title: Differences in Cognitive Function of Rats with Traumatic Brain Injuries Following Hyperbaric Oxygen Therapy.
abstract: BACKGROUND Hyperbaric oxygen (HBO) is a historical therapeutic option in the treatment of various types of brain damage. At present, clinical treatment of hypoxic-ischemic injury is giving priority to cognitive training. The effects of HBO on cognitive dysfunction were observed in a controlled cortical impact (CCI) rat model. MATERIAL AND METHODS Seventy male SD rats were randomly divided into control (n=10) and intervention (n=60) groups. All rats underwent baseline water maze testing 1 day before modeling, and were retested 8 weeks after modeling. The percentage of residence time during escape latency in the target quadrant and the total time were recorded. Data were analyzed by SPSS 16.0 software. P<0.05 was considered statistically significant. RESULTS After 8 weeks, no statistical difference (P>0.05) existed in spatial learning ability in the 3-day and 5-day groups when compared with baseline. The other groups were statistically different by auto-comparison (P<0.05). No statistical difference (P>0.05) in spatial memory existed in the 5-day and 1-week groups when compared with baseline, while a significant difference was noted in the other groups by self-comparison (P<0.05). No statistical difference (P>0.05) was noted in the level of expression of growth-associated protein-43 (GAP-43) and synaptophysin (Syn) in the 1-day group compared with the control group. The remaining groups and the control group were statistically different (P<0.05), while the level of expression of GAP-43 and Syn in the 5-day, 1-week, and 2-week groups was significantly different compared with that in the control group (P<0.01). CONCLUSIONS If HBO therapy was provided 5-7 days after craniocerebral trauma, there was apparent improvement in cognitive function and neuroplasticity.
authors.affiliation: China Rehabilitation Research Center, Beijing Key Laboratory of Neural Injury and Rehabilitation, Capital Medical University, Beijing, China (mainland).
authors.forename: Xiaonian
authors.initials: X
authors.lastname: Zhang
authors.affiliation: China Rehabilitation Research Center, Beijing Key Laboratory of Neural Injury and Rehabilitation, Capital Medical University, Beijing, China (mainland).
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Wang
authors.affiliation: China Rehabilitation Research Center, Beijing Key Laboratory of Neural Injury and Rehabilitation, Capital Medical University, Beijing, China (mainland).
authors.forename: Xinting
authors.initials: X
authors.lastname: Sun
authors.affiliation: China Rehabilitation Research Center, Beijing Key Laboratory of Neural Injury and Rehabilitation, Capital Medical University, Beijing, China (mainland).
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Sun
authors.affiliation: China Rehabilitation Research Center, Beijing Key Laboratory of Neural Injury and Rehabilitation, Capital Medical University, Beijing, China (mainland).
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: China Rehabilitation Research Center, Beijing Key Laboratory of Neural Injury and Rehabilitation, Capital Medical University, Beijing, China (mainland).
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000070642:Brain Injuries, Traumatic / Q000209:etiology* / Q000523:psychology*; D003071:Cognition / Q000502:physiology*; D006931:Hyperbaric Oxygenation / Q000009:adverse effects* / Q000379:methods*; D020925:Hypoxia-Ischemia, Brain / Q000628:therapy; D008297:Male; D018782:Maze Learning; D023421:Models, Animal; D009473:Neuronal Plasticity / Q000502:physiology; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley