title: Retrospective analysis of factors influencing oncologic outcome in 590 patients with early-intermediate glottic cancer treated by transoral laser microsurgery.
abstract: The purpose of this study was to identify the factors influencing oncologic outcomes for patients with early-intermediate glottic cancer treated by transoral laser microsurgery (TLM).
  
  
  
  This was a retrospective mono-institutional study. A total of 590 patients with cTis-cT3 glottic cancer underwent TLM with curative intent.
  
  
  
  TLM alone was performed in 538 patients (91.2%) and TLM followed by adjuvant radiotherapy (RT) was done in 52 (8.8%). Five-year recurrence-free survival (RFS) and 10-year overall survival (OS) were 85.3% and 74.7%, respectively. The larynx-preservation ratio was 95.9%. In particular, from our data, we found that occult metastases were rare (1.2%); preventive tracheotomy was not necessary; the local recurrence rate of Tis was similar to that in the T2 and T3 group; and no major or lethal complications were observed.
  
  
  
  Age (>60 vs ≤60), type of cordectomy (≥IV vs ≤III), status of margins, fixed arytenoid, and pathologic T classification, were the variables associated with RFS, OS, and organ-preservation rate. © 2016 Wiley Periodicals, Head Neck 39: 71-81, 2017.
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, European Institute of Oncology, Milan, Italy.
authors.forename: Mohssen
authors.initials: M
authors.lastname: Ansarin
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, European Institute of Oncology, Milan, Italy.
authors.forename: Augusto
authors.initials: A
authors.lastname: Cattaneo
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, European Institute of Oncology, Milan, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: De Benedetto
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, European Institute of Oncology, Milan, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Zorzi
authors.affiliation: Division of Pathology, European Institute of Oncology, Milan, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Lombardi
authors.affiliation: Division of Radiotherapy, European Institute of Oncology, Milan, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Alterio
authors.affiliation: Medical Oncology Division of Urogenital and Head and Neck Tumours, European Institute of Oncology, Milan, Italy.
authors.forename: Maria Cossu
authors.initials: MC
authors.lastname: Rocca
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, European Institute of Oncology, Milan, Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Scelsi
authors.affiliation: Division of Radiology, European Institute of Oncology, Milan, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Preda
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, European Institute of Oncology, Milan, Italy.
authors.forename: Fausto
authors.initials: F
authors.lastname: Chiesa
authors.affiliation: Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Santoro
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D005931:Glottis; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D053685:Laser Therapy; D008297:Male; D008866:Microsurgery; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome
keywords: laryngeal cancer; organ preservation; overall survival; relapse-free survival; transoral laryngeal microsurgery