title: Clinical Profile of Patients with Tubercular Subretinal Abscess in a Tertiary Eye Care Center in Southern India.
abstract: OBJECTIVE
  To retrospectively analyze clinical features, laboratory investigations, treatment and visual outcomes in patients with tubercular subretinal abscess.
  
  
  METHODS
  A total of 12 eyes of 12 patients receiving a diagnosis of subretinal abscess, between 2004 and 2014, were included for this retrospective study.
  
  
  RESULTS
  The mean age of the presentation was 29.75 ± 16.72 years (range: 14-62 years) and seven (58.3%) were male. The most common anterior segment presentation was anterior uveitis (75%). The mean BCVA at presentation was 1.62 (in logMAR). A tuberculin skin test was positive in seven patients (58.3%) and five patients had a history of pulmonary tuberculosis. Polymerase chain reaction for the Mycobacterium tuberculosis genome was positive in 6 of 11 eyes from aqueous aspirate (54%) and 4 of 7 eyes from vitreous aspirates (57.14%). All patients were started on systemic steroids and an anti-tubercular regimen. The mean duration of follow-up was 134.28 days. The mean BCVA at final presentation was 1.19 (in logMAR). Chorioretinal scar was the most common finding after resolution.
  
  
  CONCLUSIONS
  Subretinal abscess is a rare manifestation of ocular tuberculosis. A high degree of suspicion and timely management of the condition can prevent loss of vision.
authors.affiliation: a Medical and Vision Research Foundations, Sankara Nethralaya , Sankara Nethralaya , Chennai , Tamil Nadu , India.
authors.forename: Parthopratim
authors.initials: P
authors.lastname: Dutta Majumder
authors.affiliation: a Medical and Vision Research Foundations, Sankara Nethralaya , Sankara Nethralaya , Chennai , Tamil Nadu , India.
authors.forename: Jyotirmay
authors.initials: J
authors.lastname: Biswas
authors.affiliation: a Medical and Vision Research Foundations, Sankara Nethralaya , Sankara Nethralaya , Chennai , Tamil Nadu , India.
authors.forename: Nishat
authors.initials: N
authors.lastname: Bansal
authors.affiliation: a Medical and Vision Research Foundations, Sankara Nethralaya , Sankara Nethralaya , Chennai , Tamil Nadu , India.
authors.forename: Avirupa
authors.initials: A
authors.lastname: Ghose
authors.affiliation: a Medical and Vision Research Foundations, Sankara Nethralaya , Sankara Nethralaya , Chennai , Tamil Nadu , India.
authors.forename: Hitesh
authors.initials: H
authors.lastname: Sharma
mesh_terms: D000038:Abscess / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D000293:Adolescent; D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D001082:Aqueous Humor / Q000382:microbiology; D004269:DNA, Bacterial / Q000235:genetics; D005260:Female; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000302:isolation & purification; D016133:Polymerase Chain Reaction; D012164:Retinal Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D012189:Retrospective Studies; D062606:Tertiary Care Centers; D014374:Tuberculin Test; D014392:Tuberculosis, Ocular / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D014606:Uveitis, Anterior / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D014822:Vitreous Body / Q000382:microbiology; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents; D004269:DNA, Bacterial
keywords: Anti-tubercular therapy; Mycobacterium tuberculosis; choroidal granuloma; ocular tuberculosis; subretinal abscess