title: From Artificial Amino Acids to Sequence-Defined Targeted Oligoaminoamides.
abstract: Artificial oligoamino acids with appropriate protecting groups can be used for the sequential assembly of oligoaminoamides on solid-phase. With the help of these oligoamino acids multifunctional nucleic acid (NA) carriers can be designed and produced in highly defined topologies. Here we describe the synthesis of the artificial oligoamino acid Fmoc-Stp(Boc3)-OH, the subsequent assembly into sequence-defined oligomers and the formulation of tumor-targeted plasmid DNA (pDNA) polyplexes.
authors.affiliation: Pharmaceutical Biotechnology, Center for System-based Drug Research, Ludwig-Maximilians-University Munich, Butenandtstrasse 5-13, Munich, Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Morys
authors.affiliation: Pharmaceutical Biotechnology, Center for System-based Drug Research, Ludwig-Maximilians-University Munich, Butenandtstrasse 5-13, Munich, Germany.|Nanosystems Initiative, Munich, Germany.
authors.forename: Ernst
authors.initials: E
authors.lastname: Wagner
authors.affiliation: Pharmaceutical Biotechnology, Center for System-based Drug Research, Ludwig-Maximilians-University Munich, Butenandtstrasse 5-13, Munich, Germany. Ulrich.Laechelt@cup.uni-muenchen.de.|Nanosystems Initiative, Munich, Germany. Ulrich.Laechelt@cup.uni-muenchen.de.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Lächelt
mesh_terms: D000577:Amides; D000596:Amino Acids / Q000737:chemistry*; D004247:DNA / Q000235:genetics*; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D009369:Neoplasms / Q000235:genetics / Q000628:therapy; D010957:Plasmids / Q000235:genetics; D011073:Polyamines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000577:Amides; D000596:Amino Acids; D011073:Polyamines; D004247:DNA
keywords: Gene transfer; Oligoaminoamides; Polyplex; Proton-sponge; Sequence-defined; Tumor targeting; cMet