title: Antagonizing Self-Renewal in Acute Myeloid Leukemia: ID2 Takes the Stage.
abstract: E proteins and their functional antagonists, the ID proteins, have significant roles in normal hematopoiesis. In this issue of Cancer Cell, Ghisi et al. show that high ID2 levels antagonize self-renewal and promote differentiation of leukemic stem cells in the MLL-translocated molecular subtype of acute myeloid leukemia.
authors.affiliation: Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK.
authors.forename: Gauri
authors.initials: G
authors.lastname: Deb
authors.affiliation: Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK. Electronic address: tim.somervaille@cruk.manchester.ac.uk.
authors.forename: Tim C P
authors.initials: TCP
authors.lastname: Somervaille
mesh_terms: D002454:Cell Differentiation; D006412:Hematopoietic Stem Cells / Q000378:metabolism; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D014157:Transcription Factors; D014178:Translocation, Genetic
chemical_list: D014157:Transcription Factors