title: Evaluation of globins expression in brain, heart, and lung in rats exposed to side stream cigarette smoke.
abstract: The side stream cigarette smoke (SSCS) is a contributing factor in the pathogenesis of cigarette smoking-induced toxicity. Hemoglobin (Hb), myoglobin (Mb), neuroglobin (Ngb), and cytoglobin (Cygb) are globins with different distributions and functions in the tissues and have similar actions by providing O2(oxygen) for respiratory chain, detoxification of ROS and nitric oxide (NO), and protect tissues against irreversible lesions. We aimed to investigate the effects of SSCS exposure on gene and protein expression of Ngb, Cygb, and Mb in different tissue. The Ngb and Cygb gene and protein expression in the cerebral cortex increased after 1 week of rat exposure to SSCS. In hippocampus, the Ngb gene and protein expression increased after 1 week or more of exposure and no change was observed in Cygb gene and protein expression. In myocardium, Mb and Cygb gene expression increased at 1 and 4 weeks of exposure, while protein expression of both increased at 1, 2, 3, and 4 weeks. In lung, observed an increase in Cygb gene and protein expression after 2, 3, and 4 weeks of exposure. The findings suggest that SSCS modulates Ngb, Cygb, and Mb in central and peripheral tissue © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1252-1261, 2017.
authors.affiliation: Departament of Morphology and Physiology, Faculdade de Medicina do ABC, Santo André, SP, Brazil.
authors.forename: Barbara
authors.initials: B
authors.lastname: Tae
authors.affiliation: Departament of Morphology and Physiology, Faculdade de Medicina do ABC, Santo André, SP, Brazil.|Departament of Medicine, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors.forename: Kelen Carneiro
authors.initials: KC
authors.lastname: Oliveira
authors.affiliation: Departament of Medicine, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors.forename: Rodrigo Rodrigues da
authors.initials: RR
authors.lastname: Conceição
authors.affiliation: Faculdade de Ciências e Tecnologia, Universidade Estadual Paulista, Marília, SP, Brazil.
authors.forename: Vitor Engrácia
authors.initials: VE
authors.lastname: Valenti
authors.affiliation: Departament of Medicine, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors.forename: Janaina Sena
authors.initials: JS
authors.lastname: de Souza
authors.affiliation: Departament of Medicine, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors.forename: Roberto
authors.initials: R
authors.lastname: Laureano-Melo
authors.affiliation: Departament of Morphology and Physiology, Faculdade de Medicina do ABC, Santo André, SP, Brazil.
authors.forename: Monica Akemi
authors.initials: MA
authors.lastname: Sato
authors.affiliation: Departament of Medicine, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors.forename: Rui Monteiro de Barros
authors.initials: RM
authors.lastname: Maciel
authors.affiliation: Departament of Morphology and Physiology, Faculdade de Medicina do ABC, Santo André, SP, Brazil.|Departament of Medicine, Universidade Federal de São Paulo, São Paulo, SP, Brazil.|Department of Biological Sciences, Universidade Federal de São Paulo, Diadema, SP, Brazil.
authors.forename: Gisele
authors.initials: G
authors.lastname: Giannocco
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D000078842:Cytoglobin; D005914:Globins / Q000235:genetics / Q000378:metabolism*; D006454:Hemoglobins / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism*; D008168:Lung / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D000078787:Neuroglobin; D051381:Rats; D017208:Rats, Wistar; D012907:Smoking
chemical_list: C000627268:Cygb protein, rat; D000078842:Cytoglobin; D006454:Hemoglobins; D009419:Nerve Tissue Proteins; D000078787:Neuroglobin; D005914:Globins
keywords: cigarette smoke; cytoglobin; myoglobin; neuroglobin