title: Cationic Polymeric Nanocapsules as a Strategy to Target Dexamethasone to Viable Epidermis: Skin Penetration and Permeation Studies.
abstract: The present work aimed to evaluate the behavior of dexamethasone-loaded cationic polymericnanocapsules in hydrogels, regarding their in vitro drug release and skin drug retention and per- meation. Cationic polymeric nanocapsules prepared with Eudragit RS 100 as the polymeric wall had mean particle size of 139 +/- 3.6 nm, positive zeta potential (+11.38 +/- 1.7 mV), and high encapsulation efficiency (81 +/- 2%). After preparation, they were formulated as hydrogels, which showed non-Newtonian, plastic behavior, and acidic pH. Photon correlation spectroscopy analysis of these hydrogels demonstrated the presence of particles with mean particle size close to that of the original colloidal suspensions. The presence of dexamethasone-loaded nanocapsules in hydrogels promoted controlled drug release and an increase in the amount of drug delivered into viable epidermis, the main target tissue to topical glucocorticoid action. Moreover, the formulation did not increase the risk of drug penetration to dermis and permeation to the receptor compartment.
authors.forename: Tiago Costa
authors.initials: TC
authors.lastname: Beber
authors.forename: Diego Fontana
authors.initials: DF
authors.lastname: de Andrade
authors.forename: Paula dos Santos
authors.initials: Pdos S
authors.lastname: Chaves
authors.forename: Adriana Raffin
authors.initials: AR
authors.lastname: Pohlmann
authors.forename: Silvia Stanisquaski
authors.initials: SS
authors.lastname: Guterres
authors.forename: Ruy Carlos Ruver
authors.initials: RC
authors.lastname: Beck
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D000818:Animals; D003907:Dexamethasone / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D004817:Epidermis / Q000378:metabolism*; D005260:Female; D006863:Hydrogen-Ion Concentration; D053769:Nanocapsules / Q000737:chemistry*; D010316:Particle Size; D010539:Permeability; D013552:Swine
chemical_list: D000180:Acrylic Resins; D053769:Nanocapsules; C050528:Eudragit RS; D003907:Dexamethasone