title: Epidemiology and Pulmonary Physiology of Severe Asthma.
abstract: The epidemiology and physiology of severe asthma are inherently linked because of varying phenotypes and expressions of asthma throughout the population. To understand how to better treat severe asthma, we must use both population data and physiologic principles to individualize therapies among groups with similar expressions of this disease.
authors.affiliation: Department of Medicine, University of Vermont Medical Center, 111 Colchester Avenue, Burlington, VT 05401, USA.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: O'Toole
authors.affiliation: Division of Pulmonary and Critical Care Medicine, University of Vermont Medical Center, Given D208, 89 Beaumont Avenue, Burlington, VT 05405, USA.
authors.forename: Lucas
authors.initials: L
authors.lastname: Mikulic
authors.affiliation: Division of Pulmonary and Critical Care Medicine, University of Vermont College of Medicine, Given D213, 89 Beaumont Avenue, Burlington, VT 05405, USA. Electronic address: David.kaminsky@uvm.edu.
authors.forename: David A
authors.initials: DA
authors.lastname: Kaminsky
mesh_terms: D001249:Asthma / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology* / Q000628:therapy; D017048:Health Care Costs; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D017063:Outcome Assessment, Health Care; D010342:Patient Acceptance of Health Care / Q000706:statistics & numerical data; D010641:Phenotype; D011379:Prognosis; D012720:Severity of Illness Index
keywords: Airway hyperresponsiveness; Demographics; Gas trapping; Health care utilization; Lung elastic recoil; Phenotype; Pulmonary function; Ventilation heterogeneity