title: Three New Ergot Alkaloids from the Fruiting Bodies of Xylaria nigripes (Kl.) Sacc.
abstract: Three new ergot alkaloids, xylanigripones A - C (1 - 3) together with three known compounds, agroclavine (4), 8,9-didehydro-10-hydroxy-6,8-dimethylergolin (5), and (6S)-agroclavine N-oxide (6) were isolated from the fungus Xylaria nigripes (Kl.) Sacc. Their structures were elucidated by comprehensive spectroscopic analyses and high-resolution mass spectrometry as well as by comparison with the literature. The absolute configuration was determined by Density Functional Theory (DFT) calculation methods. In addition, all of the compounds were evaluated for bioactivity via a cytotoxicity assay, an acetylcholinesterase inhibition assay and a cholesterol ester transfer protein inhibition assay.
authors.affiliation: College of Resource and Environment, Yuxi Normal University, Yuxi, 653100, P. R. China.|State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Lanhei Road 132, Kunming, 650201, P. R. China.
authors.forename: Dongbao
authors.initials: D
authors.lastname: Hu
authors.affiliation: College of Resource and Environment, Yuxi Normal University, Yuxi, 653100, P. R. China.
authors.forename: Ming
authors.initials: M
authors.lastname: Li
mesh_terms: D004876:Ergot Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology / Q000633:toxicity; D004881:Ergotism; D048690:Fruiting Bodies, Fungal / Q000737:chemistry*; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013098:Xylariales / Q000737:chemistry*
chemical_list: D004876:Ergot Alkaloids
keywords: 
  Xylaria nigripes
  ; CETP Inhibitory activity; DFT; Ergot alkaloids