title: Biomineralization of Versatile CuS/Gd2 O3 Hybrid Nanoparticles for MR Imaging and Antitumor Photothermal Chemotherapy.
abstract: The versatile application of nanoparticles in integrating imaging and therapy has aroused extensive research interest in precision medicine. Of the various nanoparticles that have been studied, CuS has shown great potential in the construction of multifunctional agents, owing to its excellent photothermal heating properties. Herein, we report a facile one-pot biomineralization approach for the preparation of versatile bovine-serum-albumin-conjugated CuS/Gd2 O3 hybrid nanoparticles (BSA-CuS/Gd2 O3 HNPs), which simultaneously possessed strong longitudinal relaxivity, an outstanding photothermal effect, high drug-loading capacity, and pH/temperature-responsive drug release. The versatile nanoparticles were used for magnetic resonance imaging (MRI) and antitumor photothermal chemotherapy, both in vitro and in vivo. In vivo MRI showed that the BSA-CuS/Gd2 O3 HNPs had a long circulation time and effective passive tumor-uptake ability. More importantly, combined in vitro and in vivo therapy demonstrated that drug-loaded BSA-CuS/Gd2 O3 HNPs offered outstanding synergistic therapeutic efficacy for tumor inhibition.
authors.affiliation: College of Chemistry, Research Center for Analytical Sciences, State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Molecular Recognition and Biosensing and, Collaborative Innovation Center of Chemical Science and Engineering, Nankai University, Tianjin, 300071, P. R. China.
authors.forename: Huai-Xin
authors.initials: HX
authors.lastname: Zhao
authors.affiliation: School of Medical Imaging, Tianjin Medical University, Tianjin, 300203, P. R. China.
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.affiliation: School of Medical Imaging, Tianjin Medical University, Tianjin, 300203, P. R. China.
authors.forename: Quan
authors.initials: Q
authors.lastname: Zou
authors.affiliation: School of Medical Imaging, Tianjin Medical University, Tianjin, 300203, P. R. China.
authors.forename: Shao-Kai
authors.initials: SK
authors.lastname: Sun
authors.affiliation: School of Medical Imaging, Tianjin Medical University, Tianjin, 300203, P. R. China.|Department of Radiology, Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, 300052, P. R. China.
authors.forename: Chunshui
authors.initials: C
authors.lastname: Yu
authors.affiliation: School of Medical Imaging, Tianjin Medical University, Tianjin, 300203, P. R. China.
authors.forename: Xuejun
authors.initials: X
authors.lastname: Zhang
authors.affiliation: School of Medical Imaging, Tianjin Medical University, Tianjin, 300203, P. R. China. fuyanyan365@163.com.
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Fu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003300:Copper / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D005260:Female; D005682:Gadolinium / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D008807:Mice, Inbred BALB C; D053758:Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D010789:Phototherapy / Q000379:methods*; D012710:Serum Albumin, Bovine; D013696:Temperature
chemical_list: D000970:Antineoplastic Agents; D012710:Serum Albumin, Bovine; D003300:Copper; D005682:Gadolinium; C017846:cupric sulfide
keywords: antitumor agents; biomineralization; hybrid materials; imaging agents; nanoparticles