title: Prognostic role of s-phase kinase-associated protein 2 in breast cancer: A meta-analysis.
abstract: OBJECTIVE
  Emerging evidence has shown that the F-box protein S-phase kinase-associated protein 2 (Skp2) plays an important role in the pathogenesis of breast cancer (BC). Our study aimed to evaluate the prognostic value of Skp2 in BC patients using meta-analysis based on the published studies.
  
  
  METHODS
  Eligible studies were identified by searching the online databases such as PubMed, EMBASE, and Web of Science up to October 2015. Hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated to clarify the correlation between Skp2 expression and indicators of BC clinical outcomes, including overall survival (OS), disease-free survival (DFS), and BC-specific survival.
  
  
  RESULTS
  In total, nine studies with 1820 BC patients were included for final analysis. The meta-analysis suggested that Skp2 overexpression was associated with poor OS (HR = 2.58, 95% CI: 1.83-3.63, P = 0.000) and poor DFS (HR = 2.12, 95% CI: 1.48-3.05, P = 0.000) in BC patients.
  
  
  CONCLUSIONS
  This meta-analysis indicates that enhanced Skp2 is an independent prognostic factor for poor cancer survival.
authors.affiliation: Department of Breast thyroid, The Second Hospital of Jilin University, Jilin, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Department of Outpatient, Changchun Obstetrics Gynecology Hospital, Jilin, China.
authors.forename: N
authors.initials: N
authors.lastname: Li
authors.affiliation: Department of General Surgery, The Second Hospital of Jilin University, Jilin, China.
authors.forename: H
authors.initials: H
authors.lastname: Ren
authors.affiliation: Department of Nursing, The Second Hospital of Jilin University, Jilin, China.
authors.forename: X
authors.initials: X
authors.lastname: Guo
authors.affiliation: Department of Orthopedics, The Second Hospital of Jilin University, Jilin, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Rheumatology and Immunology, The First Affiliated Hospital of Jilin University, Jilin, China.
authors.forename: S
authors.initials: S
authors.lastname: Ma
authors.affiliation: Department of Breast, The Second Hospital of Jilin University, China.
authors.forename: D
authors.initials: D
authors.lastname: Wang
mesh_terms: D001943:Breast Neoplasms / Q000201:enzymology*; D005260:Female; D006801:Humans; D011379:Prognosis; D044786:S-Phase Kinase-Associated Proteins / Q000378:metabolism*
chemical_list: D044786:S-Phase Kinase-Associated Proteins