title: Validation of an Argentine version of Lupus Quality of Life questionnaire.
abstract: OBJECTIVE
  To determine reproducibility and validity of an Argentine version of the Lupus Quality of Life questionnaire (LupusQoL) and to determine cut-off values in the questionnaire.
  
  
  METHODS
  One hundred and forty-seven systemic lupus erythematosus patients (American College of Rheumatology 1982/1997) were assessed from April 2014 to July 2014. Demographic and socioeconomic variables were collected, as well as SELENA/SLEDAI, Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index Score, comorbidities and treatment data. Patients completed LupusQoL-Argentine version and European Quality of Life Questionnaire (EuroQoL-5D). Internal consistency and reliability were examined. Convergent validity with EuroQoL-5D was assessed through analysis of latent classes, which established homogeneous categories from the responses of each domain of LupusQoL and for the total.
  
  
  RESULTS
  Out of 147 patients, 93.2% were female, mean age 36.4 ± 11.1 years, mean disease duration 2.7 ± 9 years, mean SELENA/SLEDAI 2.7 ± 3 points. The cut-off point that defined good or bad quality of life was 0.739 for EuroQoL 5D and 63 for LupusQoL. Cut-off values for each LupusQoL domain were also defined, creating two classes in each of them. There was moderate to high concordance to classify quality of life (Kappa = 0.74, 95% confidence interval = 0.54, 0.95).
  
  
  CONCLUSIONS
  The Argentine version of LupusQoL is a valid, reliable and reproducible instrument to assess quality of life. In this study, cut-off points that allow the classification of patients regarding whether they have good or bad quality of life are established for the first time.
authors.affiliation: Hospital Ángel Cruz Padilla, Tucumán, Argentina machadoescobar@hotmail.com.
authors.forename: M A
authors.initials: MA
authors.lastname: Machado Escobar
authors.affiliation: Hospital Ángel Cruz Padilla, Tucumán, Argentina.
authors.forename: M S
authors.initials: MS
authors.lastname: Yacuzzi
authors.affiliation: Hospital Ángel Cruz Padilla, Tucumán, Argentina.
authors.forename: R N
authors.initials: RN
authors.lastname: Martinez
authors.affiliation: Hospital Ángel Cruz Padilla, Tucumán, Argentina.
authors.forename: L
authors.initials: L
authors.lastname: González Lucero
authors.affiliation: Hospital Ángel Cruz Padilla, Tucumán, Argentina.
authors.forename: V I
authors.initials: VI
authors.lastname: Bellomio
authors.affiliation: Hospital Ángel Cruz Padilla, Tucumán, Argentina.
authors.forename: M
authors.initials: M
authors.lastname: Santana
authors.affiliation: Hospital Ángel Cruz Padilla, Tucumán, Argentina.
authors.forename: L
authors.initials: L
authors.lastname: Galindo
authors.affiliation: Hospital Británico de Buenos Aires, Argentina.
authors.forename: M M
authors.initials: MM
authors.lastname: Mayer
authors.affiliation: Hospital Británico de Buenos Aires, Argentina.
authors.forename: J C
authors.initials: JC
authors.lastname: Barreira
authors.affiliation: Instituto Lanari, Buenos Aires, Argentina.
authors.forename: J
authors.initials: J
authors.lastname: Sarano
authors.affiliation: Instituto Lanari, Buenos Aires, Argentina.
authors.forename: G
authors.initials: G
authors.lastname: Gomez
authors.affiliation: Instituto Lanari, Buenos Aires, Argentina.
authors.forename: M V
authors.initials: MV
authors.lastname: Collado
authors.affiliation: Hospital de Agudos Dr E Tornú, Buenos Aires, Argentina.
authors.forename: A
authors.initials: A
authors.lastname: Martinez
authors.affiliation: Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina.
authors.forename: M C
authors.initials: MC
authors.lastname: Orozco
authors.affiliation: Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina.
authors.forename: G
authors.initials: G
authors.lastname: Betancur
authors.affiliation: Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina.
authors.forename: F
authors.initials: F
authors.lastname: Dal Pra
authors.affiliation: Salta, Argentina.
authors.forename: A
authors.initials: A
authors.lastname: Sanchez
authors.affiliation: Salta, Argentina.
authors.forename: V
authors.initials: V
authors.lastname: Juarez
authors.affiliation: Hospital Ángel Cruz Padilla, Tucumán, Argentina.
authors.forename: E V
authors.initials: EV
authors.lastname: Lucero
mesh_terms: D000328:Adult; D001118:Argentina; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007802:Language; D008180:Lupus Erythematosus, Systemic / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012372:ROC Curve; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires / Q000592:standards*; D014175:Translating
keywords: LupusQoL; Systemic lupus erythematosus; quality of life