title: Continuing efforts to standardize measured serum growth hormone values in Japan.
abstract: Determination of serum growth hormone (GH) levels is mandatory for diagnosis of GH deficiency and excess. In the present study, we, the Study Committee for GH and Its Related Factors, The Foundation for Growth Science, Japan measured GH values in serum samples using all the commercially available kits in Japan. Significant discrepancies in the GH values were observed among the kits in spite of using the unified recombinant human GH-based standards. To deal with the discrepancies, we established a formula using a linear structural relationship model and were able to standardize the GH values. We propose to use the formula to diagnose GH deficiency and excess in Japan.
authors.affiliation: The Study Committee for GH and Its Related Factors, The Foundation for Growth Science, Tokyo, Japan.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Katsumata
authors.forename: Akira
authors.initials: A
authors.lastname: Shimatsu
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Tachibana
authors.forename: Naomi
authors.initials: N
authors.lastname: Hizuka
authors.forename: Reiko
authors.initials: R
authors.lastname: Horikawa
authors.forename: Susumu
authors.initials: S
authors.lastname: Yokoya
authors.forename: Ke-Ita
authors.initials: KI
authors.lastname: Tatsumi
authors.forename: Takahiro
authors.initials: T
authors.lastname: Mochizuki
authors.forename: Makoto
authors.initials: M
authors.lastname: Anzo
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Tanaka
mesh_terms: D000328:Adult; D003940:Diagnostic Techniques, Endocrine / Q000592:standards*; D006130:Growth Disorders / Q000097:blood / Q000175:diagnosis; D019382:Human Growth Hormone / Q000032:analysis* / Q000097:blood*; D006801:Humans; D007564:Japan; D011933:Reagent Kits, Diagnostic / Q000592:standards; D012015:Reference Standards; D012016:Reference Values
chemical_list: D011933:Reagent Kits, Diagnostic; D019382:Human Growth Hormone