title: Thermodynamic and Structural Impact of α,α-Dialkylated Residue Incorporation in a β-Hairpin Peptide.
abstract: Peptides containing α,α-dialkylated α-amino acids, owing to their ability to disrupt aggregation of β-amyloid proteins, have therapeutic potential in the treatment of neurodegenerative diseases. Thermodynamic and structural analyses are reported for a series of β-hairpin peptides containing α,α-dialkylated α-amino acids with varying side-chain lengths. The results of these experiments show that α,α-dialkylated α-amino acids with side-chain lengths longer than one carbon unit are tolerated in a β-hairpin, although at a moderate cost to folded stability.
authors.affiliation: Department of Chemistry, Slippery Rock University , Slippery Rock, Pennsylvania 16057, United States.
authors.forename: Megan A
authors.initials: MA
authors.lastname: Karnes
authors.affiliation: Department of Chemistry, Slippery Rock University , Slippery Rock, Pennsylvania 16057, United States.
authors.forename: Shelby L
authors.initials: SL
authors.lastname: Schettler
authors.affiliation: Department of Chemistry, University of Pittsburgh , Pittsburgh, Pennsylvania 15260, United States.
authors.forename: Halina M
authors.initials: HM
authors.lastname: Werner
authors.affiliation: Department of Chemistry, University of Pittsburgh , Pittsburgh, Pennsylvania 15260, United States.
authors.forename: Alana F
authors.initials: AF
authors.lastname: Kurz
authors.affiliation: Department of Chemistry, University of Pittsburgh , Pittsburgh, Pennsylvania 15260, United States.
authors.forename: W Seth
authors.initials: WS
authors.lastname: Horne
authors.affiliation: Department of Chemistry, Slippery Rock University , Slippery Rock, Pennsylvania 16057, United States.
authors.forename: George A
authors.initials: GA
authors.lastname: Lengyel
mesh_terms: D000478:Alkylation; D000596:Amino Acids / Q000737:chemistry*; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry*; D011487:Protein Conformation; D017510:Protein Folding; D055550:Protein Stability; D013816:Thermodynamics
chemical_list: D000596:Amino Acids; D010455:Peptides