title: Functional Connectivity Networks in Asymptomatic and Symptomatic DYT1 Carriers.
abstract: DYT1 mutation is characterized by focal to generalized dystonia and incomplete penetrance. To explore the complex perturbations in the different neural networks and the mutual interactions among them, we studied symptomatic and asymptomatic DTY1 mutation carriers by resting-state functional MRI.
  
  
  
  A total of 7 symptomatic DYT1, 10 asymptomatic DYT1, and 26 healthy controls were considered. Resting-state functional MRI (Oxford Centre for Functional MRI of the Brain) [FMRIB] Software Library) (FSL) MELODIC, dual regression, (as a toolbox of FSL, with Nets is referred to "networks") (FSLNets) (http://fsl.fmrib.ox.ac.uk/fsl/fslwiki/FSLNets) was performed on 9 resting-state neural networks.
  
  
  
  DYT1 mutation signature (symptomatic DYT1 and asymptomatic DYT1) was characterized by increased connectivity in the dorsal attention network and in the left fronto-parietal network. Functional correlates of symptomatic DYT1 patients (symptomatic DYT1 vs healthy controls) showed increased connectivity in the sensorimotor network.
  
  
  
  This study argues that DYT1 dystonia is a network disorder, with crucial nodes in sensory-motor integration of posterior parietal structures. A better characterization of cortical networks involved in dystonia is crucial for possible neurophysiological therapeutic interventions. © 2016 International Parkinson and Movement Disorder Society.
authors.affiliation: Centre for Ageing Brain and Neurodegenerative Disorders, Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Premi
authors.affiliation: GCS fMRI Koelliker Hospital, Turin, Italy.|Department of Psychology, University of Turin, Turin, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Diano
authors.affiliation: Centre for Ageing Brain and Neurodegenerative Disorders, Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Gazzina
authors.affiliation: GCS fMRI Koelliker Hospital, Turin, Italy.|Department of Psychology, University of Turin, Turin, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Cauda
authors.affiliation: Centre for Ageing Brain and Neurodegenerative Disorders, Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
authors.forename: Vera
authors.initials: V
authors.lastname: Gualeni
authors.affiliation: Department of Neurological and Movement Sciences, University of Verona, Verona, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Tinazzi
authors.affiliation: Department of Neurological and Movement Sciences, University of Verona, Verona, Italy.
authors.forename: Mirta
authors.initials: M
authors.lastname: Fiorio
authors.affiliation: Centre for Ageing Brain and Neurodegenerative Disorders, Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Liberini
authors.affiliation: Neurophysiology Department, University Hospital "Spedali Civili,", Brescia, Italy.
authors.forename: Clara
authors.initials: C
authors.lastname: Lazzarini
authors.affiliation: Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.|Biotechnology Laboratory, Department of Diagnostic, "Spedali Civili" Hospital, Brescia, Italy.
authors.forename: Silvana
authors.initials: S
authors.lastname: Archetti
authors.affiliation: Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.|Biotechnology Laboratory, Department of Diagnostic, "Spedali Civili" Hospital, Brescia, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Biasiotto
authors.affiliation: Neurology Unit, Valle Camonica Hospital, Brescia, Italy.
authors.forename: Marinella
authors.initials: M
authors.lastname: Turla
authors.affiliation: Neurology Unit, Valle Camonica Hospital, Brescia, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Bertasi
authors.affiliation: Neurology Unit, Valle Camonica Hospital, Brescia, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Cotelli
authors.affiliation: Neuroradiology Unit, University of Brescia, Brescia, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Gasparotti
authors.affiliation: Centre for Ageing Brain and Neurodegenerative Disorders, Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Padovani
authors.affiliation: Centre for Ageing Brain and Neurodegenerative Disorders, Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Borroni
mesh_terms: D000328:Adult; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000503:physiopathology*; D063132:Connectome / Q000379:methods*; D004422:Dystonia Musculorum Deformans / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006579:Heterozygote; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D018832:Molecular Chaperones / Q000235:genetics*
chemical_list: D018832:Molecular Chaperones; C108175:TOR1A protein, human
keywords: DYT1; dual regression; dystonia; resting-state functional connectivity