title: A mitochondrial-derived vesicle HOPS to endolysosomes using Syntaxin-17.
abstract: Damaged mitochondrial content is packaged in mitochondrial-derived vesicles (MDVs), which are targeted for degradation through an unclear mechanism. McLelland et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201603105) show that the SNARE Syntaxin-17 mediates MDV fusion with endolysosomes, promoting the delivery of mitochondrial cargo to lysosomes for degradation.
authors.affiliation: Institute of Genetics, Biological Research Center of the Hungarian Academy of Sciences, Szeged, H-6726 Hungary Department of Anatomy, Cell, and Developmental Biology, Eötvös Loránd University, Budapest, H-1117 Hungary szmrt@elte.hu.
authors.forename: Gábor
authors.initials: G
authors.lastname: Juhász
mesh_terms: D000818:Animals; D022162:Cytoplasmic Vesicles / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism; D011992:Endosomes / Q000378:metabolism*; D006801:Humans; D008247:Lysosomes / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000378:metabolism; D008954:Models, Biological; D046912:Multiprotein Complexes / Q000378:metabolism*; D010300:Parkinson Disease / Q000378:metabolism / Q000473:pathology; D010588:Phagosomes / Q000378:metabolism; D050765:Qa-SNARE Proteins / Q000378:metabolism*; D050600:SNARE Proteins / Q000378:metabolism
chemical_list: D024101:Mitochondrial Proteins; D046912:Multiprotein Complexes; D050765:Qa-SNARE Proteins; D050600:SNARE Proteins