title: Indole Alkaloids from the Leaves of Nauclea officinalis.
abstract: Three new indole alkaloids, named naucleamide G (1), and nauclealomide B and C (5 and 6), were isolated from the n-BuOH-soluble fraction of an EtOH extract of the leaves of Nauclea officinalis, together with three known alkaloids, paratunamide C (2), paratunamide D (3) and paratunamide A (4). The structures with absolute configurations of the new compounds were identified on the basis of 1D and 2D NMR, HRESIMS, acid hydrolysis and quantum chemical circular dichroism (CD) calculation. According to the structures of isolated indole alkaloids, their plausible biosynthetic pathway was deduced.
authors.affiliation: Department of Pharmacy, School of Medicine, Shenzhen University, Shenzhen 518060, China. fanlong_kkk@163.com.
authors.forename: Long
authors.initials: L
authors.lastname: Fan
authors.affiliation: Department of Pharmacy, School of Medicine, Shenzhen University, Shenzhen 518060, China. liaochenghui1990@163.com.
authors.forename: Cheng-Hui
authors.initials: CH
authors.lastname: Liao
authors.affiliation: Department of Pharmacy, School of Medicine, Shenzhen University, Shenzhen 518060, China. kangqiangrong@163.com.
authors.forename: Qiang-Rong
authors.initials: QR
authors.lastname: Kang
authors.affiliation: Department of Pharmacy, School of Medicine, Shenzhen University, Shenzhen 518060, China. y.k.zheng@163.com.
authors.forename: Kai
authors.initials: K
authors.lastname: Zheng
authors.affiliation: Department of Pharmacy, School of Medicine, Shenzhen University, Shenzhen 518060, China. Yingchunjiang313@gmail.com.
authors.forename: Ying-Chun
authors.initials: YC
authors.lastname: Jiang
authors.affiliation: Department of Pharmacy, School of Medicine, Shenzhen University, Shenzhen 518060, China. hezhendan@126.com.
authors.forename: Zhen-Dan
authors.initials: ZD
authors.lastname: He
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D002243:Carbolines / Q000737:chemistry / Q000302:isolation & purification; D002942:Circular Dichroism; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry*; D019666:Rubiaceae / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D002243:Carbolines; D005960:Glucosides; D006027:Glycosides; D010936:Plant Extracts; C000606171:nauclealomide A; C585593:naucleamide G
keywords: Nauclea officinalis; biosynthetic pathway; indole alkaloids