title: Synthesis and Biological Activities of 8'-Methylene- and 8'-Methylidyneabscisic Acids.
abstract: 8'-Methylene- and 8'-methylidyneabscisic acids which might act as suicide inhibitors of the 8'-hydroxylase of abscisic acid, were designed, synthesized, and optically resolved. The (+)-isomers showed stronger inhibitory activity in rice elongation and in lettuce seed germination than (+)-abscisic acid. The activity of (+)-8'-methylidyneabscisic acid was the strongest of the analogues synthesized to date, 40-fold stronger than abscisic acid.
authors.affiliation: a Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University , Kitashirakawa-oiwake-cho, Sakyo-ku, Kyoto 606-01 , Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Todoroki
authors.affiliation: a Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University , Kitashirakawa-oiwake-cho, Sakyo-ku, Kyoto 606-01 , Japan.
authors.forename: S
authors.initials: S
authors.lastname: Nakano
authors.affiliation: a Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University , Kitashirakawa-oiwake-cho, Sakyo-ku, Kyoto 606-01 , Japan.
authors.forename: S
authors.initials: S
authors.lastname: Arai
authors.affiliation: a Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University , Kitashirakawa-oiwake-cho, Sakyo-ku, Kyoto 606-01 , Japan.
authors.forename: N
authors.initials: N
authors.lastname: Hirai
authors.affiliation: a Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University , Kitashirakawa-oiwake-cho, Sakyo-ku, Kyoto 606-01 , Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ohigashi
keywords: 8′-methyleneabscisic acid; 8′-methylidyneabscisic acid; abscisic acid; cytochrome P-450 monooxygenase; suicide inhibitor