title: DNA Scaffolds for the Dictated Assembly of Left-/Right-Handed Plasmonic Au NP Helices with Programmed Chiro-Optical Properties.
abstract: Within the broad interest of assembling chiral left- and right-handed helices of plasmonic nanoparticles (NPs), we introduce the DNA-guided organization of left- or right-handed plasmonic Au NPs on DNA scaffolds. The method involves the self-assembly of stacked 12 DNA quasi-rings interlinked by 30 staple-strands. By the functionalization of one group of staple units with programmed tether-nucleic acid strands and additional staple elements with long nucleic acid chains, acting as promoter strands, the promoter-guided assembly of barrels modified with 12 left- or right-handed tethers is achieved. The subsequent hybridization of Au NPs functionalized with single nucleic acid tethers yields left- or right-handed structures of plasmonic NPs. The plasmonic NP structures reveal CD spectra at the plasmon absorbance, and the NPs are imaged by HR-TEM. Using geometrical considerations corresponding to the left- and right-handed helices of the Au NPs, the experimental CD spectra of the plasmonic Au NPs are modeled by theoretical calculations.
authors.affiliation: The Institute of Chemistry, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem , Jerusalem 91904, Israel.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Cecconello
authors.affiliation: The Institute of Chemistry, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem , Jerusalem 91904, Israel.
authors.forename: Jason S
authors.initials: JS
authors.lastname: Kahn
authors.affiliation: The Institute of Chemistry, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem , Jerusalem 91904, Israel.
authors.forename: Chun-Hua
authors.initials: CH
authors.lastname: Lu
authors.affiliation: Department of Physics and Astronomy, Ohio University , Athens, Ohio 45701, United States.
authors.forename: Larousse
authors.initials: L
authors.lastname: Khosravi Khorashad
authors.affiliation: Department of Physics and Astronomy, Ohio University , Athens, Ohio 45701, United States.
authors.forename: Alexander O
authors.initials: AO
authors.lastname: Govorov
authors.affiliation: The Institute of Chemistry, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem , Jerusalem 91904, Israel.
authors.forename: Itamar
authors.initials: I
authors.lastname: Willner
mesh_terms: D015374:Biosensing Techniques; D002942:Circular Dichroism; D003198:Computer Simulation; D004247:DNA / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D046529:Microscopy, Electron, Transmission; D009693:Nucleic Acid Hybridization; D055095:Optics and Photonics; D013237:Stereoisomerism; D013696:Temperature
chemical_list: D006046:Gold; D004247:DNA