title: Cytotoxic heteroleptic heptacoordinate salan zirconium(iv)-bis-chelates - synthesis, aqueous stability and X-ray structure analysis.
abstract: Herein we report the synthesis and structural characterization of a series of novel Zr(iv)salan complexes. The initial metalation product [(L1)2Zr] is highly water sensitive while ligand exchanged [L1Zr(dipic)] hydrolyses slowly with a bis-hydroxo Zr(iv) species identified by MS as an intermediate. [L1Zr(dipic)] is cytotoxic in the range of cisplatin against two human carcinoma cell lines.
authors.affiliation: Fachbereich Chemie and Konstanz Research School Chemical Biology, Universität Konstanz, Universitätsstr. 10, D-78457 Konstanz, Germany. thomas.huhn@uni-konstanz.de.
authors.forename: Fabian
authors.initials: F
authors.lastname: Schneider
authors.affiliation: Fachbereich Chemie and Konstanz Research School Chemical Biology, Universität Konstanz, Universitätsstr. 10, D-78457 Konstanz, Germany. thomas.huhn@uni-konstanz.de.
authors.forename: Tiankun
authors.initials: T
authors.lastname: Zhao
authors.affiliation: Fachbereich Chemie and Konstanz Research School Chemical Biology, Universität Konstanz, Universitätsstr. 10, D-78457 Konstanz, Germany. thomas.huhn@uni-konstanz.de.
authors.forename: Thomas
authors.initials: T
authors.lastname: Huhn
mesh_terms: D002614:Chelating Agents / Q000138:chemical synthesis*; D018360:Crystallography, X-Ray; D003603:Cytotoxins / Q000138:chemical synthesis*; D004355:Drug Stability; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D014867:Water / Q000737:chemistry*; D015040:Zirconium / Q000737:chemistry*
chemical_list: D002614:Chelating Agents; D003603:Cytotoxins; D014867:Water; D015040:Zirconium