title: The Correlation Between the Serum Squamous Carcinoma Antigen and the Prognosis of Recurrent Cervical Squamous Carcinoma.
abstract: BACKGROUND
  To explore the relationship of the serum squamous cell carcinoma antigen (SCC-Ag) with the pathologic characteristics, occurrence, and prognosis of cervical squamous carcinoma.
  
  
  METHODS
  The enzyme-linked immunosorbent assay (ELISA) method was used to determine the serum SCC-Ag levels for the patients, which included 424 pretreatment patients and 500 cases after treatment.
  
  
  RESULTS
  (a) Pretreatment SCC-Ag levels of patients were related to clinical stages, lymphatic metastasis, and myometrial invasion, (b) within a median follow-up of 54 months, 180 recurrences (36%) and 102 disease-associated deaths (20.4%) were recorded, 161 recurrent patients showed elevated SCC-Ag levels (161/180, 89.4%), and 60 of them (37.3%) had a significant increase in SCC-Ag serum levels before clinical manifestation of relapse. The lead time ranged between 1 and 5 months (median: 2.3 months). The total survival rates were 23.4% and 17.8% for 3-year and 5-year period, respectively, and (c) clinical stages, the site of recurrence, and SCC-Ag levels after treatment were closely related with recurrent patients' survival time (P < 0.01~<0.005). Multivariate analysis indicated that the clinical stages and SCC-Ag levels of recurrent patients were independent prognostic factors (P < 0.05˜0.01).
  
  
  CONCLUSIONS
  Serum SCC-Ag level was an important predictor for the cervical squamous carcinoma recurrence and prognosis.
authors.affiliation: Department of Tumor Markers and Etiology Detection, Shanxi Cancer Hospital, Taiyuan, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Radiation Therapy, Shanxi Cancer Hospital, Taiyuan, China.
authors.forename: Tong
authors.initials: T
authors.lastname: Cui
authors.affiliation: Department of Tumor Markers and Etiology Detection, Shanxi Cancer Hospital, Taiyuan, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Du
authors.affiliation: Department of Tumor Markers and Etiology Detection, Shanxi Cancer Hospital, Taiyuan, China.
authors.forename: Xiaoqin
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Tumor Markers and Etiology Detection, Shanxi Cancer Hospital, Taiyuan, China.
authors.forename: Baoguo
authors.initials: B
authors.lastname: Tian
authors.affiliation: Department of Tumor Markers and Etiology Detection, Shanxi Cancer Hospital, Taiyuan, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Sun
authors.affiliation: Department of Tumor Markers and Etiology Detection, Shanxi Cancer Hospital, Taiyuan, China.
authors.forename: Cunzhi
authors.initials: C
authors.lastname: Han
authors.affiliation: Department of Tumor Markers and Etiology Detection, Shanxi Cancer Hospital, Taiyuan, China.
authors.forename: Xianwen
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Tumor Markers and Etiology Detection, Shanxi Cancer Hospital, Taiyuan, China.
authors.forename: Jiexian
authors.initials: J
authors.lastname: Jing
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000097:blood*; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D011379:Prognosis; D012307:Risk Factors; D015843:Serpins / Q000097:blood*; D016019:Survival Analysis; D002583:Uterine Cervical Neoplasms / Q000097:blood* / Q000473:pathology; D055815:Young Adult
chemical_list: D000951:Antigens, Neoplasm; D015843:Serpins; C051072:squamous cell carcinoma-related antigen
keywords: cervical carcinoma; prognosis; squamous cell carcinoma antigen; tumor recurrence