title: Assessment of infarct-specific cardiac motion dysfunction using modeling and multimodal magnetic resonance merging.
abstract: To propose a cardiac motion tracking model that evaluates wall motion abnormality in postmyocardial infarction patients. Correlation between the motion parameter of the model and left ventricle (LV) function was also determined.
  
  
  
  Twelve male patients with post-ST elevation myocardial infarction (post-STEMI) and 10 healthy controls of the same gender were recruited to undergo cardiac magnetic resonance imaging (MRI) using a 1.5T scanner. Using an infarct-specific LV division approach, the late gadolinium enhancement (LGE) MRI images were used to divide the LV on the tagged MRI images into infarct, adjacent, and remote sectors. Motion tracking was performed using the infarct-specific two-parameter empirical deformable model (TPEDM). The match quality was defined as the position error computed using root-mean-square (RMS) distance between the estimated and expert-verified tag intersections. The position errors were compared with the ones from our previously published fixed-sector TPEDM. Cine MRI images were used to calculate regional ejection fraction (REF). Correlation between the end-systolic contraction parameter (αES) with REF was determined.
  
  
  
  The position errors in the proposed model were significantly lower than the fixed-sector model (P < 0.01). The median position errors were 0.82 mm versus 1.23 mm. The αEScorrelates significantly with REF (r = 0.91, P < 0.01).
  
  
  
  The infarct-specific TPEDM combines the morphological and functional information from LGE and tagged MRI images. It was shown to outperform the fixed-sector model in assessing regional LV dysfunction. The significant correlation between αESand REF added prognostic value because it indicated an impairment of cardiac function with the increase of infarct transmurality.
  
  
  
  3 J. Magn. Reson. Imaging 2017;45:525-534.
authors.affiliation: Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Chen Onn
authors.initials: CO
authors.lastname: Leong
authors.affiliation: Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Yih Miin
authors.initials: YM
authors.lastname: Liew
authors.affiliation: Biophysics Department, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Bilgen
authors.affiliation: Department of Biomedical Imaging, University Malaya Research Imaging Centre, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Yang Faridah
authors.initials: YF
authors.lastname: Abdul Aziz
authors.affiliation: Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Kok Han
authors.initials: KH
authors.lastname: Chee
authors.affiliation: Department of Software Engineering, Faculty of Computer Science & Information Technology, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Yin Kia
authors.initials: YK
authors.lastname: Chiam
authors.affiliation: Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Einly
authors.initials: E
authors.lastname: Lim
mesh_terms: D003198:Computer Simulation; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D009038:Motion; D009068:Movement; D064847:Multimodal Imaging / Q000379:methods; D009203:Myocardial Infarction / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology*
keywords: LV motion analysis; cardiac modeling; late gadolinium enhancement; myocardial infarction; tagged MRI