title: Spatial resolution of cAMP signaling by soluble adenylyl cyclase.
abstract: G protein-coupled receptor signaling starts at the plasma membrane and continues at endosomal stations. In this issue, Inda et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201512075) show that different forms of adenylyl cyclase are activated at the plasma membrane versus endosomes, providing a rationale for the spatial encoding of cAMP signaling.
authors.affiliation: Fondazione Istituto FIRC di Oncologia Molecolare, 20139 Milan, Italy.
authors.forename: Giusi
authors.initials: G
authors.lastname: Caldieri
authors.affiliation: Fondazione Istituto FIRC di Oncologia Molecolare, 20139 Milan, Italy sara.sigismund@ifom.eu.
authors.forename: Sara
authors.initials: S
authors.lastname: Sigismund
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D011992:Endosomes / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism; D015398:Signal Transduction; D012995:Solubility
chemical_list: D043562:Receptors, G-Protein-Coupled; D000242:Cyclic AMP; D000262:Adenylyl Cyclases