title: Cholesteryl ester transfer protein (CETP) I405V polymorphism and cardiovascular disease in eastern European Caucasians - a cross-sectional study.
abstract: The cholesteryl ester transfer protein (CETP) polymorphism I405V has been suggested to be involved in longevity and susceptibility to cardiovascular diseases. An enhanced reverse cholesterol transport due to enhanced HDL levels has been hypothesized to be the underlying mechanism. However, clinical trials with HDL-enhancing drugs failed to show beneficial effects. Consequently, it has been postulated that genetic variations enhancing HDL levels are cardioprotective only if they also decrease LDL levels.
  
  
  
  A cross-sectional study was conducted to genotype 1028 healthy blood donors and 1517 clinically well characterized elderly for CETP I405V.
  
  
  
  We could not find any association of this polymorphism with age for both, males or females, in any of these cohorts (P = 0.71 and P = 0.57, respectively, for males and P = 0.55 and P = 0.88, respectively, for females). In addition, no association with cardiovascular diseases could be observed in the elderly cohort (males OR = 1.12 and females OR = 0.88). In the same cohort, the CETP V405V genotype was associated with significantly enhanced HDL levels (P = 0.03), mostly owing to the female sex (P = 0.46 for males, P = 0.02 for females), whereas LDL and triglyceride levels were unchanged (P = 0.62 and P = 0.18, respectively).
  
  
  
  Our data support the recent hypothesis that variations enhancing HDL levels without affecting LDL levels are not associated with the risk for cardiovascular diseases.
authors.affiliation: Institute of Microbiology and Hygiene, Charité University Medical Center Berlin, Rahel-Hirsch-Weg 3, 10117, Berlin, Germany.
authors.forename: Jasmin
authors.initials: J
authors.lastname: Bustami
authors.affiliation: Institute of Microbiology and Hygiene, Charité University Medical Center Berlin, Rahel-Hirsch-Weg 3, 10117, Berlin, Germany.|Research Institute of Epidemiology, MOH, Yerevan, Armenia.
authors.forename: Anna
authors.initials: A
authors.lastname: Sukiasyan
authors.affiliation: Department of Gastro-enterology, Lithuanian University of Health Sciences, Kaunas, Lithuania.|Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Juozas
authors.initials: J
authors.lastname: Kupcinskas
authors.affiliation: Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Jurgita
authors.initials: J
authors.lastname: Skieceviciene
authors.affiliation: Cellecta Inc, Mountain View, California, USA.
authors.forename: Leonid
authors.initials: L
authors.lastname: Iakoubov
authors.affiliation: Department of Human Epigenetics, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Szwed
authors.affiliation: Institute of Microbiology and Hygiene, Charité University Medical Center Berlin, Rahel-Hirsch-Weg 3, 10117, Berlin, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Kleinle
authors.affiliation: Institute of Microbiology and Hygiene, Charité University Medical Center Berlin, Rahel-Hirsch-Weg 3, 10117, Berlin, Germany.
authors.forename: Ralf R
authors.initials: RR
authors.lastname: Schumann
authors.affiliation: Department of Human Epigenetics, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.|Department of Geriatrics and Gerontology, Medical Centre of Postgraduate Education, Warsaw, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Puzianowska-Kuznicka
authors.affiliation: Institute of Microbiology and Hygiene, Charité University Medical Center Berlin, Rahel-Hirsch-Weg 3, 10117, Berlin, Germany. lutz.hamann@charite.de.
authors.forename: Lutz
authors.initials: L
authors.lastname: Hamann
mesh_terms: D000368:Aged; D002318:Cardiovascular Diseases / Q000208:ethnology / Q000235:genetics; D053480:Cholesterol Ester Transfer Proteins / Q000235:genetics*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D044465:White People / Q000235:genetics
chemical_list: C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins; D008075:Lipoproteins, HDL
keywords: Cardio vascular disease; Cholesteryl ester transfer protein; Genetic polymorphism; High-density lipoprotein; Single nucleotide polymorphism