title: Chronic methamphetamine self-administration disrupts cortical control of cognition.
abstract: Methamphetamine (meth) is one of the most abused substances worldwide. Chronic use has been associated with repeated relapse episodes that may be exacerbated by cognitive impairments during drug abstinence. Growing evidence demonstrates that meth compromises prefrontal cortex activity, resulting in persisting attentional and memory impairments. After summarizing recent studies of meth-induced cognitive dysfunction using a translationally relevant model of self-administered meth, this review emphasizes the cortical brain changes contributing to cognitive dysregulation during abstinence. Finally, we propose the use of cognitive enhancers during abstinence that may promote a drug-free state by reversing cortical dysfunction linked with prolonged meth abuse.
authors.affiliation: Department of Neurosciences, Medical University of South Carolina, Charleston, SC, USA.
authors.forename: Aurelien
authors.initials: A
authors.lastname: Bernheim
authors.affiliation: Department of Psychology, Westmont College, Santa Barbara, CA, USA.
authors.forename: Ronald E
authors.initials: RE
authors.lastname: See
authors.affiliation: Department of Neurosciences, Medical University of South Carolina, Charleston, SC, USA. Electronic address: reichel@musc.edu.
authors.forename: Carmela M
authors.initials: CM
authors.lastname: Reichel
mesh_terms: D019969:Amphetamine-Related Disorders; D003071:Cognition; D006801:Humans; D008569:Memory Disorders; D008694:Methamphetamine / Q000008:administration & dosage*; D012646:Self Administration
chemical_list: D008694:Methamphetamine
keywords: Addiction; Attention; Cognitive deficits; Glutamate; Methamphetamine; Object recognition; Perirhinal; Prefrontal