title: Designing a robust backstepping controller for rehabilitation in Parkinson's disease: a simulation study.
abstract: In this study, a model of basal ganglia (BG) is applied to develop a deep brain stimulation controller to reduce Parkinson's tremor. Conventionally, one area in BG is stimulated, with no feedback, to control Parkinson's tremor. In this study, a new architecture is proposed to develop feedback controller as well as to stimulate two areas of BG simultaneously. To this end, two controllers are designed and implemented in globus pallidus internal (GPi) and subthalamic nucleus (STN) in the brain. A proportional controller and a backstepping controller are designed and implemented in GPi and STN, respectively. The proposed controllers deliver suitable stimulatory control signals to GPi and STN based on hand tremor amplitude (as the feedback). When tremor reduces, these controllers decrease the stimulatory energy intensity proportionally. Therefore, additional stimulatory signal is not delivered to the brain. Subsequently, the side effects from the excessive stimulation intensity become much less. Comparing with one area stimulation, the results show that stimulating two areas of BG results in reduction of the level of the stimulation intensity. It is observed that these two controllers are both robust in terms of changing the system parameters.
authors.affiliation: Department of Applied Mathematics, Yazd University, Yazd, Iran. k_rouhollahi@stu.yazd.ac.ir.
authors.forename: Korosh
authors.initials: K
authors.lastname: Rouhollahi
authors.affiliation: Department of Biomedical Engineering, University of Isfahan, Iran.
authors.forename: Mehran
authors.initials: M
authors.lastname: Emadi Andani
authors.affiliation: Department of Applied Mathematics, Yazd University, Yazd, Iran.
authors.forename: Seyed Mahdi
authors.initials: SM
authors.lastname: Karbassi
authors.affiliation: Department of Electrical and Computer Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran.
authors.forename: Iman
authors.initials: I
authors.lastname: Izadi
mesh_terms: D001479:Basal Ganglia / Q000502:physiology*; D046690:Deep Brain Stimulation / Q000379:methods*; D006801:Humans; D008962:Models, Theoretical; D010300:Parkinson Disease / Q000534:rehabilitation*; D020531:Subthalamic Nucleus