title: [Impact of opiates on dopaminergic neurons].
abstract: Since the work of Johnson and North, it is known that opiates increase the activity of dopaminergic neurons by a GABA neuron-mediated desinhibition. This model should however be updated based on recent advances. Thus, the neuroanatomical location of the GABA neurons responsible for this desinhibition has been recently detailed: they belong to a brain structure in continuity with the posterior part of the ventral tegmental area and discovered this past decade. Other data also highlighted the critical role played by glutamatergic transmission in the opioid regulation of dopaminergic neuron activity. During protracted opiate withdrawal, the inhibitory/excitatory balance exerted on dopaminergic neurons is altered. These results are now leading to propose an original hypothesis for explaining the impact of protracted opiate withdrawal on mood.
authors.affiliation: MRC Brain network dynamics unit, université d'Oxford, Mansfield road, Oxford OX1 3TH, Royaume-Uni.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Kaufling
authors.affiliation: Institut des neurosciences cellulaires et intégratives, UPR3212 CNRS, 5, rue Blaise Pascal, 67084 Strasbourg, France - Université de Strasbourg, France.
authors.forename: Marie-José
authors.initials: MJ
authors.lastname: Freund-Mercier
authors.affiliation: Institut des neurosciences cellulaires et intégratives, UPR3212 CNRS, 5, rue Blaise Pascal, 67084 Strasbourg, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Barrot
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology; D059290:Dopaminergic Neurons / Q000187:drug effects* / Q000502:physiology; D059330:GABAergic Neurons / Q000187:drug effects / Q000502:physiology; D006801:Humans; D053610:Opiate Alkaloids / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects; D017557:Ventral Tegmental Area / Q000187:drug effects / Q000502:physiology
chemical_list: D053610:Opiate Alkaloids