title: Adding Water to the Mill: Olmesartan-Induced Collagenous Sprue-A Case Report and Brief Literature Review.
abstract: Collagenous sprue (CS) is a distinct clinicopathological disorder histologically defined by a thickened subepithelial band (Freeman, 2011). It is a rare condition which has been recently observed in a significant proportion of sprue-like enteropathy associated with olmesartan, a novel entity described by Rubio-Tapia et al. in 2012. CS is historically associated with a poor prognosis (Marthey et al., 2014). However, histological and clinical improvements have been described in most studies with concomitant usage of corticosteroids and/or gluten-free diet (Marthey et al., 2014). We report a unique case of olmesartan-induced collagenous sprue in a 79-year-old man that showed complete histological and clinical remission with the sole withdrawal of the incriminating drug. The literature on this topic is briefly reviewed.
authors.affiliation: Gastroenterology Service, Charles-LeMoyne Hospital, Sherbrooke University, Greenfield Park, QC, Canada J4V 2H1.
authors.forename: Claudine
authors.initials: C
authors.lastname: Desruisseaux
authors.affiliation: Gastroenterology Service, Charles-LeMoyne Hospital, Sherbrooke University, Greenfield Park, QC, Canada J4V 2H1.
authors.forename: Michaël
authors.initials: M
authors.lastname: Bensoussan
authors.affiliation: Gastroenterology Service, Charles-LeMoyne Hospital, Sherbrooke University, Greenfield Park, QC, Canada J4V 2H1.
authors.forename: Etienne
authors.initials: E
authors.lastname: Désilets
authors.affiliation: Gastroenterology Service, Charles-LeMoyne Hospital, Sherbrooke University, Greenfield Park, QC, Canada J4V 2H1.
authors.forename: Hanh-Khiem
authors.initials: HK
authors.lastname: Tran
authors.affiliation: Pathology Department, Charles-LeMoyne Hospital, Sherbrooke University, Greenfield Park, QC, Canada J4V 2H1.
authors.forename: Robert
authors.initials: R
authors.lastname: Arcand
authors.affiliation: Intensive Care Unit, Charles-LeMoyne Hospital, Sherbrooke University, Greenfield Park, QC, Canada J4V 2H1.
authors.forename: Germain
authors.initials: G
authors.lastname: Poirier
authors.affiliation: Gastroenterology Service, Charles-LeMoyne Hospital, Sherbrooke University, Greenfield Park, QC, Canada J4V 2H1.
authors.forename: Andrew
authors.initials: A
authors.lastname: Wisniewski
authors.affiliation: Gastroenterology Service, Charles-LeMoyne Hospital, Sherbrooke University, Greenfield Park, QC, Canada J4V 2H1.
authors.forename: Thibaut
authors.initials: T
authors.lastname: Manière
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000009:adverse effects*; D064068:Collagenous Sprue / Q000139:chemically induced*; D003967:Diarrhea / Q000139:chemically induced; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007093:Imidazoles / Q000009:adverse effects*; D008297:Male; D013777:Tetrazoles / Q000009:adverse effects*; D028761:Withholding Treatment
chemical_list: D000959:Antihypertensive Agents; D007093:Imidazoles; D013777:Tetrazoles; C437965:olmesartan