title: [Obesity, a risk factor for ascending bacterial infection during pregnancy].
abstract: BACKGROUND
  Obesity in pregnancy is associated with significantly higher rates of infection.
  
  
  OBJECTIVE
  To compare the infectious morbidity in pregnant women with normal and altered body mass index (BMI).
  
  
  METHODS
  Cross sectional retrospective study of 6,150 patients who had delivery or second trimester abortion during 2012. The patients were classified according to BMI as underweight, normal weight, overweight and obese. We compared the frequency of pregnancy and perinatal complications related to ascending bacterial infection (ABI). The data was obtained from the hospitals databases.
  
  
  RESULTS
  Obese patients had higher rates of pregnancy and perinatal complications related to ABI compared to patients with normal weight. The odds ratios (OR) and 95% confidence intervals (CI) for second trimester abortion were 3.45 (1.63-7.31) p < 0.01, for preterm delivery 2.42 (1.51-3.87) p < 0.01, for labor and puerperium infections 3.42 (2.06-5.68) p < 0.01 and for early neonatal infectious and perinatal mortality 4.46 (1.75-11.37) p < 0.01. A logistic regression analysis revealed that obesity is an independent risk factor for second trimester abortion related to ABI with an OR of 3.18 (CI 95% 1.46-6.91), premature delivery related to ABI with an OR of 2.51 (CI 95% 1.54-4.09) and for delivery and postpartum infections with an OR of 4.44 (CI 95% 2.62 to 7.51).
  
  
  CONCLUSIONS
  Obese pregnant women had a 2.5 to 4.5 times increased risk of infectious morbidity compared to normal weight patients. Obesity is an independent risk factor for second trimester abortion and preterm delivery related to ABI and delivery and postpartum infectious.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Ovalle
authors.forename: María Angélica
authors.initials: MA
authors.lastname: Martínez
authors.forename: Ariel
authors.initials: A
authors.lastname: Fuentes
authors.forename: Ximena
authors.initials: X
authors.lastname: Marques
authors.forename: Francisco
authors.initials: F
authors.lastname: Vargas
authors.forename: Paula
authors.initials: P
authors.lastname: Vergara
authors.forename: Pablo
authors.initials: P
authors.lastname: Staig
authors.forename: María Paz
authors.initials: MP
authors.lastname: Marín
authors.forename: Francisco
authors.initials: F
authors.lastname: Oda
authors.forename: Elena
authors.initials: E
authors.lastname: Kakarieka
mesh_terms: D000293:Adolescent; D000328:Adult; D001424:Bacterial Infections / Q000453:epidemiology / Q000209:etiology*; D015992:Body Mass Index; D002648:Child; D002677:Chile / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007226:Infant Mortality; D016015:Logistic Models; D008875:Middle Aged; D009017:Morbidity; D009765:Obesity / Q000150:complications* / Q000453:epidemiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology / Q000382:microbiology*; D011256:Pregnancy Outcome; D047928:Premature Birth; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult