title: Menaquinone as a potential target of antibacterial agents.
abstract: The current trend of increasing infections by multidrug-resistant pathogens requires the discovery of novel antimicrobial agents with new target and selective toxicity towards pathogens. Menaquinone is a component of electron transport chains in a majority of anaerobic bacteria and Gram-positive bacteria. Due to its exclusivity in bacteria, menaquinone is thought to be a potential target for development of therapeutically effective antibacterial agents without side effects. In this review, we summarize inhibitors of menaquinone biosynthesis and antibiotics directly targeting menaquinone in bacteria.
authors.affiliation: Teikyo University Institute of Medical Mycology.
authors.forename: Atmika
authors.initials: A
authors.lastname: Paudel
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hamamoto
authors.forename: Suresh
authors.initials: S
authors.lastname: Panthee
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Sekimizu
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D024901:Drug Resistance, Multiple, Bacterial; D004579:Electron Transport / Q000187:drug effects; D024482:Vitamin K 2 / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D024482:Vitamin K 2