title: Innate immune cell responses in non pathogenic versus pathogenic SIV infections.
abstract: HIV-1/SIVmac infections deeply disturb innate host responses. Most studies have focused on the impact on dendritic cells and NK cells. A few but insufficient data are available on other innate immune cell types, such as neutrophils. It has been shown that innate lymphoid cells are depleted early and irreversibly during SIVmac/HIV-1 infections. Studies in natural hosts of SIV have contributed to pinpoint that early control of inflammation is crucial. In natural hosts, plasmacytoid dendritic cells, myeloid dendritic cells and NK cells are depleted during acute infection but return to normal levels by the end of acute infection. We summarize here the similarities and differences of various types of innate immune responses in natural hosts compared to pathogenic HIV/SIV mac infections.
authors.affiliation: Institut Pasteur, Unité HIV, Inflammation and Persistence, Paris, France; CEA, Division of Immuno-Virology, iMETI, DSV, Fontenay-aux-Roses, France; Vaccine Research Institute, Créteil, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Huot
authors.affiliation: Institut Pasteur, Unité HIV, Inflammation and Persistence, Paris, France; Vaccine Research Institute, Créteil, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Rascle
authors.affiliation: Institut Pasteur, Unité HIV, Inflammation and Persistence, Paris, France.
authors.forename: Thalia
authors.initials: T
authors.lastname: Garcia-Tellez
authors.affiliation: Institut Pasteur, Unité HIV, Inflammation and Persistence, Paris, France.
authors.forename: Beatrice
authors.initials: B
authors.lastname: Jacquelin
authors.affiliation: Institut Pasteur, Unité HIV, Inflammation and Persistence, Paris, France; Vaccine Research Institute, Créteil, France. Electronic address: michaela.muller-trutwin@pasteur.fr.
authors.forename: Michaela
authors.initials: M
authors.lastname: Müller-Trutwin
mesh_terms: D000818:Animals; D003713:Dendritic Cells / Q000276:immunology / Q000473:pathology; D054884:Host-Pathogen Interactions; D007113:Immunity, Innate; D007249:Inflammation / Q000517:prevention & control / Q000821:virology; D007694:Killer Cells, Natural / Q000276:immunology / Q000473:pathology; D008253:Macaca mulatta; D009504:Neutrophils / Q000276:immunology; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000276:immunology* / Q000472:pathogenicity* / Q000502:physiology