title: Effect of Shin'iseihaito on murine allergic reaction induced by nasal sensitization.
abstract: Shin'iseihaito (Magnolia Flower Lung-Clearing Decoction; xīn yí qīng fèi tāng), a formula of traditional Japanese kampo medicine ( rì běn hàn yī) and traditional Chinese medicine (TCM; zhōng yī), has been used for the treatment of chronic sinusitis. The objective of this study was to evaluate the anti-allergic effect of shin'iseihaito on murine allergic reaction induced by nasal sensitization using ovalbumin (OVA) as an antigen. Extract of shin'iseihaito (SSHT) could reduce the eosinophil, serum IgE and interleukin (IL)-4 levels, while increased the interferon (IFN)-γ levels in allergic mouse. Furthermore, allergic-murine serum treated with SSHT could not activate passive cutaneous anaphylaxis (PCA) reaction in murine model. Thus, our study showed that SSHT may possess anti-allergic activity. We suggested that SSHT may contribute to inhibit the exacerbation of allergic reaction induced by nasal sensitization.
authors.affiliation: Department of Bacteriology, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-ku, Nagoya, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Minami
authors.affiliation: Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-Dori, Mizuho-ku, Nagoya, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Konishi
authors.affiliation: R&D Center, Kobayashi Pharmaceutical Co., Ltd., 4-10 Doshomachi 4-chome, Chuo-ku, Osaka, Japan.
authors.forename: Zhixia
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: R&D Center, Kobayashi Pharmaceutical Co., Ltd., 4-10 Doshomachi 4-chome, Chuo-ku, Osaka, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Arai
authors.affiliation: Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-Dori, Mizuho-ku, Nagoya, Japan.
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Makino
keywords: IgE; Interferon-γ; Interleukin-4; Passive cutaneous anaphylaxis reaction; Shin'iseihaito