title: Flavonoid-surfactant interactions: A detailed physicochemical study.
abstract: The aim of this article is to study the interactions between flavonoids and surfactants with attention of finding the probable location of flavonoids in micellar media that can be used for controlling their antioxidant behavior. In present study, the micellar and interfacial behavior of twin tailed anionic surfactants viz. sodium bis(2-ethylhexyl)sulfosuccinate (AOT) and sodium bis(2-ethylhexyl)phosphate (NaDEHP) in the presence of two flavonoids, namely quercetin (QUE) and kaempferol (KFL) have been studied by surface tension measurements. UV-visible, fluorescence and differential pulse voltammetric (DPV) measurements have been employed to predict the probable location of flavonoids (QUE/KFL) within surfactant (AOT/NaDEHP) aggregates. Dynamic light scattering (DLS) measurements further confirmed the solubilization of QUE/KFL in AOT/NaDEHP aggregates deduced from increased hydrodynamic diameter (Dh) of aggregates in the presence of flavonoids. Both radical scavenging activity (RSA) and degradation rate constant (k) of flavonoids are found to be higher in NaDEHP micelles as compared to AOT micelles.
authors.affiliation: Department of Chemistry, UGC-centre for Advanced Studies-II, Guru Nanak Dev University, Amritsar-143005, India.
authors.forename: Onkar
authors.initials: O
authors.lastname: Singh
authors.affiliation: Department of Chemistry, UGC-centre for Advanced Studies-II, Guru Nanak Dev University, Amritsar-143005, India.
authors.forename: Rajwinder
authors.initials: R
authors.lastname: Kaur
authors.affiliation: Department of Chemistry, UGC-centre for Advanced Studies-II, Guru Nanak Dev University, Amritsar-143005, India. Electronic address: rakesh_chem@yahoo.com.
authors.forename: Rakesh Kumar
authors.initials: RK
authors.lastname: Mahajan
mesh_terms: D055598:Chemical Phenomena; D000067493:Dynamic Light Scattering; D004563:Electrochemistry; D005419:Flavonoids / Q000737:chemistry*; D057446:Hydrodynamics; D017665:Hydroxyl Radical / Q000737:chemistry; D008823:Micelles; D010084:Oxidation-Reduction; D012995:Solubility; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D013500:Surface Tension; D013501:Surface-Active Agents / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D005419:Flavonoids; D008823:Micelles; D013501:Surface-Active Agents; D017665:Hydroxyl Radical
keywords: Antioxidant activity; Binding constant; Flavonoid; Surfactant