title: The Antimicrobial Peptides P-113Du and P-113Tri Function against Candida albicans.
abstract: Two antimicrobial P-113 peptide derivatives, P-113Du and P-113Tri, were investigated in this study. Notably, P-113Du and P-113Tri contained significant fractions of α-helix conformation and were less sensitive to high salt and low pH than P-113. Moreover, compared to P-113, these peptides exhibited increased antifungal activity against planktonic cells, biofilm cells, and clinical isolates of Candida albicans and non-albicans Candida spp. These results suggest that P-113Du and P-113Tri are promising candidates for development as novel antifungal agents.
authors.affiliation: Institute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu, Taiwan.
authors.forename: Guan-Yu
authors.initials: GY
authors.lastname: Lin
authors.affiliation: Institute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu, Taiwan.
authors.forename: Hsueh-Fen
authors.initials: HF
authors.lastname: Chen
authors.affiliation: Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan.
authors.forename: Yao-Peng
authors.initials: YP
authors.lastname: Xue
authors.affiliation: Institute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu, Taiwan.
authors.forename: Ying-Chieh
authors.initials: YC
authors.lastname: Yeh
authors.affiliation: Institute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu, Taiwan.
authors.forename: Chia-Lu
authors.initials: CL
authors.lastname: Chen
authors.affiliation: General Biologicals Corporation, Hsinchu, Taiwan.
authors.forename: Ming-Sun
authors.initials: MS
authors.lastname: Liu
authors.affiliation: General Biologicals Corporation, Hsinchu, Taiwan wenchi.cheng@gbc.com.tw cylan@life.nthu.edu.tw.
authors.forename: Wen-Chi
authors.initials: WC
authors.lastname: Cheng
authors.affiliation: Institute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu, Taiwan Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan wenchi.cheng@gbc.com.tw cylan@life.nthu.edu.tw.
authors.forename: Chung-Yu
authors.initials: CY
authors.lastname: Lan
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology; D018441:Biofilms / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D054808:Histatins / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008826:Microbial Sensitivity Tests; D010933:Plankton / Q000382:microbiology; D011487:Protein Conformation
chemical_list: D000935:Antifungal Agents; D054808:Histatins; C488466:P-113D; C000621195:P-113Tri; D001205:Ascorbic Acid