title: Combination of ECMO and cytokine adsorption therapy for severe sepsis with cardiogenic shock and ARDS due to Panton-Valentine leukocidin-positive Staphylococcus aureus pneumonia and H1N1.
abstract: Sepsis-induced cardiogenic shock in combination with severe acute respiratory failure represents a life-threatening combination that is often refractory to the conventional methods of treatment. We describe the case of a 33-year-old patient who developed acute cardiovascular collapse and ARDS secondary to superinfection of Panton-Valentine leukocidin-positive Staphylococcus aureus and H1N1 pneumonia who underwent successful combination therapy for severe sepsis-related cardiomyopathy and respiratory failure using extracorporeal membrane oxygenation and cytokine adsorption therapy.
authors.affiliation: Department of Anaesthetic and Critical Care, Harefield Hospital, Royal Brompton & Harefield NHS Foundation Trust, Hill End Road, Harefield, Middlesex, UB9 6JH, UK. n.lees@rbht.nhs.uk.
authors.forename: N J
authors.initials: NJ
authors.lastname: Lees
authors.affiliation: Department of Anaesthetic and Critical Care, Harefield Hospital, Royal Brompton & Harefield NHS Foundation Trust, Hill End Road, Harefield, Middlesex, UB9 6JH, UK.
authors.forename: Ajp
authors.initials: A
authors.lastname: Rosenberg
authors.affiliation: Department of Anaesthetic and Critical Care, Harefield Hospital, Royal Brompton & Harefield NHS Foundation Trust, Hill End Road, Harefield, Middlesex, UB9 6JH, UK.
authors.forename: A I
authors.initials: AI
authors.lastname: Hurtado-Doce
authors.affiliation: Department of Anaesthetic and Critical Care, Harefield Hospital, Royal Brompton & Harefield NHS Foundation Trust, Hill End Road, Harefield, Middlesex, UB9 6JH, UK.
authors.forename: J
authors.initials: J
authors.lastname: Jones
authors.affiliation: Imperial College, London, UK.|Harefield Hospital, Middlesex, UK.|Semmelweis University, Budapest, Hungary.
authors.forename: N
authors.initials: N
authors.lastname: Marczin
authors.affiliation: Department of Cardiothoracic Transplantation and Mechanical Circulatory Support, Harefield Hospital, Royal Brompton & Harefield NHS Foundation Trust, Hill End Road, Harefield, Middlesex, UB9 6JH, UK.
authors.forename: M
authors.initials: M
authors.lastname: Zeriouh
authors.affiliation: Department of Cardiothoracic Transplantation and Mechanical Circulatory Support, Harefield Hospital, Royal Brompton & Harefield NHS Foundation Trust, Hill End Road, Harefield, Middlesex, UB9 6JH, UK.
authors.forename: A
authors.initials: A
authors.lastname: Weymann
authors.affiliation: Department of Cardiothoracic Transplantation and Mechanical Circulatory Support, Harefield Hospital, Royal Brompton & Harefield NHS Foundation Trust, Hill End Road, Harefield, Middlesex, UB9 6JH, UK. a.sabashnikov@gmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Sabashnikov
authors.affiliation: Department of Cardiothoracic Transplantation and Mechanical Circulatory Support, Harefield Hospital, Royal Brompton & Harefield NHS Foundation Trust, Hill End Road, Harefield, Middlesex, UB9 6JH, UK.
authors.forename: A R
authors.initials: AR
authors.lastname: Simon
authors.affiliation: Department of Cardiothoracic Transplantation and Mechanical Circulatory Support, Harefield Hospital, Royal Brompton & Harefield NHS Foundation Trust, Hill End Road, Harefield, Middlesex, UB9 6JH, UK.
authors.forename: A F
authors.initials: AF
authors.lastname: Popov
mesh_terms: D000327:Adsorption; D000328:Adult; D001427:Bacterial Toxins / Q000378:metabolism; D016207:Cytokines / Q000302:isolation & purification*; D005098:Exotoxins / Q000378:metabolism; D015199:Extracorporeal Membrane Oxygenation; D005260:Female; D006464:Hemoperfusion; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000302:isolation & purification; D007251:Influenza, Human / Q000150:complications*; D007956:Leukocidins / Q000378:metabolism; D011023:Pneumonia, Staphylococcal / Q000150:complications* / Q000821:virology; D012128:Respiratory Distress Syndrome / Q000628:therapy / Q000821:virology; D012131:Respiratory Insufficiency / Q000209:etiology; D018805:Sepsis / Q000628:therapy* / Q000821:virology; D012770:Shock, Cardiogenic / Q000628:therapy / Q000821:virology; D013211:Staphylococcus aureus / Q000302:isolation & purification / Q000378:metabolism
chemical_list: D001427:Bacterial Toxins; D016207:Cytokines; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin
keywords: Adsorption therapy; Cytokines; Extracorporeal membrane oxygenation (ECMO); H1N1; Sepsis