title: Cross-reactivity between voriconazole, fluconazole and itraconazole.
abstract: OBJECTIVE
  Hypersensitivity to triazoles is a rare occurrence and cross-reactivity between agents is unknown. We present a successful voriconazole challenge in a patient allergic to fluconazole and itraconazole.
  
  
  METHODS
  A 41-year-old immunocompetent male with coccidioidomycosis developed fever, eosinophilia and maculopapular rash from fluconazole. Switching to itraconazole resulted in worsening of the rash and skin sloughing over 25% of his body. He was given an oral-graded challenge of voriconazole which he tolerated without incident.
  
  
  CONCLUSIONS
  This is the first report of a lack of cross-reactivity between itraconazole and voriconazole.
authors.affiliation: Western University of Health Sciences, Pomona, CA, USA.|VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
authors.forename: D
authors.initials: D
authors.lastname: Benjamin Lash
authors.affiliation: Department of Pharmacy, Kern Medical, Bakersfield, CA, USA.
authors.forename: J
authors.identifier: http://orcid.org/0000-0001-7598-5965
authors.initials: J
authors.lastname: Jolliff
authors.affiliation: Department of Medicine, Kern Medical, Bakersfield, CA, USA.
authors.forename: A
authors.initials: A
authors.lastname: Munoz
authors.affiliation: Department of Medicine, Kern Medical, Bakersfield, CA, USA.
authors.forename: A
authors.initials: A
authors.lastname: Heidari
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000009:adverse effects*; D003429:Cross Reactions / Q000187:drug effects*; D004342:Drug Hypersensitivity / Q000209:etiology; D015725:Fluconazole / Q000009:adverse effects*; D006801:Humans; D017964:Itraconazole / Q000009:adverse effects*; D008297:Male; D065819:Voriconazole / Q000009:adverse effects*
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D015725:Fluconazole; D065819:Voriconazole
keywords: allergy; fluconazole; itraconazole; voriconazole