title: [Association between function of selenium and heart disease].
abstract: An excessive oxidative stress is considered to be responsible for the development and progression of heart disease. Deficiency of trace elements with antioxidative activities is present in patients with heart disease. Selenium (Se) is an integral part of the enzyme glutathione peroxidase(GPx), one of the central players of the heart's antioxidant system, and it's deficiency is implicated in certain types of heart disease. Our study suggests that myocardial oxidative stress in chronic heart failure may be augmented at least in part by concomitant GPx deficiency, and that the administration of Se could rescue the exhaustion of this selenoprotein, resulting in improved left ventricular function.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Hiraoka
mesh_terms: D000975:Antioxidants / Q000008:administration & dosage / Q000378:metabolism; D004032:Diet; D005979:Glutathione Peroxidase / Q000378:metabolism; D006331:Heart Diseases / Q000378:metabolism*; D006801:Humans; D018384:Oxidative Stress; D012643:Selenium / Q000008:administration & dosage / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D005979:Glutathione Peroxidase; D012643:Selenium