title: The evidence-practice gap in specialist mental healthcare: systematic review and meta-analysis of guideline implementation studies.
abstract: Clinical practice guidelines are not easily implemented, leading to a gap between research synthesis and their use in routine care.
  
  
  
  To summarise the evidence relating to the impact of guideline implementation on provider performance and patient outcomes in mental healthcare settings, and to explore the performance of different strategies for guideline implementation.
  
  
  
  A systematic review of randomised controlled trials, controlled clinical trials and before-and-after studies comparing guideline implementation strategies v. usual care, and different guideline implementation strategies, in patients with severe mental illness.
  
  
  
  In total, 19 studies met our inclusion criteria. The studies did not show a consistent positive effect of guideline implementation on provider performance, but a more consistent small to modest positive effect on patient outcomes.
  
  
  
  Guideline implementation does not seem to have an impact on provider performance, nonetheless it may influence patient outcomes positively.
authors.affiliation: Francesca Girlanda, PhD, Department of Psychiatry ll, Ulm University, Ulm, Germany, and Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy; Ines Fiedler, MSc, Thomas Becker, MD, Department of Psychiatry ll, Ulm University, Ulm, Germany; Corrado Barbui, MD, Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy; Markus Koesters, PhD, Department of Psychiatry ll, Ulm University, Ulm, Germany francesca.girlanda@uni-ulm.de.
authors.forename: Francesca
authors.initials: F
authors.lastname: Girlanda
authors.affiliation: Francesca Girlanda, PhD, Department of Psychiatry ll, Ulm University, Ulm, Germany, and Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy; Ines Fiedler, MSc, Thomas Becker, MD, Department of Psychiatry ll, Ulm University, Ulm, Germany; Corrado Barbui, MD, Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy; Markus Koesters, PhD, Department of Psychiatry ll, Ulm University, Ulm, Germany.
authors.forename: Ines
authors.initials: I
authors.lastname: Fiedler
authors.affiliation: Francesca Girlanda, PhD, Department of Psychiatry ll, Ulm University, Ulm, Germany, and Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy; Ines Fiedler, MSc, Thomas Becker, MD, Department of Psychiatry ll, Ulm University, Ulm, Germany; Corrado Barbui, MD, Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy; Markus Koesters, PhD, Department of Psychiatry ll, Ulm University, Ulm, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Becker
authors.affiliation: Francesca Girlanda, PhD, Department of Psychiatry ll, Ulm University, Ulm, Germany, and Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy; Ines Fiedler, MSc, Thomas Becker, MD, Department of Psychiatry ll, Ulm University, Ulm, Germany; Corrado Barbui, MD, Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy; Markus Koesters, PhD, Department of Psychiatry ll, Ulm University, Ulm, Germany.
authors.forename: Corrado
authors.initials: C
authors.lastname: Barbui
authors.affiliation: Francesca Girlanda, PhD, Department of Psychiatry ll, Ulm University, Ulm, Germany, and Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy; Ines Fiedler, MSc, Thomas Becker, MD, Department of Psychiatry ll, Ulm University, Ulm, Germany; Corrado Barbui, MD, Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy; Markus Koesters, PhD, Department of Psychiatry ll, Ulm University, Ulm, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Koesters
mesh_terms: D019983:Guideline Adherence; D006801:Humans; D001523:Mental Disorders / Q000628:therapy*; D008605:Mental Health Services / Q000592:standards*; D010043:Outcome and Process Assessment, Health Care; D000071836:Professional Practice Gaps