title: The Cost of Postoperative Pancreatic Fistula Versus the Cost of Pasireotide: Results from a Prospective Randomized Trial.
abstract: The objective of this study was to determine the costs of clinically significant postoperative pancreatic fistula (POPF) and to evaluate the cost-effectiveness of routine pasireotide use.
  
  
  
  We recently completed a prospective randomized trial that demonstrated an 11.7% absolute risk reduction of clinically significant POPF with use of perioperative pasireotide in patients undergoing pancreaticoduodenectomy or distal pancreatectomy [POPF: pasireotide (n = 152), 9% vs placebo (n = 148), 21%; P = 0.006].
  
  
  
  An institutional modeling system was utilized to obtain total direct cost estimates from the 300 patients included in the trial. This system identified direct costs of hospitalization, physician fees, laboratory tests, invasive procedures, outpatient encounters, and readmissions. Total direct costs were calculated from the index admission to 90 days after resection. Costs were converted to Medicare proportional dollars (MP$).
  
  
  
  Clinically significant POPF occurred in 45 of the 300 randomized patients (15%). The mean total cost for all patients was MP$23,400 (MP$8,000 - MP$202,500). The mean cost for those who developed clinically significant POPF was MP$39,700 (MP$13,800 - MP$202,500) versus MP$20,500 (MP$8,000 - MP$62,900) for those who did not (P = 0.001). The mean cost of pasireotide within the treatment group (n = 152) was MP$3,300 (MP$300 - MP$3,800). The mean cost was lower in the pasireotide (n = 152) group than the placebo (n = 148) group; however, this did not reach statistical significance (pasireotide, MP$22,800 vs placebo, MP$23,900: P = 0.571).
  
  
  
  The development of POPF nearly doubled the total cost of pancreatic resection. In this randomized trial, the routine use of pasireotide significantly reduced the occurrence of POPF without increasing the overall cost of care.
authors.affiliation: *Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY †Center of Health Policy and Outcomes, Memorial Sloan Kettering Cancer Center, New York, NY ‡Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY.
authors.forename: Linda W
authors.initials: LW
authors.lastname: Ma
authors.forename: Ismael
authors.initials: I
authors.lastname: Dominguez-Rosado
authors.forename: Renee L
authors.initials: RL
authors.lastname: Gennarelli
authors.forename: Peter B
authors.initials: PB
authors.lastname: Bach
authors.forename: Mithat
authors.initials: M
authors.lastname: Gonen
authors.forename: Michael I
authors.initials: MI
authors.lastname: D'Angelica
authors.forename: Ronald P
authors.initials: RP
authors.lastname: DeMatteo
authors.forename: T Peter
authors.initials: TP
authors.lastname: Kingham
authors.forename: Murray F
authors.initials: MF
authors.lastname: Brennan
authors.forename: William R
authors.initials: WR
authors.lastname: Jarnagin
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Allen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003362:Cost-Benefit Analysis; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D017048:Health Care Costs / Q000706:statistics & numerical data; D006728:Hormones / Q000191:economics* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D018803:Models, Economic; D009519:New York City; D010180:Pancreatectomy; D010185:Pancreatic Fistula / Q000191:economics* / Q000209:etiology / Q000517:prevention & control; D016577:Pancreaticoduodenectomy; D011183:Postoperative Complications / Q000191:economics* / Q000517:prevention & control; D011446:Prospective Studies; D013004:Somatostatin / Q000031:analogs & derivatives* / Q000191:economics / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D006728:Hormones; D013004:Somatostatin; C517782:pasireotide