title: [Toxicity associated with EGRF inhibition: review and key aspects in the management of afatinib].
abstract: Afatinib is an irreversible tyrosine kinase inhibitor of the ErbB family, approved for the treatment of patients with non-small cell lung cancer with EGFR-sensitizing mutations. Like other EGFR inhibitors, afatinib can provoke adverse events such as diarrhoea, rash, paronychia or mucositis. The correct management of these adverse events is essential to maintain quality of life in these patients and obtain the maximum benefit from afatinib therapy. This study aimed to review the toxicity of the drug and summarize recommendations for the prevention and treatment of the most significant adverse events associated with afatinib.
authors.affiliation: Servicio de Oncología Médica, Hospital del Mar, IMIM (Instituto Hospital del Mar de Investigaciones Médicas), Barcelona, España. Electronic address: ataus@parcdesalutmar.cat.
authors.forename: Álvaro
authors.initials: Á
authors.lastname: Taus
mesh_terms: D000077716:Afatinib; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000037:antagonists & inhibitors* / Q000235:genetics; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D066246:ErbB Receptors / Q000037:antagonists & inhibitors* / Q000235:genetics; D018815:Genes, erbB; D005819:Genetic Markers; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D009154:Mutation; D047428:Protein Kinase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D011799:Quinazolines / Q000009:adverse effects* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D005819:Genetic Markers; D047428:Protein Kinase Inhibitors; D011799:Quinazolines; D000077716:Afatinib; D066246:ErbB Receptors
keywords: Adverse effects; Afatinib; Cáncer de pulmón; EGFR; Efectos adversos; Lung cancer; Toxicidad; Toxicity