title: Impact of Diabetes-Specific Nutritional Formulas versus Oatmeal on Postprandial Glucose, Insulin, GLP-1 and Postprandial Lipidemia.
abstract: Diabetes-specific nutritional formulas (DSNFs) are frequently used as part of medical nutrition therapy for patients with diabetes. This study aims to evaluate postprandial (PP) effects of 2 DSNFs; Glucerna (GL) and Ultra Glucose Control (UGC) versus oatmeal (OM) on glucose, insulin, glucagon-like peptide-1 (GLP-1), free fatty acids (FFA) and triglycerides (TG). After an overnight fast, 22 overweight/obese patients with type 2 diabetes were given 200 kcal of each of the three meals on three separate days in random order. Blood samples were collected at baseline and at 30, 60, 90, 120, 180 and 240 min. Glucose area under the curve (AUC0-240) after GL and UGC was lower than OM (p < 0.001 for both). Insulin positive AUC0-120 after UGC was higher than after OM (p = 0.02). GLP-1 AUC0-120 and AUC0-240 after GL and UGC was higher than after OM (p < 0.001 for both). FFA and TG levels were not different between meals. Intake of DSNFs improves PP glucose for 4 h in comparison to oatmeal of similar caloric level. This is achieved by either direct stimulation of insulin secretion or indirectly by stimulating GLP-1 secretion. The difference between their effects is probably related to their unique blends of amino acids, carbohydrates and fat.
authors.affiliation: Joslin Diabetes Center, Boston, MA 02215, USA. adham.mottalib@joslin.harvard.edu.
authors.forename: Adham
authors.initials: A
authors.lastname: Mottalib
authors.affiliation: Joslin Diabetes Center, Boston, MA 02215, USA. Barakatun.Nisak-Mohd-Yusof@joslin.harvard.edu.|Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor 43400, Malaysia. Barakatun.Nisak-Mohd-Yusof@joslin.harvard.edu.
authors.forename: Barakatun-Nisak
authors.initials: BN
authors.lastname: Mohd-Yusof
authors.affiliation: Joslin Diabetes Center, Boston, MA 02215, USA. moshehabeldin@gmail.com.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Shehabeldin
authors.affiliation: Joslin Diabetes Center, Boston, MA 02215, USA. david.pober@joslin.harvard.edu.
authors.forename: David M
authors.initials: DM
authors.lastname: Pober
authors.affiliation: Joslin Diabetes Center, Boston, MA 02215, USA. joanna.mitri@joslin.harvard.edu.
authors.forename: Joanna
authors.initials: J
authors.lastname: Mitri
authors.affiliation: Joslin Diabetes Center, Boston, MA 02215, USA. osama.hamdy@joslin.harvard.edu.
authors.forename: Osama
authors.initials: O
authors.lastname: Hamdy
mesh_terms: D000368:Aged; D018554:Avena / Q000737:chemistry; D015992:Body Mass Index; D018592:Cross-Over Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000178:diet therapy*; D003927:Diet, Diabetic / Q000379:methods; D004038:Diet, Reducing / Q000379:methods; D004040:Dietary Carbohydrates / Q000627:therapeutic use; D004042:Dietary Fats, Unsaturated / Q000627:therapeutic use; D005260:Female; D005526:Food, Formulated; D052216:Glucagon-Like Peptide 1 / Q000097:blood; D006442:Glycated Hemoglobin / Q000032:analysis; D038321:Glycemic Index; D006801:Humans; D006943:Hyperglycemia / Q000517:prevention & control*; D006946:Hyperinsulinism / Q000517:prevention & control*; D006949:Hyperlipidemias / Q000517:prevention & control*; D008297:Male; D062407:Meals; D008875:Middle Aged; D050177:Overweight / Q000150:complications / Q000178:diet therapy*; D012639:Seeds / Q000737:chemistry
chemical_list: D004040:Dietary Carbohydrates; D004042:Dietary Fats, Unsaturated; D052216:Glucagon-Like Peptide 1; D006442:Glycated Hemoglobin; C530986:Glucerna; C517652:hemoglobin A1c protein, human
keywords: clinical nutrition; diabetes; meal replacement; medical food; nutritional formula; obesity