title: Six plant extracts delay yeast chronological aging through different signaling pathways.
abstract: Our recent study has revealed six plant extracts that slow yeast chronological aging more efficiently than any chemical compound yet described. The rate of aging in yeast is controlled by an evolutionarily conserved network of integrated signaling pathways and protein kinases. Here, we assessed how single-gene-deletion mutations eliminating each of these pathways and kinases affect the aging-delaying efficiencies of the six plant extracts. Our findings imply that these extracts slow aging in the following ways: 1) plant extract 4 decreases the efficiency with which the pro-aging TORC1 pathway inhibits the anti-aging SNF1 pathway; 2) plant extract 5 mitigates two different branches of the pro-aging PKA pathway; 3) plant extract 6 coordinates processes that are not assimilated into the network of presently known signaling pathways/protein kinases; 4) plant extract 8 diminishes the inhibitory action of PKA on SNF1; 5) plant extract 12 intensifies the anti-aging protein kinase Rim15; and 6) plant extract 21 inhibits a form of the pro-aging protein kinase Sch9 that is activated by the pro-aging PKH1/2 pathway.
authors.affiliation: Department of Biology, Concordia University, Montreal, Quebec, Canada.
authors.forename: Vicky
authors.initials: V
authors.lastname: Lutchman
authors.affiliation: Department of Biology, Concordia University, Montreal, Quebec, Canada.
authors.forename: Pamela
authors.initials: P
authors.lastname: Dakik
authors.affiliation: Department of Biology, Concordia University, Montreal, Quebec, Canada.
authors.forename: Mélissa
authors.initials: M
authors.lastname: McAuley
authors.affiliation: Department of Biology, Concordia University, Montreal, Quebec, Canada.
authors.forename: Berly
authors.initials: B
authors.lastname: Cortes
authors.affiliation: Department of Biology, Concordia University, Montreal, Quebec, Canada.
authors.forename: George
authors.initials: G
authors.lastname: Ferraye
authors.affiliation: Department of Biology, Concordia University, Montreal, Quebec, Canada.
authors.forename: Leonid
authors.initials: L
authors.lastname: Gontmacher
authors.affiliation: Department of Biology, Concordia University, Montreal, Quebec, Canada.
authors.forename: David
authors.initials: D
authors.lastname: Graziano
authors.affiliation: Department of Biology, Concordia University, Montreal, Quebec, Canada.
authors.forename: Fatima-Zohra
authors.initials: FZ
authors.lastname: Moukhariq
authors.affiliation: Idunn Technologies Inc., Rosemere, Quebec, Canada.
authors.forename: Éric
authors.initials: É
authors.lastname: Simard
authors.affiliation: Department of Biology, Concordia University, Montreal, Quebec, Canada.
authors.forename: Vladimir I
authors.initials: VI
authors.lastname: Titorenko
mesh_terms: D000375:Aging / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D010936:Plant Extracts; D029701:Saccharomyces cerevisiae Proteins
keywords: Gerotarget; aging-delaying chemical compounds; cellular aging; longevity; plant extracts; yeast