title: Comparison of the Performance of Two Different Spectral-Domain Optical Coherence Tomography Angiography Devices in Clinical Practice.
abstract: OBJECTIVE
  To compare the performance of two different spectral-domain optical coherence tomography angiography (OCTA) devices in clinical practice by evaluating examination execution time and the number of motion artifacts per image.
  
  
  METHODS
  Seventy-six patients affected by different ocular diseases and 13 healthy subjects consecutively underwent assessments by two different OCTA devices: AngioPlex (Zeiss Meditec, Inc., Dublin, Calif., USA) and AngioVue (OptoVue, Inc., Fremont, Calif., USA). Two different operators (L.A.D.V. and L.B.) measured execution times, excluded low-quality images, and counted the number of motion artifacts per image.
  
  
  RESULTS
  The mean execution time was shorter with AngioPlex than with AngioVue for all subjects (3 min 32 s ± 1 min 45 s vs. 4 min 35 s ± 1 min 11 s; p < 0.0001), for the healthy subjects (2 min 31 s ± 45 s vs. 4 min 1 s ± 53 s; p = 0.003), and for the patients (3 min 44 s ± 1 min 48 s vs. 4 min 42 s ± 1 min 13 s; p < 0.0001). The percentages of available images, low-signal-strength images, and images impossible to analyze of the total acquired images obtained using AngioPlex or AngioVue were 85, 6, and 9% and 56, 29, and 15%, respectively. The mean number of motion artifacts was significantly lower in images obtained using AngioPlex than in images obtained using AngioVue for all patients (6.5 ± 5.9 vs. 12.6 ± 8.5; p < 0.0001), for the healthy subjects (6.5 ± 4.6 vs. 10.9 ± 7.9; p = 0.0009), and for the patients (6.6 ± 6.3 vs. 13.1 ± 8.7; p < 0.0001). There was no correlation between the number of artifacts and execution time or patients' age.
  
  
  CONCLUSIONS
  AngioPlex and AngioVue are useful devices in clinical practice. AngioPlex requires a shorter execution time and provides a higher number of images available for analysis with fewer motion artifacts.
authors.affiliation: Department of Ophthalmology, Vita-Salute San Raffaele University, IRCCS Ospedale San Raffaele, Milan, Italy.
authors.forename: Luigi Antonio
authors.initials: LA
authors.lastname: De Vitis
authors.forename: Lucia
authors.initials: L
authors.lastname: Benatti
authors.forename: Livia
authors.initials: L
authors.lastname: Tomasso
authors.forename: Giovanni
authors.initials: G
authors.lastname: Baldin
authors.forename: Adriano
authors.initials: A
authors.lastname: Carnevali
authors.forename: Lea
authors.initials: L
authors.lastname: Querques
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Querques
authors.forename: Francesco
authors.initials: F
authors.lastname: Bandello
mesh_terms: D000328:Adult; D016477:Artifacts; D002829:Choroid / Q000098:blood supply*; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods*; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012164:Retinal Diseases / Q000175:diagnosis*; D012171:Retinal Vessels / Q000000981:diagnostic imaging*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*