title: The effect of trapidil on the reactive astrocytic proliferation following spinal cord trauma in rats: Light and electron microscopic findings.
abstract: Platelet-derived growth factor (POCF) released from platelets is one ofthe mitogens in serum, which plays a major role upon the cell biology, namely enhancing cell division and controlling of the maturation, especially upon the glial cell growth and its differentiation. Trapidil, which is an anti-POCF agent, inhibits the effect of POCF, especially the proliferative effects on the glial and tumoral cells in vitro. Previous studies suggested that the astrocytic proliferation stimulated by POCF was inhibited by trapidil via the selective antagonism. Trapidil was not found to have a considerable effect on the prevention of nonpermissive astrocytes in this study. It should be theorised that trapidil, administered immediately even after the trauma, could not reach the injury site in effective measure because of secondary events such as edema and impairment of blood circulation. This suggestion should be another subject for studies concerning trapidil which is administered prior to the trauma. [Neural Res 1998; 20: 365-373].
authors.affiliation: a Department of Neurosurgery , Çukurova University, School of Medicine , Salcali , Adana , Turkey.
authors.forename: A I
authors.initials: AI
authors.lastname: Göçer
authors.affiliation: b Department of Histology , Çukurova University, School of Medicine , Salcali , Adana , Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Polat
authors.affiliation: a Department of Neurosurgery , Çukurova University, School of Medicine , Salcali , Adana , Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Özel
authors.affiliation: a Department of Neurosurgery , Çukurova University, School of Medicine , Salcali , Adana , Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Tuna
authors.affiliation: b Department of Histology , Çukurova University, School of Medicine , Salcali , Adana , Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Kaya
authors.affiliation: a Department of Neurosurgery , Çukurova University, School of Medicine , Salcali , Adana , Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Çetinalp
authors.affiliation: a Department of Neurosurgery , Çukurova University, School of Medicine , Salcali , Adana , Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Haciyakupoglu
keywords: Astrocyte proliferation; Platelet-derived growth factor; Spinal cord injury; Trapidil