title: Effect of intercalator and Lewis acid-base branched peptide complex formation: boosting affinity towards HIV-1 RRE RNA.
abstract: High throughput screening of a 4096 compound library of boronic acid and acridine containing branched peptides revealed compounds that have dissociation constants in the low nanomolar regime for HIV-1 RRE IIB RNA. We demonstrate that branched peptide boronic acidsA5,A6, andA7inhibit the production of p24, an HIV-1 capsid protein, in a dose-dependent manner.
authors.affiliation: Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, VA 24060, USA.
authors.forename: Jessica E
authors.initials: JE
authors.lastname: Wynn
authors.affiliation: Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, VA 24060, USA.
authors.forename: Wenyu
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Microbiology, Myles H. Thaler Center for AIDS and Human Retrovirus Research, University of Virginia, Charlottesville, VA 22904, USA.
authors.forename: Denis M
authors.initials: DM
authors.lastname: Tebit
authors.affiliation: Department of Microbiology, Myles H. Thaler Center for AIDS and Human Retrovirus Research, University of Virginia, Charlottesville, VA 22904, USA.
authors.forename: Laurie R
authors.initials: LR
authors.lastname: Gray
authors.affiliation: Department of Microbiology, Myles H. Thaler Center for AIDS and Human Retrovirus Research, University of Virginia, Charlottesville, VA 22904, USA.
authors.forename: Marie-Louise
authors.initials: ML
authors.lastname: Hammarskjold
authors.affiliation: Department of Microbiology, Myles H. Thaler Center for AIDS and Human Retrovirus Research, University of Virginia, Charlottesville, VA 22904, USA.
authors.forename: David
authors.initials: D
authors.lastname: Rekosh
authors.affiliation: Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, VA 24060, USA.
authors.forename: Webster L
authors.initials: WL
authors.lastname: Santos