title: [Association of GCKR gene polymorphisms and type 2 diabetes among ethnic Uygurs].
abstract: OBJECTIVE
  To assess the association of glucokinase regulator protein (GCKR) gene polymorphisms and type 2 diabetes (T2D) among ethnic Uygurs from Xinjiang, China.
  
  
  METHODS
  One thousand and six T2D patients and 1004 healthy controls were recruited. The rs780094 genotype of the GCKR gene was determined with a Sequenom Mass ARRAY system.
  
  
  RESULTS
  The distribution of GCKR rs780094 AA, AG and GG genotypes were not statistically different between the two groups (P>0.05). After adjusting confounding factors, an association of rs780094 with T2D was observed in an additive and dominant model (OR=1.181, 95%CI: 1.021-1.366, P=0.025; OR=1.296, 95%CI: 1.043-1.610, P=0.019). The total cholesterol level was higher in AA carriers than GG and GA carriers (P<0.05).
  
  
  CONCLUSIONS
  The AA genotype of the GCKR rs780094 polymorphism may increase the risk of T2D among ethnic Uygurs from Xinjiang.
authors.affiliation: Xinjiang Key Laboratory of Metabolic Disease, Clinical Medical Research Institute, Department of Endocrinology, Department of Health Management and Health Check, Department of Laboratory Medicine, Department of Infection Control, First Affiliated Hospital, Department of Maternal, Child and Adolescent Health, School of Public Health, Xinjiang Medical University, Urumqi, Xinjiang 830054, China. Email: yaohua01@sina.com.
authors.forename: Qi
authors.initials: Q
authors.lastname: Ma
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Hua
authors.initials: H
authors.lastname: Yao
authors.forename: Jun
authors.initials: J
authors.lastname: Zhu
authors.forename: Shuxia
authors.initials: S
authors.lastname: Wang
authors.forename: Xhaoxia
authors.initials: X
authors.lastname: Zhang
authors.forename: Tingting
authors.initials: T
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Ma
authors.forename: Yinxia
authors.initials: Y
authors.lastname: Su
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Wang
authors.forename: Lili
authors.initials: L
authors.lastname: Ding
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D002681:China / Q000208:ethnology; D002784:Cholesterol / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000209:etiology / Q000235:genetics*; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D011110:Polymorphism, Genetic
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C485100:GCKR protein, human; D002784:Cholesterol