title: Comparison of Choi criteria and Response Evaluation Criteria in Solid Tumors (RECIST) for intrahepatic cholangiocarcinoma treated with glass-microspheres Yttrium-90 selective internal radiation therapy (SIRT).
abstract: OBJECTIVE
  To compare Choi criteria with Response Evaluation Criteria in Solid Tumors (RECIST) for the prediction of overall survival (OS) in patients treated with glass-microspheres, Yttrium-90 selective internal radiation therapy (SIRT) for intrahepatic cholangiocarcinoma (ICC).
  
  
  METHODS
  Between 2010 and 2014, 45 adult patients with locally advanced ICC treated with SIRT were retrospectively analyzed. Computed tomography scans performed before and after treatment were analyzed using both RECIST 1.1 and Choi criteria. Response was correlated with survival.
  
  
  RESULTS
  Patients who achieved an objective response according to Choi had a longer OS than non-responders (median OS 19.9 months [95% CI, 1.1-38.7 months] vs. 7.5 months if stable disease [uncountable CI] and 3 months if progressive disease [95% CI, 0-6.2 months], log-rank test: p=0.003) whereas there was no significant survival difference according to the RECIST response (p=0.339). Among the 39 RECIST non-responding patients, those identified as responders by Choi (n=31) had significantly better OS than Choi non-responders (median OS 19.9 months (95% CI, 5.1-34.7 months) and 5.4 months (95% CI, 0-11.6 months), p=0.005).
  
  
  CONCLUSIONS
  Choi criteria appear more appropriate than RECIST to identify responders with long survival among patients who received SIRT for ICC.
authors.affiliation: Department of Radiology, Rennes University Hospital, 2 Rue Henri Le Guilloux, 35000 Rennes, France. Electronic address: lucbeuzit@yahoo.fr.
authors.forename: Luc
authors.initials: L
authors.lastname: Beuzit
authors.affiliation: Department of Medical Oncology, Comprehensive Cancer Center, Institute Eugène Marquis, Rennes, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Edeline
authors.affiliation: Department of Radiology, Rennes University Hospital, 2 Rue Henri Le Guilloux, 35000 Rennes, France.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Brun
authors.affiliation: Department of Radiology, Beaujon University Hospital, Assistance Publique Hopitaux de Paris, Clichy, France.
authors.forename: Maxime
authors.initials: M
authors.lastname: Ronot
authors.affiliation: Department of Hepatology, Rennes University Hospital, Rennes, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Guillygomarc'h
authors.affiliation: Department of Digestive Surgery, Rennes University Hospital, Rennes, France.
authors.forename: Karim
authors.initials: K
authors.lastname: Boudjema
authors.affiliation: Department of Radiology, Rennes University Hospital, 2 Rue Henri Le Guilloux, 35000 Rennes, France.
authors.forename: Yves
authors.initials: Y
authors.lastname: Gandon
authors.affiliation: Department of Nuclear Medicine, Comprehensive Cancer Center, Institute Eugène Marquis, Rennes, France.
authors.forename: Etienne
authors.initials: E
authors.lastname: Garin
authors.affiliation: Department of Radiology, Comprehensive Cancer Center, Institute Eugène Marquis, Rennes, France.
authors.forename: Yan
authors.initials: Y
authors.lastname: Rolland
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001650:Bile Duct Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D001918:Brachytherapy / Q000379:methods*; D018281:Cholangiocarcinoma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008297:Male; D008863:Microspheres; D008875:Middle Aged; D066066:Response Evaluation Criteria in Solid Tumors; D012189:Retrospective Studies; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome; D015021:Yttrium Radioisotopes / Q000627:therapeutic use*
chemical_list: D015021:Yttrium Radioisotopes
keywords: CT; Choi criteria; Cholangiocarcinoma; Response Evaluation Criteria in Solid Tumors (RECIST); Selective internal radiation therapy (SIRT); Treatment outcome