title: Melatonin and Human Cardiovascular Disease.
abstract: The possible therapeutic role of melatonin in the pathophysiology of coronary artery disorder (CAD) is increasingly being recognized. In humans, exogenous melatonin has been shown to decrease nocturnal hypertension, improve systolic and diastolic blood pressure, reduce the pulsatility index in the internal carotid artery, decrease platelet aggregation, and reduce serum catecholamine levels. Low circulating levels of melatonin are reported in individuals with CAD, arterial hypertension, and congestive heart failure. This review assesses current literature on the cardiovascular effects of melatonin in humans. It can be concluded that melatonin deserves to be considered in clinical trials evaluating novel therapeutic interventions for cardiovascular disorders.
authors.affiliation: 1 Department of Medicine, College of Medicine, The University Sleep Disorders Center, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Seithikurippu R
authors.initials: SR
authors.lastname: Pandi-Perumal
authors.affiliation: 1 Department of Medicine, College of Medicine, The University Sleep Disorders Center, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Ahmed S
authors.initials: AS
authors.lastname: BaHammam
authors.affiliation: 2 Division of Health and Behavior, Department of Population Health, New York University Medical Center, Center for Healthful Behavior Change, New York, NY, USA.
authors.forename: Nwakile I
authors.initials: NI
authors.lastname: Ojike
authors.affiliation: 3 Department of Internal Medicine, Icahn School of Medicine at Mount Sinai, Queens Hospital Center, New York, NY, USA.|4 CUNY School of Public Health at Brooklyn College, New York, NY, USA.
authors.forename: Oluwaseun A
authors.initials: OA
authors.lastname: Akinseye
authors.affiliation: 5 Institute for Clinical Evaluative Sciences, Sunnybrook Health Sciences Center, Toronto, Ontario, Canada.
authors.forename: Tetyana
authors.initials: T
authors.lastname: Kendzerska
authors.affiliation: 6 Sleep Disorders Center, Ajax, Ontario, Canada.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Buttoo
authors.affiliation: 7 The Knight Cardiovascular Institute, Oregon Health and Science University, Portland, OR, USA.|8 Department of Medicine, Oregon Health and Science University, Portland, OR, USA.|9 Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR, USA.|10 Centre for Cardiovascular Biology and Disease, Institute for Stem Cell Biology and Regenerative Medicine (inStem), Bangalore, India.
authors.forename: Perundurai S
authors.initials: PS
authors.lastname: Dhandapany
authors.affiliation: 11 Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Gregory M
authors.initials: GM
authors.lastname: Brown
authors.affiliation: 12 BIOMED-UCA-CONICET and Department of Teaching and Research, Faculty of Medical Sciences, Pontificia Universidad Católica Argentina, Buenos Aires, Argentina.
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Cardinali
keywords: blood pressure; cardioprotection; cardiovascular disorders; coronary artery disease; hypertension; melatonin; platelets