title: Magnetic nanomaterials and sensors for biological detection.
abstract: It is becoming progressively more understandable that sensitivity and versatility of magnetic biosensors provides unique platform for high performance diagnostics in clinical settings. Confluence of information suggested that magnetic biosensors required well-tailored magnetic particles as probes for detection that generate large and specific biological signal with minimum possible nonspecific binding. However, there are visible knowledge gaps in our understanding of the strategies to overcome existing challenges related to even smaller size of intracellular targets and lower signal-to-noise ratio than that in whole-cell studies, therefore tool designing and development for intracellular measurement and manipulation is problematic. In this review we describe magnetic nanoparticles, synthesis and sensing principles of magnetic nanoparticles as well as surface functionalization and modification and finally magnetic nanoparticles for medical diagnostics. This review gathers important and up-to-date information and may help to develop the method of obtaining magnetic materials especially for medical application.
authors.affiliation: Institute of Inorganic Chemistry and Technology, Cracow University of Technology, Cracow, Poland. Electronic address: asobczak@chemia.pk.edu.pl.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Sobczak-Kupiec
authors.affiliation: Department of Chemistry, Marine Bio process Research Center, Pukyong National University, Busan, South Korea. Electronic address: venkatjchem@pknu.ac.kr.
authors.forename: Jayachandran
authors.initials: J
authors.lastname: Venkatesan
authors.affiliation: Department of Chemical Engineering Technology, College of Technological Studies, The Public Authority for Applied Education and Training (PAAET), Sabah Alsalem, Kuwait. Electronic address: aa.alanezi@paaet.edu.kw.
authors.forename: Adnan
authors.initials: A
authors.lastname: Alhathal AlAnezi
authors.affiliation: Institute of Inorganic Chemistry and Technology, Cracow University of Technology, Cracow, Poland.
authors.forename: Dorota
authors.initials: D
authors.lastname: Walczyk
authors.affiliation: Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan. Electronic address: ammadfarooqi@rlmclahore.com.
authors.forename: Ammad
authors.initials: A
authors.lastname: Farooqi
authors.affiliation: Institute of Inorganic Chemistry and Technology, Cracow University of Technology, Cracow, Poland.
authors.forename: Dagmara
authors.initials: D
authors.lastname: Malina
authors.affiliation: Department of Chemistry, Faculty of Science, Central Tehran Branch, Islamic Azad University, Tehran, Iran. Electronic address: hosseini_sh44@yahoo.com.
authors.forename: Seyed Hossein
authors.initials: SH
authors.lastname: Hosseini
authors.affiliation: Cracow University of Technology, Department of Polymer Chemistry and Technology, Cracow, Poland. Electronic address: btyliszczak@chemia.com.
authors.forename: Bozena
authors.initials: B
authors.lastname: Tyliszczak
mesh_terms: D015374:Biosensing Techniques; D008280:Magnetics; D053758:Nanoparticles; D049329:Nanostructures; D059629:Signal-To-Noise Ratio
keywords: Magnetic nanoparticles; Magnetic nanoparticles for medical diagnostics; Sensing principles of magnetic nanoparticles; Surface functionalization and modification; Synthesis