title: Electrical characterization of DNA supported on nitrocellulose membranes.
abstract: Integrated DNA-based nanoscale electronic devices will enable the continued realization of Moore's Law at the level of functional devices and systems. In this work, the electrical characterization of single and complementary base paired DNA has been directly measured and investigated via the use of nitrocellulose membranes. A radio frequency DAKS-3.5 was used to measure the reflection coefficients of different DNA solutions dotted onto nitrocellulose membranes. Each DNA solution was exposed to a radio frequency signal with a power of 10 dBm and with a sweep from 200 MHz up to 13.6 GHz. The conducted measurements show some distinctions between the homomeric and complementary bases due to their different electrical polarization. As revealed from the measurements conducted, with the addition of DNA oligonucleotides, the measured capacitance increased when compared with buffer medium alone. The DNA molecules could be modeled as dielectric material that can hold electrical charges. Furthermore, the complementary paired DNA molecule-based inks solutions had a higher capacitance value compared with single DNA molecules (A, C, G and T) solutions.
authors.affiliation: Department of Electrical Engineering, College of Engineering, United Arab Emirates University, Al Ain, UAE.|Zayed Bin Sultan Center for Health Sciences Division, United Arab Emirates University, Al Ain, UAE.
authors.forename: Mahmoud Al
authors.initials: MA
authors.lastname: Ahmad
authors.affiliation: Department of Electrical Engineering, College of Engineering, United Arab Emirates University, Al Ain, UAE.|Zayed Bin Sultan Center for Health Sciences Division, United Arab Emirates University, Al Ain, UAE.
authors.forename: Reham M
authors.initials: RM
authors.lastname: Milhem
authors.affiliation: Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE.
authors.forename: Neena G
authors.initials: NG
authors.lastname: Panicker
authors.affiliation: Zayed Bin Sultan Center for Health Sciences Division, United Arab Emirates University, Al Ain, UAE.|Department of Microbiology and Immunology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE.
authors.forename: Tahir A
authors.initials: TA
authors.lastname: Rizvi
authors.affiliation: Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE.
authors.forename: Farah
authors.initials: F
authors.lastname: Mustafa
mesh_terms: D003101:Collodion / Q000737:chemistry; D004247:DNA / Q000737:chemistry* / Q000235:genetics; D004560:Electricity; D008566:Membranes / Q000737:chemistry; D009841:Oligonucleotides / Q000737:chemistry / Q000235:genetics
chemical_list: D009841:Oligonucleotides; D003101:Collodion; D004247:DNA