title: Zinc Levels in Left Ventricular Hypertrophy.
abstract: Zinc is one of the most important trace elements in the body and zinc homeostasis plays a critical role in maintaining cellular structure and function. Zinc dyshomeostasis can lead to many diseases, such as cardiovascular disease. Our aim was to investigate whether there is a relationship between zinc and left ventricular hypertrophy (LVH). A total of 519 patients was enrolled and their serum zinc levels were measured in this study. We performed analyses on the relationship between zinc levels and LVH and the four LV geometry pattern patients: normal LV geometry, concentric remodeling, eccentric LVH, and concentric LVH. We performed further linear and multiple regression analyses to confirm the relationship between zinc and left ventricular mass (LVM), left ventricular mass index (LVMI), and relative wall thickness (RWT). Our data showed that zinc levels were 710.2 ± 243.0 μg/L in the control group and were 641.9 ± 215.2 μg/L in LVH patients. We observed that zinc levels were 715 ± 243.5 μg/L, 694.2 ± 242.7 μg/L, 643.7 ± 225.0 μg/L, and 638.7 ± 197.0 μg/L in normal LV geometry, concentric remodeling, eccentric LVH, and concentric LVH patients, respectively. We further found that there was a significant inverse linear relationship between zinc and LVM (p = 0.001) and LVMI (p = 0.000) but did not show a significant relationship with RWT (p = 0.561). Multiple regression analyses confirmed that the linear relationship between zinc and LVM and LVMI remained inversely significant. The present study revealed that serum zinc levels were significantly decreased in the LVH patients, especially in the eccentric LVH and concentric LVH patients. Furthermore, zinc levels were significantly inversely correlated with LVM and LVMI.
authors.affiliation: Department of Cardiology, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin, 300052, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Huang
authors.affiliation: Department of Cardiology, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin, 300052, China.
authors.forename: Tianming
authors.initials: T
authors.lastname: Teng
authors.affiliation: Department of Cardiology, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin, 300052, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Bian
authors.affiliation: Department of Cardiology, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin, 300052, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Yao
authors.affiliation: Department of Cardiology, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin, 300052, China.
authors.forename: Xuefang
authors.initials: X
authors.lastname: Yu
authors.affiliation: Department of Cardiology, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin, 300052, China.
authors.forename: Zhuoqun
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Physiology & Pathophysiology, Tianjin Medical University, 22 Qixiangtai Road, Tianjin, 300070, China. tjykdxxuzhelong@outlook.com.
authors.forename: Zhelong
authors.initials: Z
authors.lastname: Xu
authors.affiliation: Department of Cardiology, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin, 300052, China. zyysunyuemin@outlook.com.
authors.forename: Yuemin
authors.initials: Y
authors.lastname: Sun
mesh_terms: D000368:Aged; D015992:Body Mass Index; D004452:Echocardiography; D005260:Female; D006706:Homeostasis; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012044:Regression Analysis; D012307:Risk Factors; D015032:Zinc / Q000097:blood*
chemical_list: D008055:Lipids; D015032:Zinc
keywords: Left ventricular hypertrophy (LVH); Left ventricular mass (LVM); Left ventricular mass index (LVMI); Zinc