title: Asymmetric synthesis of bicyclic dihydropyrans via organocatalytic inverse-electron-demand oxo-Diels-Alder reactions of enolizable aliphatic aldehydes.
abstract: A highly enantioselective organocatalytic inverse-electron-demand oxo-Diels-Alder reaction involving aqueous acetaldehyde has been discovered. The reaction, in which cyclic enones serve as dienes in the presence of readily available secondary amine catalysts, allows facile construction of optically active bicyclic dihydropyrans. Other typical enolizable aliphatic aldehydes can also serve as competent dienophiles in the reaction.
authors.affiliation: Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu 610052, P. R. China. Kaichuanyang@163.com gouxj@163.com.
authors.forename: Jun-Long
authors.initials: JL
authors.lastname: Li
authors.affiliation: Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu 610052, P. R. China. Kaichuanyang@163.com gouxj@163.com and Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China.
authors.forename: Kai-Chuan
authors.initials: KC
authors.lastname: Yang
authors.affiliation: Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu 610052, P. R. China. Kaichuanyang@163.com gouxj@163.com.
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.affiliation: Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu 610052, P. R. China. Kaichuanyang@163.com gouxj@163.com.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.affiliation: Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu 610052, P. R. China. Kaichuanyang@163.com gouxj@163.com.
authors.forename: Hong-Ping
authors.initials: HP
authors.lastname: Zhu
authors.affiliation: State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China. pengcheng@cdutcm.edu.cn.
authors.forename: Bo
authors.initials: B
authors.lastname: Han
authors.affiliation: State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China. pengcheng@cdutcm.edu.cn.
authors.forename: Cheng
authors.initials: C
authors.lastname: Peng
authors.affiliation: Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China.
authors.forename: Yong-Gang
authors.initials: YG
authors.lastname: Zhi
authors.affiliation: Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu 610052, P. R. China. Kaichuanyang@163.com gouxj@163.com.
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Gou