title: Prevalence of Eligibility Criteria for the Systolic Blood Pressure Intervention Trial in US Adults Among Excluded Groups: Age <50 Years, Diabetes Mellitus, or a History of Stroke.
abstract: Adults <50 years old, with diabetes mellitus, or a history of stroke were not enrolled in the Systolic Blood Pressure Intervention Trial (SPRINT). Estimating the size and characteristics of these excluded groups who meet the other SPRINT eligibility criteria may provide information on the potential impact of providers extending the SPRINT findings to these populations.
  
  
  
  We analyzed the National Health and Nutrition Examination Survey 2003-2012 (n=25 076) to estimate the percentage and characteristics of US adults ≥20 years in 3 populations (age <50 years, diabetes mellitus, or history of stroke) excluded from SPRINT who otherwise meet the trial eligibility criteria: age ≥50 years, systolic blood pressure (SBP) 130-180 mm Hg, high cardiovascular disease risk, and not having trial exclusion criteria. Overall, 1.0% (95% CI 0.8-1.3) of US adults age <50 years, 25.4% (95% CI 23.4-27.6) with diabetes mellitus, and 19.0% (95% CI 16.0-22.4) with history of stroke met the other SPRINT eligibility criteria. Among US adults with SBP ≥130 mm Hg, other SPRINT eligibility criteria were met by 7.5% (95% CI 6.1-9.2) of those age <50 years, 32.9% (95% CI 30.5-35.4) with diabetes mellitus, and 23.0% (95% CI 19.4-27.0) with history of stroke. Among US adults meeting the other SPRINT eligibility criteria, antihypertensive medication was being taken by 31.0% (95% CI 23.9-41.3) of those <50 years, 63.0% (95% CI 58.2-67.6) with diabetes mellitus, and 68.9% (95% CI 59.4-77.1) with a history of stroke.
  
  
  
  A substantial percentage of US adults with diabetes mellitus or history of stroke and a small percentage <50 years old meet the other SPRINT eligibility criteria.
authors.affiliation: Department of Pharmacotherapy, University of Utah, Salt Lake City, UT Department of Population Health Sciences, University of Utah, Salt Lake City, UT adam.bress@pharm.utah.edu.
authors.forename: Adam P
authors.initials: AP
authors.lastname: Bress
authors.affiliation: Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, AL.
authors.forename: Rikki M
authors.initials: RM
authors.lastname: Tanner
authors.affiliation: Department of Population Health Sciences, University of Utah, Salt Lake City, UT Department of Internal Medicine, University of Utah, Salt Lake City, UT.
authors.forename: Rachel
authors.initials: R
authors.lastname: Hess
authors.affiliation: Nemours Cardiac Center, Alfred I. DuPont Hospital for Children, Wilmington, DE.
authors.forename: Samuel S
authors.initials: SS
authors.lastname: Gidding
authors.affiliation: Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, AL.
authors.forename: Lisandro D
authors.initials: LD
authors.lastname: Colantonio
authors.affiliation: Department of Medicine, Columbia University, New York, NY.
authors.forename: Daichi
authors.initials: D
authors.lastname: Shimbo
authors.affiliation: Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, AL.
authors.forename: Paul
authors.initials: P
authors.lastname: Muntner
mesh_terms: D000328:Adult; D000367:Age Factors; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D003920:Diabetes Mellitus / Q000453:epidemiology*; D004608:Eligibility Determination; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009749:Nutrition Surveys; D015995:Prevalence; D016032:Randomized Controlled Trials as Topic; D020521:Stroke / Q000453:epidemiology*; D013599:Systole; D014481:United States / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000959:Antihypertensive Agents
keywords: diabetes mellitus; high blood pressure; hypertension; stroke; systolic blood pressure; systolic blood pressure intervention trial; treatment