title: Labial Salivary Glands in Infants: Histochemical Analysis of Cytoskeletal and Antimicrobial Proteins.
abstract: Human labial glands secrete mucous and serous substances for maintaining oral health. The normal microbial flora of the oral cavity is regulated by the acquired and innate immune systems. The localization and distribution of proteins of the innate immune system were investigated in serous acinar cells and the ductal system by the method of immunohistochemistry. Numerous antimicrobial proteins could be detected in the labial glands: β-defensin-1, -2, -3; lysozyme; lactoferrin; and cathelicidin. Cytoskeletal components such as actin, myosin II, cytokeratins 7 and 19, α- and β-tubulin were predominantly observed in apical cell regions and may be involved in secretory activities.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Technical University of Munich, Munich, Germany (MS, DJL, SK, MRK)
authors.forename: Mechthild
authors.initials: M
authors.lastname: Stoeckelhuber
authors.affiliation: Department of Oral and Maxillofacial Surgery, Technical University of Munich, Munich, Germany (MS, DJL, SK, MRK)
authors.forename: Denys J
authors.initials: DJ
authors.lastname: Loeffelbein
authors.affiliation: Department of Otorhinolaryngology, Ludwig Maximilians University of Munich, Munich, Germany (BO)
authors.forename: Bernhard
authors.initials: B
authors.lastname: Olzowy
authors.affiliation: Department of Neuroanatomy, Ludwig Maximilians University of Munich, Munich, Germany (CS)
authors.forename: Christoph
authors.initials: C
authors.lastname: Schmitz
authors.affiliation: Department of Oral and Maxillofacial Surgery, Technical University of Munich, Munich, Germany (MS, DJL, SK, MRK)
authors.forename: Steffen
authors.initials: S
authors.lastname: Koerdt
authors.affiliation: Department of Oral and Maxillofacial Surgery, Technical University of Munich, Munich, Germany (MS, DJL, SK, MRK)
authors.forename: Marco R
authors.initials: MR
authors.lastname: Kesting
mesh_terms: D000199:Actins / Q000032:analysis*; D023181:Antimicrobial Cationic Peptides / Q000032:analysis*; D002675:Child, Preschool; D003598:Cytoskeletal Proteins / Q000032:analysis*; D023082:Defensins / Q000032:analysis; D005260:Female; D006801:Humans; D007223:Infant; D007781:Lactoferrin / Q000032:analysis; D008046:Lip; D008297:Male; D009113:Muramidase / Q000032:analysis; D012469:Salivary Glands / Q000737:chemistry*; D054804:Cathelicidins
chemical_list: D000199:Actins; D023181:Antimicrobial Cationic Peptides; D003598:Cytoskeletal Proteins; D023082:Defensins; D009113:Muramidase; D007781:Lactoferrin; D054804:Cathelicidins
keywords: antimicrobial proteins; cytoskeleton; human labial gland; immunohistochemistry; minor salivary gland