title: Preparation and Biocompatibility of Gold@ Polypyrrole-Chitosan with Core-Shell Nanostructure.
abstract: A two-step method for preparing Au@polypyrrole-chitosan core-shell nanoparticles (Au @ PPy-CS NPs) was fabricated by in situ polymerization of pyrrole monomer on the surface of Au spheres in chitosan solution. Transmission electron microscopy (TEM) images showed the presence of core-shell structure of nanoparticles. Energy-Dispersive Spectroscopy (EDS) and Fourier transform infrared (FTIR) spectroscopy were adopted to verify the shell is polypyrrole-chitosan. Ultraviolet-visible (UV-vis) and X-ray diffraction (XRD) showed that Au was present in the core-shell nanoparticles. The biocompatibility of Au @ PPy-CS NPs was characterized by in vitro for hemolysis assay and cytotoxicity experiments. Results indicated the Au @ PPy-CS NPs had good blood compatibility and low cytotoxicity. The Au @ PPy-CS NPs we proposed provide a promising platform of blood circulation system for early illness diagnosis and therapy.
authors.forename: Yun
authors.initials: Y
authors.lastname: Wu
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.forename: Shanshan
authors.initials: S
authors.lastname: Ge
authors.forename: Jinling
authors.initials: J
authors.lastname: Zhang
authors.forename: Chun
authors.initials: C
authors.lastname: Mao
authors.forename: Hongyan
authors.initials: H
authors.lastname: Ding
authors.forename: Jian
authors.initials: J
authors.lastname: Shen
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D048271:Chitosan / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures; D011108:Polymers / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*; D011817:Rabbits; D013052:Spectrometry, X-Ray Emission; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D011108:Polymers; D011758:Pyrroles; C067635:polypyrrole; D006046:Gold; D048271:Chitosan