title: Total oxidant status, total antioxidant capacity and ischemia modified albumin levels in children with celiac disease.
abstract: In our study, we aimed to investigate ischemia modified albumin (IMA) as an oxidative stress marker, as well as other oxidant and antioxidant markers that have not been evaluated in children with celiac disease. A total of 37 pediatric patients who were diagnosed with celiac disease (CD) and 29 healthy children were enrolled in this prospective study. We evaluated the IMA, total oxidant status, total antioxidant capacity, sulfhydryl, and advanced oxidation protein products in all of the subjects. We also compared the levels at the time of the diagnosis, and following a gluten-free diet (GFD) in the children with CD. While the IMA and the other oxidant marker levels were significantly higher in the patient group compared to the control group, the antioxidant marker levels were found to be significantly lower in the patient group, compared to the control group. We also determined that the tissue transglutaminase IgA showed a highly positive correlation, and that the IMA showed a moderately positive correlation with the Marsh-Oberhuber histopathological stage. Additionally, the IMA and other oxidant marker levels were significantly lower, while the antioxidant marker levels were significantly higher after the GFD, compared to the pre-diet period. We detected that oxidative stress played a role in the pathogenesis of CD, and that this could be evaluated using oxidative stress markers, which would regress after the GFD. We also detected that IMA is a marker that shows a correlation with the histopathological stage, and may be used in the diagnosis.
authors.affiliation: Department of Pediatric Gastroenterology, Konya Training and Research Hospital, Konya, Turkey. ersinsayar@hotmail.com.
authors.forename: Ersin
authors.initials: E
authors.lastname: Sayar
authors.forename: Sebahat
authors.initials: S
authors.lastname: Özdem
authors.forename: Gülbahar
authors.initials: G
authors.lastname: Uzun
authors.forename: Ali
authors.initials: A
authors.lastname: İşlek
authors.forename: Aygen
authors.initials: A
authors.lastname: Yılmaz
authors.forename: Reha
authors.initials: R
authors.lastname: Artan
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D002446:Celiac Disease / Q000378:metabolism*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D016877:Oxidants / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology*; D011446:Prospective Studies; D012709:Serum Albumin; D000075462:Serum Albumin, Human
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D016877:Oxidants; D012709:Serum Albumin; C561522:ischemia-modified albumin; D000075462:Serum Albumin, Human