title: Long term follow-up of "full metal jacket" of de novo coronary lesions with new generation Zotarolimus-eluting stents.
abstract: BACKGROUND
  Diffuse coronary artery disease treatment still remains a challenge for interventional cardiologists and cardiac surgeons. There are few data on full metal jacket (FMJ) stenting, especially with new-generation drug-eluting stents. We aimed to assess the efficacy and safety of FMJ with new-generation Zotarolimus-eluting stents (n-ZES).
  
  
  RESULTS
  All patients who underwent FMJ with n-ZES (≥60mm stent length) in eleven Italian interventional centers participating in the Clinical Service® project were included in this analysis. The project population consisted of 120 patients and 122 lesions. Mean age was 67±10years and 95 (79.2%) patients were male. A chronic total occlusion was present in 34 lesions (27.9%). The number of stents implanted per lesion was 2.9±0.8, and the diameter of the stents was 3.0±0.5mm. Predilation and post-dilatation were performed in 107 (87.7%) and 92 (75.4%) patients, respectively. At 41±21month follow-up there were 2 patients with subacute definite stent thrombosis, 6 patients (5.0%) had cardiac death and 5 patients (4.2%) had non-fatal myocardial infarction. Seven patients (5.8%) underwent clinically-driven target lesion revascularization. Fourteen patients (11.7%) had at least one major adverse cardiac event.
  
  
  CONCLUSIONS
  The treatment of diffuse coronary artery disease with FMJ stenting with n-ZES appears to be effective and safe. Late and very-late ST does not seem to be an issue and the rate of restenosis and of major cardiac adverse events after more than 3-year follow-up is rather low.
authors.affiliation: Unità Operativa Complessa di Cardiologia, Ospedale Valduce, Como, Italy. Electronic address: durante.alessandro@gmail.com.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Durante
authors.affiliation: Dipartimento Cardiovascolare, Università Cattolica del Sacro Cuore, Roma, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Foglia Manzillo
authors.affiliation: Dipartimento Cardiovascolare, Università Cattolica del Sacro Cuore, Roma, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Burzotta
authors.affiliation: Dipartimento Cardiovascolare, Università Cattolica del Sacro Cuore, Roma, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Trani
authors.affiliation: Dipartimento Cardiovascolare, Università Cattolica del Sacro Cuore, Roma, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Aurigemma
authors.affiliation: Unità Di Cardiologia, Policlinico Casilino, Rome, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Summaria
authors.affiliation: Unità Di Cardiologia, Policlinico Casilino, Rome, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Patrizi
authors.affiliation: Unità Di Cardiologia, Policlinico Casilino, Rome, Italy.
authors.forename: Giovanni Paolo
authors.initials: GP
authors.lastname: Talarico
authors.affiliation: Unità Di Emodinamica e Cardiologia Interventistica, Ospedale San Raffaele, Milan, Italy.
authors.forename: Azeem
authors.initials: A
authors.lastname: Latib
authors.affiliation: Unità Di Emodinamica e Cardiologia Interventistica, Ospedale San Raffaele, Milan, Italy.
authors.forename: Filippo
authors.initials: F
authors.lastname: Figini
authors.affiliation: Unità di Emodinamica e Cardiologia Interventistica - Ospedale di Belcolle, Viterbo, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Romagnoli
authors.affiliation: Unità Operativa Di Cardiologia, Azienda Ospedaliera Morgagni Pierantoni, Forlì, Italy.
authors.forename: Mariarosaria
authors.initials: M
authors.lastname: De Vita
authors.affiliation: Unità Operativa Di Cardiologia, Istituto Clinico Humanitas Mater Domini, Castellanza, Italy.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Fantoni
authors.affiliation: Unità di Cardiologia, Casa di Cura Villa Verde, Taranto, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: My
authors.affiliation: Unità Di Cardiologia, Ospedale Lorenzo Bonomo, Andria, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Larosa
authors.affiliation: Unità di Emodinamica e Cardiologia Interventistica, Azienda Ospedaliera San Giovanni Addolorata, Rome, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Manzoli
authors.affiliation: UOC Cardiologia, Presidio Ospedaliero Di Venere, Bari Carbonara, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Turturo
authors.affiliation: UOC Cardiologia, Azienda Ospedaliera Sant'Andrea, Roma, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Berni
authors.affiliation: Unità Operativa Complessa di Cardiologia, Ospedale Valduce, Como, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Corrado
mesh_terms: D000368:Aged; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000401:mortality / Q000601:surgery; D023903:Coronary Restenosis / Q000209:etiology / Q000401:mortality; D054855:Drug-Eluting Stents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D000069451:Long Term Adverse Effects / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology / Q000209:etiology; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods; D011183:Postoperative Complications / Q000453:epidemiology; D012720:Severity of Illness Index; D016896:Treatment Outcome
keywords: DES; Drug eluting stent; Full metal jacket; PCI; ZES