title: The impact of FMR1 gene mutations on human reproduction and development: a systematic review.
abstract: OBJECTIVE
  This is a comprehensive review of the literature in this field attempting to put the FMR1 gene and its evaluation into context, both in general and for the reproductive health audience.
  
  
  METHODS
  Online database search of publications with systematic review of all papers relevant to ovarian reserve and assisted reproduction was done.
  
  
  RESULTS
  Relevant papers were identified and assessed, and an attempt was made to understand, rationalize and explain the divergent views in this field of study. Seminal and original illustrations were employed.
  
  
  CONCLUSIONS
  FMR1 is a highly conserved gene whose interpretation and effect on outcomes remains controversial in the reproductive health setting. Recent re-evaluations of the commonly accepted normal range have yielded interesting tools for possibly explaining unexpected outcomes in assisted reproduction. Fragile X investigations should perhaps become more routinely assessed in the reproductive health setting, particularly following a failed treatment cycle where oocyte quality is thought to be a contributing factor, or in the presence of a surprise finding of diminished ovarian reserve in a young patient.
authors.affiliation: Sims Clinic, Clonskeagh, Dublin 14, Ireland.|Sims Clinic, Mahon Point, Cork, Ireland.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Noto
authors.affiliation: Sims Clinic, Clonskeagh, Dublin 14, Ireland.
authors.forename: Conor
authors.initials: C
authors.lastname: Harrity
authors.affiliation: Sims Clinic, Clonskeagh, Dublin 14, Ireland.
authors.forename: David
authors.initials: D
authors.lastname: Walsh
authors.affiliation: Sims Clinic, Clonskeagh, Dublin 14, Ireland. kevin.marron@sims.ie.
authors.forename: Kevin
authors.identifier: http://orcid.org/0000-0003-3537-7281
authors.initials: K
authors.lastname: Marron
mesh_terms: D005260:Female; D051860:Fragile X Messenger Ribonucleoprotein 1 / Q000235:genetics*; D006801:Humans; D009154:Mutation; D065851:Ovarian Reserve / Q000235:genetics*; D012098:Reproduction / Q000235:genetics*; D027724:Reproductive Techniques, Assisted
chemical_list: D051860:Fragile X Messenger Ribonucleoprotein 1; C497683:FMR1 protein, human
keywords: Assisted reproductive technology; FMR1; Fragile X; Genetics; Reproduction; Testing