title: Early Bronchus-Associated Lymphoid Tissue Lymphoma Diagnosed with Immunoglobulin Heavy Chain Molecular Testing.
abstract: When extranodal marginal zone B-cell lymphoma of mucosa associated lymphoid tissue (MALT), a low grade B-cell lymphoma, arises in the lung it is referred to as bronchus-associated lymphoid tissue (BALT) lymphoma. We describe a patient with a history of Sjögren's syndrome and rheumatoid arthritis with dyspnea and imaging consistent with lymphoid interstitial pneumonia (LIP). However, while histology and immunohistochemistry lacked definitive features of a lymphoma, immunoglobulin heavy chain (IgH) polymerase chain reaction testing demonstrated B-cell monoclonality, consistent with an early BALT lymphoma.
authors.affiliation: Department of Medicine, University of Alberta, Edmonton, AB, Canada T6G 2G3.
authors.forename: Pen
authors.identifier: 0000-0001-7815-741X
authors.initials: P
authors.lastname: Li
authors.affiliation: Department of Medicine, University of Alberta, Edmonton, AB, Canada T6G 2G3; Division of Critical Care Medicine, University of Alberta, Edmonton, AB, Canada T6G 2G3.
authors.forename: Lawrence
authors.initials: L
authors.lastname: Cheung
authors.affiliation: Department of Laboratory-Medicine and Pathology, University of Alberta, Edmonton, AB, Canada T6G 2B7.
authors.forename: Brian
authors.initials: B
authors.lastname: Chiu
mesh_terms: D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy; D001984:Bronchial Neoplasms / Q000150:complications / Q000000981:diagnostic imaging* / Q000235:genetics / Q000473:pathology; D003371:Cough / Q000209:etiology; D004417:Dyspnea / Q000209:etiology; D005260:Female; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain / Q000235:genetics; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D000069285:Infliximab / Q000627:therapeutic use; D018442:Lymphoma, B-Cell, Marginal Zone / Q000150:complications / Q000000981:diagnostic imaging* / Q000235:genetics / Q000473:pathology; D016133:Polymerase Chain Reaction; D012859:Sjogren's Syndrome / Q000150:complications / Q000188:drug therapy; D014057:Tomography, X-Ray Computed
chemical_list: D007143:Immunoglobulin Heavy Chains; D000069285:Infliximab