title: Setting the Stage for Notch: The Drosophila Su(H)-Hairless Repressor Complex.
abstract: Notch signaling is iteratively used throughout development to maintain stem cell potential or in other instances allow differentiation. The central transcription factor in Notch signaling is CBF-1/RBP-J, Su(H), Lag-1 (CSL)-Su(H) in Drosophila-which functions as a molecular switch between transcriptional activation and repression. Su(H) represses transcription by forming a complex with the corepressor Hairless (H). The Su(H)-repressor complex not only competes with the Notch intracellular domain (NICD) but also configures the local chromatin landscape. In this issue, Yuan and colleagues determined the structure of the Su(H)/H complex, showing that a major conformational change within Su(H) explains why the binding of NICD and H is mutually exclusive.
authors.affiliation: Institute of Biochemistry, University of Giessen, Giessen, Germany.
authors.forename: Tilman
authors.initials: T
authors.lastname: Borggrefe
authors.affiliation: Center for Internal Medicine, Department of Internal Medicine I, University Medical Center Ulm, Ulm, Germany.
authors.forename: Franz
authors.initials: F
authors.lastname: Oswald
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins; D004330:Drosophila; D029721:Drosophila Proteins / Q000737:chemistry*; D008565:Membrane Proteins; D051880:Receptors, Notch / Q000737:chemistry; D012097:Repressor Proteins / Q000737:chemistry; D015398:Signal Transduction; D014157:Transcription Factors / Q000737:chemistry
chemical_list: D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D008565:Membrane Proteins; D051880:Receptors, Notch; D012097:Repressor Proteins; D014157:Transcription Factors