title: A new method of infrared thermography for quantification of brown adipose tissue activation in healthy adults (TACTICAL): a randomized trial.
abstract: The ability to alter the amount and activity of brown adipose tissue (BAT) in human adults is a potential strategy to manage obesity and related metabolic disorders associated with food, drug, and environmental stimuli with BAT activating/recruiting capacity. Infrared thermography (IRT) provides a non-invasive and inexpensive alternative to the current methods (e.g.18F-FDG PET) used to assess BAT. We have quantified BAT activation in the cervical-supraclavicular (C-SCV) region using IRT video imaging and a novel image computational algorithm by studying C-SCV heat production in healthy young men after cold stimulation and the ingestion of capsinoids in a prospective double-blind placebo-controlled randomized trial. Subjects were divided into low-BAT and high-BAT groups based on changes in IR emissions in the C-SCV region induced by cold. The high-BAT group showed significant increases in energy expenditure, fat oxidation, and heat output in the C-SCV region post-capsinoid ingestion compared to post-placebo ingestion, but the low-BAT group did not. Based on these results, we conclude that IRT is a promising tool for quantifying BAT activity.
authors.affiliation: Clinical Nutrition Research Centre, Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.
authors.forename: Qi Yan
authors.initials: QY
authors.lastname: Ang
authors.affiliation: Clinical Nutrition Research Centre, Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.
authors.forename: Hui Jen
authors.initials: HJ
authors.lastname: Goh
authors.affiliation: Institute for Infocomm Research, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.
authors.forename: Yanpeng
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Institute for Infocomm Research, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.
authors.forename: Yiqun
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore.|School of Engineering and Mathematical Sciences, La Trobe University, Melbourne, Australia.
authors.forename: Siew-Pang
authors.initials: SP
authors.lastname: Chan
authors.affiliation: Clinical Nutrition Research Centre, Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.|Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore.
authors.forename: Judith L
authors.initials: JL
authors.lastname: Swain
authors.affiliation: Clinical Nutrition Research Centre, Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.|Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore.
authors.forename: Christiani Jeyakumar
authors.initials: CJ
authors.lastname: Henry
authors.affiliation: Clinical Nutrition Research Centre, Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore. melvin_leow@sics.a-star.edu.sg.|Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore. melvin_leow@sics.a-star.edu.sg.|Department of Endocrinology, Tan Tock Seng Hospital, Singapore, Singapore. melvin_leow@sics.a-star.edu.sg.|Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Republic of Singapore. melvin_leow@sics.a-star.edu.sg.|Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore, Republic of Singapore. melvin_leow@sics.a-star.edu.sg.
authors.forename: Melvin Khee-Shing
authors.initials: MK
authors.lastname: Leow
mesh_terms: D002001:Adipose Tissue, Brown / Q000502:physiology*; D000328:Adult; D004311:Double-Blind Method; D004734:Energy Metabolism / Q000502:physiology; D019788:Fluorodeoxyglucose F18 / Q000008:administration & dosage; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D009765:Obesity / Q000503:physiopathology; D010084:Oxidation-Reduction; D011446:Prospective Studies; D012881:Skin Temperature / Q000502:physiology; D013055:Spectrophotometry, Infrared / Q000379:methods; D022722:Thermogenesis / Q000502:physiology; D013817:Thermography / Q000379:methods; D055815:Young Adult
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: Brown adipose tissue; Capsinoids; Cold challenge; Infrared thermography; Supraclavicular skin temperature