title: Protection induced by a commercial bivalent vaccine against Foot-and-Mouth Disease 2010 field virus from Ecuador.
abstract: Foot-and-Mouth Disease serotype O circulated endemically in Ecuador for many years, with an upsurge occurring in 2009. This manuscript describes retrospectively in vitro and in vivo laboratory studies to predict the field effectiveness of a commercial FMD vaccine to protect against the field strain, and explains the key actions and epidemiological strategies followed by the country to control the disease. The results established that the use of a good quality oil vaccine, manufactured with strains that were isolated long ago: O1 Campos Br/58 and A24 Cruzeiro Br/55; combined with the correct epidemiological strategies, are useful to control field strains when used in periodic biannual vaccination campaigns.
authors.affiliation: Foreign Animal Disease Diagnostic Laboratory (FADDL), APHIS, USDA, Plum Island Animal Disease Center (PIADC), Greenport, NY, USA.
authors.forename: Hernando
authors.initials: H
authors.lastname: Duque
authors.affiliation: Pan-American Foot-and-Mouth Disease Center - PANAFTOSA/PAHO, Av. Governador Leonel de Moura Brizola 7778, Duque de Caxias, RJ CEP 25045-002, Brazil.
authors.forename: Jose
authors.initials: J
authors.lastname: Naranjo
authors.affiliation: Foreign Animal Disease Diagnostic Laboratory (FADDL), APHIS, USDA, Plum Island Animal Disease Center (PIADC), Greenport, NY, USA.
authors.forename: Consuelo
authors.initials: C
authors.lastname: Carrillo
authors.affiliation: Agencia Ecuatoriana de Aseguramiento de Calidad del Agro - AGROCALIDAD, Av. Interoceánica km. 14½, La Granja MAGAP, Tumbaco, Ecuador.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Burbano
authors.affiliation: Agencia Ecuatoriana de Aseguramiento de Calidad del Agro - AGROCALIDAD, Av. Interoceánica km. 14½, La Granja MAGAP, Tumbaco, Ecuador.
authors.forename: Javier
authors.initials: J
authors.lastname: Vargas
authors.affiliation: Foreign Animal Disease Diagnostic Laboratory (FADDL), APHIS, USDA, Plum Island Animal Disease Center (PIADC), Greenport, NY, USA.
authors.forename: Lisa
authors.initials: L
authors.lastname: Pauszek
authors.affiliation: Foreign Animal Disease Diagnostic Laboratory (FADDL), APHIS, USDA, Plum Island Animal Disease Center (PIADC), Greenport, NY, USA.
authors.forename: Ian
authors.initials: I
authors.lastname: Olesen
authors.affiliation: Pan-American Foot-and-Mouth Disease Center - PANAFTOSA/PAHO, Av. Governador Leonel de Moura Brizola 7778, Duque de Caxias, RJ CEP 25045-002, Brazil.
authors.forename: Manuel J
authors.initials: MJ
authors.lastname: Sanchez-Vazquez
authors.affiliation: Pan-American Foot-and-Mouth Disease Center - PANAFTOSA/PAHO, Av. Governador Leonel de Moura Brizola 7778, Duque de Caxias, RJ CEP 25045-002, Brazil.
authors.forename: Ottorino
authors.initials: O
authors.lastname: Cosivi
authors.affiliation: Pan-American Foot-and-Mouth Disease Center - PANAFTOSA/PAHO, Av. Governador Leonel de Moura Brizola 7778, Duque de Caxias, RJ CEP 25045-002, Brazil. Electronic address: rallende@paho.org.
authors.forename: Rossana M
authors.initials: RM
authors.lastname: Allende
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D036022:Capsid Proteins / Q000235:genetics; D002417:Cattle; D002418:Cattle Diseases / Q000517:prevention & control* / Q000821:virology; D056738:Cross Protection; D004484:Ecuador; D005536:Foot-and-Mouth Disease / Q000517:prevention & control*; D029544:Foot-and-Mouth Disease Virus / Q000145:classification; D014611:Vaccination / Q000662:veterinary; D014765:Viral Vaccines / Q000276:immunology / Q000627:therapeutic use*
chemical_list: D000914:Antibodies, Viral; D036022:Capsid Proteins; C442501:VP1 protein, Foot-and-mouth disease virus; D014765:Viral Vaccines
keywords: Disease control; Expectancy of protection; Foot-and-Mouth Disease; Vaccination; Vaccine matching