title: Prognostic value of decreased FOXP1 protein expression in various tumors: a systematic review and meta-analysis.
abstract: The prognostic value of forkhead box protein P1 (FOXP1) protein expression in tumors remains controversial. Therefore, we conducted a systematic review and meta-analysis, searching the PubMed, Embase and Web of Science databases to identify eligible studies. In total, we analyzed 22 articles that examined 9 tumor types and included 2468 patients. Overall, decreased expression of FOXP1 protein was associated with favorable overall survival (OS) in lymphoma patients (HR = 0.38, 95%CI: 0.30-0.48, p < 0.001). In patients with solid tumors, decreased FOXP1 expression correlated with unfavorable OS (HR = 1.82, 95%CI: 1.18-2.83, p = 0.007). However, when FOXP1 protein expression was nuclear, decreased expression was also associated with favorable OS (HR = 0.53, 95%CI: 0.32-0.86, p = 0.011). Furthermore, decreased FOXP1 expression resulted in the best OS in patients with mucosa-associated lymphoid tissue (MALT) lymphomas (HR = 0.26, 95%CI: 0.11-0.59, p = 0.001), but the worst OS was observed in non-small cell lung cancer (NSCLC) patients (HR = 3.11, 95%CI: 1.87-5.17, p < 0.001). In addition, decreased FOXP1 expression was significantly correlated with an unfavorable relapse-free survival (RFS) in breast cancer patients (HR = 1.93, 95%CI: 1.33-2.80, p = 0.001).
authors.affiliation: Department of Geriatrics, Respiratory Medicine, Xiangya Hospital of Central South University, Changsha, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Xiao
authors.affiliation: Department of Geriatrics, Respiratory Medicine, Xiangya Hospital of Central South University, Changsha, China.
authors.forename: Bixiu
authors.initials: B
authors.lastname: He
authors.affiliation: Department of Geriatrics, Respiratory Medicine, Xiangya Hospital of Central South University, Changsha, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zou
authors.affiliation: Department of Respiratory Medicine, Xiangya Hospital of Central South University, Changsha, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Geriatrics, Respiratory Medicine, Xiangya Hospital of Central South University, Changsha, China.
authors.forename: Xiaoxiao
authors.initials: X
authors.lastname: Lu
authors.affiliation: Department of Geriatrics, Respiratory Medicine, Xiangya Hospital of Central South University, Changsha, China.
authors.forename: Mingxuan
authors.initials: M
authors.lastname: Xie
authors.affiliation: Department of Geriatrics, Respiratory Medicine, Xiangya Hospital of Central South University, Changsha, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Biochemistry and Biology, University of South China, Hengyang, China.
authors.forename: Shuya
authors.initials: S
authors.lastname: He
authors.affiliation: Laboratory of Cancer Experimental Therapy, Atlanta Research &Educational Foundation (151F), Atlanta VA Medical Center, Decatur, GA, USA.
authors.forename: Shaojin
authors.initials: S
authors.lastname: You
authors.affiliation: Department of Geriatrics, Respiratory Medicine, Xiangya Hospital of Central South University, Changsha, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Chen
mesh_terms: D018572:Disease-Free Survival; D051858:Forkhead Transcription Factors / Q000378:metabolism*; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009369:Neoplasms / Q000378:metabolism*; D011379:Prognosis; D017594:Publication Bias; D012097:Repressor Proteins / Q000378:metabolism*
chemical_list: C486626:FOXP1 protein, human; D051858:Forkhead Transcription Factors; D012097:Repressor Proteins