title: Relationship between platelet-leukocyte aggregation and myocardial perfusion in patients with ST-segment elevation myocardial infarction after primary percutaneous coronary intervention.
abstract: To explore the relationship between inflammation, oxidative stress and poor myocardial perfusion in patients with acute ST-segment elevation myocardial infarction (STEMI) after primary percutaneous coronary intervention (PCI).
  
  
  
  Risk factors and mechanisms of poor reperfusion in patients with STEMI after primary PCI remain unclear.
  
  
  
  A total of 143 patients who underwent primary PCI after STEMI were divided into good and poor perfusion groups according to sum-ST-segment resolution (sumSTR) and TIMI myocardial perfusion grade (TMP) results. Aortic sinus arterial blood was collected after primary PCI. The platelet-leukocyte aggregation (PLA), platelet-neutrophil aggregation (PNA), platelet-monocyte aggregation (PMA) and platelet-lymphocyte aggregation (PLyA) were measured by flow cytometry. The malondialdehyde (MDA) and superoxide dismutase (SOD) levels were measured by chemical colorimetry.
  
  
  
  The leukocyte count, neutrophil ratio and high-sensitivity C-reactive protein were significantly higher in the poor perfusion group than the good perfusion group (p < 0.05). Multiple linear regression analysis showed that neutrophil ratio was an independent risk factor of sumSTR in STEMI patients after primary PCI (p < 0.01). The poor myocardial perfusion group had higher levels of PLA, PNA, PMA and MDA (p < 0.05). There were no differences in PLyA and SOD levels between the good and poor myocardial perfusion groups (p > 0.05).
  
  
  
  Inflammation and oxidative stress were related to poor myocardial perfusion in patients with STEMI after primary PCI.
authors.affiliation: Department of Cardiology, Liaocheng People's Hospital, Liaocheng Clinical School of Taishan Medical University, Liaocheng 252000, Shandong, China. Electronic address: 13346256309@163.com.
authors.forename: Guang-Yong
authors.initials: GY
authors.lastname: Huang
authors.affiliation: Department of Cardiology, Liaocheng People's Hospital, Liaocheng Clinical School of Taishan Medical University, Liaocheng 252000, Shandong, China.
authors.forename: Lan-Ju
authors.initials: LJ
authors.lastname: Yang
authors.affiliation: Department of Cardiology, Liaocheng People's Hospital, Liaocheng Clinical School of Taishan Medical University, Liaocheng 252000, Shandong, China.
authors.forename: Xiao-Hua
authors.initials: XH
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Liaocheng People's Hospital, Liaocheng Clinical School of Taishan Medical University, Liaocheng 252000, Shandong, China.
authors.forename: Ying-Li
authors.initials: YL
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Liaocheng People's Hospital, Liaocheng Clinical School of Taishan Medical University, Liaocheng 252000, Shandong, China.
authors.forename: Yu-Zeng
authors.initials: YZ
authors.lastname: Xue
authors.affiliation: Department of Cardiology, Rui Jin Hospital Shanghai Jiaotong University School of Medicine, Shanghai 200025, China; Institute of Cardiovascular Diseases, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China. Electronic address: 15800529807@163.com.
authors.forename: Wen-Bo
authors.initials: WB
authors.lastname: Yang
mesh_terms: D001792:Blood Platelets / Q000502:physiology*; D017023:Coronary Angiography; D003326:Coronary Circulation / Q000502:physiology*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D007962:Leukocytes / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention; D010974:Platelet Aggregation / Q000502:physiology*; D011184:Postoperative Period; D012307:Risk Factors; D000072657:ST Elevation Myocardial Infarction / Q000097:blood* / Q000175:diagnosis / Q000601:surgery
keywords: Inflammation; Myocardial infarction; Myocardial reperfusion; Oxidative stress; Platelet-leukocyte aggregation