title: Prediction of radioactive iodine remnant ablation failure in patients with differentiated thyroid cancer: A cohort study of 740 patients.
abstract: The purpose of this study was to detect parameters that could serve as predictors of radioactive iodine (I-131) ablation failure in patients with low-risk and intermediate-risk differentiated thyroid carcinoma (DTC).
  
  
  
  Our cohort study included 740 patients with DTC who received postoperative I-131 remnant ablation. Anthropometric, biochemical, and pathohistological parameters were analyzed and correlated with ablation outcome using multivariable logistic regression models.
  
  
  
  Treatment failure rates were higher in patients <53 years, with N1a classification, and lymph node capsular invasion. In patients with N1a disease, thyroglobulin (Tg) > 2.4 ng/mL predicted treatment failure with 93.8% sensitivity and 52.5% specificity, and in patients with N1b disease, Tg > 14.9 ng/mL with 77.8% sensitivity and 92.9% specificity. I-131 activity was not associated with treatment outcome.
  
  
  
  Patients < 53 years old, with higher Tg levels, N1a classification, and lymph node capsular invasion have a higher risk of ablation failure. Stimulated Tg is an excellent predictor of treatment failure in patients with N1 disease. © 2016 Wiley Periodicals, Inc. Head Neck 39: 109-115, 2017.
authors.affiliation: Department of Oncology and Nuclear Medicine University Hospital Center "Sestre milosrdnice,", Vinogradska cesta 29, 10000, Zagreb, Croatia.
authors.forename: Marin
authors.initials: M
authors.lastname: Prpic
authors.affiliation: Department of Oncology and Nuclear Medicine University Hospital Center "Sestre milosrdnice,", Vinogradska cesta 29, 10000, Zagreb, Croatia.
authors.forename: Davor
authors.initials: D
authors.lastname: Kust
authors.affiliation: Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolic Diseases "Mladen Sekso,", University Hospital Center "Sestre Milosrdnice,", Vinogradska cesta 29, 10000, Zagreb, Croatia.
authors.forename: Ivan
authors.initials: I
authors.lastname: Kruljac
authors.affiliation: Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolic Diseases "Mladen Sekso,", University Hospital Center "Sestre Milosrdnice,", Vinogradska cesta 29, 10000, Zagreb, Croatia.
authors.forename: Lora Stanka
authors.initials: LS
authors.lastname: Kirigin
authors.affiliation: Department of Oncology and Nuclear Medicine University Hospital Center "Sestre milosrdnice,", Vinogradska cesta 29, 10000, Zagreb, Croatia.
authors.forename: Tomislav
authors.initials: T
authors.lastname: Jukic
authors.affiliation: Department of Oncology and Nuclear Medicine University Hospital Center "Sestre milosrdnice,", Vinogradska cesta 29, 10000, Zagreb, Croatia.
authors.forename: Nina
authors.initials: N
authors.lastname: Dabelic
authors.affiliation: Department of Oncology and Nuclear Medicine University Hospital Center "Sestre milosrdnice,", Vinogradska cesta 29, 10000, Zagreb, Croatia.
authors.forename: Ante
authors.initials: A
authors.lastname: Bolanca
authors.affiliation: Department of Oncology and Nuclear Medicine University Hospital Center "Sestre milosrdnice,", Vinogradska cesta 29, 10000, Zagreb, Croatia.
authors.forename: Zvonko
authors.initials: Z
authors.lastname: Kusic
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D002648:Child; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D018365:Neoplasm, Residual; D011237:Predictive Value of Tests; D012372:ROC Curve; D018714:Radiotherapy, Adjuvant; D012307:Risk Factors; D013964:Thyroid Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D013965:Thyroidectomy; D017211:Treatment Failure; D055815:Young Adult
chemical_list: D007457:Iodine Radioisotopes
keywords: I-131; predictive factors; radioactive iodine therapy; thyroglobulin; thyroid ablation failure; thyroid cancer