title: IS THERE A ROLE OF ACTH IN INCREASED CHOROIDAL THICKNESS IN CUSHING SYNDROME?
abstract: OBJECTIVE
  To evaluate choroidal thickness (CT) in patients with Cushing syndrome (CS) with enhanced depth imaging optical coherence tomography.
  
  
  METHODS
  Twenty-eight patients with CS and 38 healthy volunteers were enrolled in this observational cross-sectional study. Patients with newly diagnosed CS who have been admitted to Erciyes University Department of Endocrinology in 3 years time interval were compared with age- and sex-matched healthy volunteers. Choroidal thickness was measured at the fovea and 2 points nasal and 2 points temporal to the fovea with 500-μm intervals each.
  
  
  RESULTS
  Choroidal thickness measurements were higher in patients with CS than in the control group at all examination points; however, the difference was found to be significant at the center of the fovea (367.8 ± 94.4 μm vs. 329 ± 90.5 μm) and 1,000 μm temporal to the fovea. Choroidal thickness measurements were significantly higher in adrenocorticotrophic hormone (ACTH)-dependent CS group than in the control group at all measurement points (CT at fovea 388.2 ± 92.4 μm vs. 329.1 ± 90.5 μm). All CT measurements were found to be correlated with ACTH levels.
  
  
  CONCLUSIONS
  Cushing syndrome is associated with increased CT. The ACTH-dependent CS may increase CT more than ACTH-independent CS. This effect may be directly related to ACTH itself or increased plasma cortisol levels or both.
authors.affiliation: Departments of *Ophthalmology, and †Endocrinology and Metabolism, Erciyes University School of Medicine, Kayseri, Turkey; ‡Department of Ophthalmology, Pazarcik State Hospital, Kahramanmaraş, Turkey; and §Department of Ophthalmology, Kayseri State Research and Education Hospital, Kayseri, Turkey.
authors.forename: Cagatay
authors.initials: C
authors.lastname: Karaca
authors.forename: Zuleyha
authors.initials: Z
authors.lastname: Karaca
authors.forename: Nisa
authors.initials: N
authors.lastname: Kahraman
authors.forename: Ender
authors.initials: E
authors.lastname: Sirakaya
authors.forename: Ayse
authors.initials: A
authors.lastname: Oner
authors.forename: Galip Ertugrul
authors.initials: GE
authors.lastname: Mirza
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D002829:Choroid / Q000000981:diagnostic imaging / Q000473:pathology*; D015862:Choroid Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D003430:Cross-Sectional Studies; D003480:Cushing Syndrome / Q000097:blood / Q000150:complications*; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D015592:Immunoradiometric Assay; D008297:Male; D009929:Organ Size; D011863:Radioimmunoassay; D041623:Tomography, Optical Coherence / Q000379:methods
chemical_list: D019314:Dehydroepiandrosterone Sulfate; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone