title: Histiocytic Sarcoma Associated with Coombs Negative Acute Hemolytic Anemia: A Rare Presentation.
abstract: Histiocytic sarcoma (HS) rarely involves extranodal sites, such as the spleen. We report a unique pediatric case of massive splenomegaly and refractory Coombs negative hemolytic anemia (CNHA) secondary to HS. The CNHA resolved completely after an emergent splenectomy. Next generation sequencing (NGS) revealed novel ASXL1, PTPN11, KIT, and TP53 mutations, unmasking a clonal heterogeneity within the same neoplasm.
authors.affiliation: Department of Pediatrics, Section of Pediatric Hematology and Oncology, Riley Hospital for Children at Indiana University Health, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
authors.forename: Sandeep
authors.identifier: 0000-0001-5778-3200
authors.initials: S
authors.lastname: Batra
authors.affiliation: Department of Pediatrics, Section of Pediatric Hematology and Oncology, Riley Hospital for Children at Indiana University Health, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Martin
authors.affiliation: Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Nassiri
authors.affiliation: Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
authors.forename: Amna
authors.initials: A
authors.lastname: Qureshi
authors.affiliation: Department of Surgery, Section of Pediatric Surgery, Riley Hospital for Children at Indiana University Health, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
authors.forename: Troy A
authors.initials: TA
authors.lastname: Markel