title: Clinical Trial of 1000 Subjects Randomized to 5 Low-Volume Bowel Preparations for Colonoscopy and Their Acceptance of Split-Dose Bowel Preparations.
abstract: BACKGROUND
  We assessed the efficacy and tolerability of 5 low-volume bowel preparations for colonoscopy.
  
  
  METHODS
  We performed an investigator-blinded, randomized trial of 5 bowel preparations: 64 ounces of Gatorade and 306 or 357 g of PEG, both given the day prior; Gatorade and 306 g PEG, 2 L PEG-electrolyte solution with ascorbic acid, and sulfate solution, all 3 given as a split dose. One thousand outpatients consumed their preparation before a morning colonoscopy. The primary endpoint was colon cleanliness assessed by the Chicago Bowel Preparation Scale (BPS). Tolerability was assessed using a subject questionnaire. Another primary endpoint was patient acceptance of a split-dose bowel preparation assessed using a subject questionnaire.
  
  
  RESULTS
  No statistically significant differences in the modified Chicago BPS were found among Gatorade and 357 g of PEG given as a day-prior dose and the 3 split-dose arms with 98.5% of colons cleansed adequately. The Gatorade and 357 g of PEG had significantly lower Chicago BPS fluid scores and Chicago BPS total scores (indicating dryer colons that required more irrigation) than the 3 split-dose arms. The Gatorade and PEG preparations were better tolerated. Many subjects are unwilling to consume a split-dose preparation and the majority of subjects would prefer a day-prior preparation with this preference highly dependent on the type of preparation they just consumed.
  
  
  CONCLUSIONS
  The cleanliness of the colons was not significantly different among the 3 split-dose preparations. Day-prior dosing of Gatorade and 357 g of PEG allowed the mucosa to be visualized as well as did the split-dose preparations.
authors.affiliation: Gastroenterology Services Ltd, Downers Grove, IL.
authors.forename: David P
authors.initials: DP
authors.lastname: Gerard
authors.forename: Diane B
authors.initials: DB
authors.lastname: Foster
authors.forename: John L
authors.initials: JL
authors.lastname: Holden
authors.forename: Jieun
authors.initials: J
authors.lastname: Kang
authors.forename: Manfred W
authors.initials: MW
authors.lastname: Raiser
mesh_terms: D000368:Aged; D002400:Cathartics / Q000008:administration & dosage* / Q000009:adverse effects; D003113:Colonoscopy / Q000379:methods*; D004573:Electrolytes / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006801:Humans; D007552:Isotonic Solutions / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D010342:Patient Acceptance of Health Care; D011092:Polyethylene Glycols / Q000008:administration & dosage* / Q000009:adverse effects; D011446:Prospective Studies; D016037:Single-Blind Method; D011795:Surveys and Questionnaires
chemical_list: D002400:Cathartics; D004573:Electrolytes; D007552:Isotonic Solutions; C011259:gatorade; D011092:Polyethylene Glycols