title: Community Willingness to Participate in a Dengue Study in Aceh Province, Indonesia.
abstract: BACKGROUND
  Dengue virus infection is the most rapidly spreading vector-borne disease in the world. Essential research on dengue virus transmission and its prevention requires community participation. Therefore, it is crucial to understand the factors that are associated with the willingness of communities in high prevalence areas to participate in dengue research. The aim of this study was to explore factors associated with the willingness of healthy community members in Aceh province, Indonesia, to participate in dengue research that would require phlebotomy.
  
  
  RESULTS
  A community-based cross-sectional study was carried out in nine regencies and municipalities of Aceh from November 2014 to March 2015. Interviews using a set of validated questionnaires were conducted to collect data on demography, history of dengue infection, socioeconomic status, and knowledge, attitude and practice regarding dengue fever. Two-step logistic regression and Spearman's rank correlation (rs) analysis were used to assess the influence of independent variables on dependent variables. Among 535 participants, less than 20% had a good willingness to participate in the dengue study. The factors associated with good willingness to participate were being female, working as a civil servant, private employee or entrepreneur, having a high socioeconomic status and good knowledge, attitude and practice regarding dengue. Good knowledge and attitude regarding dengue were positive independent predictors of willingness to participate (OR: 2.30 [95% CI: 1.36-3.90] and 3.73 [95% CI: 2.24-6.21], respectively).
  
  
  CONCLUSIONS
  The willingness to participate in dengue research is very low among community members in Aceh, and the two most important associated factors are knowledge and attitude regarding dengue. To increase participation rate, efforts to improve the knowledge and attitude of community members regarding dengue fever and dengue-related research is required before such studies are launched.
authors.affiliation: Medical Research Unit, School of Medicine, Syiah Kuala University, Banda Aceh, Indonesia.|Tropical Disease Centre, School of Medicine, Syiah Kuala University, Banda Aceh, Indonesia.|Department of Microbiology, School of Medicine, Syiah Kuala University, Banda Aceh, Indonesia.|School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Western Australia, Australia.
authors.forename: Harapan
authors.identifier: http://orcid.org/0000-0001-7630-8413
authors.initials: H
authors.lastname: Harapan
authors.affiliation: Department of Statistics, Faculty of Mathematics and Natural Sciences, Syiah Kuala University, Banda Aceh, Indonesia.
authors.forename: Samsul
authors.initials: S
authors.lastname: Anwar
authors.affiliation: Department of Biology, Faculty of Teacher Training and Education, Syiah Kuala University, Banda Aceh, Indonesia.
authors.forename: Aslam
authors.initials: A
authors.lastname: Bustaman
authors.affiliation: Medical Research Unit, School of Medicine, Syiah Kuala University, Banda Aceh, Indonesia.
authors.forename: Arsil
authors.initials: A
authors.lastname: Radiansyah
authors.affiliation: Medical Research Unit, School of Medicine, Syiah Kuala University, Banda Aceh, Indonesia.
authors.forename: Pradiba
authors.initials: P
authors.lastname: Angraini
authors.affiliation: Medical Research Unit, School of Medicine, Syiah Kuala University, Banda Aceh, Indonesia.
authors.forename: Riny
authors.initials: R
authors.lastname: Fasli
authors.affiliation: Medical Research Unit, School of Medicine, Syiah Kuala University, Banda Aceh, Indonesia.
authors.forename: Salwiyadi
authors.initials: S
authors.lastname: Salwiyadi
authors.affiliation: Medical Research Unit, School of Medicine, Syiah Kuala University, Banda Aceh, Indonesia.
authors.forename: Reza Akbar
authors.initials: RA
authors.lastname: Bastian
authors.affiliation: Medical Research Unit, School of Medicine, Syiah Kuala University, Banda Aceh, Indonesia.
authors.forename: Ade
authors.initials: A
authors.lastname: Oktiviyari
authors.affiliation: Medical Research Unit, School of Medicine, Syiah Kuala University, Banda Aceh, Indonesia.
authors.forename: Imaduddin
authors.initials: I
authors.lastname: Akmal
authors.affiliation: Medical Research Unit, School of Medicine, Syiah Kuala University, Banda Aceh, Indonesia.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Iqbalamin
authors.affiliation: Medical Research Unit, School of Medicine, Syiah Kuala University, Banda Aceh, Indonesia.
authors.forename: Jamalul
authors.initials: J
authors.lastname: Adil
authors.affiliation: Medical Research Unit, School of Medicine, Syiah Kuala University, Banda Aceh, Indonesia.
authors.forename: Fenni
authors.initials: F
authors.lastname: Henrizal
authors.affiliation: Medical Research Unit, School of Medicine, Syiah Kuala University, Banda Aceh, Indonesia.
authors.forename: Darmayanti
authors.initials: D
authors.lastname: Darmayanti
authors.affiliation: Medical Research Unit, School of Medicine, Syiah Kuala University, Banda Aceh, Indonesia.
authors.forename: Rovy
authors.initials: R
authors.lastname: Pratama
authors.affiliation: Medical Research Unit, School of Medicine, Syiah Kuala University, Banda Aceh, Indonesia.
authors.forename: Jonny Karunia
authors.initials: JK
authors.lastname: Fajar
authors.affiliation: Department of Microbiology, Faculty of Medicine and Health Sciences, State Islamic University Maulana Malik Ibrahim, Malang, Indonesia.
authors.forename: Abdul Malik
authors.initials: AM
authors.lastname: Setiawan
authors.affiliation: School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Western Australia, Australia.
authors.forename: Allison
authors.initials: A
authors.lastname: Imrie
authors.affiliation: Institute of Occupational Medicine, Social Medicine and Environmental Medicine, Goethe University, Frankfurt am Main, Germany.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Kuch
authors.affiliation: Institute of Occupational Medicine, Social Medicine and Environmental Medicine, Goethe University, Frankfurt am Main, Germany.
authors.forename: David Alexander
authors.initials: DA
authors.lastname: Groneberg
authors.affiliation: Eijkman Institute for Molecular Biology, Jakarta, Indonesia.
authors.forename: R Tedjo
authors.initials: RT
authors.lastname: Sasmono
authors.affiliation: Nepal Health Research Council (NHRC), Ministry of Health Complex, Kathmandu, Nepal.
authors.forename: Meghnath
authors.initials: M
authors.lastname: Dhimal
authors.affiliation: Institute of Occupational Medicine, Social Medicine and Environmental Medicine, Goethe University, Frankfurt am Main, Germany.
authors.forename: Ruth
authors.initials: R
authors.lastname: Müller
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003256:Community Participation / Q000523:psychology*; D003715:Dengue / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007214:Indonesia / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011795:Surveys and Questionnaires; D055815:Young Adult