title: Chondroitin sulfate derived theranostic nanoparticles for targeted drug delivery.
abstract: Glycosaminoglycan derived nanoparticles are a promising delivery system owing to their unique tumour targeting ability. Exploiting fluorescein for inducing amphiphilicity in these biopolymers provides inherent imaging and drug stabilization capabilities by π-π stacking interactions with aromatic antineoplastic agents. This offers a versatile and highly customizable nanocarrier with narrow size distribution and high drug loading efficiency (80%) with sustained drug release.
authors.affiliation: Department of Chemistry, Ångström Laboratory, Uppsala University, SE-75121, Sweden. oommen.op@kemi.uu.se.
authors.forename: Oommen P
authors.initials: OP
authors.lastname: Varghese
authors.affiliation: Department of Bioscience and Nutrition, Karolinska Institute, Huddinge, Stockholm, SE-14183, Sweden.
authors.forename: Jianping
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Chemistry, Ångström Laboratory, Uppsala University, SE-75121, Sweden. oommen.op@kemi.uu.se.
authors.forename: Karthi
authors.initials: K
authors.lastname: Sundaram
authors.affiliation: Department of Chemistry, Ångström Laboratory, Uppsala University, SE-75121, Sweden. oommen.op@kemi.uu.se.
authors.forename: Jöns
authors.initials: J
authors.lastname: Hilborn
authors.affiliation: Department of Chemistry, Ångström Laboratory, Uppsala University, SE-75121, Sweden. oommen.op@kemi.uu.se and BioMediTech - Institute of Biosciences and Medical Technology, Bioengineering and Nanomedicine Group, Tampere University of Technology, 33520, Tampere, Finland.
authors.forename: Oommen P
authors.initials: OP
authors.lastname: Oommen
mesh_terms: D002809:Chondroitin Sulfates / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*; D000068936:Theranostic Nanomedicine / Q000379:methods*
chemical_list: D004337:Drug Carriers; D002809:Chondroitin Sulfates