonia
authors.initials: A
authors.lastname: Vlahou
authors.affiliation: a Biotechnology Division , Biomedical Research Foundation, Academy of Athens (BRFAA) , Athens , Greece.
authors.forename: Manousos
authors.initials: M
authors.lastname: Makridakis
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000235:genetics* / Q000473:pathology / Q000821:virology; D040901:Proteomics; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor
keywords: Cervical cancer; biomarkers; drugs; proteomics; treatment