title: Growth hormone receptor gene variant and three-dimensional mandibular morphology.
abstract: OBJECTIVE
  To examine the relationship between three-dimensional mandibular morphology and growth hormone receptor (GHR) gene variants in a healthy Japanese population.
  
  
  METHODS
  The subjects, who were unrelated Japanese orthodontic patients, consisted of 64 men and 114 women. Using the Taqman genotyping assay, GHR gene rs6184 and rs6180 variants were detected in genomic DNA extracted from saliva. Mandibular volume and length were measured from cone-beam computed tomography images that were analyzed using Analyze image-processing software. The relationship between GHR gene variants and three-dimensional mandibular morphology was statistically examined.
  
  
  RESULTS
  Statistical significance for the relationship between the distance between the left and right coronoid processes and rs6180 was noted (P < .05).
  
  
  CONCLUSIONS
  Our results indicate that the GHR variant rs6180 is associated with the distance between the left and right coronoid process in the Japanese subjects.
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Nakawaki
authors.forename: Tetsutaro
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Mutsumi
authors.initials: M
authors.lastname: Isa
authors.forename: Akira
authors.initials: A
authors.lastname: Kawaguchi
authors.forename: Daisuke
authors.initials: D
authors.lastname: Tomita
authors.forename: Yu
authors.initials: Y
authors.lastname: Hikita
authors.forename: Yoko
authors.initials: Y
authors.lastname: Suzuki-Tomoyasu
authors.forename: Mohamed
authors.initials: M
authors.lastname: Adel
authors.forename: Hajime
authors.initials: H
authors.lastname: Ishida
authors.forename: Koutaro
authors.initials: K
authors.lastname: Maki
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Kimura
mesh_terms: D000293:Adolescent; D000328:Adult; D054893:Cone-Beam Computed Tomography / Q000379:methods; D005260:Female; D014644:Genetic Variation; D015894:Genome, Human / Q000235:genetics; D005838:Genotype; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods*; D007564:Japan; D008297:Male; D008334:Mandible / Q000033:anatomy & histology* / Q000000981:diagnostic imaging*; D008335:Mandibular Condyle / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000254:growth & development; D008437:Maxilla / Q000033:anatomy & histology / Q000000981:diagnostic imaging; D008875:Middle Aged; D011986:Receptors, Somatotropin / Q000235:genetics*; D012044:Regression Analysis; D012463:Saliva; D055815:Young Adult
chemical_list: D011986:Receptors, Somatotropin
keywords: GHR; Three-dimensional mandibular morphology