title: [Effect of treatment with diet on reducing levels of sex hormones in perimenopausal women with overweight and obesity].
abstract: Nowadays, fight against obesity is a big challenge for the developed countries. Perimenopausal women are especially prone to becoming overweight and obese. This is due to changes in hormone levels and alterations in the sex hormones synthesis pathway.
  
  
  OBJECTIVE
  The aim of this study was to evaluate the levels of sex hormones in overweight and obese women during menopause following the three month period of reducing diet.
  
  
  METHODS
  The study involved women aged 55±4,75 years. Group I - 33 overweight women (BMI 28,06±1,00 kg/m(2)). Group II - 32 obese women (BMI 34,22±3,79 kg/m(2)). Anthropometric measurements, body composition tested with Bodystat QuadScan 4000 analyzer and levels of sex hormones in the blood was determined before and after the three-months of reducing diet in both groups. Statistical data analysis was performed.
  
  
  RESULTS
  After three-months of reducing diet it was noticed that levels of BMI, body fat, FSH, DHEA-S and androstenedione were decreased in a statistically significant manner. A significant increase in estradiol levels after reduction of visceral adipose tissue in both groups, overweight and obese women, was observed. However, only in the group of obese women, a decrease in BMI correlated with a significant increase in estradiol levels.
  
  
  CONCLUSIONS
  Application of appropriate reducing diet in perimenopausal overweight and obese women has positive impact on visceral adipose tissue distribution and causes an increase in sex hormones levels. Perimenopausal overweight and obese women should pursue weight reduction to improve their chances of contracting cardiovascular diseases.
authors.affiliation: Medical University of Lodz, Poland: Department of Clinical Nutrition and Gastroenterology Diagnostics.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Łokieć
authors.affiliation: Medical University of Lodz, Poland: Department of Clinical Nutrition and Gastroenterology Diagnostics.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Błońska
authors.affiliation: Medical University of Lodz, Poland: Department of Gastroenterology.
authors.forename: Ewa
authors.initials: E
authors.lastname: Walecka-Kapica
authors.affiliation: Medical University of Lodz, Poland: Department of Gastroenterology.
authors.forename: Krystyna
authors.initials: K
authors.lastname: Stec-Michalska
mesh_terms: D000273:Adipose Tissue; D000368:Aged; D001823:Body Composition; D015992:Body Mass Index; D004038:Diet, Reducing; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000178:diet therapy*; D050177:Overweight / Q000097:blood / Q000178:diet therapy*; D047648:Perimenopause
chemical_list: D012739:Gonadal Steroid Hormones
keywords: menopause; obesity; reducing diet; sex hormones