title: Association of interleukin-10 gene promoter polymorphisms with recurrent miscarriage: a meta-analysis.
abstract: The association between IL-10 gene promoter polymorphisms and the risk of recurrent miscarriages (RM) remains controversial. The present meta-analysis was performed to derive a precise estimate of the relationship.
  
  
  
  We searched the PubMed and EMBASE for studies related to the association between the IL-10 gene polymorphism and the risk of RM. Summary odds ratio (OR) with 95% confidence interval (CI) was estimated to assess the associations.
  
  
  
  Thirteen studies, including 2047 RM cases and 2055 control samples, were identified. The results showed a significant association between rs1800896, rs1800871 and RM risk (for rs1800896: GA+GG vs AA: OR=1.20, 95% CI=1.04-1.39, P=.02; for rs1800871: CT+TT vs CC: OR=1.64, 95% CI=1.13-2.36, P=.009). No evidence of association was noted between rs1800872 haplotype and RM risk.
  
  
  
  IL-10 gene promoter polymorphisms, rs1800896 and rs1800871, play a potential role in increasing the risk of RM.
authors.affiliation: Department of Gynecology and Obstetrics, Bethune International Peace Hospital, Shijiazhuang, Hebei Province, China.
authors.forename: Duo
authors.initials: D
authors.lastname: Su
authors.affiliation: College of Pharmacy, Second Military Medical University, Shanghai, China.
authors.forename: Yeye
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Gynecology and Obstetrics, Bethune International Peace Hospital, Shijiazhuang, Hebei Province, China.
authors.forename: Qingqin
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Emergency, People's Hospital, Cixian, Hebei Province, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Gynecology and Obstetrics, Bethune International Peace Hospital, Shijiazhuang, Hebei Province, China.
authors.forename: Baoquan
authors.initials: B
authors.lastname: Jiao
authors.affiliation: Laboratory of Physiology, Second Military Medical University, Shanghai, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Gynecology and Obstetrics, Bethune International Peace Hospital, Shijiazhuang, Hebei Province, China.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Wu
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics* / Q000276:immunology; D000328:Adult; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics* / Q000276:immunology; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D012307:Risk Factors
chemical_list: C508609:IL10 protein, human; D016753:Interleukin-10
keywords: gene polymorphism; interleukin-10; meta-analysis; recurrent miscarriage