title: Extending Time Profile of Morphine-Induced Analgesia Using a Chitosan-Based Molecular Imprinted Polymer Nanogel.
abstract: Chitosan-based molecular imprinted polymer (CS-MIP) nanogel is prepared in the presence of morphine template, fully characterized and used as a new vehicle to extend duration of morphine analgesic effect in Naval Medical Research Institute mice. The CS-MIP nanogel with ≈25 nm size range exhibits 98% loading efficiency, and in vitro release studies show an initial burst followed by an extended slow release of morphine. In order to study the feasibility of CS-MIP nanogel as morphine carrier, 20 mice are divided into two groups randomly and received subcutaneous injection of morphine-loaded CS-MIP and morphine (10 mg kg-1) dissolved in physiologic saline. Those received injection of morphine-loaded CS-MIP show slower and long lasting release of morphine with 193 min effective time of 50% (ET50) analgesia compared to 120 min ET50 in mice received morphine dissolved in physiologic saline. These results suggest that CS-MIP nanogel can be a possible strategy as morphine carrier for controlled release and extension of its analgesic efficacy.
authors.affiliation: Polymer Chemistry Research Laboratory, Faculty of Chemistry, University of Mazandaran, Babolsar, 47416-95447, Iran.
authors.forename: Marjan
authors.initials: M
authors.lastname: Hassanzadeh
authors.affiliation: Polymer Chemistry Research Laboratory, Faculty of Chemistry, University of Mazandaran, Babolsar, 47416-95447, Iran. ghaemy@umz.ac.ir.
authors.forename: Mousa
authors.initials: M
authors.lastname: Ghaemy
authors.affiliation: Department of Biological Science, Faculty of Science, University of Kurdistan, Sanandaj, 66177-15177, Iran.
authors.forename: Shamseddin
authors.initials: S
authors.lastname: Ahmadi
mesh_terms: D000698:Analgesia / Q000379:methods*; D000818:Animals; D048271:Chitosan / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D005782:Gels; D008297:Male; D051379:Mice; D009020:Morphine / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D003692:Delayed-Action Preparations; D005782:Gels; D009020:Morphine; D048271:Chitosan
keywords: chitosan; controlled release; mice; molecular imprinted polymer; morphine analgesia