title: Prorenin/renin receptor blockade promotes a healthy fat distribution in obese mice.
abstract: Administration of the handle region peptide (HRP), a (pro)renin receptor blocker, decreases body weight gain and visceral adipose tissue (VAT) in high-fat/high-carbohydrate (HF/HC) diet-fed mice. The objective of this study was to elucidate potential mechanisms implicated in these observations.
  
  
  
  Mice were given a normal or a HF/HC diet along with saline or HRP for 10 weeks.
  
  
  
  In HF/HC-fed mice, HRP increased the expression of several enzymes implicated in lipogenesis and lipolysis in subcutaneous fat (SCF) while the expression of the enzyme implicated in the last step of lipogenesis decreased in VAT. A reduction was also observed in circulating free fatty acids in these animals which was accompanied by normalized adipocyte size in VAT and increased adipocyte size in SCF. ''Beiging'' is the evolution of a white adipose tissue toward a brown-like phenotype characterized by an increased mitochondrial density and small lipid droplets. HRP increased the expression of' "beiging" markers in SCF of HF/HC diet-fed mice.
  
  
  
  HRP treatment may favor healthy fat storage in SCF by activating a triglyceride/free fatty acid cycling and "beiging," which could explain the body weight and fat mass reduction.
authors.affiliation: Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM).|Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Québec, Canada.|Montreal Diabetes Research Center, Montréal, Québec, Canada.
authors.forename: Paul
authors.initials: P
authors.lastname: Tan
authors.affiliation: Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Québec, Canada.
authors.forename: Carolane
authors.initials: C
authors.lastname: Blais
authors.affiliation: Institut de Recherches Cliniques de Montréal, Montréal, Québec, Canada.
authors.forename: Thi M-D
authors.initials: TM
authors.lastname: Nguyen
authors.affiliation: Institut de Recherches Cliniques de Montréal, Montréal, Québec, Canada.|Department of Pharmacology, Université de Montréal, Montréal, Québec, Canada.
authors.forename: Peter W
authors.initials: PW
authors.lastname: Schiller
authors.affiliation: Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM).|Department of Medicine, Université de Montréal, Montréal, Québec, Canada.
authors.forename: Jolanta
authors.initials: J
authors.lastname: Gutkowska
authors.affiliation: Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM).|Montreal Diabetes Research Center, Montréal, Québec, Canada.|Department of Kinesiology, Université de Montréal, Montréal, Québec, Canada.
authors.forename: Julie L
authors.initials: JL
authors.lastname: Lavoie
mesh_terms: D017667:Adipocytes / Q000378:metabolism; D000273:Adipose Tissue / Q000378:metabolism; D052436:Adipose Tissue, White / Q000378:metabolism; D000818:Animals; D059305:Diet, High-Fat; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D050155:Lipogenesis / Q000235:genetics; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D009765:Obesity / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism / Q000502:physiology*; D012083:Renin / Q000378:metabolism*; D012084:Renin-Angiotensin System / Q000502:physiology*; D014280:Triglycerides / Q000378:metabolism; D000093342:Prorenin Receptor
chemical_list: D005230:Fatty Acids, Nonesterified; D011956:Receptors, Cell Surface; D014280:Triglycerides; D012083:Renin; D000093342:Prorenin Receptor