title: Nephroprotective action of Peucedanum grande against cadmium chloride induced renal toxicity in Wistar rats.
abstract: Cadmium is a known industrial pollutant which accumulates in the kidney and its exposure leads to the production of reactive oxygen species (ROS). The present study was carried out to evaluate the protective effects of Peucedanum grande against CdCl2 induced renal toxicity in Wistar rats. Wistar rats were subjected to oral pre-treatment of P. grande (60 and 120 mg/kg b.wt) against the renal toxicity induced by administration of CdCl2 (3mg/kg b.wt). Efficacy of P. grande against the renal toxicity was evaluated in terms of biochemical estimation of antioxidant enzyme activities and histopathological changes. P. grande pretreatment prevented deteriorative effects induced by CdCl2 through a protective mechanism that involved reduction of increased oxidative stress as well as by restoration of histopathological changes against CdCl2 administration.
authors.affiliation: Department of Ilmul-Advia, Faculty of Medicine (U), Jamia Hamdard, New Delhi-62.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Aslam
authors.affiliation: Section of Molecular Carcinogenesis & Chemoprevention, Department of Medical Elementology & Toxicology, Jamia Hamdard, New Delhi-62.
authors.forename: Shiekh Tanveer
authors.initials: ST
authors.lastname: Ahmad
authors.affiliation: Ex-Head, Chemistry Division, Forest Research Institute, Dehradun, Uttranchal.
authors.forename: Rameshver
authors.initials: R
authors.lastname: Dayal
authors.affiliation: Department of Chemistry, Faculty of Science, Jamia Hamdard, New Delhi-62.
authors.forename: Kalim
authors.initials: K
authors.lastname: Javid
authors.affiliation: Clinical Toxicology Lab., Department of Medical Elementology & Toxicology, Jamia Hamdard, New Delhi-62.
authors.forename: Sadiq
authors.initials: S
authors.lastname: Umar
authors.affiliation: Department of Biochemistry, University of Kashmir, Hazratbal, Srinagar, J&K-190006.
authors.forename: Asia
authors.initials: A
authors.lastname: Asiaf
authors.affiliation: Section of Molecular Carcinogenesis & Chemoprevention, Department of Medical Elementology & Toxicology, Jamia Hamdard, New Delhi-62.
authors.forename: Sana
authors.initials: S
authors.lastname: Nafees
authors.affiliation: Department of Ilmul-Advia, Faculty of Medicine (U), Jamia Hamdard, New Delhi-62.
authors.forename: Jalal Uddin
authors.initials: JU
authors.lastname: Bhat
authors.affiliation: Section of Molecular Carcinogenesis & Chemoprevention, Department of Medical Elementology & Toxicology, Jamia Hamdard, New Delhi-62.
authors.forename: Arjumand
authors.initials: A
authors.lastname: Wani
authors.affiliation: Faculty of Pharmacy, Jamia Hamdard, New Delhi-62.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Samim
authors.affiliation: Department of Pharmacology, AIIMS, Ansari Nagar, New Delhi-29.
authors.forename: Surender
authors.initials: S
authors.lastname: Singh
keywords: Peucedanum grande; ROS; cadmium chloride; nephrotoxicity