title: Rab and Arf G proteins in endosomal trafficking and cell surface homeostasis.
abstract: The dynamics of membrane fusion, fission, cargo sorting and organelle maturation in endosomal membrane systems is regulated by Rab and Arf small G proteins. Defining the regulators, effectors and sites of action for each Rab and Arf will enhance our understanding of how endocytic membrane traffic is orchestrated and functions in differentiated cell types. Recent work has also shown how Rab35 and Arf6 might serve as input sensors for 2 forms of endocytosis to balance membrane trafficking to preserve cell surface homeostasis.
authors.affiliation: a Cell Biology and Physiology Center, NHLBI, NIH , Bethesda , MD , USA.
authors.forename: Julie G
authors.initials: JG
authors.lastname: Donaldson
authors.affiliation: a Cell Biology and Physiology Center, NHLBI, NIH , Bethesda , MD , USA.
authors.forename: Debra L
authors.initials: DL
authors.lastname: Johnson
authors.affiliation: a Cell Biology and Physiology Center, NHLBI, NIH , Bethesda , MD , USA.
authors.forename: Dipannita
authors.initials: D
authors.lastname: Dutta
mesh_terms: D000818:Animals; D011992:Endosomes / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D020559:Monomeric GTP-Binding Proteins / Q000378:metabolism*; D011485:Protein Binding; D021381:Protein Transport; D020691:rab GTP-Binding Proteins / Q000378:metabolism
chemical_list: D020559:Monomeric GTP-Binding Proteins; D020691:rab GTP-Binding Proteins
keywords: Arf6; GTPase; Rab35; T cell; cargo sorting; cell polarity; clathrin-independent endocytosis; clathrin-mediated endocytosis