title: Association of MBOAT7 gene variant with plasma ALT levels in children: the PANIC study.
abstract: We studied for the first time among children differences in plasma alanine aminotransferase (ALT) among genotypes of the rs641738 polymorphism in the MBOAT7 gene that has been associated with increased risk of nonalcoholic fatty liver disease among adults. We also investigated the associations of a genetic risk score combining information from the MBOAT7, PNPLA3, and TM6SF2 polymorphisms with plasma ALT.
  
  
  
  We performed a 2-y follow-up study in 467 Caucasian children aged 6-9 y, genotyped the MBOAT7, PNPLA3, and TM6SF2 polymorphisms, calculated a genetic risk score from these polymorphisms (scored 0-3) and assessed plasma ALT.
  
  
  
  Children carrying the T allele of the MBOAT7 polymorphism had 7% higher plasma ALT at baseline (17.8 vs. 19.1 U/l, P = 0.022) and 10% higher plasma ALT at 2-y follow-up (18.0 vs. 19.7 U/l, P = 0.022) than the noncarriers. A higher genetic risk score was associated with higher plasma ALT at baseline (17.5, 18.5, 19.2, and 22.8 U/l, P = 0.008 for linear trend) and 2-y follow-up (18.2, 18.9, 18.9, and 32.8 U/l, P = 0.017 for linear trend).
  
  
  
  Children carrying the T allele of the MBOAT7 polymorphism had higher plasma ALT than the noncarriers. Children with the MBOAT7, PNPLA3, and TM6SF2 variants had the highest plasma ALT.
authors.affiliation: Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland.
authors.forename: Anna
authors.initials: A
authors.lastname: Viitasalo
authors.affiliation: Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland.
authors.forename: Aino-Maija
authors.initials: AM
authors.lastname: Eloranta
authors.affiliation: Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Atalay
authors.affiliation: Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden.|Department of Medical and Surgical Sciences, Clinical Nutrition Unit, University Magna Graecia of Catanzaro, Catanzaro, Italy.|Cardiology Department, Sahlgrenska University Hospital, Gothenburg, Sweden.
authors.forename: Stefano
authors.initials: S
authors.lastname: Romeo
authors.affiliation: Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.|Clinical Nutrition and Obesity Center, Kuopio University Hospital, Kuopio, Finland.
authors.forename: Jussi
authors.initials: J
authors.lastname: Pihlajamäki
authors.affiliation: Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland.|Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland.|Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
authors.forename: Timo A
authors.initials: TA
authors.lastname: Lakka
mesh_terms: D000217:Acyltransferases / Q000235:genetics*; D000410:Alanine Transaminase / Q000097:blood*; D000483:Alleles; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008049:Lipase / Q000235:genetics; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D065626:Non-alcoholic Fatty Liver Disease / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D054512:Phospholipases A2, Calcium-Independent
chemical_list: D000217:Acyltransferases; D000410:Alanine Transaminase; D008049:Lipase; D008565:Membrane Proteins; C419195:TM6SF2 protein, human; C000616532:MBOAT7 protein, human; C533682:PNPLA3 protein, human; D054512:Phospholipases A2, Calcium-Independent