title: Plurihormonal Cosecretion by a Case of Adrenocortical Oncocytic Neoplasm.
abstract: Adrenocortical oncocytic neoplasms (oncocytomas) are extremely rare; only approximately 159 cases have been described so far. The majority are nonfunctional and benign. We describe an unusual case of a functional oncocytoma secreting an excess of glucocorticoids (cortisol) and androgens (androstenedione and DHEAS), a pattern of plurihormonal cosecretion previously not reported in men, presenting with endocrine manifestations of Cushing's syndrome. The neoplasm was considered to be of uncertain malignant potential (borderline) according to the Lin-Weiss-Bisceglia criteria.
authors.affiliation: Servicio de Endocrinología y Nutrición, Hospital Clínico Universitario, Paseo de San Vicente No. 58, 37007 Salamanca, Spain; Departamento de Medicina, Universidad de Salamanca, Campus Miguel de Unamuno s/n, 37007 Salamanca, Spain; Centro de Investigación del Cáncer (IBMCC-CSIC/USAL) and Instituto Biosanitario de Salamanca, Campus Miguel de Unamuno s/n, 37007 Salamanca, Spain.
authors.forename: J J
authors.initials: JJ
authors.lastname: Corrales
authors.affiliation: Servicio de Endocrinología y Nutrición, Hospital Clínico Universitario, Paseo de San Vicente No. 58, 37007 Salamanca, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Robles-Lázaro
authors.affiliation: Servicio de Endocrinología y Nutrición, Hospital Clínico Universitario, Paseo de San Vicente No. 58, 37007 Salamanca, Spain; Departamento de Medicina, Universidad de Salamanca, Campus Miguel de Unamuno s/n, 37007 Salamanca, Spain.
authors.forename: A I
authors.initials: AI
authors.lastname: Sánchez-Marcos
authors.affiliation: Unidad de Cirugía Endocrina, Departamento de Cirugía, Hospital Clínico Universitario de Salamanca, Paseo de San Vicente No. 58, 37007 Salamanca, Spain.
authors.forename: M C
authors.initials: MC
authors.lastname: González-Sánchez
authors.affiliation: Servicio de Anatomía Patológica, Departamento de Anatomía Patológica, Hospital Universitario de Salamanca, Paseo de San Vicente No. 58, 37007 Salamanca, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Antúnez-Plaza
authors.affiliation: Servicio de Endocrinología y Nutrición, Hospital Clínico Universitario, Paseo de San Vicente No. 58, 37007 Salamanca, Spain; Departamento de Medicina, Universidad de Salamanca, Campus Miguel de Unamuno s/n, 37007 Salamanca, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Miralles