title: Nanomedicine therapeutics and diagnostics are the goal.
abstract: Understanding and exploiting molecular mechanisms in biology is central to chemical biology. In 20 years, chemical biology research has advanced from simple mechanistic studies using isolated biological macromolecules to molecular-level and nanomolecular-level mechanistic studies involving whole organisms. This review documents the best of my personal and collaborative academic research work that has made use of a solid organic chemistry and chemical biology approach toward nanomedicine, in which my focus has been on the design, creation and use of synthetic, self-assembly lipid-based nanoparticle technologies for the functional delivery of active pharmaceutical ingredients to target cells in vivo. This research is now leading to precision therapeutics approaches (PTAs) for the treatment of diseases that may define the future of nanomedicine.
authors.affiliation: Institute of Pharmaceutical Science, Kings College London, Franklin-Wilkins Building, Waterloo Campus, 150 Stamford Street, London SE1 9NH, UK.|KP Therapeutics Ltd, 86 Deansgate, Manchester, M3 2ER, UK.
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Miller
mesh_terms: D000818:Animals; D008055:Lipids; D050997:Nanomedicine; D053758:Nanoparticles
chemical_list: D008055:Lipids
keywords: RNA interference; active pharmaceutical ingredient; biophysics; lipid-based nanoparticles; nanomedicine; nanotechnology; plasmid DNA; precision medicine; precision therapeutics; small interfering RNA