title: [Improvement in zinc nutrition due to zinc transporter-targeting strategy].
abstract: Adequate intake of zinc from the daily diet is indispensable to maintain health. However, the dietary zinc content often fails to fulfill the recommended daily intake, leading to zinc deficiency and also increases the risk of developing chronic diseases, particularly in elderly individuals. Therefore, increased attention is required to overcome zinc deficiency and it is important to improve zinc nutrition in daily life. In the small intestine, the zinc transporter, ZIP4, functions as a component that is essential for zinc absorption. In this manuscript, we present a brief overview regarding zinc deficiency. Moreover, we review a novel strategy, called "ZIP4-targeting", which has the potential to enable efficient zinc absorption from the diet. ZIP4-targeting strategy is possibly a major step in preventing zinc deficiency and improving human health.
authors.forename: Taiho
authors.initials: T
authors.lastname: Kambe
mesh_terms: D000169:Acrodermatitis / Q000209:etiology / Q000378:metabolism; D000818:Animals; D027682:Cation Transport Proteins / Q000378:metabolism*; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D009752:Nutritional Status; D015032:Zinc / Q000172:deficiency / Q000378:metabolism*
chemical_list: D027682:Cation Transport Proteins; D015032:Zinc