title: Injectable formulations of poly(lactic acid) and its copolymers in clinical use.
abstract: Poly(lactic acid) and its copolymers have revolutionized the field of drug delivery due to their excellent biocompatibility and tunable physico-chemical properties. These copolymers have served the healthcare sector by contributing many products to combat various diseases and for biomedical applications. This article provides a comprehensive overview of clinically used products of poly(lactic acid) and its copolymers. Multi-dimension information covering product approval, formulation aspects and clinical status is described to provide a panoramic overview of each product. Moreover, leading patented technologies and various clinical trials on these products for different applications are included. This review focuses on marketed injectable formulations of PLA and its copolymers.
authors.affiliation: Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500037, India.
authors.forename: Anjali
authors.initials: A
authors.lastname: Jain
authors.affiliation: School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel.
authors.forename: Konda Reddy
authors.initials: KR
authors.lastname: Kunduru
authors.affiliation: School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel.
authors.forename: Arijit
authors.initials: A
authors.lastname: Basu
authors.affiliation: Faculty of Biotechnology and Food Engineering, Technion, Haifa 32000, Israel.
authors.forename: Boaz
authors.initials: B
authors.lastname: Mizrahi
authors.affiliation: School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel. Electronic address: avid@ekmd.huji.ac.il.
authors.forename: Abraham J
authors.initials: AJ
authors.lastname: Domb
authors.affiliation: Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500037, India. Electronic address: wahid@niperhyd.ac.in.
authors.forename: Wahid
authors.initials: W
authors.lastname: Khan
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D004337:Drug Carriers / Q000008:administration & dosage* / Q000737:chemistry*; D006801:Humans; D007267:Injections; D008863:Microspheres; D010330:Patents as Topic; D011091:Polyesters / Q000008:administration & dosage* / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D011091:Polyesters; C033616:poly(lactide)
keywords: Injectable depot; Microspheres; PLA clinical products; PLA copolymers; Poly(lactic acid)