title: Design and Applications of Protein-Cage-Based Nanomaterials.
abstract: Materials science is beginning to focus on biotemplation, and in support of that trend, it is realized that protein cages-proteins that assemble from multiple monomers into architectures with hollow interiors-can instill a number of unique advantages to nanomaterials. In addition, the structural and functional plasticity of many protein-cage systems permits their engineering for specific applications. In this review, the most commonly used viral and non-viral protein cages, which exhibit a wide diversity of size, functionality, and chemical and thermal stabilities, are described. Moreover, how they have been exploited for nanomaterial and nanotechnology applications is summarized.
authors.affiliation: Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals, College of Chemical Engineering, Nanjing Forestry University, Nanjing, 210037, P.R. China. yuzhang@njfu.edu.cn.
authors.forename: Yu
authors.identifier: http://orcid.org/0000-0002-2614-5975
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, The Scripps Research Institute, La Jolla, CA, 92037, United States.
authors.forename: Maziar S
authors.initials: MS
authors.lastname: Ardejani
authors.affiliation: Department of Chemistry, King's College London, London, SE1 1DB, United Kingdom. brendan.orner@kcl.ac.uk.
authors.forename: Brendan P
authors.initials: BP
authors.lastname: Orner
mesh_terms: D001435:Bacteriophages / Q000378:metabolism; D017795:Bromovirus / Q000378:metabolism; D036022:Capsid Proteins / Q000737:chemistry / Q000378:metabolism; D017798:Comovirus / Q000378:metabolism; D005293:Ferritins / Q000737:chemistry / Q000378:metabolism; D050888:Heat-Shock Proteins, Small / Q000737:chemistry / Q000378:metabolism; D049329:Nanostructures / Q000737:chemistry*; D015202:Protein Engineering; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D013499:Surface Properties; D014027:Tobacco Mosaic Virus / Q000378:metabolism
chemical_list: D036022:Capsid Proteins; D050888:Heat-Shock Proteins, Small; D011506:Proteins; D005293:Ferritins
keywords: cage compounds; nanoparticles; protein design; protein structures; viruses