title: [Early endocrine complications in childhood cancer survivors].
abstract: OBJECTIVE
  The treatment of childhood cancers has increased survival rates, but also the risk of sequelae, such as endocrine complications. The objective of this study is to evaluate the endocrine disorders in survivors of childhood malignant tumors within the first years after treatment and analyze the variables related to their appearance.
  
  
  METHODS
  A retrospective medical record review of patients referred to pediatric endocrinology after treatment of malignancy. Outcome measures were frequency and types of endocrine dysfunction and new-onset obesity. Clinical and laboratory evaluations were performed every 6 months. Statistics tests were: chi square and multiple logistic regression.
  
  
  RESULTS
  Fifty five patients (26 women) were included with an age at diagnosis of tumour (mean±standard deviation) 6.0±4.4 years and followed up for 6.8±3.6 years. Thirty endocrine disorders were diagnosed in 26 patients (47.3%), 17 women (P=.01). Eleven adolescents had primary hypogonadism (26.2% to 0.6±0.5 years of follow-up) in relation to local irradiation (adjusted odds ratio [OR] 3.99, P=.005). Eleven patients had a pituitary disorder (20.0%) 5.2±2.4 years after diagnosis in relation to brain irradiation (OR 1.54, P=.039). Six children (10.9%) had primary hypothyroidism from 3.2±1.0 years of follow-up. Two children developed obesity.
  
  
  CONCLUSIONS
  Endocrine disorders are frequently seen within the first years after diagnosis of a childhood cancer, so hormonal evaluation should start early and be repeated periodically.
authors.affiliation: Unidad de Pediatría, Hospital Virgen del Rocío, Sevilla, España.
authors.forename: Cristina
authors.initials: C
authors.lastname: Sánchez González
authors.affiliation: Unidad de Pediatría, Hospital Virgen del Rocío, Sevilla, España.
authors.forename: Mónica
authors.initials: M
authors.lastname: Andrades Toledo
authors.affiliation: Unidad de Pediatría, Hospital Virgen del Rocío, Sevilla, España.
authors.forename: Álvaro
authors.initials: Á
authors.lastname: Cárdeno Morales
authors.affiliation: Unidad de Oncología Pediátrica, Hospital Virgen del Rocío, Sevilla, España.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Gutiérrez Carrasco
authors.affiliation: Unidad de Oncología Pediátrica, Hospital Virgen del Rocío, Sevilla, España.
authors.forename: Gema Lucía
authors.initials: GL
authors.lastname: Ramírez Villar
authors.affiliation: Unidad de Hematología, Hospital Virgen del Rocío, Sevilla, España.
authors.forename: José María
authors.initials: JM
authors.lastname: Pérez Hurtado
authors.affiliation: Unidad de Pediatría, Hospital Virgen del Rocío, Sevilla, España. Electronic address: ejgg67@gmail.com.
authors.forename: Emilio
authors.initials: E
authors.lastname: García García
mesh_terms: D000293:Adolescent; D000073116:Cancer Survivors; D002648:Child; D002675:Child, Preschool; D004700:Endocrine System Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D009369:Neoplasms / Q000150:complications* / Q000628:therapy; D012189:Retrospective Studies; D012307:Risk Factors
keywords: Cancer; Child; Childhood cancer survivor; Cáncer; Efectos tardíos; Endocrine system disease; Enfermedad del sistema endocrino; Late effects; Niño; Niños supervivientes de cáncer