title: Predictors of Lesion Calcification in Patients with Solitary Cysticercus Granuloma and New-Onset Seizures.
abstract: Solitary cysticercus granuloma is a common neuroimaging abnormality in Indian patients with new-onset epilepsy. Calcific transformation of cysticercus granuloma is frequently associated with seizure recurrence. We evaluated predictors of lesion calcification in patients with solitary cysticercus granuloma and new-onset seizures. One hundred twenty-two patients, with new-onset seizures and a solitary cysticercus granuloma of the brain, were enrolled. All patients were clinically and radiologically evaluated and were treated with antiepileptic drug drugs. No patient received albendazole or corticosteroids. The follow-up period was of 1 year. Follow-up computed tomography was performed after 3 and 6 months. In 68 (54.8%) patients, solitary cysticercus granuloma had transformed into a calcified lesion. On logistic regression analysis, moderate-to-severe edema was a significant factor that predicted calcific transformation of the cysticercus granuloma (odds ratio: 3.325; 95% confidence interval: 1.502-7.362). During 1 year of follow-up, 19 (15.6%) patients experienced seizure recurrence. In 16 patients with seizure recurrence, cysticercus granuloma had transformed in to a calcified lesion. In conclusion, in solitary cysticercus granuloma, calcification of the lesion can be predicted if larger amount of perilesional edema is present. Calcification of the granuloma significantly predicts seizure recurrence.
authors.affiliation: Department of Neurology, King George Medical University, Uttar Pradesh, Lucknow, India.
authors.forename: Lalit
authors.initials: L
authors.lastname: Mahajan
authors.affiliation: Department of Neurology, King George Medical University, Uttar Pradesh, Lucknow, India.
authors.forename: Hardeep Singh
authors.initials: HS
authors.lastname: Malhotra
authors.affiliation: Department of Neurology, King George Medical University, Uttar Pradesh, Lucknow, India. garg50@yahoo.com.
authors.forename: Ravindra Kumar
authors.initials: RK
authors.lastname: Garg
authors.affiliation: Department of Neurology, King George Medical University, Uttar Pradesh, Lucknow, India.
authors.forename: Neeraj
authors.initials: N
authors.lastname: Kumar
authors.affiliation: Department of Neurology, King George Medical University, Uttar Pradesh, Lucknow, India.
authors.forename: Praveen Kumar
authors.initials: PK
authors.lastname: Sharma
authors.affiliation: Department of Neurology, King George Medical University, Uttar Pradesh, Lucknow, India.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Verma
authors.affiliation: Department of Neurology, King George Medical University, Uttar Pradesh, Lucknow, India.
authors.forename: Imran
authors.initials: I
authors.lastname: Rizvi
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use; D002114:Calcinosis / Q000209:etiology / Q000469:parasitology*; D003552:Cysticercus; D005260:Female; D006099:Granuloma / Q000209:etiology / Q000469:parasitology*; D006801:Humans; D007194:India; D008297:Male; D020019:Neurocysticercosis / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology*; D059906:Neuroimaging; D011446:Prospective Studies; D012008:Recurrence; D012307:Risk Factors; D012640:Seizures / Q000188:drug therapy / Q000209:etiology / Q000469:parasitology* / Q000473:pathology; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D000927:Anticonvulsants