title: Photoredox-Catalyzed Ketyl-Olefin Coupling for the Synthesis of Substituted Chromanols.
abstract: A visible light photoredox-catalyzed aldehyde olefin cyclization is reported. The method represents a formal hydroacylation of alkenes and alkynes and provides chromanol derivatives in good yields. The protocol takes advantage of the double role played by trialkylamines (NR3) which act as (i) electron donors for reducing the catalyst and (ii) proton donors to activate the substrate via a proton-coupled electron transfer.
authors.affiliation: RWTH Aachen University , Institute of Organic Chemistry, Landoltweg 1, 52074, Aachen, Germany.|King Abdullah University of Science and Technology (KAUST) , KAUST Catalysis Center (KCC), Thuwal, 23955-6900, Saudi Arabia.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Fava
authors.affiliation: RWTH Aachen University , Institute of Organic Chemistry, Landoltweg 1, 52074, Aachen, Germany.
authors.forename: Masaki
authors.initials: M
authors.lastname: Nakajima
authors.affiliation: RWTH Aachen University , Institute of Organic Chemistry, Landoltweg 1, 52074, Aachen, Germany.
authors.forename: Anh L P
authors.initials: AL
authors.lastname: Nguyen
authors.affiliation: RWTH Aachen University , Institute of Organic Chemistry, Landoltweg 1, 52074, Aachen, Germany.|King Abdullah University of Science and Technology (KAUST) , KAUST Catalysis Center (KCC), Thuwal, 23955-6900, Saudi Arabia.
authors.forename: Magnus
authors.initials: M
authors.lastname: Rueping