title: Triterpenoids from the branch and leaf of Abies fargesii.
abstract: Eighteen triterpenoids, abifarines A-R, including fourteen previously unknown and four artifacts, together with six known ones, were isolated from the branch and leaf of Abies fargesii. Their structures were elucidated by spectroscopic data analysis. The relative configurations of abifarines A and F were further confirmed by single-crystal X-ray diffraction analysis with Mo Kα irradiation. All compounds were evaluated for their in vitro cytotoxicity against the mouse cancer B16 cell line, and human cancer HepG2 and MCF7 cell lines. (24R)-cycloartane-3β,24,25-triol and (24R)-cycloartane-3β,24,25,28-tetrol showed moderate anti-proliferative effect for B16 and HepG2 cell lines with IC50 values of 32.9, 19.5 μM and 26.4, 21.5 μM, respectively.
authors.affiliation: Faculty of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Hangkonglu 13, Wuhan 430030, People's Republic of China.
authors.forename: Wenming
authors.initials: W
authors.lastname: Wu
authors.affiliation: Faculty of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Hangkonglu 13, Wuhan 430030, People's Republic of China.
authors.forename: Xu
authors.initials: X
authors.lastname: Chen
authors.affiliation: Faculty of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Hangkonglu 13, Wuhan 430030, People's Republic of China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Faculty of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Hangkonglu 13, Wuhan 430030, People's Republic of China.
authors.forename: Yanmei
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Faculty of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Hangkonglu 13, Wuhan 430030, People's Republic of China.
authors.forename: Tian
authors.initials: T
authors.lastname: Tian
authors.affiliation: Hubei Entry-Exit Inspection and Quarantine Bureau of the PRC, Wuhan 430050, People's Republic of China.
authors.forename: Xiaoya
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Pharmacy, Tongji Hospital Affiliated Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.affiliation: Faculty of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Hangkonglu 13, Wuhan 430030, People's Republic of China. Electronic address: ruanhl@mails.tjmu.edu.cn.
authors.forename: Hanli
authors.initials: H
authors.lastname: Ruan
mesh_terms: D028202:Abies / Q000737:chemistry; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D056945:Hep G2 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D051379:Mice; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry*; D018515:Plant Leaves / Q000187:drug effects; D013237:Stereoisomerism; D014315:Triterpenes
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D014315:Triterpenes; C085352:cycloartane
keywords: Abies fargesii; Cytotoxicity; Pinaceae; Single-crystal X-ray diffraction; Triterpenoids