title: The evaluation of renal hemodynamics changes in Familial Mediterranean fever with color Doppler sonography.
abstract: BACKGROUND
  Renal resistive index (RRI) scanned through renal Doppler is a practical marker employed in measuring blood flow in renal and intrarenal arteries and in noninvasive evaluation of renal vascular resistance. We aimed to investigate the renal hemodynamic variations in patients with Familial Mediterranean Fever (FMF).
  
  
  METHODS
  Seventy-nine FMF patients and 51 healthy subjects suitable for age and sex were included. Patients were divided into two groups according to their urinary albumin excretion. Fifty-two patients with 0-29 mg/day albuminuria were included in the normoalbuminuric group while 27 patients with 30-299 mg/day albuminuria were included in the microalbuminuric group.
  
  
  RESULTS
  RRI values were higher in patients with FMF compared to the healthy subjects (p < 0.0001). Additionally, RRI values were found to be higher in the microalbuminuric patients group compared to the normoalbuminuric patients group, and RRI values were also higher in normoalbuminuric patients group compared to the control group (p = 0.002, p < 0.0001). The ROC curve analysis suggested that the optimum RRI cutoff value for microalbuminuria in patients was 0.63, sensitivity of 66%, specificity of 60%, and p = 0.013.
  
  
  CONCLUSIONS
  RRI may be a marker that may be used in assessing resistance to renal blood flow, early renal damage, and progression of renal damage in FMF patients.
authors.affiliation: a Department of Radiology , Konya Numune Hospital , Konya , Turkey ;
authors.forename: Ferhat
authors.initials: F
authors.lastname: Sezer
authors.affiliation: b Department of Internal Medicine , Eskisehir Military Hospital , Eskisehir , Turkey ;
authors.forename: Ali Ugur
authors.initials: AU
authors.lastname: Uslu
authors.affiliation: c Department of Radiology, Faculty of Medicine , Cumhuriyet University , Sivas , Turkey ;
authors.forename: Hulusi
authors.initials: H
authors.lastname: Egilmez
authors.affiliation: d Gulhane School of Medicine , Department of Cardiology , Ankara , Turkey ;
authors.forename: Sevket
authors.initials: S
authors.lastname: Balta
authors.affiliation: e Department of Radiology , Amasya University SS Education and Research Hospital , Amasya , Turkey ;
authors.forename: Kenan
authors.initials: K
authors.lastname: Varol
authors.affiliation: f Department of Radiology , Mevlana University Faculty of Medicine , Konya , Turkey ;
authors.forename: Bilal
authors.initials: B
authors.lastname: Arik
authors.affiliation: c Department of Radiology, Faculty of Medicine , Cumhuriyet University , Sivas , Turkey ;
authors.forename: Emrah
authors.initials: E
authors.lastname: Seker
authors.affiliation: g Department of Cardiology, Faculty of Medicine , Cumhuriyet University , Sivas , Turkey ;
authors.forename: Hakan
authors.initials: H
authors.lastname: Gunes
authors.affiliation: h Department of Gastroenterology, Faculty of Medicine , Cumhuriyet University , Sivas , Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Yonem
mesh_terms: D000328:Adult; D000419:Albuminuria / Q000000981:diagnostic imaging*; D016022:Case-Control Studies; D010505:Familial Mediterranean Fever / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008297:Male; D012372:ROC Curve; D012079:Renal Circulation; D014421:Turkey; D018615:Ultrasonography, Doppler, Color; D014655:Vascular Resistance; D055815:Young Adult
keywords: Familial Mediterranean Fever; kidney injury; microalbuminuria; renal resistive index; urinary albumin excretion