title: Diabetes converts arterial regulation by perivascular adipose tissue from relaxation into H(2)O(2)-mediated contraction.
abstract: This study aims to reveal the reason for the increased force of 5-hydroxytryptamine-induced contraction of endothelium-denuded skeletal muscle arteries of diabetic rats in the presence of perivascular adipose tissue (PVAT). Our data on rat gracilis arteries show that i) PVAT of skeletal muscle arteries of healthy and diabetic rats releases hydrogen peroxide (H(2)O(2)), ii) higher concentrations of 5-hydroxytryptamine increase the production of H(2)O(2) in PVAT; iii) an enhanced PVAT production of H(2)O(2) is the main, if not the only, reason for the sensitization of arterial contraction to 5-hydroxytriptamine-induced contraction in diabetes and iv) endothelium antagonizes the effect of PVAT-derived H(2)O(2).
authors.affiliation: Cytogenetics Laboratory, University Paediatric Hospital, Medical University, Sofia, Bulgaria; Faculty of Biology, Sofia University St. Kliment Ohridski, Sofia, Bulgaria. hgagov@abv.bg.
authors.forename: R
authors.initials: R
authors.lastname: Emilova
authors.forename: D Z
authors.initials: DZ
authors.lastname: Dimitrova
authors.forename: M
authors.initials: M
authors.lastname: Mladenov
authors.forename: N
authors.initials: N
authors.lastname: Hadzi-Petrushev
authors.forename: T
authors.initials: T
authors.lastname: Daneva
authors.forename: P
authors.initials: P
authors.lastname: Padeshki
authors.forename: R
authors.initials: R
authors.lastname: Schubert
authors.forename: M
authors.initials: M
authors.lastname: Chichova
authors.forename: L
authors.initials: L
authors.lastname: Lubomirov
authors.forename: D
authors.initials: D
authors.lastname: Simeonovska-Nikolova
authors.forename: H
authors.initials: H
authors.lastname: Gagov
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D001158:Arteries / Q000503:physiopathology*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism / Q000503:physiopathology*; D006861:Hydrogen Peroxide / Q000378:metabolism*; D008297:Male; D018482:Muscle, Skeletal / Q000098:blood supply; D017208:Rats, Wistar; D012701:Serotonin; D014661:Vasoconstriction
chemical_list: D012701:Serotonin; D006861:Hydrogen Peroxide