title: Is the peripheral arterial disease in low risk type 2 diabetic patients influenced by body mass index, lipidemic control, and statins?
abstract: OBJECTIVE
  To correlate BMI, lipidemic control, and statin therapy with PAD measured by ABI in low risk type 2 diabetics.
  
  
  METHODS
  A sample of 101 nonsmoking, asymptomatic type 2 diabetics (50 males, 51 females) with known glycemic (fasting blood sugar, postprandial blood sugar, glycosylated hemoglobin) and lipidemic (total cholesterol, lipoproteins, and triglycerides [TGAs]) control was taken. Vascular Doppler was used to derive ABI and PAD was defined as ABI <0.9. ABI values were compared amongst groups and P < 0.05 was considered statistically significant.
  
  
  RESULTS
  We found fairly good lipid but poor glycemic control and prevalence of PAD 30%. There was insignificantly low ABI profile in patient having BMI ≥25, hyperlipidemia and absent statin therapy with odds ratio being highest for TGAs ≥150 (3.23) followed by BMI ≥25 (2.61), high-density lipoprotein ≤50 (1.61), low-density lipoprotein ≥100 (1.20), and disuse of statin (1.14) with significance only for BMI.
  
  
  CONCLUSIONS
  We observed small, insignificant PAD risk by dyslipidemia or non-use of statins in low-risk ambulatory T2DM patients, not so by BMI. This suggests importance of good glycemic control, maintenance of optimum weight, and lifestyle modifications as primary prevention rather than opting for costly and inefficient secondary prevention.
authors.affiliation: Department of Physiology, Government Medical College, Bhavnagar, Gujarat, India.
authors.forename: Jayesh Dalpatbhai
authors.initials: JD
authors.lastname: Solanki
authors.affiliation: Department of Physiology, Government Medical College, Bhavnagar, Gujarat, India.
authors.forename: Amit H
authors.initials: AH
authors.lastname: Makwana
authors.affiliation: Department of Physiology, Government Medical College, Bhavnagar, Gujarat, India.
authors.forename: Hemant B
authors.initials: HB
authors.lastname: Mehta
authors.affiliation: Department of Physiology, Government Medical College, Bhavnagar, Gujarat, India.
authors.forename: Pradnya A
authors.initials: PA
authors.lastname: Gokhale
authors.affiliation: Department of Physiology, Government Medical College, Bhavnagar, Gujarat, India.
authors.forename: Chinmay J
authors.initials: CJ
authors.lastname: Shah
keywords: Ankle-brachial index; lipidemic control; peripheral artery disease; statin; type 2 diabetes mellitus