title: Simultaneous Analysis of 2D Echo Views for Left Atrial Segmentation and Disease Detection.
abstract: We propose a joint information approach for automatic analysis of 2D echocardiography (echo) data. The approach combines a priori images, their segmentations and patient diagnostic information within a unified framework to determine various clinical parameters, such as cardiac chamber volumes, and cardiac disease labels. The main idea behind the approach is to employ joint Independent Component Analysis of both echo image intensity information and corresponding segmentation labels to generate models that jointly describe the image and label space of echo patients on multiple apical views, instead of independently. These models are then both used for segmentation and volume estimation of cardiac chambers such as the left atrium and for detecting pathological abnormalities such as mitral regurgitation. We validate the approach on a large cohort of echoes obtained from 6,993 studies. We report performance of the proposed approach in estimation of the left-atrium volume and detection of mitral-regurgitation severity. A correlation coefficient of 0.87 was achieved for volume estimation of the left atrium when compared to the clinical report. Moreover, we classified patients that suffer from moderate or severe mitral regurgitation with an average accuracy of 82%.
authors.forename: Gregory
authors.initials: G
authors.lastname: Allan
authors.forename: Saman
authors.initials: S
authors.lastname: Nouranian
authors.forename: Teresa
authors.initials: T
authors.lastname: Tsang
authors.forename: Alexander
authors.initials: A
authors.lastname: Seitel
authors.forename: Maryam
authors.initials: M
authors.lastname: Mirian
authors.forename: John
authors.initials: J
authors.lastname: Jue
authors.forename: Dale
authors.initials: D
authors.lastname: Hawley
authors.forename: Sarah
authors.initials: S
authors.lastname: Fleming
authors.forename: Ken
authors.initials: K
authors.lastname: Gin
authors.forename: Jody
authors.initials: J
authors.lastname: Swift
authors.forename: Robert
authors.initials: R
authors.lastname: Rohling
authors.forename: Purang
authors.initials: P
authors.lastname: Abolmaesumi
mesh_terms: D004452:Echocardiography; D006325:Heart Atria; D006331:Heart Diseases / Q000000981:diagnostic imaging*; D006801:Humans; D008944:Mitral Valve Insufficiency