title: Cardiovascular risk of BRCA1/2 mutation carriers: A review.
abstract: BRCA1/2 mutation carriers are at high risk of breast and ovarian cancer. The number of studies on non-cancer endpoints in BRCA1/2 mutation carriers is still limited. BRCA1/2 mutation carriers may be at higher cardiovascular risk due to early menopause after risk-reducing salpingo-oophorectomy and/or due to the potential cardiotoxic effects of breast cancer treatment (radiotherapy and chemotherapy). Moreover, BRCA genes have a role as a gatekeeper in cardiac function and structure, which may affect susceptibility to cardiac damage. Our goal is to review current knowledge of cardiovascular risk among BRCA1/2 mutation carriers.
authors.affiliation: Department of Obstetrics and Gynaecology, Radboud University Medical Center, Nijmegen, The Netherlands, The Netherlands.
authors.forename: L L M
authors.initials: LL
authors.lastname: van Westerop
authors.affiliation: Department of Obstetrics and Gynaecology, Radboud University Medical Center, Nijmegen, The Netherlands, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Arts-de Jong
authors.affiliation: Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands, The Netherlands.
authors.forename: N
authors.initials: N
authors.lastname: Hoogerbrugge
authors.affiliation: Department of Obstetrics and Gynaecology, Radboud University Medical Center, Nijmegen, The Netherlands, The Netherlands.
authors.forename: J A
authors.initials: JA
authors.lastname: de Hullu
authors.affiliation: Department of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands, The Netherlands. Electronic address: angela.maas@radboudumc.nl.
authors.forename: A H E M
authors.initials: AH
authors.lastname: Maas
mesh_terms: D019313:BRCA1 Protein / Q000235:genetics*; D024682:BRCA2 Protein / Q000235:genetics*; D001943:Breast Neoplasms / Q000150:complications / Q000235:genetics*; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D009154:Mutation; D012307:Risk Factors; D040242:Risk Reduction Behavior; D016387:Women's Health
chemical_list: D019313:BRCA1 Protein; D024682:BRCA2 Protein
keywords: BRCA; Cardio-oncology; Cardiotoxicity; Cardiovascular disease; Salpingo-oophorectomy