title: Serum YKL-40 and gestational diabetes - an observational cohort study.
abstract: To examine serum YKL-40 in women developing gestational diabetes mellitus (GDM). In the present large observational cohort study of 1179 pregnant women, we determined serum YKL-40 four times during pregnancy (at gestational age 12, 20, 25, and 32 weeks). Pregnancy outcome was obtained from medical records. Sixty-eight women (5.8%) developed GDM. Serum YKL-40 increased from gestational age (GA) 12 weeks and the following weeks in the women who developed GDM and was independent of BMI, parity, and maternal age (OR = 2.69, 95% CI: 1.45-5.00, p = 0.002). No association was found between serum YKL-40 and the oral glucose tolerance test results. In conclusion, YKL-40 significantly increased in pregnant women with GDM compared with women without GDM, probably reflecting the low-grade inflammation of GDM. However, we did not find an association between serum concentrations of YKL-40 in early pregnancy and the development of GDM and thus we conclude that YKL-40 alone is not usable as a biomarker for early prediction of GDM.
authors.affiliation: Department of Obstetrics and Gynecology, Roskilde University Hospital, Roskilde, Denmark.|Molecular Unit, Department of Pathology, Copenhagen University Hospital, Herlev and Gentofte, Denmark.
authors.forename: Dorte
authors.initials: D
authors.lastname: Gybel-Brask
authors.affiliation: Department of Medicine and Oncology, Copenhagen University Hospital, Herlev and Gentofte, Denmark.|Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Julia S
authors.initials: JS
authors.lastname: Johansen
authors.affiliation: Department of Surgical Gastroenterology 360, Hvidovre University Hospital, Copenhagen, Denmark.
authors.forename: Ib J
authors.initials: IJ
authors.lastname: Christiansen
authors.affiliation: Department of Obstetrics and Gynecology, Roskilde University Hospital, Roskilde, Denmark.|Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Lillian
authors.initials: L
authors.lastname: Skibsted
authors.affiliation: Molecular Unit, Department of Pathology, Copenhagen University Hospital, Herlev and Gentofte, Denmark.
authors.forename: Estrid V S
authors.initials: EV
authors.lastname: Høgdall
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood*; D000071451:Chitinase-3-Like Protein 1 / Q000097:blood*; D015331:Cohort Studies; D016640:Diabetes, Gestational / Q000175:diagnosis* / Q000473:pathology*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D044967:Serum / Q000737:chemistry*; D055815:Young Adult
chemical_list: D015415:Biomarkers; C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1
keywords: Pregnancy; YKL-40; biomarker; gestational diabetes mellitus