title: Cyclodextrins 3-Functionalized with 8-Hydroxyquinolines: Copper-Binding Ability and Inhibition of Synuclein Aggregation.
abstract: Neurodegenerative diseases such as Parkinson's and Alzheimer's diseases are multifactorial disorders related to protein aggregation, metal dyshomeostasis, and oxidative stress. To advance understanding in this area and to contribute to therapeutic development, many efforts have been directed at devising suitable agents that can target metal ions associated with relevant biomolecules such as α-synuclein. This paper presents a new cyclodextrin-8-hydroxyquinoline conjugate and discusses the properties of four cyclodextrins 3-functionalized with 8-hydroxyquinoline as copper(II) chelators and inhibitors of copper-induced synuclein aggregation. The encouraging results establish the potential of cyclodextrin-8-hydroxyquinoline conjugates as chelators for the control of copper toxicity.
authors.affiliation: Dipartimento di Scienze Chimiche, Università degli Studi di Catania, viale A. Doria 6, 95125, Catania, Italy.|Consorzio Interuniversitario di Ricerca in Chimica dei Metalli nei Sistemi Biologici, C.I.R.C.M.S.B., Unità di Ricerca di Catania, 95125, Catania, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Oliveri
authors.affiliation: Dipartimento di Scienze Chimiche, Università degli Studi di Catania, viale A. Doria 6, 95125, Catania, Italy.
authors.forename: Carmelo
authors.initials: C
authors.lastname: Sgarlata
authors.affiliation: Dipartimento di Scienze Chimiche, Università degli Studi di Catania, viale A. Doria 6, 95125, Catania, Italy. gr.vecchio@unict.it.
authors.forename: Graziella
authors.identifier: http://orcid.org/0000-0001-8305-081X
authors.initials: G
authors.lastname: Vecchio
mesh_terms: D000992:Antitoxins / Q000494:pharmacology; D001665:Binding Sites; D003300:Copper / Q000737:chemistry*; D003505:Cyclodextrins / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006912:Hydroxyquinolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D066263:Protein Aggregation, Pathological / Q000517:prevention & control*; D051844:alpha-Synuclein / Q000037:antagonists & inhibitors* / Q000737:chemistry
chemical_list: C000607489:8-hydroxyquinoline-cyclodextrin; D000992:Antitoxins; D003505:Cyclodextrins; D006912:Hydroxyquinolines; D051844:alpha-Synuclein; D003300:Copper
keywords: chelates; copper; glycoconjugates; inhibitors; metal complexes