title: Association of blood glucose level and hypertension in Elderly Chinese Subjects: a community based study.
abstract: BACKGROUND
  There is a scarcity of epidemiological researches examining the relationship between blood pressure (BP) and glucose level among older adults. The objective of the current study was to investigate the association of high BP and glucose level in elderly Chinese.
  
  
  METHODS
  A cross-sectional study of a population of 2092 Chinese individuals aged over 65 years was conducted. Multiple logistic analysis was used to explore the association between hypertension and hyperglycemia. Independent risk factors for systolic and diastolic BP were analyzed using stepwise linear regression.
  
  
  RESULTS
  Subjects in impaired fasting glucose group (IFG) (n = 144) and diabetes (n = 346), as compared with normal fasting glucose (NFG) (n = 1277), had a significant higher risk for hypertension, with odds ratios (ORs) of 1.81 (95 % CI, 1.39-2.35) (P = 0.000) and 1.40 (95 % CI, 1.09-1.80) (P = 0.009), respectively. Higher fasting plasma glucose (FPG) levels in the normal range were still significantly associated with a higher prevalence of hypertension in both genders, with ORs of 1.24 (95 % CI, 0.85-1.80), R (2) = 0.114, P = 0.023 in men and 1.61 (95 % CI, 1.12-2.30), R (2) = 0.082, P = 0.010 in women, respectively, when compared with lower FPG. Linear regression analysis revealed FPG was an independent factor of systolic and diastolic BP.
  
  
  CONCLUSIONS
  Our findings suggest that hyperglycemia as well as higher FPG within the normal range is associated with a higher prevalence of hypertension independent of other cardiovascular risk factors in elderly Chinese. Further studies are needed to explore the relationship between hyperglycemia and hypertension in a longitudinal setting.
authors.affiliation: Department of Endocrinology, Shanghai East Hospital, Tongji University School of Medicine, 150 Jimo Road, Shanghai, 200120, China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Yan
authors.affiliation: Department of Endocrinology, Shanghai East Hospital, Tongji University School of Medicine, 150 Jimo Road, Shanghai, 200120, China.|Puxing Community Health-Care Center, Pudong New District, 250 GuiChang Road, Shanghai, 200136, China.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Sun
authors.affiliation: Department of Endocrinology, Shanghai East Hospital, Tongji University School of Medicine, 150 Jimo Road, Shanghai, 200120, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Li
authors.affiliation: Puxing Community Health-Care Center, Pudong New District, 250 GuiChang Road, Shanghai, 200136, China.
authors.forename: Guoliang
authors.initials: G
authors.lastname: Chen
authors.affiliation: Puxing Community Health-Care Center, Pudong New District, 250 GuiChang Road, Shanghai, 200136, China.
authors.forename: Qinghu
authors.initials: Q
authors.lastname: Zheng
authors.affiliation: Puxing Community Health-Care Center, Pudong New District, 250 GuiChang Road, Shanghai, 200136, China.
authors.forename: Lun
authors.initials: L
authors.lastname: Li
authors.affiliation: Puxing Community Health-Care Center, Pudong New District, 250 GuiChang Road, Shanghai, 200136, China.
authors.forename: Chenhong
authors.initials: C
authors.lastname: Gu
authors.affiliation: Department of Endocrinology, Shanghai East Hospital, Tongji University School of Medicine, 150 Jimo Road, Shanghai, 200120, China. fengbo@medmail.com.cn.
authors.forename: Bo
authors.initials: B
authors.lastname: Feng
mesh_terms: D000368:Aged; D001786:Blood Glucose; D001794:Blood Pressure; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000150:complications* / Q000453:epidemiology / Q000378:metabolism; D006973:Hypertension / Q000150:complications* / Q000453:epidemiology / Q000378:metabolism; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D015995:Prevalence; D012307:Risk Factors
chemical_list: D001786:Blood Glucose
keywords: Cross-sectional study; Diabetes; Fasting plasma glucose; Hypertension