title: Two Additional Acute Nonlymphocytic Leukemia Patients with a Sole Chromosome Abnormality of Trisomy 4.
abstract: We report two cases of acute nonlymphocytic leukemia (ANLL) in which the circulating leukemic cells showed trisomy of chromosome 4 as the sole cytogenetic abnormality. Trisomy 4 is rarely found in hematopoietic neoplasia and until now the few reported patients had ANLL or myelodysplastic syndrome (MDS). In these two ANLL patients with trisomy 4 (FAB-M2 and M4), we were unable to obtain information on exposure to mutagenic/carcinogenic agents. Furthermore, both of them did not manifest underlying dysplastic changes in the bone marrow and also had cells with a normal karyotype. In addition the presence of cells with trisomy 4 without associated marrow dysplasia indicates that this karyotypic change may also occur in some ANLL patients without preexisting MDS.
authors.affiliation: a First Department of Internal Medicine, Tokyo Medical College, Tokyo, 160, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tauchi
authors.affiliation: a First Department of Internal Medicine, Tokyo Medical College, Tokyo, 160, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ohyashiki
authors.affiliation: b Chromosome Laboratory [A.K.], Tokyo Medical College, Tokyo, 160, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Kodama
authors.affiliation: a First Department of Internal Medicine, Tokyo Medical College, Tokyo, 160, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Iwabuchi
authors.affiliation: a First Department of Internal Medicine, Tokyo Medical College, Tokyo, 160, Japan.
authors.forename: J H
authors.initials: JH
authors.lastname: Ohyashiki
authors.affiliation: a First Department of Internal Medicine, Tokyo Medical College, Tokyo, 160, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Toyama
keywords: ANLL; chromosome aberration; trisomy 4