title: Soluble E-cadherin as a serum biomarker in patients with HBV-related liver diseases.
abstract: OBJECTIVE
  Substantial evidence indicates that serum sE-cadherin is a pivotal regulator that contributes to the initiation and development of various types of diseases. However, very little is known about the relationship between levels of serum sE-cadherin and HBV-related disorders. The overall goal of the study is to get a better insight into whether or not serum sE-cadherin is involved in HBV-related diseases.
  
  
  METHODS
  Serum levels of sE-cadherin and IFN-γ, from 113 patients with chronic hepatitis B, 101 patients with HBV-related cirrhosis, 75 patients with hepatocellular carcinoma and 125 healthy individuals were measured with commercial available sandwich ELISA kits.
  
  
  RESULTS
  sE-cadherin values were significantly higher in patients compared to healthy control (p<0.0001). The levels of serum sE-cadherin were significantly positively correlated with the serum levels of IFN-γ, alanine transaminase and aspartate aminotransferase in chronic hepatitis B and cirrhosis patients. In hepatocellular carcinoma patients, serum sE-cadherin concentrations were only significantly positively correlated with the serum levels of ALT and AST.
  
  
  CONCLUSIONS
  Serum sE-cadherin levels maybe an important indicator of the pathogenesis of progression of HBV-related disorders.
authors.affiliation: Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
authors.forename: Jingyi
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Laboratory Medicine, The Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Xiong
authors.affiliation: Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yan
authors.affiliation: Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Sun
authors.affiliation: Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Duan
authors.affiliation: Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
authors.forename: Pu
authors.initials: P
authors.lastname: Li
authors.affiliation: Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China. Electronic address: chenweixian75@163.com.
authors.forename: Weixian
authors.initials: W
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood*; D015820:Cadherins / Q000097:blood*; D005260:Female; D006509:Hepatitis B / Q000097:blood*; D006515:Hepatitis B virus / Q000472:pathogenicity*; D006801:Humans; D007371:Interferon-gamma / Q000097:blood; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D015415:Biomarkers; D015820:Cadherins; D007371:Interferon-gamma
keywords: Chronic hepatitis B; Cirrhosis; Cytokine; Hepatitis B virus; Hepatocellular carcinoma; sE-cadherin