title: Changes of QT Dispersion in Hemodialysis Patients after Administrating Zhigancao Decoction ().
abstract: OBJECTIVE
  To observe the alteration of QT dispersion (QTd) and QTc dispersion (QTcd) in hemodialysis patients after oral administration of Zhigancao Decoction (, Roasted Licorice Decoction, RLD).
  
  
  METHODS
  To investigate the alteration of QTd and QTcd in 68 routine hemodialysis patients before and after hemodialysis with 12-lead electrocardiogram (ECG) after orally administrated RLD for 4 weeks. Blood was also taken for measurement of plasma electrolytes, liver function, renal function, hemoglobin (Hgb) and hematocrit (HCT).
  
  
  RESULTS
  After hemodialysis, QTd and QTcd were prolonged evidently; the difference was significant between before and after hemodialysis (P<0.05). After RLD orally administrated for 4 weeks, QTd and QTcd only slightly increased after dialysis compared with pre-dialysis (P>0.05). The QTd and QTcd of the post-therapy-post-dialysis decreased significantly compared with the pre-therapy-post-dialysis (P<0.05). There were no other significant changes in other variables (post-therapy-pre-dialysis vs. pre-therapy-pre-dialysis, or post-therapy-post-dialysis vs. pre-therapy-post-dialysis;P>0.05). After therapy, the number of patients with supraventricular arrhythmia, occasional ventricular premature beat and multiple ventricular premature beat were decreased from 15 to 4, 10 to 2 and 7 to 1, respectively.
  
  
  CONCLUSIONS
  RLD therapy not only lowered the increased QTd and QTcd after hemodialysis, but also displayed a safety profile.
authors.affiliation: Department of Nephrology, the Affilliated Hospital of Changchun University of Chinese Medicine, Changchun, 130021, China.
authors.forename: Yan-Qing
authors.initials: YQ
authors.lastname: Tong
authors.affiliation: Department of Nephrology, the Affilliated Hospital of Changchun University of Chinese Medicine, Changchun, 130021, China.
authors.forename: Min
authors.initials: M
authors.lastname: Sun
authors.affiliation: Department of Nephrology, the Affilliated Hospital of Changchun University of Chinese Medicine, Changchun, 130021, China.
authors.forename: Chun-Jie
authors.initials: CJ
authors.lastname: Hu
authors.affiliation: Department of Nephrology, the Affilliated Hospital of Changchun University of Chinese Medicine, Changchun, 130021, China. 919479696@qq.com.
authors.forename: Dong-Kai
authors.initials: DK
authors.lastname: Zhao
mesh_terms: D000328:Adult; D000368:Aged; D003710:Demography; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000627:therapeutic use*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis
chemical_list: D004365:Drugs, Chinese Herbal; C526719:zhigancao decoction
keywords: Chinese medicine; QT dispersion; chronic renal failure; hemodialysis; roasted licorice decoction