title: Is Angiosome-Targeted Angioplasty Effective for Limb Salvage and Wound Healing in Diabetic Foot? : A Meta-Analysis.
abstract: OBJECTIVE
  Given that the efficacy of employing angiosome-targeted angioplasty in the treatment of diabetic foot remains controversial, this study was conducted to examine its efficacy.
  
  
  METHODS
  We performed a systematic literature review and meta-analysis using core databases, extracting the treatment modality of angiosome-targeted angioplasty as the predictor variable, and limb salvage, wound healing, and revision rate as the outcome variables. We used the Newcastle-Ottawa Scale to assess the study quality, along with the Cochrane Risk of Bias Tool. We evaluated publication bias using a funnel plot.
  
  
  RESULTS
  The search strategy identified 518 publications. After screening these, we selected four articles for review. The meta-analysis revealed that overall limb salvage and wound healing rates were significantly higher (Odds ratio = 2.209, 3.290, p = 0.001, p<0.001) in patients who received angiosome-targeted angioplasty than in those who received nonangiosome-targeted angioplasty. The revision rate between the angiosome and nonangiosome groups was not significantly different (Odds ratio = 0.747, p = 0.314).
  
  
  CONCLUSIONS
  Although a further randomized controlled trial is required for confirmation, angiosome-targeted angioplasty in diabetic foot was more effective than nonangiosome-targeted angioplasty with respect to wound healing and limb salvage.
authors.affiliation: Department of Radiology, Chonbuk National University Hospital, Jeonju, Korea.
authors.forename: Kum Ju
authors.initials: KJ
authors.lastname: Chae
authors.affiliation: Department of Plastic and Reconstructive Surgery, Chonbuk National University Hospital, Jeonju, Korea.
authors.forename: Jin Yong
authors.identifier: http://orcid.org/0000-0003-2680-7411
authors.initials: JY
authors.lastname: Shin
mesh_terms: D000368:Aged; D017130:Angioplasty; D001808:Blood Vessels / Q000473:pathology*; D017719:Diabetic Foot / Q000473:pathology* / Q000628:therapy*; D006801:Humans; D023821:Limb Salvage; D008875:Middle Aged; D017594:Publication Bias; D014945:Wound Healing