title: Genetic associations of the thyroid stimulating hormone receptor gene with Graves diseases and Graves ophthalmopathy: A meta-analysis.
abstract: Graves' disease (GD) is a common thyroid disease, and Graves ophthalmopathy(GO) is the most common extra-thyroidal manifestation of GD. Genetic associations of the thyroid stimulating hormone receptor (TSHR) gene with GD and GO have been studied in different population groups for a long time. We aimed to obtain a more precise estimation of the effects of TSHR single nucleotide polymorphisms (SNPs) on GD/GO using a meta-analysis. Publications were searched on Pub Med and EMBASE up to December 30, 2015. Eight studies involving three SNPs (rs179247, rs12101255, and rs2268458), which included 4790 cases and 5350 controls, met the selection criteria. The pooled odds ratios (OR) and the 95% confidence intervals (CI) were estimated. SNPs rs179247 (dominant model [GG + GA vs. AA]: OR = 0.66, 95%CI: 0.61-0.73, P = 0.000, I(2) = 0%) and rs12101255 (dominant model [TT + TC vs. CC]: OR = 1.67, 95%CI: 1.53-1.83, P = 0.000, I(2) = 0%) were significantly associated with GD in all of the genetic models. TSHR rs12101255 and rs2268458 polymorphisms had no association between GO and GD (GD without GO). The results indicate that rs179247 and rs12101255 are likely to be genetic biomarkers for GD. Further studies with different population groups and larger sample sizes are needed to confirm the genetic associations of the TSHR gene with GD/GO.
authors.affiliation: Department of Ophthalmology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.|Department of Ophthalmology, Chongqing General Hospital, Chongqing, China.
authors.forename: Haibo
authors.initials: H
authors.lastname: Xiong
authors.affiliation: Department of Ophthalmology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Mingxing
authors.initials: M
authors.lastname: Wu
authors.affiliation: Department of Ophthalmology, Chongqing General Hospital, Chongqing, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Yi
authors.affiliation: Department of Ophthalmology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Xiuqing
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Ophthalmology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Centre for Nuclear Receptors and Cell Signalling, Department of Biology and Biochemistry, University of Houston, Houston, TX, USA.
authors.forename: Sophia
authors.initials: S
authors.lastname: Nadirshina
authors.affiliation: Department of Ophthalmology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Xiyuan
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Department of Ophthalmology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Xueqin
authors.initials: X
authors.lastname: Liu
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D049970:Graves Ophthalmopathy / Q000235:genetics*; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011989:Receptors, Thyrotropin / Q000235:genetics*
chemical_list: D011989:Receptors, Thyrotropin