title: Use of Vancomycin-Impregnated Calcium Sulfate in the Treatment of Osteomyelitis of the Jaw.
abstract: OBJECTIVE
  The aim of this study was to describe the effect of vancomycin-impregnated calcium sulfate in the treatment of osteomyelitis of the jaw.
  
  
  METHODS
  Twelve patients who were diagnosed with osteomyelitis of the jaw underwent treatment with vancomycin-impregnated calcium sulfate since July 2014 at the Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University (Shenyang, China). All patients underwent debridement of nonviable bone and implantation of vancomycin-impregnated calcium sulfate. The wounds were covered with an acellular dermal matrix and sutured.
  
  
  RESULTS
  Ten patients had satisfactory wound healing. However, 2 cases of maxillary central osteomyelitis had delayed wound healing. The wounds healed after the surgical site was resutured under local anesthesia. At 3 months, the panoramic radiograph showed that most implants had been reabsorbed and replaced by new bone formation. All patients in this study had no recurrence of infection at 6 to 18 months (mean, 10.8 months) of follow-up.
  
  
  CONCLUSIONS
  The use of vancomycin-impregnated calcium sulfate in the surgical debridement site for chronic osteomyelitis of the jaw has shown encouraging results. In addition, calcium sulfate can promote the formation of new bone to a certain extent.
authors.affiliation: Resident, Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Liaoning Institute of Dental Research, Shenyang, Liaoning Province, China.
authors.forename: Hai-Jiang
authors.initials: HJ
authors.lastname: Sun
authors.affiliation: Attending Physician, Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Liaoning Institute of Dental Research, Shenyang, Liaoning Province, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Xue
authors.affiliation: Resident, Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Liaoning Institute of Dental Research, Shenyang, Liaoning Province, China.
authors.forename: Chuan-Bin
authors.initials: CB
authors.lastname: Wu
authors.affiliation: Professor, Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Liaoning Institute of Dental Research, Shenyang, Liaoning Province, China. Electronic address: zqforstudent@163.com.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhou
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002133:Calcium Sulfate / Q000008:administration & dosage / Q000627:therapeutic use*; D003646:Debridement / Q000009:adverse effects / Q000379:methods; D005260:Female; D006801:Humans; D007571:Jaw Diseases / Q000188:drug therapy* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000188:drug therapy* / Q000601:surgery; D016896:Treatment Outcome; D014640:Vancomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D014945:Wound Healing / Q000187:drug effects; D055815:Young Adult
chemical_list: D014640:Vancomycin; D002133:Calcium Sulfate