title: The Feasibility of Using Metacognitive Strategy Training to Improve Cognitive Performance and Neural Connectivity in Women with Chemotherapy-Induced Cognitive Impairment.
abstract: OBJECTIVE
  To evaluate the feasibility and preliminary effect of metacognitive strategy training (MCST) on cognitive performance and on neural connectivity in the frontoparietal network in women with chemotherapy-induced cognitive impairment (CICI) following treatment for breast cancer.
  
  
  METHODS
  A single-group pre/post study was conducted. After completing the baseline assessment battery and neuroimaging, the participants completed a 12-session MCST intervention. Following the completion of the intervention, the subjects completed the same assessment battery and neuroimaging as was completed at baseline within 4 weeks after the intervention. The key inclusion/exclusion criteria for this study were: completed chemotherapy for treatment of breast cancer, no other neurological or psychiatric diagnoses, self-reported CICI, and no contraindications to the use of MRI.
  
  
  RESULTS
  MCST had a small-to-large positive effect on all primary (cognitive) and secondary (quality of life and psychosocial) behavioral outcome measures (r = -0.12 to -0.88). There was also a positive change in functional connectivity in a frontoparietal cognitive control network connection in 6 of the 10 subjects, which was correlated to changes in the behavioral measures.
  
  
  CONCLUSIONS
  This study found that MCST was associated with a positive effect on cognitive performance and neural connectivity in women with CICI following treatment for breast cancer.
authors.affiliation: Department of Occupational Therapy, School of Health Professions, University of Missouri, Columbia, Mo., USA.
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Wolf
authors.forename: Meghan
authors.initials: M
authors.lastname: Doherty
authors.forename: Dorina
authors.initials: D
authors.lastname: Kallogjeri
authors.forename: Rebecca S
authors.initials: RS
authors.lastname: Coalson
authors.forename: Joyce
authors.initials: J
authors.lastname: Nicklaus
authors.forename: Cynthia X
authors.initials: CX
authors.lastname: Ma
authors.forename: Bradley L
authors.initials: BL
authors.lastname: Schlaggar
authors.forename: Jay
authors.initials: J
authors.lastname: Piccirillo
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects; D001943:Breast Neoplasms / Q000188:drug therapy*; D060825:Cognitive Dysfunction / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000628:therapy*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D000067489:Metacognition; D008875:Middle Aged; D059906:Neuroimaging; D011788:Quality of Life; D012919:Social Behavior; D011795:Surveys and Questionnaires
chemical_list: D000970:Antineoplastic Agents