title: Abnormal EEG Complexity and Functional Connectivity of Brain in Patients with Acute Thalamic Ischemic Stroke.
abstract: Ischemic thalamus stroke has become a serious cardiovascular and cerebral disease in recent years. To date the existing researches mostly concentrated on the power spectral density (PSD) in several frequency bands. In this paper, we investigated the nonlinear features of EEG and brain functional connectivity in patients with acute thalamic ischemic stroke and healthy subjects. Electroencephalography (EEG) in resting condition with eyes closed was recorded for 12 stroke patients and 11 healthy subjects as control group. Lempel-Ziv complexity (LZC), Sample Entropy (SampEn), and brain network using partial directed coherence (PDC) were calculated for feature extraction. Results showed that patients had increased mean LZC and SampEn than the controls, which implied the stroke group has higher EEG complexity. For the brain network, the stroke group displayed a trend of weaker cortical connectivity, which suggests a functional impairment of information transmission in cortical connections in stroke patients. These findings suggest that nonlinear analysis and brain network could provide essential information for better understanding the brain dysfunction in the stroke and assisting monitoring or prognostication of stroke evolution.
authors.affiliation: Neural Engineering & Rehabilitation Lab, Department of Biomedical Engineering, College of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Neurology, Tianjin First Center Hospital, Tianjin 300072, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Guo
authors.affiliation: Neural Engineering & Rehabilitation Lab, Department of Biomedical Engineering, College of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China.
authors.forename: Jiayuan
authors.initials: J
authors.lastname: Meng
authors.affiliation: Department of Neurology, Tianjin First Center Hospital, Tianjin 300072, China.
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Neurology, Tianjin First Center Hospital, Tianjin 300072, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yao
authors.affiliation: Neural Engineering & Rehabilitation Lab, Department of Biomedical Engineering, College of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China.
authors.forename: Jiajia
authors.initials: J
authors.lastname: Yang
authors.affiliation: Neural Engineering & Rehabilitation Lab, Department of Biomedical Engineering, College of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China.
authors.forename: Hongzhi
authors.initials: H
authors.lastname: Qi
authors.affiliation: Neural Engineering & Rehabilitation Lab, Department of Biomedical Engineering, College of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Ming
mesh_terms: D000208:Acute Disease; D000368:Aged; D000465:Algorithms; D001921:Brain / Q000000981:diagnostic imaging*; D002545:Brain Ischemia / Q000000981:diagnostic imaging*; D001931:Brain Mapping; D016022:Case-Control Studies; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D017711:Nonlinear Dynamics; D011336:Probability; D011379:Prognosis; D020521:Stroke / Q000000981:diagnostic imaging*; D013788:Thalamus / Q000503:physiopathology