title: The role of ppGalNAc-T family in breast cancer development and progression.
abstract: Glycosylation of proteins is an essential process in all eukaryotes. Mucin-type O-linked glycosylation is an evolutionarily conserved protein modification as a kind of glycosylation of proteins. The role of O-glycosylation was well documented in multiple cancers. While in breast cancer, the enzymes that catalyzed the initiation of O-glycosylation remained elusive. In this review, we briefly introduced the process of the initiation of O-glycosylation and summarized the roles of enzymes that catalyzed the initiation step of O-glycosylation in the breast cancer carcinogenesis, development, and progression. Finally, we summarized some attempts exploring the therapy against aberrant O-glycosylation.
authors.affiliation: Department of Respiratory Medicine, Yidu Central Hospital of Weifang, Qingzhou, China.
authors.forename: R
authors.initials: R
authors.lastname: Yang
authors.affiliation: Department of Respiratory Medicine, Yidu Central Hospital of Weifang, Qingzhou, China.
authors.forename: H
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Respiratory Medicine, Yidu Central Hospital of Weifang, Qingzhou, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Department of Respiratory Medicine, Yidu Central Hospital of Weifang, Qingzhou, China.
authors.forename: S
authors.initials: S
authors.lastname: Gong
authors.affiliation: Department of Respiratory Medicine, Yidu Central Hospital of Weifang, Qingzhou, China.
authors.forename: J
authors.initials: J
authors.lastname: Niu
authors.affiliation: Department of Respiratory Medicine, Yidu Central Hospital of Weifang, Qingzhou, China.
authors.forename: J
authors.initials: J
authors.lastname: Ma
authors.affiliation: Department of Respiratory Medicine, Yidu Central Hospital of Weifang, Qingzhou, China.
authors.forename: A
authors.initials: A
authors.lastname: Zhong
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006031:Glycosylation; D006801:Humans; D017350:N-Acetylgalactosaminyltransferases / Q000378:metabolism*; D000097763:Polypeptide N-acetylgalactosaminyltransferase
chemical_list: D017350:N-Acetylgalactosaminyltransferases; D000097763:Polypeptide N-acetylgalactosaminyltransferase