title: Apneic events - A proposed new target for respiratory safety pharmacology.
abstract: Current practice in respiratory safety pharmacology generally follows the regulatory guidance provided by the ICH document S7A and focuses on measures of pulmonary ventilation. What these measures do not account for is the ability of drugs to cause ventilatory instability or interruptions in ventilatory rhythm. Ventilatory instability can be identified by the presence of prolonged end-expiratory pauses or apneic periods. An apneic event has been defined as an apneic period of sufficient duration to cause hypoxia (i.e., decrease in hemoglobin oxygen saturation ≥ 3%). Repeated apneic events are often referred to as intermittent hypoxia. Characterizing ventilatory instability is important since (1) occurrence of apneic events in humans can lead to serious adverse outcomes such as systemic and pulmonary hypertension, cardiac arrhythmia, stroke, CNS dysfunction, metabolic disorders, enhanced tumor growth and death, (2) drugs are known to cause or exacerbate apneic events in humans, and (3) there is a preexisting condition of ventilatory instability referred to as sleep apnea that is prevalent in the human population. Evaluating this new target in respiratory safety pharmacology studies is needed to ensure that the potential for new drugs to cause or exacerbate apneic events can be identified and the impact on patient safety characterized.
authors.affiliation: Department of Safety Pharmacology, GlaxoSmithKline Pharmaceuticals, King of Prussia, PA, USA. Electronic address: murphyphddabt@gmail.com.
authors.forename: Dennis J
authors.initials: DJ
authors.lastname: Murphy
mesh_terms: D000818:Animals; D004285:Dogs; D006801:Humans; D000860:Hypoxia / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D012123:Pulmonary Ventilation / Q000187:drug effects*; D012119:Respiration / Q000187:drug effects*; D012449:Safety; D020181:Sleep Apnea, Obstructive / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology*
chemical_list: D004364:Pharmaceutical Preparations
keywords: Apnea; Apneic event; Drug safety; ICHS7A; Intermittent hypoxia; Respiratory; Safety pharmacology; Sleep apnea; Ventilatory instability