title: [Biological effects of arsenic and diseases: The mechanisms involved in arsenic-induced carcinogenesis].
abstract: Chronic arsenic exposure is associated with many diseases, including cancers. Our study using in vivo assay in gpt-delta transgenic mice showed that arsenic particularly induces G : C to T : A transversions, a mutation type induced through oxidative-stress-induced 8-OHdG formation. Gestational arsenic exposure of C3H mice was reported to increase hepatic tumor incidence. We showed that gestational arsenic exposure increased hepatic tumors having activated oncogene Ha-ras by C to A mutation. We also showed that DNA methylation status of Fosb region is implicated in tumor augmentation by gestational arsenic exposure. We further showed that long-term arsenic exposure induces premature senescence. Recent studies reported that senescence is involved in not only tumor suppression, but also tumorgenesis. All these effects of arsenic might be involved in arsenic-induced carcinogenesis.
authors.forename: Takehiro
authors.initials: T
authors.lastname: Suzuki
authors.forename: Shota
authors.initials: S
authors.lastname: Takumi
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Okamura
authors.forename: Keiko
authors.initials: K
authors.lastname: Nohara
mesh_terms: D000818:Animals; D001151:Arsenic / Q000633:toxicity*; D002273:Carcinogens / Q000633:toxicity*; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced*; D016922:Cellular Senescence; D004249:DNA Damage; D044127:Epigenesis, Genetic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009154:Mutation
chemical_list: D002273:Carcinogens; D001151:Arsenic