title: Physical role for the nucleus in cell migration.
abstract: Cell migration is important for the function of many eukaryotic cells. Recently the nucleus has been shown to play an important role in cell motility. After giving an overview of cell motility mechanisms we review what is currently known about the mechanical properties of the nucleus and the connections between it and the cytoskeleton. We also discuss connections to the extracellular matrix and mechanotransduction. We identify key physical roles of the nucleus in cell migration.
authors.affiliation: Department of Physics and Astronomy, University of Sheffield, Hicks Building, Hounsfield Road, Sheffield S3 7RH, UK.
authors.forename: Antoine
authors.initials: A
authors.lastname: Fruleux
authors.forename: Rhoda J
authors.initials: RJ
authors.lastname: Hawkins
mesh_terms: D002465:Cell Movement; D002467:Cell Nucleus; D003599:Cytoskeleton; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D008954:Models, Biological; D013314:Stress, Mechanical