title: "Lupoid hepatitis" in SLE patients and mice with experimental lupus.
abstract: The unusual subset of patients with severe hepatitis, hypergammaglobulinemia, arthritis, and LE cells in the blood reported by Henry Kunkel and others suggested to these investigators that "lupoid" hepatitis might share pathogenic mechanisms with SLE. More than half a century later, the etiology of autoimmune hepatitis remains unclear. The occurrence of autoimmune hepatitis in a small fraction (about 3%) of SLE patients in our lupus cohort and in two mouse models of SLE supports their conclusion that lupoid hepatitis may be share pathogenic mechanisms with SLE. The development of autoimmune hepatitis in mice with pristane-induced lupus provides an opportunity to further explore the potential link between these two autoimmune disorders.
authors.affiliation: Division of Rheumatology & Clinical Immunology, University of Florida, Gainesville, FL 32610. United States.
authors.forename: Stepan
authors.initials: S
authors.lastname: Shumyak
authors.affiliation: Department of Pathology, Immunology, & Laboratory Medicine, University of Florida, Gainesville, FL 32610. United States.
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Yang
authors.affiliation: Division of Rheumatology & Clinical Immunology, University of Florida, Gainesville, FL 32610. United States.
authors.forename: Shuhong
authors.initials: S
authors.lastname: Han
authors.affiliation: Division of Rheumatology & Clinical Immunology, University of Florida, Gainesville, FL 32610. United States.
authors.forename: Haoyang
authors.initials: H
authors.lastname: Zhuang
authors.affiliation: Division of Rheumatology & Clinical Immunology, University of Florida, Gainesville, FL 32610. United States. Electronic address: whreeves@ufl.edu.
authors.forename: Westley H
authors.initials: WH
authors.lastname: Reeves
mesh_terms: D000199:Actins / Q000276:immunology; D000328:Adult; D000368:Aged; D000818:Animals; D001323:Autoantibodies / Q000097:blood; D004195:Disease Models, Animal; D005260:Female; D019693:Hepatitis, Autoimmune / Q000097:blood / Q000276:immunology / Q000473:pathology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008099:Liver / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000139:chemically induced / Q000276:immunology / Q000473:pathology; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008875:Middle Aged; D009130:Muscle, Smooth / Q000276:immunology; D012712:Serum Globulins / Q000032:analysis; D013729:Terpenes; D055815:Young Adult
chemical_list: D000199:Actins; D001323:Autoantibodies; D007074:Immunoglobulin G; D012712:Serum Globulins; D013729:Terpenes; C009042:pristane