title: Endometrial cancer and antidepressants: A nationwide population-based study.
abstract: To our knowledge, the association between antidepressant exposure and endometrial cancer has not been previously explored. Herein, we aim to investigate the association between antidepressant prescription, including novel antidepressants, and the risk for endometrial cancer in a population-based study.Data for the analysis were derived from National Health Insurance Research Database. We identified 8392 cases with a diagnosis of endometrial cancer and 82,432 matched controls. A conditional logistic regression model was used, with adjusting for potentially confounding variables (e.g., comorbid psychiatric diseases, comorbid physical diseases, and other medications). Risk for endometrial cancer in the population-based study sample was categorized by, and assessed as a function of, antidepressant prescription and cumulative dosage.We report no association between endometrial cancer incidence and antidepressant prescription, including those prescribed either selective serotonin reuptake inhibitors (adjusted odds ratio [OR] = 0.98; 95% confidence interval [CI], 0.84-1.15) or serotonin norepinephrine reuptake inhibitors (adjusted OR = 1.14; 95% CI, 0.76-1.71). We also did not identify an association between higher cumulative doses of antidepressant prescription and endometrial cancer.There was no association between antidepressant prescription and endometrial cancer.
authors.affiliation: Department of Child Psychiatry, Linkou Chang Gung Memorial Hospital Department of Psychiatry, Chang Gung University, Taoyuan Department of Psychiatry, Cathay General Hospital, Taipei Department of Speech, Language Pathology and Audiology, Chung Shan Medical University, Taichung, Taiwan Mood Disorders Psychopharmacology Unit, University Health Network Department of Psychiatry, University of Toronto, Toronto, ON, Canada Department of Psychiatry, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan.
authors.forename: Chiao-Fan
authors.initials: CF
authors.lastname: Lin
authors.forename: Hsiang-Lin
authors.initials: HL
authors.lastname: Chan
authors.forename: Yi-Hsuan
authors.initials: YH
authors.lastname: Hsieh
authors.forename: Hsin-Yi
authors.initials: HY
authors.lastname: Liang
authors.forename: Wei-Che
authors.initials: WC
authors.lastname: Chiu
authors.forename: Kuo-You
authors.initials: KY
authors.lastname: Huang
authors.forename: Yena
authors.initials: Y
authors.lastname: Lee
authors.forename: Roger S
authors.initials: RS
authors.lastname: McIntyre
authors.forename: Vincent Chin-Hung
authors.initials: VC
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000928:Antidepressive Agents / Q000627:therapeutic use*; D016022:Case-Control Studies; D015986:Confounding Factors, Epidemiologic; D016889:Endometrial Neoplasms / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology
chemical_list: D000928:Antidepressive Agents