title: EMT in Breast Carcinoma-A Review.
abstract: The epithelial to mesenchymal transition (EMT) is a cellular program that is involved in embryonic development; wound healing, but also in tumorigenesis. Breast carcinoma (BC) is the most common cancer in women worldwide, and the majority of deaths (90%) are caused by invasion and metastasis. The EMT plays an important role in invasion and subsequent metastasis. Several distinct biological events integrate a cascade that leads not only to a change from an epithelial to mesenchymal phenotype, but allows for detachment, migration, invasion and ultimately, colonization of a second site. Understanding the biological intricacies of the EMT may provide important insights that lead to the development of therapeutic targets in pre-invasive and invasive breast cancer, and could be used as biomarkers identifying tumor subsets with greater chances of recurrence, metastasis and therapeutic resistance leading to death.
authors.affiliation: Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada. joema.lima@oicr.on.ca.|Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada. joema.lima@oicr.on.ca.
authors.forename: Joema
authors.initials: J
authors.lastname: Felipe Lima
authors.affiliation: Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada. sharon.nofech-mozes@sunnybrook.ca.
authors.forename: Sharon
authors.initials: S
authors.lastname: Nofech-Mozes
authors.affiliation: Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada. jane.bayani@oicr.on.ca.
authors.forename: Jane
authors.initials: J
authors.lastname: Bayani
authors.affiliation: Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada. john.bartlett@oicr.on.ca.
authors.forename: John M S
authors.initials: JM
authors.lastname: Bartlett
keywords: EMT; breast; cancer; invasion; metastasis