title: [HORMONALLY-GENETICALLY DEPENDENT THERAPY, USING VITAMIN K IN PATIENTS, SUFFERING THE ULCER HEMORRHAGE].
abstract: Pathophysiological mechanisms of the vitamin K impact, including those in the gut with ulcerative affection, are studied still insufficiently. Investigations of pharmacogenomics of the vitamin K gives a new approach to therapy in patients, suffering gastro-intestinal hemorrhage. Possibilities of titration of the vitamin K3 (menadione) doses, depending on level of estrogenemia and genetic constitution, concerning genes-candidates ESR1 (rs2234693) and VKORC1 (rs9923231), were studied. There were examined 36 patients, who were treated for the ulcer hemorrhage. The blood serum concentration of estradiol was investigated in accordance to method of solid phase enzyme immunoassay, the genotyping procedure was performed in accordance to indices of polymerase chain reaction with analysis of the restrictional fragments length. The initial daily dose of menadione have constituted 20 mg. After a genotype determination made (first-second day after admittance to hospital) in patients with normoestrogenemia in genotypes CC/GG, CC/GA, CT/GG, CT/GA a vitaminotherapy was prolonged in daily dose of 20 mg, and in a conditionally-pathological variant of genotype the dose of vitamin K was enhanced up to 30 mg. Determination of hormones and the patients' genetic constitution makes possible to apply a personified approach for the vitamin K3 application in the ulcerative hemorrhage.
authors.forename: I D
authors.initials: ID
authors.lastname: Duzhyi
authors.forename: S V
authors.initials: SV
authors.lastname: Kharchenko
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use*; D054796:Drug Dosage Calculations; D004381:Duodenal Ulcer / Q000097:blood / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D004958:Estradiol / Q000097:blood; D047628:Estrogen Receptor alpha / Q000097:blood / Q000235:genetics*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000097:blood / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D015870:Gene Expression; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D057285:Precision Medicine; D013276:Stomach Ulcer / Q000097:blood / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D014812:Vitamin K / Q000627:therapeutic use*; D064417:Vitamin K Epoxide Reductases / Q000097:blood / Q000235:genetics*
chemical_list: D000925:Anticoagulants; C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; D014812:Vitamin K; D004958:Estradiol; C578523:VKORC1 protein, human; D064417:Vitamin K Epoxide Reductases