title: The level of cytokines and expression of caspase genes in rheumatoid arthritis.
abstract: The level of TNFα and IL6 in the blood plasma of patients with rheumatoid arthritis (RA) who received antiinflammatory therapy with methotrexate (MT) was significantly lower than in the patients without MT treatment. The level of caspase 6 and 9 gene transcripts in peripheral blood lymphocytes in patients with rheumatoid arthritic diagnosed for the first time and in patients with MT treatment were not significantly different. At the same time, the level of caspase 3 mRNA expression was significantly higher in the cells of the RA patients with MT therapy compared to the patients without MT therapy.
authors.affiliation: Institute of Biology, Karelian Research Center, Russian Academy of Sciences, ul. Pushkinskaya 11, Petrozavodsk, 185910, Karelia, Russia. i.e.malysheva@yandex.ru.
authors.forename: I E
authors.initials: IE
authors.lastname: Malysheva
authors.affiliation: Institute of Biology, Karelian Research Center, Russian Academy of Sciences, ul. Pushkinskaya 11, Petrozavodsk, 185910, Karelia, Russia.
authors.forename: L V
authors.initials: LV
authors.lastname: Topchieva
authors.affiliation: Petrozavodsk State University, pr. Lenina 33, Petrozavodsk, Karelia, 185910, Russia.
authors.forename: O Y
authors.initials: OY
authors.lastname: Barysheva
authors.affiliation: Institute of Biology, Karelian Research Center, Russian Academy of Sciences, ul. Pushkinskaya 11, Petrozavodsk, 185910, Karelia, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Kurbatova
authors.affiliation: Petrozavodsk State University, pr. Lenina 33, Petrozavodsk, Karelia, 185910, Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Vasykova
authors.affiliation: Petrozavodsk State University, pr. Lenina 33, Petrozavodsk, Karelia, 185910, Russia.
authors.forename: N N
authors.initials: NN
authors.lastname: Vezikova
authors.affiliation: Petrozavodsk State University, pr. Lenina 33, Petrozavodsk, Karelia, 185910, Russia.
authors.forename: I M
authors.initials: IM
authors.lastname: Marusenko
authors.affiliation: Institute of Biology, Karelian Research Center, Russian Academy of Sciences, ul. Pushkinskaya 11, Petrozavodsk, 185910, Karelia, Russia.
authors.forename: N N
authors.initials: NN
authors.lastname: Nemova
mesh_terms: D018501:Antirheumatic Agents / Q000494:pharmacology; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000188:drug therapy; D015415:Biomarkers / Q000097:blood; D053148:Caspase 3 / Q000097:blood*; D053178:Caspase 6 / Q000097:blood*; D053453:Caspase 9 / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008214:Lymphocytes / Q000378:metabolism; D008727:Methotrexate / Q000494:pharmacology; D012333:RNA, Messenger / Q000378:metabolism; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D018501:Antirheumatic Agents; D015415:Biomarkers; C508600:IL6 protein, human; D015850:Interleukin-6; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha; C505407:CASP3 protein, human; C505514:CASP6 protein, human; C506433:CASP9 protein, human; D053148:Caspase 3; D053178:Caspase 6; D053453:Caspase 9; D008727:Methotrexate