title: Moisturizing Effects of Diglycerol Combined with Glycerol on Human Stratum Corneum.
abstract: The water content of the stratum corneum was measured to investigate the skin-moisturizing property of diglycerol in water and in a lotion. The water content of the stratum corneum, to which the diglycerol solution was applied, was lower than that of the glycerol solution for 8 h. However, skin treated with diglycerol in combination with glycerol solution maintained a higher capacitance level compared with that of glycerol solution alone after 8 h. Moreover, the long-term moisturizing effect of the stratum corneum prominently appeared when diglycerol was formulated to the lotion containing glycerol and 1,3-butylene glycol. These studies suggest that diglycerol in combination with glycerol has a long-term moisturizing effect on human skin.
authors.affiliation: Sakamoto Yakuhin Kogyo Co., Ltd. Laboratory.
authors.forename: Ai
authors.initials: A
authors.lastname: Tomiie
authors.forename: Masami
authors.initials: M
authors.lastname: Shinozaki
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yamada
authors.forename: Juhei
authors.initials: J
authors.lastname: Kuriyama
mesh_terms: D000328:Adult; D002072:Butylene Glycols / Q000737:chemistry / Q000494:pharmacology*; D004075:Diglycerides / Q000737:chemistry* / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D005990:Glycerol / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D011897:Random Allocation; D012867:Skin / Q000187:drug effects*; D063465:Skin Cream / Q000737:chemistry* / Q000494:pharmacology*; D012879:Skin Physiological Phenomena / Q000187:drug effects; D012996:Solutions; D013997:Time Factors
chemical_list: D002072:Butylene Glycols; D004075:Diglycerides; D012996:Solutions; C028491:1,3-butylene glycol; D005990:Glycerol