title: Regulation of the miRNA expression by TEL/AML1, BCR/ABL, MLL/AF4 and TCF3/PBX1 oncoproteins in acute lymphoblastic leukemia (Review).
abstract: MicroRNAs (miRNAs) are a class of small endogenous non-coding RNAs that play important regulatory roles by targeting mRNAs for cleavage or translational repression. miRNAs act in diverse biological processes including development, cell growth, apoptosis, and hematopoiesis. The miRNA expression is associated with specific cytogenetic changes and can also be used to discriminate between the different subtypes of leukemia in acute lymphoblastic leukemia with common translocations, it is shown that the miRNAs have the potential to be used for clinical diagnosis and prognosis. We reviewed the roles of miRNA here with emphasis on their function in human leukemia and the mechanisms of the TEL/AML1, BCR/ABL, MLL/AF4 and TCF3/PBX1 oncoproteins on miRNAs expression in acute lymphoblastic leukemia.
authors.affiliation: Institute of Cellular Physiology, National Autonomous University of Mexico (UNAM), University City, D.F., Mexico.
authors.forename: Jorge
authors.initials: J
authors.lastname: Organista-Nava
authors.affiliation: Institute of Cellular Physiology, National Autonomous University of Mexico (UNAM), University City, D.F., Mexico.
authors.forename: Yazmín
authors.initials: Y
authors.lastname: Gómez-Gómez
authors.affiliation: Laboratory of Molecular Biomedicine, School of Chemical-Biological Sciences, Guerrero State University, Chilpancingo, Guerrero, Mexico.
authors.forename: Berenice
authors.initials: B
authors.lastname: Illades-Aguiar
authors.affiliation: Laboratory of Molecular Biomedicine, School of Chemical-Biological Sciences, Guerrero State University, Chilpancingo, Guerrero, Mexico.
authors.forename: Marco Antonio
authors.initials: MA
authors.lastname: Leyva-Vázquez
mesh_terms: D050676:Core Binding Factor Alpha 2 Subunit / Q000235:genetics*; D016044:Fusion Proteins, bcr-abl / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics*; D015513:Oncogene Proteins / Q000235:genetics*; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D000097764:ETS Translocation Variant 6 Protein
chemical_list: D050676:Core Binding Factor Alpha 2 Subunit; D016044:Fusion Proteins, bcr-abl; D035683:MicroRNAs; D051788:Myeloid-Lymphoid Leukemia Protein; D015513:Oncogene Proteins; D015514:Oncogene Proteins, Fusion; C113855:MLL-AF4 fusion protein, human; C543638:TCF3-PBX1 fusion protein, human; C102421:TEL-AML1 fusion protein; D000097764:ETS Translocation Variant 6 Protein