title: Origin and fate of the regenerating cells of the kidney.
abstract: The kidney has the capacity to regenerate itself provided that the damage is limited and the structure of the kidney remains intact. Nevertheless, in disease conditions this potential may be compromised, leading to progression to chronic kidney disease. For development of new therapeutic strategies it is a prerequisite to understand the origin and regulation of the kidney regenerating cells and the processes that underlie maladaptive repair. Because of the complexity of the kidney consisting of a high number of different cell types, it is a complex task to unravel the origin and fate of cells responsible for regeneration. This review summarises the recent and most important advances in identifying regenerating cell populations of the kidney, and highlights the existing controversies.
authors.affiliation: Department of Pathology, RIMLS, RIHS, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Eymael
authors.affiliation: Department of Pathology, RIMLS, RIHS, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: Bart.Smeets@radboudumc.nl.
authors.forename: Bart
authors.initials: B
authors.lastname: Smeets
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D019070:Cell Lineage; D006801:Humans; D007668:Kidney / Q000166:cytology* / Q000502:physiology*; D012038:Regeneration
keywords: Cell lineage tracing; Cells of renin lineage; Kidney regeneration; Parietal epithelial cell; Renal progenitor cell; Scattered tubular cells