title: Brain perfusion: computed tomography and magnetic resonance techniques.
abstract: Cerebral perfusion imaging provides assessment of regional microvascular hemodynamics in the living brain, enabling in vivo measurement of a variety of different hemodynamic parameters. Perfusion imaging techniques that are used in the clinical setting usually rely upon X-ray computed tomography (CT) or magnetic resonance imaging (MRI). This chapter reviews CT- and MRI-based perfusion imaging techniques, with attention to image acquisition, clinically relevant aspects of image postprocessing, and fundamental differences between CT- and MRI-based techniques. Correlations with cerebrovascular physiology and potential clinical applications of perfusion imaging are reviewed, focusing upon the two major classes of neurologic disease in which perfusion imaging is most often performed: primary perfusion disorders (including ischemic stroke, transient ischemic attack, and reperfusion syndrome), and brain tumors.
authors.affiliation: Division of Neuroradiology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: wcopen@partners.org.
authors.forename: William A
authors.initials: WA
authors.lastname: Copen
authors.affiliation: Division of Neuroradiology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
authors.forename: Michael H
authors.initials: MH
authors.lastname: Lev
authors.affiliation: Division of Neuroradiology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
authors.forename: Otto
authors.initials: O
authors.lastname: Rapalino
mesh_terms: D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging / Q000502:physiology; D001927:Brain Diseases / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D014057:Tomography, X-Ray Computed
keywords: brain; brain ischemia; brain neoplasms; diagnostic imaging; hemodynamics; ischemic attack (transient); magnetic resonance imaging; tomography (X-ray computed)