title: Towards Intravenous Drug Delivery: Augmenting the Stability and Dispersity of Bis-Demethoxy Curcumin Analog by Bottom-Up Strategy.
abstract: Intravenous route is the best strategy to accomplish fastest and highest delivery of drugs. Hydrophobic drugs like curcumin and its analog exhibit disadvantages like low bioavailability, poor absorption and rapid precipitation on intravenous delivery, all leading to its poor therapeutic value. These can be by-passed by enhancing the dispersity, stability and decreasing the size of the drug by nanotization. Thus, with an intention to deliver bis-demethoxy curcumin analog via intravenous route, we have studied the effect of DMSO, ethanol and acetone on the size, size distribution, stability and yield and identified the best solvent in terms of smallest size, narrow size distribution, more stability and high yield of nano bis-demethoxy curcumin analog (NBDMCA). NBDMCA prepared using DMSO showed the lowest mean particle size cum polydispersity index and highest zeta potential when compared to ethanol and acetone. Hence the DMSO based formulation can provide prolonged action and better efficacy at minimal doses. Thus, the DMSO based NBDMCA can emerge as an ideal therapeutic tool for human use.
authors.forename: Arul Prakash
authors.initials: AP
authors.lastname: Francis
authors.forename: Sundara
authors.initials: S
authors.lastname: Ramaprabhu
authors.forename: Thiyagarajan
authors.initials: T
authors.lastname: Devasena
mesh_terms: D061605:Administration, Intravenous; D003474:Curcumin / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods*; D004355:Drug Stability; D006801:Humans
chemical_list: D003474:Curcumin