title: Touch cytology smear of an inflammatory hepatocellular adenoma displaying an unusual pattern: A case report.
abstract: The cytological diagnosis of hepatocellular adenoma (HCA) is difficult since it is a very rare tumor and lacks characteristic cytological features. We have just reported a case of inflammatory HCA that displayed an unusual histological pattern (Clin J Gastroenterol 8:426-434, 2015). A touch cytology smear sample was obtained from the surgical specimen, and it also exhibited very unique features. A 56-year-old male underwent partial hepatectomy for an inflammatory HCA (diameter: 1.4 cm) in the right posterior lobe of the liver. The cytological sample displayed a characteristic two-cell pattern. One type of cells contained thick cytoplasm, a high nucleus/cytoplasmic (N/C) ratio, and well-defined cytoplasmic borders. The other type demonstrated small pyknotic nuclei and a lower N/C ratio. The immunohistochemical staining pattern of the histological specimen suggested that the latter cells might have been undergoing apoptosis. We report a case of inflammatory HCA with characteristic features. To diagnose this type of variant, it is important to recognize the unique pattern described in this study. Diagn. Cytopathol. 2016;44:1074-1077. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Department of Pathology, the Cancer Institute of the Japanese Foundation for Cancer Research (JFCR), Tokyo, Japan.|Clinicopathology Center, the Cancer Institute Hospital of JFCR, Tokyo, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kanda
authors.affiliation: Department of Pathology, the Cancer Institute of the Japanese Foundation for Cancer Research (JFCR), Tokyo, Japan.|Department of Medical Laboratory Science, Clinical Cytology, Kitasato University, Kanagawa, Japan.
authors.forename: Reiko
authors.initials: R
authors.lastname: Furuta
authors.affiliation: Department of Pathology, the Cancer Institute of the Japanese Foundation for Cancer Research (JFCR), Tokyo, Japan.|Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Motoi
authors.affiliation: Clinicopathology Center, the Cancer Institute Hospital of JFCR, Tokyo, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Suzuki
authors.affiliation: Clinicopathology Center, the Cancer Institute Hospital of JFCR, Tokyo, Japan.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Furuta
authors.affiliation: Clinicopathology Center, the Cancer Institute Hospital of JFCR, Tokyo, Japan.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Komatsu
authors.affiliation: Clinicopathology Center, the Cancer Institute Hospital of JFCR, Tokyo, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Sugiyama
authors.affiliation: Department of Surgery, the Cancer Institute Hospital of JFCR, Tokyo, Japan.
authors.forename: Akio
authors.initials: A
authors.lastname: Saiura
authors.affiliation: Department of Pathology, School of Medicine, Nihon University, Tokyo, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Sugitani
authors.affiliation: Department of Pathology, the Cancer Institute of the Japanese Foundation for Cancer Research (JFCR), Tokyo, Japan.|Clinicopathology Center, the Cancer Institute Hospital of JFCR, Tokyo, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Ishikawa
mesh_terms: D018248:Adenoma, Liver Cell / Q000473:pathology*; D002467:Cell Nucleus / Q000473:pathology; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged
keywords: apoptosis; hepatocellular adenoma; touch cytology smear