title: Sex disparity in the association between hypertriglyceridemic waist phenotype and arterial stiffness in Chinese healthy subjects.
abstract: OBJECTIVE
  To investigate the association between hypertriglyceridemic waist (HTGW) phenotype and arterial stiffness in a Chinese population without hypertension, diabetes and cardiovascular diseases.
  
  
  METHODS
  A total number of 3028 subjects aged 40 years and over were enrolled in this cross-sectional study. All participants provided a clinical history and underwent a physical examination. Brachial-ankle pulse wave velocity (baPWV) was used to evaluate arterial stiffness. HTGW phenotype was defined as the simultaneous presence of waist circumference ≥90/80 cm and triglycerides ≥2.0/1.5 mmol/L in men/women.
  
  
  RESULTS
  The prevalence of HTGW phenotype was 7.5% among healthy participants in China (Beijing), 7.4% in men and 7.5% in women. Women with HTGW phenotype had a higher level of baPWV compared with normal WC and normal triglyceride (NWNT) group (P < 0.05), but no significant difference was observed in men (P > 0.05). Multiple logistic regression analysis showed HTGW phenotype was significantly associated with baPWV after controlling for multiple factors in women. However, no significant relationship was observed in men.
  
  
  CONCLUSIONS
  The present study supports that HTGW phenotype is associated with increased arterial stiffness in women but not in men.
authors.affiliation: a Department of Endocrinology , Chinese PLA General Hospital , Beijing , China.
authors.forename: Kang
authors.initials: K
authors.lastname: Chen
authors.affiliation: b Department of Endocrinology, Beijing Shijitan Hospital , Capital Medical University , Beijing , China.
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.affiliation: b Department of Endocrinology, Beijing Shijitan Hospital , Capital Medical University , Beijing , China.
authors.forename: Yi-Jun
authors.initials: YJ
authors.lastname: Li
authors.affiliation: a Department of Endocrinology , Chinese PLA General Hospital , Beijing , China.
authors.forename: Ting
authors.initials: T
authors.lastname: Li
authors.affiliation: a Department of Endocrinology , Chinese PLA General Hospital , Beijing , China.
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Mu
mesh_terms: D000328:Adult; D000367:Age Factors; D055109:Ankle Brachial Index; D050197:Atherosclerosis / Q000453:epidemiology*; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D064250:Hypertriglyceridemic Waist / Q000453:epidemiology*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D015995:Prevalence; D012737:Sex Factors; D012959:Socioeconomic Factors; D014280:Triglycerides / Q000097:blood; D059289:Vascular Stiffness / Q000502:physiology*; D055105:Waist Circumference
chemical_list: D014280:Triglycerides
keywords: Hypertriglyceridemic waist; abdominal obesity; arterial stiffness; brachial-ankle pulse wave velocity; cardiometabolic risk