title: Two infants with tuberculid associated with Kawasaki disease.
abstract: Bacille de Calmette et Guerin (BCG) is the only licensed tuberculosis vaccine to prevent severe tuberculosis. The adverse events of BCG vaccination, including local reactions, lymphadenitis, osteomyelitis, tuberculid, and disseminated infection, have been reported. Two infants presented erythema at the inoculation site of BCG after the resolution of Kawasaki disease (KD). They received BCG vaccination 1 week and 6 weeks before the KDonset, respectively. Intravenous immunoglobulin improved the KDactivity, however the skin rash of BCG inoculation site extended to the face and extremities days 24 and 10 after the KDonset, respectively. Both bacteriological study and interferon-γ release assay were negative for Mycobacterium tuberculosis infection. These patients were diagnosed as having tuberculid after KD. The skin lesions gradually disappeared without antibiotic therapy over 2 months. The development of tuberculid in these patients might be associated with the remnant immune activation of KD.
authors.affiliation: a Department of Pediatrics , Yamaguchi University Graduate School of Medicine , Ube , Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Yamada
authors.affiliation: a Department of Pediatrics , Yamaguchi University Graduate School of Medicine , Ube , Japan.
authors.forename: Haruka
authors.initials: H
authors.lastname: Ohta
authors.affiliation: a Department of Pediatrics , Yamaguchi University Graduate School of Medicine , Ube , Japan.
authors.forename: Shunji
authors.initials: S
authors.lastname: Hasegawa
authors.affiliation: a Department of Pediatrics , Yamaguchi University Graduate School of Medicine , Ube , Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Azuma
authors.affiliation: b Division of Pediatrics , Yamaguchi Grand Medical Center , Hofu , Japan.
authors.forename: Masanari
authors.initials: M
authors.lastname: Hasegawa
authors.affiliation: c Division of Pediatrics , Yamaguchi Red Cross Hospital , Yamaguchi , Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Kadoya
authors.affiliation: c Division of Pediatrics , Yamaguchi Red Cross Hospital , Yamaguchi , Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Ohbuchi
authors.affiliation: a Department of Pediatrics , Yamaguchi University Graduate School of Medicine , Ube , Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ohnishi
authors.affiliation: a Department of Pediatrics , Yamaguchi University Graduate School of Medicine , Ube , Japan.
authors.forename: Seigo
authors.initials: S
authors.lastname: Okada
authors.affiliation: a Department of Pediatrics , Yamaguchi University Graduate School of Medicine , Ube , Japan.
authors.forename: Madoka
authors.initials: M
authors.lastname: Hoshide
authors.affiliation: a Department of Pediatrics , Yamaguchi University Graduate School of Medicine , Ube , Japan.
authors.forename: Shouichi
authors.initials: S
authors.lastname: Ohga
mesh_terms: D001500:BCG Vaccine / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications*; D014382:Tuberculosis, Cutaneous / Q000175:diagnosis* / Q000473:pathology*
chemical_list: D001500:BCG Vaccine
keywords: Bacille de Calmette et Guerin (BCG); Kawasaki disease; children; tuberculid; vaccination