title: [THE PERSPECTIVES OF STUDYING OF POLYMORPHISM OF GENES OF GAMMA-INTERFERON UNDER CHRONIC BRUCELLOSIS].
abstract: The brucellosis is an actual zoonotic disease in many countries, Russia included. The complexity of individual prognosis of disease and choice of tactics of maintenance of patients is explained by heterogeneity of clinical manifestations of brucellosis and different rate of progression of organs pathology. Despite of low mortality, this pathology quite often results in disability of patient. The frequent transition of acute process into chronic one (40-60%), probability of development of primary chronic brucellosis determines interest of researchers to issues of immunopathogenesis of this disease. The article presents review of achievements in studies of polymorphism of genes of gamma-interferon in the given area.
authors.forename: A Kh
authors.initials: AKh
authors.lastname: Nurpeisova
authors.forename: A N
authors.initials: AN
authors.lastname: Kolomeietz
mesh_terms: D000208:Acute Disease; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002002:Brucella / Q000187:drug effects / Q000472:pathogenicity / Q000502:physiology; D002006:Brucellosis / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology / Q000382:microbiology; D002908:Chronic Disease; D015870:Gene Expression; D020022:Genetic Predisposition to Disease; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics* / Q000276:immunology; D008168:Lung / Q000187:drug effects / Q000276:immunology / Q000382:microbiology; D008171:Lung Diseases / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology / Q000382:microbiology; D011110:Polymorphism, Genetic
chemical_list: D000900:Anti-Bacterial Agents; D007371:Interferon-gamma