title: Small Heterodimer Partner (NR0B2) Coordinates Nutrient Signaling and the Circadian Clock in Mice.
abstract: Circadian rhythm regulates multiple metabolic processes and in turn is readily entrained by feeding-fasting cycles. However, the molecular mechanisms by which the peripheral clock senses nutrition availability remain largely unknown. Bile acids are under circadian control and also increase postprandially, serving as regulators of the fed state in the liver. Here, we show that nuclear receptor Small Heterodimer Partner (SHP), a regulator of bile acid metabolism, impacts the endogenous peripheral clock by directly regulating Bmal1. Bmal1-dependent gene expression is altered in Shp knockout mice, and liver clock adaptation is delayed in Shp knockout mice upon restricted feeding. These results identify SHP as a potential mediator connecting nutrient signaling with the circadian clock.
authors.affiliation: Department of Molecular and Cellular Biology (N.W., K.H.K., Y.Z., J.M.L., N.M.K., J.L.M., S.C., L.F., D.D.M.) and Program in Developmental Biology (S.C.), Baylor College of Medicine, Houston, Texas 77030; and Department of Biochemistry and Cell Biology (J.M.L.), School of Medicine, Kyungpook National University, Jung-gu, Daegu 41944, Republic of Korea.
authors.forename: Nan
authors.initials: N
authors.lastname: Wu
authors.affiliation: Department of Molecular and Cellular Biology (N.W., K.H.K., Y.Z., J.M.L., N.M.K., J.L.M., S.C., L.F., D.D.M.) and Program in Developmental Biology (S.C.), Baylor College of Medicine, Houston, Texas 77030; and Department of Biochemistry and Cell Biology (J.M.L.), School of Medicine, Kyungpook National University, Jung-gu, Daegu 41944, Republic of Korea.
authors.forename: Kang Ho
authors.initials: KH
authors.lastname: Kim
authors.affiliation: Department of Molecular and Cellular Biology (N.W., K.H.K., Y.Z., J.M.L., N.M.K., J.L.M., S.C., L.F., D.D.M.) and Program in Developmental Biology (S.C.), Baylor College of Medicine, Houston, Texas 77030; and Department of Biochemistry and Cell Biology (J.M.L.), School of Medicine, Kyungpook National University, Jung-gu, Daegu 41944, Republic of Korea.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Molecular and Cellular Biology (N.W., K.H.K., Y.Z., J.M.L., N.M.K., J.L.M., S.C., L.F., D.D.M.) and Program in Developmental Biology (S.C.), Baylor College of Medicine, Houston, Texas 77030; and Department of Biochemistry and Cell Biology (J.M.L.), School of Medicine, Kyungpook National University, Jung-gu, Daegu 41944, Republic of Korea.
authors.forename: Jae Man
authors.initials: JM
authors.lastname: Lee
authors.affiliation: Department of Molecular and Cellular Biology (N.W., K.H.K., Y.Z., J.M.L., N.M.K., J.L.M., S.C., L.F., D.D.M.) and Program in Developmental Biology (S.C.), Baylor College of Medicine, Houston, Texas 77030; and Department of Biochemistry and Cell Biology (J.M.L.), School of Medicine, Kyungpook National University, Jung-gu, Daegu 41944, Republic of Korea.
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Kettner
authors.affiliation: Department of Molecular and Cellular Biology (N.W., K.H.K., Y.Z., J.M.L., N.M.K., J.L.M., S.C., L.F., D.D.M.) and Program in Developmental Biology (S.C.), Baylor College of Medicine, Houston, Texas 77030; and Department of Biochemistry and Cell Biology (J.M.L.), School of Medicine, Kyungpook National University, Jung-gu, Daegu 41944, Republic of Korea.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Mamrosh
authors.affiliation: Department of Molecular and Cellular Biology (N.W., K.H.K., Y.Z., J.M.L., N.M.K., J.L.M., S.C., L.F., D.D.M.) and Program in Developmental Biology (S.C.), Baylor College of Medicine, Houston, Texas 77030; and Department of Biochemistry and Cell Biology (J.M.L.), School of Medicine, Kyungpook National University, Jung-gu, Daegu 41944, Republic of Korea.
authors.forename: Sungwoo
authors.initials: S
authors.lastname: Choi
authors.affiliation: Department of Molecular and Cellular Biology (N.W., K.H.K., Y.Z., J.M.L., N.M.K., J.L.M., S.C., L.F., D.D.M.) and Program in Developmental Biology (S.C.), Baylor College of Medicine, Houston, Texas 77030; and Department of Biochemistry and Cell Biology (J.M.L.), School of Medicine, Kyungpook National University, Jung-gu, Daegu 41944, Republic of Korea.
authors.forename: Loning
authors.initials: L
authors.lastname: Fu
authors.affiliation: Department of Molecular and Cellular Biology (N.W., K.H.K., Y.Z., J.M.L., N.M.K., J.L.M., S.C., L.F., D.D.M.) and Program in Developmental Biology (S.C.), Baylor College of Medicine, Houston, Texas 77030; and Department of Biochemistry and Cell Biology (J.M.L.), School of Medicine, Kyungpook National University, Jung-gu, Daegu 41944, Republic of Korea.
authors.forename: David D
authors.initials: DD
authors.lastname: Moore
mesh_terms: D056930:ARNTL Transcription Factors / Q000235:genetics / Q000378:metabolism; D000818:Animals; D002478:Cells, Cultured; D002940:Circadian Rhythm / Q000235:genetics / Q000502:physiology; D015151:Immunoblotting; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology
chemical_list: D056930:ARNTL Transcription Factors; C538961:Bmal1 protein, mouse; C431936:Nr5a2 protein, mouse; D018160:Receptors, Cytoplasmic and Nuclear; C099713:nuclear receptor subfamily 0, group B, member 2