title: Palladium(II)-Catalyzed ortho-Arylation of Aromatic Alcohols with a Readily Attachable and Cleavable Molecular Scaffold.
abstract: A palladium(II)-catalyzed C-H arylation process of alcohols has been developed. The strategy utilizes a novel quinoline-based hemiacetal scaffold that can direct the selective C-H bond functionalization. This reaction provides a useful method to construct biaryl compounds of benzyl alcohols in good to excellent yields. The new molecular scaffold can be readily attached, removed, and recovered.
authors.affiliation: Department of Chemistry, University of Georgia, Athens, GA, 30602, USA.
authors.forename: Qiankun
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Chemistry, University of Georgia, Athens, GA, 30602, USA.
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Knight
authors.affiliation: Department of Chemistry, University of Georgia, Athens, GA, 30602, USA. emferr@uga.edu.
authors.forename: Eric M
authors.initials: EM
authors.lastname: Ferreira
keywords: C−C coupling; C−H functionalization; arylation; palladium; quinoline acetal