title: Antibacterial chitosan/silk sericin 3D porous scaffolds as a wound dressing material.
abstract: Antimicrobial mixed dressings have traditionally been used to minimize bacterial infection of burns and other wounds. This study presents the advancement of biocompatible chitosan/silk sericin (CHT/SS) scaffolds combined with lauric acid (LA) and zinc oxide nanoparticles (nZnO) for the successful wound dressing applications. Antibacterial assay results showed that the diameters of the inhibition zone increased from 2 ± 0.4 to 7 ± 0.1 mm for Escherichia coli, as well as from 2.5 ± 0.2 to 6 ± 0.4 mm for Staphylococcus aureus while CHTS/SS/100nZnO compared to CHT/SS/0.01LA. The results not only showed excellent inhibition against Gram-positive and Gram-negative bacterial growth but also revealed improved proliferation and extended viability for HaCaT cells.
authors.affiliation: a Aksaray University , Faculty of Science and Arts Biology Department , Aksaray , Turkey.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Karahaliloglu
authors.affiliation: b Zonguldak Vocational High School, Bülent Ecevit University , Turkey, Zonguldak.
authors.forename: Ebru
authors.initials: E
authors.lastname: Kilicay
authors.affiliation: c Department of Chemistry, Biochemistry Division , Hacettepe University , Ankara , Turkey.
authors.forename: Emir Baki
authors.initials: EB
authors.lastname: Denkbas
mesh_terms: D001458:Bandages; D002056:Burns / Q000628:therapy; D048271:Chitosan / Q000737:chemistry / Q000494:pharmacology; D007850:Lauric Acids / Q000737:chemistry / Q000494:pharmacology; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use; D016062:Porosity; D047030:Sericins / Q000737:chemistry / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000254:growth & development; D054457:Tissue Scaffolds / Q000737:chemistry*; D015034:Zinc Oxide / Q000737:chemistry / Q000494:pharmacology
chemical_list: D007850:Lauric Acids; D047030:Sericins; C030358:lauric acid; D048271:Chitosan; D015034:Zinc Oxide
keywords: Chitosan; lauric acid; silk sericin; wound dressing; zinc oxide nanoparticles