title: Quantitative hemodynamic PET imaging using image-derived arterial input function and a PET/MR hybrid scanner.
abstract: Positron emission tomography (PET) with15O-tracers is commonly used to measure brain hemodynamic parameters such as cerebral blood flow, cerebral blood volume, and cerebral metabolic rate of oxygen. Conventionally, the absolute quantification of these parameters requires an arterial input function that is obtained invasively by sampling blood from an artery. In this work, we developed and validated an image-derived arterial input function technique that avoids the unreliable and burdensome arterial sampling procedure for full quantitative15O-PET imaging. We then compared hemodynamic PET imaging performed on a PET/MR hybrid scanner against a conventional PET only scanner. We demonstrated the proposed imaging-based technique was able to generate brain hemodynamic parameter measurements in strong agreement with the traditional arterial sampling based approach. We also demonstrated that quantitative15O-PET imaging can be successfully implemented on a PET/MR hybrid scanner.
authors.affiliation: 1 Mallinckrodt Institute of Radiology, Washington University School of Medicine, USA.
authors.forename: Yi
authors.initials: Y
authors.lastname: Su
authors.affiliation: 1 Mallinckrodt Institute of Radiology, Washington University School of Medicine, USA.
authors.forename: Andrei G
authors.initials: AG
authors.lastname: Vlassenko
authors.affiliation: 1 Mallinckrodt Institute of Radiology, Washington University School of Medicine, USA.
authors.forename: Lars E
authors.initials: LE
authors.lastname: Couture
authors.affiliation: 1 Mallinckrodt Institute of Radiology, Washington University School of Medicine, USA.|2 Department Neurosurgery, Washington University School of Medicine, USA.
authors.forename: Tammie Ls
authors.initials: TL
authors.lastname: Benzinger
authors.affiliation: 1 Mallinckrodt Institute of Radiology, Washington University School of Medicine, USA.
authors.forename: Abraham Z
authors.initials: AZ
authors.lastname: Snyder
authors.affiliation: 3 Department of Radiology, University of Iowa, USA.
authors.forename: Colin P
authors.initials: CP
authors.lastname: Derdeyn
authors.affiliation: 1 Mallinckrodt Institute of Radiology, Washington University School of Medicine, USA.|4 Department of Neurology, Washington University School of Medicine, USA.
authors.forename: Marcus E
authors.initials: ME
authors.lastname: Raichle
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging*; D002536:Cerebral Arteries / Q000000981:diagnostic imaging / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010104:Oxygen Radioisotopes; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods*; D055815:Young Adult
chemical_list: D010104:Oxygen Radioisotopes
keywords: Arterial input function; cerebral blood flow; cerebral metabolic rate of oxygen; positron emission tomography