title: The relative contributions of psychiatric symptoms and psychotropic medications on the sleep-wake profile of young persons with anxiety, depression and bipolar disorders.
abstract: This study investigated the relative contribution of psychiatric symptoms and psychotropic medications on the sleep-wake cycle. Actigraphy and clinical assessments (Brief Psychiatric Rating Scale) were conducted in 146 youths with anxiety, depression or bipolar disorders. Independently of medications, mania symptoms were predictive of lower circadian amplitude and rhythmicity. Independently of diagnosis and symptoms severity: i) antipsychotics were related to longer sleep period and duration, ii) serotonin-norepinephrine reuptake inhibitors to longer sleep period, and iii) agomelatine to earlier sleep onset. Manic symptoms and different subclasses of medications may have independent influences on the sleep-wake cycle of young people with mental disorders.
authors.affiliation: Clinical Research Unit, Brain & Mind Research Institute, University of Sydney, Camperdown, NSW 2050, Australia. Electronic address: Rebecca.Robillard@theroyal.ca.
authors.forename: Rébecca
authors.initials: R
authors.lastname: Robillard
authors.affiliation: Clinical Research Unit, Brain & Mind Research Institute, University of Sydney, Camperdown, NSW 2050, Australia.
authors.forename: Cristal
authors.initials: C
authors.lastname: Oxley
authors.affiliation: Clinical Research Unit, Brain & Mind Research Institute, University of Sydney, Camperdown, NSW 2050, Australia.
authors.forename: Daniel F
authors.initials: DF
authors.lastname: Hermens
authors.affiliation: Clinical Research Unit, Brain & Mind Research Institute, University of Sydney, Camperdown, NSW 2050, Australia.
authors.forename: Django
authors.initials: D
authors.lastname: White
authors.affiliation: Clinical Research Unit, Brain & Mind Research Institute, University of Sydney, Camperdown, NSW 2050, Australia.
authors.forename: Ryan
authors.initials: R
authors.lastname: Wallis
authors.affiliation: Clinical Research Unit, Brain & Mind Research Institute, University of Sydney, Camperdown, NSW 2050, Australia; School of Psychology, University of Sydney, Camperdown, NSW 2050, Australia.
authors.forename: Sharon L
authors.initials: SL
authors.lastname: Naismith
authors.affiliation: Clinical Research Unit, Brain & Mind Research Institute, University of Sydney, Camperdown, NSW 2050, Australia.
authors.forename: Bradley
authors.initials: B
authors.lastname: Whitwell
authors.affiliation: Clinical Research Unit, Brain & Mind Research Institute, University of Sydney, Camperdown, NSW 2050, Australia.
authors.forename: James
authors.initials: J
authors.lastname: Southan
authors.affiliation: Clinical Research Unit, Brain & Mind Research Institute, University of Sydney, Camperdown, NSW 2050, Australia.
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Scott
authors.affiliation: Clinical Research Unit, Brain & Mind Research Institute, University of Sydney, Camperdown, NSW 2050, Australia. Electronic address: ian.hickie@sydney.edu.au.
authors.forename: Ian B
authors.initials: IB
authors.lastname: Hickie
mesh_terms: D056044:Actigraphy / Q000379:methods; D000293:Adolescent; D000328:Adult; D001007:Anxiety / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D001714:Bipolar Disorder / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D003863:Depression / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D011619:Psychotropic Drugs / Q000494:pharmacology*; D012890:Sleep / Q000187:drug effects* / Q000502:physiology; D012893:Sleep Wake Disorders / Q000523:psychology; D055815:Young Adult
chemical_list: D011619:Psychotropic Drugs
keywords: Actigraphy; Affective disorders; Pharmacotherapy