title: Potential for tyndalizedLactobacillus acidophilusas an effective component in moisturizing skin and anti-wrinkle products.
abstract: It is widely accepted that ultraviolet (UV) irradiation induces skin damage. In the present study, a UVB-induced hairless mouse model of skin photoaging was developed to determine whether tyndalizedLactobacillus acidophiluswas able to significantly enhance the repair of photodamaged skin. To evaluate the effects of tyndalizedL. acidophiluson UVB-induced skin-wrinkle formationin vivo, HR-1 hairless male mice were exposed to UVB radiation and orally administered tyndalizedL. acidophilus. Compared with the control group, the UVB irradiation mice displayed a significant increase in transepidermal water loss and a reduction in skin hydration. In mice with UVB-induced photodamage, the effacement of the fine wrinkles by tyndalizedL. acidophiluswas correlated with dermal collagen synthesis, accompanied by histological changes. Furthermore, western blotting was performed to investigate the protein expression levels of matrix metalloproteinases (MMPs) and mitogen-activated protein kinase. Notably, orally administered tyndalizedL. acidophilusreduced the expression levels of MMP-1 and MMP-9. Based upon the aforementioned results, it was determined that tyndalizedL. acidophiluseffectively inhibited the wrinkle formation induced by UVB irradiation, and that this may be attributed to the downregulation of MMPs. Therefore, tyndalizedL. acidophilusmay be considered a potential agent for preventing skin photoaging and wrinkle formation.
authors.affiliation: KM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea.
authors.forename: A-Rang
authors.initials: AR
authors.lastname: Im
authors.affiliation: Division of AIDS, Center for Immunology and Pathology, Korea National Institute of Health, Cheongju, Chungbuk 363-951, Republic of Korea.
authors.forename: Hui Seong
authors.initials: HS
authors.lastname: Kim
authors.affiliation: School of Medicine and Institute for Nuclear Science and Technology, Jeju National University, Jeju-si, Jeju-do 690-756, Republic of Korea.
authors.forename: Jin Won
authors.initials: JW
authors.lastname: Hyun
authors.affiliation: KM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea.
authors.forename: Sungwook
authors.initials: S
authors.lastname: Chae
keywords: anti-wrinkle; matrix metalloproteinases; mitogen-activated protein kinase; transepidermal water loss; tyndalized Lactobacillus acidophilus