title: [Study on polymorphisms of genes with susceptibility to drug induced liver injury in a cohort receiving anti-tuberculosis treatment].
abstract: OBJECTIVE
  To investigate the association between the polymorphisms of genes involving in drug metabolism and transport as well as immunological reaction and the risk of anti-tuberculosis drug-induced liver injury(ATLI)in Chinese.
  
  
  METHODS
  This 1∶4 matched case-control study was conducted by using the data from a cohort study of Anti-tuberculosis Drugs Induced Adverse Reactions in National Tuberculosis Prevention and Control Progtam of China. Genes involving in three phase of drug metabolism and transport as well as related immunological reaction were chosen and single nucleotide polymorphisms(SNPs)were genotyped by TaqMan allele discrimination technology. Lasso regression and multivariate conditional logistic regression analysis were used to select susceptible genes.
  
  
  RESULTS
  A total of 33 genes with 75 SNPs were tested. The combined results of Lasso and regression logistic regression analysis showed that genetic polymorphism of SLCO1B1 rs4149014, HSPA1L rs2227956, STAT3 rs1053023 and IL-6 rs2066992 were significantly associated with the risk of ATLI(P<0.05).
  
  
  CONCLUSIONS
  SLCO1B1, HSPA1L, STAT3 and IL-6 might be the susceptibility genes of drug induced liver injury in patients receiving anti-tuberculosis treatment.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
authors.forename: R
authors.initials: R
authors.lastname: Chen
authors.affiliation: Department of Paediatrics, The University of Melbourne, and Murdoch Children Research Institute, Melbourne 3010, Australia.
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
authors.forename: S W
authors.initials: SW
authors.lastname: Tang
authors.affiliation: Clinical Research Division, Peking University Institute of Mental Health, Beijing 100191, China.
authors.forename: X Z
authors.initials: XZ
authors.lastname: Lyu
authors.affiliation: Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton L8S4K1, Canada.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Beijing Friendship Hospital, Capital Medical University, and National Clinical Research Center of Digestive Diseases, Beijing 100050, China.
authors.forename: S S
authors.initials: SS
authors.lastname: Wu
authors.affiliation: Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
authors.forename: Y Y
authors.initials: YY
authors.lastname: Xia
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
authors.forename: S Y
authors.initials: SY
authors.lastname: Zhan
mesh_terms: D000995:Antitubercular Agents / Q000009:adverse effects / Q000627:therapeutic use* / Q000633:toxicity*; D044466:Asian People; D016022:Case-Control Studies; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents; D015850:Interleukin-6