title: Group 5 Pulmonary Hypertension: The Orphan's Orphan Disease.
abstract: Pulmonary hypertension is a complex disorder with multiple etiologies; the World Health Organization classification system divides pulmonary hypertension patients into 5 groups based on the underlying cause and mechanism. Group 5 pulmonary hypertension is a heterogeneous group of diseases that encompasses pulmonary hypertension secondary to multifactorial mechanisms. For many of the diseases, the true incidence, etiology, and treatment remain uncertain. This article reviews the epidemiology, pathogenesis, and management of many of the group 5 pulmonary hypertension disease states.
authors.affiliation: Section of Cardiology, Department of Medicine, University of Chicago Medical Center, 5841 South Maryland Avenue, MC 5403, Chicago, IL 60637, USA.
authors.forename: Sara
authors.initials: S
authors.lastname: Kalantari
authors.affiliation: Section of Cardiology, Department of Medicine, University of Chicago Medical Center, 5841 South Maryland Avenue, MC 5403, Chicago, IL 60637, USA; Pulmonary Hypertension Program, Cardiovascular Division, University of Chicago Medical Center, 5841 South Maryland Avenue, MC 5403, Chicago, IL 60637, USA. Electronic address: mgomberg@bsd.uchicago.edu.
authors.forename: Mardi
authors.initials: M
authors.lastname: Gomberg-Maitland
mesh_terms: D014943:Global Health; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D015994:Incidence; D015995:Prevalence; D011669:Pulmonary Wedge Pressure / Q000502:physiology*; D035583:Rare Diseases
keywords: Chronic thromboembolic pulmonary hypertension; Multifactorial; Pulmonary hypertension