title: Comparative evaluation of the wound-healing potency of recombinant bFGF and ski gene therapy in rats.
abstract: We previously demonstrated that cellular Sloan-Kettering Institute (c-Ski) played a dual role, both promoting wound healing and alleviating scar formation. However, its mechanism and therapeutic effects are not clear, especially compared with widely used treatments, such as basic fibroblast growth factor (bFGF) administration. However, Ski treatment led to an even shorter healing time and a more significant reduction in scar area than bFGF treatment. The mechanism underlying this difference was related to a reduced inflammatory response, more rapid re-epithelialization, less collagen after healing and a greater reduction in the proportion of alpha-smooth muscle actin and SMemb-positive cells after Ski treatment. These results not only confirm that Ski plays a dual role in promoting healing and reducing scarring but also suggest that Ski yields better treatment effects than bFGF, indicating better potential therapeutic effects in wound repair.
authors.affiliation: a The Molecular Biology Centre, State Key Laboratory of Trauma Burn and Combined Injury, Research Institute of Surgery and Daping Hospital, Third Military Medical University , Chongqing , China and.
authors.forename: Yan
authors.initials: Y
authors.lastname: Peng
authors.affiliation: a The Molecular Biology Centre, State Key Laboratory of Trauma Burn and Combined Injury, Research Institute of Surgery and Daping Hospital, Third Military Medical University , Chongqing , China and.
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.affiliation: a The Molecular Biology Centre, State Key Laboratory of Trauma Burn and Combined Injury, Research Institute of Surgery and Daping Hospital, Third Military Medical University , Chongqing , China and.
authors.forename: Zi-Ai
authors.initials: ZA
authors.lastname: Zhao
authors.affiliation: a The Molecular Biology Centre, State Key Laboratory of Trauma Burn and Combined Injury, Research Institute of Surgery and Daping Hospital, Third Military Medical University , Chongqing , China and.
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
authors.affiliation: a The Molecular Biology Centre, State Key Laboratory of Trauma Burn and Combined Injury, Research Institute of Surgery and Daping Hospital, Third Military Medical University , Chongqing , China and.
authors.forename: Xiao-Guang
authors.initials: XG
authors.lastname: Zhao
authors.affiliation: a The Molecular Biology Centre, State Key Laboratory of Trauma Burn and Combined Injury, Research Institute of Surgery and Daping Hospital, Third Military Medical University , Chongqing , China and.
authors.forename: Xing
authors.initials: X
authors.lastname: Chen
authors.affiliation: a The Molecular Biology Centre, State Key Laboratory of Trauma Burn and Combined Injury, Research Institute of Surgery and Daping Hospital, Third Military Medical University , Chongqing , China and.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: a The Molecular Biology Centre, State Key Laboratory of Trauma Burn and Combined Injury, Research Institute of Surgery and Daping Hospital, Third Military Medical University , Chongqing , China and.
authors.forename: Ren-Ping
authors.initials: RP
authors.lastname: Xiong
authors.affiliation: a The Molecular Biology Centre, State Key Laboratory of Trauma Burn and Combined Injury, Research Institute of Surgery and Daping Hospital, Third Military Medical University , Chongqing , China and.
authors.forename: Ya-Lei
authors.initials: YL
authors.lastname: Ning
authors.affiliation: a The Molecular Biology Centre, State Key Laboratory of Trauma Burn and Combined Injury, Research Institute of Surgery and Daping Hospital, Third Military Medical University , Chongqing , China and.
authors.forename: Nan
authors.initials: N
authors.lastname: Yang
authors.affiliation: b Department of Ophthalmology , Research Institute of Surgery and Daping Hospital, Third Military Medical University , Chongqing , China.
authors.forename: Jian
authors.initials: J
authors.lastname: Ye
authors.affiliation: a The Molecular Biology Centre, State Key Laboratory of Trauma Burn and Combined Injury, Research Institute of Surgery and Daping Hospital, Third Military Medical University , Chongqing , China and.
authors.forename: Yuan-Guo
authors.initials: YG
authors.lastname: Zhou
mesh_terms: D000199:Actins / Q000235:genetics / Q000378:metabolism; D000818:Animals; D003094:Collagen / Q000235:genetics / Q000378:metabolism; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology*; D015316:Genetic Therapy / Q000009:adverse effects / Q000379:methods*; D008297:Male; D011518:Proto-Oncogene Proteins / Q000235:genetics* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D011994:Recombinant Proteins; D014945:Wound Healing / Q000187:drug effects / Q000235:genetics*
chemical_list: D000199:Actins; D011518:Proto-Oncogene Proteins; D011994:Recombinant Proteins; C525545:Ski protein, rat; D016222:Fibroblast Growth Factor 2; D003094:Collagen
keywords: Ski; bFGF; skin; wound healing