title: Euterpe edulis Extract but Not Oil Enhances Antioxidant Defenses and Protects against Nonalcoholic Fatty Liver Disease Induced by a High-Fat Diet in Rats.
abstract: We investigated the effects of E. edulis bioproducts (lyophilized pulp [LEE], defatted lyophilized pulp [LDEE], and oil [EO]) on nonalcoholic fatty liver disease (NAFLD) induced by a high-fat diet (HFD) in rats. All products were chemically analyzed. In vivo, 42 rats were equally randomized into seven groups receiving standard diet, HFD alone or combined with EO, LEE, or LDEE. After NAFLD induction, LEE, LDEE, or EO was added to the animals' diet for 4 weeks. LEE was rich in polyunsaturated fatty acids. From LEE degreasing, LDEE presented higher levels of anthocyanins and antioxidant capacity in vitro. Dietary intake of LEE and especially LDEE, but not EO, attenuated diet-induced NAFLD, reducing inflammatory infiltrate, steatosis, and lipid peroxidation in liver tissue. Although both E. edulis bioproducts were not hepatotoxic, only LDEE presented sufficient benefits to treat NAFLD in rats, possibly by its low lipid content and high amount of phenols and anthocyanins.
authors.affiliation: Department of Biochemistry and Molecular Biology, Federal University of Viçosa, 36570-000 Viçosa, MG, Brazil.
authors.forename: Rodrigo Barros
authors.initials: RB
authors.lastname: Freitas
authors.affiliation: Department of Structural Biology, Federal University of Alfenas, 37130-000 Alfenas, MG, Brazil.
authors.forename: Rômulo Dias
authors.initials: RD
authors.lastname: Novaes
authors.affiliation: Department of Animal Biology, Federal University of Viçosa, 36570-000 Viçosa, MG, Brazil.
authors.forename: Reggiani Vilela
authors.initials: RV
authors.lastname: Gonçalves
authors.affiliation: Department of Biochemistry and Molecular Biology, Federal University of Viçosa, 36570-000 Viçosa, MG, Brazil.
authors.forename: Bianca Gazolla
authors.initials: BG
authors.lastname: Mendonça
authors.affiliation: School of Medicine, Federal University of Jequitinhonha and Mucuri Valleys, 39100-000 Diamantina, MG, Brazil.
authors.forename: Eliziária Cardoso
authors.initials: EC
authors.lastname: Santos
authors.affiliation: Department of Nutrition and Health, Federal University of Viçosa, 36570-000 Viçosa, MG, Brazil.
authors.forename: Andréia Queiroz
authors.initials: AQ
authors.lastname: Ribeiro
authors.affiliation: Department of Medicine and Nursing, Federal University of Viçosa, 36570-000 Viçosa, MG, Brazil.
authors.forename: Luciana Moreira
authors.initials: LM
authors.lastname: Lima
authors.affiliation: Department of Biochemistry and Molecular Biology, Federal University of Viçosa, 36570-000 Viçosa, MG, Brazil.
authors.forename: Luciano Gomes
authors.initials: LG
authors.lastname: Fietto
authors.affiliation: Department of Nutrition and Health, Federal University of Viçosa, 36570-000 Viçosa, MG, Brazil.
authors.forename: Maria do Carmo Gouveia
authors.initials: Mdo C
authors.lastname: Peluzio
authors.affiliation: Department of Biochemistry and Molecular Biology, Federal University of Viçosa, 36570-000 Viçosa, MG, Brazil.
authors.forename: João Paulo Viana
authors.identifier: 0000-0002-3747-4424
authors.initials: JP
authors.lastname: Leite
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D015415:Biomarkers / Q000378:metabolism; D059305:Diet, High-Fat; D065748:Euterpe / Q000737:chemistry*; D005227:Fatty Acids / Q000032:analysis; D005612:Freeze Drying; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D010084:Oxidation-Reduction; D064209:Phytochemicals / Q000032:analysis; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D010938:Plant Oils / Q000494:pharmacology / Q000627:therapeutic use*; D020011:Protective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D017208:Rats, Wistar; D014810:Vitamin E / Q000032:analysis
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D005227:Fatty Acids; D064209:Phytochemicals; D010936:Plant Extracts; D010938:Plant Oils; D020011:Protective Agents; D014810:Vitamin E