title: An association analysis of lipid profile and diabetic cardiovascular autonomic neuropathy in a Chinese sample.
abstract: BACKGROUND
  Recent studies have shown that triglyceride (TG), low-density lipoprotein cholesterol (LDL), and high-density lipoprotein cholesterol (HDL) are related to the prevalence of cardiovascular autonomic neuropathy (CAN). However, little is known about the association of lipid profile with diabetic cardiovascular autonomic neuropathy (DCAN), or its severity in the Chinese population. The purpose of this study is to explore the extent of this phenomenon using a Chinese sample.
  
  
  METHODS
  A subgroup analysis on 455 diabetic patients with undiagnosed DCAN was performed to evaluate the relationships of lipids profile and DCAN. DCAN was diagnosed if there were at least two abnormal cardiovascular autonomic reflex test results, based on short-term heart rate variability tests. Multivariable logistic regression (MLR)was carried out to control potential confounders for determining the independent association of variables with DCAN in different models.
  
  
  RESULTS
  MLR analysis indicated that TG was significantly and independently associated with DCAN when controlling for confounding factors (P < 0.1 for two models). Additionally, TG combined with TC (LRS-1) and LDL (LRS-2) was associated with this outcome (P < 0.1 for LRS-1 and LRS-2).
  
  
  CONCLUSIONS
  Our findings indicate that TG and the severity of lipids profile is significantly and independently associated with DCAN, respectively.
  
  
  BACKGROUND
  ClinicalTrials.gov Identifier: NCT02461472 , retrospectively registered 2 Jun, 2015.
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China.
authors.forename: Lige
authors.initials: L
authors.lastname: Song
authors.affiliation: Department of Endocrinology and Metabolism, Fudan University Huashan Hospital, Shanghai, China.
authors.forename: Linuo
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China. dr_zhtang@yeah.net.
authors.forename: Zihui
authors.initials: Z
authors.lastname: Tang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D003929:Diabetic Neuropathies / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D005260:Female; D006339:Heart Rate; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D014280:Triglycerides / Q000097:blood*
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides
keywords: Association; Chinese sample; Diabetic cardiac autonomic neuropathy; Lipid profile