title: [Biological role of heterogeneous glycoprotein structures].
abstract: Carbohydrate molecules connected mostly with covalent junctions to protein chains are called glycoproteins. These carbohydrate molecules are attached to the protein core in different qualities and order. When the protein core is connected with acidic components such as uronic acid or SO4 radicals, they are called proteoglycans. The currently used name "glycosaminoglycan" in this case is not entirely correct. In the living world polymannane structures occur, too. Glycoproteins do not only exceptionally hold acidic groups but they have neuraminic acid derivatives. Tissue, cellular and matrix structures, and mostly all serum "proteins" are mainly glycoproteins. In the everyday clinical practice glycoproteins are mentioned as proteins. Nevertheless, the inadequate use of the concept may cause errors in the attitudes, too. This paper aims to correct this notion, because the term of "glycobiology" has already been expanded to be an independent scientific field. The practical clinical consequences of recent knowledge in this field are also summarized including novel findings on glycoprotein structures and functions. The importance of the quantity of carbohydrates, and their structural arrangements are also presented. In short, significance of glycoprotein-carbohydrate structures, as well as their physiological and pathological roles are reviewed in order to introduce the field of "glycobiology". Orosomucoid and immunoglobulins are discussed separately. Orv. Hetil., 2016, 157(30), 1185-1192.
authors.affiliation: III. Belgyógyászati Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Kútvölgyi út 4., 1125.
authors.forename: Lajos
authors.initials: L
authors.lastname: Jakab
mesh_terms: D006023:Glycoproteins / Q000737:chemistry* / Q000378:metabolism*; D006025:Glycosaminoglycans / Q000737:chemistry / Q000378:metabolism; D006031:Glycosylation; D006801:Humans; D007136:Immunoglobulins / Q000737:chemistry / Q000378:metabolism*; D009961:Orosomucoid / Q000737:chemistry / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D006023:Glycoproteins; D006025:Glycosaminoglycans; D007136:Immunoglobulins; D009961:Orosomucoid
keywords: biological roles; clinical significance; funkció; glikoprotein; glycoproteins; klinikai jelentőség; protein; structures; szerkezet