title: Bio-/Chemosensors and Imaging with Aggregation-Induced Emission Luminogens.
abstract: Aggregation-induced emission (AIE) luminogens show abnormal fluorescent behavior; they are non-emissive in solution, but they become strongly emissive after aggregation. Sensing and imaging are the major applications of AIE luminogens. By properly manipulating the aggregation and deaggregation of AIE molecules, various bio-/chemosensors have been developed. Moreover, AIE molecules with targeting groups have been devised for imaging of organelles and cancer cells. In this account, we report our recent work on the application of AIE luminogens for the construction of bio-/chemosensors and imaging.
authors.affiliation: Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic Solids, Institute of Chemistry Chinese Academy of Sciences, Beijing, 100190, P. R. China.|University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
authors.forename: Chi
authors.initials: C
authors.lastname: Zhan
authors.affiliation: Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic Solids, Institute of Chemistry Chinese Academy of Sciences, Beijing, 100190, P. R. China.|University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
authors.forename: Xue
authors.initials: X
authors.lastname: You
authors.affiliation: Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic Solids, Institute of Chemistry Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Guanxin
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic Solids, Institute of Chemistry Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Deqing
authors.initials: D
authors.lastname: Zhang
mesh_terms: D000818:Animals; D015374:Biosensing Techniques; D004277:DNA, Single-Stranded / Q000032:analysis; D005456:Fluorescent Dyes / Q000737:chemistry*; D054856:G-Quadruplexes; D006801:Humans; D007211:Indoles / Q000737:chemistry*; D049449:Luminescence; D008670:Metals / Q000032:analysis; D057054:Molecular Imaging / Q000379:methods*; D009369:Neoplasms / Q000000981:diagnostic imaging; D015388:Organelles / Q000378:metabolism; D017646:Organosilicon Compounds / Q000737:chemistry*; D011506:Proteins / Q000032:analysis; D013267:Stilbenes / Q000737:chemistry
chemical_list: D004277:DNA, Single-Stranded; D005456:Fluorescent Dyes; D007211:Indoles; D008670:Metals; D017646:Organosilicon Compounds; D011506:Proteins; D013267:Stilbenes; C000617116:tetraphenylethylene
keywords: aggregation; biosensors; chemosensors; fluorescent probes; imaging agents