title: Antifungal adjuvants: Preserving and extending the antifungal arsenal.
abstract: As the rates of systemic fungal infections continue to rise and antifungal drug resistance becomes more prevalent, there is an urgent need for new therapeutic options. This issue is exacerbated by the limited number of systemic antifungal drug classes. However, the discovery, development, and approval of novel antifungals is an extensive process that often takes decades. For this reason, there is growing interest and research into the possibility of combining existing therapies with various adjuvants that either enhance activity or overcome existing mechanisms of resistance. Reports of antifungal adjuvants range from plant extracts to repurposed compounds, to synthetic peptides. This approach would potentially prolong the utility of currently approved antifungals and mitigate the ongoing development of resistance.
authors.affiliation: a Department of Clinical Pharmacy , University of Tennessee Health Science Center , Memphis , TN , USA.
authors.forename: Arielle
authors.initials: A
authors.lastname: Butts
authors.affiliation: a Department of Clinical Pharmacy , University of Tennessee Health Science Center , Memphis , TN , USA.
authors.forename: Glen E
authors.initials: GE
authors.lastname: Palmer
authors.affiliation: a Department of Clinical Pharmacy , University of Tennessee Health Science Center , Memphis , TN , USA.
authors.forename: P David
authors.initials: PD
authors.lastname: Rogers
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use*; D002175:Candida / Q000187:drug effects; D002177:Candidiasis / Q000188:drug therapy; D055808:Drug Discovery / Q000379:methods*; D058492:Drug Repositioning; D025141:Drug Resistance, Fungal; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006801:Humans; D009181:Mycoses / Q000188:drug therapy* / Q000382:microbiology; D010455:Peptides / Q000627:therapeutic use; D010936:Plant Extracts / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D010455:Peptides; D010936:Plant Extracts
keywords: antifungals; chemosensitizer; combination therapy; resistance; synergy