title: Apoptosis Induction and Imaging of Cadmium-Telluride Quantum Dots with Wogonin in Multidrug-Resistant Leukemia K562/A02 Cell.
abstract: Wogonin (5,7-dihydroxy-8-methoxyflavone) is one of the active components of flavonoids isolated from Scutellariae radix and possesses antitumor effect against leukemia. Cadmium-telluride quantum dots (CdTe-QDs) are a kind of nanoparticles with great potential in functioning as an efficient drug delivery vector in biomedical research. In this study, we investigated the synergistic effect of CdTe-QDs with Wogonin on the induction of apoptosis using drug-resistant human leukemia KA cells. Flow cytometry analysis, assay of morphology under electron microscope, quantitative analysis of tumor volume and micro-CT imaging demonstrated that compared with that by pure CdTe-QDs or wogonin, the apoptosis rate increased sharply when treated wirh CdTe-QDs together with wogonin on KA cells. These results proved that the nanocomposites readily overcame the barrier of drug-resistance and provoked cell apoptosis in vitro and in vivo by facilitating the interaction between wogonin and KA cells. As known to all, it is an inevitable tendency that new effective therapies will take the place of conventional chemotherapy and radiotherapy presenting significant disadvantages. According to this article, CdTe-QD combined with wogonin is a possible alternative for some cancer treatments.
authors.forename: Bin
authors.initials: B
authors.lastname: Huang
authors.forename: Hongyi
authors.initials: H
authors.lastname: Liu
authors.forename: Dongliang
authors.initials: D
authors.lastname: Huang
authors.forename: Xuhua
authors.initials: X
authors.lastname: Mao
authors.forename: Xianyun
authors.initials: X
authors.lastname: Hu
authors.forename: Caiyun
authors.initials: C
authors.lastname: Jiang
authors.forename: Maomao
authors.initials: M
authors.lastname: Pu
authors.forename: Gen
authors.initials: G
authors.lastname: Zhang
authors.forename: Xin
authors.initials: X
authors.lastname: Zeng
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D019187:Cadmium Compounds / Q000378:metabolism*; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D044950:Flavanones / Q000494:pharmacology*; D064593:Heterografts; D006801:Humans; D020014:K562 Cells; D004915:Leukemia, Erythroblastic, Acute / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D008819:Mice, Nude; D046529:Microscopy, Electron, Transmission; D045663:Quantum Dots; D013691:Tellurium / Q000378:metabolism*; D055114:X-Ray Microtomography
chemical_list: D019187:Cadmium Compounds; D044950:Flavanones; D013691:Tellurium; C085514:wogonin; C028337:cadmium telluride