title: Protective Effect of Salicornia europaea Extracts on High Salt Intake-Induced Vascular Dysfunction and Hypertension.
abstract: High salt intake causes and aggravates arterial hypertension and vascular dysfunction. We investigated the effect of Salicornia europaea extracts (SE) on vascular function and blood pressure. SE constituents were analyzed using high performance liquid chromatography, and SE's effect on vascular function was evaluated in isolated porcine coronary arteries. SE's vascular protective effect was also evaluated in vivo using normotensive and spontaneous hypertensive rats (SHRs). SE mainly contained sodium chloride (55.6%), 5-(hydroxymethyl)furfural, p-coumaric acid, and trans-ferulic acid. High sodium (160 mmol/L) induced vascular dysfunction; however, SE containing the same quantity of sodium did not cause vascular dysfunction. Among the compounds in SE, trans-ferulic acid accounts for the vascular protective effect. Normotensive rats fed a high-salt diet showed significantly increased systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP), which decreased significantly in the SE-treated groups. In SHRs, high edible salt intake significantly increased SBP, DBP, and MAP, but SE intake was associated with a significantly lower MAP. Thus, SE did not induce vascular dysfunction, and trans-ferulic acid might be at least partly responsible for the vasoprotective effect of SE. Taken together, SE could be used as an alternative to purified salt to prevent and ameliorate hypertension.
authors.affiliation: College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Muan-gun, Jeonnam 58554, Korea. panth.nisha1@gmail.com.
authors.forename: Nisha
authors.initials: N
authors.lastname: Panth
authors.affiliation: College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Muan-gun, Jeonnam 58554, Korea. sin-hee.park@unistra.fr.|UMR CNRS 7213, Laboratoire de Biophotonique et Pharmacologie, Facult&#233; de Pharmacie, Universit&#233; de Strasbourg, Illkirch 67401, France. sin-hee.park@unistra.fr.
authors.forename: Sin-Hee
authors.initials: SH
authors.lastname: Park
authors.affiliation: College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Muan-gun, Jeonnam 58554, Korea. hyunkim@mokpo.ac.kr.
authors.forename: Hyun Jung
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Research Center, Phyto Corporation, Seoul 08826, Korea. dhkim@phytoco.com.
authors.forename: Deuk-Hoi
authors.initials: DH
authors.lastname: Kim
authors.affiliation: College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Muan-gun, Jeonnam 58554, Korea. mhoak@mokpo.ac.kr.
authors.forename: Min-Ho
authors.initials: MH
authors.lastname: Oak
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001835:Body Weight; D002318:Cardiovascular Diseases / Q000139:chemically induced / Q000188:drug therapy*; D019663:Chenopodiaceae / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D006973:Hypertension / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D017207:Rats, Sprague-Dawley; D017673:Sodium Chloride, Dietary / Q000633:toxicity*; D013552:Swine
chemical_list: D010936:Plant Extracts; D017673:Sodium Chloride, Dietary
keywords: Salicornia europaea; blood pressure; hypertension; vascular dysfunction