title: Four New Kaurane Diterpenoids from the Chinese Liverwort Jungermannia comata Nees.
abstract: In our continuing program to find new bioactive compounds from the Chinese liverworts, four new kaurane-type diterpenoids, (6β)-kaur-16-ene-6,9-diol (1), (6β,12β)-kaur-16-ene-6,9,12-triol (2), (6β)-kaur-16-ene-5,6,9-triol (3), and kaur-16-ene-9,19-diol (4), have been isolated from the Chinese liverwort Jungermannia comata Nees. Five known kaurane-type diterpenoids (5 - 9) and four known trachylobane-type diterpenoids (10 - 13) were also obtained. The structures of the new compounds were established unequivocally on the basis of spectroscopic data. The absolute configuration of compound 1 was established by comparing experimental and calculated electronic circular dichroism spectra.
authors.affiliation: State Key Laboratory of Microbial Technology, Shandong University-Helmholtz Institute of Biotechnology, School of Life Sciences, Shandong University, Shanda Nanlu 27, Jinan, 250100, P. R. China.|Key Lab of Chemical Biology of Ministry of Education, Department of Natural Products Chemistry, School of Pharmaceutical Science, Shandong University, No. 44 West Wenhua Road, Jinan, 250012, P. R. China.
authors.forename: Rui-Juan
authors.initials: RJ
authors.lastname: Li
authors.affiliation: Key Lab of Chemical Biology of Ministry of Education, Department of Natural Products Chemistry, School of Pharmaceutical Science, Shandong University, No. 44 West Wenhua Road, Jinan, 250012, P. R. China.|Shandong Institute for Food and Drug Control, No. 2749 Xinluo Road, New and High-tech Developing Zone, Jinan, 250101, P. R. China.
authors.forename: Song
authors.initials: S
authors.lastname: Wang
authors.affiliation: Key Lab of Chemical Biology of Ministry of Education, Department of Natural Products Chemistry, School of Pharmaceutical Science, Shandong University, No. 44 West Wenhua Road, Jinan, 250012, P. R. China.
authors.forename: Gang
authors.initials: G
authors.lastname: Li
authors.affiliation: Key Lab of Chemical Biology of Ministry of Education, Department of Natural Products Chemistry, School of Pharmaceutical Science, Shandong University, No. 44 West Wenhua Road, Jinan, 250012, P. R. China.
authors.forename: Jin-Chuan
authors.initials: JC
authors.lastname: Zhou
authors.affiliation: Key Lab of Chemical Biology of Ministry of Education, Department of Natural Products Chemistry, School of Pharmaceutical Science, Shandong University, No. 44 West Wenhua Road, Jinan, 250012, P. R. China.
authors.forename: Jiao-Zhen
authors.initials: JZ
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Microbial Technology, Shandong University-Helmholtz Institute of Biotechnology, School of Life Sciences, Shandong University, Shanda Nanlu 27, Jinan, 250100, P. R. China.
authors.forename: You-Ming
authors.initials: YM
authors.lastname: Zhang
authors.affiliation: Shandong Institute for Food and Drug Control, No. 2749 Xinluo Road, New and High-tech Developing Zone, Jinan, 250101, P. R. China.
authors.forename: Guo-Sheng
authors.initials: GS
authors.lastname: Shi
authors.affiliation: Key Lab of Chemical Biology of Ministry of Education, Department of Natural Products Chemistry, School of Pharmaceutical Science, Shandong University, No. 44 West Wenhua Road, Jinan, 250012, P. R. China.
authors.forename: Hong-Xiang
authors.initials: HX
authors.lastname: Lou
mesh_terms: D002681:China; D002942:Circular Dichroism; D045786:Diterpenes, Kaurane / Q000737:chemistry / Q000302:isolation & purification*; D035926:Hepatophyta / Q000737:chemistry*; D008968:Molecular Conformation
chemical_list: D045786:Diterpenes, Kaurane
keywords: 
  Jungermannia comata
  ; Electronic circular dichroism; Kaurane-type diterpenoids