title: [Eccrine angiomatous hamartoma: a clinicalopathologic analysis of 4 cases].
abstract: OBJECTIVE
  To investigate the clinical and histopathologic features, diagnosis and differential diagnosis of eccrine angiomatous hamartoma(EAH).
  
  
  METHODS
  Four cases of eccrine angiomatous hamartoma were studied by light microscopy and immunohistochemical staining along with review of the literature.
  
  
  RESULTS
  There were 3 male and 1 female patients at diagnosis in age of 4 months, 3.5 years, 5.5 years and 14.0 years, respectively. Tumor sites included the left little finger (1 case), right index finger (1 case), lower back (1 case) and knee (1 case). Clinically, most cases presented as a solitary, flesh or reddish papule, plaque or nodule with size of 0.4-6.0 cm in diameter. The skin lesions in 3 cases enlarged commensurate with the growth of the patients, and local hyperhidrosis in one case. Histologically, EAH was characterized by proliferation of well-differentiated eccrine secretory and ductal elements closely associated with thin-walled angiomatous channels in the middle or deep dermis and subcutaneous tissue. By immunohistochemistry, the vascular components were positive for CD31, CD34 and factor Ⅷ related antigen while the eccrine glands were positive for S-100 protein, CEA, EMA, CAM5.2 and GCDFP15. Local surgical resection was performed in 4 cases and follow-up data (0.5 to 4.5 years) showed no recurrence.
  
  
  CONCLUSIONS
  EAH is a rare, benign cutaneous hamartoma. Combination of clinical manifestations, histological changes and immunohistochemical findings is useful for the diagnosis and differential diagnosis.
authors.affiliation: Department of Pathology, Zhuhai People's Hospital, Zhuhai 519000, China.
authors.forename: X H
authors.initials: XH
authors.lastname: Guo
authors.forename: G Y
authors.initials: GY
authors.lastname: Yang
authors.forename: C B
authors.initials: CB
authors.lastname: Li
authors.forename: L J
authors.initials: LJ
authors.lastname: Wang
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.forename: X J
authors.initials: XJ
authors.lastname: Yuan
mesh_terms: D003937:Diagnosis, Differential; D004439:Eccrine Glands / Q000737:chemistry / Q000473:pathology*; D005260:Female; D006222:Hamartoma / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D012871:Skin Diseases / Q000473:pathology; D013543:Sweat Gland Diseases / Q000473:pathology*