title: AplusB: A Web Application for Investigating A + B Designs for Phase I Cancer Clinical Trials.
abstract: In phase I cancer clinical trials, the maximum tolerated dose of a new drug is often found by a dose-escalation method known as the A + B design. We have developed an interactive web application, AplusB, which computes and returns exact operating characteristics of A + B trial designs. The application has a graphical user interface (GUI), requires no programming knowledge and is free to access and use on any device that can open an internet browser. A customised report is available for download for each design that contains tabulated operating characteristics and informative plots, which can then be compared with other dose-escalation methods. We present a step-by-step guide on how to use this application and provide several illustrative examples of its capabilities.
authors.affiliation: MRC Biostatistics Unit Hub for Trials Methodology Research, Cambridge Institute of Public Health, Cambridge, United Kingdom.|Cancer Research UK and UCL Cancer Trials Centre, University College London, London, United Kingdom.
authors.forename: Graham M
authors.initials: GM
authors.lastname: Wheeler
authors.affiliation: Cardiovascular Epidemiology Unit, Strangeways Research Laboratory, University of Cambridge, Cambridge, United Kingdom.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Sweeting
authors.affiliation: MRC Biostatistics Unit Hub for Trials Methodology Research, Cambridge Institute of Public Health, Cambridge, United Kingdom.
authors.forename: Adrian P
authors.initials: AP
authors.lastname: Mander
mesh_terms: D017321:Clinical Trials, Phase I as Topic / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D020407:Internet; D020714:Maximum Tolerated Dose; D009369:Neoplasms / Q000188:drug therapy*; D011381:Programming Languages; D012107:Research Design; D014584:User-Computer Interface