title: Comparative Evaluation of Antimicrobial Activity of QMiX, 2.5% Sodium Hypochlorite, 2% Chlorhexidine, Guava Leaf Extract and Aloevera Extract Against Enterococcus faecalis and Candida albicans - An in-vitro Study.
abstract: BACKGROUND
  Debridement and disinfection of the root canal system is a critical step in endodontic treatment. Most of the irrigants presently used in the endodontic treatment can have an impact on the microbes surviving in the biofilm but none of them are able to do all of the required tasks. Researches are going on its full swing in order to produce an endodontic irrigant having ideal properties.
  
  
  OBJECTIVE
  To compare the antimicrobial efficacy of different irrigants like QMiX, guava leaf extract, aloevera extract, 2.5% sodium hypochlorite and 2% chlorhexidine gluconate against Enterococcus faecalis and Candida albicans.
  
  
  METHODS
  The antimicrobial activity was determined using agar diffusion test. The solutions were divided into five groups: Group I- QMiX, Group II- Guava leaf extract and Group III-Aloevera extract, Group IV-2.5% Sodium hypochlorite and Group V-2% Chlorhexidine. The zones of inhibition of growth were recorded.
  
  
  RESULTS
  Statistical analysis was performed using one way ANOVA with post-hoc Tukey's HSD. Values obtained were statistically analyzed (p<0.05). QMiX showed maximum inhibitory effect against Enterococcus faecalis and Candida albicans followed by, 2% chlorhexidine, 2.5% sodium hypochlorite, guava leaf extract and aloevera extract. Results obtained were statistically significant.
  
  
  CONCLUSIONS
  Guava leaf extract showed significant inhibitory effects against Enterococcus faecalis and Candida albicans. QMiX demonstrated the best results among the tested solutions and can be considered as a potential alternative to existing root canal irrigants.
authors.affiliation: Junior Resident, Department of Conservative Dentistry and Endodontics, Government Dental College , Kottayam, Kerala, India .
authors.forename: Jerin
authors.initials: J
authors.lastname: Jose
authors.affiliation: Professor and Head of Department, Department of Conservative Dentistry and Endodontics, Government Dental College , Kottayam, Kerala, India .
authors.forename: Shoba
authors.initials: S
authors.lastname: Krishnamma
authors.affiliation: Professor, Department of Pedodontics and Preventive Dentistry, Kannur Dental College , Kannur, India .
authors.forename: Faizal
authors.initials: F
authors.lastname: Peedikayil
authors.affiliation: Assistant Professor, Department of Conservative Dentistry and Endodontics, Government Dental College , Kottayam, Kerala, India .
authors.forename: Shibu
authors.initials: S
authors.lastname: Aman
authors.affiliation: Junior Resident, Department of Pedodontics and Preventive Dentistry, Kannur Dental College , Kannur, India .
authors.forename: Nithya
authors.initials: N
authors.lastname: Tomy
authors.affiliation: Junior Resident, Department of Pedodontics and Preventive Dentistry, Koorg Institute of Dental Sciences , Virajpettu, India .
authors.forename: Jithin Pulickal
authors.initials: JP
authors.lastname: Mariodan
keywords: Antimicrobial efficacy; Microbial infection; Root canal irrigation