title: The formate bio-economy.
abstract: In this review we discuss the concept of the formate bio-economy: formate can be produced efficiently from various available resources and can be consumed by microbes as the sole carbon source for the production of value-added chemicals, directly addressing major challenges in energy storage and chemical production. We show that the formate assimilation pathways utilized by natural formatotrophs are either inefficient or are constrained to organisms that are difficult to cultivate and engineer. Instead, adapting model industrial organisms to formatotrophic growth using synthetic, specially tailored formate-assimilation routes could prove an advantageous strategy. Several studies have started to tackle this challenge, but a fully active synthetic pathway has yet to be established, leaving room for future undertakings.
authors.affiliation: Max Planck Institute of Molecular Plant Physiology, Am Mühlenberg 1, 14476 Potsdam-Golm, Germany.
authors.forename: Oren
authors.initials: O
authors.lastname: Yishai
authors.affiliation: Max Planck Institute of Molecular Plant Physiology, Am Mühlenberg 1, 14476 Potsdam-Golm, Germany.
authors.forename: Steffen N
authors.initials: SN
authors.lastname: Lindner
authors.affiliation: Max Planck Institute of Molecular Plant Physiology, Am Mühlenberg 1, 14476 Potsdam-Golm, Germany.
authors.forename: Jorge
authors.initials: J
authors.lastname: Gonzalez de la Cruz
authors.affiliation: Max Planck Institute of Molecular Plant Physiology, Am Mühlenberg 1, 14476 Potsdam-Golm, Germany.
authors.forename: Hezi
authors.initials: H
authors.lastname: Tenenboim
authors.affiliation: Max Planck Institute of Molecular Plant Physiology, Am Mühlenberg 1, 14476 Potsdam-Golm, Germany. Electronic address: Bar-Even@mpimp-golm.mpg.de.
authors.forename: Arren
authors.initials: A
authors.lastname: Bar-Even
mesh_terms: D002245:Carbon Dioxide / Q000378:metabolism; D005561:Formates / Q000737:chemistry* / Q000378:metabolism; D007218:Industrial Microbiology
chemical_list: D005561:Formates; D002245:Carbon Dioxide