title: Effect of Bayesian-penalized likelihood reconstruction on [13N]-NH3 rest perfusion quantification.
abstract: OBJECTIVES: Myocardial blood flow (MBF) imaging is used in patients with suspected cardiac sarcoidosis, and also in stress/rest studies. The accuracy of MBF is dependent on imaging parameters such as new reconstruction methodologies. In this work, we aim to assess the impact of a novel PET reconstruction algorithm (Bayesian-penalized likelihood-BPL) on the values determined from the calculation of [13N]-NH3 MBF values.
  
  
  
  Data from 21 patients undergoing rest MBF evaluation [13N]-NH3 as part of sarcoidosis imaging were retrospectively analyzed. Each scan was reconstructed with a range of BPL coefficients (1-500), and standard clinical FBP and OSEM reconstructions. MBF values were calculated via an automated software routine for all datasets.
  
  
  
  Reconstruction of [13N]-NH3 dynamic data using the BPL, OSEM, or FBP reconstruction showed no quantitative differences for the calculation of territorial or global MBF (P = .97). Image noise was lower using OSEM or BPL reconstructions than FBP and noise from BPL reached levels seen in OSEM images between B = 300 and B = 400. Intrasubject differences between all reconstructions over all patients in respect of all cardiac territories showed a maximum coefficient of variation of 9.74%.
  
  
  
  Quantitation of MBF via kinetic modeling of cardiac rest MBF by [13N]-NH3 is minimally affected by the use of a BPL reconstruction technique, with BPL images presenting with less noise.
authors.affiliation: PET Imaging Centre, Division of Imaging Sciences and Biomedical Engineering, King's College London, King's Health Partners, St. Thomas' Hospital, 1st Floor, Lambeth Wing, London, SE1 7EH, United Kingdom. jim.odoherty@kcl.ac.uk.
authors.forename: Jim
authors.initials: J
authors.lastname: O' Doherty
authors.affiliation: Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7DQ, United Kingdom.|Radiation Physics and Protection, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 7LE, United Kingdom.
authors.forename: Daniel R
authors.initials: DR
authors.lastname: McGowan
authors.affiliation: PET Imaging Centre, Division of Imaging Sciences and Biomedical Engineering, King's College London, King's Health Partners, St. Thomas' Hospital, 1st Floor, Lambeth Wing, London, SE1 7EH, United Kingdom.
authors.forename: Carla
authors.initials: C
authors.lastname: Abreu
authors.affiliation: PET Imaging Centre, Division of Imaging Sciences and Biomedical Engineering, King's College London, King's Health Partners, St. Thomas' Hospital, 1st Floor, Lambeth Wing, London, SE1 7EH, United Kingdom.
authors.forename: Sally
authors.initials: S
authors.lastname: Barrington
mesh_terms: D000465:Algorithms; D001499:Bayes Theorem; D001783:Blood Flow Velocity; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D003326:Coronary Circulation; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D016013:Likelihood Functions; D008297:Male; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D009590:Nitrogen Radioisotopes; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D009590:Nitrogen Radioisotopes; D019275:Radiopharmaceuticals
keywords: N-13 ammonia; PET; physics of imaging