title: Discontinuous unilateral involvement of 12 part core biopsies by adenocarcinoma predicts bilateral involvement of subsequent radical prostatectomy.
abstract: At our institution, percent tumor burden in prostate core biopsies is quantified using variations of one of two methods. Measurement by the Aggregate method reports only adenocarcinoma and omits intervening stroma and benign prostatic glands while the Discontinuous method includes the intervening stroma and benign glands between distinct foci of adenocarcinoma. In this study, we selected cases with 12-part core biopsies that were followed by a radical prostatectomy within two years. Interestingly, we found that when adenocarcinoma involved prostate 12-part core biopsies and subsequent resection unilaterally, there is no significant difference in absolute percentage of tumor using either measuring method (P = 0.4). In contrast, when adenocarcinoma involved the biopsies unilaterally and subsequent prostatectomy bilaterally, the two measurement methods had a statistically significant difference in percentage scores (P = 0.002). In the study cohort, other factors including Gleason score (P = 0.88) and total number of adenocarcinoma-involved cores (P = 0.27) did not introduce any significant correlation with bilateral involvement. In this study, we found that biopsies that discontinuously and unilaterally involve half of a prostate are much more likely to involve both lobes than those that are unilateral and present in nodular aggregates.
authors.affiliation: Department of Pathology, University of California San Diego Medical Center and Veterans Affairs Medical Center San Diego, La Jolla, California, US.
authors.forename: Brett Matthew
authors.initials: BM
authors.lastname: Lowenthal
authors.affiliation: Department of Pathology, University of California San Diego Medical Center and Veterans Affairs Medical Center San Diego, La Jolla, California, US.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Liao
authors.affiliation: GenPath Women's Health Bioreference Laboratories, Elmwood Park, New Jersey, US.
authors.forename: Fang
authors.initials: F
authors.lastname: Wen
authors.affiliation: Undergraduate Program, University of California San Diego, La Jolla, California, US.
authors.forename: Nader
authors.initials: N
authors.lastname: Bagherzadeh
authors.affiliation: Department of Pathology, University of California San Diego Medical Center and Veterans Affairs Medical Center San Diego, La Jolla, California, US.
authors.forename: Sepi
authors.initials: S
authors.lastname: Mahooti
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D062005:Biopsy, Large-Core Needle; D006801:Humans; D008297:Male; D009367:Neoplasm Staging / Q000379:methods; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000473:pathology*
keywords: discontinuous foci; prostate cancer; prostate core biopsy; radical prostatectomy