title: Graphene Oxide and Gadolinium-Chelate Functionalized Poly(lactic acid) Nanocapsules Encapsulating Perfluorooctylbromide for Ultrasound/Magnetic Resonance Bimodal Imaging Guided Photothermal Ablation of Cancer.
abstract: This paper successfully fabricated a novel multifunctional theranostic agent (PFOB@PLA/GO/Gd-DTPA NCs) by loading perfluorooctylbromide (PFOB) into poly(lactic acid) (PLA) nanocapsules (NCs) followed by surface functionalization with graphene oxide (GO) and gadolinium-chelate (Gd-DTPA). It was found that the resulting nanoagent could serve as a contrast agent simultaneously to enhance ultrasound (US) and magnetic resonance imaging (MRI). Benefiting from the strong absorption in the near infrared (NIR) region, the nanocapsules could efficiently kill cancer cells under NIR laser irradiation. Thus, such a single theranostic agent with the combination of realtime US imaging and high-resolution MR imaging could achieve great therapeutic effectiveness without systemic damage to the body. In addition, the cytotoxicity assay on HUVEC cells revealed a good biocompatibility of PFOB@PLA/GO/Gd-DTPA NCs, showing that the versatile nanocapsule system may hold great potential as an effective nanoplatform for contrast enhanced imaging guided photothermal therapy.
authors.forename: Zhenglin
authors.initials: Z
authors.lastname: Li
authors.forename: Hengte
authors.initials: H
authors.lastname: Ke
authors.forename: Jinrui
authors.initials: J
authors.lastname: Wang
authors.forename: Zhaohua
authors.initials: Z
authors.lastname: Miao
authors.forename: Xiuli
authors.initials: X
authors.lastname: Yue
mesh_terms: D001672:Biocompatible Materials; D002614:Chelating Agents / Q000737:chemistry*; D005466:Fluorocarbons / Q000008:administration & dosage* / Q000737:chemistry; D005682:Gadolinium / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D006367:HeLa Cells; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D006842:Hydrocarbons, Brominated; D006979:Hyperthermia, Induced; D019344:Lactic Acid / Q000737:chemistry*; D008279:Magnetic Resonance Imaging / Q000379:methods; D053769:Nanocapsules; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D010087:Oxides / Q000737:chemistry; D010789:Phototherapy; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D014463:Ultrasonography / Q000379:methods
chemical_list: D001672:Biocompatible Materials; D002614:Chelating Agents; D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; D053769:Nanocapsules; D010087:Oxides; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D006108:Graphite; D005682:Gadolinium; C003072:perflubron