title: Breakpoints Involved in Deletions of the Long Arm of Chromosome 5 in Myelodysplasia and Acute Non-Lymphoblastic Leukemia do not Correlate with the Morphological Diagnosis.
abstract: Recent suggestions of a correlation between the extent of acquired deletions of the long arm of chromosome 5 [del(5q)] in association with myelodysplastic syndromes and acute non-lymphoblastic leukemia, and the morphological features, prompted us to review 34 patients with these conditions and del(5q). We found no correlation between the morphological diagnosis with which the patient presented and the extent of the deletion of 5q. All cases showed involvement of band 5q31, in common with most previously reported series. The consistent involvement of 5q31 is in keeping with the concept that a single gene at band 5q31 may be involved in the pathogenesis of these myeloid clonal expansions and that the deletion of genes in the long arm of chromosome 5, known to be involved in hemopoietic growth regulation, is unlikely to be the principal determinant of the hematological disorder.
authors.affiliation: a Department of Laboratory Haematology, Sunnybrook Medical Centre University of Toronto, Ontario, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Al-Jaouni
authors.affiliation: a Department of Laboratory Haematology, Sunnybrook Medical Centre University of Toronto, Ontario, Canada.
authors.forename: P H
authors.initials: PH
authors.lastname: Pinkerton
authors.affiliation: a Department of Laboratory Haematology, Sunnybrook Medical Centre University of Toronto, Ontario, Canada.
authors.forename: B L
authors.initials: BL
authors.lastname: Sheridan
authors.affiliation: c University of Toronto Teaching Hospitals Cancer Cytogenetics Program, Department of Pathology, University of Toronto, Ontario, Canada.
authors.forename: I D
authors.initials: ID
authors.lastname: Dube
authors.affiliation: b Department of Laboratory Haematology, Wellesley Hospital University of Toronto, Ontario, Canada.
authors.forename: C S
authors.initials: CS
authors.lastname: Norman
keywords: Chromosome 5; acute leukemia; acute non-lymphoblastic leukemia; deletions; myelodysplasia