title: Validation of the 6-Month GRACE Score in Predicting 1-Year Mortality of Patients With Acute Coronary Syndrome Admitted to the Arabian Gulf Hospitals.
abstract: Acute coronary syndromes (ACS) are the most common cardiovascular diseases and are associated with a significant risk of mortality and morbidity. The Global Registry of Acute Coronary Events (GRACE) risk score postdischarge is a widely used ACS prediction model for risk of mortality (low, intermediate, and high); however, it has not yet been validated in patients from the Arabian Gulf. This prospective multicenter study (second Gulf Registry of Acute Coronary Events) provides detailed information of the GRACE risk score postdischarge in patients from the Arabian Gulf. Its prognostic utility was validated at 1-year follow-up in over 5000 patients with ACS from 65 hospitals in 6 Arabian Gulf countries (Bahrain, Saudi Arabia, Qatar, Oman, United Arab Emirates, and Yemen). Overall, the goodness of fit (Hosmer and Lemeshow statistic P value = .826), calibration, and discrimination (area under the receiver operating characteristic curve = 0.695; 95% confidence interval: 0.668-0.722) were good. The GRACE risk score postdischarge can be used to stratify 1 year mortality risk in the Arabian Gulf population; it does not require further calibration and has a good discriminatory ability.
authors.affiliation: 1 Department of Public Health, College of Health Sciences, Qatar University, Doha, Qatar.
authors.forename: Lukman
authors.initials: L
authors.lastname: Thalib
authors.affiliation: 2 Research School of Population Health, Australian National University, Canberra, ACT, Australia.
authors.forename: Luis
authors.initials: L
authors.lastname: Furuya-Kanamori
authors.affiliation: 3 Department of Cardiac Sciences, King Fahad Cardiac Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Khalid F
authors.initials: KF
authors.lastname: AlHabib
authors.affiliation: 3 Department of Cardiac Sciences, King Fahad Cardiac Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Hussam F
authors.initials: HF
authors.lastname: Alfaleh
authors.affiliation: 3 Department of Cardiac Sciences, King Fahad Cardiac Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Mostafa Q
authors.initials: MQ
authors.lastname: AlShamiri
authors.affiliation: 4 Mohammed Bin Khalifa Cardiac Center, Manama, Bahrain.
authors.forename: Haitham
authors.initials: H
authors.lastname: Amin
authors.affiliation: 5 Department of Cardiology, Hamad Medical Corporation, Doha, Qatar.
authors.forename: Jassim
authors.initials: J
authors.lastname: Al Suwaidi
authors.affiliation: 6 Department of Cardiology, Royal Hospital, Muscat, Oman.
authors.forename: Kadhim
authors.initials: K
authors.lastname: Sulaiman
authors.affiliation: 7 Heart and Vascular Institute, Cleveland Clinic, Abu Dhabi, United Arab Emirates.
authors.forename: Wael
authors.initials: W
authors.lastname: Almahmeed
authors.affiliation: 8 College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates.|9 Institute of Cardiac Sciences, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates.|10 Institute for Clinical Research and Health Policy Studies, Tufts University School of Medicine, Boston, MA, USA.
authors.forename: Alawi A
authors.initials: AA
authors.lastname: Alsheikh-Ali
authors.affiliation: 11 Department of Cardiology, Sana'a University, Sana'a, Yemen.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Al-Motarreb
authors.affiliation: 2 Research School of Population Health, Australian National University, Canberra, ACT, Australia.|12 College of Medicine, Qatar University, Doha, Qatar.|13 School of Agricultural, Environmental and Computing Sciences, University of Southern Queensland, Toowoomba, Queensland, Australia.
authors.forename: Suhail A R
authors.initials: SA
authors.lastname: Doi
mesh_terms: D054058:Acute Coronary Syndrome / Q000175:diagnosis* / Q000401:mortality* / Q000628:therapy; D000368:Aged; D003661:Decision Support Techniques; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008877:Middle East / Q000453:epidemiology; D010343:Patient Admission; D010351:Patient Discharge; D011237:Predictive Value of Tests; D015995:Prevalence; D011379:Prognosis; D011446:Prospective Studies; D012042:Registries; D015203:Reproducibility of Results; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors
keywords: GRACE risk score; acute coronary syndrome; mortality; postdischarge; validation