title: Dynamic contrast-enhanced MRI for the assessment of spinal tumor vascularity: correlation with angiography.
abstract: To determine if dynamic contrast-enhanced MRI (DCE-MRI) could correlate well with invasive angiography in the characterization of spinal tumor vascularity.
  
  
  
  Totally 40 patients with untreated spinal tumors underwent MRI before preoperative angiography and embolization. Tumors were assigned to hypervascular, moderate, or hypovascular groups based on angiographic appearance. Tumor vascularity was also evaluated with enhancement degree on standard MR and with DCE-MRI parameters via ROI analysis of enhanced tumor area. The Spearman correlation coefficient was calculated to determine the correlation between the degree of angiographic vascularity and enhancement on MRI and DCE-MRI parameters. ROC analysis was conducted to assess the appropriate cut-off value.
  
  
  
  There were 12 hypervascular, 12 moderate, and 16 hypovascular tumors, respectively. The Spearman correlation coefficient between DCE-MRI parameter and the degree of angiographic vascularity was 0.899 (RSlopemax), 0.847 (Slopemax), 0.697 (Emax), 0.694 (ERmax), and -0.587 (TTP), respectively, which showed excellent-to-moderate relationships. The RSlopemaxcut-off value of 1.325 provided the highest specificity of 100 % and sensitivity of 87.5 % in predicting hypovascular tumors and the value of 1.85 provided the highest sensitivity of 100 % and specificity of 96.4 % in characterizing hypervascular ones.
  
  
  
  DCE-MRI is an accurate technique for the assessment of spinal tumor vascularity, which may have a potential value in the decision-making of preoperative embolization.
authors.affiliation: Department of Interventional Radiology, Changzheng Hospital, The Second Military Medical University, Shanghai, 200003, China.
authors.forename: Xiao-Xi
authors.initials: XX
authors.lastname: Meng
authors.affiliation: Department of Radiology, 85 Hospital of PLA, Shanghai, 200003, China.
authors.forename: Yong-Qiu
authors.initials: YQ
authors.lastname: Zhang
authors.affiliation: Department of Interventional Radiology, Changzheng Hospital, The Second Military Medical University, Shanghai, 200003, China.
authors.forename: Hua-Qiang
authors.initials: HQ
authors.lastname: Liao
authors.affiliation: Department of Interventional Radiology, Changzheng Hospital, The Second Military Medical University, Shanghai, 200003, China.
authors.forename: Hong-Chao
authors.initials: HC
authors.lastname: Liu
authors.affiliation: Department of Interventional Radiology, Changzheng Hospital, The Second Military Medical University, Shanghai, 200003, China.
authors.forename: Hai-Lin
authors.initials: HL
authors.lastname: Jiang
authors.affiliation: Department of Interventional Radiology, Changzheng Hospital, The Second Military Medical University, Shanghai, 200003, China.
authors.forename: Shu-Jun
authors.initials: SJ
authors.lastname: Ke
authors.affiliation: Department of Interventional Radiology, Changzheng Hospital, The Second Military Medical University, Shanghai, 200003, China. drdongweihua@yeah.net.
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Dong
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000792:Angiography / Q000379:methods*; D003287:Contrast Media; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging; D012680:Sensitivity and Specificity; D013120:Spinal Cord Neoplasms / Q000000981:diagnostic imaging*; D055815:Young Adult
chemical_list: D003287:Contrast Media
keywords: Angiography; Dynamic contrast-enhanced; Magnetic resonance imaging; Neovascularization; Spinal neoplasms