title: Exploiting tumor vulnerabilities: NAD(+)-depleting agents combined with anti-tumor drugs as innovative strategy to treat hematological malignancies.
authors.affiliation: a Chair of Hematology, Department of Medicine (DiMI) , University of Genoa, AOU, I.R.C.C.S. San Martino -IST , Genova , Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Cea
authors.affiliation: a Chair of Hematology, Department of Medicine (DiMI) , University of Genoa, AOU, I.R.C.C.S. San Martino -IST , Genova , Italy.
authors.forename: Debora
authors.initials: D
authors.lastname: Soncini
authors.affiliation: a Chair of Hematology, Department of Medicine (DiMI) , University of Genoa, AOU, I.R.C.C.S. San Martino -IST , Genova , Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Gobbi
authors.affiliation: a Chair of Hematology, Department of Medicine (DiMI) , University of Genoa, AOU, I.R.C.C.S. San Martino -IST , Genova , Italy.
authors.forename: Roberto M
authors.initials: RM
authors.lastname: Lemoli
authors.affiliation: a Chair of Hematology, Department of Medicine (DiMI) , University of Genoa, AOU, I.R.C.C.S. San Martino -IST , Genova , Italy.
authors.forename: Antonia
authors.initials: A
authors.lastname: Cagnetta
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000494:pharmacology; D016207:Cytokines / Q000037:antagonists & inhibitors; D019008:Drug Resistance, Neoplasm; D019337:Hematologic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D009243:NAD / Q000378:metabolism*; D054409:Nicotinamide Phosphoribosyltransferase / Q000037:antagonists & inhibitors
chemical_list: D016207:Cytokines; D009243:NAD; D054409:Nicotinamide Phosphoribosyltransferase; C085455:nicotinamide phosphoribosyltransferase, human
keywords: BTK inhibitor; NAD+ depletion; Novel therapies; lymphomas; tumor metabolism