title: Hemodynamic response to burst-suppressed and discontinuous electroencephalography activity in infants with hypoxic ischemic encephalopathy.
abstract: Burst suppression (BS) is an electroencephalographic state associated with a profound inactivation of the brain. BS and pathological discontinuous electroencephalography (EEG) are often observed in term-age infants with neurological injury and can be indicative of a poor outcome and lifelong disability. Little is known about the neurophysiological mechanisms of BS or how the condition relates to the functional state of the neonatal brain. We used simultaneous EEG and diffuse optical tomography (DOT) to investigate whether bursts of EEG activity in infants with hypoxic ischemic encephalopathy are associated with an observable cerebral hemodynamic response. We were able to identify significant changes in concentration of both oxy and deoxyhemoglobin that are temporally correlated with EEG bursts and present a relatively consistent morphology across six infants. Furthermore, DOT reveals patient-specific spatial distributions of this hemodynamic response that may be indicative of a complex pattern of cortical activation underlying discontinuous EEG activity that is not readily apparent in scalp EEG.
authors.affiliation: Cambridge University Hospitals NHS Foundation Trust, The Rosie Hospital, The Evelyn Perinatal Imaging Centre, neoLAB, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0QQ, United Kingdom; Cambridge University Hospitals NHS Foundation Trust, The Rosie Hospital, Department of Neonatology, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0QQ, United Kingdom.
authors.forename: Maria
authors.initials: M
authors.lastname: Chalia
authors.affiliation: Cambridge University Hospitals NHS Foundation Trust, The Rosie Hospital, The Evelyn Perinatal Imaging Centre, neoLAB, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0QQ, United Kingdom; Cambridge University Hospitals NHS Foundation Trust, The Rosie Hospital, Department of Neonatology, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0QQ, United Kingdom.
authors.forename: Chuen Wai
authors.initials: CW
authors.lastname: Lee
authors.affiliation: Cambridge University Hospitals NHS Foundation Trust, The Rosie Hospital, The Evelyn Perinatal Imaging Centre, neoLAB, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0QQ, United Kingdom; University College London, Department of Medical Physics and Biomedical Engineering, Malet Place Engineering Building, Gower Street, London WC1E 6BT, United Kingdom.
authors.forename: Laura A
authors.initials: LA
authors.lastname: Dempsey
authors.affiliation: Cambridge University Hospitals NHS Foundation Trust, The Rosie Hospital, The Evelyn Perinatal Imaging Centre, neoLAB, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0QQ, United Kingdom; Cambridge University Hospitals NHS Foundation Trust, The Rosie Hospital, Department of Neonatology, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0QQ, United Kingdom.
authors.forename: Andrea D
authors.initials: AD
authors.lastname: Edwards
authors.affiliation: Cambridge University Hospitals NHS Foundation Trust, The Rosie Hospital, The Evelyn Perinatal Imaging Centre, neoLAB, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0QQ, United Kingdom; University College London, Department of Medical Physics and Biomedical Engineering, Malet Place Engineering Building, Gower Street, London WC1E 6BT, United Kingdom.
authors.forename: Harsimrat
authors.initials: H
authors.lastname: Singh
authors.affiliation: Cambridge University Hospitals NHS Foundation Trust , Department of Clinical Neurophysiology, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0QQ, United Kingdom.
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Michell
authors.affiliation: Cambridge University Hospitals NHS Foundation Trust, The Rosie Hospital, The Evelyn Perinatal Imaging Centre, neoLAB, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0QQ, United Kingdom; University College London, Department of Medical Physics and Biomedical Engineering, Malet Place Engineering Building, Gower Street, London WC1E 6BT, United Kingdom.
authors.forename: Nicholas L
authors.initials: NL
authors.lastname: Everdell
authors.affiliation: University College London , Department of Medical Physics and Biomedical Engineering, Malet Place Engineering Building, Gower Street, London WC1E 6BT, United Kingdom.
authors.forename: Reuben W
authors.initials: RW
authors.lastname: Hill
authors.affiliation: Cambridge University Hospitals NHS Foundation Trust, The Rosie Hospital, The Evelyn Perinatal Imaging Centre, neoLAB, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0QQ, United Kingdom; University College London, Department of Medical Physics and Biomedical Engineering, Malet Place Engineering Building, Gower Street, London WC1E 6BT, United Kingdom.
authors.forename: Jeremy C
authors.initials: JC
authors.lastname: Hebden
authors.affiliation: Cambridge University Hospitals NHS Foundation Trust, The Rosie Hospital, The Evelyn Perinatal Imaging Centre, neoLAB, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0QQ, United Kingdom; Cambridge University Hospitals NHS Foundation Trust, The Rosie Hospital, Department of Neonatology, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0QQ, United Kingdom.
authors.forename: Topun
authors.initials: T
authors.lastname: Austin
authors.affiliation: Cambridge University Hospitals NHS Foundation Trust, The Rosie Hospital, The Evelyn Perinatal Imaging Centre, neoLAB, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0QQ, United Kingdom; University College London, Department of Medical Physics and Biomedical Engineering, Malet Place Engineering Building, Gower Street, London WC1E 6BT, United Kingdom.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Cooper
keywords: burst suppression; diffuse optical imaging; diffuse optical tomography; discontinuous; electroencephalography; hemodynamic response function; hypoxic ischemic encephalopathy