title: Concurrence of chromosome 6 chromothripsis and glioblastoma metastasis.
abstract: The authors report an unusual case of a widely metastatic glioblastoma. DNA copy number microarray profile of the resected specimen revealed complex rearrangements found throughout chromosome 6, a phenomenon known as chromothripsis. Such chromothripsis pattern was not observed in 50 nonmetastatic glioblastoma specimens analyzed. Analysis of the 1000+ gliomas profiled by The Cancer Genome Atlas (TCGA) data set revealed one case of chromosome 6 chromothripsis resembling the case described here. This TCGA patient died within 6 months of undergoing tumor resection. Implications of these findings are reviewed in the context of the current literature.
authors.affiliation: Departments of 1 Neurosurgery and.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Rennert
authors.affiliation: Departments of 1 Neurosurgery and.
authors.forename: Reid R
authors.initials: RR
authors.lastname: Hoshide
authors.affiliation: Departments of 1 Neurosurgery and.
authors.forename: Jason W
authors.initials: JW
authors.lastname: Signorelli
authors.affiliation: Pathology, University of California, San Diego, California; and.
authors.forename: Deirdre
authors.initials: D
authors.lastname: Amaro
authors.affiliation: Departments of 1 Neurosurgery and.
authors.forename: Jayson A
authors.initials: JA
authors.lastname: Sack
authors.affiliation: Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York.
authors.forename: Cameron W
authors.initials: CW
authors.lastname: Brennan
authors.affiliation: Departments of 1 Neurosurgery and.
authors.forename: Clark C
authors.initials: CC
authors.lastname: Chen
mesh_terms: D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology*; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D000072837:Chromothripsis; D005909:Glioblastoma / Q000000981:diagnostic imaging / Q000235:genetics* / Q000556:secondary*; D006801:Humans; D008297:Male; D055815:Young Adult
keywords: TCGA = The Cancer Genome Atlas; chromothripsis; glioblastoma; metastasis; oncology