title: Metabolic Profiles of Obesity in American Indians: The Strong Heart Family Study.
abstract: Obesity is a typical metabolic disorder resulting from the imbalance between energy intake and expenditure. American Indians suffer disproportionately high rates of obesity and diabetes. The goal of this study is to identify metabolic profiles of obesity in 431 normoglycemic American Indians participating in the Strong Heart Family Study. Using an untargeted liquid chromatography-mass spectrometry, we detected 1,364 distinct m/z features matched to known compounds in the current metabolomics databases. We conducted multivariate analysis to identify metabolic profiles for obesity, adjusting for standard obesity indicators. After adjusting for covariates and multiple testing, five metabolites were associated with body mass index and seven were associated with waist circumference. Of them, three were associated with both. Majority of the obesity-related metabolites belongs to lipids, e.g., fatty amides, sphingolipids, prenol lipids, and steroid derivatives. Other identified metabolites are amino acids or peptides. Of the nine identified metabolites, five metabolites (oleoylethanolamide, mannosyl-diinositol-phosphorylceramide, pristanic acid, glutamate, and kynurenine) have been previously implicated in obesity or its related pathways. Future studies are warranted to replicate these findings in larger populations or other ethnic groups.
authors.affiliation: Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, United States of America.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, United States of America.
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Missouri Breaks Industries Research Inc, Timber Lake, SD, United States of America.
authors.forename: Lyle G
authors.initials: LG
authors.lastname: Best
authors.affiliation: MedStar Health Research Institute, Hyattsville, MD, United States of America.
authors.forename: Jason G
authors.initials: JG
authors.lastname: Umans
authors.affiliation: Division of Pulmonary Medicine, Emory University School of Medicine, Atlanta, GA, United States of America.
authors.forename: Karan
authors.initials: K
authors.lastname: Uppal
authors.affiliation: Division of Pulmonary Medicine, Emory University School of Medicine, Atlanta, GA, United States of America.
authors.forename: ViLinh T
authors.initials: VT
authors.lastname: Tran
authors.affiliation: Division of Pulmonary Medicine, Emory University School of Medicine, Atlanta, GA, United States of America.
authors.forename: Dean P
authors.initials: DP
authors.lastname: Jones
authors.affiliation: Center for American Indian Health Research, University of Oklahoma Health Science Center, Oklahoma City, OK, United States of America.
authors.forename: Elisa T
authors.initials: ET
authors.lastname: Lee
authors.affiliation: Medstar Research Institute and Georgetown and Howard Universities Centers for Translational Sciences, Washington, DC, United States of America.
authors.forename: Barbara V
authors.initials: BV
authors.lastname: Howard
authors.affiliation: Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, United States of America.
authors.forename: Jinying
authors.initials: J
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000328:Adult; D000596:Amino Acids / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002853:Chromatography, Liquid; D016208:Databases, Factual; D005215:Fasting; D005260:Female; D006801:Humans; D007198:Indians, North American; D007333:Insulin Resistance; D008297:Male; D013058:Mass Spectrometry; D055442:Metabolome; D055432:Metabolomics / Q000379:methods; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000175:diagnosis / Q000208:ethnology* / Q000503:physiopathology; D010455:Peptides / Q000097:blood; D011446:Prospective Studies; D012307:Risk Factors; D013107:Sphingolipids / Q000097:blood; D013256:Steroids / Q000097:blood; D014481:United States; D055105:Waist Circumference
chemical_list: D000596:Amino Acids; D001786:Blood Glucose; D010455:Peptides; D013107:Sphingolipids; D013256:Steroids