title: Assessment of Blood Loss in Abdominal Myomectomy by Intramyometrial Vasopressin Administration Versus Conventional Tourniquet Application.
abstract: BACKGROUND
  Myomectomy is an invasive surgical procedure. It can be associated with intraoperative and postoperative complications like excessive haemorrhage. There are various methods to control haemorrhage like pharmacological and as well as mechanical methods.
  
  
  OBJECTIVE
  This study was taken to compare intraoperative blood loss following abdominal myomectomy after receiving intramyometrial vasopressin or tourniquet application and to estimate postoperative reduction in haemoglobin & haematocrit values.
  
  
  METHODS
  The study was a randomised single blinded parallel group study. Total 48 patients were included in this study according to inclusion and exclusion criteria. All patients were divided into two groups i.e. 'T' and 'V' group, 24 in each group. 'T' group received conventional tourniquet application and 'V' group received intramyometrial vasopressin administration. The analyses in this study were both sided and p<0.05 was considered significant statistically. The Software used were Statistica version 6 (Tulsa, Oklahoma: Stat Soft Inc., 2001) and Graph Pad Prism version 5 (San Diego, California: Graph Pad Software Inc., 2007).
  
  
  RESULTS
  The blood loss in the tourniquet group was significantly higher (p=<0.001). Postoperative haemoglobin and haematocrit were lower in tourniquet group than vasopressin group. There was significant fall in haemoglobin and haematocrit in postoperative period in both group (p=<0.001) but it was more in tourniquet group. Total five patients (three in tourniquet group and two in vasopressin group) had received one unit whole blood transfusion.
  
  
  CONCLUSIONS
  Intramyometrial vasopressin injection during myomectomy operation more effectively decreases the blood loss, need for blood transfusion and it causes less reduction in haemoglobin and haematocrit. Thereby it seems to be an effective method without having any risk of ischemic damage to the uterus.
authors.affiliation: Senior Resident, Department of Obstetrics and Gynaecology, IPGME&R , Kolkata, West Bengal, India .
authors.forename: Mriganka Mouli
authors.initials: MM
authors.lastname: Saha
authors.affiliation: Senior Resident, Department of Obstetrics and Gynaecology, AIIMS , Patna, Bihar, India .
authors.lastname: Khushboo
authors.affiliation: Professor, Department of Obstetrics and Gynaecology, IPGME&R , Kolkata, West Bengal, India .
authors.forename: Subhash Chandra
authors.initials: SC
authors.lastname: Biswas
authors.affiliation: R.M.O., Department of Obstetrics and Gynaecology, IPGME&R , Kolkata, West Bengal, India .
authors.forename: Hajekul
authors.initials: H
authors.lastname: Alam
authors.affiliation: Professor, Department of Obstetrics and Gynaecology, IPGME&R , Kolkata, West Bengal, India .
authors.forename: Gouri Sankar
authors.initials: GS
authors.lastname: Kamilya
authors.affiliation: Professor, Department of Pathology, IPGME&R , Kolkata, West Bengal, India .
authors.forename: Madhumita
authors.initials: M
authors.lastname: Mukhopadhyay
authors.affiliation: Assistant Professor, Department of Obstetrics and Gynaecology, IPGME&R , Kolkata, West Bengal, India .
authors.forename: Sarbeswar
authors.initials: S
authors.lastname: Mondal
keywords: Benign tumor; Surgical haemorrhage; Uterine myomectomy