title: Outgroups and Positive Selection: The Nothobranchius furzeri Case.
abstract: Applications of positive selection analysis increase with the number of species for which genome/transcriptome sequences become available. Using the recently sequenced turquoise killifish (Nothobranchius furzeri) genome as an example, we compare two different approaches based on different outgroup selection. The combination of these two methods allows the origin of positively selected sites in aging-related genes of the N. furzeri genome to be determined.
authors.affiliation: Leibniz Institute on Aging, Fritz Lipmann Institute, Jena, Germany.
authors.forename: Arne
authors.initials: A
authors.lastname: Sahm
authors.affiliation: Leibniz Institute on Aging, Fritz Lipmann Institute, Jena, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Platzer
authors.affiliation: Leibniz Institute on Aging, Fritz Lipmann Institute, Jena, Germany; Laboratory of Biology Bio@SNS, Scuola Normale Superiore, Pisa, Italy. Electronic address: alessandro.cellerino@sns.it.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Cellerino
mesh_terms: D000818:Animals; D023781:Fundulidae / Q000235:genetics*; D016678:Genome; D010802:Phylogeny; D012641:Selection, Genetic / Q000235:genetics*; D059467:Transcriptome / Q000235:genetics*