title: IGFBP-1 marker of cervical ripening and predictor of preterm birth.
abstract: Aim To establish a correlation between positive values of IGFBP-1(>10 mg/L, Actim Partus Test, APT) and premature cervical ripening in imminent preterm labor. Methods A prospective study was conducted in primary health care centers in Tuzla, Gynecology and Obstetrics Clinic of the University Clinical Centre in Tuzla and General Hospital Tešanj. The study included 50 women (singleton pregnancy, 28-37 week) with imminent preterm labor diagnosed by cervical biometry and modified Bishop score) (examinees) and 30 healthy pregnant women (control group). The presence of IGFBP-1 was tested in cervical secretion several times in weeks 28-37 until a positive test was shown. Results IGFBP-1 was positive in 43 (86%) examinees and in six (20%) patients from the control group (p=0.001). In 31 (62%) examinees APT was positive in weeks 28-30, and in nine (18%) in weeks 31- 33, while three (6%) examinees had positive test in 34-37 week; in the control group, three (10%) were tested positive in weeks 31-33 and three (10%) in weeks 34-37. At first testing (28-30 weeks) APT was statistically significantly more frequently positive in the examined group (p<0.05). Later, tests did not find statistically significant difference in the frequency of positivity between the control and examined group (p=0.08). Conclusion Elevated values of IGFBP -1 in cervical secretion were highly correlated with preterm labor. Screening for IGFBP could help in preventing preterm labor and its complications.
authors.affiliation: Department of Gynecology and Obstetrics, General Hospital Tešanj; Bosnia and Herzegovina.
authors.forename: Larisa
authors.initials: L
authors.lastname: Mešić Ðogić
authors.affiliation: Hospital of Obstetrics and Gynecology, Clinical Hospital Centre "Dragiša Mišović" Belgrade; Serbia.
authors.forename: Dragana
authors.initials: D
authors.lastname: Mićić
authors.affiliation: School of Medicine Tuzla, University Tuzla; Obstetrics and Gynecology Practice "Omeragić" Tuzla; Bosnia and Herzegovina.
authors.forename: Feđa
authors.initials: F
authors.lastname: Omeragić
authors.affiliation: Department of Pediatics, General Hospital Tešanj; Bosnia and Herzegovina.
authors.forename: Refka
authors.initials: R
authors.lastname: Kovač
authors.affiliation: Department of Surgery, General Hospital Tešanj; Bosnia and Herzegovina.
authors.forename: Seid
authors.initials: S
authors.lastname: Fazlagić
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D020070:Cervical Ripening / Q000378:metabolism*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000378:metabolism*; D007752:Obstetric Labor, Premature / Q000175:diagnosis*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D015415:Biomarkers; C032231:IGFBP1 protein, human; D018970:Insulin-Like Growth Factor Binding Protein 1
keywords: cervix mucus; insulin-like growth factor binding proteins; premature birth