title: Free/Total Serum Prostate-Specific Antigen Ratio in Women with Colorectal Cancer Has Prognostic Significance.
abstract: OBJECTIVE
  The presence of prostate-specific antigen (PSA) in colon cancer tissues has been shown, but its clinical significance has not been known yet in colorectal cancer patients. We investigated the prognostic significance of percent free PSA value (free PSA/total PSA × 100) in female patients with colorectal cancer.
  
  
  METHODS
  The serum concentrations of total and free PSA were measured by solid-phase two-site immunoradiometric assay in 184 patients.
  
  
  RESULTS
  The cancer-specific survival (CSS) of patients with percent free PSA value ≥35 was significantly better compared to that of patients with percent free PSA value <35 (CSS rate was 82.9 and 55.5 %, respectively; log-rank x2= 8135, p = 0.004). In multivariate Cox analysis, this percent free PSA threshold value had independent prognostic significance (relative risk 0.27, 95 % confidence interval 0.11-0.64, p = 0.003).
  
  
  CONCLUSIONS
  Percent free PSA value, calculated by serum total and free PSA levels, has prognostic significance in women with colorectal cancer. The studies with larger patient series, utilizing ultrasensitive PSA assays whose lowest detection limit is lower, are required for a clearer understanding of this issue.
authors.affiliation: Department of Surgery, SB Okmeydanı Training and Research Hospital, İstanbul, Turkey. nuvitduraker@gmail.com.
authors.forename: Nüvit
authors.initials: N
authors.lastname: Duraker
authors.affiliation: Department of Surgery, Bayındır Levent Hospital, İstanbul, Turkey.
authors.forename: Zeynep Civelek
authors.initials: ZC
authors.lastname: Çaynak
authors.affiliation: Department of Surgery, SB İstanbul Training and Research Hospital, İstanbul, Turkey.
authors.forename: Didem Can
authors.initials: DC
authors.lastname: Trabulus
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000097:blood*; D005260:Female; D006801:Humans; D007610:Kallikreins / Q000097:blood*; D008875:Middle Aged; D011379:Prognosis; D017430:Prostate-Specific Antigen / Q000097:blood*; D016019:Survival Analysis; D015996:Survival Rate; D055815:Young Adult
chemical_list: C549870:KLK3 protein, human; D007610:Kallikreins; D017430:Prostate-Specific Antigen
keywords: Colorectal carcinoma; Female patient; PSA; Percentage of free PSA; Survival