title: The Dynamics of Apoptotic Cell Clearance.
abstract: The phagocytic clearance of dying cells in a tissue is a highly orchestrated series of intercellular events coordinated by a complex signaling network. Recent data from genetic, biochemical, and live-imaging approaches have greatly enhanced our understanding of the dynamics of cell clearance and how the process is orchestrated at the cellular and tissue levels. We discuss how networks regulating apoptotic cell clearance are integrated to enable a rapid, efficient, and high-capacity clearance system within tissues.
authors.affiliation: Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA; David H. Smith Center for Vaccine Biology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA. Electronic address: michael_elliott@urmc.rochester.edu.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Elliott
authors.affiliation: Department of Microbiology, Immunology, Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA; Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA; Center for Cell Clearance, University of Virginia, Charlottesville, VA 22908, USA. Electronic address: ravi@virginia.edu.
authors.forename: Kodi S
authors.initials: KS
authors.lastname: Ravichandran
mesh_terms: D000818:Animals; D017209:Apoptosis; D006801:Humans; D010587:Phagocytosis / Q000502:physiology*; D015398:Signal Transduction
keywords: apoptosis; chemotaxis; efferocytosis; imaging; immunity; phagocytosis; signal transduction