title: Protective Effect of Zingiber officinale Against Dalton's Lymphoma Ascites Tumour by Regulating Inflammatory Mediator and Cytokines.
abstract: The aim of the present investigation was to evaluate Zingiber officinale paste against Dalton's lymphoma ascites (DLA)-induced tumours in Swiss albino mice. Experimental animals received Z. officinale paste (low dose 100 mg/kg bw and high dose 500 mg/kg bw) orally for eight alternative days. Treatment with Z. officinale paste showed significant increase in haemoglobin level and decrease in aspartate amino transferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and gamma glutamyl transferase (γ-GT) level. Z. officinale paste reduced the inflammatory mediators and cytokine levels, such as inducible nitric oxide (iNOS), tumour necrosis factor level (TNF-α) and interleukin-1β (IL-1β). Treatment with Z. officinale paste also significantly increased the antioxidant enzyme level, such as superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) and glutathione transferase (GST), and decreased the lipid peroxidation. Treatment also increased the vitamin C and E levels in treated animals compared with the DLA-bearing host. Histopathological studies also confirmed the protective influence of Z. officinale paste against DLA. The present study suggested that Z. officinale paste could be used as natural spice and a potent antitumour agent.
authors.affiliation: Department of Food Processing and Engineering, School of Biotechnology and Health Sciences, Karunya University, Coimbatore, Tamilnadu, 641114, India.
authors.forename: Sundararaj
authors.initials: S
authors.lastname: Rubila
authors.affiliation: Department of Food Processing and Engineering, School of Biotechnology and Health Sciences, Karunya University, Coimbatore, Tamilnadu, 641114, India. ranganathan@karunya.edu.
authors.forename: Thottiam Vasudevan
authors.initials: TV
authors.lastname: Ranganathan
authors.affiliation: Department of Biotechnology, School of Biotechnology and Health Sciences, Karunya University, Coimbatore, Tamilnadu, 641114, India.
authors.forename: Kunnathur Murugesan
authors.initials: KM
authors.lastname: Sakthivel
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001201:Ascites / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D001205:Ascorbic Acid / Q000097:blood; D014408:Biomarkers, Tumor / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism*; D008401:Gas Chromatography-Mass Spectrometry; D020939:Zingiber officinale / Q000737:chemistry*; D005978:Glutathione / Q000378:metabolism; D005982:Glutathione Transferase / Q000097:blood; D018836:Inflammation Mediators / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D008223:Lymphoma / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D020011:Protective Agents / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D014408:Biomarkers, Tumor; D016207:Cytokines; D018836:Inflammation Mediators; D010936:Plant Extracts; D020011:Protective Agents; D005982:Glutathione Transferase; D005978:Glutathione; D001205:Ascorbic Acid
keywords: 6-gingerol; Antioxidant enzymes; Antitumour; Cytokines; GC-MS; Zingiber officinale paste