title: Unique Presentation of Orf Virus Infection in a Thermal-Burn Patient After Receiving an Autologous Skin Graft.
abstract: We describe a burn patient who developed skin lesions on her skin-graft harvest and skin-graft recipient (burn) sites. Orf virus infection was confirmed by a combination of diagnostic assays, including molecular tests, immunohistochemical analysis, pathologic analysis, and electron microscopy. DNA sequence analysis grouped this orf virus isolate among isolates from India. Although no definitive source of infection was determined from this case, this is the first reported case of orf virus infection in a skin graft harvest. Skin graft recipients with exposures to animals may be at risk for this viral infection.
authors.affiliation: Poxvirus and Rabies Branch Epidemic Intelligence Service, Atlanta, Georgia.
authors.forename: Christopher H
authors.initials: CH
authors.lastname: Hsu
authors.affiliation: Department of Dermatology, Bo Ali Sina Hospital, Hamedan.
authors.forename: Ghasem Rahmatpour
authors.initials: GR
authors.lastname: Rokni
authors.affiliation: Razi Dermatology Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Nessa
authors.initials: N
authors.lastname: Aghazadeh
authors.affiliation: Department of Dermatology, New York University Medical Center, New York.
authors.forename: Nooshin
authors.initials: N
authors.lastname: Brinster
authors.affiliation: Poxvirus and Rabies Branch.
authors.forename: Yu
authors.initials: Y
authors.lastname: Li
authors.affiliation: Infectious Diseases Pathology Branch, Centers for Disease Control and Prevention.
authors.forename: Atis
authors.initials: A
authors.lastname: Muehlenbachs
authors.affiliation: Infectious Diseases Pathology Branch, Centers for Disease Control and Prevention.
authors.forename: Cynthia S
authors.initials: CS
authors.lastname: Goldsmith
authors.affiliation: Poxvirus and Rabies Branch.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Poxvirus and Rabies Branch.
authors.forename: Brett
authors.initials: B
authors.lastname: Petersen
authors.affiliation: Poxvirus and Rabies Branch.
authors.forename: Andrea M
authors.initials: AM
authors.lastname: McCollum
authors.affiliation: Poxvirus and Rabies Branch.
authors.forename: Mary G
authors.initials: MG
authors.lastname: Reynolds
mesh_terms: D002056:Burns / Q000473:pathology / Q000821:virology*; D002675:Child, Preschool; D004279:DNA, Viral / Q000235:genetics; D004474:Ecthyma, Contagious / Q000473:pathology / Q000821:virology*; D005260:Female; D006801:Humans; D009923:Orf virus / Q000235:genetics / Q000302:isolation & purification*; D017422:Sequence Analysis, DNA / Q000379:methods; D012867:Skin / Q000473:pathology / Q000821:virology*; D016038:Skin Transplantation / Q000009:adverse effects*
chemical_list: D004279:DNA, Viral
keywords: Orf virus; Parapoxvirus; skin graft; thermal burn