title: A new method for noninvasive venous blood oxygen detection.
abstract: BACKGROUND
  Blood oxygen saturation of vein (SvO2) is an important clinical parameter for patient monitoring. However, the existing clinical methods are invasive, expensive, which are also painful for patients.
  
  
  METHODS
  Based on light-absorption, this study describes a new noninvasive SvO2 measurement method by using external stimulation signal to generate cyclical fluctuation signal in the vein, which overcomes the low signal-to-noise ratio problem in the measurement process. In this way, the value of SvO2 can be obtained continuously in real time.
  
  
  RESULTS
  The experimental results demonstrate that the method can successfully measure venous oxygen saturation by artificial addition of stimulation. Under hypoxic conditions, the system can reflect the overall decline of venous oxygen saturation better. When the results measured by the new method are compared with those measured by the invasive method, the root mean square error of the difference is 5.31 and the correlation coefficient of the difference is 0.72. The new method can be used to measure SvO2 and evaluate body oxygen consumption, and its accuracy needs improvement.
  
  
  CONCLUSIONS
  Real-time and continuous monitoring can be achieved by replacing invasive method with noninvasive method, which provides more comprehensive clinical information in a timely manner and better meet the needs of clinical treatment. However, the accuracy of the new noninvasive SvO2 measurement based on light-absorption has to be further improved.
authors.affiliation: School of Medicine, Shenzhen University, Shenzhen, China.|National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Shenzhen, China.|Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Shenzhen, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Zhang
authors.affiliation: School of Medicine, Shenzhen University, Shenzhen, China.|National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Shenzhen, China.|Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Shenzhen, China.
authors.forename: Meimei
authors.initials: M
authors.lastname: Zhang
authors.affiliation: School of Medicine, Shenzhen University, Shenzhen, China.|National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Shenzhen, China.|Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Shenzhen, China.
authors.forename: Shengkun
authors.initials: S
authors.lastname: Zheng
authors.affiliation: School of Medicine, Shenzhen University, Shenzhen, China.|National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Shenzhen, China.|Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Shenzhen, China.
authors.forename: Liqi
authors.initials: L
authors.lastname: Wang
authors.affiliation: School of Medicine, Shenzhen University, Shenzhen, China. yejilun@126.com.|National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Shenzhen, China. yejilun@126.com.|Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Shenzhen, China. yejilun@126.com.
authors.forename: Jilun
authors.initials: J
authors.lastname: Ye
mesh_terms: D001158:Arteries; D001784:Blood Gas Analysis / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D008991:Monitoring, Physiologic / Q000295:instrumentation / Q000379:methods*; D010100:Oxygen / Q000097:blood*; D012815:Signal Processing, Computer-Assisted; D014680:Veins
chemical_list: D010100:Oxygen
keywords: External stimulation signal; Noninvasive method; SvO2