title: Angiotensin II acting on PVN induces sympathoexcitation and pressor responses via the PI3K-dependent pathway.
abstract: In vitro studies have shown that angiotensin II (ANG II), via activation of ANG II type 1 (AT1) receptor plays an important role on the neural control of the blood pressure (BP), through an intracellular signalling pathway involving PI3K in the paraventricular nucleus of the hypothalamus (PVN). However, to the best of our knowledge, no in vivo study has been performed yet to unravel the functional role of ANG II and its interaction with PI3K pathways in the neural control of circulation of non-anesthetized animals. Here, we demonstrate that exogenous ANG II microinjected into the PVN in anaesthetic-free animals evokes an increase in sympathetic nerve activity and BP in a PI3K-dependent manner.
authors.affiliation: Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, 05508-000 Sao Paulo, SP, Brazil.
authors.forename: L
authors.initials: L
authors.lastname: Buttler
authors.affiliation: Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, 05508-000 Sao Paulo, SP, Brazil.
authors.forename: I M
authors.initials: IM
authors.lastname: Ribeiro
authors.affiliation: Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, 05508-000 Sao Paulo, SP, Brazil.
authors.forename: H C
authors.initials: HC
authors.lastname: Ferreira-Neto
authors.affiliation: Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, 05508-000 Sao Paulo, SP, Brazil. Electronic address: antunes@icb.usp.br.
authors.forename: V R
authors.initials: VR
authors.lastname: Antunes
mesh_terms: D000804:Angiotensin II / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects* / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D017208:Rats, Wistar; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000503:physiopathology; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
chemical_list: D014662:Vasoconstrictor Agents; D000804:Angiotensin II; D019869:Phosphatidylinositol 3-Kinases
keywords: Hypertension angiotensin II; PI3K; Paraventricular nucleus of hypothalamus; Sympathoexcitation