title: Two for the Price of One: A Neuroprotective Chaperone Kit within NAD Synthase Protein NMNAT2.
abstract: One of the most fascinating properties of the brain is the ability to function smoothly across decades of a lifespan. Neurons are nondividing mature cells specialized in fast electrical and chemical communication at synapses. Often, neurons and synapses operate at high levels of activity through sophisticated arborizations of long axons and dendrites that nevertheless stay healthy throughout years. On the other hand, aging and activity-dependent stress strike onto the protein machineries turning proteins unfolded and prone to form pathological aggregates associated with neurodegeneration. How do neurons protect from those insults and remain healthy for their whole life? Ali and colleagues now present a molecular mechanism by which the enzyme nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) acts not only as a NAD synthase involved in axonal maintenance but as a molecular chaperone helping neurons to overcome protein unfolding and protein aggregation.
authors.affiliation: Instituto de Biomedicina de Sevilla (IBiS) HUVR/CSIC/Universidad de Sevilla, Departamento de Fisiología Médica y Biofísica and CIBERNED, Seville, Spain.
authors.forename: Angela
authors.identifier: 0000-0003-1281-9139
authors.initials: A
authors.lastname: Lavado-Roldán
authors.affiliation: Instituto de Biomedicina de Sevilla (IBiS) HUVR/CSIC/Universidad de Sevilla, Departamento de Fisiología Médica y Biofísica and CIBERNED, Seville, Spain.
authors.forename: Rafael
authors.identifier: 0000-0002-9845-9885
authors.initials: R
authors.lastname: Fernández-Chacón
mesh_terms: D001369:Axons; D003712:Dendrites; D018832:Molecular Chaperones; D009243:NAD; D009474:Neurons; D009612:Nicotinamide-Nucleotide Adenylyltransferase
chemical_list: D018832:Molecular Chaperones; D009243:NAD; D009612:Nicotinamide-Nucleotide Adenylyltransferase