title: Chemoselective acylation of benzimidazoles with phenylacetic acids under different Cu catalysts to give fused five-membered N-heterocycles or tertiary amides.
abstract: C-N bond formation via a copper-catalyzed aerobic oxidative decarboxylative tandem protocol was realized. The phenylacetic acids which contain ortho-X (X = F or Br) on the aromatic ring will render a fused five-membered heterocycle via a tandem aromatic nucleophilic substitution and aerobic oxidative decarboxylative acylation at the C(sp(2))-H bond of benzimidazoles under the Cu(OAc)2/K2CO3/BF3·Et2O catalytic system, while with CuBr as the catalyst and pyridine as the base, N-acylation occurred and tertiary amides were obtained.
authors.affiliation: Institute of Next Generation Matter Transformation, College of Chemical Engineering at Huaqiao University, China. qsong@hqu.edu.cn.
authors.forename: Shaoyu
authors.initials: S
authors.lastname: Mai
authors.forename: Yingwei
authors.initials: Y
authors.lastname: Zhao
authors.forename: Qiuling
authors.initials: Q
authors.lastname: Song