title: New Genetics and Genomic Data on Pancreatic Neuroendocrine Tumors: Implications for Diagnosis, Treatment, and Targeted Therapies.
abstract: The recent findings on the roles of death-associated protein 6/α-thalassemia/mental retardation X-linked (DAXX/ATRX) in the development of pancreatic neuroendocrine tumors (PanNETs) have led to major advances in the molecular understanding of these rare tumors and open up completely new therapeutic windows. This overview aims at giving a simplified view on these findings and their possible therapeutic implications. The importance of epigenetic changes in PanNET is also underlined by recent findings of a cross-species study on microRNA (miRNA) and messenger RNA (mRNA) profiles in PanNETs.
authors.affiliation: Institute of Pathology, University of Bern, Murtenstrasse 31, 3010, Bern, Switzerland. anja.schmitt@pathology.unibe.ch.
authors.forename: Anja M
authors.initials: AM
authors.lastname: Schmitt
authors.affiliation: Institute of Pathology, University of Bern, Murtenstrasse 31, 3010, Bern, Switzerland.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Marinoni
authors.affiliation: Institute of Pathology, University of Bern, Murtenstrasse 31, 3010, Bern, Switzerland.
authors.forename: Annika
authors.initials: A
authors.lastname: Blank
authors.affiliation: Institute of Pathology, University of Bern, Murtenstrasse 31, 3010, Bern, Switzerland.
authors.forename: Aurel
authors.initials: A
authors.lastname: Perren
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics; D000818:Animals; D056970:Co-Repressor Proteins; D023281:Genomics; D006801:Humans; D018832:Molecular Chaperones; D058990:Molecular Targeted Therapy / Q000379:methods / Q000639:trends; D018358:Neuroendocrine Tumors / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D009687:Nuclear Proteins / Q000235:genetics; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D056970:Co-Repressor Proteins; C106985:DAXX protein, human; D018832:Molecular Chaperones; D009687:Nuclear Proteins
keywords: Alternative lengthening of telomeres; DAXX/ATRX; Epigenetics; Methylation; Pancreatic neuroendocrine tumor; Review