title: Cytokeratin-19 fragment in the diagnosis of bladder carcinoma.
abstract: The results of previous studies evaluated the accuracy of serum, and urinary measurements of cytokeratin-19 fragment (CYFRA 21-1) for the diagnosis of bladder cancer were inconsistent. We read with great interest the recent systematic review of diagnostic accuracy of CYFRA 21-1 for bladder cancer by Huang et al. The systematic analysis demonstrated that the pooled sensitivities and specificities for serum and urine CYFRA 21-1 were 0.42 (95 % confidence interval (CI), 0.33-0.51), 0.82 (95 % CI, 0.70-0.90), 0.94 (95 % CI, 0.90-0.96), and 0.80 (95 % CI, 0.73-0.86), respectively. Areas under the summary receiver-operating-characteristic curves for serum and urine CYFRA 21-1 were 0.88 (95 % CI, 0.85-0.91) and 0.87 (95%CI, 0.84-0.90), respectively. The authors considered that both serum and urine CYFRA 21-1 served as efficient indexes for bladder-cancer diagnosis. We congratulate and applaud their important work, but several important issues should be noted.
authors.affiliation: Department of Clinical Laboratory Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510150, China. gysygxg@gmail.com.|Department of Internal Medicine, The Third Affiliated Medical College of Guangzhou Medical University, Guangzhou, Guangdong, 510150, China. gysygxg@gmail.com.|Center for Severe Maternal Treatment of Guangzhou City, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510150, China. gysygxg@gmail.com.
authors.forename: Xu-Guang
authors.initials: XG
authors.lastname: Guo
authors.affiliation: KingMed College of Laboratory Medicine of Guangzhou Medical University, Guangzhou, Guangdong, 510182, China.|Department of Pathology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, 510120, China.
authors.forename: Jia-Jie
authors.initials: JJ
authors.lastname: Long
mesh_terms: D000951:Antigens, Neoplasm / Q000097:blood* / Q000652:urine*; D014408:Biomarkers, Tumor / Q000097:blood* / Q000652:urine*; D006801:Humans; D053539:Keratin-19 / Q000097:blood* / Q000652:urine*; D015201:Meta-Analysis as Topic; D009367:Neoplasm Staging; D011379:Prognosis; D012372:ROC Curve; D001749:Urinary Bladder Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000652:urine
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D053539:Keratin-19; C102012:antigen CYFRA21.1
keywords: Bladder cancer; Bladder carcinoma; CYFRA 21-1; Cytokeratin-19 fragment; Diagnosis