title: The protective effect of a buckwheat-enriched diet on renal injury in high salt-induced hypertension in rats.
abstract: An excess of dietary salt is the most common factor that contributes to the pathogenesis of hypertension. Dietary management is deemed critical to prevent and treat hypertension. We aimed at evaluating the preventive effect of the buckwheat (BW)-enriched diet on high salt-induced elevation of blood pressure (BP) and renal injury in order to provide a new focus on the design of strategies to prevent hypertension. Control, high salt (HS)-treated (8%), HS + tartary buckwheat (TB) (8% HS + 15% TB), and a group of HS + common buckwheat (CB) (8% HS + 15% CB) rats were used for 7 weeks. BP was monitored periodically during the study by the tail cuff method. HS intake caused a significant increase of BP, the level of serum Na(+) compared to the control group. BW significantly prevented the increase of BP, attenuated oxidative damage, and improved Na(+)/K(+)-ATPase activity in HS treated rats. These results show that a diet supplemented with whole BW has beneficial effects on hypertension, by decreasing blood pressure values and oxidative stress.
authors.affiliation: Key Laboratory of Food Safety and Sanitation, Ministry of Education, College of Food Engineering and Biotechnology, Tianjin University of Science and Technology, Tianjin, People's Republic of China. wangchunling@tust.edu.cn.
authors.forename: Dai
authors.initials: D
authors.lastname: Cheng
authors.forename: Xinyu
authors.initials: X
authors.lastname: Zhang
authors.forename: Meng
authors.initials: M
authors.lastname: Meng
authors.forename: Lirong
authors.initials: L
authors.lastname: Han
authors.forename: Zheng
authors.initials: Z
authors.lastname: Li
authors.forename: Lihua
authors.initials: L
authors.lastname: Hou
authors.forename: Wentao
authors.initials: W
authors.lastname: Qi
authors.forename: Chunling
authors.initials: C
authors.lastname: Wang
mesh_terms: D000251:Adenosine Triphosphatases / Q000235:genetics / Q000378:metabolism; D000818:Animals; D001794:Blood Pressure; D004032:Diet; D004195:Disease Models, Animal; D019612:Fagopyrum / Q000737:chemistry*; D005527:Food, Fortified; D006973:Hypertension / Q000139:chemically induced / Q000178:diet therapy*; D007668:Kidney / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism; D009569:Nitric Oxide / Q000097:blood; D018384:Oxidative Stress; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D017673:Sodium Chloride, Dietary / Q000009:adverse effects*; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D016328:NF-kappa B; D012333:RNA, Messenger; D017673:Sodium Chloride, Dietary; D009569:Nitric Oxide; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D000251:Adenosine Triphosphatases