title: Rare allergic reaction of the kidney: sitagliptin-induced acute tubulointerstitial nephritis.
abstract: A 56-year-old man with a history of diabetes mellitus type-2 and stage-2 chronic kidney disease secondary to diabetic nephropathy presented with an acute deterioration of kidney function. Non-invasive work-up failed to reveal the underlying aetiology for the acute kidney failure. Kidney biopsy revealed acute tubulointerstitial nephritis (ATIN) which was attributed to sitagliptin use. Only few case reports have shown this correlation. Our aim is to alert physicians and other providers of the potential effect of sitagliptin to cause ATIN with this biopsy-proven case.
authors.affiliation: Department of Internal Medicine, Mayo Clinic Florida, Jacksonville, Florida, USA.
authors.forename: Ali A
authors.initials: AA
authors.lastname: Alsaad
authors.affiliation: Department of Internal Medicine, University of Central Florida, Orlando, Florida, USA.
authors.forename: Sarah M
authors.initials: SM
authors.lastname: Dhannoon
authors.affiliation: Department of Family Medicine, Mayo Clinic, Jacksonville, Florida, USA.
authors.forename: Sally-Ann L
authors.initials: SA
authors.lastname: Pantin
authors.affiliation: Department of Nephrology, Mayo Clinic, Jacksonville, Florida, USA.
authors.forename: Ivan E
authors.initials: IE
authors.lastname: Porter
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications; D001706:Biopsy; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy*; D004342:Drug Hypersensitivity / Q000175:diagnosis*; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D000068900:Sitagliptin Phosphate / Q000009:adverse effects*
chemical_list: D007004:Hypoglycemic Agents; D000068900:Sitagliptin Phosphate