title: Access to Fluoropyrrolidines by Intramolecular Aza-Michael Addition Reaction.
abstract: Study of the intramolecular aza-Michael addition reaction from an aminofluorovinylsulfone opens a new route for the synthesis of pyrrolidine derivatives. An unexpected diastereoselective cyclization reaction was observed, leading preferentially to the anti-N-benzylpyrrolidine sulfone. The resulting sulfone was reacted with aldehydes to access β-substituted α-fluoroalkenyl pyrrolidines in one step.
authors.affiliation: Normandie University, LCMT, ENSICAEN, UNICAEN, CNRS , 14000 Caen, France.
authors.forename: Clothilde
authors.initials: C
authors.lastname: Le Guen
authors.affiliation: Normandie University, LCMT, ENSICAEN, UNICAEN, CNRS , 14000 Caen, France.
authors.forename: Minh-Loan
authors.initials: ML
authors.lastname: Tran Do
authors.affiliation: Normandie University, LCMT, ENSICAEN, UNICAEN, CNRS , 14000 Caen, France.
authors.forename: Aurélien
authors.initials: A
authors.lastname: Chardon
authors.affiliation: Normandie University, LCMT, ENSICAEN, UNICAEN, CNRS , 14000 Caen, France.
authors.forename: Cyril
authors.initials: C
authors.lastname: Lebargy
authors.affiliation: Normandie University, LCMT, ENSICAEN, UNICAEN, CNRS , 14000 Caen, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Lohier
authors.affiliation: Normandie University, LCMT, ENSICAEN, UNICAEN, CNRS , 14000 Caen, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Pfund
authors.affiliation: Normandie University, LCMT, ENSICAEN, UNICAEN, CNRS , 14000 Caen, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Lequeux