title: [Principles of adoptive cell therapy based on "Tumor Infiltrating Lymphocytes"].
abstract: Adoptive cell therapy consists in the use of T lymphocytes for therapeutic purposes. Up to now, of limited use in clinical practice for logistical reasons, technical progress and substantial level of evidence obtained in the last decade allow its arrival in universitary hospitals. We will principally discuss the administration of expanded tumor infiltrating T cells in the treatment of metastatic melanoma. This treatment modality exploits the natural specificity of these cells and aims to potentiate their effectiveness. This personalized immunotherapy detains a potential for expansion to many other advanced tumor types.
authors.forename: Filipe
authors.initials: F
authors.lastname: Martins
authors.forename: Angela
authors.initials: A
authors.lastname: Orcurto
authors.forename: Olivier
authors.initials: O
authors.lastname: Michielin
authors.forename: George
authors.initials: G
authors.lastname: Coukos
mesh_terms: D006801:Humans; D016219:Immunotherapy, Adoptive / Q000379:methods*; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology*; D008545:Melanoma / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D009362:Neoplasm Metastasis; D057285:Precision Medicine; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology / Q000628:therapy