title: A Rare Case of Florid Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis Involving Both Atrioventricular Valves.
abstract: Cardiac involvement is rare in antineutrophil cytoplasmic autoantibody (ANCA)-associated systemic vasculitis but can involve aortic and mitral valves. We present an unusual case of a 65-year-old woman who presented 16 years after an aortic valve replacement with severe mitral regurgitation with ACNA-associated vasculitis. The extensive nature of the pathologic condition, which extended to the tricuspid valve, prevented the replacement of the mitral valve during a surgical procedure. This is a rare case in which florid valvulopathy was observed in association with vasculitis.
authors.affiliation: Department of Cardiothoracic Surgery, King's College Hospital, Denmark Hill, London, United Kingdom. Electronic address: hkhan76@hotmail.com.
authors.forename: Habib
authors.initials: H
authors.lastname: Khan
authors.affiliation: Department of Cardiothoracic Surgery, King's College Hospital, Denmark Hill, London, United Kingdom.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Chaubey
authors.affiliation: Department of Cardiothoracic Surgery, King's College Hospital, Denmark Hill, London, United Kingdom.
authors.forename: Rynda
authors.initials: R
authors.lastname: Nitiahpapand
authors.affiliation: Department of Cardiothoracic Surgery, King's College Hospital, Denmark Hill, London, United Kingdom.
authors.forename: Jatin
authors.initials: J
authors.lastname: Desai
mesh_terms: D000368:Aged; D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D001022:Aortic Valve Insufficiency / Q000000981:diagnostic imaging / Q000276:immunology / Q000601:surgery; D001707:Biopsy, Needle; D003520:Cyclophosphamide / Q000008:administration & dosage; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000627:therapeutic use; D006333:Heart Failure / Q000175:diagnosis / Q000209:etiology; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006801:Humans; D007150:Immunohistochemistry; D008943:Mitral Valve / Q000473:pathology*; D008944:Mitral Valve Insufficiency / Q000000981:diagnostic imaging / Q000276:immunology / Q000601:surgery*; D035583:Rare Diseases; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D003520:Cyclophosphamide