title: Women, Hypertension, and the Systolic Blood Pressure Intervention Trial.
abstract: Hypertension accounts for approximately 1 in 5 deaths in American women and is the major contributor to many comorbid conditions. Although blood pressure lowering reduces cardiovascular disease outcomes, considerable uncertainty remains on best management in women. Specifically, female blood pressure treatment goals have not been established, particularly among older and African American and Hispanic women, for whom hypertension prevalence, related adverse outcomes, and poor control rates are high. The Systolic Blood Pressure Intervention Trial (SPRINT) planned to clarify optimal blood pressure management in both sexes. Although confirming that a lower blood pressure goal is generally better, because female enrollment and event rates were low and follow-up shortened, outcomes differences in women were not statistically significant. Thus optimal blood pressure goals for women have not been established with the highest evidence. This review addresses SPRINT's significance and key remaining knowledge gaps in optimal blood pressure management to improve women's health.
authors.affiliation: Department of Cardiology, Emory University School of Medicine Atlanta, Ga.
authors.forename: Nanette K
authors.initials: NK
authors.lastname: Wenger
authors.affiliation: Tulane University Heart and Vascular Institute, Tulane University School of Medicine, New Orleans, La.
authors.forename: Keith C
authors.initials: KC
authors.lastname: Ferdinand
authors.affiliation: Department of Cardiology, Cedars-Sinai Heart Institute, Los Angeles, Calif.
authors.forename: C Noel
authors.initials: CN
authors.lastname: Bairey Merz
authors.affiliation: St. Vincent Heart Center, Indianapolis, Ind.
authors.forename: Mary Norine
authors.initials: MN
authors.lastname: Walsh
authors.affiliation: Division of Cardiology, University of Arizona-Phoenix.
authors.forename: Martha
authors.initials: M
authors.lastname: Gulati
authors.affiliation: Division of Cardiovascular Medicine, University of Florida, Gainesville. Electronic address: carl.pepine@medicine.ufl.edu.
authors.forename: Carl J
authors.initials: CJ
authors.lastname: Pepine
mesh_terms: D001741:Black or African American; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D010347:Patient Care Planning; D018579:Patient Selection; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome; D044465:White People
chemical_list: D000959:Antihypertensive Agents
keywords: Adverse outcomes; Blood pressure; Cardiovascular disease; Hypertension; Intervention; Level of evidence; Sex-specific pathophysiology; Systolic Blood Pressure Intervention Trial; Treatment goals