title: Methimazole-Induced Agranulocytosis and Quick Recovery with G-CSF.
abstract: A 51-year old female, treated for hyperthyroidism with methimazole, developed agranulocytosis in the third month of therapy. After discontinuing the drug, a broad spectrum antibiotic regimen plus recombinant human granulocyte colony-stimulating factor (G-CSF) were started. Her granulocyte count returned to normal with the 4(°) dose of G-CSF. We think that in patients with methimazole-induced agranulocytosis, G-CSF may reduce the risk and severity of infection and in some cases should be accepted as a part of the standard therapy.
authors.affiliation: a Division of Hematology , University of Messina , Italy.
authors.forename: L
authors.initials: L
authors.lastname: Calabrò
authors.affiliation: a Division of Hematology , University of Messina , Italy.
authors.forename: A
authors.initials: A
authors.lastname: Alonci
authors.affiliation: a Division of Hematology , University of Messina , Italy.
authors.forename: G
authors.initials: G
authors.lastname: Bellomo
authors.affiliation: a Division of Hematology , University of Messina , Italy.
authors.forename: A
authors.initials: A
authors.lastname: D'Angelo
authors.affiliation: a Division of Hematology , University of Messina , Italy.
authors.forename: V
authors.initials: V
authors.lastname: Di Giacomo
authors.affiliation: a Division of Hematology , University of Messina , Italy.
authors.forename: C
authors.initials: C
authors.lastname: Musolino
keywords: G-CSF; Methimazole; agranulocytosis