title: Bullous Scabies.
abstract: Scabies is a common contagious cutaneous disease and usually affects the young, characterized by polymorphous lesions that may present as burrows, pruritic papules, and inflammatory nodules. Bullous scabies (BS) is its rather rare subtype, mimicking bullous pemphigoid. We report a 15-year-old Chinese boy presenting with 1-month history of pruritic bullae on his penile skin, showing poor response to both topical steroids and systemic antihistamines, but cured by sulfur ointment alone. No recurrence occurred in the 5 years of follow-up. We also reviewed the published cases. Up to date, 44 cases, including the present, have been reported. Of them, 30 were male and 14 were female. The age range was from 1 to 89 years old, with a median age of 70.6 years. The bullous lesions may involve the arms, legs, trunk, genitals, feet, buttocks, thighs, neck, inguinal folds, and may even be generalized. Trunk and extremities are the most common involved locations. Facial or mucosa involvement had never been reported. The histological findings present as a subepidermal split with variable inflammatory infiltrate predominantly neutrophils, and eosinophilic spongiosis, or both. Eighteen of 32 patients showed positive deposition of linear-granular IgG or complement 3 alone or in various combinations, and five of 24 patients revealed circulating IgG. All the 40 cases with therapeutic details were cured by antiscabietic remedy. BS always involves the trunk and extremities. It has a predilection for elderlies and males. The treatments for BS are similar to those of classical scabies.
authors.affiliation: Department of Dermatology, The Eastern Hospital of The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. luodq@mail.sysu.edu.cn.
authors.forename: Di-Qing
authors.initials: DQ
authors.lastname: Luo
authors.affiliation: Department of Dermatology, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
authors.forename: Mei-Xing
authors.initials: MX
authors.lastname: Huang
authors.affiliation: Department of Dermatology, The Eastern Hospital of The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
authors.forename: Juan-Hua
authors.initials: JH
authors.lastname: Liu
authors.affiliation: Department of Paediatrics, The Eastern Hospital of The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Tang
authors.affiliation: Department of Dermatology, The Eastern Hospital of The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
authors.forename: Yu-Kun
authors.initials: YK
authors.lastname: Zhao
authors.affiliation: Department of Dermatology, Maulana Azad Medical College-Lok Nayak Jai Prakash Narayan (LNJP) Hospital, New Delhi, India.
authors.forename: Rashmi
authors.initials: R
authors.lastname: Sarkar
mesh_terms: D000293:Adolescent; D001768:Blister / Q000469:parasitology* / Q000473:pathology; D006801:Humans; D008297:Male; D010413:Penis; D012532:Scabies / Q000473:pathology*; D012867:Skin / Q000469:parasitology / Q000473:pathology*