title: Lutein and Zeaxanthin Isomers in Eye Health and Disease.
abstract: Current evidence suggests lutein and its isomers play important roles in ocular development in utero and throughout the life span, in vision performance in young and later adulthood, and in lowering risk for the development of common age-related eye diseases in older age. These xanthophyll (oxygen-containing) carotenoids are found in a wide variety of vegetables and fruits, and they are present in especially high concentrations in leafy green vegetables. Additionally, egg yolks and human milk appear to be bioavailable sources. The prevalence of lutein, zeaxanthin, and meso-zeaxanthin in supplements is increasing. Setting optimal and safe ranges of intake requires additional research, particularly in pregnant and lactating women. Accumulating evidence about variable interindividual response to dietary intake of these carotenoids, based on genetic or metabolic influences, suggests that there may be subgroups that benefit from higher levels of intake and/or alternate strategies to improve lutein and zeaxanthin status.
authors.affiliation: Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53726-2336; email: Jmarespe@wisc.edu.
authors.forename: Julie
authors.initials: J
authors.lastname: Mares
mesh_terms: D000367:Age Factors; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use; D000975:Antioxidants / Q000009:adverse effects / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use; D000072001:Diet, Healthy; D019587:Dietary Supplements; D005128:Eye Diseases / Q000276:immunology / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D006801:Humans; D014975:Lutein / Q000009:adverse effects / Q000031:analogs & derivatives / Q000378:metabolism / Q000627:therapeutic use*; D008954:Models, Biological; D009928:Organ Specificity; D018384:Oxidative Stress; D012160:Retina / Q000254:growth & development / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D013237:Stereoisomerism; D014786:Vision Disorders / Q000276:immunology / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D065146:Zeaxanthins / Q000009:adverse effects / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D065146:Zeaxanthins; D014975:Lutein
keywords: carotenoids; cataract; macula; macular degeneration; retinopathy; vision