title: [Association of PLEKHA7, COL11A1 and PCMTD1-ST18 gene polymorphisms with primary angle closure glaucoma in ethnic Han Chinese from Sichuan].
abstract: OBJECTIVE
  To assess the association of single nucleotide polymorphisms (SNPs) of PLEKHA7, COL11A1 and PCMTD1-ST18 genes and primary angle closure glaucoma (PACG) among ethnic Han Chinese from Sichuan Province.
  
  
  METHODS
  In this study, 362 subjects with PACG and 1056 age- and sex-matched healthy controls were recruited. Genotypes of 3 reported SNPs, including PLEKHA7 rs11024102, COL11A1 rs3753841 and PCMTD1-ST18 rs1015213 were determined with a SNaPshot method.
  
  
  RESULTS
  The P values for the genotype frequencies of rs11024102, rs3753841 and rs1015213 between the patient and control groups were 0.62 (OR=1.09, 95%CI: 0.91-1.30), 0.42 (OR=1.04, 95%CI: 0.87-1.41) and 0.34 (OR=1.35, 95%CI: 0.73-2.49), respectively. And the P values for the allele frequency distributions of PLEKHA7 rs11024102, COL11A1 rs3753841 and PCMTD1-ST18 rs1015213 between the two groups were 0.347, 0.698 and 0.344, respectively.
  
  
  CONCLUSIONS
  No significant association of PLEKHA7 rs11024102, COL11A1 rs3753841 and PCMTD1-ST18 rs1015213 with PACG was found among ethnic Han Chinese from Sichuan.
authors.affiliation: Southwestern Medical University, Luzhou, Sichuan 646000, China; Sichuan Key Laboratory for Disease Gene Study, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610000, China. Email: zliny@yahoo.com.
authors.forename: Chang
authors.initials: C
authors.lastname: Tan
authors.forename: Lulin
authors.initials: L
authors.lastname: Huang
authors.forename: Zhenglin
authors.initials: Z
authors.lastname: Yang
mesh_terms: D002352:Carrier Proteins / Q000235:genetics*; D002681:China / Q000208:ethnology; D024161:Collagen Type XI / Q000235:genetics*; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000235:genetics*; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D026601:Protein D-Aspartate-L-Isoaspartate Methyltransferase / Q000235:genetics*
chemical_list: C574182:COL11A1 protein, human; D002352:Carrier Proteins; D024161:Collagen Type XI; C533786:PLEKHA7 protein, human; C584062:PCMTD1 protein, human; D026601:Protein D-Aspartate-L-Isoaspartate Methyltransferase