title: Retinal Oximetry in a Healthy Japanese Population.
abstract: OBJECTIVE
  To establish the normative database of retinal oximetry using Oxymap T1 in a healthy Japanese population, and study the reproducibility of the measurements in Japanese.
  
  
  METHODS
  We measured oxygen saturation in the major retinal vessels with Oxymap T1 in 252 eyes of 252 healthy Japanese subjects. Fundus images acquired using Oxymap T1 were processed using built-in Oxymap Analyzer software. Reproducibility of retinal oximetry was investigated using 20 eyes of 20 healthy subjects.
  
  
  RESULTS
  The mean retinal oxygen saturation of 4 quadrants in healthy Japanese was 97.0 ± 6.9% in arteries and 52.8 ± 8.3% in veins. The mean arteriovenous difference in oxygen saturation was 44.2 ± 9.2%. Both arterial and venous oxygen saturation were significantly lower in the temporal side of the retina, especially in the temporal-inferior vessels. However, the arteriovenous difference in oxygen saturation was limited in the 4 quadrants. Interphotograph, intervisit, and interevaluator intraclass correlation coefficients were 0.936-0.979, 0.809-0.837, and 0.732-0.947, respectively. In the major retinal arteries, oxygen saturation increased with age (r = 0.18, p<0.01), at a rate of 0.67% per 10 years. However, venous oxygen saturation showed no correlation with age.
  
  
  CONCLUSIONS
  This study provides the normative database for the Japanese population. The arterial saturation value appears to be higher than other previous studies. Mean retinal oximetry in 4 quadrants with Oxymap T1 has high reproducibility.
authors.affiliation: Department of Ophthalmology, Kagawa University Faculty of Medicine, Miki, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Nakano
authors.affiliation: Department of Ophthalmology, Kagawa University Faculty of Medicine, Miki, Japan.
authors.forename: Takeru
authors.initials: T
authors.lastname: Shimazaki
authors.affiliation: Department of Ophthalmology, Kagawa University Faculty of Medicine, Miki, Japan.
authors.forename: Nobuko
authors.initials: N
authors.lastname: Kobayashi
authors.affiliation: Department of Ophthalmology, Kagawa University Faculty of Medicine, Miki, Japan.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Miyoshi
authors.affiliation: Department of Ophthalmology, Kagawa University Faculty of Medicine, Miki, Japan.
authors.forename: Aoi
authors.initials: A
authors.lastname: Ono
authors.affiliation: Department of Ophthalmology, Kagawa University Faculty of Medicine, Miki, Japan.
authors.forename: Mamoru
authors.initials: M
authors.lastname: Kobayashi
authors.affiliation: Department of Ophthalmology, Kagawa University Faculty of Medicine, Miki, Japan.
authors.forename: Chieko
authors.initials: C
authors.lastname: Shiragami
authors.affiliation: Department of Ophthalmology, Kagawa University Faculty of Medicine, Miki, Japan.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Hirooka
authors.affiliation: Department of Ophthalmology, Kagawa University Faculty of Medicine, Miki, Japan.
authors.forename: Akitaka
authors.initials: A
authors.lastname: Tsujikawa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D007564:Japan; D008297:Male; D008875:Middle Aged; D010092:Oximetry / Q000379:methods*; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption / Q000502:physiology*; D011446:Prospective Studies; D012016:Reference Values; D015203:Reproducibility of Results; D012160:Retina / Q000502:physiology*; D012161:Retinal Artery / Q000502:physiology*; D012169:Retinal Vein / Q000502:physiology*; D012984:Software
chemical_list: D010100:Oxygen