title: Primary Nasopharngeal Yolk Sac Tumor: A Case Report.
abstract: Yolk sac tumour also known as primitive endodermal tumour is the most common malignant germ cell tumour (GCT) in the paediatric age group. Most common sites of involvement are ovaries and testes, but rarely can occur in the extragonadal sites. In the head and neck region, yolk sac tumours have been reported in the nasopharynx, sinonasal tract, orbit, ear and parotid gland. Nasopharynx is an uncommon site for yolk sac tumour and very few cases of nasopharngeal pure yolk sac tumour have been reported so far. Yolk sac tumours are highly malignant and have a poor prognosis. This is a case of pure GCT in a three-year-old female child who presented with a rapidly growing nasopharyngeal mass. Histopathological examination followed by immunohistochemistry and serum AFP study clinched the diagnosis of yolk sac tumour. The tumour responded well to chemotherapy as evidenced by decrease in serum AFP levels.
authors.affiliation: Associate Professor, Department of Pathology, Coimbatore Medical College , Coimbatore, Tamil Nadu, India .
authors.forename: Dhanalakshmi
authors.initials: D
authors.lastname: Arumugam
authors.affiliation: Assistant Professor, Department of Pathology, Coimbatore Medical College , Coimbatore, Tamil Nadu, India .
authors.forename: Pavithra
authors.initials: P
authors.lastname: Thandavarayan
authors.affiliation: Assistant Professor, Department of Pathology, Coimbatore Medical College , Coimbatore, Tamil Nadu, India .
authors.forename: Lalitha
authors.initials: L
authors.lastname: Chidambaram
authors.affiliation: Assistant Professor, Department of Pathology, Coimbatore Medical College , Coimbatore, Tamil Nadu, India .
authors.forename: Sudha
authors.initials: S
authors.lastname: Boj
authors.affiliation: Assistant Professor, Department of Pathology, Coimbatore Medical College , Coimbatore, Tamil Nadu, India .
authors.forename: Sumathi
authors.initials: S
authors.lastname: Marudasalam
keywords: Alpha- fetoprotein; Germ cell tumours; Schiller –Duval bodies