title: [Analysis of hemophilia case information of Shandong province].
abstract: OBJECTIVE
  To summarize the general condition, regional distribution, prevalence and clinical characteristics of Shandong province based on hemophilia case registry information.
  
  
  METHODS
  A retrospective study was carried out on 1979 hemophilia patients registered at Shandong Hemophilia Registration Center.
  
  
  RESULTS
  The 1979 cases have included 1704 hemophilia A and 275 hemophilia B patients. Hemophilia A was characterized as severe in 1021 patients (59.9%), moderate in 483 patients (28.4%), and mild in 200 patients (11.7%); while hemophilia B was characterized as severe in 125 patients (45.4%), moderate in 116 patients (42.2%), and mild in 34 patients (12.4%). The median age was 23 years (ranging from 1 month to 81 years), and most were young patients. Joint deformity occurred in 963 patients, and 948 patients had a family history of hemophilia. All counties of Shandong province had patients except for Changdao county and Fushan district of Yantai city. The prevalence of Heze city and Dongying city (3.39/100 000 and 3.05/100 000, respectively) were relatively higher.
  
  
  CONCLUSIONS
  The above data revealed epidemiological and clinical characteristics of Shandong Province. Patient-centered registry system allowed a more detailed and accurate patient information, and promoted the comprehensive care of hemophilia, which also suggested the necessity for the establishment and improvement of the National Hemophilia Registry System.
authors.affiliation: Blood Center of Shandong Province, Jinan, Shandong 250014, China; Shandong University School of Medicine, Jinan, Shandong 250012, China. Email: zhangxs1963@aliyun.com.
authors.forename: Peipei
authors.initials: P
authors.lastname: Kang
authors.forename: Yunhai
authors.initials: Y
authors.lastname: Fang
authors.forename: Jingmin
authors.initials: J
authors.lastname: Qin
authors.forename: Yan
authors.initials: Y
authors.lastname: Cheng
authors.forename: Li
authors.initials: L
authors.lastname: An
authors.forename: Congxiao
authors.initials: C
authors.lastname: Zhang
authors.forename: Xueqin
authors.initials: X
authors.lastname: Zhang
authors.forename: Bin
authors.initials: B
authors.lastname: Teng
authors.forename: Xinsheng
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D006467:Hemophilia A / Q000453:epidemiology*; D006801:Humans; D007223:Infant; D008875:Middle Aged; D015995:Prevalence; D012042:Registries