title: Asymmetric Catalytic Enantio- and Diastereoselective Boron Conjugate Addition Reactions of α-Functionalized α,β-Unsaturated Carbonyl Substrates.
abstract: An efficient catalytic system has been established for the asymmetric boron conjugate addition of B2pin2 onto α-functionalized (involving C, N, O, and Cl) α,β-unsaturated carbonyls under mild, neutral conditions involving Cu[(S)-(R)-ppfa]Cl, AgNTf2, and alcohols. The dual additives of AgNTf2 and alcohols were found to play crucial roles for achieving high catalytic activity and enantio- and diastereoselectivity (up to 98% ee and 70:1 dr).
authors.affiliation: Department of Chemistry and Biochemistry, Texas Tech University , Lubbock, Texas 79409-1061, United States.|New York University Abu Dhabi , P.O. Box 129188, Abu Dhabi, United Arab Emirates.
authors.forename: Jian-Bo
authors.initials: JB
authors.lastname: Xie
authors.affiliation: Department of Chemistry and Biochemistry, Texas Tech University , Lubbock, Texas 79409-1061, United States.
authors.forename: Siqi
authors.initials: S
authors.lastname: Lin
authors.affiliation: Department of Chemistry and Biochemistry, Texas Tech University , Lubbock, Texas 79409-1061, United States.
authors.forename: Shuo
authors.initials: S
authors.lastname: Qiao
authors.affiliation: Department of Chemistry and Biochemistry, Texas Tech University , Lubbock, Texas 79409-1061, United States.|Institute of Chemistry & BioMedical Sciences (ICBMS), Nanjing University , Nanjing 210093, People's Republic of China.
authors.forename: Guigen
authors.initials: G
authors.lastname: Li
mesh_terms: D001895:Boron / Q000737:chemistry*; D001896:Boron Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D001896:Boron Compounds; D007659:Ketones; D003300:Copper; D001895:Boron