title: Austalides S-U, New Meroterpenoids from the Sponge-Derived Fungus Aspergillus aureolatus HDN14-107.
abstract: Three new meroterpenoids, named austalides S-U (1-3), were isolated from the culture of a sponge-derived fungus Aspergillus aureolatus HDN14-107, together with eleven known austalides derivates (4-14). Their structures, including absolute configurations, were assigned on the basis of NMR, MS data, and TDDFT ECD calculations. Compound 1 is the first case of austalides with the terpene ring fused to the chroman ring in trans configuration. Compounds 3 and 5 exhibited activities against influenza virus A (H1N1), with IC50 values of 90 and 99 μM, respectively.
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China. pengjixing1987@163.com.
authors.forename: Jixing
authors.initials: J
authors.lastname: Peng
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China. xiaominzhang91@163.com.
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China. wwwakin@ouc.edu.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China. zhutj@ouc.edu.cn.
authors.forename: Tianjiao
authors.initials: T
authors.lastname: Zhu
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China. guqianq@ouc.edu.cn.
authors.forename: Qianqun
authors.initials: Q
authors.lastname: Gu
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China. dehaili@ouc.edu.cn.|Laboratory for Marin Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China. dehaili@ouc.edu.cn.
authors.forename: Dehai
authors.initials: D
authors.lastname: Li
mesh_terms: D000818:Animals; D001230:Aspergillus / Q000737:chemistry*; D005658:Fungi / Q000737:chemistry*; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D013729:Terpenes
keywords: austalide; fungus; influenza virus A