title: An angle-supported foldable phakic intraocular lens for correction of myopia: A five-year follow-up.
abstract: OBJECTIVE
  To evaluate the efficacy and safety of an angle-supported foldable phakic intraocular lens (pIOL) for the correction of moderate to high myopia after 5 years follow-up.
  
  
  METHODS
  Prospective and retrospective, observational, longitudinal, non-randomised consecutive series of cases conducted on a total of 100 eyes of 67 patients with moderate to high myopia implanted with an Acrysof Cachet pIOL (Alcon Laboratories Inc.) with the aim of minimising the refractive error. The ages ranged between 18 to 60years. Uncorrected distance visual acuity (UDVA), manifest refraction, corrected distance visual acuity (CDVA), endothelial cells density, pIOL position, intraocular pressure, and complications were recorded preoperatively and during the 5 year follow-up.
  
  
  RESULTS
  Five years after implantation, the mean manifest spherical equivalent refraction reduced significantly from -11.62±3.35 dioptres (D) to -0.33±0.85D. UDVA was 20/20 or better in 5 of 25 cases (20%), and 20/40 or better in 22 cases (88%). CDVA was 20/20 or better in 17 cases (68%), and 20/32 or better in 23 cases (92%) of eyes. The residual refractive error was within ±0.50D of emmetropia in 12 cases (48%), and within ±1.00D in 19 cases (76%). Mean endothelial cell loss at 5 years was 11.8% central, and 13.7% peripheral. Mean endothelium-pIOL distance was 2.11±0.18mm, and mean pIOL-crystalline distance was 0.88±0.20mm.
  
  
  CONCLUSIONS
  This angle supported pIOL provided a favourable refractive correction and predictability, as well as acceptable safety in patients with moderate to high myopia. Although endothelial cell density decreased over 5years, the results are within the range reported in previous studies with other pIOLs.
authors.affiliation: Vissum Alicante, Departamento de Investigación, Desarrollo e Innovación, Alicante, España; División de Oftalmología, Departamento de Patología y Cirugía, Universidad Miguel Hernández, Alicante, España. Electronic address: jlalio@vissum.com.
authors.forename: J L
authors.initials: JL
authors.lastname: Alió
authors.affiliation: Vissum Alicante, Departamento de Investigación, Desarrollo e Innovación, Alicante, España.
authors.forename: A B
authors.initials: AB
authors.lastname: Plaza-Puche
authors.affiliation: Departamento de Expresión Gráfica, Universidad Politécnica de Cartagena, Cartagena, Murcia, España.
authors.forename: F
authors.initials: F
authors.lastname: Cavas
authors.affiliation: Vissum Alicante, Departamento de Investigación, Desarrollo e Innovación, Alicante, España.
authors.forename: P
authors.initials: P
authors.lastname: Yébana Rubio
authors.affiliation: Vissum Alicante, Departamento de Investigación, Desarrollo e Innovación, Alicante, España.
authors.forename: E
authors.initials: E
authors.lastname: Sala
mesh_terms: D000293:Adolescent; D000328:Adult; D004728:Endothelium, Corneal / Q000648:ultrastructure; D004867:Equipment Design; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D019654:Lens Implantation, Intraocular; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000601:surgery*; D054120:Phakic Intraocular Lenses; D018583:Pliability; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology; D011446:Prospective Studies; D012029:Refraction, Ocular; D012030:Refractive Errors; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D014792:Visual Acuity; D055815:Young Adult
keywords: Densidad de células endoteliales; Efficacy; Eficacia; Endothelial cell density; Lente intraocular fáquica; Long term follow-up; Phakic intraocular lens; Resultados visuales; Safety; Seguimiento a largo plazo; Seguridad; Visual outcomes