title: PIF4 Integrates Multiple Environmental and Hormonal Signals for Plant Growth Regulation in Arabidopsis.
abstract: As sessile organisms, plants must be able to adapt to the environment. Plants respond to the environment by adjusting their growth and development, which is mediated by sophisticated signaling networks that integrate multiple environmental and endogenous signals. Recently, increasing evidence has shown that a bHLH transcription factor PIF4 plays a major role in the multiple signal integration for plant growth regulation. PIF4 is a positive regulator in cell elongation and its activity is regulated by various environmental signals, including light and temperature, and hormonal signals, including auxin, gibberellic acid and brassinosteroid, both transcriptionally and post-translationally. Moreover, recent studies have shown that the circadian clock and metabolic status regulate endogenous PIF4 level. The PIF4 transcription factor cooperatively regulates the target genes involved in cell elongation with hormone-regulated transcription factors. Therefore, PIF4 is a key integrator of multiple signaling pathways, which optimizes growth in the environment. This review will discuss our current understanding of the PIF4-mediated signaling networks that control plant growth.
authors.affiliation: Forest Biotechnology Division, National Institute of Forest Science, Suwon 16631, Korea.
authors.forename: Hyunmo
authors.initials: H
authors.lastname: Choi
authors.affiliation: Department of Bioenergy Science and Technology, Chonnam National University, Gwangju 61186, Korea.
authors.forename: Eunkyoo
authors.initials: E
authors.lastname: Oh
mesh_terms: D017360:Arabidopsis / Q000502:physiology*; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism*; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics / Q000378:metabolism*; D048708:Cell Growth Processes; D057906:Circadian Clocks; D004781:Environmental Exposure / Q000009:adverse effects; D018506:Gene Expression Regulation, Plant; D053263:Gene Regulatory Networks; D063245:Plant Development; D010937:Plant Growth Regulators / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D029681:Arabidopsis Proteins; D051792:Basic Helix-Loop-Helix Proteins; D010937:Plant Growth Regulators; C459466:PIF4 protein, Arabidopsis
keywords: PIF4; brassinosteroid; high temperature; light; signaling integration