title: [THE OBESITY IMPACT ON INFLAMMATORY MARKERS IN PATIENTS WITH ARTERIAL HYPERTENSION].
abstract: The aim of the study was to determine the concentrations of inflammatory markers C-reactive protein (C-RP) and cytokines - IL-1β, IL-4 in patients with arterial hypertension (AH) and obesity. The study involved 64 patients with hypertension, who were divided into 2 groups. The first (main group) consisted of 39 patients with arterial hypertension II degree and obesity 1 st. The second group was performed by 25 patients diagnosed with hypertension II degree without obesity. The study of serum cytokines was carried out by ELISA using the company›s «Ukrmedservis» sets, Ukraine, and for the C-RP - set, company «DRG International Inc.» (USA) following instructions. Obesity was assessed by body mass index and waist to hip ratio. The study found that hypertension with obesity is characterized by a more pronounced increasing in the C-RP and IL-1 β and reducing in anti-inflammatory IL-4, in comparison with the control group. And this is the evidence of a significant activation of inflammatory processes in such cohort of the patients. Thus immunoinflammatory disorders are essential in the development of hypertension in combination with obesity. A direct link is detected between obesity and the severity of inflammation in patients with hypertension.
authors.affiliation: Kharkov National Medical University, Ukraine.
authors.forename: A
authors.initials: A
authors.lastname: Shelest
authors.affiliation: Kharkov National Medical University, Ukraine.
authors.forename: J
authors.initials: J
authors.lastname: Kovaleva
authors.affiliation: Kharkov National Medical University, Ukraine.
authors.forename: B
authors.initials: B
authors.lastname: Shelest
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications / Q000276:immunology; D007249:Inflammation / Q000097:blood / Q000276:immunology; D053583:Interleukin-1beta / Q000097:blood*; D015847:Interleukin-4 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000150:complications / Q000276:immunology
chemical_list: D015415:Biomarkers; D053583:Interleukin-1beta; D015847:Interleukin-4; D002097:C-Reactive Protein