title: Type 2 leprosy reaction with Sweet's syndrome-like presentation.
abstract: Leprosy is a chronic disease characterized by manifestations in the peripheral nerves and skin. The course of the disease may be interrupted by acute phenomena called reactions. This article reports a peculiar case of type 2 leprosy reaction with Sweet's syndrome-like features as the first clinical manifestation of leprosy, resulting in a delay in the diagnosis due to unusual clinical presentation. The patient had clinical and histopathological features reminiscent of Sweet's syndrome associated with clusters of vacuolated histiocytes containing acid-fast bacilli isolated or forming globi. Herein, it is discussed how to recognize type 2 leprosy reaction with Sweet's syndrome features, the differential diagnosis with type 1 leprosy reaction and the treatment options. When this kind of reaction is the first clinical presentation of leprosy, the correct diagnosis might be not suspected clinically, and established only with histopathologic evaluation.
authors.affiliation: Hospital Federal de Bonsucesso (HFB) - Rio de Janeiro (RJ), Brazil.
authors.forename: Francielle Chiavelli
authors.initials: FC
authors.lastname: Chiaratti
authors.affiliation: Hospital Federal de Bonsucesso (HFB) - Rio de Janeiro (RJ), Brazil.
authors.forename: Egon Luiz Rodrigues
authors.initials: EL
authors.lastname: Daxbacher
authors.affiliation: Hospital Federal de Bonsucesso (HFB) - Rio de Janeiro (RJ), Brazil.
authors.forename: Antonielle Borges Faria
authors.initials: AB
authors.lastname: Neumann
authors.affiliation: Hospital Federal de Bonsucesso (HFB) - Rio de Janeiro (RJ), Brazil.
authors.forename: Thiago
authors.initials: T
authors.lastname: Jeunon
mesh_terms: D000328:Adult; D004890:Erythema / Q000175:diagnosis; D005260:Female; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D007917:Leprostatic Agents / Q000627:therapeutic use; D056006:Leprosy, Multibacillary / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D009504:Neutrophils / Q000473:pathology; D011241:Prednisone / Q000627:therapeutic use; D016463:Sweet Syndrome / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D013792:Thalidomide / Q000627:therapeutic use
chemical_list: D007917:Leprostatic Agents; D013792:Thalidomide; D011241:Prednisone