title: Imaging of genetic and degenerative disorders primarily causing Parkinsonism.
abstract: In this chapter the structural and functional imaging changes associated with both genetic causes of Parkinson's disease and the sporadic condition are reviewed. The role of imaging for supporting diagnosis and detecting subclinical disease is discussed and the potential use and drawbacks of using imaging biomarkers for monitoring disease progression are debated. Additionally, the use of imaging for differentiating atypical parkinsonian syndromes from Parkinson's disease is presented.
authors.affiliation: Department of Medicine, Imperial College London, London, UK. Electronic address: david.brooks@imperial.ac.uk.
authors.forename: David J
authors.initials: DJ
authors.lastname: Brooks
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging*; D004298:Dopamine / Q000378:metabolism; D006801:Humans; D007091:Image Processing, Computer-Assisted; D019636:Neurodegenerative Diseases / Q000150:complications*; D059906:Neuroimaging; D020734:Parkinsonian Disorders / Q000000981:diagnostic imaging / Q000209:etiology / Q000235:genetics
chemical_list: D004298:Dopamine
keywords: MRI; MSA; PET; PSP; Parkinson; SPECT; genetic; sonography