title: Design and Synthesis of 2,2'-Diindolylmethanes to Selectively Target Certain G-Quadruplex DNA Structures.
abstract: G-quadruplex (G4) structures carry vital biological functions, and compounds that selectively target certain G4 structures have both therapeutic potential and value as research tools. Along this line, 2,2'-diindolylmethanes have been designed and synthesized in this work based on the condensation of 3,6- or 3,7-disubstituted indoles with aldehydes. The developed class of compounds efficiently stabilizes G4 structures without inducing conformational changes in such structures. Furthermore, the 2,2'-diindolylmethanes target certain G4 structures more efficiently than others and this G4 selectivity can be altered by chemical modifications of the compounds.
authors.affiliation: Department of Chemistry, Umeå University, 901 87, Umeå, Sweden.
authors.forename: Madeleine
authors.identifier: http://orcid.org/0000-0002-5890-9271
authors.initials: M
authors.lastname: Livendahl
authors.affiliation: Department of Medical Biochemistry and Biophysics, Umeå University, 901 87, Umeå, Sweden.
authors.forename: Jan
authors.identifier: http://orcid.org/0000-0001-6871-7663
authors.initials: J
authors.lastname: Jamroskovic
authors.affiliation: Department of Chemistry, Umeå University, 901 87, Umeå, Sweden.
authors.forename: Svetlana
authors.initials: S
authors.lastname: Ivanova
authors.affiliation: Department of Chemistry, Umeå University, 901 87, Umeå, Sweden.
authors.forename: Peter
authors.initials: P
authors.lastname: Demirel
authors.affiliation: Department of Medical Biochemistry and Biophysics, Umeå University, 901 87, Umeå, Sweden. nasim.sabouri@umu.se.
authors.forename: Nasim
authors.identifier: http://orcid.org/0000-0002-4541-7702
authors.initials: N
authors.lastname: Sabouri
authors.affiliation: Department of Chemistry, Umeå University, 901 87, Umeå, Sweden. erik.chorell@umu.se.
authors.forename: Erik
authors.identifier: http://orcid.org/0000-0003-2523-1940
authors.initials: E
authors.lastname: Chorell
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D001665:Binding Sites; D004247:DNA / Q000737:chemistry*; D054856:G-Quadruplexes; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D013329:Structure-Activity Relationship
chemical_list: C017237:2,2'-diindolylmethane; D000447:Aldehydes; D007211:Indoles; D004247:DNA
keywords: G4 structure; indole derivatives; phen-DC3; quadruplex; selectivity