title: Alleviation of 4-nitroquinoline 1-oxide induced oxidative stress by Oroxylum indicum (L.) leaf extract in albino Wistar rats.
abstract: BACKGROUND
  4-nitroquinoline 1-oxide (4-NQO) is a mutagen known to be responsible for causing cancer by generating oxidative stress in humans. Oroxylum indicum (L.) possesses various bioactive compounds with antioxidant properties. In this connection, the present study aims to analyze the alleviation of 4-NQO induced oxidative stress in albino Wistar rats using O. indicum (L.) leaf extract.
  
  
  METHODS
  O. indicum (L.) belonging to the family Bignoniaceae, has anticancer and anti-inflammatory properties. In this study, we observed severe oxidative stress in 4-NQO induced albino Wistar rats when compared to untreated control. Alleviation of this condition was seen after the oral administration of O. indicum (L.) leaf extract at 50, 100, and 200 mg/kg body weight.
  
  
  RESULTS
  4-NQO (50 ppm) administration in drinking water resulted in the generation of reactive oxygen species (ROS) leading to cellular damage, lipid peroxidation and imbalance in antioxidant status. Administration of O. indicum (L.) leaf extract has alleviated the level of 4-NQO induced oxidative stress by increasing the antioxidant status and decreasing the elevation of liver markers in serum.
  
  
  CONCLUSIONS
  Results clearly suggest that O. indicum (L.) leaf extract when administered orally in a dose dependent manner has the ability to overcome the oxidative stress induced by 4-NQO with hepatoprotective and lipid protective properties.
authors.affiliation: Department of Plant Biotechnology, School of Bio Sciences and Technology, VIT University, Vellore, 632014, Tamil Nadu, India.
authors.forename: Shalini
authors.initials: S
authors.lastname: Mohan
authors.affiliation: Department of Plant Biotechnology, School of Bio Sciences and Technology, VIT University, Vellore, 632014, Tamil Nadu, India.
authors.forename: Kalaivani
authors.initials: K
authors.lastname: Thiagarajan
authors.affiliation: Department of Plant Biotechnology, School of Bio Sciences and Technology, VIT University, Vellore, 632014, Tamil Nadu, India.
authors.forename: Balaji
authors.initials: B
authors.lastname: Sundaramoorthy
authors.affiliation: Department of Plant Biotechnology, School of Bio Sciences and Technology, VIT University, Vellore, 632014, Tamil Nadu, India.
authors.forename: Vivek
authors.initials: V
authors.lastname: Gurung
authors.affiliation: Department of Plant Biotechnology, School of Bio Sciences and Technology, VIT University, Vellore, 632014, Tamil Nadu, India.
authors.forename: Manas
authors.initials: M
authors.lastname: Barpande
authors.affiliation: Department of Plant Biotechnology, School of Bio Sciences and Technology, VIT University, Vellore, 632014, Tamil Nadu, India.
authors.forename: Shilpi
authors.initials: S
authors.lastname: Agarwal
authors.affiliation: Department of Plant Biotechnology, School of Bio Sciences and Technology, VIT University, Vellore, 632014, Tamil Nadu, India. drcrs70@gmail.com.
authors.forename: Rajasekaran
authors.identifier: http://orcid.org/0000-0002-1553-0907
authors.initials: R
authors.lastname: Chandrasekaran
mesh_terms: D015112:4-Nitroquinoline-1-oxide / Q000737:chemistry / Q000633:toxicity*; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D029402:Bignoniaceae / Q000737:chemistry*; D001786:Blood Glucose / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D008055:Lipids; D010936:Plant Extracts; D015112:4-Nitroquinoline-1-oxide
keywords: 4-nitroquinoline 1-oxide; Anticancer; Antioxidant; Oroxylum indicum (L.); Oxidative stress