title: Association of Polymorphisms in STRA6 and RARRES2 Genes with Type 2 Diabetes in Southern Han Chinese.
abstract: Stimulated by retinoic acid gene homolog 6 (STRA6) and retinoic acid receptor responder 2 (RARRES2) are candidate genes involved in the pathogenesis of type 2 diabetes mellitus (T2DM). Three tag-SNPs in STRA6 and one in RARRES2 gene were selected and genotyped with TaqMan or PCR-RFLP method in 603 populations (571 patients with T2D versus 632 control subjects) in Southern Han Chinese. We estimated the interactions between T2DM risk and genetic variants in the STRA6 and RARRES2 genes using polymerase chain reaction. Rs736118 in STRA6 gene were significantly associated with T2DM occurrence in the recessive genetic model. The genotype of rs974456 was significantly associated with T2DM in the dominant genetic model correlated to sex, MBI, and triglyceride. However, the association of other SNPs with T2DM was not found. Furthermore, smoking history and other factors may be independent risk factors for the incidence of T2DM. This study suggested that a role of STRA6 polymorphism could also be of value in predicting the risk of T2DM while RARRES2 polymorphism could not predict the risk of T2DM.
authors.affiliation: Department of Endocrinology, The Affiliated Zhongshan Hospital of Guangdong Medical College, Zhuyuan Road 18, Xiaolan, Zhongshan 528415, China.
authors.forename: Han-Wei
authors.identifier: 0000-0002-6067-1725
authors.initials: HW
authors.lastname: Huang
authors.affiliation: Department of Endocrinology, The Affiliated Zhongshan Hospital of Guangdong Medical College, Zhuyuan Road 18, Xiaolan, Zhongshan 528415, China.
authors.forename: Bi-Yu
authors.initials: BY
authors.lastname: Liang
authors.affiliation: Department of Clinical Laboratory, The Affiliated Zhongshan Hospital of Guangdong Medical College, Zhuyuan Road 18, Xiaolan, Zhongshan 528415, China.
authors.forename: Yun-Xi
authors.initials: YX
authors.lastname: Li
mesh_terms: D000368:Aged; D018925:Chemokines / Q000235:genetics*; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000473:pathology; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D018925:Chemokines; D036341:Intercellular Signaling Peptides and Proteins; D008565:Membrane Proteins; C478630:RARRES2 protein, human; C519685:STRA6 protein, human