title: Carrot juice ingestion attenuates high fructose-induced circulatory pro-inflammatory mediators in weanling Wistar rats.
abstract: BACKGROUND
  Adipose tissue, an endocrine organ, plays a vital role not only in energy homeostasis, but also in the development and/or progression of various metabolic diseases, such as insulin resistance, type 2 diabetes and non-alcoholic fatty liver disease (NAFLD), via several factors and mechanisms, including inflammation. This study tested, whether carrot juice administration affected the adipose tissue development and its inflammatory status in a high fructose diet-induced rat model. For this purpose, male weanling Wistar rats were divided into four groups and fed either control or high fructose diet of AIN-93G composition with or without carrot juice ingestion for an 8 week period.
  
  
  RESULTS
  Administration of carrot juice did not affect the adiposity and cell size of visceral fat depot; retroperitoneal white adipose tissue (RPWAT), which was corroborated with unaltered expression of genes involved in adipogenic and lipogenic pathways. However, it significantly reduced the high fructose diet-induced elevation of plasma free fatty acid (FFA) (P ≤ 0.05), macrophage chemoattractant protein 1 (MCP1) (P ≤ 0.01) and high sensitive C-reactive protein (hsCRP) (P ≤ 0.05) levels.
  
  
  CONCLUSIONS
  Carrot juice administration attenuated the high fructose diet-induced elevation of levels of circulatory FFA and pro-inflammatory mediators; MCP1 and hsCRP without affecting the adiposity and cell size of visceral fat depot; RPWAT. © 2016 Society of Chemical Industry.
authors.affiliation: Lipid Biochemistry Division, National Institute of Nutrition, Jamai Osmania, Hyderabad, 500007, India.
authors.forename: Malleswarapu
authors.initials: M
authors.lastname: Mahesh
authors.affiliation: Lipid Biochemistry Division, National Institute of Nutrition, Jamai Osmania, Hyderabad, 500007, India.
authors.forename: Munugala
authors.initials: M
authors.lastname: Bharathi
authors.affiliation: Lipid Biochemistry Division, National Institute of Nutrition, Jamai Osmania, Hyderabad, 500007, India.
authors.forename: Mooli
authors.initials: M
authors.lastname: Raja Gopal Reddy
authors.affiliation: Lipid Biochemistry Division, National Institute of Nutrition, Jamai Osmania, Hyderabad, 500007, India.
authors.forename: Pranati
authors.initials: P
authors.lastname: Pappu
authors.affiliation: Pathology  Division, National Institute of Nutrition, Jamai Osmania, Hyderabad, 500007, India.
authors.forename: Uday Kumar
authors.initials: UK
authors.lastname: Putcha
authors.affiliation: Lipid Biochemistry Division, National Institute of Nutrition, Jamai Osmania, Hyderabad, 500007, India.
authors.forename: Ayyalasomayajula
authors.initials: A
authors.lastname: Vajreswari
authors.affiliation: Lipid Biochemistry Division, National Institute of Nutrition, Jamai Osmania, Hyderabad, 500007, India.
authors.forename: Shanmugam M
authors.initials: SM
authors.lastname: Jeyakumar
mesh_terms: D050154:Adiposity / Q000187:drug effects; D000818:Animals; D002097:C-Reactive Protein / Q000187:drug effects; D002630:Chemotactic Factors / Q000009:adverse effects; D018552:Daucus carota; D004032:Diet; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005632:Fructose / Q000009:adverse effects*; D000067030:Fruit and Vegetable Juices; D018836:Inflammation Mediators / Q000009:adverse effects; D050152:Intra-Abdominal Fat / Q000166:cytology / Q000187:drug effects; D008297:Male; D017208:Rats, Wistar
chemical_list: D002630:Chemotactic Factors; D005230:Fatty Acids, Nonesterified; D018836:Inflammation Mediators; D005632:Fructose; D002097:C-Reactive Protein
keywords: adipose; inflammation; juice; steatosis; vegetables