title: Family history of cardiovascular disease and non-HDL cholesterol in prepubescent non-obese children.
abstract: OBJECTIVE
  To describe the values of non-HDL cholesterol (NHDL-c) and the frequency of a family history of early cardiovascular disease (family HCVD) in healthy prepubescent children. Analyze the association between NHDL-c and family HCVD, and possible associations with other risk factors for cardiovascular disease (CVD).
  
  
  METHODS
  Cross-sectional study including 269 prepubescent (aged 6-10 years) schoolchildren with a normal body mass index (+1SD<BMI>-2SD).
  
  
  METHODS
  Family HCVD; weight and height, waist circumference and systemic blood pressure; lipid profile (total cholesterol TC, HDL-c, triglycerides and LDL-c), NHDL-c calculation (CT-HDL-c, cut-off = 145 mg/dL) and insulin resistance (HOMA-IR).
  
  
  RESULTS
  High levels were found for NHDL-c in 10 (3.7%) of these schoolchildren, and family early HCVD was found in 46 (17.1%) of them. There was a weak association between family HCVD and NHDL-c (Cramer's-V-test = 0.120; p=0.050). Among the children with NHDL-c≥145 mg/dL, 4 (40%) have family HCVD. The presence of family HCVD was not associated with the variables being studied. The variables independently associated with NHDL-c ≥ 145 mg/dL were: HOMA-IR (OR=1.7; 95CI 1.1-2.6) and diastolic blood pressure (OR=1.1; 95CI 1.02-1.2).
  
  
  CONCLUSIONS
  NHDL-c values were associated with blood pressure and insulin resistance. Family HCVD was not associated with other classic risk factors for CVD, even though the frequency found was five times higher than that of high NHDL-c.
authors.affiliation: PhD - Adjunct Professor, Department of Pediatrics, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brazil.
authors.forename: Maria Wany Louzada
authors.initials: MW
authors.lastname: Strufaldi
authors.affiliation: PhD - Adjunct Professor, Department of Pediatrics, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brazil.|PhD - Professor, Department of Pediatrics, Faculdade de Medicina do ABC (FMABC), Santo André, SP, Brazil.
authors.forename: Fabíola Isabel Suano de
authors.initials: FI
authors.lastname: Souza
authors.affiliation: PhD - Full Professor, Department of Pediatrics, Escola Paulista de Medicina, Unifesp, São Paulo, SP, Brazil.
authors.forename: Rosana Fiorini
authors.initials: RF
authors.lastname: Puccini
authors.affiliation: PhD - Adjunct Professor, Department of Physiology, Escola Paulista de Medicina, Unifesp, São Paulo, SP, Brazil.
authors.forename: Maria do Carmo Pinho
authors.initials: Mdo C
authors.lastname: Franco
mesh_terms: D002318:Cardiovascular Diseases / Q000097:blood / Q000235:genetics* / Q000517:prevention & control*; D002648:Child; D008076:Cholesterol, HDL / Q000097:blood / Q000235:genetics*; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000097:blood / Q000235:genetics* / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008297:Male; D012307:Risk Factors; D055105:Waist Circumference
chemical_list: D008076:Cholesterol, HDL