title: Rat Testis Damage Caused by Lead Sulfide Nanoparticles After Oral Exposure.
abstract: Lead sulfide nanoparticals (PbS NPs) is an important semiconductor material due to its unique physical and chemical properties, but its potential health hazard to reproductive system is not clear. In the current study, we systematically explored the reproductive toxicity of PbS NPs in rats by measuring the body weight and testicular coefficient, testing serum testosterone levels, and studying the sperm survival rate and sperm abnormality rate. Furthermore, in order to study the toxic mechanism we performed lead contents measurements in testis, and investigated the pathology in testis. Our results confirmed that PbS NPs showed high reproductive toxicity due to PbS NPs in rats' testicular tissue by the establishment of PbS NPs chronic exposure model.
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Cao
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
authors.forename: Qingzhao
authors.initials: Q
authors.lastname: Li
authors.forename: Hongliang
authors.initials: H
authors.lastname: Deng
authors.forename: Jian
authors.initials: J
authors.lastname: Shen
authors.forename: Guoying
authors.initials: G
authors.lastname: Zheng
authors.forename: Miao
authors.initials: M
authors.lastname: Sun
mesh_terms: D000284:Administration, Oral; D000818:Animals; D007854:Lead / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism / Q000633:toxicity*; D008297:Male; D053758:Nanoparticles / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013076:Sperm Count; D013094:Spermatozoa / Q000187:drug effects; D013440:Sulfides / Q000008:administration & dosage / Q000633:toxicity*; D013737:Testis / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology
chemical_list: D013440:Sulfides; C018391:lead sulfide; D007854:Lead