title: Amides and neolignans from the aerial parts of Piper bonii.
abstract: Six amides, piperbonamides A-F, three neolignans piperbonins A-C, and 11 known compounds were isolated from the aerial parts of Piper bonii (Piperaceae). The structures of piperbonamides A-F and piperbonins A-C were elucidated based on the analysis of 1D and 2D NMR and MS data. Piperbonin A, (+)-trans-acuminatin, (+)-cis-acuminatin, (+)-kadsurenone, and pipernonaline showed weak activity against platelet aggregation with IC50 values of 118.2, 108.5, 90.02, 107.3, and 116.3 μM, respectively, as compared with the positive control, tirofiban, with an IC50 value of 5.24 μM. Piperbonamides A-F were inactive against five tumor cell lines at concentrations up to 40 μM.
authors.affiliation: Key Laboratory of Economic Plants and Biotechnology, Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
authors.forename: Duo-Duo
authors.initials: DD
authors.lastname: Ding
authors.affiliation: Key Laboratory of Economic Plants and Biotechnology, Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
authors.forename: Yue-Hu
authors.initials: YH
authors.lastname: Wang
authors.affiliation: School of Life Science & Technology, China Pharmaceutical University, Nanjing 210009, People's Republic of China.
authors.forename: Ya-Hui
authors.initials: YH
authors.lastname: Chen
authors.affiliation: Key Laboratory of Economic Plants and Biotechnology, Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
authors.forename: Ren-Qiang
authors.initials: RQ
authors.lastname: Mei
authors.affiliation: Key Laboratory of Economic Plants and Biotechnology, Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.affiliation: Key Laboratory of Economic Plants and Biotechnology, Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
authors.forename: Ji-Feng
authors.initials: JF
authors.lastname: Luo
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Key Laboratory of Economic Plants and Biotechnology, Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China; College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, People's Republic of China. Electronic address: long@mail.kib.ac.cn.
authors.forename: Chun-Lin
authors.initials: CL
authors.lastname: Long
authors.affiliation: School of Life Science & Technology, China Pharmaceutical University, Nanjing 210009, People's Republic of China. Electronic address: yikong668@163.com.
authors.forename: Yi
authors.initials: Y
authors.lastname: Kong
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification; D000577:Amides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification; D006801:Humans; D020128:Inhibitory Concentration 50; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D031701:Piper / Q000737:chemistry*; D010880:Piperidines / Q000737:chemistry / Q000302:isolation & purification; D035261:Plant Components, Aerial / Q000737:chemistry*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D000077466:Tirofiban; D014443:Tyrosine / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D000577:Amides; D001572:Benzofurans; D005419:Flavonoids; D006027:Glycosides; D017705:Lignans; D010880:Piperidines; D010975:Platelet Aggregation Inhibitors; C000614260:piperbonin A; C000614261:piperbonin B; C000614262:piperbonin C; C419151:pipernonaline; C077860:acuminatin; D014443:Tyrosine; C044540:kadsurenone; D000077466:Tirofiban
keywords: Amides; Antiplatelet; Neolignans; Piper bonii; Piperaceae