title: The function of SH2B3 (LNK) in the kidney.
abstract: Recent evidence indicates the adaptor protein SH2B3 has a major role in the progression of renal diseases. SH2B3 is highly expressed by hematopoietic cells and regulates cytokine signaling, inducing cell-specific effects. Additionally, its expression in other cell types suggests that SH2B3 may have a more extensive role within the kidney. Ex vivo studies have determined targets of SH2B3 cell-specific signaling, while in vivo studies have observed the SH2B3 overall affects in the progression of renal diseases. This mini-review covers the function of SH2B3-expressing cell types that contribute to renal pathologies and their regulation by SH2B3.
authors.affiliation: Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin gblass@mcw.edu.
authors.forename: Gregory
authors.identifier: 0000-0002-4549-4281
authors.initials: G
authors.lastname: Blass
authors.affiliation: Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.
authors.forename: David L
authors.initials: DL
authors.lastname: Mattson
authors.affiliation: Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.
authors.forename: Alexander
authors.identifier: 0000-0002-5190-8356
authors.initials: A
authors.lastname: Staruschenko
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D007668:Kidney / Q000378:metabolism*; D007674:Kidney Diseases / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D047908:Intracellular Signaling Peptides and Proteins; D011506:Proteins; C490778:SH2B3 protein, human
keywords: LNK; SH2B adaptor protein 3; hematopoietic; hypertension; lymphocyte