title: Metabolomic analysis of percutaneous fine-needle aspiration specimens of thyroid nodules: Potential application for the preoperative diagnosis of thyroid cancer.
abstract: Thyroid nodules are a very common problem. Since malignant thyroid nodules should be treated surgically, preoperative diagnosis of thyroid cancer is very crucial. Cytopathologic analysis of percutaneous fine-needle aspiration (FNA) specimens is the current gold standard for diagnosing thyroid nodules. However, this method has led to high rates of inconclusive results. Metabolomics has emerged as a useful tool in medical fields and shown great potential in diagnosing various cancers. Here, we evaluated the potential of nuclear magnetic resonance (NMR) analysis of percutaneous FNA specimens for preoperative diagnosis of thyroid cancer. We analyzed metabolome of FNA samples of papillary thyroid carcinoma (n = 35) and benign follicular nodule (n = 69) using a proton NMR spectrometer. The metabolomic profiles showed a considerable discrimination between benign and malignant nodules. Receiver operating characteristic (ROC) curve analysis indicated that seven metabolites could serve as discriminators (area under ROC curve value, 0.64-0.85). These findings demonstrated that NMR analysis of percutaneous FNA specimens of thyroid nodules can be potentially useful in the accurate and rapid preoperative diagnosis of thyroid cancer.
authors.affiliation: Department of Radiology, Korea University Guro Hospital, Seoul, Korea.
authors.forename: Inseon
authors.initials: I
authors.lastname: Ryoo
authors.affiliation: College of Pharmacy, Natural Product Research Institute, Seoul National University, Seoul, Korea.
authors.forename: Hyuknam
authors.initials: H
authors.lastname: Kwon
authors.affiliation: Department of Radiology, Seoul National University Healthcare system Gangnam center, Seoul, Korea.
authors.forename: Soo Chin
authors.initials: SC
authors.lastname: Kim
authors.affiliation: Department of Radiology and Research Institute of Radiology, University of Ulsan college of Medicine, Asan Medical Center, Seoul, Korea.
authors.forename: Seung Chai
authors.initials: SC
authors.lastname: Jung
authors.affiliation: Department of Radiology, Pusan National University Yangsan Hospital, Yangsan, Korea.
authors.forename: Jeong A
authors.initials: JA
authors.lastname: Yeom
authors.affiliation: Departement of Radiology, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Korea.
authors.forename: Hwa Seon
authors.initials: HS
authors.lastname: Shin
authors.affiliation: Department of Radiology, Seoul National University Hospital, College of Medicine, Seoul, Korea.|Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, Korea.
authors.forename: Hye Rim
authors.initials: HR
authors.lastname: Cho
authors.affiliation: Department of Radiology, Seoul National University Hospital, College of Medicine, Seoul, Korea.
authors.forename: Tae Jin
authors.initials: TJ
authors.lastname: Yun
authors.affiliation: Department of Radiology, Seoul National University Hospital, College of Medicine, Seoul, Korea.
authors.forename: Seung Hong
authors.initials: SH
authors.lastname: Choi
authors.affiliation: Department of Radiology, Seoul National University Hospital, College of Medicine, Seoul, Korea.
authors.forename: Chul-Ho
authors.initials: CH
authors.lastname: Sohn
authors.affiliation: College of Pharmacy, Natural Product Research Institute, Seoul National University, Seoul, Korea.
authors.forename: Sunghyouk
authors.initials: S
authors.lastname: Park
authors.affiliation: Department of Radiology, Seoul National University Hospital, College of Medicine, Seoul, Korea.
authors.forename: Ji-Hoon
authors.initials: JH
authors.lastname: Kim
mesh_terms: D000328:Adult; D001685:Biological Factors / Q000032:analysis*; D044963:Biopsy, Fine-Needle; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D055432:Metabolomics; D008875:Middle Aged; D012372:ROC Curve; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D016606:Thyroid Nodule / Q000175:diagnosis* / Q000473:pathology*
chemical_list: D001685:Biological Factors