title: DAS28 score vs. ultrasound examination for assessment of rheumatoid arthritis disease activity: comparison and discussion of pros and cons.
abstract: Rheumatoid arthritis (RA) is a chronic systemic connective tissue disease which is characterized by symetrical multiple joints involvement and extra-articular symptoms. Current EULAR diagnostic criteria for RA include disease activity parameters, such as erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), which are used to calculate disease activity scores, including DAS and DAS28. Recently attempts have been made to assess disease activity using imaging diagnostic modalities, such as magnetic resonance imaging (MRI) and ultrasonography (US). Due to significant progress in therapy effectiveness and early RA diagnosis possibility, imaging modalities become increasingly meaningful and many clinical trials confirm their usefulness. However, there are no consistent criteria for objective assessment of therapy effectiveness based on US. Moreover, it is not US availability that limits its common use, but rather significant variability between operators. This is why US remains only an additional tool to assess therapy efficacy with regard to DAS/DAS28 index.
authors.affiliation: Clinic of Rheumatology and Connective Tissue Diseases, University Hospital Nr 2 Dr. Jan Biziel, Bydgoszcz, Poland.
authors.forename: Tacjana Anna
authors.initials: TA
authors.lastname: Barczyńska
authors.affiliation: NZOZ Nasz Lekarz, Torun, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Dura
authors.affiliation: Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.
authors.forename: Einat
authors.initials: E
authors.lastname: Blumfield
authors.affiliation: Clinic of Rheumatology and Connective Tissue Diseases, University Hospital Nr 2 Dr. Jan Biziel, Bydgoszcz, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Węgierska
authors.affiliation: Independent Section of Scientific Research Coordination and Didactic Activity, University Hospital Nr 2 Dr. Jan Biziel, Bydgoszcz, Poland.
authors.forename: Pawel
authors.initials: P
authors.lastname: Żuchowski
authors.affiliation: Clinic of Rheumatology and Connective Tissue Diseases, University Hospital Nr 2 Dr. Jan Biziel, Bydgoszcz, Poland.
authors.forename: Arnika
authors.initials: A
authors.lastname: Wilińska-Jankowska
authors.affiliation: Clinic of Rheumatology and Connective Tissue Diseases, University Hospital Nr 2 Dr. Jan Biziel, Bydgoszcz, Poland.
authors.forename: Sławomir
authors.initials: S
authors.lastname: Jeka
keywords: DAS28; rheumatoid arthritis; ultrasonography