title: Relationship between post-extraction pain and acute pulpitis: a randomised trial using third molars.
abstract: BACKGROUND
  The aim of the present study was to examine the relationship between post-extraction pain and acute pulpitis in third molars.
  
  
  METHODS
  This study was a randomised controlled trial. Sixty patients requiring removal of a single maxillary third molar with acute pulpitis were included and randomly divided into two groups: group A (n = 30); and group B (n = 30). In group A, third molars were directly extracted, and group B received endodontic therapy (pulp chamber opening and drainage) and underwent extraction 24 hours later, aiming to eliminate the acute inflammation. Another 30 patients requiring removal of a single maxillary third molar and with the same inclusion criteria but without caries or acute pulpitis were recruited into group C, in which the maxillary third molars were also directly extracted. The level of postoperative pain reported each day among the three groups was statistically evaluated.
  
  
  RESULTS
  On the first, second and third days after surgery, there was a statistically significant difference between group A and group B and between group A and group C, but there was no statistically significant difference between group B and group C.
  
  
  CONCLUSIONS
  The results of the present study indicate that there is more pain when third molars with acute pulpitis are directly removed compared with the pain level of the removal of third molars without acute pulpitis.
authors.affiliation: Department of Endodontics, School and Hospital of Stomatology, Wuhan University, Wuhan, China.|The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory for Oral Biomedical Engineering of the Ministry of Education, Wuhan University, Wuhan, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Stomatology, Huangmei People's Hospital, Huangmei, China.
authors.forename: Yong-Bo
authors.initials: YB
authors.lastname: Dai
authors.affiliation: Department of Stomatology, Huangmei People's Hospital, Huangmei, China.
authors.forename: Peng-Cheng
authors.initials: PC
authors.lastname: Wan
authors.affiliation: The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory for Oral Biomedical Engineering of the Ministry of Education, Wuhan University, Wuhan, China.|Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
authors.forename: Dong-Dong
authors.initials: DD
authors.lastname: Xu
authors.affiliation: The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory for Oral Biomedical Engineering of the Ministry of Education, Wuhan University, Wuhan, China.|Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Guo
authors.affiliation: The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory for Oral Biomedical Engineering of the Ministry of Education, Wuhan University, Wuhan, China.|Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Li
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008964:Molar, Third / Q000601:surgery*; D010149:Postoperative Pain / Q000209:etiology*; D011671:Pulpitis / Q000150:complications / Q000601:surgery*; D014081:Tooth Extraction / Q000009:adverse effects* / Q000379:methods; D055815:Young Adult
keywords: Third molars; acute pulpitis; extraction; nerve; pain