title: [Role of alarmins high mobility group protein B1 in sepsis].
abstract: High mobility group protein B1 (HMGB1) is the most representative substance in the alarmins family, it is actively or passively release to extracellular by the activation of monocyte/macrophage and the dead cells, and then it stimulates the production of a variety of inflammatory mediators, and increases the organism's inflammatory response through relevant receptors signaling pathways. In recent years, its concentration can reflect the severity of inflammation and injury and was related to the prognosis, HMGB1 has won more and more attention in the development of sepsis. By reviewing the study of HMGB1 in sepsis pathogenesis, signal pathway and reversal measures, it was found that HMGB1 was considered as an important inflammatory mediators and warning signal involved in the pathogenesis of sepsis, and was become a new target in the treatment of sepsis. Further research on the role of HMGB1 in the pathogenesis of sepsis is needed in the future, and the development of new drugs combined with HMGB1 will be used in the study of HMGB1 in animal experiments.
authors.affiliation: Zunyi Medical College, Zunyi 563003, Guizhou, China (Wei JX, Liang HP); State Key Laboratory of Trauma, Burn and Combined Injury, Field Surgery Research Institute, Daping Hospital of Third Military Medical University, Chongqing 400042, China (Zhang Y, Ma XY, Tian LX, Liang HP). Corresponding author: Liang Huaping, Email: 13638356728@163.com.
authors.forename: Jiaxin
authors.initials: J
authors.lastname: Wei
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Ma
authors.forename: Lixing
authors.initials: L
authors.lastname: Tian
authors.forename: Huaping
authors.initials: H
authors.lastname: Liang
mesh_terms: D000067531:Alarmins / Q000378:metabolism*; D000818:Animals; D024243:HMGB1 Protein / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D009000:Monocytes / Q000378:metabolism; D018805:Sepsis / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D000067531:Alarmins; D024243:HMGB1 Protein