title: Symptomatic Congenital Hemangioma and Congenital Hemangiomatosis Associated With a Somatic Activating Mutation in GNA11.
abstract: Congenital hemangiomas are uncommon benign vascular tumors that present fully formed at birth. They are rarely associated with transient hematologic abnormalities, which are typically less severe than the Kasabach-Merritt phenomenon associated with kaposiform hemangioendotheliomas. Congenital hemangiomas are typically solitary and have not been reported to occur in a multifocal, generalized pattern.
  
  
  
  To describe a male infant born with an unusual, large vascular mass complicated by anemia, thrombocytopenia, and disseminated intravascular coagulopathy, as well as innumerable small vascular papules in a generalized cutaneous distribution.
  
  
  
  This case report is a descriptive observation of the results of clinical, pathologic, and genetic studies performed in a single male infant observed for 2 years (May 2013 to June 2015) for vascular anomalies at a tertiary care referral center.
  
  
  
  Histopathologic, immunohistochemical, and genetic study results of tumor specimens and saliva.
  
  
  
  Careful pathologic study of 3 tumor specimens revealed similar lobular proliferations of bland endothelial cells. Lesional vessels did not express GLUT1 or the lymphatic marker D2-40, whereas WT1 was expressed. A somatic c.A626C, p.Q209P mutation in the GNA11 gene was identified in tumoral tissue.
  
  
  
  These findings support a unifying diagnosis of congenital hemangioma for these vascular tumors. To date, this is the first-reported case of a hemangiomatosis presentation of congenital hemangioma. In addition to highlighting this novel phenotype, this case indicates the rare association of congenital hemangioma with hematologic abnormalities and verifies somatic activating mutations as the underlying cause of congenital hemangioma.
authors.affiliation: Department of Dermatology, Oregon Health & Science University, Portland.
authors.forename: Tracy
authors.initials: T
authors.lastname: Funk
authors.affiliation: Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut3Department of Genetics, Yale University School of Medicine, New Haven, Connecticut4Department of Pathology, Yale University School of Medicine, New Haven, Connecticut.
authors.forename: Young
authors.initials: Y
authors.lastname: Lim
authors.affiliation: Division of Pediatric General, Thoracic, and Fetal Surgery, Department of Surgery, University of Colorado School of Medicine, Aurora.
authors.forename: Ann M
authors.initials: AM
authors.lastname: Kulungowski
authors.affiliation: Department of Dermatology, University of Colorado School of Medicine, Aurora7Department of Pathology, University of Colorado School of Medicine, Aurora.
authors.forename: Lori
authors.initials: L
authors.lastname: Prok
authors.affiliation: Division of Pediatric General, Thoracic, and Fetal Surgery, Department of Surgery, University of Colorado School of Medicine, Aurora.
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Crombleholme
authors.affiliation: Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut3Department of Genetics, Yale University School of Medicine, New Haven, Connecticut4Department of Pathology, Yale University School of Medicine, New Haven, Connecticut.
authors.forename: Keith
authors.initials: K
authors.lastname: Choate
authors.affiliation: Department of Dermatology, University of Colorado School of Medicine, Aurora8Department of Pediatrics, University of Colorado School of Medicine, Aurora.
authors.forename: Anna L
authors.initials: AL
authors.lastname: Bruckner
mesh_terms: D000740:Anemia / Q000209:etiology; D002675:Child, Preschool; D004211:Disseminated Intravascular Coagulation / Q000209:etiology; D044385:GTP-Binding Protein alpha Subunits / Q000235:genetics*; D006391:Hemangioma / Q000150:complications / Q000151:congenital / Q000235:genetics*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009154:Mutation; D009378:Neoplasms, Multiple Primary / Q000150:complications / Q000151:congenital / Q000235:genetics*; D012878:Skin Neoplasms / Q000150:complications / Q000151:congenital / Q000235:genetics*; D013921:Thrombocytopenia / Q000209:etiology
chemical_list: C554062:GNA11 protein, human; D044385:GTP-Binding Protein alpha Subunits