title: Genetic relationship between the Echinococcus granulosus sensu stricto cysts located in lung and liver of hosts.
abstract: G1 genotype of Echinococcus granulosus sensu stricto is the major cause of hydatidosis in Northern Africa, Tunisia included. The genetic relationship between lung and liver localization were studied in ovine, bovine and human hydatid cysts in Tunisia. Allozyme variation and single strand conformation polymorphism were used for genetic differentiation. The first cause of genetic differentiation was the host species and the second was the localization (lung or liver). The reticulated genetic relationship between the liver or the lung human isolates and isolates from bovine lung, is indicative of recombination (sexual reproduction) or lateral genetic transfer. The idea of two specialized populations (one for the lung one for the liver) that are more or less successful according to host susceptibility is thus proposed.
authors.affiliation: LP3M: Laboratory of Medical and Molecular Parasitology-Mycology, LR12ES08, Faculty of Pharmacy, University of Monastir, 5000 Monastir, Tunisia. Electronic address: myriam.mrad@gnet.tn.
authors.forename: Myriam
authors.initials: M
authors.lastname: Oudni-M'rad
authors.affiliation: UMR 1282, ISP INRA and F. Rabelais University, 37380 Nouzilly, France. Electronic address: Jacques.Cabaret@tours.inra.fr.
authors.forename: Jacques
authors.initials: J
authors.lastname: Cabaret
authors.affiliation: LP3M: Laboratory of Medical and Molecular Parasitology-Mycology, LR12ES08, Faculty of Pharmacy, University of Monastir, 5000 Monastir, Tunisia. Electronic address: selim.mrad@gnet.tn.
authors.forename: Selim
authors.initials: S
authors.lastname: M'rad
authors.affiliation: LP3M: Laboratory of Medical and Molecular Parasitology-Mycology, LR12ES08, Faculty of Pharmacy, University of Monastir, 5000 Monastir, Tunisia. Electronic address: raja.chaabane@laposte.net.
authors.forename: Raja
authors.initials: R
authors.lastname: Chaâbane-Banaoues
authors.affiliation: Department of Paediatric Surgery and LR12SP13, University Hospital F. Bourguiba, 5000 Monastir, Tunisia. Electronic address: mongi.mekki@rns.tn.
authors.forename: Mongi
authors.initials: M
authors.lastname: Mekki
authors.affiliation: Central Slaughterhouse of Sousse, 4000 Sousse, Tunisia. Electronic address: zmantar.sofien@yahoo.fr.
authors.forename: Sofien
authors.initials: S
authors.lastname: Zmantar
authors.affiliation: Department of Paediatric Surgery and LR12SP13, University Hospital F. Bourguiba, 5000 Monastir, Tunisia. Electronic address: nouri.abdellatif@rns.tn.
authors.forename: Abdellatif
authors.initials: A
authors.lastname: Nouri
authors.affiliation: LP3M: Laboratory of Medical and Molecular Parasitology-Mycology, LR12ES08, Faculty of Pharmacy, University of Monastir, 5000 Monastir, Tunisia. Electronic address: habib.mezhoud@laposte.net.
authors.forename: Habib
authors.initials: H
authors.lastname: Mezhoud
authors.affiliation: LP3M: Laboratory of Medical and Molecular Parasitology-Mycology, LR12ES08, Faculty of Pharmacy, University of Monastir, 5000 Monastir, Tunisia; Laboratory of Parasitology, University Hospital F. Bourguiba, 5000 Monastir, Tunisia. Electronic address: hamouda.babba@rns.tn.
authors.forename: Hamouda
authors.initials: H
authors.lastname: Babba
mesh_terms: D000483:Alleles; D000818:Animals; D002417:Cattle; D004198:Disease Susceptibility; D004444:Echinococcosis, Hepatic / Q000469:parasitology* / Q000473:pathology*; D004445:Echinococcosis, Pulmonary / Q000469:parasitology* / Q000473:pathology*; D048209:Echinococcus granulosus / Q000145:classification* / Q000235:genetics*; D056426:Genetic Loci; D014644:Genetic Variation; D005838:Genotype; D006790:Host-Parasite Interactions; D006801:Humans; D015810:Linkage Disequilibrium; D010802:Phylogeny; D011529:Protozoan Infections, Animal / Q000469:parasitology / Q000473:pathology; D012756:Sheep
keywords: Echinococcus granulosus; G1 genotype; Genetic variation; Liver; Lung