title: Voxel-based morphometry reveals brain gray matter volume changes in successful dieters.
abstract: To compare regional brain volume predictors of percent weight loss (WL) in dieters with obesity (DwO) and in the same participants categorized as "successful" (≥7% WL) or "unsuccessful" dieters (<7% WL).
  
  
  
  DwO (n = 72) and participants with healthy weight (n = 22) completed a structural MRI at baseline and 3 months. All DwO participants were enrolled in a 12-week program consisting of a reduced calorie diet, increased physical activity, and behavioral modification. SPM8-based voxel-based morphometry processing streams were used for measurements of regional gray (GMV) and white matter volume and longitudinal changes in volume. Correlations between WL and baseline brain volume and change in brain volume, as well as differences between groups, were then tested.
  
  
  
  %WL was positively correlated with baseline GMV in right parahippocampal and orbitofrontal gyri in DwO. Successful dieters showed greater GMV loss in the left precentral gyrus and the insula compared with unsuccessful dieters. A negative correlation was found between %WL and GMV change from baseline in the left prefrontal regions.
  
  
  
  Findings illustrate that WL is related to volumetric changes in brain areas previously linked to interoception and food motivation.
authors.affiliation: Department of Neurology, University of Kansas School of Medicine, Kansas City, Kansas, USA.
authors.forename: Robyn A
authors.initials: RA
authors.lastname: Honea
authors.affiliation: Cardiovascular Research Institute, University of Kansas Medical Center, Kansas City, Kansas, USA.
authors.forename: Amanda N
authors.initials: AN
authors.lastname: Szabo-Reed
authors.affiliation: Department of Psychiatry, University of Kansas School of Medicine, Kansas City, Kansas, USA.
authors.forename: Rebecca J
authors.identifier: 0000-0001-9269-051X
authors.initials: RJ
authors.lastname: Lepping
authors.affiliation: Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Perea
authors.affiliation: Center for Health Behavior Neuroscience, University of Kansas Medical Center, Kansas City, Kansas, USA.
authors.forename: Florence
authors.initials: F
authors.lastname: Breslin
authors.affiliation: Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, Kansas, USA.|Department of Preventive Medicine and Public Health, University of Kansas Medical Center, Kansas City, Kansas, USA.
authors.forename: Laura E
authors.initials: LE
authors.lastname: Martin
authors.affiliation: Department of Neurology, University of Kansas School of Medicine, Kansas City, Kansas, USA.|Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, Kansas, USA.|Department of Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, USA.
authors.forename: William M
authors.initials: WM
authors.lastname: Brooks
authors.affiliation: Cardiovascular Research Institute, University of Kansas Medical Center, Kansas City, Kansas, USA.
authors.forename: Joseph E
authors.initials: JE
authors.lastname: Donnelly
authors.affiliation: Center for Health Behavior Neuroscience, University of Kansas Medical Center, Kansas City, Kansas, USA.
authors.forename: Cary R
authors.initials: CR
authors.lastname: Savage
mesh_terms: D000328:Adult; D001521:Behavior Therapy; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D031204:Caloric Restriction; D004038:Diet, Reducing; D015444:Exercise; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000473:pathology; D066128:Gray Matter / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000473:pathology / Q000628:therapy*; D015431:Weight Loss; D066127:White Matter / Q000000981:diagnostic imaging / Q000473:pathology