title: Men at risk for paradoxical adipose hyperplasia after cryolipolysis.
abstract: Cryolipolysis, an aesthetic procedure that reduces adipose tissue by exposure to cold temperature, is generally well tolerated with mild side effects including temporary numbness, erythema, and tenderness. However, as cryolipolysis is gaining popularity and more treatments are being performed, reports of rare adverse events including delayed onset pain and paradoxical adipose hyperplasia (PAH) have been described. Recent studies have suggested that PAH can be more common than expected and have a predilection for males, as a disproportionate number of the cases reported in the literature have occurred in men despite the fact that fewer men are likely to be treated with cryolipolysis. Sexual dimorphism in adipose anatomy may provide insight into the increased susceptibility of men to PAH. Careful patient selection avoiding men with visceral abdominal adipose and firm, nondistensible, fibrous fat may be important to minimize the risk of PAH.
authors.affiliation: Washington Institute of Dermatologic Laser Surgery, Washington, DC, USA.
authors.forename: Terrence C
authors.initials: TC
authors.lastname: Keaney
authors.affiliation: Washington Institute of Dermatologic Laser Surgery, Washington, DC, USA.
authors.forename: Lina I
authors.initials: LI
authors.lastname: Naga
mesh_terms: D000273:Adipose Tissue / Q000473:pathology* / Q000601:surgery*; D003452:Cryosurgery / Q000009:adverse effects*; D006801:Humans; D006965:Hyperplasia / Q000209:etiology; D015187:Lipectomy / Q000009:adverse effects* / Q000379:methods; D008297:Male; D012737:Sex Factors
keywords: cryolipolysis; male; paradoxical adipose hyperplasia