title: Synthesis of α-Fluoroketones by Insertion of HF into a Gold Carbene.
abstract: Reported is an efficient synthesis of α-fluoroketones by insertion of hydrogen fluoride (HF) into the gold carbene intermediate, generated from a cationic gold catalyzed addition of N-oxides to alkynes. This method results in excellent chemical yields for a wide range of alkyne substrates and demonstrates good functional-group tolerance.
authors.affiliation: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Lu, Shanghai, 201620, China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Zeng
authors.affiliation: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Lu, Shanghai, 201620, China.
authors.forename: Shiwen
authors.initials: S
authors.lastname: Liu
authors.affiliation: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Lu, Shanghai, 201620, China.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Shi
authors.affiliation: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Lu, Shanghai, 201620, China.
authors.forename: Guangchang
authors.initials: G
authors.lastname: Liu
authors.affiliation: College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Lu, Shanghai, 201620, China. bo.xu@dhu.edu.cn.
authors.forename: Bo
authors.initials: B
authors.lastname: Xu
keywords: carbenes; fluorine; gold; nitrogen oxides; reaction mechanisms