title: Remote Intracerebral Hemorrhage After Intravenous Thrombolysis: Results From a Multicenter Study.
abstract: Remote parenchymal hemorrhage (rPH) after intravenous thrombolysis with recombinant tissue-type plasminogen activator may be associated with cerebral amyloid angiopathy, although supportive data are limited. We aimed to investigate risk factors of rPH after intravenous thrombolysis with recombinant tissue-type plasminogen activator.
  
  
  
  This is an observational study of patients with ischemic stroke who were treated with intravenous thrombolysis with recombinant tissue-type plasminogen activator and were included in a multicenter prospective registry. rPH was defined as any extraischemic hemorrhage detected in the follow-up computed tomography. We collected demographic, clinical, laboratory, radiological, and outcome variables. In the subset of patients who underwent a magnetic resonance imaging examination, we evaluated the distribution and burden of cerebral microbleeds, cortical superficial siderosis, leukoaraiosis, and recent silent ischemia in regions anatomically unrelated to the ischemic lesion that caused the initial symptoms. We compared patients with rPH with those without rPH or parenchymal hemorrhage. Independent risk factors for rPH were obtained by multivariable logistic regression analyses.
  
  
  
  We evaluated 992 patients (mean age, 74.0±12.6 years; 52.9% were men), and 408 (41%) of them underwent a magnetic resonance imaging. Twenty-six patients (2.6%) had a rPH, 8 (0.8%) had both rPH and PH, 58 (5.8%) had PH, and 900 (90.7%) had no bleeding complication. Lobar cerebral microbleeds (odds ratio, 8.0; 95% confidence interval, 2.3-27.2) and recent silent ischemia (odds ratio, 4.8; 95% confidence interval, 1.6-14.1) increased the risk of rPH.
  
  
  
  The occurrence of rPH after intravenous thrombolysis with recombinant tissue-type plasminogen activator in patients with ischemic stroke is associated with lobar cerebral microbleeds and multiple ischemic lesions in different regions.
authors.affiliation: From the Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute, IIB-Sant Pau, Barcelona, Spain (L.P.-S., P.C.-R., J.S.-F., R.D.-M., A.M.-D., R.M., J.M.-F.); Hospital Universitari Germans Trias i Pujol, Badalona, Spain (M.A., L.D., M.G.); Hospital Clínic de Barcelona, Barcelona, Spain (J.C., L.L.); Hospital del Mar, Barcelona, Spain (A.G.G., J.R.); Hospital Universitari Arnau de Vilanova, Lleida, Spain (F.P.); Hospital Moisès Broggi, Sant Joan Despí, Spain (M.G.-C.); Hospital Universitari de Sabadell-Corporació Sanitària Parc Taulí, Sabadell, Spain (D.C.); Hospital General Universitari de Granollers, Granollers, Spain (D.C.); Hospital Verge de la Cinta, Tortosa, Spain (M.G.); and Stroke Programme/Agency for Health Quality and Assessment of Catalonia, Barcelona, Spain (S.A.). lpratss@santpau.cat.
authors.forename: Luis
authors.initials: L
authors.lastname: Prats-Sánchez
authors.affiliation: From the Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute, IIB-Sant Pau, Barcelona, Spain (L.P.-S., P.C.-R., J.S.-F., R.D.-M., A.M.-D., R.M., J.M.-F.); Hospital Universitari Germans Trias i Pujol, Badalona, Spain (M.A., L.D., M.G.); Hospital Clínic de Barcelona, Barcelona, Spain (J.C., L.L.); Hospital del Mar, Barcelona, Spain (A.G.G., J.R.); Hospital Universitari Arnau de Vilanova, Lleida, Spain (F.P.); Hospital Moisès Broggi, Sant Joan Despí, Spain (M.G.-C.); Hospital Universitari de Sabadell-Corporació Sanitària Parc Taulí, Sabadell, Spain (D.C.); Hospital General Universitari de Granollers, Granollers, Spain (D.C.); Hospital Verge de la Cinta, Tortosa, Spain (M.G.); and Stroke Programme/Agency for Health Quality and Assessment of Catalonia, Barcelona, Spain (S.A.).
