title: Is There a Relation between ABO Blood Groups and Clinical Outcome in Patients with Pemphigoid? A Case-Control Study.
abstract: Background. Relationship between blood groups and dermatologic diseases remains controversial and was not yet fully elucidated nor explained clearly. The aim of this study was to examine if any relation exists between different types of pemphigoid diseases and ABO blood group. Methods. In this case-control study, 159 pemphigoid patients and 152 healthy matched-controls were evaluated. All blood group (including Rh status) data for the study was obtained from the hospital medical records. Statistical comparisons were completed with chi-square test and logistic regression. Results. Blood group "O" was found in 32.9% of patients and 38.2% of control group. Blood group "A" was found among 30.8% of patients and 34.2% of control group, while group "B" was reported in 27.4% of cases and 21.1% of controls and "AB" was identified among 8.9% of patients and 6.6% of control group. 84.9% of patients were Rh positive, while in the control group 86.2% of patients were Rh positive. No significant differences were found regarding ABO blood groups (P = 0.46) or Rh (P = 0.76) between pemphigoid patients and control group. Also, older females had the higher risk of developing bullous pemphigoid. Conclusion. We found no relationship between ABO blood groups and pemphigoid disease.
authors.affiliation: Oral Medicine Department, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Sedigheh
authors.initials: S
authors.lastname: Bakhtiari
authors.affiliation: Skin Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Parviz
authors.initials: P
authors.lastname: Toosi
authors.affiliation: Oral Medicine Department, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran; The International Research Collaborative - Oral Health and Equity, School of Anatomy, Physiology and Human Biology, University of Western Australia, Crawley, WA 6009, Australia.
authors.forename: Somayyeh
authors.initials: S
authors.lastname: Azimi
authors.affiliation: Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Nafiseh
authors.initials: N
authors.lastname: Esmaili
authors.affiliation: Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Montazami
authors.affiliation: Department of Oral Medicine, Faculty of Dentistry, Alborz University of Medical Sciences, Karaj, Iran.
authors.forename: Nasrin
authors.identifier: 0000-0002-5697-9401
authors.initials: N
authors.lastname: Rafieian