title: Acute toxicity of dichloroacetonitrile (DCAN), a typical nitrogenous disinfection by-product (N-DBP), on zebrafish (Danio rerio).
abstract: Dichloroacetonitrile (DCAN) is a typical nitrogenous disinfection by-product (N-DBP) and its toxicity on aquatic animals is investigated for the first time. The present study was designed to investigate the potential adverse effects of DCAN on zebrafish. DCAN could induce developmental toxicity to zebrafish embryos. A significant decrease in hatchability and an increase in malformation and mortality occurred when DCAN concentration was above 100µg/L. Heart function alteration and neuronal function disturbance occurred at concentration higher than 500 and 100µg/L, respectively. Further, DCAN was easily accumulated in adult zebrafish. The rank order of declining bioconcentration factor (BCF) was liver (1240-1670)> gill (1210-1430)> muscle (644-877). DCAN caused acute metabolism damage to adult zebrafish especially at 8 days exposure, at which time the "Integrated Biomarker Response" (IBR) index value reached 798 at 1mg/L DCAN dose. Acute DNA damage was induced to adult zebrafish by DCAN even at 10µg/L dose.
authors.affiliation: Ministry of Education Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes, Hohai University, Nanjing 210098, PR China; College of Environment, Hohai University, Nanjing 210098, PR China. Electronic address: hit_lintao@163.com.
authors.forename: Tao
authors.initials: T
authors.lastname: Lin
authors.affiliation: Ministry of Education Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes, Hohai University, Nanjing 210098, PR China; College of Environment, Hohai University, Nanjing 210098, PR China.
authors.forename: Dongju
authors.initials: D
authors.lastname: Zhou
authors.affiliation: Suzhou City Water Company Limited, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Dong
authors.affiliation: Suzhou City Water Company Limited, China.
authors.forename: Fuchun
authors.initials: F
authors.lastname: Jiang
authors.affiliation: College of Environment, Hohai University, Nanjing 210098, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
mesh_terms: D000097:Acetonitriles / Q000378:metabolism / Q000633:toxicity*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D015415:Biomarkers / Q000378:metabolism; D004249:DNA Damage / Q000187:drug effects; D004202:Disinfectants / Q000633:toxicity*; D004203:Disinfection; D004625:Embryo, Nonmammalian / Q000187:drug effects*; D047108:Embryonic Development / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D013550:Swimming; D014874:Water Pollutants, Chemical / Q000633:toxicity*; D018508:Water Purification; D015027:Zebrafish
chemical_list: D000097:Acetonitriles; D015415:Biomarkers; D004202:Disinfectants; D014874:Water Pollutants, Chemical; C051716:dichloroacetonitrile
keywords: DCAN; Nitrogenous disinfection by-product; Toxicity; Zebrafish