title: [Using a multicomponent functional food in IBS patients with constipation a comparative controlled study].
abstract: Irritable bowel syndrome (IBS) is highly prevalent functional gastrointestinal disorder associated with decrease in quality of life and a high social cost. Diet is one of several therapeutic options in IBS treatment; therefore the development and clinical evaluation of innovative functional food for IBS patients are actual. Instant drink containing 4 g inulin, 4 mg menthol and 2 mg of pyridoxine (in daily dose) has been evaluated. 49 patients 18-68 (41.5±16.5) years old fulfilling the Rome III criteria for IBS-C were randomly assigned into two groups: one received standard diet plus two drinks per day for 2 weeks and control group received standard diet. Response to therapy was recorded daily using Likert scale of abdominal pain, bloating and feeling of incomplete bowel emptying, frequency of bowel movement, Bristol stool scale, and quality of life was assessed by IBSQoL questionnaire before and after the treatment. The consumption of the drink with inulin and menthol contributed to a significant positive effect on the stool parameters (from 0.91±0.73 to 1.12±0.45 bowel movements per day in stool frequency, p=0.05, from 2.68±1.63 to 3.43±1.27 index Bristol scale, p=0.05), reduced the severity of abdominal pain (from 1.78±0.58 to 1.47?0.61 Likert scale points, p=0.05), bloating (from 2.22±0.83 to 1.53±0.71 points ofLikertscale,p= 0.01) and a sense of incomplete bowelemptying (from 2.22 ± 0.88 to 1.61± 0.81 points of Likert scale, p=0.001), as well as increased the quality of life (from 75.3± 12.0 to 83.3±6.7%, p=0.05), but a significant part of patients (10 of 25) complained the appearance of heartburn after the start of the treatment. In conclusion, the consumption of the functional drink containing inulin, menthol and pyridoxine is associated with improve in stool parameters, abdominal pain, Bristol scale index and increase in quality of life in patients with IBS-C, but produce noticeable heartburn. Changes in functional drink composition are needed to reduce adverse effects.
authors.forename: V I
authors.initials: VI
authors.lastname: Pilipenko
authors.forename: D A
authors.initials: DA
authors.lastname: Teplyuk
authors.forename: A K
authors.initials: AK
authors.lastname: Shakhovskaya
authors.forename: V A
authors.initials: VA
authors.lastname: Isakov
authors.forename: V M
authors.initials: VM
authors.lastname: Vorobyova
authors.forename: I S
authors.initials: IS
authors.lastname: Vorobyova
authors.forename: V A
authors.initials: VA
authors.lastname: Sarkisyan
authors.forename: A A
authors.initials: AA
authors.lastname: Kochetkova
authors.forename: G A
authors.initials: GA
authors.lastname: Mikheeva
authors.forename: A V
authors.initials: AV
authors.lastname: Yudina
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001628:Beverages / Q000032:analysis; D003113:Colonoscopy; D003248:Constipation / Q000150:complications / Q000178:diet therapy* / Q000503:physiopathology; D005260:Female; D055951:Functional Food; D005769:Gastrointestinal Motility / Q000502:physiology; D006801:Humans; D007444:Inulin / Q000032:analysis; D043183:Irritable Bowel Syndrome / Q000150:complications / Q000178:diet therapy* / Q000503:physiopathology; D008297:Male; D008610:Menthol / Q000032:analysis; D018977:Micronutrients / Q000032:analysis; D008875:Middle Aged; D009751:Nutritional Requirements; D009753:Nutritive Value; D011134:Polysaccharides / Q000032:analysis; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D018977:Micronutrients; D011134:Polysaccharides; D008610:Menthol; C008315:maltodextrin; D007444:Inulin