title: MtDNA T4216C variation in multiple sclerosis: a systematic review and meta-analysis.
abstract: MtDNA T4216C variation has frequently been investigated in Multiple Sclerosis (MS) patients; nonetheless, controversy has existed about the evidence of association of this variation with susceptibility to MS. The present systematic review and meta-analysis converge the results of the preceding publications, pertaining to association of mtDNA T4216C variation with susceptibility to MS, into a common conclusion. A computerized literature search in English was carried out to retrieve relevant publications from which required data were extracted. Using a fixed effect model, pooled odds ratio (OR), 95 % confidence interval (95 % CI), and P value were calculated for association of mtDNA T4216C variation with susceptibility to MS. The pooled results showed that there was a significant association between mtDNA T4216C variation and MS (OR = 1.38, 95 % CI = 1.13-1.67, P = 0.001). The present systematic review and meta-analysis suggest that mtDNA T4216C variation is a contributory factor in susceptibility to MS.
authors.affiliation: Department of Neurosurgery, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: Sasan
authors.initials: S
authors.lastname: Andalib
authors.affiliation: Department of Neurosurgery, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. neurosurgery96@yahoo.com.
authors.forename: Mohammadreza
authors.initials: M
authors.lastname: Emamhadi
authors.affiliation: Department of Neurosurgery, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: Shahrokh
authors.initials: S
authors.lastname: Yousefzadeh-Chabok
authors.affiliation: Department of Cardiology and Cardiology Research Center, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: Arsalan
authors.initials: A
authors.lastname: Salari
authors.affiliation: Department of Health and Social Determinants of Health Research Center, School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: Abdolhosein Emami
authors.initials: AE
authors.lastname: Sigaroudi
authors.affiliation: Department of Psychiatry, University of Southern Denmark & Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark.
authors.forename: Manouchehr Seyedi
authors.initials: MS
authors.lastname: Vafaee
mesh_terms: D004272:DNA, Mitochondrial / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D009103:Multiple Sclerosis / Q000235:genetics*; D009245:NADH Dehydrogenase / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D004272:DNA, Mitochondrial; D009245:NADH Dehydrogenase; C515075:NADH dehydrogenase subunit 1, human
keywords: MS; Meta-analysis; Mitochondrial DNA; Multiple Sclerosis; Systematic review; T4216C; Variation; mtDNA