title: Spleen Uptake on Bone Scan After Frequent Platelet and RBC Transfusions.
abstract: A 21-year-old man, allogeneic hematopoietic stem cell transplantation recipient, was referred to our nuclear medicine department for a suspicion of knee osteonecrosis. Bone scan with Tc-HMDP did not show abnormal bone uptake but an intense spleen accumulation. F-FDG PET/CT performed on the same day showed no pathological spleen uptake. The patient had secondary hemochromatosis resulting from frequent transfusions in the setting of a chronic graft versus host disease with hemolysis and thrombocytopenia. The last RBC and platelet transfusions were performed 9 and 2 days before the examination, respectively. Secondary hemochromatosis and recent transfusions may explain our findings.
authors.affiliation: From the *Service de Biophysique et Médecine Nucléaire, and †Service d'Onco-hématologie, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg; ‡ICube, Université de Strasbourg/CNRS UMR 7357; and §FMTS-Faculté de Médecine, Strasbourg, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: De Marini
authors.forename: Annegret
authors.initials: A
authors.lastname: Laplace
authors.forename: Julien
authors.initials: J
authors.lastname: Matuszak
authors.forename: Luc-Matthieu
authors.initials: LM
authors.lastname: Fornecker
authors.forename: Izzie Jacques
authors.initials: IJ
authors.lastname: Namer
mesh_terms: D001842:Bone and Bones / Q000000981:diagnostic imaging; D017707:Erythrocyte Transfusion / Q000009:adverse effects*; D019788:Fluorodeoxyglucose F18; D006086:Graft vs Host Disease / Q000000981:diagnostic imaging*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D008297:Male; D017713:Platelet Transfusion / Q000009:adverse effects*; D000072078:Positron Emission Tomography Computed Tomography; D019275:Radiopharmaceuticals; D013154:Spleen / Q000000981:diagnostic imaging*; D013669:Technetium Tc 99m Medronate / Q000031:analogs & derivatives; D055815:Young Adult
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; C024226:technetium Tc 99m hydroxymethylene diphosphonate; D013669:Technetium Tc 99m Medronate