title: Cytocompatibility of HeLa Cells to Nano-Sized Ceramics Particles.
abstract: In this study, we investigated the behaviors and cytocompatibility response of human cervical carcinoma (HeLa) cells expose to nano-sized particles. Cultivated cells exposed to titanium oxide and indium oxide nanoparticles remained highly viable. In the presence of copper oxide (CuO); however, the cells became seriously inflamed. To understand the mechanism by which CuO causes cell death, we evaluated cell death and apoptosis cytometry. CuO induced cells apoptosis more strongly than exposure to titania nanoparticles. Confocal fluorescence microscopy revealed that the nano-sized particles penetrate the cells.
authors.forename: Eri
authors.initials: E
authors.lastname: Seitoku
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Abe
authors.forename: Teruo
authors.initials: T
authors.lastname: Kusaka
authors.forename: Mariko
authors.initials: M
authors.lastname: Nakamura
authors.forename: Satoshi
authors.initials: S
authors.lastname: Inoue
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Sano
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects*; D002516:Ceramics / Q000737:chemistry* / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D006367:HeLa Cells; D006801:Humans; D008422:Materials Testing; D053758:Nanoparticles / Q000737:chemistry* / Q000633:toxicity* / Q000648:ultrastructure; D018675:Toxicity Tests