title: Structural commonality of C1q TNF-related proteins and their potential to activate relaxin/insulin-like family peptide receptor 1 signalling pathways in cancer cells.
abstract: We established the role of the GPCR relaxin/insulin-like family peptide receptor 1 (RXFP1 receptor) as a novel active receptor in human glioblastoma (GB), a fatal brain tumour. We identified C1q/TNF-related protein 8 (CTRP8) as a novel agonist of the RXFP1 receptor. CTRP8 enhanced the motility and matrix invasion of GB, and this involved PKC-mediated up-regulation of cathepsin B, a marker for poor prognosis in GB patients. We conclude that the absence of relaxin isoforms does not preclude the activation of the RXFP1 receptor, as the least known member of the CTRP family, CTRP8, can effectively target and activate RXFP1 receptors.
  
  
  
  This article is part of a themed section on Recent Progress in the Understanding of Relaxin Family Peptides and their Receptors. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.10/issuetoc.
authors.affiliation: Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, MB, Canada.|Department of Surgery, University of Manitoba, Winnipeg, MB, Canada.|Department of Medical Microbiology & Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada.
authors.forename: Thomas
authors.initials: T
authors.lastname: Klonisch
authors.affiliation: Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, MB, Canada.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Glogowska
authors.affiliation: Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, MB, Canada.
authors.forename: Thatchawan
authors.initials: T
authors.lastname: Thanasupawat
authors.affiliation: Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, MB, Canada.
authors.forename: Maxwell
authors.initials: M
authors.lastname: Burg
authors.affiliation: Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, MB, Canada.|Department of Surgery, University of Manitoba, Winnipeg, MB, Canada.
authors.forename: Jerry
authors.initials: J
authors.lastname: Krcek
authors.affiliation: Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada.
authors.forename: Marshall
authors.initials: M
authors.lastname: Pitz
authors.affiliation: Department of Oral Biology, University of Manitoba, Winnipeg, MB, Canada.
authors.forename: Appalaraju
authors.initials: A
authors.lastname: Jaggupilli
authors.affiliation: Department of Oral Biology, University of Manitoba, Winnipeg, MB, Canada.
authors.forename: Prashen
authors.initials: P
authors.lastname: Chelikani
authors.affiliation: Department of Physiology and Center for Metabolism and Obesity Research, Johns Hopkins School of Medicine, Baltimore, MD, USA.
authors.forename: G William
authors.initials: GW
authors.lastname: Wong
authors.affiliation: Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, MB, Canada.|Department of Obstetrics, Gynecology & Reproductive Medicine, Faculty of Health Sciences, College of Medicine, University of Manitoba, Winnipeg, MB, Canada.
authors.forename: Sabine
authors.initials: S
authors.lastname: Hombach-Klonisch
mesh_terms: D052242:Adiponectin / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D011487:Protein Conformation; D043562:Receptors, G-Protein-Coupled / Q000819:agonists / Q000378:metabolism*; D018000:Receptors, Peptide / Q000819:agonists / Q000378:metabolism*; D012065:Relaxin / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D052242:Adiponectin; C543616:C1QTNF8 protein, human; C417543:RXFP1 protein, human; D043562:Receptors, G-Protein-Coupled; D018000:Receptors, Peptide; D012065:Relaxin