title: Assessing the global threat from Zika virus.
abstract: First discovered in 1947, Zika virus (ZIKV) infection remained a little-known tropical disease until 2015, when its apparent association with a considerable increase in the incidence of microcephaly in Brazil raised alarms worldwide. There is limited information on the key factors that determine the extent of the global threat from ZIKV infection and resulting complications. Here, we review what is known about the epidemiology, natural history, and public health effects of ZIKV infection, the empirical basis for this knowledge, and the critical knowledge gaps that need to be filled.
authors.affiliation: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. justin@jhu.edu.
authors.forename: Justin
authors.initials: J
authors.lastname: Lessler
authors.affiliation: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
authors.forename: Lelia H
authors.initials: LH
authors.lastname: Chaisson
authors.affiliation: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Lauren M
authors.initials: LM
authors.lastname: Kucirka
authors.affiliation: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
authors.forename: Qifang
authors.initials: Q
authors.lastname: Bi
authors.affiliation: Department of Biology, Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA.
authors.forename: Kyra
authors.initials: K
authors.lastname: Grantz
authors.affiliation: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Mathematical Modelling of Infectious Diseases Unit, Institut Pasteur, Paris, France.
authors.forename: Henrik
authors.initials: H
authors.lastname: Salje
authors.affiliation: Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
authors.forename: Andrea C
authors.initials: AC
authors.lastname: Carcelen
authors.affiliation: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
authors.forename: Cassandra T
authors.initials: CT
authors.lastname: Ott
authors.affiliation: Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Jeanne S
authors.initials: JS
authors.lastname: Sheffield
authors.affiliation: Department of Medicine, School of Public Health, Imperial College London, London, UK.
authors.forename: Neil M
authors.initials: NM
authors.lastname: Ferguson
authors.affiliation: Department of Biology, Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA.
authors.forename: Derek A T
authors.initials: DA
authors.lastname: Cummings
authors.affiliation: Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA. Office of Population Research, Princeton University, Princeton, NJ, USA.
authors.forename: C Jessica E
authors.initials: CJ
authors.lastname: Metcalf
authors.affiliation: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
authors.forename: Isabel
authors.initials: I
authors.lastname: Rodriguez-Barraquer
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000639:trends; D001938:Brazil; D003465:Culex / Q000821:virology; D015195:Drug Design; D005260:Female; D014943:Global Health; D006801:Humans; D015994:Incidence; D008831:Microcephaly / Q000821:virology*; D010802:Phylogeny; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology; D011634:Public Health; D000071244:Zika Virus / Q000145:classification / Q000472:pathogenicity / Q000502:physiology; D000071243:Zika Virus Infection / Q000150:complications / Q000517:prevention & control* / Q000635:transmission*