title: The oxidative stress in the liver of Carassius auratus exposed to acesulfame and its UV irradiance products.
abstract: Acesulfame (ACE) is listed as an emerging contaminant due to its environmental persistence and wide occurrence in the environment. ACE can be degraded partially in the regular UV disinfection process but the eco-toxicity of its irradiation products remains unclear. This study focused on the possible oxidative status change in the liver of Carassius auratus exposed to ACE and its irradiation products. The UV degradation of ACE follows pseudo-first-order kinetics, and eight irradiation products were identified. Fish were exposed 7days to 0.1 and 10mg/L ACE (ACE group) and ACE after UV irradiance (ACE-UV group). The oxidative stress in fish liver exposed to ACE group had no distinct change. However, in the ACE-UV group, the quantity of OH was induced by 17.96-55% and the MDA content increased by 16.28-68.28% compared to control. Time-effect exposure in the ACE-UV group showed that in the first 3days the quantity of OH reached its peak, causing severe inhibition of SOD and continuous inducement of GPx. GSH helped scavenge OH and decreased below control after 3days. An increased toxicity of ACE after UV irradiance was observed and its transfer after into aquatic environment needs to be recognized as an environmental risk.
authors.affiliation: State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210023, People's Republic of China.
authors.forename: Yuhang
authors.initials: Y
authors.lastname: Ren
authors.affiliation: State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210023, People's Republic of China. Electronic address: jjgeng@nju.edu.cn.
authors.forename: Jinju
authors.initials: J
authors.lastname: Geng
authors.affiliation: State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210023, People's Republic of China.
authors.forename: Fuchang
authors.initials: F
authors.lastname: Li
authors.affiliation: State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210023, People's Republic of China.
authors.forename: Hongqiang
authors.initials: H
authors.lastname: Ren
authors.affiliation: State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210023, People's Republic of China.
authors.forename: Lili
authors.initials: L
authors.lastname: Ding
authors.affiliation: State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210023, People's Republic of China.
authors.forename: Ke
authors.initials: K
authors.lastname: Xu
mesh_terms: D000818:Animals; D006054:Goldfish / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D018384:Oxidative Stress; D011897:Random Allocation; D013549:Sweetening Agents / Q000633:toxicity*; D013843:Thiazines / Q000528:radiation effects / Q000633:toxicity*; D014466:Ultraviolet Rays; D014874:Water Pollutants, Chemical / Q000528:radiation effects / Q000633:toxicity*
chemical_list: D013549:Sweetening Agents; D013843:Thiazines; D014874:Water Pollutants, Chemical; C006362:acetosulfame
keywords: Artificial sweeteners; Eco-toxicity; Hydroxyl radical; UV irradiance