title: Association of elevated triglycerides and acute myocardial infarction in young Hispanics.
abstract: BACKGROUND
  Previous studies have demonstrated that acute myocardial infarction (AMI) in young patients (age <45years) is associated with a high prevalence of smoking, obesity, hyperlipidemia and single vessel coronary artery disease (CAD). Hispanics represent the largest growing ethnic minority in the United States, yet features of AMI in young Hispanics have not been described.
  
  
  METHODS
  Patients undergoing percutaneous coronary intervention for AMI at Los Angeles County + University of Southern California Medical Center and Keck Medical Center were studied. We compared young Hispanics (age<45, n=47) with older patients (Hispanics and non-Hispanics age ≥45, n=888) to identify unique features of AMI in young Hispanics. We also compared young Hispanics with young non-Hispanics (n=33) and older Hispanics (n=447) in regards to traditional CAD risk factors, laboratory values and in-hospital outcomes. Multivariable logistic regression was performed to identify variables independently associated with in-hospital mortality.
  
  
  RESULTS
  Young Hispanics had higher triglyceride levels than young non-Hispanics and older patients (234.5±221.0mg/dL vs. 145.3±67.4mg/dL vs. 156±118.2mg/dL, p<0.0004); and higher triglyceride than older Hispanics (234.5±221.0 vs. 147.0±98.9mg/dL, p<0.02). Body mass index was independently associated with the logarithm (base10) of triglyceride levels (p<0.0001). Hispanic ethnicity and age<45years, however, were not independently associated with in-hospital mortality.
  
  
  CONCLUSIONS
  Young Hispanics with AMI have higher triglyceride levels than young non-Hispanics and older Hispanics. The elevated triglyceride levels may be related to lifestyle changes experienced by a young immigrant population transitioning to life in the United States.
authors.affiliation: Division of Cardiovascular Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA, 90033. Electronic address: gessilfie@gmail.com.
authors.forename: Gilbert
authors.initials: G
authors.lastname: Essilfie
authors.affiliation: Division of Cardiovascular Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA, 90033.
authors.forename: David M
authors.initials: DM
authors.lastname: Shavelle
authors.affiliation: Division of Cardiovascular Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA, 90033.
authors.forename: Han
authors.initials: H
authors.lastname: Tun
authors.affiliation: Division of Cardiovascular Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA, 90033.
authors.forename: Kevin
authors.initials: K
authors.lastname: Platt
authors.affiliation: Division of Cardiovascular Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA, 90033.
authors.forename: Ryan
authors.initials: R
authors.lastname: Kobayashi
authors.affiliation: Division of Cardiovascular Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA, 90033.
authors.forename: Anilkumar
authors.initials: A
authors.lastname: Mehra
authors.affiliation: Division of Cardiovascular Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA, 90033.
authors.forename: Ray V
authors.initials: RV
authors.lastname: Matthews
authors.affiliation: Division of Cardiovascular Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA, 90033.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Clavijo
authors.affiliation: Division of Cardiovascular Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA, 90033.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Gaglia
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D017023:Coronary Angiography; D005260:Female; D006630:Hispanic or Latino; D017052:Hospital Mortality / Q000208:ethnology; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood / Q000175:diagnosis / Q000208:ethnology* / Q000401:mortality; D016014:Linear Models; D016015:Logistic Models; D015141:Los Angeles / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D000072658:Non-ST Elevated Myocardial Infarction / Q000175:diagnosis / Q000208:ethnology* / Q000401:mortality / Q000628:therapy; D062645:Percutaneous Coronary Intervention; D018570:Risk Assessment; D012307:Risk Factors; D000072657:ST Elevation Myocardial Infarction / Q000175:diagnosis / Q000208:ethnology* / Q000401:mortality / Q000628:therapy; D013997:Time Factors; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood*; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D014280:Triglycerides
keywords: Acute myocardial infarction; Coronary artery disease; Hispanic; Metabolic syndrome; Percutaneous coronary; Triglyceride