title: [NO and cancer: itinerary of a double agent].
abstract: Protein S-nitrosylation is now recognized as a ubiquitous regulatory mechanism. Like any post-translational modifications, S-nitrosylation is critical for the control of numerous cellular processes. It is now clear that S-nitrosylation is playing a double game, enhancing or inhibiting the tumor growth or the induction of cell death. Thanks to research aimed at demonstrating NO cytotoxic effects, new therapeutic strategies based on NO donor drugs have emerged. Although therapeutic NO donors can target a large number of proteins, the cellular mechanism is still not fully understood. This review reflects the current state of knowledge on S-nitrosylated proteins that take part of the oncogenic and apoptotic signaling, putting forward proteins with potential interest in cancer therapy.
authors.affiliation: Université de Bourgogne Franche-Comté, LIIC EA7269, 7, boulevard Jeanne d'Arc, F-21000 Dijon, France - EPHE, PSL Research University, F-75014 Paris, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Plenchette
authors.affiliation: Université de Bourgogne Franche-Comté, LIIC EA7269, 7, boulevard Jeanne d'Arc, F-21000 Dijon, France - EPHE, PSL Research University, F-75014 Paris, France.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Romagny
authors.affiliation: Université de Bourgogne Franche-Comté, LIIC EA7269, 7, boulevard Jeanne d'Arc, F-21000 Dijon, France - EPHE, PSL Research University, F-75014 Paris, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Laurens
authors.affiliation: Université de Bourgogne Franche-Comté, LIIC EA7269, 7, boulevard Jeanne d'Arc, F-21000 Dijon, France - EPHE, PSL Research University, F-75014 Paris, France.
authors.forename: Ali
authors.initials: A
authors.lastname: Bettaieb
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*; D009569:Nitric Oxide / Q000494:pharmacology / Q000502:physiology*; D015538:Nitrosation; D011499:Protein Processing, Post-Translational; D026361:Reactive Nitrogen Species / Q000378:metabolism / Q000633:toxicity; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D026361:Reactive Nitrogen Species; D009569:Nitric Oxide