title: [THE STUDY OF THE EFFECTS OF ANXYOLYTIC, ANTIOXIDANT, IMMUNOCORRECTOR AND HYPERBARIC OXYGENATION ON THE DYNAMICS OF MAIN BLOOD GAS AND ELECTROLYTE INDICES AND BEHAVIORAL RESPONSE IN EXPERIMENTAL STRESS MODEL].
abstract: Experiments on the model of immobilization stress in albino mice showed that a combination of mexidol, thymogen, and hyperbaric oxygenation reduced adverse effects of diazepam on behavioral response of animals in the black-and-white chamber and elevated cross maze tests and led to optimization of the blood gas composition as manifested by increased oxygen tension, normalization of the partial pressure of carbon dioxide, and restoration of the acid-base balance and blood bicarbonate level. The proposed combined treatment can be recommended for the treatment of patients with stress-induced pathology.
authors.forename: E V
authors.initials: EV
authors.lastname: Govsh
authors.forename: V G
authors.initials: VG
authors.lastname: Podsevatkin
authors.forename: D S
authors.initials: DS
authors.lastname: Blinov
authors.forename: S V
authors.initials: SV
authors.lastname: Kiryukhina
authors.forename: S V
authors.initials: SV
authors.lastname: Podsevatkina
authors.forename: N V
authors.initials: NV
authors.lastname: Bochkareva
mesh_terms: D000136:Acid-Base Equilibrium; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001784:Blood Gas Analysis; D002245:Carbon Dioxide / Q000097:blood; D003975:Diazepam / Q000009:adverse effects / Q000037:antagonists & inhibitors; D004151:Dipeptides / Q000494:pharmacology*; D005260:Female; D006931:Hyperbaric Oxygenation; D007103:Immobilization; D007155:Immunologic Factors / Q000494:pharmacology*; D008297:Male; D051379:Mice; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D010847:Picolines / Q000494:pharmacology*; D013315:Stress, Psychological / Q000097:blood / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*
chemical_list: D014151:Anti-Anxiety Agents; D000975:Antioxidants; D004151:Dipeptides; D007155:Immunologic Factors; D010847:Picolines; C060736:thymogen; D002245:Carbon Dioxide; C070020:emoxypine succinate; D003975:Diazepam; D010100:Oxygen