title: Tuning structural parameters for the optimization of drug delivery performance of cyclodextrin-based nanosponges.
abstract: In light of the recent development of new soft materials, nanostructured self-assembled systems have attracted attention in a variety of technological fields of high social impact. Cyclodextrin nanosponges (CDNS) represent a new and highly versatile class of cross-linked cyclodextrin (CD)-based nanoporous polymers. Their intriguing properties, including safety, biodegradability, negligible toxicity, marked swelling behavior, superior inclusion capability with respect to native CD, are the bases for potential for applications in drug delivery, tissue engineering and regenerative medicine. Areas covered: We report on the state-of-art concerning a detailed characterization of structural and dynamical features of CDNS explored by the combined use of different and complementary techniques, such as Fourier transform infrared absorption in attenuated total reflectance geometry (FTIR-ATR) and Raman spectroscopies, and high resolution magic angle spinning (HR-MAS) NMR spectroscopy. The ambitious objective is to furnish an exhaustive survey of the role played by hydrophobic and hydrophilic groups within the cross-linked network, in dry and swollen states, in determining the macroscopic functional features of CDNS. Expert opinion: The reported results may significantly contribute in the rational design and optimization of new stimuli-responsive systems exhibiting tunable inclusion/release properties, adapted to the therapeutic demands of pathology.
authors.affiliation: a Dipartimento di Scienze Matematiche ed Informatiche, Scienze Fisiche e Scienze della Terra , University of Messina , Messina , Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Venuti
authors.affiliation: b Elettra Sincrotrone Trieste SCpA , Trieste , Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Rossi
authors.affiliation: c Politecnico di Milano Dipartimento di Chimica Materiali e Ingegneria Chimica Giulio Natta - INSTM Local unit , Milano , Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Mele
authors.affiliation: c Politecnico di Milano Dipartimento di Chimica Materiali e Ingegneria Chimica Giulio Natta - INSTM Local unit , Milano , Italy.
authors.forename: Lucio
authors.initials: L
authors.lastname: Melone
authors.affiliation: c Politecnico di Milano Dipartimento di Chimica Materiali e Ingegneria Chimica Giulio Natta - INSTM Local unit , Milano , Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Punta
authors.affiliation: a Dipartimento di Scienze Matematiche ed Informatiche, Scienze Fisiche e Scienze della Terra , University of Messina , Messina , Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Majolino
authors.affiliation: b Elettra Sincrotrone Trieste SCpA , Trieste , Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Masciovecchio
authors.affiliation: d Dipartimento di Chimica , Universita degli Studi di Torino , Torino , Italy.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Caldera
authors.affiliation: d Dipartimento di Chimica , Universita degli Studi di Torino , Torino , Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Trotta
mesh_terms: D003505:Cyclodextrins / Q000737:chemistry*; D016503:Drug Delivery Systems; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D009682:Magnetic Resonance Spectroscopy; D049329:Nanostructures; D017550:Spectroscopy, Fourier Transform Infrared; D013059:Spectrum Analysis, Raman
chemical_list: D003505:Cyclodextrins
keywords: Cyclodextrin nanosponges; FTIR-ATR spectroscopy; HR-MAS NMR spectroscopy; Raman spectroscopy; hydrogel