title: The interleukin-6-hepcidin-hemoglobin circuit in systemic lupus erythematosus flares.
abstract: Objective Hepcidin regulates iron availability and may be responsible for the anemia of chronic disease because it is induced by interleukin-6. This study investigated the IL-6-hepcidin-hemoglobin axis in patients with lupus. Methods IL-6 and hepcidin were measured in serial serum samples collected before, during and after lupus flares by specific ELISAs. Results During renal and non-renal SLE flare cycles IL-6 did not predict hepcidin and hepcidin did not predict hemoglobin. When lupus nephritis patients were in remission, IL-6 and hepcidin were correlated, but hepcidin and hemoglobin were not. Conclusion Hepcidin does not contribute significantly to anemia during active lupus.
authors.affiliation: 1 Department of Medicine, Ohio State University Wexner Medical Center and Department of Biostatistics, Ohio State University College of Public Health, USA.
authors.forename: D L
authors.initials: DL
authors.lastname: Indrakanti
authors.affiliation: 1 Department of Medicine, Ohio State University Wexner Medical Center and Department of Biostatistics, Ohio State University College of Public Health, USA.
authors.forename: A
authors.initials: A
authors.lastname: Alvarado
authors.affiliation: 1 Department of Medicine, Ohio State University Wexner Medical Center and Department of Biostatistics, Ohio State University College of Public Health, USA.
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.affiliation: 1 Department of Medicine, Ohio State University Wexner Medical Center and Department of Biostatistics, Ohio State University College of Public Health, USA.
authors.forename: D J
authors.initials: DJ
authors.lastname: Birmingham
authors.affiliation: 2 Department of biostatistics, Ohio State University Wexner Medical Center and Department of Biostatistics, Ohio State University College of Public Health, USA.
authors.forename: A
authors.initials: A
authors.lastname: Hinton
authors.affiliation: 1 Department of Medicine, Ohio State University Wexner Medical Center and Department of Biostatistics, Ohio State University College of Public Health, USA.
authors.forename: B H
authors.initials: BH
authors.lastname: Rovin
mesh_terms: D000740:Anemia / Q000097:blood / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006454:Hemoglobins / Q000378:metabolism*; D064451:Hepcidins / Q000097:blood*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000175:diagnosis; D008181:Lupus Nephritis / Q000097:blood* / Q000175:diagnosis; D008297:Male; D009820:Ohio; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D015415:Biomarkers; D006454:Hemoglobins; D064451:Hepcidins; C508600:IL6 protein, human; D015850:Interleukin-6
keywords: Hepcidin; anemia; inflammation; lupus nephritis