title: Angiotensin (1-7) and Alamandine: Similarities and differences.
abstract: A primary peptide of the renin angiotensin system (RAS), Angiotensin (Ang) II, is a vasoconstrictor and promotor of atherosclerosis. To counter this, the RAS also consists of peptides and receptors which increase nitric oxide release from the endothelium and decrease nicotinamide adenine dinucleotide phosphate oxidase-related superoxide production. Two peptides, Ang (1-7) and alamandine are vasodilators, by activating the nitric oxide pathway via different receptors in the endothelium. Thus, herein we focus on the similarities and differences between alamandine and Ang (1-7) and the counterbalancing hypothesis on Ang II during endothelial dysfunction and atherosclerosis.
authors.affiliation: Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, Werribee Campus, 3030 Victoria, Australia. Electronic address: tawar.qaradakhi@live.vu.edu.au.
authors.forename: Tawar
authors.initials: T
authors.lastname: Qaradakhi
authors.affiliation: Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, Werribee Campus, 3030 Victoria, Australia.
authors.forename: Vasso
authors.initials: V
authors.lastname: Apostolopoulos
authors.affiliation: Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, Werribee Campus, 3030 Victoria, Australia.
authors.forename: Anthony
authors.initials: A
authors.lastname: Zulli
mesh_terms: D000803:Angiotensin I / Q000494:pharmacology*; D000818:Animals; D050197:Atherosclerosis / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism; D009842:Oligopeptides / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology*; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000819:agonists / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000819:agonists / Q000378:metabolism; D012084:Renin-Angiotensin System / Q000187:drug effects*; D015398:Signal Transduction / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: C000591482:MRGPRD protein, human; D009842:Oligopeptides; D010446:Peptide Fragments; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D043562:Receptors, G-Protein-Coupled; D014665:Vasodilator Agents; C581752:alamandine; D009569:Nitric Oxide; D000803:Angiotensin I; C118790:angiotensin I (1-7)
keywords: Alamandine; Alamandine (44192273); Angiotensin (1-7); Angiotensin 1-7 (123805); Angiotensin I (3081372); Angiotensin II (172198); Endothelial dysfunction; Renin angiotensin system