title: Fentanyl in a pectin gel treating breakthrough pain in vertebral compression fracture due to multiple myeloma: A descriptive study of three cases.
abstract: Breakthrough pain (BTP) currently represents a challenge for health professionals dedicated to the treatment of pain. In this descriptive 1-year follow-up study on three patients with BTP from vertebral crush, in the context of multiple myeloma, the authors have observed the great either efficacy or tolerability profile of fentanyl pectin nasal spray. The most relevant findings in this study were better adherence to treatment compared to previously opioids and also great personal satisfaction. Because of common pathophysiological mechanism for noncancerous pain of bone origin, these good results could open the door to investigation of the use of this drug in this patient's group.
authors.affiliation: Department of Anesthesiology, Clinical Care and Pain Medicine, University Donostia Hospital, Donostia-San Sebastián, Spain.
authors.forename: Borja Mugabure
authors.initials: BM
authors.lastname: Bujedo
authors.affiliation: Full Professor of Biomedical Engineering, School of Science and Engineering, Reykjavík University, Reykjavík, Iceland.
authors.forename: Brynjar
authors.initials: B
authors.lastname: Karlsson
mesh_terms: D000368:Aged; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000627:therapeutic use*; D059846:Analgesics, Short-Acting; D059390:Breakthrough Pain / Q000188:drug therapy*; D004337:Drug Carriers / Q000008:administration & dosage*; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage / Q000627:therapeutic use*; D005500:Follow-Up Studies; D050815:Fractures, Compression / Q000188:drug therapy* / Q000209:etiology; D005782:Gels; D006801:Humans; D008297:Male; D009101:Multiple Myeloma / Q000150:complications*; D059085:Nasal Sprays; D010368:Pectins / Q000008:administration & dosage*; D013124:Spinal Injuries / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000701:Analgesics, Opioid; D059846:Analgesics, Short-Acting; D004337:Drug Carriers; D005782:Gels; D059085:Nasal Sprays; D010368:Pectins; D005283:Fentanyl