title: Slow release of ciprofloxacin from β- cyclodextrin containing drug delivery system through network formation and supramolecular interactions.
abstract: Supramolecular cyclodextrin (CD) hydrogels have occupied an important position in developing the materials for biomedical application. In the present work an attempt has been made to improve the release profile of ciprofloxacin by designing the β- cyclodextrin containing drug delivery system through network formation and supramolecular interactions. The polymer network has been formed by sterculia gum comprising of glucuronic acid and galacturonic acid and carbopol. The polymers have been characterization by cryo-SEMs, FTIR and13C solid state (NMR) and swelling studies. This article also discusses drug release, blood compatibility, mucoadhesion, gel strength and antioxidant properties of the polymers. The release of drug from β-CD containing hydrogels was slower and less as compared to the hydrogels without β-CD. Release of drugs from drug loaded hydrogels occurred through non-Fickian diffusion mechanism and release profile best fitted in Korsmeyer-Peppas model. These hydrogels have been found as haemocompatible, mucoadhesive, and antioxidant in nature. Mucoadhesive nature can further provide the site specific nature to drug delivery system in GIT.
authors.affiliation: Department of Chemistry, Himachal Pradesh University, Shimla, 171005, India. Electronic address: baljitsinghhpu@yahoo.com.
authors.forename: Baljit
authors.initials: B
authors.lastname: Singh
authors.affiliation: Department of Chemistry, Himachal Pradesh University, Shimla, 171005, India.
authors.forename: Abhishek
authors.initials: A
authors.lastname: Dhiman
authors.affiliation: Department of Chemistry, Himachal Pradesh University, Shimla, 171005, India.
authors.lastname: Rajneesh
authors.affiliation: Department of Chemistry, Himachal Pradesh University, Shimla, 171005, India.
authors.forename: Ajay
authors.initials: A
authors.lastname: Kumar
mesh_terms: D000180:Acrylic Resins; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D002939:Ciprofloxacin / Q000494:pharmacology*; D020285:Cryoelectron Microscopy; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems / Q000379:methods*; D065546:Drug Liberation; D006041:Goats; D006801:Humans; D020100:Hydrogels / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000180:Acrylic Resins; D000975:Antioxidants; D003692:Delayed-Action Preparations; D020100:Hydrogels; D047392:beta-Cyclodextrins; C006912:carboxypolymethylene; D002939:Ciprofloxacin; C031215:betadex
keywords: Ciprofloxacin; Drug release; Network formation; Supramolecular interactions; β- cyclodextrin