title: Depth-resolved analytical model and correction algorithm for photothermal optical coherence tomography.
abstract: Photothermal OCT (PT-OCT) is an emerging molecular imaging technique that occupies a spatial imaging regime between microscopy and whole body imaging. PT-OCT would benefit from a theoretical model to optimize imaging parameters and test image processing algorithms. We propose the first analytical PT-OCT model to replicate an experimental A-scan in homogeneous and layered samples. We also propose the PT-CLEAN algorithm to reduce phase-accumulation and shadowing, two artifacts found in PT-OCT images, and demonstrate it on phantoms and in vivo mouse tumors.
authors.affiliation: Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA.
authors.forename: Maryse
authors.initials: M
authors.lastname: Lapierre-Landry
authors.affiliation: Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA.
authors.forename: Jason M
authors.initials: JM
authors.lastname: Tucker-Schwartz
authors.affiliation: Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA.
authors.forename: Melissa C
authors.initials: MC
authors.lastname: Skala
keywords: (110.4500) Optical coherence tomography; (350.5340) Photothermal effects