title: Programmable carbon nanotube membrane-based transdermal nicotine delivery with microdialysis validation assay.
abstract: To evaluate the performance of switchable carbon nanotubes (CNT) membrane devices for transdermal nicotine delivery, we have developed an in-vitro microdialysis method that allow us to detect variable transdermal fluxes of nicotine through CNT devices and can be applied directly to in-vivo studies. Microdialysis membranes were placed beneath the porcine skin and its nicotine levels increased 6-8 times when the CNT membrane on skin was turned from OFF to ON state by application of bias. Fluxes in the ON state were approximately 3 times that of commercial nicotine patches and switching times were less than two hours, thus suggesting the improved therapeutic potential of our device. Blue tooth enabled CNT devices that can be programmed by smartphone and coupled with remote counseling application for enhanced smoking cessation treatments.
authors.affiliation: Materials Science and Engineering, University of Washington, Seattle, WA, USA.
authors.forename: Gaurav Kumar
authors.initials: GK
authors.lastname: Gulati
authors.affiliation: Chemical and Materials Engineering, University of Kentucky, Lexington, KY, USA.
authors.forename: Tao
authors.initials: T
authors.lastname: Chen
authors.affiliation: Materials Science and Engineering, University of Washington, Seattle, WA, USA. Electronic address: bjhinds@uw.edu.
authors.forename: Bruce Jackson
authors.initials: BJ
authors.lastname: Hinds
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D016503:Drug Delivery Systems; D017551:Microdialysis; D037742:Nanotubes, Carbon / Q000737:chemistry*; D009538:Nicotine / Q000008:administration & dosage* / Q000627:therapeutic use; D012867:Skin; D013552:Swine; D061485:Tobacco Use Cessation Devices
chemical_list: D037742:Nanotubes, Carbon; D009538:Nicotine
keywords: CNT membrane; Microdialysis; Nicotine; Remote counseling; Smoking cessation