title: Drosophila hematopoiesis under normal conditions and in response to immune stress.
abstract: The emergence of hematopoietic progenitors and their differentiation into various highly specialized blood cell types constitute a finely tuned process. Unveiling the genetic cascades that control blood cell progenitor fate and understanding how they are modulated in response to environmental changes are two major challenges in the field of hematopoiesis. In the last 20 years, many studies have established important functional analogies between blood cell development in vertebrates and in the fruit fly, Drosophila melanogaster. Thereby, Drosophila has emerged as a powerful genetic model for studying mechanisms that control hematopoiesis during normal development or in pathological situations. Moreover, recent advances in Drosophila have highlighted how intricate cell communication networks and microenvironmental cues regulate blood cell homeostasis. They have also revealed the striking plasticity of Drosophila mature blood cells and the presence of different sites of hematopoiesis in the larva. This review provides an overview of Drosophila hematopoiesis during development and summarizes our current knowledge on the molecular processes controlling larval hematopoiesis, both under normal conditions and in response to an immune challenge, such as wasp parasitism.
authors.affiliation: Centre de Biologie du Développement, UMR 5547 CNRS/Université Toulouse III and Centre de Biologie Intégrative, Toulouse Cedex 9, France.
authors.forename: Manon
authors.initials: M
authors.lastname: Letourneau
authors.affiliation: Centre de Biologie du Développement, UMR 5547 CNRS/Université Toulouse III and Centre de Biologie Intégrative, Toulouse Cedex 9, France.
authors.forename: Francois
authors.initials: F
authors.lastname: Lapraz
authors.affiliation: Centre de Biologie du Développement, UMR 5547 CNRS/Université Toulouse III and Centre de Biologie Intégrative, Toulouse Cedex 9, France.|Department of Biomedical Sciences, NU Centre for Science Education & Research, Nitte University, Mangalore-18, India.
authors.forename: Anurag
authors.initials: A
authors.lastname: Sharma
authors.affiliation: Centre de Biologie du Développement, UMR 5547 CNRS/Université Toulouse III and Centre de Biologie Intégrative, Toulouse Cedex 9, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Vanzo
authors.affiliation: Centre de Biologie du Développement, UMR 5547 CNRS/Université Toulouse III and Centre de Biologie Intégrative, Toulouse Cedex 9, France.
authors.forename: Lucas
authors.initials: L
authors.lastname: Waltzer
authors.affiliation: Centre de Biologie du Développement, UMR 5547 CNRS/Université Toulouse III and Centre de Biologie Intégrative, Toulouse Cedex 9, France.
authors.forename: Michèle
authors.initials: M
authors.lastname: Crozatier
mesh_terms: D000818:Animals; D001773:Blood Cells / Q000166:cytology*; D002450:Cell Communication; D002454:Cell Differentiation / Q000235:genetics; D060833:Cellular Microenvironment / Q000235:genetics; D004331:Drosophila melanogaster / Q000235:genetics* / Q000254:growth & development; D006410:Hematopoiesis / Q000235:genetics*; D006412:Hematopoietic Stem Cells; D006801:Humans; D007814:Larva / Q000235:genetics / Q000254:growth & development
keywords: Drosophila; hematopoiesis; immune response; parasitism