title: [PPARs Mediate the Regulation of Energy Metabolism By Long-Chain Fatty Acids].
abstract: PPAR-alpha expressed primarily in liver is essential for metabolic adaptation to starvation by inducing genes for beta-oxidation and ketogenesis to increase the utility of LCFAs and fibroblast growth factor 21. PPAR-delta induces genes for LCFA oxidation during fasting and endurance exercise in skeletal muscle. PPAR-delta also regulates glucose metabolism and mitochondrial biogenesis by inducing FOXO1 and PGC1-alpha. PPAR-gamma can induces the pathways to store LCFAs as triglycerides in adipocytes. Adiponectin, another important target of PPAR-gamma may maintain insulin sensitivity between adipocytes. The present review summarize that PPARs mediate the regulation of energy metabolism by long-chain fatty acids.
authors.forename: Yao
authors.initials: Y
authors.lastname: Yan
authors.forename: Zong-Bao
authors.initials: ZB
authors.lastname: Wang
authors.forename: Chao-Ke
authors.initials: CK
authors.lastname: Tang
mesh_terms: D052242:Adiponectin / Q000378:metabolism; D004734:Energy Metabolism; D005227:Fatty Acids / Q000378:metabolism*; D006801:Humans; D007333:Insulin Resistance; D008099:Liver / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism; D001678:Organelle Biogenesis; D010084:Oxidation-Reduction; D047493:PPAR alpha / Q000378:metabolism*; D047494:PPAR delta / Q000378:metabolism*; D047495:PPAR gamma / Q000378:metabolism*; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D014157:Transcription Factors / Q000378:metabolism
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D005227:Fatty Acids; D047493:PPAR alpha; D047494:PPAR delta; D047495:PPAR gamma; C486497:PPARGC1A protein, human; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D014157:Transcription Factors