title: Geometric control and modeling of genome reprogramming.
abstract: Cell geometry is tightly coupled to gene expression patterns within the tissue microenvironment. This perspective synthesizes evidence that the 3D organization of chromosomes is a critical intermediate for geometric control of genomic programs. Using a combination of experiments and modeling we outline approaches to decipher the mechano-genomic code that governs cellular homeostasis and reprogramming.
authors.affiliation: a Department of Electrical Engineering & Computer Science , and Institute for Data, Systems and Society, MIT , Cambridge , MA , USA.
authors.forename: Caroline
authors.initials: C
authors.lastname: Uhler
authors.affiliation: b Mechanobiology Institute National University of Singapore , Singapore.|c FIRC Institute of Molecular Oncology (IFOM) , Milan , Italy.
authors.forename: G V
authors.initials: GV
authors.lastname: Shivashankar
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D002451:Cell Compartmentation / Q000235:genetics; D019070:Cell Lineage / Q000235:genetics; D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism / Q000648:ultrastructure; D065150:Cellular Reprogramming; D002843:Chromatin / Q000737:chemistry / Q000378:metabolism; D005057:Eukaryotic Cells / Q000378:metabolism* / Q000648:ultrastructure; D005786:Gene Expression Regulation; D016678:Genome; D006801:Humans; D009928:Organ Specificity; D059008:Time-Lapse Imaging; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin; D014157:Transcription Factors
keywords: cell geometry; chromosome organization; gene expression; nuclear morphology; sphere packing models