title: Lewis Acid Catalyzed Cyclization of Propargylic Alcohols with 2-Vinylphenol.
abstract: An unprecedented Lewis acid catalyzed, protection-free, and high-efficiency synthesis of valuable 3,4-dihydro-2H-2,4-methanochromans via cycloaddition of propargylic alkynols with 2-vinylphenol is described. This cycloaddition protocol, which tolerates a wide variety of functional groups, provides practical, versatile, and atom-economical access to a new class of appealing bridged-ring products in satisfactory yields. Compared with the reported reaction conditions for bridged-ring skeletons synthesis, the present reaction conditions are neutral, mild, and without any additives.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, China.
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Han
authors.affiliation: Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science Technology Normal University , Nanchang 330013, China.
authors.forename: Xian-Rong
authors.initials: XR
authors.lastname: Song
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, China.
authors.forename: Yi-Feng
authors.initials: YF
authors.lastname: Qiu
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, China.
authors.forename: Xue-Song
authors.initials: XS
authors.lastname: Li
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, China.
authors.forename: Heng-Rui
authors.initials: HR
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, China.
authors.forename: Xin-Yu
authors.initials: XY
authors.lastname: Zhu
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, China.
authors.forename: Xue-Yuan
authors.initials: XY
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, China.|State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences , Lanzhou 730000, China.
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Liang