title: Instrumental evaluation of anti-aging effects of cosmetic formulations containing palmitoyl peptides,Silybum marianumseed oil, vitamin E and other functional ingredients on aged human skin.
abstract: Anti-aging cosmetics are widely used for improving signs of aged skin such as skin wrinkles, decreased elasticity, low dermal density and yellow skin tone. The present study evaluated the effects of cosmetic formulations, eye cream and facial cream, containing palmitoyl peptides,Silybum marianum(S. marianum) seed oil, vitamin E and other functional ingredients on the improvement of facial wrinkles, elasticity, dermal density and skin tone after 4 weeks period of application on aged human skin. Healthy volunteers (n=20) with aged skin were recruited to apply the test materials facially twice per day for 4 weeks. Skin wrinkles, elasticity, dermal density and skin tone were measured instrumentally for assessing the improvement of skin aging. All the measurements were conducted prior to the application of test materials and at 2 and 4 weeks of treatment. Crow's feet wrinkles were decreased 5.97% after 2 weeks of test material application and 14.07% after 4 weeks of application in comparison of pre-application. Skin elasticity was increased 6.81% after 2 weeks and 8.79% after 4 weeks. Dermal density was increased 16.74% after 2 weeks and 27.63% after 4 weeks. With the L* value indicating skin brightness and the a* value indicating erythema (redness), the results showed that brightness was increased 1.70% after 2 weeks and 2.14% after 4 weeks, and erythema was decreased 10.45% after 2 weeks and 22.39% after 4 weeks. Hence, the test materials appear to exert some degree of anti-aging effects on aged human skin. There were no abnormal skin responses from the participants during the trial period. We conclude that the facial and eye cream containing palmitoyl peptides andS. marianumseed oil, vitamin E and other ingredients have effects on the improvement of facial wrinkles, elasticity, dermal density and skin tone.
authors.affiliation: Department of Dermatology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, Gyeonggi 116-118, Republic of Korea.
authors.forename: Hyung Jin
authors.initials: HJ
authors.lastname: Hahn
authors.affiliation: Department of Dermatology, Konkuk University School of Medicine, Seoul 143-701, Republic of Korea.
authors.forename: Ho Jung
authors.initials: HJ
authors.lastname: Jung
authors.affiliation: Dr. Med Christine Schrammek Kosmetik GmbH and Co. KG., 45127 Essen, Germany.
authors.forename: Med Christine
authors.initials: MC
authors.lastname: Schrammek-Drusios
authors.affiliation: Department of Cosmetology, Kyung-In Women's University, Incheon 110-810, Republic of Korea.
authors.forename: Sung Nae
authors.initials: SN
authors.lastname: Lee
authors.affiliation: Second Enterprise Research Building, KISCS Incorporated, Chungcheongbuk-do 28156, Republic of Korea.
authors.forename: Ji-Hyun
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Second Enterprise Research Building, KISCS Incorporated, Chungcheongbuk-do 28156, Republic of Korea.
authors.forename: Seung Bin
authors.initials: SB
authors.lastname: Kwon
authors.affiliation: Second Enterprise Research Building, KISCS Incorporated, Chungcheongbuk-do 28156, Republic of Korea.
authors.forename: In-Sook
authors.initials: IS
authors.lastname: An
authors.affiliation: Department of Biological Engineering, Korea Institute for Skin and Clinical Sciences, Konkuk University, Seoul 143-701, Republic of Korea.
authors.forename: Sungkwan
authors.initials: S
authors.lastname: An
authors.affiliation: Department of Dermatology, Konkuk University School of Medicine, Seoul 143-701, Republic of Korea.
authors.forename: Kyu Joong
authors.initials: KJ
authors.lastname: Ahn
keywords: Silybum marianum seed oil; dermal density; elasticity; facial wrinkles; palmitoyl peptides; skin tone