title: The Effectiveness of Budesonide Nasal Irrigation After Endoscopic Sinus Surgery in Chronic Rhinosinusitis With Asthma.
abstract: OBJECTIVE
  Budesonide nasal irrigation was introduced recently for postoperative management of patients with chronic rhinosinusitis. The safety and therapeutic effectiveness of this procedure is becoming accepted by many physicians. The objective of this study was to evaluate the efficacy of postoperative steroid irrigation in patients with chronic rhinosinusitis and asthma.
  
  
  METHODS
  This prospective study involved 12 chronic rhinosinusitis patients with nasal polyps and asthma who received oral steroid treatment for recurring or worsening disease. The 22-item Sinonasal Outcomes Test (SNOT-22) and Lund-Kennedy endoscopy scores were checked before nasal budesonide irrigation, and 1, 2, 4, and 6 months after irrigation. We also calculated the total amount of oral steroids and inhaled steroids in the 6 months before irrigation and the 6 months after it.
  
  
  RESULTS
  The mean SNOT-22 score improved from 30.8±14.4 before irrigation to 14.2±8.7 after 6 months of irrigation (P=0.030). The endoscopy score also improved from 7.4±4.7 before irrigation to 2.2±2.7 after 6 months (P<0.001). The total amount of oral steroid was decreased from 397.8±97.6 mg over the 6 months before irrigation to 72.7±99.7 mg over the 6 months after irrigation (P<0.001).
  
  
  CONCLUSIONS
  Nasal irrigation with budesonide is an effective postoperative treatment for chronic rhinosinusitis with asthma, which recurs frequently, reducing the oral steroid intake.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Hanyang University School of Medicine, Seoul, Korea.
authors.forename: Tae Wook
authors.initials: TW
authors.lastname: Kang
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Hanyang University School of Medicine, Seoul, Korea.
authors.forename: Jae Ho
authors.initials: JH
authors.lastname: Chung
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Hanyang University School of Medicine, Seoul, Korea.
authors.forename: Seok Hyun
authors.initials: SH
authors.lastname: Cho
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Hanyang University School of Medicine, Seoul, Korea.
authors.forename: Seung Hwan
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Hanyang University School of Medicine, Seoul, Korea.
authors.forename: Kyung Rae
authors.initials: KR
authors.lastname: Kim
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Hanyang University School of Medicine, Seoul, Korea.
authors.forename: Jin Hyeok
authors.initials: JH
authors.lastname: Jeong
keywords: Asthma; Budesonide; Nasal Lavage; Nasal Polyp; Sinusitis