title: Science to Practice: Systemic Implications of Ablative Tumor Therapies-Reality Uncovered and Myths Exposed?
abstract: In their effort to characterize the systemic "off-target" effects of radiofrequency (RF) ablation and irreversible electroporation (IRE), Bulvik et al demonstrated substantial differences in physiologic, tumorigenic, and immunologic responses between the two ablative modalities. By establishing that IRE may in fact stimulate more robust inflammatory and systemic reactions than RF at liver ablation, the authors conclude that the selection of a given ablation energy source may alter the clinical outcome depending on the circumstance-both favorably and unfavorably.
authors.affiliation: Department of Diagnostic and Interventional Radiology Charité Universitätsmedizin Berlin Berlin, Germany.|Department of Radiology and Biomedical Imaging Yale University School of Medicine 333 Cedar St New Haven, CT 06520.
authors.forename: Julius
authors.initials: J
authors.lastname: Chapiro
authors.affiliation: Department of Diagnostic and Interventional Radiology Charité Universitätsmedizin Berlin Berlin, Germany.|Department of Radiology and Biomedical Imaging Yale University School of Medicine 333 Cedar St New Haven, CT 06520.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Geschwind
mesh_terms: D055011:Ablation Techniques / Q000379:methods*; D000818:Animals; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000601:surgery*; D015642:Radiology, Interventional / Q000379:methods*