title: Synthesis of Didocosahexaenoylphosphatidylserine.
abstract: 1,2-Di-O-isopropylideneglycerophosphorochloridate prepared from isopropylindene glycerol and phosphorus oxychloride, was allowed to react with Z-l-serine-N-phthalimidomethyl ester to obtain a derivative of phosphatidylserine. Then, after the isopropylidene group was removed by Amberlite IR-120 (H(+)), and the phosphate group was also blocked as a Ba-salt, this derivative was coupled with docosahexaenoic acid, applying the method of activated ester. Removal of both protective groups of serine was finally done by dry hydrogen chloride in chloroform.
authors.affiliation: a Osaka Laboratory, Chemicals Inspection and Testing Institute , Japan, 1-6-5 Dogashiba, Tennouji-ku, Osaka 543 , Japan.
authors.forename: R
authors.initials: R
authors.lastname: Nakashima
authors.affiliation: a Osaka Laboratory, Chemicals Inspection and Testing Institute , Japan, 1-6-5 Dogashiba, Tennouji-ku, Osaka 543 , Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kado
authors.affiliation: a Osaka Laboratory, Chemicals Inspection and Testing Institute , Japan, 1-6-5 Dogashiba, Tennouji-ku, Osaka 543 , Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kume
authors.affiliation: a Osaka Laboratory, Chemicals Inspection and Testing Institute , Japan, 1-6-5 Dogashiba, Tennouji-ku, Osaka 543 , Japan.
authors.forename: K
authors.initials: K
authors.lastname: Maekawa
keywords: didocosahexaenoylphosphatidylserine; docosahexaenoic acid; phosphatidylserine