title: THE EFFECT OF PHOTOPIGMENT BLEACHING ON FUNDUS AUTOFLUORESCENCE IN ACUTE CENTRAL SEROUS CHORIORETINOPATHY.
abstract: OBJECTIVE
  To evaluate the effect of photobleaching on fundus autofluorescence (FAF) images in acute central serous chorioretinopathy.
  
  
  METHODS
  We obtained prephotobleaching and postphotobleaching images using an Optomap 200Tx, and photobleaching was induced with a Heidelberg Retina Angiograph 2. Degrees of photobleaching were assessed as grayscale values in Optomap images. Concordances among the three kinds of images were analyzed. Hyper-AF lesions in prephotobleaching images were classified as Type 1 (changed to normal-AF after photobleaching) and Type 2 (unchanged after photobleaching). The FAF composite patterns of central serous chorioretinopathy lesions were classified as diffuse or mottled. Initial and final best-corrected visual acuity, central retinal thickness, and disease duration were compared according to fovea FAF type.
  
  
  RESULTS
  Forty-one eyes of 41 patients were analyzed. The lesion brightness of postphotobleaching Optomap FAF showed greater concordance with Heidelberg Retina Angiograph 2 FAF (94.74%) than the prephotobleaching Optomap FAF (80.49%). Eyes with Type 1 fovea had greater initial and final best-corrected visual acuity (20/23 vs. 20/41, 20/21 vs. 20/32, P < 0.0001, P = 0.001, respectively) and shorter disease duration (19.68 ± 12.98 vs. 51.55 ± 44.98 days, P = 0.043) than those with Type 2 fovea. However, eyes with diffuse Type 2 fovea had only lower initial and final best-corrected visual acuity (20/23 vs. 20/45, 20/21 vs. 20/36, P < 0.0001, P < 0.0001, respectively) than those with Type 1 fovea.
  
  
  CONCLUSIONS
  Understanding the photobleaching effect is necessary for the accurate interpretation of FAF images. Furthermore, comparing prephotobleaching and postphotobleaching FAF images may be helpful for estimation of lesion status in central serous chorioretinopathy.
authors.affiliation: Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.
authors.forename: Kwang-Eon
authors.initials: KE
authors.lastname: Choi
authors.forename: Cheolmin
authors.initials: C
authors.lastname: Yun
authors.forename: Young-Ho
authors.initials: YH
authors.lastname: Kim
authors.forename: Seong-Woo
authors.initials: SW
authors.lastname: Kim
authors.forename: Jaeryung
authors.initials: J
authors.lastname: Oh
authors.forename: Kuhl
authors.initials: K
authors.lastname: Huh
mesh_terms: D000208:Acute Disease; D000328:Adult; D056833:Central Serous Chorioretinopathy / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D008027:Light; D008297:Male; D008875:Middle Aged; D061848:Optical Imaging; D018462:Photobiology; D012160:Retina / Q000473:pathology*; D012168:Retinal Pigments / Q000528:radiation effects*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology
chemical_list: D012168:Retinal Pigments