title: Two-Step Screening of the Modified Checklist for Autism in Toddlers in Thai Children with Language Delay and Typically Developing Children.
abstract: This study aimed to validate the use of two-step Modified Checklist for Autism in Toddlers (M-CHAT) screening adapted for a Thai population. Our participants included both high-risk children with language delay (N = 109) and low-risk children with typical development (N = 732). Compared with the critical scoring criteria, the total scoring method (failing ≥3 items) yielded the highest sensitivity of 90.7 %; specificity was 99.7 %, positive predictive value 96.1 %, and negative predictive value 99.4 %. The two-step M-CHAT screening is a promising instrument that can be utilized to detect ASD in Thai children in both primary and clinical settings. Moreover, socio-cultural context should be considered when adopting the use and interpretation of the M-CHAT for each country.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.|King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Rama IV. Road, Bangkok, Thailand.
authors.forename: Pornchada
authors.initials: P
authors.lastname: Srisinghasongkram
authors.affiliation: King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Rama IV. Road, Bangkok, Thailand.|Division of Growth and Development, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Sor Kor Building 11th Floor, Bangkok, 10330, Thailand.
authors.forename: Chandhita
authors.initials: C
authors.lastname: Pruksananonda
authors.affiliation: King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Rama IV. Road, Bangkok, Thailand. weerasak.ch@chula.ac.th.|Division of Growth and Development, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Sor Kor Building 11th Floor, Bangkok, 10330, Thailand. weerasak.ch@chula.ac.th.
authors.forename: Weerasak
authors.initials: W
authors.lastname: Chonchaiya
mesh_terms: D001321:Autistic Disorder / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D057189:Checklist / Q000379:methods*; D002657:Child Development / Q000502:physiology; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007805:Language Development Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D008297:Male; D008403:Mass Screening / Q000379:methods*; D010290:Parents / Q000523:psychology; D012307:Risk Factors; D013785:Thailand / Q000453:epidemiology
keywords: Autism; Delayed language; M-CHAT; Screening; Speech