title: Absolute quantification of myocardial blood flow.
abstract: With the increasing availability of positron emission tomography (PET) myocardial perfusion imaging, the absolute quantification of myocardial blood flow (MBF) has become popular in clinical settings. Quantitative MBF provides an important additional diagnostic or prognostic information over conventional visual assessment. The success of MBF quantification using PET/computed tomography (CT) has increased the demand for this quantitative diagnostic approach to be more accessible. In this regard, MBF quantification approaches have been developed using several other diagnostic imaging modalities including single-photon emission computed tomography, CT, and cardiac magnetic resonance. This review will address the clinical aspects of PET MBF quantification and the new approaches to MBF quantification.
authors.affiliation: Diagnostic and Therapeutic Nuclear Medicine, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-Ku, Chiba, 263-8555, Japan.
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Yoshinaga
authors.affiliation: Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Manabe
authors.affiliation: Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan. natamaki@med.hokudai.ac.jp.
authors.forename: Nagara
authors.initials: N
authors.lastname: Tamaki
mesh_terms: D001783:Blood Flow Velocity; D002309:Cardiology / Q000379:methods; D003326:Coronary Circulation; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D007700:Kinetics; D008279:Magnetic Resonance Imaging; D064847:Multimodal Imaging; D055414:Myocardial Perfusion Imaging; D009206:Myocardium / Q000473:pathology*; D049268:Positron-Emission Tomography; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
keywords: Blood flow; computed tomography; magnetic resonance; positron emission tomography; quantification