title: Iridoid Glycosides from Tabebuia avellanedae.
abstract: Five novel iridoid glycosides, avellanedaesides A-E (1 - 5) were isolated from the H2O extract of Tabebuia avellanedae. Their structures were determined on the basis of NMR and MS analysis. Isolated compounds suppressed inflammatory cytokine, tumor-necrosis factor-α and interleukin-1β production in cultured human myeloma THP-1 cells co-stimulated with lipopolysaccharide (LPS). In addition, the study revealed iridoid glycosides inhibited the activity of cytochrome CYP3A4 enzyme.
authors.affiliation: Jiyang College of Zhejiang Agriculture and Forestry University, Zhuji, 311800, P. R. China.
authors.forename: Mao-Rong
authors.initials: MR
authors.lastname: Suo
authors.affiliation: Jiyang College of Zhejiang Agriculture and Forestry University, Zhuji, 311800, P. R. China.
authors.forename: Sheng-Ying
authors.initials: SY
authors.lastname: Yan
mesh_terms: D045744:Cell Line, Tumor; D051544:Cytochrome P-450 CYP3A / Q000378:metabolism*; D065692:Cytochrome P-450 CYP3A Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D016207:Cytokines / Q000037:antagonists & inhibitors; D004305:Dose-Response Relationship, Drug; D006801:Humans; D057889:Iridoid Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008968:Molecular Conformation; D013329:Structure-Activity Relationship; D029663:Tabebuia / Q000737:chemistry*
chemical_list: D065692:Cytochrome P-450 CYP3A Inhibitors; D016207:Cytokines; D057889:Iridoid Glycosides; D008070:Lipopolysaccharides; D051544:Cytochrome P-450 CYP3A
keywords: 
  Tabebuia avellanedae
  ; Anti-inflammatory activities; CYP3A4 Enzyme; Iridoids glycosides; THP-1 Cell