title: X-ray deconvolution microscopy.
abstract: Recent advances in single-photon-counting detectors are enabling the development of novel approaches to reach micrometer-scale resolution in x-ray imaging. One example of such a technology are the MEDIPIX3RX-based detectors, such as the LAMBDA which can be operated with a small pixel size in combination with real-time on-chip charge-sharing correction. This characteristic results in a close to ideal, box-like point spread function which we made use of in this study. The proposed method is based on raster-scanning the sample with sub-pixel sized steps in front of the detector. Subsequently, a deconvolution algorithm is employed to compensate for blurring introduced by the overlap of pixels with a well defined point spread function during the raster-scanning. The presented approach utilizes standard laboratory x-ray equipment while we report resolutions close to 10 μm. The achieved resolution is shown to follow the relationship [Formula: see text] with the pixel-size p of the detector and the number of raster-scanning steps n.
authors.affiliation: Lehrstuhl für Biomedizinische Physik, Physik-Department & Institut für Medizintechnik, Technische Universität München, James-Franck-Strasse, 85748 Garching, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Ehn
authors.affiliation: Lehrstuhl für Biomedizinische Physik, Physik-Department & Institut für Medizintechnik, Technische Universität München, James-Franck-Strasse, 85748 Garching, Germany.
authors.forename: Franz Michael
authors.initials: FM
authors.lastname: Epple
authors.affiliation: Lehrstuhl für Biomedizinische Physik, Physik-Department & Institut für Medizintechnik, Technische Universität München, James-Franck-Strasse, 85748 Garching, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Fehringer
authors.affiliation: Deutsches Elektronen-Synchrotron (DESY), Notkestr. 85, 22607 Hamburg, Germany.
authors.forename: David
authors.initials: D
authors.lastname: Pennicard
authors.affiliation: Deutsches Elektronen-Synchrotron (DESY), Notkestr. 85, 22607 Hamburg, Germany; Mid Sweden University, 851 80 Sundsvall, Sweden.
authors.forename: Heinz
authors.initials: H
authors.lastname: Graafsma
authors.affiliation: Lehrstuhl für Biomedizinische Physik, Physik-Department & Institut für Medizintechnik, Technische Universität München, James-Franck-Strasse, 85748 Garching, Germany; Institut für Radiologie, Klinikum rechts der Isar, Technische Universität München, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Noël
authors.affiliation: Lehrstuhl für Biomedizinische Physik, Physik-Department & Institut für Medizintechnik, Technische Universität München, James-Franck-Strasse, 85748 Garching, Germany.
authors.forename: Franz
authors.initials: F
authors.lastname: Pfeiffer
keywords: (040.0040) Detectors; (100.0100) Image processing; (100.6640) Superresolution; (110.6960) Tomography; (170.7440) X-ray imaging; (180.7460) X-ray microscopy