title: Life-Course Socioeconomic Position and Hippocampal Atrophy in a Prospective Cohort of Older Adults.
abstract: Low socioeconomic position (SEP) has been linked to an increased risk of dementia and cognitive decline. However, little is known about the association between SEP and morphologic brain changes in older age. This study examines the relationships between indicators of life-course SEP with both hippocampal volume (HcV) and HcV loss in a population-based cohort of 1328 older adults aged 65 to 80 years.
  
  
  
  Multivariable linear regression models were used to estimate the associations of SEP with baseline HcV and the annual rate of HcV atrophy according to three life-course conceptual models: the sensitive/critical periods model (which explored SEP in specific periods: in childhood [using parental education], early adulthood [based on participants' education], and midlife [based on participants' socioprofessional group]); the accumulation-of-risk model (life-course cumulative SEP), and the social mobility model (life-course SEP trajectories).
  
  
  
  Participants with lower midlife SEP had smaller HcV (-0.08 cm; 95% confidence interval, -0.15 to -0.01) and 0.17% (95% confidence interval, 0.04%-0.30%) faster hippocampal atrophy than participants with higher midlife SEP. Childhood and early adulthood SEPs were not related to hippocampal measures. The accumulation-of-risk and the social mobility models revealed that the accumulation of socioeconomic disadvantage and declining socioeconomic trajectories were related to faster hippocampal atrophy.
  
  
  
  In this cohort of older adults, lower socioprofessional attainment in midlife and disadvantageous life-course socioeconomic position were associated with faster hippocampal atrophy, a cerebral change linked to cognitive disorders. Results support the hypothesized links between socioenvironmental exposures related to stress and/or cognitive enrichment and brain/cognitive reserve capacities.
authors.affiliation: From the Department of Epidemiology, Biostatistics, and Occupational Health (Elbejjani, Fuhrer, Abrahamowicz), McGill University, Montreal, Quebec, Canada; CNRS (Mazoyer, Crivello), GIN UMR5296, Bordeaux, France; CEA (Mazoyer, Crivello), GIN UMR5296, Bordeaux, France; University of Bordeaux (Mazoyer, Crivello, Tzourio, Dufouil), Bordeaux, France; and INSERM U897 and CIC-1401 (Tzourio, Dufouil), Bordeaux School of Public Health, Bordeaux, France.
authors.forename: Martine
authors.initials: M
authors.lastname: Elbejjani
authors.forename: Rebecca
authors.initials: R
authors.lastname: Fuhrer
authors.forename: Michal
authors.initials: M
authors.lastname: Abrahamowicz
authors.forename: Bernard
authors.initials: B
authors.lastname: Mazoyer
authors.forename: Fabrice
authors.initials: F
authors.lastname: Crivello
authors.forename: Christophe
authors.initials: C
authors.lastname: Tzourio
authors.forename: Carole
authors.initials: C
authors.lastname: Dufouil
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001284:Atrophy / Q000473:pathology; D004522:Educational Status; D005260:Female; D005500:Follow-Up Studies; D006624:Hippocampus / Q000000981:diagnostic imaging*; D006803:Human Development; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012923:Social Class; D012937:Social Mobility