title: Quetiapine adverse events in older adults in Australia.
abstract: OBJECTIVE
  To characterise quetiapine reported adverse drug events (ADEs) in older Australians in terms of type, frequency, severity and outcome, and to compare these characteristics with those of younger Australians.
  
  
  METHODS
  Basic descriptive analyses were used to examine patient characteristics. The characteristics of reported ADEs were compared between older and younger Australians using odds ratios and chi-squared tests.
  
  
  RESULTS
  The most frequently reported ADEs in older people were nervous system disorders (23.7%). There were significantly more reports of skin and subcutaneous ADEs and hepatobiliary ADEs for older people than for younger people. More severe ADEs were reported in older people with death more likely to occur in older than in younger people CONCLUSION: Significant differences between older and younger people in terms of reported ADEs, severity and mortality were found. There is a need for further prospective studies in older people on quetiapine to confirm the findings of this study.
authors.affiliation: Menzies Health Institute Queensland, Griffith University, Brisbane, Queensland, Australia.
authors.forename: Najwan
authors.initials: N
authors.lastname: El-Saifi
authors.affiliation: Menzies Health Institute Queensland, Griffith University, Brisbane, Queensland, Australia.|Centre for Health Practice Innovation, Griffith University, Brisbane, Queensland, Australia.
authors.forename: Cindy
authors.initials: C
authors.lastname: Jones
authors.affiliation: Menzies Health Institute Queensland, Griffith University, Brisbane, Queensland, Australia.|Centre for Health Practice Innovation, Griffith University, Brisbane, Queensland, Australia.
authors.forename: Wendy
authors.initials: W
authors.lastname: Moyle
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001315:Australia / Q000453:epidemiology; D016009:Chi-Square Distribution; D064420:Drug-Related Side Effects and Adverse Reactions / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D000069348:Quetiapine Fumarate / Q000009:adverse effects*; D012307:Risk Factors; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D000069348:Quetiapine Fumarate
keywords: adverse event; aged; antipsychotic