title: Sustained static stress-induced chondrocyte apoptosis in the rat cervical vertebral growth plate and its signal transduction mechanisms.
abstract: Apoptosis of the vertebral growth plate chondrocytes plays an important role in the pathogenesis of intervertebral disk degeneration. In this paper, we have successfully established an experimental model induced by static stress and provided a useful method to study the mechanisms of chondrocyte apoptosis. A sustained static load of ≥0.2 MPa over at least 12 h was observed to induce chondrocyte apoptosis, up-regulation of bax and caspase-3 expression, and down-regulation of bcl-2 expression.
authors.affiliation: Department of Emergency, Taizhou People's Hospital, 210 Yingchun Road, Taizhou, Jiangsu Province, 225300, People's Republic of China.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu Province, 210029, People's Republic of China.
authors.forename: Tiansheng
authors.initials: T
authors.lastname: Zheng
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu Province, 210029, People's Republic of China.
authors.forename: Min
authors.initials: M
authors.lastname: Zong
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu Province, 210029, People's Republic of China.
authors.forename: Dechao
authors.initials: D
authors.lastname: Kong
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu Province, 210029, People's Republic of China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu Province, 210029, People's Republic of China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Xue
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu Province, 210029, People's Republic of China.
authors.forename: Peng
authors.initials: P
authors.lastname: Fu
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu Province, 210029, People's Republic of China. fjh4508@163.com.
authors.forename: Jiahu
authors.initials: J
authors.lastname: Fang
keywords: Cell apoptosis; Growth plate; Stress