title: Relationship between IDH1 mutation and preoperative seizure in low-grade gliomas: A meta-analysis.
abstract: OBJECTIVE
  The aim of this analysis was to perform a meta-analysis assessing the relationship between isocitrate dehydrogenase 1 (IDH1) mutation and preoperative seizure in low-grade gliomas.
  
  
  METHODS
  Systematic computerised searches of the PubMed and Web of Knowledge were performed. The meta-analysis of pooled odds ratio (OR) and 95% confidence interval (CI) for preoperative seizure risk stratified by IDH1 mutation status were calculated.
  
  
  RESULTS
  Five studies with 540 patients were included for meta-analysis. The preoperative seizure incidence ranged from 73.54% to 94.12% in the IDH1 Mutation (+) group, compared 37.50%-76.92% in the IDH1 Mutation (-) group. The pooled crude OR was 2.750 (95% CI 1.763-4.290; Z=4.46, P=0.000). The Begg's test (z=0.73, P=0.462), the Egger's test (t=0.41, P=0.708) and symmetrical funnel plot suggested no significant publication bias. Sensitivity analysis by only pooled adjusted ORs showed the pooled OR was 2.740 (95% CI 1.593-4.714; Z=3.64, P=0.000) which indicated the results were robust. Meta-regression analysis showed preoperative seizure OR was not related with preoperative seizure incidence (t=0.37, P=0.736), and not related with IDH1 mutation rate (t=1.85, P=0.162).
  
  
  CONCLUSIONS
  Our meta-analysis indicated that IDH1 mutation was related with preoperative seizure in low-grade gliomas.
authors.affiliation: Department of Neurosurgery, Nantong First People's Hospital, North Haierxiang Road 6#, Nantong City, Jiangsu Province, 226001, PR China. Electronic address: pphss@126.com.
authors.forename: Zhi-Feng
authors.initials: ZF
authors.lastname: Wang
authors.affiliation: Nantong University, Qixiu Road 19#, Nantong City, Jiangsu Province, PR China.
authors.forename: Hong-Lin
authors.initials: HL
authors.lastname: Chen
mesh_terms: D001932:Brain Neoplasms / Q000150:complications / Q000453:epidemiology / Q000235:genetics*; D005910:Glioma / Q000150:complications / Q000209:etiology / Q000235:genetics*; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000235:genetics*; D012640:Seizures / Q000150:complications / Q000209:etiology / Q000235:genetics*
chemical_list: D007521:Isocitrate Dehydrogenase; C543588:IDH1 protein, human
keywords: IDH1 mutation; Low-grade gliomas; Meta-analysis; Preoperative seizure