title: Investigation of biological effects of some Mannich Bases containing Bis-1,2,4- Triazole.
abstract: In this study, the effects of Mannich bases containing bis-1,2,4-triazole on the levels of in vivo malondialdehyde (MDA) and antioxidant vitamins (A, E, C) were examined in serum, livers and kidneys of rats. DA and vitamin (A, E, C) levels were determined by high performance liquid chromatography (HPLC). Antioxidant effect was investigated by determining the MDA levels in Saccharomyces cerevisiae cells as in vitro. Furthermore, the antitumor effects of compounds were investigated against MCF-7 human breast cancer cells. Interrelations of results among control and compound groups were evaluated using SPSS statistical software package. As a result, some of the compounds showed effective biological activity when compared to control conditions. The test compounds used in this study may be effective for utilization in the selection and design of model compounds for further studies.
authors.affiliation: Firat University Keban Vocational High School Elazig Turkey akifparlak23@gmail.com.
authors.forename: A E
authors.initials: AE
authors.lastname: Parlak
authors.affiliation: Usak University Faculty of Dentistry Usak Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Celik
authors.affiliation: Firat University, Faculty of Science Department of Chemistry Elazig Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Karatepe
authors.affiliation: Firat University Faculty of Health Sciences Elazig Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Turkoglu
authors.affiliation: Usak University Banaz Vocational High School Usak Turkey.
authors.forename: N O
authors.initials: NO
authors.lastname: Alayunt
authors.affiliation: Cumhuriyet University, Faculty of Veterinary Medicine Department of Biometrics and Genetics Sivas Turkey.
authors.forename: S D
authors.initials: SD
authors.lastname: Dastan
authors.affiliation: Firat University, Faculty of Medicine Department of Physiology Elazig Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Ulas
authors.affiliation: Inonu University, Faculty of Medicine Department of Physiology Malatya Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Sandal
authors.affiliation: Inonu University, Faculty of Medicine Department of Physiology Malatya Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Tekin
authors.affiliation: Firat University, Faculty of Science Department of Chemistry Elazig Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Koparir
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D061986:MCF-7 Cells; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008352:Mannich Bases / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000378:metabolism; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D014815:Vitamins / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D008352:Mannich Bases; D014230:Triazoles; D014815:Vitamins; C045575:1,2,4-triazole; D008315:Malondialdehyde