title: Interleukin (IL)-39 [IL-23p19/Epstein-Barr virus-induced 3 (Ebi3)] induces differentiation/expansion of neutrophils in lupus-prone mice.
abstract: Interleukin (IL)-12 family cytokines play critical roles in autoimmune diseases. Our previous study has shown that IL-23p19 and Epstein-Barr virus-induced 3 (Ebi3) form a new IL-12 family heterodimer, IL-23p19/Ebi3, termed IL-39, and knock-down of p19 or Ebi3 reduced diseases by transferred GL7+B cells in lupus-prone mice. In the present study, we explore further the possible effect of IL-39 on murine lupus. We found that IL-39 in vitro and in vivo induces differentiation and/or expansion of neutrophils. GL7+B cells up-regulated neutrophils by secreting IL-39, whereas IL-39-deficient GL7+B cells lost the capacity to up-regulate neutrophils in lupus-prone mice and homozygous CD19cre(CD19-deficient) mice. Finally, we found that IL-39-induced neutrophils had a positive feedback on IL-39 expression in activated B cells by secreting B cell activation factor (BAFF). Taken together, our results suggest that IL-39 induces differentiation and/or expansion of neutrophils in lupus-prone mice.
authors.affiliation: Laboratory of Immunology, Institute of Basic Medical Sciences, Beijing, China. wang_renxi@yahoo.com.
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.affiliation: Laboratory of Immunology, Institute of Basic Medical Sciences, Beijing, China.|Department of Nephrology, the 307th Hospital of Chinese People's Liberation Army, Beijing, China.
authors.forename: X
authors.initials: X
authors.lastname: Liu
authors.affiliation: Laboratory of Immunology, Institute of Basic Medical Sciences, Beijing, China.|College of Pharmacy, Henan University, Kaifeng, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Laboratory of Immunology, Institute of Basic Medical Sciences, Beijing, China.|Department of Biomedicine, Institute of Frontier Medical Sciences, School of Pharmaceutical Sciences, Jilin University, Changchun, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Laboratory of Immunology, Institute of Basic Medical Sciences, Beijing, China.|Laboratory of Cellular and Molecular Immunology, Henan University, Kaifeng, Henan, China.
authors.forename: G
authors.initials: G
authors.lastname: Zhu
authors.affiliation: Laboratory of Immunology, Institute of Basic Medical Sciences, Beijing, China.
authors.forename: G
authors.initials: G
authors.lastname: Han
authors.affiliation: Laboratory of Immunology, Institute of Basic Medical Sciences, Beijing, China.
authors.forename: G
authors.initials: G
authors.lastname: Chen
authors.affiliation: Laboratory of Immunology, Institute of Basic Medical Sciences, Beijing, China.
authors.forename: C
authors.initials: C
authors.lastname: Hou
authors.affiliation: College of Pharmacy, Henan University, Kaifeng, China.
authors.forename: T
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Rheumatology, First Hospital of Jilin University, Changchun, China.
authors.forename: N
authors.initials: N
authors.lastname: Ma
authors.affiliation: Laboratory of Immunology, Institute of Basic Medical Sciences, Beijing, China.
authors.forename: B
authors.initials: B
authors.lastname: Shen
authors.affiliation: Laboratory of Immunology, Institute of Basic Medical Sciences, Beijing, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.affiliation: Laboratory of Immunology, Institute of Basic Medical Sciences, Beijing, China. yinher2001@yahoo.com.
authors.forename: H
authors.initials: H
authors.lastname: Xiao
authors.affiliation: Laboratory of Immunology, Institute of Basic Medical Sciences, Beijing, China.
authors.forename: R
authors.initials: R
authors.lastname: Wang
mesh_terms: D000818:Animals; D000943:Antigens, Differentiation / Q000378:metabolism; D053264:B-Cell Activating Factor / Q000378:metabolism; D016175:B-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism; D015415:Biomarkers; D039481:CD11b Antigen / Q000378:metabolism; D002454:Cell Differentiation / Q000276:immunology; D002460:Cell Line; D002478:Cells, Cultured; D005260:Female; D015870:Gene Expression; D053760:Interleukin-23 Subunit p19 / Q000378:metabolism*; D051379:Mice; D019463:Mice, Inbred MRL lpr; D018345:Mice, Knockout; D015778:Minor Histocompatibility Antigens / Q000378:metabolism*; D009504:Neutrophils / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D018121:Receptors, Cytokine / Q000378:metabolism*; D050796:STAT3 Transcription Factor / Q000378:metabolism
chemical_list: D000943:Antigens, Differentiation; D053264:B-Cell Activating Factor; D015415:Biomarkers; D039481:CD11b Antigen; C499601:Ebi3 protein, mouse; D053760:Interleukin-23 Subunit p19; D015778:Minor Histocompatibility Antigens; D018121:Receptors, Cytokine; D050796:STAT3 Transcription Factor; C096712:antigen GL7
keywords: BAFF; IL-39; autoimmune diseases; lupus; neutrophils