title: Neuropsychiatric manifestations of Parkinson's disease.
abstract: OBJECTIVE
  This clinical update review focuses on the classification and description of common neuropsychiatric manifestations in Parkinson's disease (PD).
  
  
  METHODS
  We conducted a systematic search of the literature using Pubmed and selected the most recent and relevant papers for this review.
  
  
  RESULTS
  Neuropsychiatric manifestations in PD are are very frequent and may arise from an abnormal psychopathological response to the disease, neurobiological changes related to the disease itself, complications of treatments or a combination of all of these.
  
  
  CONCLUSIONS
  Neuropsychiatric symptoms may precede the motor clinical presentation of PD. Early recognition is essential.
authors.affiliation: Hospital Universitario Fundación Alcorcón, Universidad Rey Juan Carlos, Madrid, Spain rmolinar@salud.madrid.org.
authors.forename: Rosa M
authors.initials: RM
authors.lastname: Molina Ruiz
authors.affiliation: Head, Movement Disorders Program, Department of Neurology, Royal Melbourne Hospital, Melbourne, VIC, Australia.
authors.forename: Andrew H
authors.initials: AH
authors.lastname: Evans
authors.affiliation: Professor and Clinical Director, Neuropsychiatry Unit, Royal Melbourne Hospital, Melbourne Neuropsychiatry Centre, University of Melbourne & Northwestern Mental Health, Melbourne, VIC, Australia.
authors.forename: Dennis
authors.initials: D
authors.lastname: Velakoulis
authors.affiliation: Clinical Associate Professor, Neuropsychiatry Unit, Royal Melbourne Hospital, Melbourne Neuropsychiatry Centre, University of Melbourne & Northwestern Mental Health, Melbourne, VIC, and; Associate Professor and Deputy Head, Academic Unit of Psychiatry and Addiction Medicine, Australian National University Medical School, Canberra Hospital, Garran, ACT, Australia.
authors.forename: Jeffrey Cl
authors.initials: JC
authors.lastname: Looi
mesh_terms: D006801:Humans; D001523:Mental Disorders / Q000145:classification* / Q000453:epidemiology*; D058027:Neuropsychiatry; D010300:Parkinson Disease / Q000503:physiopathology* / Q000523:psychology*
keywords: Parkinson’s disease; neuropsychiatric manifestations; psychiatry