title: Genotype frequencies for polymorphisms related to chemotherapy-induced nausea and vomiting in a Japanese population.
abstract: BACKGROUND
  Genotype frequencies for chemotherapy-induced nausea and vomiting (CINV)-related polymorphisms have not yet been reported for Japanese subjects.
  
  
  METHODS
  We analyzed 10 genotype frequencies for following polymorphisms associated with the development of CINV: serotonin 5-HT3 receptors (HTR3); neurokinin-1 receptors (Tachykinin-1 receptors, TACR1); dopamine D2 receptors (DRD2); and catechol-O-methyltransferase (COMT).
  
  
  RESULTS
  All polymorphisms were successfully genotyped in 200 Japanese subjects and were in Hardy-Weinberg equilibrium. Almost all genotype frequencies were similar to those in the HapMap database or in the previous reports, while frequencies for the Y192H polymorphism in TACR1 were different in Japanese subjects from those in a previous report.
  
  
  CONCLUSIONS
  The present study revealed genotype frequencies for polymorphisms, which were related to the appearance of CINV in Japanese subjects. Individual therapy based on genotype variations for each race is needed to allow cancer patients to undergo chemotherapy more safely and to understand etiology of CINV.
authors.affiliation: Division of Clinical Sciences and Neuropsychopharmacology, Faculty and Graduate School of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku Nagoya, 468-8503 Japan.
authors.forename: Aya
authors.initials: A
authors.lastname: Goto
authors.affiliation: Division of Clinical Sciences and Neuropsychopharmacology, Faculty and Graduate School of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku Nagoya, 468-8503 Japan.
authors.forename: Haruka
authors.initials: H
authors.lastname: Kotani
authors.affiliation: Division of Clinical Sciences and Neuropsychopharmacology, Faculty and Graduate School of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku Nagoya, 468-8503 Japan ; Department of Neuropsychopharmacology and Hospital Pharmacy, Graduate School of Medicine, Nagoya University, 65 Tsurumai-cho, Showa-ku Nagoya, 466-8550 Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Miyazaki
authors.affiliation: Department of Neuropsychopharmacology and Hospital Pharmacy, Graduate School of Medicine, Nagoya University, 65 Tsurumai-cho, Showa-ku Nagoya, 466-8550 Japan.
authors.forename: Kiyofumi
authors.initials: K
authors.lastname: Yamada
authors.affiliation: Department of Neuropsychopharmacology and Hospital Pharmacy, Graduate School of Medicine, Nagoya University, 65 Tsurumai-cho, Showa-ku Nagoya, 466-8550 Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Ishikawa
authors.affiliation: Aichi Health Promotion Foundation, 1-18-4, Shimizu, Kita-ku, Nagoya, 462-0844 Japan.
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Shimoyama
authors.affiliation: Faculty of Health and Nutrition, Shubun University, 6 Nikko-cho, Ichinomiya, Aichi 491-0938 Japan.
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Niwa
authors.affiliation: Department of Respiratory Medicine, Graduate School of Medicine, Nagoya University, 65 Tsurumai-cho, Showa-ku Nagoya, 466-8550 Japan.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Hasegawa
authors.affiliation: Division of Clinical Sciences and Neuropsychopharmacology, Faculty and Graduate School of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku Nagoya, 468-8503 Japan ; Department of Neuropsychopharmacology and Hospital Pharmacy, Graduate School of Medicine, Nagoya University, 65 Tsurumai-cho, Showa-ku Nagoya, 466-8550 Japan.
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Noda
keywords: Chemotherapy-induced nausea and vomiting; Gene polymorphism; Japanese population