title: Assessing Tumor Response to Treatment in Patients with Lung Cancer Using Dynamic Contrast-Enhanced CT.
abstract: The aim of this study was to provide an overview of the literature available on dynamic contrast-enhanced computed tomography (DCE-CT) as a tool to evaluate treatment response in patients with lung cancer. This systematic review was compiled according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Only original research articles concerning treatment response in patients with lung cancer assessed with DCE-CT were included. To assess the validity of each study we implemented Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2). The initial search yielded 651 publications, and 16 articles were included in this study. The articles were divided into groups of treatment. In studies where patients were treated with systemic chemotherapy with or without anti-angiogenic drugs, four out of the seven studies found a significant decrease in permeability after treatment. Four out of five studies that measured blood flow post anti-angiogenic treatments found that blood flow was significantly decreased. DCE-CT may be a useful tool in assessing treatment response in patients with lung cancer. It seems that particularly permeability and blood flow are important perfusion values for predicting treatment outcome. However, the heterogeneity in scan protocols, scan parameters, and time between scans makes it difficult to compare the included studies.
authors.affiliation: Department of Diagnostic Radiology, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark. louisesoeborg9@gmail.com.|Department of Technology, Faculty of Health and Technology, Metropolitan University College, 2200 Copenhagen, Denmark. louisesoeborg9@gmail.com.
authors.forename: Louise S
authors.initials: LS
authors.lastname: Strauch
authors.affiliation: Department of Diagnostic Radiology, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark. roestbjerge@gmail.com.|Department of Technology, Faculty of Health and Technology, Metropolitan University College, 2200 Copenhagen, Denmark. roestbjerge@gmail.com.
authors.forename: Rie Ø
authors.initials: RØ
authors.lastname: Eriksen
authors.affiliation: Department of Diagnostic Radiology, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark. michael@sandgaard.org.
authors.forename: Michael
authors.initials: M
authors.lastname: Sandgaard
authors.affiliation: Department of Diagnostic Radiology, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark. tskaarup@yahoo.com.
authors.forename: Thomas S
authors.initials: TS
authors.lastname: Kristensen
authors.affiliation: Department of Diagnostic Radiology, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark. mbn@dadlnet.dk.
authors.forename: Michael B
authors.initials: MB
authors.lastname: Nielsen
authors.affiliation: Department of Diagnostic Radiology, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark. cala@phmetropol.dk.|Department of Technology, Faculty of Health and Technology, Metropolitan University College, 2200 Copenhagen, Denmark. cala@phmetropol.dk.
authors.forename: Carsten A
authors.initials: CA
authors.lastname: Lauridsen
keywords: DCE-CT; Dynamic Contrast-Enhanced CT; lung cancer; treatment response