title: Entropy-Based Network Representation of the Individual Metabolic Phenotype.
abstract: We approach here the problem of defining and estimating the nature of the metabolite-metabolite association network underlying the human individual metabolic phenotype in healthy subjects. We retrieved significant associations using an entropy-based approach and a multiplex network formalism. We defined a significantly over-represented network formed by biologically interpretable metabolite modules. The entropy of the individual metabolic phenotype is also introduced and discussed.
authors.affiliation: Laboratory of Systems and Synthetic Biology, Wageningen University , Stippeneng 4, 6708 WE Wageningen, The Netherlands.
authors.forename: Edoardo
authors.initials: E
authors.lastname: Saccenti
authors.affiliation: Department of Physics and Astronomy and INFN Sez. Bologna, University of Bologna , Viale Berti Pichat 6/2, 40127 Bologna, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Menichetti
authors.affiliation: Magnetic Resonance Center, University of Florence , via Luigi Sacconi 6, 59100 Sesto Fiorentino, Italy.
authors.forename: Veronica
authors.initials: V
authors.lastname: Ghini
authors.affiliation: Department of Physics and Astronomy and INFN Sez. Bologna, University of Bologna , Viale Berti Pichat 6/2, 40127 Bologna, Italy.
authors.forename: Daniel
authors.initials: D
authors.lastname: Remondini
authors.affiliation: Magnetic Resonance Center, University of Florence , via Luigi Sacconi 6, 59100 Sesto Fiorentino, Italy.|Department of Experimental and Clinical Medicine, University of Florence , Largo Brambilla 3, 50134 Florence, Italy.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Tenori
authors.affiliation: Magnetic Resonance Center, University of Florence , via Luigi Sacconi 6, 59100 Sesto Fiorentino, Italy.|Department of Chemistry, University of Florence , via della Lastruccia 3, 50019 Sesto Fiorentino, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Luchinat
mesh_terms: D019277:Entropy; D064368:Healthy Volunteers; D006801:Humans; D053858:Metabolic Networks and Pathways; D055442:Metabolome; D055432:Metabolomics / Q000379:methods*; D010641:Phenotype
keywords: metabolite modules; metabolite−metabolite association networks; metabolomics; network multiplex