title: Methotrexate and etanercept-induced primary cutaneous CD4 positive small/medium-sized pleomorphic T-cell lymphoma.
abstract: Immunosuppressive drugs and biological agents may represent a potential risk of lymphoma development in patients with rheumatoid arthritis. But most cases are diffuse, large B-cell lymphomas. Primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoma, a provisional entity in the 2005 WHO-EORTC classification of cutaneous lymphomas, is only described in a limited number of reports. To our knowledge, our case is a rare instance of primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoma, after associated treatment with methotrexate and etanercept, in a patient with moderate rheumatoid arthritis who had undergone an orchidectomy incorrectly.
authors.affiliation: Third Affiliated Hospital, Sun Yat-sen University - Guangdong, China.
authors.forename: Han
authors.initials: H
authors.lastname: Ma
authors.affiliation: Third Affiliated Hospital, Sun Yat-sen University - Guangdong, China.
authors.forename: Shu
authors.initials: S
authors.lastname: Qiu
authors.affiliation: Third Affiliated Hospital, Sun Yat-sen University - Guangdong, China.
authors.forename: Rongbiao
authors.initials: R
authors.lastname: Lu
authors.affiliation: Third Affiliated Hospital, Sun Yat-sen University - Guangdong, China.
authors.forename: Peiying
authors.initials: P
authors.lastname: Feng
authors.affiliation: Third Affiliated Hospital, Sun Yat-sen University - Guangdong, China.
authors.forename: Chun
authors.initials: C
authors.lastname: Lu
mesh_terms: D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D000068800:Etanercept / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016410:Lymphoma, T-Cell, Cutaneous / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*; D008875:Middle Aged; D009919:Orchiectomy; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000473:pathology; D013733:Testicular Diseases / Q000175:diagnosis / Q000601:surgery
chemical_list: D007166:Immunosuppressive Agents; D000068800:Etanercept; D008727:Methotrexate