title: Wnt1 and SFRP1 as potential prognostic factors and therapeutic targets in cutaneous squamous cell carcinoma.
abstract: The Wnt signaling pathway plays a key role in insurgence and progression of many different forms of cancer. Some crucial components of the Wnt pathway have been proposed to be novel targets for cancer therapy. To date, the Wnt signaling pathway has not been studied in cutaneous squamous cell carcinoma (CSCC). This study was designed to investigate the expression of Wnt1 and SFRP1 from the Wnt pathway in CSCC. Tissue samples were obtained from 35 patients with CSCC and 30 controls admitted to the Xinjiang Uygur Autonomous Region People's Hospital at Urumchi City, China. Gene and protein expressions of Wnt1 and SFRP1 were quantified by immunohistochemistry and western blotting. Wnt1 expression was significantly higher (P < 0.05) in CSCC samples than in normal skin cells of the control subjects; in contrast, SFRP1 expression was significantly lower in CSCC tissues than that in tissues of control subjects (P < 0.05). Moreover, Wnt1 expression (P < 0.05) was found to be correlated with histopathological differentiation in CSCC, and negatively correlated with SFRP1 expression in CSCC (rs = -0.473, P = 0.015). Therefore, we concluded that Wnt1 and SFRP1 play important roles in the development of CSCC and could be potent markers for diagnosis, prevention, and therapy of CSCC.
authors.affiliation: Department of Dermatology, The People's Hospital of Xinjiang Uyghur Autonomous Region, Urumchi, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Halifu
authors.affiliation: Department of Dermatology, The People's Hospital of Xinjiang Uyghur Autonomous Region, Urumchi, China.
authors.forename: J Q
authors.initials: JQ
authors.lastname: Liang
authors.affiliation: Department of Plastic Surgery, The People's Hospital of Xinjiang Uyghur Autonomous Region, Urumchi, China.
authors.forename: X W
authors.initials: XW
authors.lastname: Zeng
authors.affiliation: Department of Dermatology, The People's Hospital of Xinjiang Uyghur Autonomous Region, Urumchi, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Ding
authors.affiliation: School of Life Sciences, Northwest University, Xi'an, Shaanxi, China.
authors.forename: X Y
authors.initials: XY
authors.lastname: Zhang
authors.affiliation: School of Life Sciences, Northwest University, Xi'an, Shaanxi, China.|National Engineering Research Center for Miniaturized Detection Systems, Xi'an, China.
authors.forename: T B
authors.initials: TB
authors.lastname: Jin
authors.affiliation: Department of Dermatology, The People's Hospital of Xinjiang Uyghur Autonomous Region, Urumchi, China.
authors.forename: B
authors.initials: B
authors.lastname: Yakeya
authors.affiliation: Department of Dermatology, The People's Hospital of Xinjiang Uyghur Autonomous Region, Urumchi, China.
authors.forename: D
authors.initials: D
authors.lastname: Abudu
authors.affiliation: Department of Dermatology, The People's Hospital of Xinjiang Uyghur Autonomous Region, Urumchi, China.
authors.forename: Y M
authors.initials: YM
authors.lastname: Zhou
authors.affiliation: Department of Dermatology, The People's Hospital of Xinjiang Uyghur Autonomous Region, Urumchi, China.
authors.forename: X M
authors.initials: XM
authors.lastname: Liu
authors.affiliation: Department of Dermatology, The People's Hospital of Xinjiang Uyghur Autonomous Region, Urumchi, China.
authors.forename: F X
authors.initials: FX
authors.lastname: Hu
authors.affiliation: Department of Dermatology, The People's Hospital of Xinjiang Uyghur Autonomous Region, Urumchi, China.
authors.forename: L
authors.initials: L
authors.lastname: Chai
authors.affiliation: Department of Dermatology, The People's Hospital of Xinjiang Uyghur Autonomous Region, Urumchi, China.
authors.forename: X J
authors.initials: XJ
authors.lastname: Kang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D016022:Case-Control Studies; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics* / Q000378:metabolism; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D012878:Skin Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D051155:Wnt1 Protein / Q000235:genetics* / Q000378:metabolism; D000094742:Secreted Frizzled-Related Proteins
chemical_list: D014408:Biomarkers, Tumor; D036341:Intercellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D051155:Wnt1 Protein; C117636:SFRP1 protein, human; D000094742:Secreted Frizzled-Related Proteins; C495247:WNT1 protein, human