title: Polyautoimmunity in Sjögren Syndrome.
abstract: Polyautoimmunity is defined as the presence of more than one well-defined autoimmune disease (AD) in a single patient. Polyautoimmunity is a frequent condition in Sjögren syndrome (SS) and follows a grouping pattern. The most frequent ADs observed in SS are autoimmune thyroid disease, rheumatoid arthritis, and systemic lupus erythematosus. Main factors associated with polyautoimmunity in SS are tobacco smoking and some genetic variants. The study of polyautoimmunity provides important clues for elucidating the common mechanisms of autoimmne diseases (ie, the autoimmune tautology).
authors.affiliation: Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Carrera 26 No. 63B-51, Bogotá 111221, Colombia. Electronic address: anayajm@gmail.com.
authors.forename: Juan-Manuel
authors.initials: JM
authors.lastname: Anaya
authors.affiliation: Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Carrera 26 No. 63B-51, Bogotá 111221, Colombia.
authors.forename: Adriana
authors.initials: A
authors.lastname: Rojas-Villarraga
authors.affiliation: Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Carrera 26 No. 63B-51, Bogotá 111221, Colombia.
authors.forename: Ruben D
authors.initials: RD
authors.lastname: Mantilla
authors.affiliation: Genomics and Predictive Medicine, Genome Biology Department, John Curtin School of Medical Research, ANU College of Medicine, Biology and Environment, The Australian National University, ACT, Garrand Road, Canberra 2600, Australia.
authors.forename: Mauricio
authors.initials: M
authors.lastname: Arcos-Burgos
authors.affiliation: Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Carrera 26 No. 63B-51, Bogotá 111221, Colombia.
authors.forename: Juan Camilo
authors.initials: JC
authors.lastname: Sarmiento-Monroy
mesh_terms: D001172:Arthritis, Rheumatoid / Q000453:epidemiology / Q000235:genetics / Q000276:immunology; D001327:Autoimmune Diseases / Q000453:epidemiology* / Q000235:genetics / Q000276:immunology; D015551:Autoimmunity / Q000276:immunology; D015897:Comorbidity; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology / Q000235:genetics / Q000276:immunology; D012859:Sjogren's Syndrome / Q000453:epidemiology* / Q000235:genetics / Q000276:immunology; D012907:Smoking / Q000453:epidemiology; D013967:Thyroiditis, Autoimmune / Q000453:epidemiology / Q000235:genetics / Q000276:immunology
keywords: Autoimmune tautology; Polyautoimmunity; Sjögren syndrome