title: Comparative Analysis of GCF Resistin Levels in Obese Subjects with and without Periodontal Disease.
abstract: BACKGROUND
  Resistin is an adipocyte derived hormone that has been shown to play a substantial role in the development of insulin resistance. Resistin acts as a pro-inflammatory molecule and stimulates the synthesis and secretion of pro-inflammatory cytokines. Recent studies have reported the association of Gingival Crevicular Fluid (GCF) resistin levels with periodontal condition.
  
  
  OBJECTIVE
  The aim of this study was to assess and compare the GCF resistin levels in obese subjects with periodontal health and disease and to correlate the disease severity with GCF resistin levels.
  
  
  METHODS
  Ninety subjects of both the sexes with age between 20-45 years were selected for the study and were categorized into four groups: 25 obese or overweight subjects with generalized chronic periodontitis (Group-I), 25 obese or overweight subjects with healthy periodontium (Group-II), 25 non-obese subjects with generalized chronic periodontitis (Group-III) and 15 non obese subjects with healthy periodontium (Group-IV). The demographic variables like age, Body Mass Index (BMI), Waist Circumference (WC) were recorded and the clinical periodontal parameters such as Plaque Index (PI), Gingival Index (GI), and Clinical Attachment Level (CAL) were also assessed in all the groups. GCF was collected and assessed for resistin levels.
  
  
  RESULTS
  The mean GCF resistin levels in Groups I, II, III & IV were 15.14, 9.06, 12.74 and 5.41 ng/dl respectively and the difference in mean GCF resistin level was statistically significant with the p-value<0.001. The mean GCF resistin levels in Group-I was higher compared to Group II and III and the differences in mean GCF resistin levels were statistically significant. GCF resistin levels were positively correlated with BMI, WC and CAL in Group I and CAL correlated with GCF resistin in Group III and this correlation was statistically significant.
  
  
  CONCLUSIONS
  From our study we report that obese subjects with periodontitis have more GCF resistin levels compared to non-obese subjects with healthy periodontium.
authors.affiliation: Professor, Department of Periodontics, Thaimoogambigai Dental College , Chennai, India .
authors.forename: Snophia
authors.initials: S
authors.lastname: Suresh
authors.affiliation: Professor, Department of Periodontics, Meenakshiammal Dental College , Chennai, India .
authors.forename: Jaideep
authors.initials: J
authors.lastname: Mahendra
authors.affiliation: Professor, Department of Periodontics, Sree Balaji Dental College , Chennai, India .
authors.forename: Gurdeep
authors.initials: G
authors.lastname: Singh
authors.affiliation: Professor and Head, Department of Conservative Dentistry, Thaimoogambigai Dental College , Chennai, India .
authors.forename: A R
authors.initials: AR
authors.lastname: Pradeep
authors.affiliation: Post Graduate Student, Department of Periodontics, Thaimoogambigai Dental College , Chennai, India .
authors.lastname: Sundaravikram
authors.affiliation: Post Graduate Student, Department of Periodontics, Thaimoogambigai Dental College , Chennai, India .
authors.forename: Himanshu
authors.initials: H
authors.lastname: Sekar
keywords: Adiposity; ELISA; Periodontal disease