title: Continuous plasma perfusion of dual cartridges in series: rationale and early clinical experience.
abstract: To improve the efficiency of plasma perfusion on eliminating plasma paraquat (PQ), we designed continuous plasma perfusion of dual cartridges in series (CPPDCS) on Diapact Braun CRRT machine. The goals of this study were to evaluate the effective of CPPDCS on paraquat removal in patients with acute paraquat intoxication. Our results show that the PQ clearance rate of dual cartridges was significantly higher than that of single cartridge at 1st, 2nd, 3rd, and 4th plasma perfusion. Compared with single-cartridge plasma perfusion, CPPDCS significantly reduced the frequency of cartridge replacement, shorten the time of perfusion. These results indicate that CPPDCS is effective than plasma perfusion of single cartridge on PQ clearance rate and may provide an effective treatment for PQ poisoning.
authors.affiliation: Department of Respiratory and Critical Care Medicine of Ping Jing Hospital, Affiliated Hospital of Logistic University of Chinese People's Armed Police Force, 220#, Cheng-Lin Road, Tianjin, 300162, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Sun
authors.affiliation: Department of Respiratory and Critical Care Medicine of Ping Jing Hospital, Affiliated Hospital of Logistic University of Chinese People's Armed Police Force, 220#, Cheng-Lin Road, Tianjin, 300162, China.
authors.forename: Peng-Bo
authors.initials: PB
authors.lastname: Yan
authors.affiliation: Department of Respiratory and Critical Care Medicine of Ping Jing Hospital, Affiliated Hospital of Logistic University of Chinese People's Armed Police Force, 220#, Cheng-Lin Road, Tianjin, 300162, China.
authors.forename: Yu-Hua
authors.initials: YH
authors.lastname: Zhang
authors.affiliation: Department of Respiratory and Critical Care Medicine of Ping Jing Hospital, Affiliated Hospital of Logistic University of Chinese People's Armed Police Force, 220#, Cheng-Lin Road, Tianjin, 300162, China.
authors.forename: Lu-Qing
authors.initials: LQ
authors.lastname: Wei
authors.affiliation: Department of Respiratory and Critical Care Medicine of Ping Jing Hospital, Affiliated Hospital of Logistic University of Chinese People's Armed Police Force, 220#, Cheng-Lin Road, Tianjin, 300162, China. sunliangys@sina.com.
authors.forename: Guo-Qiang
authors.initials: GQ
authors.lastname: Li
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010269:Paraquat / Q000506:poisoning*; D010477:Perfusion; D010956:Plasmapheresis / Q000295:instrumentation* / Q000379:methods; D011041:Poisoning / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D010269:Paraquat
keywords: Diapact Braun CRRT machine; Dual cartridges; Plasma adsorption/perfusion; Treatment