title: Exploring structural features of folded peptide architectures in the construction of nanomaterials.
abstract: We are reporting the influence of foldamer structures on their self-assembled architectures. In a sharp contrast to the ordered α,γ-hybrid 12-helix obtained from 1 : 1 alternating Aib and γ-Phe, the α,γ-hybrid peptides constituted with α-Phe and 4,4-dimethyl γ-amino acid (Aic) displayed the extended sheet type of conformations in solution and spontaneously self-assembled into thermally and proteolytically stable capsules. In contrast, the conformationally ordered 12-helix self-assembled into a three-dimensional supramolecular polyhedron.
authors.affiliation: Department of Chemistry, Indian Institution of Science Education and Research, Dr. Homi Bhabha Road, Pune-411008, India. hn.gopi@iiserpune.ac.in.
authors.forename: Rajkumar
authors.initials: R
authors.lastname: Misra
authors.affiliation: Department of Chemistry, Indian Institution of Science Education and Research, Dr. Homi Bhabha Road, Pune-411008, India. hn.gopi@iiserpune.ac.in.
authors.forename: Rahi M
authors.initials: RM
authors.lastname: Reja
authors.affiliation: NMR Research Center, Indian Institute of Science, Bangalore-560012, India.
authors.forename: Lagumaddepalli V
authors.initials: LV
authors.lastname: Narendra
authors.affiliation: NMR Research Center, Indian Institute of Science, Bangalore-560012, India.
authors.forename: Gijo
authors.initials: G
authors.lastname: George
authors.affiliation: NMR Research Center, Indian Institute of Science, Bangalore-560012, India.
authors.forename: Srinivasarao
authors.initials: S
authors.lastname: Raghothama
authors.affiliation: Department of Chemistry, Indian Institution of Science Education and Research, Dr. Homi Bhabha Road, Pune-411008, India. hn.gopi@iiserpune.ac.in.
authors.forename: Hosahudya N
authors.initials: HN
authors.lastname: Gopi