title: Lignans from the Twigs of Euonymus alatus (Thunb.) Siebold and Their Biological Evaluation.
abstract: A new sesquilignan, euonymolin A (1), and six known lignans, (-)-de-O-methylmagnolin (2), (+)-de-O-methylepimagnolin A (3), (+)-syringaresinol (4), (+)-pinoresinol (5), (+)-medioresinol (6), and (+)-lariciresinol 4'-O-β-d-glucopyranoside (7), were isolated from the twigs of Euonymus alatus (Thunb.) Siebold (Celastraceae). The structures of the isolated compounds were elucidated based on spectroscopic analyses, including extensive 1D- and 2D-NMR techniques, HR-MS analysis and circular dichroism (CD) data, and the literature data. All of the isolated compounds were evaluated for antiproliferative activity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines and inhibition of nitric oxide (NO) production in a lipopolysaccharide (LPS)-activated BV2 cell line. All compounds showed cytotoxicity against the SK-MEL-2 cell line with IC50values of 23.24 - 48.14 μm and inhibited NO production in LPS-activated BV-2 cells with IC50values of 6.75 - 23.53 μm.
authors.affiliation: School of Pharmacy, Sungkyunkwan University, Suwon, 440-746, Korea.
authors.forename: Seulah
authors.initials: S
authors.lastname: Lee
authors.affiliation: Charmzone R&D Center, Charmzone Co., Ltd., 318 Yeongdong-daero, Gangnam-gu, Seoul, 06177, Korea.
authors.forename: Eunjung
authors.initials: E
authors.lastname: Moon
authors.affiliation: Korea Research Institute of Chemical Technology, Deajeon, 305-600, Korea.
authors.forename: Sang Un
authors.initials: SU
authors.lastname: Choi
authors.affiliation: School of Pharmacy, Sungkyunkwan University, Suwon, 440-746, Korea. khkim83@skku.edu.
authors.forename: Ki Hyun
authors.initials: KH
authors.lastname: Kim
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D029756:Euonymus / Q000737:chemistry*; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors / Q000494:pharmacology; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis*; D018547:Plant Stems / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017705:Lignans; D008070:Lipopolysaccharides; D009569:Nitric Oxide
keywords: 
  Euonymus alatus
  ; Cytotoxicity; Euonymolin A; Lignans; Nitric oxide