title: ASSESSMENT OF WARFARIN TREATMENT EFFICACY BY MEANS; OF USING COAGULATION TEST RESULTS WITHIN THE THERAPEUTIC RANGE.
abstract: Time in Therapeutic Range (TTR) is a value used to assess the efficacy of Warfarin treatment. The aim of our study is to determine the effective INR levels and the rate of TTR in patients on Warfarin regimen due to Atrial Fibrillation (AF) or Mechanical Prosthetic Valve (MPV). A total of 94 patients (58 female, and 36 male, mean age: 64.9±11years) on Warfarin treatment due to AF or MPV with at least 10 INR levels measurements in the last 6 months were included in this retrospective study. The patients were divided into 2 groups. Group 1 consisted of the patients with Valvular AF (n=47); Group 2 included the patients with Non-Valvular AF (n=47); TTR and INR levels were compared. The average of INR values were found as 2,4 (min: 1,3, max: 4,3) in all patients; 2,3 (min: 1,3, max: 4,2) in Group 1; 2,6 (min: 1,3, max: 4,3) in Group 2. The average of TTR values was found 40.3% (min: 10%, max: 80%) in all patients; 43.8% (min: 10%, max: 80%) in Group 1; 36,8% (min: 10%, max: 80%) in Group 2. INR and TTR values are needed to assess the effectiveness of the Warfarin treatment. The patients in treatment with Warfarin should be well trained and frequently monitored. On the other hand, the underlying factors of the TTR values being determined as lower in the Turkish patient population might be due to the lower socio-economic and socio-cultural status, inadequate education levels, and the insufficient information on use of the medication provided by the doctors to the patients.
authors.affiliation: Department of Cardiology, Sakarya University, Medicine Faculty, Sakarya; Department of Internal Medicine, Sakarya University, Medicine Faculty, Sakarya; Department of Hematology, Sakarya University, Medicine Faculty, Sakarya; Department of Internal Medicine, Rize Findikli State Hospital, Rize, Turkey.
authors.forename: P
authors.initials: P
authors.lastname: Varim
authors.affiliation: Department of Cardiology, Sakarya University, Medicine Faculty, Sakarya; Department of Internal Medicine, Sakarya University, Medicine Faculty, Sakarya; Department of Hematology, Sakarya University, Medicine Faculty, Sakarya; Department of Internal Medicine, Rize Findikli State Hospital, Rize, Turkey.
authors.forename: C
authors.initials: C
authors.lastname: Varim
authors.affiliation: Department of Cardiology, Sakarya University, Medicine Faculty, Sakarya; Department of Internal Medicine, Sakarya University, Medicine Faculty, Sakarya; Department of Hematology, Sakarya University, Medicine Faculty, Sakarya; Department of Internal Medicine, Rize Findikli State Hospital, Rize, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Ergenç
authors.affiliation: Department of Cardiology, Sakarya University, Medicine Faculty, Sakarya; Department of Internal Medicine, Sakarya University, Medicine Faculty, Sakarya; Department of Hematology, Sakarya University, Medicine Faculty, Sakarya; Department of Internal Medicine, Rize Findikli State Hospital, Rize, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Uyanık
authors.affiliation: Department of Cardiology, Sakarya University, Medicine Faculty, Sakarya; Department of Internal Medicine, Sakarya University, Medicine Faculty, Sakarya; Department of Hematology, Sakarya University, Medicine Faculty, Sakarya; Department of Internal Medicine, Rize Findikli State Hospital, Rize, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Yaylacı
authors.affiliation: Department of Cardiology, Sakarya University, Medicine Faculty, Sakarya; Department of Internal Medicine, Sakarya University, Medicine Faculty, Sakarya; Department of Hematology, Sakarya University, Medicine Faculty, Sakarya; Department of Internal Medicine, Rize Findikli State Hospital, Rize, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Vatan
authors.affiliation: Department of Cardiology, Sakarya University, Medicine Faculty, Sakarya; Department of Internal Medicine, Sakarya University, Medicine Faculty, Sakarya; Department of Hematology, Sakarya University, Medicine Faculty, Sakarya; Department of Internal Medicine, Rize Findikli State Hospital, Rize, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Gündüz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006349:Heart Valve Diseases / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D006350:Heart Valve Prosthesis; D006801:Humans; D019934:International Normalized Ratio; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome; D014812:Vitamin K / Q000037:antagonists & inhibitors*; D014859:Warfarin / Q000627:therapeutic use*
chemical_list: D000925:Anticoagulants; D014812:Vitamin K; D014859:Warfarin