title: The life cycle of the 26S proteasome: from birth, through regulation and function, and onto its death.
abstract: The 26S proteasome is a large, ∼2.5 MDa, multi-catalytic ATP-dependent protease complex that serves as the degrading arm of the ubiquitin system, which is the major pathway for regulated degradation of cytosolic, nuclear and membrane proteins in all eukaryotic organisms.
authors.affiliation: Technion Integrated Cancer Center (TICC), The Rappaport Faculty of Medicine and Research Institute, Haifa, Israel.
authors.forename: Ido
authors.initials: I
authors.lastname: Livneh
authors.affiliation: Technion Integrated Cancer Center (TICC), The Rappaport Faculty of Medicine and Research Institute, Haifa, Israel.
authors.forename: Victoria
authors.initials: V
authors.lastname: Cohen-Kaplan
authors.affiliation: Technion Integrated Cancer Center (TICC), The Rappaport Faculty of Medicine and Research Institute, Haifa, Israel.
authors.forename: Chen
authors.initials: C
authors.lastname: Cohen-Rosenzweig
authors.affiliation: Technion Integrated Cancer Center (TICC), The Rappaport Faculty of Medicine and Research Institute, Haifa, Israel.
authors.forename: Noa
authors.initials: N
authors.lastname: Avni
authors.affiliation: Technion Integrated Cancer Center (TICC), The Rappaport Faculty of Medicine and Research Institute, Haifa, Israel.
authors.forename: Aaron
authors.initials: A
authors.lastname: Ciechanover
mesh_terms: D000818:Animals; D006801:Humans; D046988:Proteasome Endopeptidase Complex / Q000737:chemistry / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D059748:Proteolysis; D013379:Substrate Specificity
chemical_list: D046988:Proteasome Endopeptidase Complex; C061553:ATP dependent 26S protease