title: Anthelmintic activity of silver-extract nanoparticles synthesized from the combination of silver nanoparticles and M. charantia fruit extract.
abstract: BACKGROUND
  Present study has been conducted to know the anthelmintic activity of polyaniline coated silver nanoparticles (AgNPs) synthesized from Momordica charantia fruit extract.
  
  
  METHODS
  By reduction of AgNO3 in presence of NaBH4, silver nanoparticles were prepared. After mixing silver nanoparticles and extracts, coating was given on nanoparticles using polyaniline. Prepared nanoparticles were characterized by Visual, UV, FTIR spectroscopy, SEM techniques, and TEM analysis.
  
  
  RESULTS
  The FTIR results implied that AgNPs were successfully synthesized and capped with bio-compounds present in the extract. The result showed that death times of worm were 35.12 ± 0.5 and 59.3 ± 0.3 minutes for M. charantia extract and Ag-nanoparticles individually. But when these two combined together, paralysis and death time fall drastically which were only 6.16 ± 0.6 and 9.1 ± 0.4 minutes respectively. Albendazole tablet was used as standard, which made worms death in 3.66 ± 0.1 minutes.
  
  
  CONCLUSIONS
  Ag-Extract NPs showed strong anthelmintic activity against worm. This study has paved the way for further research to design new anthelmintic drug from the combination of M. charantia and AgNPs.
authors.affiliation: Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali, 3814, Bangladesh. mamun_nstu@yahoo.com.
authors.forename: Md Mamun Or
authors.initials: MM
authors.lastname: Rashid
authors.affiliation: Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali, 3814, Bangladesh.
authors.forename: Jannatul
authors.initials: J
authors.lastname: Ferdous
authors.affiliation: Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali, 3814, Bangladesh.
authors.forename: Sujan
authors.initials: S
authors.lastname: Banik
authors.affiliation: Department of Pharmacy, International Islamic University Chittagong, Chandgaon R/A, Chittagong, Bangladesh.
authors.forename: Md Rabiul
authors.initials: MR
authors.lastname: Islam
authors.affiliation: Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali, 3814, Bangladesh.
authors.forename: A H M Mazbah
authors.initials: AH
authors.lastname: Uddin
authors.affiliation: Department of Applied Chemistry and Chemical Engineering, Noakhali Science and Technology University, Sonapur, Noakhali, 3814, Bangladesh.
authors.forename: Fataha Nur
authors.initials: FN
authors.lastname: Robel
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000737:chemistry / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D029777:Momordica charantia / Q000737:chemistry*; D009835:Oligochaeta / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D012834:Silver / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000871:Anthelmintics; D010936:Plant Extracts; D012834:Silver
keywords: Ag-Extract nanoparticles; Anthelmintic activity; M. charantia; Silver Nanoparticles (AgNPs)