title: Modifications of dietary flavonoids towards improved bioactivity: An update on structure-activity relationship.
abstract: Over the past two decades, extensive studies have revealed that inflammation represents a major risk factor for various human diseases. Chronic inflammatory responses predispose to pathological progression of chronic illnesses featured with penetration of inflammatory cells, dysregulation of cellular signaling, excessive generation of cytokines, and loss of barrier function. Hence, the suppression of inflammation has the potential to delay, prevent, and to treat chronic diseases. Flavonoids, which are widely distributed in humans daily diet, such as vegetables, fruits, tea and cocoa, among others, are considered as bioactive compounds with anti-inflammatory potential. Modification of flavonoids including hydroxylation, o-methylation, and glycosylation, can alter their metabolic features and affect mechanisms of inflammation. Structure-activity relationships among naturally occurred flavonoids hence provide us with a preliminary insight into their anti-inflammatory potential, not only attributing to the antioxidant capacity, but also to modulate inflammatory mediators. The present review summarizes current knowledge and underlies mechanisms of anti-inflammatory activities of dietary flavonoids and their influences involved in the development of various inflammatory-related chronic diseases. In addition, the established structure-activity relationships of phenolic compounds in this review may give an insight for the screening of new anti-inflammatory agents from dietary materials.
authors.affiliation: a College of Food Science , Fujian Agriculture and Forestry University , Fuzhou , Fujian , China.
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
authors.affiliation: a College of Food Science , Fujian Agriculture and Forestry University , Fuzhou , Fujian , China.
authors.forename: Hui
authors.initials: H
authors.lastname: Teng
authors.affiliation: b Jinshan College , Fujian Agriculture and Forestry University , Fuzhou , Fujian , China.
authors.forename: Zhenglu
authors.initials: Z
authors.lastname: Xie
authors.affiliation: c Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Avenida da Universidade , Taipa , Macau.
authors.forename: Hui
authors.initials: H
authors.lastname: Cao
authors.affiliation: c Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Avenida da Universidade , Taipa , Macau.
authors.forename: Wai San
authors.initials: WS
authors.lastname: Cheang
authors.affiliation: d Department of Pharmacognosy with Medicinal Plant Unit , Medical University of Lublin , Lublin , Poland.
authors.forename: Krystyna
authors.identifier: http://orcid.org/0000-0002-9313-5929
authors.initials: K
authors.lastname: Skalicka-Woniak
authors.affiliation: e Group of Plant Cell Biotechnology and Metabolomics , The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences , Plovdiv , Bulgaria.|f Center of Plant Systems Biology and Biotechnology , Plovdiv , Bulgaria.
authors.forename: Milen I
authors.identifier: http://orcid.org/0000-0001-5248-6135
authors.initials: MI
authors.lastname: Georgiev
authors.affiliation: c Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Avenida da Universidade , Taipa , Macau.
authors.forename: Jianbo
authors.initials: J
authors.lastname: Xiao
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology*; D000975:Antioxidants / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology; D001682:Biological Availability; D004032:Diet; D005419:Flavonoids / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology*; D006031:Glycosylation; D006801:Humans; D006900:Hydroxylation; D008745:Methylation; D064209:Phytochemicals / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D005419:Flavonoids; D064209:Phytochemicals
keywords: Anti-inflammation; O-methylation; bioavailability; flavonoids; glycosylation; hydroxylation