title: MICROBIOLOGICAL ANALYSIS OF BILE IN PATIENTS WITH BENIGN AND MALIGNANT BILIOPANCREATIC DISEASES AND ITS CONSEQUENCES.
abstract: BACKGROUND
  Bactibilia has several consequences to human health.
  
  
  OBJECTIVE
  Assessing the bile microbiology of patients with biliopancreatic diseases in order to identify bacteria and their possible infectious complications.
  
  
  METHODS
  Retrospective study of 30 bile culture samples from patients with benign and malignant biliopancreatic diseases. The samples were assessed to set the bile microbiological flora and to search for its possible link with comorbidity, carcinogenesis and postoperative infectious complications.
  
  
  RESULTS
  Thirty bile samples from patients at mean age ≈57.7 years, mostly female (n=18), were assessed. Bactibilia was found in 12 cases, mostly in patients with benign diseases (n=8), older than 50 years (n=23) and female (n=10). Adenocarcinoma of the duodenal papilla (n=9) and cholelithiasis (n=8) were the most common diseases. Escherichia coli (n=5) and Klebsiella sp (n=3) were predominantly found in patients with benign diseases; and Klebsiella sp (n=2) and Streptococcus sp (n=2) were prevalent in cancer patients. There were postoperative infectious complications in seven cases, five of them in bactibilia-associated patients (P=0.084).
  
  
  CONCLUSIONS
  Bactibilia was found in 12 samples and Escherichia coli and Klebsiella sp were most often identified in patients with benign diseases, as well as Streptococcus sp and Klebsiella sp in cancer patients. There was a trend of higher postoperative infectious complication incidence in patients with bactibilia.
authors.affiliation: Departamento de Medicina Integrada, Faculdade de Medicina, Universidade Federal do Rio Grande do Norte, RN, Brasil.
authors.forename: José Roberto
authors.initials: JR
authors.lastname: Alves
authors.affiliation: Faculdade de Medicina, Universidade Federal do Rio Grande do Norte, RN, Brasil.
authors.forename: Rodrigo do Carmo
authors.initials: Rdo C
authors.lastname: Silva
authors.affiliation: Faculdade de Medicina, Universidade Federal do Rio Grande do Norte, RN, Brasil.
authors.forename: Sâmea Costa Pinheiro
authors.initials: SC
authors.lastname: Guerra
authors.affiliation: Faculdade de Medicina, Universidade Federal do Rio Grande do Norte, RN, Brasil.
authors.forename: Tiago Tavares de
authors.initials: TT
authors.lastname: Freitas
authors.affiliation: Saúde Coletiva, Universidade Federal do Rio Grande do Norte, RN, Brasil.
authors.forename: Dyego Leandro Bezerra de
authors.initials: DL
authors.lastname: Souza
authors.affiliation: Departamento de Medicina Integrada, Faculdade de Medicina, Universidade Federal do Rio Grande do Norte, RN, Brasil.
authors.forename: Enio Campos
authors.initials: EC
authors.lastname: Amico
mesh_terms: D000230:Adenocarcinoma / Q000382:microbiology* / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014670:Ampulla of Vater / Q000382:microbiology* / Q000601:surgery; D001646:Bile / Q000382:microbiology*; D042883:Choledocholithiasis / Q000382:microbiology* / Q000601:surgery; D003138:Common Bile Duct Neoplasms / Q000382:microbiology* / Q000601:surgery; D004926:Escherichia coli / Q000302:isolation & purification; D005260:Female; D005334:Fever / Q000601:surgery; D006801:Humans; D007709:Klebsiella / Q000302:isolation & purification; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012189:Retrospective Studies; D013291:Streptococcus / Q000302:isolation & purification; D055815:Young Adult