title: Fibroblast growth factor-23 and phosphorus related factors in young Japanese women: a cross-sectional study.
abstract: Phosphorus homeostasis is determined by dietary intake, intestinal absorption, and renal tubular reabsorption of phosphorus. Serum fibroblast growth factor-23 (FGF-23) is considered to be a sensitive early biomarker of disordered phosphorus metabolism in both patients with chronic kidney diseases and healthy subjects. However, the number of studies evaluating serum FGF-23 concentrations in healthy subjects is limited. The objective of this cross-sectional study was to examine the relationship between serum FGF-23 concentrations and phosphorus related factors in 182 young Japanese women (mean age, 19.5±0.4 years). We found that higher serum concentrations of inorganic phosphorus and lower serum concentrations of 1,25-dihydroxy vitamin D as well as lower fat but higher phosphorus and calcium intake were weakly but significantly associated with high serum concentrations of FGF-23, adjusted for postmenarcheal age and body weight. These results suggested that in young Japanese women, serum FGF-23 might be indicative of phosphorus nutrition status. However, it is worthy of note that maturity factors, including postmenarcheal age and physical attributes, such as body weight, might be related to serum FGF-23 concentrations.
authors.affiliation: Laboratory of Administrative Dietetics, Kagawa Nutrition University, Saitama, Japan. Email: sitoh@eiyo.ac.jp; ishida@eiyo.ac.jp.
authors.forename: Sanae
authors.initials: S
authors.lastname: Ito
authors.affiliation: Laboratory of Administrative Dietetics, Kagawa Nutrition University, Saitama, Japan.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Ishida
authors.affiliation: Laboratory of Physiological Nutrition, Kagawa Nutrition University, Saitama, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Uenishi
mesh_terms: D015415:Biomarkers / Q000097:blood; D015519:Bone Density; D002118:Calcium / Q000097:blood; D002136:Calcium, Dietary / Q000008:administration & dosage; D003430:Cross-Sectional Studies; D004041:Dietary Fats / Q000008:administration & dosage; D005260:Female; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood*; D006801:Humans; D007564:Japan; D016014:Linear Models; D008572:Menarche; D009752:Nutritional Status; D010758:Phosphorus / Q000008:administration & dosage / Q000097:blood* / Q000172:deficiency; D016226:Phosphorus, Dietary / Q000008:administration & dosage; D055815:Young Adult
chemical_list: D015415:Biomarkers; D002136:Calcium, Dietary; D004041:Dietary Fats; C000717427:FGF23 protein, human; D016226:Phosphorus, Dietary; D010758:Phosphorus; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D002118:Calcium