title: Overexpression of p42.3 promotes cell proliferation, migration, and invasion in human gastric cancer cells.
abstract: As a newly discovered tumor-specific gene, p42.3 is overexpressed in most of human gastric cancers (GC). However, the role of p42.3 in GC progression remains unclear. To assess the role of p42.3 in gastric cancers, immunohistochemistry and western blot were performed to detect the p42.3 expression in human GC tissues and cells. We also investigated the role of p42.3 in GC cell proliferation, migration, and invasion. Our results showed that the p42.3 expression was increased dramatically in human GC tissue and cells. In addition, we found that overexpression of p42.3 promotes GC cell proliferation, migration, and invasion abilities. Furthermore, p42.3 expression suppressed the E-cadherin protein level and promoted the β-catenin and p-ERK protein level. Taken together, overexpressed p42.3 is correlated with gastric cancer cell proliferation, migration, and invasion, suggesting its use as a biological marker in gastric cancer.
authors.affiliation: Jiangsu Key Laboratory of Biological Cancer Therapy, Xuzhou Medical College, Xuzhou, China.|Affiliated Hospital of Shandong Academy of Medical Sciences, Jinan, China.
authors.forename: Wen-Jia
authors.initials: WJ
authors.lastname: Cao
authors.affiliation: Jiangsu Key Laboratory of Biological Cancer Therapy, Xuzhou Medical College, Xuzhou, China.
authors.forename: Wen-Qi
authors.initials: WQ
authors.lastname: Du
authors.affiliation: Jiangsu Key Laboratory of Biological Cancer Therapy, Xuzhou Medical College, Xuzhou, China.
authors.forename: Lin-Lin
authors.initials: LL
authors.lastname: Mao
authors.affiliation: Jiangsu Key Laboratory of Biological Cancer Therapy, Xuzhou Medical College, Xuzhou, China. jnzheng@xzmc.edu.cn.|Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Xuzhou Medical College, Xuzhou, 221002, China. jnzheng@xzmc.edu.cn.|Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical College, Xuzhou, 221002, China. jnzheng@xzmc.edu.cn.
authors.forename: Jun-Nian
authors.initials: JN
authors.lastname: Zheng
authors.affiliation: Jiangsu Key Laboratory of Biological Cancer Therapy, Xuzhou Medical College, Xuzhou, China. dspei@xzmc.edu.cn.|Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Xuzhou Medical College, Xuzhou, 221002, China. dspei@xzmc.edu.cn.|Department of Pathology, Xuzhou Medical College, 209 Tong-shan Road, Xuzhou, Jiangsu, China. dspei@xzmc.edu.cn.
authors.forename: Dong-Sheng
authors.initials: DS
authors.lastname: Pei
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D015153:Blotting, Western; D015820:Cadherins / Q000378:metabolism; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism*; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D009361:Neoplasm Invasiveness; D009687:Nuclear Proteins; D034622:RNA Interference; D013274:Stomach Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D015854:Up-Regulation; D051176:beta Catenin / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D015820:Cadherins; D018797:Cell Cycle Proteins; D009687:Nuclear Proteins; C000607889:SAPCD2 protein, human; D051176:beta Catenin; D048049:Extracellular Signal-Regulated MAP Kinases
keywords: E-cadherin; ERK; Invasion; Proliferation; p42.3; β-catenin