title: Clinicopathologic features of gastric carcinoma with lymphoid stroma in early gastric cancer.
abstract: OBJECTIVE
  Gastric carcinoma with lymphoid stroma (GCLS) is a rare variant of gastric cancer. The aims of this study were to investigate the clinicopathologic features of GCLS in early gastric cancer (EGC).
  
  
  METHODS
  Analysis included 3,385 patients who were diagnosed with EGC after surgery between 2005 and 2012. This study compared GCLS with non-GCLS patients in terms of clinicopathological features including lymph node metastasis (LNM).
  
  
  RESULTS
  Forty-one (1.2%) patients were diagnosed as GCLS among those with EGC. When GCLS and non-GCLS patients were compared, the GCLS group showed a greater predominance among males, greater tendency towards proximal location, a more elevated gross appearance, and deeper submucosal invasion. In particular, more than 90% of GCLS cases showed deep submucosal invasion. The LNM rate was significantly lower in GCLS than non-GCLS cases after adjustment for depth of invasion. Among the GCLS group, there was no LNM in the cases with lesions confined to the mucosa or submucosal invasive lesions with tumor size ≤10 mm.
  
  
  CONCLUSIONS
  In EGC, GCLS showed deeper submucosal invasion and a lower LNM rate compared with non-GCLS. Thus, clinical considerations of GCLS may be helpful to decide on a specific cancer treatment. J. Surg. Oncol. 2016;114:769-772. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Cheal Wung
authors.initials: CW
authors.lastname: Huh
authors.affiliation: Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Da Hyun
authors.initials: DH
authors.lastname: Jung
authors.affiliation: Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Hyunki
authors.initials: H
authors.lastname: Kim
authors.affiliation: Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Hoguen
authors.initials: H
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Young Hoon
authors.initials: YH
authors.lastname: Youn
authors.affiliation: Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Hyojin
authors.initials: H
authors.lastname: Park
authors.affiliation: Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Jong Won
authors.initials: JW
authors.lastname: Kim
authors.affiliation: Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Seung Ho
authors.initials: SH
authors.lastname: Choi
authors.affiliation: Department of Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Sung Hoon
authors.initials: SH
authors.lastname: Noh
authors.affiliation: Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. otilia94@yuhs.ac.
authors.forename: Jie-Hyun
authors.initials: JH
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D055088:Early Detection of Cancer; D005260:Female; D005743:Gastrectomy; D005753:Gastric Mucosa / Q000473:pathology*; D006801:Humans; D008207:Lymphatic Metastasis; D008221:Lymphoid Tissue / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D016019:Survival Analysis
keywords: early gastric cancer; gastric carcinoma with lymphoid stroma; lymph node metastasis