title: Measuring indirect effects of rotavirus vaccine in low income countries.
abstract: Widespread introduction of rotavirus vaccines has led to major reductions in the burden of rotavirus gastroenteritis worldwide. Vaccine effectiveness is diminished, however, in low income countries, that harbour the greatest burden of rotavirus attributed morbidity and mortality. Indirect effects of rotavirus vaccine (herd immunity and herd protection) could increase population level impact and improve vaccine cost effectiveness in such settings. While rotavirus vaccine indirect effects have been demonstrated in high and middle income countries, there are very little data from low income countries where force of infection, population structures and vaccine schedules differ. Targeted efforts to evaluate indirect effects of rotavirus vaccine in low income countries are required to understand the total impact of rotavirus vaccine on the global burden of rotavirus disease.
authors.affiliation: Malawi-Liverpool-Wellcome Trust Clinical Research Programme, P.O Box 30960, Chichiri, Blantyre 3, Malawi; Institute of Infection & Global Health, University of Liverpool, 8 West Derby Street, Liverpool L69 7BE, UK.
authors.forename: Aisleen
authors.initials: A
authors.lastname: Bennett
authors.affiliation: Malawi-Liverpool-Wellcome Trust Clinical Research Programme, P.O Box 30960, Chichiri, Blantyre 3, Malawi; Institute of Infection & Global Health, University of Liverpool, 8 West Derby Street, Liverpool L69 7BE, UK.
authors.forename: Naor
authors.initials: N
authors.lastname: Bar-Zeev
authors.affiliation: Malawi-Liverpool-Wellcome Trust Clinical Research Programme, P.O Box 30960, Chichiri, Blantyre 3, Malawi; Institute of Infection & Global Health, University of Liverpool, 8 West Derby Street, Liverpool L69 7BE, UK. Electronic address: n.a.cunliffe@liv.ac.uk.
authors.forename: Nigel A
authors.initials: NA
authors.lastname: Cunliffe
mesh_terms: D017281:Cost of Illness; D003362:Cost-Benefit Analysis; D003906:Developing Countries; D005759:Gastroenteritis / Q000401:mortality / Q000517:prevention & control* / Q000821:virology; D006801:Humans; D032521:Immunity, Herd; D012400:Rotavirus Infections / Q000517:prevention & control*; D022243:Rotavirus Vaccines / Q000627:therapeutic use*
chemical_list: D022243:Rotavirus Vaccines
keywords: Gastroenteritis; Herd effects; Rotavirus; Vaccine