title: Impaired Memory in OT-II Transgenic Mice Is Associated with Decreased Adult Hippocampal Neurogenesis Possibly Induced by Alteration in Th2 Cytokine Levels.
abstract: Recently, an increasing number of studies have focused on the effects of CD4+ T cell on cognitive function. However, the changes of Th2 cytokines in restricted CD4+ T cell receptor (TCR) repertoire model and their effects on the adult hippocampal neurogenesis and memory are not fully understood. Here, we investigated whether and how the mice with restricted CD4+ repertoire TCR exhibit learning and memory impairment by using OT-II mice. OT-II mice showed decreased adult neurogenesis in hippocampus and short- and long- term memory impairment. Moreover, Th2 cytokines in OT-II mice are significantly increased in peripheral organs and IL-4 is significantly increased in brain. Finally, IL-4 treatment significantly inhibited the proliferation of cultured adult rat hippocampal neural stem cells. Taken together, abnormal level of Th2 cytokines can lead memory dysfunction via impaired adult neurogenesis in OT-II transgenic.
authors.affiliation: Department of Biochemistry, College of Medicine, Konyang University, Dajeon 35365, Korea.
authors.forename: Seong Gak
authors.initials: SG
authors.lastname: Jeon
authors.affiliation: Department of Biochemistry, College of Medicine, Konyang University, Dajeon 35365, Korea.
authors.forename: Kyoung Ah
authors.initials: KA
authors.lastname: Kim
authors.affiliation: Department of Core Research Laboratory, Clinical Research Institute, Kyung Hee University Hospital at Gangdong, Seoul 0527, Korea.
authors.forename: Hyunju
authors.initials: H
authors.lastname: Chung
authors.affiliation: Department of Core Research Laboratory, Clinical Research Institute, Kyung Hee University Hospital at Gangdong, Seoul 0527, Korea.
authors.forename: Junghyun
authors.initials: J
authors.lastname: Choi
authors.affiliation: Department of Biochemistry, College of Medicine, Konyang University, Dajeon 35365, Korea.
authors.forename: Eun Ji
authors.initials: EJ
authors.lastname: Song
authors.affiliation: Department of Anatomy, College of Medicine, Konyang University, Dajeon 35365, Korea.
authors.forename: Seung-Yun
authors.initials: SY
authors.lastname: Han
authors.affiliation: Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea.
authors.forename: Myung Sook
authors.initials: MS
authors.lastname: Oh
authors.affiliation: Laboratory Animal Medicine, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Korea.
authors.forename: Jong Hwan
authors.initials: JH
authors.lastname: Park
authors.affiliation: Department of Nursing, College of Nursing, Jeju National University, Jeju 63243, Korea.
authors.forename: Jin-Il
authors.initials: JI
authors.lastname: Kim
authors.affiliation: Department of Biochemistry, College of Medicine, Konyang University, Dajeon 35365, Korea.|Konyang University Myunggok Medical Research Institute, Dajeon 35365, Korea.
authors.forename: Minho
authors.initials: M
authors.lastname: Moon
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D002478:Cells, Cultured; D003071:Cognition / Q000502:physiology; D006624:Hippocampus / Q000378:metabolism* / Q000473:pathology; D015847:Interleukin-4 / Q000378:metabolism*; D008297:Male; D008569:Memory Disorders / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D058953:Neural Stem Cells / Q000502:physiology*; D055495:Neurogenesis / Q000235:genetics / Q000276:immunology; D015213:Neuroimmunomodulation; D051381:Rats; D011919:Rats, Inbred Strains; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D018418:Th2 Cells / Q000502:physiology*
chemical_list: D011948:Receptors, Antigen, T-Cell; D015847:Interleukin-4
keywords: CD4 T cells; OT-II transgenic mice; Th2 cytokines; adult neurogenesis; cognition