title: Formation of adhesion after intraperitoneal application of TiMesh: experimental study on a rodent model.
abstract: BACKGROUND
  After laparoscopic repair of an incisive hernia, intraperitoneal prosthetic mesh, as a foreign material, is a strong stimulus for the development of adhesion, which may be the cause of serious complications. This experimental study compared three different meshes and their ability to prevent the formation of adhesion and shrinkage.
  
  
  METHODS
  Ninety rats were divided randomly into three groups: in Group 1 Proceed mesh was implanted, in Group 2 Ultrapro mesh was implanted, and in Group 3 TiMesh was implanted. Mesh samples were fixed as an intraabdominal mesh in the upper part of the abdomen. Ten animals from each group were sacrificed on days 7, 28 and 60 post-surgery. After opening the abdomen, the formation of adhesion was assessed according to the Surgical Membrane Study Group (SMSG) score, the percentage of shrinkage of the mesh was established and inflammatory reaction scored.
  
  
  RESULTS
  The SMSG score for adhesion was statistically significantly higher on all the postoperative days in the Proceed and Ultrapro mesh groups than in the TiMesh group which caused milder inflammatory reaction on 60th day than others meshes. The size of the mesh after 7 days was statistically significantly smaller in the Proceed and Ultrapro groups than in the TiMesh group, but after 60 days it was statistically significantly larger than in the TiMesh group.
  
  
  CONCLUSIONS
  The least formation of adhesion was noted in the TiMesh group, in which the highest level of shrinkage was noticed after 28 and 60 days. TiMesh has advantages over the other meshes studied, but a larger size mesh may be recommended for intraperitoneal application.
authors.affiliation: a Department of Surgery , University Clinical Centre , Tuzla , Bosnia and Herzegovina.|b Faculty of Medicine , University of Tuzla , Tuzla, Bosnia and Herzegovina.
authors.forename: Samir
authors.initials: S
authors.lastname: Delibegovic
authors.affiliation: c Cantonal Hospital Zenica , Tuzla, Bosnia and Herzegovina.
authors.forename: Anhel
authors.initials: A
authors.lastname: Koluh
authors.affiliation: b Faculty of Medicine , University of Tuzla , Tuzla, Bosnia and Herzegovina.|d Clinic for Pathology, University Clinical Centre , Tuzla , Bosnia and Herzegovina.
authors.forename: Elmir
authors.initials: E
authors.lastname: Cickusic
authors.affiliation: e Veterinary Faculty , University of Sarajevo , Tuzla, Bosnia and Herzegovina.
authors.forename: Muhamed
authors.initials: M
authors.lastname: Katica
authors.affiliation: d Clinic for Pathology, University Clinical Centre , Tuzla , Bosnia and Herzegovina.
authors.forename: Jasminka
authors.initials: J
authors.lastname: Mustedanagic
authors.affiliation: f Department of Orthopaedics, Institute of Clinical Sciences , Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden.
authors.forename: Ferid
authors.initials: F
authors.lastname: Krupic
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001707:Biopsy, Needle; D005260:Female; D007150:Immunohistochemistry; D008297:Male; D023421:Models, Animal; D010529:Peritoneal Cavity / Q000601:surgery*; D019919:Prosthesis Implantation / Q000009:adverse effects / Q000379:methods*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013526:Surgical Mesh / Q000009:adverse effects*; D000267:Tissue Adhesions / Q000209:etiology* / Q000473:pathology*
keywords: Abdomen; adhesion; hernia; laparoscopic repair; mesh; shrinkage