title: A Histomorphologic Grading System That Predicts Overall Survival in Diffuse Malignant Peritoneal Mesothelioma With Epithelioid Subtype.
abstract: Diffuse malignant peritoneal mesothelioma (MPeM) is rare and arises from peritoneal serosal surfaces. Although it shares similar histomorphology with its counterpart, malignant pleural mesothelioma, etiologies, clinical courses, and therapies differ. Nuclear grading and level of mitoses have been correlated with prognosis in malignant pleural mesothelioma with epithelioid subtype. Whether nuclear grading and level of mitoses correlate with prognosis in MPeM is still unknown. Our study utilizes a 2 tier system incorporating nuclear features and level of the mitoses to stratify cases of MPeM with epithelioid subtype. Fifty-one cases of MPeM with clinical follow-up underwent retrospective microscopic review. From that subset, 46 cases were of epithelioid subtype, which were then stratified into a low-grade or high-grade tier. Survival times were calculated on the basis of Kaplan-Meier analysis. The low-grade tier had higher overall survival with a median of 11.9 years and 57% at 5 years when compared with the high-grade tier with a median of 3.3 years and 21% at 5 years (P=0.002). Although not statistically significant, the low-grade tier had higher progression-free survival with a median of 4.7 years and 65% at 5 years when compared with the high-grade tier with a median of 1.9 years and 35% at 5 years (P=0.089). Our study is first to specifically evaluate and correlate nuclear features and level of mitoses with overall survival in MPeM with epithelioid subtype.
authors.affiliation: Departments of *Pathology †Surgery ‡Biostatistical Sciences, Wake Forest Baptist Health, Winston-Salem, NC §Department of Pathology, The University of Mississippi Medical Center, Jackson, MS ∥Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.
authors.forename: Kari
authors.initials: K
authors.lastname: Valente
authors.forename: Aaron U
authors.initials: AU
authors.lastname: Blackham
authors.forename: Edward
authors.initials: E
authors.lastname: Levine
authors.forename: Greg
authors.initials: G
authors.lastname: Russell
authors.forename: Konstantinos I
authors.initials: KI
authors.lastname: Votanopoulos
authors.forename: John H
authors.initials: JH
authors.lastname: Stewart
authors.forename: Perry
authors.initials: P
authors.lastname: Shen
authors.forename: Kim R
authors.initials: KR
authors.lastname: Geisinger
authors.forename: Sahussapont J
authors.initials: SJ
authors.lastname: Sirintrapun
mesh_terms: D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008654:Mesothelioma / Q000401:mortality* / Q000473:pathology*; D060787:Neoplasm Grading / Q000379:methods*; D010534:Peritoneal Neoplasms / Q000401:mortality* / Q000473:pathology*