title: THERAPIES FOR CROHN'S DISEASE: a clinical update.
abstract: The main objectives of clinical therapy in Crohn's disease are clinical and endoscopic remission without the use of corticosteroids for long periods of time, prevention of hospitalization and surgery, and improvement of quality of life. The main limitation of drug therapy is the loss of response over the long term, which makes incorporation of new drugs to the therapeutic arsenal necessary. This review analyses the main drugs currently used in clinical treatment of Crohn's disease.
authors.affiliation: Disciplina de Coloproctologia, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (FMUSP), Brasil.
authors.forename: Carlos Walter
authors.initials: CW
authors.lastname: Sobrado
authors.affiliation: Departamento de Cirurgia, Unidade de Coloproctologia, Universidade de Campinas (UNICAMP), Brasil.
authors.forename: Raquel Franco
authors.initials: RF
authors.lastname: Leal
authors.affiliation: Disciplina de Coloproctologia, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (FMUSP), Brasil.
authors.forename: Lucas Faraco
authors.initials: LF
authors.lastname: Sobrado
mesh_terms: D010131:Aminosalicylic Acid / Q000008:administration & dosage / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001691:Biological Therapy / Q000592:standards*; D003424:Crohn Disease / Q000188:drug therapy / Q000628:therapy*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D011239:Prednisolone / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D010131:Aminosalicylic Acid; D011239:Prednisolone