title: Orthodontic treatment of a patient with cleidocranial dysplasia: A case report.
abstract: Cleidocranial dysplasia (CCD) is a rare autosomal dominant condition that affects ossification. The dental abnormalities associated with CCD present an obstacle to orthodontic treatment planning. Early diagnosis is crucial to provide the patient with different treatment modalities that will suit the particular patient. In the present case, combined surgical and orthodontic treatment were performed to guide multiple impacted teeth. A single nucleotide missense variation was identified in exon 3 of runt-related transcription factor 2 (RUNX2) in this patient. The current results suggest a correlation between dental alterations and mutations in the runt domain ofRUNX2in CCD patients. Further clinical and genetic studies may required to confirm the association between phenotypes and genotypes in CCD and to identify other factors that may influence the clinical features of this disease. Patients with cleidocranial dysplasia require a team approach which demands good communication and cooperation from the patient. Timing of the intervention is critical, and numerous surgeries may be required. The patient in the present case report was treated by a team of practitioners, which involved several dental specialties to achieve an optimal result.
authors.affiliation: Department of Orthodontics, Dental and Stomatologic Clinic, Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116023, P.R. China.
authors.forename: Zi-Jian
authors.initials: ZJ
authors.lastname: Li
authors.affiliation: Department of Stomatology, China Medical University, Shenyang, Liaoning 110001, P.R. China.
authors.forename: Jun-Yan
authors.initials: JY
authors.lastname: Wang
authors.affiliation: Department of Orthodontics, Dental and Stomatologic Clinic, Fushun Central Hospital, Fushun, Liaoning 113006, P.R. China.
authors.forename: Ming-Fei
authors.initials: MF
authors.lastname: Gao
authors.affiliation: Department of Orthodontics, Dental and Stomatologic Clinic, Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116023, P.R. China.
authors.forename: Da-Lei
authors.initials: DL
authors.lastname: Wu
authors.affiliation: Department of Orthodontics, Dental and Stomatologic Clinic, Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116023, P.R. China.
authors.forename: Xin
authors.initials: X
authors.lastname: Chang
keywords: RUNX2 mutation; cleidocranial dysplasia; supernumerary teeth