title: Chronic pregabalin treatment decreases excitability of dentate gyrus and accelerates maturation of adult-born granule cells.
abstract: Pregabalin (PGB) is extensively prescribed to treat neurological and neuropsychiatrical conditions such as neuropathic pain, anxiety disorders, and epilepsy. Although PGB is known to bind selectively to the α2δ subunit of voltage-gated calcium channels, there is little understanding about how it exerts its therapeutic effects. In this article, we analyzed the effects of an in vivo chronic treatment with PGB over the physiology of dentate gyrus granule cells (DGGCs) using ex vivo electrophysiological and morphological analysis in adult mice. We found that PGB decreases neuronal excitability of DGGCs. In addition, PGB accelerates maturation of adult-born DGGCs, an effect that would modify dentate gyrus plasticity. Together, these findings suggest that PGB reduces activity in the dentate gyrus and modulates overall network plasticity, which might contribute to its therapeutic effects. Cover Image for this issue: doi: 10.1111/jnc.13783.
authors.affiliation: Instituto de Fisiología Biología Molecular y Neurociencias (IFIBYNE, UBA-CONICET), Buenos Aires, Argentina.
authors.forename: Augusto Abel
authors.initials: AA
authors.lastname: Lempel
authors.affiliation: Instituto de Fisiología Biología Molecular y Neurociencias (IFIBYNE, UBA-CONICET), Buenos Aires, Argentina.
authors.forename: Lucia
authors.initials: L
authors.lastname: Coll
authors.affiliation: Fundación Instituto Leloir, Instituto de Investigaciones Bioquímicas de Buenos Aires (IIBBA - CONICET), Buenos Aires, Argentina.
authors.forename: Alejandro F
authors.initials: AF
authors.lastname: Schinder
authors.affiliation: Instituto de Fisiología Biología Molecular y Neurociencias (IFIBYNE, UBA-CONICET), Buenos Aires, Argentina.
authors.forename: Osvaldo Daniel
authors.initials: OD
authors.lastname: Uchitel
authors.affiliation: Instituto de Fisiología Biología Molecular y Neurociencias (IFIBYNE, UBA-CONICET), Buenos Aires, Argentina.|Instituto de Fisiología y Biofísica "Houssay" (IFIBIO "Houssay", UBA-CONICET), Buenos Aires, Argentina.
authors.forename: Joaquin
authors.initials: J
authors.lastname: Piriz
mesh_terms: D000375:Aging; D000818:Animals; D015220:Calcium Channels / Q000187:drug effects* / Q000378:metabolism; D003594:Cytoplasmic Granules / Q000187:drug effects / Q000378:metabolism; D018891:Dentate Gyrus / Q000187:drug effects* / Q000502:physiology; D004827:Epilepsy / Q000188:drug therapy; D008810:Mice, Inbred C57BL; D009437:Neuralgia / Q000188:drug therapy*; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D000069583:Pregabalin / Q000008:administration & dosage / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
chemical_list: D015220:Calcium Channels; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid
keywords: Gabapentin; Pregabalin; dentate gyrus; neurogenesis