title: Helicobacter pyloriInfection with Atrophic Gastritis Is an Independent Risk Factor for Advanced Colonic Neoplasm.
abstract: OBJECTIVE
  Helicobacter pyloriis a major risk factor for atrophic gastritis (AG) and gastric cancer. The correlation betweenH. pylori, AG and colorectal neoplasm (CRN) has only been examined in a limited number of studies, and findings have been inconclusive. We aimed to investigate the association betweenH. pyloriinfection status, AG and advanced CRN.
  
  
  METHODS
  This cross-sectional study investigated the relationship between the presence of serum anti-H. pyloriIgG antibodies, AG, and advanced CRN in 6,351 consecutive asymptomatic subjects who underwent a screening colonoscopy.
  
  
  RESULTS
  A total of 316 participants (5.0%) had advanced CRN.H. pyloriseropositivity was 61.3%. In a univariate analysis, the presence ofH. pyloriinfection was associated with advanced CRN (odds ratio [OR], 1.49; 95% confidence interval [CI], 1.17 to 1.91; p=0.001).H. pyloriinfection was associated with an increased risk of advanced CRN after adjusting for clinically relevant confounders (OR, 1.34; 95% CI, 1.04 to 1.72; p=0.023).H. pylori-related AG was significantly associated with the risk of advanced CRN (OR, 1.40; 95% CI, 1.03 to 1.91; p=0.030), whereasH. pyloriinfection without AG was not.
  
  
  CONCLUSIONS
  H. pyloriinfection increased the risk of advanced CRN, especially when it was combined with AG. Strict colonoscopy screening and surveillance may be warranted in those withH. pylori-positive AG.
authors.affiliation: Health Screening and Promotion Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Lee
authors.affiliation: Health Screening and Promotion Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Hye Won
authors.initials: HW
authors.lastname: Park
authors.affiliation: Health Screening and Promotion Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Choi
authors.affiliation: Health Screening and Promotion Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Jong-Soo
authors.initials: JS
authors.lastname: Lee
authors.affiliation: Health Screening and Promotion Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Ja Eun
authors.initials: JE
authors.lastname: Koo
authors.affiliation: Health Screening and Promotion Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Eun Ju
authors.initials: EJ
authors.lastname: Chung
authors.affiliation: Health Screening and Promotion Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Hye-Sook
authors.initials: HS
authors.lastname: Chang
authors.affiliation: Health Screening and Promotion Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Jaewon
authors.initials: J
authors.lastname: Choe
authors.affiliation: Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Dong-Hoon
authors.initials: DH
authors.lastname: Yang
authors.affiliation: Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Seung-Jae
authors.initials: SJ
authors.lastname: Myung
authors.affiliation: Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Hwoon-Yong
authors.initials: HY
authors.lastname: Jung
authors.affiliation: Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Suk-Kyun
authors.initials: SK
authors.lastname: Yang
authors.affiliation: Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Jeong-Sik
authors.initials: JS
authors.lastname: Byeon
mesh_terms: D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000382:microbiology*; D003113:Colonoscopy / Q000379:methods; D003430:Cross-Sectional Studies; D005260:Female; D005757:Gastritis, Atrophic / Q000097:blood / Q000150:complications* / Q000382:microbiology; D016481:Helicobacter Infections / Q000097:blood / Q000382:microbiology; D016480:Helicobacter pylori / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012307:Risk Factors; D018571:Sentinel Surveillance
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G
keywords: Atrophy; Gastritis; Helicobacter pylori; Neoplasms