title: Polymeric prodrug-functionalized polypropylene films for sustained release of salicylic acid.
abstract: Medical devices decorated with salicylic acid-based polymer chains (polymeric prodrug) that slowly release this anti-inflammatory and anti-biofilm drug at the implantation site were designed. A "grafting from" method was implemented to directly grow chains of a polymerizable derivative of salicylic acid (2-methacryloyloxy-benzoic acid, 2MBA) onto polypropylene (PP). PP was modified both at bulk and on the surface with poly(2MBA) by means of an oxidative pre-irradiation method ((60)Co source), in order to obtain a grafted polymer in which salicylic acid units were linked by means of labile ester bonds. The grafting percent depended on absorbed dose, reaction time, temperature and monomer concentration. The functionalized films were analyzed regarding structure (FTIR-ATR, SEM-EDX, fluorescence microscopy), temperature stability (TGA), interaction with aqueous medium (water contact angle and swelling), pH-responsive release and cytocompatibility (fibroblasts). In the obtained poly(2MBA)-grafted biomaterial, poly(2MBA) behaved as a polymeric prodrug that regulates salicylic acid release once in contact with aqueous medium, showing pH-dependent release rate.
authors.affiliation: Universidad Autónoma de Baja California, Calzada Universidad 14418, Parque Industrial Internacional Tijuana, 22390 Tijuana, Baja California, Mexico.
authors.forename: Hector
authors.initials: H
authors.lastname: Magaña
authors.affiliation: Universidad Autónoma de Baja California, Calzada Universidad 14418, Parque Industrial Internacional Tijuana, 22390 Tijuana, Baja California, Mexico.
authors.forename: Kenia
authors.initials: K
authors.lastname: Palomino
authors.affiliation: Universidad Autónoma de Baja California, Calzada Universidad 14418, Parque Industrial Internacional Tijuana, 22390 Tijuana, Baja California, Mexico. Electronic address: jmcornejo@uabc.edu.mx.
authors.forename: Jose M
authors.initials: JM
authors.lastname: Cornejo-Bravo
authors.affiliation: Departamento de Farmacia y Tecnología Farmacéutica, R+DPharma Group (GI-1645), Facultad de Farmacia, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Díaz-Gómez
authors.affiliation: Departamento de Farmacia y Tecnología Farmacéutica, R+DPharma Group (GI-1645), Facultad de Farmacia, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
authors.forename: Angel
authors.initials: A
authors.lastname: Concheiro
authors.affiliation: Departamento de Química de Radiaciones y Radioquímica, Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, México DF 04510, Mexico.
authors.forename: Edgar
authors.initials: E
authors.lastname: Zavala-Lagunes
authors.affiliation: Departamento de Farmacia y Tecnología Farmacéutica, R+DPharma Group (GI-1645), Facultad de Farmacia, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain. Electronic address: carmen.alvarez.lorenzo@usc.es.
authors.forename: Carmen
authors.initials: C
authors.lastname: Alvarez-Lorenzo
authors.affiliation: Departamento de Química de Radiaciones y Radioquímica, Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, México DF 04510, Mexico. Electronic address: ebucio@nucleares.unam.mx.
authors.forename: Emilio
authors.initials: E
authors.lastname: Bucio
mesh_terms: D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics; D065546:Drug Liberation; D011108:Polymers / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D011126:Polypropylenes / Q000737:chemistry* / Q000493:pharmacokinetics; D011355:Prodrugs / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D020156:Salicylic Acid / Q000737:chemistry* / Q000493:pharmacokinetics
chemical_list: D003692:Delayed-Action Preparations; D011108:Polymers; D011126:Polypropylenes; D011355:Prodrugs; D020156:Salicylic Acid
keywords: Grafting; Polymer-drug conjugate; Polypropylene; Salicylic acid release; pH-dependent release; γ-irradiation