title: Plasma thiols and thiol-disulfide homeostasis in patients with isolated coronary artery ectasia.
abstract: Thiol/disulfide homeostasis has an important role in the antioxidant defense system. Oxidative stress may contribute to the pathogenesis of coronary artery ectasia. The aim of this study was to evaluate plasma thiol levels and thiol/disulfide homeostasis in patients with isolated coronary artery ectasia.
  
  
  
  Forty-one patients with isolated coronary artery ectasia and 72 patients with normal coronary arteries were included in the study. Markis classification and number of ectatic coronary arteries were recorded. Plasma total thiol levels, native thiol levels and disulfide levels were measured. Thiol/disulfide homeostasis was appraised by calculating thiol/disulfide ratio.
  
  
  
  Plasma native thiol levels were significantly lower (336.9 (252.9-374.1) vs. 353.1 (327.0-380.0), p = 0.041) and disulfide levels were significantly higher (18.9 ± 6.3 vs. 16.6 ± 3.4, p = 0.014) in patients with coronary artery ectasia than control patients. Both native thiol/disulfide and total thiol/disulfide ratio was significantly lower in the coronary artery ectasia group (p < 0.001). Multivariate logistic regression analysis revealed that native thiol levels, disulfide levels and native thiol/disulfide ratio were independently associated with the presence of coronary artery ectasia. Thiol/disulfide ratio was not different according to number of ectatic coronary arteries and there was no association between thiol/disulfide ratio and Markis classification.
  
  
  
  Plasma thiol/disulfide homeostasis is altered in patients with coronary artery ectasia.
authors.affiliation: Numune Education and Research Hospital Cardiology Department, Ankara, Turkey. Electronic address: e.kiziltunc@gmail.com.
authors.forename: Emrullah
authors.initials: E
authors.lastname: Kızıltunç
authors.affiliation: Numune Education and Research Hospital Cardiology Department, Ankara, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Gök
authors.affiliation: Numune Education and Research Hospital Cardiology Department, Ankara, Turkey.
authors.forename: Harun
authors.initials: H
authors.lastname: Kundi
authors.affiliation: Numune Education and Research Hospital Cardiology Department, Ankara, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Çetin
authors.affiliation: Numune Education and Research Hospital Cardiology Department, Ankara, Turkey.
authors.forename: Canan
authors.initials: C
authors.lastname: Topçuoğlu
authors.affiliation: Numune Education and Research Hospital Cardiology Department, Ankara, Turkey.
authors.forename: Birsen
authors.initials: B
authors.lastname: Gülkan
authors.affiliation: Numune Education and Research Hospital Cardiology Department, Ankara, Turkey.
authors.forename: Hülya
authors.initials: H
authors.lastname: Çiçekçioğlu
authors.affiliation: Numune Education and Research Hospital Cardiology Department, Ankara, Turkey.
authors.forename: Ender
authors.initials: E
authors.lastname: Örnek
mesh_terms: D000368:Aged; D003331:Coronary Vessels / Q000473:pathology*; D003430:Cross-Sectional Studies; D004108:Dilatation, Pathologic / Q000097:blood* / Q000473:pathology*; D004220:Disulfides / Q000097:blood*; D005260:Female; D006706:Homeostasis; D006801:Humans; D006973:Hypertension; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D018384:Oxidative Stress; D013438:Sulfhydryl Compounds / Q000097:blood*
chemical_list: D004220:Disulfides; D013438:Sulfhydryl Compounds
keywords: Coronary artery ectasia; Oxidative stress; Thiol