title: TRANEXAMIC ACID ACTION ON LIVER REGENERATION AFTER PARTIAL HEPATECTOMY: EXPERIMENTAL MODEL IN RATS.
abstract: Different lesions may affect the liver resulting in harmful stimuli. Some therapeutic procedures to treat those injuries depend on liver regeneration to increase functional capacity of this organ.
  
  
  
  Evaluate the effects of tranexamic acid on liver regeneration after partial hepatectomy in rats.
  
  
  
  40 rats (Rattus norvegicus albinus, Rodentia mammalia) of Wistar-UP lineage were randomly divided into two groups named control (CT) and tranexamic acid (ATX), with 20 rats in each. Both groups were subdivided, according to liver regeneration time of 32 h or seven days after the rats had been operated. The organ regeneration was evaluated through weight and histology, stained with HE and PCNA.
  
  
  
  The average animal weight of ATX and CT 7 days groups before surgery were 411.2 g and 432.7 g, and 371.3 g and 392.9 g after the regeneration time, respectively. The average number of mitotic cells stained with HE for the ATX and CT 7 days groups were 33.7 and 32.6 mitosis, and 14.5 and 14.9 for the ATX and CT 32 h groups, respectively. When stained with proliferating cell nuclear antigen, the numbers of mitotic cells counted were 849.7 for the ATX 7 days, 301.8 for the CT 7 days groups, 814.2 for the ATX 32 hand 848.1 for the CT 32 h groups.
  
  
  
  Tranexamic acid was effective in liver regeneration, but in longer period after partial hepatectomy.
authors.affiliation: Postgraduate Program in Principles of Surgery, Evangelic Faculty of Paraná/University Evangelic Hospital of Curitiba/Medical Research Institute.
authors.forename: Felipe Antonio
authors.initials: FA
authors.lastname: Sobral
authors.affiliation: Postgraduate Program in Principles of Surgery, Evangelic Faculty of Paraná/University Evangelic Hospital of Curitiba/Medical Research Institute.
authors.forename: Henrique
authors.initials: H
authors.lastname: Daga
authors.affiliation: Postgraduate Program in Principles of Surgery, Evangelic Faculty of Paraná/University Evangelic Hospital of Curitiba/Medical Research Institute.
authors.forename: Henrique Nogueira
authors.initials: HN
authors.lastname: Rasera
authors.affiliation: Postgraduate Program in Principles of Surgery, Evangelic Faculty of Paraná/University Evangelic Hospital of Curitiba/Medical Research Institute.
authors.forename: Matheus da Rocha
authors.initials: Mda R
authors.lastname: Pinheiro
authors.affiliation: Postgraduate Program in Principles of Surgery, Evangelic Faculty of Paraná/University Evangelic Hospital of Curitiba/Medical Research Institute.
authors.forename: Igor Furlan
authors.initials: IF
authors.lastname: Cella
authors.affiliation: Postgraduate Program in Principles of Surgery, Evangelic Faculty of Paraná/University Evangelic Hospital of Curitiba/Medical Research Institute.
authors.forename: Igor Henrique
authors.initials: IH
authors.lastname: Morais
authors.affiliation: Postgraduate Program in Principles of Surgery, Evangelic Faculty of Paraná/University Evangelic Hospital of Curitiba/Medical Research Institute.
authors.forename: Luciana de Oliveira
authors.initials: Lde O
authors.lastname: Marques
authors.affiliation: Nossa Senhora das Graças Hospital, Curitiba, PR, Brazil.
authors.forename: Luiz Martins
authors.initials: LM
authors.lastname: Collaço
mesh_terms: D000818:Animals; D006498:Hepatectomy / Q000379:methods*; D008115:Liver Regeneration / Q000187:drug effects*; D008297:Male; D023421:Models, Animal; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D014148:Tranexamic Acid / Q000494:pharmacology*
chemical_list: D014148:Tranexamic Acid