title: A pedigree-based proxy measure of genetic predisposition of drinking and alcohol use among female sex workers in China: a cross-sectional study.
abstract: Scientific evidence has suggested that genetic factors accounted for more than half of the vulnerability of developing alcohol use problems. However, collecting genetic data poses a significant challenge for most population-based behavioral studies. The aim of this study was to assess the utilities of a pedigree-based proxy measure of genetic predisposition of drinking (GPD) and its effect on alcohol use behaviors as well as its interactions with personal and environmental factors. In the current study, cross-sectional data were collected from 700 female sex workers (FSW) in Guangxi, China. Participants provided information on a pedigree-based proxy measure of GPD and their alcohol use behaviors. Chi-square and independent t-test was applied for examining the bivariate associations between GPD and alcohol use behaviors; multivariate and ordinal regression models were used to examine the effect of GPD on alcohol use. This study found that women with a higher composite score of GPD tended to have a higher risk of alcohol use problem compared to their counterparts (p < .05). GPD was a significant predictor of alcohol use problems (p < .05), especially among women who had mental health issues or lack of health cares. The pedigree-based measure provided a useful proxy of GPD among participants. Both FSW's mental health and health care access interact with GPD and affect their drinking patterns. By understanding the genetic basis of alcohol use, we can develop scalable and efficacious interventions that will take into consideration the individual risk profile and environmental influences.
authors.affiliation: a Division of Epidemiology , Vanderbilt University , Nashville , TN , USA.
authors.forename: Chen
authors.initials: C
authors.lastname: Zhang
authors.affiliation: b Department of Health Promotion, Education, and Behavior, Arnold School of Public Health , University of South Carolina , Columbia , SC , USA.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Li
authors.affiliation: a Division of Epidemiology , Vanderbilt University , Nashville , TN , USA.
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.affiliation: b Department of Health Promotion, Education, and Behavior, Arnold School of Public Health , University of South Carolina , Columbia , SC , USA.
authors.forename: Shan
authors.initials: S
authors.lastname: Qiao
authors.affiliation: c Department of Psychology , Tuft University , Medford , MA , USA.
authors.forename: Shaobing
authors.initials: S
authors.lastname: Su
authors.affiliation: d Department of Pediatrics , Wayne State University , Detroit , MI , USA.
authors.forename: Liying
authors.initials: L
authors.lastname: Zhang
authors.affiliation: e Department of HIV/STD Prevention , Guangxi CDC , Nanning , Guangxi , China.
authors.forename: Yuejiao
authors.initials: Y
authors.lastname: Zhou
mesh_terms: D000428:Alcohol Drinking / Q000453:epidemiology* / Q000235:genetics; D000437:Alcoholism / Q000453:epidemiology* / Q000235:genetics; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D006801:Humans; D010375:Pedigree; D060386:Sex Workers
keywords: China; Genetic disposition of drinking; female sex workers