title: Improved Treatment of Photothermal Cancer by Coating TiO2 on Porous Silicon.
abstract: In present society, the technology in various field has been sharply developed and advanced. In medical technology, especially, photothermal therapy and photodynamic therapy have had limelight for curing cancers and diseases. The study investigates the photothermal therapy that reduces side effects of existing cancer treatment, is applied to only cancer cells, and dose not harm any other normal cells. The photothermal properties of porous silicon for therapy are analyzed in order to destroy cancer cells that are more weak at heat than normal ones. For improving performance of porous silicon, it also analyzes the properties when irradiating the near infrared by heterologously junction TiO2 and TiO2NW, photocatalysts that are very stable and harmless to the environment and the human body, to porous silicon. Each sample of Si, PSi, TiO2/Psi, and TiO2NW/PSi was irradiated with 808 nm near-IR of 300, 500, and 700 mW/cm2 light intensity, where the maximum heating temperature was 43.8, 61.6, 67.9, and 61.9 degrees C at 300 mW/cm2; 54.1, 64.3, 78.8, and 68.9 degrees C at 500 mW/cm2; and 97.3, 102.8, 102.5, and 95 0C at 700 mW/cm2. The time required to reach the maximum temperature was less than 10 min for every case. The results indicate that TiO2/PSi thin film irradiated with a single near-infrared wavelength of 808 nm, which is known to have the best human permeability, offers the potential of being the most successful photothermal cancer therapy agent. It maximizes the photo-thermal characteristics within the shortest time, and minimizes the adverse effects on the human body.
authors.forename: Kil Ju
authors.initials: KJ
authors.lastname: Na
authors.forename: Gye-Choon
authors.initials: GC
authors.lastname: Park
mesh_terms: D006801:Humans; D007259:Infrared Rays / Q000627:therapeutic use; D010789:Phototherapy / Q000379:methods; D016062:Porosity; D012825:Silicon / Q000737:chemistry* / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000628:therapy; D014025:Titanium / Q000737:chemistry* / Q000627:therapeutic use
chemical_list: C009495:titanium dioxide; D014025:Titanium; D012825:Silicon