title: Effects of anaesthesia on paediatric lung function.
abstract: Respiratory adverse events are one of the major causes of morbidity and mortality in paediatric anaesthesia. Aside from predisposing conditions associated with an increased risk of respiratory incidents in children such as concurrent infections and chronic airway irritation, there are adverse respiratory events directly attributable to the impact of anaesthesia on the respiratory system. Anaesthesia can negatively affect respiratory drive, ventilation/perfusion (V/Q) matching and tidal breathing, all resulting in potentially devastating hypoxaemia. Understanding paediatric respiratory physiology and its changes during anaesthesia will enable anaesthetists to anticipate, recognize and prevent deterioration that can lead to respiratory failure. This review aims to give a comprehensive overview of the effects of anaesthesia on respiration in children. It focuses on the impact of the different components of anaesthesia, patient positioning and procedure-related changes on respiratory physiology.
authors.affiliation: Division of Paediatric Intensive Care and Pulmonology, University of Basel Children's Hospital UKBB, Switzerland.
authors.forename: D
authors.initials: D
authors.lastname: Trachsel
authors.affiliation: Department of Anaesthesia and Pain Management, Fiona Stanley Hospital, Perth, Australia.
authors.forename: J
authors.initials: J
authors.lastname: Svendsen
authors.affiliation: Division of Paediatric Anaesthesia, University of Basel Children's Hospital UKBB, Switzerland.
authors.forename: T O
authors.initials: TO
authors.lastname: Erb
authors.affiliation: Department of Anaesthesia and Pain Management, Princess Margaret Hospital for Children, Perth, Australia School of Medicine and Pharmacology, University of Western Australia britta.regli-vonungern@health.wa.gov.au.
authors.forename: B S
authors.initials: BS
authors.lastname: von Ungern-Sternberg
mesh_terms: D000758:Anesthesia; D000776:Anesthesiology; D002648:Child; D006801:Humans; D012119:Respiration; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency
keywords: anaesthesia; anaesthetic agents; child; lung fuction; lung volumes; paediatric; respiratory system; ventilation