title: Comparison of perinatal outcomes of selective termination in dichorionic twin pregnancies performed at different gestational ages.
abstract: OBJECTIVE
  To determine the perinatal outcomes of selective termination in dichorionic twin pregnancies discordant for major but non-lethal fetal anomalies performed at different gestational ages.
  
  
  METHODS
  Thirty-one dichorionic twin pregnancies that underwent selective termination for discordant major but non-lethal fetal anomalies between January 2004 and February 2015 were retrospectively reviewed. The patients were grouped into three, according to the gestational age at which selective termination of pregnancies was performed; Group 1 (15-19 weeks), Group 2 (20-24 weeks) and Group 3 (30-33 weeks). Perinatal outcomes in all the three groups were reviewed and analyzed.
  
  
  RESULTS
  The overall live birth, term birth and pregnancy loss rate were 93.6%, 54.8% and 9.6%, respectively. The overall live birth rate was 66.6% in Group 1, this rate was 100% in Group 2 and Group 3 (p = 0.01). The rate of pregnancy loss was significantly higher in Group 1 (p = 0.01). The overall preterm delivery rate was 38.7%. While the overall preterm delivery rate was significantly higher in Group 3 (p = 0.04), the rate of extremely and very preterm birth was significantly lower (p = 0.03).
  
  
  CONCLUSIONS
  Late selective feticide performed during the third trimester of pregnancy seems to be a safe approach and can be offered as an alternative method to reduce the total pregnancy loss and extremely and early pre-term birth rates.
authors.affiliation: a Department of Obstetrics and Gynecology , Istanbul University School of Medicine , Istanbul , Turkey and.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Dural
authors.affiliation: a Department of Obstetrics and Gynecology , Istanbul University School of Medicine , Istanbul , Turkey and.
authors.forename: Cenk
authors.initials: C
authors.lastname: Yasa
authors.affiliation: a Department of Obstetrics and Gynecology , Istanbul University School of Medicine , Istanbul , Turkey and.
authors.forename: Ibrahim H
authors.initials: IH
authors.lastname: Kalelioglu
authors.affiliation: a Department of Obstetrics and Gynecology , Istanbul University School of Medicine , Istanbul , Turkey and.
authors.forename: Sultan
authors.initials: S
authors.lastname: Can
authors.affiliation: a Department of Obstetrics and Gynecology , Istanbul University School of Medicine , Istanbul , Turkey and.
authors.forename: Gamze
authors.initials: G
authors.lastname: Yılmaz
authors.affiliation: b Department of Maternal & Fetal Medicine , Kanuni Sultan Suleyman Training and Research Hospital , Istanbul , Turkey.
authors.forename: Aytul
authors.initials: A
authors.lastname: Corbacioglu Esmer
authors.affiliation: a Department of Obstetrics and Gynecology , Istanbul University School of Medicine , Istanbul , Turkey and.
authors.forename: Recep
authors.initials: R
authors.lastname: Has
authors.affiliation: a Department of Obstetrics and Gynecology , Istanbul University School of Medicine , Istanbul , Turkey and.
authors.forename: Atil
authors.initials: A
authors.lastname: Yuksel
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology*; D000328:Adult; D000013:Congenital Abnormalities / Q000175:diagnosis; D005260:Female; D005865:Gestational Age; D006801:Humans; D050498:Live Birth / Q000453:epidemiology*; D011247:Pregnancy; D018607:Pregnancy Reduction, Multifetal / Q000009:adverse effects / Q000379:methods*; D059285:Pregnancy, Twin; D047928:Premature Birth / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control; D012189:Retrospective Studies; D012307:Risk Factors; D047929:Term Birth; D014429:Twins, Dizygotic; D016216:Ultrasonography, Prenatal; D055815:Young Adult
keywords: Selective feticide; pregnancy loss; preterm birth