title: Efficacy and toxicity of plasmonic photothermal therapy (PPTT) using gold nanorods (GNRs) against mammary tumors in dogs and cats.
abstract: Plasmonic photothermal therapy (PPTT) was introduced as a promising treatment of cancer. This work was conducted to evaluate the cytotoxic effect of intratumoral (IT) injection of 75μg gold nanorods (GNRs)/kg of body weight followed by direct exposure to 2 w/cm2near infra-red laser light for 10min on ablation of mammary tumor in 10 dogs and 6 cats. Complete blood count (CBC), liver and kidney function were checked before the start of treatment and one month after injection of GNRs. Results showed that 62.5% (10/16), 25% (4/16) and 12.5% (2/16) of treated animals showed complete remission, partial remission and no response, respectively. Tumor was relapsed in 4 cases of initially responding animals (25%). Overall survival rate was extended to 315.5±20.5days. GNRs have no toxic effect on blood profile, liver or kidney functions. In conclusion, GNRs can be safely used for treatment of mammary tumors in dogs and cats.
authors.affiliation: Animal Reproduction Department, Veterinary Research Division, National Research Center (NRC), Egypt. Electronic address: assabdoon@yahoo.com.
authors.forename: Ahmed S
authors.initials: AS
authors.lastname: Abdoon
authors.affiliation: Spectroscopy Department, Physics Division, NRC, Egypt.
authors.forename: Emad A
authors.initials: EA
authors.lastname: Al-Ashkar
authors.affiliation: Animal Reproduction Department, Veterinary Research Division, National Research Center (NRC), Egypt.
authors.forename: Omaima M
authors.initials: OM
authors.lastname: Kandil
authors.affiliation: Environmental Research Division, NRC, Egypt.
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Shaban
authors.affiliation: National Cancer Institute, Cairo University, Egypt.
authors.forename: Hussein M
authors.initials: HM
authors.lastname: Khaled
authors.affiliation: Laser Dynamics Laboratory, Chemistry and Biochemistry Department, Georgia Institute of Technology, USA.
authors.forename: Mostafa A
authors.initials: MA
authors.lastname: El Sayed
authors.affiliation: Pathology Department, Medical Research Division, NRC, Egypt.
authors.forename: Marwa M
authors.initials: MM
authors.lastname: El Shaer
authors.affiliation: Biological Anthropology Department, Medical Research Division, NRC, Egypt.
authors.forename: Asharaf H
authors.initials: AH
authors.lastname: Shaalan
authors.affiliation: Spectroscopy Department, Physics Division, NRC, Egypt.
authors.forename: Wael H
authors.initials: WH
authors.lastname: Eisa
authors.affiliation: Pathology Department, Medical Research Division, NRC, Egypt.
authors.forename: Amina A Gamal
authors.initials: AA
authors.lastname: Eldin
authors.affiliation: Animal Reproduction Department, Veterinary Research Division, National Research Center (NRC), Egypt.
authors.forename: Hany A
authors.initials: HA
authors.lastname: Hussein
authors.affiliation: Pet Lovers Veterinary Clinic, Cairo, Egypt.
authors.forename: Mohammad R
authors.initials: MR
authors.lastname: El Ashkar
authors.affiliation: Laser Dynamics Laboratory, Chemistry and Biochemistry Department, Georgia Institute of Technology, USA.
authors.forename: Moustafa R
authors.initials: MR
authors.lastname: Ali
authors.affiliation: Spectroscopy Department, Physics Division, NRC, Egypt.
authors.forename: Ali A
authors.initials: AA
authors.lastname: Shabaka
mesh_terms: D000818:Animals; D002415:Cats; D004285:Dogs; D006046:Gold / Q000008:administration & dosage*; D006979:Hyperthermia, Induced; D015674:Mammary Neoplasms, Animal / Q000188:drug therapy*; D043942:Nanotubes; D010789:Phototherapy
chemical_list: D006046:Gold
keywords: Cytotoxicity; Dogs and cats; Gold nanorods; Mammary tumors; Near infra-red light; Toxicity