title: Aqueous solutions of didecyldimethylammonium chloride and octaethylene glycol monododecyl ether: Toward synergistic formulations against enveloped viruses.
abstract: Micellization of di-n-decyldimethylammonium chloride, [DiC10][Cl], and octaethylene glycol monododecyl ether, C12E8, mixtures have been investigated by surface tension and conductivity measurements. From these results, various physicochemical and thermodynamic key parameters (e.g. micellar mole fraction of [DiC10][Cl], interaction parameter, free energy of micellization, etc.) have been evaluated and discussed in detail. The results prove high synergistic effect between the two surfactants. Based on these results, the virucidal activity of an equimolar mixture of [DiC10][Cl] and C12E8 has been investigated. A marked synergism was observed on lipid-containing deoxyribonucleic and ribonucleic acid viruses, such as herpes virus, respiratory syncytial virus, and vaccinia viruses. In contrast, Coxsackievirus (non-enveloped virus) was not inactivated. These results support that the mechanism is based on the extraction of lipids and/or proteins from the envelope inside the mixed micelles. This extraction creates "holes" the size of which increases with concentration up to a specific value which triggers the virus inactivation. Such a mixture could be used to extend the spectrum of virucidal activity of the amphiphiles virucides commonly employed in numerous disinfectant solutions.
authors.affiliation: Univ. Lille, CNRS, ENSCL, UMR 8181⿿UCCS ⿿ Equipe CÿSCO, F-59000 Lille, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Nardello-Rataj
authors.affiliation: Univ. Lille, CNRS, ENSCL, UMR 8181⿿UCCS ⿿ Equipe CÿSCO, F-59000 Lille, France. Electronic address: loic.leclercq@univ-lille1.fr.
authors.forename: Loïc
authors.initials: L
authors.lastname: Leclercq
mesh_terms: D000818:Animals; D002522:Chlorocebus aethiops; D004305:Dose-Response Relationship, Drug; D004339:Drug Compounding / Q000379:methods*; D004357:Drug Synergism; D056945:Hep G2 Cells; D018259:Herpesvirus 1, Human / Q000187:drug effects / Q000502:physiology; D006801:Humans; D019999:Pharmaceutical Solutions / Q000737:chemistry / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000494:pharmacology; D000644:Quaternary Ammonium Compounds / Q000737:chemistry* / Q000494:pharmacology; D014709:Vero Cells; D014759:Viral Envelope Proteins / Q000037:antagonists & inhibitors* / Q000502:physiology; D014867:Water / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D019999:Pharmaceutical Solutions; D000644:Quaternary Ammonium Compounds; D014759:Viral Envelope Proteins; C585361:di-n-decyldimethylammonium chloride; D014867:Water; C017272:dodecyloctaethyleneglycol monoether; D011092:Polyethylene Glycols
keywords: Binary surfactant systems; Di-n-decyldimethylammonium chloride; Mixed micelles; Octaethylene glycol monododecyl ether; Synergistic formulation; Virus inactivation