title: Fulminant Type 1 Diabetes Mellitus Presenting 11 Days after Delivery in a Patient of Mixed Genetic Background.
abstract: The patient was a 25-year-old woman whose paternal family was Japanese, maternal grandfather was Filipino, and maternal grandmother was Chinese. Eleven days after delivery, she presented with excessive thirst and disturbed consciousness due to diabetic ketoacidosis. She was diagnosed as having fulminant type 1 diabetes associated with pregnancy (PF). The antibody concentration against glutamic acid decarboxylase was 1.2 (<1.5) U/mL, and human leukocyte antigen (HLA) class II haplotypes were DRB1*04:10-DQB1*03:02 and DRB1*15:02-DQB1*05:01. The present case had unique HLA class II haplotypes that have not been previously reported in association with PF.
authors.affiliation: Department of Endocrinology and Metabolism, Tsukuba University Hospital Mito Clinical Education and Training Center, Mito Kyodo General Hospital, Japan.
authors.forename: Shoko
authors.initials: S
authors.lastname: Furukawa
authors.forename: Kazuya
authors.initials: K
authors.lastname: Fujihara
authors.forename: Ryo
authors.initials: R
authors.lastname: Kumagai
authors.forename: Momoko
authors.initials: M
authors.lastname: Isono
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Yagyu
mesh_terms: D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000145:classification* / Q000175:diagnosis* / Q000276:immunology; D016640:Diabetes, Gestational / Q000145:classification* / Q000175:diagnosis*; D016883:Diabetic Ketoacidosis / Q000378:metabolism; D005260:Female; D000068617:Genetic Background; D005968:Glutamate Decarboxylase / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology; D006239:Haplotypes; D006801:Humans; D011247:Pregnancy
chemical_list: D006680:HLA Antigens; D005968:Glutamate Decarboxylase