title: Remote-controlled delivery of CO via photoactive CO-releasing materials on a fiber optical device.
abstract: Although carbon monoxide (CO) delivery materials (CORMAs) have been generated, remote-controlled delivery with light-activated CORMAs at a local site has not been achieved. In this work, a fiber optic-based CO delivery system is described in which the photoactive and water insoluble CO releasing molecule (CORM) manganese(i) tricarbonyl [(OC)3Mn(μ3-SR)]4 (R = nPr, 1) has been non-covalently embedded into poly(l-lactide-co-d/l-lactide) and poly(methyl methacrylate) non-woven fabrics via the electrospinning technique. SEM images of the hybrid materials show a porous fiber morphology for both polymer supports. The polylactide non-woven fabric was attached to a fiber optical device. In combination with a laser irradiation source, remote-controlled and light-triggered CO release at 405 nm excitation wavelength was achieved. The device enabled a high flexibility of the spatially and timely defined application of CO with the biocompatible hybrid fabric in aqueous media. The rates of liberated CO were adjusted with the light intensity of the laser. CO release was confirmed via ATR-IR spectroscopy, a portable electrochemical CO sensor and a heterogeneous myoglobin assay.
authors.affiliation: Institute for Inorganic and Analytical Chemistry (IAAC), Friedrich Schiller University Jena, Humboldtstr. 8, D-07743 Jena, Germany. alexander.schiller@uni-jena.de.
authors.forename: Steve
authors.initials: S
authors.lastname: Gläser
authors.affiliation: Institute for Inorganic and Analytical Chemistry (IAAC), Friedrich Schiller University Jena, Humboldtstr. 8, D-07743 Jena, Germany. alexander.schiller@uni-jena.de.
authors.forename: Ralf
authors.initials: R
authors.lastname: Mede
authors.affiliation: Institute for Inorganic and Analytical Chemistry (IAAC), Friedrich Schiller University Jena, Humboldtstr. 8, D-07743 Jena, Germany. alexander.schiller@uni-jena.de.
authors.forename: Helmar
authors.initials: H
authors.lastname: Görls
authors.affiliation: Institute for Inorganic and Analytical Chemistry (IAAC), Friedrich Schiller University Jena, Humboldtstr. 8, D-07743 Jena, Germany. alexander.schiller@uni-jena.de.
authors.forename: Susanne
authors.initials: S
authors.lastname: Seupel
authors.affiliation: Institute for Inorganic and Analytical Chemistry (IAAC), Friedrich Schiller University Jena, Humboldtstr. 8, D-07743 Jena, Germany. alexander.schiller@uni-jena.de.
authors.forename: Carmen
authors.initials: C
authors.lastname: Bohlender
authors.affiliation: INNOVENT e.V., Biomaterials Department, Pruessingstr. 27 B, D-07745 Jena, Germany.
authors.forename: Ralf
authors.initials: R
authors.lastname: Wyrwa
authors.affiliation: INNOVENT e.V., Biomaterials Department, Pruessingstr. 27 B, D-07745 Jena, Germany.
authors.forename: Sina
authors.initials: S
authors.lastname: Schirmer
authors.affiliation: Leibniz Institute of Photonic Technology, Albert-Einstein-Straße 9, D-07745 Jena, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Dochow
authors.affiliation: Institute for Inorganic and Analytical Chemistry (IAAC), Friedrich Schiller University Jena, Humboldtstr. 8, D-07743 Jena, Germany. alexander.schiller@uni-jena.de.
authors.forename: Gandra Upendar
authors.initials: GU
authors.lastname: Reddy
authors.affiliation: Leibniz Institute of Photonic Technology, Albert-Einstein-Straße 9, D-07745 Jena, Germany and Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich Schiller University Jena, Max-Wien-Platz 1, D-07743 Jena, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Popp
authors.affiliation: Institute for Inorganic and Analytical Chemistry (IAAC), Friedrich Schiller University Jena, Humboldtstr. 8, D-07743 Jena, Germany. alexander.schiller@uni-jena.de.
authors.forename: Matthias
authors.initials: M
authors.lastname: Westerhausen
authors.affiliation: Institute for Inorganic and Analytical Chemistry (IAAC), Friedrich Schiller University Jena, Humboldtstr. 8, D-07743 Jena, Germany. alexander.schiller@uni-jena.de and Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, D-07743 Jena, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Schiller