title: An Uncommon Cause of Stroke: Non-bacterial Thrombotic Endocarditis.
abstract: Our objective is to present the case of an uncommon but probably under-recognized cause of stroke: Non-bacterial thrombotic endocarditis (NBTE). A 59-year-old man presented to our hospital with multiple bihemispheric infarcts despite taking rivaroxaban for pulmonary emboli diagnosed 2 weeks earlier. The patient's symptoms progressed quickly and he died within a week of his initial presentation despite attempts at neuroradiologically guided clot retrieval and early recognition and treatment of disseminated intravascular coagulation. On postmortem examination it was discovered that he had an undiagnosed squamous cell adenocarcinoma of the lung and NBTE. NBTE is difficult to diagnose and difficult to treat. It is associated with a mortality rate and is often not diagnosed until autopsy. However there are case reports in the literature where NBTE has been successfully treated. Early recognition and prompt treatment of the underlying disease process is the essential first step.
authors.affiliation: St George's Hospital, London, UK. Electronic address: hildemarlene@hotmail.com.
authors.forename: Hilde
authors.initials: H
authors.lastname: Gundersen
authors.affiliation: St George's Hospital, London, UK.
authors.forename: Barry
authors.initials: B
authors.lastname: Moynihan
mesh_terms: D001706:Biopsy; D002533:Cerebral Angiography; D018450:Disease Progression; D004211:Disseminated Intravascular Coagulation / Q000209:etiology; D059905:Endocarditis, Non-Infective / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D017809:Fatal Outcome; D006801:Humans; D020767:Intracranial Thrombosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
keywords: Stroke; disseminated intravascular coagulation; marantic endocarditis; non-bacterial thrombotic endocarditis