title: Relationships between serum brain-derived neurotrophic factor, plasma catecholamine metabolites, cytokines, cognitive function and clinical symptoms in Japanese patients with chronic schizophrenia treated with atypical antipsychotic monotherapy.
abstract: Catecholamines, brain-derived neurotrophic factor (BDNF) and cytokines may be involved in the pathophysiology of schizophrenia. The aim of this study was to examine the associations between serum BDNF levels, plasma catecholamine metablolites, cytokines and the cognitive functions of patients with schizophrenia treated with atypical antipsychotic monotherapy.
  
  
  
  One hundred and forty-six patients with schizophrenia and 51 age- and sex-matched healthy controls were examined for peripheral biological markers and neurocognitive test.
  
  
  
  There were positive correlations between serum BDNF levels and scores for verbal memory and attention and processing speed as well as between serum BDNF levels and negative symptoms. Furthermore, there was a negative correlation between the plasma homovanillic acid (HVA) level and motor function and a positive correlation between the plasma 3-methoxy-4-hydroxyphenylglycol (MHPG) level and attention and processing speed. There were no significant correlations between interleukin-6 or tumour necrosis factor alpha and cognitive function. Moreover, there were no significant correlations between the plasma levels of HVA, MHPG, cytokines and clinical symptoms.
  
  
  
  Serum BDNF levels are positively related to the impairment of verbal memory and attention, plasma HVA levels are positively related to motor function, and plasma MHPG levels are positively related to attention in patients with schizophrenia.
authors.affiliation: a Department of Psychiatry , University of Occupational and Environmental Health , Kitakyushu , Fukuoka , Japan.
authors.forename: Hikaru
authors.initials: H
authors.lastname: Hori
authors.affiliation: a Department of Psychiatry , University of Occupational and Environmental Health , Kitakyushu , Fukuoka , Japan.
authors.forename: Reiji
authors.initials: R
authors.lastname: Yoshimura
authors.affiliation: a Department of Psychiatry , University of Occupational and Environmental Health , Kitakyushu , Fukuoka , Japan.
authors.forename: Asuka
authors.initials: A
authors.lastname: Katsuki
authors.affiliation: a Department of Psychiatry , University of Occupational and Environmental Health , Kitakyushu , Fukuoka , Japan.
authors.forename: Kiyokazu
authors.initials: K
authors.lastname: Atake
authors.affiliation: a Department of Psychiatry , University of Occupational and Environmental Health , Kitakyushu , Fukuoka , Japan.
authors.forename: Ryohei
authors.initials: R
authors.lastname: Igata
authors.affiliation: a Department of Psychiatry , University of Occupational and Environmental Health , Kitakyushu , Fukuoka , Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Konishi
authors.affiliation: a Department of Psychiatry , University of Occupational and Environmental Health , Kitakyushu , Fukuoka , Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Nakamura
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D016022:Case-Control Studies; D002908:Chronic Disease; D003071:Cognition; D016207:Cytokines / Q000097:blood; D005260:Female; D006719:Homovanillic Acid / Q000097:blood*; D006801:Humans; D007361:Intelligence Tests; D007564:Japan; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000097:blood*; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012044:Regression Analysis; D012559:Schizophrenia / Q000097:blood* / Q000188:drug therapy; D012565:Schizophrenic Psychology; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D015415:Biomarkers; D019208:Brain-Derived Neurotrophic Factor; D016207:Cytokines; D008734:Methoxyhydroxyphenylglycol; D006719:Homovanillic Acid
keywords: Schizophrenia; brain-derived neurotrophic factor; catecholamine metabolites; cognitive function; cytokines