title: Hot flushes and night sweats symptom profiles over a 17-year period in mid-aged women: The role of hysterectomy with ovarian conservation.
abstract: OBJECTIVE
  There is limited research on hot flushes and night sweats in women with a hysterectomy with ovarian conservation. We aimed to describe the patterns of these symptoms in a cohort of Australian women and to investigate the relationship between distinct symptom patterns and hysterectomy status.
  
  
  METHODS
  Repeated-measures latent class analysis (LCA) was used to identify hot flushes and night sweats symptom patterns across seven surveys (over 17 years) in the mid-cohort of the Australian Longitudinal Study on Women's Health. Multinomial logistic regression was used to assess the associations of the symptom patterns in women with a hysterectomy with ovarian conservation (n=1129) versus women without a hysterectomy (n=4977).
  
  
  RESULTS
  A higher proportion of women with a hysterectomy than of those without experienced a constant pattern of hot flushes (15% versus 30%) and night sweats (9% versus 19%). Women with a hysterectomy had higher odds of constant hot flushes versus minimal hot flushes (OR=1.97, 95% CI: 1.64, 2.35) and constant versus minimal night sweats (OR=2.09, 95% CI: 1.70, 2.55). Smoking, a 'lower level of education to non-professional occupation' pathway and body mass index (BMI) patterns of 'always obese' and 'increasingly obese' were also associated with a higher risk of constant symptoms.
  
  
  CONCLUSIONS
  Women who have a hysterectomy (with ovarian conservation) have a higher risk of hot flushes and night sweats that persist over an extended period.
authors.affiliation: The University of Queensland, Centre for Longitudinal and Life Course Research, School of Public Health, Public Health Building, Herston Road, Herston, QLD 4006, Australia. Electronic address: l.wilson8@uq.edu.au.
authors.forename: Louise F
authors.initials: LF
authors.lastname: Wilson
authors.affiliation: The University of Queensland, Centre for Longitudinal and Life Course Research, School of Public Health, Public Health Building, Herston Road, Herston, QLD 4006, Australia.
authors.forename: Nirmala
authors.initials: N
authors.lastname: Pandeya
authors.affiliation: Research Centre for Generational Health and Ageing, Faculty of Health and Medicine, The University of Newcastle, Australia.
authors.forename: Julie
authors.initials: J
authors.lastname: Byles
authors.affiliation: The University of Queensland, Centre for Longitudinal and Life Course Research, School of Public Health, Public Health Building, Herston Road, Herston, QLD 4006, Australia.
authors.forename: Gita D
authors.initials: GD
authors.lastname: Mishra
mesh_terms: D000368:Aged; D002940:Circadian Rhythm; D015331:Cohort Studies; D005260:Female; D019584:Hot Flashes / Q000453:epidemiology / Q000503:physiopathology*; D006801:Humans; D007044:Hysterectomy; D008137:Longitudinal Studies; D008593:Menopause / Q000502:physiology*; D008875:Middle Aged; D010053:Ovary / Q000502:physiology; D011793:Queensland / Q000453:epidemiology; D011795:Surveys and Questionnaires; D013546:Sweating; D016387:Women's Health
keywords: Body mass index; Hot flashes; Hysterectomy; Menopause; Night sweats; Smoking