title: CD56 Negative Aggressive T Cell Large Granular Lymphocytic Leukemia.
abstract: T cell large granular lymphocytic leukemia is a clonal proliferation of cytotoxic large granular T cells positive for CD3 and CD8. It is a chronic lymphoproliferative disorder with an indolent course. Therapeutic options include observation and low dose chemotherapy. Rarely, they have an aggressive course. Such cases have expression of NK cell associated antigens like CD56 in the T cells. These cases require more aggressive therapy with acute lymphoblastic leukemia regimens. We report a case of fatal CD56 negative T cell large granular lymphocytic leukemia in a 38 year old lady.
authors.affiliation: Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Gorimedu, Puducherry, 605011 Puducherry India.
authors.forename: Mary Theresa
authors.initials: MT
authors.lastname: Sylvia
authors.affiliation: Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Gorimedu, Puducherry, 605011 Puducherry India.
authors.forename: Sajini Elizabeth
authors.initials: SE
authors.lastname: Jacob
authors.affiliation: Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Gorimedu, Puducherry, 605011 Puducherry India.
authors.forename: Debdatta
authors.initials: D
authors.lastname: Basu
authors.affiliation: Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Gorimedu, Puducherry, 605011 Puducherry India.
authors.forename: Deepak
authors.initials: D
authors.lastname: Amalnath
authors.affiliation: Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Gorimedu, Puducherry, 605011 Puducherry India.
authors.forename: Tarun Kumar
authors.initials: TK
authors.lastname: Dutta
keywords: Aggressive variant; CD56 negative; Large granular lymphocytes