title: Cerebellar volume deficits in medication-naïve obsessive compulsive disorder.
abstract: Even though conventional neurobiological models of obsessive compulsive disorder (OCD) commonly demonstrate abnormalities involving fronto-striatal circuits, there is emerging evidence regarding the role of posterior brain structures such as cerebellum. In this study, we examined the cerebellar regional volume in a large sample of medication-naïve OCD patients compared to matched healthy controls (HC). In 49 medication naïve right handed OCD patients and 39 age and sex matched HC, sub-region wise volume of cerebellum was extracted from the T1 weighted images using Spatially Unbiased Infra tentorial Template (SUIT) toolbox and compared using hypothesis driven, region of interest approach after clinical assessment with standard scales. After controlling for age, sex and ICV, the subjects with OCD had significantly smaller cerebellum compared to HC, especially in the posterior lobe sub-regions - lobule VI and left crus 1. This study gives preliminary evidence for region specific cerebellar volumetric deficits in the pathophysiological of OCD. Regional cerebellar volume deficits conform to the abnormal connectivity of cerebellum to specific cortical regions and it is indicative of involvement of regions outside the conventional fronto-striatal circuitry. This might be important in the context of cognitive deficits seen in OCD.
authors.affiliation: Obsessive-Compulsive Disorder Clinic, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore 560029, India; Translational Psychiatry Laboratory, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences, Bangalore 560029, India.
authors.forename: Janardhanan C
authors.initials: JC
authors.lastname: Narayanaswamy
authors.affiliation: Translational Psychiatry Laboratory, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences, Bangalore 560029, India.
authors.forename: Dania
authors.initials: D
authors.lastname: Jose
authors.affiliation: Translational Psychiatry Laboratory, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences, Bangalore 560029, India.
authors.forename: Sunil V
authors.initials: SV
authors.lastname: Kalmady
authors.affiliation: Obsessive-Compulsive Disorder Clinic, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore 560029, India; Translational Psychiatry Laboratory, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences, Bangalore 560029, India.
authors.forename: Sri Mahavir
authors.initials: SM
authors.lastname: Agarwal
authors.affiliation: Obsessive-Compulsive Disorder Clinic, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore 560029, India; Translational Psychiatry Laboratory, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences, Bangalore 560029, India. Electronic address: venkat.nimhans@gmail.com.
authors.forename: Ganesan
authors.initials: G
authors.lastname: Venkatasubramanian
authors.affiliation: Obsessive-Compulsive Disorder Clinic, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore 560029, India.
authors.forename: Y C
authors.initials: YC
authors.lastname: Janardhan Reddy
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D016022:Case-Control Studies; D002531:Cerebellum / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D002540:Cerebral Cortex / Q000503:physiopathology; D060825:Cognitive Dysfunction / Q000000981:diagnostic imaging* / Q000473:pathology / Q000523:psychology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000503:physiopathology; D009771:Obsessive-Compulsive Disorder / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology / Q000523:psychology; D009929:Organ Size; D055815:Young Adult
keywords: Cerebellum; MRI; Obsessive compulsive disorder