title: Non-infectious thrombosis of the melody®valve: A tale of two cities.
abstract: Bioprosthetic valve thrombosis is an uncommon complication. We report two young women with prior uncomplicated percutaneous pulmonary valve replacement (Melody®, Medtronic, Inc. Minneapolis, MN) who later developed symptomatic pulmonary emboli and pulmonary valve dysfunction without evidence of infection. Thrombophilia risk factors included oral contraceptive use and mild thrombophilia. Both experienced recovery of valve function following anticoagulation. Acute changes in Melody®valve function should prompt a thorough investigation for and treatment of potential thrombotic causes. © 2016 Wiley Periodicals, Inc.
authors.affiliation: Division of Pediatric Cardiology, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota.
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Schneider
authors.affiliation: Division of Pediatric Cardiology, Department of Pediatrics, University of Nebraska, Children's Hospital and Medical Center, Omaha, Nebraska.
authors.forename: Jeffrey W
authors.initials: JW
authors.lastname: Delaney
authors.affiliation: Division of Pediatric Cardiology, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota. cabalka.allison@mayo.edu.|Division of Cardiovascular Diseases, Department of Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota. cabalka.allison@mayo.edu.
authors.forename: Allison K
authors.initials: AK
authors.lastname: Cabalka
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D001705:Bioprosthesis; D006328:Cardiac Catheterization / Q000009:adverse effects* / Q000295:instrumentation* / Q000379:methods; D015150:Echocardiography, Doppler; D005260:Female; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects* / Q000295:instrumentation* / Q000379:methods; D006439:Hemodynamics; D006801:Humans; D011474:Prosthesis Design; D011655:Pulmonary Embolism / Q000209:etiology; D011664:Pulmonary Valve / Q000000981:diagnostic imaging / Q000503:physiopathology; D011666:Pulmonary Valve Stenosis / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D020127:Recovery of Function; D013927:Thrombosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000925:Anticoagulants
keywords: bioprosthetic valve thrombosis; factor V Leiden; pulmonary embolism; thrombophilia; thrombosis