title: [A Case of Portal Vein Thrombosis Occurring during CapeOX and Bevacizumab Combination Therapy for Liver Metastasis].
abstract: A73 -year-old man underwent a sigmoidectomy for sigmoid colon cancer with liver metastasis. After the operation, he received CapeOX combined with bevacizumab therapy. After 6 courses, the liver metastasis was undetectable on computed tomography scans. After 15 courses, computed tomography revealed ascites, and chemotherapy was discontinued. Two months later, computed tomography revealed portal vein thrombosis. Owing to the chronic nature of the thrombosis, thrombolytic therapy was not initiated. However, preservation therapy using antiplatelet drugs for 1 month resolved the ascites and the thrombosis. The risk of serious thrombosis must be considered when using bevacizumab.
authors.affiliation: Dept. of Surgery, Nagoya Memorial Hospital.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Uno
authors.forename: Kenji
authors.initials: K
authors.lastname: Tsuboi
authors.forename: Mitsuya
authors.initials: M
authors.lastname: Shimizu
authors.forename: Toshihide
authors.initials: T
authors.lastname: Tomosugi
authors.forename: Michita
authors.initials: M
authors.lastname: Shoka
authors.forename: Soki
authors.initials: S
authors.lastname: Hibino
authors.forename: Hidenobu
authors.initials: H
authors.lastname: Matsushita
authors.forename: Takuji
authors.initials: T
authors.lastname: Takahashi
authors.forename: Osamu
authors.initials: O
authors.lastname: Okochi
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Kawase
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001241:Aspirin / Q000627:therapeutic use; D000068258:Bevacizumab / Q000008:administration & dosage; D000069287:Capecitabine / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D000077150:Oxaliplatin; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011169:Portal Vein / Q000000981:diagnostic imaging*; D012811:Sigmoid Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000139:chemically induced* / Q000188:drug therapy
chemical_list: D009944:Organoplatinum Compounds; D010975:Platelet Aggregation Inhibitors; D000077150:Oxaliplatin; D000068258:Bevacizumab; D000069287:Capecitabine; D001241:Aspirin