title: Effect of Aerobic Exercise Training on MDA and TNF- α Levels in Patients with Type 2 Diabetes Mellitus.
abstract: Objective. Diabetes mellitus (DM) is associated with low-grade inflammation. The benefits of regular exercise for the DM are well established, whereas less is known about the impact of aerobic exercise on malondialdehyde (MDA) and tumor necrosis factor-alpha (TNF-α) in the DM. Methods. We randomised 64 participants, who do not exercise regularly, without any diabetic chronic complications in parallel to 12 weeks of aerobic exercise (three times per week, n = 31) and no exercise (control; n = 33). Plasma levels of soluble TNF-α and MDA levels were measured before-after physical training programme and control group. Results. Sixty-four patients with type 2 diabetes mellitus were analysed. When comparing the two groups of patients with age, gender, hemoglobin A1c (HbA1c) levels, lipid profile, waist circumference, body mass index (BMI) and class of treatment for diabetes were not different between groups. While soluble TNF-α remained essentially unaffected by physical training, plasma concentrations of MDA markedly decreased (P < 0.05); physical training also decreased body weight, waist circumference, and blood pressure (P < 0.05). Conclusion. Exercise training favorably affected body weight, waist circumference, and blood pressure. A three-weekly, 12-week, aerobic-training programme, without a concomitant weight loss diet, was associated with significant decrease in MDA levels in type 2 diabetic individuals.
authors.affiliation: Department of Internal Medicine, Develi State Hospital, 38400 Kayseri, Turkey.
authors.forename: Mihriban
authors.initials: M
authors.lastname: Arslan
authors.affiliation: Division of Endocrinology and Metabolism, Faculty of Medicine, Selcuk University, 42250 Konya, Turkey.
authors.forename: Suleyman Hilmi
authors.initials: SH
authors.lastname: Ipekci
authors.affiliation: Division of Endocrinology and Metabolism, Faculty of Medicine, Selcuk University, 42250 Konya, Turkey.
authors.forename: Levent
authors.initials: L
authors.lastname: Kebapcilar
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Baskent University, 42080 Konya, Turkey.
authors.forename: Nesrin
authors.initials: N
authors.lastname: Dogan Dede
authors.affiliation: Department of Biochemistry, Meram School of Medicine, Necmettin Erbakan University, 42090 Konya, Turkey.
authors.forename: Sevil
authors.initials: S
authors.lastname: Kurban
authors.affiliation: Department of Biochemistry, Meram School of Medicine, Necmettin Erbakan University, 42090 Konya, Turkey.
authors.forename: Ekrem
authors.initials: E
authors.lastname: Erbay
authors.affiliation: Division of Endocrinology and Metabolism, Faculty of Medicine, Istanbul Bilim University, 34394 Istanbul, Turkey.
authors.forename: Mustafa Sait
authors.initials: MS
authors.lastname: Gonen