title: Ghrelin attenuates hyperalgesia and light aversion-induced by nitroglycerin in male rats.
abstract: Systemic administration of nitroglycerin (NTG) consistently provokes spontaneous-like migraine attacks in migraine sufferers, and in rat it induces hyperalgesia and allodynia. In the present study we modeled migraine headache by intraperitoneal (i.p.) injection of a single dose of NTG, which produced widespread thermal allodynia and mechanical hyperalgesia, photophobia, and increased anxiety-like behaviors and serum concentration of cortisol. Results suggest that the effects of NTG can be largely reversed by administration of ghrelin, which mimics the effects of sumatriptan used as relevant positive therapeutic control in this study. These findings suggest that ghrelin may alleviate some of the negative emotional states associated with migraine and may hold therapeutic potential in treating migraine headache.
authors.affiliation: Neuroscience Research Center of Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Fereshteh
authors.initials: F
authors.lastname: Farajdokht
authors.affiliation: Neuroscience Research Center of Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Shirin
authors.initials: S
authors.lastname: Babri
authors.affiliation: Neuroscience Research Center of Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Pouran
authors.initials: P
authors.lastname: Karimi
authors.affiliation: Drug Applied Research Center of Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: Mohaddesg@tbzmed.ac.ir.
authors.forename: Gisou
authors.initials: G
authors.lastname: Mohaddes
mesh_terms: D000818:Animals; D001007:Anxiety / Q000209:etiology / Q000517:prevention & control*; D004195:Disease Models, Animal; D054439:Ghrelin / Q000008:administration & dosage*; D006930:Hyperalgesia / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D008881:Migraine Disorders / Q000139:chemically induced / Q000150:complications*; D005996:Nitroglycerin; D020795:Photophobia / Q000209:etiology / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D012668:Trigeminal Ganglion / Q000187:drug effects / Q000378:metabolism
chemical_list: D054439:Ghrelin; D005996:Nitroglycerin
keywords: Cortisol; Ghrelin; Hyperalgesia; Light aversion; Nitroglycerin