title: Breast metastasis from vaginal cancer.
abstract: Vaginal cancer is a rare malignancy accounting for 1-2% of all pelvic neoplasms. Dissemination usually occurs through local invasion and rarely metastasises to distal locations. Metastasis of vaginal cancer to the breast is extremely infrequent and unique. A 66-year-old Asian woman presented with vaginal bleeding and was found to have a vaginal mass and a left breast mass. Pathological assessment of the biopsies revealed identical squamous cell characteristics of both masses. We describe a very rare and novel case of a distally located vaginal carcinoma with metastasis to the breast Federation of Gynecology and Obstetrics (FIGO) stage IV (FIGO IVB). Robot-assisted extrafascial total hysterectomy with local vaginal mass excision and partial mastectomy of the left breast were performed. After surgery, the patient underwent adjuvant chemotherapy followed by breast and pelvic radiotherapy, with maintained complete remission after 3 years of follow-up. This combination of findings and treatment is very distinct with a unique and favourable response.
authors.affiliation: Cleveland Clinic Florida, Weston, Florida, USA.
authors.forename: Neeraja
authors.identifier: http://orcid.org/0000-0002-0579-5549
authors.initials: N
authors.lastname: Chandrasekaran
authors.affiliation: Department of Pathology, West Boca Medical Center, Boca Raton, Florida, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Scharifker
authors.affiliation: Department of Pathology, West Boca Medical Center, Boca Raton, Florida, USA.
authors.forename: George
authors.initials: G
authors.lastname: Varsegi
authors.affiliation: Department of Gynecologic Oncology, West Boca Medical Center, Boca Raton, Florida, USA.
authors.forename: Zoyla
authors.initials: Z
authors.lastname: Almeida
mesh_terms: D000368:Aged; D001706:Biopsy; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000556:secondary* / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016896:Treatment Outcome; D014625:Vaginal Neoplasms / Q000473:pathology* / Q000628:therapy