title: Neoatherosclerosis after Drug-Eluting Stent Implantation: Roles and Mechanisms.
abstract: In-stent neoatherosclerosis (NA), characterized by a relatively thin fibrous cap and large volume of yellow-lipid accumulation after drug-eluting stents (DES) implantation, has attracted much attention owing to its close relationship with late complications, such as revascularization and late stent thrombosis (ST). Accumulating evidence has demonstrated that more than one-third of patients with first-generation DES present with NA. Even in the advent of second-generation DES, NA still occurs. It is indicated that endothelial dysfunction induced by DES plays a critical role in neoatherosclerotic development. Upregulation of reactive oxygen species (ROS) induced by DES implantation significantly affects endothelial cells healing and functioning, therefore rendering NA formation. In light of the role of ROS in suppression of endothelial healing, combining antioxidant therapies with stenting technology may facilitate reestablishing a functioning endothelium to improve clinical outcome for patients with stenting.
authors.affiliation: Cardiovascular Diseases Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China; China Heart Institute of Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100091, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Cui
authors.affiliation: Cardiovascular Diseases Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China; China Heart Institute of Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100091, China.
authors.forename: Yue
authors.identifier: 0000-0002-0084-863X
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Cardiovascular Diseases Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China; China Heart Institute of Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100091, China.
authors.forename: Fuhai
authors.identifier: 0000-0002-1380-170X
authors.initials: F
authors.lastname: Zhao
authors.affiliation: Cardiovascular Diseases Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China; China Heart Institute of Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100091, China.
authors.forename: Dazhuo
authors.initials: D
authors.lastname: Shi
authors.affiliation: Cardiovascular Diseases Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China; China Heart Institute of Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100091, China.
authors.forename: Keji
authors.initials: K
authors.lastname: Chen