title: Significance of Epicardial and Intrathoracic Adipose Tissue Volume among Type 1 Diabetes Patients in the DCCT/EDIC: A Pilot Study.
abstract: BACKGROUND
  Type 1 diabetes (T1DM) patients are at increased risk of coronary artery disease (CAD). This pilot study sought to evaluate the relationship between epicardial adipose tissue (EAT) and intra-thoracic adipose tissue (IAT) volumes and cardio-metabolic risk factors in T1DM.
  
  
  METHODS
  EAT/IAT volumes in 100 patients, underwent non-contrast cardiac computed tomography in the Diabetes Control and Complications Trial /Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study were measured by a certified reader. Fat was defined as pixels' density of -30 to -190 Hounsfield Unit. The associations were assessed using-Pearson partial correlation and linear regression models adjusted for gender and age with inverse probability sample weighting.
  
  
  RESULTS
  The weighted mean age was 43 years (range 32-57) and 53% were male. Adjusted for gender, Pearson correlation analysis showed a significant correlation between age and EAT/IAT volumes (both p<0.001). After adjusting for gender and age, participants with greater BMI, higher waist to hip ratio (WTH), higher weighted HbA1c, elevated triglyceride level, and a history of albumin excretion rate of equal or greater than 300 mg/d (AER≥300) or end stage renal disease (ESRD) had significantly larger EAT/IAT volumes.
  
  
  CONCLUSIONS
  T1DM patients with greater BMI, WTH ratio, weighted HbA1c level, triglyceride level and AER≥300/ESRD had significantly larger EAT/IAT volumes. Larger sample size studies are recommended to evaluate independency.
authors.affiliation: Los Angeles Biomedical Research institute, Torrance, California, United States of America.
authors.forename: Sirous
authors.initials: S
authors.lastname: Darabian
authors.affiliation: The Biostatistics Center, the George Washington University, Rockville, Maryland, United States of America.
authors.forename: Jye-Yu C
authors.initials: JY
authors.lastname: Backlund
authors.affiliation: The Biostatistics Center, the George Washington University, Rockville, Maryland, United States of America.
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Cleary
authors.affiliation: Los Angeles Biomedical Research institute, Torrance, California, United States of America.
authors.forename: Nasim
authors.initials: N
authors.lastname: Sheidaee
authors.affiliation: The Biostatistics Center, the George Washington University, Rockville, Maryland, United States of America.
authors.forename: Ionut
authors.initials: I
authors.lastname: Bebu
authors.affiliation: The Biostatistics Center, the George Washington University, Rockville, Maryland, United States of America.
authors.forename: John M
authors.initials: JM
authors.lastname: Lachin
authors.affiliation: Los Angeles Biomedical Research institute, Torrance, California, United States of America.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Budoff
mesh_terms: D000273:Adipose Tissue / Q000000981:diagnostic imaging*; D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging*; D058065:Diabetic Cardiomyopathies / Q000453:epidemiology; D005260:Female; D006441:Hemoglobin A / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010496:Pericardium / Q000000981:diagnostic imaging*; D010865:Pilot Projects; D035423:Thoracic Cavity / Q000000981:diagnostic imaging*; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides; D006441:Hemoglobin A