title: Psoriasis and risk of incident atrial fibrillation: A systematic review and meta-analysis.
abstract: OBJECTIVE
  Patients with psoriasis might have a higher risk of developing atrial fibrillation as a result of chronic inflammation. This study aimed to investigate this association by comprehensively reviewing all available evidence.
  
  
  METHODS
  We conducted a systematic review and meta-analysis of cohort studies that reported relative risk, hazard ratio, incidence ratio or standardized incidence ratio with 95% confidence intervals comparing the risk of incident atrial fibrillation in patients with psoriasis versus participants without psoriasis. Both retrospective and prospective cohort studies were eligible. Pooled risk ratio and 95% confidence intervals were calculated using random-effect, generic inverse variance methods of DerSimonian and Laird.
  
  
  RESULTS
  Three retrospective studies with 110,568 cases of psoriasis and 5,352,817 participants without psoriasis were included in this meta-analysis. The pooled risk ratio of subsequent development of atrial fibrillation in patients with psoriasis versus participants without psoriasis was 1.21 (95% confidence interval, 1.14-1.29). The statistical heterogeneity was low with an I2 of 29%.
  
  
  CONCLUSIONS
  Coding-based design of the primary studies that had limited accuracy.
  
  
  CONCLUSIONS
  Our meta-analysis demonstrated a statistically significant increase in the risk of incident atrial fibrillation among patients with psoriasis.
authors.affiliation: Department of Internal Medicine, Division of Rheumatology, Mayo Clinic, Rochester, MN, USA; Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, .
authors.forename: Patompong
authors.initials: P
authors.lastname: Ungprasert
authors.affiliation: Department of Internal Medicine, Division of Pulmonology and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA.
authors.forename: Narat
authors.initials: N
authors.lastname: Srivali
authors.affiliation: Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
authors.forename: Wonngarm
authors.initials: W
authors.lastname: Kittanamongkolchai
mesh_terms: D001281:Atrial Fibrillation / Q000175:diagnosis* / Q000453:epidemiology* / Q000209:etiology; D015331:Cohort Studies; D006801:Humans; D015994:Incidence; D011446:Prospective Studies; D011565:Psoriasis / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology*; D012189:Retrospective Studies; D012307:Risk Factors