title: Intestinal microbiota transplant - current state of knowledge.
abstract: Faecal microbiota transplantation (FMT) has induced a lot scientific interest and hopes for the last couple of years. FMT has been approved as a treatment of recurrent Clostridium difficile colitis. Highly sophisticated molecular DNA identification methods have been used to assess the healthy human microbiome as well as its disturbances in several diseases. The metabolic and immunologic functions of the microbiome have become more clear and understandable. A lot of pathological changes, such as production of short-chain fatty acids or components of the inflammatory cascade, caused by changes in microbiome diversity, variability and richness have been observed among patients suffering from inflammatory bowel diseases, irritable bowel syndrome, type 2 diabetes or rheumatoid arthritis. The published clinical results are encouraging, but still there is huge demand for FMT controlled clinical trials.
authors.affiliation: National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland; Biotransplant Research, Wroclaw, Poland.
authors.forename: Jarosław Jerzy
authors.initials: JJ
authors.lastname: Leszczyszyn
authors.affiliation: National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland; School of Pharmacy and Pharmaceutical Sciences, University of Dublin, Trinity College, Dublin, Ireland.
authors.forename: Marek
authors.initials: M
authors.lastname: Radomski
authors.affiliation: Department of Oral Surgery, Medical University in Wroclaw, Wroclaw, Poland.
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Leszczyszyn
keywords: faecal microbiota transplantation; inflammatory bowel disease; microbiome