title: Novel association of soluble intercellular adhesion molecule 1 and soluble P-selectin with the ABO blood group in a Chinese population.
abstract: Recent studies have reported that theABOgene can affect circulating expression levels of soluble intercellular adhesion molecule 1 (sICAM-1) and soluble P-selectin (sP-selectin) in Caucasians. However, several factors may affect the association, including the distribution and variations of theABOgene, ethnic diversity and the inflammatory response status. The aim of the present study was to investigate this issue in Asian subjects of various blood groups. A total of 800 blood samples were randomly selected from healthy blood donors. The ABO blood groups were examined using standard serological tests, and ABO genotypes of group A and group AB specimens were analyzed. Plasma concentrations of sICAM-1 and sP-selectin were detected by standard enzyme-linked immunosorbent assays. In healthy Chinese individuals, blood group A was detected to be significantly associated with lower circulating expression levels of sICAM-1 and sP-selectin, compared with group O. Individuals with ≥1 A1 allele had significantly lower expression levels of sICAM-1 and sP-selectin compared with all other ABO groups. The data indicate the significant association of ABO blood group antigens with sICAM-1 and sP-selectin expression levels in a healthy Chinese population, independent of the specific variations and distributions of ABO blood groups among ethnic populations. This result provides evidence for the previously unidentified role of ABO blood group antigens in the regulation of the inflammatory adhesion process. Accordingly, it can be proposed that ABO blood groups may require consideration when soluble adhesion molecules are identified as predictors for cardiovascular disease.
authors.affiliation: Blood Group Reference and Research Laboratory, Blood Center of Shandong, Jinan, Shandong 250012, P.R. China.
authors.forename: Wenjing
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Blood Group Reference and Research Laboratory, Blood Center of Shandong, Jinan, Shandong 250012, P.R. China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Xu
authors.affiliation: Blood Group Reference and Research Laboratory, Blood Center of Shandong, Jinan, Shandong 250012, P.R. China.
authors.forename: Yunlong
authors.initials: Y
authors.lastname: Zhuang
authors.affiliation: Blood Group Reference and Research Laboratory, Blood Center of Shandong, Jinan, Shandong 250012, P.R. China.
authors.forename: Yuanfeng
authors.initials: Y
authors.lastname: Chen
keywords: ABO blood group; cardiovascular disease; inflammatory diseases; soluble P-selectin; soluble intercellular adhesion molecule 1