title: Elevated taurine and glutamate in cerebral juvenile xanthogranuloma on MR spectroscopy.
abstract: MRI in a 2-year-old female presenting afebrile seizures and left blepharoptosis revealed multiple well-marginated round-shaped lesions, isointensity to gray matter on T1- and T2-weighted images with homogenously reduced diffusion and diffuse contrast enhancement. MRS revealed elevation of taurine, choline and glutamate, and reduction of N-acetylaspartate. A brain biopsy confirmed a diagnosis of juvenile xanthogranuloma (JXG). JXG should be considered when MR spectroscopy shows elevated taurine and glutamate, which has only previously been reported in medulloblastomas.
authors.affiliation: Department of Pediatrics, Tokyo Women's Medical University Yachiyo Medical Center, Yachiyo, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Matsubara
authors.affiliation: Department of Radiology, Graduate School and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
authors.forename: Harushi
authors.initials: H
authors.lastname: Mori
authors.affiliation: Department of Pediatrics, Tokyo Women's Medical University Yachiyo Medical Center, Yachiyo, Japan.
authors.forename: Nozomi
authors.initials: N
authors.lastname: Hirai
authors.affiliation: Department of Pediatrics, Tokyo Women's Medical University Yachiyo Medical Center, Yachiyo, Japan.
authors.forename: Kumi
authors.initials: K
authors.lastname: Yasukawa
authors.affiliation: Department of Pediatrics, Tokyo Women's Medical University Yachiyo Medical Center, Yachiyo, Japan.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Honda
authors.affiliation: Department of Pediatrics, Tokyo Women's Medical University Yachiyo Medical Center, Yachiyo, Japan. Electronic address: jtaka@twmu.ac.jp.
authors.forename: Jun-Ichi
authors.initials: JI
authors.lastname: Takanashi
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D018698:Glutamic Acid / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013654:Taurine / Q000378:metabolism*; D014972:Xanthogranuloma, Juvenile / Q000000981:diagnostic imaging* / Q000378:metabolism
chemical_list: D013654:Taurine; D018698:Glutamic Acid
keywords: Glutamate; Juvenile xanthogranuloma; MR spectroscopy; Taurine