title: Improving the outcome of fractional CO2 laser resurfacing using a probiotic skin cream: Preliminary clinical evaluation.
abstract: As known, fractional CO2resurfacing treatments are more effective than non-ablative ones against aging signs, but post-operative redness and swelling prolong the overall downtime requiring up to steroid administration in order to reduce these local systems. In the last years, an increasing interest has been focused on the possible use of probiotics for treating inflammatory and allergic conditions suggesting that they can exert profound beneficial effects on skin homeostasis. In this work, the Authors report their experience on fractional CO2laser resurfacing and provide the results of a new post-operative topical treatment with an experimental cream containing probiotic-derived active principles potentially able to modulate the inflammatory reaction associated to laser-treatment. The cream containing DermaACB (CERABEST™) was administered post-operatively to 42 consecutive patients who were treated with fractional CO2laser. All patients adopted the cream twice a day for 2 weeks. Grades were given according to outcome scale. The efficacy of the cream containing DermaACB was evaluated comparing the rate of post-operative signs vanishing with a control group of 20 patients topically treated with an antibiotic cream and a hyaluronic acid based cream. Results registered with the experimental treatment were good in 22 patients, moderate in 17, and poor in 3 cases. Patients using the study cream took an average time of 14.3 days for erythema resolution and 9.3 days for swelling vanishing. The post-operative administration of the cream containing DermaACB induces a quicker reduction of post-operative erythema and swelling when compared to a standard treatment.
authors.affiliation: Department of Life, Health & Enviromental Sciences, Plastic and Reconstructive Surgery Section, University of L'Aquila, 67100, L'Aquila, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Zoccali
authors.affiliation: Department of Life, Health & Enviromental Sciences, Immunopathology Section, University of L'Aquila, 67100, L'Aquila, Italy.
authors.forename: Benedetta
authors.initials: B
authors.lastname: Cinque
authors.affiliation: Department of Life, Health & Enviromental Sciences, Immunopathology Section, University of L'Aquila, 67100, L'Aquila, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: La Torre
authors.affiliation: Department of Life, Health & Enviromental Sciences, Immunopathology Section, University of L'Aquila, 67100, L'Aquila, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Lombardi
authors.affiliation: Department of Life, Health & Enviromental Sciences, Immunopathology Section, University of L'Aquila, 67100, L'Aquila, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Palumbo
authors.affiliation: Department of Life, Health & Enviromental Sciences, Plastic and Reconstructive Surgery Section, University of L'Aquila, 67100, L'Aquila, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Romano
authors.affiliation: Department of Life, Health & Enviromental Sciences, Statistics and Epidemiology Section, University of L'Aquila, 67100, L'Aquila, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Mattei
authors.affiliation: Department of Life, Health & Enviromental Sciences, Plastic and Reconstructive Surgery Section, University of L'Aquila, 67100, L'Aquila, Italy.
authors.forename: Gino
authors.initials: G
authors.lastname: Orsini
authors.affiliation: Department of Life, Health & Enviromental Sciences, Immunopathology Section, University of L'Aquila, 67100, L'Aquila, Italy.
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Cifone
authors.affiliation: Department of Life, Health & Enviromental Sciences, Plastic and Reconstructive Surgery Section, University of L'Aquila, 67100, L'Aquila, Italy. maurizio.giuliani@cc.univaq.it.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Giuliani
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D004487:Edema / Q000188:drug therapy / Q000209:etiology; D004890:Erythema / Q000188:drug therapy / Q000209:etiology; D005260:Female; D006801:Humans; D053685:Laser Therapy / Q000009:adverse effects; D054020:Lasers, Gas / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D019936:Probiotics / Q000008:administration & dosage*; D012060:Rejuvenation; D012867:Skin; D063465:Skin Cream / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents
keywords: CO2 laser; Fractional resurfacing; Inflammatory reaction; Probiotics