title: Embutramide, a Component of Tanax(®) (T-61) as a New Drug of Abuse?
abstract: Tanax(®) (T-61) is a euthanasia solution commonly used in veterinary medicine in Europe. It consists of three active components: embutramide, mebezonium iodide, and tetracaine hydrochloride. Human consumption of Tanax(®) (T-61) is usually associated with suicide attempts. In our 15-year-long practice, embutramide was detected only three times but within a short period. First, it was found in the urine of a 42-year-old veterinarian, and the other two observations were made in a 16-year-old young man. Urine samples were analyzed using Shimadzu Prominence TOX.I.S.II. HPLC-DAD system with online SPE extraction system. Both of the two patients denied any intention to die. These cases show that this veterinary drug may also be considered as potential drugs of abuse.
authors.affiliation: Department of Laboratory Medicine, Medical School, University of Pécs, Ifjúság str. 13., Pécs, H-7624, Hungary.
authors.forename: Anikó
authors.initials: A
authors.lastname: Lajtai
authors.affiliation: Institute of Forensic Medicine, Medical School, University of Pécs, Szigeti str. 12., Pécs, H-7624, Hungary.
authors.forename: Mátyás
authors.initials: M
authors.lastname: Mayer
authors.affiliation: Department of Laboratory Medicine, Medical School, University of Pécs, Ifjúság str. 13., Pécs, H-7624, Hungary.
authors.forename: Ágnes
authors.initials: Á
authors.lastname: Lakatos
authors.affiliation: Institute of Forensic Medicine, Medical School, University of Pécs, Szigeti str. 12., Pécs, H-7624, Hungary.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Porpáczy
authors.affiliation: Department of Laboratory Medicine, Medical School, University of Pécs, Ifjúság str. 13., Pécs, H-7624, Hungary.
authors.forename: Attila
authors.initials: A
authors.lastname: Miseta
mesh_terms: D000293:Adolescent; D000328:Adult; D000525:Alprazolam / Q000652:urine; D000577:Amides / Q000009:adverse effects* / Q000652:urine*; D004338:Drug Combinations; D006801:Humans; D008297:Male; D010208:Papaverine / Q000031:analogs & derivatives / Q000652:urine; D000644:Quaternary Ammonium Compounds / Q000009:adverse effects*; D019966:Substance-Related Disorders / Q000652:urine*; D013748:Tetracaine / Q000009:adverse effects*
chemical_list: D000577:Amides; D004338:Drug Combinations; D000644:Quaternary Ammonium Compounds; D013748:Tetracaine; C059324:embutramide; C015591:T 61; C005317:drotaverin; D010208:Papaverine; D000525:Alprazolam
keywords: Tanax®(T-61); clinical toxicology; drugs of abuse; embutramide; forensic science; forensic toxicology