title: Modulation of Interleukins in Sepsis-Associated Clotting Disorders: Interplay With Hemostatic Derangement.
abstract: Interleukins play a central role in the immune system and are involved in a variety of immunological, inflammatory, and infectious disease states including sepsis syndrome. Levels of interleukins may correlate with overall survival and may directly or indirectly affect some of the regulators of coagulation and fibrinolysis, thereby disrupting hemostasis and thrombosis. Our hypothesis is that in sepsis-associated coagulopathies (SACs), interleukins may be upregulated, leading to hemostatic imbalance by generating thrombogenic mediators. We profiled the levels of interleukins IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, and IL-10 in addition to d-dimer (DD) in patients with SAC and in normal donors. We observed the highest increase in interleukins IL-6 (322-fold), IL-8 (48-fold), IL-10 (72-fold), and DD (18-fold). This suggests that interleukins such as IL-6 and IL-10 have a close association with coagulopathy and fibrinolytic dysregulation in sepsis and can be considered as candidates for potential therapeutic targets in SAC.
authors.affiliation: Department of Pathology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Low
authors.affiliation: Department of Pathology and Pharmacology, Loyola University Medical Center, Maywood, IL, USA.
authors.forename: Daneyal
authors.initials: D
authors.lastname: Syed
authors.affiliation: Department of Pathology and Pharmacology, Loyola University Medical Center, Maywood, IL, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Khan
authors.affiliation: Biochemistry Department, Marmara University, Istanbul, Turkey.|Cyprus International University, Nicosia, Northern Cyprus.
authors.forename: Sermin
authors.initials: S
authors.lastname: Tetik
authors.affiliation: Department of Pathology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA.
authors.forename: Amanda
authors.initials: A
authors.lastname: Walborn
authors.affiliation: Department of Pathology and Pharmacology, Loyola University Medical Center, Maywood, IL, USA.
authors.forename: Debra
authors.initials: D
authors.lastname: Hoppensteadt
authors.affiliation: Department of Surgery, Loyola University Medical Center, Maywood, IL, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Mosier
authors.affiliation: Department of Pathology and Pharmacology, Loyola University Medical Center, Maywood, IL, USA jfareed@luc.edu.
authors.forename: Jawed
authors.initials: J
authors.lastname: Fareed
mesh_terms: D001778:Blood Coagulation Disorders / Q000150:complications*; D006490:Hemostatics / Q000494:pharmacology*; D006801:Humans; D007378:Interleukins; D018805:Sepsis / Q000097:blood*
chemical_list: D006490:Hemostatics; D007378:Interleukins
keywords: hemostasis; interleukins; sepsis-associated coagulopathy