title: Regression of Cardiac Rhabdomyomas in a Neonate after Everolimus Treatment.
abstract: Cardiac rhabdomyoma often shows spontaneous regression and usually requires only close follow-up. However, patients with symptomatic inoperable rhabdomyomas may be candidates for everolimus treatment. Our patient had multiple inoperable cardiac rhabdomyomas causing serious left ventricle outflow-tract obstruction that showed a dramatic reduction in the size after everolimus therapy, a mammalian target of rapamycin (mTOR) inhibitor. After discontinuation of therapy, an increase in the diameter of masses occurred and everolimus was restarted. After 6 months of treatment, rhabdomyomas decreased in size and therapy was stopped. In conclusion, everolimus could be a possible novel therapy for neonates with clinically significant rhabdomyomas.
authors.affiliation: Department of Pediatric Cardiology, Kanuni Suleyman Teaching and Research Hospital, 34303 Istanbul, Turkey.
authors.forename: Helen
authors.initials: H
authors.lastname: Bornaun
authors.affiliation: Department of Pediatric Cardiology, Kanuni Suleyman Teaching and Research Hospital, 34303 Istanbul, Turkey.
authors.forename: Kazım
authors.initials: K
authors.lastname: Öztarhan
authors.affiliation: Department of Neonatology, Kanuni Suleyman Teaching and Research Hospital, 34303 Istanbul, Turkey.
authors.forename: Tugba
authors.initials: T
authors.lastname: Erener-Ercan
authors.affiliation: Department of Pediatric Cardiology, Cerrahpasa Medical Faculty, Istanbul University, 34098 Istanbul, Turkey.
authors.forename: Reyhan
authors.initials: R
authors.lastname: Dedeoğlu
authors.affiliation: Department of Pediatric Hematology-Oncology, Kanuni Suleyman Teaching and Research Hospital, 34303 Istanbul, Turkey.
authors.forename: Deniz
authors.initials: D
authors.lastname: Tugcu
authors.affiliation: Department of Neonatology, Kanuni Suleyman Teaching and Research Hospital, 34303 Istanbul, Turkey.
authors.forename: Çiğdem
authors.initials: Ç
authors.lastname: Aydoğmuş
authors.affiliation: Department of Neonatology, Kanuni Suleyman Teaching and Research Hospital, 34303 Istanbul, Turkey.
authors.forename: Merih
authors.initials: M
authors.lastname: Cetinkaya
authors.affiliation: Department of Neonatology, Kanuni Suleyman Teaching and Research Hospital, 34303 Istanbul, Turkey.
authors.forename: Sultan
authors.initials: S
authors.lastname: Kavuncuoglu