title: Role of functional imaging in treatment plan optimization of stereotactic body radiation therapy for liver cancer.
abstract: We report the first known instance of the clinical use of 99mTc-mebrofenin hepatobiliary scintigraphy (HBS) for the optimization of radiotherapy treatment planning and for the follow-up of acute toxicity in a patient undergoing stereotactic body radiation therapy for hepatocellular carcinoma. In our experience, HBS allowed the identification and the sparing of more functioning liver areas, thus potentially reducing the risk of radiation-induced liver toxicity.
authors.affiliation: Radiation Oncology Department, Centre Hospitalier Universitaire Vaudois - CHUV, Lausanne - Switzerland.
authors.forename: Berardino
authors.initials: B
authors.lastname: De Bari
authors.affiliation: Radiation Oncology Department, Centre Hospitalier Universitaire Vaudois - CHUV, Lausanne - Switzerland.
authors.forename: Raphael
authors.initials: R
authors.lastname: Jumeau
authors.affiliation: Radiation Oncology Department, Centre Hospitalier Universitaire Vaudois - CHUV, Lausanne - Switzerland.|Current address: Radiotherapy Unit, Department of Translational Medicine, University of Piemonte Orientale, Novara - Italy.
authors.forename: Letizia
authors.initials: L
authors.lastname: Deantonio
authors.affiliation: Nuclear Medicine and Molecular Medicine Department, Centre Hospitalier Universitaire Vaudois - CHUV, Lausanne - Switzerland.
authors.forename: Salim
authors.initials: S
authors.lastname: Adib
authors.affiliation: Radiation Oncology Department, Centre Hospitalier Universitaire Vaudois - CHUV, Lausanne - Switzerland.
authors.forename: Sarah
authors.initials: S
authors.lastname: Godin
authors.affiliation: Medical Physics, Centre Hospitalier Universitaire Vaudois - CHUV, Lausanne - Switzerland.
authors.forename: Michele
authors.initials: M
authors.lastname: Zeverino
authors.affiliation: Medical Physics, Centre Hospitalier Universitaire Vaudois - CHUV, Lausanne - Switzerland.
authors.forename: Raphael
authors.initials: R
authors.lastname: Moeckli
authors.affiliation: Radiation Oncology Department, Centre Hospitalier Universitaire Vaudois - CHUV, Lausanne - Switzerland.
authors.forename: Jean
authors.initials: J
authors.lastname: Bourhis
authors.affiliation: Nuclear Medicine and Molecular Medicine Department, Centre Hospitalier Universitaire Vaudois - CHUV, Lausanne - Switzerland.
authors.forename: John O
authors.initials: JO
authors.lastname: Prior
authors.affiliation: Radiation Oncology Department, Centre Hospitalier Universitaire Vaudois - CHUV, Lausanne - Switzerland.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Ozsahin
mesh_terms: D000369:Aged, 80 and over; D000814:Aniline Compounds; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging* / Q000532:radiotherapy*; D005998:Glycine; D006801:Humans; D007098:Imino Acids; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D016634:Radiosurgery / Q000009:adverse effects / Q000379:methods; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000814:Aniline Compounds; D007098:Imino Acids; D015609:Organotechnetium Compounds; C034837:technetium Tc 99m mebrofenin; D005998:Glycine