title: Non-cosmetic dermatological uses of botulinum neurotoxin.
abstract: Botulinum neurotoxin (BoNT) is renowned for its inhibitory effects on the neuromuscular junction. The evidence for its use in cosmetic dermatology and in non-dermatological indications is well established. We have systemically analysed the evidence for the non-cosmetic dermatological uses of BoNT. This review presents the many small studies showing promising results for the use of BoNT in a multitude of dermatological diseases, including (but not limited to) hyperhidrosis, Darier's disease, Hailey-Hailey disease, pompholyx and hidradenitis suppurativa. There is, however, the need for larger, double-blinded randomized control trials against established treatments to cement the evidence base underlying the use of BoNT in dermatology.
authors.affiliation: King Edward VII Hospital, London, UK.
authors.forename: E
authors.initials: E
authors.lastname: Forbat
authors.affiliation: Dermatological Surgery & Laser Unit, St John's Institute of Dermatology, St Thomas' Hospital, London, UK.
authors.forename: F R
authors.initials: FR
authors.lastname: Ali
authors.affiliation: Dermatological Surgery & Laser Unit, St John's Institute of Dermatology, St Thomas' Hospital, London, UK.
authors.forename: F
authors.initials: F
authors.lastname: Al-Niaimi
mesh_terms: D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D006801:Humans; D012871:Skin Diseases / Q000145:classification / Q000188:drug therapy*
chemical_list: D019274:Botulinum Toxins, Type A