title: Identification of PARP-Specific ADP-Ribosylation Targets Reveals a Regulatory Function for ADP-Ribosylation in Transcription Elongation.
abstract: In a recent issue of Science, Gibson et al. (2016) describe an in vitro chemical genetic approach that maps the specific ADP-ribosylation sites targeted by the ADP-ribosyltransferases PARP-1, PARP-2, and PARP-3 and demonstrate that PARP-1 regulates RNA polymerase II promoter-proximal pausing.
authors.affiliation: Department of Molecular Mechanisms of Disease, University of Zurich, 8057 Zurich, Switzerland; Molecular Life Science PhD Program of the Life Science Zurich Graduate School, 8057 Zurich, Switzerland.
authors.forename: Mario
authors.initials: M
authors.lastname: Leutert
authors.affiliation: Department of Molecular Mechanisms of Disease, University of Zurich, 8057 Zurich, Switzerland.
authors.forename: Deena M Leslie
authors.initials: DML
authors.lastname: Pedrioli
authors.affiliation: Department of Molecular Mechanisms of Disease, University of Zurich, 8057 Zurich, Switzerland. Electronic address: michael.hottiger@dmmd.uzh.ch.
authors.forename: Michael O
authors.initials: MO
authors.lastname: Hottiger
mesh_terms: D000244:Adenosine Diphosphate; D006031:Glycosylation; D000071137:Poly (ADP-Ribose) Polymerase-1; D011065:Poly(ADP-ribose) Polymerases / Q000235:genetics*; D012319:RNA Polymerase II
chemical_list: D000244:Adenosine Diphosphate; D000071137:Poly (ADP-Ribose) Polymerase-1; D011065:Poly(ADP-ribose) Polymerases; D012319:RNA Polymerase II