title: Bilateral central serous retinopathy in a patient with paroxysmal nocturnal hemoglobinuria treated with deferoxamine.
abstract: OBJECTIVE
  To report a case of acute bilateral central serous retinopathy associated with deferoxamine therapy in the context of paroxysmal nocturnal hemoglobinuria.
  
  
  METHODS
  Spectral-domain optical coherence tomography and fundus autofluorescence were used to investigate posterior segment changes.
  
  
  RESULTS
  A 76-year-old man with paroxysmal nocturnal hemoglobinuria and hereditary spherocytosis was started on deferoxamine for iron overload secondary to previous blood transfusions. Four days after initiation of treatment, he developed bilateral reduced vision and metamorphopsia. He was noted to have bilateral central serous retinopathy. Symptoms and serous retinal detachment resolved rapidly following discontinuation of treatment.
  
  
  CONCLUSIONS
  This case represents the first report of acute bilateral central serous retinopathy associated with deferoxamine therapy. Cessation of deferoxamine resulted in rapid visual recovery.
authors.affiliation:  Royal Eye Infirmary, Derriford Hospital, Plymouth - UK.
authors.forename: Kaveh
authors.initials: K
authors.lastname: Vahdani
authors.affiliation:  Bristol Eye Hospital, Bristol - UK.
authors.forename: Georgios
authors.initials: G
authors.lastname: Makrygiannis
authors.affiliation:  Royal Eye Infirmary, Derriford Hospital, Plymouth - UK.
authors.forename: Harikesh
authors.initials: H
authors.lastname: Kaneshyogan
authors.affiliation:  Ophthalmology Department, Torbay Hospital, Torquay, Devon - UK.
authors.forename: Inderpaul S
authors.initials: IS
authors.lastname: Sian
authors.affiliation:  Ophthalmology Department, Singleton Hospital, Sketty, Swansea - UK.
authors.forename: Osama
authors.initials: O
authors.lastname: Giasin
mesh_terms: D056833:Central Serous Chorioretinopathy / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000503:physiopathology; D003676:Deferoxamine / Q000009:adverse effects*; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006457:Hemoglobinuria, Paroxysmal / Q000188:drug therapy*; D006801:Humans; D019190:Iron Overload / Q000188:drug therapy; D008297:Male; D017262:Siderophores / Q000009:adverse effects*; D041623:Tomography, Optical Coherence / Q000379:methods; D014786:Vision Disorders / Q000139:chemically induced / Q000503:physiopathology; D015354:Vision, Low / Q000139:chemically induced / Q000503:physiopathology; D014792:Visual Acuity / Q000187:drug effects
chemical_list: D017262:Siderophores; D003676:Deferoxamine