title: CATCHR, HOPS and CORVET tethering complexes share a similar architecture.
abstract: We show here that the Saccharomyces cerevisiae GARP complex and the Cog1-4 subcomplex of the COG complex, both members of the complexes associated with tethering containing helical rods (CATCHR) family of multisubunit tethering complexes, share the same subunit organization. We also show that HOPS, a tethering complex acting in the endolysosomal pathway, shares a similar architecture, thus suggesting that multisubunit tethering complexes use related structural frameworks.
authors.affiliation: Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Hui-Ting
authors.identifier: 0000-0002-8693-8571
authors.initials: HT
authors.lastname: Chou
authors.affiliation: Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Danijela
authors.initials: D
authors.lastname: Dukovski
authors.affiliation: Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Melissa G
authors.initials: MG
authors.lastname: Chambers
authors.affiliation: Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: Karin M
authors.initials: KM
authors.lastname: Reinisch
authors.affiliation: Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Walz
mesh_terms: D033942:Adaptor Proteins, Vesicular Transport / Q000648:ultrastructure; D026901:Membrane Transport Proteins / Q000648:ultrastructure; D008854:Microscopy, Electron; D008958:Models, Molecular; D046912:Multiprotein Complexes / Q000648:ultrastructure; D020836:Protein Structure, Quaternary; D021122:Protein Subunits / Q000737:chemistry; D012441:Saccharomyces cerevisiae / Q000648:ultrastructure*; D029701:Saccharomyces cerevisiae Proteins / Q000648:ultrastructure; D033921:Vesicular Transport Proteins / Q000648:ultrastructure
chemical_list: D033942:Adaptor Proteins, Vesicular Transport; C112749:COG2 protein, S cerevisiae; C401396:COG3 protein, S cerevisiae; C468122:COG4 protein, S cerevisiae; C503913:Cog1 protein, S cerevisiae; D026901:Membrane Transport Proteins; D046912:Multiprotein Complexes; D021122:Protein Subunits; D029701:Saccharomyces cerevisiae Proteins; D033921:Vesicular Transport Proteins