title: Intricate Assessment and Evaluation of Dental Implants in Patients on Bisphosphonate Therapy: A Retrospective Analysis.
abstract: BACKGROUND
  Osteonecrosis is one of the prevalent side effects of bisphosphonate (BP) therapy in oral cancer patients. In case of patients with various oncologic lesions, standard guidelines contraindicate the use of dental implants if the patients are on BP therapy. Literature also quotes studies that emphasize on the safety of dental implants in patients on BP therapy. Hence, this study aimed to retrospectively evaluate the clinical outcome of dental implants in patients on BP therapy.
  
  
  METHODS
  In this retrospective analysis, a total of 140 dental implants in 112 patients were included. Inclusion criteria included only those patients who were on or had history of BP therapy. Calculation of implant failure and survival rate was done.
  
  
  RESULTS
  Ten cases of implant failure occurred, giving a success rate of above 92%, which was comparable to the results found in previous studies in patients who were not on BP therapy.
  
  
  CONCLUSIONS
  No significant risk of implant failure is seen in patients on BP therapy compared with other patients.
authors.affiliation: Professor, Department of Prosthodontics, Shree Bankey Bihari Dental College and Research Centre, Ghaziabad, Uttar Pradesh, India, e-mail: drsuraj@hotmail.com.
authors.forename: Suraj
authors.initials: S
authors.lastname: Suvarna
authors.affiliation: Department of Periodontics, Shree Bankey Bihari Dental College and Research Centre, Ghaziabad, Uttar Pradesh, India.
authors.forename: Poonam
authors.initials: P
authors.lastname: Dutt
authors.affiliation: Department of Prosthodontics, Shree Bankey Bihari Dental College and Research Centre, Ghaziabad, Uttar Pradesh, India.
authors.forename: Animesh
authors.initials: A
authors.lastname: Misra
authors.affiliation: Department of Prosthodontics, Shree Bankey Bihari Dental College and Research Centre, Ghaziabad, Uttar Pradesh, India.
authors.forename: Nausheen
authors.initials: N
authors.lastname: Usmani
authors.affiliation: Department of Prosthodontics, Sudha Rustagi College of Dental Sciences and Research, Faridabad, Haryana, India.
authors.forename: Abhishek
authors.initials: A
authors.lastname: Singh
authors.affiliation: Private Practice, New Delhi, India.
authors.forename: Chandini
authors.initials: C
authors.lastname: Suvarna
mesh_terms: D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D019232:Dental Restoration Failure; D004164:Diphosphonates / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007571:Jaw Diseases; D008297:Male; D016348:Osseointegration; D010020:Osteonecrosis / Q000139:chemically induced; D012189:Retrospective Studies
chemical_list: D015921:Dental Implants; D004164:Diphosphonates
keywords: Bisphosphonate; Implants; Osteonecrosis of the jaws.