title: The Role of Flecainide in the Management of Catecholaminergic Polymorphic Ventricular Tachycardia.
abstract: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare but severe genetic cardiac arrhythmia disorder, with symptoms including syncope and sudden cardiac death due to polymorphic VT or ventricular fibrillation typically triggered by exercise or emotions in the absence of structural heart disease. The cornerstone of medical therapy for CPVT is β-blockers. However, recently flecainide has been added to the therapeutic arsenal for CPVT. In this review we summarise current data on the efficacy and role of flecainide in the treatment of CPVT.
authors.affiliation: Heart Centre, Academic Medical Centre, Amsterdam, The Netherlands.
authors.forename: Krystien Vv
authors.initials: KV
authors.lastname: Lieve
authors.affiliation: Heart Centre, Academic Medical Centre, Amsterdam, The Netherlands; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders, Jeddah, Kingdom of Saudi Arabia.
authors.forename: Arthur A
authors.initials: AA
authors.lastname: Wilde
authors.affiliation: Heart Centre, Academic Medical Centre, Amsterdam, The Netherlands.
authors.forename: Christian
authors.initials: C
authors.lastname: van der Werf
keywords: Antiarrhythmic therapy; catecholaminergic ventricular tachycardia; flecainide; genetic; inherited channelopathies; sudden death