title: Association of Autism Spectrum Disorder with Obsessive-Compulsive and Attention-Deficit/Hyperactivity Traits and Response Inhibition in a Community Sample.
abstract: We examined co-occurrence of autism spectrum disorder (ASD) with (traits of) attention-deficit/hyperactivity (ADHD), obsessive-compulsive (OCD) and inhibition deficits in a community sample (n = 16,676) and tested whether having a sibling with ASD manifested in increased features of ADHD, OCD or inhibition deficits. Individuals with ASD had increased ADHD and OCD traits compared with individuals without ASD. Individuals with a sibling with ASD exhibited more ADHD traits than did individuals whose sibling did not have ASD. The "sibling effect" on manifestation of ADHD traits was observed in individuals with and without ASD. Having a sibling with ASD did not affect OCD traits. Inhibition was impaired in individuals with ASD who had a sibling with ASD only.
authors.affiliation: Department of Psychiatry, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.|Department of Psychiatry, The University of Toronto, 250 College Street, Toronto, ON, M5T 1R8, Canada.
authors.forename: Ellen
authors.initials: E
authors.lastname: van der Plas
authors.affiliation: Department of Psychiatry, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.|Dalla Lana School of Public Health, The University of Toronto, 563 Spadina Crescent, Toronto, M5S 2J7, ON, Canada.
authors.forename: Annie
authors.initials: A
authors.lastname: Dupuis
authors.affiliation: Department of Psychiatry, The University of Toronto, 250 College Street, Toronto, ON, M5T 1R8, Canada.|Program in Genetics and Genome Biology, Peter Gilgan Centre for Research and Learning, 686 Bay Street, Toronto, ON, M5G 0A4, Canada.|The Mathison Centre for Mental Health Research and Education, The University of Calgary, 3280 Hospital Dr. NW, Calgary, AB, T2N 4Z6, Canada.
authors.forename: Paul
authors.initials: P
authors.lastname: Arnold
authors.affiliation: Department of Psychiatry, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Crosbie
authors.affiliation: Department of Psychiatry, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada. russell.schachar@sickkids.ca.|Department of Psychiatry, The University of Toronto, 250 College Street, Toronto, ON, M5T 1R8, Canada. russell.schachar@sickkids.ca.
authors.forename: Russell
authors.initials: R
authors.lastname: Schachar
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000503:physiopathology / Q000523:psychology*; D000067877:Autism Spectrum Disorder / Q000503:physiopathology / Q000523:psychology*; D002648:Child; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000503:physiopathology / Q000523:psychology*; D010641:Phenotype; D011597:Psychomotor Performance; D011930:Reaction Time; D035781:Siblings
keywords: Attention/deficits hyperactivity disorder; Autism; Community sample; Familial; Obsessive compulsive disorder; Traits