title: mRNA-Based Therapeutics - Advances and Perspectives.
abstract: In this review we discuss features of mRNA synthesis and modifications used to minimize immune response and prolong efficiency of the translation process in vivo. Considerable attention is given to the use of liposomes and nanoparticles containing lipids and polymers for the mRNA delivery. Finally we briefly discuss mRNAs which are currently in the clinical trials for cancer immunotherapy, vaccination against infectious diseases, and replacement therapy.
authors.affiliation: Lomonosov Moscow State University, Department of Chemistry, Moscow, 119991, Russia. olga.sergeeva.v@gmail.com.
authors.forename: O V
authors.initials: OV
authors.lastname: Sergeeva
authors.forename: V E
authors.initials: VE
authors.lastname: Koteliansky
authors.forename: T S
authors.initials: TS
authors.lastname: Zatsepin
mesh_terms: D000818:Animals; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D007113:Immunity, Innate; D007167:Immunotherapy; D008081:Liposomes / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry; D009369:Neoplasms / Q000276:immunology / Q000628:therapy; D012333:RNA, Messenger / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D014611:Vaccination
chemical_list: D004337:Drug Carriers; D008081:Liposomes; D012333:RNA, Messenger