title: Diseases of the circulatory system among adult people diagnosed with infantile autism as children: A longitudinal case control study.
abstract: BACKGROUND
  Research dealing with adult people with autism spectrum disorders (ASD) noticeably lags behind studies of children and young individuals with ASD.
  
  
  OBJECTIVE
  The objective of this study was to compare the prevalence and types of diseases of the circulatory system in a clinical sample of 118 adult people diagnosed with infantile autism (IA) as children with 336 sex and age matched controls from the general population.
  
  
  METHODS
  All participants were screened through the nationwide Danish National Hospital Register. The average observation time of both groups was 37.2 years, and mean age at follow-up was 49.6 years.
  
  
  RESULTS
  Of the 118 people with IA, 11 (9.3%) were registered with at least one disease of the circulatory system against 54 (16.1%) in the comparison group (p=0.09; OR=0.54; 95% CI 0.3-1.2). Ischemic heart diseases occurred significantly more frequently among people in the comparison group (p=0.02).
  
  
  CONCLUSIONS
  It is argued that diseases of the circulatory system may be underdiagnosed in people with IA because of the difficulties they face with respect to identifying and communicating symptoms of ill health. Bearing in mind that cardiovascular disease is the primary cause of death in most developed countries, it is suggested that to prevent disease and manage health conditions, health monitoring is essential in adult people with IA.
authors.affiliation: Centre for Child and Adolescent Psychiatry, Bispebjerg University Hospital, DK 2400 Copenhagen, Denmark. Electronic address: Svend.Erik.Mouridsen@regionh.dk.
authors.forename: Svend Erik
authors.initials: SE
authors.lastname: Mouridsen
authors.affiliation: Kong Valdemars Vej 75, Roskilde, Denmark.
authors.forename: Bente
authors.initials: B
authors.lastname: Rich
authors.affiliation: Centre for Child and Adolescent Psychiatry, Glostrup University Hospital, Glostrup, Denmark.
authors.forename: Torben
authors.initials: T
authors.lastname: Isager
mesh_terms: D000328:Adult; D000368:Aged; D001321:Autistic Disorder / Q000453:epidemiology*; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D016022:Case-Control Studies; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000453:epidemiology; D015995:Prevalence; D012042:Registries
keywords: Adult; Diseases of the circulatory system; Infantile autism; Ischemic heart disease