title: Oxidized LDL: As a risk factor for cardiovascular disease in renal transplantation.
abstract: OBJECTIVE
  The mortality rate of chronic kidney disease (CKD) patients that have undergone renal replacement therapy is very high due to cardiovascular diseases (CVD). Some studies have indicated that cyclosporine A, a drug used to prevent transplant rejection, is associated with bone loss following transplantation. Furthermore, it has an oxidative effect on circulating lipids. Its prooxidant effect on cell membranes causes calcium release. This study aimed to examine whether or not renal transplantation result in improvement in oxidative stress and to assess the association between oxidized LDL (ox-LDL) and some variables in the prediction of CVD risk in Renal Transplantation (RT) patients that were compared with the control group.
  
  
  METHODS
  A total number of 30 CKD patients were recruited to evaluate time dependent changes in biomarker of OS before and after RT. The ox-LDL, lipid metabolism parameters, CsA, creatinine, calcium and phosphate were assessed both before RT, 10 days and 6 months after RT in comparison with the control group (n = 30).
  
  
  RESULTS
  Over 6 months, ox-LDL concentration changed from 79.7 ± 9.7 to 72 ± 7 mU/mL (p < 0.009). calcium phosphate level was positively correlated with the concentration of ox-LDL (R = 0.467, p = 0.011) and cyclosporine (R = 0.419, p = 0.024) 6 months after transplantation.
  
  
  CONCLUSIONS
  The findings indicated that restoring renal function by transplantation, improves uremia induced oxidative stress. calcium phosphate product, as an independent risk factor for CVD, correlates with ox-LDL before RT and 6 months after RT. Calcium phosphate product correlates with cyclosporine in the RT group, too.
authors.affiliation: University of Medical Science, Iran.
authors.forename: Adele
authors.initials: A
authors.lastname: Soltani
authors.affiliation: University of Medical Science, Iran.
authors.forename: Hassan
authors.initials: H
authors.lastname: Argani
authors.affiliation: University of Medical Science, Iran.
authors.forename: Hooman
authors.initials: H
authors.lastname: Rahimipour
authors.affiliation: University of Medical Science, Iran.
authors.forename: Fateme
authors.initials: F
authors.lastname: Soleimani
authors.affiliation: University of Medical Science, Iran.
authors.forename: Foroug
authors.initials: F
authors.lastname: Rahimi
authors.affiliation: University of Medical Science, Iran.
authors.forename: Faranak
authors.initials: F
authors.lastname: Kazerouni
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000097:blood* / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D011183:Postoperative Complications / Q000097:blood* / Q000453:epidemiology*; D012307:Risk Factors
chemical_list: D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein