title: Opening a Chromatin Gate to Metastasis.
abstract: What changes need to occur in a primary tumor to make it metastatic? Denny et al. address this question for small cell lung cancer (SCLC), finding that changes in genomic accessibility mediated by a single transcription factor, NFIB, comprise at least one mechanism influencing metastasis.
authors.affiliation: Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: john.minna@utsouthwestern.edu.
authors.forename: John D
authors.initials: JD
authors.lastname: Minna
authors.affiliation: Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: jane.johnson@utsouthwestern.edu.
authors.forename: Jane E
authors.initials: JE
authors.lastname: Johnson
mesh_terms: D045744:Cell Line, Tumor; D002843:Chromatin; D006801:Humans; D008175:Lung Neoplasms; D009362:Neoplasm Metastasis; D055752:Small Cell Lung Carcinoma / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics
chemical_list: D002843:Chromatin; D014157:Transcription Factors