title: Trends in One-Year Outcomes of Dialysis-Requiring Acute Kidney Injury in Denmark 2005-2012: A Population-Based Nationwide Study.
abstract: BACKGROUND
  Dialysis-requiring acute kidney injury (AKI) is associated with substantial mortality and risk of end-stage renal disease (ESRD). Despite considerable growth in incidence of severe AKI, information pertaining to trends in outcomes remains limited. We evaluated time trends in one year risks of ESRD and death in patients with dialysis-requiring AKI over an eight year period in Denmark.
  
  
  METHODS
  In a retrospective nationwide study based on national registers, all adults requiring acute renal replacement therapy between 2005 and 2012 were identified. Patients with preceding ESRD were excluded. Through individual-level cross-referencing of administrative registries, information pertaining to comorbidity, preceding surgical interventions, and concurrent other organ failure and sepsis was ascertained. Comparisons of period-specific one year odds ratios for ESRD and death were calculated in a multiple logistic regression model.
  
  
  RESULTS
  A total of 13,819 patients with dialysis-requiring AKI were included in the study. Within one year, 1,017 (7.4%) patients were registered with ESRD, and 7,908 (57.2%) patients died. The one-year rate of ESRD decreased from 9.0% between 2005 and 2006 to 6.1% between 2011 and 2012. Simultaneously, the one-year mortality rate decreased from 58.2% between 2005 and 2006 to 57.5% between 2011 and 2012. Consequently, the adjusted odds ratios for the period 2011-2012 (with the period 2005-2006 as reference) were 0.75 (0.60-0.95, p = 0.015) and 0.87 (95% CI 0.78-0.97, p = 0.010) for ESRD and death, respectively.
  
  
  CONCLUSIONS
  In a nationwide retrospective study on time trends in one year outcomes following dialysis-requiring AKI, risk of all-cause mortality and ESRD decreased over a period of 8 years.
authors.affiliation: Department of Cardiology, Gentofte Hospital, University of Copenhagen, Gentofte, Denmark.|Department of Nephrology, Herlev Hospital, University of Copenhagen, Herlev, Denmark.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Carlson
authors.affiliation: Department of Nephrology, Herlev Hospital, University of Copenhagen, Herlev, Denmark.
authors.forename: Kristine
authors.initials: K
authors.lastname: Hommel
authors.affiliation: Department of Cardiology, Gentofte Hospital, University of Copenhagen, Gentofte, Denmark.
authors.forename: Jonas Bjerring
authors.initials: JB
authors.lastname: Olesen
authors.affiliation: Department of Cardiology, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark.
authors.forename: Anne-Merete
authors.initials: AM
authors.lastname: Soja
authors.affiliation: Center for Diabetes Research, Gentofte Hospital, University of Copenhagen, Gentofte, Denmark.
authors.forename: Tina
authors.initials: T
authors.lastname: Vilsbøll
authors.affiliation: Department of Nephrology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Anne-Lise
authors.initials: AL
authors.lastname: Kamper
authors.affiliation: Institute of Health, Science and Technology, Aalborg University, Aalborg, Denmark.
authors.forename: Christian
authors.initials: C
authors.lastname: Torp-Pedersen
authors.affiliation: Department of Cardiology, Gentofte Hospital, University of Copenhagen, Gentofte, Denmark.
authors.forename: Gunnar
authors.initials: G
authors.lastname: Gislason
mesh_terms: D058186:Acute Kidney Injury / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy; D000368:Aged; D003718:Denmark; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012042:Registries / Q000706:statistics & numerical data*; D006435:Renal Dialysis / Q000706:statistics & numerical data*; D016896:Treatment Outcome