title: Neuraminidase Inhibitors from the Fruiting Body of Phellinus igniarius.
abstract: During our ongoing investigation of neuraminidase inhibitors from medicinal fungi, we found that the fruiting bodies of Phellinus igniarius exhibited significant inhibitory activity against neuraminidase from recombinant H3N2 influenza viruses. Two active compounds were isolated from the methanolic extract of P. igniarius through solvent partitioning and Sephadex LH-20 column chromatography. The active compounds were identified as phelligridins E and G on proton nuclear magnetic resonance ((1)H NMR) and electrospray ionization mass measurements. These compounds inhibited neuraminidases from recombinant rvH1N1, H3N2, and H5N1 influenza viruses, with IC50 values in the range of 0.7~8.1 µM.
authors.affiliation: Division of Biotechnology and Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Chonbuk National University, Iksan 54596, Korea.
authors.forename: Ji-Yul
authors.initials: JY
authors.lastname: Kim
authors.affiliation: Division of Biotechnology and Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Chonbuk National University, Iksan 54596, Korea.
authors.forename: Dae-Won
authors.initials: DW
authors.lastname: Kim
authors.affiliation: Division of Biotechnology and Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Chonbuk National University, Iksan 54596, Korea.
authors.forename: Byung Soon
authors.initials: BS
authors.lastname: Hwang
authors.affiliation: Division of Biotechnology and Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Chonbuk National University, Iksan 54596, Korea.
authors.forename: E-Eum
authors.initials: EE
authors.lastname: Woo
authors.affiliation: Division of Biotechnology and Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Chonbuk National University, Iksan 54596, Korea.
authors.forename: Yoon-Ju
authors.initials: YJ
authors.lastname: Lee
authors.affiliation: Division of Biotechnology and Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Chonbuk National University, Iksan 54596, Korea.
authors.forename: Kyeong-Woon
authors.initials: KW
authors.lastname: Jeong
authors.affiliation: Division of Biotechnology and Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Chonbuk National University, Iksan 54596, Korea.
authors.forename: In-Kyoung
authors.initials: IK
authors.lastname: Lee
authors.affiliation: Division of Biotechnology and Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Chonbuk National University, Iksan 54596, Korea.
authors.forename: Bong-Sik
authors.initials: BS
authors.lastname: Yun
keywords: Neuraminidase inhibitor; Phelligridin E; Phelligridin G; Phellinus igniarius