title: New Insights into Dialysis Vascular Access: Molecular Targets in Arteriovenous Fistula and Arteriovenous Graft Failure and Their Potential to Improve Vascular Access Outcomes.
abstract: Vascular access dysfunction remains a major cause of morbidity and mortality in hemodialysis patients. At present there are few effective therapies for this clinical problem. The poor understanding of the pathobiology that leads to arteriovenous fistula (AVF) and graft (AVG) dysfunction remains a critical barrier to development of novel and effective therapies. However, in recent years we have made substantial progress in our understanding of the mechanisms of vascular access dysfunction. This article presents recent advances and new insights into the pathobiology of AVF and AVG dysfunction and highlights potential therapeutic targets to improve vascular access outcomes.
authors.affiliation: Department of Medicine and Division of Nephrology, University of Alabama at Birmingham, Birmingham, Alabama.|Veterans Affairs Medical Center, Birmingham, Alabama; and.
authors.forename: Timmy
authors.initials: T
authors.lastname: Lee
authors.affiliation: Vascular and Interventional Radiology Translational Laboratory, Department of Radiology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Misra
mesh_terms: D000818:Animals; D001166:Arteriovenous Shunt, Surgical / Q000009:adverse effects*; D001808:Blood Vessels / Q000473:pathology*; D019295:Computational Biology; D003251:Constriction, Pathologic / Q000209:etiology; D004730:Endothelium, Vascular / Q000503:physiopathology; D005355:Fibrosis; D006801:Humans; D006965:Hyperplasia / Q000150:complications; D007249:Inflammation / Q000188:drug therapy; D007676:Kidney Failure, Chronic / Q000628:therapy; D058990:Molecular Targeted Therapy; D058426:Neointima / Q000473:pathology*; D018384:Oxidative Stress / Q000187:drug effects; D006435:Renal Dialysis; D058017:Vascular Grafting / Q000009:adverse effects*; D014654:Vascular Patency; D066253:Vascular Remodeling
keywords: Arteriovenous access; Arteriovenous fistula; Arteriovenous graft