title: Imbalance between angiotensin II and angiotensin-(1-7) in human coronary atherosclerosis.
abstract: OBJECTIVE
  Our previous studies found that angiotensin-(1-7) (Ang-(1-7)) is an endogenous counter-factor of angiotensin II (Ang-II). However, the balance between Ang-II and Ang-(1-7) in the development of human coronary atherosclerosis is not determined.
  
  
  RESULTS
  The plasma levels of Ang-II and Ang-(1-7) were detected by enzyme-linked immunosorbent assay (ELISA) in 112 patients with known or suspected coronary artery disease (CAD) undergoing coronary angiography. Patients were divided into three groups based on the coronary angiography as follows: (1) normal (n = 13); (2) noncritical CAD (<50% stenosis, n = 17); and (3) critical CAD (⩾50% stenosis, n = 82). The plasma levels of Ang-II, Ang-(1-7) and the ratio of Ang-II and Ang-(1-7) (Ang-II/Ang-(1-7) were comparable between the normal and noncritical CAD groups. However, Ang-II, Ang-(1-7), and especially Ang-II/Ang-(1-7), were elevated in patients with critical CAD, compared with patients with normal or noncritical CAD. The level of Ang-II/Ang-(1-7) was positively associated with serious coronary stenosis, and correlated with tumor necrosis factor-alpha (TNF-α) level.
  
  
  CONCLUSIONS
  Both Ang-II and Ang-(1-7) expression are significantly increased in patients with critical CAD. However, increased Ang-II/Ang-(1-7) ratios may lead to Ang-II over-activation and aggravate atherosclerosis progression.
authors.affiliation: The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, P.R. China Fine Arts School of Shandong University, P.R. China.
authors.forename: Wenjing
authors.initials: W
authors.lastname: Li
authors.affiliation: The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, P.R. China.
authors.forename: Jifu
authors.initials: J
authors.lastname: Li
authors.affiliation: The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, P.R. China.
authors.forename: Panpan
authors.initials: P
authors.lastname: Hao
authors.affiliation: The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, P.R. China.
authors.forename: Wenqiang
authors.initials: W
authors.lastname: Chen
authors.affiliation: The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, P.R. China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Meng
authors.affiliation: The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, P.R. China.
authors.forename: Hongxuan
authors.initials: H
authors.lastname: Li
authors.affiliation: The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, P.R. China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, P.R. China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Zhang
authors.affiliation: The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, P.R. China yangjianmin@sdu.edu.cn.
authors.forename: Jianmin
authors.initials: J
authors.lastname: Yang
mesh_terms: D000803:Angiotensin I / Q000097:blood*; D000804:Angiotensin II / Q000097:blood*; D050197:Atherosclerosis / Q000097:blood*; D003324:Coronary Artery Disease / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D010446:Peptide Fragments; D014409:Tumor Necrosis Factor-alpha; D000804:Angiotensin II; D000803:Angiotensin I; C118790:angiotensin I (1-7)
keywords: Atherosclerosis; angiotensin II; angiotensin-(1–7); coronary artery disease