title: MicroRNAs in regulation of osteogenic differentiation of mesenchymal stem cells.
abstract: Mesenchymal stem cells (MSCs), also referred to as multipotent stromal cells, have been isolated from various adult tissue sources because of their capabilities of differentiating into multiple cell lineages including osteoblasts, thus providing a novel approach for treating bone diseases and metabolic disorders. Despite extensive potential in cell therapy and widespread interest in clinical applications of MSCs, the molecular mechanisms with regard to the regulation of their therapeutic properties and osteoblast differentiation remain to be fully elucidated. MicroRNAs (miRNAs), a novel class of endogenous small noncoding RNAs, regulate gene expressions by translational repression or degradation of their targets. Recently, emerging evidence has shown that miRNAs are closely involved in controlling the key steps of osteoblast differentiation in MSCs. This review focuses on miRNAs and their roles in regulating osteogenic differentiation of MSCs.
authors.affiliation: Key Laboratory of Swine Genetics and Breeding of Agricultural Ministry, College of Animal Science and Technology, Huazhong Agricultural University, No.1 Shizishan Street, Wuhan, Hubei, 430070, China.|The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China.
authors.forename: Cong
authors.initials: C
authors.lastname: Huang
authors.affiliation: Key Laboratory of Swine Genetics and Breeding of Agricultural Ministry, College of Animal Science and Technology, Huazhong Agricultural University, No.1 Shizishan Street, Wuhan, Hubei, 430070, China.|The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China.
authors.forename: Junnan
authors.initials: J
authors.lastname: Geng
authors.affiliation: Key Laboratory of Swine Genetics and Breeding of Agricultural Ministry, College of Animal Science and Technology, Huazhong Agricultural University, No.1 Shizishan Street, Wuhan, Hubei, 430070, China. jiangsiwen@mail.hzau.edu.cn.|The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China. jiangsiwen@mail.hzau.edu.cn.
authors.forename: Siwen
authors.initials: S
authors.lastname: Jiang
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics*; D000066673:Cell Self Renewal / Q000235:genetics; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000378:metabolism*; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D010012:Osteogenesis / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics
chemical_list: D035683:MicroRNAs
keywords: Mesenchymal stem cells; Osteogenesis; Signaling pathways; Transcription factors; microRNAs