title: LAPping up dead cells to prevent lupus nephritis: a novel role for noncanonical autophagy in autoimmunity.
abstract: The mechanisms underlying the development of systemic lupus erythematosus and lupus nephritis remain poorly understood. A recent study demonstrates that deficiencies in the immune system's ability to degrade scavenged dead cells via noncanonical autophagy is sufficient to break immune tolerance and produce features commonly seen in lupus, including circulating autoantibodies, inflammatory cytokines, and nephritis. This work provides a possible mechanism for the association of polymorphisms in autophagy genes with the risk of lupus.
authors.affiliation: Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Renal Division, James J. Peters Bronx Veterans Affairs Medical Center, Bronx, New York, USA. Electronic address: Jeremy.leventhal@mssm.edu.
authors.forename: Jeremy S
authors.initials: JS
authors.lastname: Leventhal
authors.affiliation: Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Renal Division, James J. Peters Bronx Veterans Affairs Medical Center, Bronx, New York, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Ross
mesh_terms: D001323:Autoantibodies / Q000276:immunology; D015551:Autoimmunity / Q000276:immunology*; D001343:Autophagy / Q000235:genetics; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics; D008181:Lupus Nephritis / Q000235:genetics*
chemical_list: D001323:Autoantibodies