title: Association between alcohol dehydrogenase-2 gene polymorphism and esophageal cancer risk: a meta-analysis.
abstract: BACKGROUND
  It has been shown that gene polymorphisms may play an important role in the carcinogenesis of esophageal cancer. This study is to investigate the role of alcohol dehydrogenase 1B (ADH1B) gene Arg47His polymorphism in esophageal cancer susceptibility.
  
  
  METHODS
  Case-control studies published between January 2000 and June 2015 were searched to retrieve relevant articles. The pooled odds ratio (OR) and 95 % confidence interval (CI) were employed to calculate the strength of association.
  
  
  RESULTS
  A total of 23 relevant articles were finally selected for the analysis, including 9338 esophageal cancer patients and 14,896 matched controls. Overall, we found that the 47His allele was significant associated with the decreased risk of esophageal cancer when compared with the 47Arg allele in total populations (A vs. G: OR = 0.67, 95 % CI = 0.59-0.76, P < 0.00001). This protective relationship was observed under other genetic models as well (P < 0.00001). Subgroup analysis by ethnicity showed that ADH1B Arg47His variant was associated with the decreased esophageal cancer risk under all the genetic models (P < 0.00001) among Asians, especially in Chinese and Japanese; while in non-Asians, no significant correlation was detected in any genetic models (P > 0.05). Furthermore, Arg/Arg genotype of ADH1B Arg47His variant combined with drinking, smoking and males appeared to show a high risk in patients with esophageal cancer.
  
  
  CONCLUSIONS
  Our results suggested that ADH1B gene Arg47His variant was associated with the decreased esophageal cancer risk. Genetic-environmental interaction should be further considered in the future researches.
authors.affiliation: Department of Cardiothoracic Surgery, Yongchuan Hospital of Chongqing Medical University, No. 439 Xuanhua Road, Yongchuan District, Chongqing, 402160, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Mao
authors.affiliation: Department of Infectious Disease, Yongchuan Hospital of Chongqing Medical University, Chongqing, 402160, China.
authors.forename: Siyao
authors.initials: S
authors.lastname: Nie
authors.affiliation: Department of Cardiothoracic Surgery, Yongchuan Hospital of Chongqing Medical University, No. 439 Xuanhua Road, Yongchuan District, Chongqing, 402160, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Hong
authors.affiliation: Department of Cardiothoracic Surgery, Yongchuan Hospital of Chongqing Medical University, No. 439 Xuanhua Road, Yongchuan District, Chongqing, 402160, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Cardiothoracic Surgery, Yongchuan Hospital of Chongqing Medical University, No. 439 Xuanhua Road, Yongchuan District, Chongqing, 402160, China.
authors.forename: Xueyuan
authors.initials: X
authors.lastname: Shen
authors.affiliation: Department of Cardiothoracic Surgery, Yongchuan Hospital of Chongqing Medical University, No. 439 Xuanhua Road, Yongchuan District, Chongqing, 402160, China. xisontao@yeah.net.
authors.forename: Tao
authors.initials: T
authors.lastname: Xiong
mesh_terms: D000426:Alcohol Dehydrogenase / Q000235:genetics*; D004938:Esophageal Neoplasms / Q000235:genetics* / Q000473:pathology; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors
chemical_list: C489332:ADH1B protein, human; D000426:Alcohol Dehydrogenase
keywords: Alcohol dehydrogenase 1B; Esophageal cancer; Meta-analysis; Polymorphism