title: Executive Summary of the Guidelines for the Use of interferon-gamma Release Assays in the Diagnosis of Tuberculosis Infection.
abstract: Interferon-gamma release assays are widely used for the diagnosis of tuberculosis infection in Spain. However, there is no consensus on their application in specific clinical scenarios. To develop a guide-line for their use, a panel of experts comprising specialists in infectious diseases, respiratory diseases, microbiology, pediatrics and preventive medicine, together with a methodologist, conducted a systematic literature search, summarized the findings, rated the quality of the evidence, and formulated recommendations following the Grading of Recommendations of Assessment Development and Evaluations methodology. This document provides evidence-based guidance on the use of interferon-gamma release assays for the diagnosis of tuberculosis infection in patients at risk of tuberculosis or suspected of having active disease. The guidelines will be applicable to specialist and primary care, and public health.
authors.affiliation: Servicio de Enfermedades Infecciosas, Hospital Universitario de Bellvitge-IDIBELL, L'Hospitalet de Llobregat, Barcelona, España; Departamento de Ciencias Clínicas, Universidad de Barcelona, Barcelona, España.
authors.forename: Miguel
authors.initials: M
authors.lastname: Santin
authors.affiliation: Unidad de Gestión Clínica de Neumología, Hospital San Agustín, Avilés, Asturias, España.
authors.forename: José-María
authors.initials: JM
authors.lastname: García-García
authors.affiliation: Centro Cochrane Iberoamericano-Instituto de Investigación Biomédica Sant Pau (IIB Sant Pau), Barcelona, España.
authors.forename: David
authors.initials: D
authors.lastname: Rigau
authors.affiliation: Unidad de Tuberculosis Valle de Hebrón, Instituto de Investigación en Atención Primaria Jordi Gol, Unidad Clínica de Tratamiento Directamente Observado «Servicios Clínicos», Barcelona, España.
authors.forename: Neus
authors.initials: N
authors.lastname: Altet
authors.affiliation: Unidad de Tuberculosis, Enfermedades Infecciosas, Servicio de Medicina Interna, Complexo Hospitalario de Pontevedra, Pontevedra, España.
authors.forename: Luis
authors.initials: L
authors.lastname: Anibarro
authors.affiliation: Servicio de Medicina Preventiva, Hospital Germans Trias i Pujol , Badalona, Barcelona, España; Departamento de Pediatría, Obstetricia-Ginecología y Medicina Preventiva, Universidad Autónoma de Barcelona, Barcelona, España.
authors.forename: Irma
authors.initials: I
authors.lastname: Casas
authors.affiliation: Servicio de Pediatría, Hospital Universitario Rio Hortega, Valladolid, España.
authors.forename: Nuria
authors.initials: N
authors.lastname: Díez
authors.affiliation: Servicio de Medicina Interna/ Enfermedades Infecciosas, Hospital Son Llàtzer, Palma de Mallorca, España.
authors.forename: Mercedes
authors.initials: M
authors.lastname: García-Gasalla
authors.affiliation: Unidad de Control de la Tuberculosis, Hospital Universitario Mutua de Terrassa, Terrassa, Barcelona, España.
authors.forename: Xavier
authors.initials: X
authors.lastname: Martínez-Lacasa
authors.affiliation: Unidad de Tuberculosis, Servicio de Neumología, Hospital Universitario Lucus Augusti, Lugo, España.
authors.forename: Antón
authors.initials: A
authors.lastname: Penas
authors.affiliation: Servicio de Medicina Interna, Enfermedades Infecciosas, Hospital de Jerez, Jerez de la Frontera, Cádiz, España.
authors.forename: Elvira
authors.initials: E
authors.lastname: Pérez-Escolano
authors.affiliation: Servicio de Enfermedades Infecciosas, Instituto Mar de Investigaciones Médicas (IMIM), Hospital del Mar, Barcelona, España.
authors.forename: Francisca
authors.initials: F
authors.lastname: Sánchez
authors.affiliation: Servicio de Microbiología, Institut d'Investigació Germans Trias i Pujol; Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, España; Departament de Genètica i Microbiologia, Universitat Autònoma de Barcelona, Badalona, Barcelona, España; CIBER Enfermedades Respiratorias, Badalona, Barcelona, España. Electronic address: jadomb@gmail.com.
authors.forename: José
authors.initials: J
authors.lastname: Domínguez
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D016358:Contact Tracing; D004797:Enzyme-Linked Immunosorbent Assay; D019317:Evidence-Based Medicine; D015658:HIV Infections / Q000150:complications; D006801:Humans; D007223:Infant; D059425:Interferon-gamma Release Tests / Q000592:standards*; D008403:Mass Screening; D016377:Organ Transplantation; D011300:Preoperative Care; D013030:Spain; D014376:Tuberculosis / Q000150:complications / Q000175:diagnosis*
keywords: Guideline; Guía de uso en la práctica clínica; Infección tuberculosa latente; Interferon-gamma release assays; Latent tuberculosis infection; Prevención; Prevention; Pruebas de liberación de interferón-gamma; Tuberculosis