title: Repurposing Metformin as Therapy for Prostate Cancer within the STAMPEDE Trial Platform.
abstract: Metformin is a safe, well-tolerated, inexpensive treatment that can be given in addition to current standard-of-care therapies for prostate cancer. Its use might mitigate the deleterious side effects of castration and exert an additional anticancer effect. It will be incorporated in the STAMPEDE trial platform in summer 2016. This will test its true utility as a repurposed treatment for men with high-risk locally advanced or metastatic prostate cancer at first presentation.
authors.affiliation: Department of Oncology/Haematology, Kantonsspital, St. Gallen, Switzerland.
authors.forename: Silke
authors.initials: S
authors.lastname: Gillessen
authors.affiliation: MRC Clinical Trials Unit, University College London, London, UK.
authors.forename: Clare
authors.initials: C
authors.lastname: Gilson
authors.affiliation: Warwick Medical School, University of Warwick, Coventry, UK; University Hospitals Birmingham NHS Foundation Trust, The Medical School, University of Birmingham, Birmingham, UK.
authors.forename: Nick
authors.initials: N
authors.lastname: James
authors.affiliation: Diabetes Service, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: Amanda
authors.initials: A
authors.lastname: Adler
authors.affiliation: MRC Clinical Trials Unit, University College London, London, UK.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Sydes
authors.affiliation: Department of Urology, The Christie and Salford Royal NHS Foundation Trusts, Manchester, UK. Electronic address: noel.clarke@christie.nhs.uk.
authors.forename: Noel
authors.initials: N
authors.lastname: Clarke
mesh_terms: D000726:Androgen Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D058492:Drug Repositioning; D004359:Drug Therapy, Combination; D006801:Humans; D006943:Hyperglycemia / Q000139:chemically induced / Q000517:prevention & control*; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008297:Male; D008687:Metformin / Q000627:therapeutic use*; D009362:Neoplasm Metastasis; D009919:Orchiectomy / Q000009:adverse effects / Q000379:methods*; D011471:Prostatic Neoplasms / Q000473:pathology / Q000628:therapy*
chemical_list: D000726:Androgen Antagonists; D007004:Hypoglycemic Agents; D008687:Metformin