title: High-Throughput Microfluidic Device for Circulating Tumor Cell Isolation from Whole Blood.
abstract: Circulating tumor cells (CTCs) are promising markers to determine cancer patient prognosis and track disease response to therapy. We present a multi-stage microfluidic device we have developed that utilizes inertial and Dean drag forces for isolating CTCs from whole blood. We demonstrate a 94.2% ± 2.1% recovery of cancer cells with our device when screening whole blood spiked with MCF-7 GFP cells.
authors.affiliation: Dept. of Mechanical Engineering, University of California, Berkeley, CA 94720 USA.
authors.forename: Daniel K
authors.initials: DK
authors.lastname: Yang
authors.affiliation: Dept. of Bioengineering, University of California, Berkeley, CA 94720 USA.
authors.forename: Serena
authors.initials: S
authors.lastname: Leong
authors.affiliation: Dept. of Mechanical Engineering, University of California, Berkeley, CA 94720 USA.
authors.forename: Lydia L
authors.initials: LL
authors.lastname: Sohn
keywords: CTC; Inertial microfluidics; Size-based separation