authors.forename: Pol
authors.initials: P
authors.lastname: Camps-Renom
authors.affiliation: From the Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute, IIB-Sant Pau, Barcelona, Spain (L.P.-S., P.C.-R., J.S.-F., R.D.-M., A.M.-D., R.M., J.M.-F.); Hospital Universitari Germans Trias i Pujol, Badalona, Spain (M.A., L.D., M.G.); Hospital Clínic de Barcelona, Barcelona, Spain (J.C., L.L.); Hospital del Mar, Barcelona, Spain (A.G.G., J.R.); Hospital Universitari Arnau de Vilanova, Lleida, Spain (F.P.); Hospital Moisès Broggi, Sant Joan Despí, Spain (M.G.-C.); Hospital Universitari de Sabadell-Corporació Sanitària Parc Taulí, Sabadell, Spain (D.C.); Hospital General Universitari de Granollers, Granollers, Spain (D.C.); Hospital Verge de la Cinta, Tortosa, Spain (M.G.); and Stroke Programme/Agency for Health Quality and Assessment of Catalonia, Barcelona, Spain (S.A.).
authors.forename: Javier
authors.initials: J
authors.lastname: Sotoca-Fernández
authors.affiliation: From the Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute, IIB-Sant Pau, Barcelona, Spain (L.P.-S., P.C.-R., J.S.-F., R.D.-M., A.M.-D., R.M., J.M.-F.); Hospital Universitari Germans Trias i Pujol, Badalona, Spain (M.A., L.D., M.G.); Hospital Clínic de Barcelona, Barcelona, Spain (J.C., L.L.); Hospital del Mar, Barcelona, Spain (A.G.G., J.R.); Hospital Universitari Arnau de Vilanova, Lleida, Spain (F.P.); Hospital Moisès Broggi, Sant Joan Despí, Spain (M.G.-C.); Hospital Universitari de Sabadell-Corporació Sanitària Parc Taulí, Sabadell, Spain (D.C.); Hospital General Universitari de Granollers, Granollers, Spain (D.C.); Hospital Verge de la Cinta, Tortosa, Spain (M.G.); and Stroke Programme/Agency for Health Quality and Assessment of Catalonia, Barcelona, Spain (S.A.).
authors.forename: Raquel
authors.initials: R
authors.lastname: Delgado-Mederos
authors.affiliation: From the Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute, IIB-Sant Pau, Barcelona, Spain (L.P.-S., P.C.-R., J.S.-F., R.D.-M., A.M.-D., R.M., J.M.-F.); Hospital Universitari Germans Trias i Pujol, Badalona, Spain (M.A., L.D., M.G.); Hospital Clínic de Barcelona, Barcelona, Spain (J.C., L.L.); Hospital del Mar, Barcelona, Spain (A.G.G., J.R.); Hospital Universitari Arnau de Vilanova, Lleida, Spain (F.P.); Hospital Moisès Broggi, Sant Joan Despí, Spain (M.G.-C.); Hospital Universitari de Sabadell-Corporació Sanitària Parc Taulí, Sabadell, Spain (D.C.); Hospital General Universitari de Granollers, Granollers, Spain (D.C.); Hospital Verge de la Cinta, Tortosa, Spain (M.G.); and Stroke Programme/Agency for Health Quality and Assessment of Catalonia, Barcelona, Spain (S.A.).
authors.forename: Alejandro
authors.initials: A
authors.lastname: Martínez-Domeño
authors.affiliation: From the Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute, IIB-Sant Pau, Barcelona, Spain (L.P.-S., P.C.-R., J.S.-F., R.D.-M., A.M.-D., R.M., J.M.-F.); Hospital Universitari Germans Trias i Pujol, Badalona, Spain (M.A., L.D., M.G.); Hospital Clínic de Barcelona, Barcelona, Spain (J.C., L.L.); Hospital del Mar, Barcelona, Spain (A.G.G., J.R.); Hospital Universitari Arnau de Vilanova, Lleida, Spain (F.P.); Hospital Moisès Broggi, Sant Joan Despí, Spain (M.G.-C.); Hospital Universitari de Sabadell-Corporació Sanitària Parc Taulí, Sabadell, Spain (D.C.); Hospital General Universitari de Granollers, Granollers, Spain (D.C.); Hospital Verge de la Cinta, Tortosa, Spain (M.G.); and Stroke Programme/Agency for Health Quality and Assessment of Catalonia, Barcelona, Spain (S.A.).
authors.forename: Rebeca
authors.initials: R
authors.lastname: Marín
authors.affiliation: From the Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute, IIB-Sant Pau, Barcelona, Spain (L.P.-S., P.C.-R., J.S.-F., R.D.-M., A.M.-D., R.M., J.M.-F.); Hospital Universitari Germans Trias i Pujol, Badalona, Spain (M.A., L.D., M.G.); Hospital Clínic de Barcelona, Barcelona, Spain (J.C., L.L.); Hospital del Mar, Barcelona, Spain (A.G.G., J.R.); Hospital Universitari Arnau de Vilanova, Lleida, Spain (F.P.); Hospital Moisès Broggi, Sant Joan Despí, Spain (M.G.-C.); Hospital Universitari de Sabadell-Corporació Sanitària Parc Taulí, Sabadell, Spain (D.C.); Hospital General Universitari de Granollers, Granollers, Spain (D.C.); Hospital Verge de la Cinta, Tortosa, Spain (M.G.); and Stroke Programme/Agency for Health Quality and Assessment of Catalonia, Barcelona, Spain (S.A.).
authors.forename: Miriam
authors.initials: M
authors.lastname: Almendrote
authors.affiliation: From the Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute, IIB-Sant Pau, Barcelona, Spain (L.P.-S., P.C.-R., J.S.-F., R.D.-M., A.M.-D., R.M., J.M.-F.); Hospital Universitari Germans Trias i Pujol, Badalona, Spain (M.A., L.D., M.G.); Hospital Clínic de Barcelona, Barcelona, Spain (J.C., L.L.); Hospital del Mar, Barcelona, Spain (A.G.G., J.R.); Hospital Universitari Arnau de Vilanova, Lleida, Spain (F.P.); Hospital Moisès Broggi, Sant Joan Despí, Spain (M.G.-C.); Hospital Universitari de Sabadell-Corporació Sanitària Parc Taulí, Sabadell, Spain (D.C.); Hospital General Universitari de Granollers, Granollers, Spain (D.C.); Hospital Verge de la Cinta, Tortosa, Spain (M.G.); and Stroke Programme/Agency for Health Quality and Assessment of Catalonia, Barcelona, Spain (S.A.).
authors.forename: Laura
authors.initials: L
authors.lastname: Dorado
authors.affiliation: From the Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute, IIB-Sant Pau, Barcelona, Spain (L.P.-S., P.C.-R., J.S.-F., R.D.-M., A.M.-D., R.M., J.M.-F.); Hospital Universitari Germans Trias i Pujol, Badalona, Spain (M.A., L.D., M.G.); Hospital Clínic de Barcelona, Barcelona, Spain (J.C., L.L.); Hospital del Mar, Barcelona, Spain (A.G.G., J.R.); Hospital Universitari Arnau de Vilanova, Lleida, Spain (F.P.); Hospital Moisès Broggi, Sant Joan Despí, Spain (M.G.-C.); Hospital Universitari de Sabadell-Corporació Sanitària Parc Taulí, Sabadell, Spain (D.C.); Hospital General Universitari de Granollers, Granollers, Spain (D.C.); Hospital Verge de la Cinta, Tortosa, Spain (M.G.); and Stroke Programme/Agency for Health Quality and Assessment of Catalonia, Barcelona, Spain (S.A.).
