title: Impact of total lesion glycolysis measured by18F-FDG-PET/CT on overall survival and distant metastasis in hypopharyngeal cancer.
abstract: The present study investigated the possible correlation between18F-2-fluorodeoxyglucose (18F-FDG)-uptake parameters and clinicopathological parameters in hypopharyngeal squamous cell carcinoma (HPSCC). A total of 53 patients, newly diagnosed with HPSCC, received pretreatment18F-FDG-positron emission tomography/computed tomography (PET/CT). Metabolic tumor volume (MTV), total lesion glycolysis (TLG), and maximum and peak standardized uptake values (SUVmax and SUVpeak) were calculated as18F-FDG-uptake parameters of the primary tumor. Tumor thickness, depth of invasion and pathological tumor volume were pathologically measured. Upon univariate survival analysis, SUVmax ≥28.5, SUVpeak ≥19, MTV ≥12 and TLG ≥42 were significantly associated with a shorter overall survival (OS) time, and MTV ≥12 and TLG ≥42 were significantly associated with a shorter distant metastasis-free survival (DMFS) time. Upon multivariate analysis with adjustment for clinical T category and treatment group, patients with SUVmax ≥28.5 exhibited a significantly shorter OS time, while TLG ≥42 was significantly correlated with shorter OS and DMFS times. Upon simple regression analysis, TLG was found to be significantly associated with tumor thickness and depth of invasion, while MTV was found to be closely associated with pathological tumor volume. In conclusion, pretreatment18F-FDG-PET/CT is likely to provide valuable prognostic parameters in HPSCC.
authors.affiliation: Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Aichi 464-8681, Japan.
authors.forename: Hidenori
authors.initials: H
authors.lastname: Suzuki
authors.affiliation: Department of Radiology, Nagoya Positron Emission Tomography Imaging Center, Nagoya, Aichi 454-0933, Japan.
authors.forename: Masami
authors.initials: M
authors.lastname: Nishio
authors.affiliation: Department of Pathology, Aichi Cancer Center Aichi Hospital, Okazaki, Aichi 444-0011, Japan.
authors.forename: Hayao
authors.initials: H
authors.lastname: Nakanishi
authors.affiliation: Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Aichi 464-8681, Japan.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Hanai
authors.affiliation: Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Aichi 464-8681, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Hirakawa
authors.affiliation: Department of Radiation Oncology, Aichi Cancer Center Hospital, Nagoya, Aichi 464-8681, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kodaira
authors.affiliation: Department of Radiology, East Nagoya Positron Emission Tomography Imaging Center, Nagoya, Aichi 464-0044, Japan.
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Tamaki
authors.affiliation: Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Aichi 464-8681, Japan.
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Hasegawa
keywords: 18F-2-fluorodeoxyglucose-positron emission tomography/computed tomography; 18F-2-fluorodeoxyglucose-uptake parameter; distant metastasis; hypopharyngeal squamous cell carcinoma; overall survival