title: Altered brain functional networks in people with Internet gaming disorder: Evidence from resting-state fMRI.
abstract: Although numerous neuroimaging studies have detected structural and functional abnormality in specific brain regions and connections in subjects with Internet gaming disorder (IGD), the topological organization of the whole-brain network in IGD remain unclear. In this study, we applied graph theoretical analysis to explore the intrinsic topological properties of brain networks in Internet gaming disorder (IGD). 37 IGD subjects and 35 matched healthy control (HC) subjects underwent a resting-state functional magnetic resonance imaging scan. The functional networks were constructed by thresholding partial correlation matrices of 90 brain regions. Then we applied graph-based approaches to analysis their topological attributes, including small-worldness, nodal metrics, and efficiency. Both IGD and HC subjects show efficient and economic brain network, and small-world topology. Although there was no significant group difference in global topology metrics, the IGD subjects showed reduced regional centralities in the prefrontal cortex, left posterior cingulate cortex, right amygdala, and bilateral lingual gyrus, and increased functional connectivity in sensory-motor-related brain networks compared to the HC subjects. These results imply that people with IGD may be associated with functional network dysfunction, including impaired executive control and emotional management, but enhanced coordination among visual, sensorimotor, auditory and visuospatial systems.
authors.affiliation: Department of Psychology, Zhejiang Normal University, Jinhua, China.
authors.forename: Lingxiao
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Psychology, University of Konstanz, Konstanz, Germany.
authors.forename: Lingdan
authors.initials: L
authors.lastname: Wu
authors.affiliation: Center for Life Science, Peking University, Beijing, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Lin
authors.affiliation: Department of Psychology, Zhejiang Normal University, Jinhua, China.
authors.forename: Yifen
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Psychology, Zhejiang Normal University, Jinhua, China.
authors.forename: Hongli
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Department of Physics, Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China.
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Du
authors.affiliation: Department of Psychology, Zhejiang Normal University, Jinhua, China. Electronic address: dongguangheng@zjnu.edu.cn.
authors.forename: Guangheng
authors.initials: G
authors.lastname: Dong
mesh_terms: D000679:Amygdala / Q000000981:diagnostic imaging / Q000503:physiopathology; D016739:Behavior, Addictive / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001921:Brain / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001931:Brain Mapping; D016022:Case-Control Studies; D056344:Executive Function; D059907:Functional Neuroimaging; D006179:Gyrus Cinguli / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D020407:Internet; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000503:physiopathology; D009778:Occipital Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging / Q000503:physiopathology; D018910:Video Games; D055815:Young Adult
keywords: Emotional management; Executive control; Internet gaming disorder; Small-world