title: Phospholipids and glycolipids mediate proton containment and circulation along the surface of energy-transducing membranes.
abstract: Proton bioenergetics provides the energy for growth and survival of most organisms in the biosphere ranging from unicellular marine phytoplankton to humans. Chloroplasts harvest light and generate a proton electrochemical gradient (proton motive force) that drives the production of ATP needed for carbon dioxide fixation and plant growth. Mitochondria, bacteria and archaea generate proton motive force to energize growth and other physiologies. Energy transducing membranes are at the heart of proton bioenergetics and are responsible for catalyzing the conversion of energy held in high-energy electrons→electron transport chain→proton motive force→ATP. Whereas the electron transport chain is understood in great detail there are major gaps in understanding mechanisms of proton transfer or circulation during proton bioenergetics. This paper is built on the proposition that phospho- and glyco-glycerolipids form proton transport circuitry at the membrane's surface. By this proposition, an emergent membrane property, termed the hyducton, confines active/unbound protons or hydronium ions to a region of low volume close to the membrane surface. In turn, a von Grotthuß mechanism rapidly moves proton substrate in accordance with nano-electrochemical poles on the membrane surface created by powerful proton pumps such as ATP synthase.
authors.affiliation: University of Bremen, MARUM - Center for Marine and Environmental Sciences, Germany. Electronic address: marcosyukio@gmail.com.
authors.forename: Marcos Y
authors.initials: MY
authors.lastname: Yoshinaga
authors.affiliation: University of California Santa Barbara - Department of Earth Science and Marine Science Institute, USA.
authors.forename: Matthias Y
authors.initials: MY
authors.lastname: Kellermann
authors.affiliation: University of California Santa Barbara - Department of Earth Science and Marine Science Institute, USA.
authors.forename: David L
authors.initials: DL
authors.lastname: Valentine
authors.affiliation: University of California Davis, USA.
authors.forename: Raymond C
authors.initials: RC
authors.lastname: Valentine
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D001105:Archaea / Q000378:metabolism; D001419:Bacteria / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D002736:Chloroplasts / Q000378:metabolism; D004734:Energy Metabolism; D006017:Glycolipids / Q000378:metabolism*; D021962:Membrane Microdomains / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism*; D018892:Proton-Motive Force
chemical_list: D006017:Glycolipids; D010743:Phospholipids; D000255:Adenosine Triphosphate
keywords: Energy transducing membranes; Glycerolipids; Glycolipids; Long distance proton transport; Phospholipids; Proton bioenergetics; von Grotthuß mechanism