title: Death Associated Protein Kinase 1 (DAPK1): A Regulator of Apoptosis and Autophagy.
abstract: Death-Associated Protein Kinase 1 (DAPK1) belongs to a family of five serine/threonine (Ser/Thr) kinases that possess tumor suppressive function and also mediate a wide range of cellular processes, including apoptosis and autophagy. The loss and gain-of-function of DAPK1 is associated with various cancer and neurodegenerative diseases respectively. In recent years, mechanistic studies have broadened our knowledge of the molecular mechanisms involved in DAPK1-mediated autophagy/apoptosis. In the present review, we have discussed the structural information and various cellular functions of DAPK1 in a comprehensive manner.
authors.affiliation: Apoptosis and Cell Survival Research Laboratory, Department of Bio-Sciences, School of Bio Sciences and Technology, Vellore Institute of Technology (VIT) University Vellore, Tamil Nadu, India.
authors.forename: Pratibha
authors.initials: P
authors.lastname: Singh
authors.affiliation: Apoptosis and Cell Survival Research Laboratory, Department of Bio-Sciences, School of Bio Sciences and Technology, Vellore Institute of Technology (VIT) University Vellore, Tamil Nadu, India.
authors.forename: Palaniyandi
authors.initials: P
authors.lastname: Ravanan
authors.affiliation: Apoptosis and Cell Survival Research Laboratory, Department of Bio-Sciences, School of Bio Sciences and Technology, Vellore Institute of Technology (VIT) University Vellore, Tamil Nadu, India.
authors.forename: Priti
authors.initials: P
authors.lastname: Talwar
keywords: apoptosis; autophagy; cancer; death-associated protein kinase 1; neurodegenerative disease