title: THE INTRINSIC VALUE OF HFO FEATURES AS A BIOMARKER OF EPILEPTIC ACTIVITY.
abstract: High frequency oscillations (HFOs) are a promising biomarker of epileptic brain tissue and activity. HFOs additionally serve as a prototypical example of challenges in the analysis of discrete events in high-temporal resolution, intracranial EEG data. Two primary challenges are 1) dimensionality reduction, and 2) assessing feasibility of classification. Dimensionality reduction assumes that the data lie on a manifold with dimension less than that of the features space. However, previous HFO analysis have assumed a linear manifold, global across time, space (i.e. recording electrode/channel), and individual patients. Instead, we assess both a) whether linear methods are appropriate and b) the consistency of the manifold across time, space, and patients. We also estimate bounds on the Bayes classification error to quantify the distinction between two classes of HFOs (those occurring during seizures and those occurring due to other processes). This analysis provides the foundation for future clinical use of HFO features and guides the analysis for other discrete events, such as individual action potentials or multi-unit activity.
authors.affiliation: University of Michigan, Department of Neurology, Ann Arbor, Michigan, U.S.A.
authors.forename: Stephen V
authors.initials: SV
authors.lastname: Gliske
authors.affiliation: University of Michigan, Department of Neurology, Ann Arbor, Michigan, U.S.A.
authors.forename: William C
authors.initials: WC
authors.lastname: Stacey
authors.affiliation: University of Michigan, Electrical Engineering and Computer Science, Ann Arbor, Michigan, U.S.A.
authors.forename: Kevin R
authors.initials: KR
authors.lastname: Moon
authors.affiliation: University of Michigan, Electrical Engineering and Computer Science, Ann Arbor, Michigan, U.S.A.
authors.forename: Alfred O
authors.initials: AO
authors.lastname: Hero
keywords: classification error; dimensionality reduction; divergence; high-frequency oscillation; intrinsic dimension