title: Cataracts after Low-Dose Radiotherapy for Lymphoproliferative Disease of the Ocular Adnexa.
abstract: OBJECTIVE
  To investigate the interval between low-dose radiotherapy and radiation-induced cataracts, and the factors affecting this interval, in patients with lymphoproliferative disease of the ocular adnexa.
  
  
  METHODS
  A retrospective case series of 73 eyes of 59 patients who underwent radiotherapy from 1996 to 2005 with total doses ranging from 24 to 30 Gy was conducted. We investigated the relationships between the radiation-associated cataract formation intervals and age, gender, diabetes, and the use of corticosteroids.
  
  
  RESULTS
  The mean interval was 36 months. None of the patients with lens shield developed cataracts. Age was inversely and significantly and gender was not significantly associated with the interval from first radiotherapy to cataract occurrence. The intervals did not differ significantly according to the presence of diabetes and corticosteroid therapy.
  
  
  CONCLUSIONS
  The mean interval from the start of radiation therapy to radiation-related cataract formation was 36 months and age was a significant factor affecting this interval.
authors.affiliation: a Graduate School of Medical Sciences , Kyushu University , Fukuoka , Japan.
authors.forename: Sawako
authors.identifier: http://orcid.org/0000-0002-0012-3209
authors.initials: S
authors.lastname: Hashimoto
authors.affiliation: a Graduate School of Medical Sciences , Kyushu University , Fukuoka , Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yoshikawa
authors.affiliation: a Graduate School of Medical Sciences , Kyushu University , Fukuoka , Japan.
authors.forename: Michiko
authors.initials: M
authors.lastname: Miyagi
authors.affiliation: a Graduate School of Medical Sciences , Kyushu University , Fukuoka , Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Onishi
authors.affiliation: a Graduate School of Medical Sciences , Kyushu University , Fukuoka , Japan.
authors.forename: Saiji
authors.initials: S
authors.lastname: Ohga
authors.affiliation: a Graduate School of Medical Sciences , Kyushu University , Fukuoka , Japan.
authors.forename: Kaori
authors.initials: K
authors.lastname: Asai
authors.affiliation: a Graduate School of Medical Sciences , Kyushu University , Fukuoka , Japan.
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Ishibashi
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002386:Cataract / Q000209:etiology*; D048909:Diabetes Complications; D005134:Eye Neoplasms / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D011832:Radiation Injuries / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects*; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones
keywords: Disease of the ocular adnexa; factors associated with cataracts; lens shielding; low-dose radiotherapy; lymphoproliferative; radiation-related cataract