title: Reemergence of Chloramphenicol Sensitivity in Enteric Fever.
abstract: BACKGROUND
  Enteric fever is a global health problem and rapidly developing resistance to various drugs makes the situation more alarming. Drug sensitivity in Salmonella enterica serovar typhi and Salmonella enterica serovar paratyphi A isolated from 45 blood culture positive cases of enteric fever was tested to determine in-vitro susceptibility pattern of prevalent strains in northern India.
  
  
  METHODS
  Strains isolated from 45 blood culture positive cases of typhoid and paratyphoid fever over a period of three years were studied and their sensitivity patterns to chloramphenicol, ampicillin, ciprofloxacin, ceftriaxone, nalidixic acid, amikacin and ofloxacin were analysed.
  
  
  RESULTS
  Our results show a high sensitivity of both Salmonella enterica serovar typhi (96%) and Salmonella enterica serovar paratyphi A (100%) to chloramphenicol. Sensitivity to ciprofloxacin and amikacin was 88% and 84% respectively. All the isolates were sensitive to ofloxacin, nalidixic acid and ceftriaxone. Sensitivity of Salmonella enterica serovar paratyphi A was 100% to chloramphenicol, ciprofloxacin, ofloxacin, nalidixic acid and ceftriaxone, 95% to amikacin and 30% to ampicillin. Overall 44 out of 45 isolates of Salmonellae were sensitive to chloramphenicol.
  
  
  CONCLUSIONS
  These findings suggest changing pattern of antibiotic resistance in enteric fever with reemergence of chloramphenicol sensitivity in northern India.
authors.affiliation: Graded Specialist (Pathology), Military Hospital, Mathura.
authors.forename: J K
authors.initials: JK
authors.lastname: Bhatia
authors.affiliation: Senior Advisor (Medicine), Base Hospital Delhi Cantt.
authors.forename: A D
authors.initials: AD
authors.lastname: Mathur
authors.affiliation: Professor and Head (Biochemistry), Armed Forces Medical College, Pune-40.
authors.forename: M M
authors.initials: MM
authors.lastname: Arora
keywords: Chloramphenicol; Enteric fever; Salmonella enterica serovar paratyphi A; Salmonella enterica serovar typhi