title: Autoantibodies in Sjögren's Syndrome.
abstract: We compiled information on antibodies in Sjögren syndrome, focusing more on clinical manifestations associated with anti-Ro/SSA and anti-La/SSB antibodies and studies regarding novel antibodies. We reviewed previous as well as most recent studies with the subject heading Sjogren in combination with antibodies and congenital heart block (CHB). Almost half of asymptomatic mothers giving birth to children with CHB ultimately develop Sjögren. We discussed studies concerning the presence of antibodies predating clinical manifestations of disease. Studies in the future are required to ascertain the pathogenic mechanisms associated with these antibodies and the specific clinical manifestation related to new autoantibodies.
authors.affiliation: Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, 825 Northeast, 13th Street, Oklahoma City, OK 73104, USA; Department of Medicine, College of Medicine, 1000 N Lincoln Boulevard, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA; Medical and Research Services, US Department of Veterans Affairs Hospital, 921 NE 13th Street, Oklahoma City, OK 73104, USA.
authors.forename: Anum
authors.initials: A
authors.lastname: Fayyaz
authors.affiliation: Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, 825 Northeast, 13th Street, Oklahoma City, OK 73104, USA; Department of Medicine, College of Medicine, 1000 N Lincoln Boulevard, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA; Medical and Research Services, US Department of Veterans Affairs Hospital, 921 NE 13th Street, Oklahoma City, OK 73104, USA.
authors.forename: Biji T
authors.initials: BT
authors.lastname: Kurien
authors.affiliation: Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, 825 Northeast, 13th Street, Oklahoma City, OK 73104, USA; Department of Medicine, College of Medicine, 1000 N Lincoln Boulevard, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA; Medical and Research Services, US Department of Veterans Affairs Hospital, 921 NE 13th Street, Oklahoma City, OK 73104, USA. Electronic address: Hal-Scofield@omrf.ouhsc.edu.
authors.forename: R Hal
authors.initials: RH
authors.lastname: Scofield
mesh_terms: D000974:Antibodies, Antinuclear / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology* / Q000378:metabolism; D018450:Disease Progression; D005260:Female; D006327:Heart Block / Q000151:congenital / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D008180:Lupus Erythematosus, Systemic / Q000151:congenital / Q000276:immunology; D010456:Peptides, Cyclic / Q000276:immunology; D011247:Pregnancy; D043587:Receptor, Muscarinic M3 / Q000276:immunology; D012217:Rheumatoid Factor / Q000276:immunology; D012859:Sjogren's Syndrome / Q000276:immunology*
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D010456:Peptides, Cyclic; D043587:Receptor, Muscarinic M3; C035356:SS-A antibodies; C035357:SS-B antibodies; C538950:anticentromere antibody; C487763:cyclic citrullinated peptide; D012217:Rheumatoid Factor
keywords: Autoantibodies; Congenital heart block; Sjögren’s syndrome