title: Antifungal Monoterpene Derivatives from the Plant Endophytic Fungus Pestalotiopsis foedan.
abstract: A new monoterpene lactone, (1R,4R,5R,8S)-8-hydroxy-4,8-dimethyl-2-oxabicyclo[3.3.1]nonan-3-one (1), along with one related known compound, (2R)-2-[(1R)-4-methylcyclohex-3-en-1-yl]propanoic acid (2), were isolated from the liquid culture of the plant endophytic fungus Pestalotiopsis foedan obtained from the branch of Bruguiera sexangula. The structure and absolute configuration of 1 were determined on the basis of extensive analysis of NMR spectra combined with computational methods via calculation of the optical rotation (OR) and13C-NMR. Both compounds exhibited strong antifungal activities against Botrytis cinerea and Phytophthora nicotianae with MIC values of 3.1 and 6.3 μg/ml, respectively, which are comparable to those of the known antifungal drug ketoconazole. Compound 2 also showed modest antifungal activity against Candida albicans with a MIC value of 50 μg/ml.
authors.affiliation: Innovative Drug Research Centre, Chongqing University (Huxi Campus), Chongqing, 401331, P. R. China.
authors.forename: Dan
authors.initials: D
authors.lastname: Xu
authors.affiliation: College of Pharmaceutical Science, Hebei University, Baoding, 071002, P. R. China.
authors.forename: Bing-Yang
authors.initials: BY
authors.lastname: Zhang
authors.affiliation: Innovative Drug Research Centre, Chongqing University (Huxi Campus), Chongqing, 401331, P. R. China. yxl19830915@163.com.
authors.forename: Xiao-Long
authors.initials: XL
authors.lastname: Yang
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D020171:Botrytis / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D060026:Endophytes / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010838:Phytophthora / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013098:Xylariales / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D039821:Monoterpenes
keywords: 
  Bruguiera sexangula
  ; 
  Pestalotiopsis foedan
  ; Antifungal activities; Endophytic fungi; Monoterpene