title: [Risk factors of ISUP Modified Gleason score upgrading after radical prostatectomy].
abstract: OBJECTIVE
  To investigate the factors upgrading the International Society of Urological Pathology (ISUP) Gleason score using the specimens from preoperative prostatic biopsy and radical prostatectomy.
  
  
  METHODS
  A total of 164 patients diagnosed with prostate cancer by biopsy underwent radical prostatectomy. We retrospectively analyzed their age, prostate volume, preoperative PSA level, PSA density (PSAD) , the time interval between biopsy and surgery, the number of positive punctures, positive surgical margin, seminal vesicle invasion, lymphatic invasion, and Gleason scores from biopsy and prostatectomy. We also determined the predictors of Gleason score upgrading by logistic regression analysis.
  
  
  RESULTS
  Of the 164 cases analyzed, 95 (57.93% ) showed a consistency between the Gleason score of preoperative prostatic biopsy and that after radical prostatectomy, 55 (33.54% ) increased and 14 (8.52%) decreased after prostatectomy as compared with preoperative biopsy. The prostate volume (P < 0.01) and biopsy score (P < 0.05) were independent predictors of Gleason score upgrading. The risk of Gleason score upgrading was 27 times higher in the patients with the prostate volume ≤ 25 ml and 9 times higher in the 25-40 ml group than in the > 60 ml group (P < 0.05).
  
  
  CONCLUSIONS
  Low Gleason score of biopsy (≤ 6) and small prostate volume (≤ 40 ml) may be the predictors of Gleason score upgrading after radical prostatectomy.
authors.forename: Xiao-dong
authors.initials: XD
authors.lastname: Li
authors.forename: Gen-yi
authors.initials: GY
authors.lastname: Qu
authors.forename: Ning
authors.initials: N
authors.lastname: Xu
authors.forename: Xue-yi
authors.initials: XY
authors.lastname: Xue
authors.forename: Yong
authors.initials: Y
authors.lastname: Wei
authors.forename: Qing-shui
authors.initials: QS
authors.lastname: Zheng
authors.forename: Jun-feng
authors.initials: JF
authors.lastname: Li
authors.forename: Hai
authors.initials: H
authors.lastname: Cai
authors.forename: Yun-zhi
authors.initials: YZ
authors.lastname: Lin
mesh_terms: D001706:Biopsy; D006801:Humans; D008297:Male; D060787:Neoplasm Grading; D009929:Organ Size; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000145:classification / Q000601:surgery*; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D017430:Prostate-Specific Antigen