title: Acute flaccid weakness with myelopathy and peripheral nerve involvement in 2 children: Recent characterization of a previously observed phenomenon.
abstract: BACKGROUND
  Acute flaccid weakness may be the first presentation of acute transverse myelitis (ATM), an immune-mediated central nervous system disorder or may be the first presentation of anterior horn cell syndrome or peripheral nervous system disease.
  
  
  METHODS
  We describe two previously healthy female infants who presented with acute flaccid paralysis and encephalopathy. Neuroimaging revealed central cord signal changes in both cases and surprisingly electrophysiological studies performed revealed a generalized axonal motor neuropathy as well.
  
  
  CONCLUSIONS
  Clinical, radiological and neurophysiological assessment are important to aid in the diagnosis and subsequent management of children with overlapping inflammatory peripheral and central nervous system syndromes.
authors.affiliation: Children's Neurosciences, Evelina London Children's Hospital, Kings Health Partners Academic Health Science Centre, UK.
authors.forename: Gemma
authors.initials: G
authors.lastname: Olive
authors.affiliation: Paediatric Neurology Department, St Georges Healthcare NHS Trust, UK.
authors.forename: Antonia
authors.initials: A
authors.lastname: Clarke
authors.affiliation: Paediatric Infectious Diseases Unit, St Georges Healthcare NHS Trust, UK.
authors.forename: Katja
authors.initials: K
authors.lastname: Doerholt
authors.affiliation: Children's Neurosciences, Evelina London Children's Hospital, Kings Health Partners Academic Health Science Centre, UK.
authors.forename: Vasantha
authors.initials: V
authors.lastname: Gowda
authors.affiliation: Department of Neuroradiology, Guy's and St Thomas' NHS Foundation Trust, King's Health Partners Academic Health Science Centre, UK.
authors.forename: Atta
authors.initials: A
authors.lastname: Siddiqui
authors.affiliation: Children's Neurosciences, Evelina London Children's Hospital, Kings Health Partners Academic Health Science Centre, UK. Electronic address: Ming.Lim@gstt.nhs.uk.
authors.forename: Ming J
authors.initials: MJ
authors.lastname: Lim
mesh_terms: D001927:Brain Diseases; D002675:Child, Preschool; D003937:Diagnosis, Differential; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007223:Infant; D016472:Motor Neuron Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology; D009123:Muscle Hypotonia / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*; D018908:Muscle Weakness / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D009188:Myelitis, Transverse / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology; D059906:Neuroimaging; D010523:Peripheral Nervous System Diseases / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D013116:Spinal Cord / Q000000981:diagnostic imaging; D013118:Spinal Cord Diseases / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*
keywords: Acute flaccid weakness; Infectious etiology; Myelopathy; Peripheral nerve disease