title: Partial prediction of postpartum Graves' thyrotoxicosis by sensitive bioassay for thyroid-stimulating antibody measured in early pregnancy.
abstract: Graves' disease often occurs after delivery. However, it has been difficult to predict who will develop Graves' hyperthyroidism. We attempted to predict postpartum onset of Graves' disease by measuring anti-TSH receptor antibodies (TRAb) and thyroid-stimulating antibodies (TSAb) in early pregnancy. TRAb was measured by a third generation assay and TSAb was measured by a newly developed sensitive bioassay. In 690 early pregnant women, 2 showed borderline TRAb positive reactions. However, none of them developed Graves' disease after delivery. Thirty-eight of 690 pregnant women were positive for anti-thyroid peroxidase antibodies (TPOAb) and 4 were positive for TSAb. Two of these 4 women developed postpartum Graves' hyperthyroidism. These findings indicate that the third generation TRAb assay was not useful, but that the sensitive TSAb bioassay was moderately useful for predicting the postpartum onset of Graves' hyperthyroidism.
authors.affiliation: Department of Internal Medicine, Kuma Hospital, Kobe, Japan.
authors.forename: Akane
authors.initials: A
authors.lastname: Ide
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Amino
authors.forename: Eijun
authors.initials: E
authors.lastname: Nishihara
authors.forename: Takumi
authors.initials: T
authors.lastname: Kudo
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Ito
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Kimura
authors.forename: Nobuya
authors.initials: N
authors.lastname: Tatsumi
authors.forename: Mineo
authors.initials: M
authors.lastname: Yamazaki
authors.forename: Akira
authors.initials: A
authors.lastname: Miyauchi
mesh_terms: D001323:Autoantibodies / Q000032:analysis / Q000097:blood; D001681:Biological Assay / Q000379:methods; D003940:Diagnostic Techniques, Endocrine; D005260:Female; D006111:Graves Disease / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D018828:Immunoglobulins, Thyroid-Stimulating / Q000032:analysis* / Q000097:blood; D049590:Postpartum Period / Q000097:blood; D011237:Predictive Value of Tests; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood; D011296:Prenatal Diagnosis / Q000379:methods*; D011379:Prognosis; D011644:Puerperal Disorders / Q000097:blood / Q000175:diagnosis*; D012680:Sensitivity and Specificity; D013971:Thyrotoxicosis / Q000097:blood / Q000175:diagnosis*
chemical_list: D001323:Autoantibodies; D018828:Immunoglobulins, Thyroid-Stimulating; C056626:thyroid microsomal antibodies; C094372:thyrotropin-binding inhibitory immunoglobulin