title: Joining Forces: Fermentation and Organic Synthesis for the Production of Complex Heterocycles.
abstract: Commercial application of many promising heterocyclic natural products is limited by their natural abundance. While organic synthesis provides access to many natural products, total synthesis of numerous complex molecules is not economically feasible. In recent years, the combination of fermentation and organic synthesis has provided a new route for the production of complex heterocycles that are inaccessible by typical synthetic methods. This JOCSynopsis will review examples of how this union of disciplines has overcome obstacles in both academia and industry.
authors.affiliation: Department of Chemistry, University of Pennsylvania , Philadelphia, Pennsylvania 19104, United States.
authors.forename: Claire M
authors.initials: CM
authors.lastname: Gober
authors.affiliation: Department of Chemistry, University of Pennsylvania , Philadelphia, Pennsylvania 19104, United States.
authors.forename: Madeleine M
authors.initials: MM
authors.lastname: Joullié
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis / Q000378:metabolism; D005285:Fermentation; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D009930:Organic Chemicals / Q000138:chemical synthesis*
chemical_list: D001688:Biological Products; D006571:Heterocyclic Compounds; D009930:Organic Chemicals