title: COHb Level and High-Sensitivity Cardiac Troponin T in 2012 in Bursa, Turkey: A Retrospective Single-Center Study.
abstract: BACKGROUND
  Intoxication due to carbon monoxide (CO) is one of the most common types of poisoning. Cardiac effects of carboxyhemoglobin (COHb) range from simple arrhythmias to myocardial infarction.
  
  
  OBJECTIVE
  The current study aimed to investigate the relationship between blood carboxyhemoglobin and high-sensitivity cardiac troponin T (hs-cTnT) level with a highly sensitive assay in patients with acute carbon monoxide poisoning.
  
  
  METHODS
  This retrospective study was conducted on 141 (54 males and 87 females) patients, with acute CO intoxication, admitted to the Sevket Yilmaz research and education hospital emergency unit during a one-year period (January 2012 - January 2013). The patients were divided into three groups based on COHb levels: Group I, mild COHb level < 15%; Group II, COHb between 15% and 25%; Group III, severe acute CO intoxication COHb levels > 25%. COHb, hs-cTnT (Stat), creatine kinase (CK) and creatine kinase-myocardial band (CK-MB) levels were measured on admission.
  
  
  RESULTS
  The mean age of the patients was 38 ± 16 years. COHb levels ranged from 8 to 35. hs-cTnT levels on inclusion in this study were slightly different between the groups (P = 0.05). COHb levels with hs-cTnT values were weakly correlated (r = 0.173, P = 0.041); on the other hand, CK-MB levels were not correlated with COHb (r = 0.013, P = 0.883).
  
  
  CONCLUSIONS
  In patients without clear signs of myocardial infarction, even mild CO poisoning was associated with quantifiable circulating levels of hs-cTnT when TnT was measured using a highly sensitive assay in the current study patients. Plasma levels of the hs-TnT and CK-MB assays were not correlated with the COHb levels in the current study patients.
authors.affiliation: Sevket Yilmaz Education and Research Hospital, Clinical Laboratory Section, Bursa, Turkey.
authors.forename: Kagan
authors.initials: K
authors.lastname: Huysal
authors.affiliation: Sevket Yilmaz Education and Research Hospital, Clinical Laboratory Section, Bursa, Turkey.
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Ustundag Budak
authors.affiliation: Sevket Yilmaz Education and Research Hospital, Cardiovasculer Surgery Section, Bursa, Turkey.
authors.forename: Ufuk
authors.initials: U
authors.lastname: Aydin
authors.affiliation: Sevket Yilmaz Education and Research Hospital, Family Medicine Section, Bursa, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Demirci
authors.affiliation: Sevket Yilmaz Education and Research Hospital, Cardiovasculer Surgery Section, Bursa, Turkey.
authors.forename: Tamer
authors.initials: T
authors.lastname: Turk
authors.affiliation: Sevket Yilmaz Education and Research Hospital, Pulmonary Medicine Section, Bursa, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Karadag
keywords: Carbon Monoxide Poisoning; Cardiac; Troponin T