title: Exploiting DNA repair defects for novel cancer therapies.
abstract: Most human tumors accumulate a multitude of genetic changes due to defects in the DNA damage response. Recently, small-molecule inhibitors have been developed that target cells with specific DNA repair defects, providing hope for precision treatment of such tumors. Here we discuss the rationale behind these therapies and how an important bottleneck-patient selection-can be approached.
authors.affiliation: Department of Molecular Genetics, Cancer Genomics Netherlands, Erasmus University Medical Center, Rotterdam 3015, Netherlands.
authors.forename: Dik C
authors.initials: DC
authors.lastname: van Gent
authors.affiliation: Department of Molecular Genetics, Cancer Genomics Netherlands, Erasmus University Medical Center, Rotterdam 3015, Netherlands Department of Radiation Oncology, Erasmus University Medical Center, Rotterdam 3015, Netherlands r.kanaar@erasmusmc.nl.
authors.forename: Roland
authors.initials: R
authors.lastname: Kanaar
mesh_terms: D053903:DNA Breaks, Double-Stranded; D004249:DNA Damage; D004260:DNA Repair; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000628:therapy*; D018579:Patient Selection; D057285:Precision Medicine / Q000379:methods