title: Human Papillomavirus Entry: Hiding in a Bubble.
abstract: Incoming human papillomavirus (HPV) utilize vesicular transport to traffic from the plasma membrane to the trans-Golgi network. Following nuclear envelope breakdown during mitosis, the viral DNA associates with condensed chromosomes utilizing spindle microtubules for delivery. Most intriguingly, the viral DNA resides in a transport vesicle until mitosis is completed and the nuclear envelope has reformed. This finding provides support for the transient existence of nuclear membrane-bound vesicles. Due to their transient nature, it also points to the existence of a cell pathway for the disposal of vesicles ending up fortuitously or purposefully in the nucleus.
authors.affiliation: Department of Microbiology and Immunology, Center for Molecular and Tumor Virology, Feist-Weiller Cancer Center, LSU Health Shreveport, Shreveport, Louisiana, USA.
authors.forename: Stephen
authors.initials: S
authors.lastname: DiGiuseppe
authors.affiliation: Department of Microbiology and Immunology, Center for Molecular and Tumor Virology, Feist-Weiller Cancer Center, LSU Health Shreveport, Shreveport, Louisiana, USA.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Bienkowska-Haba
authors.affiliation: Department of Microbiology and Immunology, Center for Molecular and Tumor Virology, Feist-Weiller Cancer Center, LSU Health Shreveport, Shreveport, Louisiana, USA msapp1@lsuhsc.edu.
authors.forename: Martin
authors.initials: M
authors.lastname: Sapp
mesh_terms: D022162:Cytoplasmic Vesicles / Q000821:virology; D004705:Endocytosis; D006801:Humans; D027383:Papillomaviridae / Q000502:physiology*; D053586:Virus Internalization