title: Fibroblast growth factor 23 and soluble Klotho in patients with autosomal dominant polycystic kidney disease.
abstract: OBJECTIVE
  This study aimed to examine the roles of fibroblast growth factor 23 (FGF23) and soluble Klotho in phosphate metabolism in autosomal-dominant polycystic kidney disease (ADPKD) patients.
  
  
  METHODS
  We measured these two factors and phosphate metabolism parameters in 80 patients with ADPKD and 53 patients with non-diabetic chronic kidney disease (CKD).
  
  
  RESULTS
  The mean serum FGF23 level in the ADPKD group was significantly (twofold) higher than in the non-diabetic CKD patients, but the mean soluble Klotho level in the ADPKD group was significantly lower in the non-diabetic CKD group. The mean serum phosphate levels of the two groups were similar. The estimated glomerular filtration rate (eGFR) was approximately 45 mL/min per 1.73 m2in both groups, and their serum vitamin D metabolite levels were in the normal range.
  
  
  CONCLUSIONS
  The serum FGF23 levels were significantly higher and soluble Klotho levels significantly lower in the ADPKD group than in the non-diabetic CKD group matched for eGFR, and these findings may be associated with resistance of renal phosphate excretion.
authors.affiliation: Department of Medicine, Kidney Center, Tokyo Women's Medical University, Toyko, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Akiyama
authors.affiliation: Department of Medicine, Kidney Center, Tokyo Women's Medical University, Toyko, Japan.
authors.forename: Toshio
authors.initials: T
authors.lastname: Mochizuki
authors.affiliation: Department of Medicine, Kidney Center, Tokyo Women's Medical University, Toyko, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kataoka
authors.affiliation: Department of Medicine, Kidney Center, Tokyo Women's Medical University, Toyko, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Tsuchiya
authors.affiliation: Department of Medicine, Kidney Center, Tokyo Women's Medical University, Toyko, Japan.
authors.forename: Kosaku
authors.initials: K
authors.lastname: Nitta
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood / Q000502:physiology*; D005919:Glomerular Filtration Rate; D005966:Glucuronidase / Q000097:blood / Q000502:physiology*; D006801:Humans; D000090265:Klotho Proteins; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000378:metabolism; D016891:Polycystic Kidney, Autosomal Dominant / Q000097:blood / Q000503:physiopathology*
chemical_list: C000717427:FGF23 protein, human; D010710:Phosphates; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D005966:Glucuronidase; D000090265:Klotho Proteins
keywords: fibroblast growth factor 23; klotho; parathyroid hormone; phosphate; polycystic kidney disease