title: Fatty acid metabolism in fish species as a biomarker for environmental monitoring.
abstract: Pollution by Organic Contaminants (OC) in aquatic environments is a relevant issue at the global scale. Lipids comprised of Fatty Acids (FA) play many important roles in the physiology and life history of fishes. Toxic effects of OC are partly dependent on its bioaccumulation in the lipids of aquatic organisms due its physicochemical properties. Therefore, there is an increasing interest to investigate the gene expression as well as the presence and activity of proteins involved in FA metabolism. The attention on Peroxisome Proliferation Activate Receptors (PPARs) also prevails in fish species exposed to OC and in the transport, biosynthesis and β-oxidation of FA. Several studies have been conducted under controlled conditions to evaluate these biological aspects of fish species exposed to OC, as fibrates, endocrine disrupting compounds, perfluoroalkyl acids, flame retardants, metals and mixtures of organic compounds associated with a polluted area. However, only fibrates, which are agonists of PPARs, induce biological responses suitable to be considered as biomarkers of exposure to these pollutants. According to the documented findings on this topic, it is unlikely that these physiological aspects are suitable to be employed as biomarkers with some noticeable exceptions, which depend on experimental design. This emphasises the need to investigate the responses in fish treated with mixtures of OC and in wild fish species from polluted areas to validate or refute the suitability of these biomarkers for environmental or fish health monitoring.
authors.affiliation: Laboratorio de Toxicología Ambiental, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Av. Wilfrido Massieu s/n, Unidad Profesional Zacatenco, Ciudad de México, C. P. 07738, Mexico. Electronic address: hugolivares@yahoo.com.mx.
authors.forename: Hugo F
authors.initials: HF
authors.lastname: Olivares-Rubio
authors.affiliation: Laboratorio de Toxicología Ambiental, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Av. Wilfrido Massieu s/n, Unidad Profesional Zacatenco, Ciudad de México, C. P. 07738, Mexico. Electronic address: avegadv@yahoo.com.mx.
authors.forename: Armando
authors.initials: A
authors.lastname: Vega-López
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D052244:Endocrine Disruptors / Q000633:toxicity; D004784:Environmental Monitoring / Q000379:methods*; D005227:Fatty Acids / Q000378:metabolism*; D029941:Fish Proteins / Q000378:metabolism; D005399:Fishes / Q000378:metabolism*; D050356:Lipid Metabolism / Q000187:drug effects*; D009930:Organic Chemicals; D047492:Peroxisome Proliferator-Activated Receptors / Q000378:metabolism; D014874:Water Pollutants, Chemical / Q000633:toxicity*; D015262:Xenobiotics / Q000633:toxicity
chemical_list: D015415:Biomarkers; D052244:Endocrine Disruptors; D005227:Fatty Acids; D029941:Fish Proteins; D009930:Organic Chemicals; D047492:Peroxisome Proliferator-Activated Receptors; D014874:Water Pollutants, Chemical; D015262:Xenobiotics
keywords: Biomarkers; Fatty acid metabolism; Fish; PPARs