title: Uterine Cervix Metastasis of Myxopapillary Ependymoma Originated from the Spinal Cord.
abstract: BACKGROUND
  Myxopapillary ependymomas are well differentiated low-grade tumors which have been documented to local or distant metastasis. In the literature, this is a unique case of myxopapillary ependymoma with metastasis to the uterine cervix. Here, we present a rare case of extra neural metastasis of spinal ependymoma that developed over a long period.
  
  
  METHODS
  A 34-year-old woman was referred to our hospital for pelvic mass. A mass (110×100 mm) localized between the sacrococcygeal region and the uterus was detected by magnetic resonance imaging. In 2004, she had been operated upon for myxopapillary ependymoma seated in the sacrococcygeal region for the first time. She underwent tumor resection eight times due to the recurrence of spinal tumor in the same region in nine years. Under the diagnosis of uterine neoplasm, we carried out radical hysterectomy, omentectomy and pelvic lymphadenectomy as the surgical procedure. The pathological findings were reported as myxopapillary ependymoma. Immunohistochemically, the myxopapillary ependymal cells showed strong positivity for glial fibrillary acidic protein, whereas they were negative for low molecular weight cytokeratin. The Ki-67 labeling index was about 2-3%. The patient had an uneventful postoperative period. She has remained free of symptoms in the year since surgery.
  
  
  CONCLUSIONS
  Extra-spinal myxopapillary ependymoma is very rare, but it must be considered in the differential diagnosis of pelvic mass lesions.
authors.affiliation: Department of Obstetrics and Gynecology, İstanbul Medeniyet University Göztepe Training and Research Hospital, İstanbul, Turkey.
authors.forename: Kadir
authors.initials: K
authors.lastname: Güzin
authors.affiliation: Department of Obstetrics and Gynecology, İstanbul Medeniyet University Göztepe Training and Research Hospital, İstanbul, Turkey.
authors.forename: Halenur
authors.initials: H
authors.lastname: Bozdağ
authors.affiliation: Department of Pathology, İstanbul Medeniyet University Faculty of Medicine, İstanbul, Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Aydın
authors.affiliation: Departmenf of Obstetrics and Gynecology, Zeynep Kamil Training and Research Hospital, İstanbul, Turkey.
authors.forename: Sadık
authors.initials: S
authors.lastname: Şahin
authors.affiliation: Department of Pathology, İstanbul Medeniyet University Faculty of Medicine, İstanbul, Turkey.
authors.forename: Şeyma
authors.initials: Ş
authors.lastname: Özkanlı
keywords: Ependymoma; spinal cord tumor; uterine cervix