title: Synthesis and antimicrobial activity of styryl/pyrrolyl/pyrazolyl sulfonylmethyl-1,3,4-oxadiazolyl amines and styryl/pyrrolyl/pyrazolyl sulfonylmethyl-1,3,4-thiadiazolyl amines.
abstract: A new class of mono and bis heterocycles - styryl sulfonylmethyl-1,3,4-oxadiazolyl/1,3,4-thiadiazolyl amines, pyrrolyl sulfonylmethyl-1,3,4-oxadiazolyl/1,3,4-thiadiazolyl amines and pyrazolyl sulfonylmethyl-1,3,4-oxadiazolyl/1,3,4-thiadiazolyl amines were prepared from the synthetic intermediate Z-styrylsulfonylacetic acid adopting simple and well versed synthetic methodologies and studied their antimicrobial activity. Amongst all the tested compounds styryl thiadiazole 5c exhibited promising antimicrobial activity against Pseudomonas aeruginosa and Penicillium chrysogenum.
authors.affiliation: Department of Chemistry, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India.
authors.forename: G
authors.initials: G
authors.lastname: Sravya
authors.affiliation: Department of Chemistry, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India.
authors.forename: G
authors.initials: G
authors.lastname: Yamini
authors.affiliation: Department of Chemistry, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India.
authors.forename: V
authors.initials: V
authors.lastname: Padmavathi
authors.affiliation: Department of Chemistry, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India. Electronic address: advireddyp@yahoo.co.in.
authors.forename: A
authors.initials: A
authors.lastname: Padmaja
mesh_terms: D000588:Amines / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001234:Aspergillus niger / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic; D008826:Microbial Sensitivity Tests; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000588:Amines; D000890:Anti-Infective Agents; D010069:Oxadiazoles; D013830:Thiadiazoles
keywords: 1,3-Dipolar cycloaddition; Antimicrobial activity; Semicarbazide; Thiosemicarbazide