title: Group 2 innate lymphoid cells are increased in nasal polyps in patients with eosinophilic chronic rhinosinusitis.
abstract: ILC2s represent a critical innate cellular source of type 2 cytokines and may play important roles in various diseases. We examined the role of ILC2s in the pathogenesis of two subgroups of CRSwNP: ECRS and non-ECRS. We analyzed the prevalence of ILC2s in sinonasal tissues and in blood from patients with ECRS, non-ECRS, CRSsNP, and control. The prevalence of ILC2s in nasal tissues was higher in patients with ECRS as compared to those with non-ECRS or CRSsNP. The prevalence of blood ILC2s was not different between patients with ECRS and non-ECRS. The prevalence of blood ILC2s was higher in patients with allergic rhinitis and elevated serum IgE levels. Alternaria-induced IL-33 secretion was increased in nasal epithelial cells derived from patients with ECRS as compared to those from patients with non-ECRS or CRSsNP. ILC2s may be involved in the pathogenesis of CRSwNP, in particular in patients with tissue eosinophilia (i.e., ECRS).
authors.affiliation: Department of Otorhinolaryngology, Shiga University of Medical Science, Otsu, Japan. Electronic address: itirotz@hotmail.com.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Tojima
authors.affiliation: Department of Otorhinolaryngology, Shiga University of Medical Science, Otsu, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kouzaki
authors.affiliation: Department of Otorhinolaryngology, Shiga University of Medical Science, Otsu, Japan.
authors.forename: Shino
authors.initials: S
authors.lastname: Shimizu
authors.affiliation: Department of Otorhinolaryngology, Shiga University of Medical Science, Otsu, Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Ogawa
authors.affiliation: Department of Otorhinolaryngology, Shiga University of Medical Science, Otsu, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Arikata
authors.affiliation: Division of Allergic Diseases, Department of Internal Medicine, and the Department of Immunology, Mayo Clinic, Rochester, MN, United States.
authors.forename: Hirohito
authors.initials: H
authors.lastname: Kita
authors.affiliation: Department of Otorhinolaryngology, Shiga University of Medical Science, Otsu, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Shimizu
mesh_terms: D000328:Adult; D000528:Alternaria / Q000737:chemistry / Q000276:immunology; D002478:Cells, Cultured; D002908:Chronic Disease; D016207:Cytokines / Q000276:immunology* / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D004804:Eosinophils / Q000276:immunology / Q000378:metabolism; D004847:Epithelial Cells / Q000276:immunology / Q000378:metabolism; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D000067596:Interleukin-33 / Q000276:immunology / Q000378:metabolism; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000276:immunology* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000276:immunology / Q000378:metabolism; D009298:Nasal Polyps / Q000097:blood / Q000276:immunology* / Q000378:metabolism; D012220:Rhinitis / Q000097:blood / Q000276:immunology* / Q000378:metabolism; D012852:Sinusitis / Q000097:blood / Q000276:immunology* / Q000378:metabolism
chemical_list: D016207:Cytokines; D000067596:Interleukin-33
keywords: Allergic rhinitis; Alternaria; Asthma; Eosinophilic chronic rhinosinusitis; Group 2 innate lymphoid cells; IL-33