title: Metastatic pattern of invasive lobular carcinoma of the breast-Emphasis on gastric metastases.
abstract: OBJECTIVE
  Breast invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC) have different metastatic patterns, but the exact pattern of metastases from ILC is poorly known. This study aimed to determine the frequency of ILC metastases in atypical locations, with an emphasis on gastric metastases.
  
  
  METHODS
  Patients with ILC treated at the Saint-Sacrement Hospital (Quebec City, Canada) and the Maisonneuve-Rosemont Hospital (Montreal, Canada) between January 2003 and December 2009 were retrospectively reviewed. Demographic, clinical, and follow-up data were retrieved from the medical charts. Metastases that were diagnosed during follow-up were recorded.
  
  
  RESULTS
  Among the 481 patients with ILC, 74 (15.4%) were diagnosed with metastases after a median follow-up of 46 months. Among these 74 patients, 41.9% had metastases in atypical sites. Five patients were diagnosed with histologically confirmed gastric metastases of ILC.
  
  
  CONCLUSIONS
  Metastases of breast ILC to atypical sites might be more frequent than previously reported. Clinicians should keep a high level of suspicion when a patient with a history of ILC develops digestive symptoms. It is important to differentiate metastases from a primary GI tumor by using immunohistochemical markers. J. Surg. Oncol. 2016;114:543-547. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Faculté de Médecine, Département de Chirurgie, Université Laval, Cité Universitaire, Québec, Québec, Canada.
authors.forename: Ali
authors.initials: A
authors.lastname: El-Hage
authors.affiliation: Faculté de Médecine, Département de Chirurgie, Université Laval, Cité Universitaire, Québec, Québec, Canada.
authors.forename: Carolanne
authors.initials: C
authors.lastname: Ruel
authors.affiliation: Faculté de Médecine, Département de Chirurgie, Université de Montréal, Montréal, Québec, Canada.
authors.forename: Wahiba
authors.initials: W
authors.lastname: Afif
authors.affiliation: Faculté de Médecine, Département de Chirurgie, Université Laval, Cité Universitaire, Québec, Québec, Canada.
authors.forename: Hussein
authors.initials: H
authors.lastname: Wissanji
authors.affiliation: Faculté de Médecine, Département de Chirurgie, Université de Montréal, Montréal, Québec, Canada.|Centre des Maladies du Sein Deschênes-Fabia, CHU de Québec-Université Laval, Québec, Québec, Canada.|Axe Oncology, Centre de Recherche du CHU de Québec-Université Laval, Québec, Québec, Canada.
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Hogue
authors.affiliation: Faculté de Médecine, Département de Chirurgie, Université Laval, Cité Universitaire, Québec, Québec, Canada.|Faculté de Médecine, Département de Chirurgie, Université de Montréal, Montréal, Québec, Canada.|Centre des Maladies du Sein Deschênes-Fabia, CHU de Québec-Université Laval, Québec, Québec, Canada.|Axe Oncology, Centre de Recherche du CHU de Québec-Université Laval, Québec, Québec, Canada.
authors.forename: Christine
authors.initials: C
authors.lastname: Desbiens
authors.affiliation: Faculté de Médecine, Département de Chirurgie, Université de Montréal, Montréal, Québec, Canada.
authors.forename: Guy
authors.initials: G
authors.lastname: Leblanc
authors.affiliation: Faculté de Médecine, Département de Chirurgie, Université Laval, Cité Universitaire, Québec, Québec, Canada. ricpoirier@me.com.|Faculté de Médecine, Département de Chirurgie, Université de Montréal, Montréal, Québec, Canada. ricpoirier@me.com.|Centre des Maladies du Sein Deschênes-Fabia, CHU de Québec-Université Laval, Québec, Québec, Canada. ricpoirier@me.com.|Axe Oncology, Centre de Recherche du CHU de Québec-Université Laval, Québec, Québec, Canada. ricpoirier@me.com.
authors.forename: Éric
authors.initials: É
authors.lastname: Poirier
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology*; D002170:Canada; D018275:Carcinoma, Lobular / Q000453:epidemiology / Q000556:secondary*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000556:secondary*
keywords: breast cancer; gastric metastasis; invasive lobular carcinoma; metastasis