title: Electroanalysis of myoglobin based on electropolymerized molecularly imprinted polymer poly-o-phenylenediamine and carbon nanotubes/screen printed electrode.
abstract: Electroanalysis of myoglobin as a marker of acute myocardial infarction by means of screenprinted electrodes modified with multiwalled carbon nanotubes and polymeric artificial antibodies is developed. Plastic antibodies to myoglobin (molecularly imprinted polymers, MIPs) based on o-phenylenediamine were produced by electropolymerization. Molecular imprinting technology in biosensor analysis was used as alternative to natural receptors (namely, antibodies) and demonstrated high sensitivity (1.5 × 10(-2) A/nmol of myoglobin) and selectivity.
authors.affiliation: LLC "IBMC-EcoBioFarm,", Moscow, 119121, Russia. viktoria.shumyantseva@ibmc.msk.ru.|Pirogov Russian National Medical University, Moscow, 117997, Russia. viktoria.shumyantseva@ibmc.msk.ru.|Orekhovich Biomedical Chemistry Institute, Moscow, 119121, Russia. viktoria.shumyantseva@ibmc.msk.ru.
authors.forename: V V
authors.initials: VV
authors.lastname: Shumyantseva
authors.affiliation: LLC "IBMC-EcoBioFarm,", Moscow, 119121, Russia.|Orekhovich Biomedical Chemistry Institute, Moscow, 119121, Russia.
authors.forename: T V
authors.initials: TV
authors.lastname: Bulko
authors.affiliation: Orekhovich Biomedical Chemistry Institute, Moscow, 119121, Russia.|Department of Chemistry, Lomonosov Moscow State University, Moscow, 119991, Russia.
authors.forename: L V
authors.initials: LV
authors.lastname: Sigolaeva
authors.affiliation: LLC "IBMC-EcoBioFarm,", Moscow, 119121, Russia.|Pirogov Russian National Medical University, Moscow, 117997, Russia.|Orekhovich Biomedical Chemistry Institute, Moscow, 119121, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Kuzikov
authors.affiliation: Pirogov Russian National Medical University, Moscow, 117997, Russia.|Orekhovich Biomedical Chemistry Institute, Moscow, 119121, Russia.
authors.forename: A I
authors.initials: AI
authors.lastname: Archakov
mesh_terms: D015415:Biomarkers / Q000097:blood; D015374:Biosensing Techniques / Q000379:methods; D001774:Blood Chemical Analysis / Q000379:methods; D055664:Electrochemical Techniques / Q000295:instrumentation*; D004566:Electrodes; D006801:Humans; D054802:Molecular Imprinting / Q000379:methods; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis; D009211:Myoglobin / Q000032:analysis* / Q000097:blood; D037742:Nanotubes, Carbon; D010655:Phenylenediamines; D011108:Polymers; D012680:Sensitivity and Specificity; D012709:Serum Albumin / Q000737:chemistry; D000075462:Serum Albumin, Human; D012984:Software
chemical_list: D015415:Biomarkers; D009211:Myoglobin; D037742:Nanotubes, Carbon; D010655:Phenylenediamines; D011108:Polymers; D012709:Serum Albumin; C402606:albumin Amsterdam; C530487:poly(o-phenylenediamine); D000075462:Serum Albumin, Human