title: Drug fever induced by piperacillin/tazobactam in an elderly patient with underlying human immunodeficiency virus (HIV) infection.
abstract: Our search of the literature revealed no detailed case reports about drug fever induced by piperacillin/tazobactam in a patient with HIV infection although there were a few case reports about drug fever due to piperacillin/tazobactam with other comorbidities. A 63-year-old male patient with HIV positive was admitted for acute cholecystitis. He was started on piperacillin/tazobactam. For the next 8 days, he had intermittent fever up to 103°F (39.4°C) with relative bradycardia although he showed clinical improvement. There was no laboratory or imaging findings suggestive of another infectious source and drug fever was suspected. The antibiotics were stopped and after 48 hours no fever was observed until the day of discharge. Piperacillin/tazobactam can induce fever in patients with cystic fibrosis and in patients with other conditions. Drug fever may be more prevalent in patients with HIV infection. It has no characteristic pattern and may not be associated with eosinophilia.
authors.affiliation: Department of Internal Medicine, Interfaith Medical Center, Brooklyn, New York, USA.
authors.forename: Thein
authors.initials: T
authors.lastname: Swe
authors.affiliation: Department of Internal Medicine, Interfaith Medical Center, Brooklyn, New York, USA.
authors.forename: Mir
authors.initials: M
authors.lastname: Ali
authors.affiliation: Department of Internal Medicine, Interfaith Medical Center, Brooklyn, New York, USA.
authors.forename: Akari Thein
authors.initials: AT
authors.lastname: Naing
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D041881:Cholecystitis, Acute / Q000150:complications* / Q000188:drug therapy*; D005334:Fever / Q000139:chemically induced*; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010397:Penicillanic Acid / Q000009:adverse effects / Q000031:analogs & derivatives*; D010878:Piperacillin / Q000009:adverse effects; D000077725:Piperacillin, Tazobactam Drug Combination
chemical_list: D000900:Anti-Bacterial Agents; D000077725:Piperacillin, Tazobactam Drug Combination; D010397:Penicillanic Acid; D010878:Piperacillin