title: MYEOVgene overexpression in primary plasma cell leukemia with t(11;14)(q13;q32).
abstract: Primary plasma cell leukemia (pPCL) is an uncommon form of plasma cell dyscrasia, and the most aggressive of the human monoclonal gammopathies. The t(11;14)(q13;q32) rearrangement is the most common alteration in pPCL, promotingcyclin D1(CCND1) gene overexpression caused by its juxtaposition with theimmunoglobulin heavy locuschromosome region. Themyeloma overexpressed(MYEOV) gene maps very close to theCCND1gene on chromosome 11, but its overexpression is rarely observed in multiple myeloma. The present study describes a case of pPCL with t(11;14) characterized by a breakpoint on der(11), unlike the one usually observed. Droplet digital polymerase chain reaction analysis revealed overexpression ofCCND1andMYEOV. To the best of our knowledge,MYEOVgene overexpression has never been previously described in pPCL.
authors.affiliation: Department of Emergency and Organ Transplantation, Hematology Section, University of Bari, I-70124 Bari, Italy.
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Coccaro
authors.affiliation: Department of Emergency and Organ Transplantation, Hematology Section, University of Bari, I-70124 Bari, Italy.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Tota
authors.affiliation: Department of Emergency and Organ Transplantation, Hematology Section, University of Bari, I-70124 Bari, Italy.
authors.forename: Luisa
authors.initials: L
authors.lastname: Anelli
authors.affiliation: Department of Emergency and Organ Transplantation, Hematology Section, University of Bari, I-70124 Bari, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Zagaria
authors.affiliation: Department of Emergency and Organ Transplantation, Hematology Section, University of Bari, I-70124 Bari, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Casieri
authors.affiliation: Department of Emergency and Organ Transplantation, Hematology Section, University of Bari, I-70124 Bari, Italy.
authors.forename: Angelo
authors.initials: A
authors.lastname: Cellamare
authors.affiliation: Department of Emergency and Organ Transplantation, Hematology Section, University of Bari, I-70124 Bari, Italy.
authors.forename: Crescenzio Francesco
authors.initials: CF
authors.lastname: Minervini
authors.affiliation: Department of Emergency and Organ Transplantation, Hematology Section, University of Bari, I-70124 Bari, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Minervini
authors.affiliation: Department of Emergency and Organ Transplantation, Hematology Section, University of Bari, I-70124 Bari, Italy.
authors.forename: Cosimo
authors.initials: C
authors.lastname: Cumbo
authors.affiliation: Department of Emergency and Organ Transplantation, Hematology Section, University of Bari, I-70124 Bari, Italy.
authors.forename: Luciana
authors.initials: L
authors.lastname: Impera
authors.affiliation: Department of Emergency and Organ Transplantation, Hematology Section, University of Bari, I-70124 Bari, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Brunetti
authors.affiliation: Department of Emergency and Organ Transplantation, Hematology Section, University of Bari, I-70124 Bari, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Orsini
authors.affiliation: Department of Emergency and Organ Transplantation, Hematology Section, University of Bari, I-70124 Bari, Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Parciante
authors.affiliation: Department of Emergency and Organ Transplantation, Hematology Section, University of Bari, I-70124 Bari, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Mestice
authors.affiliation: Department of Emergency and Organ Transplantation, Hematology Section, University of Bari, I-70124 Bari, Italy.
authors.forename: Giorgina
authors.initials: G
authors.lastname: Specchia
authors.affiliation: Department of Emergency and Organ Transplantation, Hematology Section, University of Bari, I-70124 Bari, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Albano
keywords: B-Raf V600E mutation; CCND1 gene; MYEOV gene; ddPCR; primary plasma cell leukemia; t(11;14)