title: Prognostic Impact of Epidermal Growth Factor Receptor Overexpression in Patients with Cervical Cancer: A Meta-Analysis.
abstract: Clinical trials have provided conflicting results regarding whether epidermal growth factor receptor (EGFR) overexpression predicts poor survival in cervical cancer patients. In this study, we perform a meta-analysis of the association between EGFR expression and survival in cervical cancer patients. We searched clinical studies in the Medline, PubMed, Embase, and Web of Science databases. A total of 22 studies with 2,505 patients were included, and pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated for each study. Heterogeneity was assessed using Higgins I2 to select a Mantel-Haenszel fixed effects model (I2 ≤50%) or a DerSimonian-Laird random effects model (I2 ≥50%). High EGFR levels predicted poor overall survival (OS) (HR: 1.40, 95% CI: 1.10-1.78) and disease-free survival (DFS) (HR: 1.84, 95% CI: 1.51-2.24). Stratified analyses showed that EGFR overexpression was significantly related to poor DFS in patients treated with chemoradiation or surgery. Moreover, the pooled odds ratios (ORs) revealed associations between EGFR expression and clinicopathological features, such as lymph node metastasis (OR: 1.72, 95% CI: 1.23-2.40) and tumor size ≥4 cm (OR: 1.64, 95% CI: 1.20-2.23). This meta-analysis demonstrates that EGFR overexpression is closely associated with reduced survival in patients with cervical cancer. These results may facilitate the individualized management of clinical decisions for anti-EGFR therapies in cervical cancer patients.
authors.affiliation: Department of Obstetrics and Gynecology, Guizhou Provincial People's Hospital, Guiyang, Guizhou, P. R. China.
authors.forename: Wei-Jie
authors.identifier: http://orcid.org/0000-0001-7235-4164
authors.initials: WJ
authors.lastname: Tian
authors.affiliation: Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, P. R. China.
authors.forename: Miao-Ling
authors.initials: ML
authors.lastname: Huang
authors.affiliation: Department of Obstetrics and Gynecology, Guizhou Provincial People's Hospital, Guiyang, Guizhou, P. R. China.
authors.forename: Qing-Feng
authors.initials: QF
authors.lastname: Qin
authors.affiliation: Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, P. R. China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Department of Obstetrics and Gynecology, Guizhou Provincial People's Hospital, Guiyang, Guizhou, P. R. China.
authors.forename: Kun
authors.initials: K
authors.lastname: Fang
authors.affiliation: Department of Obstetrics and Gynecology, Guizhou Provincial People's Hospital, Guiyang, Guizhou, P. R. China.
authors.forename: Ping-Ling
authors.initials: PL
authors.lastname: Wang
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000235:genetics* / Q000401:mortality / Q000601:surgery; D018572:Disease-Free Survival; D066246:ErbB Receptors / Q000235:genetics* / Q000627:therapeutic use; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008207:Lymphatic Metastasis; D011379:Prognosis; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000401:mortality / Q000601:surgery
chemical_list: D000911:Antibodies, Monoclonal; C512478:EGFR protein, human; D066246:ErbB Receptors