title: Anodal tDCS targeting the left temporo-parietal junction disrupts verbal reality-monitoring.
abstract: Using transcranial direct current stimulation (tDCS) we aimed to investigate the causal role of the left temporo-parietal and prefrontal regions in source-monitoring. Forty-two healthy participants received tDCS while performing a verbal reality-monitoring task (requiring discrimination between imagined and heard words) and a verbal internal source-monitoring task (requiring discrimination between imagined and said words). In 2 randomized crossover studies, 21 participants received active and sham anodal tDCS applied over the left temporo-parietal junction (TPJ) and 21 participants received active and sham cathodal tDCS applied over the left prefrontal cortex (PFC). The reference electrode was placed over the right occipital region in both experiments. Active tDCS over the left TPJ decreased reality-monitoring performance but did not modulate internal source-monitoring performance. Participants were more likely to misattribute self-generated events to externally perceived events (externalization bias). Active tDCS over the left PFC did not modulate performance of participants in both tasks. In summary, anodal tDCS applied over the left TPJ, assumed to enhance cortical excitability, can alter reality-monitoring processes in healthy subjects. Such abnormal reality-monitoring performances have been reported in hallucinating patients with schizophrenia known to display hyperactivity of the left TPJ. Our results highlighted the role of the left TPJ in self/other recognition.
authors.affiliation: INSERM U1028, CNRS UMR5292, Lyon Neuroscience Research Center, Université de Lyon, Lyon, F-69000, France; PSYR2 Team, Centre Hospitalier Le Vinatier, Université Claude Bernard Lyon 1, F-69000, Bron, France; Centre Interdisciplinaire de Recherche en Réadaptation et Intégration Sociale, Centre de recherche de l'Institut Universitaire en Santé Mentale de Québec, Université Laval, Québec, QC, Canada.
authors.forename: Marine
authors.initials: M
authors.lastname: Mondino
authors.affiliation: INSERM U1028, CNRS UMR5292, Lyon Neuroscience Research Center, Université de Lyon, Lyon, F-69000, France; PSYR2 Team, Centre Hospitalier Le Vinatier, Université Claude Bernard Lyon 1, F-69000, Bron, France; CHU Lyon, Hopital Edouard Herriot, Service de Psychiatrie des urgences, Lyon, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Poulet
authors.affiliation: INSERM U1028, CNRS UMR5292, Lyon Neuroscience Research Center, Université de Lyon, Lyon, F-69000, France; PSYR2 Team, Centre Hospitalier Le Vinatier, Université Claude Bernard Lyon 1, F-69000, Bron, France.
authors.forename: Marie-Françoise
authors.initials: MF
authors.lastname: Suaud-Chagny
authors.affiliation: INSERM U1028, CNRS UMR5292, Lyon Neuroscience Research Center, Université de Lyon, Lyon, F-69000, France; PSYR2 Team, Centre Hospitalier Le Vinatier, Université Claude Bernard Lyon 1, F-69000, Bron, France; Centre Interdisciplinaire de Recherche en Réadaptation et Intégration Sociale, Centre de recherche de l'Institut Universitaire en Santé Mentale de Québec, Université Laval, Québec, QC, Canada. Electronic address: jerome.brunelin@ch-le-vinatier.fr.
authors.forename: Jerome
authors.initials: J
authors.lastname: Brunelin
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001931:Brain Mapping; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004566:Electrodes; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006212:Hallucinations / Q000209:etiology*; D006801:Humans; D008297:Male; D010296:Parietal Lobe / Q000502:physiology*; D013702:Temporal Lobe / Q000502:physiology*; D065908:Transcranial Direct Current Stimulation / Q000009:adverse effects*; D014705:Verbal Behavior / Q000502:physiology*; D055815:Young Adult
keywords: Prefrontal cortex; Self-recognition; Source monitoring; Temporo-parietal junction; Transcranial direct current stimulation (tDCS)