title: The Proteomics of Saliva in Sjögren's Syndrome.
abstract: One of the main characteristics of primary Sjögren's syndrome (pSS) is chronic dysfunction and destruction of the salivary and lacrimal glands; their secretory biofluids should reflect the glandular biological status. Saliva is a heterogeneous biofluid comprised of biomolecules and omics constituents that are altered in response to various diseases. Scientific effort has evaluated saliva proteome to diagnose, monitor, and prognosticate pSS. This article reviews the recent advances in salivary proteomics in the context of pSS, highlighting the most significant and promising findings. Determining saliva as a credible means of early disease detection could lead to translational advantages and significant clinical opportunities for pSS.
authors.affiliation: Center for Oral/Head and Neck Oncology Research, Division of Oral Biology, School of Dentistry, UCLA, 10833 Le Conte Avenue, CHS 73-034, Los Angeles, CA 90095, USA.
authors.forename: Stergios
authors.initials: S
authors.lastname: Katsiougiannis
authors.affiliation: Center for Oral/Head and Neck Oncology Research, Division of Oral Biology, School of Dentistry, UCLA, 10833 Le Conte Avenue, CHS 73-034, Los Angeles, CA 90095, USA. Electronic address: dtww@ucla.edu.
authors.forename: David T W
authors.initials: DT
authors.lastname: Wong
mesh_terms: D000974:Antibodies, Antinuclear / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology*; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D011379:Prognosis; D040901:Proteomics; D012463:Saliva / Q000276:immunology* / Q000378:metabolism; D012859:Sjogren's Syndrome / Q000175:diagnosis / Q000276:immunology* / Q000378:metabolism
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D016207:Cytokines; C035356:SS-A antibodies; C035357:SS-B antibodies
keywords: Biomarkers; Proteomics; Saliva; Saliva diagnostics; Sjögren's syndrome