title: Retinal Capillary Network and Foveal Avascular Zone in Eyes with Vein Occlusion and Fellow Eyes Analyzed With Optical Coherence Tomography Angiography.
abstract: To evaluate the perifoveolar retinal capillary network at different depths and to quantify the foveal avascular zone (FAZ) in eyes with retinal vein occlusion (RVO) compared with their fellow eyes and healthy controls using spectral-domain optical coherence tomography angiography (SD-OCTA).
  
  
  
  We prospectively recruited 23 patients with RVO including 15 eyes with central RVO (CRVO) and 8 eyes with branch RVO (BRVO), their fellow eyes, and 8 age-matched healthy controls (8 eyes) for imaging on prototype OCTA software within RTVue-XR Avanti. The 3 × 3 mm and 6 × 6 mm en face angiograms of superficial and deep retinal capillary plexuses were segmented. Perifoveolar retinal capillary network was analyzed and FAZ was quantified.
  
  
  
  Decrease in vascular perfusion at the deep plexus was observed in all eyes with CRVO (8/8, 100%) and BRVO (6/6, 100%) without cystoid macular edema, and in 8 of 15 (53%) and 2 of 8 (25%) of the fellow eyes, respectively. Vascular tortuosity was observed in 13 of 15 (87%) CRVO and 5 of 8 (63%) BRVO eyes. Collaterals were seen in 10 of 15 (67%) CRVO and 5 of 8 (63%) BRVO eyes. Mean FAZ area was larger in eyes with RVO than their fellow eyes (1.13 ± 0.25 mm2 versus 0.58 ± 0.28 mm2; P = 0.007) and controls (1.13 ± 0.25 mm2 versus 0.30 ± 0.09 mm2; P < 0.0001), and in fellow eyes of RVO patients when compared to controls (0.58 ± 0.28 mm2 versus 0.30 ± 0.09 mm2; P = 0.01).
  
  
  
  Spectral-domain OCTA reveals abnormalities at different levels of perifoveolar retinal capillary network and is able to quantify the FAZ in RVO. Longitudinal studies may be considered to evaluate the clinical utility of OCTA in RVO and other retinal vascular diseases.
authors.affiliation: New England Eye Center Tufts University School of Medicine, Boston, Massachusetts, United States 2Departments of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachu.
authors.forename: Mehreen
authors.initials: M
authors.lastname: Adhi
authors.affiliation: New England Eye Center Tufts University School of Medicine, Boston, Massachusetts, United States 3CAPES Foundation, Ministry of Education of Brazil, Brasilia, Distrito Federal, Brazil.
authors.forename: Marco A Bonini
authors.initials: MA
authors.lastname: Filho
authors.affiliation: New England Eye Center Tufts University School of Medicine, Boston, Massachusetts, United States 3CAPES Foundation, Ministry of Education of Brazil, Brasilia, Distrito Federal, Brazil 4Ophthalmic Center Reference (CEROF), Federal University of Goiás, Goiâ
authors.forename: Ricardo N
authors.initials: RN
authors.lastname: Louzada
authors.affiliation: Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States 6Doheny Eye Institute, Los Angeles, California, United States.
authors.forename: Laura
authors.initials: L
authors.lastname: Kuehlewein
authors.affiliation: New England Eye Center Tufts University School of Medicine, Boston, Massachusetts, United States 2Departments of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachu.
authors.forename: Talisa E
authors.initials: TE
authors.lastname: de Carlo
authors.affiliation: New England Eye Center Tufts University School of Medicine, Boston, Massachusetts, United States.
authors.forename: Caroline R
authors.initials: CR
authors.lastname: Baumal
authors.affiliation: New England Eye Center Tufts University School of Medicine, Boston, Massachusetts, United States.
authors.forename: Andre J
authors.initials: AJ
authors.lastname: Witkin
authors.affiliation: Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States 6Doheny Eye Institute, Los Angeles, California, United States.
authors.forename: Srinivas R
authors.initials: SR
authors.lastname: Sadda
authors.affiliation: Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States 7Stein Eye Institute, Los Angeles, California, United States 8Greater Los Angeles VA Healthcare Center, Los Angeles, California, United States.
authors.forename: David
authors.initials: D
authors.lastname: Sarraf
authors.affiliation: New England Eye Center Tufts University School of Medicine, Boston, Massachusetts, United States.
authors.forename: Elias
authors.initials: E
authors.lastname: Reichel
authors.affiliation: New England Eye Center Tufts University School of Medicine, Boston, Massachusetts, United States.
authors.forename: Jay S
authors.initials: JS
authors.lastname: Duker
authors.affiliation: New England Eye Center Tufts University School of Medicine, Boston, Massachusetts, United States.
authors.forename: Nadia K
authors.initials: NK
authors.lastname: Waheed
mesh_terms: D000368:Aged; D002196:Capillaries / Q000473:pathology; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods*; D005500:Follow-Up Studies; D005584:Fovea Centralis / Q000473:pathology*; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000502:physiology*; D008875:Middle Aged; D011446:Prospective Studies; D012039:Regional Blood Flow / Q000502:physiology*; D012170:Retinal Vein Occlusion / Q000175:diagnosis* / Q000503:physiopathology; D012171:Retinal Vessels / Q000473:pathology / Q000503:physiopathology*; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity