title: Plasma levels of adipokines in systemic lupus erythematosus patients.
abstract: To evaluate the plasma levels of six adipokines, including chemerin, omentin-1, lipocalin-2, cathepsin-S, cathepsin-L and adipsin, in patients with SLE.
  
  
  
  Ninety SLE patients and ninety control subjects were recruited, plasma adipokines levels were measured by enzyme-linked immunosorbent assay, and their associations with major clinical and laboratory indexes were analyzed.
  
  
  
  There were no significant differences in plasma chemerin, omentin-1, lipocalin-2, cathepsin-S, cathepsin-L and adipsin levels between SLE patients and controls. Further subgroup analyses by major clinical and laboratory indexes showed that plasma omentin-1 level was significantly lower in SLE patients without nephritis when compared with those patients with nephritis (P=0.002). Plasma chemerin, cathepsin-S levels in SLE patients without nervous system disorder were significantly lower in comparison with SLE patients with nervous system disorder (P=0.035, P=0.029). No significant associations of other adipokines with any major clinical and laboratory indexes were observed.
  
  
  
  Plasma levels of chemerin, omentin-1, lipocalin-2, cathepsin-S, cathepsin-L and adipsin in SLE patients were not markedly different from the normal controls. The presence of nephritis was connected with higher plasma omentin-1 levels in SLE patients, and the presence of nervous system disorder was associated with higher plasma chemerin, cathepsin-S levels in SLE patients. However, functional studies are awaited to further explore the potential roles of these cytokines in SLE.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China; Anhui Provincial Laboratory of Population Health & Major Disease Screening and Diagnosis, Hefei, China.
authors.forename: Tian-Ping
authors.initials: TP
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China; Anhui Provincial Laboratory of Population Health & Major Disease Screening and Diagnosis, Hefei, China.
authors.forename: Hong-Miao
authors.initials: HM
authors.lastname: Li
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China; Anhui Provincial Laboratory of Population Health & Major Disease Screening and Diagnosis, Hefei, China.
authors.forename: Rui-Xue
authors.initials: RX
authors.lastname: Leng
authors.affiliation: Department of Rheumatology, Anhui Provincial Hospital, Hefei, China.
authors.forename: Xiang-Pei
authors.initials: XP
authors.lastname: Li
authors.affiliation: Department of Rheumatology, Anhui Provincial Hospital, Hefei, China.
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Li
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China; Anhui Provincial Laboratory of Population Health & Major Disease Screening and Diagnosis, Hefei, China. Electronic address: panhaifeng1982@sina.com.
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Pan
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China; Anhui Provincial Laboratory of Population Health & Major Disease Screening and Diagnosis, Hefei, China. Electronic address: ydqahmu@gmail.com.
authors.forename: Dong-Qing
authors.initials: DQ
authors.lastname: Ye
mesh_terms: D054392:Adipokines / Q000097:blood*; D000328:Adult; D002403:Cathepsins / Q000097:blood; D011416:Complement Factor D / Q000032:analysis; D016207:Cytokines / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D058851:GPI-Linked Proteins / Q000097:blood; D006801:Humans; D037102:Lectins / Q000097:blood; D000071068:Lipocalin-2 / Q000097:blood; D008180:Lupus Erythematosus, Systemic / Q000097:blood*; D008181:Lupus Nephritis / Q000097:blood; D008875:Middle Aged; D009422:Nervous System Diseases / Q000097:blood; D055815:Young Adult
chemical_list: D054392:Adipokines; D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins; D000071068:Lipocalin-2; D002403:Cathepsins; D011416:Complement Factor D; C028217:cathepsin S
keywords: Adipokines; Lupus nephritis; Systemic lupus erythematosus