title: A New Class of Glucosyl Thioureas: Synthesis and Larvicidal Activities.
abstract: A novel series of glucosyl thioureas were synthesized in good overall yields (up to 37% over four steps) from d-glucose and primary amines, and their larvicidal activities toward Mythimna separata Walker were also investigated. This new class of glucosyl thioureas demonstrated low to moderate growth inhibition activity of Mythiman separata Walker, with a growth inhibitory rate of up to 47.5% at a concentration of 100.0 mg/L in acetone.
authors.affiliation: Department of Medicinal Chemistry, School of Pharmacy, The Fourth Military Medical University, Changle West Road 169, Xi'an 710032, China. ping_an1718@outlook.com.
authors.forename: Ping-An
authors.initials: PA
authors.lastname: Wang
authors.affiliation: Research &amp; Department Center of Biorational Pesticides, Northwest Agriculture &amp; Forestry University, No. 3 Taicheng Road, Yangling 712100, China. jtfeng@126.com.
authors.forename: Jun-Tao
authors.initials: JT
authors.lastname: Feng
authors.affiliation: Department of Medicinal Chemistry, School of Pharmacy, The Fourth Military Medical University, Changle West Road 169, Xi'an 710032, China. 13299079818@163.com.
authors.forename: Xing-Zi
authors.initials: XZ
authors.lastname: Wang
authors.affiliation: Department of Medicinal Chemistry, School of Pharmacy, The Fourth Military Medical University, Changle West Road 169, Xi'an 710032, China. limuqiong1981@163.com.
authors.forename: Mu-Qiong
authors.initials: MQ
authors.lastname: Li
mesh_terms: D000818:Animals; D005947:Glucose / Q000737:chemistry*; D007306:Insecticides / Q000138:chemical synthesis / Q000494:pharmacology; D007814:Larva / Q000187:drug effects; D015394:Molecular Structure; D009036:Moths / Q000187:drug effects; D013890:Thiourea / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D007306:Insecticides; D013890:Thiourea; D005947:Glucose
keywords: anti-chitin structure; chitin synthase inhibitor; glucosyl thiourea; growth inhibitory rate; larvicidal activity