title: Multiplexed Molecular Diagnostics for Respiratory, Gastrointestinal, and Central Nervous System Infections.
abstract: The development and implementation of highly multiplexed molecular diagnostic tests have allowed clinical microbiology laboratories to more rapidly and sensitively detect a variety of pathogens directly in clinical specimens. Current US Food and Drug Administration-approved multiplex panels target multiple different organisms simultaneously and can identify the most common pathogens implicated in respiratory viral, gastrointestinal, or central nervous system infections. This review summarizes the test characteristics of available assays, highlights the advantages and limitations of multiplex technology for infectious diseases, and discusses potential utilization of these new tests in clinical practice.
authors.affiliation: Divisions of Infectious Diseases.|Clinical Microbiology, University of Utah and ARUP Laboratories, Salt Lake City.
authors.forename: Kimberly E
authors.initials: KE
authors.lastname: Hanson
authors.affiliation: Clinical Microbiology, University of Utah and ARUP Laboratories, Salt Lake City.
authors.forename: Marc Roger
authors.initials: MR
authors.lastname: Couturier
mesh_terms: D001419:Bacteria / Q000145:classification / Q000235:genetics; D001424:Bacterial Infections / Q000175:diagnosis / Q000382:microbiology; D002494:Central Nervous System Infections / Q000175:diagnosis / Q000382:microbiology / Q000821:virology; D005767:Gastrointestinal Diseases / Q000175:diagnosis / Q000382:microbiology / Q000821:virology; D006801:Humans; D025202:Molecular Diagnostic Techniques / Q000379:methods*; D012141:Respiratory Tract Infections / Q000175:diagnosis / Q000382:microbiology / Q000821:virology; D014777:Virus Diseases / Q000175:diagnosis / Q000821:virology; D014780:Viruses / Q000145:classification / Q000235:genetics
keywords: gastrointestinal; meningoencephalitis; molecular diagnostics; respiratory