title: Role of bile acids in the regulation of the metabolic pathways.
abstract: Recent studies have revealed that bile acids (BAs) are not only facilitators of dietary lipid absorption but also important signaling molecules exerting multiple physiological functions. Some major signaling pathways involving the nuclear BAs receptor farnesoid X receptor and the G protein-coupled BAs receptor TGR5/M-BAR have been identified to be the targets of BAs. BAs regulate their own homeostasis via signaling pathways. BAs also affect diverse metabolic pathways including glucose metabolism, lipid metabolism and energy expenditure. This paper suggests the mechanism of controlling metabolism via BA signaling and demonstrates that BA signaling is an attractive therapeutic target of the metabolic syndrome.
authors.affiliation: Hiroki Taoka, Tatsuya Tanigaki, Department of Environmental Information, Keio University, Fujisawa, Kanagawa 252-0882, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Taoka
authors.affiliation: Hiroki Taoka, Tatsuya Tanigaki, Department of Environmental Information, Keio University, Fujisawa, Kanagawa 252-0882, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Yokoyama
authors.affiliation: Hiroki Taoka, Tatsuya Tanigaki, Department of Environmental Information, Keio University, Fujisawa, Kanagawa 252-0882, Japan.
authors.forename: Kohkichi
authors.initials: K
authors.lastname: Morimoto
authors.affiliation: Hiroki Taoka, Tatsuya Tanigaki, Department of Environmental Information, Keio University, Fujisawa, Kanagawa 252-0882, Japan.
authors.forename: Naho
authors.initials: N
authors.lastname: Kitamura
authors.affiliation: Hiroki Taoka, Tatsuya Tanigaki, Department of Environmental Information, Keio University, Fujisawa, Kanagawa 252-0882, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Tanigaki
authors.affiliation: Hiroki Taoka, Tatsuya Tanigaki, Department of Environmental Information, Keio University, Fujisawa, Kanagawa 252-0882, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Takashina
authors.affiliation: Hiroki Taoka, Tatsuya Tanigaki, Department of Environmental Information, Keio University, Fujisawa, Kanagawa 252-0882, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tsubota
authors.affiliation: Hiroki Taoka, Tatsuya Tanigaki, Department of Environmental Information, Keio University, Fujisawa, Kanagawa 252-0882, Japan.
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Watanabe
keywords: Bariatric surgery; Bile acid binding resin; Bile acids; Energy metabolism; Farnesoid X receptor; Glucose metabolism; Incretin; Lipid metabolism; Microbiota; TGR5/M-BAR