title: [Relationship between structural and functional changes in retina in Stargardt disease].
abstract: OBJECTIVE
  To assess the relationship between structural abnormalities of the junction of the internal and external segments of photoreceptors (IS/OS junction) and functional changes.
  
  
  METHODS
  The study enrolled 45 patients (90 eyes) with Stargardt disease, of them 22 women and 23 men. Ophthalmic examination included color vision test, static perimetry with a 60° field of view, electrophysiological studies, namely, ganzfeld and multifocal electroretinography (gERG and mfERG), autofluorescence, and optical coherence tomography (OCT).
  
  
  RESULTS
  For analysis, the patients were divided into 3 groups depending on whether or not the structure of the IS/OS junction was damaged at OCT. A strong correlation has been found between the level of IS/OS damage and the MD index. There were no differences in foveal, perifoveal, or parafoveal retinal thicknesses. Retinal volumes within the 1-, 3- and 6-mm ring-shaped zones were also similar. All three groups showed a reduction in amplitudes of the major gERG waves and mfERG changes of different severity. The most frequent defect seen in all groups and the ring-shaped zones was a reduction in the amplitude and density of retinal biopotential (P1μv and P1 nv/deg2).
  
  
  CONCLUSIONS
  A direct correlation exists between the extent and severity of structural changes in the IS/OS junction at OCT, visual functions assessed with perimetry, and disturbance of electrogenesis detected by mfERG and gERG.
authors.affiliation: Research Institute of Eye Diseases, 11 A, B, Rossolimo St., Moscow, Russian Federation, 119021.
authors.forename: N L
authors.initials: NL
authors.lastname: Sheremet
authors.affiliation: Research Institute of Eye Diseases, 11 A, B, Rossolimo St., Moscow, Russian Federation, 119021.
authors.forename: I A
authors.initials: IA
authors.lastname: Ronzina
authors.affiliation: Research Institute of Eye Diseases, 11 A, B, Rossolimo St., Moscow, Russian Federation, 119021.
authors.forename: N V
authors.initials: NV
authors.lastname: Zhorzholadze
authors.affiliation: Research Centre of Medical Genetics, 1 Moskvorech'e St., Moscow, Russian Federation, 115478.
authors.forename: V V
authors.initials: VV
authors.lastname: Strel'nikov
mesh_terms: D000328:Adult; D055253:Color Vision; D003937:Diagnosis, Differential; D042241:Early Diagnosis; D004596:Electroretinography / Q000379:methods; D005260:Female; D006801:Humans; D008268:Macular Degeneration / Q000151:congenital* / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D008297:Male; D018579:Patient Selection; D020419:Photoreceptor Cells, Vertebrate / Q000473:pathology*; D055213:Retinal Pigment Epithelium / Q000473:pathology / Q000503:physiopathology; D012720:Severity of Illness Index; D000080362:Stargardt Disease; D013223:Statistics as Topic; D041623:Tomography, Optical Coherence / Q000379:methods; D058609:Visual Field Tests / Q000379:methods