title: A Simple Scoring System Predicting the Survival Time of Patients with Bone Metastases after RT.
abstract: OBJECTIVE
  This study aimed to develop a scoring system to predict the survival time of patients with bone metastases after radiation therapy (RT). The scoring system can guide physicians to a better selection of appropriate treatment regimens.
  
  
  METHODS
  The medical records of 125 patients with bone metastases treated with RT between January 2007 and September 2010 were reviewed retrospectively. Fifteen potential prognostic factors were investigated: sex, age, Karnofsky performance score (KPS), type of primary tumor, resection of tumor before bone metastases, interval between primary tumor diagnosis and diagnosis of bone metastases, Carcinoembryonic Antigen(CEA), lung metastases before bone metastases, liver metastases before bone metastases, brain metastases before bone metastases, stage, T, N, M, and degree of cellular differentiation.
  
  
  RESULTS
  In an univariate analysis, 10 factors were significantly associated with survival time after bone metastasis: sex, KPS, breast cancer, esophageal cancer, colorectal cancer, interval between tumor diagnosis and diagnosis of bone metastases, CEA, lung metastases before bone metastases, T-staging, and differentiation. In a multivariate analysis, 7 factors were found to be significant: sex, KPS, esophageal cancer, colorectal cancer, interval between tumor diagnosis and diagnosis of bone metastases, T-staging, and differentiation. The median survival of all patients with bone metastases after RT was 14.1 months. There were significant differences in the median survival of patients with bone metastases after RT of 4.9 months, 10.5 months, and 29.7 months in groups 1, 2, and 3, respectively (P<0.001).
  
  
  CONCLUSIONS
  According to this scoring system, the survival time of patients after bone metastasis can be estimated.
authors.affiliation: Department of Radiotherapy and Chemotherapy, The First Affiliated Hospital of Wenzhou Medical University, WenZhou, China.
authors.forename: Wen-Yi
authors.initials: WY
authors.lastname: Zhang
authors.affiliation: Department of Radiotherapy and Chemotherapy, The First Affiliated Hospital of Wenzhou Medical University, WenZhou, China.
authors.forename: Hui-Fang
authors.initials: HF
authors.lastname: Li
authors.affiliation: Department of Radiotherapy and Chemotherapy, The First Affiliated Hospital of Wenzhou Medical University, WenZhou, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Su
authors.affiliation: Department of Radiotherapy and Chemotherapy, The First Affiliated Hospital of Wenzhou Medical University, WenZhou, China.
authors.forename: Rui-Fang
authors.initials: RF
authors.lastname: Lin
authors.affiliation: Department of Radiotherapy and Chemotherapy, The First Affiliated Hospital of Wenzhou Medical University, WenZhou, China.
authors.forename: Xing-Xing
authors.initials: XX
authors.lastname: Chen
authors.affiliation: Department of Radiotherapy and Chemotherapy, The First Affiliated Hospital of Wenzhou Medical University, WenZhou, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Radiotherapy and Chemotherapy, The First Affiliated Hospital of Wenzhou Medical University, WenZhou, China.
authors.forename: Chang-Lin
authors.initials: CL
authors.lastname: Zou
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000532:radiotherapy* / Q000556:secondary; D001932:Brain Neoplasms / Q000473:pathology / Q000532:radiotherapy; D001943:Breast Neoplasms / Q000473:pathology / Q000532:radiotherapy; D015179:Colorectal Neoplasms / Q000473:pathology / Q000532:radiotherapy; D004938:Esophageal Neoplasms / Q000473:pathology / Q000532:radiotherapy; D005260:Female; D006801:Humans; D017567:Karnofsky Performance Status; D008113:Liver Neoplasms / Q000473:pathology / Q000532:radiotherapy; D008175:Lung Neoplasms / Q000473:pathology / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors; D016019:Survival Analysis