title: Mycoplasma hyorhinis is a potential pathogen of porcine respiratory disease complex that aggravates pneumonia caused by porcine reproductive and respiratory syndrome virus.
abstract: The porcine respiratory disease complex (PRDC) caused by numerous bacterial and viral agents has a great impact on pig industry worldwide. Although Mycoplasma hyorhinis (Mhr) has been frequently isolated from lung lesions from pigs with PRDC, the pathological importance of Mhr may have been underestimated. In this study, 383 serum samples obtained from seven herds with a history of PRDC were tested for specific antibodies to Mhr, Mycoplasma hyopneumoniae (Mhp), and porcine reproductive and respiratory syndrome virus (PRRSV). Seropositive rates of PRRSV were significantly correlated with those of Mhr (correlation coefficient, 0.862; P-value, 0.013), but not with those of Mhp (correlation coefficient, -0.555; P-value, 0.196). In vivo experiments demonstrated that pigs co-infected with Mhr and PRRSV induced more severe lung lesions than pigs infected with Mhr or PRRSV alone. These findings suggest that Mhr is closely associated with pneumonia caused by PRRSV and provide important information on Mhr pathogenesis within PRDC. Therefore, effective PRDC control strategies should also consider the potential impact of Mhr in the pathogenesis of PRDC.
authors.affiliation: College of Veterinary Medicine, Konkuk University, Seoul 143-701, Republic of Korea; Division of Vaccine Research, National Institute of Health, Centers for Disease Control and Prevention, Osong-eup, CheongJu, Chungcheongbuk-do 363-951, Republic of Korea.
authors.forename: Jung-Ah
authors.initials: JA
authors.lastname: Lee
authors.affiliation: College of Veterinary Medicine, Konkuk University, Seoul 143-701, Republic of Korea.
authors.forename: Yu-Ri
authors.initials: YR
authors.lastname: Oh
authors.affiliation: College of Veterinary Medicine, Konkuk University, Seoul 143-701, Republic of Korea.
authors.forename: Min-A
authors.initials: MA
authors.lastname: Hwang
authors.affiliation: College of Veterinary Medicine, Konkuk University, Seoul 143-701, Republic of Korea.
authors.forename: Joong-Bok
authors.initials: JB
authors.lastname: Lee
authors.affiliation: College of Veterinary Medicine, Konkuk University, Seoul 143-701, Republic of Korea.
authors.forename: Seung-Yong
authors.initials: SY
authors.lastname: Park
authors.affiliation: College of Veterinary Medicine, Konkuk University, Seoul 143-701, Republic of Korea.
authors.forename: Chang-Seon
authors.initials: CS
authors.lastname: Song
authors.affiliation: College of Veterinary Medicine, Konkuk University, Seoul 143-701, Republic of Korea.
authors.forename: In-Soo
authors.initials: IS
authors.lastname: Choi
authors.affiliation: College of Veterinary Medicine, Konkuk University, Seoul 143-701, Republic of Korea. Electronic address: odssey@konkuk.ac.kr.
authors.forename: Sang-Won
authors.initials: SW
authors.lastname: Lee
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood; D060085:Coinfection / Q000209:etiology / Q000382:microbiology / Q000821:virology; D008168:Lung / Q000382:microbiology / Q000473:pathology / Q000821:virology; D045790:Mycoplasma hyorhinis / Q000276:immunology / Q000472:pathogenicity*; D045729:Pneumonia of Swine, Mycoplasmal / Q000209:etiology / Q000382:microbiology / Q000821:virology; D019318:Porcine Reproductive and Respiratory Syndrome / Q000209:etiology* / Q000382:microbiology* / Q000821:virology; D019316:Porcine respiratory and reproductive syndrome virus / Q000276:immunology / Q000472:pathogenicity*; D034421:Sus scrofa; D013552:Swine; D014774:Virulence
chemical_list: D000907:Antibodies, Bacterial; D000914:Antibodies, Viral
keywords: Mycoplasma hyopneumoniae; Mycoplasma hyorhinis; Porcine reproductive and respiratory syndrome virus; Porcine respiratory disease complex