title: Routine Hemostasis and Hemogram Parameters: Valuable Assessments for Coagulation Disorder and Chemotherapy in Cancer Patients.
abstract: BACKGROUND
  The clotting system abnormalities are the common complication in cancer patients. The aim of this retrospective study was to evaluate the coagulation state, clinical features, and treatment in cancer patients by routine tests.
  
  
  METHODS
  A total of 2328 patients with different types of cancer were classified as the positive group (n = 1419, including 53 patients with thrombosis) and the negative group (n = 909) based on D-dimer (DD) value. Of the 2328 cases, 354 were admitted for chemotherapy. Hemostasis test and complete blood count (CBC) were performed during treatment or following-up.
  
  
  RESULTS
  This study showed that the hypercoagulable state was affected not only by clinical staging (P < 0.0001) but also by metastasis site (P < 0.0001 for bone vs. lung). Compared to negative DD group, the higher fibrinogen level, the extended activated partial thromboplastin time, and prothrombin time interacted markedly with disease clinical stage (P < 0.05) in the positive group. Between positive DD groups with and without thrombus, the significantly statistic difference in white blood cell (WBC) and DD (P < 0.05) rather than in red blood cell (RBC) and platelet count was observed. However, the higher DD level was not correlated with WBC, RBC, and platelet count in the positive DD group. Furthermore, the hypercoagulable plasma profile in cancer patients was moderated 2-3 weeks after chemotherapy (P < 0.05 for first six cycles).
  
  
  CONCLUSIONS
  The routine hemostatic parameters and CBC are valuable to assessment for thrombosis and chemotherapy even for disease prognosis.
authors.affiliation: Department of Oncology, Changzhou Second People's Hospital, The Affiliated Hospital of Nanjing Medical University, Changzhou, Jiangsu 213164, China.
authors.forename: Ying-Wei
authors.initials: YW
authors.lastname: Zhu
authors.affiliation: Oncology Institute, Changzhou Second People's Hospital, The Affiliated Hospital of Nanjing Medical University, Changzhou, Jiangsu 213164, China.
authors.forename: Tong-Bao
authors.initials: TB
authors.lastname: Feng
authors.affiliation: Neurologic Disease Research Laboratory, Changzhou Second People's Hospital, The Affiliated Hospital of Nanjing Medical University, Changzhou, Jiangsu 213164, China.
authors.forename: Xian-Ju
authors.initials: XJ
authors.lastname: Zhou
authors.affiliation: Department of Oncology, Changzhou Second People's Hospital, The Affiliated Hospital of Nanjing Medical University, Changzhou, Jiangsu 213164, China.
authors.forename: Xue-Li
authors.initials: XL
authors.lastname: Hu
authors.affiliation: Department of Oncology, Changzhou Second People's Hospital, The Affiliated Hospital of Nanjing Medical University, Changzhou, Jiangsu 213164, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Ding
authors.affiliation: Department of Oncology, Changzhou Second People's Hospital, The Affiliated Hospital of Nanjing Medical University, Changzhou, Jiangsu 213164, China.
authors.forename: Wen-Yu
authors.initials: WY
authors.lastname: Zhu
authors.affiliation: Department of Oncology, Changzhou Second People's Hospital, The Affiliated Hospital of Nanjing Medical University, Changzhou, Jiangsu 213164, China.
authors.forename: Dan-Ping
authors.initials: DP
authors.lastname: Qian
authors.affiliation: Department of Hematology, Changzhou Second People's Hospital, The Affiliated Hospital of Nanjing Medical University, Changzhou, Jiangsu 213164, China.
authors.forename: Yi-Wu
authors.initials: YW
authors.lastname: Sun
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001778:Blood Coagulation Disorders / Q000175:diagnosis*; D005260:Female; D006487:Hemostasis / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy* / Q000503:physiopathology / Q000628:therapy*; D012189:Retrospective Studies; D013927:Thrombosis / Q000503:physiopathology; D055815:Young Adult