title: Synthesis and Characterization of α-ZrP@CHI Drug Deliver System.
abstract: This paper described the controlled synthesis and release properties of a new kind of multifunctional drug-release system which was prepared by encapsulation of zirconium bis-(monohydrogen orthophosphate) monohydrate (α-ZrP) with chitosan (CHI). As obtained the α-ZrP@CHI nanocomposites were found to possess the structural features of both α-ZrP and CHI. The release properties of the α-ZrP@CHI nanocomposites were evaluated using Gentamicin sulfate as the model drug. And α-ZrP@CHI composites showed a prolonged drug release time compared with α-ZrP, which can be attributed to the unique lamellar structure and the encapsulation with CHI. The controlled synthesis of α-ZrP@CHI nanocomposite thus provided a new opportunity for future development of delivery vehicles.
authors.forename: Shiyong
authors.initials: S
authors.lastname: Yu
authors.forename: Xuechuan
authors.initials: X
authors.lastname: Gao
authors.forename: Renfei
authors.initials: R
authors.lastname: Zhang
authors.forename: Zhao
authors.initials: Z
authors.lastname: Li
authors.forename: Zhibing
authors.initials: Z
authors.lastname: Tan
authors.forename: Haiquan
authors.initials: H
authors.lastname: Su
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000138:chemical synthesis*; D004058:Diffusion; D005839:Gentamicins / Q000008:administration & dosage / Q000737:chemistry*; D008422:Materials Testing; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure*; D015040:Zirconium / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D005839:Gentamicins; D053769:Nanocapsules; C027006:zirconium phosphate; D048271:Chitosan; D015040:Zirconium