title: Injectable and responsively degradable hydrogel for personalized photothermal therapy.
abstract: Near infrared-absorbing hydrogels are used for the repeated photothermal treatments of cancer. However, a long-term retention of hydrogel in the body leads to increased risk of toxicity. Here we developed an injectable and on-demand degradable hydrogel to conduct the repeated photothermal therapies (PTTs). Alginate-calcium hydrogel immobilized dendrimer-encapsulated platinum nanoparticles (DEPts) in its matrix represented excellent biocompatibility, and was degraded upon injecting chelates. Results from the in vivo studies reveal that the hydrogel/DEPts-mediated repeated PTTs suppressed tumor growth efficiently, and the hydrogel was degraded on-demand to allow renal secretion of DEPts out of the body. Furthermore, coating hydrogel/DEPts on the tumor instead of intratumoral injection could still ablate tumor efficiently. Our investigation provides a smart and safe hydrogel for photothermal cancer therapy.
authors.affiliation: Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, 200241, PR China.
authors.forename: Changping
authors.initials: C
authors.lastname: Wang
authors.affiliation: Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, 200241, PR China.
authors.forename: Xinyu
authors.initials: X
authors.lastname: Wang
authors.affiliation: Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, 200241, PR China.
authors.forename: Kunyu
authors.initials: K
authors.lastname: Dong
authors.affiliation: Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, 200241, PR China.
authors.forename: Jian
authors.initials: J
authors.lastname: Luo
authors.affiliation: Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, 200241, PR China. Electronic address: qzhang@bio.ecnu.edu.cn.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, 200241, PR China. Electronic address: yycheng@mail.ustc.edu.cn.
authors.forename: Yiyun
authors.initials: Y
authors.lastname: Cheng
mesh_terms: D020341:Absorbable Implants; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000008:administration & dosage* / Q000737:chemistry*; D006979:Hyperthermia, Induced / Q000379:methods; D015552:Injections, Intralesional; D061986:MCF-7 Cells; D053768:Metal Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D009374:Neoplasms, Experimental / Q000473:pathology* / Q000628:therapy*; D010789:Phototherapy / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D020136:Hydrogel, Polyethylene Glycol Dimethacrylate
keywords: Cancer therapy; Non-invasive; On-demand degradation; Repeated photothermal therapy; Responsive hydrogel