title: Marine Peptides as Anticancer Agents: A Remedy to Mankind by Nature.
abstract: BACKGROUND
  In the search of bioactive molecules, nature has always been an important source and most of the drugs in clinic are either natural products or derived from natural products. The ocean has played significant role as thousands of molecules and their metabolites with different types of biological activity such as antimicrobial, anti-inflammatory, anti-malarial, antioxidant, anti HIV and anticancer activity have been isolated from marine organisms. In particular, marine peptides have attracted much attention due to their high specificity against cancer cell lines that may be attributed to the various unusual amino acid residues and their sequences in the peptide chain. This review aims to identify the various anticancer agents isolated from the marine system and their anticancer potential.
  
  
  METHODS
  We did literature search for the anticancer peptides isolated from the different types of microorganism found in the marine system. Total one eighty eight papers were reviewed concisely and most of the important information from these papers were extracted and kept in the present manuscript.
  
  
  RESULTS
  This review gives details about the isolation, anticancer potential and mechanism of action of the anticancer peptides of the marine origin. Many of these molecules such as aplidine, dolastatin 10, didemnin B, kahalalide F, elisidepsin (PM02734) are in clinical trials for the treatment of various cancers.
  
  
  CONCLUSIONS
  With the interdisciplinary and collaborative research and technical advancements we can search more promising and affordable anticancer drugs in future.
authors.affiliation: Department of Chemistry, University of Delhi, Delhi-110007, India.
authors.forename: Beena
authors.initials: B
authors.lastname: Negi
authors.affiliation: Department of Chemistry, University of Delhi, Delhi-110007, India.
authors.forename: Deepak
authors.initials: D
authors.lastname: Kumar
authors.affiliation: Department of Chemistry, University of Delhi, P.O. Box: 110007, New Delhi, India.
authors.forename: Diwan S
authors.initials: DS
authors.lastname: Rawat
mesh_terms: D039903:Actinobacteria / Q000737:chemistry; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D059001:Aquatic Organisms / Q000737:chemistry*; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000458:Cyanobacteria / Q000737:chemistry; D005658:Fungi / Q000737:chemistry; D006801:Humans; D008974:Mollusca / Q000737:chemistry; D009369:Neoplasms / Q000188:drug therapy*; D010455:Peptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry; D013302:Streptomyces / Q000737:chemistry; D014561:Urochordata / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products; D010455:Peptides; D010456:Peptides, Cyclic
keywords: Marine peptides; anti-cancer agents; apratoxin; dolastatin 10; elisidepsin; kahalalide F; milnamide B