title: Potential Roles of Adropin in Central Nervous System: Review of Current Literature.
abstract: Adropin is a 4.9 kDa peptide that is important for maintenance of metabolic and non-metabolic homeostasis. It regulates glucose and fatty acid metabolism and is involved in endothelial cell function and endothelial nitric oxide (NO) synthase bioactivity as well as physical activity and motor coordination. Adropin is expressed in many tissues and organs including central nervous system (CNS). This peptide plays a crucial role in the development of various CNS disorders such as stroke, schizophrenia, bipolar disorder as well as Alzheimer's, Parkinson's, and Huntington's diseases. In this comprehensive review, the potential roles of adropin in cellular signaling pathways that lead to pathogenesis and/or treatment of CNS disorders will be discussed.
authors.affiliation: Department of Neurosurgery, Tehran University of Medical Sciences Tehran, Iran.
authors.forename: Shima
authors.initials: S
authors.lastname: Shahjouei
authors.affiliation: Department of Neurology, University of Tennessee Health Science Center Memphis, TN, USA.
authors.forename: Saeed
authors.initials: S
authors.lastname: Ansari
authors.affiliation: Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center Memphis, TN, USA.
authors.forename: Tayebeh
authors.initials: T
authors.lastname: Pourmotabbed
authors.affiliation: Department of Neurology, University of Tennessee Health Science CenterMemphis, TN, USA; Biocomplexity Institute, Virginia Polytechnic Institute and State UniversityBlacksburg, VA, USA.
authors.forename: Ramin
authors.initials: R
authors.lastname: Zand
keywords: adropin; biomarker; cellular signaling pathways; neurodegenerative disease; neuroprotection; predictor; therapeutic