title: Functional improvement assessed by multifocal electroretinogram after Ocriplasmin treatment for vitreomacular traction.
abstract: BACKGROUND
  To evaluate the functional recovery of patients with symptomatic vitreomacular traction (VMT) after Ocriplasmin treatment.
  
  
  METHODS
  Prospective, single centre, consecutive case series. Patients were treated with a single intravitreal injection of Ocriplasmin (Jetrea, Thrombogenics Inc, USA, Alcon/Novartis EU). The following outcome measures are considered: resolution of VMT, evaluated through the use of optical coherence tomography (SD-OCT), functional recovery evidenced by multifocal-electroretinogram (mfERG) and microperimetry (MP1) after treatment with Ocriplasmin.
  
  
  RESULTS
  Four eyes of four patients were treated with Ocriplasmin injection. We observed a VMT non-surgical resolution in all patients. The longitudinal statistical analysis showed a significant improvement of best corrected visual acuity (BCVA) in the treated eye of about 0.97 letters/week (p = 0.033). No significant difference was observed in mean sensitivity (p > 0.05) assessed by MP1 in both eyes, while improvement in fixation stability was assessed in treated eyes (β = 0.39; p = 0.029). In the four treated eyes mfERG revealed an increased foveal peak response over the follow-up. The longitudinal analysis of mfERG data shows a significant increase of N1 and P1 amplitude in the first rings and a significant decrease of N1 and P1 implicit time in most rings.
  
  
  CONCLUSIONS
  We report on four cases with resolution of VMT after Ocriplasmin treatment. Our preliminary results demonstrate that Ocriplasmin is safe and effective in the treatment of VMT, because it not only leads to a morphological recovery but mostly to a restoration of macular functionality, evaluated through the use of different objective tests, such as MP1 and mfERG over a six-month follow-up.
authors.affiliation: Eye clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, Second University of Naples, Via Sergio Pansini, 5, 80131, Naples, Italy. settimio.rossi@unina2.it.
authors.forename: Settimio
authors.initials: S
authors.lastname: Rossi
authors.affiliation: Eye clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, Second University of Naples, Via Sergio Pansini, 5, 80131, Naples, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Testa
authors.affiliation: Eye clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, Second University of Naples, Via Sergio Pansini, 5, 80131, Naples, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Melillo
authors.affiliation: Eye clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, Second University of Naples, Via Sergio Pansini, 5, 80131, Naples, Italy.
authors.forename: Ada
authors.initials: A
authors.lastname: Orrico
authors.affiliation: Eye clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, Second University of Naples, Via Sergio Pansini, 5, 80131, Naples, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Della Corte
authors.affiliation: Eye clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, Second University of Naples, Via Sergio Pansini, 5, 80131, Naples, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Simonelli
mesh_terms: D000368:Aged; D004596:Electroretinography / Q000379:methods; D005260:Female; D005341:Fibrinolysin / Q000627:therapeutic use*; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D005403:Fixation, Ocular / Q000502:physiology; D006801:Humans; D058449:Intravitreal Injections; D008875:Middle Aged; D010446:Peptide Fragments / Q000627:therapeutic use*; D011446:Prospective Studies; D012164:Retinal Diseases / Q000188:drug therapy* / Q000503:physiopathology; D012167:Retinal Perforations / Q000188:drug therapy; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D014794:Visual Fields / Q000502:physiology; D020255:Vitreous Detachment / Q000188:drug therapy
chemical_list: D005343:Fibrinolytic Agents; D010446:Peptide Fragments; C054561:microplasmin; D005341:Fibrinolysin
keywords: Multifocal electroretinogram; Ocriplasmin; Optical coherence tomography; Vitreomacular traction