title: Expression and clinical significance of Apollon in esophageal squamous cell carcinoma.
abstract: Apollon, an unusually large member of the inhibitors of apoptosis protein family, may be important for oncogenesis development. The aim of the present study was to assess the association between esophageal squamous cell carcinoma (ESCC) and Apollon expression levels, and to highlight the association between Apollon and the occurrence, development and prognosis of ESCC. Apollon expression was detected by immunohistochemical staining and reverse transcription-quantitative polymerase chain reaction in ESCC tissues, adjacent non‑cancerous tissues and paired normal tissues respectively, in order to analyze the association between Apollon expression and the clinicopathological features of ESCC. Survival analysis was used to assess the prognostic significance of Apollon expression. It was determined that the mRNA and protein expression levels of Apollon were significantly higher in the carcinoma tissues compared with the adjacent non‑cancerous tissues and normal control tissues (P<0.001). There was a significant difference in lymph node involvement and the tumor, nodes, and metastases stage in patients categorized according to different Apollon expression levels. The prognostic significance of Apollon was also determined using the log‑rank method. The overexpression of Apollon was associated with shorter overall survival and disease-free survival rates. The present study indicates that Apollon expression is associated with the biological characteristics of ESCC, and may be a valuable prognostic factor and a novel chemotherapeutic target for ESCC treatment.
authors.affiliation: Department of Gastroenterology, Xiangya Hospital, Changsha, Hunan 410008, P.R. China.
authors.forename: Rong
authors.initials: R
authors.lastname: Li
authors.affiliation: Thoracic Medicine Department II, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South Univerisity, Changsha, Hunan 410013, P.R. China.
authors.forename: Bo-Lin
authors.initials: BL
authors.lastname: Chen
authors.affiliation: Department of Thoracic Surgery, Xiangya Hospital, Central South Univerisity, Changsha, Hunan 410008, P.R. China.
authors.forename: Yan-Wu
authors.initials: YW
authors.lastname: Zhou
authors.affiliation: Department of Gastroenterology, Xiangya Hospital, Changsha, Hunan 410008, P.R. China.
authors.forename: Ren-Wei
authors.initials: RW
authors.lastname: Guo
authors.affiliation: Department of Gastroenterology, Xiangya Hospital, Changsha, Hunan 410008, P.R. China.
authors.forename: Meng-Ting
authors.initials: MT
authors.lastname: Shuai
authors.affiliation: Department of Clinical Medicine, Hunan Xiangnan College, Chenzhou, Hunan 423043, P.R. China.
authors.forename: Jun-Xian
authors.initials: JX
authors.lastname: Zeng
authors.affiliation: Department of Gastroenterology, Xiangya Hospital, Changsha, Hunan 410008, P.R. China.
authors.forename: Ai-Min
authors.initials: AM
authors.lastname: Leng
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D004938:Esophageal Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D000077277:Esophageal Squamous Cell Carcinoma; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016019:Survival Analysis
chemical_list: C401541:BIRC6 protein, human; D051034:Inhibitor of Apoptosis Proteins