title: Depression and anxiety in patients receiving interferon-alpha: The role of illness perceptions.
abstract: Development of psychiatric symptoms during interferon-alpha therapy may be influenced by psychological factors. We examined illness perceptions using the Revised Illness Perceptions Questionnaire in 55 patients with chronic hepatitis C virus infection, due to receive interferon-alpha. The Hospital Anxiety and Depression Scale was used to assess the development of symptoms. Negative identity, consequences and emotional representation beliefs were significantly associated with both higher depression and anxiety scores. Negative illness perceptions play a predictive role in the development of interferon-alpha-induced psychiatric symptoms.
authors.affiliation: 1 King's College London, UK.
authors.forename: Nilay
authors.initials: N
authors.lastname: Hepgul
authors.affiliation: 1 King's College London, UK.
authors.forename: Carmine M
authors.initials: CM
authors.lastname: Pariante
authors.affiliation: 1 King's College London, UK.
authors.forename: Sara
authors.initials: S
authors.lastname: Baraldi
authors.affiliation: 1 King's College London, UK.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Borsini
authors.affiliation: 1 King's College London, UK.
authors.forename: Chiara
authors.initials: C
authors.lastname: Bufalino
authors.affiliation: 1 King's College London, UK.
authors.forename: Alice
authors.initials: A
authors.lastname: Russell
authors.affiliation: 2 King's College Hospital, UK.
authors.forename: Kosh
authors.initials: K
authors.lastname: Agarwal
authors.affiliation: 1 King's College London, UK.
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Cleare
authors.affiliation: 3 St George's Hospital, UK.
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Forton
authors.affiliation: 1 King's College London, UK.|2 King's College Hospital, UK.
authors.forename: Max
authors.initials: M
authors.lastname: Henderson
authors.affiliation: 1 King's College London, UK.
authors.forename: Valeria
authors.initials: V
authors.lastname: Mondelli
authors.affiliation: 4 South London and Maudsley NHS Foundation Trust, UK.
authors.forename: Gopinath
authors.initials: G
authors.lastname: Ranjith
authors.affiliation: 1 King's College London, UK.
authors.forename: Matthew
authors.initials: M
authors.lastname: Hotopf
mesh_terms: D000328:Adult; D001007:Anxiety / Q000139:chemically induced*; D003863:Depression / Q000139:chemically induced*; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D007155:Immunologic Factors / Q000009:adverse effects*; D016898:Interferon-alpha / Q000009:adverse effects*; D008297:Male; D001523:Mental Disorders / Q000139:chemically induced*
chemical_list: D007155:Immunologic Factors; D016898:Interferon-alpha
keywords: anxiety; depression; illness perceptions; mood; psychological distress; side effects