title: The Use of Genetic Markers in Studies of Myeloid Neoplasia.
abstract: We have focused this review on some aspects of the use of genetic markers in analyses of cell lineage relationships in myeloid leukemia relying predominantly on studies of women heterozygous for G6PD. We have emphasized the advantages of using markers which are extrinsic to the clonal process and if possible, combining them with markers intrinsic to the neoplastic clone. It is likely that additional intrinsic markers will become available as the multiple genetic defects leading to neoplastic transformation are elucidated. However, it is probable that these will prove to be markers of subclonal evolution and only by relying on cell markers that antedate the occurrence of neoplasia will it be possible to fully appreciate its multistep nature.
authors.affiliation: a Medical Service, VA Medical Center, the Department of Medicine, Divisions of Medical Oncology and Medical Genetics, the University of Washington and the Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
authors.forename: J W
authors.initials: JW
authors.lastname: Singer
authors.affiliation: a Medical Service, VA Medical Center, the Department of Medicine, Divisions of Medical Oncology and Medical Genetics, the University of Washington and the Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
authors.forename: P J
authors.initials: PJ
authors.lastname: Fialkow
keywords: Genetic markers; myeloid neoplasia