title: [Study of two cases of prenatally detected small supernumerary marker chromosomes].
abstract: OBJECTIVE
  To determine the origin of two prenatally detected small supernumerary marker chromosomes (sSMCs).
  
  
  METHODS
  The sSMCs were analyzed with combined G-banding, C-banding, fluorescence in situ hybridization (FISH), and single nucleotide polymorphisms array (SNP-array) techniques.
  
  
  RESULTS
  In case 1, G-banding analysis has identified a 47,XY,+mar karyotype. Affymetrix CytoScan 750K Array scan has suggested arr 15q11.2q12(22 770 421-26 604 587)?, while FISH analysis suggested 47,XN,+mar.ish i(15)(q12)(D15Z1+,SNRPN++,PML-). In case 2, G-banding analysis has suggested 46,X,+mar/46,XY, FISH analysis showed two SRY hybridization signals, indicating 46,X,i(Y)(p10)/46,XY.
  
  
  CONCLUSIONS
  Multiple techniques needed be applied for verification of the origin of sSMCs identified in prenatal diagnosis.
authors.affiliation: Genetics Laboratory, Shaoxing Women and Children's Hospital, Shaoxing, Zhejiang 312000, China. Email: 2560336019@qq.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zeng
authors.forename: Jiaming
authors.initials: J
authors.lastname: Fan
authors.forename: Ping
authors.initials: P
authors.lastname: Xu
authors.forename: Lifang
authors.initials: L
authors.lastname: Zhang
authors.forename: Feiyan
authors.initials: F
authors.lastname: Qian
authors.forename: Tingting
authors.initials: T
authors.lastname: Luo
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D005260:Female; D005819:Genetic Markers; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D060885:Multiplex Polymerase Chain Reaction; D020411:Oligonucleotide Array Sequence Analysis; D020641:Polymorphism, Single Nucleotide; D011296:Prenatal Diagnosis
chemical_list: D005819:Genetic Markers