title: Exploring Flow Procedures for Diazonium Formation.
abstract: The synthesis of diazonium salts is historically an important transformation extensively utilized in dye manufacture. However the highly reactive nature of the diazonium functionality has additionally led to the development of many new reactions including several carbon-carbon bond forming processes. It is therefore highly desirable to determine optimum conditions for the formation of diazonium compounds utilizing the latest processing tools such as flow chemistry to take advantage of the increased safety and continuous manufacturing capabilities. Herein we report a series of flow-based procedures to prepare diazonium salts for subsequent in-situ consumption.
authors.affiliation: Department of Chemistry, University of Durham, South Road, Durham DH1 3LE, UK. te.hu@durham.ac.uk.
authors.forename: Te
authors.initials: T
authors.lastname: Hu
authors.affiliation: Department of Chemistry, University of Durham, South Road, Durham DH1 3LE, UK. i.r.baxendale@durham.ac.uk.
authors.forename: Ian R
authors.initials: IR
authors.lastname: Baxendale
authors.affiliation: Department of Chemistry, University of Durham, South Road, Durham DH1 3LE, UK. marcus.baumann@durham.ac.uk.
authors.forename: Marcus
authors.initials: M
authors.lastname: Baumann
mesh_terms: D060326:Chemistry Techniques, Synthetic; D003979:Diazonium Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D060327:Solid-Phase Synthesis Techniques; D013696:Temperature
chemical_list: D003979:Diazonium Compounds
keywords: diazonium salts; flow chemistry; meso reactor; processing; supported reagent