title: Meningioma Genomics: Diagnostic, Prognostic, and Therapeutic Applications.
abstract: There has been a recent revolution in our understanding of the genetic factors that drive meningioma, punctuating an equilibrium that has existed since Cushing's germinal studies nearly a century ago. A growing appreciation that meningiomas share similar biologic features with other malignancies has allowed extrapolation of management strategies and lessons from intra-axial central nervous system neoplasms and systemic cancers to meningiomas. These features include a natural proclivity for invasion, frequent intratumoral heterogeneity, and correlation between biologic profile and clinical behavior. Next-generation sequencing has characterized recurrent somatic mutations in NF2, TRAF7, KLF4, AKT1, SMO, and PIK3CA, which are collectively present in ~80% of sporadic meningiomas. Genomic features of meningioma further associate with tumor location, histologic subtype, and possibly clinical behavior. Such genomic decryption, along with advances in targeted pharmacotherapy, provides a maturing integrated view of meningiomas. We review recent advances in meningioma genomics and probe their potential applications in diagnostic, therapeutic, and prognostic frontiers.
authors.affiliation: Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School , Boston, MA , USA.
authors.forename: Wenya Linda
authors.initials: WL
authors.lastname: Bi
authors.affiliation: Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School , Boston, MA , USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School , Boston, MA , USA.
authors.forename: Winona W
authors.initials: WW
authors.lastname: Wu
authors.affiliation: Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School , Boston, MA , USA.
authors.forename: Yu
authors.initials: Y
authors.lastname: Mei
authors.affiliation: Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School , Boston, MA , USA.
authors.forename: Ian F
authors.initials: IF
authors.lastname: Dunn
keywords: genomics; meningioma; molecular taxonomy; precision medicine; targeted therapy