title: Association between the HTR2C rs1414334 C/G gene polymorphism and the development of the metabolic syndrome in patients treated with atypical antipsychotics.
abstract: Few studies have assessed the association between the rs1414334 C/G polymorphism in the HTR2C gene and the development of the metabolic syndrome in patients treated with atypical antipsychotics. To provide further evidence, a cross-sectional study was conducted in Spain between 2012 and 2013 in 166 patients with these characteristics. In these patients, the association between the polymorphism and the presence of the metabolic syndrome was determined by implementing binary logistic regression models adjusted for variables associated with the metabolic syndrome. We did not confirm previous claims that the C allele of the polymorphism was linked to the metabolic syndrome: the association was in the opposite direction and non-significant. This conclusion held after taking gender and lifestyle variables into account.
authors.affiliation: Department of Clinical Medicine, Miguel Hernández University, San Juan de Alicante, Alicante, Spain; Department of Psychiatry, General University Hospital of Elche, Elche, Alicante, Spain.
authors.forename: José María
authors.initials: JM
authors.lastname: Rico-Gomis
authors.affiliation: Department of Clinical Medicine, Miguel Hernández University, San Juan de Alicante, Alicante, Spain; Research Unit, General University Hospital of Elda, Elda, Alicante, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Palazón-Bru
authors.affiliation: Pharmacy Service, General University Hospital of Elche , Elche , Alicante , Spain.
authors.forename: Irene
authors.initials: I
authors.lastname: Triano-García
authors.affiliation: Department of Psychiatry, General University Hospital of Elche , Elche , Alicante , Spain.
authors.forename: Luis Fabián
authors.initials: LF
authors.lastname: Mahecha-García
authors.affiliation: Pharmacy Service, General University Hospital of Elche , Elche , Alicante , Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: García-Monsalve
authors.affiliation: Pharmacy Service, General University Hospital of Elche , Elche , Alicante , Spain.
authors.forename: Andrés
authors.initials: A
authors.lastname: Navarro-Ruiz
authors.affiliation: Department of Psychiatry, General University Hospital of Elche , Elche , Alicante , Spain.
authors.forename: Berta
authors.initials: B
authors.lastname: Villagordo-Peñalver
authors.affiliation: Department of Psychiatry, General University Hospital of Elche , Elche , Alicante , Spain.
authors.forename: Jessica
authors.initials: J
authors.lastname: Jiménez-Abril
authors.affiliation: Department of Psychiatry, General University Hospital of Elche , Elche , Alicante , Spain.
authors.forename: Alicia
authors.initials: A
authors.lastname: Martínez-Hortelano
authors.affiliation: Department of Clinical Medicine, Miguel Hernández University, San Juan de Alicante, Alicante, Spain; Research Unit, General University Hospital of Elda, Elda, Alicante, Spain.
authors.forename: Vicente Francisco
authors.initials: VF
authors.lastname: Gil-Guillén
keywords: Antipsychotic agents; HTR2C; Metabolic syndrome X; Pharmacogenetics; Psychotic disorders