title: Association of a promoter polymorphism in FSHR with ovarian reserve and response to ovarian stimulation in women undergoing assisted reproductive treatment.
abstract: Previous studies have suggested an association between a variant in the promoter region of the FSHR gene and diminished response to controlled ovarian hyperstimulation (COH) in women undergoing assisted reproduction. FSHR -29G>A was genotyped in 559 women undergoing their first cycle of COH for IVF/intracytoplasmic sperm injection (ICSI) using TaqMan allelic discrimination assay. Correlation and regression analysis was performed to assess the relationship between FSHR promoter genotypes and markers of ovarian reserve and measures of response to COH, including the number of oocytes retrieved, gonadotrophin dose used and the live-birth rate. There were no statistically significant differences between the genotype frequencies and the markers of ovarian reserve or the early measures of response to COH. However, the live-birth rate was higher for women carrying the variant A allele (odds ratio [OR] 1.37; 95% confidence interval [CI] 1.02-1.84 per allele). This relationship did not reach statistical significance after adjustment for the number of embryos transferred (OR 1.33; 95% CI 0.98-1.83 per allele). Results from this study do not provide evidence that the FSHR -29G>A variant can be used in the individualization of the treatment protocol for women undergoing IVF/ICSI.
authors.affiliation: Manchester Centre for Genomic Medicine, University of Manchester, Manchester, United Kingdom; Clinical Pathology Department, Faculty of Medicine, Mansoura University Mansoura, Egypt.
authors.forename: Dalia
authors.initials: D
authors.lastname: Tohlob
authors.affiliation: Clinical Pathology Department, Faculty of Medicine, Mansoura University Mansoura, Egypt.
authors.forename: Ekbal
authors.initials: E
authors.lastname: Abo Hashem
authors.affiliation: Clinical Pathology Department, Faculty of Medicine, Mansoura University Mansoura, Egypt.
authors.forename: Nawal
authors.initials: N
authors.lastname: Ghareeb
authors.affiliation: Obstetrics and Gynaecology Department, Faculty of Medicine, Mansoura University Mansoura, Egypt.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Ghanem
authors.affiliation: Clinical Pathology Department, Faculty of Medicine, Mansoura University Mansoura, Egypt.
authors.forename: Reham
authors.initials: R
authors.lastname: Elfarahaty
authors.affiliation: Manchester Centre for Genomic Medicine, University of Manchester, Manchester, United Kingdom.
authors.forename: Helen
authors.initials: H
authors.lastname: Byers
authors.affiliation: Department of Clinical Biochemistry, Manchester Royal Infirmary, Manchester, United Kingdom.
authors.forename: Philip
authors.initials: P
authors.lastname: Pemberton
authors.affiliation: Centre for Biostatistics, Institute of Population Health, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester, United Kingdom.
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Roberts
authors.affiliation: Manchester Centre for Genomic Medicine, University of Manchester, Manchester, United Kingdom.
authors.forename: William G
authors.initials: WG
authors.lastname: Newman
authors.affiliation: Department of Reproductive Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom. Electronic address: Lamiya.Mohiyiddeen@cmft.nhs.uk.
authors.forename: Lamiya
authors.initials: L
authors.lastname: Mohiyiddeen
mesh_terms: D000328:Adult; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D016017:Odds Ratio; D065851:Ovarian Reserve / Q000235:genetics*; D010062:Ovulation Induction; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D011962:Receptors, FSH / Q000737:chemistry / Q000235:genetics*; D012044:Regression Analysis; D027724:Reproductive Techniques, Assisted
chemical_list: D011962:Receptors, FSH
keywords: FSHR; IVF; hyperstimulation; ovarian response; polymorphism