title: Pancreaticoduodenectomy outcomes in the pediatric, adolescent, and young adult population.
abstract: Pancreatic malignancy and chronic pancreatitis are rare in the pediatric, adolescent, and young adult (AYA) population, making pancreas resections an infrequent procedure in this demographic. Only case reports and small case series exist in the literature describing surgical outcomes and complications in this population. The aim of this study was to review the surgical outcomes of pediatric/AYA patients undergoing pancreaticoduodenectomy (PD) at our institution.
  
  
  
  All pediatric/AYA adult patients (≤30 years) undergoing PD over a 15-year period (1998-2013) from a large academic institution were included. We provide adult (>30 years) data from our same institution for observational comparison. Retrospective chart review was performed to identify pertinent preoperative, perioperative, and postoperative data.
  
  
  
  Twenty-two patients with a median age of 25 years (range, 11-30 years) underwent PD. The most common postoperative histologic diagnoses were chronic pancreatitis (6, 27.3%), solid pseudopapillary neoplasm (5, 22.7%), and adenocarcinoma (4, 18.2%). Complications were 31.8% in the pediatric/AYA cohort and 58.6% in the adult cohort. The most common postoperative complication was intraabdominal abscess, which occurred in three patients (13.6%). Thirty-day mortality was 0% for pediatric/AYA patients. There were no recurrences or disease-related deaths in patients with solid pseudopapillary neoplasm. Pediatric patients with adenocarcinoma had a median survival of 10.2 mo (interquartile range, 9-21), in contrast to adults of 57.8 mo (interquartile range, 11-132).
  
  
  
  This is the largest series of PD procedures reported in the pediatric/AYA population. The procedure appears to be safe, with no 30-day mortalities and an acceptable complication rate.
authors.affiliation: Department of General Surgery, The Ohio State University College of Medicine, Columbus, Ohio.
authors.forename: Sara A
authors.initials: SA
authors.lastname: Mansfield
authors.affiliation: Department of General Surgery, The Ohio State University College of Medicine, Columbus, Ohio.
authors.forename: Justin B
authors.initials: JB
authors.lastname: Mahida
authors.affiliation: Division of Surgical Oncology, Department of General Surgery, The Ohio State University College of Medicine, Columbus, Ohio.
authors.forename: Mary
authors.initials: M
authors.lastname: Dillhoff
authors.affiliation: Center for Biostatistics, The Ohio State University, Columbus, Ohio.
authors.forename: Kyle
authors.initials: K
authors.lastname: Porter
authors.affiliation: Center for Biostatistics, The Ohio State University, Columbus, Ohio.
authors.forename: Darwin
authors.initials: D
authors.lastname: Conwell
authors.affiliation: Division of Hematology and Oncology, and Bone Marrow Transplantation, Department of Pediatrics, The Ohio State University College of Medicine, Nationwide Children's Hospital, Columbus, Ohio.
authors.forename: Mark
authors.initials: M
authors.lastname: Ranalli
authors.affiliation: Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, College of Medicine, The Ohio State University College of Medicine, Columbus, Ohio.
authors.forename: Jon P
authors.initials: JP
authors.lastname: Walker
authors.affiliation: Division of Pediatric Surgery, Department of Surgery, The Ohio State University College of Medicine, Nationwide Children's Hospital, Columbus, Ohio. Electronic address: Jennifer.aldrink@nationwidechildrens.org.
authors.forename: Jennifer H
authors.initials: JH
authors.lastname: Aldrink
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D010182:Pancreatic Diseases / Q000401:mortality / Q000601:surgery*; D016577:Pancreaticoduodenectomy; D011183:Postoperative Complications / Q000453:epidemiology; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
keywords: Adolescent and young adult; Chronic pancreatitis; Outcomes; Pancreaticoduodenectomy; Pediatric; Solid pseudopapillary neoplasm