title: Comparing the Efficacy of 7%, 3% and 0.9% Saline in Moderate to Severe Bronchiolitis in Infants.
abstract: BACKGROUND
  There is no standard treatment option in acute bronchiolitis. 3-7% hypertonic saline (HS) seems to be the effective treatment choice for reducing the hospitalization day.
  
  
  OBJECTIVE
  To compare the effect of nebulized 7% HS/salbutamol and 3% HS/salbutamol to 0.9% saline/salbutamol. The primary outcome measure was the effect of study drugs on the length of hospital stay (LOS). Secondary outcome measures were safety and efficacy in reducing the clinical severity score (CSS) at the 24 hours of the study.
  
  
  METHODS
  Prospective, double-blinded randomized clinical study.
  
  
  METHODS
  The study consists of 104 infants. Groups were constituted according to the treatment they received: These are, group A - 0.9% saline/salbutamol, group B -3% HS/salbutamol and group C-7% HS/salbutamol. Heart beat, Bronchiolitis CSS and oxygen saturation of the patients were determined before and after nebulization. The patients were monitored for adverse reactions.
  
  
  RESULTS
  Length of hospital stay in group A, B and C were as follows; 72.0 (20-288) hours in group A, 64.0 (12-168) hours in group B and 60.0 (12-264) hours in group C. No significant differences was observed among three groups (p>0.05).
  
  
  CONCLUSIONS
  7% HS and 3% HS does not have any effect to decrease LOS for infants with bronchiolitis.
authors.affiliation: Department of Pediatrics, Kayseri Training and Research Hospital, Kayseri, Turkey.
authors.forename: Seçil
authors.initials: S
authors.lastname: Köse
authors.affiliation: Department of Pediatrics, Kayseri Training and Research Hospital, Kayseri, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Şehriyaroğlu
authors.affiliation: Department of Pediatrics, Kayseri Training and Research Hospital, Kayseri, Turkey.
authors.forename: Feyza
authors.initials: F
authors.lastname: Esen
authors.affiliation: Department of Pediatrics, Kayseri Training and Research Hospital, Kayseri, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Özdemir
authors.affiliation: Department of Pediatrics, Kayseri Training and Research Hospital, Kayseri, Turkey.
authors.forename: Zehra
authors.initials: Z
authors.lastname: Kardaş
authors.affiliation: Department of Pediatrics, Kayseri Training and Research Hospital, Kayseri, Turkey.
authors.forename: Umut
authors.initials: U
authors.lastname: Altuğ
authors.affiliation: Department of Pediatrics, Kayseri Training and Research Hospital, Kayseri, Turkey.
authors.forename: Esef
authors.initials: E
authors.lastname: Karakuş
authors.affiliation: Department of Pediatrics, Kayseri Training and Research Hospital, Kayseri, Turkey.
authors.forename: Alper
authors.initials: A
authors.lastname: Özcan
authors.affiliation: Department of Pediatrics, Kayseri Training and Research Hospital, Kayseri, Turkey.
authors.forename: Ali Fatih
authors.initials: AF
authors.lastname: Kısaarslan
authors.affiliation: Departments of Biostatistics and Bioinformatics, Erciyes University School of Medicine, Kayseri, Turkey.
authors.forename: Ferhan
authors.initials: F
authors.lastname: Elmalı
authors.affiliation: Department of Pediatrics, Kayseri Training and Research Hospital, Kayseri, Turkey.
authors.forename: Yasemin Altuner
authors.initials: YA
authors.lastname: Torun
authors.affiliation: Department of Pediatrics, Division of Pediatric Pulmonology Unit, Erciyes University School of Medicine, Kayseri, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Köse
keywords: Bronchiolitis; hypertonic saline; infant