title: Safety of Secretin Administration in Children.
abstract: The aim of this study was to compare the hemodynamic parameters from the anesthesia records of children who underwent upper gastrointestinal endoscopy (esophagogastroduodenoscopy [EGD]) with and without secretin pancreatic function tests (sPFTs).
  
  
  
  The hemodynamic parameters were retrieved from an electronic anesthesia database. The secretin group consisted of 186 children, and the age- and sex-matched control group included 136 patients who did not have sPFTs.
  
  
  
  There was no difference in the demographic parameters (age and sex) between the 2 groups. The secretin group had a lower height and body mass index. The sPFT resulted in an average 3-minute extension of the endoscopic procedure. The heart rate increased during the EGD in both groups and was higher (averaged 7 beats per minute) in the secretin group than the EGD-only group. There were mild elevations on the systolic and diastolic blood pressures. None of these changes were clinically significant. There were no complications reported during the anesthesia and procedures in the 2 groups.
  
  
  
  Secretin PFT is a safe procedure. It only slightly prolongs the total procedure and anesthesia time. There were no clinically significant changes in the vital parameters in the secretin group, and there were no adverse effects recorded.
authors.affiliation: From the *Department of Pediatrics, Thomas Jefferson University, Philadelphia, PA; †Division of Gastroenterology and Nutrition, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE; ‡Center for Pediatric Digestive Health and Nutrition, Arnold Palmer Hospital for Children, Orlando, FL; §K. Hovnanian Children's Hospital, Jersey Shore University Hospital, Neptune, NJ; ∥Department of Anesthesia, Thomas Jefferson University, Philadelphia, PA; and ¶Departments of Anesthesia and Biomedical Research and #Gastroenterology Laboratory, Department of Biomedical Research, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE.
authors.forename: Karoly
authors.initials: K
authors.lastname: Horvath
authors.forename: Beth
authors.initials: B
authors.lastname: Loveridge-Lenza
authors.forename: B Randall
authors.initials: BR
authors.lastname: Brenn
authors.forename: J Fernando
authors.initials: JF
authors.lastname: Del Rosario
authors.forename: Zarela
authors.initials: Z
authors.lastname: Molle-Rios
authors.forename: Zhaoping
authors.initials: Z
authors.lastname: He
mesh_terms: D001794:Blood Pressure; D002648:Child; D004724:Endoscopy; D016145:Endoscopy, Digestive System; D006801:Humans; D010186:Pancreatic Function Tests; D012633:Secretin / Q000627:therapeutic use*
chemical_list: D012633:Secretin