title: Quantification of choroidal neovascularization vessel length using optical coherence tomography angiography.
abstract: Quantification of choroidal neovascularization (CNV) as visualized by optical coherence tomography angiography (OCTA) may have importance clinically when diagnosing or tracking disease. Here, we present an automated algorithm to quantify the vessel skeleton of CNV as vessel length. Initial segmentation of the CNV on en face angiograms was achieved using saliency-based detection and thresholding. A level set method was then used to refine vessel edges. Finally, a skeleton algorithm was applied to identify vessel centerlines. The algorithm was tested on nine OCTA scans from participants with CNV and comparisons of the algorithm’s output to manual delineation showed good agreement.
authors.affiliation: Oregon Health and Science University, Casey Eye Institute, 3375 NW Terwilliger Boulevard, Portland, Oregon 97239, United States.
authors.forename: Simon S
authors.initials: SS
authors.lastname: Gao
authors.affiliation: Oregon Health and Science University, Casey Eye Institute, 3375 NW Terwilliger Boulevard, Portland, Oregon 97239, United StatesbSoutheast University, Laboratory of Image Science and Technology, Department of Computer Science and Engineering, No. 2 Sipailo.
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.affiliation: Oregon Health and Science University, Casey Eye Institute, 3375 NW Terwilliger Boulevard, Portland, Oregon 97239, United States.
authors.forename: Steven T
authors.initials: ST
authors.lastname: Bailey
authors.affiliation: Oregon Health and Science University, Casey Eye Institute, 3375 NW Terwilliger Boulevard, Portland, Oregon 97239, United States.
authors.forename: Christina J
authors.initials: CJ
authors.lastname: Flaxel
authors.affiliation: Oregon Health and Science University, Casey Eye Institute, 3375 NW Terwilliger Boulevard, Portland, Oregon 97239, United States.
authors.forename: David
authors.initials: D
authors.lastname: Huang
authors.affiliation: Shandong Normal University, Shandong Province Key Laboratory of Medical Physics and Image Processing Technology, School of Physics and Electronics, 88 East Wenhua Road, Jinan, Shandong 250014, China.
authors.forename: Dengwang
authors.initials: D
authors.lastname: Li
authors.affiliation: Oregon Health and Science University, Casey Eye Institute, 3375 NW Terwilliger Boulevard, Portland, Oregon 97239, United States.
authors.forename: Yali
authors.initials: Y
authors.lastname: Jia
mesh_terms: D000465:Algorithms; D020256:Choroidal Neovascularization / Q000000981:diagnostic imaging*; D003952:Diagnostic Imaging / Q000295:instrumentation / Q000379:methods* / Q000592:standards; D005451:Fluorescein Angiography; D006801:Humans; D015203:Reproducibility of Results; D041623:Tomography, Optical Coherence