title: Extended surface for membrane association in Zika virus NS1 structure.
abstract: The Zika virus, which has been implicated in an increase in neonatal microcephaly and Guillain-Barré syndrome, has spread rapidly through tropical regions of the world. The virulence protein NS1 functions in genome replication and host immune-system modulation. Here, we report the crystal structure of full-length Zika virus NS1, revealing an elongated hydrophobic surface for membrane association and a polar surface that varies substantially among flaviviruses.
authors.affiliation: Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA.
authors.forename: W Clay
authors.initials: WC
authors.lastname: Brown
authors.affiliation: Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA.
authors.forename: David L
authors.initials: DL
authors.lastname: Akey
authors.affiliation: Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA.
authors.forename: Jamie R
authors.initials: JR
authors.lastname: Konwerski
authors.affiliation: Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA.
authors.forename: Jeffrey T
authors.initials: JT
authors.lastname: Tarrasch
authors.affiliation: Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA.|Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, USA.
authors.forename: Georgios
authors.initials: G
authors.lastname: Skiniotis
authors.affiliation: Department of Biological Sciences, Purdue University, West Lafayette, Indiana, USA.|Purdue Institute for Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, Indiana, USA.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Kuhn
authors.affiliation: Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA.|Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, USA.
authors.forename: Janet L
authors.initials: JL
authors.lastname: Smith
mesh_terms: D000818:Animals; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D054730:Protein Interaction Domains and Motifs; D020836:Protein Structure, Quaternary; D061987:Sf9 Cells; D018411:Spodoptera; D013499:Surface Properties; D017361:Viral Nonstructural Proteins / Q000737:chemistry*; D053585:Virus Attachment; D000071244:Zika Virus / Q000648:ultrastructure
chemical_list: D017361:Viral Nonstructural Proteins