title: Histological Evaluation of the Effect of Concentrated Growth Factor on Bone Healing.
abstract: OBJECTIVE
  The aim of this study was to evaluate the effects of concentrated growth factors (CGF) on the healing of peri-implant bone defects in an animal model.
  
  
  METHODS
  Twenty 4-month-old New Zealand White rabbits, each with an average weight of 3.5 kg, were used in this blinded, prospective, experimental study. Two implants were placed and 2 peri-impant defects were prepared in each rabbit tibia. Bone defects were created monocortically in the tibia of each rabbit using a trephine burr with a diameter of 8 mm. The implants were installed in each hole. The rabbits were divided into 4 groups: in group E, the defect was left empty; in group CGF, the defects were filled only with CGF; in group AB, the defects were filled with autogenous bone; and in group AB+CGF, the defects were filled with autogenous bone and CGF. The animals were euthanized at week 8 postimplantation. All implants from the 20 animals were fixed in 10% formalin and evaluated histomorphometrically.
  
  
  RESULTS
  The mean defect area was highest in group E and lowest in group CGF+AB (P <0.05). The area of the defect differed significantly between groups AB and CGF+AB (P <0.05), but not between groups CGF and E. Implant-to-bone contact was lowest in group E. In the defect areas of groups CGF, AB and CGF+AB, a small amount of new bone formed around the implant.
  
  
  CONCLUSIONS
  In this animal model of a peri-implant bone defect, restoration was achieved using a combination of autogenous bone and CGF. Further studies are needed to determine the behavior of CGF when used in the repair of bone defects in humans.
authors.affiliation: *Department of Oral and Maxillofacial Surgery †Department of Periodontology, Faculty of Dentistry, Bülent Ecevit University ‡Department of Periodontology, Faculty of Dentistry, Ordu University, Zonguldak §Department of Oral Pathology, Faculty of Dentistry, Gazi University, Ankara ||Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Cukurova University, Adana ¶Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gazi University, Ankara, Turkey.
authors.forename: Mustafa Cenk
authors.initials: MC
authors.lastname: Durmuşlar
authors.forename: Umut
authors.initials: U
authors.lastname: Balli
authors.forename: Figen Öngöz
authors.initials: FÖ
authors.lastname: Dede
authors.forename: Ahmet Ferhat
authors.initials: AF
authors.lastname: Misir
authors.forename: Emre
authors.initials: E
authors.lastname: Bariş
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kürkçü
authors.forename: Sevil Altindağ
authors.initials: SA
authors.lastname: Kahraman
mesh_terms: D000818:Animals; D017102:Fracture Healing / Q000187:drug effects*; D036341:Intercellular Signaling Peptides and Proteins / Q000494:pharmacology*; D011446:Prospective Studies; D011817:Rabbits; D013977:Tibia / Q000187:drug effects / Q000293:injuries / Q000473:pathology
chemical_list: D036341:Intercellular Signaling Peptides and Proteins