title: Clinical Outcome and Characterization of Local Field Potentials in Holmes Tremor Treated with Pallidal Deep Brain Stimulation.
abstract: BACKGROUND
  Holmes tremor (HT) is an irregular, low-frequency rest tremor associated with prominent action and postural tremors. Currently, the most effective stereotactic target and neurophysiologic characterization of HT, specifically local field potentials (LFPs) are uncertain. We present the outcome, intraoperative neurophysiologic analysis with characterization of LFPs in a patient managed with left globus pallidus interna deep brain stimulation (Gpi DBS).
  
  
  METHODS
  A 24-year-old male underwent left Gpi DBS for medically refractory HT. LFPs demonstrated highest powers in the delta range in Gpi. At the 6-month follow-up, a 90% reduction in tremor was observed.
  
  
  CONCLUSIONS
  Pallidal DBS should be considered as an alternative target for management of refractory HT. LFP demonstrated neuronal activity associated with higher power in the delta region, similarly seen in patients with generalized dystonia.
authors.affiliation: Albany Medical Center, Albany, NY, USA.
authors.forename: Adolfo
authors.initials: A
authors.lastname: Ramirez-Zamora
authors.affiliation: Albany Medical College, Albany, NY, USA.
authors.forename: Brian C
authors.initials: BC
authors.lastname: Kaszuba
authors.affiliation: Albany Medical College, Albany, NY, USA.
authors.forename: Lucy
authors.initials: L
authors.lastname: Gee
authors.affiliation: Albany Medical Center, Albany, NY, USA.
authors.forename: Julia
authors.initials: J
authors.lastname: Prusik
authors.affiliation: Kingston Neurological Associates, Kingston, NY, USA.
authors.forename: Fabio
authors.initials: F
authors.lastname: Danisi
authors.affiliation: Albany Medical College, Albany, NY, USA.
authors.forename: Damian
authors.initials: D
authors.lastname: Shin
authors.affiliation: Albany Medical Center, Albany, NY, USA; Albany Medical College, Albany, NY, USA.
authors.forename: Julie G
authors.initials: JG
authors.lastname: Pilitsis
keywords: Deep Brain Stimulation (DBS); Globus pallidus; Holmes Tremor (HT); Internal Arterio-Venous Fistula; Local Field Potentials (LFP); Power Spectral Densities (PSD)