title: Acute Leukemia with a Translocation T(4;11)(q21;q23): a Distinct Clinicopathological Entity: Report of a Case with Cytogenetic Clonal Evolution and Review of 146 Cases of the Literature.
abstract: We present a cytogenetic clonal evolution that correlates morphological and immunological shifts in a case of a patient with a t(4;11) (q21;q23) acute leukemia. We take this opportunity to review 146 cases reported so far, with special reference to morphology, immunophenotyping, cytogenetics, clinical characteristics and evolution. Particular features are underlined, and prognosis, leukemic stem cell origin, chromosomal breakpoints and genes involved are discussed. A relationship between this type of leukemia and exposure to carcinogens is suggested by a high rate of secondary leukemia in adults and a high frequency in newborns and infants.
authors.affiliation: a Hematology Laboratory Centre Hospitalier Universitaire de Brest, and Centre d'Ecologie Cellulaire, Hôpital de la Salpétriétre, Paris, France.
authors.forename: M C
authors.initials: MC
authors.lastname: Léglise
authors.affiliation: b Cytogenetics Laboratory Centre Hospitalier Universitaire de Brest, and Centre d'Ecologie Cellulaire, Hôpital de la Salpétriétre, Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Rivière
authors.affiliation: c Department of Onco-Hematology Centre Hospitalier Universitaire de Brest, Centre d'Ecologie Cellulaire, Hôpital de la Salpétriétre, Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Brière
keywords: Acute leukemia; chromosome 11; chromosome 4; clonal evolution; phenotype; translocation