title: Friend or foe? Targeting microglia in Alzheimer's disease.
abstract: Inflammation is believed to be a component of a number of degenerative brain diseases including Alzheimer's disease. A recent article by Fu and colleagues (2016) demonstrated that the cytokine IL-33 can modulate microglia in an animal model of AD to become better scavengers of beta-amyloid and less pro-inflammatory. The findings have potential therapeutic implications for a number of brain conditions.
authors.affiliation: Department of Neurology, 125 Paterson Street, Suite 6200, New Brunswick, NJ 08901, United States. Electronic address: Suhayl.jalbut@rutgers.edu.
authors.forename: Suhayl
authors.initials: S
authors.lastname: Dhib-Jalbut
mesh_terms: D000544:Alzheimer Disease; D016229:Amyloid beta-Peptides; D000818:Animals; D060825:Cognitive Dysfunction; D004195:Disease Models, Animal; D000067596:Interleukin-33; D017628:Microglia
chemical_list: D016229:Amyloid beta-Peptides; D000067596:Interleukin-33
keywords: Alzheimer’s disease; Amyloid; IL-33; Microglia