title: Association Between a Polymorphism (rs2071214) in Baculoviral IAP Repeat Containing 5 Gene (BIRC5) and Ischemic Stroke in Korean Population.
abstract: OBJECTIVE
  To investigate whether baculoviral inhibitor of apoptosis (IAP) repeat containing 5 gene (BIRC5) polymorphisms are associated with the development and clinical phenotypes of ischemic stroke in Korea population.
  
  
  METHODS
  We enrolled 121 ischemic stroke patients and 291 control subjects. Ischemic stroke patients were divided into subgroups according to the scores of National Institutes of Health Stroke Survey (<6 or ≥6) and Modified Barthel Index (<60 or ≥60). Single nucleotide polymorphisms (SNPs) of BIRC5 (rs3764383 and rs2071214) were selected and genotyped by direct sequencing for all subjects. Multiple logistic regression models (codominant 1 and 2, dominant, recessive, overdominant and log-additive) were used to estimate odds ratios (ORs), 95% confidence intervals (CIs), and p-values.
  
  
  RESULTS
  In analysis of stroke susceptibility, the genotype and allele frequencies of rs3764383 exhibited no difference between the control group and the ischemic stroke group. SNP rs2071214 was associated with ischemic stroke in the codominant (p=0.003), dominant (p=0.002), overdominant (p=0.005), and log-additive (p=0.008) models, respectively. The G allele frequency of rs2071214 was significantly (p=0.009) associated with susceptibility for ischemic stroke (OR, 1.57; 95% CI, 1.12-2.21). However, in the analysis for clinical phenotype, no SNP of the BIRC5 gene was found to be associated with ischemic stroke.
  
  
  CONCLUSIONS
  These results suggest that a missense SNP (rs2071214) of BIRC5 may be associated with the development of ischemic stroke in the Korean population.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Jinmann
authors.initials: J
authors.lastname: Chon
authors.affiliation: Department of Physical Medicine and Rehabilitation, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Hee-Sang
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Department of Physical Medicine and Rehabilitation, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Dong Hwan
authors.initials: DH
authors.lastname: Yun
authors.affiliation: Department of Physical Medicine and Rehabilitation, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Seung Don
authors.identifier: 0000-0003-4513-2560
authors.initials: SD
authors.lastname: Yoo
authors.affiliation: Department of Physical Medicine and Rehabilitation, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Dong Hwan
authors.initials: DH
authors.lastname: Kim
authors.affiliation: Department of Physical Medicine and Rehabilitation, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Seung Ah
authors.identifier: 0000-0002-3426-6259
authors.initials: SA
authors.lastname: Lee
authors.affiliation: Kohwang Medical Research Institute, Kyung Hee University, Seoul, Korea.
authors.forename: Su Kang
authors.initials: SK
authors.lastname: Kim
authors.affiliation: Kohwang Medical Research Institute, Kyung Hee University, Seoul, Korea.
authors.forename: Hae Jeong
authors.initials: HJ
authors.lastname: Park
authors.affiliation: Kohwang Medical Research Institute, Kyung Hee University, Seoul, Korea.
authors.forename: Joo-Ho
authors.initials: JH
authors.lastname: Chung
authors.affiliation: Department of Physical Medicine and Rehabilitation, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Sungjoon
authors.initials: S
authors.lastname: Chung
authors.affiliation: Department of Physical Medicine and Rehabilitation, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Jinah
authors.identifier: 0000-0003-2796-0805
authors.initials: J
authors.lastname: Yeo
keywords: BIRC5 protein; Brain infarction; Single nucleotide polymorphism