title: Development of temporomandibular joint arthritis: The use of animal models.
abstract: Osteoarthritis is the most common joint disease affecting roughly one sixth of the human population. It is also the most common arthritis affecting the temporomandibular joint, often leading to severe pain and the inability to masticate. Animal models are essential to investigate the disease in part because they lend themselves to genetic manipulation and various treatments and also because of the lack of availability of human specimens from various stages of the disease. The wide range of osteoarthritis models alone are a proof of its multifactorial origin. Manipulation of collagen, cytokine, matrix metalloproteinase and small leucine-rich repeat proteoglycan genes can all have an effect on the development and persistence of arthritis. Surgical models also exist, highlighting the importance of normal anatomy and trauma. Here we review the English literature of murine models of temporomandibular joint arthritis with special attention to the genetic and molecular background of osteoarthritis.
authors.affiliation: Oasis Dental Care, Boston, United Kingdom.
authors.forename: Sheida
authors.initials: S
authors.lastname: Ghassemi Nejad
authors.affiliation: Department of trauma and orthopaedic surgery, United Lincolnshire Hospitals NHS Trust, Boston, United Kingdom.
authors.forename: Tamás
authors.initials: T
authors.lastname: Kobezda
authors.affiliation: Department of periodontology, faculty of dentistry, university of Debrecen, Debrecen, Hungary.
authors.forename: Ildikó
authors.initials: I
authors.lastname: Tar
authors.affiliation: Department of medicine, division of rheumatology, faculty of medicine, university of Debrecen, Debrecen, Hungary. Electronic address: szekanecz.zoltan@med.unideb.hu.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Szekanecz
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D010003:Osteoarthritis / Q000209:etiology / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology*; D013704:Temporomandibular Joint / Q000033:anatomy & histology / Q000378:metabolism / Q000503:physiopathology*; D013705:Temporomandibular Joint Disorders / Q000209:etiology / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology*
keywords: Animal models; Arthritis; Murine model; Temporomandibular joint