title: The Management of Locally Invasive Primary Thyroid Paraganglioma: A Case Report and Review of the Literature.
abstract: Paragangliomas (PG) are very rare neuroendocrine tumours, arising from neural crest derived paraganglia of the autonomic nervous system. Primary thyroid paraganglioma (PTPG) is a rare site of PG and only 45 cases have been previously reported. The preoperative diagnosis of PTPGs presents a challenge as the clinical, cytological and histological features overlap with more common primary thyroid cancers. A 55 year old male was found to have significant enlargement of the left lobe of his thyroid. Following lobectomy, the thyroid lobe showed unencapsulated tumour which was positive for synaptophysin, CD56 and S100 (sustentacular cells). Post-operative imaging demonstrated incomplete resection. There was no post-operative radiotherapy and monitoring was by 6-12 monthly MRI. 48 months after his surgery he is alive and well with no evidence of disease progression. The diagnosis of PTPG was only made postoperatively, and although rare should be considered in the differential diagnosis of a hypervascular thyroid nodule.
authors.affiliation: The Royal London Hospital, London, UK. lalin.navaratne@doctors.org.uk.
authors.forename: L
authors.identifier: http://orcid.org/0000-0002-1939-0825
authors.initials: L
authors.lastname: Navaratne
authors.affiliation: Frimley Park Hospital, Camberley, UK.
authors.forename: R G
authors.initials: RG
authors.lastname: Mathew
authors.affiliation: Frimley Park Hospital, Camberley, UK.
authors.forename: G
authors.initials: G
authors.lastname: Kousparos
authors.affiliation: Frimley Park Hospital, Camberley, UK.
authors.forename: A
authors.initials: A
authors.lastname: McCombe
mesh_terms: D006801:Humans; D008297:Male; D008875:Middle Aged; D010236:Paraganglioma, Extra-Adrenal / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D013965:Thyroidectomy
keywords: CD56; Synaptophysin; Thyroid paraganglioma