title: Euphorbesulins A-P, Structurally Diverse Diterpenoids from Euphorbia esula.
abstract: Aqueous ethanol extracts of powdered twigs of Euphorbia esula afforded 16 new diterpenoids, named euphorbesulins A-P. These euphorbesulins included presegetane (1-3), jatrophane (4-14), paraliane (15), and isopimarane (16) diterpenoids as well as six known analogues. Compounds 1-3 represent a rare type of presegetane diterpenoid. Their structures were determined by analysis of the spectroscopic data, and the absolute configuration of 1 was established by X-ray crystallography. Diterpenoid 7 showed low nanomolar antimalarial activity, while the remaining compounds showed only moderate or no antimalarial activity.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road, Shanghai 201203, People's Republic of China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhou
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road, Shanghai 201203, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Biochemistry and the Virginia Tech Center for Drug Discovery, MC 0308, Virginia Tech , Blacksburg, Virginia 24061, United States.
authors.forename: Seema
authors.initials: S
authors.lastname: Dalal
authors.affiliation: Department of Biochemistry and the Virginia Tech Center for Drug Discovery, MC 0308, Virginia Tech , Blacksburg, Virginia 24061, United States.
authors.forename: Maria B
authors.initials: MB
authors.lastname: Cassera
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road, Shanghai 201203, People's Republic of China.
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Yue
mesh_terms: D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002738:Chloroquine / Q000494:pharmacology; D018360:Crystallography, X-Ray; D060467:Disease Resistance / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D028481:Euphorbia / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010963:Plasmodium falciparum / Q000187:drug effects
chemical_list: D000962:Antimalarials; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; C000617677:euphorbesulin G; D002738:Chloroquine