title: Association between single nucleotide polymorphisms in the TSPYL6 gene and breast cancer susceptibility in the Han Chinese population.
abstract: We investigated the associations between single nucleotide polymorphisms (SNPs) in the testis-specific Y-encoded-like protein 6 (TSPYL6) gene and breast cancer (BC) susceptibility in the Han Chinese population. A total of 183 BC patients and 195 healthy women were included in the study. Six SNPs in TSPYL6 were genotyped and the association with BC risk analyzed. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using unconditional logistic regression analysis. Multivariate logistic regression analysis was used to identify SNPs that correlated with BC susceptibility. Rs11896604 was associated with a decreased risk of BC based on dominant and genotype models. Rs843706 was associated with an increased risk of BC based on a recessive model. Rs11125529 was associated with decreased BC susceptibility based on a genotype model. Finally, rs843711 inversely correlated with clinical stage III/IV BC. Our findings reveal a significant association between SNPs in the TSPYL6 gene and BC risk in a Han Chinese population.
authors.affiliation: School of Life Sciences, Northwest University, Xi'an 710069, China.|National Engineering Research Center for Miniaturized Detection Systems, Xi'an 710069, China.|Department of Obstetrics and Gynecology, Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710004, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
authors.affiliation: School of Life Sciences, Northwest University, Xi'an 710069, China.|National Engineering Research Center for Miniaturized Detection Systems, Xi'an 710069, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.affiliation: Inner Mongolia Medical University, Inner Mongolia, Hohhot 010050, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Guo
authors.affiliation: School of Life Sciences, Northwest University, Xi'an 710069, China.|National Engineering Research Center for Miniaturized Detection Systems, Xi'an 710069, China.
authors.forename: Xiyang
authors.initials: X
authors.lastname: Zhang
authors.affiliation: School of Life Sciences, Northwest University, Xi'an 710069, China.|National Engineering Research Center for Miniaturized Detection Systems, Xi'an 710069, China.
authors.forename: Zhengshuai
authors.initials: Z
authors.lastname: Chen
authors.affiliation: School of Life Sciences, Northwest University, Xi'an 710069, China.|National Engineering Research Center for Miniaturized Detection Systems, Xi'an 710069, China.
authors.forename: Jingjie
authors.initials: J
authors.lastname: Li
authors.affiliation: School of Life Sciences, Northwest University, Xi'an 710069, China.|National Engineering Research Center for Miniaturized Detection Systems, Xi'an 710069, China.
authors.forename: Mengdan
authors.initials: M
authors.lastname: Yan
authors.affiliation: School of Life Sciences, Northwest University, Xi'an 710069, China.|National Engineering Research Center for Miniaturized Detection Systems, Xi'an 710069, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
authors.affiliation: School of Life Sciences, Northwest University, Xi'an 710069, China.|National Engineering Research Center for Miniaturized Detection Systems, Xi'an 710069, China.
authors.forename: Tianbo
authors.initials: T
authors.lastname: Jin
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D001943:Breast Neoplasms / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D020641:Polymorphism, Single Nucleotide
keywords: TSPYL6; association study; breast cancer; single nucleotide polymorphism