title: Evaluation of potential circulating biomarkers for prediction of response to chemoradiation in patients with glioblastoma.
abstract: Surgery followed by chemoradiation and adjuvant chemotherapy is standard of care for patients with a glioblastoma (GBM). Due to its limited benefit, an upfront method to predict dismal outcome would prevent unnecessary toxic treatment. We searched for a predictive blood derived biomarker in a cohort of 55 patients with GBM. Increasing age (HR 1.03, 95 % CI 1.01-1.06), and postoperative tumor residue (HR 1.07, 95 % CI 1.02-1.15) were independently associated with unfavourable progression free survival (PFS) in these patients. Corticosteroid use before start of chemoradiaton was strongly predictive for outcome (HR 3.26, 95 % CI 1.67-6.39) with a mean PFS and OS in patients using corticosteroids of 7.3 and 14.6 months, versus 16.1 and 21.6 months in patients not using corticosteroids (p = 0.0005, p < 0.0067 respectively). Despite earlier reports, blood concentrations of YKL-40, Fetuin-a and haptoglobin were not predictive for response. In addition, serum peptide profiles, determined by MALDI-TOF mass spectroscopy, were not predictive as well. In conclusion, further biomarker discovery studies are needed to predict treatment outcome for patients with GBM in the near future.
authors.affiliation: Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Myra E
authors.initials: ME
authors.lastname: van Linde
authors.affiliation: Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Johannes C
authors.initials: JC
authors.lastname: van der Mijn
authors.affiliation: Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Thang V
authors.initials: TV
authors.lastname: Pham
authors.affiliation: Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Jaco C
authors.initials: JC
authors.lastname: Knol
authors.affiliation: Department of Neurosurgery, Neuro-oncology Research Group, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Laurine E
authors.initials: LE
authors.lastname: Wedekind
authors.affiliation: Department of Neurosurgery, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Koos E
authors.initials: KE
authors.lastname: Hovinga
authors.affiliation: Department of Radiology, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Esther Sanchez
authors.initials: ES
authors.lastname: Aliaga
authors.affiliation: Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Jan
authors.initials: J
authors.lastname: Buter
authors.affiliation: Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Connie R
authors.initials: CR
authors.lastname: Jimenez
authors.affiliation: Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Jaap C
authors.initials: JC
authors.lastname: Reijneveld
authors.affiliation: Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands. h.verheul@vumc.nl.
authors.forename: Henk M W
authors.initials: HM
authors.lastname: Verheul
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000097:blood; D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000473:pathology; D001932:Brain Neoplasms / Q000097:blood* / Q000628:therapy*; D059248:Chemoradiotherapy / Q000379:methods*; D000071451:Chitinase-3-Like Protein 1 / Q000097:blood; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D005909:Glioblastoma / Q000097:blood* / Q000628:therapy*; D006242:Haptoglobins / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D040901:Proteomics; D016896:Treatment Outcome; D055815:Young Adult; D060749:alpha-2-HS-Glycoprotein / Q000378:metabolism*
chemical_list: D000305:Adrenal Cortex Hormones; C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1; D006242:Haptoglobins; D060749:alpha-2-HS-Glycoprotein
keywords: Biomarker; First-line treatment; Glioblastoma multiforme; Proteomics