title: [The relation between the low T3 syndrome in the clinical course of myocardial infarction and heart failure].
abstract: It has been proven that either excess or deficiency of thyroid hormones has harmful influence on the cardiovascular system function. On the other hand, severe systemic conditions like myocardial infarction or severe heart failure may affect thyroid hormones secretion and their peripheral conversion, leading to low T3 syndrome. Amongst many mechanisms causing T4 to T3 conversion disturbances, important role plays decreased activity of D1 deiodinase and increased activity of D3 deiodinase. The animal research confirmed that thyroid hormones influence cardiomiocytes phenotype and morphology. They inhibit inflammation, apoptosis and cardiac remodelling after myocardial infarction. It was also proven that free triiodothyronine similarly to brain natriuretic peptide predict long-term prognosis in chronic and acute heart failure patients. Potential influence of low T3 syndrome on the course of myocardial infarction and heart failure may have significant impact on the future research on individualization of myocardial infarction and heart failure treatment depending on patient's thyroid status.
authors.affiliation: Jagiellonian University Medical College, Krakow, Poland, John Paul II Hospital: Department of Coronary Disease and Heart Failure.
authors.forename: Magdalena Maria
authors.initials: MM
authors.lastname: Frączek
authors.affiliation: Jagiellonian University Medical College, Krakow, Poland, John Paul II Hospital: Department of Coronary Disease and Heart Failure; Noninvasive Cardiovascular Laboratory.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Gackowski
authors.affiliation: Jagiellonian University Medical College, Krakow, Poland, John Paul II Hospital: Department of Endocrinology.
authors.forename: Elwira
authors.initials: E
authors.lastname: Przybylik-Mazurek
authors.affiliation: Jagiellonian University Medical College, Krakow, Poland, John Paul II Hospital: Department of Coronary Disease and Heart Failure.
authors.forename: Jadwiga
authors.initials: J
authors.lastname: Nessler
mesh_terms: D000818:Animals; D005067:Euthyroid Sick Syndromes / Q000150:complications*; D006333:Heart Failure / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D006801:Humans; D009203:Myocardial Infarction / Q000209:etiology* / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D011379:Prognosis; D013963:Thyroid Hormones / Q000378:metabolism
chemical_list: D013963:Thyroid Hormones
keywords: heart failure; low T3 syndrome; myocardial infarction