title: Current Stem Cell Biomarkers and Their Functional Mechanisms in Prostate Cancer.
abstract: Currently there is little effective treatment available for castration resistant prostate cancer, which is responsible for the majority of prostate cancer related deaths. Emerging evidence suggested that cancer stem cells might play an important role in resistance to traditional cancer therapies, and the studies of cancer stem cells (including specific isolation and targeting on those cells) might benefit the discovery of novel treatment of prostate cancer, especially castration resistant disease. In this review, we summarized major biomarkers for prostate cancer stem cells, as well as their functional mechanisms and potential application in clinical diagnosis and treatment of patients.
authors.affiliation: The Department of Urology, Affiliated Sixth People's Hospital, Shanghai JiaoTong University, Shanghai 200233, China. great_z0313@126.com.|Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC 27101, USA. great_z0313@126.com.
authors.forename: Kaile
authors.initials: K
authors.lastname: Zhang
authors.affiliation: The Department of Urology, Affiliated Sixth People's Hospital, Shanghai JiaoTong University, Shanghai 200233, China. 2005507098@163.com.
authors.forename: Shukui
authors.initials: S
authors.lastname: Zhou
authors.affiliation: VIP Department of Beijing Hospital, Beijing 100730, China. luckyleileiaaa@sina.com.
authors.forename: Leilei
authors.initials: L
authors.lastname: Wang
authors.affiliation: Urology Department of Beijing Hospital, Beijing 100730, China. wjlspplaaa@sina.com.
authors.forename: Jianlong
authors.initials: J
authors.lastname: Wang
authors.affiliation: The Department of Urology, Affiliated Sixth People's Hospital, Shanghai JiaoTong University, Shanghai 200233, China. zou_qingsong@126.com.
authors.forename: Qingsong
authors.initials: Q
authors.lastname: Zou
authors.affiliation: Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC 27101, USA. wezhao@wakehealth.edu.
authors.forename: Weixin
authors.initials: W
authors.lastname: Zhao
authors.affiliation: The Department of Urology, Affiliated Sixth People's Hospital, Shanghai JiaoTong University, Shanghai 200233, China. jamesqfu@aliyun.com.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Fu
authors.affiliation: Department of Cancer Biology, Wake Forest University School of Medicine, Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC 27101, USA. afang@nygenome.org.
authors.forename: Xiaolan
authors.initials: X
authors.lastname: Fang
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism*; D006801:Humans; D008297:Male; D014411:Neoplastic Stem Cells / Q000378:metabolism / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy*
chemical_list: D015415:Biomarkers
keywords: cancer stem cell; prostate cancer; stem cell biomarker