title: Mechanism of Biological Compatibility of Water-Soluble Yb3+, Er3+ Codoped NaYF4 Nanoparticles.
abstract: Water soluble NaYF4 nanocrystals codoped with 20 mol% Yb3+, 2 mol% Er3+ were prepared by a facile solvothermal approach using polyvinylpyrrolidone (PVP) as a surfactant. As a potential material for luminescent probes, in votroeffects of upconversion nanoparticles (UCNPs) on human aenocarcinoma (SGC-7901) cells with different concentrations were observed. These effects range from cell viability, mitochondrial membrane potential (MMP), reactive oxygen species (ROS) production, AnnexinV-FITC-propidium iodide (PI) apoptosis detection, and cell cycles. Our results demonstrated that the cells treated with UCNPs showed a decrease in cell viability accompanied the decreased MMP and the release of ROS. When treated with 400 µg/mL UCNPs, AnnexinV-FITC-PI apoptosis detection showed the UCNPs induced apoptosis, the cell cycle indicated the UCNPs suppressor cells in the G1 phase obviously, thereby reducing cell activity.
authors.forename: Chen
authors.initials: C
authors.lastname: Liu
authors.forename: Huan
authors.initials: H
authors.lastname: Chen
authors.forename: Shouying
authors.initials: S
authors.lastname: Li
authors.forename: Hong
authors.initials: H
authors.lastname: Xu
authors.forename: Dan
authors.initials: D
authors.lastname: Zhao
mesh_terms: D001672:Biocompatible Materials; D002470:Cell Survival / Q000187:drug effects*; D004871:Erbium / Q000737:chemistry / Q000633:toxicity; D005459:Fluorides / Q000737:chemistry* / Q000633:toxicity*; D008422:Materials Testing; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000633:toxicity* / Q000648:ultrastructure; D012995:Solubility; D014867:Water / Q000737:chemistry; D015018:Ytterbium / Q000737:chemistry / Q000633:toxicity; D015019:Yttrium / Q000737:chemistry* / Q000633:toxicity*
chemical_list: D001672:Biocompatible Materials; C525362:sodium yttriumtetrafluoride; D014867:Water; D015019:Yttrium; D004871:Erbium; D015018:Ytterbium; D005459:Fluorides