title: Mid-term and long-term follow-up of intracranial aneurysms treated by the p64 Flow Modulation Device: a multicenter experience.
abstract: BACKGROUND
  Experience with the endovascular treatment of cerebral aneurysms using the p64 Flow Modulation Device is still limited. This study discusses the results and complications of this new flow diverter device.
  
  
  METHODS
  40 patients (30 women, 10 men) with 50 cerebral aneurysms treated in six Italian neurointerventional centers with the p64 Flow Modulation Device between April 2013 and September 2015 were retrospectively reviewed.
  
  
  RESULTS
  Complete occlusion was obtained in 44/50 aneurysms (88%) and partial occlusion in 3 (6%). In the other three aneurysms (6%), two cases of asymptomatic in-stent thrombosis and one intraprocedural occlusion of the parent vessel occurred. Technical complications were observed in eight procedures (16%). Permanent morbidity due to acute in-stent thrombosis and consequent ischemic stroke occurred in one patient (2.5%). No delayed aneurysm rupture, subarachnoid or intraparenchymal hemorrhage, or ischemic complications occurred and there were no deaths.
  
  
  CONCLUSIONS
  Endovascular treatment with the p64 Flow Modulation Device is a safe treatment for unruptured cerebral aneurysms, resulting in a high rate of occlusion. As with other flow diverter devices, we recommend this treatment mainly for large-necked aneurysms of the internal carotid artery siphon. However, endovascular treatment with the p64 device should also be encouraged in difficult cases such as aneurysms of the posterior circulation and beyond the circle of Willis.
authors.affiliation: Unit of Interventional Neuroradiology, Department of Advanced Biomedical Sciences, 'Federico II' University, Naples, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Briganti
authors.affiliation: Department of Advanced Biomedical Sciences, 'Federico II' University, Naples, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Leone
authors.affiliation: Department of Advanced Biomedical Sciences, 'Federico II' University, Naples, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Ugga
authors.affiliation: Department of Advanced Biomedical Sciences, 'Federico II' University, Naples, Italy.|Department of Neuroradiology, 'Umberto I' Hospital, Nocera Inferiore, Salerno, Italy.
authors.forename: Mariano
authors.initials: M
authors.lastname: Marseglia
authors.affiliation: Department of Advanced Biomedical Sciences, 'Federico II' University, Naples, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Macera
authors.affiliation: Department of Neuroradiology, 'Umberto I' Hospital, Nocera Inferiore, Salerno, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Manto
authors.affiliation: Unit of Interventional Neuroradiology, San Giovanni Bosco Hospital, Naples, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Delehaye
authors.affiliation: Department of Radiology and Neuroradiology, 'SS Annunziata' Hospital, Taranto, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Resta
authors.affiliation: Unit of Neuroradiology, Aldo Moro University, Bari, Italy.
authors.forename: Mariachiara
authors.initials: M
authors.lastname: Resta
authors.affiliation: Department of Radiology and Neuroradiology, 'SS Annunziata' Hospital, Taranto, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Burdi
authors.affiliation: Unit of Neuroradiology, Humanitas Research Hospital, Rozzano, Milan, Italy.
authors.forename: Nunzio Paolo
authors.initials: NP
authors.lastname: Nuzzi
authors.affiliation: Department of Radiology, Azienda Ospedaliero-Universitaria Maggiore della Carità, Novara, Italy.
authors.forename: Ignazio
authors.initials: I
authors.lastname: Divenuto
authors.affiliation: Department of Advanced Biomedical Sciences, 'Federico II' University, Naples, Italy.
authors.forename: Ferdinando
authors.initials: F
authors.lastname: Caranci
authors.affiliation: Neuroradiology Department, Cardarelli Hospital, Naples, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Muto
authors.affiliation: Division of Neurosurgery, Department of Neurosciences, Reproductive and Odontostomatological Sciences, 'Federico II' University, Naples, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Solari
authors.affiliation: Division of Neurosurgery, Department of Neurosciences, Reproductive and Odontostomatological Sciences, 'Federico II' University, Naples, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Cappabianca
authors.affiliation: Division of Neurosurgery, Department of Neurosciences, Reproductive and Odontostomatological Sciences, 'Federico II' University, Naples, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Maiuri
mesh_terms: D000328:Adult; D000368:Aged; D002343:Carotid Artery, Internal / Q000000981:diagnostic imaging; D002533:Cerebral Angiography / Q000379:methods; D004621:Embolization, Therapeutic / Q000295:instrumentation / Q000379:methods; D057510:Endovascular Procedures / Q000295:instrumentation* / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015607:Stents; D020521:Stroke / Q000000981:diagnostic imaging / Q000628:therapy; D013997:Time Factors; D016896:Treatment Outcome
keywords: Aneurysm; Angiography; Flow Diverter