title: The anti-oncogenic influence of ellagic acid on colon cancer cells in leptin-enriched microenvironment.
abstract: Ellagic acid (EA) has been proposed as a promising candidate for therapeutic use in colon cancer. Investigation of the effectiveness of EA in a leptin-enriched model might have been given a little interest. Here in, we investigated the anti-tumor effect of EA in the presence of leptin to reflect on therapeutic use of EA in obesity-linked colon cancer. Proven effective in leptin-enriched microenvironment, EA inhibited cell proliferation of HCT-116 and CaCo-2 cell lines, modulated cell cycle, translocated Bax to the mitochondrial fraction of cells, activated caspase-8, and reduced PCNA expression. The current study findings cast a beam of light on the potential therapeutic use of EA in obesity-related colon carcinogenesis.
authors.affiliation: Department of Applied Medical Chemistry, Medical Research Institute, University of Alexandria, 165, Horreya Avenue, Hadara, Alexandria, 21561, Egypt.
authors.forename: Amany I
authors.initials: AI
authors.lastname: Yousef
authors.affiliation: Department of Applied Medical Chemistry, Medical Research Institute, University of Alexandria, 165, Horreya Avenue, Hadara, Alexandria, 21561, Egypt. oselmasry@uod.edu.sa.
authors.forename: Omar S
authors.initials: OS
authors.lastname: El-Masry
authors.affiliation: Department of Applied Medical Chemistry, Medical Research Institute, University of Alexandria, 165, Horreya Avenue, Hadara, Alexandria, 21561, Egypt.
authors.forename: Eman H
authors.initials: EH
authors.lastname: Yassin
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D015415:Biomarkers; D018938:Caco-2 Cells; D053181:Caspase 8 / Q000378:metabolism; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003110:Colonic Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D004610:Ellagic Acid / Q000494:pharmacology*; D006801:Humans; D020738:Leptin / Q000378:metabolism* / Q000494:pharmacology; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D059016:Tumor Microenvironment / Q000187:drug effects* / Q000235:genetics
chemical_list: D000970:Antineoplastic Agents; D015415:Biomarkers; D020738:Leptin; D018809:Proliferating Cell Nuclear Antigen; D004610:Ellagic Acid; D053181:Caspase 8
keywords: Cellular genetics; Colon; Ellagic acid; Leptin