title: Optimal architecture of differentiation cascades with asymmetric and symmetric stem cell division.
abstract: The role of symmetric division in stem cell biology is ambiguous. It is necessary after injuries, but if symmetric divisions occur too often, the appearance of tumours is more likely. To explore the role of symmetric and asymmetric division in cell populations, we propose a mathematical model of competition of populations, in which the stem cell expansion is controlled by fully differentiated cells. We show that there is an optimal fraction of symmetric stem cell division, which maximises the long-term survival probability of the organism. Moreover, we show the optimal number of stem cells in a tissue, and we show that number has to be small enough to reduce the probability of the appearance of advantageous malignant cells, and large enough to assure that the population will not be suppressed by stochastic fluctuations.
authors.affiliation: Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Canada K1H 8L6. Electronic address: dsancheztaltavull@ohri.ca.
authors.forename: Daniel
authors.initials: D
authors.lastname: Sánchez-Taltavull
mesh_terms: D000818:Animals; D060049:Asymmetric Cell Division; D002452:Cell Count; D002454:Cell Differentiation; D002469:Cell Separation; D002470:Cell Survival; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D009154:Mutation / Q000235:genetics; D013234:Stem Cells / Q000166:cytology*; D013269:Stochastic Processes
keywords: (A)Symmetric division; Optimal architecture; Stem cells; Stochastic model