title: Prevalence of Small Intestinal Bacterial Overgrowth among Chronic Pancreatitis Patients: A Case-Control Study.
abstract: Background. Patients with chronic pancreatitis (CP) exhibit numerous risk factors for the development of small intestinal bacterial overgrowth (SIBO). Objective. To determine the prevalence of SIBO in patients with CP. Methods. Prospective, single-centre case-control study conducted between January and September 2013. Inclusion criteria were age 18 to 75 years and clinical and radiological diagnosis of CP. Exclusion criteria included history of gastric, pancreatic, or intestinal surgery or significant clinical gastroparesis. SIBO was detected using a standard lactulose breath test (LBT). A healthy control group also underwent LBT. Results. Thirty-one patients and 40 controls were included. The patient group was significantly older (53.8 versus 38.7 years; P < 0.01). The proportion of positive LBTs was significantly higher in CP patients (38.7 versus 2.5%: P < 0.01). A trend toward a higher proportion of positive LBTs in women compared with men was observed (66.6 versus 27.3%; P = 0.056). The subgroups with positive and negative LBTs were comparable in demographic and clinical characteristics, use of opiates, pancreatic enzymes replacement therapy (PERT), and severity of symptoms. Conclusion. The prevalence of SIBO detected using LBT was high among patients with CP. There was no association between clinical features and the risk for SIBO.
authors.affiliation: Laboratoire de Neurogastroentérologie et Motricité Digestive, Service de Gastroentérologie, Hôpital Saint-Luc, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC, Canada H2X 3J4.
authors.forename: Amelie
authors.identifier: 0000-0002-6911-8598
authors.initials: A
authors.lastname: Therrien
authors.affiliation: Laboratoire de Neurogastroentérologie et Motricité Digestive, Service de Gastroentérologie, Hôpital Saint-Luc, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC, Canada H2X 3J4.
authors.forename: Simon
authors.initials: S
authors.lastname: Bouchard
authors.affiliation: Laboratoire de Neurogastroentérologie et Motricité Digestive, Service de Gastroentérologie, Hôpital Saint-Luc, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC, Canada H2X 3J4.
authors.forename: Sacha
authors.initials: S
authors.lastname: Sidani
authors.affiliation: Laboratoire de Neurogastroentérologie et Motricité Digestive, Service de Gastroentérologie, Hôpital Saint-Luc, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC, Canada H2X 3J4.
authors.forename: Mickael
authors.identifier: 0000-0003-4272-6793
authors.initials: M
authors.lastname: Bouin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001765:Blind Loop Syndrome / Q000453:epidemiology* / Q000209:etiology; D001944:Breath Tests / Q000379:methods; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007421:Intestine, Small / Q000382:microbiology; D007792:Lactulose / Q000032:analysis; D008297:Male; D008875:Middle Aged; D050500:Pancreatitis, Chronic / Q000382:microbiology*; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D055815:Young Adult
chemical_list: D007792:Lactulose