title: Tuning photothermal properties of gold nanodendrites for in vivo cancer therapy within a wide near infrared range by simply controlling their degree of branching.
abstract: Although dendritic nanoparticles have been prepared by many different methods, control over their degree of branching (DB) is still impossible, preventing us from understanding the effect of the DB on the properties of the nanodendrites as cancer therapeutics. Herein, we developed a novel seed-mediated method to prepare gold nanodendrites (AuNDs) in an organic solvent using long chain amines as a structural directing agent. We discovered that the DB could be tuned facilely by simply adjusting synthetic parameters, such as the solvent type, the type and concentration of the long chain amines. We found that DB tuning resulted in dramatic tunability in the optical properties in the near infrared (NIR) range, which led to significantly different performance in the photothermal cancer therapy. Our in vitro and in vivo studies revealed that AuNDs with a higher DB were more efficient in photothermal tumor destruction under a lower wavelength NIR irradiation. In contrast, those with a lower DB performed better in tumor destruction under a higher wavelength NIR irradiation, indicating that AuNDs of even lower DB should have even better photothermal cancer therapy efficiency within the second NIR window. Thus, the tunable optical properties of AuNDs in the NIR range allow us to selectively determine a suitable laser wavelength for the best cancer therapeutic performance.
authors.affiliation: Department of Chemistry & Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, 101 Stephenson Parkway, Norman, OK, 73019, USA.
authors.forename: Penghe
authors.initials: P
authors.lastname: Qiu
authors.affiliation: Institute of Applied Bioresource Research, College of Animal Science, Zhejiang University, Yuhangtang Road 866, Hangzhou, Zhejiang, 310058, China. Electronic address: yangm@zju.edu.cn.
authors.forename: Mingying
authors.initials: M
authors.lastname: Yang
authors.affiliation: Department of Chemistry & Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, 101 Stephenson Parkway, Norman, OK, 73019, USA.
authors.forename: Xuewei
authors.initials: X
authors.lastname: Qu
authors.affiliation: Department of Chemistry & Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, 101 Stephenson Parkway, Norman, OK, 73019, USA.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Huai
authors.affiliation: Department of Chemistry & Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, 101 Stephenson Parkway, Norman, OK, 73019, USA.
authors.forename: Ye
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Chemistry & Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, 101 Stephenson Parkway, Norman, OK, 73019, USA; School of Materials Science and Engineering, Zhejiang University, Hangzhou, Zhejiang, 310027, China. Electronic address: cbmao@ou.edu.
authors.forename: Chuanbin
authors.initials: C
authors.lastname: Mao
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000528:radiation effects; D050091:Dendrimers / Q000737:chemistry / Q000627:therapeutic use; D005260:Female; D006046:Gold / Q000627:therapeutic use*; D006801:Humans; D007259:Infrared Rays / Q000627:therapeutic use; D061986:MCF-7 Cells; D053768:Metal Nanoparticles / Q000737:chemistry / Q000627:therapeutic use* / Q000648:ultrastructure*; D051379:Mice; D008819:Mice, Nude; D009374:Neoplasms, Experimental / Q000473:pathology / Q000628:therapy*; D010316:Particle Size; D010789:Phototherapy / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D050091:Dendrimers; D006046:Gold
keywords: Cancer therapy; Degree of branching; Gold; Nanodendrites