title: Lanthanum chloride enhances cisplatin-induced apoptosis in ovarian cancer cells.
abstract: Ovarian cancer begins in an ovary. It is the leading cause of mortality from gynecologic cancer. Cisplatin is an anti-ovarian tumor drug. However, repeated use of cisplatin causes serious resistance. Recently, Lanthanum chloride (LaCl3) was found to inhibit the proliferation and promote the apoptosis in some cancer cells. In this study, we investigated the influence of LaCl3 on cisplatin-induced apoptosis in the ovarian cell line (COC1). Cell-based assays and analysis of cellular ultra structure were used. Result showed that LaCl3 enhanced cisplatin-induced apoptosis in COC1. Furthermore, the application of Cisplatin also altered the expression level of tumor related proteins, such as ERCC1, Ki67, and CDK6. Overall, we determined the inhibitory effect of LaCl3 on the COC1 growth when treated with Cisplatin, which may serve as a basis for the clinical application of LaCl3 in the treatment of ovarian cancer.
authors.affiliation: The First Affiliated Hospital of Nanchang University Department of Obstetrics and Gynecology Nanchang China.
authors.forename: F
authors.initials: F
authors.lastname: Wang
authors.affiliation: The First Affiliated Hospital of Nanchang University Department of Obstetrics and Gynecology Nanchang China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: The First Affiliated Hospital of Nanchang University Department of Obstetrics and Gynecology Nanchang China.
authors.forename: S
authors.initials: S
authors.lastname: Fang
authors.affiliation: The First Affiliated Hospital of Nanchang University Department of Obstetrics and Gynecology Nanchang China.
authors.forename: S
authors.initials: S
authors.lastname: Li
authors.affiliation: The First Affiliated Hospital of Nanchang University Department of Obstetrics and Gynecology Nanchang China sisunliu1@sina.com.
authors.forename: S
authors.initials: S
authors.lastname: Liu
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002945:Cisplatin / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007811:Lanthanum / Q000494:pharmacology*; D009363:Neoplasm Proteins / Q000378:metabolism; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000648:ultrastructure
chemical_list: D009363:Neoplasm Proteins; C028521:lanthanum chloride; D007811:Lanthanum; D002945:Cisplatin