title: Insights on methotrexate in psoriatic disease.
abstract: The folic acid analogue methotrexate is used as an anti-neoplastic agent and treatment for inflammatory disorders including psoriasis, dermatomyositis, lupus erythematous, sarcoidosis, and systemic sclerosis. Despite the introduction of newer biologic agents, methotrexate remains a first-line systemic therapy for many patients with disorders of chronic inflammation. Here we briefly describe the current clinical evidence for methotrexate use in psoriatic disease, our current understanding of methotrexate's anti-inflammatory properties, and the future role of methotrexate in the treatment of immune mediated disorders.
authors.affiliation: Department of Dermatology, Tufts Medical Center, 800 Washington Street, Box 114, Boston, Massachusetts, 02111, USA; Tufts University School of Medicine, 136 Harrison Avenue, Boston, Massachusetts, 02111, USA. Electronic address: jegreb@gmail.com.
authors.forename: Jacqueline E
authors.initials: JE
authors.lastname: Greb
authors.affiliation: Department of Dermatology, Tufts Medical Center, 800 Washington Street, Box 114, Boston, Massachusetts, 02111, USA; Tufts University School of Medicine, 136 Harrison Avenue, Boston, Massachusetts, 02111, USA. Electronic address: ari.goldminz@gmail.com.
authors.forename: Ari M
authors.initials: AM
authors.lastname: Goldminz
authors.affiliation: Tufts University School of Medicine, 136 Harrison Avenue, Boston, Massachusetts, 02111, USA. Electronic address: alice.gottlieb@gmail.com.
authors.forename: Alice B
authors.initials: AB
authors.lastname: Gottlieb
mesh_terms: D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D018501:Antirheumatic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000517:prevention & control; D006801:Humans; D008727:Methotrexate / Q000494:pharmacology / Q000627:therapeutic use*; D011565:Psoriasis / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D018501:Antirheumatic Agents; D008727:Methotrexate
keywords: Adenosine; Cardiovascular disease; Methotrexate; Psoriasis; Psoriatic arthritis; T-cell