title: Inflammation and positive affect: Examining the stress-buffering hypothesis with data from the National Longitudinal Study of Adolescent to Adult Health.
abstract: The present study examined the influence of positive affect (PA) on levels of inflammation within the context of Pressman and Cohen's (2005) stress-buffering model, which suggests that PA confers protective health benefits through its ability to mitigate the pathogenic influence of stress. We hypothesized that greater PA would buffer against the influence of perceived psychological stress (PPS) on systemic inflammation, operationalized as C-reactive protein (CRP, mg/L). Specifically, we predicted that PA would moderate the relationship between PPS and CRP. Cross-sectional data were drawn from Wave IV (2008-2009) of the National Longitudinal Study of Adolescent to Adult Health (Add Health). Participants (n=3093) ranged in age from 25 to 34years old (M=29.0±1.79). Using a moderated hierarchical regression analysis, PPS and PA significantly interacted to predict levels of CRP (p<0.05). Examination of the simple slopes revealed a disordinal interaction between PPS and PA, such that higher PA was protective against elevated CRP levels, but only when individuals also reported greater levels of PPS. Thus, the data partially support the stress-buffering model of PA and extend existing evidence regarding the complexity by which PPS and PA influence health. Findings also provide caution of future assumptions that relationships among PA, PPS, and physical health markers, such as CRP, are always positive (e.g., PA) or negative (e.g., PPS) in nature.
authors.affiliation: Health Psychology Graduate Program, The University of North Carolina at Charlotte, USA.
authors.forename: Cara L
authors.initials: CL
authors.lastname: Blevins
authors.affiliation: Health Psychology Graduate Program, The University of North Carolina at Charlotte, USA.
authors.forename: Sara J
authors.initials: SJ
authors.lastname: Sagui
authors.affiliation: Health Psychology Graduate Program, The University of North Carolina at Charlotte, USA; Department of Psychology, The University of North Carolina at Charlotte, USA. Electronic address: jeanette.bennett@uncc.edu.
authors.forename: Jeanette M
authors.initials: JM
authors.lastname: Bennett
mesh_terms: D000328:Adult; D000339:Affect / Q000502:physiology*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000523:psychology*; D008137:Longitudinal Studies; D008297:Male; D013315:Stress, Psychological / Q000097:blood / Q000523:psychology*
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein
keywords: Inflammation; Perceived psychological stress; Positive affect; Stress protective; Young adulthood