title: [Clinical Application of Non-invasive Diagnostic Tests for Liver Fibrosis].
abstract: The diagnostic assessment of liver fibrosis is an important step in the management of patients with chronic liver diseases. Liver biopsy is considered the gold standard to assess necroinflammation and fibrosis. However, recent technical advances have introduced numerous serum biomarkers and imaging tools using elastography as noninvasive alternatives to biopsy. Serum markers can be direct or indirect markers of the fibrosis process. The elastography-based studies include transient elastography, acoustic radiation force imaging, supersonic shear wave imaging and magnetic resonance elastography. As accumulation of clinical data shows that noninvasive tests provide prognostic information of clinical relevance, non-invasive diagnostic tools have been incorporated into clinical guidelines and practice. Here, the authors review noninvasive tests for the diagnosis of liver fibrosis.
authors.affiliation: Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
authors.forename: Jung Woo
authors.initials: JW
authors.lastname: Shin
authors.affiliation: Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
authors.forename: Neung Hwa
authors.initials: NH
authors.lastname: Park
mesh_terms: D015415:Biomarkers / Q000097:blood; D024061:Collagen Type III / Q000097:blood; D054459:Elasticity Imaging Techniques; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood; D008103:Liver Cirrhosis / Q000175:diagnosis* / Q000000981:diagnostic imaging; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood; D014463:Ultrasonography
chemical_list: D015415:Biomarkers; D024061:Collagen Type III; D019715:Tissue Inhibitor of Metalloproteinase-1; D006820:Hyaluronic Acid
keywords: Diagnosis; Fibrosis; Liver