title: Serum Levels of Albumin-β-Amyloid Complex in Patients with Depression.
abstract: Epidemiologic studies have demonstrated that suffering from depression may be a risk for Alzheimer disease (AD). As a possible biologic mechanism underlying the transition from depression to AD, it has been speculated that pathologic changes in β-amyloid (Aβ) metabolism are involved. To further understand the peripheral kinetics of amyloid in patients with depression, we investigated serum levels of free Aβ and albumin-bound Aβ.
  
  
  
  Seventy inpatients with DSM-IV major depressive disorder (MDD) and 81 healthy individuals (the comparison group) were recruited between June 2012 and February 2014. Serum Aβ40 and Aβ42 levels, Aβ40/Aβ42 ratio, and serum levels of albumin-Aβ complexes (SLAACs) were compared between the comparison group and patients in two age groups comprising younger (<60 years) and elderly (≥60 years) people.
  
  
  
  SLAAC was decreased in older patients with MDD but not in younger patients. The serum-free Aβ40/Aβ42 ratio was higher in patients with depression, even in younger patients.
  
  
  
  Our findings suggest that free Aβ and the albumin-bound Aβ reflect a different serum amyloid kinetics in depression. We speculate that serum-free Aβ reflects changes in amyloid metabolism in patients suffering from depression and albumin-bound Aβ reflects AD pathology and may be a potential predictor of the prodromal stage of AD.
authors.affiliation: Juntendo University Mood Disorder Project, Department of Psychiatry, Juntendo Koshigaya Hospital, Saitama, Japan; Department of Psychiatry & Behavioral Science, Juntendo Graduate School of Medicine, Tokyo, Japan.
authors.forename: Megumi
authors.initials: M
authors.lastname: Inoue
authors.affiliation: Juntendo University Mood Disorder Project, Department of Psychiatry, Juntendo Koshigaya Hospital, Saitama, Japan; Department of Psychiatry & Behavioral Science, Juntendo Graduate School of Medicine, Tokyo, Japan. Electronic address: hbaba@juntendo.ac.jp.
authors.forename: Hajime
authors.initials: H
authors.lastname: Baba
authors.affiliation: Departments of Geriatric Medicine and Neurology and Hematology, Osaka City University Graduate School of Medicine, Osaka, Japan.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Yamamoto
authors.affiliation: Departments of Geriatric Medicine and Neurology and Hematology, Osaka City University Graduate School of Medicine, Osaka, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Shimada
authors.affiliation: Departments of Geriatric Medicine and Neurology and Hematology, Osaka City University Graduate School of Medicine, Osaka, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Yamakawa
authors.affiliation: Juntendo University Mood Disorder Project, Department of Psychiatry, Juntendo Koshigaya Hospital, Saitama, Japan; Department of Psychiatry & Behavioral Science, Juntendo Graduate School of Medicine, Tokyo, Japan.
authors.forename: Toshihito
authors.initials: T
authors.lastname: Suzuki
authors.affiliation: Departments of Geriatric Medicine and Neurology and Hematology, Osaka City University Graduate School of Medicine, Osaka, Japan.
authors.forename: Takami
authors.initials: T
authors.lastname: Miki
authors.affiliation: Department of Psychiatry & Behavioral Science, Juntendo Graduate School of Medicine, Tokyo, Japan.
authors.forename: Heii
authors.initials: H
authors.lastname: Arai
mesh_terms: D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis / Q000378:metabolism / Q000523:psychology; D016229:Amyloid beta-Peptides / Q000032:analysis / Q000097:blood / Q000378:metabolism; D003865:Major Depressive Disorder / Q000097:blood / Q000175:diagnosis / Q000523:psychology; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000032:analysis / Q000097:blood / Q000378:metabolism; D062706:Prodromal Symptoms; D011379:Prognosis; D013223:Statistics as Topic
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C538897:amyloid beta-protein (40-42)
keywords: Alzheimer disease; Depression; albumin; amyloid; serum