title: Magnetic resonance imaging in pediatric sickle cell anemia.
abstract: Sickle cell disease is the result of altered genetic make up due to hereditary encounter and its form as homozygous sickle cell anemia is the most common and severe. The disease is characterized by chronic anemia, recurrent pain crises and vascular occlusion. Neurologically, there is a high incidence of stroke in childhood, as well as cognitive dysfunction. Newborn screening programmes and preventative treatments have allowed a much longer lifespan. However, recently, neurological research has shifted to characterizing more subtle aspects of brain development and functioning that may be critically important to the individual's quality of life. The present review article examines the neurological and neurocognitive complications of sickle cell disease, and discusses the importance of magnetic resonance imaging scans in the management of the disease.
authors.affiliation: Department of Radiology, Xuzhou Children's Hospital, Xuzhou, Jiangsu 221002, P.R. China.
authors.forename: Xinxian
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Radiology, Xuzhou Children's Hospital, Xuzhou, Jiangsu 221002, P.R. China.
authors.forename: Chenglong
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Radiology, Xuzhou Children's Hospital, Xuzhou, Jiangsu 221002, P.R. China.
authors.forename: Qiancheng
authors.initials: Q
authors.lastname: Li
keywords: magnetic resonance imaging; sickle cell disease; stroke