title: Urinary micafungin levels are sufficient to treat urinary tract infections caused by Candida spp.
abstract: Six cases of patients diagnosed with urinary tract infection (UTI) successfully treated with micafungin are reported. Four were infected with fluconazole-resistant Candida spp. and two (with hepatic injury) were infected with fluconazole-sensitive Candida spp. Traditionally, echinocandins have not been considered for the treatment of UTIs. However, despite its low urinary excretion rate, therapeutic drug monitoring of micafungin urinary levels could be helpful in order to achieve optimal pharmacokinetic/pharmacodynamic (PK/PD) indices for treating UTIs caused by Candida spp. resistant to fluconazole.
authors.affiliation: Pharmacy Service, Hospital del Mar, Barcelona, Spain; Universitat Autònoma de Barcelona, Barcelona, Spain; Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain. Electronic address: sgrau@parcdesalutmar.cat.
authors.forename: S
authors.initials: S
authors.lastname: Grau
authors.affiliation: Pharmacy Service, Hospital del Mar, Barcelona, Spain; Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Luque
authors.affiliation: Pharmacy Service, Hospital del Mar, Barcelona, Spain; Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain.
authors.forename: D
authors.initials: D
authors.lastname: Echeverría-Esnal
authors.affiliation: Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain; Infectious Diseases Service, Hospital del Mar, Barcelona, Spain; CEXS, Universitat Pompeu Fabra, Barcelona, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Sorlí
authors.affiliation: Pharmacy Service, Hospital del Mar, Barcelona, Spain; Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain.
authors.forename: N
authors.initials: N
authors.lastname: Campillo
authors.affiliation: Universitat Autònoma de Barcelona, Barcelona, Spain; Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain; Infectious Diseases Service, Hospital del Mar, Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Montero
authors.affiliation: Universitat Autònoma de Barcelona, Barcelona, Spain; Intensive Care Unit, Hospital del Mar, Barcelona, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Álvarez Lerma
authors.affiliation: Laboratori de Referència de Catalunya, Prat de Llobregat, Barcelona, Spain.
authors.forename: V
authors.initials: V
authors.lastname: Plasencia
authors.affiliation: Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain; Infectious Diseases Service, Hospital del Mar, Barcelona, Spain; CEXS, Universitat Pompeu Fabra, Barcelona, Spain; CIBERES, Instituto de Salud Carlos III, Spain.
authors.forename: J P
authors.initials: JP
authors.lastname: Horcajada
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002175:Candida / Q000187:drug effects; D002177:Candidiasis / Q000188:drug therapy*; D016903:Drug Monitoring; D054714:Echinocandins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D055666:Lipopeptides / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D000077551:Micafungin; D008875:Middle Aged; D011446:Prospective Studies; D014552:Urinary Tract Infections / Q000188:drug therapy*; D014556:Urine / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077551:Micafungin
keywords: Candida spp; Fluconazole-resistant; Micafungin; Urinary tract infection