title: The role of TGF-β1 869 T > C and PPAR γ2 34 C > G polymorphisms, fat mass, and anthropometric characteristics in predicting childhood obesity at birth: A cross-sectional study according the parental characteristics and newborn's risk for child obesity (the newborns obesity's risk) NOR study.
abstract: This study proposed to establish a correlation between the risk score for child obesity and anthropometric, genetic, and bioimpedance characteristics in mothers and newborns, and to assess the discriminant ability for anthropometric parameters to classify over-fatness (defined by bioimpedance body fatness %) in pregnant women.We performed a cross-sectional study on 388 couples (mother and father) and their newborns admitted in a Tertiary Hospital from Romania. The measured parameters for mothers and their newborns were risk percentage for child obesity, anthropometric characteristics (mid-upper arm circumference [MUAC], tricipital skinfold thickness [TST] of mother and newborn), genetic polymorphisms (human peroxisome proliferator-activated receptor γ [PPARγ2] 34 C > G and transforming growth factor-beta 1 [TGF-β1] 869 T > C gene polymorphisms in both mothers and newborns), and mother's bioimpedance characteristics (fat mass [FM] %).The obesity risk score according to standard predictable Northern Finland Birth Cohort equation was in our study 4.07%. We found a monotone positive significant correlation between the newborn's risk of childhood obesity and the mother's TST (P = 0.01), as well as a tendency toward statistical significance concerning correlation with mother's MUAC (P = 0.053), without any correlations with the mothers' bioimpedance parameters and also a positive correlation between the newborn's risk of childhood obesity and the newborn's anthropometrical characteristics like body mass index (BMI), MUAC, and TST (P < 0.001). We observed that the calculated newborn's risk percentage for child obesity was greater for the variant allele of the TGF-β1 869 T > C polymorphism and also for the wild-type C allele of the PPARγ2 34 C > G gene polymorphism. Our study indicated that the best predictors for over-fatness are BMI and MUAC (P = 0.01 < 0.02 and P = 0.019 < 0.02, respectively).
authors.affiliation: Department of Obstetrics and Gynecology, University of Medicine and Pharmacy, Tîrgu Mureş Department of Pediatrics, University of Medicine and Pharmacy, Tîrgu Mureş Department of Medical Informatics and Biostatistics, University of Medicine and Pharmacy, Cluj Napoca Department of Neonatology, University of Medicine and Pharmacy, Tîrgu Mureş Department of Genetics, University of Medicine and Pharmacy, Tîrgu Mureş, Romania.
authors.forename: Claudiu
authors.initials: C
authors.lastname: Mărginean
authors.forename: Cristina Oana
authors.initials: CO
authors.lastname: Mărginean
authors.forename: Mihaela
authors.initials: M
authors.lastname: Iancu
authors.forename: Bela
authors.initials: B
authors.lastname: Szabo
authors.forename: Manuela
authors.initials: M
authors.lastname: Cucerea
authors.forename: Lorena Elena
authors.initials: LE
authors.lastname: Melit
authors.forename: Andrei
authors.initials: A
authors.lastname: Crauciuc
authors.forename: Claudia
authors.initials: C
authors.lastname: Bănescu
mesh_terms: D000273:Adipose Tissue / Q000254:growth & development*; D000328:Adult; D000483:Alleles; D000886:Anthropometry; D001823:Body Composition / Q000235:genetics*; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D063766:Pediatric Obesity / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011237:Predictive Value of Tests; D011247:Pregnancy; D012306:Risk; D012383:Romania; D013223:Statistics as Topic; D053773:Transforming Growth Factor beta1 / Q000235:genetics*
chemical_list: D053773:Transforming Growth Factor beta1