title: Intranasal midazolam for seizure cessation in the community setting.
abstract: OBJECTIVE
  There are times when parents arrive to my clinic after their child has had a seizure and a second seizure takes place in the clinic. While waiting for transport to the hospital, are there ways to stop the seizures without the need to obtain intravenous access in the clinic?
  
  
  CONCLUSIONS
  Intravenous diazepam has been a first-line therapy to stop seizures in children for many years. Other routes of drug administration such as intramuscular, rectal, and buccal are available but have several limitations. More evidence suggests that the intranasal route to administer drugs is quick and effective in children, and the use of midazolam has been continuing to show promise in seizure cessation. With its good safety profile, intranasal midazolam can be used in the clinic and prehospital setting for seizure cessation in children.
authors.forename: Michal
authors.initials: M
authors.lastname: Zelcer
authors.forename: Ran D
authors.initials: RD
authors.lastname: Goldman
mesh_terms: D000281:Administration, Intranasal; D000554:Ambulatory Care Facilities; D000927:Anticonvulsants / Q000008:administration & dosage* / Q000009:adverse effects; D002648:Child; D003975:Diazepam / Q000008:administration & dosage; D006801:Humans; D008874:Midazolam / Q000008:administration & dosage* / Q000009:adverse effects; D016032:Randomized Controlled Trials as Topic; D012640:Seizures / Q000188:drug therapy*; D013226:Status Epilepticus / Q000188:drug therapy; D014187:Transportation of Patients
chemical_list: D000927:Anticonvulsants; D003975:Diazepam; D008874:Midazolam