title: [Protect role of Netrin-1 in inflammatory response].
abstract: Neuronal guidance factor Netrin-1 has been known to be involved in nervous system development by controlling neuronal migration through both chemoattractive and chemo-repulsive signaling by binding different receptors. Netrin-1 has been shown to play a positively regulatory role during inflammatory process recently. Since the chemorepulsive receptors were found in leukocytes, it is suggest that Netrin-1 played a protective role in tissue through inhibiting leukocyte trafficking and accumulating during inflammatory process in researches. It is demonstrated that Netrin-1 can limit inflammatory response through the involvement of inflammatory cascades, attenuate hypoxia-inducible tissue injury and suppress apoptosis concurrently. It is indicated that Netrin-1 can be a novel target in future through preventing and inhibiting inflammatory diseases in these researches. This review will focus on recent relevant advances and in-depth study to elucidate its mechanism of anti-inflammation.
authors.affiliation: Department of Acute Abdominal Surgery, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning, China (Tang ZK, Xu CM, Zhang GX, Chen HL); Department of Traditional Chinese Medicine, the Affiliated Maternity Hospital of Dalian Medical University, Dalian 116033, Liaoning, China (Xu CM). Corresponding author: Chen Hailong, Email: hailongchen2013@163.com.
authors.forename: Zhankai
authors.initials: Z
authors.lastname: Tang
authors.forename: Caiming
authors.initials: C
authors.lastname: Xu
authors.forename: Guixin
authors.initials: G
authors.lastname: Zhang
authors.forename: Hailong
authors.initials: H
authors.lastname: Chen
mesh_terms: D002465:Cell Movement; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D007962:Leukocytes / Q000166:cytology*; D009414:Nerve Growth Factors / Q000378:metabolism*; D000075388:Netrin-1; D025521:Tumor Suppressor Proteins / Q000378:metabolism*
chemical_list: C000617351:NTN1 protein, human; D009414:Nerve Growth Factors; D025521:Tumor Suppressor Proteins; D000075388:Netrin-1