title: Unusual ocular presentations of ocular phaeohyphomycosis.
abstract: PurposePhaeohyphomycosis are melanin-containing fungi that rarely infect the eye. We describe three cases of ocular infection with some unusual clinical features.MethodsSeries of three case reports describing three different presentations of phaeohyphomycosis of the eye, their histopathology, and management.ResultsCase 1 mimicked an inflamed conjunctival naevus and was excised on this basis, revealing a conjunctival retention cyst containing pigmented fungal hyphae. Case 2 showed a wooden foreign body incidentally associated with pigmented fungal hyphae, which required treatment with topical antifungal therapy. Case 3 clinically was thought to be a perforated uveal melanoma and comprised an extensive plaque of pigmented fungal hyphae over ulcerated cornea.ConclusionThe pigmented melanin containing hyphae of phaeohyphomycosis mimicked melanocytic lesions in two cases and was an incidental finding in the context of a surface foreign body.
authors.affiliation: Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: A
authors.initials: A
authors.lastname: Maudgil
authors.affiliation: Department of Ophthalmology, Newcastle Eye Centre, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
authors.forename: Z
authors.initials: Z
authors.lastname: Johnson
authors.affiliation: Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: N
authors.initials: N
authors.lastname: Rogers
authors.affiliation: Department of Histopathology, National Specialist Ophthalmic Pathology Service (NSOPS), Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: H S
authors.initials: HS
authors.lastname: Mudhar
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D002648:Child; D003229:Conjunctival Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D003320:Corneal Ulcer / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D003560:Cysts / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D003937:Diagnosis, Differential; D005129:Eye Foreign Bodies / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D015821:Eye Infections, Fungal / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D005260:Female; D015745:Granuloma, Foreign-Body / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D060446:Phaeohyphomycosis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D065819:Voriconazole / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D065819:Voriconazole