title: Metabolic Precision Medicines: Curing POMC Deficiency.
abstract: Pro-opiomelanocortin deficiency is a rare cause of severe intractable obesity. Two patients have experienced dramatic weight loss in response to setmelanotide, a melanocortin-4 receptor activator. The drug has potential in broader populations, but caution is warranted as it may act at other melanocortin receptors.
authors.affiliation: Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg 85764, Germany; German Center for Diabetes Research (DZD), Neuherberg 85764, Germany. Electronic address: timo.mueller@helmholtz-muenchen.de.
authors.forename: Timo D
authors.initials: TD
authors.lastname: Müller
authors.affiliation: Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg 85764, Germany; German Center for Diabetes Research (DZD), Neuherberg 85764, Germany; Division of Metabolic Diseases, Department of Medicine, Technische Universität München, Munich 85748, Germany. Electronic address: matthias.tschoep@helmholtz-muenchen.de.
authors.forename: Matthias H
authors.initials: MH
authors.lastname: Tschöp
authors.affiliation: University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK. Electronic address: so104@medschl.cam.ac.uk.
authors.forename: Stephen
authors.initials: S
authors.lastname: O'Rahilly
mesh_terms: D006801:Humans; D009765:Obesity; D057285:Precision Medicine; D011333:Pro-Opiomelanocortin / Q000172:deficiency*; D044105:Receptor, Melanocortin, Type 4; D044101:Receptors, Melanocortin
chemical_list: D044105:Receptor, Melanocortin, Type 4; D044101:Receptors, Melanocortin; D011333:Pro-Opiomelanocortin