title: Brain Metabolic Changes of Cervical Dystonia with Spinocerebellar Ataxia Type 1 after Botulinum Toxin Therapy.
abstract: We occasionally observe long-term remission of cervical dystonia after several botulinum toxin treatments. However, botulinum toxin transiently acts on neuromuscular junctions. We herein report that a cervical dystonia patient with spinocerebellar ataxia type 1 could have long-term remission as a result of the depression of hypermetabolism in the bilateral putamen and primary sensorimotor cortex after botulinum toxin therapy. We suggest that botulinum toxin impacts the central nervous system, causing prolonged improvement through the normalization of basal ganglia circuits in addition to its effects at neuromuscular junctions.
authors.affiliation: Department of Neurology, Tohoku University Graduate School of Medicine, Japan.
authors.forename: Akio
authors.initials: A
authors.lastname: Kikuchi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takeda
authors.forename: Naoto
authors.initials: N
authors.lastname: Sugeno
authors.forename: Emiko
authors.initials: E
authors.lastname: Miura
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kato
authors.forename: Takafumi
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Toru
authors.initials: T
authors.lastname: Baba
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Konno
authors.forename: Ryuji
authors.initials: R
authors.lastname: Oshima
authors.forename: Shoichi
authors.initials: S
authors.lastname: Watanuki
authors.forename: Kotaro
authors.initials: K
authors.lastname: Hiraoka
authors.forename: Manabu
authors.initials: M
authors.lastname: Tashiro
authors.forename: Masashi
authors.initials: M
authors.lastname: Aoki
mesh_terms: D000328:Adult; D019274:Botulinum Toxins, Type A / Q000009:adverse effects*; D001921:Brain / Q000378:metabolism*; D004421:Dystonia; D006801:Humans; D008297:Male; D009465:Neuromuscular Agents / Q000009:adverse effects*; D020754:Spinocerebellar Ataxias / Q000139:chemically induced*; D014103:Torticollis / Q000139:chemically induced*
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A