title: [Evaluation of the effects of intra-arterial sugammadex and dexmedetomidine: an experimental study].
abstract: BACKGROUND
  Intra-arterial injection of medications may cause acute and severe ischemia and result in morbidity and mortality. There is no information in the literature evaluating the arterial endothelial effects of sugammadex and dexmedetomidine. The hypothesis of our study is that sugammadex and dexmedetomidine will cause histological changes in arterial endothelial structure when administered intra-arterially.
  
  
  METHODS
  Rabbits were randomly divided into 4 groups. Group Control (n=7); no intervention performed. Group Catheter (n=7); a cannula inserted in the central artery of the ear, no medication was administered. Group Sugammadex (n=7); rabbits were given 4mg/kg sugammadex into the central artery of the ear, and Group Dexmedetomidine (n=7); rabbits were given 1μg/kg dexmedetomidine into the central artery of the ear. After 72h, the ears were amputated and histologically investigated.
  
  
  RESULTS
  There was no significant difference found between the control and catheter groups in histological scores. The endothelial damage, elastic membrane and elastic fiber damage, smooth muscle hypertrophy and connective tissue increase scores in the dexmedetomidine and sugammadex groups were significantly higher than both the control and the catheter groups (p<0.05). There was no significant difference found between the dexmedetomidine and sugammadex groups in histological scores.
  
  
  CONCLUSIONS
  Administration of sugammadex and dexmedetomidine to rabbits by intra-arterial routes caused histological arterial damage. To understand the histological changes caused by sugammadex and dexmedetomidine more clearly, more experimental research is needed.
authors.affiliation: Dokuz Eylül University, School of Medicine, Department of Anesthesiology and Reanimation, İnciraltı, İzmir, Turquia. Electronic address: vhanci@gmail.com.
authors.forename: Volkan
authors.initials: V
authors.lastname: Hancı
authors.affiliation: Dokuz Eylül University, School of Medicine, Department of Histology and Embryology, İnciraltı, İzmir, Turquia.
authors.forename: Şule
authors.initials: Ş
authors.lastname: Özbilgin
authors.affiliation: Dokuz Eylül University, School of Medicine, Department of Histology and Embryology, İnciraltı, İzmir, Turquia.
authors.forename: Seda
authors.initials: S
authors.lastname: Özbal
authors.affiliation: Dokuz Eylül University, School of Medicine, Department of Experienced Laboratory Animal Science, İnciraltı, İzmir, Turquia.
authors.forename: Gonca
authors.initials: G
authors.lastname: Kamacı
authors.affiliation: Dokuz Eylül University, School of Medicine, Department of Plastic, Reconstructive and Aesthetic Surgery, İnciraltı, İzmir, Turquia.
authors.forename: Hasan
authors.initials: H
authors.lastname: Ateş
authors.affiliation: Dokuz Eylül University, School of Medicine, Department of Anesthesiology and Reanimation, İnciraltı, İzmir, Turquia.
authors.forename: Nilay
authors.initials: N
authors.lastname: Boztaş
authors.affiliation: Dokuz Eylül University, School of Medicine, Department of Histology and Embryology, İnciraltı, İzmir, Turquia.
authors.forename: Bekir Uğur
authors.initials: BU
authors.lastname: Ergür
authors.affiliation: Dokuz Eylül University, School of Medicine, Department of Anesthesiology and Reanimation, İnciraltı, İzmir, Turquia.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Arıkanoğlu
authors.affiliation: Dokuz Eylül University, School of Medicine, Department of Experienced Laboratory Animal Science, İnciraltı, İzmir, Turquia.
authors.forename: Osman
authors.initials: O
authors.lastname: Yılmaz
authors.affiliation: Dokuz Eylül University, School of Medicine, Department of Anesthesiology and Reanimation, İnciraltı, İzmir, Turquia.
authors.forename: Bülent Serhan
authors.initials: BS
authors.lastname: Yurtlu
keywords: Coelho; Dexmedetomidina; Dexmedetomidine; Experimental; Intra‐arterial; Rabbit; Sugamadex; Sugammadex