title: Staphylococcus aureus Pathogenesis: The Importance of Reduced Cytotoxicity.
abstract: Toxin production clearly contributes to the pathogenesis of Staphylococcus aureus, but that does not mean it is always in the best interest of the pathogen. Indeed, the ability to limit toxin production may provide an important mechanism for persistence, dissemination, and development of invasive disease within an individual human host.
authors.affiliation: Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, 4301W. Markham, Little Rock, AR 72205, USA. Electronic address: smeltzermarks@uams.edu.
authors.forename: Mark S
authors.initials: MS
authors.lastname: Smeltzer
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics; D018441:Biofilms / Q000254:growth & development; D004768:Enterotoxins / Q000378:metabolism*; D054884:Host-Pathogen Interactions; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000472:pathogenicity*; D013203:Staphylococcal Infections / Q000382:microbiology / Q000473:pathology*; D015534:Trans-Activators / Q000235:genetics
chemical_list: C095698:Agr protein, Staphylococcus aureus; D001426:Bacterial Proteins; D004768:Enterotoxins; D015534:Trans-Activators
keywords: SSR42; Staphylococcus aureus; cytotoxicity; intracellular persistence; rsp