title: Monocyte Chemoattractant Protein-1 and Large Artery Structure and Function in Young Individuals: The African-PREDICT Study.
abstract: To better understand hypertension development, the authors determined whether monocyte chemoattractant protein-1 (MCP-1) is associated with arterial stiffness (pulse wave velocity [PWV]) and carotid intima-media wall thickness (cIMT) in a young apparently healthy black and white population (N=403, aged 20-30 years). Carotid-femoral PWV, central systolic blood pressure, and cIMT were measured, and MCP-1, reactive oxygen species, inflammatory markers (interleukin 6, tumor necrosis factor α), and endothelial activation (intercellular adhesion molecule, vascular cell adhesion molecule) were determined from blood samples. Although carotid-femoral PWV and cIMT were similar between blacks and whites, black men and women showed higher central systolic blood pressure, MCP-1, and reactive oxygen species than whites (all P<.05). In addition, black women had higher brachial blood pressure and interleukin 6 (all P<.001). A consistent positive association only in black women between cIMT and MCP-1 in multiple regression analyses was found (R²=0.151, β=0.248; P=.021). In this model, cIMT was also independently associated with vascular cell adhesion molecule (β=0.251; P=.022). The authors found elevated central systolic blood pressure and MCP-1 in young blacks, where cIMT was independently associated with MCP-1 in black women.
authors.affiliation: Hypertension in Africa Research Team, North-West University, Potchefstroom, South Africa.
authors.forename: Johanna I
authors.initials: JI
authors.lastname: Kriel
authors.affiliation: Hypertension in Africa Research Team, North-West University, Potchefstroom, South Africa.
authors.forename: Carla M T
authors.initials: CM
authors.lastname: Fourie
authors.affiliation: Hypertension in Africa Research Team, North-West University, Potchefstroom, South Africa.|MRC Research Unit on Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa.
authors.forename: Aletta E
authors.initials: AE
authors.lastname: Schutte
mesh_terms: D000328:Adult; D001794:Blood Pressure; D002339:Carotid Arteries / Q000378:metabolism / Q000503:physiopathology*; D059168:Carotid Intima-Media Thickness; D018932:Chemokine CCL2 / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000208:ethnology / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D063177:Pulse Wave Analysis; D013019:South Africa / Q000208:ethnology; D059289:Vascular Stiffness; D055815:Young Adult
chemical_list: C111835:CCL2 protein, human; D018932:Chemokine CCL2