title: Evidence for bisphenol A-induced female infertility: a review (2007-2016).
abstract: We summarized the scientific literature published from 2007 to 2016 on the potential effects of bisphenol A (BPA) on female fertility. We focused on overall fertility outcomes (e.g., ability to become pregnant, number of offspring), organs that are important for female reproduction (i.e., oviduct, uterus, ovary, hypothalamus, and pituitary), and reproductive-related processes (i.e., estrous cyclicity, implantation, and hormonal secretion). The reviewed literature indicates that BPA may be associated with infertility in women. Potential explanations for this association can be generated from experimental studies. Specifically, BPA may alter overall female reproductive capacity by affecting the morphology and function of the oviduct, uterus, ovary, and hypothalamus-pituitary-ovarian axis in animal models. In addition, BPA may disrupt estrous cyclicity and implantation. Nevertheless, further studies are needed to better understand the exact mechanisms of action and to detect potential reproductive toxicity at earlier stages.
authors.affiliation: School of Food and Nutrition, Massey University, Palmerston North, New Zealand.
authors.forename: Ayelet
authors.initials: A
authors.lastname: Ziv-Gal
authors.affiliation: Comparative Biosciences, University of Illinois at Urbana-Champaign, Urbana, Illinois. Electronic address: jflaws@illinois.edu.
authors.forename: Jodi A
authors.initials: JA
authors.lastname: Flaws
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds / Q000633:toxicity*; D010064:Embryo Implantation / Q000187:drug effects; D052244:Endocrine Disruptors / Q000009:adverse effects*; D004781:Environmental Exposure / Q000009:adverse effects*; D004785:Environmental Pollutants / Q000009:adverse effects*; D030762:Estrous Cycle / Q000187:drug effects; D005260:Female; D005298:Fertility / Q000187:drug effects*; D005836:Genitalia, Female / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000503:physiopathology; D007247:Infertility, Female / Q000139:chemically induced* / Q000503:physiopathology; D008597:Menstrual Cycle / Q000187:drug effects; D010636:Phenols / Q000633:toxicity*; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D012098:Reproduction / Q000187:drug effects*; D018570:Risk Assessment; D012307:Risk Factors; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D004785:Environmental Pollutants; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Infertility; bisphenol A; female; hypothalamus; implantation; ovary; pituitary; uterus