title: Measurement of Mitochondrial Respiration and Motility in Acute Care: Sepsis, Trauma, and Poisoning.
abstract: Metabolic biomarkers have potentially wider use in disease diagnosis and prognosis as well as in monitoring disease response to treatment. While biomarkers such as interleukins, microRNA, and lactate have been proposed for disease surveillance, there are still conflicting results regarding their clinical utility. Treatment of commonly encountered disease of acute care such as sepsis, trauma, and poisoning often relies on clinical diagnosis and therapy guided by use of surrogate markers of illness severity. The measurement of mitochondrial function, including respiration and motility, may offer superior alternatives to such markers. Assessing mitochondrial function in a clinical context has the potential to impact the area of acute care in terms of diagnosis, prognosis, and treatment. The study of mitochondrial bioenergetics has become critical in understanding the pathophysiology and treatment of complex diseases such as diabetes and cardiovascular disorders.
authors.affiliation: Department of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA david.jang@uphs.upenn.edu.
authors.forename: David H
authors.initials: DH
authors.lastname: Jang
authors.affiliation: Department of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.|Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: John C
authors.initials: JC
authors.lastname: Greenwood
authors.affiliation: Department of Emergency Medicine, Section of Medical Toxicology, University of Southern California, Los Angeles, CA, USA.
authors.forename: Meghan B
authors.initials: MB
authors.lastname: Spyres
authors.affiliation: Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, USA.|Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA, USA.|Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: David M
authors.initials: DM
authors.lastname: Eckmann
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D019069:Cell Respiration; D003422:Critical Care; D016638:Critical Illness / Q000628:therapy*; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D008991:Monitoring, Physiologic; D011041:Poisoning / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy; D017382:Reactive Oxygen Species / Q000378:metabolism; D018805:Sepsis / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy; D014947:Wounds and Injuries / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy
chemical_list: D015415:Biomarkers; D017382:Reactive Oxygen Species
keywords: bioenergetics; medical toxicology; mitochondria; mitochondrial motility; resuscitation; sepsis