title: Bioluminescent Probe for Detecting Mercury(II) in Living Mice.
abstract: A novel bioluminescence probe for mercury(II) was obtained on the basis of the distinct deprotection reaction of dithioacetal to decanal, so as to display suitable sensitivity and selectivity toward mercury(II) over other ions with bacterial bioluminescence signal. These experimental results indicated such a probe was a novel promising method for mercury(II) bioluminescence imaging in environmental and life sciences ex vivo and in vivo.
authors.affiliation: Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmaceutical Sciences, Shandong University , Jinan, Shandong 250012, China.
authors.forename: Tianyu
authors.initials: T
authors.lastname: Jiang
authors.affiliation: Laboratory of Anaesthesiology and Critical Care Medicine, Translational Neuroscience Center, West China Hospital, Sichuan University , Chengdu, Sichuan 610041, China.
authors.forename: Bowen
authors.initials: B
authors.lastname: Ke
authors.affiliation: Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmaceutical Sciences, Shandong University , Jinan, Shandong 250012, China.|Laboratory of Anaesthesiology and Critical Care Medicine, Translational Neuroscience Center, West China Hospital, Sichuan University , Chengdu, Sichuan 610041, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences , Beijing 100190, China.
authors.forename: Weishan
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmaceutical Sciences, Shandong University , Jinan, Shandong 250012, China.
authors.forename: Lupei
authors.initials: L
authors.lastname: Du
authors.affiliation: State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences , Beijing 100190, China.
authors.forename: Keqian
authors.initials: K
authors.lastname: Yang
authors.affiliation: Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmaceutical Sciences, Shandong University , Jinan, Shandong 250012, China.
authors.forename: Minyong
authors.initials: M
authors.lastname: Li
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000818:Animals; D004926:Escherichia coli / Q000201:enzymology; D008156:Luciferases / Q000737:chemistry; D049449:Luminescence; D049408:Luminescent Agents / Q000138:chemical synthesis / Q000737:chemistry*; D008163:Luminescent Measurements; D008628:Mercury / Q000097:blood* / Q000737:chemistry; D008819:Mice, Nude; D013438:Sulfhydryl Compounds / Q000737:chemistry
chemical_list: D000447:Aldehydes; D049408:Luminescent Agents; D013438:Sulfhydryl Compounds; C021170:decanaldehyde; D008156:Luciferases; D008628:Mercury; C007638:ethanethiol