title: A Metalloregulated Four-State Nanoswitch Controls Two-Step Sequential Catalysis in an Eleven-Component System.
abstract: The nanomechanical switch 1 with its three orthogonal binding motifs-the zinc(II) porphyrin, azaterpyridine, and shielded phenanthroline binding station-is quantitatively and reversibly toggled back and forth between four different switching states by means of addition and removal of appropriate metal-ion inputs. Two of the four switching stages are able to initiate catalytic transformations (ON1, ON2), while the two others shut down any reaction (OFF1, OFF2). Thus, in a cyclic four-state switching process the sequential transformation A+B+C→AB+C→ABC can be controlled, which proceeds stepwise along the switching states OFF1→ON1 (click reaction: A+B→AB)→OFF2→ON2 (Michael addition: AB+C→ABC)→OFF1. Two consecutive cycles of the sequential catalysis were realized without loss in activity in a reaction system with eleven different components.
authors.affiliation: Center of Micro and Nanochemistry and Engineering, Organische Chemie I, Universität Siegen, Adolf-Reichwein Str. 2, 57068, Siegen, Germany.
authors.forename: Sudhakar
authors.initials: S
authors.lastname: Gaikwad
authors.affiliation: Center of Micro and Nanochemistry and Engineering, Organische Chemie I, Universität Siegen, Adolf-Reichwein Str. 2, 57068, Siegen, Germany.
authors.forename: Abir
authors.initials: A
authors.lastname: Goswami
authors.affiliation: Center of Micro and Nanochemistry and Engineering, Organische Chemie I, Universität Siegen, Adolf-Reichwein Str. 2, 57068, Siegen, Germany.
authors.forename: Soumen
authors.initials: S
authors.lastname: De
authors.affiliation: Center of Micro and Nanochemistry and Engineering, Organische Chemie I, Universität Siegen, Adolf-Reichwein Str. 2, 57068, Siegen, Germany. Schmittel@chemie.uni-siegen.de.
authors.forename: Michael
authors.identifier: 0000-0001-8622-2883
authors.initials: M
authors.lastname: Schmittel
keywords: allosteric control; coordination chemistry; molecular switches; nanomechanical motion; sequential catalysis