title: Intraventricular Neurilemmoma (Schwannoma): Shall GFAP Immunostaining Be Regarded as a Histogenetical Tag or as a Mere Histomimetical Trait?
abstract: Neurilemmomas are benign neoplasms presumedly derived from Schwann cells which rarely originate within the central nervous system. Moreover, their intraventricular location has been seldom noticed with less than 30 cases reported worldwide. Here, we add another case study to the record as well as the fifth one in Latin American population. A 16-year-old boy without significant past clinical data debuted with headache and progressive left eye blindness during six months. Neuroimaging scans showed a bulky, multiloculated, intraventricular tumour emerging from the posterior horn of the left lateral ventricle. Microscopically, the lesion put on view the classical schwannian histology: spindle cells arranged in both compact and loosely textured areas. Verocay bodies were not present but vessel hyalinisation, pericellular reticulin, and senescent atypia were observed. The immunoperoxidase reactions were also consistent with neurilemmal differentiation; however, glial fibrillary acidic protein expression was widespread and unexpectedly seen. Traditionally conceived as "nerve sheath tumours" the dual immunophenotype herein demonstrated points to a different histogenetical pathway other than sheer Schwann cell derivation. As previously advised by some authors, neoplastic transformation from a multipotent stem cell may explain the occasional finding of these tumours in unconventional intracranial compartments.
authors.affiliation: Pathology Unit, Neuropathology Service, Mexico General Hospital, Cuauhtémoc, 06726 Mexico City, DF, Mexico.
authors.forename: Miguel Fdo
authors.identifier: 0000-0002-3201-1922
authors.initials: MF
authors.lastname: Salazar
authors.affiliation: Department of Neuropathology, National Institute of Neurology & Neurosurgery "Manuel Velasco Suárez", Tlalpan, 14269 Mexico City, DF, Mexico.
authors.forename: Martha Lilia
authors.initials: ML
authors.lastname: Tena Suck
authors.affiliation: Department of Neuropathology, National Institute of Neurology & Neurosurgery "Manuel Velasco Suárez", Tlalpan, 14269 Mexico City, DF, Mexico.
authors.forename: Daniel
authors.initials: D
authors.lastname: Rembao Bojórquez
authors.affiliation: Department of Neuropathology, National Institute of Neurology & Neurosurgery "Manuel Velasco Suárez", Tlalpan, 14269 Mexico City, DF, Mexico.
authors.forename: Citlaltepetl
authors.initials: C
authors.lastname: Salinas Lara