title: Synthesis of Oligodeoxynucleotides Containing Electrophilic Groups.
abstract: By use of 1,3-dithian-2-yl-methoxycarbonyl (Dmoc) as a protecting group and linker for oligodeoxynucleotide (ODN) synthesis, deprotection and cleavage are achieved under non-nucleophilic oxidative conditions. The nucleophile-sensitive thioester and α-chloroacetyl groups are conveniently incorporated into ODN sequences. The technology could be universally useful for electrophilic ODN synthesis.
authors.affiliation: Department of Chemistry, Michigan Technological University , 1400 Townsend Drive, Houghton, Michigan 49931, United States.
authors.forename: Xi
authors.initials: X
authors.lastname: Lin
authors.affiliation: Department of Chemistry, Michigan Technological University , 1400 Townsend Drive, Houghton, Michigan 49931, United States.
authors.forename: Jinsen
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Chemistry, Michigan Technological University , 1400 Townsend Drive, Houghton, Michigan 49931, United States.
authors.forename: Shahien
authors.initials: S
authors.lastname: Shahsavari
authors.affiliation: Department of Chemistry, Michigan Technological University , 1400 Townsend Drive, Houghton, Michigan 49931, United States.
authors.forename: Nathanael
authors.initials: N
authors.lastname: Green
authors.affiliation: Department of Chemistry, Michigan Technological University , 1400 Townsend Drive, Houghton, Michigan 49931, United States.
authors.forename: Deepti
authors.initials: D
authors.lastname: Goyal
authors.affiliation: Department of Chemistry, Michigan Technological University , 1400 Townsend Drive, Houghton, Michigan 49931, United States.
authors.forename: Shiyue
authors.initials: S
authors.lastname: Fang
mesh_terms: D008968:Molecular Conformation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D009838:Oligodeoxyribonucleotides