title: [DYNAMICS OF BACTERIOLOGICAL AND PLANIMETRIC INDICES OF THE WOUND UNDER THE ACTION OF THE SILVER NANOPARTICLES, STABILIZED BY MEXIDOL AND POLYVINYLPYRROLIDONE].
abstract: Changes in bacteriological indices through the square of the wound of chemical origin under local impact of the silver nanoparticles (NP), stabilized by 2-ethyl-6-methyl-3-hydroxypyridine succinate (mexidol) and polyvinylpyrrolidone were studied. The wounds of submandibular region were simulated in white rats, using injection of 10% solution of calcium chloride with further opening of necrotic foci and open management of the wound. Beginning from the fifth day, every day the wound was irrigated with liquid, which have contented the stabilized NP of the silver, 0.05% water solution of chlorhexidine or isotonic solution of the the sodium chloride (control). There was established, that the silver NP impact antiseptically and regenerative while the wound treatment, and reduce during 10 days microbial contamination of exudate in 24 times, the wound square--in three times in comparison with original indices. These changes were identical to those while application of chlorhexidine.
authors.forename: V I
authors.initials: VI
authors.lastname: Lyakhovskyi
authors.forename: G A
authors.initials: GA
authors.lastname: Lobahn
authors.forename: O V
authors.initials: OV
authors.lastname: Gancho
authors.forename: O M
authors.initials: OM
authors.lastname: Vazhnycha
authors.forename: S V
authors.initials: SV
authors.lastname: Kolomiyets
authors.forename: V Kh O
authors.initials: VKh
authors.lastname: Jaber
mesh_terms: D000818:Animals; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D058491:Bacterial Load; D002122:Calcium Chloride; D002710:Chlorhexidine / Q000494:pharmacology; D008297:Male; D008334:Mandible / Q000187:drug effects / Q000382:microbiology / Q000473:pathology; D053768:Metal Nanoparticles / Q000627:therapeutic use*; D010847:Picolines / Q000737:chemistry; D011205:Povidone / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012834:Silver / Q000494:pharmacology*; D018461:Soft Tissue Infections / Q000139:chemically induced / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects; D014946:Wound Infection / Q000139:chemically induced / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology
chemical_list: D000891:Anti-Infective Agents, Local; D010847:Picolines; C070020:emoxypine succinate; D012834:Silver; D011205:Povidone; D002122:Calcium Chloride; D002710:Chlorhexidine