title: IncreasedTrypanosoma bruceicathepsin-L activity inhibits human serum-mediated trypanolysis.
abstract: Most African trypanosomes, including the veterinary speciesTrypanosoma brucei bruceiandT. congolenseare susceptible to lysis by human serum. A recent study by Alsfordet al.[PLoS Pathogens (2014) 10, e1004130] has identified aT. b. bruceilysosomal cathepsin with an inhibitory effect on human serum's trypanolytic action.
authors.affiliation: London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
authors.forename: Sam
authors.initials: S
authors.lastname: Alsford
keywords: Trypanosoma brucei; cathepsin-L; innate immunity; lysosome; trypanolysis