title: Relation between amount of bile ducts in portal canal and outcomes in biliary atresia.
abstract: BACKGROUND
  There is no good prognostic indicator for biliary atresia (BA). We reviewed liver biopsies taken during the initial procedure to find a prognostic marker.
  
  
  METHODS
  Thirty-two BA cases underwent Kasai operation from 1976 to 2009. We compared two groups at 1, 3, and 9 years. Group A required liver transplantation or died. Group B survived with their native liver. Biopsies were analyzed for liver fibrosis, portal-central vein bridging (P-C bridging), ductal plate malformation (DPM) and the number of the bile ducts in portal canal/measured surface area of the portal canal (BDP ratio). Statistical comparisons of the multiple data were evaluated by Mann-Whitney U test, Student's t test and Pearson's Chi-square test. Regression analysis with P < 0.05 was considered significant.
  
  
  RESULTS
  BDP ratios (/mm(2)) were 2.4 ± 1.5 in Group A1 (n = 9) vs 4.6 ± 2.4 in Group B1 (n = 23) (P = 0.01); 2.6 ± 1.4 in Group A3 (n = 14) vs 5.1 ± 2.5 in Group B3 (n = 18) (P < 0.01), 3.0 ± 2.2 in Group A9 (n = 15) vs 4.9 ± 2.5 in Group B9 (n = 15) (P < 0.05). There was no significant difference in any other finding.
  
  
  CONCLUSIONS
  The BDP ratio is a sound prognostic indicator in BA.
authors.affiliation: Division of Pediatric Surgery, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae, Kawasaki, Kanagawa, 216-8511, Japan.
authors.forename: Juma
authors.initials: J
authors.lastname: Obayashi
authors.affiliation: Division of Pediatric Surgery, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae, Kawasaki, Kanagawa, 216-8511, Japan.
authors.forename: Kunihide
authors.initials: K
authors.lastname: Tanaka
authors.affiliation: Division of Pediatric Surgery, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae, Kawasaki, Kanagawa, 216-8511, Japan.
authors.forename: Kei
authors.initials: K
authors.lastname: Ohyama
authors.affiliation: Division of Pediatric Surgery, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae, Kawasaki, Kanagawa, 216-8511, Japan.
authors.forename: Shutaro
authors.initials: S
authors.lastname: Manabe
authors.affiliation: Division of Pediatric Surgery, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae, Kawasaki, Kanagawa, 216-8511, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Nagae
authors.affiliation: Division of Pediatric Surgery, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae, Kawasaki, Kanagawa, 216-8511, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Shima
authors.affiliation: Division of Pediatric Surgery, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae, Kawasaki, Kanagawa, 216-8511, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Sato
authors.affiliation: Division of Pediatric Surgery, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae, Kawasaki, Kanagawa, 216-8511, Japan.
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Furuta
authors.affiliation: Division of Pediatric Surgery, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae, Kawasaki, Kanagawa, 216-8511, Japan.
authors.forename: Munechika
authors.initials: M
authors.lastname: Wakisaka
authors.affiliation: Department of Pathology, St. Marianna University School of Medicine, Kawasaki, Japan.
authors.forename: Junki
authors.initials: J
authors.lastname: Koike
authors.affiliation: Department of Pathology, St. Marianna University School of Medicine, Kawasaki, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Takagi
authors.affiliation: Division of Pediatric Surgery, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae, Kawasaki, Kanagawa, 216-8511, Japan. h2kita@marianna-u.ac.jp.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kitagawa
mesh_terms: D001652:Bile Ducts / Q000473:pathology*; D001656:Biliary Atresia / Q000401:mortality / Q000601:surgery*; D001706:Biopsy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008103:Liver Cirrhosis / Q000473:pathology; D016031:Liver Transplantation; D008297:Male; D011379:Prognosis
keywords: Bile ducts in portal canal; Biliary atresia; Liver fibrosis