title: NALP3-Inflammasome-Related Gene Polymorphisms in Patients with Prehypertension and Coronary Atherosclerosis.
abstract: Objectives. Prehypertension is an early stage of hypertension that is characterized by inflammatory factors. Inflammation also plays an essential role in the development of coronary atherosclerosis (CAS). The present study evaluated the NALP3-inflammasome and its related genes, NLRP3, NOD2, and CARD8, using SNP linkage and gene haplotypes in prehypertensive patients. Methods. A total of 576 patients with prehypertension and suspected coronary heart disease (CHD) were enrolled. According to coronary angiography, patients were divided into two groups: arterial stenosis <50% of the diameter (control) and arterial stenosis >50% of the diameter (case). Fifteen polymorphisms in the NOD2, NLRP3, and CARD8 genes were analyzed, and serum levels of C-reactive protein (CRP) were measured. Results. When comparing allele frequencies, none of these 15 SNPs in NOD2, CARD8, and NLPR3 genes showed a significant difference using multiple logistic regression. However, the CTACATAA (p = 0.0064) and CCACATAG (p = 0.0126) haplotypes of the NOD2 gene SNPs were significantly different between cases and controls. Conclusions. Although our study excludes a significant association of selected SNPs in these genes with CHD in prehypertension patients, this work suggests that the CTACATAA and CCACATAG haplotypes were associated with CHD in the NOD2 locus. This work suggests that the CTACATAA and CCACATAG haplotypes were associated with CHD in prehypertension patients in the NOD2 locus.
authors.affiliation: Cardiovascular Research Institute and Department of Cardiology, General Hospital of Shenyang Military Region, 83 Wenhua Road, Shenyang, Liaoning 110840, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Cardiovascular Research Institute and Department of Cardiology, General Hospital of Shenyang Military Region, 83 Wenhua Road, Shenyang, Liaoning 110840, China; Jinzhou Medical University, Jinzhou 121000, China.
authors.forename: Chonghuai
authors.initials: C
authors.lastname: Gu
authors.affiliation: Cardiovascular Research Institute and Department of Cardiology, General Hospital of Shenyang Military Region, 83 Wenhua Road, Shenyang, Liaoning 110840, China.
authors.forename: Chenghui
authors.initials: C
authors.lastname: Yan
authors.affiliation: Cardiovascular Research Institute and Department of Cardiology, General Hospital of Shenyang Military Region, 83 Wenhua Road, Shenyang, Liaoning 110840, China.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Cardiovascular Research Institute and Department of Cardiology, General Hospital of Shenyang Military Region, 83 Wenhua Road, Shenyang, Liaoning 110840, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.affiliation: Cardiovascular Research Institute and Department of Cardiology, General Hospital of Shenyang Military Region, 83 Wenhua Road, Shenyang, Liaoning 110840, China; Jinzhou Medical University, Jinzhou 121000, China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: Cardiovascular Research Institute and Department of Cardiology, General Hospital of Shenyang Military Region, 83 Wenhua Road, Shenyang, Liaoning 110840, China; Jinzhou Medical University, Jinzhou 121000, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Ren
authors.affiliation: Cardiovascular Research Institute and Department of Cardiology, General Hospital of Shenyang Military Region, 83 Wenhua Road, Shenyang, Liaoning 110840, China; Jinzhou Medical University, Jinzhou 121000, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Cardiovascular Research Institute and Department of Cardiology, General Hospital of Shenyang Military Region, 83 Wenhua Road, Shenyang, Liaoning 110840, China; Jinzhou Medical University, Jinzhou 121000, China.
authors.forename: Junyin
authors.initials: J
authors.lastname: Peng
authors.affiliation: Chongqing Institute of Hypertension, Daping Hospital, Third Military Medical University, Chongqing 404100, China.
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: Cardiovascular Research Institute and Department of Cardiology, General Hospital of Shenyang Military Region, 83 Wenhua Road, Shenyang, Liaoning 110840, China.
authors.forename: Yaling
authors.identifier: 0000-0002-5541-8776
authors.initials: Y
authors.lastname: Han
mesh_terms: D002097:C-Reactive Protein / Q000235:genetics; D053468:CARD Signaling Adaptor Proteins / Q000235:genetics; D003324:Coronary Artery Disease / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D058847:Inflammasomes / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics; D053473:Nod2 Signaling Adaptor Protein / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D058246:Prehypertension / Q000235:genetics*
chemical_list: D053468:CARD Signaling Adaptor Proteins; C455623:CARD8 protein, human; D058847:Inflammasomes; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C453881:NLRP3 protein, human; C429018:NOD2 protein, human; D009363:Neoplasm Proteins; D053473:Nod2 Signaling Adaptor Protein; D002097:C-Reactive Protein