title: In Vivo Magnetic Resonance Imaging and Microwave Thermotherapy of Cancer Using Novel Chitosan Microcapsules.
abstract: Herein, we develop a novel integrated strategy for the preparation of theranostic chitosan microcapsules by encapsulating ion liquids (ILs) and Fe3O4 nanoparticles. The as-prepared chitosan/Fe3O4@IL microcapsules exhibit not only significant heating efficacy in vitro under microwave (MW) irradiation but also obvious enhancement of T2-weighted magnetic resonance (MR) imaging, besides the excellent biocompatibility in physiological environments. The chitosan/Fe3O4@IL microcapsules show ideal temperature rise and therapeutic efficiency when applied to microwave thermal therapy in vivo. Complete tumor elimination is realizing after MW irradiation at an ultralow power density (1.8 W/cm(2)), while neither the MW group nor the chitosan microcapsule group has significant influence on the tumor development. The applicability of the chitosan/Fe3O4@IL microcapsules as an efficient contrast agent for MR imaging is proved in vivo. Moreover, the result of in vivo systematic toxicity shows that chitosan/Fe3O4@IL microcapsules have no acute fatal toxicity. Our study presents an interesting type of multifunctional platform developed by chitosan microcapsule promising for imaging-guided MW thermotherapy.
authors.affiliation: Department of Radiology, the First Hospital of China Medical University, No. 155 Nanjing North Road, Shenyang, 110001, People's Republic of China.|Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/Nanomaterials and Technology and Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.|College of Materials Science and Engineering, Sichuan University, Chengdu, 610065, China.
authors.forename: Shunsong
authors.initials: S
authors.lastname: Tang
authors.affiliation: Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/Nanomaterials and Technology and Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
authors.forename: Qijun
authors.initials: Q
authors.lastname: Du
authors.affiliation: Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/Nanomaterials and Technology and Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
authors.forename: Tianlong
authors.initials: T
authors.lastname: Liu
authors.affiliation: Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/Nanomaterials and Technology and Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
authors.forename: Longfei
authors.initials: L
authors.lastname: Tan
authors.affiliation: Department of Radiology, the First Hospital of China Medical University, No. 155 Nanjing North Road, Shenyang, 110001, People's Republic of China.
authors.forename: Meng
authors.initials: M
authors.lastname: Niu
authors.affiliation: Department of Radiology, the First Hospital of China Medical University, No. 155 Nanjing North Road, Shenyang, 110001, People's Republic of China.
authors.forename: Long
authors.initials: L
authors.lastname: Gao
authors.affiliation: College of Materials Science and Engineering, Sichuan University, Chengdu, 610065, China. zbhuang@scu.edu.cn.
authors.forename: Zhongbing
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/Nanomaterials and Technology and Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
authors.forename: Changhui
authors.initials: C
authors.lastname: Fu
authors.affiliation: Department of Radiology, the First Hospital of China Medical University, No. 155 Nanjing North Road, Shenyang, 110001, People's Republic of China.
authors.forename: Tengchuang
authors.initials: T
authors.lastname: Ma
authors.affiliation: Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/Nanomaterials and Technology and Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China. mengxw@mail.ipc.ac.cn.
authors.forename: Xianwei
authors.initials: X
authors.lastname: Meng
authors.affiliation: Department of Radiology, the First Hospital of China Medical University, No. 155 Nanjing North Road, Shenyang, 110001, People's Republic of China. haiboshao@aliyun.com.
authors.forename: Haibo
authors.initials: H
authors.lastname: Shao
keywords: Chitosan; Ionic liquids; MR imaging; Microcapsules; Microwave; Thermotherapy