title: Anti-allergic effect ofArtemisiaextract in rats.
abstract: Artemisia apiacea(also known asArtemisia annuaL) is a herb commonly used in traditional Chinese medicine. In the early 1970s, artemisinin was isolated and identified as the active antimalarial ingredient, and thereafter,A. apiaceaand artemisinin have been studied extensively, such as anti-inflammation and antipyresis, antibacteria, antiparasitic and immunosuppression effects ofA. apiaceaextract. The present study investigated the extracts anti-allergic effect obtained from the dried flowering tips ofA. apiaceain rats. A systemic anaphylactic reaction model was induced in rats using compound 48/80.Artemisiaextract was administered 1 h prior to the injection of compound 48/80.Artemisiawas extracted from dried flowering tips ofA. desertiusing 80% ethanol. Subsequently, the systemic anaphylactic shock, histamine release, scratching behavior and vascular permeability induced by compound 48/80 were evaluated. The administration ofArtemisiaextract at 200 and 400 mg/kg doses suppressed the systemic anaphylactic shock induced by compound 48/80 in a dose-dependent manner. Overall, theArtemisiaextract was able to effectively decrease systemic anaphylactic shock, histamine release, scratching behavior and vascular permeability induced by compound 48/80 in a dose-dependent manner.
authors.affiliation: School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Deng
authors.affiliation: School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
authors.forename: Zijun
authors.initials: Z
authors.lastname: Liu
authors.affiliation: School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
authors.forename: Yiwei
authors.initials: Y
authors.lastname: Geng
keywords: allergic models; artemisia extract; systemic anaphylactic reaction