title: Multiresidual LC-MS analysis of plasticizers used in PVC gaskets of lids and assessment of their migration into food sauces.
abstract: Plasticizers may migrate from polyvinyl chloride (PVC) gaskets into the foodstuffs mainly by direct contact during the packaging and sterilization procedure, but also by means of occasional contacts occurring during shipment and storage. The present work reports a reliable liquid chromatography-mass spectrometry (LC-MS) method able to quantify the main plasticizers used in the PVC closure gaskets for metal lids to verify their compliance in both food contact materials and foodstuffs. The atmospheric pressure chemical ionization in the positive ion mode resulted the best performing interface for the multiresidual detection of the plasticizers taken into account, followed by selected/multiple reaction monitoring, selected ion monitoring or full scan experiments, depending on the compounds to detect. The method was single-laboratory validated, demonstrating to reach a good sensitivity, thus making possible to perform analysis without any preliminary sample purification or concentration step. It proved to be effectively applicable not only for the determination of plasticizers in PVC gaskets but also in complex food matrices. In particular, it was applied for monitoring plasticizer migration into sauces placed in contact with the lids in worst storage conditions, observing therefore their trend during the shelf-life. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Advanced Laboratory Research, Barilla G. R. F.lli SpA, via Mantova 166, 43122, Parma, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Lambertini
authors.affiliation: Advanced Laboratory Research, Barilla G. R. F.lli SpA, via Mantova 166, 43122, Parma, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Catellani
authors.affiliation: Advanced Laboratory Research, Barilla G. R. F.lli SpA, via Mantova 166, 43122, Parma, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Vindigni
authors.affiliation: Advanced Laboratory Research, Barilla G. R. F.lli SpA, via Mantova 166, 43122, Parma, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Suman
mesh_terms: D002853:Chromatography, Liquid / Q000379:methods; D005506:Food Contamination / Q000032:analysis*; D018857:Food Packaging; D016014:Linear Models; D013058:Mass Spectrometry / Q000379:methods*; D010968:Plasticizers / Q000032:analysis*; D011143:Polyvinyl Chloride / Q000032:analysis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D010968:Plasticizers; D011143:Polyvinyl Chloride
keywords: LC-MS; PVC gaskets; food contact materials; food sauces; metal lids; migration; plasticizers; polyadipates