title: Transient Global Amnesia following Neural and Cardiac Angiography May Be Related to Ischemia.
abstract: Introduction. Transient global amnesia (TGA) following angiography is rare, and the pathogenesis has not been illustrated clearly till now. The aim of this research is to explore the pathogenesis of TGA following angiography by analyzing our data and reviewing the literature. Methods. We retrospectively studied 20836 cases with angiography in our hospital between 2007 and 2015 and found 9 cases with TGA following angiography. The data of these 9 cases were analyzed. Results. We found all 9 cases with TGA following neural angiography (5 in 4360) or cardiac angiography (4 in 8817) and no case with TGA following peripheral angiography (0 in 7659). Statistical difference was found when comparing the neural and cardiac angiography group with peripheral group (p = 0.022). Two cases with TGA were confirmed with small acute infarctions in hippocampus after angiography. This might be related to the microemboli which were rushed into vertebral artery following blood flow during neural angiography or cardiac angiography. There was no statistical difference when comparing the different approaches for angiography (p = 0.82) and different contrast agents (p = 0.619). Conclusion. Based on the positive findings of imaging study and our analysis, we speculate that ischemia in the medial temporal lobe with the involvement of the hippocampus might be an important reason of TGA following angiography.
authors.affiliation: Neurosurgical Department, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China.
authors.forename: Hongzhou
authors.identifier: 0000-0002-6456-2307
authors.initials: H
authors.lastname: Duan
authors.affiliation: Neurosurgical Department, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China.
authors.forename: Liang
authors.identifier: 0000-0001-5949-6758
authors.initials: L
authors.lastname: Li
authors.affiliation: Neurosurgical Department, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Neurosurgical Department, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China.
authors.forename: Jiayong
authors.identifier: 0000-0002-3351-2657
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Cardiology Department, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Chen
authors.affiliation: Neurosurgical Department, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China.
authors.forename: Shengde
authors.initials: S
authors.lastname: Bao
mesh_terms: D000328:Adult; D000368:Aged; D020236:Amnesia, Transient Global / Q000209:etiology*; D000792:Angiography / Q000009:adverse effects*; D002545:Brain Ischemia / Q000150:complications*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D013702:Temporal Lobe / Q000473:pathology