title: Is JAK2V617F Mutation the Only Factor for Thrombosis in Philadelphia-Negative Chronic Myeloproliferative Neoplasms?
abstract: The most common genetic disorder in Philadelphia negative chronic myeloproliferative neoplasms is the JAK2-V617F mutation. In the present study, we aimed to determine risk factors for thrombosis in patients with essential thrombocytosis and polycythemia vera. We screened the medical records of 101 patients. Risk factors which may predict thrombosis were recorded. Venous thrombosis (VT) before diagnosis was significantly higher in JAK2 positive patients. VT after diagnosis was similar in JAK2 positive and negative groups, and was significantly higher in elderly patients. Treatment places importance on the JAK2 mutation under unmodifiable cardiovascular risk factors such as advanced age after diagnosis.
authors.affiliation: Department of Hematology, Trakya University Medical Faculty, Edirne, Turkey.
authors.forename: Mehmet Sevki
authors.initials: MS
authors.lastname: Uyanik
authors.affiliation: Department of Internal Medicine, Trakya University Medical Faculty, Edirne, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Baysal
authors.affiliation: Department of Hematology, Trakya University Medical Faculty, Edirne, Turkey ; Eski Yildiz Cad. Park Apt. No:22, Daire:18, 34349 Besiktas-Istanbul, Turkey.
authors.forename: Gulsum Emel
authors.initials: GE
authors.lastname: Pamuk
authors.affiliation: Department of Hematology, Trakya University Medical Faculty, Edirne, Turkey.
authors.forename: Muhammet
authors.initials: M
authors.lastname: Maden
authors.affiliation: Department of Internal Medicine, Trakya University Medical Faculty, Edirne, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Akker
authors.affiliation: Department of Hematology, Trakya University Medical Faculty, Edirne, Turkey.
authors.forename: Elif Gulsum
authors.initials: EG
authors.lastname: Umit
authors.affiliation: Department of Hematology, Trakya University Medical Faculty, Edirne, Turkey.
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Demir
authors.affiliation: Department of Internal Medicine, Trakya University Medical Faculty, Edirne, Turkey.
authors.forename: Erkan
authors.initials: E
authors.lastname: Aydogdu
keywords: Allele burden; Chronic myeloproliferative neoplasms; JAK2 mutation; Thrombosis