title: Current Clinical Practice: Current Management of Thrombotic Thrombocytopenic Purpura.
abstract: Historically, the mortality rate of thrombotic thrombocytopenic purpura (TTP) approached 100%. However, by the 1980's, new therapy was instituted with a vast improvement in survival to 90%. The exact pathogenesis of TTP remains elusive. Yet, despite incomplete understanding of the pathophysiology, outcome has improved due to increased awareness of the symptomatology leading to earlier diagnosis and better supportive care, in addition to effective therapy with plasma exchange. TTP represents a disease in which prompt diagnosis and treatment can lead to a critical difference in clinical outcome.
authors.affiliation: a Department of Internal Medicine, Division of Hematology/Oncology , Northwestern University School of Medicine, And VA Lakeside Medical Center , Chicago , IL.
authors.forename: J J
authors.initials: JJ
authors.lastname: Hong
authors.affiliation: a Department of Internal Medicine, Division of Hematology/Oncology , Northwestern University School of Medicine, And VA Lakeside Medical Center , Chicago , IL.
authors.forename: H C
authors.initials: HC
authors.lastname: Kwaan
keywords: Thrombotic thrombocytopenic purpura; cryosupernatant; fresh frozen plasma; plasma exchange; von Willebrand factor