title: Study of the Peripheral Nerve Fibers Myelin Structure Changes during Activation of Schwann Cell Acetylcholine Receptors.
abstract: In the present paper we consider a new type of mechanism by which neurotransmitter acetylcholine (ACh) regulates the properties of peripheral nerve fibers myelin. Our data show the importance of the relationship between the changes in the number of Schwann cell (SC) acetylcholine receptors (AChRs) and the axon excitation (different intervals between action potentials (APs)). Using Raman spectroscopy, an effect of activation of SC AChRs on the myelin membrane fluidity was investigated. It was found, that ACh stimulates an increase in lipid ordering degree of the myelin lipids, thus providing evidence for specific role of the "axon-SC" interactions at the axon excitation. It was proposed, that during the axon excitation, the SC membrane K+- depolarization and the Ca2+-influx led to phospholipase activation or exocytosis of intracellular membrane vesicles and myelin structure reorganization.
authors.affiliation: Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia.
authors.forename: Ekaterina E
authors.initials: EE
authors.lastname: Verdiyan
authors.affiliation: Faculty of Fundamental Medicine, M.V. Lomonosov Moscow State University, Moscow, Russia.
authors.forename: Elvin S
authors.initials: ES
authors.lastname: Allakhverdiev
authors.affiliation: Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia.|Faculty of Fundamental Medicine, M.V. Lomonosov Moscow State University, Moscow, Russia.
authors.forename: Georgy V
authors.initials: GV
authors.lastname: Maksimov
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001001:Anura; D001369:Axons; D007553:Isotope Labeling; D008055:Lipids / Q000737:chemistry; D008297:Male; D009186:Myelin Sheath / Q000737:chemistry / Q000378:metabolism*; D009413:Nerve Fibers, Myelinated / Q000737:chemistry / Q000378:metabolism; D010525:Peripheral Nerves; D011485:Protein Binding; D011950:Receptors, Cholinergic / Q000378:metabolism*; D012583:Schwann Cells / Q000378:metabolism*; D013059:Spectrum Analysis, Raman
chemical_list: D008055:Lipids; D011950:Receptors, Cholinergic; D000109:Acetylcholine