title: With mouse age comes wisdom: A review and suggestions of relevant mouse models for age-related conditions.
abstract: Ageing is a complex multifactorial process that results in many changes in physiological changes processes that ultimately increase susceptibility to a wide range of diseases. As such an ageing population is resulting in a pressing need for more and improved treatments across an assortment of diseases. Such treatments can come from a better understanding of the pathogenic pathways which, in turn, can be derived from models of disease. Therefore the more closely the model resembles the disease situation the more likely relevant the data will be that is generated from them. Here we review the state of knowledge of mouse models of a range of diseases and aspects of an ageing physiology that are all germane to ageing. We also give recommendations on the most common mouse models on their relevance to the clinical situations occurring in aged patients and look forward as to how research in ageing models can be carried out. As we continue to elucidate the pathophysiology of disease, often through mouse models, we also learn what is needed to refine these models. Such factors can include better models, reflecting the ageing patient population, or a better phenotypic understanding of existing models.
authors.affiliation: Ludwig Botlzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria.
authors.forename: Susanne
authors.initials: S
authors.lastname: Drechsler
authors.affiliation: Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland.
authors.forename: Marina A
authors.initials: MA
authors.lastname: Lynch
authors.affiliation: Department of Physiology, Universitat de València, València, Spain; Institute of Health Research-INCLIVA, 46010 València, Spain.
authors.forename: Susana
authors.initials: S
authors.lastname: Novella
authors.affiliation: Institute of Health Research-INCLIVA, 46010 València, Spain; The Research Institute for Medicines (iMed.ULisboa) and Faculty of Pharmacy, University of Lisbon, 1649-003 Lisbon, Portugal.
authors.forename: Herminia
authors.initials: H
authors.lastname: González-Navarro
authors.affiliation: Laboratory of Molecular Neuropharmacology, Division of Molecular Medicine, Rudjer Boskovic Institute, Croatia.
authors.forename: Silva
authors.initials: S
authors.lastname: Hecimovic
authors.affiliation: Neurobehavioural Genetics Group, NBT - IIT, Genova, Italy.
authors.forename: Erica
authors.initials: E
authors.lastname: Barini
authors.affiliation: Neurobehavioural Genetics Group, NBT - IIT, Genova, Italy.
authors.forename: Valter
authors.initials: V
authors.lastname: Tucci
authors.affiliation: The Research Institute for Medicines (iMed.ULisboa) and Faculty of Pharmacy, University of Lisbon, 1649-003 Lisbon, Portugal.
authors.forename: Rui E
authors.initials: RE
authors.lastname: Castro
authors.affiliation: Inflammation Research Center, VIB, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
authors.forename: Roosmarijn E
authors.initials: RE
authors.lastname: Vandenbroucke
authors.affiliation: Ludwig Botlzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria.
authors.forename: Marcin
authors.initials: M
authors.lastname: Osuchowski
authors.affiliation: Mammalian Genetics Unit, MRC Harwell, Oxfordshire, UK. Electronic address: p.potter@har.mrc.ac.uk.
authors.forename: Paul K
authors.initials: PK
authors.lastname: Potter
mesh_terms: D000375:Aging / Q000378:metabolism* / Q000473:pathology*; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice
keywords: Ageing; Mouse models; Phenotyping