title: Antiproliferative Properties of Oleuropein in Human Osteosarcoma Cells.
abstract: In this study, we evaluated the antiproliferative activity on two human osteosarcoma cell lines (MG-63 and Saos2) of oleuropein, an olive oil compound traditionally found in the Mediterranean diet. Oleuropein exhibited obvious cytotoxic effects on human osteosarcoma cells in a concentration- and time-dependent manner. Statistical analysis of IC50 by the Probit regression method suggested that oleuropein had similar toxic effects on both cell lines tested (IC50 range from 247.4-475.0 µM for MG63 cells and from 798.7-359.9 µM for Saos2 cells).
authors.forename: Jose M
authors.initials: JM
authors.lastname: Morana
authors.forename: Olga
authors.initials: O
authors.lastname: Leal-Hernande
authors.forename: Maria L
authors.initials: ML
authors.lastname: Canal-Macías
authors.forename: Raul
authors.initials: R
authors.lastname: Roncero-Martin
authors.forename: Rafael
authors.initials: R
authors.lastname: Guerrero-Bonmatty
authors.forename: Ignacio
authors.initials: I
authors.lastname: Aliaga
authors.forename: Juan D Pedrera
authors.initials: JD
authors.lastname: Zamorano
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D057888:Iridoid Glucosides; D039823:Iridoids / Q000494:pharmacology / Q000627:therapeutic use*; D012516:Osteosarcoma / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D057888:Iridoid Glucosides; D039823:Iridoids; D010936:Plant Extracts; C002769:oleuropein