title: [Transformation of secondary myelodysplastic syndrome to atypical chronic myeloid leukemia in a female patient with acute myeloid leukemia].
abstract: Secondary myeloid neoplasia may be a complication of intensive cytostatic therapy. The most common types of secondary neoplasias are acute myeloid leukemia and myelodysplastic syndrome. The development of secondary atypical chronic myeloid leukemia (aCML) is an extremely rare phenomenon. The paper describes transformation of secondary myelodysplastic syndrome to aCML 6 months after its diagnosis. The development of aCML was accompanied by additional chromosomal aberration as monosomy of chromosome 17. No mutations in the JAK2, MPL, and CalR genes were detected. It is concluded that the clinical course of secondary myeloid neoplasias is variable.
authors.affiliation: Russian Research Institute of Hematology and Transfusiology, Federal Biomedical Agency of Russia, Moscow, Russia.
authors.forename: S V
authors.initials: SV
authors.lastname: Gritsaev
authors.affiliation: Russian Research Institute of Hematology and Transfusiology, Federal Biomedical Agency of Russia, Moscow, Russia.
authors.forename: I I
authors.initials: II
authors.lastname: Kostroma
authors.affiliation: Russian Research Institute of Hematology and Transfusiology, Federal Biomedical Agency of Russia, Moscow, Russia.
authors.forename: I M
authors.initials: IM
authors.lastname: Zapreev
authors.affiliation: Russian Research Institute of Hematology and Transfusiology, Federal Biomedical Agency of Russia, Moscow, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Shmidt
authors.affiliation: Russian Research Institute of Hematology and Transfusiology, Federal Biomedical Agency of Russia, Moscow, Russia.
authors.forename: S A
authors.initials: SA
authors.lastname: Tiranova
authors.affiliation: Russian Research Institute of Hematology and Transfusiology, Federal Biomedical Agency of Russia, Moscow, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Balashova
authors.affiliation: Russian Research Institute of Hematology and Transfusiology, Federal Biomedical Agency of Russia, Moscow, Russia.
authors.forename: I S
authors.initials: IS
authors.lastname: Martynkevich
authors.affiliation: Russian Research Institute of Hematology and Transfusiology, Federal Biomedical Agency of Russia, Moscow, Russia.
authors.forename: Zh V
authors.initials: ZV
authors.lastname: Chubukina
authors.affiliation: Russian Research Institute of Hematology and Transfusiology, Federal Biomedical Agency of Russia, Moscow, Russia.
authors.forename: N Yu
authors.initials: NY
authors.lastname: Semenova
authors.affiliation: Russian Research Institute of Hematology and Transfusiology, Federal Biomedical Agency of Russia, Moscow, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Chechetkin
mesh_terms: D000368:Aged; D002869:Chromosome Aberrations; D002886:Chromosomes, Human, Pair 17; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics / Q000473:pathology*; D054438:Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*; D009190:Myelodysplastic Syndromes / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*