title: Krüppel-Like Factor 12 Promotes Colorectal Cancer Growth through Early Growth Response Protein 1.
abstract: Krüppel-like factor 12 (KLF12) is a transcription factor that plays a role in normal kidney development and repression of decidualization. KLF12 is frequently elevated in esophageal adenocarcinoma and has been reported to promote gastric cancer progression. Here, we examined the role of KLF12 in colorectal cancer (CRC). Indeed, KLF12 promotes tumor growth by directly activating early growth response protein 1 (EGR1). The levels of KLF12 and EGR1 correlate synergistically with a poor prognosis. These results indicate that KLF12 likely plays an important role in CRC and could serve as a potential prognostic marker and therapeutic target.
authors.affiliation: Departments of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.
authors.forename: Sun-Hee
authors.initials: SH
authors.lastname: Kim
authors.affiliation: ASAN Institute for Life Sciences, ASAN Medical Center, Department of Medicine, University of Ulsan College of Medicine, Seoul 138-736, Korea.
authors.forename: Yun-Yong
authors.initials: YY
authors.lastname: Park
authors.affiliation: Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.
authors.forename: Sung-Nam
authors.initials: SN
authors.lastname: Cho
authors.affiliation: Biodesign Institute of Arizona State University, Tempe, Arizona, United States of America.
authors.forename: Ofer
authors.initials: O
authors.lastname: Margalit
authors.affiliation: Biodesign Institute of Arizona State University, Tempe, Arizona, United States of America.
authors.forename: Dingzhi
authors.initials: D
authors.lastname: Wang
authors.affiliation: Biodesign Institute of Arizona State University, Tempe, Arizona, United States of America.|Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona, United States of America.|Department of Research and Division of Gastroenterology, Mayo Clinic, Scottsdale, Arizona, United States of America.|Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America.
authors.forename: Raymond N
authors.initials: RN
authors.lastname: DuBois
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D051766:Early Growth Response Protein 1 / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D055785:Gene Knockdown Techniques; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000378:metabolism*; D011379:Prognosis; D011401:Promoter Regions, Genetic; D011485:Protein Binding
chemical_list: D051766:Early Growth Response Protein 1; C436492:KLF12 protein, human; D051741:Kruppel-Like Transcription Factors