title: Maladaptive Plasticity in Aphasia: Brain Activation Maps Underlying Verb Retrieval Errors.
abstract: Anomia, or impaired word retrieval, is the most widespread symptom of aphasia, an acquired language impairment secondary to brain damage. In the last decades, functional neuroimaging techniques have enabled studying the neural basis underlying anomia and its recovery. The present study aimed to explore maladaptive plasticity in persistent verb anomia, in three male participants with chronic nonfluent aphasia. Brain activation maps associated with semantic verb paraphasia occurring within an oral picture-naming task were identified with an event-related fMRI paradigm. These maps were compared with those obtained in our previous study examining adaptive plasticity (i.e., successful verb naming) in the same participants. The results show that activation patterns related to semantic verb paraphasia and successful verb naming comprise a number of common areas, contributing to both maladaptive and adaptive neuroplasticity mechanisms. This finding suggests that the segregation of brain areas provides only a partial view of the neural basis of verb anomia and successful verb naming. Therefore, it indicates the importance of network approaches which may better capture the complexity of maladaptive and adaptive neuroplasticity mechanisms in anomia recovery.
authors.affiliation: Rijndam Rehabilitation Institute, P.O. Box 23181, 3001 KD Rotterdam, Netherlands; Erasmus MC, University Medical Center Rotterdam, Department of Rehabilitation Medicine, P.O. Box 2040, 3000 CA Rotterdam, Netherlands.
authors.forename: Kerstin
authors.identifier: 0000-0003-1259-2704
authors.initials: K
authors.lastname: Spielmann
authors.affiliation: Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, 4565 Chemin Queen-Mary, Montréal, QC, Canada H3W 1W5.
authors.forename: Edith
authors.initials: E
authors.lastname: Durand
authors.affiliation: École d'Orthophonie et d'Audiologie, Université de Montréal, 7077 Avenue du Parc, Montréal, QC, Canada H3N 1X7.
authors.forename: Karine
authors.initials: K
authors.lastname: Marcotte
authors.affiliation: Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, 4565 Chemin Queen-Mary, Montréal, QC, Canada H3W 1W5; École d'Orthophonie et d'Audiologie, Université de Montréal, 7077 Avenue du Parc, Montréal, QC, Canada H3N 1X7.
authors.forename: Ana Inés
authors.initials: AI
authors.lastname: Ansaldo
mesh_terms: D000368:Aged; D001037:Aphasia / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001921:Brain / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001931:Brain Mapping / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D010775:Photic Stimulation / Q000379:methods; D011597:Psychomotor Performance / Q000502:physiology