title: Note of the methodological flaws in the paper entitled "GSTT1 and GSTM1 polymorphisms predict treatment outcome for breast cancer: a systematic review and meta-analysis".
abstract: With great interest, we read the paper "GSTT1 and GSTM1 polymorphisms predict treatment outcome for breast cancer: a systematic review and meta-analysis" (by Hu XY et al.), which has reached important conclusions that GSTM1 null and GSTT1/GSTM1 double null polymorphisms might be significantly associated with an increased tumor response in breast cancer. The result is encouraging. Nevertheless, several methodological flaws in this meta-analysis are worth noticing.
authors.affiliation: Department of Geriatrics, Second Xiangya Hospital, Central South University, No.139, Middle Renmin Road, Changsha, 410011, Hunan, China.
authors.forename: Mali
authors.initials: M
authors.lastname: Qiu
authors.affiliation: Department of Geriatrics, Second Xiangya Hospital, Central South University, No.139, Middle Renmin Road, Changsha, 410011, Hunan, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Wu
authors.affiliation: Department of Geriatrics, Second Xiangya Hospital, Central South University, No.139, Middle Renmin Road, Changsha, 410011, Hunan, China. xiaobingqu11@sina.com.
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Qu
mesh_terms: D001943:Breast Neoplasms; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics; D006801:Humans; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D016896:Treatment Outcome
chemical_list: D005982:Glutathione Transferase
keywords: Breast; GSTM1; GSTT1; Meta-analysis; Polymorphisms