title: Genetics of non-alcoholic fatty liver disease: From susceptibility and nutrient interactions to management.
abstract: Genetics plays an important role in determining the susceptibility of an individual to develop a disease. Complex, multi factorial diseases of modern day (diabetes, cardiovascular disease, hypertension and obesity) are a result of disparity between the type of food consumed and genes, suggesting that food which does not match the host genes is probably one of the major reasons for developing life style diseases. Non-alcoholic fatty liver is becoming a global epidemic leading to substantial morbidity. While various genotyping approaches such as whole exome sequencing using next generation sequencers and genome wide association studies have identified susceptibility loci for non-alcoholic fatty liver disease (NAFLD) including variants in patatin-like phospholipase domain containing 3 and transmembrane 6 superfamily member 2 genes apart from others; nutrient based studies emphasized on a combination of vitamin D, E and omega-3 fatty acids to manage fatty liver disease. However majority of the studies were conducted independent of each other and very few studies explored the interactions between the genetic susceptibility and nutrient interactions. Identifying such interactions will aid in optimizing the nutrition tailor made to an individual's genetic makeup, thereby aiding in delaying the onset of the disease and its progression. The present topic focuses on studies that identified the genetic susceptibility for NAFLD, nutritional recommendations, and their interactions for better management of NAFLD.
authors.affiliation: Vishnubhotla Venkata Ravi Kanth, Mitnala Sasikala, Asian Healthcare Foundation, a Research Wing of Asian Institute of Gastroenterology, Hyderabad 500082, Telangana, India.
authors.forename: Vishnubhotla Venkata
authors.initials: VV
authors.lastname: Ravi Kanth
authors.affiliation: Vishnubhotla Venkata Ravi Kanth, Mitnala Sasikala, Asian Healthcare Foundation, a Research Wing of Asian Institute of Gastroenterology, Hyderabad 500082, Telangana, India.
authors.forename: Mitnala
authors.initials: M
authors.lastname: Sasikala
authors.affiliation: Vishnubhotla Venkata Ravi Kanth, Mitnala Sasikala, Asian Healthcare Foundation, a Research Wing of Asian Institute of Gastroenterology, Hyderabad 500082, Telangana, India.
authors.forename: Mithun
authors.initials: M
authors.lastname: Sharma
authors.affiliation: Vishnubhotla Venkata Ravi Kanth, Mitnala Sasikala, Asian Healthcare Foundation, a Research Wing of Asian Institute of Gastroenterology, Hyderabad 500082, Telangana, India.
authors.forename: Padaki Nagaraja
authors.initials: PN
authors.lastname: Rao
authors.affiliation: Vishnubhotla Venkata Ravi Kanth, Mitnala Sasikala, Asian Healthcare Foundation, a Research Wing of Asian Institute of Gastroenterology, Hyderabad 500082, Telangana, India.
authors.forename: Duvvuru Nageshwar
authors.initials: DN
authors.lastname: Reddy
keywords: Genetic susceptibility; Genotyping; Non-alcoholic fatty liver disease; Nutrient interactions; Patatin-like phospholipase domain containing 3 gene; Transmembrane 6 superfamily member 2 gene