title: The Successful Treatment of Calciphylaxis with Sodium Thiosulfate and Hyperbaric Oxygen in a Non-dialyzed Patient with Chronic Kidney Disease.
abstract: We present the case of a non-dialyzed patient with chronic kidney disease and biopsy-proven calciphylaxis who presented with painful cutaneous ulcers on both legs. The skin ulcers drastically improved within 6 months after the initiation of hemodialysis, aggressive wound care, the control of a mineral and bone disorder, and the administration of sodium thiosulfate and hyperbaric oxygen therapy. Notably, the patient's serum levels of C-reactive protein and calciprotein particles decreased and her serum albumin and fetuin-A levels increased in parallel with the alleviation of her calciphylaxis. This case highlights the importance of applying combined medical treatment to calciphylaxis and suggests the possible involvement of calciprotein particles in the pathogenesis of calciphylaxis.
authors.affiliation: Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Japan.
authors.forename: Seishi
authors.initials: S
authors.lastname: Aihara
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Yamada
authors.forename: Yushi
authors.initials: Y
authors.lastname: Uchida
authors.forename: Hokuto
authors.initials: H
authors.lastname: Arase
authors.forename: Akihiro
authors.initials: A
authors.lastname: Tsuchimoto
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Nakano
authors.forename: Masatomo
authors.initials: M
authors.lastname: Taniguchi
authors.forename: Harumichi
authors.initials: H
authors.lastname: Higashi
authors.forename: Takanari
authors.initials: T
authors.lastname: Kitazono
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Tsuruya
mesh_terms: D002097:C-Reactive Protein; D002115:Calciphylaxis / Q000150:complications* / Q000628:therapy*; D005260:Female; D006801:Humans; D006931:Hyperbaric Oxygenation / Q000379:methods*; D008875:Middle Aged; D006435:Renal Dialysis / Q000379:methods; D051436:Renal Insufficiency, Chronic / Q000150:complications*; D012709:Serum Albumin / Q000032:analysis; D012883:Skin Ulcer / Q000628:therapy; D013885:Thiosulfates / Q000627:therapeutic use*; D060749:alpha-2-HS-Glycoprotein / Q000032:analysis
chemical_list: D012709:Serum Albumin; D013885:Thiosulfates; D060749:alpha-2-HS-Glycoprotein; D002097:C-Reactive Protein; C017717:sodium thiosulfate