title: Total recognition discriminability in Huntington's and Alzheimer's disease.
abstract: Both the original and second editions of the California Verbal Learning Test (CVLT) provide an index of total recognition discriminability (TRD) but respectively utilize nonparametric and parametric formulas to compute the index. However, the degree to which population differences in TRD may vary across applications of these nonparametric and parametric formulas has not been explored. We evaluated individuals with Huntington's disease (HD), individuals with Alzheimer's disease (AD), healthy middle-aged adults, and healthy older adults who were administered the CVLT-II. Yes/no recognition memory indices were generated, including raw nonparametric TRD scores (as used in CVLT-I) and raw and standardized parametric TRD scores (as used in CVLT-II), as well as false positive (FP) rates. Overall, the patient groups had significantly lower TRD scores than their comparison groups. The application of nonparametric and parametric formulas resulted in comparable effect sizes for all group comparisons on raw TRD scores. Relative to the HD group, the AD group showed comparable standardized parametric TRD scores (despite lower raw nonparametric and parametric TRD scores), whereas the previous CVLT literature has shown that standardized TRD scores are lower in AD than in HD. Possible explanations for the similarity in standardized parametric TRD scores in the HD and AD groups in the present study are discussed, with an emphasis on the importance of evaluating TRD scores in the context of other indices such as FP rates in an effort to fully capture recognition memory function using the CVLT-II.
authors.affiliation: a San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology , San Diego , CA , USA.
authors.forename: Lisa V
authors.initials: LV
authors.lastname: Graves
authors.affiliation: a San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology , San Diego , CA , USA.
authors.forename: Heather M
authors.initials: HM
authors.lastname: Holden
authors.affiliation: a San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology , San Diego , CA , USA.|b Department of Psychiatry , University of California San Diego, School of Medicine , La Jolla , CA , USA.
authors.forename: Lisa
authors.initials: L
authors.lastname: Delano-Wood
authors.affiliation: a San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology , San Diego , CA , USA.|b Department of Psychiatry , University of California San Diego, School of Medicine , La Jolla , CA , USA.
authors.forename: Mark W
authors.initials: MW
authors.lastname: Bondi
authors.affiliation: c Department of Psychology , University of Houston , Houston , TX , USA.
authors.forename: Steven Paul
authors.initials: SP
authors.lastname: Woods
authors.affiliation: a San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology , San Diego , CA , USA.|d Department of Neurosciences , University of California San Diego , La Jolla , CA , USA.
authors.forename: Jody
authors.initials: J
authors.lastname: Corey-Bloom
authors.affiliation: a San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology , San Diego , CA , USA.|d Department of Neurosciences , University of California San Diego , La Jolla , CA , USA.
authors.forename: David P
authors.initials: DP
authors.lastname: Salmon
authors.affiliation: a San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology , San Diego , CA , USA.|b Department of Psychiatry , University of California San Diego, School of Medicine , La Jolla , CA , USA.
authors.forename: Dean C
authors.initials: DC
authors.lastname: Delis
authors.affiliation: a San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology , San Diego , CA , USA.|e Department of Psychology , San Diego State University , San Diego , CA , USA.
authors.forename: Paul E
authors.initials: PE
authors.lastname: Gilbert
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000523:psychology*; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000523:psychology*; D008297:Male; D000073219:Memory and Learning Tests; D008875:Middle Aged; D009483:Neuropsychological Tests; D021641:Recognition, Psychology / Q000502:physiology*
keywords: Alzheimer’s disease; California Verbal Learning Test; California Verbal Learning Test–Second Edition; Huntington’s disease; Recognition discriminability.