title: Ulcerations due to methotrexate toxicity in a psoriasis patient.
abstract: Methotrexate is one of the most used drugs in the treatment of psoriasis with indication of systemic therapy. Cutaneous and mucous side effects are described by pharmacological characteristics of the drug itself or due to overdose. We report the case of a patient with ulcerations in oral mucosa and psoriatic plaques after incorrect use of Methotrexate. Prescribed in a weekly dose, it was used continuously for 10 days and without simultaneous intake of folic acid. It is important to ensure correct comprehension of the prescription.
authors.affiliation: Instituto de Dermatologia Professor Rubem David Azulay da Santa Casa da Misericórdia do Rio de Janeiro (IDPRDA/SCMRJ) - Rio de Janeiro (RJ), Brazil.
authors.forename: Claudia Fernanda Dias
authors.initials: CF
authors.lastname: Souza
authors.affiliation: Instituto de Dermatologia Professor Rubem David Azulay da Santa Casa da Misericórdia do Rio de Janeiro (IDPRDA/SCMRJ) - Rio de Janeiro (RJ), Brazil.
authors.forename: Olga Milena Zarco
authors.initials: OM
authors.lastname: Suarez
authors.affiliation: Instituto de Dermatologia Professor Rubem David Azulay da Santa Casa da Misericórdia do Rio de Janeiro (IDPRDA/SCMRJ) - Rio de Janeiro (RJ), Brazil.
authors.forename: Talita Fonseca Medeiros da
authors.initials: TF
authors.lastname: Silva
authors.affiliation: Instituto de Dermatologia Professor Rubem David Azulay da Santa Casa da Misericórdia do Rio de Janeiro (IDPRDA/SCMRJ) - Rio de Janeiro (RJ), Brazil.
authors.forename: Ana Carolina Lourenço Araújo
authors.initials: AC
authors.lastname: Gorenstein
authors.affiliation: Instituto de Dermatologia Professor Rubem David Azulay da Santa Casa da Misericórdia do Rio de Janeiro (IDPRDA/SCMRJ) - Rio de Janeiro (RJ), Brazil.|Fundação Oswaldo Cruz (FIOCRUZ) - Rio de Janeiro (RJ), Brazil.
authors.forename: Leonardo Pereira
authors.initials: LP
authors.lastname: Quintella
authors.affiliation: Instituto de Dermatologia Professor Rubem David Azulay da Santa Casa da Misericórdia do Rio de Janeiro (IDPRDA/SCMRJ) - Rio de Janeiro (RJ), Brazil.
authors.forename: João Carlos Regazzi
authors.initials: JC
authors.lastname: Avelleira
mesh_terms: D000284:Administration, Oral; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D005260:Female; D005493:Folic Acid Antagonists / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007970:Leukopenia / Q000139:chemically induced; D008508:Medication Errors / Q000009:adverse effects; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged; D019226:Oral Ulcer / Q000139:chemically induced* / Q000473:pathology; D000067490:Prescription Drug Overuse / Q000009:adverse effects; D011565:Psoriasis / Q000188:drug therapy; D012883:Skin Ulcer / Q000139:chemically induced* / Q000473:pathology
chemical_list: D005493:Folic Acid Antagonists; D008727:Methotrexate