title: Evaluation of the Serum Levels of Nitric Oxide among Diabetic Patients and its Correlation with Lipid Profile as well as Oxidative Stress in North Indian Setting.
abstract: BACKGROUND
  Diabetes mellitus is a disease with a rapidly increasing prevalence, needs continue research for novel methods to both prevent and treat this disorder. Obesity and decreased physical activity are the major risk factor for the development of diabetes. Recently the emphasis is focused on oxidative stress in pathogenesis of this disease.
  
  
  OBJECTIVE
  To assess the serum levels of Nitric Oxide (NO) among diabetic patients and its correlation with lipid profile as well as oxidative stress in north Indian setting.
  
  
  METHODS
  This was a cross-sectional study. Subjects suffering from type 2 diabetes for more than 1 year and age between 30 to 50 years with hyperuricaemia were included in the study. The patients were divided into three groups: Group I- Type 2 diabetics with dyslipidemia and hyperuricaemia, Group II- Type 2 diabetics with dyslipidemia and normouricaemia and Group III- Type 2 diabetics with normolipidemia and normouricaemia.
  
  
  RESULTS
  The nitric oxide level was significantly lower in Group I and Group II than Group III. The oxidative stress parameters had poor correlation with NO level in all the groups.
  
  
  CONCLUSIONS
  Our data suggests that there is definite role of Nitric Oxide (NO) in pathogenesis of type -2 diabetes mellitus with dyslipidemia and hyperuricaemia.
authors.affiliation: Senior Resident, Department of Medicine, KG Medical University , Lucknow, India .
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Kumar
authors.affiliation: Professor, Department of Medicine, LLR Medical College , Meerut, India .
authors.forename: Arvind
authors.initials: A
authors.lastname: Trivedi
authors.affiliation: Junior Resident, Department of Obstetrics and Gynecology, MLB Medical College Jhansi UP, India .
authors.forename: Neetu
authors.initials: N
authors.lastname: Verma
authors.affiliation: Senior Resident, Department of Neurology, KG Medical University , Lucknow, India .
authors.forename: Ajay
authors.initials: A
authors.lastname: Panwar
authors.affiliation: Professor, Department of Physiology, KG Medical University , Lucknow, India .
authors.forename: Pradeep
authors.initials: P
authors.lastname: Kumar
keywords: Dyslipidemia; Free radical; HbA1c; Hyperuricaemia; Middle aged