title: Relation between Resting State Front-Parietal EEG Coherence and Executive Function in Parkinson's Disease.
abstract: Objective. To assess the relation between executive dysfunction (ED) in Parkinson's disease (PD) and resting state functional connectivity evaluated using electroencephalography (EEG) coherence. Methods. Sixty-eight nondemented sporadic PD patients were assessed using the Behavioural Assessment of the Dysexecutive Syndrome (BADS) to evaluate executive function. EEG coherence in the left frontoparietal electrode pair (F3-P3) and the right frontoparietal electrode pair (F4-P4) was analyzed in the alpha and theta range. The BADS scores were compared across the coherence groups, and the multiple logistic regression analysis was performed to assess the contribution of confounders. Results. The standardized BADS score was significantly lower in the low F3-P3 coherence group in the alpha range (Mann-Whitney U test, p = 0.032), though there was no difference between F4-P4 coherence group in the alpha range, F3-P3, and F4-P4 coherence groups in the theta range and the standardized BADS score. The multiple logistic regression analysis revealed the significant relation between the F3-P3 coherence group in alpha range and age-controlled standardized BADS score (p = 0.039, 95% CI = 1.002-1.062). Conclusion. The decrease in resting state functional connectivity between the frontal and parietal cortices especially in the left side is related to ED in PD.
authors.affiliation: Division of Neurology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kami-cho, Itabashi-ku, Tokyo 173-8610, Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Teramoto
authors.affiliation: Division of Neurology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kami-cho, Itabashi-ku, Tokyo 173-8610, Japan.
authors.forename: Akihiko
authors.identifier: 0000-0001-6869-9805
authors.initials: A
authors.lastname: Morita
authors.affiliation: Division of Neurology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kami-cho, Itabashi-ku, Tokyo 173-8610, Japan.
authors.forename: Satoko
authors.identifier: 0000-0001-8661-6700
authors.initials: S
authors.lastname: Ninomiya
authors.affiliation: Division of Neurology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kami-cho, Itabashi-ku, Tokyo 173-8610, Japan.
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Akimoto
authors.affiliation: Division of Neurology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kami-cho, Itabashi-ku, Tokyo 173-8610, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shiota
authors.affiliation: Division of Neurology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kami-cho, Itabashi-ku, Tokyo 173-8610, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kamei
mesh_terms: D000368:Aged; D015986:Confounding Factors, Epidemiologic; D004566:Electrodes; D004569:Electroencephalography / Q000379:methods*; D056344:Executive Function; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010296:Parietal Lobe / Q000503:physiopathology*; D010300:Parkinson Disease / Q000503:physiopathology*; D012146:Rest