title: Mapping and analyzing the human liver proteome: progress and potential.
abstract: The liver is an important organ in humans. Hepatocellular carcinoma (HCC) is one of the deadliest cancers in the world. Progress in the Human Liver Proteome Project (HLPP) has improved understanding of the liver and the liver cancer proteome.
  
  
  
  Here, we summarize the recent progress in liver proteome modification profiles, proteomic studies in liver cancer, proteomic study in the search for novel liver cancer biomarkers and drug targets, and progress of the Chromosome Centric Human Proteome Project (CHPP) in the past five years in the Institutes of Biomedical Sciences (IBS) of Fudan University. Expert commentary: Recent advances and findings discussed here provide great promise of improving the outcome of patients with liver cancer.
authors.affiliation: a Department of Systems Biology for Medicine, School of Basic Medical Sciences , Fudan University , Shanghai , China.|b Minhang Hospital and Institutes of Biomedical Sciences , Fudan University , Shanghai , China.
authors.forename: Hongxiu
authors.initials: H
authors.lastname: Yu
authors.affiliation: a Department of Systems Biology for Medicine, School of Basic Medical Sciences , Fudan University , Shanghai , China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.affiliation: a Department of Systems Biology for Medicine, School of Basic Medical Sciences , Fudan University , Shanghai , China.
authors.forename: Ling
authors.initials: L
authors.lastname: Lin
authors.affiliation: a Department of Systems Biology for Medicine, School of Basic Medical Sciences , Fudan University , Shanghai , China.
authors.forename: Weiqian
authors.initials: W
authors.lastname: Cao
authors.affiliation: c China Liver Cancer Institute, Zhongshan Hospital , Fudan University , Shanghai , China.
authors.forename: Yinkun
authors.initials: Y
authors.lastname: Liu
authors.affiliation: c China Liver Cancer Institute, Zhongshan Hospital , Fudan University , Shanghai , China.
authors.forename: Lunxiu
authors.initials: L
authors.lastname: Qin
authors.affiliation: b Minhang Hospital and Institutes of Biomedical Sciences , Fudan University , Shanghai , China.
authors.forename: Haojie
authors.initials: H
authors.lastname: Lu
authors.affiliation: d State Key Laboratory of Proteomics, Beijing Proteome Research Center , Beijing Institute of Radiation Medicine , Beijing , China.
authors.forename: Fuchu
authors.initials: F
authors.lastname: He
authors.affiliation: a Department of Systems Biology for Medicine, School of Basic Medical Sciences , Fudan University , Shanghai , China.|b Minhang Hospital and Institutes of Biomedical Sciences , Fudan University , Shanghai , China.
authors.forename: Huali
authors.initials: H
authors.lastname: Shen
authors.affiliation: a Department of Systems Biology for Medicine, School of Basic Medical Sciences , Fudan University , Shanghai , China.|b Minhang Hospital and Institutes of Biomedical Sciences , Fudan University , Shanghai , China.
authors.forename: Pengyuan
authors.initials: P
authors.lastname: Yang
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology; D020543:Proteome / Q000235:genetics*; D040901:Proteomics
chemical_list: D020543:Proteome
keywords: Liver; biomarker; glycosylation; liver cancer; metastasis; proteomics