title: Advances in immunotherapy for melanoma management.
abstract: Melanoma remains a leading cause of death among young adults. Evidence that melanoma tumor cells are highly immunogenic and a better understanding of T-cell immune checkpoints have changed the therapeutic approach to advanced melanoma. Instead of targeting the tumor directly, immunotherapy targets and activates the immune response using checkpoint inhibitors, monoclonal antibodies, vaccines, and adoptive T cell therapy. This review focuses on the immune signaling and biological mechanisms of action of recent immune-based melanoma therapies as well as their clinical benefits.
authors.affiliation: a Department of Dermatology and Dermatologic Surgery , Medical University of South Carolina , Charleston , SC , USA.|b Hollings Cancer Center, Medical University of South Carolina , Charleston , SC , USA.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Dany
authors.affiliation: b Hollings Cancer Center, Medical University of South Carolina , Charleston , SC , USA.
authors.forename: Rose
authors.initials: R
authors.lastname: Nganga
authors.affiliation: b Hollings Cancer Center, Medical University of South Carolina , Charleston , SC , USA.
authors.forename: Alissar
authors.initials: A
authors.lastname: Chidiac
authors.affiliation: b Hollings Cancer Center, Medical University of South Carolina , Charleston , SC , USA.
authors.forename: Edith
authors.initials: E
authors.lastname: Hanna
authors.affiliation: b Hollings Cancer Center, Medical University of South Carolina , Charleston , SC , USA.
authors.forename: Sara
authors.initials: S
authors.lastname: Matar
authors.affiliation: a Department of Dermatology and Dermatologic Surgery , Medical University of South Carolina , Charleston , SC , USA.
authors.forename: Dirk
authors.initials: D
authors.lastname: Elston
mesh_terms: D019264:Adoptive Transfer; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D019496:Cancer Vaccines / Q000008:administration & dosage; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D008545:Melanoma / Q000628:therapy*
chemical_list: D000911:Antibodies, Monoclonal; D019496:Cancer Vaccines
keywords: checkpoint inhibitors; immunotherapy; melanoma; tumor immunology