title: Diagnostic Power of Vascular Endothelial Growth Factor and Macrophage Colony-Stimulating Factor in Breast Cancer Patients Based on ROC Analysis.
abstract: Breast cancer (BC) is the most common malignancy in women. Vascular endothelial growth factor (VEGF) has been described as an important regulator of angiogenesis which plays a vital role in the progression of tumor. Macrophage colony-stimulating factor (M-CSF) is a cytokine whose functions include regulation of hematopoietic lineages cells growth, proliferation, and differentiation. We investigated the diagnostic significance of these parameters in comparison to CA15-3 in BC patients and in relation to the control group (benign breast tumor and healthy women). Plasma levels of the tested parameters were determined by ELISA and CA15-3 was determined by CMIA. VEGF was shown to be comparable to CA15-3 values of sensitivity in BC group and, what is more important, higher values in early stages of BC. VEGF was also the only parameter which has statistically significant AUC in all stages of cancer. M-CSF has been shown to be comparable to CA15-3 and VEGF, specificity, and AUC values only in stages III and IV of BC. These results indicate the usefulness and high diagnostic power of VEGF in the detection of BC. Also, it occurred to be the best candidate for cancer diagnostics in stages I and II of BC and in the differentiation between BC and benign cases.
authors.affiliation: Department of Biochemical Diagnostics, Medical University of Bialystok, 15-089 Bialystok, Poland.
authors.forename: Monika
authors.identifier: 0000-0002-5179-0722
authors.initials: M
authors.lastname: Zajkowska
authors.affiliation: Department of Esthetic Medicine, Medical University of Bialystok, 15-089 Bialystok, Poland.
authors.forename: Edyta Katarzyna
authors.initials: EK
authors.lastname: Głażewska
authors.affiliation: Department of Hematological Diagnostics, Medical University of Bialystok, 15-089 Bialystok, Poland.
authors.forename: Grażyna Ewa
authors.initials: GE
authors.lastname: Będkowska
authors.affiliation: Department of Surgery, Public Health Hospital, 19-100 Monki, Poland.
authors.forename: Przemysław
authors.initials: P
authors.lastname: Chorąży
authors.affiliation: Department of Biochemical Diagnostics, Medical University of Bialystok, 15-089 Bialystok, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Szmitkowski
authors.affiliation: Department of Biochemical Diagnostics, Medical University of Bialystok, 15-089 Bialystok, Poland.
authors.forename: Sławomir
authors.initials: S
authors.lastname: Ławicki
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000097:blood* / Q000175:diagnosis* / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016173:Macrophage Colony-Stimulating Factor / Q000097:blood*; D008875:Middle Aged; D012372:ROC Curve; D012680:Sensitivity and Specificity; D035602:Transcriptional Elongation Factors / Q000097:blood; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*
chemical_list: C108440:TCERG1 protein, human; D035602:Transcriptional Elongation Factors; D042461:Vascular Endothelial Growth Factor A; D016173:Macrophage Colony-Stimulating Factor