title: Methicillin-Resistant Staphylococcus aureus Nasal Colonization in Chinese Children: A Prevalence Meta-Analysis and Review of Influencing Factors.
abstract: OBJECTIVE
  To determine the pooled prevalence and review the influencing factors of methicillin-resistant Staphylococcus aureus (MRSA) nasal colonization in Chinese children.
  
  
  METHODS
  Articles published between January 2005 and October 2015 that studied prevalence or influencing factors of MRSA nasal colonization in Chinese children were retrieved from Chinese Biomedical Literature database (CBM), China National Knowledge Infrastructure (CNKI) database, Chinese VIP database, Chinese Wanfang database, Medline database and Ovid database. Prevalence and influencing factors were analyzed by STATA 13.1.
  
  
  RESULTS
  Thirteen articles were included. The overall prevalence of MRSA nasal colonization was 4.4% (95% confidence interval [CI]: 0.027-0.062). With an MRSA prevalence of 3.9% (95% CI: 0.018-0.061) in healthy children and 5.8% (95% CI: 0.025-0.092) in children with underlying medical conditions. Children recruited in the hospitals presented MRSA prevalence of 6.4% (95% CI: 0.037-0.091), which was higher than those recruited in the communities [2.7% (95% CI: 0.012-0.043)]. A number of influencing factors for MRSA nasal colonization were noted in three eligible studies: gender (male vs female; OR: 0.67; 95% CI: 0.55-0.82), younger age (OR: 2.98; 95% CI: 1.31-6.96 and OR: 1.56; 95% CI: 1.21-2.00), attending day care centers (OR: 2.97; 95% CI: 1.28-6.76), having infectious diseases (OR: 2.31; 95% CI: 1.10-4.52), using antibiotics (OR: 2.77; 95% CI: 1.45-5.05), residing in northern Taiwan (OR: 1.41; 95% CI: 1.15-1.71), passive smoking (OR: 1.30; 95% CI: 1.02-1.63), and pneumococcal vaccination (OR: 1.22; 95% CI: 1.01-1.48).
  
  
  CONCLUSIONS
  Children could act as reservoirs of MRSA transmissions. Hospitals remained the most frequent microorganism-circulated settings. More MRSA infection control strategies are required to prevent the dissemination among children.
authors.affiliation: Department of Epidemiology and Health Statistics, Guangdong Pharmaceutical University, Guangzhou, China.
authors.forename: Jialing
authors.initials: J
authors.lastname: Lin
authors.affiliation: Centre for Chronic Disease, University of Queensland, Brisbane, Australia.
authors.forename: Yang
authors.initials: Y
authors.lastname: Peng
authors.affiliation: Department of Epidemiology and Health Statistics, Guangdong Pharmaceutical University, Guangzhou, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Xu
authors.affiliation: Department of Epidemiology and Health Statistics, Guangdong Pharmaceutical University, Guangzhou, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology and Health Statistics, Guangdong Pharmaceutical University, Guangzhou, China.
authors.forename: Chan
authors.initials: C
authors.lastname: Bai
authors.affiliation: Department of Epidemiology and Health Statistics, Guangdong Pharmaceutical University, Guangzhou, China.
authors.forename: Dongxin
authors.initials: D
authors.lastname: Lin
authors.affiliation: Department of Epidemiology and Health Statistics, Guangdong Pharmaceutical University, Guangzhou, China.
authors.forename: Qianting
authors.initials: Q
authors.lastname: Ou
authors.affiliation: Department of Epidemiology and Health Statistics, Guangdong Pharmaceutical University, Guangzhou, China.
authors.forename: Zhenjiang
authors.initials: Z
authors.lastname: Yao
mesh_terms: D000367:Age Factors; D002353:Carrier State / Q000453:epidemiology*; D002648:Child; D016208:Databases, Factual; D005260:Female; D006801:Humans; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000302:isolation & purification; D009297:Nasal Mucosa / Q000382:microbiology*; D016017:Odds Ratio; D011159:Population Surveillance; D015995:Prevalence; D017594:Publication Bias; D013203:Staphylococcal Infections / Q000453:epidemiology* / Q000382:microbiology*