title: Association of TLR polymorphisms with bronchopulmonary dysplasia.
abstract: Bronchopulmonary dysplasia (BPD) remains a leading cause of morbidity and mortality during infancy. Evidence suggests that the Toll-like receptor (TLR) signaling pathway plays an integral role in lung inflammation and injury. This study aimed to detect single nucleotide polymorphisms (SNPs) in TLR pathway genes [TLR5 and Toll-interleukin 1 receptor domain-containing adaptor protein (TIRAP)] among preterm neonates and to determine their association with the development and severity of bronchopulmonary dysplasia.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt. Electronic address: malash5@yahoo.com.
authors.forename: Amr Hosny
authors.initials: AH
authors.lastname: Malash
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt. Electronic address: draliaaadel@yahoo.com.
authors.forename: Aliaa Adel
authors.initials: AA
authors.lastname: Ali
authors.affiliation: Clinical Pathology, Faculty of Medicine, Cairo University, Egypt. Electronic address: rania_sami1976@yahoo.com.
authors.forename: Rania Mohamed
authors.initials: RM
authors.lastname: Samy
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt. Electronic address: radwa.shamma@hotmail.com.
authors.forename: Radwa Ahmed
authors.initials: RA
authors.lastname: Shamma
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017472:Receptors, Interleukin-1 / Q000235:genetics*; D051198:Toll-Like Receptor 5 / Q000235:genetics*
chemical_list: D008562:Membrane Glycoproteins; D017472:Receptors, Interleukin-1; C434984:TIRAP protein, human; C495346:TLR5 protein, human; D051198:Toll-Like Receptor 5
keywords: Bronchopulmonary dysplasia; Neonatal mortality; Oxygen therapy; Preterm neonates; Sepsis; Toll-like receptors