title: Endoscopic Observation of the Growth Process of a Right-Side Sessile Serrated Adenoma/Polyp with Cytological Dysplasia to an Invasive Submucosal Adenocarcinoma.
abstract: A sessile serrated adenoma/polyp (SSA/P) with cytological dysplasia in the right colon, which transformed to an invasive submucosal adenocarcinoma finally, was endoscopically observed in a 76-year-old woman. A whitish soft SSA/P (approximately 25 mm in diameter) was detected in the cecum. Biopsy samples were obtained from the small nodule, and the lesion was eventually diagnosed as an SSA/P with cytological dysplasia, considering endoscopic observations, among which the narrow-band imaging features suggested that the lesion was adenomatous, that is, a round-oval pattern, and hyperplastic, that is, comprising a circular pattern with dots and an invisible capillary vessel. After 11 months, an SSA/P had rapidly developed into a submucosal adenocarcinoma with lymphatic infiltrations, and the most aggressive deep invasion was observed in the central depression. This case suggests that right-side SSA/Ps with cytological dysplasia should be removed immediately, considering the potential for rapid progression to a larger size and eventually to deep and extensive cancer.
authors.affiliation: Department of Gastroenterology and Hepatology, Sato Daiichi Hospital, 77-1 Hokyoji, Usa, Oita 879-0454, Japan.
authors.forename: Kaoru
authors.identifier: 0000-0001-6874-4952
authors.initials: K
authors.lastname: Omori
authors.affiliation: Department of Gastroenterology and Hepatology, Sato Daiichi Hospital, 77-1 Hokyoji, Usa, Oita 879-0454, Japan.
authors.forename: Kanako
authors.initials: K
authors.lastname: Yoshida
authors.affiliation: Department of Pathology, Kitakyushu Medical Center, 2-1-1 Bashaku, Kitakyushu, Fukuoka 802-0077, Japan.
authors.forename: Sadafumi
authors.identifier: 0000-0003-1073-4000
authors.initials: S
authors.lastname: Tamiya
authors.affiliation: Department of Pathology, Graduate School of Medicine, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Yufu, Oita 879-5593, Japan.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Daa
authors.affiliation: Department of Gastroenterology and Hepatology, Sato Daiichi Hospital, 77-1 Hokyoji, Usa, Oita 879-0454, Japan.
authors.forename: Masahiro
authors.identifier: 0000-0001-5906-9182
authors.initials: M
authors.lastname: Kan