title: [PECULIARITIES OF THE CEREBROVASCULAR EFFECTS OF GLUTAMIC ACID].
abstract: Experiments on nonlinear rats subjected to global transient cerebral ischemia revealed the ability of glutamic acid to improve cerebral circulation. Consequently, the excitatory amino acid can produce adverse (neurotoxic) and positive (anti-ischemic) effects in cerebral ischemia. The cerebrovascular effect of glutamic acid in cerebral ischemia is attenuated on the background action of the MNDA receptor blocker MK-801 (0.5 mg/kg intravenously) and eliminated by bicuculline. When glutamic acid is combined with the non-competitive MNDA receptor antagonist MK-801, neither one nor another drug shows its vasodilator effect. The results are indicative of the interaction between excitatory and inhibitory systems on the level of cerebral vessels and once again confirm our previous conclusion about the decisive role of GABA(A) receptors in brain vessels in the implementation of anti-ischemic activity of endogenous compounds (melatonin) and well-known pharmacological substances (mexidol, afobazole), and new chemical compounds based on GABA-containing lipid derivatives.
authors.forename: T S
authors.initials: TS
authors.lastname: Gan'shina
authors.forename: E V
authors.initials: EV
authors.lastname: Kurza
authors.forename: I N
authors.initials: IN
authors.lastname: Kurdyumov
authors.forename: D V
authors.initials: DV
authors.lastname: Maslennikov
authors.forename: R S
authors.initials: RS
authors.lastname: Mirzoyan
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D001640:Bicuculline / Q000494:pharmacology; D002545:Brain Ischemia / Q000188:drug therapy* / Q000473:pathology; D017536:Carotid Artery, Common / Q000601:surgery; D002560:Cerebrovascular Circulation / Q000187:drug effects; D054059:Coronary Occlusion / Q000473:pathology; D016291:Dizocilpine Maleate / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D058787:GABA-A Receptor Antagonists / Q000494:pharmacology; D018698:Glutamic Acid / Q000494:pharmacology*; D008297:Male; D018696:Neuroprotective Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D011963:Receptors, GABA-A / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D018691:Excitatory Amino Acid Antagonists; D058787:GABA-A Receptor Antagonists; D018696:Neuroprotective Agents; D011963:Receptors, GABA-A; D016194:Receptors, N-Methyl-D-Aspartate; D018698:Glutamic Acid; D016291:Dizocilpine Maleate; D001640:Bicuculline