title: Natural Flavonoids as Promising Analgesic Candidates: A Systematic Review.
abstract: Due to the chemical structural diversity and various analgesic mechanisms, an increasing number of studies indicated that some flavonoids from medicinal plants could be promising candidates for new natural analgesic drugs, which attract high interests of advanced users and academic researchers. The aim of this systematic review is to report flavonoids and its derivatives as new analgesic candidates based on the pharmacological evidences. Sixty-four papers were found concerning the potential analgesic activity of 46 flavonoids. In this case, the evidence for analgesic activity of flavonoids and total flavonoids was investigated. Meanwhile, the corresponding analgesic mechanism of flavonoids was discussed by generalizing and analyzing the current publications. Based on this review, the conclusion can be drawn that some flavonoids are promising candidates for painful conditions and deserve particular attention in further research and development.
authors.affiliation: School of Pharmacy, Second Military Medical University, Shanghai, 200433, P. R. China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Xiao
authors.affiliation: School of Pharmacy, Second Military Medical University, Shanghai, 200433, P. R. China.|School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, 350108, Fujian, P. R. China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Wang
authors.affiliation: School of Pharmacy, Second Military Medical University, Shanghai, 200433, P. R. China.|School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, 350108, Fujian, P. R. China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Gui
authors.affiliation: School of Pharmacy, Second Military Medical University, Shanghai, 200433, P. R. China.
authors.forename: Lu
authors.initials: L
authors.lastname: Chen
authors.affiliation: School of Pharmacy, Second Military Medical University, Shanghai, 200433, P. R. China.
authors.forename: Baokang
authors.initials: B
authors.lastname: Huang
mesh_terms: D000700:Analgesics / Q000737:chemistry / Q000494:pharmacology*; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D015220:Calcium Channels / Q000378:metabolism; D002490:Central Nervous System / Q000187:drug effects*; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism; D011453:Prostaglandins / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism
chemical_list: D000700:Analgesics; D001688:Biological Products; D015220:Calcium Channels; D005419:Flavonoids; D011453:Prostaglandins; D009569:Nitric Oxide; D012701:Serotonin
keywords: Analgesic activity; Flavonoids; Mechanism; Quercetin