title: Long-term effectiveness of levodopa-carbidopa intestinal gel in 177 Spanish patients with advanced Parkinson's disease.
abstract: To assess long-term effectiveness and tolerability of levodopa-carbidopa intestinal gel (LCIG) in Spanish patients with advanced Parkinson's disease.
  
  
  
  This was an observational, multicenter, cross-sectional, retrospective study.
  
  
  
  Data of 177 patients were analyzed. LCIG treatment led to a reduction in the percentage of daily 'off' time (16.2 vs 47.6% before LCIG), an increase in the percentage of daily 'on' time without disabling dyskinesia (55.6 vs 21.6%). Most patients experienced improvements in freezing of gait, tremor, dizziness, fatigue or flat mood. Adverse events related to levodopa, gastrostomy and technical issues were reported in 36.2, 42.4 and 43.5% of patients, respectively.
  
  
  
  This study confirms the long-term effectiveness and safety profile of LCIG in patients with advanced Parkinson's disease.
authors.affiliation: Movement Disorders Unit, Neurology Department, Hospital Clínic, Carrer Villarroel, 170, 08036 Barcelona, Spain.
authors.forename: Francesc
authors.initials: F
authors.lastname: Valldeoriola
authors.affiliation: Neurology Department, Hospital General Universitario Gregorio Marañón, Calle del Doctor Esquerdo 46, 28007 Madrid, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Grandas
authors.affiliation: Neurology Section, Internal Medicine Department, Hospital Arquitecto Marcide, Complejo Hospitalario Universitario de Ferrol (CHUF), Av. Residencia s/n, 15405 Ferrol, A Coruña, Spain.
authors.forename: Diego
authors.initials: D
authors.lastname: Santos-García
authors.affiliation: Functional Neurosugery Unit, Hospital Universitario Ramón y Cajal, Carretera Colmenar km 9,100, 28034 Madrid, Spain.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Regidor
authors.affiliation: Neurology Department, Hospital Clínico San Carlos, Profesor Martín Lagos, S/N, 28040 Madrid, Spain.
authors.forename: María José
authors.initials: MJ
authors.lastname: Catalán
authors.affiliation: Neurology Department, Hospital Universitario Insular de Gran Canaria, Avenida Marítima del Sur, s/n, 35016 Las Palmas de Gran Canaria, Spain.
authors.forename: José Matías
authors.initials: JM
authors.lastname: Arbelo
authors.affiliation: Movement Disorders Unit, Neurology Department, Parc de Salut Mar, Institut Municipal d'Investigació Medica Hospital del Mar, Universitat Autònoma de Barcelona, Passeig Marítim, 25-29, 08003 Barcelona, Spain.
authors.forename: Víctor
authors.initials: V
authors.lastname: Puente
authors.affiliation: Movement Disorders Unit, Neurology Department, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Av. Manuel Siurot, s/n, 41013 Sevilla, Spain.|Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Campus de Cantoblanco, 28049 Madrid, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Mir
authors.affiliation: AbbVie Spain S.L.U. Avenida De Burgos 91, 28050 Madrid, Spain.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Parra
mesh_terms: D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use*; D002230:Carbidopa / Q000627:therapeutic use*; D003430:Cross-Sectional Studies; D004338:Drug Combinations; D005260:Female; D005782:Gels / Q000627:therapeutic use*; D006801:Humans; D007422:Intestines / Q000502:physiology; D007980:Levodopa / Q000627:therapeutic use*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000187:drug effects; D010300:Parkinson Disease / Q000188:drug therapy* / Q000503:physiopathology; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013030:Spain
chemical_list: D000978:Antiparkinson Agents; D004338:Drug Combinations; D005782:Gels; C009265:carbidopa, levodopa drug combination; D007980:Levodopa; D002230:Carbidopa
keywords: Parkinson's disease; dyskinesia; levodopa–carbidopa intestinal gel; nonmotor symptoms; ‘off’ time