title: Bio-orthogonally Deciphered Binary Nanoemitters for Tumor Diagnostics.
abstract: Bioinspired design concept has been recognized as one of the most promising strategies for discovering new biomaterials. However, smart biomaterials that are of growing interests in biomedical field need biological processability to meet their emergent applications in vivo. Herein, a new bio-orthogonally deciphered approach has been demonstrated for modulating optical properties of nanomaterials in living systems. The self-assembled nanoemitters based on cyanine-pyrene molecule 1 with inert optical property are designed and prepared. The structure and optical feature of the nanoemitters 1 can be efficiently and reliably modulated by a unique bio-orthogonal mechanism with abundant glutathione (GSH) as an activator. As a result, the self-assembled nanoemitters 1 spontaneously exhibits binary emissions for high-performance tumor imaging in vivo. We believe that this bio-orthogonally deciphered strategy opens a new avenue for designing variable smart biomaterials or devices in biomedical applications.
authors.affiliation: CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST) , No. 11 Beiyitiao, Zhongguancun, Beijing, China.|University of Chinese Academy of Science (UCAS) , No. 19A Yuquan Road, Beijing, China.
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: An
authors.affiliation: CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST) , No. 11 Beiyitiao, Zhongguancun, Beijing, China.|University of Chinese Academy of Science (UCAS) , No. 19A Yuquan Road, Beijing, China.
authors.forename: Sheng-Lin
authors.initials: SL
authors.lastname: Qiao
authors.affiliation: CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST) , No. 11 Beiyitiao, Zhongguancun, Beijing, China.
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Li
authors.affiliation: CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST) , No. 11 Beiyitiao, Zhongguancun, Beijing, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Yang
authors.affiliation: CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST) , No. 11 Beiyitiao, Zhongguancun, Beijing, China.|University of Chinese Academy of Science (UCAS) , No. 19A Yuquan Road, Beijing, China.
authors.forename: Yao-Xin
authors.initials: YX
authors.lastname: Lin
authors.affiliation: CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST) , No. 11 Beiyitiao, Zhongguancun, Beijing, China.|University of Chinese Academy of Science (UCAS) , No. 19A Yuquan Road, Beijing, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.affiliation: CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST) , No. 11 Beiyitiao, Zhongguancun, Beijing, China.
authors.forename: Zeng-Ying
authors.initials: ZY
authors.lastname: Qiao
authors.affiliation: CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST) , No. 11 Beiyitiao, Zhongguancun, Beijing, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST) , No. 11 Beiyitiao, Zhongguancun, Beijing, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
mesh_terms: D001672:Biocompatible Materials; D003952:Diagnostic Imaging / Q000295:instrumentation / Q000379:methods*; D049329:Nanostructures; D009369:Neoplasms / Q000000981:diagnostic imaging*
chemical_list: D001672:Biocompatible Materials
keywords: bio-orthogonal; nanoparticles; self-assembly; supramolecular; tumor