title: Hemostatic effect of topical hemocoagulase spray in digestive endoscopy.
abstract: OBJECTIVE
  To evaluate the hemostatic effect of topical hemocoagulase spray in digestive endoscopy.
  
  
  METHODS
  Eighty-nine patients who developed oozing bleeding during endoscopic treatment from September 2014 to October 2014 at Center for Digestive Endoscopy, Tianjin Medical University General Hospital were randomly divided into either a study group (n = 39) or a control group (n = 50). The study group was given topical hemocoagulase spray intraoperatively, while the control group was given traditional 8% norepinephrine spray. Hemostatic efficacy was compared between the two groups. Bleeding site, wound cleanliness and perforation were recorded, and the rates of perforation and late bleeding were compared.
  
  
  RESULTS
  Successful hemostasis was achieved in 39 (100%) patients of the study group and in 47 (94.0%) patients of the control group, and there was no significant difference in the rate of successful hemostasis between the two groups. Compared with the control group, after topical hemocoagulase spray in the study group, the surgical field was clearer, the bleeding site was more easily identified, and the wound was cleaner. There was no significant difference in the rate of perforation between the study and control groups (16.7% vs 35.0%, P = 0.477), but the rates of late bleeding (0% vs 15.8%, P = 0.048) and overall complications (P = 0.032) were significantly lower in the study group.
  
  
  CONCLUSIONS
  Topical hemocoagulase spray has a definite hemostatic effect for oozing bleeding in digestive endoscopy, and this method is convenient, safe, and reliable. It is expected to become a new method for endoscopic hemostasis.
authors.affiliation: Tao Wang, Dan-Na Wang, Wen-Tian Liu, Zhong-Qing Zheng, Xin Chen, Wei-Li Fang, Shu Li, Li Liang, Bang-Mao Wang, Department of Gastroenterology, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.affiliation: Tao Wang, Dan-Na Wang, Wen-Tian Liu, Zhong-Qing Zheng, Xin Chen, Wei-Li Fang, Shu Li, Li Liang, Bang-Mao Wang, Department of Gastroenterology, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Dan-Na
authors.initials: DN
authors.lastname: Wang
authors.affiliation: Tao Wang, Dan-Na Wang, Wen-Tian Liu, Zhong-Qing Zheng, Xin Chen, Wei-Li Fang, Shu Li, Li Liang, Bang-Mao Wang, Department of Gastroenterology, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Wen-Tian
authors.initials: WT
authors.lastname: Liu
authors.affiliation: Tao Wang, Dan-Na Wang, Wen-Tian Liu, Zhong-Qing Zheng, Xin Chen, Wei-Li Fang, Shu Li, Li Liang, Bang-Mao Wang, Department of Gastroenterology, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Zhong-Qing
authors.initials: ZQ
authors.lastname: Zheng
authors.affiliation: Tao Wang, Dan-Na Wang, Wen-Tian Liu, Zhong-Qing Zheng, Xin Chen, Wei-Li Fang, Shu Li, Li Liang, Bang-Mao Wang, Department of Gastroenterology, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.affiliation: Tao Wang, Dan-Na Wang, Wen-Tian Liu, Zhong-Qing Zheng, Xin Chen, Wei-Li Fang, Shu Li, Li Liang, Bang-Mao Wang, Department of Gastroenterology, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Wei-Li
authors.initials: WL
authors.lastname: Fang
authors.affiliation: Tao Wang, Dan-Na Wang, Wen-Tian Liu, Zhong-Qing Zheng, Xin Chen, Wei-Li Fang, Shu Li, Li Liang, Bang-Mao Wang, Department of Gastroenterology, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Shu
authors.initials: S
authors.lastname: Li
authors.affiliation: Tao Wang, Dan-Na Wang, Wen-Tian Liu, Zhong-Qing Zheng, Xin Chen, Wei-Li Fang, Shu Li, Li Liang, Bang-Mao Wang, Department of Gastroenterology, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Li
authors.initials: L
authors.lastname: Liang
authors.affiliation: Tao Wang, Dan-Na Wang, Wen-Tian Liu, Zhong-Qing Zheng, Xin Chen, Wei-Li Fang, Shu Li, Li Liang, Bang-Mao Wang, Department of Gastroenterology, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Bang-Mao
authors.initials: BM
authors.lastname: Wang
mesh_terms: D000287:Administration, Topical; D012103:Batroxobin / Q000627:therapeutic use*; D000069916:Endoscopic Mucosal Resection / Q000379:methods*; D016145:Endoscopy, Digestive System / Q000379:methods; D005260:Female; D016558:Hemostasis, Endoscopic / Q000379:methods*; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D007416:Intestinal Perforation / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000627:therapeutic use; D011183:Postoperative Complications / Q000453:epidemiology; D019106:Postoperative Hemorrhage / Q000453:epidemiology; D016896:Treatment Outcome; D014662:Vasoconstrictor Agents / Q000627:therapeutic use
chemical_list: D006490:Hemostatics; D014662:Vasoconstrictor Agents; D012103:Batroxobin; D009638:Norepinephrine
keywords: Digestive endoscopy; Hemocoagulase; Hemostatic effect; Oozing bleeding; Spray