title: Relationship between microvessel density and cancer stem cells in tumor angiogenesis: a meta-analysis.
abstract: OBJECTIVE
  Several studies have shown that cancer stem cells (CSCs) promote tumor angiogenesis and are involved in tumor growth. A meta-analysis was conducted to evaluate the association between cancer stem cell markers expression and microvessel density (MVD).
  
  
  METHODS
  Relevant literature was identified from diverse databases. The Stata 12.0 and Review Manager 5.3 software were used to performed meta-analysis.
  
  
  RESULTS
  Sixteen studies investigating the correlation between CSCs and tumor angiogenesis were included in a total of 1409 cases. The result showed that positive CSC markers expression were associated with increased MVD count in human tumors and CSC-transplanted mouse tumor models (p < 0.0001).
  
  
  CONCLUSIONS
  CSCs may be associated with angiogenesis during the growth and development of tumors.
authors.affiliation: Department of Pathology & Key Laboratory for Xinjiang Endemic & Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, Xinjiang, China.
authors.forename: Jiaojiao
authors.initials: J
authors.lastname: Lan
authors.affiliation: Department of Ultrasonic Medicine, The First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Pathology & Key Laboratory for Xinjiang Endemic & Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, Xinjiang, China.
authors.forename: Xinxin
authors.initials: X
authors.lastname: Ju
authors.affiliation: Department of Pathology & Key Laboratory for Xinjiang Endemic & Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, Xinjiang, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Pathology & Key Laboratory for Xinjiang Endemic & Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, Xinjiang, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Qi
authors.affiliation: Department of Pathology & Key Laboratory for Xinjiang Endemic & Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, Xinjiang, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Ren
authors.affiliation: Department of Pathology & Key Laboratory for Xinjiang Endemic & Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, Xinjiang, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zou
authors.affiliation: Department of Pathology & Key Laboratory for Xinjiang Endemic & Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, Xinjiang, China.
authors.forename: Lianghai
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Pathology & Key Laboratory for Xinjiang Endemic & Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, Xinjiang, China.
authors.forename: Man
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Pathology & Key Laboratory for Xinjiang Endemic & Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, Xinjiang, China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Pang
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D016208:Databases, Factual; D004195:Disease Models, Animal; D006801:Humans; D055806:Microvessels / Q000503:physiopathology*; D009369:Neoplasms / Q000473:pathology*; D014411:Neoplastic Stem Cells / Q000166:cytology / Q000378:metabolism*; D009389:Neovascularization, Pathologic; D016017:Odds Ratio; D011379:Prognosis
chemical_list: D015415:Biomarkers
keywords: cancer stem cells; meta-analysis; microvessel density; tumor angiogenesis