title: [The role of mitochondrial permeability transition pore in the occurrence of septic myocardial depression].
abstract: Sepsis is defined as life-threatening organ dysfunction caused by a dys-regulated host response to infection and septic myocardial depression (SMD) is a common complication. Pathogenesis of SMD is complicated and there is lack of specific treatment. Mitochondrial damage is an important pathological basis of SMD, and mitochondrial permeability transition pore (MPTP) plays an important role in maintaining the normal structure and function of the mitochondria. The change of MPTP during sepsis is summarized in this review so as to reveal the significant mechanism of MPTP in the occurrence of SMD.
authors.affiliation: Department of Critical Care Medicine, Tenth People's Hospital of Tongji University, Shanghai 200072, China. Corresponding author: Wang Sheng, Email: wangsheng@tongji.edu.cn.
authors.forename: Shanzi
authors.initials: S
authors.lastname: Jin
authors.forename: Sheng
authors.initials: S
authors.lastname: Wang
mesh_terms: D006321:Heart / Q000503:physiopathology*; D006801:Humans; D008928:Mitochondria / Q000473:pathology*; D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore; D018805:Sepsis / Q000503:physiopathology*
chemical_list: D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore