title: Polymorphisms in complement genes and risk of preeclampsia in Taiyuan, China.
abstract: OBJECTIVE
  Altered immune response may be a part of the pathogenesis of preeclampsia. The few epidemiologic studies that have investigated the associations between genetic variations in the complement system genes and preeclampsia risk have reached inconsistent results. The aim of this study is to determine if polymorphisms in the complement system genes could influence the risk of preeclampsia.
  
  
  METHODS
  We examined 51 SNPs in the C3, C5, C6, MASP1, MBL2 and CD55 genes and the risk of preeclampsia and its clinical subtypes in a nested case-control study of 203 preeclampsia cases and 233 controls.
  
  
  RESULTS
  Both C6 and MASP1 were associated with the risk of preeclampsia. C6 (rs7444800, rs4957381) and MASP1 (rs1108450, rs3774282, rs698106) polymorphisms were associated with the risk of early-onset preeclampsia and severe preeclampsia, while MASP1 (rs1357134, rs698090) polymorphisms were associated with the risk of late-onset preeclampsia and severe preeclampsia.
  
  
  CONCLUSIONS
  Our study provided novel evidence that genetic variations in complement genes C6 and MASP1were associated with preeclampsia risk, and that the risk varied by preeclampsia subtypes.
authors.affiliation: Department of Epidemiology, Shanxi Medical University School of Public Health, 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Wu
authors.affiliation: Department of Obstetrics, the First Affiliated Hospital, Shanxi Medical University, Taiyuan, China.
authors.forename: Hailan
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Epidemiology, Shanxi Medical University School of Public Health, 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China.
authors.forename: Yongliang
authors.initials: Y
authors.lastname: Feng
authors.affiliation: Department of Epidemiology, Shanxi Medical University School of Public Health, 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Information, the First Affiliated Hospital, Shanxi Medical University, Taiyuan, China.
authors.forename: Shuzhen
authors.initials: S
authors.lastname: Li
authors.affiliation: Center for Disease Control and Prevention, Taiyuan Railway Administration, Taiyuan, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Epidemiology, Shanxi Medical University School of Public Health, 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Peng
authors.affiliation: Department of Epidemiology, Shanxi Medical University School of Public Health, 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Epidemiology, Shanxi Medical University School of Public Health, 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China.
authors.forename: Bingjie
authors.initials: B
authors.lastname: Xie
authors.affiliation: Department of Epidemiology, Shanxi Medical University School of Public Health, 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China.
authors.forename: Pengge
authors.initials: P
authors.lastname: Guo
authors.affiliation: Department of Epidemiology, Shanxi Medical University School of Public Health, 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Epidemiology, Shanxi Medical University School of Public Health, 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Environmental Health Sciences, Yale School of Public Health, 60 College Street, New Haven, CT, 06520, USA.
authors.forename: Nan
authors.initials: N
authors.lastname: Zhao
authors.affiliation: Department of Environmental Health Sciences, Yale School of Public Health, 60 College Street, New Haven, CT, 06520, USA.
authors.forename: Dennis
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Epidemiology, Shanxi Medical University School of Public Health, 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China. spwang88@163.com.
authors.forename: Suping
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Epidemiology, Shanxi Medical University School of Public Health, 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China. yawei.zhang@yale.edu.|Department of Environmental Health Sciences, Yale School of Public Health, 60 College Street, New Haven, CT, 06520, USA. yawei.zhang@yale.edu.
authors.forename: Yawei
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D003165:Complement System Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000453:epidemiology / Q000235:genetics*; D011247:Pregnancy; D012306:Risk
chemical_list: D003165:Complement System Proteins
keywords: C6; Complement genes; Epidemiology; Genetic polymorphism; MASP1; Preeclampsia