title: Synthesis and Spectral Characterization of Benzo-[6,7][1,5]diazocino[2,1-a]isoindol-12-(14H)-one Derivatives.
abstract: A simple synthetic route affording 27%-85% yields of benzo[6,7][1,5]diazocino[2,1-a]isoindol-12(14H)-one ring systems from readily available 3-(2-oxo-2-phenylethyl) isobenzofuran-1(3H)-ones and 2-(aminomethyl)aniline starting materials in toluene and catalysed by p-toluene-sulfonic acid is developed. The ¹H- and (13)C-NMR spectra of the final products were assigned using a variety of one and two-dimensional NMR experiments. The distinction between the two potential isomers of the final products was made on the basis of heteronuclear multiple bond connectivity (HMBC) NMR spectra.
authors.affiliation: School of Life and Medical Sciences, University of Hertfordshire, Hatfield AL10 9AB, UK. j.p.bassin@herts.ac.uk.
authors.forename: Jatinder P
authors.initials: JP
authors.lastname: Bassin
authors.affiliation: School of Life and Medical Sciences, University of Hertfordshire, Hatfield AL10 9AB, UK. bhavani.anagani@gmail.com.
authors.forename: Bhavani
authors.initials: B
authors.lastname: Anagani
authors.affiliation: School of Life and Medical Sciences, University of Hertfordshire, Hatfield AL10 9AB, UK. c.d.benham@herts.ac.uk.
authors.forename: Christopher
authors.initials: C
authors.lastname: Benham
authors.affiliation: School of Life and Medical Sciences, University of Hertfordshire, Hatfield AL10 9AB, UK. m.goyal@herts.ac.uk.
authors.forename: Madhu
authors.initials: M
authors.lastname: Goyal
authors.affiliation: School of Life and Medical Sciences, University of Hertfordshire, Hatfield AL10 9AB, UK. u.gerhard@herts.ac.uk.
authors.forename: Maryam
authors.initials: M
authors.lastname: Hashemian
authors.affiliation: School of Life and Medical Sciences, University of Hertfordshire, Hatfield AL10 9AB, UK. u.gerhard@herts.ac.uk.
authors.forename: Ute
authors.initials: U
authors.lastname: Gerhard
mesh_terms: D054833:Isoindoles / Q000138:chemical synthesis* / Q000737:chemistry; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
chemical_list: D054833:Isoindoles
keywords: 2D-NMR; diazocine; isobenzofuran-1(3H)-ones; isoindole