title: Does Infection During Pregnancy Outside of the Time of Delivery Increase the Risk of Cerebral Palsy?
abstract: ObjectiveWe sought to evaluate whether maternal antepartum infection (excluding chorioamnionitis) is associated with cerebral palsy (CP).Study DesignThis is a secondary analysis from a multicenter trial in women at risk of preterm delivery who received antenatal magnesium sulfate versus placebo. We compared the risk of CP in the children of women who had evidence of antepartum infection over the course of pregnancy to those women who had no evidence of antepartum infection during pregnancy.ResultsWithin a cohort of 2,251 women who met our inclusion criteria, 1,350 women had no history of infection in pregnancy and 801 women had a history of some type of antepartum infection during pregnancy. The incidence of CP was similar between the two groups (4.9 vs 5.0%;p= 0.917). After adjustment for maternal and obstetric confounders, we observed no significantly increased risk of CP among infants born to women with evidence of antepartum infection; (adjusted relative risk [aRR], 1.09 (0.72, 1.66);p= 0.68).ConclusionCompared with women with no evidence of antepartum infection during pregnancy, those women with infections excluding chorioamnionitis may not be at an increased risk of delivering an infant with CP.
authors.affiliation: Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon.
authors.forename: Kathleen F
authors.initials: KF
authors.lastname: Brookfield
authors.affiliation: Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Nashville, Tennessee.
authors.forename: Sarah S
authors.initials: SS
authors.lastname: Osmundson
authors.affiliation: Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon.
authors.forename: Aaron B
authors.initials: AB
authors.lastname: Caughey
authors.affiliation: Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon.
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Snowden
mesh_terms: D000328:Adult; D002547:Cerebral Palsy / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology*; D047928:Premature Birth / Q000453:epidemiology; D016032:Randomized Controlled Trials as Topic; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult