title: Gastric Polyp Growth during Endoscopic Surveillance for Esophageal Varices or Barrett's Esophagus.
abstract: BACKGROUND
  We recently observed patients with chronic liver disease (CLD) or chronic reflux symptoms (CRS) who developed gastric polyps (GPs) while undergoing surveillance gastroscopies for the detection of esophageal varices or Barrett's esophagus, respectively.
  
  
  OBJECTIVE
  To identify risk factors for GP growth and estimate its growth rate.
  
  
  METHODS
  GP growth rate was defined as the number of days since the first gastroscopy (without polyps) in the surveillance program, until the gastroscopy when a GP was discovered.
  
  
  RESULTS
  Gastric polyp growth rates in CLD and CRS patients were similar. However, hyperplastic gastric polyps (HGPs) were detected more often (87.5% vs. 60.5%, P = 0.051) and at a higher number (2.57 ± 1.33 vs. 1.65 ± 0.93, P = 0.021) in the CLD patients. Subgroup analysis revealed the following findings only in CLD patients with HGPs: (i) a positive correlation between the GP growth rate and the patient's age; the older the patient, the higher the GP growth rate (r = 0.7, P = 0.004). (ii) A negative correlation between the patient's age and the Ki-67 proliferation index value; the older the patient, the lower the Ki-67 value (r = -0.64, P = 0.02). No correlation was detected between Ki-67 values of HGPs in CLD patients and the presence of portal hypertension, infection with Helicobacter pylori, or proton pump inhibitor use.
  
  
  CONCLUSIONS
  In comparison with CRS patients, CLD patients developed HGPs more often and at a greater number. Young CLD patients may have a tendency to develop HGPs at a faster rate than elderly CLD patients.
authors.forename: Dan M
authors.initials: DM
authors.lastname: Livovsky
authors.forename: Orit
authors.initials: O
authors.lastname: Pappo
authors.forename: Galina
authors.initials: G
authors.lastname: Skarzhinsky
authors.forename: Asaf
authors.initials: A
authors.lastname: Peretz
authors.forename: Elliot
authors.initials: E
authors.lastname: Turvall
authors.forename: Zvi
authors.initials: Z
authors.lastname: Ackerman
mesh_terms: D018256:Adenomatous Polyps / Q000473:pathology / Q000503:physiopathology; D000367:Age Factors; D000368:Aged; D001471:Barrett Esophagus / Q000175:diagnosis / Q000209:etiology; D018450:Disease Progression; D004932:Esophageal and Gastric Varices / Q000175:diagnosis / Q000209:etiology; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications*; D005773:Gastroscopy / Q000379:methods*; D016481:Helicobacter Infections / Q000453:epidemiology; D006801:Humans; D007557:Israel / Q000453:epidemiology; D008107:Liver Diseases / Q000150:complications*; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D012189:Retrospective Studies; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000473:pathology / Q000503:physiopathology; D013997:Time Factors
chemical_list: D054328:Proton Pump Inhibitors