title: PHOTODYNAMIC THERAPY FOR CHOROIDAL NEVUS WITH SUBFOVEAL FLUID.
abstract: OBJECTIVE
  To report the efficacy of photodynamic therapy (PDT) for management of choroidal nevus associated with subfoveal fluid.
  
  
  METHODS
  A retrospective chart review of 15 patients with choroidal nevus and associated subfoveal fluid treated with PDT was performed. Standard-fluence PDT was used in all patients and response to treatment was assessed with optical coherence tomography.
  
  
  RESULTS
  Complete resolution of subfoveal fluid was achieved in 9 eyes (60%) and partial resolution in 4 eyes (27%); 1 eye (7%) experienced worsening subfoveal fluid, and 1 eye (7%) was stable after PDT. After PDT, visual acuity improved in 8 eyes (53%), was stable in 6 (40%), and worsened in 1 eye (7%). Five patients (33%) required a second session of PDT with a median of 4 months (mean, 9 months; range 2-25 months) between the first and second sessions of PDT.
  
  
  CONCLUSIONS
  Photodynamic therapy is a safe and effective treatment modality for choroidal nevus with subfoveal fluid. Photodynamic therapy provided satisfactory rates of resolution of subfoveal fluid in 87%, which was complete in 60% and partial in 27%. Further studies could further define the role and limitations of PDT for management of subfoveal fluid from choroidal nevus.
authors.affiliation: Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.
authors.forename: Renelle
authors.initials: R
authors.lastname: Pointdujour-Lim
authors.forename: Arman
authors.initials: A
authors.lastname: Mashayekhi
authors.forename: Jerry A
authors.initials: JA
authors.lastname: Shields
authors.forename: Carol L
authors.initials: CL
authors.lastname: Shields
mesh_terms: D000328:Adult; D000368:Aged; D002830:Choroid Neoplasms / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D011166:Porphyrins / Q000627:therapeutic use*; D012189:Retrospective Studies; D058471:Subretinal Fluid / Q000378:metabolism*; D000077362:Verteporfin; D014792:Visual Acuity
chemical_list: D017319:Photosensitizing Agents; D011166:Porphyrins; D000077362:Verteporfin