title: Stereotactic Body Radiation Therapy for Stage I Non-Small Cell Lung Cancer.
abstract: Stereotactic body radiation therapy (SBRT) has had a profound impact on the treatment paradigm for medically inoperable patients with stage I non-small cell lung cancer. Local control and survival outcomes from prospective collaborative trials using SBRT have been highly favorable in this challenging patient population. Further study in medically operable patients is ongoing; however, randomized trials to help answer this question have terminated early because of poor accrual. Available prospective and retrospective data are discussed for the use of SBRT with regard to the medically inoperable and operable patient populations, as well as considerations for fractionation, dose, and toxicity.
authors.affiliation: Department of Radiation Oncology, SUNY Upstate Medical University, 750 E Adams Street, Syracuse, NY 13210, USA. Electronic address: aridgidp@upstate.edu.
authors.forename: Paul
authors.initials: P
authors.lastname: Aridgides
authors.affiliation: Department of Radiation Oncology, SUNY Upstate Medical University, 750 E Adams Street, Syracuse, NY 13210, USA.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Bogart
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis / Q000601:surgery*; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000601:surgery*; D009367:Neoplasm Staging; D016634:Radiosurgery / Q000379:methods*; D016896:Treatment Outcome
keywords: Medically inoperable; Medically operable; NSCLC; SBRT; Stage I non–small cell lung cancer; Stereotactic body radiation therapy