title: A New Diketopiperazine, Cyclo(D-trans-Hyp-L-Leu) from a Kenyan Bacterium Bacillus licheniformis LB 8CT.
abstract: Bacterially-produced small molecules demonstrate a wide range of structural and functional diversity. A new diketopiperazine, cyclo(D-trans-Hyp-L-Leu) (1), and five other known diketopiperazines (2-6), were isolated and purified from the fermented broth of a Kenyan bacterium Bacillus licheniformis LB 8CT. The structure of 1 was elucidated by a combination of extensive spectroscopic analyses, including 2D NMR and HR-MS, and the absolute configuration was determined by a combination of NOESY analysis and Marfey's method. The known compounds were identified as cyclo(D-cis-Hyp-L-Leu) (2), cyclo(D-cis-Hyp-L-Phe) (3), cyclo(D-Pro-L-Tyr) (4), cyclo-(D-Trp-L-Leu) (5), and cyclo(L-Tyr-Gly) (6) by comparison of their spectroscopic and physical data with reported values. Compounds 1-6 were tested for antifungal and antimicrobial properties.
authors.forename: Seoung Rak
authors.initials: SR
authors.lastname: Lee
authors.forename: Christine
authors.initials: C
authors.lastname: Beemelmanns
authors.forename: Leah M M
authors.initials: LM
authors.lastname: Tsuma
authors.forename: Jon
authors.initials: J
authors.lastname: Clardy
authors.forename: Shugeng
authors.initials: S
authors.lastname: Cao
authors.forename: Ki Hyun
authors.initials: KH
authors.lastname: Kim
mesh_terms: D001407:Bacillus / Q000737:chemistry*; D054659:Diketopiperazines / Q000737:chemistry / Q000302:isolation & purification*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D054659:Diketopiperazines; D010456:Peptides, Cyclic; C000611025:cyclo(D-trans-Hyp-L-Leu)