title: A systematic evaluation for the potential translation of CD166-related expression as a cancer biomarker.
abstract: Many basic studies have provided some evidences for the correlations of CD166 to cancer. However, along with the growing studies on the clinical values of CD166 in cancer areas, some controversial and inconclusive results were obtained.
  
  
  
  An appropriate query and collection of the published articles was conducted through search in PubMed and EMBASE database. A subsequent systematical and quantitative summary of CD166 related expression and cancer was conducted with meta-analysis to clarify its clinical significance for potential translation as cancer biomarkers. Expert commentary: The overall results suggested total CD166 correlated to cancer risk, membrane CD166 correlated to nodal metastasis and cytoplasmic CD166 correlated to TNM stage, and disease-free survival. The membrane CD166, cytoplasmic CD166 and soluble CD166 showed great potential to be used as a panel of markers for predicting cancer overall survival. We might conclude that CD166 functions as a risk factor for cancers, and the alterations of its different functional isoforms were observed to correlate with specific or interplayed clinical outcomes.
authors.affiliation: a Department of Oral and Maxillofacial-Head & Neck Oncology and Faculty of Oral and Maxillofacial Surgery, Ninth People's Hospital , Shanghai Jiao Tong University School of Medicine , Shanghai , China.|b Shanghai Research Institute of Stomatology and Shanghai Key Laboratory of Stomatology , Shanghai , China.
authors.forename: Meng
authors.initials: M
authors.lastname: Xiao
authors.affiliation: a Department of Oral and Maxillofacial-Head & Neck Oncology and Faculty of Oral and Maxillofacial Surgery, Ninth People's Hospital , Shanghai Jiao Tong University School of Medicine , Shanghai , China.|b Shanghai Research Institute of Stomatology and Shanghai Key Laboratory of Stomatology , Shanghai , China.
authors.forename: Xu
authors.initials: X
authors.lastname: Wang
authors.affiliation: a Department of Oral and Maxillofacial-Head & Neck Oncology and Faculty of Oral and Maxillofacial Surgery, Ninth People's Hospital , Shanghai Jiao Tong University School of Medicine , Shanghai , China.|b Shanghai Research Institute of Stomatology and Shanghai Key Laboratory of Stomatology , Shanghai , China.
authors.forename: Ming
authors.initials: M
authors.lastname: Yan
authors.affiliation: a Department of Oral and Maxillofacial-Head & Neck Oncology and Faculty of Oral and Maxillofacial Surgery, Ninth People's Hospital , Shanghai Jiao Tong University School of Medicine , Shanghai , China.|b Shanghai Research Institute of Stomatology and Shanghai Key Laboratory of Stomatology , Shanghai , China.
authors.forename: Wantao
authors.initials: W
authors.lastname: Chen
mesh_terms: D015703:Antigens, CD / Q000096:biosynthesis*; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D015816:Cell Adhesion Molecules, Neuronal / Q000096:biosynthesis*; D018572:Disease-Free Survival; D005326:Fetal Proteins / Q000096:biosynthesis*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D009369:Neoplasms / Q000378:metabolism* / Q000401:mortality; D012307:Risk Factors; D015996:Survival Rate; D020410:Activated-Leukocyte Cell Adhesion Molecule
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; D015816:Cell Adhesion Molecules, Neuronal; D005326:Fetal Proteins; D009363:Neoplasm Proteins; C105613:ALCAM protein, human; D020410:Activated-Leukocyte Cell Adhesion Molecule
keywords: Activated leukocyte cell adhesion molecule; CD166; cancer biomarker; meta-analysis; metastasis; prognosis