title: Dysfunctional gut microbiota and relative co-abundance network in infantile eczema.
abstract: BACKGROUND
  Infantile eczema is an immunological disease that is characterized by itchy and dry skin. Recent studies have suggested that gut microbiota (GM) plays a role in the development and progression of eczema. To further evaluate this potential link, we collected feces from 19 infants with eczema and 14 infants without eczema and analyzed the molecular discrepancies between the two groups using 16S rDNA analysis.
  
  
  RESULTS
  Bacteroidaceae and Deinococcaceae were significantly enriched in eczema infants, and Bacteroidaceae was potentially involved in autoimmune diseases by promoting the Th17 (T helper cell 17) secretion of IL-17 (interleukin-17). In the infants without eczema, the co-abundance network featured three core nodes: Clostridiaceae, Veillonellaceae, and Lactobacillaceae, all of which were lacking in the infants with eczema. Furthermore, our data suggested that Enterobacteriaceae was the core of the co-abundance network for the diseased subjects.
  
  
  CONCLUSIONS
  GM is closely connected to the human immune system, and the dysbiotic GM network plays a role in eczema. This study furthered our understanding of the dynamic GM network and its correlation to the occurrence of eczema.
authors.affiliation: Shenzhen Children's Hospital, No. 7019 Yitian Road, Shenzhen, 518026 China.
authors.forename: Heping
authors.initials: H
authors.lastname: Wang
authors.affiliation: WeHealthGene, No. 118 Wuhe Road, Shenzhen, 518129 China.
authors.forename: Yinhu
authors.initials: Y
authors.lastname: Li
authors.affiliation: WeHealthGene, No. 118 Wuhe Road, Shenzhen, 518129 China.
authors.forename: Xin
authors.initials: X
authors.lastname: Feng
authors.affiliation: Dongguan Maternal and Child Healthcare Hospital, No. 99 Zhenxing Road, Dongguan, 523000 China.
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Li
authors.affiliation: Shenzhen Children's Hospital, No. 7019 Yitian Road, Shenzhen, 518026 China.
authors.forename: Wenjian
authors.initials: W
authors.lastname: Wang
authors.affiliation: WeHealthGene, No. 118 Wuhe Road, Shenzhen, 518129 China.
authors.forename: Chuangzhao
authors.initials: C
authors.lastname: Qiu
authors.affiliation: Shenzhen Children's Hospital, No. 7019 Yitian Road, Shenzhen, 518026 China.
authors.forename: Jianqiang
authors.initials: J
authors.lastname: Xu
authors.affiliation: WeHealthGene, No. 118 Wuhe Road, Shenzhen, 518129 China.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Shenzhen Children's Hospital, No. 7019 Yitian Road, Shenzhen, 518026 China.
authors.forename: Zhichuan
authors.initials: Z
authors.lastname: Li
authors.affiliation: WeHealthGene, No. 118 Wuhe Road, Shenzhen, 518129 China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhou
authors.affiliation: Beijing Children's Hospital, No. 56 Nanlishi Road, Beijing, 100045 China.
authors.forename: Kaihu
authors.initials: K
authors.lastname: Yao
authors.affiliation: Shenzhen Children's Hospital, No. 7019 Yitian Road, Shenzhen, 518026 China.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Wang
authors.affiliation: Shenzhen Children's Hospital, No. 7019 Yitian Road, Shenzhen, 518026 China.
authors.forename: Yuzheng
authors.initials: Y
authors.lastname: Li
authors.affiliation: WeHealthGene, No. 118 Wuhe Road, Shenzhen, 518129 China.
authors.forename: Dongfang
authors.initials: D
authors.lastname: Li
authors.affiliation: WeHealthGene, No. 118 Wuhe Road, Shenzhen, 518129 China.
authors.forename: Wenkui
authors.initials: W
authors.lastname: Dai
authors.affiliation: Shenzhen Children's Hospital, No. 7019 Yitian Road, Shenzhen, 518026 China.
authors.forename: Yuejie
authors.initials: Y
authors.lastname: Zheng
keywords: Co-abundance; Gut microbiota; Infantile eczema; Network