title: Evaluation of esophageal intramural pseudo-diverticulosis using high-resolution manometry.
abstract: Esophageal intramural pseudo-diverticulosis (EIPD) is a rare disease characterized by multiple small flask-shaped pouches in the esophageal wall, with the predominant symptom of chronic progressive or intermittent dysphagia. However, its etiology and pathogenesis remain unknown. We present a case of EIPD evaluated with high-resolution manometry in a 75-year-old man with food impaction after eating beef, who came to our emergency department. The patient experienced similar episodes three times previously, though the cause was unknown. Computed tomography (CT) findings revealed diffuse wall thickness in the upper intrathoracic esophagus, while esophagogastroduodenoscopy showed multiple small depressions and several white plaque patches, and a barium meal esophagogram showed characteristic multiple small outpouching areas. From these findings, we diagnosed the patient with EIPD. In addition, high-resolution manometry revealed strong contractions in the distal esophagus. We started an administration of isosorbide dinitrate, because abnormal esophageal motility may have been causative of the condition and development of pseudo-diverticulosis. Thereafter, the patient had a good clinical course without food impaction. Elevated intra-esophageal luminal pressure caused by abnormal esophageal motility seems to be an important factor in the pathogenesis of EIPD in some cases.
authors.affiliation: Second Department of Internal Medicine, Shimane University School of Medicine, 89-1 Enya-cho, Izumo-shi, Shimane, 693-8501, Japan. aimi@med.shimane-u.ac.jp.
authors.forename: Masahito
authors.initials: M
authors.lastname: Aimi
authors.affiliation: Second Department of Internal Medicine, Shimane University School of Medicine, 89-1 Enya-cho, Izumo-shi, Shimane, 693-8501, Japan.
authors.forename: Hironobu
authors.initials: H
authors.lastname: Mikami
authors.affiliation: Second Department of Internal Medicine, Shimane University School of Medicine, 89-1 Enya-cho, Izumo-shi, Shimane, 693-8501, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Izumi
authors.affiliation: Second Department of Internal Medicine, Shimane University School of Medicine, 89-1 Enya-cho, Izumo-shi, Shimane, 693-8501, Japan.
authors.forename: Eiko
authors.initials: E
authors.lastname: Okimoto
authors.affiliation: Department of Gastroenterology, Matsue Red Cross Hospital, 200 Horo-machi, Matsue-shi, Shimane, 690-8506, Japan.
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Tada
authors.affiliation: Second Department of Internal Medicine, Shimane University School of Medicine, 89-1 Enya-cho, Izumo-shi, Shimane, 693-8501, Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Mishiro
authors.affiliation: Second Department of Internal Medicine, Shimane University School of Medicine, 89-1 Enya-cho, Izumo-shi, Shimane, 693-8501, Japan.
authors.forename: Norihisa
authors.initials: N
authors.lastname: Ishimura
authors.affiliation: Second Department of Internal Medicine, Shimane University School of Medicine, 89-1 Enya-cho, Izumo-shi, Shimane, 693-8501, Japan.
authors.forename: Shunji
authors.initials: S
authors.lastname: Ishihara
authors.affiliation: Second Department of Internal Medicine, Shimane University School of Medicine, 89-1 Enya-cho, Izumo-shi, Shimane, 693-8501, Japan.
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Kinoshita
mesh_terms: D000368:Aged; D003680:Deglutition Disorders / Q000209:etiology; D004936:Diverticulum, Esophageal / Q000150:complications / Q000175:diagnosis*; D015154:Esophageal Motility Disorders / Q000150:complications / Q000175:diagnosis; D004940:Esophageal Stenosis / Q000150:complications / Q000175:diagnosis; D004945:Esophagoscopy; D006801:Humans; D008297:Male; D008365:Manometry / Q000379:methods; D014057:Tomography, X-Ray Computed
keywords: Abnormal esophageal motility; Dysphagia; Esophageal diverticulum; High-resolution manometry