title: Effects of D-allulose on glucose metabolism after the administration of sugar or food in healthy dogs.
abstract: D-allulose is a C-3 epimer of D-fructose and has recently been investigated for its hypoglycemic effects. In the present study, the effects of D-allulose on glucose metabolism were evaluated in healthy dogs administrated sugar or food. The oral administrations of D-allulose decreased plasma glucose concentrations after oral glucose or maltose administration, with a diminished plasma insulin rise. The glucose suppressive effect of D-allulose was also observed after intravenous glucose administrations without increase in plasma insulin concentration. In contrast, D-allulose showed no effect on plasma glucose and insulin concentrations after feeding. The present results suggest that D-allulose administration may be beneficial in dogs with impaired glucose tolerance. Further studies investigating the therapeutic efficacy of D-allulose in diabetic dogs are required.
authors.affiliation: Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
authors.forename: Naohito
authors.initials: N
authors.lastname: Nishii
authors.forename: Toru
authors.initials: T
authors.lastname: Nomizo
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takashima
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Matsubara
authors.forename: Masaaki
authors.initials: M
authors.lastname: Tokuda
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kitagawa
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004285:Dogs / Q000378:metabolism*; D005502:Food; D005632:Fructose / Q000494:pharmacology*; D005947:Glucose / Q000008:administration & dosage / Q000378:metabolism*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D008320:Maltose / Q000008:administration & dosage; D019518:Postprandial Period
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; C003243:psicose; D005632:Fructose; D008320:Maltose; D005947:Glucose