title: Neck dissection and stroke in patients with oral cavity cancer: A population-based cohort study.
abstract: Oral cavity cancer is one of the most common head and neck cancers in the world. The purpose of this study was to determine the incidence and risk factors for stroke after surgery in patients with oral cavity cancer with a focus on the effect of neck dissection.
  
  
  
  Data from the Taiwan National Health Insurance Research Database for newly diagnosed oral cavity cancer between January 1, 2005, and December 31, 2007, were included.
  
  
  
  Neck dissection did not increase the risk of stroke after treatment. Patients with ages older than 44 years, hypertension, diabetes mellitus, coronary artery disease, previous stroke, or postoperative chemoradiotherapy had a significantly higher risk of stroke (p < .05).
  
  
  
  Our data demonstrate that neck dissection does not increase the risk of stroke in patients with oral cavity cancer. Patients have higher risk of stroke after cancer treatment because of their older age, specific comorbidities, and/or type of postoperative treatment. © 2016 Wiley Periodicals, Inc. Head Neck 39: 63-70, 2017.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.|Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.|Institute of Hospital and Health Care Management, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Chia-Fan
authors.initials: CF
authors.lastname: Chang
authors.affiliation: Department of Otolaryngology, National Yang-Ming University Hospital, Yilan County, Taiwan.|Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Yen-Ling
authors.initials: YL
authors.lastname: Kuo
authors.affiliation: Institute of Public Health, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Christy
authors.initials: C
authors.lastname: Pu
authors.affiliation: Institute of Public Health, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Yiing-Jenq
authors.initials: YJ
authors.lastname: Chou
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D015331:Cohort Studies; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000150:complications / Q000401:mortality / Q000628:therapy*; D037981:Neck Dissection; D011183:Postoperative Complications / Q000453:epidemiology*; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology*; D013624:Taiwan
keywords: coronary artery disease; diabetes mellitus; hypertension; neck dissection; oral cavity cancer; stroke