title: Calcium silicate-based drug delivery systems.
abstract: Compared with other inorganic materials such as silica, metal oxides, noble metals and carbon, calcium silicate-based materials, especially nanostructured calcium silicate materials, have high biocompatibility, bioactivity and biodegradability, high specific surface area, nanoporous/hollow structure, high drug-loading capacity, pH-responsive drug release behavior and desirable drug release properties, and thus they are promising for the application in drug delivery. Calcium silicate-based drug delivery systems have a long drug-release time, which can significantly prolong the therapeutic effect of drugs. Another advantage of calcium silicate-based drug delivery systems is their pH-responsive drug release property, which can act as an ideal platform for targeted drug delivery. Areas covered: In recent years, studies have been carried out on calcium silicate-based drug delivery systems, and important results and insights have been documented. This article is not intended to offer a comprehensive review on the research on calcium silicate-based drug delivery systems, but presents some examples reported in the literature, and includes new insights obtained by tracking the interactions between drug molecules and calcium silicate carriers on the molecular level using the synchrotron-based X-ray spectroscopy. Expert opinion: Finally, our opinions on calcium silicate-based drug delivery systems are provided, and several research directions for the future studies are proposed.
authors.affiliation: a State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics , Chinese Academy of Sciences , Shanghai , P. R. China.
authors.forename: Ying-Jie
authors.initials: YJ
authors.lastname: Zhu
authors.affiliation: b Department of Chemistry , University of Western Ontario , London , ON , Canada.
authors.forename: Xiao-Xuan
authors.initials: XX
authors.lastname: Guo
authors.affiliation: b Department of Chemistry , University of Western Ontario , London , ON , Canada.
authors.forename: Tsun-Kong
authors.initials: TK
authors.lastname: Sham
mesh_terms: D017610:Calcium Compounds / Q000737:chemistry*; D016503:Drug Delivery Systems; D049329:Nanostructures; D010087:Oxides / Q000737:chemistry; D017640:Silicates / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry
chemical_list: D017610:Calcium Compounds; D010087:Oxides; D017640:Silicates; D012822:Silicon Dioxide; C031293:calcium silicate
keywords: Calcium silicate; drug delivery; nanostructured materials; synchrotron spectroscopy