title: Comparison of dorzolamide/timolol vs brinzolamide/brimonidine fixed combination therapy in the management of primary open-angle glaucoma.
abstract: OBJECTIVE
  To compare the efficiency of brinzolamide/brimonidine fixed combination vs the dorzolamide/timolol fixed combination.
  
  
  METHODS
  Forty-four eyes of 44 patients were divided in 2 groups treated either with dorzolamide/timolol twice a day (group A) or with brinzolamide/brimonidine twice a day (group B). Complete ophthalmic examination including Goldmann applanation tonometry was performed before treatment administration and 1, 4, 8, and 12 weeks afterwards. The intraocular pressure (IOP) was measured twice a day (morning at 9 AM and afternoon at 4 PM).
  
  
  RESULTS
  At the end of the follow-up period (12 weeks), mean morning IOP reduction was 7.0 ± 2.8 mm Hg in group A and 8.4 ± 1.9 mm Hg in group B. A significant difference was found (p = 0.0343). In contrast, mean afternoon IOP reduction was 8.6 ± 2.7 mm Hg in group A and 7.9 ± 1.6 mm Hg in group B and no significant difference was found (p = 0.3413). No significant adverse effects were observed in either group.
  
  
  CONCLUSIONS
  Brinzolamide/brimonidine seems to be an effective and safe alternative β-blocker free fixed combination, especially for patients with comorbidities, having its own antihypertensive profile.
authors.affiliation:  Department of Ophthalmology, University General Hospital of Evros, Alexandroupolis - Greece.| Eye Institute of Thrace, School of Medicine, University of Thrace, Alexandroupolis - Greece.| Glaucoma Laser Eye Center, Athens - Greece.
authors.forename: Vassileios
authors.initials: V
authors.lastname: Kozobolis
authors.affiliation:  Eye Institute of Thrace, School of Medicine, University of Thrace, Alexandroupolis - Greece.
authors.forename: Georgios D
authors.initials: GD
authors.lastname: Panos
authors.affiliation:  Department of Ophthalmology, University General Hospital of Evros, Alexandroupolis - Greece.
authors.forename: Aristeidis
authors.initials: A
authors.lastname: Konstantinidis
authors.affiliation:  Department of Ophthalmology, University General Hospital of Evros, Alexandroupolis - Greece.| Eye Institute of Thrace, School of Medicine, University of Thrace, Alexandroupolis - Greece.
authors.forename: Georgios
authors.initials: G
authors.lastname: Labiris
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000188:drug therapy; D009883:Ophthalmic Solutions / Q000627:therapeutic use; D011446:Prospective Studies; D013449:Sulfonamides / Q000627:therapeutic use*; D013843:Thiazines / Q000627:therapeutic use*; D013876:Thiophenes / Q000627:therapeutic use*; D013999:Timolol / Q000627:therapeutic use*; D014065:Tonometry, Ocular; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D004338:Drug Combinations; D009883:Ophthalmic Solutions; D013449:Sulfonamides; D013843:Thiazines; D013876:Thiophenes; C479140:dorzolamide-timolol combination; D013999:Timolol; C111827:brinzolamide; C062765:dorzolamide