title: Resting-state functional MR imaging shed insights into the brain of diabetes.
abstract: Diabetes mellitus is a common metabolic disease which is associated with increasing risk for multiple cognitive declines. Alterations in brain functional connectivity are believed to be the mechanisms underlying the cognitive function impairments. During the past decade, resting-state functional magnetic resonance imaging (rs-fMRI) has been developed as a major tool to study brain functional connectivity in vivo. This paper briefly reviews the diabetes-associated cognitive impairment, analysis algorithms and clinical applications of rs-fMRI. We also provide future perspectives of rs-fMRI in diabetes.
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, No. 305 Zhongshan East Road, Nanjing, Jiangsu Province, 210002, China.
authors.forename: Yun Fei
authors.initials: YF
authors.lastname: Wang
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, No. 305 Zhongshan East Road, Nanjing, Jiangsu Province, 210002, China. jixueman@126.com.
authors.forename: Xue Man
authors.initials: XM
authors.lastname: Ji
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, No. 305 Zhongshan East Road, Nanjing, Jiangsu Province, 210002, China.
authors.forename: Guang Ming
authors.initials: GM
authors.lastname: Lu
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, No. 305 Zhongshan East Road, Nanjing, Jiangsu Province, 210002, China. kevinzhlj@163.com.
authors.forename: Long Jiang
authors.initials: LJ
authors.lastname: Zhang
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism; D003920:Diabetes Mellitus / Q000000981:diagnostic imaging* / Q000378:metabolism; D003929:Diabetic Neuropathies / Q000000981:diagnostic imaging / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D012146:Rest / Q000502:physiology
keywords: Cognition disorders; Diabetes mellitus; Magnetic resonance imaging; Type 1 diabetes mellitus; Type 2 diabetes mellitus