title: Meta-analysis of cyclooxygenase-2 (COX-2) 765G>C polymorphism and Alzheimer's disease.
abstract: The cyclooxygenase-2 (COX-2) 765G>C polymorphism has been extensively investigated for association with Alzheimer's disease (AD). However, results of different studies have been inconsistent. The aim of the present meta-analysis was to evaluate the association between the 765G>C polymorphism of the COX-2 gene and susceptibility to AD. We searched all related subjects in PubMed, Embase, SinoMed, and China Knowledge Resource Integrated Database and identified seven studies that reported a relationship between the COX-2 765G>C polymorphism and AD. A total of 1260 cases and 1112 controls were included in the seven studies. Our data suggest that the COX-2 765G>C polymorphism may decrease the risk of AD in five genetic models. As a result, this meta-analysis suggests the 765G>C polymorphism of the COX-2 gene may be a protective factor for AD. As our sample size was limited, large-scale, well-designed studies are necessary to validate the association between the COX-2 765G>C polymorphism and AD.
authors.affiliation: Department of Neurology, The Jintan Hospital Affiliated to Jiangsu University, Changzhou 213200, China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Su
authors.affiliation: Department of Cerebral Surgery, Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital, Changzhou 213003, China.
authors.forename: Shihong
authors.initials: S
authors.lastname: Wen
authors.affiliation: Nanjing Medical University, Nanjing 210029, China.
authors.forename: Jinlong
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Department of Orthopaedic Trauma, Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital, Changzhou 213003, China; Central Laboratory, Changzhou Second People's Hospital, Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China. Electronic address: lrp216@sina.com.
authors.forename: Ruiping
authors.initials: R
authors.lastname: Liu
authors.affiliation: Department of Cerebral Surgery, Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital, Changzhou 213003, China.
authors.forename: Jinsong
authors.initials: J
authors.lastname: Yang
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics*; D051546:Cyclooxygenase 2 / Q000235:genetics*; D006801:Humans
chemical_list: D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human
keywords: 765G>C; Alzheimer’s disease; Cyclooxygenase-2; Meta-analysis; Polymorphism