title: Humanized mice for HIV and AIDS research.
abstract: HIV has a very limited species tropism that prevents the use of most conventional small animal models for AIDS research. The in vivo analysis of HIV/AIDS has benefited extensively from novel chimeric animal models that accurately recapitulate key aspects of the human condition. Specifically, immunodeficient mice that are systemically repopulated with human hematolymphoid cells offer a viable alternative for the study of a multitude of highly relevant aspects of HIV replication, pathogenesis, therapy, transmission, prevention, and eradication. This article summarizes some of the multiple contributions that humanized mouse models of HIV infection have made to the field of AIDS research. These models have proven to be highly informative and hold great potential for accelerating multiple aspects of HIV research in the future.
authors.affiliation: Division of Infectious Diseases, UNC Center for AIDS Research, University of North Carolina School of Medicine, Genetic Medicine Building, Rm. 2043, Chapel Hill, NC 27599-7042, United States. Electronic address: Victor_garcia@med.unc.edu.
authors.forename: J
authors.initials: J
authors.lastname: Victor Garcia
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000821:virology; D000818:Animals; D030801:Animals, Genetically Modified; D035843:Biomedical Research; D004195:Disease Models, Animal; D015658:HIV Infections / Q000276:immunology / Q000821:virology; D015497:HIV-1 / Q000502:physiology; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D051379:Mice / Q000235:genetics; D016513:Mice, SCID