title: Association between Renal Function and Open-Angle Glaucoma: The Korea National Health and Nutrition Examination Survey 2010-2011.
abstract: To investigate the relationship between renal function and primary open-angle glaucoma (POAG) in a South Korean population.
  
  
  
  A population-based, cross-sectional survey using a multistage, stratified, probability-clustered sampling method from the Korean National Health and Nutrition Examination Survey (KNHANES).
  
  
  
  A total of 5971 participants at least 40 years of age were selected from the KNHANES between 2010 and 2011.
  
  
  
  A standardized protocol was used to interview every participant and perform comprehensive ophthalmic examinations. Glaucoma was diagnosed according to criteria from the International Society of Geographical and Epidemiological Ophthalmology. The estimated glomerular filtration rate (eGFR) was calculated from serum creatinine concentrations using the Cockcroft-Gault formula, as follows: eGFR = (140 - age) × mass (kg) × (0.85 for female subjects)/(72 × serum creatinine (mg/dl). The presence of proteinuria also was assessed. Subjects were stratified by eGFR into the following groups: ≥90, 60-90, 45-59, and <45 ml/min/1.73 m(2).
  
  
  
  Renal function and POAG.
  
  
  
  The overall prevalence of POAG was 5.5%. The prevalence of low eGFR (<60 ml/min/1.73 m(2)) was 9.5%, and the prevalence of eGFR <45 ml/min/1.73 m(2) was 2.0%. Multiple linear regression models were adjusted for age, sex, and other confounding factors (high-density lipoprotein level, blood glucose concentration, blood pressure, and intraocular pressure). These models revealed a positive correlation between the presence of POAG and low eGFR (odds ratio [OR], 2.88; 95% confidence interval [CI], 1.44-5.76). No association was found between proteinuria and POAG (adjusted for age, sex, and other confounding factors; OR, 0.96; 95% CI, 0.29-3.17).
  
  
  
  This population-based study of South Korean adults showed that low eGFR levels are independently associated with POAG.
authors.affiliation: Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Seong Hee
authors.initials: SH
authors.lastname: Shim
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Ki-Chul
authors.initials: KC
authors.lastname: Sung
authors.affiliation: Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. Electronic address: joonmo1.kim@samsung.com.
authors.forename: Joon Mo
authors.initials: JM
authors.lastname: Kim
authors.affiliation: Department of Biostatistics, Kangbuk Samsung Hospital, Seoul, Korea.
authors.forename: Mi Yeon
authors.initials: MY
authors.lastname: Lee
authors.affiliation: Department of Neurosurgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Yu Sam
authors.initials: YS
authors.lastname: Won
authors.affiliation: Department of Ophthalmology, Inje University Sanggye Paik Hospital, Seoul, Korea.
authors.forename: Jung Hoon
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.
authors.forename: Ki Ho
authors.initials: KH
authors.lastname: Park
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D003404:Creatinine / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D005902:Glaucoma, Open-Angle / Q000453:epidemiology* / Q000209:etiology; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011507:Proteinuria / Q000453:epidemiology; D012044:Regression Analysis; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000150:complications / Q000453:epidemiology*; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors; D017678:Sex Distribution; D058609:Visual Field Tests
chemical_list: D003404:Creatinine