title: mRNA methylation by NSUN2 in cell proliferation.
abstract: Methylation is a prevalent post-transcriptional modification that occurs in almost all RNA species. NSUN2, a nucleolar RNA methyltransferase, has been shown to methylate mRNAs encoding factors that control cell division and growth arrest, thereby affecting their stability and/or translation. Here, the author summarizes the recent progress in understanding NSUN2-mediated mRNA methylation and its implications in cell proliferation and senescence. WIREs RNA 2016, 7:838-842. doi: 10.1002/wrna.1380 For further resources related to this article, please visit the WIREs website.
authors.affiliation: Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, PR China. wwg@bjmu.edu.cn.
authors.forename: Wengong
authors.initials: W
authors.lastname: Wang
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000235:genetics*; D006801:Humans; D008745:Methylation; D008780:Methyltransferases / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics*
chemical_list: D012333:RNA, Messenger; D008780:Methyltransferases; C515610:NSUN2 protein, human