authors.forename: Meritxell
authors.initials: M
authors.lastname: Gomis
authors.affiliation: From the Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute, IIB-Sant Pau, Barcelona, Spain (L.P.-S., P.C.-R., J.S.-F., R.D.-M., A.M.-D., R.M., J.M.-F.); Hospital Universitari Germans Trias i Pujol, Badalona, Spain (M.A., L.D., M.G.); Hospital Clínic de Barcelona, Barcelona, Spain (J.C., L.L.); Hospital del Mar, Barcelona, Spain (A.G.G., J.R.); Hospital Universitari Arnau de Vilanova, Lleida, Spain (F.P.); Hospital Moisès Broggi, Sant Joan Despí, Spain (M.G.-C.); Hospital Universitari de Sabadell-Corporació Sanitària Parc Taulí, Sabadell, Spain (D.C.); Hospital General Universitari de Granollers, Granollers, Spain (D.C.); Hospital Verge de la Cinta, Tortosa, Spain (M.G.); and Stroke Programme/Agency for Health Quality and Assessment of Catalonia, Barcelona, Spain (S.A.).
authors.forename: Javier
authors.initials: J
authors.lastname: Codas
authors.affiliation: From the Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute, IIB-Sant Pau, Barcelona, Spain (L.P.-S., P.C.-R., J.S.-F., R.D.-M., A.M.-D., R.M., J.M.-F.); Hospital Universitari Germans Trias i Pujol, Badalona, Spain (M.A., L.D., M.G.); Hospital Clínic de Barcelona, Barcelona, Spain (J.C., L.L.); Hospital del Mar, Barcelona, Spain (A.G.G., J.R.); Hospital Universitari Arnau de Vilanova, Lleida, Spain (F.P.); Hospital Moisès Broggi, Sant Joan Despí, Spain (M.G.-C.); Hospital Universitari de Sabadell-Corporació Sanitària Parc Taulí, Sabadell, Spain (D.C.); Hospital General Universitari de Granollers, Granollers, Spain (D.C.); Hospital Verge de la Cinta, Tortosa, Spain (M.G.); and Stroke Programme/Agency for Health Quality and Assessment of Catalonia, Barcelona, Spain (S.A.).
authors.forename: Laura
authors.initials: L
authors.lastname: Llull
authors.affiliation: From the Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute, IIB-Sant Pau, Barcelona, Spain (L.P.-S., P.C.-R., J.S.-F., R.D.-M., A.M.-D., R.M., J.M.-F.); Hospital Universitari Germans Trias i Pujol, Badalona, Spain (M.A., L.D., M.G.); Hospital Clínic de Barcelona, Barcelona, Spain (J.C., L.L.); Hospital del Mar, Barcelona, Spain (A.G.G., J.R.); Hospital Universitari Arnau de Vilanova, Lleida, Spain (F.P.); Hospital Moisès Broggi, Sant Joan Despí, Spain (M.G.-C.); Hospital Universitari de Sabadell-Corporació Sanitària Parc Taulí, Sabadell, Spain (D.C.); Hospital General Universitari de Granollers, Granollers, Spain (D.C.); Hospital Verge de la Cinta, Tortosa, Spain (M.G.); and Stroke Programme/Agency for Health Quality and Assessment of Catalonia, Barcelona, Spain (S.A.).
authors.forename: Alejandra
authors.initials: A
authors.lastname: Gómez González
authors.affiliation: From the Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute, IIB-Sant Pau, Barcelona, Spain (L.P.-S., P.C.-R., J.S.-F., R.D.-M., A.M.-D., R.M., J.M.-F.); Hospital Universitari Germans Trias i Pujol, Badalona, Spain (M.A., L.D., M.G.); Hospital Clínic de Barcelona, Barcelona, Spain (J.C., L.L.); Hospital del Mar, Barcelona, Spain (A.G.G., J.R.); Hospital Universitari Arnau de Vilanova, Lleida, Spain (F.P.); Hospital Moisès Broggi, Sant Joan Despí, Spain (M.G.-C.); Hospital Universitari de Sabadell-Corporació Sanitària Parc Taulí, Sabadell, Spain (D.C.); Hospital General Universitari de Granollers, Granollers, Spain (D.C.); Hospital Verge de la Cinta, Tortosa, Spain (M.G.); and Stroke Programme/Agency for Health Quality and Assessment of Catalonia, Barcelona, Spain (S.A.).
