title: Circuit-Based Corticostriatal Homologies Between Rat and Primate.
abstract: Understanding the neural mechanisms of psychiatric disorders requires the use of rodent models; however, frontal-striatal homologies between rodents and primates are unclear. In contrast, within the striatum, the shell of the nucleus accumbens, the hippocampal projection zone, and the amygdala projection zone (referred to as the striatal emotion processing network [EPN]) are conserved across species. We used the relationship between the EPN and projections from the anterior cingulate cortex (ACC) and orbitofrontal cortex (OFC) to assess network similarities across rats and monkeys.
  
  
  
  We first compared the location and extent of each major component of the EPN in rats and macaques. Next, we used anatomic cases with anterograde injections in ACC/OFC to determine the extent to which corticostriatal terminal fields overlapped with these components and with each other.
  
  
  
  The location and size of each component of the EPN were similar across species, containing projections primarily from infralimbic cortex in rats and area 25 in monkeys. Other ACC/OFC terminals overlapped extensively with infralimbic cortex/area 25 projections, supporting cross-species similarities in OFC topography. However, dorsal ACC had different connectivity profiles across species. These results were used to segment the monkey and rat striata according to ACC/OFC inputs.
  
  
  
  Based on connectivity with the EPN, and consistent with prior literature, the infralimbic cortex and area 25 are likely homologues. We also see evidence of OFC homologies. Along with segmenting the striatum and identifying striatal hubs of overlapping inputs, these results help to translate findings between rodent models and human pathology.
authors.affiliation: Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York. Electronic address: suzanne_haber@urmc.rochester.edu.
authors.forename: Sarah R
authors.initials: SR
authors.lastname: Heilbronner
authors.affiliation: Departments of Psychiatry and Anatomy and Neurobiology, University of Puerto Rico School of Medicine, San Juan, Puerto Rico.
authors.forename: Jose
authors.initials: J
authors.lastname: Rodriguez-Romaguera
authors.affiliation: Departments of Psychiatry and Anatomy and Neurobiology, University of Puerto Rico School of Medicine, San Juan, Puerto Rico.
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Quirk
authors.affiliation: Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands.
authors.forename: Henk J
authors.initials: HJ
authors.lastname: Groenewegen
authors.affiliation: Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York.
authors.forename: Suzanne N
authors.initials: SN
authors.lastname: Haber
mesh_terms: D000679:Amygdala / Q000033:anatomy & histology*; D000818:Animals; D003342:Corpus Striatum / Q000033:anatomy & histology*; D006179:Gyrus Cinguli / Q000033:anatomy & histology*; D008251:Macaca / Q000033:anatomy & histology*; D008297:Male; D009434:Neural Pathways / Q000033:anatomy & histology*; D056347:Neuroanatomical Tract-Tracing Techniques; D009714:Nucleus Accumbens / Q000033:anatomy & histology*; D017397:Prefrontal Cortex / Q000033:anatomy & histology*; D051381:Rats; D013045:Species Specificity
keywords: Cingulate; Homology; Infralimbic; Orbitofrontal; Prefrontal; Prelimbic