title: [High sensitivity T troponin and CA-125 as prognostic biomarkers in patients with end stage renal disease in hemodialysis].
abstract: BACKGROUND
  The end stage renal disease confers a high morbidity and mortality risk, mainly due to cardiovascular disease. The cardiac T troponin and carbohydrate antigen-125 (CA-125) are useful biomarkers to determine cardiovascular prognosis in order to start preventive treatment in the high risk patients.
  
  
  METHODS
  We included patients with end stage renal disease in hemodialysis treatment. Plasma high sensitivity cardiac T troponin (hs-TNT) and CA-125 were measured at the beginning of follow up. The patients with clinical evidence of an acute myocardial infarction were excluded. Twelve month after the measurement of the biomarkers the patients were called to assess the occurrence of major adverse cardiovascular events (MACE) and hospitalizations for any reason.
  
  
  RESULTS
  Eighty seven patients were included. The mean age was 5815 years, and 76% were male. The hs-TNT was elevated in 95.4% of the patients and the median value was 49 ng/l (15.3 - 214.1). CA-125 median value was 13.7 U/ml (6.1 - 52.7). The patients that presented a MACE had higher CA-125 (p< 0.03) and hs-TNT (p <0.001); and all of them had a troponin value ≥ 69.37 ng/l.
  
  
  CONCLUSIONS
  The prevalence of high hs-TNT was 95.4% and of CA-125 10%. MACE were significantly higher in patients with elevated biomarkers, conferring them prognostic utility in this group of patients.
authors.affiliation: Servicio de Cardiología, Sanatorio Allende Nueva Córdoba, Córdoba, Argentina.
authors.forename: Juan S
authors.initials: JS
authors.lastname: Moreno
authors.affiliation: Servicio de Cardiología, Sanatorio Allende Nueva Córdoba, Córdoba, Argentina.
authors.forename: Augusto J
authors.initials: AJ
authors.lastname: Lépori
authors.affiliation: Servicio de Nefrología, Sanatorio Allende Nueva Córdoba, Córdoba, Argentina.
authors.forename: Pablo
authors.initials: P
authors.lastname: Novoa
authors.affiliation: Laboratorio central, Sanatorio Allende Nueva Córdoba, Córdoba, Argentina.
authors.forename: Rafael
authors.initials: R
authors.lastname: De Elia
authors.affiliation: Laboratorio central, Sanatorio Allende Nueva Córdoba, Córdoba, Argentina.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Guglielmone
authors.affiliation: Servicio de Cardiología, Sanatorio Allende Nueva Córdoba, Córdoba, Argentina.
authors.forename: Julio P
authors.initials: JP
authors.lastname: Bono
mesh_terms: D015415:Biomarkers / Q000097:blood; D018394:CA-125 Antigen / Q000097:blood*; D002318:Cardiovascular Diseases / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D006435:Renal Dialysis; D012680:Sensitivity and Specificity; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; D018394:CA-125 Antigen; D020107:Troponin T