title: Obesity and cancer: inflammation bridges the two.
abstract: Obesity is a growing public health problem and affects 35% US adults. Obesity increases the risk of many cancer types and is associated with poor outcomes. Clinical management of cancer patients has been essentially the same between normal weight and obese individuals. Understanding causal mechanisms by which obesity drives cancer initiation and progression is essential for the development of novel precision therapy for obese cancer patients. One caveat is that various mechanisms have been proposed for different cancer types for their progression under obesity. Since obesity is known to have global impact on inflammation, here we will summarize recent literature and discuss the potential of inflammation being the common causal mechanism to promote cancer promotion across cancer types.
authors.affiliation: Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
authors.forename: Ryan
authors.initials: R
authors.lastname: Kolb
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
authors.forename: Fayyaz S
authors.initials: FS
authors.lastname: Sutterwala
authors.affiliation: Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA, USA; Interdisciplinary Graduate Program in Immunology, University of Iowa Carver College of Medicine, Iowa City, IA, USA; Medical Scientist Training Program, University of Iowa Carver College of Medicine, Iowa City, IA, USA; Free Radical and Radiation Biology Program, University of Iowa Carver College of Medicine, Iowa City, IA, USA; Cancer Genes and Pathway Holden Comprehensive Cancer Center, University of Iowa Carver College of Medicine, Iowa City, IA, USA. Electronic address: weizhou-zhang@uiowa.edu.
authors.forename: Weizhou
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000818:Animals; D001835:Body Weight; D018450:Disease Progression; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000276:immunology / Q000473:pathology; D009369:Neoplasms / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D009765:Obesity / Q000150:complications* / Q000453:epidemiology / Q000276:immunology; D014481:United States / Q000453:epidemiology