title: Chemical Variability and Biological Activities of Essential Oils of Micromeria inodora (Desf.) Benth. from Algeria.
abstract: The chemical composition of the essential oils isolated from the aerial parts of Micromeria inodora (Desf.) Benth. collected in 24 Algerian localities was investigated from the first time using GC-FID, GC/MS and13C-NMR. Altogether, 83 components which accounted for 94.7% of the total oil composition were identified. The main compounds were trans-sesquisabinene hydrate (1; 20.9%), α-terpinyl acetate (2; 19.8%), globulol (3; 4.9%), caryophyllene oxide (4; 4.3%), β-bisabolol (5; 2.9%) and trans-7-epi-sesquisabinene hydrate (6; 2.6%). Comparison with the literature highlighted the originality of the Algerian M. inodora oil and indicated that 1 might be used as taxonomical marker. The study of the chemical variability allowed the discrimination of two main clusters confirming that there is a relation between the essential-oil compositions and the soil nature of the harvest locations. Biological activity of M. inodora essential oil was assessed against fourteen species of microorganisms involved in nosocomial infections using paper disc diffusion and dilution agar assays. The in vitro study demonstrated a good activity against Gram-positive strains such as Staphylococcus aureus, Bacillus cereus, Bacillus subtilis, and Enterococcus faecalis, and moderate activity against Candida albicans. These results might be useful for the future commercial valorization of M. inodora essential oil as a promising source of natural products with potential against various nosocomial community and toxinic infections.
authors.affiliation: Laboratoire de Chimie Organique Substances Naturelles et Analyses (COSNA), Département de Chimie, Faculté des Sciences, Université de Tlemcen, BP 119, Tlemcen, 13000, Algérie.|Laboratoire Chimie des Produits Naturels (CPN), UMR CNRS 6134, Université de Corse, Campus Grimaldi, BP 52, FR-20250, Corte.
authors.forename: Fatima Zahra
authors.initials: FZ
authors.lastname: Benomari
authors.affiliation: Laboratoire de Chimie Organique Substances Naturelles et Analyses (COSNA), Département de Chimie, Faculté des Sciences, Université de Tlemcen, BP 119, Tlemcen, 13000, Algérie.
authors.forename: Nassim
authors.initials: N
authors.lastname: Djabou
authors.affiliation: Laboratoire de Chimie Organique Substances Naturelles et Analyses (COSNA), Département de Chimie, Faculté des Sciences, Université de Tlemcen, BP 119, Tlemcen, 13000, Algérie.|Laboratoire Chimie des Produits Naturels (CPN), UMR CNRS 6134, Université de Corse, Campus Grimaldi, BP 52, FR-20250, Corte.
authors.forename: Ali
authors.initials: A
authors.lastname: Medbouhi
authors.affiliation: Laboratoire de Microbiologie Appliquée à l'Agroalimentaire, au Biomédical et à l'Environnement (LAMAABE), Faculté SNV-STU, Université de Tlemcen, BP 119, Tlemcen, 13000, Algérie.
authors.forename: Abdelmounaim
authors.initials: A
authors.lastname: Khadir
authors.affiliation: Laboratoire de Microbiologie Appliquée à l'Agroalimentaire, au Biomédical et à l'Environnement (LAMAABE), Faculté SNV-STU, Université de Tlemcen, BP 119, Tlemcen, 13000, Algérie.
authors.forename: Mourad
authors.initials: M
authors.lastname: Bendahou
authors.affiliation: Laboratoire de Substances Naturelles et Bioactives (LASNABIO), Département de Chimie, Faculté des Sciences, Université de Tlemcen, BP 119, Tlemcen, 13000, Algérie.
authors.forename: Chaouki
authors.initials: C
authors.lastname: Selles
authors.affiliation: Laboratoire Chimie des Produits Naturels (CPN), UMR CNRS 6134, Université de Corse, Campus Grimaldi, BP 52, FR-20250, Corte.
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Desjobert
authors.affiliation: Laboratoire Chimie des Produits Naturels (CPN), UMR CNRS 6134, Université de Corse, Campus Grimaldi, BP 52, FR-20250, Corte.
authors.forename: Jean
authors.initials: J
authors.lastname: Costa
authors.affiliation: Laboratoire Chimie des Produits Naturels (CPN), UMR CNRS 6134, Université de Corse, Campus Grimaldi, BP 52, FR-20250, Corte.
authors.forename: Alain
authors.initials: A
authors.lastname: Muselli
mesh_terms: D000462:Algeria; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D019686:Lamiaceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009822:Oils, Volatile / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D009822:Oils, Volatile
keywords: Biological activity; Chemical variability; Environmental chemistry; Essential oils; Micromeria inodora (Desf.) Benth.