title: Long-Term Mangiferin Extract Treatment Improves Central Pathology and Cognitive Deficits in APP/PS1 Mice.
abstract: Alzheimer's disease (AD) is the most common cause of dementia; however, available treatments have had limited success. Therefore AD patients are in tremendous need of new pharmacological approaches that may delay or slow the progression of the disease. In addition to the classical neuropathological features, immunological and inflammatory processes are also involved in AD pathogenesis. Naturally occurring compounds, such as Mangifera indica Linn (MGF) extracts have previously been shown to significantly reduce peripheral inflammatory processes. In order to explore the role of MGF in AD central pathology, we have orally treated APP/PS1 mice for 22 weeks. While MGF did not affect amyloid pathology, tau hyperphosphorylation was significantly reduced in the cortex and hippocampus. Also, inflammatory processes, measured by microglia and astrocyte burdens, were diminished in MGF-treated mice. Moreover, neuronal morphological alterations, such as abnormal neurite curvature and dystrophies, highly increased in APP/PS1 mice, were significantly ameliorated by long-term MGF treatment. Reduction of all these pathological features were accompanied by compelling improvements of episodic and spatial memory in APP/PS1 mice treated with MGF. Altogether our data suggest that MGF may provide a useful tool to target different aspects of AD pathology and could lead to more effective future therapeutic or preventive strategies.
authors.affiliation: Division of Physiology, School of Medicine, Universidad de Cadiz, Plaza Fragela sn, 4 piso 410, Cadiz, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Infante-Garcia
authors.affiliation: Division of Physiology, School of Medicine, Universidad de Cadiz, Plaza Fragela sn, 4 piso 410, Cadiz, Spain.
authors.forename: Juan Jose
authors.initials: JJ
authors.lastname: Ramos-Rodriguez
authors.affiliation: Division of Physiology, School of Medicine, Universidad de Cadiz, Plaza Fragela sn, 4 piso 410, Cadiz, Spain.
authors.forename: Irene
authors.initials: I
authors.lastname: Delgado-Olmos
authors.affiliation: Division of Physiology, School of Medicine, Universidad de Cadiz, Plaza Fragela sn, 4 piso 410, Cadiz, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Gamero-Carrasco
authors.affiliation: Department of Chemical Engineering, Food Technology and Environmental Technologies, Science Faculty, Campus de Excelencia International Agroalimentario ceiA3, Universidad de Cadiz, Puerto Real, Spain.
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Fernandez-Ponce
authors.affiliation: Department of Chemical Engineering, Food Technology and Environmental Technologies, Science Faculty, Campus de Excelencia International Agroalimentario ceiA3, Universidad de Cadiz, Puerto Real, Spain.
authors.forename: Lourdes
authors.initials: L
authors.lastname: Casas
authors.affiliation: Department of Chemical Engineering, Food Technology and Environmental Technologies, Science Faculty, Campus de Excelencia International Agroalimentario ceiA3, Universidad de Cadiz, Puerto Real, Spain.
authors.forename: Casimiro
authors.initials: C
authors.lastname: Mantell
authors.affiliation: Division of Physiology, School of Medicine, Universidad de Cadiz, Plaza Fragela sn, 4 piso 410, Cadiz, Spain. monica.garcia@uca.es.
authors.forename: Monica
authors.initials: M
authors.lastname: Garcia-Alloza
mesh_terms: D000544:Alzheimer Disease / Q000150:complications / Q000188:drug therapy* / Q000473:pathology*; D000682:Amyloid / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D003072:Cognition Disorders / Q000150:complications / Q000188:drug therapy* / Q000473:pathology*; D007249:Inflammation / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D031022:Mangifera; D051379:Mice; D016501:Neurites / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D053764:Presenilin-1 / Q000378:metabolism*; D044004:Xanthones / Q000494:pharmacology / Q000627:therapeutic use*; D016875:tau Proteins / Q000378:metabolism
chemical_list: D000682:Amyloid; D016229:Amyloid beta-Peptides; C501277:Mangifera indica extract; D010936:Plant Extracts; D053764:Presenilin-1; D044004:Xanthones; D016875:tau Proteins; C013592:mangiferin
keywords: Alzheimer’s disease; Amyloid-beta; Cognitive impairment; Mangiferin; Microglia; Tau