title: Catalytic Asymmetric Nucleophilic Addition of 3-Vinyl Indoles to Imines.
abstract: The 3-vinyl indole is used as a nucleophile to react with aromatic and aliphatic imines. Chiral 3-substituted indoles bearing multiple functional groups are produced with up to 99% yield, a 98:2 E/Z ratio, and 97% ee. A possible mechanism is proposed to explain the observed stereoselectivities. This strategy provides an efficient way for the preparation of novel chiral 3-substituted indoles.
authors.affiliation: School of Chemistry and Chemical Engineering, Southwest University , Chongqing, 400715, China.
authors.forename: Jia-Hui
authors.initials: JH
authors.lastname: Xue
authors.affiliation: School of Chemistry and Chemical Engineering, Southwest University , Chongqing, 400715, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Shi
authors.affiliation: School of Chemistry and Chemical Engineering, Southwest University , Chongqing, 400715, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Yu
authors.affiliation: School of Chemistry and Chemical Engineering, Southwest University , Chongqing, 400715, China.
authors.forename: Xiao-Yun
authors.initials: XY
authors.lastname: Li
authors.affiliation: School of Chemistry and Chemical Engineering, Southwest University , Chongqing, 400715, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Ren
authors.affiliation: School of Chemistry and Chemical Engineering, Southwest University , Chongqing, 400715, China.
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Fu
authors.affiliation: School of Chemistry and Chemical Engineering, Southwest University , Chongqing, 400715, China.
authors.forename: Qi-Xiang
authors.initials: QX
authors.lastname: Guo