title: Angioscopic comparison of arterial repair after second-generation drug-eluting stent implantation into vulnerable and stable coronary plaques.
abstract: BACKGROUND
  Arterial repair after intracoronary stenting depends on stent types and plaque vulnerability. The aim of this study was angioscopic comparison of arterial repair after implantation of the second-generation drug-eluting stents (G2-DES) between the stable and vulnerable plaques.
  
  
  METHODS
  Four types of G2-DES were successfully implanted into stable plaques (n=41) and vulnerable plaques (n=34): 13 and 9 Xience-everolimus-, 7 and 6 Endeavor-zotarolimus-, 15 and 9 Resolute-zotarolimus-, and 6 and 10 Nobori-biolimus-eluting stents (EES, E-ZES, R-ZES, and BES), respectively. Coronary angioscopy at 1-year follow-up revealed in-stent appearance, such as neointimal stent coverage (NSC), presence of yellow plaques (YP), and in-stent mural thrombus (MT). NSC was graded into poor and good coverage.
  
  
  RESULTS
  Yellow plaques and mural thrombi were found more frequently in the vulnerable plaques than in the stable plaques (29% vs. 12%, P=0.06; 12 vs. 0%, P=0.02; respectively). In EES, poor NSC was observed more frequently in the vulnerable plaques than in the stable plaques (54% vs. 11%, P=0.04). In BES, YP was observed more frequently in the vulnerable plaques than in the stable plaques (80% vs. 17%, P=0.01). In E-ZES and R-ZES, there were no significant differences with regards to angioscopic parameters between the stable and vulnerable plaques.
  
  
  CONCLUSIONS
  Arterial repair after EES and BES implantation into the vulnerable plaques remained vulnerable even at 1-year follow-up.
authors.affiliation: Department of Cardiology, Higahi-osaka City General Hospital, 3-4-5 Nishi Iwata, Higashi-osaka, Osaka 578-8588, Japan; Division of Cardiovascular Medicine and Coronary Heart Disease, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Kawai
authors.affiliation: Department of Cardiology, Higahi-osaka City General Hospital, 3-4-5 Nishi Iwata, Higashi-osaka, Osaka 578-8588, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Ichikawa
authors.affiliation: Division of Cardiovascular Medicine and Coronary Heart Disease, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan.
authors.forename: Tohru
authors.initials: T
authors.lastname: Masuyama
authors.affiliation: Department of Cardiology, Higahi-osaka City General Hospital, 3-4-5 Nishi Iwata, Higashi-osaka, Osaka 578-8588, Japan. Electronic address: y-kijima@ichou.med.osaka-u.ac.jp.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Kijima
mesh_terms: D000368:Aged; D017023:Coronary Angiography / Q000639:trends; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000628:therapy*; D054855:Drug-Eluting Stents / Q000639:trends; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D058226:Plaque, Atherosclerotic / Q000000981:diagnostic imaging* / Q000628:therapy*
keywords: Arterial repair; Coronary angioscopy; Drug-eluting stent