title: Metalloproteolytic receptor shedding…platelets "acting their age".
abstract: Whilst significant effort has been focused on development of tools and approaches to clinically modulate activation processes that consume platelets, the platelet receptors that initiate activation processes remain untargeted. The modulation of receptor levels is also linked to underlying platelet aging processes which influence normal platelet lifespan and also the functionality and survival of stored platelets that are used in transfusion. In this review, we will focus on platelet adhesion receptors initiating thrombus formation, and discuss how regulation of levels of these receptors impact platelet function and platelet survival.
authors.affiliation: a Australian Centre for Blood Diseases , Monash University , Melbourne , Australia.
authors.forename: Robert K
authors.initials: RK
authors.lastname: Andrews
authors.affiliation: b Department of Cancer Biology and Therapeutics, John Curtin School of Medical Research , Australian National University , Canberra , Australia.
authors.forename: Elizabeth E
authors.initials: EE
authors.lastname: Gardiner
mesh_terms: D000818:Animals; D017209:Apoptosis; D001792:Blood Platelets / Q000502:physiology*; D016922:Cellular Senescence; D006801:Humans; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000378:metabolism; D010980:Platelet Membrane Glycoproteins / Q000378:metabolism*; D059748:Proteolysis
chemical_list: D019038:Platelet Glycoprotein GPIb-IX Complex; D010980:Platelet Membrane Glycoproteins; C094990:adhesion receptor; C098341:platelet membrane glycoprotein VI
keywords: Glycoprotein; metalloproteinase; platelet; thrombocytopenia