title: WNT Signaling in Cutaneous Squamous Cell Carcinoma: A Future Treatment Strategy?
abstract: The molecular mechanisms underlying cutaneous squamous cell carcinoma are less well established than those for other common skin cancers, but recent evidence has highlighted a potentially critical role for WNT signaling in both the development and progression of cutaneous squamous cell carcinoma. WNT pathways are aberrantly regulated in multiple tumor types (albeit in a context-dependent manner), and this has stimulated the development of WNT inhibitory compounds for cancer treatment. In this review, we examine existing evidence for a role of WNT signaling in cutaneous squamous cell carcinoma and discuss if WNT inhibition represents a realistic therapeutic strategy for the future.
authors.affiliation: Division of Cancer Research, School of Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK. Electronic address: v.sherwood@dundee.ac.uk.
authors.forename: Victoria
authors.initials: V
authors.lastname: Sherwood
authors.affiliation: Division of Cancer Research, School of Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
authors.forename: Irene M
authors.initials: IM
authors.lastname: Leigh
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology; D005544:Forecasting; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods / Q000639:trends*; D018570:Risk Assessment; D012878:Skin Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology; D016896:Treatment Outcome; D060449:Wnt Signaling Pathway / Q000235:genetics*