title: Neurotherapeutic Strategies for Multiple Sclerosis.
abstract: Multiple sclerosis (MS) is the most common disabling neurologic disease of young adults. There are now 16 US Food and Drug Administration (FDA)-approved disease-modifying therapies for MS as well as a cohort of other agents commonly used in practice when conventional therapies prove inadequate. This article discusses approved FDA therapies as well as commonly used practice-based therapies for MS, as well as those therapies that can be used in patients attempting to become pregnant, or in patients with an established pregnancy, who require concomitant treatment secondary to recalcitrant disease activity.
authors.affiliation: Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA; Department of BioEngineering, University of Texas at Dallas, 800 West Campbell Road, Richardson, TX 75080, USA. Electronic address: teresa.frohman@utsouthwestern.edu.
authors.forename: Teresa C
authors.initials: TC
authors.lastname: Frohman
authors.affiliation: Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
authors.forename: Shin C
authors.initials: SC
authors.lastname: Beh
authors.affiliation: Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA; Center for Engineering Innovation, University of Texas at Dallas, Institute for Innovation and Entrepreneurship, 800 West Campbell Road, Richardson, TX 75080, USA.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Kildebeck
authors.affiliation: Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
authors.forename: Ram
authors.initials: R
authors.lastname: Narayan
authors.affiliation: Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
authors.forename: Katherine
authors.initials: K
authors.lastname: Treadaway
authors.affiliation: Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA; Department of Ophthalmology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. Electronic address: elliot.frohman@utsouthwestern.edu.
authors.forename: Elliot M
authors.initials: EM
authors.lastname: Frohman
mesh_terms: D005260:Female; D006801:Humans; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000628:therapy; D011247:Pregnancy
keywords: Adrenocorticotrophic hormone; Corticosteroids; Disease-modifying therapy; Exacerbation; MS; Multiple sclerosis; Pregnancy