title: Evaluation of cardiac risk marker levels in obese and non-obese patients with polycystic ovaries.
abstract: OBJECTIVE
  To compare cardiac risk markers such as asymmetric dimethyl arginine (ADMA), C-reactive protein (CRP), homocystein (Hcy), plasminogen activator inhibitor-1 (PAI-1), vascular endothelial growth factor (VEGF), angiopoietin-related growth factor 6 (ANGPTL6) in obese and non-obese patients with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Thirty obese (BMI >30 kg/m2) and 30 non-obese (BMI < 30 kg/m2) patients diagnosed with PCOS and 30 age-matched healthy controls were included in the study. The ages of subjects were varying between 18 and 30 years. Serum ADMA, CRP, Hcy, PAI-1, VEGF and ANGPTL6 levels were analyzed for each subject.
  
  
  RESULTS
  Serum ADMA, CRP, Hcy, PAI-1, VEGF and ANGPTL6 levels were significantly elevated in obese and non-obese women with PCOS in comparison to control subjects (p < 0.05). This elevation was more obvious in the obese PCOS group than in the other group.
  
  
  CONCLUSIONS
  Cardiovascular risk markers such as ADMA, CRP, Hcy, PAI-1, VEGF and ANGPTL6 levels are elevated in women with PCOS.
authors.affiliation: a Van Ipekyolu Maternity and Children's Disease Hospital, Clinic of Obstetrics and Gynecology , Van , Turkey.
authors.forename: Erkan
authors.initials: E
authors.lastname: Elci
authors.affiliation: b Bakirkoy Dr Sadi Konuk Training and Research Hospital Department of Obstetrics and Gynecology , Istanbul , Turkey , and.
authors.forename: Cihan
authors.initials: C
authors.lastname: Kaya
authors.affiliation: c Yüzüncü Yil University Faculty of Medicine Department of Obstetrics and Gynecology , Van , Turkey.
authors.forename: Numan
authors.initials: N
authors.lastname: Cim
authors.affiliation: c Yüzüncü Yil University Faculty of Medicine Department of Obstetrics and Gynecology , Van , Turkey.
authors.forename: Recep
authors.initials: R
authors.lastname: Yildizhan
authors.affiliation: c Yüzüncü Yil University Faculty of Medicine Department of Obstetrics and Gynecology , Van , Turkey.
authors.forename: Gulhan Gunes
authors.initials: GG
authors.lastname: Elci
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood* / Q000453:epidemiology; D005260:Female; D006801:Humans; D009765:Obesity / Q000097:blood* / Q000453:epidemiology; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000453:epidemiology; D012307:Risk Factors; D055815:Young Adult
chemical_list: D015415:Biomarkers
keywords: Angiopoietin-related growth factor; cardiovascular diagnostic technic; obesity; polycystic ovary syndrome