title: First isolation of Candida wangnamkhiaoensis from the blood of immunocompromised paediatric patient.
abstract: Candida wangnamkhiaoensis is a species clustered under the Hyphopichia clade has not ever been isolated from any clinical specimens. To the best of our knowledge, this is the first report of C. wangnamkhiaoensis associated with fungaemia in immunocompromised paediatric patient. The isolate was assigned a strain name as UZ1679/14, in which the identification was confirmed by a polymerase chain reaction-sequencing of the internal transcribed spacer (ITS) and large subunit (LSU) regions of the rRNA gene. Antifungal susceptibility pattern showed that the isolate was sensitive to anidulafungin, caspofungin, fluconazole and voriconazole. The patient clinically improved after the antifungal treatment with caspofungin.
authors.affiliation: Bacteriology Unit, Infectious Diseases Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia. ratna@imr.gov.my.
authors.forename: Ratna Mohd
authors.initials: RM
authors.lastname: Tap
authors.affiliation: Haematology-Oncology Unit, Paediatric Department, Sarawak General Hospital, Kuching, Sarawak, Malaysia.
authors.forename: Lee Sue
authors.initials: LS
authors.lastname: Ho Betty
authors.affiliation: Bacteriology Unit, Infectious Diseases Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia.
authors.forename: Nur Yasmin
authors.initials: NY
authors.lastname: Ramli
authors.affiliation: Virology Unit, Infectious Diseases Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia.
authors.forename: Jeyanthi
authors.initials: J
authors.lastname: Suppiah
authors.affiliation: Bacteriology Unit, Infectious Diseases Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia.
authors.forename: Rohaidah
authors.initials: R
authors.lastname: Hashim
authors.affiliation: Bacteriology Unit, Infectious Diseases Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia.
authors.forename: Parameswari
authors.initials: P
authors.lastname: Sabaratnam
authors.affiliation: Bacteriology Unit, Infectious Diseases Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia.
authors.forename: Stephanie Jane
authors.initials: SJ
authors.lastname: Ginsapu
authors.affiliation: Microbiology Unit, Pathology Department, Sarawak General Hospital, Kuching, Sarawak, Malaysia.
authors.forename: Annabel
authors.initials: A
authors.lastname: Gowbei
authors.affiliation: Bacteriology Unit, Infectious Diseases Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia.
authors.forename: Mohd Fuat Abd
authors.initials: MF
authors.lastname: Razak
authors.affiliation: Department of Genetics and Applied Microbiology, University of Debrecen, Debrecen, Hungary.
authors.forename: Matthias
authors.initials: M
authors.lastname: Sipiczki
authors.affiliation: Bacteriology Unit, Infectious Diseases Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia.
authors.forename: Norazah
authors.initials: N
authors.lastname: Ahmad
mesh_terms: D000077612:Anidulafungin; D000935:Antifungal Agents / Q000494:pharmacology; D002175:Candida / Q000145:classification / Q000235:genetics / Q000302:isolation & purification* / Q000648:ultrastructure; D058387:Candidemia / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology*; D000077336:Caspofungin; D002675:Child, Preschool; D021903:DNA, Ribosomal Spacer; D054714:Echinocandins / Q000494:pharmacology / Q000627:therapeutic use; D015725:Fluconazole / Q000494:pharmacology; D006801:Humans; D025301:Hyphae / Q000302:isolation & purification / Q000648:ultrastructure; D016867:Immunocompromised Host; D055666:Lipopeptides / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D016415:Sequence Alignment; D065819:Voriconazole / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D021903:DNA, Ribosomal Spacer; D054714:Echinocandins; D055666:Lipopeptides; D015725:Fluconazole; D000077612:Anidulafungin; D000077336:Caspofungin; D065819:Voriconazole
keywords: 
  Candida wangnamkhiaoensis
  ; 
  Hypopichia clade
  ; fungaemia; immunocompromised patient