title: Topical Mitomycin C application in the treatment of refractory benign esophageal strictures in adults and comprehensive literature review.
abstract: BACKGROUND
  Recurrent complex esophageal strictures remain difficult to manage.
  
  
  OBJECTIVE
  To determine the efficacy of topical Mitomycin C application for recurrent benign esophageal strictures.
  
  
  METHODS
  All patients who underwent balloon dilation followed by topical Mitomycin C application for recurrent benign esophageal strictures were included. Primary outcome was number of dilations and change of dysphagia score.
  
  
  RESULTS
  Nine patients with anastomotic (3), radiation-induced (3), caustic (2), and combined anastomotic and radiation-induced (1) strictures were included. Strictures had a mean length of 13.75mm, diameter of 8.0mm, and were dilated 10.7 times over a median of 8 months (1.5 dilations per month). Following Mitomycin C application, the need for further dilation decreased to 0.39 dilations per month over a median of 10 months; however, dysphagia scores improved not significantly from 3.2 to 2.6 (mean).
  
  
  CONCLUSIONS
  In this pilot study, topical Mitomycin C in conjunction with dilation decreased the frequency of esophageal dilations for recurrent benign esophageal strictures.
authors.affiliation: Gastroentrology and Hepatology, Mayo Clinic, Jacksonville, FL, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Bartel
authors.affiliation: General Internal Medicine, Mayo Clinic, Jacksonville, FL, USA.
authors.forename: Kristina
authors.initials: K
authors.lastname: Seeger
authors.affiliation: General Internal Medicine, Mayo Clinic, Jacksonville, FL, USA.
authors.forename: Kayin
authors.initials: K
authors.lastname: Jeffers
authors.affiliation: General Internal Medicine, Mayo Clinic, Jacksonville, FL, USA.
authors.forename: Donnesha
authors.initials: D
authors.lastname: Clayton
authors.affiliation: Gastroentrology and Hepatology, Mayo Clinic, Jacksonville, FL, USA.
authors.forename: Michael B
authors.initials: MB
authors.lastname: Wallace
authors.affiliation: Gastroentrology and Hepatology, Mayo Clinic, Jacksonville, FL, USA.
authors.forename: Massimo
authors.initials: M
authors.lastname: Raimondo
authors.affiliation: Gastroentrology and Hepatology, Mayo Clinic, Jacksonville, FL, USA. Electronic address: Woodward.timothy@mayo.edu.
authors.forename: Timothy A
authors.initials: TA
authors.lastname: Woodward
mesh_terms: D000368:Aged; D000477:Alkylating Agents / Q000008:administration & dosage*; D000714:Anastomosis, Surgical / Q000009:adverse effects; D021721:Balloon Occlusion; D002424:Caustics / Q000627:therapeutic use; D003251:Constriction, Pathologic / Q000209:etiology; D003680:Deglutition Disorders / Q000209:etiology; D004938:Esophageal Neoplasms / Q000601:surgery; D004940:Esophageal Stenosis / Q000628:therapy*; D004945:Esophagoscopy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage*; D010865:Pilot Projects; D016032:Randomized Controlled Trials as Topic; D012008:Recurrence; D012196:Review Literature as Topic; D016896:Treatment Outcome
chemical_list: D000477:Alkylating Agents; D002424:Caustics; D016685:Mitomycin
keywords: Benign esophageal strictures; Complex; Mitomycin C; Treatment outcome