title: Deconvoluting the complexity of microRNAs in autophagy to improve potential cancer therapy.
abstract: MicroRNAs (miRNAs) (small, non-coding RNAs ∼22 nucleotides [nt] in length), have been estimated to regulate in the region of 30% of human gene expression at the post-transcriptional and translational levels. They are also involved in a series of important cellular processes, such as autophagy. Autophagy is well-known to be an evolutionarily conserved lysosomal degradation process in which a cell degrades long-lived proteins and damaged organelles. Recent evidence has shown that miRNAs can function as either oncogenes or tumour-suppressive genes in human cancers. Also, they are well-characterized to be crucial in tumourigenesis, as either oncogenes or tumour suppressors, by regulating autophagy. However, discovering the intricate mechanism of miRNA-modulated autophagy remains in its infancy. Thus, in this review, we focus on summarizing the dual function of oncogenic or tumour-suppressive miRNAs in regulation of autophagy and their roles in carcinogenesis, thereby revealing the regulatory mechanism of miRNA-modulated autophagy in cancer, to shed light on more novel RNA therapeutic strategies in the future.
authors.affiliation: Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China.
authors.forename: Dahong
authors.initials: D
authors.lastname: Yao
authors.affiliation: Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China.
authors.forename: Yingnan
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China.
authors.forename: Suyu
authors.initials: S
authors.lastname: Gao
authors.affiliation: School of Pharmacy, China Medical University, Shenyang, 110122, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Shang
authors.affiliation: Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China.
authors.forename: Yuqian
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Huang
authors.affiliation: Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China. profwjh@126.com.
authors.forename: Jinhui
authors.initials: J
authors.lastname: Wang
authors.affiliation: Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China. yangshilin@suda.edu.cn.
authors.forename: Shilin
authors.initials: S
authors.lastname: Yang
authors.affiliation: Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China. syzyclx@163.com.
authors.forename: Lixia
authors.initials: L
authors.lastname: Chen
mesh_terms: D000818:Animals; D001343:Autophagy; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D015316:Genetic Therapy; D006801:Humans; D035683:MicroRNAs / Q000032:analysis / Q000235:genetics* / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D009857:Oncogenes; D015398:Signal Transduction
chemical_list: D035683:MicroRNAs