title: Factors predicting successful discontinuation of continuous renal replacement therapy.
abstract: This multicentre, retrospective observational study was conducted from January 2010 to December 2010 to determine the optimal time for discontinuing continuous renal replacement therapy (CRRT) by evaluating factors predictive of successful discontinuation in patients with acute kidney injury. Analysis was performed for patients after CRRT was discontinued because of renal function recovery. Patients were divided into two groups according to the success or failure of CRRT discontinuation. In multivariate logistic regression analysis, urine output at discontinuation, creatinine level and CRRT duration were found to be significant variables (area under the receiver operating characteristic curve for urine output, 0.814). In conclusion, we found that higher urine output, lower creatinine and shorter CRRT duration were significant factors to predict successful discontinuation of CRRT.
authors.affiliation: MD, Intensive Care, Tokyo Women's Medical University, Department of Emergency Medicine, Asahi General Hospital, Chiba, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Katayama
authors.affiliation: MD, Intensive Care Unit, Department of Anesthesiology, Jikei University School of Medicine, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Uchino
authors.affiliation: MD, Intensive Care Unit, Osaka University Hospital, Osaka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Uji
authors.affiliation: MD, Intensive Care Unit, Department of Anesthesiology, Saitama Medical Center, Jichi Medical University, Saitama, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ohnuma
authors.affiliation: MD, Department of Emergency and Critical Care, Showa University Fujigaoka Hospital, Kanagawa, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Namba
authors.affiliation: MD, Department of Nephrology and Hypertension, St. Marianna University School of Medicine, Kanagawa, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kawarazaki
authors.affiliation: MD, Department of Internal Medicine, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Toki
authors.affiliation: MD, Division of Intensive Care Medicine, Hyogo College of Medicine, Hyogo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Takeda
authors.affiliation: MD, Intensive Care Unit, Department of Emergency and Critical Care Medicine, Japanese Red Cross Musashino Hospital, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Yasuda
authors.affiliation: MD, Intensive Care Unit, Department of Anesthesiology, Jikei University School of Medicine, Tokyo, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Izawa
authors.affiliation: MD, Division of Intensive Care, University Hospital, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Tokuhira
authors.affiliation: MD, Department of Emergency, Kanto Rosai Hospital, Kanagawa, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Nagata
mesh_terms: D058186:Acute Kidney Injury / Q000628:therapy*; D000368:Aged; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D017582:Renal Replacement Therapy; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D003404:Creatinine
keywords: acute kidney injury; continuous renal replacement therapy; creatinine level; urine output