title: Inflammatory markers and cardiovascular risks among overweight-obese Emirati women.
abstract: BACKGROUND
  The prevalence of abdominal obesity among women in UAE is exceptionally high. However, its impact on cardiovascular health has not been adequately investigated. The aims of this study were to investigate: (1) correlations between inflammatory and oxidative biomarkers vs. anthropometric and metabolic measures; (2) rates of dyslipidemia, diabetes, and hypertension and (3) risks of cardiovascular disease.
  
  
  METHODS
  One hundred ten "healthy" overweight/obese Emirati women attending nutrition counselling clinics were randomly recruited. All participants had completed questionnaire, physical examination and laboratory assessment.
  
  
  RESULTS
  The participants' mean ± SD of age, body mass-index, waist circumference were 39 ± 9 years, 34 ± 6 kg/m(2) and 100 ± 13 cm respectively. Among the studied women 45 % met diagnostic criteria for metabolic syndrome showing a positive correlation of hsCRP with BMI (p = 0.002), body fat (p = 0.002) and waist circumference (p = 0.018). There was positive correlation of IL-6 with waist circumference (p = 0.019) and adiponectin with HDL (p = 0.007). Prevalence of HDL <1.3 mmol/L or triglycerides ≥1.7 mmol/L were 82 %, dysglycemia 31 %, and hypertension 27 and 37 % of women had either 'high' or 'moderate' calculated cardiovascular 10-year risk score.
  
  
  CONCLUSIONS
  The levels of inflammatory and oxidative stress markers were highly prevalent among overweight/obese Emirati women and this may predispose to increasing cardiovascular risks at relatively young age. Thus effective strategies to impact cardiovascular burden and conducting outcome studies assessing the increased risk of cardiovascular disease and addressing obesity prevention among women are urgently needed.
authors.affiliation: Department of Internal Medicine, College of Medicine and Health Sciences, UAE University, P.O. Box 17666, Al-Ain, United Arab Emirates. j.kaabi@uaeu.ac.ae.
authors.forename: Juma
authors.initials: J
authors.lastname: Alkaabi
authors.affiliation: Department of Internal Medicine, College of Medicine and Health Sciences, UAE University, P.O. Box 17666, Al-Ain, United Arab Emirates.
authors.forename: Salah
authors.initials: S
authors.lastname: Gariballa
authors.affiliation: Department of Internal Medicine, College of Medicine and Health Sciences, UAE University, P.O. Box 17666, Al-Ain, United Arab Emirates.
authors.forename: Charu
authors.initials: C
authors.lastname: Sharma
authors.affiliation: Department of Internal Medicine, College of Medicine and Health Sciences, UAE University, P.O. Box 17666, Al-Ain, United Arab Emirates.
authors.forename: Javed
authors.initials: J
authors.lastname: Yasin
authors.affiliation: Department of Internal Medicine, College of Medicine and Health Sciences, UAE University, P.O. Box 17666, Al-Ain, United Arab Emirates.
authors.forename: Awad Al
authors.initials: AA
authors.lastname: Essa
authors.affiliation: Department of Nutrition and Health, UAE University, Al-Ain, United Arab Emirates.
authors.forename: Habiba
authors.initials: H
authors.lastname: Ali
authors.affiliation: Department of Pediatrics, College of Medicine and Health Sciences, UAE University, Al-Ain, United Arab Emirates.
authors.forename: Abdul-Kader
authors.initials: AK
authors.lastname: Souid
mesh_terms: D052242:Adiponectin / Q000097:blood; D000273:Adipose Tissue / Q000503:physiopathology; D000328:Adult; D000368:Aged; D000886:Anthropometry; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D008076:Cholesterol, HDL / Q000097:blood; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D050171:Dyslipidemias / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D006801:Humans; D007249:Inflammation; D015850:Interleukin-6 / Q000097:blood; D024821:Metabolic Syndrome / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D018384:Oxidative Stress; D012306:Risk; D014479:United Arab Emirates / Q000453:epidemiology; D055105:Waist Circumference
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; D008076:Cholesterol, HDL; C508600:IL6 protein, human; D015850:Interleukin-6; D002097:C-Reactive Protein
keywords: Cardiac function; Cardiovascular risk; Central obesity; Inflammation; Metabolic syndrome; Oxidative stress