title: The Effect of Matrix Metalloproteinase-3 on the Prognosis and Biological Behaviour of Meningiomas.
abstract: OBJECTIVE
  To analyse the effect of MMP-3 (Matrix Metalloproteinase Enzyme-3)-one of the extracellular matrix proteins- on the prognosis and biological behaviour of meningiomas.
  
  
  METHODS
  79 cases of meningioma that were operated in our clinic between 2005 and 2010 were retrospectively analysed. Age, sex, preoperative peritumoral edema, histological subtype, grade, Ki-67 expression, MMP-3 staining pattern and recurrence rate were analysed. Pathological preparations were graded according to the WHO (World Health Organisation) 2007 grading system.
  
  
  RESULTS
  Of the MMP-III positive cases; 24 cases (60%) were grade I, 16 cases were grade II. The MMP-3 staining pattern was significantly positive (80%) in grade II meningioma. 14 of the MMP-3 positive cases were atypical meningiomas. Of the 20 cases with high Ki-67 proliferation index (PI), 12 cases (60%) were MMP-3 positive and 8 cases (40%) were MMP-3 negative. Rates of recurrence and preoperative peritumoral edema were high in cases with MMP-3 positivity.
  
  
  CONCLUSIONS
  In this study it was determined that MMP-3 positivity has a strong relationship with meningiomas having an aggressive character. MMP-3 may be used as a proliferation marker for biological behaviour, recurrence rate and prognosis of meningiomas.
authors.affiliation: Namık Kemal University, Faculty of Medicine, Department of Neurosurgery, Tekirdağ, Turkey.
authors.forename: Numan
authors.initials: N
authors.lastname: Karaarslan
authors.forename: Mehmet Sabri
authors.initials: MS
authors.lastname: Gurbuz
authors.forename: Tezcan
authors.initials: T
authors.lastname: Caliskan
authors.forename: Erdogan
authors.initials: E
authors.lastname: Ayan
authors.forename: Fugen Vardar
authors.initials: FV
authors.lastname: Aker
authors.forename: Mehmet Zafer
authors.initials: MZ
authors.lastname: Berkman
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000150:complications / Q000378:metabolism / Q000601:surgery; D004487:Edema / Q000150:complications / Q000473:pathology; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000096:biosynthesis; D008297:Male; D019278:Matrix Metalloproteinase 3 / Q000378:metabolism*; D008577:Meningeal Neoplasms / Q000150:complications / Q000378:metabolism* / Q000473:pathology*; D008579:Meningioma / Q000150:complications / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D012189:Retrospective Studies; D014421:Turkey
chemical_list: D019394:Ki-67 Antigen; D019278:Matrix Metalloproteinase 3