title: "Pro-youthful" factors in the "labyrinth" of cardiac rejuvenation.
abstract: The mechanisms of aging and senescence include various endogenous and exogenous factors. Among cardiovascular diseases, heart failure is a typical age-related disease. New strategies to restore cardiomyocyte cells have been reported: endogenous substances that can regenerate the heart's cardiomyocytes have been described: follistatin like 1 (FSTL1), growth-differentiation factor 11 (GDF11) and insulin-like growth factor 1 (IGF-I). Manipulation of the different anti and pro- pathways is essential to discover new approaches to regenerative therapies.
authors.affiliation: Laboratoire de Physiopathologie et Pharmacologies Cardio-Métaboliques (LPPCM), INSERM UMR866, Université de Bourgogne Franche-Comté, Facultés des Sciences de Santé, 7 Boulevard Jeanne d'Arc, 21033 Dijon Cedex, France. Electronic address: luc.rochette@u-bourgogne.fr.
authors.forename: Luc
authors.initials: L
authors.lastname: Rochette
authors.affiliation: Laboratoire de Physiopathologie et Pharmacologies Cardio-Métaboliques (LPPCM), INSERM UMR866, Université de Bourgogne Franche-Comté, Facultés des Sciences de Santé, 7 Boulevard Jeanne d'Arc, 21033 Dijon Cedex, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Vergely
mesh_terms: D000375:Aging; D019485:Bone Morphogenetic Proteins / Q000502:physiology*; D038702:Follistatin-Related Proteins / Q000502:physiology*; D055412:Growth Differentiation Factors / Q000502:physiology*; D006333:Heart Failure / Q000378:metabolism; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D032383:Myocytes, Cardiac / Q000378:metabolism*; D012038:Regeneration; D012060:Rejuvenation
chemical_list: D019485:Bone Morphogenetic Proteins; D038702:Follistatin-Related Proteins; C492266:GDF11 protein, human; D055412:Growth Differentiation Factors; C583557:IGF1 protein, human; C448799:FSTL1 protein, human; D007334:Insulin-Like Growth Factor I
keywords: Cardiac; FSTL1; GDF11; IGF-I; Rejuvenation