title: Changes in the prevalence of hospitalization and comorbidity in US adults with stroke: A three decade cross-sectional and birth cohort analysis.
abstract: Little attention was paid to the transition of care for stroke that may partially explain the long-term trend of stroke rates. We aimed to test the trend of hospitalization attributable to stroke in US adults.
  
  
  
  Data from National Hospital Discharge Surveys 1980-2010 in patients aged ≥18 (n = 6,527,304) were analyzed to examine the trend of patients with first-list diagnoses of stroke. Stroke comorbidities were classified in stroke patients with second- to seven-listed diagnoses of coronary heart disease, hypertension, diabetes, arrhythmias, or hyperlipidemia. Stroke trends by survey years and birth cohorts were analyzed using univariate, multivariate, and birth cohorts methods.
  
  
  
  Of the total study sample, the prevalence of hospitalization due to stroke was 22.99%, 30.00%, and 27.03% in years of 1980-1989, 1990-1999, and 2000-2010 in males, and 17.30%, 22.04%, and 19.34% in females, respectively. Overall, hospitalization rates in stroke patients significantly increased among adults aged <65, and decreased in adults aged ≥65. There was an increase in stroke hospitalization rate in the old adults aged ≥65 in recent birth cohorts. Significant increased trends of comorbid hypertension, diabetes, arrhythmias, and hyperlipidemia were observed from 1980 to 2010.
  
  
  
  A significant increase in stroke hospitalization rate was observed in adults aged <65 in the past three decades, and in old adults in recent years. Increases in stroke comorbidity rates were observed in all age groups. Findings from the study highlight that both public health and clinical practices face a serious challenge in controlling this unwelcome increased stroke trend.
authors.affiliation: Department of Epidemiology and Biostatistics, Drexel University Dornsife School of Public Health, Philadelphia, USA Longjian.Liu@Drexel.edu.
authors.forename: Longjian
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Epidemiology and Biostatistics, Drexel University Dornsife School of Public Health, Philadelphia, USA.
authors.forename: Xuan
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Epidemiology and Biostatistics, Drexel University Dornsife School of Public Health, Philadelphia, USA.|Department of Epidemiology, Fourth Military Medical University, Xi'an, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Long
authors.affiliation: Department of Epidemiology and Biostatistics, Drexel University Dornsife School of Public Health, Philadelphia, USA.
authors.forename: Arshpreet Kaur
authors.initials: AK
authors.lastname: Mallhi
authors.affiliation: Department of Epidemiology and Biostatistics, Drexel University Dornsife School of Public Health, Philadelphia, USA.|Department of Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, USA.
authors.forename: Kathan
authors.initials: K
authors.lastname: Mehta
authors.affiliation: Drexel Neurosciences Institute and Department of Neurosurgery, Drexel University College of Medicine, Philadelphia, USA.
authors.forename: Erol
authors.initials: E
authors.lastname: Veznedaroglu
authors.affiliation: Department of Medicine, University of Pennsylvania, Philadelphia, USA.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Yin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015331:Cohort Studies; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D006760:Hospitalization / Q000639:trends*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D020521:Stroke / Q000150:complications / Q000453:epidemiology* / Q000628:therapy*; D014481:United States / Q000453:epidemiology; D055815:Young Adult
keywords: Stroke; a three-decade trend; birth cohorts