title: Analyzing spatial correlations in tissue using angle-resolved low coherence interferometry measurements guided by co-located optical coherence tomography.
abstract: Angle-resolved low coherence interferometry (a/LCI) is an optical technique used to measure nuclear morphology in situ. However, a/LCI is not an imaging modality and can produce ambiguous results when the measurements are not properly oriented to the tissue architecture. Here we present a 2D a/LCI system which incorporates optical coherence tomography imaging to guide the measurements. System design and characterization are presented, along with example cases which demonstrate the utility of the combined measurements. In addition, future development and applications of this dual modality approach are discussed.
authors.affiliation: Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
authors.forename: Sanghoon
authors.initials: S
authors.lastname: Kim
authors.affiliation: Department of Ophthalmology, Duke University, Durham, NC 27708, USA.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Heflin
authors.affiliation: Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, 53226 USA.
authors.forename: Laura A
authors.initials: LA
authors.lastname: Kresty
authors.affiliation: Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, 53226 USA.
authors.forename: Meredith
authors.initials: M
authors.lastname: Halling
authors.affiliation: Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, 53226 USA.
authors.forename: Laura N
authors.initials: LN
authors.lastname: Perez
authors.affiliation: Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
authors.forename: Derek
authors.initials: D
authors.lastname: Ho
authors.affiliation: Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Crose
authors.affiliation: Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
authors.forename: William
authors.initials: W
authors.lastname: Brown
authors.affiliation: Department of Ophthalmology, Duke University, Durham, NC 27708, USA.
authors.forename: Sina
authors.initials: S
authors.lastname: Farsiu
authors.affiliation: Department of Ophthalmology, Duke University, Durham, NC 27708, USA.
authors.forename: Vadim
authors.initials: V
authors.lastname: Arshavsky
authors.affiliation: Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
authors.forename: Adam
authors.initials: A
authors.lastname: Wax
keywords: (120.3180) Interferometry; (290.0290) Scattering; (290.3200) Inverse scattering; (290.5820) Scattering measurements