title: Nonsurgical options to treat giant-cell tumors of the head and neck: A case report and brief review of the literature.
abstract: Central giant-cell granulomas (CGCGs) are relatively uncommon. When they do occur, they typically arise in the mandible and maxilla. Some lesions are more destructive than others, and the destructive subtype has a tendency to recur. Unfortunately, there is no reproducible way to differentiate aggressive from nonaggressive subtypes. Treatment of CGCG has historically been based on surgical curettage or wide local excision. However, surgery has been associated with significant morbidity, disfigurement, and expense, as well as a high recurrence rate. Pharmacologic treatments-either as an alternative or an adjunct to surgery-have been shown to yield acceptable results. These agents include intralesional and/or systemic corticosteroids, bisphosphonates, calcitonin, and interferon alfa. These options are typically less expensive than surgery, and they are associated with few side effects, which makes them potentially more desirable. We report the case of a 36-year-old woman with a CGCG who was successfully treated with a combination of an intralesional steroid and an oral steroid over a period of 5 months. As evidenced by this case, medical management can be effective for tumor regression in treating CGCG of the head and neck, and it is ultimately associated with less morbidity and is less costly. To the best of our knowledge, no randomized controlled studies have been published on this topic. Such a study would be welcome, particularly considering the presence of both aggressive and nonaggressive subtypes of CGCG. We also briefly review the literature.
authors.affiliation: Corresponding author: Dr. Allison Rasband-Lindquist, Department of Otolaryngology-Head and Neck Surgery, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160. Email: allisonrasband@gmail.com From the Department of Otolaryngology-Head and Neck Surgery (Dr. Rasband-Lindquist, Dr. Larsen, and Dr. Girod) and the Department of Radiology (Dr. Lindquist), University of Kansas Medical Center, Kansas City; and the Department of Otolaryngology-Head and Neck Surgery, University of Missouri Medical Center; Columbia (Dr. Thiessen). The case described in this article occurred at the University of Kansas Medical Center.
authors.forename: Allison N
authors.initials: AN
authors.lastname: Rasband-Lindquist
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Lindquist
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Larsen
authors.forename: Aaron
authors.initials: A
authors.lastname: Thiessen
authors.forename: Douglas
authors.initials: D
authors.lastname: Girod
mesh_terms: D000284:Administration, Oral; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D005260:Female; D006101:Granuloma, Giant Cell / Q000188:drug therapy*; D006258:Head and Neck Neoplasms / Q000188:drug therapy*; D006801:Humans; D015552:Injections, Intralesional; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000970:Antineoplastic Agents