title: Inflammaging and Frailty Status Do Not Result in an Increased Extracellular Vesicle Concentration in Circulation.
abstract: In the last decades extracellular vesicles (EVs) have emerged as key players for intercellular communication. In the case of inflammation, several studies have reported that EV levels are increased in circulation during inflammatory episodes. Based on this, we investigated whether aging results in elevated EV number, as a basal proinflammatory status termed "inflammaging" has been described in aged individuals. Moreover, we also hypothesized that frailty and dependence conditions of the elderly could affect EV concentration in plasma. Results showed that inflammaging, frailty or dependence status do not result in EV increase, at least in the total number of EVs in circulation. These results open a new perspective for investigating the role of EVs in human aging and in the inflammaging process.
authors.affiliation: Multiple Sclerosis Unit, Biodonostia Health Research Institute-Donostia University Hospital, San Sebastian 20014, Spain. ainhoa.alberro@biodonostia.org.
authors.forename: Ainhoa
authors.initials: A
authors.lastname: Alberro
authors.affiliation: Multiple Sclerosis Unit, Biodonostia Health Research Institute-Donostia University Hospital, San Sebastian 20014, Spain. matias.saenz@biodonostia.org.|Spanish Network of Multiple Sclerosis, Barcelona 08028, Spain. matias.saenz@biodonostia.org.
authors.forename: Matías
authors.initials: M
authors.lastname: Sáenz-Cuesta
authors.affiliation: Multiple Sclerosis Unit, Biodonostia Health Research Institute-Donostia University Hospital, San Sebastian 20014, Spain. maider.munoz@biodonostia.org.|Spanish Network of Multiple Sclerosis, Barcelona 08028, Spain. maider.munoz@biodonostia.org.
authors.forename: Maider
authors.initials: M
authors.lastname: Muñoz-Culla
authors.affiliation: Primary Care Research Unit-Gipuzkoa, Osakidetza, Biodonostia Health Research Institute, San Sebastian 20014, Spain. maider.mateoabad@osakidetza.eus.
authors.forename: Maider
authors.initials: M
authors.lastname: Mateo-Abad
authors.affiliation: Metabolomics Unit, CIC bioGUNE, CIBERehd, Technology Park of Bizkaia, Derio, Bizkaia 48980, Spain. egonzalez@cicbiogune.es.
authors.forename: Esperanza
authors.initials: E
authors.lastname: Gonzalez
authors.affiliation: Cellular Oncology Group, Biodonostia Health Research Institute, San Sebastian 20014, Spain. estefania.carrasco@biodonostia.org.
authors.forename: Estefania
authors.initials: E
authors.lastname: Carrasco-Garcia
authors.affiliation: Computational Biology and Systems Biomedicine Group, Biodonostia Health Research Institute, San Sebastian 20014, Spain. marcos.arauzo@biodonostia.org.|IKERBASQUE, Basque Foundation for Science, Bilbao 48015, Spain. marcos.arauzo@biodonostia.org.
authors.forename: Marcos J
authors.initials: MJ
authors.lastname: Araúzo-Bravo
authors.affiliation: Cellular Oncology Group, Biodonostia Health Research Institute, San Sebastian 20014, Spain. ander.matheu@biodonostia.org.|IKERBASQUE, Basque Foundation for Science, Bilbao 48015, Spain. ander.matheu@biodonostia.org.
authors.forename: Ander
authors.initials: A
authors.lastname: Matheu
authors.affiliation: Primary Care Research Unit-Gipuzkoa, Osakidetza, Biodonostia Health Research Institute, San Sebastian 20014, Spain. ivergara@osakidetza.eus.|Health Services Research on Chronic Patients Network (REDISSEC), Bilbao 48013, Spain. ivergara@osakidetza.eus.
authors.forename: Itziar
authors.initials: I
authors.lastname: Vergara
authors.affiliation: Multiple Sclerosis Unit, Biodonostia Health Research Institute-Donostia University Hospital, San Sebastian 20014, Spain. david.otaegui@biodonostia.org.|Spanish Network of Multiple Sclerosis, Barcelona 08028, Spain. david.otaegui@biodonostia.org.
authors.forename: David
authors.initials: D
authors.lastname: Otaegui
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D002450:Cell Communication; D000067128:Extracellular Vesicles / Q000378:metabolism*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6
keywords: extracellular vesicle; frailty; human aging; inflammaging; intercellular communication; interleukin-6