title: The Contribution of Biomechanical-Biological Interactions of the Spine to Low Back Pain.
abstract: The objective of this mini-review is to examine a subset of literature that demonstrates multiple interactions between mechanics and biology within the spine and propose how incorporation of these mechano-biologic interactions can be applied to improve the conceptual understanding of tissue tolerances.
  
  
  
  Low back pain represents a major musculoskeletal problem in the workplace. Traditional biomechanical assessments have employed tissue tolerances as an approach for reducing workplace injuries; however, development of more universal biologically sensitive tolerances requires incorporation of mechano-biologic interactions.
  
  
  
  A focused literature review addressing the interactions between mechanical loading and biology in the spine.
  
  
  
  Mechanical loads applied to the body are distributed across all spatial scales from the body to the tissues to the cells. These mechanical loads regulate cellular metabolism and over time can lead to tissue strengthening or weakening. Mechanical loading also interacts with the biologic environment (e.g., tissue inflammation, nerve sensitization) to influence the perception of pain, thereby changing the risk of experiencing pain. Biologic tissues also exhibit time-dependent changes in mechanical behaviors that occur throughout the day and with disease, suggesting tissue tolerances are time dependent.
  
  
  
  Incorporating mechano-biologic interactions into the traditional tissue tolerance paradigm through describing tissue tolerances as a function of multiple factors (e.g., preexisting risk factors, underlying pathology, and time) may lead to the development of tissue tolerances that are more representative of the in vivo situation.
  
  
  
  Efforts must work toward incorporating biological concepts into tissue tolerances in order to improve risk assessment tools.
authors.affiliation: Shared first authorship marras.1@osu.edu.
authors.forename: William S
authors.initials: WS
authors.lastname: Marras
authors.affiliation: Shared first authorship.
authors.forename: Benjamin A
authors.initials: BA
authors.lastname: Walter
authors.forename: Devina
authors.initials: D
authors.lastname: Purmessur
authors.forename: Prasath
authors.initials: P
authors.lastname: Mageswaran
authors.forename: Matthew G
authors.initials: MG
authors.lastname: Wiet
mesh_terms: D001696:Biomechanical Phenomena / Q000502:physiology*; D006801:Humans; D017116:Low Back Pain / Q000503:physiopathology*; D013131:Spine / Q000502:physiology*
keywords: biomechanical models–spine; job risk assessment; low back; physiology; spine; tissue loading