title: Encapsulated Conjugated Oligomer Nanoparticles for Real-Time Photoacoustic Sentinel Lymph Node Imaging and Targeted Photothermal Therapy.
abstract: Noninvasive and nonionizing imaging of sentinel lymph nodes (SLN) is highly desirable for the detection of breast cancer metastasis through sentinel lymph node biopsy. Photoacoustic (PA) imaging is an emerging imaging technique that can serve as a suitable approach for SLN imaging. Herein, novel conjugated oligomer based nanoparticles (NPs) with strong NIR absorption, good biocompatibility, excellent PA contrast, and good photothermal conversion efficiency are reported. Real-time PA imaging of SLN reveals high resolution of the NPs via injection from the left forepaw pad. In addition, the surface functionalized NPs can target breast cancer cells and kill them efficiently and specifically through photothermal therapy upon 808 nm laser irradiation. This work shows great potential of the nanoparticle PA contrast agent to serve as a multifunctional probe for photothermal therapy at SLNs to achieve the inhibition of cancer cell metastasis in the near future.
authors.affiliation: Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore, 117585, Singapore.|NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, 28 Medical Drive, #05-01, Singapore, 117456, Singapore.
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Cai
authors.affiliation: Department of Chemistry and Biochemistry, Center for Polymers and Organic Solids, University of California, Santa Barbara, CA, 93107, USA.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Liu
authors.affiliation: Singapore Institute for Neurotechnology (SINAPSE), National University of Singapore, 28 Medical Drive, #05-COR, Singapore, 117456, Singapore.|Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County, 35053, Taiwan.
authors.forename: Lun-De
authors.initials: LD
authors.lastname: Liao
authors.affiliation: Singapore Institute for Neurotechnology (SINAPSE), National University of Singapore, 28 Medical Drive, #05-COR, Singapore, 117456, Singapore.|Department of Biomedical Engineering, National University of Singapore, 21 Lower Kent Ridge Road, Singapore, 119077, Singapore.
authors.forename: Aishwarya
authors.initials: A
authors.lastname: Bandla
authors.affiliation: Singapore Institute for Neurotechnology (SINAPSE), National University of Singapore, 28 Medical Drive, #05-COR, Singapore, 117456, Singapore.|National Neuroscience Institute (NNI), 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore.
authors.forename: Ji Min
authors.initials: JM
authors.lastname: Ling
authors.affiliation: Singapore Institute for Neurotechnology (SINAPSE), National University of Singapore, 28 Medical Drive, #05-COR, Singapore, 117456, Singapore.|Department of Electrical and Computer Engineering, National University of Singapore, 21 Lower Kent Ridge Road, Singapore, 119077, Singapore.
authors.forename: Yu-Hang
authors.initials: YH
authors.lastname: Liu
authors.affiliation: Singapore Institute for Neurotechnology (SINAPSE), National University of Singapore, 28 Medical Drive, #05-COR, Singapore, 117456, Singapore.|Department of Biomedical Engineering, National University of Singapore, 21 Lower Kent Ridge Road, Singapore, 119077, Singapore.|Department of Electrical and Computer Engineering, National University of Singapore, 21 Lower Kent Ridge Road, Singapore, 119077, Singapore.
authors.forename: Nitish
authors.initials: N
authors.lastname: Thakor
authors.affiliation: Department of Chemistry and Biochemistry, Center for Polymers and Organic Solids, University of California, Santa Barbara, CA, 93107, USA. bazan@chem.ucsb.edu.
authors.forename: Guillermo C
authors.initials: GC
authors.lastname: Bazan
authors.affiliation: Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore, 117585, Singapore. cheliub@nus.edu.sg.
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival; D006979:Hyperthermia, Induced; D021621:Imaging, Three-Dimensional; D008297:Male; D051379:Mice; D041681:NIH 3T3 Cells; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D061088:Photoacoustic Techniques / Q000379:methods*; D010789:Phototherapy; D017208:Rats, Wistar; D000071036:Sentinel Lymph Node / Q000473:pathology*; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature
keywords: conjugated oligomer; organic nanoparticles; photoacoustic imaging; photothermal therapy; sentinel lymph node