title: Carfilzomib/pomalidomide single-agent or in combination with other agents for the management of relapsed/refractory multiple myeloma: a meta-analysis of 37 trials.
abstract: OBJECTIVE
  The use of carfilzomib/pomalidomide single-agent or in combination with other agents in patients with refractory/relapsed multiple myeloma (RRMM) was not clearly clarified in clinical practice. We sought to compile the available clinical reports to better understand the efficacy and safety of carfilzomib (CFZ) and pomalidomide (POM).
  
  
  RESULTS
  Based on our research criteria, we identified 37 prospective studies that evaluated 1160 patients. Analysis of subgroup differences between carfilzomib single-agent and CFZ/DEX dual combination showed significantly(P < 0.001, I2 = 96.3%), suggesting the overall response rate (ORR) of 66% attained from CFZ/DEX dual combination seemed to be higher than that of 28% from carfilzomib single-agent. And, the same trend favoring CFZ/DEX dual combination was found in ≥VGPR and CBR analysis. The ORR of 31% attained from POM/DEX dual combination was superior to that of 19% from pomalidomide single-agent(P < 0.001, I2 = 94.4%). And, the same trend favoring POM/DEX dual combination was found in ≥VGPR and CBR analysis. However, the ORR of 83% attained from POM/BOR/DEX triplet combination was superior to that of 31% from POM/DEX dual combination(P < 0.001, I2 = 99.1%). And, the same trend favoring POM/BOR/DEX triplet combination was found in ≥VGPR analysis.
  
  
  METHODS
  We searched published reports including carfilzomib and (or) pomalidomide therapy for RRMM who had received bortezomib and (or) lenalidomide.
  
  
  CONCLUSIONS
  Pomalidomide/Carfilzomib plus dexamethasone seemed to attain a superior response rate compared with pomalidomide/carfilzomib single-agent. Furthermore, the combination of pomalidomide, bortezomib and dexamethasone resulted in a much higher response rate compared with pomalidomide plus dexamethasone regimen. These results needed more validation in future trials.
authors.affiliation: Internal Medicine, Guang Dong Women and Children Hospital, Guang Zhou, China.
authors.forename: Yandun
authors.initials: Y
authors.lastname: Zou
authors.affiliation: Department of I.C.U, Weifang People's Hospital, Weifang, China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Pediatrics, Weifang People's Hospital, Weifang, China.
authors.forename: Haiying
authors.initials: H
authors.lastname: Yu
authors.affiliation: Internal Medicine, Guang Dong Women and Children Hospital, Guang Zhou, China.
authors.forename: Chunling
authors.initials: C
authors.lastname: Hu
authors.affiliation: Internal Medicine, Guang Dong Women and Children Hospital, Guang Zhou, China.
authors.forename: Limei
authors.initials: L
authors.lastname: Fan
authors.affiliation: Department of Hematology, Weifang People's Hospital, Weifang, China.
authors.forename: Xuehong
authors.initials: X
authors.lastname: Ran
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D019468:Disease Management; D019008:Drug Resistance, Neoplasm; D006801:Humans; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000473:pathology; D009842:Oligopeptides / Q000008:administration & dosage; D011446:Prospective Studies; D016879:Salvage Therapy; D013792:Thalidomide / Q000008:administration & dosage / Q000031:analogs & derivatives
chemical_list: D009842:Oligopeptides; D013792:Thalidomide; C524865:carfilzomib; C467566:pomalidomide
keywords: bortezomib; carfilzomib; lenalidomide; multiple myeloma; pomalidomide