title: Environmental impact assessment of veterinary drug on fish aquaculture for food safety.
abstract: The degradation of veterinary drugs approved for use in aquaculture is very important in the evaluation of the impact of these drugs on the environment and to ensure safe food production. The purpose of this study is to provide guidance on how the interpretation of environmental fate data can be used by applicants to aid in protecting the environment and for the basis for food production, by suggesting the correct interpretation of data as part of an effective registration process. Tests were performed using a modification of the Organisation for Economic Co-operation and Development (OECD) 308 guideline using erythromycin and oxolinic acid under combinations of aerobic and anaerobic conditions, with and without sediment, in sea water and fresh water. Estimated DT50 s of erythromycin in fresh and sea water ranged from 6.8 to 37.9 days and estimated DT90 s were from 22.6 to 125.9 days. Degradation was more rapid in fresh water than in sea water with the formation of three degradation products: anhydroerythomycin A, erythromycin A enol ether, and pseudoerythomycin A enol ether. Estimated DT50 s of oxolinic acid in fresh and sea water were from 10.3 to 63.0 days and estimated DT90 s were from 34.3 to 209.4 days which suggests that oxolinic acid is more persistent in the environment than erythromycin. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Centre for Food and Drug Analysis, Busan Regional Food and Drug Administration, Ministry of Food and Drug Safety (MFDS), Busan, Rep. of Korea.
authors.forename: Jin-Wook
authors.initials: JW
authors.lastname: Kwon
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis*; D004784:Environmental Monitoring / Q000379:methods*; D004917:Erythromycin / Q000032:analysis*; D005393:Fish Diseases / Q000517:prevention & control; D005398:Fisheries; D005399:Fishes; D059022:Food Safety; D005618:Fresh Water / Q000032:analysis; D006801:Humans; D010093:Oxolinic Acid / Q000032:analysis*; D012623:Seawater / Q000032:analysis; D019155:Veterinary Drugs / Q000032:analysis*; D014874:Water Pollutants, Chemical / Q000032:analysis*
chemical_list: D000900:Anti-Bacterial Agents; D019155:Veterinary Drugs; D014874:Water Pollutants, Chemical; D004917:Erythromycin; D010093:Oxolinic Acid
keywords: OECD 308 Test Guideline; aquaculture; environmental fate; environmental sustainability; veterinary drug