title: First Report of German Cockroaches (Blattella germanica) as Reservoirs of CTX-M-15 Extended-Spectrum-β-Lactamase- and OXA-48 Carbapenemase-Producing Enterobacteriaceae in Batna University Hospital, Algeria.
abstract: Here we report the isolation of extended-spectrum β-lactamase (ESBL)- and carbapenemase-producing Enterobacteriaceae from German cockroaches caught in the burn unit of Batna University Hospital in Algeria. Nine of 12 isolates harbored the blaCTX-M-15 ESBL gene. One Enterobacter cloacae isolate belonging to sequence type 528 coexpressed the blaOXA-48, blaCTX-M-15, and blaTEM genes. Our findings indicate that cockroaches may be one of the most dangerous reservoirs for ESBL and carbapenemase producers in hospitals.
authors.affiliation: Laboratoire de Biotechnologie des Molécules Bioactives et de la Physiopathologie Cellulaire (LBMBPC), Faculté des Sciences de la Nature et de la Vie, Université de Batna 2, Batna, Algeria Unité de Recherche sur les Maladies Infectieuses et Tropicales Émergentes (URMITE), UM 63, CNRS 7278, IRD 198, INSERM 1095, IHU Méditérranée Infection, Faculté de Médecine et de Pharmacie, Aix-Marseille-Université, Marseille, France.
authors.forename: Lotfi
authors.initials: L
authors.lastname: Loucif
authors.affiliation: Département de Biochimie, Faculté des Sciences, Université Badji Mokhtar Annaba, Annaba, Algeria.
authors.forename: Djamila
authors.initials: D
authors.lastname: Gacemi-Kirane
authors.affiliation: Laboratoire de Biotechnologie des Molécules Bioactives et de la Physiopathologie Cellulaire (LBMBPC), Faculté des Sciences de la Nature et de la Vie, Université de Batna 2, Batna, Algeria.
authors.forename: Zineb
authors.initials: Z
authors.lastname: Cherak
authors.affiliation: Laboratoire de Biotechnologie des Molécules Bioactives et de la Physiopathologie Cellulaire (LBMBPC), Faculté des Sciences de la Nature et de la Vie, Université de Batna 2, Batna, Algeria.
authors.forename: Naima
authors.initials: N
authors.lastname: Chamlal
authors.affiliation: Faculté de Médecine, Université de Batna 2, Batna, Algeria.
authors.forename: Nadia
authors.initials: N
authors.lastname: Grainat
authors.affiliation: Unité de Recherche sur les Maladies Infectieuses et Tropicales Émergentes (URMITE), UM 63, CNRS 7278, IRD 198, INSERM 1095, IHU Méditérranée Infection, Faculté de Médecine et de Pharmacie, Aix-Marseille-Université, Marseille, France jean-marc.rolain@univ-amu.fr.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Rolain
mesh_terms: D000462:Algeria; D000818:Animals; D003058:Cockroaches / Q000382:microbiology*; D004197:Disease Reservoirs; D016972:Enterobacter cloacae / Q000235:genetics; D004755:Enterobacteriaceae / Q000235:genetics* / Q000302:isolation & purification*; D006785:Hospitals, University; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism
chemical_list: C473109:beta-lactamase CTX-M-15; D001618:beta-Lactamases