title: Rice Hull Extract Suppresses Benign Prostate Hyperplasia by Decreasing Inflammation and Regulating Cell Proliferation in Rats.
abstract: Even though rice hull has various physiological functions with high antioxidant potential, the molecular mechanism(s) underlying the effects of rice hull on benign prostatic hyperplasia (BPH) have not been evaluated. The aim of this study was to determine the protective effect of rice hull water extract (RHE) against BPH, which is a common disorder in elderly men and involves inflammation that induces an imbalance between cell proliferation and cell death. In this study, RHE-treated mice exhibited lower prostate weights and ratios of prostate weight to body weight compared to those for the BPH-induced group. In addition, RHE-treated mice had lower serum levels of dihydrotestosterone, mRNA expression of 5α-reductase2, and protein expressions of proliferating cell nuclear antigen (PCNA). Furthermore, RHE treatment significantly decreased cell proliferation by regulating the expression levels of inflammatory-related proteins (iNOS and COX-2) and apoptosis-associated proteins (Fas, FADD, procaspase-8, -3, and Bcl-2 family proteins). These results suggest that RHE could protect against the development of BPH through its anti-inflammatory and apoptotic properties and has good potential as a treatment for BPH.
authors.affiliation: 1 Department of Pharmacology, College of Oriental Medicine, Sangji University , Wonju-si, Korea.
authors.forename: Chae-Yun
authors.initials: CY
authors.lastname: Kim
authors.affiliation: 1 Department of Pharmacology, College of Oriental Medicine, Sangji University , Wonju-si, Korea.
authors.forename: Kyung-Sook
authors.initials: KS
authors.lastname: Chung
authors.affiliation: 1 Department of Pharmacology, College of Oriental Medicine, Sangji University , Wonju-si, Korea.
authors.forename: Se-Yun
authors.initials: SY
authors.lastname: Cheon
authors.affiliation: 2 Department of Pharmacy, College of Pharmacy, Dongduk Women's University , Seoul, Korea.
authors.forename: Jong-Hyun
authors.initials: JH
authors.lastname: Lee
authors.affiliation: 1 Department of Pharmacology, College of Oriental Medicine, Sangji University , Wonju-si, Korea.
authors.forename: Youn-Bum
authors.initials: YB
authors.lastname: Park
authors.affiliation: 1 Department of Pharmacology, College of Oriental Medicine, Sangji University , Wonju-si, Korea.
authors.forename: Hyo-Jin
authors.initials: HJ
authors.lastname: An
mesh_terms: D058891:5-alpha Reductase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D017209:Apoptosis; D049109:Cell Proliferation / Q000187:drug effects*; D052246:Cyclooxygenase 2 Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D013196:Dihydrotestosterone / Q000097:blood; D006965:Hyperplasia; D007249:Inflammation / Q000097:blood* / Q000188:drug therapy; D008297:Male; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D012275:Oryza; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D018809:Proliferating Cell Nuclear Antigen / Q000097:blood; D011467:Prostate / Q000187:drug effects* / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000097:blood / Q000188:drug therapy / Q000473:pathology*; D017207:Rats, Sprague-Dawley; D012639:Seeds
chemical_list: D058891:5-alpha Reductase Inhibitors; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D052246:Cyclooxygenase 2 Inhibitors; D010936:Plant Extracts; D018809:Proliferating Cell Nuclear Antigen; D013196:Dihydrotestosterone; D052247:Nitric Oxide Synthase Type II
keywords: Bcl-2; apoptosis; benign prostatic hyperplasia (BPH); inflammation; proliferation; rice hull water extract (RHE)