title: Intrinsic, Functional, and Structural Properties of β-Thymosins and β-Thymosin/WH2 Domains in the Regulation and Coordination of Actin Self-Assembly Dynamics and Cytoskeleton Remodeling.
abstract: β-Thymosins are a family of heat-stable multifunctional polypeptides that are expressed as small proteins of about 5kDa (~45 amino acids) almost exclusively in multicellular animals. They were first isolated from the thymus. As full-length or truncated polypeptides, they appear to stimulate a broad range of extracellular activities in various signaling pathways, including tissue repair and regeneration, inflammation, cell migration, and immune defense. However, their cell surface receptors and structural mechanisms of regulations in these multiple pathways remain still poorly understood. Besides their extracellular activities, they belong to a larger family of small, intrinsically disordered actin-binding domains called WH2/β-thymosin domains that have been identified in more than 1800 multidomain proteins found in different taxonomic domains of life and involved in various actin-based motile processes including cell morphogenesis, motility, adhesions, tissue development, intracellular trafficking, or pathogen infections. This review briefly surveys the main recent findings to understand how these small, intrinsically disordered but functional domains can interact with many unrelated partners and can thus integrate and coordinate various intracellular activities in actin self-assembly dynamics and cell signaling pathways linked to their cytoskeleton remodeling.
authors.affiliation: Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ. Paris-Sud, Université Paris-Saclay, Gif-sur-Yvette, France. Electronic address: louis.renault@i2bc.paris-saclay.fr.
authors.forename: L
authors.initials: L
authors.lastname: Renault
mesh_terms: D000199:Actins / Q000378:metabolism*; D000595:Amino Acid Sequence; D001665:Binding Sites / Q000502:physiology; D002468:Cell Physiological Phenomena; D003599:Cytoskeleton / Q000502:physiology*; D006801:Humans; D064267:Intrinsically Disordered Proteins / Q000737:chemistry / Q000502:physiology; D015394:Molecular Structure; D051304:Profilins / Q000502:physiology; D011485:Protein Binding; D011487:Protein Conformation; D017510:Protein Folding; D011971:Receptors, Immunologic / Q000502:physiology; D012091:Repetitive Sequences, Nucleic Acid; D015398:Signal Transduction; D013947:Thymosin / Q000737:chemistry* / Q000502:physiology*
chemical_list: D000199:Actins; D064267:Intrinsically Disordered Proteins; D051304:Profilins; D011971:Receptors, Immunologic; C034055:thymosin receptor; D013947:Thymosin
keywords: Actin cytoskeleton; Actin-binding proteins; Functional versatility; Fuzzy complex; Intrinsically disordered; Multifunctionality; Structure–function relationship; Thymosin-β4; WH2 domain; β-Thymosin