title: Immunophenotypes and Gene Rearrangements of the T-Cell Receptor in Two Patients with a Large Granular Lymphocyte Disorder.
abstract: Large granular lymphocyte disorder (LGLD) is a lymphoproliferative disease, characterized by moderate lymphocytosis with an excess of large granular lymphocytes, neutropenia, anemia, and a variable, but mostly chronic clinical course. We describe two patients with LGLD. One patient presented with symptomatic corticoster-oid-responsive hemolytic anemia, while the other had a chronic course not requiring therapy. The majority of lymphocytes from both patients were CD8 + T lymphocytes. However, the cells from the two patients differed in the molecular pattern of the T cell receptor (TCR), and this may explain the difference in their clinical course.
authors.affiliation: a Department of Hematology, Assaf Harofeh Medical Center, Zerifin, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Peller
authors.affiliation: a Department of Hematology, Assaf Harofeh Medical Center, Zerifin, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Kaufman
authors.affiliation: b Department of Cell Biology, The Weizman Institute of Science, Rehovot, Israel.
authors.forename: V
authors.initials: V
authors.lastname: Rotter
keywords: T-cell receptor; large granular lymphocyte disorder