title: Unraveling the Complexities of Life Sciences Data.
abstract: The life sciences have entered into the realm of big data and data-enabled science, where data can either empower or overwhelm. These data bring the challenges of the 5 Vs of big data: volume, veracity, velocity, variety, and value. Both independently and through our involvement with DELSA Global (Data-Enabled Life Sciences Alliance, DELSAglobal.org), the Kolker Lab ( kolkerlab.org ) is creating partnerships that identify data challenges and solve community needs. We specialize in solutions to complex biological data challenges, as exemplified by the community resource of MOPED (Model Organism Protein Expression Database, MOPED.proteinspire.org ) and the analysis pipeline of SPIRE (Systematic Protein Investigative Research Environment, PROTEINSPIRE.org ). Our collaborative work extends into the computationally intensive tasks of analysis and visualization of millions of protein sequences through innovative implementations of sequence alignment algorithms and creation of the Protein Sequence Universe tool (PSU). Pushing into the future together with our collaborators, our lab is pursuing integration of multi-omics data and exploration of biological pathways, as well as assigning function to proteins and porting solutions to the cloud. Big data have come to the life sciences; discovering the knowledge in the data will bring breakthroughs and benefits.
authors.affiliation: 1 Bioinformatics and High-throughput Analysis Laboratory, Seattle Children's Research Institute , Seattle, Washington.|2 High-throughput Analysis Core, Center for Developmental Therapeutics, Seattle Children's Research Institute , Seattle, Washington.|3 Predictive Analytics, Seattle Children's , Seattle, Washington.|4 Data-Enabled Life Sciences Alliance (DELSA Global) , Seattle, Washington.
authors.forename: Roger
authors.initials: R
authors.lastname: Higdon
authors.affiliation: 1 Bioinformatics and High-throughput Analysis Laboratory, Seattle Children's Research Institute , Seattle, Washington.|2 High-throughput Analysis Core, Center for Developmental Therapeutics, Seattle Children's Research Institute , Seattle, Washington.|3 Predictive Analytics, Seattle Children's , Seattle, Washington.|4 Data-Enabled Life Sciences Alliance (DELSA Global) , Seattle, Washington.
authors.forename: Winston
authors.initials: W
authors.lastname: Haynes
authors.affiliation: 1 Bioinformatics and High-throughput Analysis Laboratory, Seattle Children's Research Institute , Seattle, Washington.|2 High-throughput Analysis Core, Center for Developmental Therapeutics, Seattle Children's Research Institute , Seattle, Washington.|3 Predictive Analytics, Seattle Children's , Seattle, Washington.|4 Data-Enabled Life Sciences Alliance (DELSA Global) , Seattle, Washington.
authors.forename: Larissa
authors.initials: L
authors.lastname: Stanberry
authors.affiliation: 1 Bioinformatics and High-throughput Analysis Laboratory, Seattle Children's Research Institute , Seattle, Washington.|4 Data-Enabled Life Sciences Alliance (DELSA Global) , Seattle, Washington.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Stewart
authors.affiliation: 1 Bioinformatics and High-throughput Analysis Laboratory, Seattle Children's Research Institute , Seattle, Washington.|2 High-throughput Analysis Core, Center for Developmental Therapeutics, Seattle Children's Research Institute , Seattle, Washington.|4 Data-Enabled Life Sciences Alliance (DELSA Global) , Seattle, Washington.
authors.forename: Gregory
authors.initials: G
authors.lastname: Yandl
authors.affiliation: 4 Data-Enabled Life Sciences Alliance (DELSA Global) , Seattle, Washington.|5 Center for Developmental Therapeutics, Seattle Children's Research Institute , Seattle, Washington.
authors.forename: Chris
authors.initials: C
authors.lastname: Howard
authors.affiliation: 2 High-throughput Analysis Core, Center for Developmental Therapeutics, Seattle Children's Research Institute , Seattle, Washington.|3 Predictive Analytics, Seattle Children's , Seattle, Washington.|4 Data-Enabled Life Sciences Alliance (DELSA Global) , Seattle, Washington.
authors.forename: William
authors.initials: W
authors.lastname: Broomall
authors.affiliation: 2 High-throughput Analysis Core, Center for Developmental Therapeutics, Seattle Children's Research Institute , Seattle, Washington.|3 Predictive Analytics, Seattle Children's , Seattle, Washington.|4 Data-Enabled Life Sciences Alliance (DELSA Global) , Seattle, Washington.
authors.forename: Natali
authors.initials: N
authors.lastname: Kolker
authors.affiliation: 1 Bioinformatics and High-throughput Analysis Laboratory, Seattle Children's Research Institute , Seattle, Washington.|2 High-throughput Analysis Core, Center for Developmental Therapeutics, Seattle Children's Research Institute , Seattle, Washington.|3 Predictive Analytics, Seattle Children's , Seattle, Washington.|4 Data-Enabled Life Sciences Alliance (DELSA Global) , Seattle, Washington.|6 Departments of Biomedical Informatics & Medical Education and Pediatrics, University of Washington , Seattle, Washington.
authors.forename: Eugene
authors.initials: E
authors.lastname: Kolker