title: Chemical Constituents from the Stems of Daphne holosericea (Diels) Hamaya.
abstract: Two new compounds, one flavanol dimer dapholosericol A (1) and one tigliane diterpene dapholosericin A (2), together with ten known ones, were isolated from the AcOEt extract of Daphne holosericea (Diels) Hamaya. Their structures were elucidated by their spectroscopic data analysis. Compounds 1 and 2 showed moderate activities against acetylcholinesterase with inhibition ratio of 36% and 29% at a concentration of 100 μmol/l, respectively.
authors.affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, P. R. China.
authors.forename: Qing-Yun
authors.initials: QY
authors.lastname: Ma
authors.affiliation: College of Forestry, Southwest Forestry University, Kunming, 650224, P. R. China.
authors.forename: Yi-Chun
authors.initials: YC
authors.lastname: Chen
authors.affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, P. R. China.
authors.forename: Sheng-Zhuo
authors.initials: SZ
authors.lastname: Huang
authors.affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, P. R. China.
authors.forename: Fan-Dong
authors.initials: FD
authors.lastname: Kong
authors.affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, P. R. China.
authors.forename: Li-Man
authors.initials: LM
authors.lastname: Zhou
authors.affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, P. R. China.
authors.forename: Hao-Fu
authors.initials: HF
authors.lastname: Dai
authors.affiliation: College of Forestry, Southwest Forestry University, Kunming, 650224, P. R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Hua
authors.affiliation: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, P. R. China.
authors.forename: You-Xing
authors.initials: YX
authors.lastname: Zhao
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D032364:Daphne / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D002800:Cholinesterase Inhibitors; D004224:Diterpenes; D005419:Flavonoids; C000613433:dapholosericin A; C000613432:dapholosericol A; D000110:Acetylcholinesterase
keywords: 
  Daphne holosericea
  ; AChE inhibition; Dapholosericin A; Dapholosericol A; Thymelaeaceae