title: [An Elderly Patient with Multiple Lung Metastases after Colectomy Successfully Treated with a Combination Oral UFT/LV Chemotherapy Regimen].
abstract: We report an 84-year-old woman with multiple lung metastases from sigmoid colon cancer successfully treated with an oral combination chemotherapeutic agent regimen(UFT/LV).The patient had undergone colectomy for sigmoid colon cancer. Histological examination confirmed a pT4a, pN3, pM1a(LYM), pStage IV tumor.The patient refused adjuvant chemotherapy. However, approximately 9 months postoperatively, she developed a severe cough.Chest radiography and computed tomography(CT)revealed multiple progressive lung metastases.Thereafter, considering her advanced age and general condition, an oral UFT/LV regimen(UFT 300mg/LV 75mg for 7 days every 14 days)was initiated.Two and a half months after initiating chemotherapy, symptom amelioration was observed.Chest radiography and CT showed disappearance of several of the lung metastases, indicating a Partial Response(PR).For the nearly one year to date since diagnosis, she has remained free of cough and the PR has been maintained without chemotherapy-associated adverse events.She is currently being managed on an outpatient basis.The oral UFT/LV regimen is considered to be among the potentially effective and safe treatments for elderly patients with postoperative metastases from colon cancer.
authors.affiliation: Dept. of Surgery, National Defense Medical College Hospital.
authors.forename: Takehiro
authors.initials: T
authors.lastname: Shiraishi
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Moriya
authors.forename: Hideki
authors.initials: H
authors.lastname: Ueno
authors.forename: Eiji
authors.initials: E
authors.lastname: Shinto
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Kajiwara
authors.forename: Takahiro
authors.initials: T
authors.lastname: Sueyama
authors.forename: Tomoki
authors.initials: T
authors.lastname: Watanabe
authors.forename: Masato
authors.initials: M
authors.lastname: Yamadera
authors.forename: Junji
authors.initials: J
authors.lastname: Yamamoto
authors.forename: Kazuo
authors.initials: K
authors.lastname: Hase
mesh_terms: D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003082:Colectomy; D005260:Female; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary; D012811:Sigmoid Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D005641:Tegafur / Q000008:administration & dosage; D016896:Treatment Outcome; D014498:Uracil / Q000008:administration & dosage
chemical_list: D005641:Tegafur; D014498:Uracil; D002955:Leucovorin