title: Incisal margin condition after LEEP for cervical intraepithelial neoplasia patients and prognosis.
abstract: The aim of the study was to examine the relationship between incisal condition after loop electrosurgical excision procedure (LEEP) operation for cervical intraepithelial neoplasia (CIN) patients and prognosis. A study of high-risk incisal margin positive cases was also performed. We compared the differences in the prognosis of the 1-year follow-up visit in the 120 CIN patients admitted to the hospital during the period from April 2013 to April 2014. A total of 43 cases of positive incisal margin (35.8%), and 77 negative cases were included in the study. The differences in age, course of disease, and CIN level between the two groups showed no statistical significance (P>0.05). In the positive group, the positive ratio was significantly higher than that of the negative group (P<0.05). The positive incisal margin showed a significant positive correlation with human papillomavirus (HPV) positivity (r=0.327, P=0.035). The condition of most patients with positive incisal margin and HPV was critical, which was followed by positive incisal margin and negative HPV. The patients with the best prognosis were those with significant negative incisal margin as well as HPV (P<0.05). In conclusion, the positive incisal margin after LEEP operation was associated with relapse of the disease. Thus, considering the HPV test into consideration is valuable for the prognosis of the disease.
authors.affiliation: Department of Gynaecology, Binzhou City Center Hospital, Binzhou, Shandong 251700, P.R. China.
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Science and Education, Binzhou City Center Hospital, Binzhou, Shandong 251700, P.R. China.
authors.forename: Xiufeang
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Gynaecology, Jining No. 1 People's Hospital, Jining, Shandong 272111, P.R. China.
authors.forename: Lina
authors.initials: L
authors.lastname: Xu
keywords: cervical intraepithelial neoplasia; human papillomavirus; incisal margin condition; loop electrosurgical excision procedure