title: Insights into the Mechanisms of the Acute Kidney Injury-to-Chronic Kidney Disease Continuum.
abstract: Acute kidney injury (AKI) is an increasingly common clinical problem with significant impact on long-term patient outcome. Recent clinical trials demonstrate that AKI is closely related to the progression of chronic kidney disease (CKD) and end-stage renal disease, though the precise mechanisms linking AKI to CKD remain unclear. While inflammation, microvascular rarefaction and hypoxia are involved in the AKI-to-CKD continuum, proximal tubule injury seems to play an important role in the progression of CKD. In this review, we focus on the mechanisms of the AKI-to-CKD continuum, especially the mechanism by which injury to the proximal tubules triggers progression to CKD. Elucidating the mechanisms involved in the AKI-to-CKD continuum will support the development of therapeutic options to prevent progression from AKI to CKD. © 2016 S. Karger AG, Basel.
authors.affiliation: Department of Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Takaori
authors.forename: Motoko
authors.initials: M
authors.lastname: Yanagita
mesh_terms: D058186:Acute Kidney Injury / Q000473:pathology*; D003266:Continuity of Patient Care; D006801:Humans; D051436:Renal Insufficiency, Chronic / Q000473:pathology*