title: Large-Conductance Calcium-Activated Potassium Channels in Glomerulus: From Cell Signal Integration to Disease.
abstract: Large-conductance calcium-activated potassium (BK) channels are currently considered as vital players in a variety of renal physiological processes. In podocytes, BK channels become active in response to stimuli that increase local cytosolic Ca(2+), possibly secondary to activation of slit diaphragm TRPC6 channels by chemical or mechanical stimuli. Insulin increases filtration barrier permeability through mobilization of BK channels. In mesangial cells, BK channels co-expressed with β1 subunits act as a major component of the counteractive response to contraction in order to regulate glomerular filtration. This review aims to highlight recent discoveries on the localization, physiological and pathological roles of BK channels in glomerulus.
authors.affiliation: Department of Nephrology and Central Laboratory, Putuo Hospital, Shanghai University of Traditional Chinese Medicine Shanghai, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Tao
authors.affiliation: Department of Nephrology and Central Laboratory, Putuo Hospital, Shanghai University of Traditional Chinese Medicine Shanghai, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Lan
authors.affiliation: Department of Nephrology and Central Laboratory, Putuo Hospital, Shanghai University of Traditional Chinese Medicine Shanghai, China.
authors.forename: Yunman
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Pharmacology, School of Pharmacy, Fudan University Shanghai, China.
authors.forename: Hongya
authors.initials: H
authors.lastname: Hei
authors.affiliation: Department of Pharmacology, School of Pharmacy, Fudan University Shanghai, China.
authors.forename: Lulu
authors.initials: L
authors.lastname: Tian
authors.affiliation: Department of Pharmacology, School of Pharmacy, Fudan University Shanghai, China.
authors.forename: Wanma
authors.initials: W
authors.lastname: Pan
authors.affiliation: Department of Pharmacology, School of Pharmacy, Fudan University Shanghai, China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Nephrology and Central Laboratory, Putuo Hospital, Shanghai University of Traditional Chinese Medicine Shanghai, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Peng
keywords: BK channels; glomerular filtration; mesangial cells; podocytes; β subunits