title: [HTLV-1 bZIP Factor (HBZ): Roles in HTLV-1 Oncogenesis].
abstract: Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus demonstrated to be associated with human disease. Infection by the HTLV-1 can cause T-cell leukemia (ATL) in adults. HTLV-1 bZIP factor (HBZ) is a viral protein encoded by the minus strand of the HTLV-1 provirus. Among the regulatory and accessory genes of HTLV-1, HBZ is the only gene that remains intact and which is expressed consistently in all patients with ATL. Moreover, HBZ has a critical role in the leukemogenesis of ATL. Here, we review the function of HBZ in the oncogenesis of HTLV-1 and its molecular mechanism of action.
authors.forename: Wencai
authors.initials: W
authors.lastname: Wu
authors.forename: Wenzhao
authors.initials: W
authors.lastname: Cheng
authors.forename: Mengyun
authors.initials: M
authors.lastname: Chen
authors.forename: Lingling
authors.initials: L
authors.lastname: Xu
authors.forename: Tiejun
authors.initials: T
authors.lastname: Zhao
mesh_terms: D000818:Animals; D050976:Basic-Leucine Zipper Transcription Factors / Q000235:genetics / Q000378:metabolism*; D063646:Carcinogenesis; D015490:HTLV-I Infections / Q000473:pathology / Q000821:virology*; D015368:Human T-lymphotropic virus 1 / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D015458:Leukemia, T-Cell / Q000473:pathology / Q000821:virology*; D012191:Retroviridae Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D050976:Basic-Leucine Zipper Transcription Factors; C479751:HBZ protein, human T-cell leukemia virus type I; D012191:Retroviridae Proteins