title: Associations between the FKBP5 haplotype, exposure to violence and anxiety in females.
abstract: The gene that encodes the FK506-binding protein 5 (FKBP5) is regarded as a candidate for investigating how negative life events interact with a genetic predisposition to stress-related disorders, such as depression and anxiety. Given the role of FKBP5 as an important regulator of stress responses, we aimed to investigate if single-nucleotide polymorphisms (SNPs) in FKBP5-in the presence/absence of exposure to violence-are associated with symptoms of depression and anxiety. Data from two community-based samples of adolescents (n=1705) and young adults (n=1800) regarding ratings on depression, anxiety, exposure to violence and FKBP5 genotype were collected. A risk haplogenotype including the minor alleles of seven common SNPs in the FKBP5 (rs3800373, rs9296158, rs7748266, rs1360780, rs9394309, rs9470080 and rs4713916) conferred higher ratings on anxiety among females, but not males, in the presence of violence. Exposure to violence and female sex were associated with higher ratings on both depression and anxiety, with the exception of ratings on depression among young adults, on which sex had no effect. Ratings on depression were not associated with the haplogenotype. These findings may correspond to differences in the regulation of the HPA axis and with the higher vulnerability to anxiety in females.
authors.affiliation: Department of Neuroscience, Uppsala University, 751 85 Uppsala, Sweden; Department of Women's and Children's Health, Pediatric Neuropsychiatry Unit, Center for Neurodevelopmental Disorders at Karolinska Institutet (KIND), Karolinska Institutet, 171 77 Stockholm, Sweden. Electronic address: johan.isaksson@neuro.uu.se.
authors.forename: Johan
authors.initials: J
authors.lastname: Isaksson
authors.affiliation: Department of Neuroscience, Uppsala University, 751 85 Uppsala, Sweden.
authors.forename: Erika
authors.initials: E
authors.lastname: Comasco
authors.affiliation: Centre for Clinical Research, Västmanland County Hospital Västerås, Uppsala University, 721 89 Västerås, Sweden.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Åslund
authors.affiliation: Centre for Clinical Research, Västmanland County Hospital Västerås, Uppsala University, 721 89 Västerås, Sweden.
authors.forename: Mattias
authors.initials: M
authors.lastname: Rehn
authors.affiliation: Department of Psychology, University of Southern California, CA 90089-1061, USA; School of Law, Psychology and Social Work, Örebro University, 701 82 Örebro, Sweden.
authors.forename: Catherine
authors.initials: C
authors.lastname: Tuvblad
authors.affiliation: School of Law, Psychology and Social Work, Örebro University, 701 82 Örebro, Sweden.
authors.forename: Henrik
authors.initials: H
authors.lastname: Andershed
authors.affiliation: Centre for Clinical Research, Västmanland County Hospital Västerås, Uppsala University, 721 89 Västerås, Sweden.
authors.forename: Kent W
authors.initials: KW
authors.lastname: Nilsson
mesh_terms: D000293:Adolescent; D000328:Adult; D001007:Anxiety / Q000209:etiology / Q000235:genetics / Q000523:psychology; D003863:Depression / Q000209:etiology / Q000235:genetics / Q000523:psychology; D000069581:Exposure to Violence / Q000523:psychology*; D005260:Female; D006239:Haplotypes; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012737:Sex Factors; D022021:Tacrolimus Binding Proteins / Q000235:genetics*; D055815:Young Adult; D000099159:Tacrolimus Binding Protein 5
chemical_list: D022021:Tacrolimus Binding Proteins; D000099159:Tacrolimus Binding Protein 5
keywords: Anxiety; Depression; Exposure to violence; FKBP5; Sex differences