title: New developments in the clinical use of drug-coated balloon catheters in peripheral arterial disease.
abstract: Peripheral arterial disease (PAD) involving the lower extremity is a major source of morbidity and mortality. Clinical manifestations of PAD span the spectrum from lifestyle limiting claudication to ulceration and gangrene leading to amputation. Advancements including balloon angioplasty, self-expanding stents, drug-eluting stents, and atherectomy have resulted in high technical success rates for endovascular therapy in patients with PAD. However, these advances have been limited by somewhat high rates of clinical restenosis and clinically driven target lesion revascularization. The recent introduction of drug-coated balloon technology shows promise in limiting neointimal hyperplasia induced by vascular injury after endovascular therapies. This review summarizes the contemporary clinical data in the emerging area of drug-coated balloons.
authors.affiliation: Division of Cardiovascular Medicine, Sulpizio Cardiovascular Center, University of California, San Diego, CA, USA.
authors.forename: Jesse
authors.initials: J
authors.lastname: Naghi
authors.affiliation: Division of Cardiovascular Medicine, Sulpizio Cardiovascular Center, University of California, San Diego, CA, USA.
authors.forename: Ethan A
authors.initials: EA
authors.lastname: Yalvac
authors.affiliation: Division of Cardiovascular Medicine, Sulpizio Cardiovascular Center, University of California, San Diego, CA, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Pourdjabbar
authors.affiliation: Division of Cardiovascular Medicine, Sulpizio Cardiovascular Center, University of California, San Diego, CA, USA.
authors.forename: Lawrence
authors.initials: L
authors.lastname: Ang
authors.affiliation: Division of Cardiovascular Medicine, Sulpizio Cardiovascular Center, University of California, San Diego, CA, USA.
authors.forename: John
authors.initials: J
authors.lastname: Bahadorani
authors.affiliation: Division of Cardiovascular Medicine, Sulpizio Cardiovascular Center, University of California, San Diego, CA, USA.
authors.forename: Ryan R
authors.initials: RR
authors.lastname: Reeves
authors.affiliation: Division of Cardiovascular Medicine, Sulpizio Cardiovascular Center, University of California, San Diego, CA, USA.
authors.forename: Ehtisham
authors.initials: E
authors.lastname: Mahmud
authors.affiliation: Division of Cardiovascular Medicine, Sulpizio Cardiovascular Center, University of California, San Diego, CA, USA.
authors.forename: Mitul
authors.initials: M
authors.lastname: Patel
keywords: drug-coated balloons; endovascular; paclitaxel; percutaneous transluminal angioplasty; peripheral arterial disease