title: Emergence and Plasmid Analysis of Klebsiella pneumoniae KP01 Carrying blaGES-5 from Guangzhou, China.
abstract: Klebsiella pneumoniae strain KP01 carrying blaGES-5 was identified from a patient in Guangzhou, China. High-throughput sequencing assigned blaGES-5 to a 28.5-kb nonconjugative plasmid, pGES-GZ. A 13-kb plasmid backbone sequence on pGES-GZ was found to share high sequence identities with plasmids from Gram-negative nonfermenters. A novel class 1 integron carrying a gene cassette array of orf28-orf28-blaGES-5 was identified on pGES-GZ, within which orf28 encoded a hypothetical protein possibly correlated to fosfomycin resistance.
authors.affiliation: Laboratory Medicine Centre, Nanfang Hospital, Southern Medical University, Guangzhou, China Department of Laboratory Medicine, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
authors.forename: Ding-Qiang
authors.initials: DQ
authors.lastname: Chen
authors.affiliation: Department of Clinical Microbiology, KingMed College of Laboratory Medicine, Guangzhou Medical University, Guangzhou, China.
authors.forename: Ai-Wu
authors.initials: AW
authors.lastname: Wu
authors.affiliation: Department of Laboratory Medicine, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Laboratory Medicine, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
authors.forename: Dan-Hong
authors.initials: DH
authors.lastname: Su
authors.affiliation: Department of Laboratory Medicine, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
authors.forename: Yong-Ping
authors.initials: YP
authors.lastname: Lin
authors.affiliation: Laboratory Medicine Centre, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: Yan-Wei
authors.initials: YW
authors.lastname: Hu
authors.affiliation: Laboratory Medicine Centre, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zheng
authors.affiliation: Laboratory Medicine Centre, Nanfang Hospital, Southern Medical University, Guangzhou, China nfyywangqian@163.com.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
mesh_terms: D000368:Aged; D001426:Bacterial Proteins / Q000235:genetics*; D002681:China; D017714:Community-Acquired Infections / Q000382:microbiology; D024881:Drug Resistance, Bacterial / Q000235:genetics; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D032023:Integrons; D007710:Klebsiella Infections / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D008297:Male; D008826:Microbial Sensitivity Tests; D010957:Plasmids / Q000235:genetics; D018410:Pneumonia, Bacterial / Q000382:microbiology; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; D001618:beta-Lactamases; C000607155:beta-lactamase GES-5, Klebsiella pneumoniae