title: Resveratrol attenuated estrogen-deficient-induced cardiac dysfunction: role of AMPK, SIRT1, and mitochondrial function.
abstract: Large epidemiological studies suggest that there are important differences in the incidence and severity of a wide variety of cardiac diseases, between premenopausal and menopausal women. Recently, it has been demonstrated that resveratrol may has similar function as estrogen. However, whether resveratrol replacement could mimic estrogen to protect heart in ovariectomized mice remains completely unknown. Firstly, the present study has used OVX/CAL model to investigate the effect of RSV on ischemic heart. Echocardiography analysis revealed that RSV administration significantly improved cardiac contractile function in estrogen-deficient mice. RSV also significantly reduced CK and LDH release, and heart infarct size in OVX/CAL group. Secondly, mitochondrial functions, including MRC activities, MDA level, and mitochondrial swelling, were evaluated in OVX mice. It was found that supplementation with RSV could restore mitochondrial function dampened by OVX. Thirdly, these protective functions mediated by RSV were mainly attributed to the enhancement of SIRT1/AMPK activity. In summary, the results support a potential role of resveratrol in the protection of cardiac functions under estrogen depletion status.
authors.affiliation: Experimental Teaching Center of Preventive Medicine, School of Public Health and Tropical Medicine, Southern Medical University Guangzhou, Guangdong 510515, China.
authors.forename: Zijun
authors.initials: Z
authors.lastname: Meng
authors.affiliation: Department of Clinical Nutrition, Air Force General Hospital (PLA) No.30 Fucheng Road, District of Haidian, Beijing 100142, China.
authors.forename: Hongjiang
authors.initials: H
authors.lastname: Jing
authors.affiliation: Experimental Teaching Center of Preventive Medicine, School of Public Health and Tropical Medicine, Southern Medical University Guangzhou, Guangdong 510515, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Gan
authors.affiliation: Experimental Teaching Center of Preventive Medicine, School of Public Health and Tropical Medicine, Southern Medical University Guangzhou, Guangdong 510515, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Li
authors.affiliation: Experimental Teaching Center of Preventive Medicine, School of Public Health and Tropical Medicine, Southern Medical University Guangzhou, Guangdong 510515, China.
authors.forename: Bingde
authors.initials: B
authors.lastname: Luo
keywords: AMPK; Resveratrol; SIRT1; heart; ischemia; mitochondrion