title: Association of Renalase SNPs rs2296545 and rs2576178 with the Risk of Hypertension: A Meta-Analysis.
abstract: OBJECTIVE
  Two renalase single nucleotide polymorphisms (SNPs) rs2296545 and rs2576178 have been reported to be associated with the susceptibility to hypertension (HT). Given the inconsistent results, we conducted a meta-analysis to assess the association between these two SNPs and the risk of HT.
  
  
  METHODS
  Electronic databases were systematically searched to find relevant studies. Subgroup analysis was conducted according to the different concomitant diseases and ethnicities in the study population. Pooled odds ratios (OR) and 95% confidence intervals (CI) were calculated using fixed-effect or random-effect models.
  
  
  RESULTS
  A total of six case-control studies on rs2296545 and six studies on rs2576178 were included. In the combined analysis, results showed a significant association between SNP rs2296545 and risk of HT in all genetic models (dominant model CG+CC/GG: OR = 1.43, 95% CI = 1.24-1.65; recessive model CC/CG+GG: OR = 1.36, 95% CI = 1.09-1.69; codominant model CC/GG: OR = 1.63, 95% CI = 1.20-2.20, CG/GG: OR = 1.30, 95% CI = 1.12-1.52; allelic model C/G: OR = 1.29, 95% CI = 1.10-1.51). In subgroup analysis, we observed a significant association between rs2296545 and risk of essential HT. Although we did not observe an association between rs2576178 polymorphism and HT in the combined analysis, an increased risk was observed in the essential HT patients versus healthy controls (subgroup 1) analysis under the dominant, recessive, and codominant genetic models.
  
  
  CONCLUSIONS
  Renalase gene rs2296545 polymorphism is significantly associated with increased risk of HT, whereas rs2576178 polymorphism may not be associated with the susceptibility to HT.
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Medical School, Xi'an Jiaotong University, Xi'an, China.|Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi'an, China.
authors.forename: Yong-Bo
authors.identifier: http://orcid.org/0000-0002-1759-8673
authors.initials: YB
authors.lastname: Lv
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Medical School, Xi'an Jiaotong University, Xi'an, China.|Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi'an, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Medical School, Xi'an Jiaotong University, Xi'an, China.|Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi'an, China.
authors.forename: Wang-Ge
authors.initials: WG
authors.lastname: Ma
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Medical School, Xi'an Jiaotong University, Xi'an, China.|Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi'an, China.
authors.forename: Ding-Yi
authors.initials: DY
authors.lastname: Yan
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Medical School, Xi'an Jiaotong University, Xi'an, China.|Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi'an, China.
authors.forename: Wen-Ling
authors.initials: WL
authors.lastname: Zheng
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Medical School, Xi'an Jiaotong University, Xi'an, China.|Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi'an, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Chu
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Medical School, Xi'an Jiaotong University, Xi'an, China.|Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi'an, China.
authors.forename: Tong-Shuai
authors.initials: TS
authors.lastname: Guo
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Medical School, Xi'an Jiaotong University, Xi'an, China.|Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi'an, China.
authors.forename: Zu-Yi
authors.initials: ZY
authors.lastname: Yuan
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Medical School, Xi'an Jiaotong University, Xi'an, China.|Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi'an, China.
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Mu
mesh_terms: D044466:Asian People; D000075222:Essential Hypertension; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000473:pathology; D008297:Male; D008995:Monoamine Oxidase / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D008995:Monoamine Oxidase; C521557:renalase