title: Fatal Pancreatic Necrosis after Pregnancy-Associated Thrombotic Thrombocytopenic Purpura.
abstract: Thrombotic thrombocytopenic purpura (TTP) is a systemic disease characterised by the presence of microvascular thrombi resulting from endothelial injury and platelet activation. Vascular occlusion leads to the clinical manifestations of ischaemicorgan damage, microangiopathic haemolytic anaemia and thrombocytopenia. Pancreatitis has rarely been described in association with TTP and has not been reported with TTP in pregnancy. We describe a case of pancreatic necrosis due to TTP which presented in the third trimester of pregnancy and we review the literature relating to this rare complication.
authors.affiliation: a Department of Haematology , St James's Hospital and Trinity College , Dublin , Ireland.|c Department of Intensive Care , St James's Hospital and Trinity College , Dublin , Ireland.
authors.forename: N
authors.initials: N
authors.lastname: O'Connell
authors.affiliation: a Department of Haematology , St James's Hospital and Trinity College , Dublin , Ireland.|c Department of Intensive Care , St James's Hospital and Trinity College , Dublin , Ireland.
authors.forename: M P
authors.initials: MP
authors.lastname: Martin-Hernandez
authors.affiliation: a Department of Haematology , St James's Hospital and Trinity College , Dublin , Ireland.|c Department of Intensive Care , St James's Hospital and Trinity College , Dublin , Ireland.
authors.forename: J
authors.initials: J
authors.lastname: Chacko
authors.affiliation: a Department of Haematology , St James's Hospital and Trinity College , Dublin , Ireland.|c Department of Intensive Care , St James's Hospital and Trinity College , Dublin , Ireland.
authors.forename: C
authors.initials: C
authors.lastname: Duggan
authors.affiliation: b Department of Histopathology , St James's Hospital and Trinity College , Dublin , Ireland.|c Department of Intensive Care , St James's Hospital and Trinity College , Dublin , Ireland.
authors.forename: D S
authors.initials: DS
authors.lastname: O'Briain
authors.affiliation: a Department of Haematology , St James's Hospital and Trinity College , Dublin , Ireland.|c Department of Intensive Care , St James's Hospital and Trinity College , Dublin , Ireland.
authors.forename: J
authors.initials: J
authors.lastname: Moriarty
authors.affiliation: a Department of Haematology , St James's Hospital and Trinity College , Dublin , Ireland.|c Department of Intensive Care , St James's Hospital and Trinity College , Dublin , Ireland.
authors.forename: P V
authors.initials: PV
authors.lastname: Browne
authors.affiliation: a Department of Haematology , St James's Hospital and Trinity College , Dublin , Ireland.|c Department of Intensive Care , St James's Hospital and Trinity College , Dublin , Ireland.
authors.forename: S R
authors.initials: SR
authors.lastname: Mc Cann
keywords: Thrombotic thrombocytopenic purpura; pancreatitis; plasma exchange; pregnancy