title: Experimental Medicine in Psychiatry New Approaches in Schizophrenia, Depression and Cognition.
abstract: The use of experimental medicine studies to bridge the gap between Phase 1 and 2 drug trials and so to enhance translation of basic neuroscience studies using experimental animals to the clinic is proposed. Illustrative examples are provided for affective disorders and schizophrenia in relation also to cognitive dysfunction.
authors.affiliation: P1vital LTD, Manor House, Howbery Park, Wallingford, Oxfordshire, OX10 8BA, UK. gdawson@p1vital.com.
authors.forename: Gerard R
authors.initials: GR
authors.lastname: Dawson
mesh_terms: D000818:Animals; D035843:Biomedical Research; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000503:physiopathology* / Q000523:psychology; D003866:Depressive Disorder / Q000503:physiopathology* / Q000523:psychology; D004195:Disease Models, Animal; D006801:Humans; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology
keywords: Clinical trials; Cognition; Depression; Experimental medicine; Schizotypy