title: Mean arterial pressure change associated with cerebral blood flow in healthy older adults.
abstract: We investigate over a 12-year period the association between regional cerebral blood flow (CBF) and cardiovascular risk factors in a prospective cohort of healthy older adults (81.96 ± 3.82 year-old) from the Cognitive REServe and Clinical ENDOphenotype (CRESCENDO) study. Cardiovascular risk factors were measured over 12 years, and gray matter CBF was measured at the end of the study from high-resolution magnetic resonance imaging using arterial spin labeling. The association between cardiovascular risk factors, their long-term change, and CBF was assessed using multivariate linear regression models. Women were observed to have higher CBF than men (p < 0.05). Increased mean arterial pressure (MAP) over the 12-year period was correlated with a low cerebral blood flow (p < 0.05, R(2) = 0.21), whereas no association was detected between CBF and MAP at the time of imaging. High levels of glycemia tended to be associated with low cerebral blood flow values (p < 0.05). Age, alcohol consumption, smoking status, body mass index, history of cardiovascular disease, and hypertension were not associated with CBF. Our main result suggests that change in MAP is the most significant predictor of future CBF in older adults.
authors.affiliation: Laboratoire Charles Coulomb, CNRS UMR 5221, Université Montpellier II, Montpellier, France; Intrasense, Montpellier, Hérault, France; Department of Neuroradiology, Institut d'Imagerie Fonctionnelle Humaine, I2FH, University Hospital Center, Gui de Chauliac Hospital, Montpellier, France; Institut de Génomique Fonctionnelle, UMR 5203, INSERM U661, Université Montpellier II, Université Montpellier I, France. Electronic address: jeremy.deverdun@neuf.fr.
authors.forename: Jeremy
authors.initials: J
authors.lastname: Deverdun
authors.affiliation: Inserm U 1198, Montpellier, France; University Montpellier, Montpellier, France; EPHE, Paris, France; Department of Epidemiology and Public Health, University College London, London, UK; Inserm U 710, Montpellier, France.
authors.forename: Tasnime N
authors.initials: TN
authors.lastname: Akbaraly
authors.affiliation: Department of Neuroradiology, Institut d'Imagerie Fonctionnelle Humaine, I2FH, University Hospital Center, Gui de Chauliac Hospital, Montpellier, France; Inserm U 1061, Montpellier, France.
authors.forename: Celine
authors.initials: C
authors.lastname: Charroud
authors.affiliation: Inserm U 1061, Montpellier, France; Université Montpellier I, Montpellier, France.
authors.forename: Meriem
authors.initials: M
authors.lastname: Abdennour
authors.affiliation: Cognitive Neuroscience Division, Department of Neurology, Columbia University, New York, USA.
authors.forename: Adam M
authors.initials: AM
authors.lastname: Brickman
authors.affiliation: Intrasense, Montpellier, Hérault, France.
authors.forename: Stephane
authors.initials: S
authors.lastname: Chemouny
authors.affiliation: Cognitive Neuroscience Division, Department of Neurology, Columbia University, New York, USA.
authors.forename: Jason
authors.initials: J
authors.lastname: Steffener
authors.affiliation: Inserm U 1061, Montpellier, France; Université Montpellier I, Montpellier, France; Montpellier University Hospital, University Department of Adult Psychiatry, La Colombière Hospital, Montpellier, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Portet
authors.affiliation: Department of Neuroradiology, Institut d'Imagerie Fonctionnelle Humaine, I2FH, University Hospital Center, Gui de Chauliac Hospital, Montpellier, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Bonafe
authors.affiliation: Cognitive Neuroscience Division, Department of Neurology, Columbia University, New York, USA.
authors.forename: Yaakov
authors.initials: Y
authors.lastname: Stern
authors.affiliation: Inserm U 1061, Montpellier, France; Université Montpellier I, Montpellier, France; Faculty of Medicine, Imperial College, London, England.
authors.forename: Karen
authors.initials: K
authors.lastname: Ritchie
authors.affiliation: Laboratoire Charles Coulomb, CNRS UMR 5221, Université Montpellier II, Montpellier, France; Department of Neuroradiology, Institut d'Imagerie Fonctionnelle Humaine, I2FH, University Hospital Center, Gui de Chauliac Hospital, Montpellier, France; Institut de Génomique Fonctionnelle, UMR 5203, INSERM U661, Université Montpellier II, Université Montpellier I, France.
authors.forename: François
authors.initials: F
authors.lastname: Molino
authors.affiliation: Department of Neuroradiology, Institut d'Imagerie Fonctionnelle Humaine, I2FH, University Hospital Center, Gui de Chauliac Hospital, Montpellier, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Le Bars
authors.affiliation: Department of Neuroradiology, Institut d'Imagerie Fonctionnelle Humaine, I2FH, University Hospital Center, Gui de Chauliac Hospital, Montpellier, France; Team "Plasticity of Central Nervous System, Stem Cells and Glial Tumors", U1051, Institut of Neurosciences of Montpellier, Saint Eloi Hospital, Montpellier, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Menjot de Champfleur
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D062186:Arterial Pressure / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000209:etiology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D015331:Cohort Studies; D005260:Female; D005544:Forecasting; D038321:Glycemic Index / Q000502:physiology; D066128:Gray Matter / Q000098:blood supply / Q000000981:diagnostic imaging; D006801:Humans; D016014:Linear Models; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D011446:Prospective Studies; D012307:Risk Factors; D012727:Sex Characteristics; D013997:Time Factors
keywords: Aging; Arterial spin labelling; Cerebral blood flow; Hypertension; Magnetic resonance imaging