title: Life Course Socioeconomic Position and Subclinical Disease: The Jackson Heart Study.
abstract: African Americans experience higher rates of cardiovascular disease (CVD) and lower childhood and adult socioeconomic position (SEP). Research that examines the associations of multiple measures of SEP with subclinical CVD markers among African Americans is limited.
  
  
  
  Data from the Jackson Heart Study (JHS) were used to examine cross-sectional associations of childhood SEP and adult SEP with subclinical markers among 4,756 African American participants (mean age 54, 64% female), adjusting for age, health behaviors and CVD risk factors. Subclinical markers included prevalent left ventricular hypertrophy (LVH), peripheral artery disease (PAD), coronary artery calcification (CAC), and carotid intima-media thickness (CIMT).
  
  
  
  The prevalence of LVH, PAD and CAC was 7%, 6% and 45%, respectively. The mean CIMT was .72 ± .17 mm. In fully-adjusted models, having a college education was inversely associated with PAD (OR, .27; 95% CI .13,.56) and CIMT (β=-29.7, P<.01). Income was inversely associated with LVH after adjustment for health behaviors (OR, .49 95% CI .25,.96), though associations attenuated in the fully-adjusted model. Measures of childhood SEP (material resources and mother's education) were not consistently associated with subclinical disease measures other than a positive association between material resources and CIMT.
  
  
  
  Subclinical disease markers were patterned by adult SEP measures among African Americans.
authors.affiliation: University of Mississippi Medical Center School of Medicine; Center of Biostatistics and Bioinformatics, University of Mississippi Medical Center School of Medicine.
authors.forename: Bradley
authors.initials: B
authors.lastname: Deere
authors.affiliation: Center of Biostatistics and Bioinformatics, University of Mississippi Medical Center School of Medicine; Department of Medicine, University of Mississippi Medical Center School of Medicine; Jackson Heart Study, Coordinating Center.
authors.forename: Michael
authors.initials: M
authors.lastname: Griswold
authors.affiliation: Center of Biostatistics and Bioinformatics, University of Mississippi Medical Center School of Medicine.
authors.forename: Seth
authors.initials: S
authors.lastname: Lirette
authors.affiliation: Department of Medicine, University of Mississippi Medical Center School of Medicine; Jackson Heart Study, Coordinating Center.
authors.forename: Ervin
authors.initials: E
authors.lastname: Fox
authors.affiliation: Department of Medicine, University of Mississippi Medical Center School of Medicine; Jackson Heart Study, Coordinating Center.
authors.forename: Mario
authors.initials: M
authors.lastname: Sims
mesh_terms: D000328:Adult; D001741:Black or African American / Q000706:statistics & numerical data*; D000368:Aged; D015415:Biomarkers; D002318:Cardiovascular Diseases / Q000191:economics / Q000208:ethnology*; D059168:Carotid Intima-Media Thickness; D003324:Coronary Artery Disease; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D012923:Social Class
chemical_list: D015415:Biomarkers
keywords: African American; Socioeconomic Position; Subclinical Cardiovascular Disease