title: Central Nervous System Complications of Hematopoietic Stem Cell Transplant.
abstract: Hematopoietic stem cell transplantation (SCT) is now commonly used to treat several hematologic and nonhematologic diseases. Central nervous system (CNS) complications post-transplantation occur commonly in the first year and result in increased mortality from infectious, toxic, metabolic, or vascular causes. Infections secondary to aspergillus, toxoplasma and viruses cause many of the complications. Drug-related toxicities arising from conditioning regimens and graft-versus-host disease prophylaxis, as well as intraparenchymal hemorrhage, are not uncommon and can result in increased morbidity. Secondary CNS cancers have a higher incidence 5 or more years after allogeneic SCT.
authors.affiliation: Division of Neuroradiology, Department of Radiology, VA Ann Arbor Health System, University of Michigan Health System, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA.
authors.forename: Faiz I
authors.initials: FI
authors.lastname: Syed
authors.affiliation: BMT Program, Huntsman Cancer Center, University of Utah, 2000 Circle of Hope. Office #2151, Salt Lake City, UT 84112, USA.
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Couriel
authors.affiliation: Department of Pharmacy, University of Michigan Health System, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA.
authors.forename: David
authors.initials: D
authors.lastname: Frame
authors.affiliation: Division of Neuroradiology, Department of Radiology, University of Michigan Health System, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address: ashoks@med.umich.edu.
authors.forename: Ashok
authors.initials: A
authors.lastname: Srinivasan
mesh_terms: D064591:Allografts; D002494:Central Nervous System Infections / Q000209:etiology / Q000628:therapy; D002543:Cerebral Hemorrhage / Q000209:etiology / Q000628:therapy; D006086:Graft vs Host Disease / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans
keywords: CNS complications; CNS drug toxicity; CNS infection; PRES; Stem cell transplant