title: Periodontal infectogenomics: systematic review of associations between host genetic variants and subgingival microbial detection.
abstract: Recent research is increasingly showing that host genetic variants can affect the colonization by specific microbes. The aim of this study was to systematically investigate the associations between host genetic variants and subgingival microbial detection and counts.
  
  
  
  A systematic search of the literature was conducted in Ovid Medline, Embase, LILACS and Cochrane Library for studies reporting data on host genetic variants and detection of microbes subgingivally.
  
  
  
  A total of 43 studies were included in the review, from an initial search of 3887 titles. Studies consisted mainly of candidate gene studies and of one genome-wide analysis. Some promising associations were detected between single nucleotide polymorphisms and microbial detection. The only feasible meta-analysis failed to show any association between Interleukin 1 (IL1) genetic variants and detection of periodontopathogenic bacteria subgingivally.
  
  
  
  There is no evidence yet that neither IL1 genetic polymorphisms nor other investigated genetic polymorphisms are associated with presence and counts of subgingival bacteria. Further studies on large populations with replication samples should clarify the possible effects of other genetic variants on the subgingival microbiota.
authors.affiliation: Clinical Oral Research Centre, Institute of Dentistry, Queen Mary University London (QMUL), London, UK. l.nibali@qmul.ac.uk.
authors.forename: Luigi
authors.initials: L
authors.lastname: Nibali
authors.affiliation: Library Services, UCL Eastman Dental Institute, London, UK.
authors.forename: Anna
authors.initials: A
authors.lastname: Di Iorio
authors.affiliation: Private Practice, London, UK.
authors.forename: Olanrewaju
authors.initials: O
authors.lastname: Onabolu
authors.affiliation: Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
authors.forename: Guo-Hao
authors.initials: GH
authors.lastname: Lin
mesh_terms: D001419:Bacteria; D023281:Genomics; D006801:Humans; D007239:Infections; D010518:Periodontitis; D020641:Polymorphism, Single Nucleotide
keywords: bacteria; genetic; infectogenomics; periodontitis