title: Hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) with primary or secondary cytoreductive surgery in the treatment of advanced epithelial ovarian cancer.
abstract: BACKGROUND
  Peritoneal dissemination is the most common route of spread of epithelial ovarian cancer (EOC). Cytoreductive surgery (CRS) followed by platinum-based systemic chemotherapy is the current standard treatment in advanced stages, with suboptimal results. The aim of this study is to analyze the outcome of advanced EOC treated with CRS plus hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) combined with systemic chemotherapy.
  
  
  METHODS
  We analyze a cohort of women treated with CRS plus HIPEC for peritoneal carcinomatosis secondary to EOC from May 2007 to December 2014. We included both patients with peritoneal disease at first diagnosis of EOC and peritoneal recurrences after initial treatment.
  
  
  RESULTS
  We performed 61 CRS with HIPEC procedures, 31 cases as primary treatment (4 as upfront therapy and 27 after neoadjuvant chemotherapy) and 30 as secondary treatment (recurrences). Median Peritoneal Carcinomatosis Index (PCI) was 9; the cytoreduction was optimal in 92% of the procedures. Severe morbidity (Grade III-IV of Clavien-Dindo classification) was 29.5%, without mortality. Median follow-up was 23 months and median disease-free survival (DFS) was 14 months (14 in primary surgery group and 17 in recurrence group, P=0.51). Median overall survival (OS) was 57 months; in primary surgery group, OS was 96.8% at 1 year, and 55% at 5 years, and median OS was not reached; OS in recurrence group was 89.3% at 1 year and 47.1% at 5 years, and median OS was 57 months.
  
  
  CONCLUSIONS
  CRS with HIPEC is a treatment option for EOC with good results in terms of morbidity and survival, in experienced centers.
authors.affiliation: Peritoneal Carcinomatosis Unit, Department of General and Digestive Surgery, Fuenlabrada University Hospital, Fuenlabrada, Madrid, Spain - israel.manzanedo@salud.madrid.org.
authors.forename: Israel
authors.initials: I
authors.lastname: Manzanedo
authors.affiliation: Peritoneal Carcinomatosis Unit, Department of General and Digestive Surgery, Fuenlabrada University Hospital, Fuenlabrada, Madrid, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Pereira
authors.affiliation: Peritoneal Carcinomatosis Unit, Department of General and Digestive Surgery, Fuenlabrada University Hospital, Fuenlabrada, Madrid, Spain.
authors.forename: Estíbalitz
authors.initials: E
authors.lastname: Pérez-Viejo
authors.affiliation: Peritoneal Carcinomatosis Unit, Department of General and Digestive Surgery, Fuenlabrada University Hospital, Fuenlabrada, Madrid, Spain.
authors.forename: Ángel
authors.initials: Á
authors.lastname: Serrano
authors.affiliation: Department of General and Digestive Surgery, Fuenlabrada University Hospital, Fuenlabrada, Madrid, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Hernández-García
authors.affiliation: Department of General and Digestive Surgery, Fuenlabrada University Hospital, Fuenlabrada, Madrid, Spain.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Martínez-Torres
authors.affiliation: Department of General and Digestive Surgery, Fuenlabrada University Hospital, Fuenlabrada, Madrid, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Rihuete-Caro
authors.affiliation: Department of Medical Oncology, Fuenlabrada University Hospital, Fuenlabrada, Madrid, Spain.
authors.forename: Julia
authors.initials: J
authors.lastname: Calzas
authors.affiliation: Department of Obstetrics and Gynecology, Fuenlabrada University Hospital, Fuenlabrada, Madrid, Spain.
authors.forename: Margarita
authors.initials: M
authors.lastname: Cueto
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D000077216:Carcinoma, Ovarian Epithelial; D015331:Cohort Studies; D003131:Combined Modality Therapy; D065426:Cytoreduction Surgical Procedures / Q000379:methods*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007274:Injections, Intraperitoneal; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000379:methods; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D009375:Neoplasms, Glandular and Epithelial / Q000473:pathology / Q000628:therapy*; D010051:Ovarian Neoplasms / Q000473:pathology / Q000628:therapy*; D010534:Peritoneal Neoplasms / Q000473:pathology / Q000556:secondary / Q000628:therapy*; D011446:Prospective Studies; D015996:Survival Rate