title: Simulating muscular thin films using thermal contraction capabilities in finite element analysis tools.
abstract: In this study, new techniques for approximating the contractile properties of cells in biohybrid devices using Finite Element Analysis (FEA) have been investigated. Many current techniques for modeling biohybrid devices use individual cell forces to simulate the cellular contraction. However, such techniques result in long simulation runtimes. In this study we investigated the effect of the use of thermal contraction on simulation runtime. The thermal contraction model was significantly faster than models using individual cell forces, making it beneficial for rapidly designing or optimizing devices. Three techniques, Stoney׳s Approximation, a Modified Stoney׳s Approximation, and a Thermostat Model, were explored for calibrating thermal expansion/contraction parameters (TECPs) needed to simulate cellular contraction using thermal contraction. The TECP values were calibrated by using published data on the deflections of muscular thin films (MTFs). Using these techniques, TECP values that suitably approximate experimental deflections can be determined by using experimental data obtained from cardiomyocyte MTFs. Furthermore, a sensitivity analysis was performed in order to investigate the contribution of individual variables, such as elastic modulus and layer thickness, to the final calibrated TECP for each calibration technique. Additionally, the TECP values are applicable to other types of biohybrid devices. Two non-MTF models were simulated based on devices reported in the existing literature.
authors.affiliation: Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA. Electronic address: vaw4@case.edu.
authors.forename: Victoria A
authors.initials: VA
authors.lastname: Webster
authors.affiliation: Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA.
authors.forename: Santiago G
authors.initials: SG
authors.lastname: Nieto
authors.affiliation: University of California, Irvine, Irvine, CA 92697, USA.
authors.forename: Anna
authors.initials: A
authors.lastname: Grosberg
authors.affiliation: Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA.
authors.forename: Ozan
authors.initials: O
authors.lastname: Akkus
authors.affiliation: Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA.
authors.forename: Hillel J
authors.initials: HJ
authors.lastname: Chiel
authors.affiliation: Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA.
authors.forename: Roger D
authors.initials: RD
authors.lastname: Quinn
mesh_terms: D002138:Calibration; D003198:Computer Simulation; D055119:Elastic Modulus; D020342:Finite Element Analysis; D006801:Humans; D008954:Models, Biological; D009119:Muscle Contraction; D032383:Myocytes, Cardiac / Q000502:physiology*
keywords: Biohybrid; Finite element analysis; Modeling; Muscular thin films; Thermal contraction