title: A New Combination of Idarubicin, Etoposide and Cytarabine in Untreated Acute Non-Lymphoblastic Leukemia.
abstract: Sixty-seven unselected adult patients with untreated acute non lymphotblastic leukemia (ANLL) ranging in age from 15 to 80 years received a new induction regimen consisting of Idarubicin, Etoposide and Cytarabine. Patients who entered complete remission (CR) were then allocated to 4 courses of post remission intensification. After this, patients under 50 years of age with a compatible donor were given allogeneic bone marrow transplantation (BMT) or autologous BMT (ABMT) in those without an HLA-compatible donor; the remainder, older than 50, did not receive further therapy. Fifty-six of 67 patients (83.5%) achieved CR (02.5% in young and 70.3% in old patients) and 40 (71 %) after the first course. Seven patients (of whom, 6 were > 50 years) died in aplasia during the induction phase and four additional patients (all elderly) died during post-remission intensification without recurrent disease. Subsequently, the younger patients received transplants (BMT: 4 pts; ABMT: 10 pts). Twelve: of the 52 (23%) who survived post remission intensification (BMT: 1; ABMT: 4; others: 7) are disease free survivors 9-67 months (median, 32 months) after achieving CR. In conclusion, this intensive chemotherapy regimen is highly effective both in young and odder patients but the post-remission intensification may be too aggressive for elderly patients.
authors.affiliation: a Bone Marrow Transplantation Unit and Division of Haematology, Ospedale S. Martino, Genova, Italy.
authors.forename: A M
authors.initials: AM
authors.lastname: Carella
authors.affiliation: a Bone Marrow Transplantation Unit and Division of Haematology, Ospedale S. Martino, Genova, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Gaozza
authors.affiliation: a Bone Marrow Transplantation Unit and Division of Haematology, Ospedale S. Martino, Genova, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Piatti
authors.affiliation: a Bone Marrow Transplantation Unit and Division of Haematology, Ospedale S. Martino, Genova, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Nati
authors.affiliation: a Bone Marrow Transplantation Unit and Division of Haematology, Ospedale S. Martino, Genova, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Pungoltno
authors.affiliation: a Bone Marrow Transplantation Unit and Division of Haematology, Ospedale S. Martino, Genova, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Santini
authors.affiliation: a Bone Marrow Transplantation Unit and Division of Haematology, Ospedale S. Martino, Genova, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Giordano
authors.affiliation: a Bone Marrow Transplantation Unit and Division of Haematology, Ospedale S. Martino, Genova, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Cerri
authors.affiliation: a Bone Marrow Transplantation Unit and Division of Haematology, Ospedale S. Martino, Genova, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Risso
authors.affiliation: a Bone Marrow Transplantation Unit and Division of Haematology, Ospedale S. Martino, Genova, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Rossi
authors.affiliation: a Bone Marrow Transplantation Unit and Division of Haematology, Ospedale S. Martino, Genova, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Spriano
authors.affiliation: a Bone Marrow Transplantation Unit and Division of Haematology, Ospedale S. Martino, Genova, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Coingiu
authors.affiliation: a Bone Marrow Transplantation Unit and Division of Haematology, Ospedale S. Martino, Genova, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Carlier
authors.affiliation: a Bone Marrow Transplantation Unit and Division of Haematology, Ospedale S. Martino, Genova, Italy.
authors.forename: M R
authors.initials: MR
authors.lastname: Raffo
authors.affiliation: a Bone Marrow Transplantation Unit and Division of Haematology, Ospedale S. Martino, Genova, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Damagio
authors.affiliation: a Bone Marrow Transplantation Unit and Division of Haematology, Ospedale S. Martino, Genova, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Bacigalupo
authors.affiliation: a Bone Marrow Transplantation Unit and Division of Haematology, Ospedale S. Martino, Genova, Italy.
authors.forename: A M
authors.initials: AM
authors.lastname: Marmont
keywords: ANLL; Arac; VP 16; ldarubicin; leukemia