title: C-H Coupling Reactions Directed by Sulfoxides: Teaching an Old Functional Group New Tricks.
abstract: Sulfoxides are classical functional groups for directing the stoichiometric metalation and functionalization of C-H bonds. In recent times, sulfoxides have been given a new lease on life owing to the development of modern synthetic methods that have arisen because of their unique reactivity. They have recently been used in catalytic C-H activation proceeding via coordination of an internal sulfoxide to a metal or through the action of an external sulfoxide ligand. Furthermore, sulfoxides are able to capture nucleophiles and electrophiles to give sulfonium salts, which subsequently enable the formation of C-C bonds at the expense of C-H bonds. This Review summarizes a renaissance period in the application of sulfoxides arising from their versatility in directing C-H functionalization.
authors.affiliation: School of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK. alexander.pulis@manchester.ac.uk.
authors.forename: Alexander P
authors.identifier: 0000-0003-1754-527X
authors.initials: AP
authors.lastname: Pulis
authors.affiliation: School of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK. david.j.procter@manchester.ac.uk.
authors.forename: David J
authors.identifier: 0000-0003-3179-2509
authors.initials: DJ
authors.lastname: Procter
keywords: C−C coupling; C−H activation; S ligands; sulfonium; sulfoxide