title: LncRNAs in pancreatic cancer.
abstract: Pancreatic cancer (PC) is one of the most common causes of cancer-related death. The underlying mechanism of PC is not completely understood at present. Studies in recent years have demonstrated that long non-coding RNAs (lncRNAs) have multiple biological functions in cell growth, differentiation and proliferation. Notably, expressions of some lncRNAs undergo significant changes in the initiation and progression of cancers. In addition, lncRNAs are reported to be involved in various steps of PC development and have a potential value in the diagnosis, treatment and prognostic prediction of PC. In this review, we highlight recent evidence related to the molecular mechanism of lncRNAs in growth, survival, invasion, metastasis, angiogenesis and apoptosis of PC cells, and discuss the potential clinical application of lncRNAs to the diagnosis, treatment and prognostic prediction of PC.
authors.affiliation: Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Cell Biology, Second Military Medical University, Shanghai, China.
authors.forename: Xiaosong
authors.initials: X
authors.lastname: Zhi
authors.affiliation: Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Yisha
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Na
authors.initials: N
authors.lastname: Ta
authors.affiliation: Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Jianming
authors.initials: J
authors.lastname: Zheng
mesh_terms: D000818:Animals; D017209:Apoptosis; D014408:Biomarkers, Tumor / Q000378:metabolism; D002454:Cell Differentiation; D049109:Cell Proliferation; D018450:Disease Progression; D006801:Humans; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009389:Neovascularization, Pathologic; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D062085:RNA, Long Noncoding
keywords: clinical; lncRNA; mechanism; pancreatic cancer; pathogen