title: The influence of aripiprazole and olanzapine on neurotransmitters level in frontal cortex of prenatally stressed rats.
abstract: OBJECTIVE
  The study aims to verify whether alterations in the level of neurotransmitters have occurred in prenatally stressed rats (animal model of schizophrenia), and whether aripiprazole (ARI) and olanzapine (OLA) modify this level.
  
  
  METHODS
  The effects of ARI (1.5mg/kg) and OLA (0.5mg/kg) were studied by means of microdialysis in freely moving rats (observation time 120min). The level of neurotransmitters (DA, 5-HT, NA) and their metabolites (DOPAC, HVA, 5-HIAA) was analyzed by HPLC with coulochemical detection.
  
  
  RESULTS
  Obtained results indicate that after a single administration of ARI and OLA in the prenatally stressed rats the increase of DA, DOPAC, and 5-HT was observed. In turn ARI administration increase the level of HVA and 5-HIAA and also decrease the level of NA. After OLA administration the level of NA and HVA increased and no significant change in 5-HIAA was observed.
  
  
  CONCLUSIONS
  Alterations observed as a result of ARI and OLA administration may be pivotal in identifying animal models of mental disorders and in the analysis of neuroleptics effectiveness.
authors.affiliation: Department of Pharmacoeconomics and Social Pharmacy, Poznan University of Medical Sciences, Dabrowskiego 79, 60-529 Poznan, Poland.
authors.forename: P
authors.initials: P
authors.lastname: Ratajczak
authors.affiliation: Department of Pharmacoeconomics and Social Pharmacy, Poznan University of Medical Sciences, Dabrowskiego 79, 60-529 Poznan, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Kus
authors.affiliation: Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31-343 Cracow, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Gołembiowska
authors.affiliation: Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31-343 Cracow, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Noworyta-Sokołowska
authors.affiliation: Department of Toxicology, Poznan University of Medical Sciences, Dojazd 30, 60-631 Poznan, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Woźniak
authors.affiliation: Department of Pharmacoeconomics and Social Pharmacy, Poznan University of Medical Sciences, Dabrowskiego 79, 60-529 Poznan, Poland.
authors.forename: T
authors.initials: T
authors.lastname: Zaprutko
authors.affiliation: Department of Pharmacoeconomics and Social Pharmacy, Poznan University of Medical Sciences, Dabrowskiego 79, 60-529 Poznan, Poland. Electronic address: elapharm@ump.edu.pl.
authors.forename: E
authors.initials: E
authors.lastname: Nowakowska
mesh_terms: D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology; D000068180:Aripiprazole / Q000494:pharmacology*; D001569:Benzodiazepines / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism; D005260:Female; D005625:Frontal Lobe / Q000187:drug effects* / Q000378:metabolism*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism; D000077152:Olanzapine; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism; D013312:Stress, Physiological; D013315:Stress, Psychological
chemical_list: D014150:Antipsychotic Agents; D018377:Neurotransmitter Agents; D015102:3,4-Dihydroxyphenylacetic Acid; D001569:Benzodiazepines; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D000068180:Aripiprazole; D000077152:Olanzapine; D004298:Dopamine; D009638:Norepinephrine
keywords: Animal model of schizophrenia; Aripirazole; Microdialysis; Neurotransmitters; Olanzapine; Prenatal stress