title: Body weight changes in children with idiopathic nephrotic syndrome.
abstract: BACKGROUND
  Aim of the study was to evaluate factors affecting body mass change in children with idiopathic nephrotic syndrome (INS) during 6-months treatment of initial disease bout with glucocorticoids (GC).
  
  
  METHODS
  We studied 31 children with INS (22♂, 9♀, 3.6±1.8 years) treated during 6 months with GC due to initial INS bout and 31 control healthy children (18♂, 13♀, 4.0±1.8 years). Following factors were evaluated: body mass, body mass index (BMI), BMI Z-score, gender, age, gestational age at birth, birth weight, GC dose, parental age and BMI, time spent for TV/computer, physical activity, place of residence.
  
  
  RESULTS
  Mean initial BMI Z-score was 0.35±1.1 in children with INS and -0.11±1.5 in the control group, after 6 months 0.8±1.2 (P=0.049) and 0.07±1.5 (P=0.629), respectively. Δ0-6 BMI Z-score correlated with initial BMI Z-score (r=-0.45, P=0.001), maternal age (r=0.38, P=0.04), and paternal BMI (r=0.51, P=0.0037).
  
  
  CONCLUSIONS
  1. Initial 6-month GC therapy may result in body mass increase in children with INS. 2. Risk factors for body mass increase in children with INS during the first 6 months of therapy include low initial BMI, older maternal age and paternal obesity.
authors.affiliation: Department of Pediatrics and Nephrology, Medical University of Warsaw, Poland.
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Kuźma-Mroczkowska
authors.affiliation: Department of Pediatrics and Nephrology, Medical University of Warsaw, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Pańczyk-Tomaszewska
authors.affiliation: Department of Pediatrics and Nephrology, Medical University of Warsaw, Poland, e-mail: pskrzyp@gmail.com.
authors.forename: Piotr
authors.initials: P
authors.lastname: Skrzypczyk
authors.affiliation: Department of Pediatrics and Nephrology, Medical University of Warsaw, Poland.
authors.forename: Iwona
authors.initials: I
authors.lastname: Artemiuk
authors.affiliation: Department of Pediatrics and Nephrology, Medical University of Warsaw, Poland.
authors.forename: Maria
authors.initials: M
authors.lastname: Roszkowska-Blaim
mesh_terms: D000367:Age Factors; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008297:Male; D009404:Nephrotic Syndrome / Q000150:complications* / Q000188:drug therapy* / Q000503:physiopathology; D009765:Obesity / Q000209:etiology*; D011241:Prednisone / Q000627:therapeutic use*; D012307:Risk Factors; D012737:Sex Factors; D015430:Weight Gain / Q000187:drug effects*
chemical_list: D005938:Glucocorticoids; D011241:Prednisone
keywords: children; glucocorticoids; nephrotic syndrome; obesity; risk factors