title: Aspergivones A and B, two new flavones isolated from a gorgonian-derived Aspergillus candidus fungus.
abstract: Two new flavones, aspergivones A (1) and B (2), were isolated from the fungus Aspergillus candidus cultured from the gorgonian coral Anthogorgia ochracea collected from the South China Sea. The structures of 1 and 2 were elucidated by NMR and MS methods and comparison with relatively known compounds. Only 2 showed slight inhibitory activity against alpha-glucosidase with an IC50value of 244 μg/mL. Compounds 1 and 2 were also evaluated for their cytotoxic and antibacterial activities.
authors.affiliation: a Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy , Ocean University of China , Qingdao , P.R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Ma
authors.affiliation: a Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy , Ocean University of China , Qingdao , P.R. China.
authors.forename: Xiu-Li
authors.initials: XL
authors.lastname: Zhang
authors.affiliation: a Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy , Ocean University of China , Qingdao , P.R. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: b State Key Laboratory for Marine Corrosion and Protection , Luoyang Ship Material Research Institute (LSMRI) , Qingdao , P.R. China.
authors.forename: Ji-Yong
authors.initials: JY
authors.lastname: Zheng
authors.affiliation: a Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy , Ocean University of China , Qingdao , P.R. China.|c Laboratory for Marine Drugs and Bioproducts , Qingdao National Laboratory for Marine Science and Technology , Qingdao , P.R. China.
authors.forename: Chang-Yun
authors.initials: CY
authors.lastname: Wang
authors.affiliation: a Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy , Ocean University of China , Qingdao , P.R. China.|c Laboratory for Marine Drugs and Bioproducts , Qingdao National Laboratory for Marine Science and Technology , Qingdao , P.R. China.
authors.forename: Chang-Lun
authors.initials: CL
authors.lastname: Shao
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000382:microbiology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D001230:Aspergillus / Q000737:chemistry*; D001419:Bacteria / Q000187:drug effects; D002681:China; D004791:Enzyme Inhibitors / Q000494:pharmacology; D047309:Flavones / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D000520:alpha-Glucosidases / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D047309:Flavones; C000618173:aspergivone A; C000618174:aspergivone B; D000520:alpha-Glucosidases
keywords: Aspergillus candidus; alpha-glucosidase; flavone; gorgonian coral