title: Association of genetic polymorphisms of IL1β -511 C>T, IL1RN VNTR 86 bp, IL6 -174 G>C, IL10 -819 C>T and TNFα -308 G>A, involved in symptomatic patients with dengue in Brazil.
abstract: OBJECTIVE
  In this study, single nucleotide polymorphisms (SNP) of interleukin (IL) 1β -511C>T, IL1RN VNTR 86 bp, IL6 -174G>C, IL10 -819C>T and TNFα -308G>A were analyzed by PCR-RFLP with symptoms of dengue with the clinical features.
  
  
  METHODS
  196 individuals admitted to the São José Infectious Diseases Hospital with suspected dengue infection. Dengue was confirmed in 111 of the patients. The control group consisted of 85 other individuals confirmed without dengue.
  
  
  RESULTS
  It was demonstrated that the presence the T allele of IL1β (P < 0.05) was associated with susceptibility to developing the disease. Other results also suggested that the polymorphism in the combinations IL6 × IL1β (C and T alleles, respectively), IL1β (T allele) × IL1RN (*2/*2 genotype), IL6 (C allele) × TNFα (A allele), IL10 (C/T genotype) × TNFα (A/A genotype) (P < 0.01, P = 0.01, P < 0.05 and P = 0.03, respectively) were associated with predisposition to developing the disease and its symptoms.
  
  
  CONCLUSIONS
  In summary, the findings of this study in a Brazilian population point out the importance of studies of combinations of polymorphisms in the development of dengue, which can increase the risk of dengue infection and its severity.
authors.affiliation: Medicine Collegiate, Federal University of San Francisco Valley, Paulo Afonso, Bahia, Brazil. isaac.farias@univasf.edu.br.|Centro de Treinamento Profissional de Paulo Afonso (CFPPA), Rua Aurora, Bloco 27, Lote 3, Bairro Alves de Souza, Paulo Afonso, Brazil. isaac.farias@univasf.edu.br.
authors.forename: Isaac Farias
authors.initials: IF
authors.lastname: Cansanção
authors.affiliation: Molecular Genetics Laboratory, Department of Pathology and Forensic Medicine, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.|, Rua Coronel Nunes de Melo, 1315, Bairro Rodolfo Teófilo, Fortaleza, Brazil.
authors.forename: Ana Paula Santos
authors.initials: AP
authors.lastname: do Carmo
authors.affiliation: São José Hospital of Infectious Diseases, Fortaleza, Ceará, Brazil.|, Rua Nestor Barbosa, 315, Bairro Parquelândia, Fortaleza, Brazil.
authors.forename: Robério Dias
authors.initials: RD
authors.lastname: Leite
authors.affiliation: Molecular Genetics Laboratory, Department of Pathology and Forensic Medicine, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.|, Rua Coronel Nunes de Melo, 1315, Bairro Rodolfo Teófilo, Fortaleza, Brazil.
authors.forename: Rosana Deyse Ponte
authors.initials: RD
authors.lastname: Portela
authors.affiliation: Genetics Department, Laboratory of Bioinformatics and Evolutionary Biology, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
authors.forename: Sérgio
authors.initials: S
authors.lastname: de Sá Leitão Paiva Júnior
authors.affiliation: Genetics Department, Laboratory of Bioinformatics and Evolutionary Biology, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
authors.forename: Valdir
authors.initials: V
authors.lastname: de Queiroz Balbino
authors.affiliation: Molecular Genetics Laboratory, Department of Pathology and Forensic Medicine, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.|, Rua Coronel Nunes de Melo, 1315, Bairro Rodolfo Teófilo, Fortaleza, Brazil.
authors.forename: Silvia Helena Barem
authors.initials: SH
authors.lastname: Rabenhorst
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001938:Brazil; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000235:genetics*; D003715:Dengue / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007223:Infant; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D016207:Cytokines; C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein
keywords: Dengue; Interleukin polymorphism; Non-dengue infection; Risk