title: [Preparation and biocompatibility of a novel strontium-containing calcium sulfate].
abstract: OBJECTIVE
  To prepare a novel strontium-containing calcium sulfate and assess its and biocompatibility.
  
  
  METHODS
  A novel strontium-containing α-calcium sulfate hemihydrate (Sr-caS) bone substitute as prepared with hydrothermal reaction and examined for X-ray diffraction (XRD), Fourier transform infrared (FTIR) and thermogravimetric differential scanning calorimetric (TG-DSC) patterns. The biocompatibility of the material was evaluated by in vitro cytotoxicity test in L-929 cells, hemolysis test of blood, and in vivo implantation test in SD rats.
  
  
  RESULTS
  The XRD spectra of the prepared Sr-CaS powder highlighted 3 strong characteristic peaks of α-CaSO4 at 14.63°, 25.72° and 29.80° with a strontium-specific peak at 24.78°. The FTIR patterns of Sr-CaS resembled those of CaS. TG-DSC results showed that the material contained a non-evaporable water content of 6.03%. In vitro cytotoxicity test in L-929 cells suggested that the material had a class 1 cytotoxicity, and the hemolysis rate of its aqueous extract was 4.3%. The material implanted in the muscular tissues of SD rats maintained a steady state in the surrounding tissues.
  
  
  CONCLUSIONS
  This strontium-containing calcium sulfate material we prepared shows an excellent biocompatibility for potential use as a novel artificial bone material.
authors.affiliation: Department of Orthopedic Trauma, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.E-mail: xiaoyihou@yeah.net.
authors.forename: Yi-Long
authors.initials: YL
authors.lastname: Hou
authors.forename: Xue
authors.initials: X
authors.lastname: Li
authors.forename: Chang-Peng
authors.initials: CP
authors.lastname: Xu
authors.forename: Jin-Qi
authors.initials: JQ
authors.lastname: Song
authors.forename: Lei
authors.initials: L
authors.lastname: Huang
authors.forename: Bin
authors.initials: B
authors.lastname: Yu
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D018786:Bone Substitutes / Q000737:chemistry*; D002133:Calcium Sulfate / Q000737:chemistry*; D002460:Cell Line; D051379:Mice; D008855:Microscopy, Electron, Scanning; D019736:Prostheses and Implants; D051381:Rats; D017207:Rats, Sprague-Dawley; D017550:Spectroscopy, Fourier Transform Infrared; D013324:Strontium / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D002133:Calcium Sulfate; D013324:Strontium