title: HLA-B27 allele frequency in Sri Lankan patients with spondyloarthritides.
abstract: This preliminary study aims to describe the HLA-B27 allele frequency in Sri Lankan patients with spondyloarthritides (SA). An anonymised database of 373 Sri Lankan patients with SA referred for HLA-B27 testing was retrospectively analysed. Eighty five (22.8%) patients were positive for the HLA-B27 allele. A male preponderance was observed among the positives. The HLA-B27 allele frequency in this sample of patients with SA was relatively low compared to published studies in other populations. Further research is needed to identify the predominant subtypes of the allele to determine which subtypes are the most prevalent in a larger sample of Sri Lankan patients with SA, and to define their association with the specific types of SA.
authors.forename: S
authors.initials: S
authors.lastname: Kidnapillai
authors.forename: N D
authors.initials: ND
authors.lastname: Sirisena
authors.affiliation: Human Genetics Unit, Faculty of Medicine, University of Colombo, Sri Lanka. vajirahwd@hotmail.com.
authors.forename: V H
authors.initials: VH
authors.lastname: Dissanayake
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D015796:HLA-B27 Antigen / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D025242:Spondylarthropathies / Q000235:genetics*; D013188:Sri Lanka; D055815:Young Adult
chemical_list: D015796:HLA-B27 Antigen