title: Primary Brachial Plexus Tumors: Clinical Experiences of 143 Cases.
abstract: OBJECTIVE
  Primary brachial plexus tumors are extremely rare and the treatment is challengeable. Our aim is to share the experiences in the treatment of primary brachial plexus tumors.
  
  
  METHODS
  A retrospective analysis of 143 patients with primary brachial plexus tumors was made in our department from January 2001 to December 2012. The clinical presentation of the patients, the characteristics and pathological results of the tumors and the prognosis were described.
  
  
  RESULTS
  Seventy-eight males and sixty-five female were enrolled. The mean age was 48.17 years old. A palpable mass was the most common clinical presentation occurred in 129 patients. The trunks of the brachial plexus were the locations where the tumors originated with high possibility, with 68 cases. Benign tumors were composed of 119 schwannomas and 12 neurofibromas, while malignant tumors were composed of 8 malignant peripheral nerve sheath tumors, 2 malignant granular cell tumors, 1 synovial sarcoma and 1 peripheral primitive neuroectodermal tumor. Appropriate surgical method, radiotherapy and chemotherapy were used according to the condition during operation, preoperative examinations and pathological result. The survival rate was 50.00% with a 3-year follow-up. Local recurrence happened in 7 patients. Five patients presented Metastasis.
  
  
  CONCLUSIONS
  Appropriate surgical method is the key for the treatment of different brachial plexus tumors. Surgery has a great effect on the treatment of benign tumors. For malignant tumors, adjuvant radiotherapy or chemotherapy should be used according to the pathological result. The general prognosis for malignant brachial plexus tumors is less than ideal.
authors.affiliation: Department of Hand Surgery, Huashan Hospital, Fudan University, Key Laboratory of Hand Reconstruction, Ministry of Health, Key Laboratory of Peripheral Nerve and Microsurgery, Shanghai, China. Electronic address: 895246690@qq.com.
authors.forename: Xiaotian
authors.initials: X
authors.lastname: Jia
authors.affiliation: Department of Hand Surgery, Huashan Hospital, Fudan University, Key Laboratory of Hand Reconstruction, Ministry of Health, Key Laboratory of Peripheral Nerve and Microsurgery, Shanghai, China. Electronic address: jianyun@tom.com.
authors.forename: Jianyun
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Hand Surgery, Huashan Hospital, Fudan University, Key Laboratory of Hand Reconstruction, Ministry of Health, Key Laboratory of Peripheral Nerve and Microsurgery, Shanghai, China. Electronic address: 346269081@qq.com.
authors.forename: Lin
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Hand Surgery, Huashan Hospital, Fudan University, Key Laboratory of Hand Reconstruction, Ministry of Health, Key Laboratory of Peripheral Nerve and Microsurgery, Shanghai, China. Electronic address: 875445584@qq.com.
authors.forename: Cong
authors.initials: C
authors.lastname: Yu
authors.affiliation: Division of Pharmacoproteomics, National Cancer Center Research Institute, Tokyo, Japan. Electronic address: kevinrggg@hotmail.com.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Kondo
mesh_terms: D000328:Adult; D001917:Brachial Plexus / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010524:Peripheral Nervous System Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D011379:Prognosis; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: malignant granular cell tumor; malignant peripheral nerve sheath tumor; neurofibroma; peripheral primitive neuroectodermal tumor; primary brachial plexus tumor; schwannoma; synovial sarcoma