authors.forename: Jaume
authors.initials: J
authors.lastname: Roquer
authors.affiliation: From the Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute, IIB-Sant Pau, Barcelona, Spain (L.P.-S., P.C.-R., J.S.-F., R.D.-M., A.M.-D., R.M., J.M.-F.); Hospital Universitari Germans Trias i Pujol, Badalona, Spain (M.A., L.D., M.G.); Hospital Clínic de Barcelona, Barcelona, Spain (J.C., L.L.); Hospital del Mar, Barcelona, Spain (A.G.G., J.R.); Hospital Universitari Arnau de Vilanova, Lleida, Spain (F.P.); Hospital Moisès Broggi, Sant Joan Despí, Spain (M.G.-C.); Hospital Universitari de Sabadell-Corporació Sanitària Parc Taulí, Sabadell, Spain (D.C.); Hospital General Universitari de Granollers, Granollers, Spain (D.C.); Hospital Verge de la Cinta, Tortosa, Spain (M.G.); and Stroke Programme/Agency for Health Quality and Assessment of Catalonia, Barcelona, Spain (S.A.).
authors.forename: Francisco
authors.initials: F
authors.lastname: Purroy
authors.affiliation: From the Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute, IIB-Sant Pau, Barcelona, Spain (L.P.-S., P.C.-R., J.S.-F., R.D.-M., A.M.-D., R.M., J.M.-F.); Hospital Universitari Germans Trias i Pujol, Badalona, Spain (M.A., L.D., M.G.); Hospital Clínic de Barcelona, Barcelona, Spain (J.C., L.L.); Hospital del Mar, Barcelona, Spain (A.G.G., J.R.); Hospital Universitari Arnau de Vilanova, Lleida, Spain (F.P.); Hospital Moisès Broggi, Sant Joan Despí, Spain (M.G.-C.); Hospital Universitari de Sabadell-Corporació Sanitària Parc Taulí, Sabadell, Spain (D.C.); Hospital General Universitari de Granollers, Granollers, Spain (D.C.); Hospital Verge de la Cinta, Tortosa, Spain (M.G.); and Stroke Programme/Agency for Health Quality and Assessment of Catalonia, Barcelona, Spain (S.A.).
authors.forename: Manuel
authors.initials: M
authors.lastname: Gómez-Choco
authors.affiliation: From the Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute, IIB-Sant Pau, Barcelona, Spain (L.P.-S., P.C.-R., J.S.-F., R.D.-M., A.M.-D., R.M., J.M.-F.); Hospital Universitari Germans Trias i Pujol, Badalona, Spain (M.A., L.D., M.G.); Hospital Clínic de Barcelona, Barcelona, Spain (J.C., L.L.); Hospital del Mar, Barcelona, Spain (A.G.G., J.R.); Hospital Universitari Arnau de Vilanova, Lleida, Spain (F.P.); Hospital Moisès Broggi, Sant Joan Despí, Spain (M.G.-C.); Hospital Universitari de Sabadell-Corporació Sanitària Parc Taulí, Sabadell, Spain (D.C.); Hospital General Universitari de Granollers, Granollers, Spain (D.C.); Hospital Verge de la Cinta, Tortosa, Spain (M.G.); and Stroke Programme/Agency for Health Quality and Assessment of Catalonia, Barcelona, Spain (S.A.).
authors.forename: David
authors.initials: D
authors.lastname: Cánovas
authors.affiliation: From the Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute, IIB-Sant Pau, Barcelona, Spain (L.P.-S., P.C.-R., J.S.-F., R.D.-M., A.M.-D., R.M., J.M.-F.); Hospital Universitari Germans Trias i Pujol, Badalona, Spain (M.A., L.D., M.G.); Hospital Clínic de Barcelona, Barcelona, Spain (J.C., L.L.); Hospital del Mar, Barcelona, Spain (A.G.G., J.R.); Hospital Universitari Arnau de Vilanova, Lleida, Spain (F.P.); Hospital Moisès Broggi, Sant Joan Despí, Spain (M.G.-C.); Hospital Universitari de Sabadell-Corporació Sanitària Parc Taulí, Sabadell, Spain (D.C.); Hospital General Universitari de Granollers, Granollers, Spain (D.C.); Hospital Verge de la Cinta, Tortosa, Spain (M.G.); and Stroke Programme/Agency for Health Quality and Assessment of Catalonia, Barcelona, Spain (S.A.).
