title: Design of Nanoparticle-Based Carriers for Targeted Drug Delivery.
abstract: Nanoparticles have shown promise as both drug delivery vehicles and direct antitumor systems, but they must be properly designed in order to maximize efficacy. Computational modeling is often used both to design new nanoparticles and to better understand existing ones. Modeled processes include the release of drugs at the tumor site and the physical interaction between the nanoparticle and cancer cells. In this article, we provide an overview of three different targeted drug delivery methods (passive targeting, active targeting and physical targeting), compare methods of action, advantages, limitations, and the current stage of research. For the most commonly used nanoparticle carriers, fabrication methods are also reviewed. This is followed by a review of computational simulations and models on nanoparticle-based drug delivery.
authors.affiliation: Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.
authors.forename: Xiaojiao
authors.initials: X
authors.lastname: Yu
authors.affiliation: Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.
authors.forename: Ian
authors.initials: I
authors.lastname: Trase
authors.affiliation: Department of Chemical Physics, University of Science and Technology of China, Hefei, Anhui 230026, China.
authors.forename: Muqing
authors.initials: M
authors.lastname: Ren
authors.affiliation: Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.
authors.forename: Kayla
authors.initials: K
authors.lastname: Duval
authors.affiliation: Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.
authors.forename: Xing
authors.initials: X
authors.lastname: Guo
authors.affiliation: Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.
authors.forename: Zi
authors.initials: Z
authors.lastname: Chen
keywords: cancer; multiscale modeling; nanoparticle design; self-assembly of nanoparticles; targeted drug delivery