title: Coenzyme Q10 - A new player in the treatment of heart failure?
abstract: Coenzyme Q10 is the only endogenously synthesized lipid with a redox function which exhibits broad tissue and intracellular distribution in mammals. Beneficial effects of Coenzyme Q10 supplementation were observed in several age-related diseases including heart failure. CoQ10 (coenzyme Q10) level is significantly decreased in patients with this disease, which correlates with severity of clinical symptoms. Supplementation with various pharmaceutical formulations of CoQ10 improves impaired cardiac function and clinical course of heart failure. Current data from clinical trials indicate that CoQ10 can significantly reduce morbidity and mortality of heart failure patients in addition to guideline recommended pharmacotherapy.
authors.affiliation: Department of Clinical Pharmacology, Poznan University of Medical Sciences, Poznań, Poland.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Jankowski
authors.affiliation: Department of Clinical Pharmacology, Poznan University of Medical Sciences, Poznań, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Korzeniowska
authors.affiliation: Department of Clinical Pharmacology, Poznan University of Medical Sciences, Poznań, Poland. Electronic address: artcies@ump.edu.pl.
authors.forename: Artur
authors.initials: A
authors.lastname: Cieślewicz
authors.affiliation: Department of Clinical Pharmacology, Poznan University of Medical Sciences, Poznań, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Jabłecka
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D019587:Dietary Supplements; D006333:Heart Failure / Q000188:drug therapy* / Q000517:prevention & control*; D006801:Humans; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D014451:Ubiquinone; C024989:coenzyme Q10
keywords: Coenzyme Q10; Heart failure; Supplementation