title: The Successful Complete Remission Induction by Sorafenib Monotherapy in a FLT3-D835Y-Positive Patient with Refractory Acute Monocytic Leukemia.
abstract: Sorafenib has been shown to be active in AML patients with FLT3-ITD. However, the effect of sorafenib in AML patients with FLT-TKD has never been well determined. Moreover, acquisition of secondary FLT3 TKD mutations, mainly at D835 (D835F/H/V/Y), are recognized as the major mechanisms of resistance of AML patients with FLT3-ITD to sorafenib. It has been reported that sorafenib induced death of cells that expressed the FLT3-ITD or FLT3-D835G but not cells that expressed the FLT3-D835Y point mutant or wild-type FLT3 in vitro. Here, we report the successful complete remission induction by sorafenib monotherapy in a FLT3-D835Y-positive patient with refractory AML-M5 followed by allogeneic stem cell transplantation.
authors.affiliation: Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006 Jiangsu province People's Republic of China.|Collaborative Innovation Center of Hematology, Soochow University, Suzhou, People's Republic of China.
authors.forename: Yanhua
authors.identifier: 0000-0001-9099-0463
authors.initials: Y
authors.lastname: Yue
authors.affiliation: Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006 Jiangsu province People's Republic of China.|Collaborative Innovation Center of Hematology, Soochow University, Suzhou, People's Republic of China.
authors.forename: Song
authors.initials: S
authors.lastname: Jin
authors.affiliation: Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006 Jiangsu province People's Republic of China.|Collaborative Innovation Center of Hematology, Soochow University, Suzhou, People's Republic of China.
authors.forename: Ting
authors.initials: T
authors.lastname: Xu
authors.affiliation: Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006 Jiangsu province People's Republic of China.|Collaborative Innovation Center of Hematology, Soochow University, Suzhou, People's Republic of China.
authors.forename: Jin
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006 Jiangsu province People's Republic of China.|Collaborative Innovation Center of Hematology, Soochow University, Suzhou, People's Republic of China.
authors.forename: Liang
authors.initials: L
authors.lastname: Ma
authors.affiliation: Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006 Jiangsu province People's Republic of China.|Collaborative Innovation Center of Hematology, Soochow University, Suzhou, People's Republic of China.
authors.forename: Hongjie
authors.initials: H
authors.lastname: Shen
authors.affiliation: Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006 Jiangsu province People's Republic of China.|Collaborative Innovation Center of Hematology, Soochow University, Suzhou, People's Republic of China.
authors.forename: Depei
authors.initials: D
authors.lastname: Wu
authors.affiliation: Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006 Jiangsu province People's Republic of China.|Collaborative Innovation Center of Hematology, Soochow University, Suzhou, People's Republic of China.
authors.forename: Suning
authors.initials: S
authors.lastname: Chen
authors.affiliation: Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006 Jiangsu province People's Republic of China.|Collaborative Innovation Center of Hematology, Soochow University, Suzhou, People's Republic of China.
authors.forename: Miao
authors.initials: M
authors.lastname: Miao
keywords: Acute monocytic leukemia; Complete remission; FLT3-D835Y mutation; Sorafenib