title: Immunity-Related Protein Expression and Pathological Lung Damage in Mice Poststimulation with Ambient Particulate Matter from Live Bird Markets.
abstract: The objective of this study was to obtain insight into the adverse health effects of airborne particulate matter (PM) collected from live bird markets and to determine whether biological material in PM accounts for immune-related inflammatory response. Mice were exposed to a single or repeated dose of PM, after which the expression of toll-like receptors (TLRs), cytokines, and chemokines in the lungs of infected mice were examined by enzyme-linked immunosorbent assay and histopathological analysis. Results after single and repeated PM stimulation with [Formula: see text] indicated that TLR2 and TLR4 played a dominant role in the inflammatory responses of the lung. Further analysis demonstrated that the expression levels of IL-1β, TNF-α, IFN-γ, IL-8, IP-10, and MCP-1 increased significantly, which could eventually contribute to lung injury. Moreover, biological components in PM were critical in mediating immune-related inflammatory responses and should therefore not be overlooked.
authors.affiliation: Sino-German Cooperative Research Centre for Zoonosis of Animal Origin Shandong Province, College of Veterinary Medicine, Shandong Agricultural University, Tai'an, China; Collaborative Innovation Centre for the Origin and Control of Emerging Infectious Diseases, Taishan Medical College, Tai'an, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Meng
authors.affiliation: Sino-German Cooperative Research Centre for Zoonosis of Animal Origin Shandong Province, College of Veterinary Medicine, Shandong Agricultural University , Tai'an , China.
authors.forename: Bo
authors.initials: B
authors.lastname: Wu
authors.affiliation: Taian Central Hospital , Tai'an , China.
authors.forename: Jing
authors.initials: J
authors.lastname: Gao
authors.affiliation: Sino-German Cooperative Research Centre for Zoonosis of Animal Origin Shandong Province, College of Veterinary Medicine, Shandong Agricultural University , Tai'an , China.
authors.forename: Yumei
authors.initials: Y
authors.lastname: Cai
authors.affiliation: Zaozhuang Vocational College , Shandong , China.
authors.forename: Meiling
authors.initials: M
authors.lastname: Yao
authors.affiliation: Sino-German Cooperative Research Centre for Zoonosis of Animal Origin Shandong Province, College of Veterinary Medicine, Shandong Agricultural University, Tai'an, China; Collaborative Innovation Centre for the Origin and Control of Emerging Infectious Diseases, Taishan Medical College, Tai'an, China.
authors.forename: Liangmeng
authors.initials: L
authors.lastname: Wei
authors.affiliation: Sino-German Cooperative Research Centre for Zoonosis of Animal Origin Shandong Province, College of Veterinary Medicine, Shandong Agricultural University, Tai'an, China; Collaborative Innovation Centre for the Origin and Control of Emerging Infectious Diseases, Taishan Medical College, Tai'an, China.
authors.forename: Tongjie
authors.initials: T
authors.lastname: Chai
keywords: biological material; immunity-related protein; live bird market; lung injury; particulate matter