title: Risk factors for cardiopulmonary dysfunction in early-onset severe pre-eclampsia.
abstract: OBJECTIVE
  To explore associations between patient characteristics and cardiopulmonary function among patients with early-onset severe pre-eclampsia being treated with expectant management.
  
  
  METHODS
  The present retrospective study included patients who received expectant management for early-onset pre-eclampsia between January 1 and December 31, 2014 at Shanghai Jiao Tong University School of Medicine, China. Patients were divided into two groups based on cardiopulmonary function, a decompensatory group and a normal group. The clinical characteristics of patients in the two groups were compared by binary logistic regression analysis and using the Student t test.
  
  
  RESULTS
  Data from 93 patients were included in the analysis. Serum creatinine levels (P=0.017), ascites (P=0.001), and increased proteinuria (P=0.015) were associated with decompensation of cardiopulmonary function during early-onset severe pre-eclampsia. Hypoproteinemia was associated with significantly increased odds of ascites occurring (odds ratio 3.16; 95% confidence interval 1.34-7.44) and the mean serum albumin level was higher in patients without ascites (P<0.001).
  
  
  CONCLUSIONS
  Renal insufficiency and ascites were associated with cardiopulmonary dysfunction. Ascites should receive greater medical attention during the expectant management of early-onset severe pre-eclampsia.
authors.affiliation: Department of Obstetrics and Gynecology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
authors.forename: Fei
authors.initials: F
authors.lastname: Guan
authors.affiliation: Department of Obstetrics and Gynecology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Ye
authors.affiliation: Department of Obstetrics and Gynecology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China. Electronic address: linjhuarj@126.com.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Lin
mesh_terms: D000328:Adult; D002681:China; D003404:Creatinine / Q000097:blood; D005260:Female; D005865:Gestational Age; D006321:Heart / Q000503:physiopathology*; D006331:Heart Diseases / Q000503:physiopathology; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D016015:Logistic Models; D008168:Lung / Q000503:physiopathology*; D008171:Lung Diseases / Q000503:physiopathology; D008297:Male; D011225:Pre-Eclampsia / Q000503:physiopathology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D011256:Pregnancy Outcome; D011507:Proteinuria / Q000503:physiopathology; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D003404:Creatinine
keywords: Cardiac function; Early-onset severe pre-eclampsia; Expectant management; Pulmonary function