title: Voltage-Gated P/Q-Type Calcium Channel Antibodies Associated With Cerebellar Degeneration.
abstract: Paraneoplastic cerebellar degeneration is a rare neurological condition characterized by diffuse cerebellar dysfunction and magnetic resonance imaging evidence of progressive cerebellar atrophy. It has been associated with several autoantibodies and malignancies in adults. To date, only six cases have been described in male children.
  
  
  
  We describe an eight-year-old girl with a prodrome of abdominal pain and vomiting followed by acute onset diplopia, dysarthria, dysmetria, and ataxia. She was found to have cerebellar degeneration in association with P/Q-type calcium channel antibodies.
  
  
  
  This is the first child with documented paraneoplastic cerebellar degeneration in association with P/Q-type calcium channel antibodies.
authors.affiliation: Saul R. Korey Department of Neurology, Montefiore Medical Center, Bronx, New York. Electronic address: mspiciar@montefiore.org.
authors.forename: Mary C
authors.initials: MC
authors.lastname: Spiciarich
authors.affiliation: Saul R. Korey Department of Neurology, Montefiore Medical Center, Bronx, New York; Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York; Department of Pediatrics, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York.
authors.forename: Solomon L
authors.initials: SL
authors.lastname: Moshé
mesh_terms: D001323:Autoantibodies / Q000276:immunology*; D001921:Brain / Q000000981:diagnostic imaging; D020865:Calcium Channels, P-Type / Q000276:immunology*; D020907:Calcium Channels, Q-Type / Q000276:immunology*; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D020362:Paraneoplastic Cerebellar Degeneration / Q000175:diagnosis* / Q000276:immunology* / Q000628:therapy
chemical_list: D001323:Autoantibodies; D020865:Calcium Channels, P-Type; D020907:Calcium Channels, Q-Type
keywords: cerebellar degeneration; child; female; paraneoplastic; voltage-gated calcium channel antibodies