title: Colon Cancer in the Land of NOD: NLRX1 as an Intrinsic Tumor Suppressor.
abstract: Although best known for inducing inflammasome formation and pyroptosis in myeloid cells, increasing evidence highlights additional roles for Nod-like receptors (NLR) in nonhematopoietic cells. Two recent studies demonstrate that NLRX1 functions as an intrinsic tumor suppressor in intestinal epithelial cells (IEC), by regulating their responses to proliferative signals following intestinal injury.
authors.affiliation: Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK.
authors.forename: Andrea
authors.initials: A
authors.lastname: Lei
authors.affiliation: Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK. Electronic address: kevin.maloy@path.ox.ac.uk.
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Maloy
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D003110:Colonic Neoplasms / Q000276:immunology*; D005756:Gastritis / Q000276:immunology*; D006706:Homeostasis; D006801:Humans; D007113:Immunity, Innate; D007413:Intestinal Mucosa / Q000378:metabolism* / Q000473:pathology; D008581:Meningitis / Q000276:immunology*; D051379:Mice; D018345:Mice, Knockout; D024101:Mitochondrial Proteins / Q000235:genetics / Q000378:metabolism*; D011014:Pneumonia / Q000276:immunology*; D015398:Signal Transduction; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D024101:Mitochondrial Proteins; C527006:NLRX1 protein, human; D025521:Tumor Suppressor Proteins