title: Chemical Composition and in vitro Biological Activities of Essential Oils from Conchocarpus fontanesianus (A. St.-Hil.) Kallunki & Pirani (Rutaceae).
abstract: This study aimed at assessing the chemical composition of the essential oils from leaves and fruits of Conchocarpus fontanesianus, an endemic Brazilian species of Rutaceae. The plant material was harvested from two regions of the Atlantic rainforest in the State of São Paulo. The volatile compounds in the essential oils were extracted by hydrodistillation (HD), and analyzed by GC/FID and GC/MS, allowing the quantification and identification of 54 components in total, which comprise about 97% of the total oil composition. From the leaves collected in Caraguatatuba and Juréia-Itatins, the major volatile compounds identified were as follows: spathulenol (22.32% and 16.67%) and α-cadinol (9.7% and 14.76%). However, β-myrcene (34.56%), (+)-epi-bicyclosesquiphellandrene (8.71%), and bicyclogermacrene (5.80%) were dominant in the fruits collected only in Juréia-Itatins. The in vitro biological activities were tested to evaluate the cytotoxic, antifungal, and antioxidant potential of essential oils from leaves and fruits.
authors.affiliation: Research Center for Plant Physiology and Biochemistry, Institute of Botany, Av. Miguel Estefano, 3687, 04301-012, São Paulo, SP, Brazil.
authors.forename: Rodrigo S
authors.initials: RS
authors.lastname: Cabral
authors.affiliation: Research Center for Biodiversity, Botany Laboratory and Herbarium UNIP and Extraction Laboratory, Paulista University, Av. Paulista, 900, 1° andar, 01310-100, São Paulo, SP, Brazil.
authors.forename: Ivana B
authors.initials: IB
authors.lastname: Suffredini
authors.affiliation: Research Center for Plant Physiology and Biochemistry, Institute of Botany, Av. Miguel Estefano, 3687, 04301-012, São Paulo, SP, Brazil. marxyoungmc@gmail.com.
authors.forename: Maria C M
authors.initials: MC
authors.lastname: Young
mesh_terms: D000935:Antifungal Agents / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology*; D001938:Brazil; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002963:Cladosporium / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005638:Fruit / Q000737:chemistry; D006801:Humans; D061986:MCF-7 Cells; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009822:Oils, Volatile / Q000032:analysis / Q000737:chemistry* / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D027821:Rutaceae / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D000972:Antineoplastic Agents, Phytogenic; D009822:Oils, Volatile
keywords: Atlantic Rainforest; Biological activity; Conchocarpus fontanesianus; Essential oils; Rutaceae