title: Opportunities for Radiosensitization in the Stereotactic Body Radiation Therapy (SBRT) Era.
abstract: Stereotactic body radiation therapy (SBRT) utilizing a small number of high-dose radiation therapy fractions continues to expand in clinical application. Although many approaches have been proposed to radiosensitize tumors with conventional fractionation, how these radiosensitizers will translate to SBRT remains largely unknown. Here, we review our current understanding of how SBRT eradicates tumors, including the potential contributions of endothelial cell death and immune system activation. In addition, we identify several new opportunities for radiosensitization generated by the move toward high dose per fraction radiation therapy.
authors.affiliation: From the *Department of Radiation Oncology, Duke University, Durham; †Department of Internal Medicine, Moses H. Cone Memorial Hospital, Greensboro; and ‡Department of Pharmacology & Cancer Biology, Duke University, Durham, NC.
authors.forename: Everett J
authors.initials: EJ
authors.lastname: Moding
authors.forename: Yvonne M
authors.initials: YM
authors.lastname: Mowery
authors.forename: David G
authors.initials: DG
authors.lastname: Kirsch
mesh_terms: D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D007167:Immunotherapy / Q000379:methods*; D009369:Neoplasms / Q000276:immunology / Q000532:radiotherapy / Q000628:therapy*; D011836:Radiation Tolerance; D016634:Radiosurgery / Q000379:methods*