title: Which cervical and endometrial cancer patients will benefit most from intensity-modulated proton therapy?
abstract: In this dosimetric comparison study it was shown that IMPT with robust planning reduces dose to surrounding organs in cervical and endometrial cancer treatment compared with IMRT. Especially for the para-aortic region, clinically relevant dose reductions were obtained for kidneys, spinal cord and bowel, justifying the use of proton therapy for this indication.
authors.affiliation: Department of Radiation Oncology, Leiden University Medical Center, The Netherlands.
authors.forename: Mariska A E
authors.initials: MA
authors.lastname: van de Sande
authors.affiliation: Department of Radiation Oncology, Leiden University Medical Center, The Netherlands. Electronic address: C.L.Creutzberg@lumc.nl.
authors.forename: Carien L
authors.initials: CL
authors.lastname: Creutzberg
authors.affiliation: Department of Radiation Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
authors.forename: Steven
authors.initials: S
authors.lastname: van de Water
authors.affiliation: Department of Radiation Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
authors.forename: Abdul Wahab
authors.initials: AW
authors.lastname: Sharfo
authors.affiliation: Department of Radiation Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
authors.forename: Mischa S
authors.initials: MS
authors.lastname: Hoogeman
mesh_terms: D016889:Endometrial Neoplasms / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D061766:Proton Therapy / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods*; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy*
keywords: Cervical cancer; Endometrial cancer; IMPT; IMRT; Treatment technique comparison