title: Magnetic Solid-Phase Extraction Based on β-Cyclodextrins/Acrylic Acid Modified Magnetic Gelatin for Determination of Moxidectin in Milk Samples.
abstract: β-Cyclodextrins/acrylic acid modified magnetic gelatin was prepared and then employed as the magnetic solid-phase extraction (MSPE) sorbent for extraction of moxidectin in milk samples. Due to the rigidity of hydrophobic cavity of β-cyclodextrins and carboxyl groups of acrylic acid, magnetic composites are prepared to form a complex with target molecules through various kinds of chemical reactions and then showed excellent extraction performance. This method exhibits the advantages of simplicity of implementation, short extraction time (5 min), low solvent consumption, and high extraction efficiency. A rapid, simple, and effective method for the analysis of moxidectin in milk samples was established by MSPE coupled with liquid chromatography-fluorescence detection. The limit of detection was 0.1 ng·mL(-1) and the recoveries from milk samples were in the range of 93.8%-112.5%. The relative standard deviation was not higher than 6.4%. In conclusion, magnetic solid-phase extraction is a simple and robust preconcentration technique that can be coupled to other analytical methods for the quantitative determination of target molecules in complex samples.
authors.affiliation: Hubei Entry-Exit Inspection and Quarantine Bureau of PRC, Wuhan 430022, China.
authors.forename: Yinzhu
authors.initials: Y
authors.lastname: Shang
authors.affiliation: Hubei Entry-Exit Inspection and Quarantine Bureau of PRC, Wuhan 430022, China.
authors.forename: Jing
authors.identifier: 0000-0003-1048-2624
authors.initials: J
authors.lastname: Luo
authors.affiliation: Hubei Entry-Exit Inspection and Quarantine Bureau of PRC, Wuhan 430022, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.affiliation: Hubei Entry-Exit Inspection and Quarantine Bureau of PRC, Wuhan 430022, China.
authors.forename: Xiaoya
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Hubei Entry-Exit Inspection and Quarantine Bureau of PRC, Wuhan 430022, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Ye
authors.affiliation: Hubei Entry-Exit Inspection and Quarantine Bureau of PRC, Wuhan 430022, China.
authors.forename: Shaofei
authors.initials: S
authors.lastname: Guo