title: Precision treatment with sirolimus in a case of activated phosphoinositide 3-kinase δ syndrome.
authors.affiliation: University Hospital Southampton NHS Foundation Trust, Southampton, UK. Electronic address: will.rae@nhs.net.
authors.forename: William
authors.initials: W
authors.lastname: Rae
authors.affiliation: University Hospital Southampton NHS Foundation Trust, Southampton, UK; Faculty of Medicine, University of Southampton, Southampton, UK; Southampton NIHR Wellcome Trust Clinical Research Facility, Southampton, UK.
authors.forename: Kesava A
authors.initials: KA
authors.lastname: Ramakrishnan
authors.affiliation: Faculty of Medicine, University of Southampton, Southampton, UK; NIHR Cancer Research UK Experimental Cancer Medicine Centre, Southampton, UK.
authors.forename: Yifang
authors.initials: Y
authors.lastname: Gao
authors.affiliation: University Hospital Southampton NHS Foundation Trust, Southampton, UK.
authors.forename: Margaret
authors.initials: M
authors.lastname: Ashton-Key
authors.affiliation: Department of Human Genetics and Genomic Medicine, Faculty of Medicine, University of Southampton, Southampton, UK.
authors.forename: Reuben J
authors.initials: RJ
authors.lastname: Pengelly
authors.affiliation: Department of Paediatric Infectious Diseases and Immunology, Southampton Children's Hospital, Southampton, UK.
authors.forename: Sanjay V
authors.initials: SV
authors.lastname: Patel
authors.affiliation: Department of Human Genetics and Genomic Medicine, Faculty of Medicine, University of Southampton, Southampton, UK.
authors.forename: Sarah
authors.initials: S
authors.lastname: Ennis
authors.affiliation: University Hospital Southampton NHS Foundation Trust, Southampton, UK; Faculty of Medicine, University of Southampton, Southampton, UK; NIHR Cancer Research UK Experimental Cancer Medicine Centre, Southampton, UK.
authors.forename: Anthony P
authors.initials: AP
authors.lastname: Williams
authors.affiliation: University Hospital Southampton NHS Foundation Trust, Southampton, UK; Faculty of Medicine, University of Southampton, Southampton, UK; Southampton NIHR Wellcome Trust Clinical Research Facility, Southampton, UK.
authors.forename: Saul N
authors.initials: SN
authors.lastname: Faust
mesh_terms: D002675:Child, Preschool; D058534:Class I Phosphatidylinositol 3-Kinases; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000188:drug therapy*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D000081207:Primary Immunodeficiency Diseases; D020123:Sirolimus / Q000627:therapeutic use*
chemical_list: D007166:Immunosuppressive Agents; D058534:Class I Phosphatidylinositol 3-Kinases; D020123:Sirolimus
keywords: Activated phosphoinositide 3-kinase δ syndrome; Autoimmune hemolytic anemia; Sirolimus