title: Effect of Single Administration of Coffee on Pupil Size and Ocular Wavefront Aberration Measurements in Healthy Subjects.
abstract: No study has so far evaluated the impact of coffee drinking on ocular wavefront aberration (OWA) measurements. This study presents novel findings regarding the OWA of the eye following coffee intake. We aimed to evaluate the acute changes in pupil size and OWA of the eye after single administration of coffee. A total of 30 otherwise healthy participants were included in this prospective study. All subjects drank a cup of coffee containing 57 mg caffeine. Measurements of pupil size, total coma (TC), total trefoil (TF), total spherical aberration (TSA), and total higher order aberration (HOA) were performed before and at 5 minutes, at 30 minutes, and at 4 hours after coffee drinking using a wavefront aberrometer device (Irx3, Imagine Eyes, Orsay, France). The mean age of the study population was 20.30 ± 2.74 years. Pupil size did not show a significant change during the measurements (p > 0.05). A significant increase was observed in TF and HOA measurements following coffee intake (p = 0.029 and p = 0.009, resp.). Single administration of coffee results in significant increase in TF and total HOAs in healthy subjects without any effect on pupil diameter. Ultrastructural changes in the cornea following coffee intake might be of relevance to the alterations in ocular aberrations in healthy subjects.
authors.affiliation: Department of Ophthalmology, Haydarpasa Numune Training and Research Hospital, Uskudar, 34668 Istanbul, Turkey.
authors.forename: Handan
authors.initials: H
authors.lastname: Bardak
authors.affiliation: Department of Ophthalmology, Zeynep Kamil Maternity and Children's Disease Training and Research Hospital, Uskudar, 34668 Istanbul, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Gunay
authors.affiliation: Department of Ophthalmology, Haydarpasa Numune Training and Research Hospital, Uskudar, 34668 Istanbul, Turkey.
authors.forename: Ugur
authors.initials: U
authors.lastname: Mumcu
authors.affiliation: Department of Ophthalmology, Haydarpasa Numune Training and Research Hospital, Uskudar, 34668 Istanbul, Turkey.
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Bardak
mesh_terms: D000284:Administration, Oral; D000869:Anterior Eye Segment / Q000033:anatomy & histology / Q000187:drug effects* / Q000503:physiopathology*; D002110:Caffeine / Q000008:administration & dosage*; D003069:Coffee / Q000737:chemistry*; D019781:Corneal Topography; D004305:Dose-Response Relationship, Drug; D015877:Miosis; D015878:Mydriasis; D011680:Pupil / Q000187:drug effects / Q000502:physiology*; D012016:Reference Values
chemical_list: D003069:Coffee; D002110:Caffeine