title: Mild Cognitive Impairment and Risk of Critical Illness.
abstract: OBJECTIVE
  Approximately half of ICU admissions are comprised of patients older than 65 years old. Mild cognitive impairment is a common disorder affecting 10-20% of patients in the same age group. A need exists for exploring mild cognitive impairment and risk of critical illness. As mild cognitive impairment may be a contributor to poorer overall health or be a result of it, we sought to determine whether the presence of mild cognitive impairment independently increases the risk of critical illness admissions.
  
  
  METHODS
  Data from the Mayo Clinic Study of Aging were analyzed. All study participants underwent prospective comprehensive cognitive testing and expert panel consensus diagnosis of both cognitive function and clinical state at baseline and subsequent visits. Comparisons were made between those with normal cognitive function and mild cognitive impairment regarding baseline health and frequency of critical illness.
  
  
  METHODS
  Single-center population-based cohort out of Olmsted County, MN.
  
  
  METHODS
  All individuals 70-89 years old were screened for prospective enrollment in the Mayo Clinic Study of Aging. Patients with preexisting dementia and ICU admission within 3 years of entry to the study were excluded from this analysis.
  
  
  METHODS
  None.
  
  
  RESULTS
  Of 2,425 patients analyzed from the Mayo Clinic Study of Aging, 1,734 patients (71%) were included in the current study. Clinical factors associated with baseline mild cognitive impairment included age, male gender, stroke, and poorer health self-rating. Using a Cox regression model adjusting for these and a priori variables of baseline health, the presence of mild cognitive impairment remained a significant predictor of ICU admission (hazard ratio, 1.50 [1.15-1.96]; p = 0.003).
  
  
  CONCLUSIONS
  The presence of mild cognitive impairment is independently associated with increased critical illness admission. Further prospective studies are needed to analyze the impact of critical illness on cognitive function.
authors.affiliation: 1Department of Medicine, Mayo Clinic, Rochester, MN. 2Division of Pulmonary and Critical Care, Mayo Clinic, Rochester, MN. 3Department of Neurology, Mayo Clinic, Rochester, MN.
authors.forename: D Alex
authors.initials: DA
authors.lastname: Teeters
authors.forename: Teng
authors.initials: T
authors.lastname: Moua
authors.forename: Guangxi
authors.initials: G
authors.lastname: Li
authors.forename: Rahul
authors.initials: R
authors.lastname: Kashyap
authors.forename: Michelle
authors.initials: M
authors.lastname: Biehl
authors.forename: Rupinder
authors.initials: R
authors.lastname: Kaur
authors.forename: Ognjen
authors.initials: O
authors.lastname: Gajic
authors.forename: Bradley F
authors.initials: BF
authors.lastname: Boeve
authors.forename: Erik K
authors.initials: EK
authors.lastname: St Louis
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Petersen
authors.forename: Sean M
authors.initials: SM
authors.lastname: Caples
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D060825:Cognitive Dysfunction / Q000175:diagnosis / Q000453:epidemiology*; D016638:Critical Illness / Q000453:epidemiology*; D005260:Female; D006304:Health Status; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008910:Minnesota / Q000453:epidemiology; D010343:Patient Admission; D012737:Sex Factors; D020521:Stroke / Q000453:epidemiology