title: Luteal phase clomiphene citrate for ovulation induction in women with polycystic ovary syndrome: a systematic review and meta-analysis.
abstract: OBJECTIVE
  To assess the efficacy of late luteal phase clomiphene citrate (CC) administration relative to early follicular phase CC for ovulation induction for polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Review.
  
  
  METHODS
  A complete electronic databases including PubMed, Embase, The Cochrane Library, Web of Science, and CBM were searched for relevant randomized controlled trials (RCTs). The search was not restricted by language and publication time. Two reviewers selected trials and assessed trial quality by the Cochrane Handbook 5.1.0 independently.
  
  
  RESULTS
  Four eligible RCT studies involving 708 women (934 cycles) were included. The results of the Meta-analysis: Late luteal phase group was associated with a number of higher total follicles (MD 1.82; 95% CI 0.86-2.78, p < 0.00001) and significant higher endometrial thickness on the day of HCG (MD 0.88; 95% CI 0.78-0.99, p < 0.00001) compared with early follicular group. There were no significant differences in the rate of pregnancy (RR 1.29; 95% CI 0.83-2.01, p = 0.26), ovulation rate (RR 0.99; 95% CI 0.86-1.14, p = 0.87), and abortion rate (RR 1.12; 95% CI 0.38 to 3.29, p = 0.84) between the two groups.
  
  
  CONCLUSIONS
  It appeared that late luteal phase CC for ovulation induction might be an effective method for ovulation induction in women with PCOS compared to conventional CC administration. Further intensive randomized-controlled studies should be warranted to define the efficacy of CC used in late luteal phase.
authors.affiliation: a Reproductive Medicine Center, Lanzhou University Second Hospital , Lanzhou City , China and.
authors.forename: Nan
authors.initials: N
authors.lastname: Ding
authors.affiliation: b Evidence-Based Medicine Centre of Lanzhou University, School of Basic Medicine Sciences of Lanzhou University , Lanzhou City , China.
authors.forename: Jianbo
authors.initials: J
authors.lastname: Chang
authors.affiliation: a Reproductive Medicine Center, Lanzhou University Second Hospital , Lanzhou City , China and.
authors.forename: Qiliang
authors.initials: Q
authors.lastname: Jian
authors.affiliation: a Reproductive Medicine Center, Lanzhou University Second Hospital , Lanzhou City , China and.
authors.forename: Xuefei
authors.initials: X
authors.lastname: Liang
authors.affiliation: a Reproductive Medicine Center, Lanzhou University Second Hospital , Lanzhou City , China and.
authors.forename: Zhongzhen
authors.initials: Z
authors.lastname: Liang
authors.affiliation: a Reproductive Medicine Center, Lanzhou University Second Hospital , Lanzhou City , China and.
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
mesh_terms: D002996:Clomiphene / Q000627:therapeutic use*; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use*; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy* / Q000209:etiology; D008183:Luteal Phase / Q000187:drug effects*; D010062:Ovulation Induction / Q000379:methods*; D011085:Polycystic Ovary Syndrome / Q000150:complications*
chemical_list: D005300:Fertility Agents, Female; D002996:Clomiphene
keywords: Clomiphene citrate; meta-analysis; ovulation induction; polycystic ovary syndrome; randomized controlled trial