title: Central Nervous System Complications of Oncologic Therapy.
abstract: Traditional and newer agents used to treat cancer can cause significant toxicity to the central nervous system. MRI of the brain and spine is the imaging modality of choice for patients with cancer who develop neurologic symptoms. It is important to be aware of the agents that can cause neurotoxicity and their associated imaging findings so that patients are properly diagnosed and treated. In some instances conventional MRI may not be able to differentiate posttreatment effects from disease progression. In these instances advanced imaging techniques may be helpful, although further research is still needed.
authors.affiliation: Department of Radiology, University Hospital, University of Michigan, #UH-B2 A209, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0030, USA. Electronic address: hoeffner@med.umich.edu.
authors.forename: Ellen G
authors.initials: EG
authors.lastname: Hoeffner
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002493:Central Nervous System Diseases / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000628:therapy; D006801:Humans; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D020258:Neurotoxicity Syndromes / Q000000981:diagnostic imaging / Q000628:therapy
chemical_list: D000970:Antineoplastic Agents
keywords: Cancer; Chemotherapy; Magnetic resonance imaging; Neurotoxicity; Radiation therapy