title: Effects of the DASH-JUMP dietary intervention in Japanese participants with high-normal blood pressure and stage 1 hypertension: an open-label single-arm trial.
abstract: The Dietary Approaches to Stop Hypertension (DASH) diet is recommended by the American Heart Association to lower blood pressure (BP); however, its effects in Japanese participants have not been rigorously studied. We assessed the effects of the DASH-Japan Ube Modified diet Program (DASH-JUMP), a modified DASH diet, on cardiometabolic and inflammatory biomarkers in Japanese participants with untreated high-normal BP or stage 1 hypertension. Fifty-eight participants (30 men and 28 women; mean age 54.1±8.1 years) with untreated high-normal BP or stage 1 hypertension followed the DASH-JUMP (salt 8.0 g per day) for 2 months. After the intervention period, they resumed their usual diets for 4 months. The DASH-JUMP significantly decreased the participants' body mass index values (24.6±3.5 kg m-2at baseline23.2±3.3 kg m-2at 2 months, P=0.000), BP (153±14/91±11 mm Hg at baseline130±16/80±9 mm Hg at 2 months, P=0.000 and 139±16/85±10 mm Hg at 6 months, P=0.000), fasting serum glucose level (100±26 mg dl-194±15 mg dl-1at 2 months, P=0.003) and fasting insulin level (6.9±5.9 μIU ml-14.4±2.7 μIU ml-1at 2 months, P=0.000). The mean compliance of the participants for the DASH-JUMP diet was 88.5%. The DASH-JUMP diet reduced cardiovascular risk factors and may be an effective nutritional strategy for preventing cardiovascular events.
authors.affiliation: Department of Molecular Physiology and Medical Bioregulation, Yamaguchi University Graduate School of Medicine, Ube, Japan.|Faculty of Health Sciences, Yamaguchi University Graduate School of Medicine, Ube, Japan.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Kawamura
authors.affiliation: Department of Molecular Physiology and Medical Bioregulation, Yamaguchi University Graduate School of Medicine, Ube, Japan.
authors.forename: Katsuko
authors.initials: K
authors.lastname: Kajiya
authors.affiliation: Department of Molecular Physiology and Medical Bioregulation, Yamaguchi University Graduate School of Medicine, Ube, Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Kishi
authors.affiliation: Faculty of Health Sciences, Yamaguchi University Graduate School of Medicine, Ube, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Inagaki
authors.affiliation: Central Research Institute, Maruha Nichiro Corporation, Tsukuba, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Mitarai
authors.affiliation: Central Research Institute, Maruha Nichiro Corporation, Tsukuba, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Oda
authors.affiliation: Center for Clinical Research, Yamaguchi University Hospital, Ube, Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Umemoto
authors.affiliation: Department of Molecular Physiology and Medical Bioregulation, Yamaguchi University Graduate School of Medicine, Ube, Japan.
authors.forename: Sei
authors.initials: S
authors.lastname: Kobayashi
mesh_terms: D001786:Blood Glucose; D001794:Blood Pressure / Q000502:physiology*; D015992:Body Mass Index; D005260:Female; D015438:Health Behavior; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000178:diet therapy*; D007328:Insulin / Q000097:blood; D008019:Life Style; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D007328:Insulin