title: In Vitro Biocompatibility Assessment and In Vivo Behavior of a New Osteoconductive βTCP Bone Substitute.
abstract: OBJECTIVE
  Beta-tricalcium phosphate (βTCP) granules (OsproLife) exhibit a pure crystalline phase and a rough microporous surface for promoting cell adhesion and microsized intragranule porosity for improving wettability and resorption necessary for bone regeneration. OsproLife is a fully resorbable, space-maintaining, and osteoconductive synthetic material for the filling of bone defects. To asses OsproLife properties, a similar synthetic biomaterial, already on the market, has been chosen as reference: Cerasorb has the same chemical composition, but different crystal structure, surface morphology, and granule size. The aim of this study is to compare the properties of OsproLife and Cerasorb.
  
  
  METHODS
  Chemical purity, composition and physical properties, in vitro cytotoxicity, and in vivo bone performance in a rabbit model were analyzed. βTCP OsproLife granules (test) were compared with Cerasorb (control). Histological and μCT analyses were performed at 6, 12, and 56 weeks after implantation.
  
  
  RESULTS
  βTCP OsproLife and Cerasorb granules result to be both biocompatible and characterized by the same osteoconductivity and resorption rate.
  
  
  CONCLUSIONS
  βTCP OsproLife granules are a promising bone substitute for dental and orthopedic applications.
authors.affiliation: *Material Engineer, Research and Development Department, Eurocoating SpA, Cirè-Pergine Valsugana, Trento, Italy. †Chemist, Research and Development Department, Eurocoating SpA, Cirè-Pergine Valsugana, Trento, Italy. ‡Biomedical Engineer, Research and Development Department, Eurocoating SpA, Cirè-Pergine Valsugana, Trento, Italy. §Private Practice, Genova, Italy; Co-Chairman, International Piezosurgery Academy, Parma, Italy. ¶R & D Manager, Research and Development Department, Eurocoating SpA, Cirè-Pergine Valsugana, Trento, Italy.
authors.forename: Marzio
authors.initials: M
authors.lastname: Piccinini
authors.forename: Susanna
authors.initials: S
authors.lastname: Prosperi
authors.forename: Eleonora
authors.initials: E
authors.lastname: Preve
authors.forename: Alberto
authors.initials: A
authors.lastname: Rebaudi
authors.forename: Francesco
authors.initials: F
authors.lastname: Bucciotti
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000627:therapeutic use*; D002130:Calcium Phosphates / Q000627:therapeutic use*; D005269:Femur / Q000000981:diagnostic imaging / Q000254:growth & development / Q000473:pathology / Q000601:surgery; D066298:In Vitro Techniques; D008422:Materials Testing / Q000379:methods*; D011817:Rabbits; D011859:Radiography; D055114:X-Ray Microtomography
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D002130:Calcium Phosphates; C485817:beta-tricalcium phosphate