title: Brain activation difference evoked by different binocular disparities of stereograms: An fMRI study.
abstract: The binocular disparity of two retina images is a main cue of stereoscopic vision. However, the global dependency between brain response and binocular disparity still remains unclear. Here, we used functional Magnetic Resonance Imaging (fMRI) to identify stereopsis-related brain regions with a modified Random Dot Stereogram (RDS) and plotted the activation variation curves under different disparity size. In order to eliminate the confounding shape difference between the stereogram and the plane, commonly seen in RDS, we modified the RDS to a checkerboard version. We found that V3A, V7 and MT+/V5 in dorsal visual stream were activated in stereoscopic experiment, while little activation was found in ventral visual regions. According to the activation trends, 13 subjects were divided into three groups: 5 subjects with turning points (a shift from increased to decreased activation), 5 subjects without turning points and 3 subjects with activation unrelated to disparity. We inferred that the dorsal visual stream primarily processes spatial depth information, rather than shape information.
authors.affiliation: Medical Physics Department, Health Science Center of Peking University, Beijing 100191, China; Beijing City Key Laboratory of Medical Physics and Engineering, Peking University, Beijing 100871, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.affiliation: Beijing City Key Laboratory of Medical Physics and Engineering, Peking University, Beijing 100871, China.
authors.forename: Wenchao
authors.initials: W
authors.lastname: Yang
authors.affiliation: Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing 100005, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Neuroscience Charleston, Medical University of South Carolina, SC 29425, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Gundran
authors.affiliation: Department of Neuroscience Charleston, Medical University of South Carolina, SC 29425, USA.
authors.forename: Xun
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Medical Physics Department, Health Science Center of Peking University, Beijing 100191, China.
authors.forename: Jiajia
authors.initials: J
authors.lastname: Liu
authors.affiliation: Basic Medical College, Hebei North University, Zhangjiakou 050024, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.affiliation: Beijing City Key Laboratory of Medical Physics and Engineering, Peking University, Beijing 100871, China.
authors.forename: Shanglian
authors.initials: S
authors.lastname: Bao
authors.affiliation: Medical Physics Department, Health Science Center of Peking University, Beijing 100191, China; Beijing City Key Laboratory of Medical Physics and Engineering, Peking University, Beijing 100871, China. Electronic address: gaoss@bjmu.edu.cn.
authors.forename: Song
authors.initials: S
authors.lastname: Gao
mesh_terms: D000328:Adult; D055592:Biophysical Phenomena; D003867:Depth Perception / Q000502:physiology*; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D059907:Functional Neuroimaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010775:Photic Stimulation; D015357:Vision Disparity / Q000502:physiology*; D015348:Vision, Binocular / Q000502:physiology; D014793:Visual Cortex / Q000502:physiology*; D055815:Young Adult
keywords: Binocular disparity; Depth perception; Human vision; Stereopsis; fMRI