title: Construction of DNA nanotubes with controllable diameters and patterns using hierarchical DNA sub-tiles.
abstract: The design of DNA nanotubes is a promising and hot research branch in structural DNA nanotechnology, which is rapidly developing as a versatile method for achieving subtle nanometer scale materials and molecular diagnostic/curative devices. Multifarious methods have been proposed to achieve varied DNA nanotubes, such as using square tiles and single-stranded tiles, but it is still a challenge to develop a bottom-up assembly way to build DNA nanotubes with different diameters and patterns using certain universal DNA nanostructures. This work addresses the challenge by assembling three types of spatial DNA nanotubes with different diameters and patterns from the so-called "basic bricks", i.e., hierarchical DNA sub-tiles. A high processing rate and throughput synthesis of DNA nanotubes are observed and analyzed by atomic force microscopy. Experimental observations and data analysis suggests the stability and controllability of DNA nanotubes assembled by hierarchical DNA sub-tiles.
authors.affiliation: Key Laboratory of Image Information Processing and Intelligent Control, School of Automation, Huazhong University of Science and Technology, Wuhan 430074, Hubei, China.
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Shi
authors.forename: Xiaoxu
authors.initials: X
authors.lastname: Wu
authors.forename: Tao
authors.initials: T
authors.lastname: Song
authors.forename: Xin
authors.initials: X
authors.lastname: Li
mesh_terms: D004247:DNA; D018625:Microscopy, Atomic Force; D043942:Nanotubes; D009690:Nucleic Acid Conformation
chemical_list: D004247:DNA