title: Effect of Intravenous Glucose Tolerance Test on Bone Turnover Markers in Adults with Normal Glucose Tolerance.
abstract: BACKGROUND It is well known that enteral nutrients result in acute suppression of bone turnover markers (BTMs), and incretin hormones are believed to play a significant role in this physiological skeletal response. However, there is limited research exploring the impact of parenteral nutrients on BTMs. Our aim was to assess the influence of intravenous glucose on BTMs in adults with normal glucose tolerance (NGT). MATERIAL AND METHODS We conducted 1-h intravenous glucose tolerance test (IVGTT) in 24 subjects with NGT. Blood samples were collected before and 5, 10, 15, 20, 30, 60 min after administration of glucose, then serum levels of bone formation marker procollagen type I N-terminal propeptide (P1NP) and resorption marker C-terminal cross-linking telopeptides of collagen type I (CTX) were measured. RESULTS During IVGTT, the fasting CTX level fell gradually and reached a nadir of 80.4% of the basal value at 60 min. Conversely, the fasting P1NP level decreased mildly and reached a nadir of 90.6% of the basal value at 15 min, then gradually increased and reached 96.6% at 60 min. The CTX-to-P1NP ratio increased slightly and reached a peak of 104.3% of the basal value at 10 min, then fell gradually and reached a nadir of 83% at 60 min. CONCLUSIONS Our study indicates that intravenous glucose results in an acute suppression of BTMs in the absence of incretin hormones. The mechanism responsible for this needs further investigation.
authors.affiliation: Department of Endocrinology, Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China (mainland).
authors.forename: Shou-Kui
authors.initials: SK
authors.lastname: Xiang
authors.affiliation: Department of Endocrinology, Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China (mainland).
authors.forename: Jing-Bo
authors.initials: JB
authors.lastname: Wan
authors.affiliation: Department of Endocrinology, Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China (mainland).
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Jiang
authors.affiliation: Department of Clinical Laboratory Medicine, Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China (mainland).
authors.forename: Yong-Hua
authors.initials: YH
authors.lastname: Zhu
authors.affiliation: Department of Clinical Laboratory Medicine, Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China (mainland).
authors.forename: Jin-Hong
authors.initials: JH
authors.lastname: Ma
authors.affiliation: Department of Endocrinology, Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China (mainland).
authors.forename: Fei
authors.initials: F
authors.lastname: Hua
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D016723:Bone Remodeling / Q000502:physiology*; D024042:Collagen Type I / Q000097:blood; D005260:Female; D005947:Glucose / Q000378:metabolism; D005951:Glucose Tolerance Test / Q000009:adverse effects / Q000379:methods*; D064368:Healthy Volunteers; D006801:Humans; D054795:Incretins / Q000378:metabolism; D008297:Male; D015675:Osteocalcin / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D011347:Procollagen / Q000097:blood
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D024042:Collagen Type I; D054795:Incretins; D010446:Peptide Fragments; D011347:Procollagen; C047202:procollagen Type I N-terminal peptide; D015675:Osteocalcin; D005947:Glucose