title: Retrospective cohort investigation of perioperative upper respiratory events in children undergoing general anesthesia via a supraglottic airway: A comparison of sevoflurane and desflurane.
abstract: Desflurane is the most pungent of the currently used volatile anesthetics. We assessed whether the incidence of perioperative upper respiratory events in children undergoing general anesthesia via a supraglottic airway is higher with desflurane than with sevoflurane as maintenance anesthetic.We retrospectively reviewed and analyzed the electronic medical records of consecutive children 1 to 15 years of age who underwent general anesthesia via a supraglottic airway at Seoul National University Bundang Hospital between June 2013 and June 2015. The patients were assigned to the sevoflurane or desflurane group according to the anesthetic used. The characteristics of the patients were compared. The primary outcome variable was the incidence of upper respiratory events.The incidence of upper respiratory events in the 3439 evaluated patients was 0.43% (12/2777) in the sevoflurane group and 0.30% (2/662) in the desflurane group (P = 0.75; odds ratio = 0.69 [95% confidence interval = 0.16-3.13]). The difference between the 2 groups was not significant.Compared with sevoflurane, desflurane does not increase the risk of perioperative upper respiratory events in children receiving general anesthesia via a supraglottic airway.
authors.affiliation: Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam Department of Dental Anesthesiology, Seoul National University School of Dentistry, Seoul, Korea.
authors.forename: Hyun-Joung
authors.initials: HJ
authors.lastname: No
authors.forename: Bon-Wook
authors.initials: BW
authors.lastname: Koo
authors.forename: Ah-Young
authors.initials: AY
authors.lastname: Oh
authors.forename: Kwang-Suk
authors.initials: KS
authors.lastname: Seo
authors.forename: Hyo-Seok
authors.initials: HS
authors.lastname: Na
authors.forename: Jung-Hee
authors.initials: JH
authors.lastname: Ryu
authors.forename: Soo-Won
authors.initials: SW
authors.lastname: Lee
mesh_terms: D000293:Adolescent; D000768:Anesthesia, General / Q000009:adverse effects*; D018685:Anesthetics, Inhalation / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D000077335:Desflurane; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007530:Isoflurane / Q000009:adverse effects / Q000031:analogs & derivatives*; D008171:Lung Diseases / Q000139:chemically induced* / Q000453:epidemiology; D008297:Male; D008738:Methyl Ethers / Q000009:adverse effects*; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane; D000077335:Desflurane; D007530:Isoflurane