title: Capillary-induced Homogenization of Matrix in Paper: A Powerful Approach for the Quantification of Active Pharmaceutical Ingredients Using Mass Spectrometry Imaging.
abstract: Herein we present a novel approach for the quantification of active pharmaceutical ingredients (APIs) using mass spectrometry imaging. This strategy uses a filter paper previously "eluted" with a MALDI matrix solution as a support for analyte application. Samples are submitted to mass spectrometry imaging (MSI) and quantification through characteristic fingerprints is ultimately performed. Results for the content of rosuvastatin from a known formulation are comparable to those obtained with a validated HPLC method.
authors.affiliation: INNOVARE Biomarkers Laboratory, School of Pharmaceutical Sciences, University of Campinas, Campinas, 13083-877 SP, Brazil.
authors.forename: Maico
authors.initials: M
authors.lastname: de Menezes
authors.affiliation: INNOVARE Biomarkers Laboratory, School of Pharmaceutical Sciences, University of Campinas, Campinas, 13083-877 SP, Brazil.
authors.forename: Diogo Noin
authors.initials: DN
authors.lastname: de Oliveira
authors.affiliation: INNOVARE Biomarkers Laboratory, School of Pharmaceutical Sciences, University of Campinas, Campinas, 13083-877 SP, Brazil.
authors.forename: Rodrigo Ramos
authors.initials: RR
authors.lastname: Catharino