title: Salt and sugar: Bad company.
abstract: This report shed light to unrecognized mechanism for the hyperglycemia-induced sodium retention. The activation of PPAR?, elevation of serum adiponectin, and subsequent inhibition of SGLT2 may lead to natriuresis and glycosuria and it may be beneficial in hypertensive diabetic patients.
authors.affiliation: Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Wada
mesh_terms: D052242:Adiponectin / Q000378:metabolism; D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D003920:Diabetes Mellitus / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D006029:Glycosuria / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000150:complications / Q000378:metabolism*; D007674:Kidney Diseases / Q000209:etiology / Q000378:metabolism*; D051379:Mice; D009318:Natriuresis; D047492:Peroxisome Proliferator-Activated Receptors / Q000378:metabolism; D012964:Sodium / Q000378:metabolism*; D051297:Sodium-Glucose Transporter 2 / Q000378:metabolism
chemical_list: D052242:Adiponectin; D047492:Peroxisome Proliferator-Activated Receptors; C089180:SLC5A2 protein, human; D051297:Sodium-Glucose Transporter 2; D012964:Sodium; D005947:Glucose