title: Atherogenic index of plasma may be strong predictor of subclinical atherosclerosis in patients with Behçet disease.
abstract: OBJECTIVE
  Behcet's disease (BD) is a systemic vasculitis characterized by cardiovascular complications. Early diagnosis of these complications can reduce morbidity and mortality. Carotid artery intima-media thickness (cIMT) and the logarithmic value of triglyceride to high density lipoprotein ratio (atherogenic index of plasma, AIP) are good markers of atherosclerosis. The purpose of this study was to investigate whether AIP is a predictive marker of subclinical atherosclerosis in BD patients.
  
  
  METHODS
  A total of 84 BD patients (60 male, 24 female) and 84 healthy control individuals (58 male, 26 female) were included in this study. cIMT measurements were made, and AIP values were calculated.
  
  
  RESULTS
  cIMT (p < 0.001) and AIP (p < 0.001) values of the BD patients were higher than those of the control group. A strong independent relationship was found between the AIP value and cIMT (β = 0.232, p = 0.018). In the subgroup analysis, the cIMT and AIP values of male BD patients were higher than those of female BD patients.
  
  
  CONCLUSIONS
  Increased AIP and cIMT values can be a good marker for subclinical atherosclerosis in BD patients, especially in male BD patients.
authors.affiliation: Recep Tayyip Erdogan University, Rize, Turkey. erkancure@yahoo.com.
authors.forename: E
authors.initials: E
authors.lastname: Cure
authors.affiliation: Necmettin Erbakan University, Konya, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Icli
authors.affiliation: Eskisehir Military Hospital, Eskisehir, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Ugur Uslu
authors.affiliation: Malatya State Hospital, Malatya, Turkey.
authors.forename: R
authors.initials: R
authors.lastname: Aydoğan Baykara
authors.affiliation: Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors.forename: D
authors.initials: D
authors.lastname: Sakiz
authors.affiliation: Necmettin Erbakan University, Konya, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Ozucan
authors.affiliation: Dogubeyazit Docent Dr Yasar Eryilmaz State Hospital, Agri, Turkey.
authors.forename: F
authors.initials: F
authors.lastname: Yavuz
authors.affiliation: Necmettin Erbakan University, Konya, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Arslan
authors.affiliation: Recep Tayyip Erdogan University, Rize, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Cumhur Cure
authors.affiliation: Malatya State Hospital, Malatya, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Kucuk
mesh_terms: D000328:Adult; D058070:Asymptomatic Diseases / Q000453:epidemiology*; D050197:Atherosclerosis / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D001528:Behcet Syndrome / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D015415:Biomarkers / Q000097:blood; D059168:Carotid Intima-Media Thickness / Q000706:statistics & numerical data*; D016022:Case-Control Studies; D015984:Causality; D015897:Comorbidity; D005260:Female; D006801:Humans; D015994:Incidence; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D011379:Prognosis; D015203:Reproducibility of Results; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D014280:Triglycerides / Q000097:blood*; D014421:Turkey / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D008075:Lipoproteins, HDL; D014280:Triglycerides
keywords: Atherogenic index of plasma; Behçet’s disease; Carotid artery intima–media thickness; Subclinical atherosclerosis