title: Patient-Specific Computational Models of Coronary Arteries Using Monoplane X-Ray Angiograms.
abstract: Coronary artery disease (CAD) is the most common type of heart disease in western countries. Early detection and diagnosis of CAD is quintessential to preventing mortality and subsequent complications. We believe hemodynamic data derived from patient-specific computational models could facilitate more accurate prediction of the risk of atherosclerosis. We introduce a semiautomated method to build 3D patient-specific coronary vessel models from 2D monoplane angiogram images. The main contribution of the method is a robust segmentation approach using dynamic programming combined with iterative 3D reconstruction to build 3D mesh models of the coronary vessels. Results indicate the accuracy and robustness of the proposed pipeline. In conclusion, patient-specific modelling of coronary vessels is of vital importance for developing accurate computational flow models and studying the hemodynamic effects of the presence of plaques on the arterial walls, resulting in lumen stenoses, as well as variations in the angulations of the coronary arteries.
authors.affiliation: School of Medicine, University of California, San Diego, CA 92093, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Zifan
authors.affiliation: Department of Electrical Engineering, The Petroleum Institute, P.O. Box 2533, Abu Dhabi, UAE.
authors.forename: Panos
authors.identifier: 0000-0002-5490-6030
authors.initials: P
authors.lastname: Liatsis
mesh_terms: D000792:Angiography / Q000379:methods*; D001808:Blood Vessels / Q000503:physiopathology; D003198:Computer Simulation; D003331:Coronary Vessels / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional; D010363:Pattern Recognition, Automated; D012372:ROC Curve; D011857:Radiographic Image Interpretation, Computer-Assisted; D012984:Software; D014965:X-Rays