title: Combined salivary duct carcinoma and squamous cell carcinoma suspected of carcinoma ex pleomorphic adenoma.
abstract: A 76-year-old Japanese woman had noticed an asymptomatic and palpable mass in her left parotid gland region for 20 years. The tumor had showed rapid growth during the last two months. Therefore, the tumor was clinically suspected of being a malignant tumor and was surgically resected. A histopathological examination revealed that the tumor consisted of two different histopathological neoplastic components accompanied by hyalinized fibrosis at the center of the tumor. The two-neoplastic components were squamous cell carcinoma and salivary duct carcinoma. The tumor was suspected to be a carcinoma ex pleomorphic adenoma after considering the clinical course and the histopathological findings, such as hyalinized fibrosis at the center of the tumor. There was no evidence of recurrence at 30 months after the surgical resection.
authors.affiliation: Division of Pathology, Exploratory Oncology Research & Clinical Trial Center National Cancer Center, Kashiwa, Chiba, 277-8577, Japan.|Department of Head and Neck Medical Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, 277-8577, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Enokida
authors.affiliation: Division of Pathology, Exploratory Oncology Research & Clinical Trial Center National Cancer Center, Kashiwa, Chiba, 277-8577, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Fujii
authors.affiliation: Diagnostic Radiology Division, National Cancer Center Hospital East, Kashiwa, Chiba, 277-8577, Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Kuno
authors.affiliation: Head and Neck Surgery Division, National Cancer Center Hospital East, Kashiwa, Chiba, 277-8577, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Mukaigawa
authors.affiliation: Department of Head and Neck Medical Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, 277-8577, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Tahara
authors.affiliation: Plastic and Reconstructive Surgery Division, National Cancer Center Hospital East, Kashiwa, Chiba, 277-8577, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Sakuraba
authors.affiliation: Head and Neck Surgery Division, National Cancer Center Hospital East, Kashiwa, Chiba, 277-8577, Japan.
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Hayashi
mesh_terms: D008949:Adenoma, Pleomorphic / Q000473:pathology*; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D044584:Carcinoma, Ductal / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D010307:Parotid Neoplasms / Q000473:pathology*; D000077195:Squamous Cell Carcinoma of Head and Neck
chemical_list: D014408:Biomarkers, Tumor
keywords: carcinoma ex pleomorphic adenoma; mixed salivary gland tumor; salivary duct carcinoma; salivary gland neoplasm; squamous cell carcinoma