title: [Non-metastatic triple-negative breast cancer in 2016: Definitions and management].
abstract: Triple-negative breast cancer (TN), as defined by the triple negativity in immunohistochemistry: the absence of estrogen receptor, progesterone receptor and the absence of overexpression or amplification of HER2, corresponds to 15 % of invasive breast cancers. This is a very heterogeneous group of tumors both at the genomic and transcriptomic level and at morphological, clinical and prognostic level. Although there are some good prognosis forms, the majority of TN tumors is characterized by a poor prognosis with a greater frequency of visceral metastases and a maximum risk of relapse in the first two years after diagnosis. Systemic adjuvant treatment with chemotherapy is almost always indicated. The surgical treatment and radiotherapy treatment should be comparable to the other subtypes and obey the same rules of oncologic surgery. TN tumors are not associated with a higher risk of locoregional relapse after conservative treatment and adjuvant radiotherapy. Optimization of systemic therapies is currently and for the last decade a challenge. A number of targeted therapies and efficiency biomarkers identification of these targeted therapies is essential to allow significant progress in optimizing systemic therapy for these tumors.
authors.affiliation: Département de chirurgie oncologique, centre de lutte contre le cancer Georges-François-Leclerc (CGFL), Unicancer, 1, rue du Professeur-Marion, 21000 Dijon, France.
authors.forename: H
authors.initials: H
authors.lastname: Portha
authors.affiliation: Département de chirurgie oncologique, centre de lutte contre le cancer Georges-François-Leclerc (CGFL), Unicancer, 1, rue du Professeur-Marion, 21000 Dijon, France; UFR des sciences de santé, université de Bourgogne, 7, boulevard Jeanne-d'Arc, 21000 Dijon, France.
authors.forename: C
authors.initials: C
authors.lastname: Jankowski
authors.affiliation: Département de chirurgie oncologique, centre de lutte contre le cancer Georges-François-Leclerc (CGFL), Unicancer, 1, rue du Professeur-Marion, 21000 Dijon, France.
authors.forename: M
authors.initials: M
authors.lastname: Cortet
authors.affiliation: Département d'oncologie médicale, CGFL, Unicancer, 1, rue du Professeur-Marion, 21000 Dijon, France.
authors.forename: I
authors.initials: I
authors.lastname: Desmoulins
authors.affiliation: Département de radiothérapie, CGFL, Unicancer, 1, rue du Professeur-Marion, 21000 Dijon, France.
authors.forename: E
authors.initials: E
authors.lastname: Martin
authors.affiliation: Département d'oncologie médicale, CGFL, Unicancer, 1, rue du Professeur-Marion, 21000 Dijon, France.
authors.forename: V
authors.initials: V
authors.lastname: Lorgis
authors.affiliation: Département de biologie et de pathologie des tumeurs, CGFL, Unicancer, 1, rue du Professeur-Marion, 21000 Dijon, France.
authors.forename: L
authors.initials: L
authors.lastname: Arnould
authors.affiliation: Département de chirurgie oncologique, centre de lutte contre le cancer Georges-François-Leclerc (CGFL), Unicancer, 1, rue du Professeur-Marion, 21000 Dijon, France; UFR des sciences de santé, université de Bourgogne, 7, boulevard Jeanne-d'Arc, 21000 Dijon, France. Electronic address: ccoutant@cgfl.fr.
authors.forename: C
authors.initials: C
authors.lastname: Coutant
mesh_terms: D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D013514:Surgical Procedures, Operative; D064726:Triple Negative Breast Neoplasms / Q000737:chemistry / Q000473:pathology / Q000628:therapy*
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone
keywords: Adjuvant systemic therapies; Cancer du sein triple-négatif; Locoregional treatments; Prognostic; Pronostic; Traitement adjuvant; Traitement locorégional; Triple-negative breast cancer