title: Somatosensory temporal discrimination threshold in Parkinson's disease parallels disease severity and duration.
abstract: To investigate whether the somatosensory temporal discrimination threshold (STDT) is already altered at the clinical onset of Parkinson's disease (PD) and whether STDT abnormalities correlate with disease progression we tested STDT values in patients with different severity of disease.
  
  
  
  We prospectively and consecutively enrolled 63 PD patients: 26 drug-naive PD patients with symptom onset no longer than two years prior to inclusion in the study (early-phase), 37 PD patients with varying degrees of disease severity and 51 age-matched healthy subjects. The STDT was tested on the index finger of both hands, and on both sides of the face. Twelve out of 26 early phase PD patients were re-tested two years after the initial diagnosis.
  
  
  
  PD patients as a whole displayed higher STDT values than healthy subjects. STDT values did not significantly differ between early-phase PD patients and healthy subjects, whereas they were significantly higher in patients with mild/moderate and advanced PD. In early-phase PD patients STDT values at the two years-follow up assessment did not statistically differ from those obtained at baseline. Considering the whole group of PD patients STDT abnormalities significantly correlated with duration and severity of the disease.
  
  
  
  STDT increases as disease progresses. In early-phase PD patients STDT values are still statistically similar to those of healthy subjects, thus implying that dopaminergic depletion alone may not be sufficient to cause STDT abnormalities.
  
  
  
  Our study gives new insight into the sensory abnormalities in PD.
authors.affiliation: IRCCS Neuromed, Pozzilli (IS), Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Conte
authors.affiliation: Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Leodori
authors.affiliation: IRCCS Neuromed, Pozzilli (IS), Italy.
authors.forename: Gina
authors.initials: G
authors.lastname: Ferrazzano
authors.affiliation: Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy.
authors.forename: Maria I
authors.initials: MI
authors.lastname: De Bartolo
authors.affiliation: Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy.
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Manzo
authors.affiliation: IRCCS Neuromed, Pozzilli (IS), Italy; Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Fabbrini
authors.affiliation: IRCCS Neuromed, Pozzilli (IS), Italy; Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy. Electronic address: alfredo.berardelli@uniroma1.it.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Berardelli
mesh_terms: D000368:Aged; D004192:Discrimination, Psychological / Q000502:physiology; D018450:Disease Progression; D005073:Evoked Potentials, Somatosensory / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis* / Q000503:physiopathology*; D011446:Prospective Studies; D012720:Severity of Illness Index; D013003:Somatosensory Cortex / Q000503:physiopathology*; D013997:Time Factors
keywords: Disease progression; Early-phase; Parkinson’s disease; Somatosensory temporal discrimination