title: [COMPARATIVE CEREBROPROTECTIVE EFFECT OF PREVENTIVE ADMINISTRATION OF MAGNESIUM HYDROXYBUTYRATE VERSUS MAGNESIUM SULFATE AND CAVINTON IN RATS WITH COMMON CAROTID ARTERY OCCLUSION].
abstract: Dose-dependent cerebroprotective effect of magnesium hydroxybutyrate (MHB) on common carotid artery occlusion model in rats was established. Administration of 150 mg/kg MHB led to significant decrease in animal mortality (up to 9.3 times) in comparison to control (p < 0.05). This MHB dose also produced significant decrease of neurological deficit on the McGraw scale in comparison to control and magnesium sulfate (50% and 20%, respectively). The MHB treated animals also showed improved locomotor and exploratory performance in the open-field test and retained memory performance in the passive avoidance test and extrapolation escape task test. The administration of 150 mg/kg MHB produced three-fold (p < 0.05) decrease of brain edema in animals with cerebral blood flow impairment in comparison to animals treated with magnesium sulfate and cavinton.
authors.forename: I N
authors.initials: IN
authors.lastname: Tyurenkov
authors.forename: A A
authors.initials: AA
authors.lastname: Litvinov
authors.forename: D V
authors.initials: DV
authors.lastname: Kurkin
authors.forename: E V
authors.initials: EV
authors.lastname: Volotova
authors.forename: A P
authors.initials: AP
authors.lastname: Darmanyan
authors.forename: A A
authors.initials: AA
authors.lastname: Ozerov
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001929:Brain Edema / Q000401:mortality / Q000473:pathology / Q000517:prevention & control*; D002545:Brain Ischemia / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D017536:Carotid Artery, Common / Q000601:surgery; D002560:Cerebrovascular Circulation / Q000187:drug effects; D054059:Coronary Occlusion / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D006885:Hydroxybutyrates; D008274:Magnesium / Q000494:pharmacology*; D008278:Magnesium Sulfate / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D018696:Neuroprotective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D016019:Survival Analysis; D014748:Vinca Alkaloids / Q000494:pharmacology*
chemical_list: D006885:Hydroxybutyrates; D018696:Neuroprotective Agents; D014748:Vinca Alkaloids; C013983:vinpocetine; D008278:Magnesium Sulfate; D008274:Magnesium