title: [Effects of diets with different n-6/n-3 fatty acids on cardiovascular risk factors in mice fed high-fat diets].
abstract: To investigate effects of diets with different fatty acid composition on serum lipid profiles, inflammation, oxidative stress and endothelial function in mice fed high-fat diets.
  
  
  METHODS
  Male KM mice were randomly divided into five groups and were fed normal control diet, high-fat lard diet, high-fat diets with n-6/n-3 polyunsaturated fatty acid (PUFA) ratios of 1:1, 5:1 nd 2:1 for fiv weeks, respectively. The levels of serum triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C ) iterlekin-6 (IL-6), alonildehyde (MDA), hypersensitive C-reactive protein (hs-CRP), tumor ncrosis factor alpha (TNF-alpha), lipid lphaproxide (LPO), 8-iso postaglandin F2aalpha (8-iso-PGlphaF2u), oxidialphaed low-density lipoprotein (ox-LDL), free faty acid (FFA), E-selectin (ES) and von Willebrand factor (vWF) were measured.
  
  
  RESULTS
  The levels of serum LDL-C and non-HDL-C in the lard group were significantly higher than those in the other groups (P < 0.05). Th e ard group had. significntly higher serum TG and TC concentrations compared to 1:1 and 5: groups P <0. 05). The evels of serum FFA in 20:1 group wre significantly higher than those in 1:1 and 5:1 groups P < 0.05). Co mpred with the lard and 20:1 groups,the 1:1 and 5:1 groups displayed lower levels of inflammatory cytokines, oxidative stress and ES. The 5:1 group sgnificantly decreased the level of serum vWF compared to lard and 20:1 groups P < 0.05).
  
  
  CONCLUSIONS
  diet with low n-6/n-3 PUFA ratio could improve lipid metabolism, inflammation, oxidative stress and endothelial function compared to high-fat diets with lard and higher n-6/n-3 PUFA ratio. The diet with low n-6/n-3 PUFA ratio can improve cardiovascular disease risk factors to prevent cardiovascular disease.
authors.forename: Ligang
authors.initials: L
authors.lastname: Yang
authors.forename: Zhixiu
authors.initials: Z
authors.lastname: Song
authors.forename: Weixin
authors.initials: W
authors.lastname: Cao
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Wang
authors.forename: Huixia
authors.initials: H
authors.lastname: Lu
authors.forename: Fei
authors.initials: F
authors.lastname: Guo
authors.forename: Huijun
authors.initials: H
authors.lastname: Yang
authors.forename: Jianshuang
authors.initials: J
authors.lastname: Chen
authors.forename: Shaokang
authors.initials: S
authors.lastname: Wang
authors.forename: Guiju
authors.initials: G
authors.lastname: Sun
mesh_terms: D000818:Animals; D002097:C-Reactive Protein / Q000032:analysis; D002318:Cardiovascular Diseases / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D059305:Diet, High-Fat / Q000009:adverse effects*; D004041:Dietary Fats; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D043371:Fatty Acids, Omega-6 / Q000008:administration & dosage*; D007249:Inflammation; D050356:Lipid Metabolism; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D051379:Mice; D011897:Random Allocation; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D008078:Cholesterol, LDL; D004041:Dietary Fats; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D008075:Lipoproteins, HDL; D014280:Triglycerides; D002097:C-Reactive Protein; D002784:Cholesterol; C029310:lard