title: Fabrication of an Interlocked Antibiotic/Cement-Coated Carbon Fiber Nail for the Treatment of Long Bone Osteomyelitis.
abstract: Successful management of intramedullary long bone osteomyelitis remains a challenge for both surgeons and patients. Patients are often immune compromised and have endured multiple surgeries. Treatment principles include antibiotic administration (systemically ± locally), surgical debridement of the infection site, and stabilization. Since their description in 2002, antibiotic-coated nails have become part of the armamentarium for the treatment of osteomyelitis allowing both local elution of antibiotics and stabilization of a debrided long bone. Limitations to their utilization have remained, in part from the technical difficulty of fabrication and magnetic resonance imaging artifacts. We describe a new surgical technique of fabrication that has the advantages of being simple, reproducible, with an end product free of magnetic resonance imaging artifacts.
authors.affiliation: *Department of Orthopaedic Surgery, Denver Health Medical Center, University of Colorado, School of Medicine, Denver, CO; and †Department of Orthopaedics, University of Michigan, MI.
authors.forename: Cyril
authors.initials: C
authors.lastname: Mauffrey
authors.forename: Nathan
authors.initials: N
authors.lastname: Butler
authors.forename: Mark E
authors.initials: ME
authors.lastname: Hake
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D019072:Antibiotic Prophylaxis / Q000379:methods*; D001843:Bone Cements / Q000627:therapeutic use*; D001858:Bone Nails; D002244:Carbon / Q000737:chemistry; D000077482:Carbon Fiber; D020099:Coated Materials, Biocompatible / Q000008:administration & dosage; D003131:Combined Modality Therapy / Q000295:instrumentation / Q000379:methods; D003646:Debridement / Q000295:instrumentation / Q000379:methods; D004343:Drug Implants / Q000008:administration & dosage*; D019544:Equipment Failure Analysis; D019317:Evidence-Based Medicine; D006801:Humans; D010019:Osteomyelitis / Q000628:therapy*; D011474:Prosthesis Design; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D001843:Bone Cements; D000077482:Carbon Fiber; D020099:Coated Materials, Biocompatible; D004343:Drug Implants; D002244:Carbon