title: MR/SPECT Imaging Guided Photothermal Therapy of Tumor-Targeting Fe@Fe3O4 Nanoparticles in Vivo with Low Mononuclear Phagocyte Uptake.
abstract: The (125)I-c(RGDyK) peptide PEGylated Fe@Fe3O4 nanoparticles ((125)I-RGD-PEG-MNPs) with the average hydrodynamic diameter of ∼40 nm as a novel multifunctional platform were developed for tumor-targeting MR/SPECT imaging guided photothermal therapy in vivo. On the αvβ3-positive U87MG glioblastoma xenograft model, the signals of tumor from T2-weighted MR and SPECT imaging were much higher than those in the blocking group at 6 h post injection (p.i.) of RGD-PEG-MNPs and (125)I-RGD-PEG-MNPs intravenously, respectively. The pharmacokinetics and biodistribution were analyzed quantitatively by gamma counter ex vivo. The fact suggested that RGD-PEG-MNPs exhibited excellent targeting property and low mononuclear phagocyte uptake. At 6 h p.i. for (125)I-RGD-PEG-MNPs, the maximum uptake of 6.75 ± 1.24% of the percentage injected dose per gram (ID/g) was accumulated in the tumor. At 48 h p.i., only 1.11 ± 0.21% and 0.16 ± 0.09% ID/g were accumulated in the liver and spleen, respectively. With the guidance of MR/SPECT imaging, the multifunctional nanoparticles achieved a good photothermal therapeutic efficacy in vivo.
authors.affiliation: The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University , Shanghai 200234, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University , Shanghai 200234, China.
authors.forename: Heng
authors.initials: H
authors.lastname: Zhao
authors.affiliation: The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University , Shanghai 200234, China.
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University , Shanghai 200234, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhou
authors.affiliation: The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University , Shanghai 200234, China.
authors.forename: Yuping
authors.initials: Y
authors.lastname: Yan
authors.affiliation: Department of Nuclear Medicine, Shanghai Cancer Center & Department of Oncology, Shanghai Medical College, Fudan University , Shanghai 200032, China.
authors.forename: Mingwei
authors.initials: M
authors.lastname: Wang
authors.affiliation: The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University , Shanghai 200234, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Nuclear Medicine, Shanghai Cancer Center & Department of Oncology, Shanghai Medical College, Fudan University , Shanghai 200032, China.
authors.forename: Yingjian
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University , Shanghai 200234, China.
authors.forename: Shiping
authors.initials: S
authors.lastname: Yang
mesh_terms: D005290:Ferric Compounds; D005909:Glioblastoma; D008279:Magnetic Resonance Imaging; D053768:Metal Nanoparticles; D010586:Phagocytes; D014018:Tissue Distribution; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D005290:Ferric Compounds; C000499:ferric oxide
keywords: Fe@Fe3O4 nanoparticles; in vivo; magnetic resonance imaging; single photon emission computed tomography; targeting photothermal therapy