title: Isolated Breast Relapse of Acute Lymphoblastic Leukemia After Allogeneic Hematopoietic Stem Cell Transplantation.
abstract: Isolated breast relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is less often seen. Chronic graft-versus-host disease (cGVHD) is effective in preventing marrow relapse, but cGVHD seems not to be effective extramedullary relapse (EMR). We report the case of isolated breast relapse after first allo-HSCT for acute lymphoblastic leukemia (ALL). A 47-year-old female was diagnosed with ALL achieved complete remission with salvage chemotherapy and underwent allo-HSCT from an HLA-matched sibling male donor. At 17 months post-transplant, she presented with a bilateral breast masses that confirmed the diagnosis lymphoblast involvement. She had no evidence of leukemia in her marrow that determined 100 % full-donor chimerism when she was relapsed in her both breasts.
authors.affiliation: Department of Hematology, Kocaeli University School of Medicine, Umuttepe, Kocaeli 41380 Turkey.
authors.forename: Esra Terzi
authors.initials: ET
authors.lastname: Demirsoy
authors.affiliation: Department of Hematology, Kocaeli University School of Medicine, Umuttepe, Kocaeli 41380 Turkey.
authors.forename: Elif Birtas
authors.initials: EB
authors.lastname: Atesoglu
authors.affiliation: Department of Hematology, Kocaeli University School of Medicine, Umuttepe, Kocaeli 41380 Turkey.
authors.forename: Pinar
authors.initials: P
authors.lastname: Tarkun
authors.affiliation: Department of Hematology, Kocaeli University School of Medicine, Umuttepe, Kocaeli 41380 Turkey.
authors.forename: Ayfer
authors.initials: A
authors.lastname: Gedük
authors.affiliation: Department of Patology, Kocaeli University School of Medicine, Umuttepe, Kocaeli 41380 Turkey.
authors.forename: Büşra Erşan
authors.initials: BE
authors.lastname: Erdem
authors.affiliation: Department of Hematology, Kocaeli University School of Medicine, Umuttepe, Kocaeli 41380 Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Hacihanefioglu
authors.affiliation: Department of Patology, Kocaeli University School of Medicine, Umuttepe, Kocaeli 41380 Turkey.
authors.forename: Mehmet Cengiz
authors.initials: MC
authors.lastname: Erçin
keywords: Acute lymphoblastic leukemia; Breast relapse; Stem cell transplantation