title: Mitoxantrone, Etoposide and Prednisolone-a Novel Combination in The Treatment of Relapsed and Refractory Lymphoma.
abstract: A new combination chemotherapy comprising mitoxantrone 10 mg/m(2) iv on day 1, etoposide 100 mg/m(2) iv/po days 1 to 3 and prednisolone 25 mg/m(2) days 1 to 10 was assessed in the treatment of 18 patients with relapsed or refractory Hodgkin's disease or non-Hodgkin's lymphoma. An overall response rate of 74% was achieved. Complete remission occurred in 41% and partial remission in a further 33% of patients. Toxic effects were limited and the regime suitable for out-patient administration. Treatment delays were few and due principally to mild haematological toxicity.
authors.affiliation: a Department of Haematology, East Birmingham Hospital, Birmingham, B9 5ST.
authors.forename: H F
authors.initials: HF
authors.lastname: Barker
authors.affiliation: a Department of Haematology, East Birmingham Hospital, Birmingham, B9 5ST.
authors.forename: R M
authors.initials: RM
authors.lastname: Jan-Mohamed
authors.affiliation: a Department of Haematology, East Birmingham Hospital, Birmingham, B9 5ST.
authors.forename: M J
authors.initials: MJ
authors.lastname: Leyland
authors.affiliation: a Department of Haematology, East Birmingham Hospital, Birmingham, B9 5ST.
authors.forename: D W
authors.initials: DW
authors.lastname: Milligan
keywords: Mitoxantrone lymphoma; etoposide; lymphoma; prednisolone; refractory; relapsed