title: Assessment of the level of vaccine-induced anti-HBs antibodies in children with inflammatory systemic connective tissue diseases treated with immunosuppression.
abstract: OBJECTIVE
  Protective vaccinations are the most effective method of prevention of type B virus hepatitis. The aim of the study was to determine whether in children receiving immunosuppressive therapy due to inflammatory systemic connective tissue diseases the protective concentration of the anti-HBs antibodies produced after vaccination against type B virus hepatitis in infancy is maintained.
  
  
  METHODS
  The concentration of anti-HBs antibodies was assessed in the sera of 50 children with inflammatory connective tissue diseases - 37 girls (74%) and 13 boys (26%), aged 1.5-17.5 years - during the immunosuppressive treatment, which lasted at least 6 months. The control group consisted of 50 healthy children - 28 girls (56%) and 22 boys (44%) aged 2-17 years. All children were vaccinated in infancy with Engerix B vaccine according to the 0-1-6 months schedule. The antibody concentration of ≥ 10 mIU/ml in patients is regarded as protective.
  
  
  RESULTS
  No protective antibody concentrations were found in 25 cases (50%) in the group of diseased children and only in 2 children in the control group (4%).
  
  
  CONCLUSIONS
  The concentration of vaccine-induced antibodies should be assessed in children with inflammatory systemic connective tissue diseases and, in case of the absence of a protective concentration, revaccination should be started. The use of glucocorticosteroids, synthetic and biological disease-modifying antirheumatic drugs is no contraindication to vaccination against hepatitis B.
authors.affiliation: Department and Polyclinic of Rheumatology of Developmental Age, Institute of Rheumatology in Warsaw, Poland.
authors.forename: Izabela
authors.initials: I
authors.lastname: Szczygielska
authors.affiliation: Department and Polyclinic of Rheumatology of Developmental Age, Institute of Rheumatology in Warsaw, Poland.
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Hernik
authors.affiliation: Department and Polyclinic of Rheumatology of Developmental Age, Institute of Rheumatology in Warsaw, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Kwiatkowska
authors.affiliation: Department and Polyclinic of Rheumatology of Developmental Age, Institute of Rheumatology in Warsaw, Poland.
authors.forename: Lidia
authors.initials: L
authors.lastname: Rutkowska-Sak
authors.affiliation: Department and Polyclinic of Rheumatology of Developmental Age, Institute of Rheumatology in Warsaw, Poland.
authors.forename: Beata
authors.initials: B
authors.lastname: Kołodziejczyk
authors.affiliation: Department and Polyclinic of Rheumatology of Developmental Age, Institute of Rheumatology in Warsaw, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Gazda
keywords: concentration of anti-HBs antibodies; seroprotection; vaccination against virus hepatitis