title: Methemoglobinemia in a Pediatric Oncology Patient Receiving Sulfamethoxazole/Trimethoprim Prophylaxis.
abstract: BACKGROUND Methemoglobinemia due to the administration of sulfamethoxazole/trimethoprim has been documented in a series of case reports. However, all of these reports are on adult patients, and all patients received at least daily administration of sulfamethoxazole/trimethoprim for the treatment of active or suspected infection. CASE REPORT Herein we report the development of methemoglobinemia in a pediatric patient receiving sulfamethoxazole/trimethoprim three times weekly for the prophylaxis of opportunistic infections. CONCLUSIONS The clinician should always consider sulfamethoxazole/trimethoprim, even when administered for opportunistic infection prophylaxis at reduced doses and intervals, as a possible cause of methemoglobinemia.
authors.affiliation: Department of Pediatrics, Section of Critical Care, University of Oklahoma Health Science Center, Oklahoma City, OK, USA.
authors.forename: Timothy G
authors.initials: TG
authors.lastname: Carroll
authors.affiliation: , Independent Researcher, Oklahoma City, OK, USA.
authors.forename: Megan G
authors.initials: MG
authors.lastname: Carroll
mesh_terms: D006801:Humans; D007223:Infant; D054429:Leukemia, Myelomonocytic, Juvenile / Q000150:complications*; D008297:Male; D008708:Methemoglobinemia / Q000139:chemically induced*; D009894:Opportunistic Infections / Q000209:etiology / Q000517:prevention & control*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D015662:Trimethoprim, Sulfamethoxazole Drug Combination