title: Chemical Composition and Biological Activity of Centaurea baseri: New Species from Turkey.
abstract: The genus Centaurea L. is one of the largest and important genera of Asteraceae family. Centaurea species have been widely used as herbal remedies in folk medicine for their antidandruff, antidiarrheic, antirheumatic, anti-inflammatory, choleretic, diuretic, digestive, stomachic, astringent, antipyretic, cytotoxic, and antibacterial properties. Centaurea baseri Kose & Alan is a recently described local endemic species in Turkey and this is the first study on the chemical composition and bioactivity of its hydrodistilled essential oil and the crude extract. According to chromatospectral analysis, hexadecanoic acid (42.3%), nonacosane (8.2%), and heptacosane (8.0%) were the main compounds of the essential oil, while 16 compounds were determined in the MeOH extract using LC/MS. Furthermore, antimicrobial, antioxidant, and cytotoxic effects of the essential oil and the extract were evaluated in comparison with the standard agents. The extract showed strong antifungal effect against Candida utilis at the concentration of 60 μg/ml (MIC) where the EO showed growth inhibition at the concentration of 47.00 μg/ml (MIC) against pathogen Bacillus cereus. Both the essential oil and the extract did not show any selective antioxidant properties. The extract showed remarkably selective cytotoxic properties against MCF-7, PANC-1, A549, and C6 glioma cells.
authors.affiliation: Department of Pharmaceutical Botany, Faculty of Pharmacy, Anadolu University, TR-26470, Eskisehir.
authors.forename: Yavuz Bülent
authors.initials: YB
authors.lastname: Köse
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, TR-26470, Eskisehir. giscan@anadolu.edu.tr.|Yunus Emre Vocational School, Anadolu University, TR-26470, Eskisehir. giscan@anadolu.edu.tr.
authors.forename: Gökalp
authors.initials: G
authors.lastname: İşcan
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, TR-26470, Eskisehir.
authors.forename: Fatih
authors.initials: F
authors.lastname: Göger
authors.affiliation: Department of Biochemistry, Faculty of Pharmacy, Anadolu University, TR-26470, Eskisehir.
authors.forename: Gülşen
authors.initials: G
authors.lastname: Akalın
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, TR-26470, Eskisehir.
authors.forename: Betül
authors.initials: B
authors.lastname: Demirci
authors.affiliation: Department of Botany and Microbiology, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia.|Department of Pharmacognosy, Faculty of Pharmacy, Near East University, 99138, Nicosia, N. Cyprus.
authors.forename: Kemal Hüsnü Can
authors.initials: KH
authors.lastname: Başer
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001409:Bacillus cereus / Q000187:drug effects / Q000254:growth & development; D002175:Candida / Q000187:drug effects / Q000254:growth & development; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D031179:Centaurea / Q000737:chemistry* / Q000145:classification*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008826:Microbial Sensitivity Tests; D009822:Oils, Volatile / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013045:Species Specificity; D013329:Structure-Activity Relationship; D014421:Turkey
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D009822:Oils, Volatile
keywords: 
  Centaurea baseri
  ; Bioactivities; Essential oil; LC/MS, GC/MS; MeOH extract