title: Efficacy of tebuconazole embedded in biodegradable poly-3-hydroxybutyrate to inhibit the development of Fusarium moniliforme in soil microecosystems.
abstract: BACKGROUND
  An important line of research is the development of a new generation of formulations with targeted and controlled release of the pesticide, using matrices made from biodegradable materials. In this study, slow-release formulations of the fungicide tebuconazole (TEB) have been prepared by embedding it into the matrix of poly-3-hydroxybutyrate (P3HB) in the form of films, microgranules and pellets.
  
  
  RESULTS
  The average rates of P3HB degradation were determined by the geometry of the formulation, reaching, for 63 days, 0.095-0.116, 0.081-0.083 and 0.030-0.055 mg day-1for films, microgranules and pellets respectively. The fungicidal activity of P3HB/TEB against the plant pathogen Fusarium moniliforme was compared with that of the commercial formulation Raxil Ultra. A pronounced fungicidal effect of the experimental P3HB/TEB formulations was observed in 2-4 weeks after application, and it was retained for 8 weeks, without affecting significantly the development of soil aboriginal microflora.
  
  
  CONCLUSIONS
  TEB release can be regulated by the process employed to fabricate the formulation and the fungicide loading, and the TEB accumulates in the soil gradually, as the polymer is degraded. The experimental forms of TEB embedded in the slowly degraded P3HB can be used as a basis for developing slow-release fungicide formulations. © 2016 Society of Chemical Industry.
authors.affiliation: Institute of Biophysics, Siberian Section, Russian Academy of Sciences, Krasnoyarsk, Russia.
authors.forename: Tatiana G
authors.initials: TG
authors.lastname: Volova
authors.affiliation: Institute of Biophysics, Siberian Section, Russian Academy of Sciences, Krasnoyarsk, Russia.|Siberian Federal University, Krasnoyarsk, Russia.
authors.forename: Svetlana V
authors.initials: SV
authors.lastname: Prudnikova
authors.affiliation: Institute of Biophysics, Siberian Section, Russian Academy of Sciences, Krasnoyarsk, Russia.
authors.forename: Natalia O
authors.initials: NO
authors.lastname: Zhila
authors.affiliation: Institute of Biophysics, Siberian Section, Russian Academy of Sciences, Krasnoyarsk, Russia.
authors.forename: Olga N
authors.initials: ON
authors.lastname: Vinogradova
authors.affiliation: Institute of Biophysics, Siberian Section, Russian Academy of Sciences, Krasnoyarsk, Russia.
authors.forename: Anna A
authors.initials: AA
authors.lastname: Shumilova
authors.affiliation: Institute of Biophysics, Siberian Section, Russian Academy of Sciences, Krasnoyarsk, Russia.
authors.forename: Elena D
authors.initials: ED
authors.lastname: Nikolaeva
authors.affiliation: Institute of Biophysics, Siberian Section, Russian Academy of Sciences, Krasnoyarsk, Russia.
authors.forename: Evgeniy G
authors.initials: EG
authors.lastname: Kiselev
authors.affiliation: Institute of Biophysics, Siberian Section, Russian Academy of Sciences, Krasnoyarsk, Russia.
authors.forename: Ekaterina I
authors.initials: EI
authors.lastname: Shishatskaya
mesh_terms: D004337:Drug Carriers / Q000737:chemistry / Q000378:metabolism; D004339:Drug Compounding; D065546:Drug Liberation; D017753:Ecosystem; D005659:Fungicides, Industrial / Q000737:chemistry / Q000494:pharmacology; D005670:Fusarium / Q000187:drug effects* / Q000254:growth & development*; D006885:Hydroxybutyrates / Q000737:chemistry* / Q000378:metabolism; D011091:Polyesters / Q000737:chemistry* / Q000378:metabolism; D012988:Soil Microbiology; D014230:Triazoles / Q000737:chemistry* / Q000494:pharmacology*; D000094122:Polyhydroxybutyrates
chemical_list: D004337:Drug Carriers; D005659:Fungicides, Industrial; D006885:Hydroxybutyrates; D011091:Polyesters; D014230:Triazoles; C003182:poly-beta-hydroxybutyrate; D000094122:Polyhydroxybutyrates; C087114:tebuconazole
keywords: degradation; embedding; fungicidal effect; poly-3-hydroxybutyrate; tebuconazole; tebuconazole release