title: Gene- gene interaction between CYP2J2 and PPAR -γ gene on late-onset Alzheimer's disease in the eastern Chinese Han population.
abstract: To investigate the impact of PPAR -γ and CYP2J2 gene single nucleotide polymorphisms (SNPs) and gene- gene interactions on late-onset Alzheimer's disease (LOAD) risk in Chinese Han population.
  
  
  
  A total of 880 participants (514 males, 366 females), with a mean age of 81.7±15.9years old are selected, including 430 LOAD patients and 450 normal participants. Generalized multifactor dimensionality reduction (GMDR) is used to examine interaction among six SNPs, odds ratio (OR) and 95% confident interval (95%CI) are calculated by Logistic regression model.
  
  
  
  Logistic regression analysis showed that increased LOAD risks are associated with T allele of the rs1155002 polymorphism, adjusted OR (95%CI)=1.46 (1.12-1.90), and T allele of the rs890293 polymorphism, adjusted OR (95%CI)=1.65 (1.30-2.06), and G allele of the rs1805192 polymorphism, adjusted OR (95%CI)=1.70 (1.25-2.27). We also found a potential gene-gene interaction between rs890293 and rs1805192. Participants with GT or TT of rs890293 and CG or GG of rs1805192 genotype have the highest LOAD risk, compared to participants with GG of rs890293 and CC of rs1805192 genotype, OR (95%CI)=2.22 (1.63 -2.85), after covariates adjustment.
  
  
  
  rs1155002, rs890293 and rs1805192 polymorphism are associated with increased LOAD risk. Participants with GT or TT of rs890293 and CG or GG of rs1805192 genotype have the highest LOAD risk.
authors.affiliation: Department of Neurology, PLA 148 Hospital, Zi bo, Shandong, 255300, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Geng
authors.affiliation: School of Medicine of Henan University, Kaifeng, Henan, 475001, China.
authors.forename: Yutong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: School of Medicine of Henan University, Kaifeng, Henan, 475001, China.
authors.forename: Yongmei
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Neurology, PLA 148 Hospital, Zi bo, Shandong, 255300, China.
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Neurology, PLA 148 Hospital, Zi bo, Shandong, 255300, China.
authors.forename: Honglei
authors.initials: H
authors.lastname: Yin
authors.affiliation: Department of Neurology, Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450014, China.
authors.forename: Zhilei
authors.initials: Z
authors.lastname: Zeng
authors.affiliation: Department of Neurology, Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450014, China.
authors.forename: Xiaopeng
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Neurology, PLA 148 Hospital, Zi bo, Shandong, 255300, China.
authors.forename: Yuzhen
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Neurology, PLA 148 Hospital, Zi bo, Shandong, 255300, China; Department of Neurology, Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450014, China,. Electronic address: wangylyl56@163.com.
authors.forename: Yunliang
authors.initials: Y
authors.lastname: Wang
mesh_terms: D017668:Age of Onset; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D000090762:Cytochrome P-450 CYP2J2; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D004843:Epistasis, Genetic; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D016015:Logistic Models; D008297:Male; D016017:Odds Ratio; D047495:PPAR gamma / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: C000717350:CYP2J2 protein, human; D047495:PPAR gamma; D003577:Cytochrome P-450 Enzyme System; D000090762:Cytochrome P-450 CYP2J2
keywords: CYP2J2; Haplotype; Interaction; PPAR -γ; SNP