title: Effect of High Perioperative Oxygen Fraction on Surgical Site Infection Following Surgery for Acute Sigmoid Diverticulitis. A Prospective, Randomized, Double Blind, Controlled, Monocentric Trial.
abstract: Propose: The clinical role of hyperoxiato prevent postoperative surgical site infection (SSI) remains uncertain since randomized controlled trials on this topic have reported different results. One of the principal reasons for such mixed results can be that previous trials have entered a heterogeneous population of patients and set of procedures. The aim of our study was to assess the influence of hyperoxygenation on SSI usingan homogeneous study population.
  
  
  METHODS
  We studied, in a prospective randomized study, extended on a time interval January 2009 to May 2015, 85 patients who underwent open intraperitoneal anastomosis for acute sigmoid diverticulitis. Patients were assigned randomly to an oxygen/air mixture with a faction of inspiration (FiO2) of 30% (n=43) or 80% (n=42). Administration was started after induction of anesthesia and maintained for 6 hours after surgery.
  
  
  RESULTS
  The overall wound site infection rate was 24.7% (21 out of 85): 14 patients (32.5%) had a wound infection in the 30% FiO2 group and 7 (16.6%) in the 80% FiO2 group (p 0.05). The risk of SSI was 43% lower in the 80% FiO2 group (RR, 0.68; 95% confidence interval, 0.35-0.88) versus 30% FiO2.
  
  
  CONCLUSIONS
  Therefore, supplemental 80% FiO2 during and 6 hours after open surgery for acute sigmoid diverticulitis, reducing post-operative SSI, should be considered part of ongoing quality improvement activities related to surgical care, accompanied by few risk to the patients and little associates cost.
authors.forename: Mario
authors.initials: M
authors.lastname: Schietroma
authors.forename: Beatrice
authors.initials: B
authors.lastname: Pessia
authors.forename: Sara
authors.initials: S
authors.lastname: Colozzi
authors.forename: Francesco
authors.initials: F
authors.lastname: Carlei
authors.forename: Ina
authors.initials: I
authors.lastname: Shehaj
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Amicucci
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D012809:Colon, Sigmoid; D004238:Diverticulitis / Q000601:surgery*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010102:Oxygen Inhalation Therapy; D019990:Perioperative Care; D011446:Prospective Studies; D012307:Risk Factors; D013530:Surgical Wound Infection / Q000517:prevention & control*; D016896:Treatment Outcome