title: [Proton pump inhibitors: not as safe as they seem].
abstract: - Proton pump inhibitors (PPIs) are among the most widely used drugs worldwide. However, some patients use them without a good indication.- Although PPIs are generally safe, there is an increasing number of signals of potentially serious side effects.- This article gives an overview of the incidence and prevalence of the following side effects: gastroenteritis, respiratory tract infections, hypomagnesaemia, renal function disorders, vitamin B12 and iron deficiency, dementia, osteoporosis and fractures.- It is important to prescribe a PPI only when there is a good indication for use. Patients with chronic PPI use should be checked periodically to see whether there is still an indication.- If any of the listed side effects should occur, it is advisable to consider PPI as a possible cause.
authors.affiliation: Canisius-Wilhelmina Ziekenhuis, Nijmegen.
authors.forename: N
authors.initials: N
authors.lastname: van Herwaarden
authors.forename: J M
authors.initials: JM
authors.lastname: Bos
authors.forename: B
authors.initials: B
authors.lastname: Veldman
authors.forename: C
authors.initials: C
authors.lastname: Kramers
mesh_terms: D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004334:Drug Administration Schedule; D064420:Drug-Related Side Effects and Adverse Reactions / Q000209:etiology*; D050723:Fractures, Bone / Q000139:chemically induced; D005759:Gastroenteritis / Q000139:chemically induced; D006801:Humans; D054328:Proton Pump Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D018570:Risk Assessment; D012307:Risk Factors; D014806:Vitamin B 12 Deficiency / Q000139:chemically induced
chemical_list: D000897:Anti-Ulcer Agents; D054328:Proton Pump Inhibitors