title: Evolution of Clinical and Electrophysiological Data in Children with a Preexcitation Syndrome.
abstract: BACKGROUND
  With ablation, the follow-up of preexcitation syndrome now is difficult to assess. The purpose was to collect data of children with a preexcitation syndrome studied on two separate occasions within a minimal interval of 1 year.
  
  
  METHODS
  This is a retrospective chart review of 47 children initially aged 12 ± 4 years, who underwent two or more invasive electrophysiological studies (EPS) within 1-25 years of one another (6.3 ± 4.8) for occurrence of symptoms or new evaluation.
  
  
  RESULTS
  Among initially symptomatic children (n = 25), four (19%) became asymptomatic and one presented life-threatening arrhythmia. Among asymptomatic children (n = 22), five became symptomatic (22.7%). Anterograde conduction disappeared in seven of 23 children with initially long accessory pathway-effective refractory period, but four of six had still induced atrioventricular reentrant tachycardia (AVRT). AVRT was induced at second EPS in three of 13 asymptomatic preexcitation syndrome with negative initial EPS. There were no spontaneous adverse events in the five children with criteria of malignancy at initial EPS; signs of malignancy disappeared in two. At multivariate analysis, AVRT at initial EPS was the only independent factor of symptomatic AVRT during follow-up. Absence of induced AVRT at initial EPS was the only factor of absence of symptoms and a negative study at the second EPS.
  
  
  CONCLUSIONS
  There were no significant changes of data in children after 6.3 ± 4.8 years of follow-up. Most children with spontaneous/inducible AVRTs at initial EPS had still inducible AVRT at second EPS. Induced AF conducted with high rate has a relatively low prognostic value for the prediction of adverse events.
authors.affiliation: Adult and Paediatric Cardiology, CHU de Brabois, Vandoeuvre Les Nancy, France. bbrembilla@gmail.com.
authors.forename: Béatrice
authors.initials: B
authors.lastname: Brembilla-Perrot
authors.affiliation: Adult and Paediatric Cardiology, CHU de Brabois, Vandoeuvre Les Nancy, France.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Sellal
authors.affiliation: Adult and Paediatric Cardiology, CHU de Brabois, Vandoeuvre Les Nancy, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Olivier
authors.affiliation: Adult and Paediatric Cardiology, CHU de Brabois, Vandoeuvre Les Nancy, France.
authors.forename: Thibaut
authors.initials: T
authors.lastname: Villemin
authors.affiliation: Adult and Paediatric Cardiology, CHU de Brabois, Vandoeuvre Les Nancy, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Moulin-Zinsch
authors.affiliation: Adult and Paediatric Cardiology, CHU de Brabois, Vandoeuvre Les Nancy, France.
authors.forename: Daniel
authors.initials: D
authors.lastname: Beurrier
authors.affiliation: Adult and Paediatric Cardiology, CHU de Brabois, Vandoeuvre Les Nancy, France.
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Lethor
authors.affiliation: Adult and Paediatric Cardiology, CHU de Brabois, Vandoeuvre Les Nancy, France.
authors.forename: François
authors.initials: F
authors.lastname: Marçon
authors.affiliation: Adult and Paediatric Cardiology, CHU de Brabois, Vandoeuvre Les Nancy, France.
authors.forename: Christian
authors.initials: C
authors.lastname: DE Chillou
authors.affiliation: CIC IT, CHU de Brabois, Vandoeuvre Les Nancy, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Felblinger
authors.affiliation: Adult and Paediatric Cardiology, CHU de Brabois, Vandoeuvre Les Nancy, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Vincent
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D000067576:Child Health; D002675:Child, Preschool; D018450:Disease Progression; D004562:Electrocardiography / Q000379:methods*; D005260:Female; D006801:Humans; D007223:Infant; D008137:Longitudinal Studies; D008297:Male; D011226:Pre-Excitation Syndromes / Q000175:diagnosis*; D063189:Symptom Assessment / Q000379:methods*; D055815:Young Adult
keywords: Wolff-Parkinson-White syndrome; children; electrophysiologic study; follow-up