title: Protective effect of green tea against neuro-functional alterations in rats treated with MnO2nanoparticles.
abstract: BACKGROUND
  Inhalation of manganese-containing metal fumes at workplaces can cause central nervous damage including a Parkinson-like syndrome. Oxidative stress is likely to be involved in the pathomechanism, due to the presence of nano-sized metal oxide particles with high biological and chemical activity. Oxidative damage of the nervous system could be prevented or ameliorated by properly applied antioxidants, preferably natural ones such as green tea, a popular drink. The aim of this work was to see if orally applied green tea brew could diminish the functional neurotoxicity of manganese dioxide nanoparticles introduced into the airways of rats.
  
  
  RESULTS
  Young adult male Wistar rats were treated intratracheally for 6 weeks with a suspension of synthetic MnO2nanoparticles (4 mg/kg body weight), and received green tea brew (1 g leaves 200 mL-1water) as drinking fluid. Reduced body weight gain, indicating general toxicity of the nanoparticles, was not influenced by green tea. However, in rats receiving green tea the nervous system effects - changes in the spontaneous and evoked cortical activity and peripheral nerve action potential - were diminished.
  
  
  CONCLUSIONS
  The use of green tea as a neuroprotective functional drink seems to be a viable approach. © 2016 Society of Chemical Industry.
authors.affiliation: Department of Public Health, University of Szeged Faculty of Medicine, Szeged, Hungary.
authors.forename: Kitti
authors.initials: K
authors.lastname: Sárközi
authors.affiliation: Department of Public Health, University of Szeged Faculty of Medicine, Szeged, Hungary.
authors.forename: András
authors.identifier: http://orcid.org/0000-0003-0485-0806
authors.initials: A
authors.lastname: Papp
authors.affiliation: Department of Public Health, University of Szeged Faculty of Medicine, Szeged, Hungary.
authors.forename: Edina
authors.initials: E
authors.lastname: Horváth
authors.affiliation: Department of Public Health, University of Szeged Faculty of Medicine, Szeged, Hungary.
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Máté
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Szeged Faculty of Science and Informatics, Szeged, Hungary.
authors.forename: Edit
authors.initials: E
authors.lastname: Hermesz
authors.affiliation: Department of Applied and Environmental Chemistry, University of Szeged Faculty of Science and Informatics, Szeged, Hungary.
authors.forename: Gábor
authors.initials: G
authors.lastname: Kozma
authors.affiliation: Department of Pharmacognosy, University of Szeged Faculty of Pharmacy, Szeged, Hungary.
authors.forename: Zoltán Péter
authors.initials: ZP
authors.lastname: Zomborszki
authors.affiliation: Department of Inorganic and Analytical Chemistry, University of Szeged Faculty of Science and Informatics, Szeged, Hungary.
authors.forename: Ildikó
authors.initials: I
authors.lastname: Kálomista
authors.affiliation: Department of Inorganic and Analytical Chemistry, University of Szeged Faculty of Science and Informatics, Szeged, Hungary.
authors.forename: Gábor
authors.initials: G
authors.lastname: Galbács
authors.affiliation: Department of Public Health, University of Szeged Faculty of Medicine, Szeged, Hungary.
authors.forename: Andrea
authors.initials: A
authors.lastname: Szabó
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000378:metabolism; D002493:Central Nervous System Diseases / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D006801:Humans; D008297:Male; D017895:Manganese Compounds; D053758:Nanoparticles / Q000633:toxicity*; D009420:Nervous System / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D018384:Oxidative Stress / Q000187:drug effects; D010087:Oxides / Q000633:toxicity*; D010936:Plant Extracts / Q000008:administration & dosage / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013662:Tea / Q000737:chemistry / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D017895:Manganese Compounds; D010087:Oxides; D010936:Plant Extracts; D013662:Tea; C016552:manganese dioxide
keywords: antioxidant; cortical and peripheral electrical activity; neurotoxicity; oxidative damage; protection