title: Indomethacin-guided cancer selective prodrug conjugate activated by histone deacetylase and tumour-associated protease.
abstract: An indomethacin-guided drug delivery conjugate (IGDDC) has been designed by utilizing cancer associated elevated HDAC and CTSL activities as consecutive demasking ventures for drug activation. IGDDC exhibited preferential uptake by COX-2 positive cells both in vitro and ex vivo highlighting indomethacin's role in designing new cancer-specific drug delivery frameworks.
authors.affiliation: Department of Chemistry, Korea University, Seoul 136-701, Korea. jongskim@korea.ac.kr.
authors.forename: Joo Hee
authors.initials: JH
authors.lastname: Jang
authors.affiliation: The School of East-West Medical Science, Kyung Hee University, Yongin, 446-701, Korea. kangch@khu.ac.kr.
authors.forename: Hoyeon
authors.initials: H
authors.lastname: Lee
authors.affiliation: Department of Chemistry, Korea University, Seoul 136-701, Korea. jongskim@korea.ac.kr.
authors.forename: Amit
authors.initials: A
authors.lastname: Sharma
authors.affiliation: The School of East-West Medical Science, Kyung Hee University, Yongin, 446-701, Korea. kangch@khu.ac.kr.
authors.forename: Sang Min
authors.initials: SM
authors.lastname: Lee
authors.affiliation: The School of East-West Medical Science, Kyung Hee University, Yongin, 446-701, Korea. kangch@khu.ac.kr.
authors.forename: Tae Hoon
authors.initials: TH
authors.lastname: Lee
authors.affiliation: The School of East-West Medical Science, Kyung Hee University, Yongin, 446-701, Korea. kangch@khu.ac.kr.
authors.forename: Chulhun
authors.initials: C
authors.lastname: Kang
authors.affiliation: Department of Chemistry, Korea University, Seoul 136-701, Korea. jongskim@korea.ac.kr.
authors.forename: Jong Seung
authors.initials: JS
authors.lastname: Kim
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D016503:Drug Delivery Systems / Q000379:methods*; D045325:HCT116 Cells; D006367:HeLa Cells; D056945:Hep G2 Cells; D006655:Histone Deacetylases / Q000008:administration & dosage; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000737:chemistry*; D010447:Peptide Hydrolases / Q000008:administration & dosage; D011355:Prodrugs / Q000008:administration & dosage / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D016861:Cyclooxygenase Inhibitors; D011355:Prodrugs; D010447:Peptide Hydrolases; D006655:Histone Deacetylases; D007213:Indomethacin