title: Increased risk of ischemic heart disease among subjects with cataracts: A population-based cohort study.
abstract: BACKGROUND
  Association between cataract and the risk of ischemic heart disease (IHD) development is not completely clear.
  
  
  OBJECTIVE
  The primary aim of the study was to evaluate the association between cataract and the risk of incident IHD. The secondary aim was to investigate the subsequent IHD risk of patients with cataracts undergoing cataract surgery.
  
  
  METHODS
  Retrospective data from the Longitudinal Health Insurance Database 2000 (LHID2000) was analyzed. Study participants were composed of patients with cataracts (International Classification of Diseases, 9th Revision, Clinical Modification [ICD-9-CM] code 366) (n = 32,456), and a comparison cohort without the cataracts (n = 32,456) from 2000 to 2010. Cox proportional hazards regression was used to address the hazard ratio (HR) of IHD associated with cataract.
  
  
  RESULTS
  Within 12 years of follow up, the overall incidence rates of IHD were 24.2 per 1000 person-years in the cataract cohort and 18.2 per 1000 person-years in the noncataract cohort with an adjusted hazard ratio (aHR) of 1.35 (95% CI = 1.29-1.41; P < 0.001). Furthermore, the cataract patients undergoing cataract surgery were associated with a higher risk of IHD compared with those cataract patients without surgery (aHR = 1.07, 95% CI: 1.01-1.14; P < 0.05).
  
  
  CONCLUSIONS
  Our finding suggested that patients with cataracts are at an increased risk of subsequent IHD development.
authors.affiliation: School of Medicine, College of Medicine, China Medical University Division of Cardiovascular Medicine, Department of Medicine Management Office for Health Data, China Medical University Hospital Graduate Institute of Clinical Medical Science, China Medical University Cardiovascular Research Laboratory, China Medical University Hospital, Taichung, Taiwan.
authors.forename: Wei-Syun
authors.initials: WS
authors.lastname: Hu
authors.forename: Cheng-Li
authors.initials: CL
authors.lastname: Lin
authors.forename: Shih-Sheng
authors.initials: SS
authors.lastname: Chang
authors.forename: Ming-Fong
authors.initials: MF
authors.lastname: Chen
authors.forename: Kuan-Cheng
authors.initials: KC
authors.lastname: Chang
mesh_terms: D002386:Cataract / Q000150:complications* / Q000453:epidemiology / Q000473:pathology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D012189:Retrospective Studies; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology