title: Effect of Dexmedetomidine on Normal Coronary Vessel Diameter.
abstract: Dexmedetomidine is a selective alpha2 agonist, which is widely used for conscious sedation in ICU patients. It is being increasingly used to provide conscious sedation in out-of-theatre procedures like CT scan, MRI, endoscopies and catheterization (cath) procedures. There is limited data till date regarding the effect of dexmedetomidine on coronary vessel diameter. The aim of this prospective observational study was to observe the effect of dexmedetomidine on normal coronary vessel diameter. Fifty patients who had come for elective coronary angiography in the cath lab were enrolled in the study. After taking the first shot of the coronary angiogram and confirming that the right coronary artery (RCA) is normal, dexmedetomidine was administered in a dose of 1 µg/kg intravenously over 15 min. Immediately after that, another shot was taken to check the diameter of RCA. Paired Student's t test was used to analyze the data. The mean diameter of RCA before giving dexmedetomidine was 2.7634 ± 0.3189 mm. The mean diameter decreased significantly to 2.6296 ± 0.3379 mm after administration of dexmedetomidine (p value <0.0001). Thus, dexmedetomidine decreases the coronary vessel diameter.
authors.affiliation: Department of Anaesthesia, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bangalore, India.
authors.forename: Tanveer Singh
authors.initials: TS
authors.lastname: Kundra
authors.forename: Parminder
authors.initials: P
authors.lastname: Kaur
mesh_terms: D017023:Coronary Angiography / Q000379:methods; D003331:Coronary Vessels / Q000000981:diagnostic imaging* / Q000187:drug effects*; D020927:Dexmedetomidine / Q000008:administration & dosage*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage; D007262:Infusions, Intravenous; D011446:Prospective Studies; D014661:Vasoconstriction / Q000187:drug effects* / Q000502:physiology
chemical_list: D006993:Hypnotics and Sedatives; D020927:Dexmedetomidine