title: A novel approach for multi-SNP GWAS and its application in Alzheimer's disease.
abstract: BACKGROUND
  Genome-wide association studies (GWAS) have effectively identified genetic factors for many diseases. Many diseases, including Alzheimer's disease (AD), have epistatic causes, requiring more sophisticated analyses to identify groups of variants which together affect phenotype.
  
  
  RESULTS
  Based on the GWAS statistical model, we developed a multi-SNP GWAS analysis to identify pairs of variants whose common occurrence signaled the Alzheimer's disease phenotype.
  
  
  CONCLUSIONS
  Despite not having sufficient data to demonstrate significance, our preliminary experimentation identified a high correlation between GRIA3 and HLA-DRB5 (an AD gene). GRIA3 has not been previously reported in association with AD, but is known to play a role in learning and memory.
authors.affiliation: Computer Science Department, Brigham Young University, Provo, 84602-6576, UT, USA. paulmbodily@gmail.com.
authors.forename: Paul M
authors.initials: PM
authors.lastname: Bodily
authors.affiliation: Computer Science Department, Brigham Young University, Provo, 84602-6576, UT, USA.
authors.forename: M Stanley
authors.initials: MS
authors.lastname: Fujimoto
authors.affiliation: Department of Biology, Brigham Young University, Provo, 84602-6576, UT, USA.
authors.forename: Justin T
authors.initials: JT
authors.lastname: Page
authors.affiliation: Computer Science Department, Brigham Young University, Provo, 84602-6576, UT, USA.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Clement
authors.affiliation: Department of Biology, Brigham Young University, Provo, 84602-6576, UT, USA.
authors.forename: Mark T W
authors.initials: MT
authors.lastname: Ebbert
authors.affiliation: Department of Biology, Brigham Young University, Provo, 84602-6576, UT, USA.
authors.forename: Perry G
authors.initials: PG
authors.lastname: Ridge
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics* / Q000378:metabolism; D019295:Computational Biology / Q000379:methods*; D004843:Epistasis, Genetic; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study / Q000379:methods*; D059847:HLA-DRB5 Chains / Q000235:genetics; D006801:Humans; D008297:Male; D015233:Models, Statistical; D020641:Polymorphism, Single Nucleotide; D018091:Receptors, AMPA / Q000235:genetics
chemical_list: D059847:HLA-DRB5 Chains; D018091:Receptors, AMPA; C104723:glutamate receptor ionotropic, AMPA 3
keywords: Alzheimer’s disease; Epistasis; GWAS; Multi-SNP GWAS