title: Systemic Mastocytosis as an Unconventional Cause of Variceal Bleeding: Think Outside the Box.
abstract: Systemic mastocytosis is a rare infiltrative disease involving the skin, bone marrow, digestive system, and liver. We report a case of a 59-year-old male who presented with a massive variceal bleed without any evidence of cirrhosis; however was later found to have severe perisinusoidal fibrosis with mast cells in portal tracts on liver biopsy and hypercellular mast cell infiltrated bone marrow. This rare case describes an out-of-the-ordinary reason of variceal bleeding with preserved liver function due to non-cirrhotic portal hypertension.
authors.affiliation: Department of Internal Medicine, Staten Island University Hospital, Northwell Health, Staten Island, NY, USA.
authors.forename: Moiz
authors.initials: M
authors.lastname: Ahmed
authors.affiliation: Department of Gastroenterology, Staten Island University Hospital, Northwell Health, Staten Island, NY, USA.
authors.forename: Mayurathan
authors.initials: M
authors.lastname: Kesavan
authors.affiliation: Department of Internal Medicine, Staten Island University Hospital, Northwell Health, Staten Island, NY, USA.
authors.forename: Basmah N
authors.initials: BN
authors.lastname: Jilani
authors.affiliation: Department of Internal Medicine, Nishtar Medical College, Multan, Pakistan.
authors.forename: Saba
authors.initials: S
authors.lastname: Ahmed
authors.affiliation: Department of Gastroenterology, Staten Island University Hospital, Northwell Health, Staten Island, NY, USA.
authors.forename: Liliane
authors.initials: L
authors.lastname: Deeb
keywords: infiltrative liver disease; non-cirrhotic portal hypertension; systemic mastocytosis; variceal bleeding