title: New hybrid magnetic nanoparticles based on chitosan-maltose derivative for antitumor drug delivery.
abstract: The aim of the present study is to obtain, for the first time, polymer magnetic nanoparticles based on the chitosan-maltose derivative and magnetite. By chemically modifying the chitosan, its solubility in aqueous media was improved, which in turn facilitates the nanoparticles' preparation. Resulting polymers exhibit enhanced hydrophilia, which is an important factor in increasing the retention time of nanoparticles in the blood flow. The preparation of nanoparticles relied on the double crosslinking technique (ionic and covalent) in reverse emulsion which ensures the mechanical stability of the polymer carrier. The characterization of both the chitosan derivative and nanoparticles was accomplished by Fourier Transform Infrared Spectroscopy, Nuclear Magnetic Resonance Spectroscopy, Scanning Electron Microscopy, Transmission Electron Microscopy, Atomic Force Microscopy, Vibrating Sample Magnetometry, and Thermogravimetric Analysis. The evaluation of morphological, dimensional, structural, and magnetical properties, as well as thermal stability and swelling behavior of nanoparticles was made from the point of view of the polymer/magnetite ratio. The study of 5-Fluorouracil loading and release kinetics as well as evaluating the cytotoxicity and hemocompatibility of nanoparticles justify their adequate behavior in their potential use as devices for targeted transport of antitumor drugs.
authors.affiliation: Technical University "Gheorghe Asachi", Faculty of Chemical Engineering and Protection of the Environment, Department of Natural and Synthetic Polymers, 73, Bd. Professor dr. docent Dimitrie Mangeron, 700050 Iasi, Romania.
authors.forename: Liana
authors.initials: L
authors.lastname: Alupei
authors.affiliation: Technical University "Gheorghe Asachi", Faculty of Chemical Engineering and Protection of the Environment, Department of Natural and Synthetic Polymers, 73, Bd. Professor dr. docent Dimitrie Mangeron, 700050 Iasi, Romania.
authors.forename: Catalina Anisoara
authors.initials: CA
authors.lastname: Peptu
authors.affiliation: Purolite SRL, Research & Development Department, Aleea Uzinei Street, No. 11, Victoria, Brasov, Romania.
authors.forename: Andreea-Maria
authors.initials: AM
authors.lastname: Lungan
authors.affiliation: Pau et Pays de l'Adour University, IPREM (UMR CNRS 5254), Helioparc Pau Pyrénées, 64053 PAU Cedex 09, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Desbrieres
authors.affiliation: Alexandru Ioan Cuza University, Department of Physics, Iasi 700506, Romania.
authors.forename: Ovidiu
authors.initials: O
authors.lastname: Chiscan
authors.affiliation: Pau et Pays de l'Adour University, IPREM (UMR CNRS 5254), Helioparc Pau Pyrénées, 64053 PAU Cedex 09, France.
authors.forename: Sadia
authors.initials: S
authors.lastname: Radji
authors.affiliation: Technical University "Gheorghe Asachi", Faculty of Chemical Engineering and Protection of the Environment, Department of Natural and Synthetic Polymers, 73, Bd. Professor dr. docent Dimitrie Mangeron, 700050 Iasi, Romania; The Academy of Romanian Scientists, Bd. Independentei, 54, Sector 5, Bucuresti 50085, Romania. Electronic address: marpopa2001@yahoo.fr.
authors.forename: Marcel
authors.initials: M
authors.lastname: Popa
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D048271:Chitosan / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D005472:Fluorouracil / Q000494:pharmacology; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D007700:Kinetics; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D008320:Maltose / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D066244:Proton Magnetic Resonance Spectroscopy; D011817:Rabbits; D017550:Spectroscopy, Fourier Transform Infrared; D013535:Suspensions; D013696:Temperature; D013818:Thermogravimetry
chemical_list: D000970:Antineoplastic Agents; D058185:Magnetite Nanoparticles; D013535:Suspensions; D008320:Maltose; D048271:Chitosan; D005472:Fluorouracil
keywords: 5-Fluorouracil; Chitosan; Magnetite; Maltose; Nanoparticle