title: Carotid intima-media thickness and cognitive function in a middle-aged and older adult community: a cross-sectional study.
abstract: The relationship between atherosclerosis and cognitive function is less well studied in Chinese populations. In addition, the results among middle-aged adults have been mixed. We aimed to investigate the association of atherosclerosis measured by carotid intima-media thickness (CIMT) and cognitive function in middle-aged and older adults from a Chinese community. Participants in the Asymptomatic Polyvascular Abnormalities in Community study (APAC) who had completed the CIMT detection and cognitive function measurements in 2012/2013 were included. Cognitive function was measured using the Mini-Mental State Examination (MMSE). Multivariate linear regression analysis was used to analyze the association between CIMT and MMSE. Then, a stratified analysis was performed separately in middle-aged and older adults. A total of 3227 participants were included in this study (mean age 57.9 years, range 43-93 years); 56.6 % of them were men, 66.0 % were middle-aged adults. After adjusting for potential confounders, larger CIMT was associated with lower MMSE scores, with a 0.75-point decrease in MMSE score for every 1-mm increase in CIMT (β = - 0.75, P = 0.0020). The association remained statistically significant in middle-aged adults (β = - 0.57, P = 0.0390), and was stronger in older adults and adults with low education levels. There is a significant association between CIMT and cognitive function among middle-aged and older adults sampled from a Chinese population. This association was stronger in older adults and adults with low education levels.
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, 100050, Beijing, China.|China National Clinical Research Center for Neurological Diseases, Beijing, China.|Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China.|Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China.|Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, 100069, Beijing, China.
authors.forename: Anxin
authors.initials: A
authors.lastname: Wang
authors.affiliation: Department of Neurology, Tangshan Gongren Hospital, North China University of Science and Technology, Tangshan, China.
authors.forename: Guojuan
authors.initials: G
authors.lastname: Chen
authors.affiliation: Department of Epidemiology and Health Statistics, Academy of Public Health and Management, Weifang Medical University, Weifang, China.
authors.forename: Zhaoping
authors.initials: Z
authors.lastname: Su
authors.affiliation: Department of Cardiology, Tangshan People's Hospital, North China University of Science and Technology, Tangshan, China.
authors.forename: Xiaoxue
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Neurology, Kailuan Hospital, North China University of Science and Technology, Tangshan, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Yuan
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, 100050, Beijing, China.|China National Clinical Research Center for Neurological Diseases, Beijing, China.|Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China.|Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China.
authors.forename: Ruixuan
authors.initials: R
authors.lastname: Jiang
authors.affiliation: Department of Neurology, Tangshan Gongren Hospital, North China University of Science and Technology, Tangshan, China.
authors.forename: Yibin
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Department of Cardiology, Kailuan Hospital, North China University of Science and Technology, 063000, Tangshan, China.
authors.forename: Shuohua
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, 100069, Beijing, China.
authors.forename: Yanxia
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, 100069, Beijing, China. statguo@ccmu.edu.cn.
authors.forename: Xiuhua
authors.initials: X
authors.lastname: Guo
authors.affiliation: Department of Cardiology, Kailuan Hospital, North China University of Science and Technology, 063000, Tangshan, China. drwusl@163.com.
authors.forename: Shouling
authors.initials: S
authors.lastname: Wu
authors.affiliation: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, 100050, Beijing, China. zxq@vip.163.com.|China National Clinical Research Center for Neurological Diseases, Beijing, China. zxq@vip.163.com.|Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China. zxq@vip.163.com.|Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China. zxq@vip.163.com.
authors.forename: Xingquan
authors.initials: X
authors.lastname: Zhao
mesh_terms: D000367:Age Factors; D000368:Aged; D000375:Aging; D050197:Atherosclerosis / Q000150:complications*; D059168:Carotid Intima-Media Thickness; D002681:China; D003072:Cognition Disorders / Q000000981:diagnostic imaging* / Q000209:etiology*; D003430:Cross-Sectional Studies; D004522:Educational Status; D005260:Female; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D009483:Neuropsychological Tests; D012111:Residence Characteristics; D018709:Statistics, Nonparametric
keywords: Atherosclerosis; Carotid intima-media thickness; Cognitive impairment; MMSE