title: Neuroprotective and Anti-Inflammatory Effects of Diphenylheptanes from the Fruits of Amomum tsaoko, a Chinese Spice.
abstract: Two novel diphenylheptanes, 2,3- dihydro-2 - (4' - hydroxy-phenylethyl) - 6 - [(3″,4″ - dihydroxy-5" - methoxy) phenyl] -4 - pyrone (CG-A) and 4 - dihydro-2 - (4' - hydroxy-phenylmethyl) -6 - [(3",4″ - dihydroxy-5″ - methoxyphenyl) methylene]-pyran-3, 5 - dione (CG-B), were isolated from the dried fruits of Amomum tsaoko, a commercially important spice. This study was designed to investigate their protective effects against H2O2-induced nerve injury, using PC-12 cells to determine the cell cytotoxicity and cell viability. The inhibitory effect on (nitric oxide) NO production was also determined in (lipopolysaccharide) LPS-stimulated macrophage RAW 264.7 cells. The results showed that CG-A and CG-B displayed significant neuroprotective effect and exhibited anti-inflammatory activity in a dose-dependent manner. These findings suggest that CG-A and CG-B are very important nutritional ingredients responsible for the neuroprotective and anti-inflammatory health benefits of A. tsaoko.
authors.affiliation: School of Food Science and Engineering, South China University of Technology, Guangzhou, 510640, China.
authors.forename: Tian-Tian
authors.initials: TT
authors.lastname: Zhang
authors.affiliation: School of Food Science and Engineering, South China University of Technology, Guangzhou, 510640, China.|Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Menglun, Mengla, Yunnan, 666303, China.
authors.forename: Chuan-Li
authors.initials: CL
authors.lastname: Lu
authors.affiliation: School of Food Science and Engineering, South China University of Technology, Guangzhou, 510640, China. jgjiang@scut.edu.cn.
authors.forename: Jian-Guo
authors.initials: JG
authors.lastname: Jiang
mesh_terms: D035801:Amomum / Q000737:chemistry*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D002396:Catechols / Q000737:chemistry / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D005638:Fruit / Q000737:chemistry*; D006536:Heptanes / Q000737:chemistry / Q000494:pharmacology*; D006861:Hydrogen Peroxide / Q000633:toxicity; D008070:Lipopolysaccharides / Q000633:toxicity; D008264:Macrophages / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D018696:Neuroprotective Agents / Q000737:chemistry / Q000494:pharmacology*; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D016716:PC12 Cells; D011753:Pyrones / Q000737:chemistry / Q000494:pharmacology; D000067996:RAW 264.7 Cells; D051381:Rats; D017365:Spices / Q000032:analysis*
chemical_list: C000616893:2,3-dihydro-2-(4'-hydroxyphenylethyl)-6-((3',4'- dihydroxy-5'-methoxy)phenyl)-4-pyrone; C000616894:4-dihydro-2-(4'-hydroxyphenylmethyl)-6-((3',4'-dihydroxy-5'-methoxyphenyl)methylene)pyran-3,5-dione; D000893:Anti-Inflammatory Agents; D002396:Catechols; D006536:Heptanes; D008070:Lipopolysaccharides; D018696:Neuroprotective Agents; D011753:Pyrones; D009569:Nitric Oxide; D006861:Hydrogen Peroxide
keywords: Amomum tsaoko; Anti-inflammatory; Diphenylheptanes; Neuroprotective effect