title: Genetic evidence for natural selection in humans in the contemporary United States.
abstract: Recent findings from molecular genetics now make it possible to test directly for natural selection by analyzing whether genetic variants associated with various phenotypes have been under selection. I leverage these findings to construct polygenic scores that use individuals' genotypes to predict their body mass index, educational attainment (EA), glucose concentration, height, schizophrenia, total cholesterol, and (in females) age at menarche. I then examine associations between these scores and fitness to test whether natural selection has been occurring. My study sample includes individuals of European ancestry born between 1931 and 1953 who participated in the Health and Retirement Study, a representative study of the US population. My results imply that natural selection has been slowly favoring lower EA in both females and males, and are suggestive that natural selection may have favored a higher age at menarche in females. For EA, my estimates imply a rate of selection of about -1.5 mo of education per generation (which pales in comparison with the increases in EA observed in contemporary times). Although they cannot be projected over more than one generation, my results provide additional evidence that humans are still evolving-albeit slowly, especially compared with the rapid changes that have occurred over the past few generations due to cultural and environmental factors.
authors.affiliation: Department of Economics, Harvard University, Cambridge, MA 02138 jonathan.pierre.beauchamp@gmail.com.
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: Beauchamp
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000235:genetics; D001827:Body Height / Q000235:genetics; D015992:Body Mass Index; D002784:Cholesterol / Q000235:genetics; D004522:Educational Status; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008572:Menarche / Q000235:genetics; D008875:Middle Aged; D008957:Models, Genetic; D010641:Phenotype; D012559:Schizophrenia / Q000235:genetics; D012641:Selection, Genetic
chemical_list: D001786:Blood Glucose; D002784:Cholesterol
keywords: educational attainment; human evolution; menarche; natural selection; polygenic scores