title: Resting-state fMRI evidence for early episodic memory consolidation: effects of age.
abstract: Aging-related episodic memory decline is often attributed to insufficient encoding of new information, although the underlying neural processes remain elusive. We here tested the hypothesis that impaired memory consolidation contributes to aging-related memory decline. To this end, we used resting state functional magnetic resonance imaging in healthy young and older adults and investigated neural network connectivity underlying episodic memory consolidation and the effects of aging thereon. During postencoding rest, connectivity increased in subregions of temporobasal and temporo-occipital networks but decreased in a precuneal network. These connectivity changes predicted subsequent memory performance thereby constituting functional correlates of early memory consolidation. Furthermore, these consolidation-related regional connectivity changes partially overlapped with encoding-related neural activity changes, suggesting a close relationship between encoding- and consolidation-related activity. Older when compared to young participants failed to increase connectivity in the right lingual gyrus as part of an extended default mode network during consolidation, thereby providing a functional correlate for spatial contextual memory deficits. In conclusion, results are consistent with previous reports of persistent activity in regions mediating memory encoding as a core mechanism underlying episodic memory consolidation. Our data extend previous findings suggesting that aging-related memory decline results from a reduction of consolidation processes.
authors.affiliation: Cognitive Neuroscience, Institute of Neuroscience and Medicine - Medicine (INM-3), Research Centre Juelich, Jülich, Germany; Department of Neurology, University Hospital, Cologne University, Cologne, Germany. Electronic address: juraj.kukolja@uk-koeln.de.
authors.forename: Juraj
authors.initials: J
authors.lastname: Kukolja
authors.affiliation: Cognitive Neuroscience, Institute of Neuroscience and Medicine - Medicine (INM-3), Research Centre Juelich, Jülich, Germany; Department of Neurology, University Hospital, Cologne University, Cologne, Germany.
authors.forename: D Yasemin
authors.initials: DY
authors.lastname: Göreci
authors.affiliation: Cognitive Neuroscience, Institute of Neuroscience and Medicine - Medicine (INM-3), Research Centre Juelich, Jülich, Germany; Department of Neurology, University Hospital, Cologne University, Cologne, Germany.
authors.forename: Özgür A
authors.initials: ÖA
authors.lastname: Onur
authors.affiliation: Departments of Neuroradiology, Nuclear Medicine, and Technische Universität München-Neuroimaging Center (TUM-NIC), Klinikum Rechts der Isar der Technischen Universität München, Munich, Germany.
authors.forename: Valentin
authors.initials: V
authors.lastname: Riedl
authors.affiliation: Cognitive Neuroscience, Institute of Neuroscience and Medicine - Medicine (INM-3), Research Centre Juelich, Jülich, Germany; Department of Neurology, University Hospital, Cologne University, Cologne, Germany.
authors.forename: Gereon R
authors.initials: GR
authors.lastname: Fink
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology* / Q000523:psychology*; D001921:Brain / Q000000981:diagnostic imaging* / Q000502:physiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D000069077:Memory Consolidation / Q000502:physiology*; D008569:Memory Disorders / Q000000981:diagnostic imaging* / Q000209:etiology / Q000523:psychology*; D061212:Memory, Episodic; D008875:Middle Aged; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000502:physiology / Q000503:physiopathology; D012146:Rest / Q000502:physiology* / Q000523:psychology*; D055815:Young Adult
keywords: Aging; Independent component analysis; Retroactive interference; Source memory