title: Different in vitro and in vivo behaviors between Poly(carboxybetaine methacrylate) and poly(sulfobetaine methacrylate).
abstract: Poly(sulfobetaine methacrylate) (pSBMA) and poly(carboxybetaine methacrylate) (pCBMA) are two well-known zwitterionic polymers known for their excellent antifouling properties. In this work, these two zwitterionic polymers were compared both in vitro and in vivo. Both of them exhibited excellent antifouling properties and low macrophage uptake although there were negligible differences in resistance to nonspecific protein adsorption of their hydrogels and cell internalization of their star polymers. However, it is found that the β- Cyclodextrin-CBMA (CD-CBMA) showed a circulation time one order of magnitude longer than CD-SBMA, which implied that small differences in vitro may lead to a dramatic difference in vivo. This work demonstrated that pCBMA showed greater potential than pSBMA in biomedical applications.
authors.affiliation: Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China.
authors.forename: Weifeng
authors.initials: W
authors.lastname: Lin
authors.affiliation: Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China.
authors.forename: Guanglong
authors.initials: G
authors.lastname: Ma
authors.affiliation: School of Pharmaceutical Sciences Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Wu
authors.affiliation: Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China; Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Biomedical Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210046, China. Electronic address: schen@zju.edu.cn.
authors.forename: Shengfu
authors.initials: S
authors.lastname: Chen
mesh_terms: D000178:Acrylamides / Q000737:chemistry*; D000327:Adsorption; D000818:Animals; D005260:Female; D020100:Hydrogels / Q000737:chemistry*; D066298:In Vitro Techniques; D008689:Methacrylates / Q000737:chemistry*; D051379:Mice; D008813:Mice, Inbred ICR; D011108:Polymers / Q000737:chemistry*; D000067996:RAW 264.7 Cells; D013499:Surface Properties
chemical_list: D000178:Acrylamides; D020100:Hydrogels; D008689:Methacrylates; D011108:Polymers; C533866:poly(carboxybetaine acrylamide); C521589:sulfobetaine methacrylate polymer
keywords: Antifouling; Carboxybetaine; Circulation time; Sulfobetaine; Zwitterionic polymer