title: Automated volumetric segmentation of retinal fluid on optical coherence tomography.
abstract: We propose a novel automated volumetric segmentation method to detect and quantify retinal fluid on optical coherence tomography (OCT). The fuzzy level set method was introduced for identifying the boundaries of fluid filled regions on B-scans (x and y-axes) and C-scans (z-axis). The boundaries identified from three types of scans were combined to generate a comprehensive volumetric segmentation of retinal fluid. Then, artefactual fluid regions were removed using morphological characteristics and by identifying vascular shadowing with OCT angiography obtained from the same scan. The accuracy of retinal fluid detection and quantification was evaluated on 10 eyes with diabetic macular edema. Automated segmentation had good agreement with manual segmentation qualitatively and quantitatively. The fluid map can be integrated with OCT angiogram for intuitive clinical evaluation.
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA; Shandong Province Key Laboratory of Medical Physics and Image Processing Technology, Shandong Normal University, Jinan, 250014, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA.
authors.forename: Miao
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA.
authors.forename: Alex D
authors.initials: AD
authors.lastname: Pechauer
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA.
authors.forename: Liang
authors.initials: L
authors.lastname: Liu
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA.
authors.forename: Thomas S
authors.initials: TS
authors.lastname: Hwang
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Wilson
authors.affiliation: Shandong Province Key Laboratory of Medical Physics and Image Processing Technology, Shandong Normal University, Jinan, 250014, China.
authors.forename: Dengwang
authors.initials: D
authors.lastname: Li
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA.
authors.forename: Yali
authors.initials: Y
authors.lastname: Jia
keywords: (100.0100) Image processing; (100.2960) Image analysis; (110.4500) Optical coherence tomography; (170.4470) Ophthalmology