title: [Can ischemia-modified albumin help in differentiating myocardial perfusion scintigraphy results?].
abstract: OBJECTIVE
  Myocardial perfusion scintigraphy (MPS) is a diagnostic tool commonly used to detect significant coronary lesion. However equivocal, false negative or positive results can be yielded. Controversial findings regarding the role of ischemia-modified albumin (IMA) in MPS evaluation persist. The aim of the present study was to examine the role of serum IMA in the assessment of MPS results.
  
  
  METHODS
  MPS using technetium (99mTc) sestamibi and transthoracic echocardiography was performed on 62 consecutive subjects prospectively enrolled. Exercise treadmill test (ETT) with modified Bruce protocol was used to induce coronary ischemia. During MPS performance, blood samples for serum IMA were obtained at 3 times: at pre-exercise, at the peak of ETT, and 6 hours after ETT. Patients were classified into 3 groups according to MPS results (normal, equivocal, and ischemia).
  
  
  RESULTS
  Sixty-two patients (23 normal, 20 equivocal, 19 with ischemia) were included. Pre- and peak-exercise IMA values were similar among the groups (p=0.706 and 0.904). Post-exercise IMA values of the normal and equivocal groups were similar (p=0.733), while that of the ischemia group was significantly higher than the values of either the normal (p<0.001) or equivocal groups (p<0.001). ΔIMA (the difference between post-exercise and peak-exercise IMA) of the ischemia group was significantly higher than that of either the normal (p<0.001) or equivocal groups (p<0.001).
  
  
  CONCLUSIONS
  Serum IMA was found to be significantly increased in cases of ischemia on MPS. Subjects with normal and equivocal MPS had a similar pattern during the test. IMA may be used in differentiation of equivocal results from false positive results.
authors.affiliation: Department of Cardiology, Bozok University Faculty of Medicine, Yozgat, Turkey. huseyinede@yahoo.com.
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Ede
authors.affiliation: Department of Cardiology, Diyarbakır Gazi Yaşargil Training and Research Hospital, Diyarbakır, Turkey.
authors.forename: Barış
authors.initials: B
authors.lastname: Yaylak
authors.affiliation: Department of Cardiology, Diyarbakır Gazi Yaşargil Training and Research Hospital, Diyarbakır, Turkey.
authors.forename: Süleyman
authors.initials: S
authors.lastname: Akkaya
authors.affiliation: Department of Nuclear Medicine, Bozok University Faculty of Medicine, Yozgat, Turkey.
authors.forename: Seyhan
authors.initials: S
authors.lastname: Karaçavuş
authors.affiliation: Department of Biochemistry, Bozok University Faculty of Medicine, Yozgat, Turkey.
authors.forename: Ayşe Yeşim
authors.initials: AY
authors.lastname: Göçmen
authors.affiliation: Department of Cardiology, Bozok University Faculty of Medicine, Yozgat, Turkey.
authors.forename: Ali Rıza
authors.initials: AR
authors.lastname: Erbay
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D057791:Cardiac Imaging Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055420:Perfusion Imaging / Q000379:methods*; D012709:Serum Albumin; D000075462:Serum Albumin, Human; D017256:Technetium Tc 99m Sestamibi / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D015415:Biomarkers; D012709:Serum Albumin; C561522:ischemia-modified albumin; D017256:Technetium Tc 99m Sestamibi; D000075462:Serum Albumin, Human