title: Impact of an endorectal coil for 1H-magnetic resonance spectroscopy of the prostate at 3.0T in comparison to 1.5T: Do we need an endorectal coil?
abstract: OBJECTIVE
  To evaluate the influence of endorectal coil (ERC) regarding spectral quality and diagnostic suitability and diagnostic performance in 3.0T 1H-magnetic resonance spectroscopy imaging (MRSI) compared to 1.5T MRSI.
  
  
  METHODS
  The study was approved by the Institutional Review Board. MRSI of the prostate was performed on 19 patients at 1.5T with ERC (protocol 1), at 3.0T with a disabled ERC (protocol 2) and at 3.0T with ERC (protocol 3). Age, weight, body size, body-mass-index, prostate volume, time between measurements, diagnostic suitability of spectra, histopathological results after biopsy of cancer suspect lesions (CSL), sensitivity and specificity were evaluated. Signal-to-noise ratio (SNR) was calculated and compared using semiparametrical multiple Conover-comparisons. Correlations between SNR and prostate volume and BMI were indicated using Pearson correlation coefficient. Distribution of SNR was evaluated for prostate quadrants.
  
  
  RESULTS
  Diagnostic suitable spectra were achieved in 76 % (protocol 1, 100% in CSL), 32 % (protocol 2, 59% in CSL) and 50 % (protocol 3, 80% in CSL) of the voxels. SNR was significantly higher in protocol 3 compared to protocol 2 and 1 (93,729 vs. 27,836 vs. 32,897, p<0.0001) with significant difference between protocol 2 and 1 (p<0.023). Highest SNR was achieved in the dorsal prostate (protocols 1 and 3; p<0.0001). Sensitivity at 3.0T was higher with use of ERC. Specificity was highest at 1.5T with ERC.
  
  
  CONCLUSIONS
  The ERC improves the diagnostic suitability and the SNR in MRSI at 3.0T. Less voxels at 3.0T with disabled ERC are suitable for diagnosis compared to 1.5T with ERC. MRSI at 3.0T with ERC shows the highest SNR. SNR in dorsal quadrants of the prostate was higher using ERC.
authors.affiliation: Department of Diagnostic and Interventional Radiology, Goethe University of Frankfurt, Theodor-Stern-Kai 7, Haus 23c, 60590 Frankfurt am Main, Hesse, Germany. Electronic address: Maximilian.Hoffner@gmx.net.
authors.forename: Maximilian K M
authors.initials: MK
authors.lastname: Hoffner
authors.affiliation: Department of Diagnostic and Interventional Radiology, Goethe University of Frankfurt, Theodor-Stern-Kai 7, Haus 23c, 60590 Frankfurt am Main, Hesse, Germany. Electronic address: Frank.Huebner@kgu.de.
authors.forename: Frank
authors.initials: F
authors.lastname: Huebner
authors.affiliation: Department of Diagnostic and Interventional Radiology, Goethe University of Frankfurt, Theodor-Stern-Kai 7, Haus 23c, 60590 Frankfurt am Main, Hesse, Germany. Electronic address: Janerikscholtz@gmail.com.
authors.forename: Jan Erik
authors.initials: JE
authors.lastname: Scholtz
authors.affiliation: Department of Diagnostic and Interventional Radiology, Goethe University of Frankfurt, Theodor-Stern-Kai 7, Haus 23c, 60590 Frankfurt am Main, Hesse, Germany. Electronic address: Zangos@em.uni-frankfurt.de.
authors.forename: Stephan
authors.initials: S
authors.lastname: Zangos
authors.affiliation: Department of Diagnostic and Interventional Radiology, Goethe University of Frankfurt, Theodor-Stern-Kai 7, Haus 23c, 60590 Frankfurt am Main, Hesse, Germany. Electronic address: Boris.Schell@googlemail.com.
authors.forename: Boris
authors.initials: B
authors.lastname: Schulz
authors.affiliation: Department of Diagnostic and Interventional Radiology, Goethe University of Frankfurt, Theodor-Stern-Kai 7, Haus 23c, 60590 Frankfurt am Main, Hesse, Germany. Electronic address: luboldt@screening.org.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Luboldt
authors.affiliation: Department of Diagnostic and Interventional Radiology, Goethe University of Frankfurt, Theodor-Stern-Kai 7, Haus 23c, 60590 Frankfurt am Main, Hesse, Germany. Electronic address: t.vogl@em.uni-frankfurt.de.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Vogl
authors.affiliation: Department of Diagnostic and Interventional Radiology, Goethe University of Frankfurt, Theodor-Stern-Kai 7, Haus 23c, 60590 Frankfurt am Main, Hesse, Germany. Electronic address: bbodelle@googlemail.com.
authors.forename: Boris
authors.initials: B
authors.lastname: Bodelle
mesh_terms: D000368:Aged; D001706:Biopsy; D015992:Body Mass Index; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation* / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000295:instrumentation* / Q000379:methods; D007091:Image Processing, Computer-Assisted / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011467:Prostate / Q000000981:diagnostic imaging / Q000473:pathology; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D012680:Sensitivity and Specificity; D059629:Signal-To-Noise Ratio
keywords: 3.0T MRSI; Diagnostic suitability; Endorectal coil; Prostate; Proton MR Spectroscopic Imaging; Signal-to-noise ratio