title: One-Pot Synthesis of Fe3O4@PS@P(AEMH-FITC) Magnetic Fluorescent Nanocomposites for Bimodal Imaging.
abstract: Magnetic fluorescent nanocomposites have attracted much attention because of their merging magnetic and fluorescent properties for biomedical application. However, the procedure of synthesis of magnetic fluorescent nanocomposites is always complicated. In addition, the properties of fluorescent component could be easily influenced by magnetic component, retaining both of the magnetic and fluorescent properties into one single nanoparticle considered to be a significant challenge. Herein, we report one-pot method to synthesize multifunctional magnetic fluorescent Fe3O4@PS@P(AEMH-FITC) nanocomposites for bimodal imaging. The asprepared Fe3O4@PS@P(AEMH-FITC) nanocomposites with well-define spherical core/shell structure were stable properties. Moreover, the Fe3O4@PS@P(AEMH-FITC) nanocomposites displayed efficient fluorescent and magnetic properties, respectively. Meanwhile, the magnetic resonance imaging (MRI) and HePG2 cancer cell fluorescent images experiment results suggested that Fe3O4@PS@P(AEMH-FITC) nanocomposites could be used as MRI contrast agents and Fluorescence Imaging (FLI) agents for bioimaging application. Our investigation paves a facile avenue for synthesized magnetic fluorescent nanostructures with well biocompatibility for potential bioimaging application in MRI and FLI.
authors.forename: Xuandong
authors.initials: X
authors.lastname: Wang
authors.forename: Huiyu
authors.initials: H
authors.lastname: Liu
authors.forename: Ren
authors.initials: R
authors.lastname: Jun
authors.forename: Changhui
authors.initials: C
authors.lastname: Fu
authors.forename: Linlin
authors.initials: L
authors.lastname: Li
authors.forename: Tianlong
authors.initials: T
authors.lastname: Li
authors.forename: Fangqiong
authors.initials: F
authors.lastname: Tang
authors.forename: Xianwei
authors.initials: X
authors.lastname: Meng
mesh_terms: D052203:Ferrosoferric Oxide / Q000737:chemistry*; D016650:Fluorescein-5-isothiocyanate / Q000737:chemistry*; D005453:Fluorescence; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008280:Magnetics; D046529:Microscopy, Electron, Transmission; D053761:Nanocomposites; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D016650:Fluorescein-5-isothiocyanate; D052203:Ferrosoferric Oxide