title: Prognostic significance of FLT3-ITD in pediatric acute myeloid leukemia: a meta-analysis of cohort studies.
abstract: The purpose of the study was to assess the effect of the internal tandem duplication in FMS-like tyrosine kinase 3 (FLT3-ITD) on the outcome in pediatric acute myeloid leukemia (AML) patients. We identified eligible studies from several databases including PubMed, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) (from January 1995 to July 2015). Ten studies of 1661 pediatric patients with AML were included in exploring the relationship between the FLT3-ITD and overall survival (OS)/event free survival (EFS). Pediatric patients with AML with FLT3-ITD had worse OS [HR = 2.19 (1.60-3.01)]/EFS [HR = 1.70 (1.37-2.11)] than those patients without FLT3-ITD. Furthermore, FLT3-ITD had unfavorable effect on OS/EFS in the subgroups of NOS, uni/multivariate model, number of patients, the length of following-up, and patient source. The findings of this meta-analysis indicated that FLT3-ITD had negative impact on pediatric patients with AML.
authors.affiliation: Department of Pediatrics, The Second Hospital of Hebei Medical University, No. 215, West Heping Road, Xinhua District, 050000, Shijiazhuang, People's Republic of China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Wu
authors.affiliation: Department of Hematology, The Second Hospital of Hebei Medical University, 050000, Shijiazhuang, People's Republic of China.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Feng
authors.affiliation: Department of Pediatrics, The Second Hospital of Hebei Medical University, No. 215, West Heping Road, Xinhua District, 050000, Shijiazhuang, People's Republic of China.
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Pediatrics, The Second Hospital of Hebei Medical University, No. 215, West Heping Road, Xinhua District, 050000, Shijiazhuang, People's Republic of China.
authors.forename: Futian
authors.initials: F
authors.lastname: Ma
authors.affiliation: Department of Pediatrics, The Second Hospital of Hebei Medical University, No. 215, West Heping Road, Xinhua District, 050000, Shijiazhuang, People's Republic of China.
authors.forename: Na
authors.initials: N
authors.lastname: Liu
authors.affiliation: Department of Pediatrics, The Second Hospital of Hebei Medical University, No. 215, West Heping Road, Xinhua District, 050000, Shijiazhuang, People's Republic of China.
authors.forename: Hongming
authors.initials: H
authors.lastname: Guo
authors.affiliation: Department of Pediatrics, The Second Hospital of Hebei Medical University, No. 215, West Heping Road, Xinhua District, 050000, Shijiazhuang, People's Republic of China.
authors.forename: Chaonan
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Pediatrics, The Second Hospital of Hebei Medical University, No. 215, West Heping Road, Xinhua District, 050000, Shijiazhuang, People's Republic of China.
authors.forename: Huan
authors.initials: H
authors.lastname: Du
authors.affiliation: Department of Pediatrics, The Second Hospital of Hebei Medical University, No. 215, West Heping Road, Xinhua District, 050000, Shijiazhuang, People's Republic of China. zhangbaoxi2008@sina.com.
authors.forename: Baoxi
authors.initials: B
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000201:enzymology / Q000235:genetics / Q000401:mortality; D008297:Male; D008954:Models, Biological; D015996:Survival Rate; D051941:fms-Like Tyrosine Kinase 3 / Q000235:genetics / Q000378:metabolism
chemical_list: C497970:FLT3 protein, human; D051941:fms-Like Tyrosine Kinase 3
keywords: Acute myeloid leukemia; FLT3-ITD; Meta-analysis; Pediatric