title: [Dosing regimens of antibiotics in neonates: Variations in clinical practice and what should be done?].
abstract: There is wide variation in neonatal dosages of antibiotics in clinical practice, both nationally and internationally. This reflects the lack of evaluation of drugs in this therapeutic class, although widely prescribed. Given this situation, optimization of antibiotic prescription is required to ensure efficacy and safety of neonatal treatment and reduce microbial resistance. Rational prescription should be based on the knowledge of developmental pharmacokinetics and pharmacodynamics. Rigorous studies, conducted in collaboration between neonatologists and pharmacologists, are essential to develop and validate evidence-based neonatal dosage regimens.
authors.affiliation: Service de pharmacologie pédiatrique et pharmacogénétique, hôpital Robert-Debré, 48, boulevard Sérurier, 75019 Paris, France; EA7323, université Paris Diderot, université Paris Descartes, 75019 Paris, France; Service de néonatologie et réanimation néonatale, CHU, hôpital Sud, 16, boulevard de Bulgarie, BP 90347, 35203 Rennes cedex, France.
authors.forename: S
authors.initials: S
authors.lastname: Leroux
authors.affiliation: Service de pharmacologie pédiatrique et pharmacogénétique, hôpital Robert-Debré, 48, boulevard Sérurier, 75019 Paris, France; EA7323, université Paris Diderot, université Paris Descartes, 75019 Paris, France; Centre d'investigation clinique CIC9202, Inserm, 75019 Paris, France.
authors.forename: W
authors.initials: W
authors.lastname: Zhao
authors.affiliation: EA7323, université Paris Diderot, université Paris Descartes, 75019 Paris, France; Service de néonatologie et réanimation néonatale, hôpital Robert-Debré, 48, boulevard Sérurier, 75019 Paris, France.
authors.forename: V
authors.initials: V
authors.lastname: Biran
authors.affiliation: Service de pharmacologie pédiatrique et pharmacogénétique, hôpital Robert-Debré, 48, boulevard Sérurier, 75019 Paris, France; EA7323, université Paris Diderot, université Paris Descartes, 75019 Paris, France; Centre d'investigation clinique CIC9202, Inserm, 75019 Paris, France. Electronic address: evelyne.jacqzaigrain@gmail.com.
authors.forename: E
authors.initials: E
authors.lastname: Jacqz-Aigrain
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007231:Infant, Newborn; D012014:Reference Books, Medical
chemical_list: D000900:Anti-Bacterial Agents