title: A systematic review of factors affecting intended and actual adherence with antiviral medication as treatment or prophylaxis in seasonal and pandemic flu.
abstract: The aim of this review was to identify factors predicting actual or intended adherence to antivirals as treatment or prophylaxis for influenza. Literature from inception to March 2015 was systematically reviewed to find studies reporting predictors of adherence to antivirals and self-reported reasons for non-adherence to antivirals. Twenty-six studies were included in the review; twenty identified through the literature search and six through other means. Of these studies, 18 assessed predictors of actual adherence to antivirals, whereas eight assessed predictors of intended adherence. The most commonly found predictor of, and self-reported reason for, non-adherence was the occurrence of side effects. Other predictors include perceptions surrounding self-efficacy, response efficacy and perceived personal consequences as well as social influences of others' experiences of taking antivirals. Predictors identified in this review can be used to help inform communications to increase adherence to antivirals in both seasonal and pandemic influenza.
authors.affiliation: Department of Psychological Medicine, King's College London, London, UK.
authors.forename: Louise E
authors.identifier: 0000-0002-1277-2564
authors.initials: LE
authors.lastname: Smith
authors.affiliation: Institute of Pharmaceutical Science, King's College London, London, UK.
authors.forename: Donatella
authors.initials: D
authors.lastname: D'Antoni
authors.affiliation: Department of Psychological Medicine, King's College London, London, UK.
authors.forename: Vageesh
authors.initials: V
authors.lastname: Jain
authors.affiliation: Department of War Studies, King's College London, London, UK.
authors.forename: Julia M
authors.initials: JM
authors.lastname: Pearce
authors.affiliation: Institute of Pharmaceutical Science, King's College London, London, UK.
authors.forename: John
authors.initials: J
authors.lastname: Weinman
authors.affiliation: Department of Psychological Medicine, King's College London, London, UK. Gideon.rubin@kcl.ac.uk.
authors.forename: G James
authors.initials: GJ
authors.lastname: Rubin
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D004196:Disease Outbreaks / Q000517:prevention & control*; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D007251:Influenza, Human / Q000188:drug therapy* / Q000453:epidemiology / Q000517:prevention & control* / Q000821:virology; D055118:Medication Adherence; D058873:Pandemics / Q000517:prevention & control; D012621:Seasons
chemical_list: D000998:Antiviral Agents
keywords: adherence; antivirals; influenza; pandemic