title: Advances in mechanistic understanding of release rate control mechanisms of extended-release hydrophilic matrix tablets.
abstract: Approaches to characterizing and developing understanding around the mechanisms that control the release of drugs from hydrophilic matrix tablets are reviewed. While historical context is provided and direct physical characterization methods are described, recent advances including the role of percolation thresholds, the application on magnetic resonance and other spectroscopic imaging techniques are considered. The influence of polymer and dosage form characteristics are reviewed. The utility of mathematical modeling is described. Finally, how all the information derived from applying the developed mechanistic understanding from all of these tools can be brought together to develop a robust and reliable hydrophilic matrix extended-release tablet formulation is proposed.
authors.affiliation: Drug Product Science & Technology, Bristol-Myers Squibb, Merseyside, UK.|Department of Pharmacy, University of Huddersfield, Queensgate, Huddersfield, HD1 3DH, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: Timmins
authors.affiliation: Drug Product Science & Technology, Bristol-Myers Squibb, NJ, USA.
authors.forename: Divyakant
authors.initials: D
authors.lastname: Desai
authors.affiliation: Drug Product Science & Technology, Bristol-Myers Squibb, NJ, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.affiliation: Drug Product Science & Technology, Bristol-Myers Squibb, Merseyside, UK.
authors.forename: Patrick
authors.initials: P
authors.lastname: Wray
authors.affiliation: Drug Product Science & Technology, Bristol-Myers Squibb, Merseyside, UK.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Brown
authors.affiliation: Drug Product Science & Technology, Bristol-Myers Squibb, Merseyside, UK.
authors.forename: Sarah
authors.initials: S
authors.lastname: Hanley
mesh_terms: D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D057927:Hydrophobic and Hydrophilic Interactions; D015233:Models, Statistical; D012995:Solubility; D013607:Tablets
chemical_list: D003692:Delayed-Action Preparations; D013607:Tablets
keywords: extended-release; hydrophilic matrix tablets; release-rate mechanisms