title: Myxovirus resistance 1 gene polymorphisms and outcomes of viral hepatitis B and C infections in Moroccan patients.
abstract: Host genetic factors may influence the establishment of chronicity or spontaneous clearance in viral hepatitis B and C infections. More light was shed on the role played by interferon-stimulated genes in the innate immunity. Myxovirus resistance 1 (MX1) is one of those key genes that have reported to inhibit several viruses. The present study aims to explore the possible association of -88G/T and -123C/A promoter variants of MX1 with susceptibility to chronic hepatitis B and C and/or with spontaneous clearance in a Moroccan population. The -88G/T and -123C/A SNPs were genotyped by PCR-RFLP in 538 individuals stratified into HBV chronically infected patients (n = 120), HCV-chronically infected patients (n = 115), HBV spontaneously resolved subjects (n = 114), HCV spontaneously resolved group (n = 52), and healthy controls (n = 137). A significant association of -123C allele with HBV spontaneous clearance has been found (P = 0.002, OR = 2.34; 95%CI [1.36-4]). In addition, a significant correlation between the MX1-GC haplotype and HBV spontaneous clearance (P < 0.001) was found. No significant association of -88G/T and -123C/A polymorphisms with regard to HCV infection was observed in this study. Here, we show that for North African patients with chronic hepatitis, MX1 gene variation at position -123 may influence the outcome of HBV infection but not HCV infection. J. Med. Virol. 89:647-652, 2017. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Virology Unit, Viral Hepatitis Laboratory, Institut Pasteur du Maroc., Casablanca, Morocco.
authors.forename: Khadija
authors.initials: K
authors.lastname: Rebbani
authors.affiliation: Virology Unit, Viral Hepatitis Laboratory, Institut Pasteur du Maroc., Casablanca, Morocco.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Ababou
authors.affiliation: Laboratoire de génétique médicale et de pathologie moléculaire, Faculté de Médecine et de Pharmacie, Casablanca, Morocco.
authors.forename: Sellama
authors.initials: S
authors.lastname: Nadifi
authors.affiliation: Equipe d'Anthropogénétique et biotechnologies, Faculté des Sciences, Université Chouaïb Doukkali., El Jadida, Morocco.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Kandil
authors.affiliation: Unité «Organisation nucléaire et oncogenèse», INSERM U993, Institut Pasteur, Paris, France.
authors.forename: Agnès
authors.initials: A
authors.lastname: Marchio
authors.affiliation: Unité «Organisation nucléaire et oncogenèse», INSERM U993, Institut Pasteur, Paris, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Pineau
authors.affiliation: Virology Unit, Viral Hepatitis Laboratory, Institut Pasteur du Maroc., Casablanca, Morocco.
authors.forename: Sayeh
authors.initials: S
authors.lastname: Ezzikouri
authors.affiliation: Virology Unit, Viral Hepatitis Laboratory, Institut Pasteur du Maroc., Casablanca, Morocco.
authors.forename: Soumaya
authors.initials: S
authors.lastname: Benjelloun
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D020022:Genetic Predisposition to Disease; D060005:Genotyping Techniques; D019694:Hepatitis B, Chronic / Q000235:genetics*; D019698:Hepatitis C, Chronic / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009018:Morocco; D064547:Myxovirus Resistance Proteins / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D055815:Young Adult
chemical_list: C579071:MX1 protein, human; D064547:Myxovirus Resistance Proteins
keywords: hepatitis B; hepatitis C; interferon-stimulated genes; polymorphism; spontaneous clearance