title: Combined maximum-quantum and DOSY 3D experiments provide enhanced resolution for small molecules in mixtures.
abstract: We illustrate here as the combination of high-order maximum-quantum (MaxQ) and Diffusion-Ordered SpectroscopY (DOSY) NMR experiments in a 3D layout allows superior resolution for crowded NMR spectra. Non-uniform sampling (NUS) allows compressing the experimental time effectively to reasonable durations. Because diffusion effects were encoded within multiple-quantum coherences, increased sensitivity to magnetic field gradients is observed, requiring compensation for convection effects. The experiment was demonstrated on the spectra of a mix of small polyaromatic molecules. Specifically, in the case analyzed, the experiment provided an extreme simplification through the MaxQDOSY-MaxQ projection plane that presents one peak per molecule. Copyright © 2016 John Wiley & Sons, Ltd.
authors.affiliation: Institut de Chimie des Substances Naturelles, CNRS UPR 2301 Avenue de la Terrasse, 91190, Gif-sur-Yvette, France.
authors.forename: G N
authors.initials: GN
authors.lastname: Manjunatha Reddy
authors.affiliation: Aix-Marseille Université, CNRS, Centrale Marseille, Institut des Sciences Moleculaires de Marseille, (iSm2, UMR 7313), 13397, Marseille, France.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Yemloul
authors.affiliation: Institut de Chimie des Substances Naturelles, CNRS UPR 2301 Avenue de la Terrasse, 91190, Gif-sur-Yvette, France.|Aix-Marseille Université, CNRS, Centrale Marseille, Institut des Sciences Moleculaires de Marseille, (iSm2, UMR 7313), 13397, Marseille, France.
authors.forename: Stefano
authors.initials: S
authors.lastname: Caldarelli
keywords: 1H; DOSY; NMR; mixtures; multiple-quantum; non-uniform sampling (NUS)