title: Effects of citalopram on jaw-closing muscle activity during sleep and wakefulness in mice.
abstract: In this study, we investigated the effects of chronic administration of the selective serotonin reuptake inhibitor (SSRI) citalopram on sleep/wake cycles and masseter (jaw-closing) muscle electromyogram (EMG) activity over a 24-h period. From the dark to the light period, the times of wakefulness decreased, while those of non-rapid eye movement (NREM) and REM sleep increased. Citalopram did not induce major alterations in the temporal changes of sleep-wake distributions, except for leading to a decrease in the time of NREM sleep during the light period and an increase in the durations of REM sleep episodes. Moreover, citalopram did not modify mean masseter EMG activity during any of the vigilance states and did not affect the temporal changes related to the shifts between dark/light periods. However, citalopram increased the time engaged in masseter EMG activation during NREM sleep in the second and the first halves of the dark and light periods, respectively. These results suggest that chronic citalopram treatment does not affect the temporal changes of sleep-wake distributions, but has a limited facilitatory influence that fails to increase the number of epochs of high levels of masseter muscle activation.
authors.affiliation: Department of Oral Physiology, Showa University School of Dentistry, 1-5-8, Hatanodai, Shinagawa, Tokyo 142-8555, Japan; Removable Partial Prosthodontics, Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo, Tokyo 113-8549, Japan.
authors.forename: Yasuha
authors.initials: Y
authors.lastname: Ikawa
authors.affiliation: Department of Oral Physiology, Showa University School of Dentistry, 1-5-8, Hatanodai, Shinagawa, Tokyo 142-8555, Japan.
authors.forename: Ayako
authors.initials: A
authors.lastname: Mochizuki
authors.affiliation: Department of Prosthodontics, Showa University School of Dentistry, 2-1-1, Kitasenzoku, Ohta, Tokyo 145-8515, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Katayama
authors.affiliation: Department of Oral Anatomy and Neurobiology, Graduate School of Dentistry, Osaka University, 1-8, Yamadaoka, Suita, Osaka 565-0871, Japan.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Kato
authors.affiliation: Department of Prosthodontics, Showa University School of Dentistry, 2-1-1, Kitasenzoku, Ohta, Tokyo 145-8515, Japan.
authors.forename: Minako
authors.initials: M
authors.lastname: Ikeda
authors.affiliation: Department of Prosthodontics, Showa University School of Dentistry, 2-1-1, Kitasenzoku, Ohta, Tokyo 145-8515, Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Abe
authors.affiliation: Department of Oral Physiology, Showa University School of Dentistry, 1-5-8, Hatanodai, Shinagawa, Tokyo 142-8555, Japan.
authors.forename: Shiro
authors.initials: S
authors.lastname: Nakamura
authors.affiliation: Department of Oral Physiology, Showa University School of Dentistry, 1-5-8, Hatanodai, Shinagawa, Tokyo 142-8555, Japan.
authors.forename: Kiyomi
authors.initials: K
authors.lastname: Nakayama
authors.affiliation: Removable Partial Prosthodontics, Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo, Tokyo 113-8549, Japan.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Wakabayashi
authors.affiliation: Department of Prosthodontics, Showa University School of Dentistry, 2-1-1, Kitasenzoku, Ohta, Tokyo 145-8515, Japan.
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Baba
authors.affiliation: Department of Oral Physiology, Showa University School of Dentistry, 1-5-8, Hatanodai, Shinagawa, Tokyo 142-8555, Japan. Electronic address: inouet@dent.showa-u.ac.jp.
authors.forename: Tomio
authors.initials: T
authors.lastname: Inoue
mesh_terms: D000818:Animals; D015283:Citalopram / Q000494:pharmacology*; D004576:Electromyography; D007568:Jaw / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008406:Masseter Muscle / Q000187:drug effects* / Q000502:physiology; D008810:Mice, Inbred C57BL; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D012890:Sleep / Q000502:physiology*; D014851:Wakefulness / Q000502:physiology*
chemical_list: D015283:Citalopram; D017367:Selective Serotonin Reuptake Inhibitors
keywords: Citalopram; Electromyogram; Masseter muscle; Mouse; Non-REM sleep; REM sleep