title: [EFFECT OF 4-METHYLPYRAZOLE ON IMMUNE RESPONSE, FUNCTION OF Th1 AND Th2 LYMPHOCYTES, AND CYTOKINE CONCENTRATION IN RAT BLOOD AFTER ACUTE METHANOL POISONING].
abstract: It was established in experiments on noninbred albino rats that the acute intoxication with methanol (1.0 LD50) decreased cellular and humoral immune responses, Th2-lymphocyte activity (to a greater extent as compared to the function of Th1 cells), reduced the blood concentration of immunoregulatory (IFN-g, IL-2, IL-4) and proinflammatory (TNF, IL-1b, IL-6) cytokines on the average by 36.5% (p < 0.05), and did not affect the content of anti-inflammatory cytokines (IL-10, IL-13). Methanol antidote 4-methylpyrazole (non-competitive inhibitor of alcohol dehydrogenase) administered upon acute intoxication with methanol at a dose of 1.0 DL50 partially reduces the intoxication-induced suppression of humoral and cellular immune response, activity of T-helper cells, and production of IL-4 and restores blood levels of TNF, IL-1b, IFN-γ, IL-4, IL-2, IL-6 to the control values.
authors.forename: P F
authors.initials: PF
authors.lastname: Zabrodskii
authors.forename: V V
authors.initials: VV
authors.lastname: Maslyakov
authors.forename: M S
authors.initials: MS
authors.lastname: Gromov
mesh_terms: D000208:Acute Disease; D000818:Animals; D021461:Animals, Outbred Strains; D000931:Antidotes / Q000494:pharmacology*; D005260:Female; D000077604:Fomepizole; D007111:Immunity, Cellular / Q000187:drug effects; D056724:Immunity, Humoral / Q000187:drug effects; D007371:Interferon-gamma / Q000097:blood; D053583:Interleukin-1beta / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D000432:Methanol / Q000037:antagonists & inhibitors* / Q000097:blood / Q000276:immunology / Q000506:poisoning*; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D018417:Th1 Cells / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D058408:Th1-Th2 Balance / Q000187:drug effects; D018418:Th2 Cells / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D000931:Antidotes; D053583:Interleukin-1beta; D007376:Interleukin-2; D015850:Interleukin-6; D011720:Pyrazoles; D014409:Tumor Necrosis Factor-alpha; D015847:Interleukin-4; D007371:Interferon-gamma; D000077604:Fomepizole; D000432:Methanol