title: Alpha Linolenic Acid-enriched Diacylglycerol Enhances Postprandial Fat Oxidation in Healthy Subjects: A Randomized Double-blind Controlled Trail.
abstract: Alpha linolenic acid-enriched diacylglycerol (ALA-DAG) reduces visceral fat area and body fat in rodents and humans compared to conventional triacylglycerol (TAG). Although ALA-DAG increases dietary fat utilization as energy in rodents, its effects in humans are not known. The present study was a randomized, placebo-controlled, double-blind, crossover intervention trial performed to clarify the effect of ALA-DAG on postprandial energy metabolism in humans. Nineteen healthy subjects participated in this study, and postprandial energy metabolism was evaluated using indirect calorimetry followed by 14-d repeated pre-consumption of TAG (rapeseed oil) as a control or ALA-DAG. As a primary outcome, ALA-DAG induced significantly higher postprandial fat oxidation than TAG. As a secondary outcome, carbohydrate oxidation tended to be decreased. In addition, postprandial energy expenditure was significantly increased by ALA-DAG compared to TAG. These findings suggest that daily ALA-DAG consumption stimulates dietary fat utilization as energy after a meal, as well as greater diet induced thermogenesis in healthy humans. In conclusion, repeated consumption of ALA-DAG enhanced postprandial fat metabolism after a meal, which may partially explain its visceral fat area-reducing effect.
authors.affiliation: Healthcare Food Research Laboratories, Kao Corporation.
authors.forename: Yasutoshi
authors.initials: Y
authors.lastname: Ando
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Saito
authors.forename: Sachiko
authors.initials: S
authors.lastname: Oishi
authors.forename: Nami
authors.initials: N
authors.lastname: Yamanaka
authors.forename: Masanobu
authors.initials: M
authors.lastname: Hibi
authors.forename: Noriko
authors.initials: N
authors.lastname: Osaki
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Katsuragi
mesh_terms: D000284:Administration, Oral; D000328:Adult; D002151:Calorimetry; D004032:Diet; D004075:Diglycerides / Q000008:administration & dosage / Q000494:pharmacology*; D004311:Double-Blind Method; D002149:Energy Intake / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects; D005223:Fats / Q000378:metabolism*; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction / Q000187:drug effects; D019518:Postprandial Period / Q000187:drug effects; D017962:alpha-Linolenic Acid / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: C011439:1,2-diacylglycerol; D004075:Diglycerides; D005223:Fats; D017962:alpha-Linolenic Acid