title: Test of the recommended dialysis dose on one-year mortality of nondiabetic maintenance hemodialysis patients; observations from a single dialysis unit.
abstract: BACKGROUND
  The optimal delivered dialysis dose has been of a great interest for the last three decades, though a clear cut point has not been reached yet. We aimed to evaluate the relationship between one-year mortality and the delivered dialysis dose, which was recommended by Kidney Disease Outcomes Quality Initiative (KDOQI), in our maintenance hemodialysis (MHD) patients.
  
  
  METHODS
  This was a single center, prospective observational study with one year of follow-up. Patients with extremes of age, BMI, residual renal function, diabetes mellitus, severe infection malignancy, and recent hospitalization within the last three months were excluded. Demographic, anthropometric, laboratory, and outcome data (mortality as the primary) were prospectively collected. Patients were classified into two groups according to baseline spKt/V levels; group 1 (n = 20): spKt/V ≤ 1.4, group 2 (n = 60): spKt/V > 1.4.
  
  
  RESULTS
  Median (IQR) age and hemodialysis vintage of all patients (M/F: 41/39) were 49.5 (29) years and 60 (94) months, respectively. Both groups had similar characteristics, with the exception of significantly higher BMI (24 vs. 21.7, p = 0.012), serum creatinine and uric acids, and lower spKt/V (1.30 vs. 1.71, p < 0.001) in group 1. Overall death occurred in seven (8.75%) patients (5 from group 1 and 2 from group 2). Patients in group 1 had significantly higher one-year mortality rate and shorter survival time (25% vs. 3.3%, p = 0.003 and 43.9 vs. 47.3 weeks, p = 0.003, respectively).
  
  
  CONCLUSIONS
  Higher spKt/V (>1.4) was associated with a lower one-year mortality in this small cohort of patients.
authors.affiliation: a Department of Nephrology , Sisli Hamidiye Etfal Educational and Research Hospital , Istanbul , Turkey ;
authors.forename: Tuncay
authors.initials: T
authors.lastname: Sahutoglu
authors.affiliation: b Department of Internal Medicine, Faculty of Medicine , Recep Tayyip Erdogan University , Rize , Turkey.
authors.forename: Ekrem
authors.initials: E
authors.lastname: Kara
authors.affiliation: a Department of Nephrology , Sisli Hamidiye Etfal Educational and Research Hospital , Istanbul , Turkey ;
authors.forename: Elbis
authors.initials: E
authors.lastname: Ahbap
authors.affiliation: a Department of Nephrology , Sisli Hamidiye Etfal Educational and Research Hospital , Istanbul , Turkey ;
authors.forename: Tamer
authors.initials: T
authors.lastname: Sakaci
authors.affiliation: a Department of Nephrology , Sisli Hamidiye Etfal Educational and Research Hospital , Istanbul , Turkey ;
authors.forename: Yener
authors.initials: Y
authors.lastname: Koc
authors.affiliation: a Department of Nephrology , Sisli Hamidiye Etfal Educational and Research Hospital , Istanbul , Turkey ;
authors.forename: Taner
authors.initials: T
authors.lastname: Basturk
authors.affiliation: a Department of Nephrology , Sisli Hamidiye Etfal Educational and Research Hospital , Istanbul , Turkey ;
authors.forename: Mustafa
authors.initials: M
authors.lastname: Sevinc
authors.affiliation: a Department of Nephrology , Sisli Hamidiye Etfal Educational and Research Hospital , Istanbul , Turkey ;
authors.forename: Cuneyt
authors.initials: C
authors.lastname: Akgol
authors.affiliation: a Department of Nephrology , Sisli Hamidiye Etfal Educational and Research Hospital , Istanbul , Turkey ;
authors.forename: Zuhal Atan
authors.initials: ZA
authors.lastname: Ucar
authors.affiliation: a Department of Nephrology , Sisli Hamidiye Etfal Educational and Research Hospital , Istanbul , Turkey ;
authors.forename: Arzu
authors.initials: A
authors.lastname: Ozdemir Kayalar
authors.affiliation: a Department of Nephrology , Sisli Hamidiye Etfal Educational and Research Hospital , Istanbul , Turkey ;
authors.forename: Feyza Bayraktar
authors.initials: FB
authors.lastname: Caglayan
authors.affiliation: a Department of Nephrology , Sisli Hamidiye Etfal Educational and Research Hospital , Istanbul , Turkey ;
authors.forename: Abdulkadir
authors.initials: A
authors.lastname: Unsal
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006760:Hospitalization; D006801:Humans; D053208:Kaplan-Meier Estimate; D007676:Kidney Failure, Chronic / Q000401:mortality* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012372:ROC Curve; D006435:Renal Dialysis / Q000379:methods*; D012307:Risk Factors; D014421:Turkey; D055815:Young Adult
keywords: Hemodialysis; spKt/V; survival