title: Predictors of 6-month health utility outcomes in survivors of acute respiratory distress syndrome.
abstract: With improving short-term mortality in acute respiratory distress syndrome (ARDS), understanding and improving quality of life (QOL) outcomes in ARDS survivors is a clinical and research priority. We sought to identify variables associated with QOL, as measured by the EQ-5D health utility score, after ARDS using contemporary data science methods.
  
  
  
  Analysis of prospectively acquired baseline variables and 6-month EQ-5D health utility scores for adults with ARDS enrolled in the ARDS Network Long-Term Outcomes Study (ALTOS). Penalised regression identified predictors of health utility, with results validated using 10-fold cross-validation.
  
  
  
  Among 616 ARDS survivors, several predictors were associated with 6-month EQ-5D utility scores, including two lifestyle factors. Specifically, older age, female sex, Hispanic/Latino ethnicity, current smoking and higher body mass index were associated with lower EQ-5D utilities, while living at home without assistance at baseline and AIDS were associated with higher EQ-5D utilities in ARDS survivors. No acute illness variables were associated with EQ-5D utility.
  
  
  
  Acute illness variables do not appear to be associated with postdischarge QOL among ARDS survivors. Functional independence and lifestyle factors, such as obesity and tobacco smoking, were associated with worse QOL. Future analyses of postdischarge health utility among ARDS survivors should incorporate measures of demographics and functional independence at baseline.
  
  
  
  NCT00719446 (ALTOS), NCT00434993 (ALTA), NCT00609180 (EDEN/OMEGA), and NCT00883948 (EDEN); Post-results.
authors.affiliation: Center for Humanizing Critical Care, Intermountain Healthcare, Murray, Utah, USA.|Department of Medicine, Pulmonary and Critical Care Division, Intermountain Medical Center, Murray, Utah, USA.|Pulmonary and Critical Care, University of Utah School of Medicine, Salt Lake City, Utah, USA.
authors.forename: Samuel M
authors.initials: SM
authors.lastname: Brown
authors.affiliation: Center for Humanizing Critical Care, Intermountain Healthcare, Murray, Utah, USA.|Department of Medicine, Pulmonary and Critical Care Division, Intermountain Medical Center, Murray, Utah, USA.
authors.forename: Emily
authors.initials: E
authors.lastname: Wilson
authors.affiliation: Division of Epidemiology, Study Design and Biostatistics Center, University of Utah School of Medicine, Salt Lake City, Utah, USA.
authors.forename: Angela P
authors.initials: AP
authors.lastname: Presson
authors.affiliation: Division of Epidemiology, Study Design and Biostatistics Center, University of Utah School of Medicine, Salt Lake City, Utah, USA.
authors.forename: Chong
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Outcomes After Critical Illness and Surgery Group, Johns Hopkins University, Baltimore, Maryland, USA.|Division of Pulmonary and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
authors.forename: Victor D
authors.initials: VD
authors.lastname: Dinglas
authors.affiliation: Division of Epidemiology, Study Design and Biostatistics Center, University of Utah School of Medicine, Salt Lake City, Utah, USA.
authors.forename: Tom
authors.initials: T
authors.lastname: Greene
authors.affiliation: Center for Humanizing Critical Care, Intermountain Healthcare, Murray, Utah, USA.|Department of Medicine, Pulmonary and Critical Care Division, Intermountain Medical Center, Murray, Utah, USA.|Department of Psychology, Neuroscience Center, Brigham Young University, Provo, Utah, USA.
authors.forename: Ramona O
authors.initials: RO
authors.lastname: Hopkins
authors.affiliation: Outcomes After Critical Illness and Surgery Group, Johns Hopkins University, Baltimore, Maryland, USA.|Division of Pulmonary and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.|Department of Physical Medicine and Rehabilitation, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
authors.forename: Dale M
authors.initials: DM
authors.lastname: Needham
mesh_terms: D018806:APACHE; D000208:Acute Disease; D000328:Adult; D000367:Age Factors; D015992:Body Mass Index; D005260:Female; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011788:Quality of Life; D012128:Respiratory Distress Syndrome / Q000208:ethnology / Q000628:therapy*; D012737:Sex Factors; D012907:Smoking; D017741:Survivors
keywords: ARDS