title: Elevated synovial fluid concentration of adenosine triphosphate in dogs with osteoarthritis or sodium urate-induced synovitis of the stifle.
abstract: Adenosine triphosphate has been shown to stimulate nociceptive nerve terminals in joints. Elevated synovial fluid adenosine triphosphate concentrations as well as a correlation between synovial fluid adenosine triphosphate concentrations and osteoarthritic knee pain has been demonstrated in humans, but not yet in dogs. This study documented elevated synovial fluid adenosine triphosphate concentrations in the stifles of dogs with secondary osteoarthritis and urate-induced synovitis, as compared to normal stifles.
authors.affiliation: Dr. Bryan T. Torres, University of Missouri, Department of Veterinary Medicine and Surgery, 900 East Campus Drive, Columbia, Missouri 65211, United States, E-mail: torresb@missouri.edu.
authors.forename: Bryan T
authors.initials: BT
authors.lastname: Torres
authors.forename: David A
authors.initials: DA
authors.lastname: Jimenez
authors.forename: Steven C
authors.initials: SC
authors.lastname: Budsberg
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D004283:Dog Diseases / Q000378:metabolism*; D004285:Dogs; D005260:Female; D008297:Male; D010003:Osteoarthritis / Q000378:metabolism / Q000662:veterinary*; D013264:Stifle / Q000378:metabolism*; D013582:Synovial Fluid / Q000378:metabolism*; D013585:Synovitis / Q000139:chemically induced / Q000378:metabolism / Q000662:veterinary*; D014527:Uric Acid
chemical_list: D014527:Uric Acid; D000255:Adenosine Triphosphate
keywords: Osteoarthritis; adenosine triphosphate; synovial fluid; urate