title: [Application of chromosomal microarray analysis for a cohort of Chinese patients with spontaneous miscarriage].
abstract: OBJECTIVE
  To explore the relationship between spontaneous miscarriage and chromosomal aberrations identifiable with chromosomal microarray analysis (CMA).
  
  
  METHODS
  A total of 440 product-of-conceptions were collected for the CMA testing.
  
  
  RESULTS
  Four hundred and seventeen of 440 specimens (94.7%) were successfully detected, among which 209 (50.1%) were chromosomal abnormalities. One hundred and twenty-nine (61.7%) of the 209 specimens were numerical chromosomal abnormalities, 40 specimens (19.1%) were structural anomalies, 38 specimens (18.1%) were mosaicisms, and 2 specimens (1.0%) showed regions of homozygosity.
  
  
  CONCLUSIONS
  CMA analysis of products of-conception specimens can yield a higher diagnostic rate than conventional karyotyping. The identification of the cause of spontaneous miscarriage can facilitate estimation of recurrence risks for future pregnancies.
authors.affiliation: Guangzhou Kingmed Center for Clinical Laboratory, Guangzhou, Guangdong 510330, China. Email: haimingyuan@sina.cn.
authors.forename: Haiming
authors.initials: H
authors.lastname: Yuan
authors.forename: Mengfan
authors.initials: M
authors.lastname: Chen
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Deng
authors.forename: Fen
authors.initials: F
authors.lastname: Lyu
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology / Q000235:genetics*; D002869:Chromosome Aberrations; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007621:Karyotyping; D046228:Microarray Analysis / Q000379:methods*; D011247:Pregnancy