title: Magnetic resonance imaging based noninvasive measurements of brain hemodynamics in neonates: a review.
abstract: Perinatal disturbances of brain hemodynamics can have a detrimental effect on the brain's parenchyma with consequently adverse neurodevelopmental outcome. Noninvasive, reliable tools to evaluate the neonate's brain hemodynamics are scarce. Advances in magnetic resonance imaging have provided new methods to noninvasively assess brain hemodynamics. More recently these methods have made their transition to the neonatal population. The aim of this review is twofold. Firstly, to describe these newly available noninvasive methods to investigate brain hemodynamics in neonates. Secondly, to discuss the results that were obtained with these techniques, identifying both potential clinical applications as well as gaps of knowledge.
authors.affiliation: Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Jill B
authors.initials: JB
authors.lastname: De Vis
authors.affiliation: Department of Neonatology, Wilhelmina's Children's hospital/University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Thomas
authors.initials: T
authors.lastname: Alderliesten
authors.affiliation: Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Jeroen
authors.initials: J
authors.lastname: Hendrikse
authors.affiliation: Department of Neonatology, Wilhelmina's Children's hospital/University Medical Center Utrecht, Utrecht, The Netherlands.|Danish Research Center for MR, Hidovre Hospital, Copenhagen, Denmark.
authors.forename: Esben T
authors.initials: ET
authors.lastname: Petersen
authors.affiliation: Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Manon J N L
authors.initials: MJ
authors.lastname: Benders
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D002545:Brain Ischemia / Q000000981:diagnostic imaging / Q000473:pathology; D002560:Cerebrovascular Circulation; D006439:Hemodynamics; D006801:Humans; D000860:Hypoxia / Q000000981:diagnostic imaging / Q000473:pathology; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D064847:Multimodal Imaging; D065886:Neurodevelopmental Disorders / Q000000981:diagnostic imaging / Q000473:pathology; D010100:Oxygen / Q000737:chemistry
chemical_list: D010100:Oxygen