title: DisSim: an online system for exploring significant similar diseases and exhibiting potential therapeutic drugs.
abstract: The similarity of pair-wise diseases reveals the molecular relationships between them. For example, similar diseases have the potential to be treated by common therapeutic chemicals (TCs). In this paper, we introduced DisSim, an online system for exploring similar diseases, and comparing corresponding TCs. Currently, DisSim implemented five state-of-the-art methods to measure the similarity between Disease Ontology (DO) terms and provide the significance of the similarity score. Furthermore, DisSim integrated TCs of diseases from the Comparative Toxicogenomics Database (CTD), which can help to identify potential relationships between TCs and similar diseases. The system can be accessed from http://123.59.132.21:8080/DisSim.
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, PR China.
authors.forename: Liang
authors.initials: L
authors.lastname: Cheng
authors.affiliation: Hospital for Sick Children, Toronto, Canada.
authors.forename: Yue
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, PR China.
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Wang
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, PR China.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Shi
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, PR China.
authors.forename: Jie
authors.initials: J
authors.lastname: Sun
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, PR China.
authors.forename: Haixiu
authors.initials: H
authors.lastname: Yang
authors.affiliation: School of Management, Harbin University of Commerce, Harbin 150081, PR China.
authors.forename: Shuo
authors.initials: S
authors.lastname: Zhang
authors.affiliation: School of Life Science and Technology, Harbin Institute of Technology, Harbin 150081, PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Hu
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, PR China.
authors.forename: Meng
authors.initials: M
authors.lastname: Zhou
mesh_terms: D016208:Databases, Factual; D004194:Disease; D004358:Drug Therapy; D006801:Humans; D009862:Online Systems; D002620:Pharmacological and Toxicological Phenomena; D043922:Toxicogenetics