title: Hormone therapy and clinical and surrogate cardiovascular endpoints in women with chronic kidney disease: a systematic review and meta-analysis.
abstract: Women with chronic kidney disease (CKD) experience kidney dysfunction-mediated premature menopause. The role of postmenopausal hormone therapy (HT) in this population is unclear. We sought to summarize current knowledge regarding use of postmenopausal HT and cardiovascular (CV) outcomes, and established surrogate measures of CV risk in women with CKD.
  
  
  
  This is a systematic review and meta-analysis of adult women with CKD. We searched electronic bibliographic databases (MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials) (inception to 2014 December), relevant conference proceedings, tables of contents of journals, and review articles. Randomized controlled trials and observational studies examining postmenopausal HT compared with either placebo or untreated control groups were included. The intervention of interest was postmenopausal HT, and the outcome measures were all-cause and CV mortality, nonfatal CV event (myocardial infarction, stroke), and surrogate measures of CV risk (serum lipids, blood pressure).
  
  
  
  Of 12,482 references retrieved, four randomized controlled trials and two cohort studies (N = 1,666 participants) were identified. No studies reported on CV outcomes or mortality. Compared with placebo, postmenopausal HT was associated with decreased low-density lipoprotein cholesterol (-13.2 mg/dL [95% CI, -23.32 to -3.00 mg/dL]), and increased high-density lipoprotein (8.73 mg/dL [95% CI, 4.72-12.73 mg/dL]) and total cholesterol (7.96 mg/dL [95% CI, 0.07-15.84 mg/dL]). No associations were observed between postmenopausal HT triglyceride levels and blood pressure.
  
  
  
  Studies examining the effect of postmenopausal HT on CV outcomes in women with CKD are lacking. Further prospective study of the role of postmenopausal HT in this high-risk group is required.
authors.affiliation: 1Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada 2Libin Cardiovascular Institute of Alberta, Calgary, Alberta, Canada 3Alberta Kidney Disease Network, Alberta, Canada 4Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Boston, MA.
authors.forename: Sharanya
authors.initials: S
authors.lastname: Ramesh
authors.forename: Michelle C
authors.initials: MC
authors.lastname: Mann
authors.forename: Jayna M
authors.initials: JM
authors.lastname: Holroyd-Leduc
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Wilton
authors.forename: Matthew T
authors.initials: MT
authors.lastname: James
authors.forename: Ellen W
authors.initials: EW
authors.lastname: Seely
authors.forename: Sofia B
authors.initials: SB
authors.lastname: Ahmed
mesh_terms: D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000209:etiology*; D002319:Cardiovascular System / Q000187:drug effects*; D015914:Estrogen Replacement Therapy / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008594:Menopause, Premature / Q000097:blood* / Q000187:drug effects; D008875:Middle Aged; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000150:complications
chemical_list: D015415:Biomarkers