title: Rhabdomyolysis associated with single-dose intravenous esomeprazole administration: A case report.
abstract: BACKGROUND
  Proton pump inhibitors are usually safe, although serious adverse effects can occur. We report the first case of rhabdomyolysis associated with single-dose intravenous esomeprozole administration.
  
  
  METHODS
  A 45-year-old Korean male visited our emergency room because of persistent lower chest discomfort that started 10 hours before. He had been diagnosed with diabetes and coronary heart disease, but discontinued oral hypoglycemic agents 1 month earlier. He continued to take medications for coronary heart disease. There was no abnormality on an electrocardiogram or in cardiac enzymes. Initial laboratory findings did not show abnormalities for muscle enzymes. Esomeprozole 40 mg was administrated intravenously for the control of his ambiguous chest discomfort. Then, 12 hours later, he complained of abrupt severe right buttock pain. An area of tender muscle swelling 8 cm in diameter was seen on his right buttock area. Creatine kinase and lactate dehydrogenase were elevated to 40,538 and 1326 U/L, respectively. A bone scan using 20 mCi of Tc-hydroxymethylene diphosphonate was compatible with rhabdomyolysis.
  
  
  RESULTS
  His muscular symptoms, signs, and laboratory findings improved markedly with conservative management, including hydration and urine alkalinization. He is being followed in the outpatient department with no evidence of recurrence.
  
  
  CONCLUSIONS
  We should keep in mind that single-dose intravenous administration of esomeprazole can induce rhabdomyolysis.
authors.affiliation: Department of Internal Medicine, Gyeongsang National University Hospital, Jinju Department of Internal Medicine, Changwon Gyeongsang National University Hospital, Changwon Department of Internal Medicine, Gyeongsang National University School of Medicine, Internal Medicine Institute of Health Science, Gyeongsang National University, Jinju, South Korea.
authors.forename: Dae-Hong
authors.initials: DH
authors.lastname: Jeon
authors.forename: Yire
authors.initials: Y
authors.lastname: Kim
authors.forename: Min Jeong
authors.initials: MJ
authors.lastname: Kim
authors.forename: Hyun Seop
authors.initials: HS
authors.lastname: Cho
authors.forename: Eun Jin
authors.initials: EJ
authors.lastname: Bae
authors.forename: Se-Ho
authors.initials: SH
authors.lastname: Chang
authors.forename: Dong Jun
authors.initials: DJ
authors.lastname: Park
mesh_terms: D000328:Adult; D002637:Chest Pain / Q000188:drug therapy*; D000072700:Conservative Treatment; D064098:Esomeprazole / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D054328:Proton Pump Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy
chemical_list: D054328:Proton Pump Inhibitors; D064098:Esomeprazole