title: The Role of Spongia sp. in the Discovery of Marine Lead Compounds.
abstract: A comprehensive review on the chemistry of Spongia sp. is here presented, together with the biological activity of the isolated compounds. The compounds are grouped in sesquiterpene quinones, diterpenes, C21 and other linear furanoterpenes, sesterterpenes, sterols (including secosterols), macrolides and miscellaneous compounds. Among other reports we include studies on the intraspecific diversity of a Mediterranean species, compounds isolated from associated sponge and nudibranch and compounds isolated from S. zimocca and the red seaweed Laurentia microcladia. Under biological activity a table of the reported biological activities of the various compounds and the biological screening of extracts are described. The present review covers the literature from 1971 to 2015.
authors.affiliation: LAQV-REQUIMTE, Departamento de Qu&#237;mica, Faculdade de Ci&#234;ncias e Tecnologia, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal. psm@fct.unl.pt.
authors.forename: Patrícia
authors.initials: P
authors.lastname: Máximo
authors.affiliation: LAQV-REQUIMTE, Departamento de Qu&#237;mica, Faculdade de Ci&#234;ncias e Tecnologia, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal. lpf@fct.unl.pt.
authors.forename: Luísa M
authors.initials: LM
authors.lastname: Ferreira
authors.affiliation: LAQV-REQUIMTE, Departamento de Qu&#237;mica, Faculdade de Ci&#234;ncias e Tecnologia, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal. paula.branco@fct.unl.pt.
authors.forename: Paula
authors.initials: P
authors.lastname: Branco
authors.affiliation: Sea4Us-Biotecnologia de Recursos Marinhos, Ltd., 8650-378 Sagres, Portugal. pedro.lima@sea4us.pt.|Nova Medical School/Faculdade de Ci&#234;ncias M&#233;dicas, Universidade Nova de Lisboa, Campo M&#225;rtires da P&#225;tria 130, 1169-056 Lisboa, Portugal. pedro.lima@sea4us.pt.
authors.forename: Pedro
authors.initials: P
authors.lastname: Lima
authors.affiliation: LAQV-REQUIMTE, Departamento de Qu&#237;mica, Faculdade de Ci&#234;ncias e Tecnologia, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal. ana.lourenco@fct.unl.pt.
authors.forename: Ana
authors.initials: A
authors.lastname: Lourenço
mesh_terms: D000818:Animals; D001688:Biological Products / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology*; D005663:Furans / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology; D049851:Gastropoda / Q000737:chemistry*; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D011809:Quinones / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology; D012624:Seaweed / Q000737:chemistry*; D013261:Sterols / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology; D013729:Terpenes / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D001688:Biological Products; D005663:Furans; D018942:Macrolides; D010936:Plant Extracts; D011809:Quinones; D013261:Sterols; D013729:Terpenes
keywords: C21 furanoterpenes; Spongia sp.; biological activity; diterpenes; macrolides; sesquiterpene quinones; sesterterpenes; sterols