title: Isocoumarin Derivatives from the Sponge-Associated Fungus Peyronellaea glomerata with Antioxidant Activities.
abstract: Chemical examination of the solid culture of the sponge-associated fungus Peyronellaea glomerata led to the isolation of five new isocoumarins, namely peyroisocoumarins A - D (1 - 4) and isocitreoisocoumarinol (5), together with 13 known analogues (6 - 18). Their structures were determined on the basis of extensive spectroscopic analyses, including the modified Mosher's method for the configurational assignments. Peyroisocoumarins A and B were characterized by the presence of Cl-atom at pentane chain, which were unusual in isocoumarin derivatives. The ARE reporter assay revealed that peyroisocoumarins A, B, and D exerted potent ARE activation in HepG2C8 cells, while the preliminary analyses of structure-activity relationship was discussed.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, P. R. China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, P. R. China.
authors.forename: Dong
authors.initials: D
authors.lastname: Liu
authors.affiliation: Institute für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universität Düsseldorf, Universitätsstr. 1, Geb.26.23, DE-40225, Düsseldorf.
authors.forename: Peter
authors.initials: P
authors.lastname: Proksch
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, P. R. China.
authors.forename: Siwang
authors.initials: S
authors.lastname: Yu
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, P. R. China. whlin@bjmu.edu.cn.
authors.forename: Wenhan
authors.initials: W
authors.lastname: Lin
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005658:Fungi / Q000737:chemistry* / Q000378:metabolism; D056945:Hep G2 Cells; D006801:Humans; D049934:Isocoumarins / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D008156:Luciferases / Q000378:metabolism*; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000975:Antioxidants; D049934:Isocoumarins; D008156:Luciferases
keywords: 
  Peyronellaea glomerata
  ; ARE luciferase activation; Fungus; Isocoumarin; Peyroisocoumarins A - D