title: Comparison of anterior cervical discectomy and fusion with the zero-profile device versus plate and cage in treating cervical degenerative disc disease: A meta-analysis.
abstract: Zero-profile device was applied to diminish the irritation of the esophagus in the treatment of cervical degenerative disc disease. However, the clinical application of the zero-profile device has not been testified with clinical evidence. The aim of the meta-analysis was to systematically compare the safety and effectiveness of anterior cervical discectomy and fusion with zero-profile device with plate and cage for the treatment of cervical degenerative disc disease. Electronic searches of PubMed and Embase were conducted up to May 2015. Relevant studies were included. Weighted mean difference (WMD) and 95% confidence intervals (CI) were assessed for continuous data. Risk ratio (RR) and 95% CI were assessed for dichotomous data. P value <0.05 was considered to be significant. Eleven studies were included in the meta-analysis. Compared with plate and cage, zero-p is associated with lower operation time of two-level surgery, less intraoperative blood loss, higher subsidence rate, higher JOA score, lower incidence of dysphagia in short-term (RR: 0.72, 95% CI [0.58, 0.90], P=0.005, I2=22%) and long-term (RR: 0.12, 95% CI [0.05, 0.30], P<0.00001, I2=0%) and lower Cobb angle of multilevel surgery (WMD: -3.16, 95% CI: [-4.35, -1.97], P<0.00001, I2=0%). No significant difference was found in one-level and two-level Cobb angle, fusion rate and operation time of one-level and three-level surgery. Both zero-p implantation and the plate and cage have respective advantages and disadvantages.
authors.affiliation: Department of Orthopaedic Surgery, West China Hospital, Sichuan University, Guoxue Lane 37, Chengdu 610041, Sichuan Province, China.
authors.forename: Yuchen
authors.initials: Y
authors.lastname: Duan
authors.affiliation: Department of Orthopaedic Surgery, West China Hospital, Sichuan University, Guoxue Lane 37, Chengdu 610041, Sichuan Province, China.
authors.forename: Yunbei
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Orthopaedic Surgery, West China Hospital, Sichuan University, Guoxue Lane 37, Chengdu 610041, Sichuan Province, China.
authors.forename: Yayi
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Orthopaedic Surgery, West China Hospital, Sichuan University, Guoxue Lane 37, Chengdu 610041, Sichuan Province, China. Electronic address: liuhao6304@126.com.
authors.forename: Hao
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Orthopaedic Surgery, West China Hospital, Sichuan University, Guoxue Lane 37, Chengdu 610041, Sichuan Province, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Hong
authors.affiliation: Department of Orthopaedic Surgery, West China Hospital, Sichuan University, Guoxue Lane 37, Chengdu 610041, Sichuan Province, China.
authors.forename: Quan
authors.initials: Q
authors.lastname: Gong
authors.affiliation: Department of Orthopaedic Surgery, West China Hospital, Sichuan University, Guoxue Lane 37, Chengdu 610041, Sichuan Province, China.
authors.forename: Yueming
authors.initials: Y
authors.lastname: Song
mesh_terms: D002574:Cervical Vertebrae / Q000601:surgery*; D017586:Diskectomy / Q000009:adverse effects / Q000295:instrumentation* / Q000592:standards; D006801:Humans; D016268:Internal Fixators / Q000009:adverse effects / Q000592:standards*; D055959:Intervertebral Disc Degeneration / Q000601:surgery*; D013123:Spinal Fusion / Q000009:adverse effects / Q000295:instrumentation* / Q000592:standards
keywords: Anterior cervical discectomy and fusion; Cervical degenerative disc disease; Cervical spine; Plate and cage; Zero-p