title: Right Unilateral Ultrabrief Pulse ECT in Geriatric Depression: Phase 1 of the PRIDE Study.
abstract: OBJECTIVE
  The Prolonging Remission in Depressed Elderly (PRIDE) study evaluated the efficacy of right unilateral ultrabrief pulse electroconvulsive therapy (ECT) combined with venlafaxine for the treatment of geriatric depression.
  
  
  METHODS
  PRIDE was a two-phase multisite study. Phase 1 was an acute course of right unilateral ultrabrief pulse ECT, combined with open-label venlafaxine at seven academic medical centers. In phase 2 (reported separately), patients who had remitted were randomly assigned to receive pharmacotherapy (venlafaxine plus lithium) or pharmacotherapy plus continuation ECT. In phase 1, depressed patients received high-dose ECT (at six times the seizure threshold) three times per week. Venlafaxine was started during the first week of treatment and continued throughout the study. The primary outcome measure was remission, assessed with the 24-item Hamilton Depression Rating Scale (HAM-D), which was administered three times per week. Secondary outcome measures were post-ECT reorientation and safety. Paired t tests were used to estimate and evaluate the significance of change from baseline in HAM-D scores.
  
  
  RESULTS
  Of 240 patients who entered phase 1 of the study, 172 completed it. Overall, 61.7% (148/240) of all patients met remission criteria, 10.0% (24/240) did not remit, and 28.3% (68/240) dropped out; 70% (169/240) met response criteria. Among those who remitted, the mean decrease in HAM-D score was 24.7 points (95% CI=23.4, 25.9), with a mean final score of 6.2 (SD=2.5) and an average change from baseline of 79%. The mean number of ECT treatments to remission was 7.3 (SD=3.1).
  
  
  CONCLUSIONS
  Right unilateral ultrabrief pulse ECT, combined with venlafaxine, is a rapidly acting and highly effective treatment option for depressed geriatric patients, with excellent safety and tolerability. These data add to the evidence base supporting the efficacy of ECT to treat severe depression in elderly patients.
authors.affiliation: From the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
authors.forename: Charles H
authors.initials: CH
authors.lastname: Kellner
authors.affiliation: From the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
authors.forename: Mustafa M
authors.initials: MM
authors.lastname: Husain
authors.affiliation: From the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
authors.forename: Rebecca G
authors.initials: RG
authors.lastname: Knapp
authors.affiliation: From the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
authors.forename: W Vaughn
authors.initials: WV
authors.lastname: McCall
authors.affiliation: From the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
authors.forename: Georgios
authors.initials: G
authors.lastname: Petrides
authors.affiliation: From the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
authors.forename: Matthew V
authors.initials: MV
authors.lastname: Rudorfer
authors.affiliation: From the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Young
authors.affiliation: From the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
authors.forename: Shirlene
authors.initials: S
authors.lastname: Sampson
authors.affiliation: From the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
authors.forename: Shawn M
authors.initials: SM
authors.lastname: McClintock
authors.affiliation: From the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
authors.forename: Martina
authors.initials: M
authors.lastname: Mueller
authors.affiliation: From the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
authors.forename: Joan
authors.initials: J
authors.lastname: Prudic
authors.affiliation: From the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Greenberg
authors.affiliation: From the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
authors.forename: Richard D
authors.initials: RD
authors.lastname: Weiner
authors.affiliation: From the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
authors.forename: Samuel H
authors.initials: SH
authors.lastname: Bailine
authors.affiliation: From the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
authors.forename: Peter B
authors.initials: PB
authors.lastname: Rosenquist
authors.affiliation: From the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Raza
authors.affiliation: From the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
authors.forename: Styliani
authors.initials: S
authors.lastname: Kaliora
authors.affiliation: From the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
authors.forename: Vassilios
authors.initials: V
authors.lastname: Latoussakis
authors.affiliation: From the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
authors.forename: Kristen G
authors.initials: KG
authors.lastname: Tobias
authors.affiliation: From the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
authors.forename: Mimi C
authors.initials: MC
authors.lastname: Briggs
authors.affiliation: From the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
authors.forename: Lauren S
authors.initials: LS
authors.lastname: Liebman
authors.affiliation: From the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
authors.forename: Emma T
authors.initials: ET
authors.lastname: Geduldig
authors.affiliation: From the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
authors.forename: Abeba A
authors.initials: AA
authors.lastname: Teklehaimanot
authors.affiliation: From the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
authors.forename: Sarah H
authors.initials: SH
authors.lastname: Lisanby
authors.affiliation: From the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use; D003131:Combined Modality Therapy / Q000379:methods; D003863:Depression / Q000188:drug therapy* / Q000628:therapy*; D004565:Electroconvulsive Therapy / Q000009:adverse effects / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D000069470:Venlafaxine Hydrochloride / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D018687:Antidepressive Agents, Second-Generation; D000069470:Venlafaxine Hydrochloride