title: Mind-body therapy via videoconferencing in patients with neurofibromatosis: An RCT.
abstract: OBJECTIVE
  To test, within a single-blind randomized controlled trial, the feasibility, acceptability, efficacy, and durability of a mind-body program (the Relaxation Response Resiliency Program for neurofibromatosis [3RP-NF]) vs an attention placebo control (Health Enhancement Program for NF [HEP-NF]), both delivered via group videoconferencing.
  
  
  METHODS
  Sixty-three patients completed baseline assessments and were randomized. Primary outcomes were physical health and psychological quality of life (QoL), measured by the WHOQOL-BREF (World Health Organization QoL abbreviated instrument). Secondary outcomes were social relations and environment QoL, depression, anxiety, pain intensity, and pain interference.
  
  
  RESULTS
  Sixty-three participants completed the intervention (100%) and 52 the 6-month follow-up (82.5%). Acceptability was 4.1 (5-point scale). Patients in the 3RP-NF showed greater improvement in physical health QoL (7.69; 95% confidence interval [CI]: 0.29-15.10; p = 0.040), psychological QoL (5.57; 95% CI: 0.17-11.34; p = 0.056), social relations QoL (10.95; 95% CI: 1.57-20.31; p = 0.021), environment QoL (8.02; 95% CI: 2.57-13.48; p = 0.005), and anxiety (-2.32; 95% CI: -3.96 to 0.69; p = 0.006) compared to those in HEP-NF, and gains were maintained at follow-up. Patients in the 3RP-NF did not improve more than those in HEP-NF on depression, with both groups showing improvement. Patients in the 3RP-NF with baseline pain ≥5 of 10 showed improvement in pain intensity from baseline to posttest (1.30; 95% CI: -2.26 to -0.34; p = 0.009) with effects maintained at follow-up; this improvement was not greater than that in HEP-NF. There were more treatment responders in the 3RP-NF group (p < 0.05).
  
  
  CONCLUSIONS
  The 3RP-NF delivered via videoconferencing was highly feasible and accepted by patients, and resulted in sustained improvement in QoL.
  
  
  METHODS
  This study provides Class II evidence that for patients with NF, a mind-body program is superior to an attention placebo control in improving QoL.
authors.affiliation: From the Behavioral Medicine Service (A.-M.V.), Benson-Henry Institute for Mind Body Medicine (E.R., E.R.P.), and Department of Neurology and Cancer Center (V.L.M., S.R.P.), Massachusetts General Hospital, Boston; Biostatistics Center (E.A.M.), Massachusetts General Hospital and Harvard Medical School, Boston, MA. avranceanu@partners.org.
authors.forename: Ana-Maria
authors.initials: AM
authors.lastname: Vranceanu
authors.affiliation: From the Behavioral Medicine Service (A.-M.V.), Benson-Henry Institute for Mind Body Medicine (E.R., E.R.P.), and Department of Neurology and Cancer Center (V.L.M., S.R.P.), Massachusetts General Hospital, Boston; Biostatistics Center (E.A.M.), Massachusetts General Hospital and Harvard Medical School, Boston, MA.
authors.forename: Eric
authors.initials: E
authors.lastname: Riklin
authors.affiliation: From the Behavioral Medicine Service (A.-M.V.), Benson-Henry Institute for Mind Body Medicine (E.R., E.R.P.), and Department of Neurology and Cancer Center (V.L.M., S.R.P.), Massachusetts General Hospital, Boston; Biostatistics Center (E.A.M.), Massachusetts General Hospital and Harvard Medical School, Boston, MA.
authors.forename: Vanessa L
authors.initials: VL
authors.lastname: Merker
authors.affiliation: From the Behavioral Medicine Service (A.-M.V.), Benson-Henry Institute for Mind Body Medicine (E.R., E.R.P.), and Department of Neurology and Cancer Center (V.L.M., S.R.P.), Massachusetts General Hospital, Boston; Biostatistics Center (E.A.M.), Massachusetts General Hospital and Harvard Medical School, Boston, MA.
authors.forename: Eric A
authors.initials: EA
authors.lastname: Macklin
authors.affiliation: From the Behavioral Medicine Service (A.-M.V.), Benson-Henry Institute for Mind Body Medicine (E.R., E.R.P.), and Department of Neurology and Cancer Center (V.L.M., S.R.P.), Massachusetts General Hospital, Boston; Biostatistics Center (E.A.M.), Massachusetts General Hospital and Harvard Medical School, Boston, MA.
authors.forename: Elyse R
authors.initials: ER
authors.lastname: Park
authors.affiliation: From the Behavioral Medicine Service (A.-M.V.), Benson-Henry Institute for Mind Body Medicine (E.R., E.R.P.), and Department of Neurology and Cancer Center (V.L.M., S.R.P.), Massachusetts General Hospital, Boston; Biostatistics Center (E.A.M.), Massachusetts General Hospital and Harvard Medical School, Boston, MA.
authors.forename: Scott R
authors.initials: SR
authors.lastname: Plotkin
mesh_terms: D000328:Adult; D001007:Anxiety / Q000209:etiology / Q000628:therapy*; D003863:Depression / Q000209:etiology / Q000628:therapy*; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D026441:Mind-Body Therapies / Q000379:methods*; D017253:Neurofibromatoses / Q000150:complications / Q000628:therapy*; D017063:Outcome Assessment, Health Care; D010342:Patient Acceptance of Health Care; D011615:Psychotherapy, Group / Q000379:methods*; D011788:Quality of Life; D016037:Single-Blind Method; D017216:Telemedicine / Q000379:methods*; D049269:Videoconferencing