title: Understanding Age-Related Changes in Skeletal Muscle Metabolism: Differences Between Females and Males.
abstract: Skeletal muscle is the largest metabolic organ system in the human body. As such, metabolic dysfunction occurring in skeletal muscle impacts whole-body nutrient homeostasis. Macronutrient metabolism changes within the skeletal muscle with aging, and these changes are associated in part with age-related skeletal muscle remodeling. Moreover, age-related changes in skeletal muscle metabolism are affected differentially between males and females and are likely driven by changes in sex hormones. Intrinsic and extrinsic factors impact observed age-related changes and sex-related differences in skeletal muscle metabolism. Despite some support for sex-specific differences in skeletal muscle metabolism with aging, more research is necessary to identify underlying differences in mechanisms. Understanding sex-specific aging skeletal muscle will assist with the development of therapies to attenuate adverse metabolic and functional outcomes.
authors.affiliation: Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853; email: aet74@cornell.edu.
authors.forename: Brandon J F
authors.initials: BJ
authors.lastname: Gheller
authors.affiliation: Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853; email: aet74@cornell.edu.
authors.forename: Emily S
authors.initials: ES
authors.lastname: Riddle
authors.affiliation: Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853; email: aet74@cornell.edu.
authors.forename: Melinda R
authors.initials: MR
authors.lastname: Lem
authors.affiliation: Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853; email: aet74@cornell.edu.
authors.forename: Anna E
authors.initials: AE
authors.lastname: Thalacker-Mercer
mesh_terms: D000375:Aging; D000818:Animals; D001343:Autophagy; D000072001:Diet, Healthy; D004734:Energy Metabolism; D019317:Evidence-Based Medicine; D015444:Exercise; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D024510:Muscle Development; D018482:Muscle, Skeletal / Q000254:growth & development / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D009220:Myositis / Q000276:immunology / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D009765:Obesity / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control / Q000628:therapy; D055948:Sarcopenia / Q000378:metabolism* / Q000473:pathology / Q000517:prevention & control / Q000628:therapy; D012727:Sex Characteristics
keywords: aging; macronutrient; metabolism; sex; skeletal muscle