title: Effect of Monotherapy with Darunavir/Ritonavir on Viral Load in Seminal Fluid, and Quality Parameters of Semen in HIV-1-Positive Patients.
abstract: Patients with human immunodeficiency virus type 1 (HIV-1) who receive antiretroviral therapy (ART) often achieve increased survival and improved quality of life. In this respect, monotherapy with darunavir/ritonavir (mDRV/r) can be a useful treatment strategy. This prospective study analyses the effect of mDRV/r on sperm quality and viral load in a group of 28 patients who had previously been given conventional ART and who had recorded a viral load <20 copies/mL for at least six months. These patients were given mDRV/r at a dose of 800/100 mg for 48 weeks. At baseline (V0), CD4, CD8, FSH, LH and testosterone levels were measured, together with HIV-1 viral load in plasma and semen. In addition, seminal fluid quality was studied before mDRV/r treatment was prescribed. At week 48 (V1), HIV-1 viral load in plasma and semen and the quality of the seminal fluid were again measured. The results obtained indicate that at V0, 10% of the patients with ART had a positive viral load in seminal fluid (>20 copies/ml), and that at V1, after mDRV/r treatment, this figure had fallen to 3%. The quality of seminal fluid was close to normal in 57% of patients at V0 and in 62% at V1. We conclude that, similar to ART, mDRV/r maintains HIV-1 viral load in most patients, and that there is no worsening in seminal fluid quality.
authors.affiliation: Unidad de Enfermedades Infecciosas, Hospital Virgen de las Nieves, Complejo Hospitalario Universitario Granada, Instituto de Investigación Biosanitaria de Granada (IIBG), Granada, Spain.
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Lopez-Ruz
authors.affiliation: Unidad Reproducción, UGC Laboratorio Clínico y UGC Obstetricia y Ginecología, Complejo Hospitalario Universitario Granada, Instituto de Investigación Biosanitaria de Granada (IIBG), Granada, Spain.|Dpto. Anatomía y Embriología Humana, Programa del Doctorado de Biomedicina Regenerativa, Universidad de Granada, Granada, Spain.
authors.forename: Purificación
authors.initials: P
authors.lastname: Navas
authors.affiliation: Unidad de Enfermedades Infecciosas, Hospital Virgen de las Nieves, Complejo Hospitalario Universitario Granada, Instituto de Investigación Biosanitaria de Granada (IIBG), Granada, Spain.
authors.forename: Miguel A
authors.initials: MA
authors.lastname: López-Zúñiga
authors.affiliation: Unidad Reproducción, UGC Laboratorio Clínico y UGC Obstetricia y Ginecología, Complejo Hospitalario Universitario Granada, Instituto de Investigación Biosanitaria de Granada (IIBG), Granada, Spain.
authors.forename: María Carmen
authors.initials: MC
authors.lastname: Gonzalvo
authors.affiliation: Unidad de Microbiología, Hospital Virgen de las Nieves, Complejo Hospitalario Universitario Granada, Instituto de Investigación Biosanitaria de Granada (IIBG), Granada, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Sampedro
authors.affiliation: Unidad de Enfermedades Infecciosas, Hospital Virgen de las Nieves, Complejo Hospitalario Universitario Granada, Instituto de Investigación Biosanitaria de Granada (IIBG), Granada, Spain.
authors.forename: Juan
authors.initials: J
authors.lastname: Pasquau
authors.affiliation: Unidad de Enfermedades Infecciosas, Hospital Virgen de las Nieves, Complejo Hospitalario Universitario Granada, Instituto de Investigación Biosanitaria de Granada (IIBG), Granada, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Hidalgo-Tenorio
authors.affiliation: Unidad de Enfermedades Infecciosas, Hospital Virgen de las Nieves, Complejo Hospitalario Universitario Granada, Instituto de Investigación Biosanitaria de Granada (IIBG), Granada, Spain.
authors.forename: Rosario
authors.initials: R
authors.lastname: Javier
authors.affiliation: Unidad Reproducción, UGC Laboratorio Clínico y UGC Obstetricia y Ginecología, Complejo Hospitalario Universitario Granada, Instituto de Investigación Biosanitaria de Granada (IIBG), Granada, Spain.|Dpto. Anatomía y Embriología Humana, Programa del Doctorado de Biomedicina Regenerativa, Universidad de Granada, Granada, Spain.
authors.forename: José A
authors.initials: JA
authors.lastname: Castilla
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D000069454:Darunavir / Q000494:pharmacology / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology*; D006801:Humans; D008297:Male; D019438:Ritonavir / Q000494:pharmacology / Q000627:therapeutic use*; D012661:Semen / Q000187:drug effects / Q000821:virology*; D019562:Viral Load / Q000187:drug effects
chemical_list: D019438:Ritonavir; D000069454:Darunavir