title: Expression of human selenoprotein genes selh, selk, selm, sels, selv, and gpx-6 in various tumor cell lines.
abstract: The expression level of the genes encoding six selenocysteine-containing human proteins was determined in the brain, cervical, liver, breast, prostate, and human fibrosarcoma cancer cells. It was found that a high level of expression in all studied types genes of tumor cells is characteristic for selh, selk, and selm genes, encoding SelH, SelK, and SelM proteins, respectively, whereas a complete lack of such expression was shown for gpx-6, selv, and sels genes. The results of this work can be regarded as a major prerequisite for further studies on the role of the three selenoproteins SelH, SelK, and SelM in the regulation of carcinogenesis processes associated with these types of cancer.
authors.affiliation: Institute of Cell Biophysics, Russian Academy of Sciences, ul. Institutskaya 2, Pushchino, Moscow oblast, 142290, Russia. 1928lv@mail.ru.
authors.forename: E G
authors.initials: EG
authors.lastname: Varlamova
authors.affiliation: Institute of Cell Biophysics, Russian Academy of Sciences, ul. Institutskaya 2, Pushchino, Moscow oblast, 142290, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Goltyaev
authors.affiliation: Institute of Cell Biophysics, Russian Academy of Sciences, ul. Institutskaya 2, Pushchino, Moscow oblast, 142290, Russia.
authors.forename: E E
authors.initials: EE
authors.lastname: Fesenko
mesh_terms: D045744:Cell Line, Tumor; D015870:Gene Expression; D006801:Humans; D009369:Neoplasms / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D051140:Selenoproteins / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger; D051140:Selenoproteins