title: [Patients with prostatic cancer undergoing radical prostatectomy after single positive core biopsy: a clinicopathologic analysis of 62 cases].
abstract: OBJECTIVE
  To evaluate the clinical and pathological features of patients with prostate cancer who had only one positive biopsy core and underwent radical prostatectomy (RP).
  
  
  METHODS
  A total of 62 patients with prostate cancer who had only one positive biopsy core and underwent RP were enrolled. The clinicopathological features of the biopsy and RP were analyzed. Those factors that may cause discordance of Gleason score (GS) and influence pathological T (pT) stage on RP were further evaluated.
  
  
  RESULTS
  Out of the 62 patients, 40(64.5%) had pT stage ≥pT2c. The positive surgical margins, extraprostatic extension and seminal vesicle invasion were found in 17.7%(11/62), 9.7%(6/62) and 3.2%(2/62) of patients, respectively. Compared to GS of RP, that of biopsy specimens was concordant in 39 (62.9%), higher in 6 (9.7%), and lower in 17 (27.4%) patients. There was no significant correlation between GS discordance and age, preoperative PSA level, FPSA/TPSA or maximum percentage of cancer per core (P>0.05). The maximum percentage of cancer per core (χ(2)=6.670 7, P=0.009 8) and biopsy GS (χ(2)=4.020 0, P=0.045 0) were significantly related to the pT stage on RP.
  
  
  CONCLUSIONS
  Single positive core prostate cancer at biopsy should not be considered as a low-risk disease. Although the preoperative clinicopathological factors cannot predict lower GS on biopsy, the maximum percentage of cancer per core and GS on biopsy are of significance to the pT stage on RP.
authors.affiliation: Department of Pathology, School of Basic Medical Science, Peking University Health Science Center; Department of Pathology, the Third Hospital of Peking University, Beijing 100191, China.
authors.forename: S J
authors.initials: SJ
authors.lastname: Du
authors.forename: H Y
authors.initials: HY
authors.lastname: He
mesh_terms: D001706:Biopsy; D062005:Biopsy, Large-Core Needle; D006801:Humans; D008297:Male; D000072662:Margins of Excision; D060787:Neoplasm Grading; D018365:Neoplasm, Residual; D011468:Prostatectomy / Q000379:methods*; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery*