title: Chemical Composition and Antimicrobial Activity of the Essential Oil from Aerial Parts and Roots of Eryngium barrelieri Boiss. and Eryngium glomeratum Lam. from Tunisia.
abstract: The study of chemical composition and biological activity of unexplored essential oils may open new perspectives on their potential use in facing major health concerns such as drug-resistant infections. The present study investigates the chemical composition and antimicrobial effects of previously unstudied essential oils obtained from genus Eryngium: Eryngium glomeratum Lam. and Eryngium barrelieri Boiss. The chemical compositions of the essential oils from aerial parts and roots of both species were studied using GC and GC/MS analytical technics. The analysis led to the identification of 102 compounds totalizing 85 - 94% of all detected compounds. Essential oils were characterized by the predominance of oxygenated sesquiterpenes. The oils obtained from aerial parts were tested against 36 microbial strains by agar dilution method and showed minimum inhibitory concentrations (MIC) in the range of 2 - 625 μg/ml. A strong antibacterial activity against multiresistant Pseudomonas aeruginosa was observed especially from E. glomeratum essential oil with MIC value up to 2 μg/ml. These findings give significant information about the pharmacological activity of these essential oils, which suggest their potential use to develop new remedies, or as sources of active compounds.
authors.affiliation: Unit of Functional Proteomics and Organic Food Preservation, Higher Institute of Applied Biological Sciences of Tunis, University of Tunis El Manar, Tunis, Tunisia.|Laboratoire Régional de Recherche en Agro-alimentaire et Biotechnologie, Institut Charles Violette, EA 7394, Laboratoire de Pharmacognosie, UFR Pharmacie, Université de Lille, BP 83, 3 Rue du Professeur Laguesse, FR-59006, Lille Cedex.
authors.forename: Ameni
authors.initials: A
authors.lastname: Landoulsi
authors.affiliation: Laboratoire Régional de Recherche en Agro-alimentaire et Biotechnologie, Institut Charles Violette, EA 7394, Laboratoire de Pharmacognosie, UFR Pharmacie, Université de Lille, BP 83, 3 Rue du Professeur Laguesse, FR-59006, Lille Cedex.
authors.forename: Vincent
authors.initials: V
authors.lastname: Roumy
authors.affiliation: Service Commun de Physico-Chimie CUMA, Faculté de Pharmacie, BP 83, 3, Rue du Professeur-Laguesse, FR-59006, Lille Cedex.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Duhal
authors.affiliation: Laboratory of Genetic Biodiversity and Valorisation of Bioressources (LR11ES41), High Institute of Biotechnology, Rue Tahar Haddad, Monastir, 5000, Tunisia.
authors.forename: Fethia Harzallah
authors.initials: FH
authors.lastname: Skhiri
authors.affiliation: Laboratoire Régional de Recherche en Agro-alimentaire et Biotechnologie, Institut Charles Violette, EA 7394, Laboratoire de Pharmacognosie, UFR Pharmacie, Université de Lille, BP 83, 3 Rue du Professeur Laguesse, FR-59006, Lille Cedex.
authors.forename: Céline
authors.initials: C
authors.lastname: Rivière
authors.affiliation: Laboratoire Régional de Recherche en Agro-alimentaire et Biotechnologie, Institut Charles Violette, EA 7394, Laboratoire de Pharmacognosie, UFR Pharmacie, Université de Lille, BP 83, 3 Rue du Professeur Laguesse, FR-59006, Lille Cedex.
authors.forename: Sevser
authors.initials: S
authors.lastname: Sahpaz
authors.affiliation: INSERM U995, UFR Pharmacie, Université Lille 2, FR-59000, Lille.
authors.forename: Christel
authors.initials: C
authors.lastname: Neut
authors.affiliation: Unit of Functional Proteomics and Organic Food Preservation, Higher Institute of Applied Biological Sciences of Tunis, University of Tunis El Manar, Tunis, Tunisia.
authors.forename: Jeannette
authors.initials: J
authors.lastname: Benhamida
authors.affiliation: Laboratoire Régional de Recherche en Agro-alimentaire et Biotechnologie, Institut Charles Violette, EA 7394, Laboratoire de Pharmacognosie, UFR Pharmacie, Université de Lille, BP 83, 3 Rue du Professeur Laguesse, FR-59006, Lille Cedex.
authors.forename: Thierry
authors.initials: T
authors.lastname: Hennebelle
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects; D031049:Eryngium / Q000737:chemistry*; D009822:Oils, Volatile / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D014416:Tunisia
chemical_list: D000900:Anti-Bacterial Agents; D009822:Oils, Volatile
keywords: 
  Eryngium barrelieri
  ; 
  Eryngium glomeratum
  ; 
  Pseudomonas aeruginosa
  ; Antimicrobial activity; Essential oils; Oxygenated sesquiterpenes