title: [Effect of miR-101 on biological characteristics of colorectal cancer cell line SW620].
abstract: OBJECTIVE
  To investigate the effect of miR-101 on biological behaviors of colorectal cancer cell line SW620.
  
  
  METHODS
  CCK-8 method, colony formation assay, cell cycle analysis and apoptosis analysis were applied to assess the effects of miR-101 on cell proliferation, invasion and apoptosis of SW620 cells.
  
  
  RESULTS
  Over-expression of miR-101 in SW620 cells significantly suppressed the cell proliferation and attenuated the colony-forming ability of the cells. Flow cytometry showed that over-expression of miR-101 in SW620 cells caused obvious cell cycle arrest in G2/M and 1/ phases, and significantly increased the cell apoptosis rate.
  
  
  CONCLUSIONS
  Over-expression of miR-101 can inhibit the proliferation, cause cell cycle arrest and promote apoptosis of colorectal cancer SW620 cells.
authors.affiliation: Department of Pathology, North Sichuan Medical College, Sichuan Province, Nanchong 637000, China.E-mail: liuyanruoshui@163.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Yan-Xia
authors.initials: YX
authors.lastname: Lu
authors.forename: Min
authors.initials: M
authors.lastname: Zhou
authors.forename: Lin
authors.initials: L
authors.lastname: Zheng
authors.forename: Xue-Nong
authors.initials: XN
authors.lastname: Li
mesh_terms: D017209:Apoptosis; D059447:Cell Cycle Checkpoints; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D015179:Colorectal Neoplasms / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009361:Neoplasm Invasiveness
chemical_list: C534072:MIRN101 microRNA, human; D035683:MicroRNAs