authors.forename: Dolores
authors.initials: D
authors.lastname: Cocho
authors.affiliation: From the Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute, IIB-Sant Pau, Barcelona, Spain (L.P.-S., P.C.-R., J.S.-F., R.D.-M., A.M.-D., R.M., J.M.-F.); Hospital Universitari Germans Trias i Pujol, Badalona, Spain (M.A., L.D., M.G.); Hospital Clínic de Barcelona, Barcelona, Spain (J.C., L.L.); Hospital del Mar, Barcelona, Spain (A.G.G., J.R.); Hospital Universitari Arnau de Vilanova, Lleida, Spain (F.P.); Hospital Moisès Broggi, Sant Joan Despí, Spain (M.G.-C.); Hospital Universitari de Sabadell-Corporació Sanitària Parc Taulí, Sabadell, Spain (D.C.); Hospital General Universitari de Granollers, Granollers, Spain (D.C.); Hospital Verge de la Cinta, Tortosa, Spain (M.G.); and Stroke Programme/Agency for Health Quality and Assessment of Catalonia, Barcelona, Spain (S.A.).
authors.forename: Moises
authors.initials: M
authors.lastname: Garces
authors.affiliation: From the Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute, IIB-Sant Pau, Barcelona, Spain (L.P.-S., P.C.-R., J.S.-F., R.D.-M., A.M.-D., R.M., J.M.-F.); Hospital Universitari Germans Trias i Pujol, Badalona, Spain (M.A., L.D., M.G.); Hospital Clínic de Barcelona, Barcelona, Spain (J.C., L.L.); Hospital del Mar, Barcelona, Spain (A.G.G., J.R.); Hospital Universitari Arnau de Vilanova, Lleida, Spain (F.P.); Hospital Moisès Broggi, Sant Joan Despí, Spain (M.G.-C.); Hospital Universitari de Sabadell-Corporació Sanitària Parc Taulí, Sabadell, Spain (D.C.); Hospital General Universitari de Granollers, Granollers, Spain (D.C.); Hospital Verge de la Cinta, Tortosa, Spain (M.G.); and Stroke Programme/Agency for Health Quality and Assessment of Catalonia, Barcelona, Spain (S.A.).
authors.forename: Sonia
authors.initials: S
authors.lastname: Abilleira
authors.affiliation: From the Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute, IIB-Sant Pau, Barcelona, Spain (L.P.-S., P.C.-R., J.S.-F., R.D.-M., A.M.-D., R.M., J.M.-F.); Hospital Universitari Germans Trias i Pujol, Badalona, Spain (M.A., L.D., M.G.); Hospital Clínic de Barcelona, Barcelona, Spain (J.C., L.L.); Hospital del Mar, Barcelona, Spain (A.G.G., J.R.); Hospital Universitari Arnau de Vilanova, Lleida, Spain (F.P.); Hospital Moisès Broggi, Sant Joan Despí, Spain (M.G.-C.); Hospital Universitari de Sabadell-Corporació Sanitària Parc Taulí, Sabadell, Spain (D.C.); Hospital General Universitari de Granollers, Granollers, Spain (D.C.); Hospital Verge de la Cinta, Tortosa, Spain (M.G.); and Stroke Programme/Agency for Health Quality and Assessment of Catalonia, Barcelona, Spain (S.A.).
authors.forename: Joan
authors.initials: J
authors.lastname: Martí-Fàbregas
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000000981:diagnostic imaging*; D002545:Brain Ischemia / Q000000981:diagnostic imaging / Q000188:drug therapy*; D016657:Cerebral Amyloid Angiopathy / Q000000981:diagnostic imaging*; D002543:Cerebral Hemorrhage / Q000139:chemically induced*; D005260:Female; D005343:Fibrinolytic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012042:Registries; D012307:Risk Factors; D020521:Stroke / Q000000981:diagnostic imaging / Q000188:drug therapy*; D010959:Tissue Plasminogen Activator / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator
keywords: amyloid; cerebral amyloid angiopathy; cerebral hemorrhage; stroke; thrombolytic therapy