title: Increased serum levels of novel T cell cytokines IL-33, IL-9 and IL-17 in subjects with type-1 diabetes.
abstract: The role of adaptive immune cytokines in the pathogenesis of type-1 Diabetes Mellitus (T1DM) is well known. Even though reports on the serum levels of both Th-1 and Th-2 cytokines are available, those on newly described T cell cytokines such as IL-17, IL-33 and IL-9 in T1DM are scarce. We therefore measured the serum levels of both T cell polarizing (IL-33 and IL-12) and T cell effector (IFN-γ, IL-4, IL-10, IL-17 and IL-9) cytokines in T1DM subjects with and without microvascular (retinopathy and nephropathy) complications (MVC). All the tested cytokines were significantly elevated in T1DM subjects except for IFN-γ (which failed to attain statistical significance) with no significant difference between those with and without MVC. From the serum cytokine analysis, no apparent Th polarization could be determined for the T1DM subjects.
authors.affiliation: Dept of Genetics, Dr ALM PG IBMS, University of Madras, Taramani, Chennai, India.
authors.forename: Sugumar
authors.initials: S
authors.lastname: Shruthi
authors.affiliation: Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialties Centre, WHO Collaborating Centre for Non-Communicable Diseases Prevention and Control, Chennai, India.
authors.forename: Viswanathan
authors.initials: V
authors.lastname: Mohan
authors.affiliation: Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialties Centre, WHO Collaborating Centre for Non-Communicable Diseases Prevention and Control, Chennai, India.
authors.forename: Anandakumar
authors.initials: A
authors.lastname: Amutha
authors.affiliation: Dept of Genetics, Dr ALM PG IBMS, University of Madras, Taramani, Chennai, India. Electronic address: cvaravindhan@gmail.com.
authors.forename: Vivekanandhan
authors.initials: V
authors.lastname: Aravindhan
mesh_terms: D000293:Adolescent; D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000175:diagnosis / Q000276:immunology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood; D016753:Interleukin-10 / Q000097:blood; D020381:Interleukin-17 / Q000097:blood*; D000067596:Interleukin-33 / Q000097:blood*; D015847:Interleukin-4 / Q000097:blood; D016906:Interleukin-9 / Q000097:blood*; D008297:Male; D018417:Th1 Cells / Q000276:immunology / Q000502:physiology; D018418:Th2 Cells / Q000276:immunology / Q000502:physiology; D055815:Young Adult
chemical_list: C508609:IL10 protein, human; C506536:IL33 protein, human; C508598:IL4 protein, human; C508607:IL9 protein, human; D020381:Interleukin-17; D000067596:Interleukin-33; D016906:Interleukin-9; D016753:Interleukin-10; D015847:Interleukin-4; D007371:Interferon-gamma
keywords: Adaptive cytokines; IL-17; IL-33; IL-9; T cell cytokines; Type-1 diabetes