title: Ouija board: A transcription factor evolved for only one target in steroid hormone biosynthesis in the fruit fly Drosophila melanogaster.
abstract: Transcription factors generally regulate gene expression of multiple targets. In contrast, our recent finding suggests that the zinc finger protein Ouija board controls steroid hormone biosynthesis through specific regulation of only one gene spookier in Drosophila. It sheds light on a specialized but essential factor that evolved for one target.
authors.affiliation: a Life Science Center of Tsukuba Advanced Research Alliance, University of Tsukuba , Tsukuba , Ibaraki , Japan.
authors.forename: Yuko S
authors.initials: YS
authors.lastname: Niwa
authors.affiliation: b Faculty of Life and Environmental Sciences , University of Tsukuba , Tsukuba , Ibaraki , Japan.
authors.forename: Ryusuke
authors.initials: R
authors.lastname: Niwa
mesh_terms: D000818:Animals; D053898:Biosynthetic Pathways; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics* / Q000378:metabolism; D029721:Drosophila Proteins / Q000235:genetics* / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000235:genetics / Q000378:metabolism*; D026461:Ecdysteroids / Q000096:biosynthesis; D005786:Gene Expression Regulation; D007301:Insect Hormones / Q000096:biosynthesis; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D029721:Drosophila Proteins; D026461:Ecdysteroids; D007301:Insect Hormones; C000608019:Ouib protein, Drosophila; D014157:Transcription Factors; D003577:Cytochrome P-450 Enzyme System; C515319:spok protein, Drosophila
keywords: C2H2-type zinc finger protein; Drosophila melanogaster; Ouija board; ecdysone; ecdysteroid; steroid hormone biosynthesis; transcription