title: Endogenous Erythropoietin, Tumor Necrosis Factor-α and Interleukin-6 Levels after Peripheral Blood Stem Cell Transplantation.
abstract: We investigated the kinetics of plasma concentrations of endogenous erythropoietin (EPO), tumor necrosis factor-α (TNF) and interleukin-6 (IL-6) in patients with metastatic breast cancer who received high-dose chemotherapy and peripheral blood stem cell transplantation (PBSCT) followed by an administration of recombinant human granulocyte-colony-stimulating factor (rhG-CSF). The plasma levels of these cytokines increased significantly after PBSCT and peak levels were observed on day 6 (median) for EPO, day 14.5 for TNF and day 6 for IL-6. EPO levels inversely correlated with hemoglobin levels (p = 0.0207) but no correlation was found between neutrophil recovery and levels of the cytokines tested. The concentrations of TNF and IL-6 directly correlated with body temperature (p = 0.0470 and <0.0001). The maximum level of IL-6 which occurred within 10 days after PBSCT directly correlated with number of days to achieve a platelet count of >20 X 10(9)/1 (p = 0.0003) and number of platelet transfusions (p = 0.0107), suggesting that the high concentrations of IL-6 could be associated with delayed platelet recovery.
authors.affiliation: a Departments of Medicine , University of Alberta Edmonton , Alberta , Canada.
authors.forename: A
authors.initials: A
authors.lastname: Matsuzaki
authors.affiliation: b Cross Cancer Institute Edmonton , Alberta , Canada.
authors.forename: J M
authors.initials: JM
authors.lastname: Nabholtz
authors.affiliation: c CRCS Blood Centre , Edmonton , Alberta , Canada.
authors.forename: S
authors.initials: S
authors.lastname: Nahirniak
authors.affiliation: c CRCS Blood Centre , Edmonton , Alberta , Canada.
authors.forename: A
authors.initials: A
authors.lastname: Janowska-Wieczorek
keywords: EPO; IL-6; Stem cell transplantation; TNF-α