title: Epigenetic code and insect behavioural plasticity.
abstract: Although the nature of the genetic control of adaptive behaviours in insects is a major unresolved problem it is now understood that epigenetic mechanisms, bound by genetic constraints, are prime drivers of brain plasticity arising from both developmental and experience-dependent events. With the recent advancements in methylomics and emerging analyses of histones and non-protein-coding RNAs, insect epigenetics is well positioned to ask more direct questions and importantly, address them experimentally. To achieve rapid progress, insect epigenetics needs to focus on mechanistic explanations of epigenomic dynamics and move beyond low-depth genome-wide analyses to cell-type specific epigenomics. One topic of a high priority is the impact of sequence variants on generating differential methylation patterns and their contribution to behavioural plasticity.
authors.affiliation: The Australian National University, Canberra, ACT 2601, Australia. Electronic address: ryszard.maleszka@anu.edu.au.
authors.forename: Ryszard
authors.initials: R
authors.lastname: Maleszka
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D000066670:Cell Plasticity; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D057890:Epigenomics; D005815:Genetic Code; D007313:Insecta / Q000235:genetics*; D009473:Neuronal Plasticity / Q000235:genetics