title: Sleep and Lipid Profile During Transition from Childhood to Adolescence.
abstract: To assess the longitudinal effects of sleep duration and quality on lipid profiles during the transition from childhood to early adolescence, over a 4-year-period.
  
  
  
  A cohort study of children born in 1998 examined at 8 years of age (SD, 0.3; n = 105) and 12 years of age (SD, 0.5; n = 190). Sleep duration, wake after sleep onset, sleep efficiency, and weekend catch-up sleep were measured with actigraphs for 7 (8 years of age) and 8 (12 years of age) nights. Fasting serum samples were collected at 12 years of age. Covariates included age, pubertal development, socioeconomic status, body mass index, and physical activity.
  
  
  
  In girls, shorter sleep duration at 8 and 12 years of age was associated with lower high-density lipoprotein-cholesterol and higher triglycerides at 12 years of age. Poorer sleep quality at 8 years of age and longer weekend catch-up sleep at 12 years of age was associated with higher triglycerides at 12 years of age. From 8 to 12 years of age, improvement in sleep quality associated with higher total cholesterol, and a decrease in sleep duration with lower lipid levels. In boys, longer sleep duration at 8 years of age, and a larger decrease in sleep duration from 8 to 12 years of age was associated with higher levels of triglycerides at 12 years of age.
  
  
  
  Poorer sleep during transition to early adolescence is associated with an atherogenic lipid profile in early adolescent girls, and such effects are less prominent in boys. Poor sleep may have long-term associations with health, which are not mitigated by the amount of physical activity.
authors.affiliation: Institute of Behavioral Sciences, University of Helsinki, Finland. Electronic address: liisa.kuula-paavola@helsinki.fi.
authors.forename: Liisa
authors.initials: L
authors.lastname: Kuula
authors.affiliation: Institute of Behavioral Sciences, University of Helsinki, Finland.
authors.forename: Anu-Katriina
authors.initials: AK
authors.lastname: Pesonen
authors.affiliation: Children's Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland; Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland; Department of Obstetrics and Gynecology, MRC Oulu, Oulu University Hospital, University of Oulu, Oulu, Finland.
authors.forename: Eero
authors.initials: E
authors.lastname: Kajantie
authors.affiliation: Institute of Behavioral Sciences, University of Helsinki, Finland; Helsinki Collegium for Advanced Studies, University of Helsinki, Helsinki, Finland; Folkhälsan Research Centre, Helsinki, Finland.
authors.forename: Jari
authors.initials: J
authors.lastname: Lahti
authors.affiliation: Children's Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
authors.forename: Sture
authors.initials: S
authors.lastname: Andersson
authors.affiliation: University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland; Center for Life Course Epidemiology and Systems Medicine, University of Oulu, Oulu, Finland.
authors.forename: Timo
authors.initials: T
authors.lastname: Strandberg
authors.affiliation: Institute of Behavioral Sciences, University of Helsinki, Finland.
authors.forename: Katri
authors.initials: K
authors.lastname: Räikkönen
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D002784:Cholesterol / Q000097:blood*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D012890:Sleep; D014280:Triglycerides / Q000097:blood*
chemical_list: D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol
keywords: actigraph; cholesterol; lipid profile; sleep duration; sleep quality