title: Natural Course of Metabolically Healthy Overweight/Obese Subjects and the Impact of Weight Change.
abstract: Few studies have described the characteristics of metabolically healthy individuals with excess fat in the Chinese population. This study aimed to prospectively investigate the natural course of metabolically healthy overweight/obese (MH-OW/OB) adults, and to assess the impact of weight change on developing metabolic abnormalities. During 2009-2010, 525 subjects without any metabolic abnormalities or other obesity-related diseases were evaluated and reevaluated after 5 years. The subjects were categorized into two groups of overweight/obese and normal weight based on the criteria of BMI by 24.0 at baseline. At follow-up, the MH-OW/OB subjects had a significantly increased risk of developing metabolically abnormalities compared with metabolically healthy normal-weight (MH-NW) individuals (risk ratio: 1.35, 95% confidence interval: 1.17-1.49, p value < 0.001). In the groups of weight gain and weight maintenance, the MH-OW/OB subjects was associated with a larger increase in fasting glucose, triglycerides, systolic blood pressure, diastolic blood pressure and decrease in high-density lipoprotein cholesterol comparing with MH-NW subjects. In the weight loss group, no significant difference of changes of metabolic parameters was observed between MH-OW/OB and MH-NW adults. This study verifies that MH-OW/OB are different from MH-NW subjects. Weight management is needed for all individuals since weight change has a significant effect on metabolic health without considering the impact of weight change according to weight status.
authors.affiliation: Department of Epidemiology &amp; Biostatistics, School of Public Health, Zhejiang University, Hangzhou 310058, Zhejiang, China. canprezrz@126.com.
authors.forename: Ruizhi
authors.initials: R
authors.lastname: Zheng
authors.affiliation: Department of Endocrinology and Institute of Cardiovascular Diseases, Zhejiang Putuo Hospital, Zhoushan 316100, Zhejiang, China. Prylcg@mail.zsptt.zj.cn.
authors.forename: Chengguo
authors.initials: C
authors.lastname: Liu
authors.affiliation: Tongxiang Center for Disease Control and Prevention, Tongxiang 314500, Zhejiang, China. chunmei328@sina.com.
authors.forename: Chunmei
authors.initials: C
authors.lastname: Wang
authors.affiliation: Institute of Nutrition and Food Safety, Zhejiang Center for Disease Control and Prevention, Hangzhou 310000, Zhejiang, China. bzhou@cdc.zj.cn.
authors.forename: Biao
authors.initials: B
authors.lastname: Zhou
authors.affiliation: Department of Epidemiology &amp; Biostatistics, School of Public Health, Zhejiang University, Hangzhou 310058, Zhejiang, China. lyzju_2012@163.com.
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Epidemiology &amp; Biostatistics, School of Public Health, Zhejiang University, Hangzhou 310058, Zhejiang, China. pfx19911119@163.com.
authors.forename: Feixia
authors.initials: F
authors.lastname: Pan
authors.affiliation: Institute of Nutrition and Food Safety, Zhejiang Center for Disease Control and Prevention, Hangzhou 310000, Zhejiang, China. rhzhang@cdc.zj.cn.
authors.forename: Ronghua
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology &amp; Biostatistics, School of Public Health, Zhejiang University, Hangzhou 310058, Zhejiang, China. zhuym@zju.edu.cn.
authors.forename: Yimin
authors.initials: Y
authors.lastname: Zhu
mesh_terms: D000368:Aged; D015992:Body Mass Index; D000068959:Body Weight Maintenance; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006291:Health Policy; D019456:Health Transition; D006801:Humans; D015994:Incidence; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000208:ethnology / Q000209:etiology* / Q000517:prevention & control; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology / Q000208:ethnology / Q000209:etiology* / Q000517:prevention & control; D000067329:Obesity, Metabolically Benign / Q000208:ethnology / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy; D050177:Overweight / Q000208:ethnology / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy; D011446:Prospective Studies; D012307:Risk Factors; D057566:Self Report; D015430:Weight Gain / Q000208:ethnology; D015431:Weight Loss / Q000208:ethnology
keywords: metabolically healthy; overweight and obese; weight change