title: [Effectiveness of bupropion and counseling for smoking cessation].
abstract: OBJECTIVE
  To evaluate the effectiveness of bupropion for smoking cessation among Chinese smokers at a smoking cessation clinic.
  
  
  METHODS
  A prospective observational study was conducted in a hospital located in Beijing during 2008 and from 28 to 31 October 2014. A total of 287 smokers (265 men and 22 women) were assessed using data from structured questionnaires at baseline and were followed up at 1 and 6 months. Trained physician counselors provided free brief education and individual counseling sessions for all participants at the first visit. A total 131 participants were prescribed bupropion in addition to counseling. The counseling plus bupropion group was compared with the group who underwent counseling without bupropion. Outcomes were self-reported 7-day point prevalence abstinence rates at 1- and 6-month follow-up and continuous abstinence rates at 6-month follow-up. Smoking reduction rates at 1 and 6 months were also measured.
  
  
  RESULTS
  By intention-to-treat analysis, the 7-day point prevalence abstinence rate of the bupropion group at 1 and 6 months was higher than for the counseling-only group: at 1-month follow-up, 26.0% (34/131) vs. 15.4% (24/156), with OR (95% CI) 1.93(1.07-3.46); these rates at 6-month follow-up were 27.8% (35/131) vs. 15.4% (24/156), with OR (95% CI) 2.01(1.12-3.59). The 1-month continuous abstinence rate at 6 months was higher in the bupropion group: 26.0% (34/131) vs. 14.7% (23/156), with OR (95%CI) 2.03(1.12-3.66). Participants in the bupropion group also had a higher smoking reduction rate at 1 month than those in the counseling-only group: 55.0% (72/131) vs. 38.5% (60/156), with OR (95%CI) 1.95 (1.22-3.13).
  
  
  CONCLUSIONS
  Prescription of bupropion at this smoking cessation clinic was effective in doubling the quitting rates and smoking reduction rates among Chinese smokers.
authors.affiliation: Department of Traditional Chinese Medicine and Acupuncture, Nanlou Faculty of Clinical Medicine, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: B
authors.initials: B
authors.lastname: Jiang
authors.forename: Y
authors.initials: Y
authors.lastname: He
authors.forename: F
authors.initials: F
authors.lastname: Zuo
authors.forename: L
authors.initials: L
authors.lastname: Wu
authors.forename: Q H
authors.initials: QH
authors.lastname: Liu
authors.forename: L
authors.initials: L
authors.lastname: Zhang
authors.forename: C X
authors.initials: CX
authors.lastname: Zhou
authors.forename: J J
authors.initials: JJ
authors.lastname: Cheng
authors.forename: Z S
authors.initials: ZS
authors.lastname: Chan Sc
authors.forename: D Q
authors.initials: DQ
authors.lastname: Lam
mesh_terms: D018759:Adrenergic Uptake Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D000328:Adult; D000554:Ambulatory Care Facilities; D016642:Bupropion / Q000008:administration & dosage / Q000627:therapeutic use*; D002681:China / Q000453:epidemiology; D003376:Counseling; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012907:Smoking / Q000188:drug therapy / Q000208:ethnology / Q000628:therapy*; D016540:Smoking Cessation / Q000379:methods*; D011795:Surveys and Questionnaires; D014029:Tobacco Use Disorder / Q000188:drug therapy / Q000208:ethnology / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D018759:Adrenergic Uptake Inhibitors; D016642:Bupropion