title: Fluctuation in Serum Sodium Levels Related to Ipragliflozin Administration in a Patient with Diabetic Nephropathy and Sequela of Traumatic Brain Injury.
abstract: A 46-year-old diabetic man underwent the removal of a hematoma caused by traumatic brain injury. After surgery, severe hyponatremia occurred. The subsequent administration of NaCl and fludrocortisone improved his laboratory findings. The patient was transferred to our hospital, and his insulin therapy was replaced by teneligliptin. One week later, ipragliflozin treatment was initiated and induced an immediate increase in the serum sodium levels. NaCl and fludrocortisone were therefore discontinued. However, hyponatremia recurred after ipragliflozin withdrawal due to a urinary tract infection. NaCl and fludrocortisone were initiated again, and the laboratory data improved. We herein report a case of serum sodium fluctuation related to ipragliflozin administration.
authors.affiliation: Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Japan.
authors.forename: Hideo
authors.initials: H
authors.lastname: Okonogi
authors.forename: Mikio
authors.initials: M
authors.lastname: Harada
authors.forename: Hironobu
authors.initials: H
authors.lastname: Sato
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Tokoro
authors.forename: Issei
authors.initials: I
authors.lastname: Nakayama
authors.forename: Nobuo
authors.initials: N
authors.lastname: Tsuboi
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Miyazaki
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kawamura
authors.forename: Makoto
authors.initials: M
authors.lastname: Ogura
authors.forename: Takashi
authors.initials: T
authors.lastname: Yokoo
mesh_terms: D000070642:Brain Injuries, Traumatic / Q000150:complications*; D003920:Diabetes Mellitus / Q000188:drug therapy*; D003928:Diabetic Nephropathies / Q000150:complications*; D005438:Fludrocortisone / Q000627:therapeutic use; D005960:Glucosides / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007010:Hyponatremia / Q000188:drug therapy / Q000209:etiology; D007328:Insulin; D008297:Male; D008875:Middle Aged; D012964:Sodium / Q000097:blood* / Q000378:metabolism; D013876:Thiophenes / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D005960:Glucosides; D007328:Insulin; D013876:Thiophenes; C572941:ipragliflozin; D012964:Sodium; D005438:Fludrocortisone