title: Excitation/Inhibition Imbalance in Animal Models of Autism Spectrum Disorders.
abstract: Imbalances between excitation and inhibition in synaptic transmission and neural circuits have been implicated in autism spectrum disorders. Excitation and inhibition imbalances are frequently observed in animal models of autism spectrum disorders, and their correction normalizes key autistic-like phenotypes in these animals. These results suggest that excitation and inhibition imbalances may contribute to the development and maintenance of autism spectrum disorders and represent an important therapeutic target.
authors.affiliation: Center for Synaptic Brain Dysfunctions, Institute for Basic Science, Daejeon, Korea.
authors.forename: Eunee
authors.initials: E
authors.lastname: Lee
authors.affiliation: Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea.
authors.forename: Jiseok
authors.initials: J
authors.lastname: Lee
authors.affiliation: Center for Synaptic Brain Dysfunctions, Institute for Basic Science, Daejeon, Korea; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea. Electronic address: kime@kaist.ac.kr.
authors.forename: Eunjoon
authors.initials: E
authors.lastname: Kim
mesh_terms: D000818:Animals; D000067877:Autism Spectrum Disorder / Q000473:pathology* / Q000503:physiopathology; D004195:Disease Models, Animal; D006801:Humans; D009433:Neural Inhibition / Q000502:physiology*; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*
keywords: Autism spectrum disorders; Circuit; Excitation/inhibition balance; Mouse models; Psychiatric disorders; Synapse