title: Biosurfactant/s from Lactobacilli species: Properties, challenges and potential biomedical applications.
abstract: Lactic acid bacteria are generally believed to have positive roles in maintaining good health and immune system in humans. A number of Lactobacilli spp. are known to produce important metabolites, among which biosurfactants in particular have shown antimicrobial activity against several pathogens in the intestinal tract and female urogenital tract partly through interfering with biofilm formation and adhesion to the epithelial cells surfaces. Around 46 reports are documented on biosurfactant production from Lactobacillus spp. of which six can be broadly classified as cell free biosurfactant and 40 as cell associated biosurfactants and only approximately 50% of those have reported on the structural composition which, in order of occurrence were mainly proteinaceous, glycolipidic, glycoproteins, or glycolipopeptides in nature. Due to the proteinaceous nature, most biosurfactant produced by strains of Lactobacillus are generally believed to be surlactin type with high potential toward impeding pathogens adherence. Researchers have recently focused on the anti-adhesive and antibiofilm properties of Lactobacilli-derived biosurfactants. This review briefly discusses the significance of Lactobacilli-derived biosurfactants and their potential applications in various fields. In addition, we highlight the exceptional prospects and challenges in fermentation economics of Lactobacillus spp.-derived biosurfactants' production processes.
authors.affiliation: Department of Physics, Centre for Advanced Studies in Materials Science and Condensed Matter Physics, Savitribai Phule Pune University, Pune, Maharashtra, India.
authors.forename: Surekha K
authors.initials: SK
authors.lastname: Satpute
authors.affiliation: Department of Physics, Centre for Advanced Studies in Materials Science and Condensed Matter Physics, Savitribai Phule Pune University, Pune, Maharashtra, India.|Department of Physics, School of Basic Medical Sciences, Savitribai Phule Pune University, Pune, Maharashtra, India.
authors.forename: Gauri R
authors.initials: GR
authors.lastname: Kulkarni
authors.affiliation: Department of Physics, Centre for Advanced Studies in Materials Science and Condensed Matter Physics, Savitribai Phule Pune University, Pune, Maharashtra, India.
authors.forename: Arun G
authors.initials: AG
authors.lastname: Banpurkar
authors.affiliation: School of Biomedical Sciences, University of Ulster, Coleraine, N. Ireland, UK.
authors.forename: Ibrahim M
authors.initials: IM
authors.lastname: Banat
authors.affiliation: Department of Physics, Centre for Advanced Studies in Materials Science and Condensed Matter Physics, Savitribai Phule Pune University, Pune, Maharashtra, India.
authors.forename: Nishigandha S
authors.initials: NS
authors.lastname: Mone
authors.affiliation: Department of Biotechnology, Savitribai Phule Pune University, Pune, Maharashtra, India.
authors.forename: Rajendra H
authors.initials: RH
authors.lastname: Patil
authors.affiliation: Institute of Microbial Technology, Chandigarh, India.
authors.forename: Swaranjit Singh
authors.initials: SS
authors.lastname: Cameotra
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001422:Bacterial Adhesion / Q000187:drug effects; D001426:Bacterial Proteins / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D018441:Biofilms; D035843:Biomedical Research; D004847:Epithelial Cells / Q000382:microbiology; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D005285:Fermentation; D006017:Glycolipids / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D006023:Glycoproteins / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D007778:Lactobacillus / Q000737:chemistry / Q000378:metabolism*; D013501:Surface-Active Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D006017:Glycolipids; D006023:Glycoproteins; D013501:Surface-Active Agents
keywords: Biofilm; Biomedical; Biosurfactant; Lactobacilli; Surlactin