title: The Role of Optical Coherence Tomography Angiography in the Diagnosis and Management of Acute Vogt-Koyanagi-Harada Disease.
abstract: OBJECTIVE
  To report the imaging characteristics of acute Vogt-Koyanagi-Harada (VKH) disease using optical coherence tomography angiography (OCTA).
  
  
  METHODS
  In this prospective study, patients with acute VKH (n = 10; mean age: 30.5 ± 13.43 years) underwent multimodal imaging (baseline and follow-up) using fundus photography, fluorescein angiography (FA), indocyanine green angiography (ICGA), OCT, and OCTA. The OCTA images were analyzed to assess the retinochoroidal vasculature and compared with other imaging techniques.
  
  
  RESULTS
  During the active stage, all eyes showed multiple foci of choriocapillaris flow void that correlated with ICGA. These foci decreased in number and size after initiation of therapy. In one patient, flow void areas reappeared after cessation of therapy without any detectable change on ICGA. This patient soon developed clinical recurrence requiring re-initiation of immunosuppression.
  
  
  CONCLUSIONS
  OCTA allows high-resolution imaging of inflammatory foci suggestive of choriocapillaris hypoperfusion in acute VKH disease non-invasively. OCTA may be very helpful in the follow-up of such patients.
authors.affiliation: a Advanced Eye Center , Post Graduate Institute of Medical Education and Research , Chandigarh , India.
authors.forename: Kanika
authors.initials: K
authors.lastname: Aggarwal
authors.affiliation: b Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center , Omaha , Nebraska , USA.
authors.forename: Aniruddha
authors.identifier: http://orcid.org/0000-0003-4985-9855
authors.initials: A
authors.lastname: Agarwal
authors.affiliation: a Advanced Eye Center , Post Graduate Institute of Medical Education and Research , Chandigarh , India.
authors.forename: Sarakshi
authors.initials: S
authors.lastname: Mahajan
authors.affiliation: c Eye Clinic, Department of Biomedical and Clinical Science "Luigi Sacco", Luigi Sacco Hospital , University of Milan , Milan , Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Invernizzi
authors.affiliation: a Advanced Eye Center , Post Graduate Institute of Medical Education and Research , Chandigarh , India.
authors.forename: Spoorti Krishna Reddy
authors.initials: SKR
authors.lastname: Mandadi
authors.affiliation: a Advanced Eye Center , Post Graduate Institute of Medical Education and Research , Chandigarh , India.
authors.forename: Ramandeep
authors.initials: R
authors.lastname: Singh
authors.affiliation: a Advanced Eye Center , Post Graduate Institute of Medical Education and Research , Chandigarh , India.
authors.forename: Reema
authors.initials: R
authors.lastname: Bansal
authors.affiliation: a Advanced Eye Center , Post Graduate Institute of Medical Education and Research , Chandigarh , India.
authors.forename: Mangat R
authors.initials: MR
authors.lastname: Dogra
authors.affiliation: a Advanced Eye Center , Post Graduate Institute of Medical Education and Research , Chandigarh , India.
authors.forename: Vishali
authors.initials: V
authors.lastname: Gupta
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002829:Choroid / Q000098:blood supply; D004396:Coloring Agents / Q000008:administration & dosage; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D006801:Humans; D007208:Indocyanine Green / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D010781:Photography; D011446:Prospective Studies; D041623:Tomography, Optical Coherence; D014607:Uveomeningoencephalitic Syndrome / Q000175:diagnosis*; D055815:Young Adult
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green
keywords: Choriocapillaris; EDI-OCT; Vogt–Koyanagi–Harada syndrome; indocyanine green angiography; multimodal imaging; optical coherence tomography angiography