title: Relationship of serum GDF11 levels with bone mineral density and bone turnover markers in postmenopausal Chinese women.
abstract: Growth differentiation factor 11 (GDF11) is an important circulating factor that regulates aging. However, the role of GDF11 in bone metabolism remains unclear. The present study was undertaken to investigate the relationship between serum GDF11 level, bone mass, and bone turnover markers in postmenopausal Chinese women. Serum GDF11 level, bone turnover biochemical markers, and bone mineral density (BMD) were determined in 169 postmenopausal Chinese women (47-78 years old). GDF11 serum levels increased with aging. There were negative correlations between GDF11 and BMD at the various skeletal sites. After adjusting for age and body mass index (BMI), the correlations remained statistically significant. In the multiple linear stepwise regression analysis, age or years since menopause, BMI, GDF11, and estradiol were independent predictors of BMD. A significant negative correlation between GDF11 and bone alkaline phosphatase (BAP) was identified and remained significant after adjusting for age and BMI. No significant correlation was noted between cross-linked N-telopeptides of type I collagen (NTX) and GDF11. In conclusion, GDF11 is an independent negative predictor of BMD and correlates with a biomarker of bone formation, BAP, in postmenopausal Chinese women. GDF11 potentially exerts a negative effect on bone mass by regulating bone formation.
authors.affiliation: Institute of Endocrinology and Metabolism, The Second Xiangya Hospital of Central South University , Changsha, China.
authors.forename: Yusi
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Hunan University of Medicine , Huaihua, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Guo
authors.affiliation: Hunan University of Medicine , Huaihua, China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology, The Xiangya Hospital of Central South University , Changsha, China.
authors.forename: Shumin
authors.initials: S
authors.lastname: Song
authors.affiliation: Hunan University of Medicine , Huaihua, China.
authors.forename: Tonggui
authors.initials: T
authors.lastname: Quan
authors.affiliation: Hunan University of Medicine , Huaihua, China.
authors.forename: Tiepeng
authors.initials: T
authors.lastname: Zhao
authors.affiliation: Hunan University of Medicine , Huaihua, China.
authors.forename: Hongliang
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Endocrinology, The Xiangya Hospital of Central South University , Changsha, China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Guo
authors.affiliation: Department of Endocrinology, The Xiangya Hospital of Central South University , Changsha, China.
authors.forename: Tiejian
authors.initials: T
authors.lastname: Jiang
authors.affiliation: Hunan University of Medicine , Huaihua, China.
authors.forename: Guangwei
authors.initials: G
authors.lastname: Wang