title: Comparative risk of hip fractures in elderly nursing home patients with depression using paroxetine and other selective serotonin reuptake inhibitors.
abstract: To evaluate comparative safety of paroxetine and other selective serotonin reuptake inhibitors (SSRIs) for the risk of hip fractures.
  
  
  
  A propensity score-matched retrospective cohort study was conducted using 2007-2010 Minimum Data Set linked Medicare data. Robust Cox proportional hazards model was used to evaluate the risk of hip fractures in depressed elderly nursing home residents.
  
  
  
  Cox analysis did not find any significant difference in the risk of hip fractures for the paroxetine users (hazard ratio: 1.09; 95% CI: 0.91-1.32) when compared with other SSRIs. Results from the sensitivity analysis supported the main findings.
  
  
  
  There was no differential risk of hip fractures between paroxetine and other SSRIs. Future studies are needed to evaluate other anticholinergic effects of paroxetine.
authors.affiliation: Senior Health Outcomes Researcher, Health Advocate, Westlake Village, CA, USA.
authors.forename: Vishal
authors.initials: V
authors.lastname: Bali
authors.affiliation: Department of Pharmaceutical Health Outcomes & Policy, College of Pharmacy, University of Houston, Texas Medical Center, 1441 Moursund Street, Houston, TX 77030-3407, USA.
authors.forename: Satabdi
authors.initials: S
authors.lastname: Chatterjee
authors.affiliation: Department of Pharmaceutical Health Outcomes & Policy, College of Pharmacy, University of Houston, Texas Medical Center, 1441 Moursund Street, Houston, TX 77030-3407, USA.
authors.forename: Michael L
authors.initials: ML
authors.lastname: Johnson
authors.affiliation: Department of Pharmaceutical Health Outcomes & Policy, College of Pharmacy, University of Houston, Texas Medical Center, 1441 Moursund Street, Houston, TX 77030-3407, USA.
authors.forename: Hua
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USA.
authors.forename: Ryan M
authors.initials: RM
authors.lastname: Carnahan
authors.affiliation: Department of Pharmaceutical Health Outcomes & Policy, College of Pharmacy, University of Houston, Texas Medical Center, 1441 Moursund Street, Houston, TX 77030-3407, USA.
authors.forename: Rajender R
authors.initials: RR
authors.lastname: Aparasu
mesh_terms: D000368:Aged; D003863:Depression / Q000188:drug therapy*; D005260:Female; D006620:Hip Fractures; D006801:Humans; D008297:Male; D009735:Nursing Homes / Q000706:statistics & numerical data; D017374:Paroxetine / Q000627:therapeutic use*; D012189:Retrospective Studies; D012306:Risk; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*
chemical_list: D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors
keywords: Medicare; SSRIs; comparative effectiveness; comparative risk; depression; elderly; hip fracture; nursing home residents; paroxetine; selective serotonin reuptake inhibitors