title: Lectin-like Oxidized Low-Density Lipoprotein (LDL) Receptor (LOX-1): A Chameleon Receptor for Oxidized LDL.
abstract: LOX-1, one of the main receptors for oxLDL, is found mainly on the surface of endothelial cells. It is a multifacet 52 kDa type II transmembrane protein that structurally belongs to the C-type lectin family. It exists with short intracellular N-terminal and long extracellular C-terminal hydrophilic domains separated by a hydrophobic domain of 26 amino acids. LOX-1 acts like a bifunctional receptor either showing pro-atherogenicity by activating the NFκB-mediated down signaling cascade for gene activation of pro-inflammatory molecules or playing an atheroprotective agent by receptor-mediated uptake of oxLDL in the presence of an anti-inflammatory molecule like IL-10. Mildly, moderately, and highly oxidized LDL show their characteristic features upon LOX-1 activation and its ligand binding indenture. The polymorphic LOX-1 genes are intensively associated with increased susceptibility to myocardial diseases. The splicing variant LOX IN dimerizes with the native form of LOX-1 and protects cells from damage by oxidized LDL. In the developing field of regenerating medicine, LOX-1 is a potential target for therapeutic intervention.
authors.affiliation: Department of Biochemistry, All India Institute of Medical Sciences , Patna 801507, India.
authors.forename: Bushra
authors.initials: B
authors.lastname: Zeya
authors.affiliation: Division of P&I, Indian Council of Medical Research , New Delhi 110 029, India.
authors.forename: Albina
authors.initials: A
authors.lastname: Arjuman
authors.affiliation: Department of Biochemistry, All India Institute of Medical Sciences , Patna 801507, India.
authors.forename: Nimai Chand
authors.initials: NC
authors.lastname: Chandra
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D008077:Lipoproteins, LDL / Q000378:metabolism*; D058990:Molecular Targeted Therapy; D051127:Scavenger Receptors, Class E / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D008077:Lipoproteins, LDL; D051127:Scavenger Receptors, Class E; C099252:oxidized low density lipoprotein