title: Association between serum levels of bioavailable vitamin D and negative symptoms in first-episode psychosis.
abstract: Total vitamin D levels had been commonly reported to be lowered in patients with chronic psychotic illnesses in countries from the higher latitudes. However, studies on patients with first episode psychosis (FEP) are limited. In this study we investigated serum concentrations of total and bioavailable vitamin D levels in FEP patients compared to healthy controls and the association between symptom severity and vitamin D components. A total of 31 FEP patients and 31 healthy controls were recruited from Institute of Mental Health, Singapore. FEP patients were identified using Structured Clinical Interview for DSM-IV Axis I disorders (SCID-1) and severity symptoms were assessed using the positive and negative syndrome scale (PANSS). Sera from participants were analyzed for total vitamin D, vitamin D-binding protein (DBP) and bioavailable vitamin D. Linear regressions were performed to examine the associations between serum total and bioavailable vitamin D and the PANSS subscales. Current study noted a significantly lower bioavailable vitamin D was in the FEP group and an association between bioavailable vitamin D and negative symptoms in FEP patients in a population with a consistent supply of sun exposure throughout the year.
authors.affiliation: Research Division, Institute of Mental Health, Singapore. Electronic address: jie_yin_yee@imh.com.sg.
authors.forename: Jie Yin
authors.initials: JY
authors.lastname: Yee
authors.affiliation: Research Division, Institute of Mental Health, Singapore.
authors.forename: Yuen Mei
authors.initials: YM
authors.lastname: See
authors.affiliation: Research Division, Institute of Mental Health, Singapore.
authors.forename: Nur Amirah
authors.initials: NA
authors.lastname: Abdul Rashid
authors.affiliation: Research Division, Institute of Mental Health, Singapore.
authors.forename: Sasi
authors.initials: S
authors.lastname: Neelamekam
authors.affiliation: Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore; Department of General Psychiatry 1, Institute of Mental Health, Singapore.
authors.forename: Jimmy
authors.initials: J
authors.lastname: Lee
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology; D012846:Singapore / Q000453:epidemiology; D014807:Vitamin D / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D014807:Vitamin D
keywords: First-episode psychosis; Schizophrenia; Tropical; Vitamin D