title: Cell-Free Total and Fetal DNA in First Trimester Maternal Serum and Subsequent Development of Preeclampsia.
abstract: ObjectiveThe objective of this study was to assess the relationship between first trimester cell-free total and fetal DNA in maternal plasma and the subsequent development of preeclampsia.Study DesignNested case-control study of patients enrolled in the Combined Antioxidant and Preeclampsia Prediction Studies prediction study of 175 women who did and 175 women who did not develop preeclampsia. The predictive values of cell-free total and fetal DNA and the subsequent development of preeclampsia were measured using receiver operating characteristic curves.ResultsCell-free total DNA was higher in African American (median; 25-75%; 6.15; 0.14-28.73;p= 0.02) and Hispanic (4.95; 0.20-26.82;p= 0.037) compared with white women (2.33; 0.03-13.10). Levels of cell-free total DNA were also associated with maternal body mass index (BMI) (p= 0.02). Cell-free total DNA levels were similar between women who later developed preeclampsia (3.52; 0.11-25.3) and controls (3.74; 0.12-21.14,p= 0.96).ConclusionThere is no significant difference in levels of cell-free total DNA in the first trimester in women who subsequently develop preeclampsia. Levels of cell-free total DNA in the first trimester are increased in African American and Hispanic compared with white women, and levels increase with increasing BMI.
authors.affiliation: Eunice Kennedy Shriver National Institute of Child Health and Human Development, Maternal-Fetal Medicine Units Network, Bethesda, Maryland.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Silver
authors.affiliation: Eunice Kennedy Shriver National Institute of Child Health and Human Development, Maternal-Fetal Medicine Units Network, Bethesda, Maryland.
authors.forename: Leslie
authors.initials: L
authors.lastname: Myatt
authors.affiliation: Eunice Kennedy Shriver National Institute of Child Health and Human Development, Maternal-Fetal Medicine Units Network, Bethesda, Maryland.
authors.forename: John C
authors.initials: JC
authors.lastname: Hauth
authors.affiliation: Eunice Kennedy Shriver National Institute of Child Health and Human Development, Maternal-Fetal Medicine Units Network, Bethesda, Maryland.
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Leveno
authors.affiliation: Eunice Kennedy Shriver National Institute of Child Health and Human Development, Maternal-Fetal Medicine Units Network, Bethesda, Maryland.
authors.forename: Alan M
authors.initials: AM
authors.lastname: Peaceman
authors.affiliation: Eunice Kennedy Shriver National Institute of Child Health and Human Development, Maternal-Fetal Medicine Units Network, Bethesda, Maryland.
authors.forename: Susan M
authors.initials: SM
authors.lastname: Ramin
authors.affiliation: Eunice Kennedy Shriver National Institute of Child Health and Human Development, Maternal-Fetal Medicine Units Network, Bethesda, Maryland.
authors.forename: Philip
authors.initials: P
authors.lastname: Samuels
authors.affiliation: Eunice Kennedy Shriver National Institute of Child Health and Human Development, Maternal-Fetal Medicine Units Network, Bethesda, Maryland.
authors.forename: George
authors.initials: G
authors.lastname: Saade
authors.affiliation: Eunice Kennedy Shriver National Institute of Child Health and Human Development, Maternal-Fetal Medicine Units Network, Bethesda, Maryland.
authors.forename: Yoram
authors.initials: Y
authors.lastname: Sorokin
authors.affiliation: Eunice Kennedy Shriver National Institute of Child Health and Human Development, Maternal-Fetal Medicine Units Network, Bethesda, Maryland.
authors.forename: Rebecca G
authors.initials: RG
authors.lastname: Clifton
authors.affiliation: Eunice Kennedy Shriver National Institute of Child Health and Human Development, Maternal-Fetal Medicine Units Network, Bethesda, Maryland.
authors.forename: Uma M
authors.initials: UM
authors.lastname: Reddy
mesh_terms: D000293:Adolescent; D000328:Adult; D001741:Black or African American; D015992:Body Mass Index; D016022:Case-Control Studies; D000073888:Cell-Free Nucleic Acids / Q000097:blood*; D004247:DNA / Q000097:blood*; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood / Q000453:epidemiology*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood*; D012372:ROC Curve; D016032:Randomized Controlled Trials as Topic; D044465:White People; D055815:Young Adult
chemical_list: D000073888:Cell-Free Nucleic Acids; D004247:DNA