title: An Intractable Case of Prototheca Keratitis and Chronic Endophthalmitis in Stevens-Johnson Syndrome With Boston Type 1 Keratoprosthesis.
abstract: OBJECTIVE
  To report a case of recalcitrant Prototheca spp. keratitis and endophthalmitis in a patient with Stevens-Johnson syndrome (SJS) and Boston type 1 keratoprosthesis (B1 KPro).
  
  
  METHODS
  Case report.
  
  
  RESULTS
  A 67-year-old female with a history of SJS with chronic severe ocular surface disease in her monocular left eye underwent placement of a B1 KPro. Her course was subsequently complicated by persistent Prototheca spp. keratitis and endophthalmitis requiring ongoing treatment with triazole and polyene antifungal agents and multiple surgical revisions of her keratoprosthesis.
  
  
  CONCLUSIONS
  Protothecosis is an algal infection that is rarely pathologic in humans, but when present can be difficult to manage. We present the second known case of persistent chronic Prototheca spp. keratitis and endophthalmitis in a patient with long-standing SJS and B1 KPro.
authors.affiliation: *Gavin Herbert Eye Institute, University of California Irvine, Irvine, CA; †Pathology Department, UCI Medical Center, Orange, CA; Departments of ‡Medicine; §Pediatrics; and ¶Microbiology and Immunology, New York Presbyterian Hospital, Weill Cornell Medicine of Cornell University, New York, NY.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Ng
authors.forename: Don
authors.initials: D
authors.lastname: Minckler
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Walsh
authors.forename: Marjan
authors.initials: M
authors.lastname: Farid
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use; D001187:Artificial Organs; D001705:Bioprosthesis; D003315:Cornea; D003320:Corneal Ulcer / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D004359:Drug Therapy, Combination; D009877:Endophthalmitis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D015821:Eye Infections, Fungal / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D005260:Female; D006801:Humans; D019736:Prostheses and Implants; D019919:Prosthesis Implantation; D016459:Prosthesis-Related Infections / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D011525:Prototheca / Q000302:isolation & purification*; D012086:Reoperation; D012189:Retrospective Studies; D013262:Stevens-Johnson Syndrome / Q000601:surgery*; D014822:Vitreous Body / Q000382:microbiology
chemical_list: D000935:Antifungal Agents