title: How sesquiterpenes modulate signaling cascades in cancers.
abstract: Data obtained from high-throughput technologies has started to shed light on the interplay between signal transduction cascades and chromatin modifications thus adding another layer of complexity to the already complex regulation of the protein network. Based on the insights gleaned from almost a decade of research, it has now been convincingly revealed that sesquiterpenes effectively modulated different intracellular signaling cascades in different cancers. In this review we summarize how sesquiterpenes mediated Wnt, Shh, Notch and TRAIL induced signaling cascades.
authors.affiliation: PMAS-Arid Agriculture University Department of zoology Rawalpindi Pakistan.
authors.forename: S
authors.initials: S
authors.lastname: Jabeen
authors.affiliation: GCU Department of Chemistry Lahore Pakistan.
authors.forename: M Z
authors.initials: MZ
authors.lastname: Qureshi
authors.affiliation: Yeditepe University Medical School Istanbul Turkey.
authors.forename: R
authors.initials: R
authors.lastname: Attar
authors.affiliation: QAU Department of Microbiology, Faculty of Biological Sciences Islamabad Pakistan.
authors.forename: A
authors.initials: A
authors.lastname: Aslam
authors.affiliation: International Islamic University Department of Bioinformatics and Biotechnology Islamabad Pakistan.
authors.forename: S
authors.initials: S
authors.lastname: Kanwal
authors.affiliation: International Islamic University Department of Bioinformatics and Biotechnology Islamabad Pakistan.
authors.forename: S
authors.initials: S
authors.lastname: Khalid
authors.affiliation: Pearl Continental Chief Dietitian Lahore Pakistan.
authors.forename: J M
authors.initials: JM
authors.lastname: Qureshi
authors.affiliation: Istanbul University Faculty of Science, Botany Department Istanbul Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Aras Perk
authors.affiliation: Rashid Latif Medical College Laboratory for Translational Oncology and Personalized Medicine Lahore Pakistan ammadfarooqi@rlmclahore.com.
authors.forename: A A
authors.initials: AA
authors.lastname: Farooqi
authors.affiliation: Institute of Biomedical and genetic Engineering (IBGE) Islamabad Pakistan.
authors.forename: M
authors.initials: M
authors.lastname: Ismail
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D006801:Humans; D009363:Neoplasm Proteins / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D012717:Sesquiterpenes / Q000494:pharmacology / Q000627:therapeutic use*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D009363:Neoplasm Proteins; D012717:Sesquiterpenes