title: [HUMAN CYTOMEGALOVIRUS INFECTION AND SPONTANEOUS ABORTION IN PREGNANT WOMEN OF I AND II TRIMESTER].
abstract: The goal of this work was the evaluation of the frequency of human CMV infection among the women, whose pregnancy ended in miscarriage, detection of active forms of infection and treatment before pregnancy. Virological and sero-immunological techniques were used. A total of 116 women who had miscarriages before the 28 week of pregnancy were submitted to the CMV test. 109 women (94.0%) demonstrated positive results. 49 women (42.2%) had active form of the cytomegalovirus infection. 13 women (26.5%) had the recurrent form and 36 patients (73.5%) had the persistent form of CMV infection (stage of productive replication). All the women with active CMVI were treated before the next pregnancy. Immunomodulatory therapy for the treatment was used.
authors.forename: S G
authors.initials: SG
authors.lastname: Cheshik
authors.forename: L B
authors.initials: LB
authors.lastname: Kisteneva
mesh_terms: D000026:Abortion, Habitual / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy / Q000821:virology; D000166:Acridines / Q000627:therapeutic use; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D000956:Antigens, Viral / Q000097:blood*; D002908:Chronic Disease; D003587:Cytomegalovirus / Q000187:drug effects / Q000254:growth & development* / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy / Q000821:virology; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000627:therapeutic use; D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors / Q000627:therapeutic use; D010455:Peptides / Q000627:therapeutic use; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy / Q000821:virology; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D012008:Recurrence; D013949:Thymus Extracts / Q000627:therapeutic use; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000166:Acridines; D000914:Antibodies, Viral; D000956:Antigens, Viral; D007136:Immunoglobulins; D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors; D010455:Peptides; D013949:Thymus Extracts; C045781:cytomegalovirus-specific hyperimmune globulin; C036191:T-activin; C026430:10-carboxymethyl-9-acridanone