title: CdSe/ZnS Core/Shell Quantum Dots in Cooperation with Other Materials for Direct and Indirect Production of Reactive Oxygen Species.
abstract: In this present work, CdSe/ZnS core/shell quantum dots (QDs) were exploited in the oxidation reactions of 5-aminolevulinic acid (ALA) and glutamate (GLU) for the production of reactive oxygen species (ROS). Fast and highly efficient oxidation reactions of ALA to produce the hydroxyl radicals (HO*) and of GLU to produce the superoxide anion (O2*-) were observed in the cooperation of mercaptopropionic acid (MPA) capped-CdSe/ZnS QDs (MPA-QDs) under LED irradiation. Whereas, binding between MPA-QDs and coumarin-derived dendrimer (CdD)-captured silica particles (SiCdDs) through sol-gel GA enhanced singlet oxygen production under LED irradiation by about 80% as compared to that achieved using QDs only. Confocal fluorescent microscopic images of the size and morphology of HeLa cells confirmed the ROS production from ALA, GLU in cooperation with CdSe/ZnS QDs or QDs-coated SiCdDs under LED irradiation.
authors.forename: Hong Dinh
authors.initials: HD
authors.lastname: Duong
authors.forename: Hyun
authors.initials: H
authors.lastname: Park
authors.forename: Jong Il
authors.initials: JI
authors.lastname: Rhee
mesh_terms: D019187:Cadmium Compounds / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D018613:Microscopy, Confocal; D045663:Quantum Dots; D017382:Reactive Oxygen Species / Q000378:metabolism*; D018036:Selenium Compounds / Q000737:chemistry*; D017967:Zinc Compounds / Q000737:chemistry*
chemical_list: D019187:Cadmium Compounds; D017382:Reactive Oxygen Species; D018036:Selenium Compounds; D017967:Zinc Compounds; C058667:cadmium selenide; C044696:zinc selenide