title: Transcriptional regulation by complex interplay between post-translational modifications.
abstract: Transcriptional reprogramming in response to developmental changes or environmental inputs is regulated by a wide variety of transcription factors and cofactors. In plants, the stability of many transcriptional regulators is mediated by the ubiquitin-mediated proteasome. Recent reports suggest that additional post-translational modifications modulate the ubiquitination and thus stability of transcriptional regulators. In addition to well-recognized phosphorylative control, particularly conjugation to the ubiquitin-like protein SUMO as well as thiol modification by nitric oxide to yield S-nitrosothiols, are emerging as key regulatory steps for governing protein ubiquitination in the nucleus. Complex interplay between these different post-translational modifications may provide robust control mechanisms to fine tune developmental and stress-responsive transcriptional programs.
authors.affiliation: Institute of Molecular Plant Sciences, School of Biological Sciences, University of Edinburgh, King's Buildings, Max Born Crescent, Edinburgh EH9 3BF, United Kingdom.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Skelly
authors.affiliation: Institute of Molecular Plant Sciences, School of Biological Sciences, University of Edinburgh, King's Buildings, Max Born Crescent, Edinburgh EH9 3BF, United Kingdom.
authors.forename: Lucas
authors.initials: L
authors.lastname: Frungillo
authors.affiliation: Institute of Molecular Plant Sciences, School of Biological Sciences, University of Edinburgh, King's Buildings, Max Born Crescent, Edinburgh EH9 3BF, United Kingdom. Electronic address: steven.spoel@ed.ac.uk.
authors.forename: Steven H
authors.initials: SH
authors.lastname: Spoel
mesh_terms: D018506:Gene Expression Regulation, Plant; D010940:Plant Proteins / Q000235:genetics* / Q000378:metabolism; D010944:Plants / Q000235:genetics* / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism; D054875:Ubiquitination
chemical_list: D010940:Plant Proteins; D014157:Transcription Factors