title: Modulating protein quality control.
abstract: Small molecules that modulate the unfolded protein response have the potential to treat a variety of human protein misfolding diseases.
authors.affiliation: Department of Chemistry, The Scripps Research Institute, La Jolla, United States.|Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, United States.
authors.forename: Lars
authors.identifier: 0000-0003-4363-6116
authors.initials: L
authors.lastname: Plate
authors.affiliation: Department of Chemistry, The Scripps Research Institute, La Jolla, United States.
authors.forename: Ryan J
authors.identifier: 0000-0001-6421-1892
authors.initials: RJ
authors.lastname: Paxman
authors.affiliation: Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, United States.|Department of Chemical Physiology, The Scripps Research Institute, La Jolla, United States.
authors.forename: R Luke
authors.identifier: 0000-0001-9287-6840
authors.initials: RL
authors.lastname: Wiseman
authors.affiliation: Department of Chemistry, The Scripps Research Institute, La Jolla, United States.|Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, United States.
authors.forename: Jeffery W
authors.initials: JW
authors.lastname: Kelly
mesh_terms: D051702:Activating Transcription Factor 6 / Q000235:genetics*; D006801:Humans; D057165:Proteostasis Deficiencies; D056811:Unfolded Protein Response; D019892:eIF-2 Kinase / Q000235:genetics
chemical_list: D051702:Activating Transcription Factor 6; D019892:eIF-2 Kinase
keywords: ATF6-alpha; ER stress; cell biology; endoplasmic reticulum; human; site-1-protease; small molecule screening; unfolded protein response