title: Quantification of Transfusion Recipients at Risk of Receiving Hepatitis B Virus-Contaminated Blood Components: A Korean Study.
abstract: Although there are lots of studies about the risk for the hepatitis B virus infection such as the residual risk for donated blood, there is no research on the risk of HBV infection, from the viewpoint of recipients in Korea. Using the data about HBsAg status of donated blood in 2008 and 2009, the distribution of blood components from the claim data of health insurance in 2009, the distribution of HBsAg and HBsAb of recipients, and some assumptions, we quantified the number of recipients in Korea that might be expected to receive HBV-contaminated blood components, as a proxy index for HBV infection by transfusion in 2009. Of the 376,211 recipients, the number who might be expected to receive blood components with HBV in 2009 was 23.2 (95 % CI 13.6, 36.8) in the basic model, 43.2 (95 % CI 25.4, 68.7) in extended model I, 55.2 (95 % CI 32.5, 87.7) in extended model II and 101.6 (95 % CI 59.8, 161.4) in extended model III. The number of HBV-positive samples per 100,000 transfused units was 0.6 in the basic model (95 % CI 0.3, 0.9), 1.1 in extended model I (95 % CI 0.6, 1.8), 1.4 in extended model II (95 % CI 0.8, 2.2), and 2.6 in extended model III (95 % CI 1.5, 4.1). This study showed that a few recipients might receive HBV-contaminated blood component by transfusion. These results could be used as a scientific evidence for health policy on HBV transfusion infection.
authors.affiliation: Department of Preventive Medicine, School of Medicine, Konkuk University, Achasanro 263, Gwangjin-gu, Seoul, 143-701 Korea.
authors.forename: Kunsei
authors.initials: K
authors.lastname: Lee
authors.affiliation: Department of Preventive Medicine, School of Medicine, Konkuk University, Achasanro 263, Gwangjin-gu, Seoul, 143-701 Korea.
authors.forename: Hyeongsu
authors.initials: H
authors.lastname: Kim
authors.affiliation: Department of Preventive Medicine, School of Medicine, Konkuk University, Achasanro 263, Gwangjin-gu, Seoul, 143-701 Korea.
authors.forename: Sounghoon
authors.initials: S
authors.lastname: Chang
authors.affiliation: Department of Laboratory Medicine, School of Medicine, Konkuk University, Seoul, Korea.
authors.forename: Mina
authors.initials: M
authors.lastname: Hur
authors.affiliation: Department of Preventive Medicine, School of Medicine, Konkuk University, Achasanro 263, Gwangjin-gu, Seoul, 143-701 Korea.
authors.forename: Vitna
authors.initials: V
authors.lastname: Kim
authors.affiliation: Department of Preventive Medicine, School of Medicine, Konkuk University, Achasanro 263, Gwangjin-gu, Seoul, 143-701 Korea.
authors.forename: Hyoseon
authors.initials: H
authors.lastname: Jeong
authors.affiliation: Labgenomics Clinical Laboratories, Seongnam, Korea.
authors.forename: Dong Hee
authors.initials: DH
authors.lastname: Seo
authors.affiliation: Division of Epidemic Intelligence Service, Korea Centers for Disease Control & Prevention, Cheongju, Korea.
authors.forename: SangWon
authors.initials: S
authors.lastname: Lee
authors.affiliation: Department of Nursing, College of Medicine, Hallym University, Chuncheon, Korea.
authors.forename: Eun Jung
authors.initials: EJ
authors.lastname: Kim
authors.affiliation: Department of Public Health Administration, Hanyang Women's University, Seoul, Korea.
authors.forename: Eunyoung
authors.initials: E
authors.lastname: Shin
authors.affiliation: Division of Infectious Disease Control, Korea Centers for Disease Control & Prevention, Cheongju, Korea.
authors.forename: Young Tack
authors.initials: YT
authors.lastname: Kim
keywords: Blood component; Hepatitis B; Residual risk; Transfusion