title: Prognostic impact of MYH9 expression on patients with acute myeloid leukemia.
abstract: MYH9 expression has previously been demonstrated as an independent predictor of clinical outcome in solid tumors. However, the prognostic relevance of MYH9 expression in acute myeloid leukemia is still unclear. Here, we found high MYH9 expressers were seen more frequently in females and more frequently in M4 morphology. We also found high MYH9 expressers had lower percentage of bone marrow blasts. In addition, overexpression of MYH9 was associated with an inferior overall survival. Notably, distinct microRNA signatures were seen in high MYH9 expressers. These results were also validated in an independent cohort of AML patients using the published data. In conclusion, gene of MYH9 expression might serve as a reliable predictor for overall survival in AML patients.
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China.|Institute of Hematology, Zhejiang University, Hangzhou, China.|Key Laboratory of Hematologic Malignancies, Diagnosis and Treatment, Zhejiang, Hangzhou, China.
authors.forename: Mengxia
authors.initials: M
authors.lastname: Yu
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China.|Institute of Hematology, Zhejiang University, Hangzhou, China.|Key Laboratory of Hematologic Malignancies, Diagnosis and Treatment, Zhejiang, Hangzhou, China.
authors.forename: Jinghan
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China.|Institute of Hematology, Zhejiang University, Hangzhou, China.|Key Laboratory of Hematologic Malignancies, Diagnosis and Treatment, Zhejiang, Hangzhou, China.|Department of Hematology, Fujian Medical University Union Hospital, Fuzhou, China.
authors.forename: Zhijuan
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China.|Institute of Hematology, Zhejiang University, Hangzhou, China.|Key Laboratory of Hematologic Malignancies, Diagnosis and Treatment, Zhejiang, Hangzhou, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Hu
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China.|Institute of Hematology, Zhejiang University, Hangzhou, China.|Key Laboratory of Hematologic Malignancies, Diagnosis and Treatment, Zhejiang, Hangzhou, China.|Department of Hematology, The Second Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, China.
authors.forename: Qiuling
authors.initials: Q
authors.lastname: Ma
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China.|Institute of Hematology, Zhejiang University, Hangzhou, China.|Key Laboratory of Hematologic Malignancies, Diagnosis and Treatment, Zhejiang, Hangzhou, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China.|Institute of Hematology, Zhejiang University, Hangzhou, China.|Key Laboratory of Hematologic Malignancies, Diagnosis and Treatment, Zhejiang, Hangzhou, China.
authors.forename: Xiufeng
authors.initials: X
authors.lastname: Yin
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China.|Institute of Hematology, Zhejiang University, Hangzhou, China.|Key Laboratory of Hematologic Malignancies, Diagnosis and Treatment, Zhejiang, Hangzhou, China.
authors.forename: Jiansong
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China.|Institute of Hematology, Zhejiang University, Hangzhou, China.|Key Laboratory of Hematologic Malignancies, Diagnosis and Treatment, Zhejiang, Hangzhou, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China.|Institute of Hematology, Zhejiang University, Hangzhou, China.|Key Laboratory of Hematologic Malignancies, Diagnosis and Treatment, Zhejiang, Hangzhou, China.
authors.forename: Zhixin
authors.initials: Z
authors.lastname: Ma
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China.|Institute of Hematology, Zhejiang University, Hangzhou, China.|Key Laboratory of Hematologic Malignancies, Diagnosis and Treatment, Zhejiang, Hangzhou, China.
authors.forename: Yile
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China.|Institute of Hematology, Zhejiang University, Hangzhou, China.|Key Laboratory of Hematologic Malignancies, Diagnosis and Treatment, Zhejiang, Hangzhou, China.
authors.forename: Chenying
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China.|Institute of Hematology, Zhejiang University, Hangzhou, China.|Key Laboratory of Hematologic Malignancies, Diagnosis and Treatment, Zhejiang, Hangzhou, China.
authors.forename: Feifei
authors.initials: F
authors.lastname: Chen
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China.|Institute of Hematology, Zhejiang University, Hangzhou, China.|Key Laboratory of Hematologic Malignancies, Diagnosis and Treatment, Zhejiang, Hangzhou, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China.|Institute of Hematology, Zhejiang University, Hangzhou, China.|Key Laboratory of Hematologic Malignancies, Diagnosis and Treatment, Zhejiang, Hangzhou, China.
authors.forename: Yungui
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China.|Institute of Hematology, Zhejiang University, Hangzhou, China.|Key Laboratory of Hematologic Malignancies, Diagnosis and Treatment, Zhejiang, Hangzhou, China.
authors.forename: Hanzhang
authors.initials: H
authors.lastname: Pan
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China.|Institute of Hematology, Zhejiang University, Hangzhou, China.|Key Laboratory of Hematologic Malignancies, Diagnosis and Treatment, Zhejiang, Hangzhou, China.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China.|Institute of Hematology, Zhejiang University, Hangzhou, China.|Key Laboratory of Hematologic Malignancies, Diagnosis and Treatment, Zhejiang, Hangzhou, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Jin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001853:Bone Marrow / Q000473:pathology; D015331:Cohort Studies; D020732:Cytogenetic Analysis; D004252:DNA Mutational Analysis; D005260:Female; D015870:Gene Expression; D020869:Gene Expression Profiling; D006801:Humans; D053208:Kaplan-Meier Estimate; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics* / Q000401:mortality*; D008297:Male; D035683:MicroRNAs / Q000235:genetics; D008875:Middle Aged; D020409:Molecular Motor Proteins / Q000235:genetics*; D009154:Mutation; D018995:Myosin Heavy Chains / Q000235:genetics*; D011379:Prognosis; D055815:Young Adult
chemical_list: C103814:MYH9 protein, human; D035683:MicroRNAs; D020409:Molecular Motor Proteins; D018995:Myosin Heavy Chains
keywords: MYH9; acute myeloid leukemia; prognosis