title: Copper-catalysed oxidative amination of quinoxalin-2(1H)-ones with aliphatic amines.
abstract: A novel, efficient and practical method for copper-catalysed oxidative C-3 amination of quinoxalin-2(1H)-ones with primary or secondary amines as the nitrogen sources has been developed. A wide variety of 3-aminoquinoxalin-2(1H)-ones were prepared in up to 98% yield with good functional group tolerance for 24 examples. This synthetic strategy features atom economy, concise steps, easy operation, and mild reaction conditions.
authors.affiliation: Engineering Research Center of Molecular Medicine, Ministry of Education, Key Laboratory of Molecular Medicine of Fujian Province, Key Laboratory of Xiamen Marine and Gene Drugs, Institutes of Molecular Medicine and School of Biomedical Sciences, Huaqiao University, Xiamen, 361021, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.forename: Ming
authors.initials: M
authors.lastname: Gao
authors.forename: Lianhui
authors.initials: L
authors.lastname: Wang
authors.forename: Xiuling
authors.initials: X
authors.lastname: Cui