title: Current Perspectives on Arthroplasty in Systemic Lupus Erythematosus: Rates, Outcomes, and Adverse Events.
abstract: Systemic lupus erythematosus (SLE) is a chronic debilitating condition with significant impact on the musculoskeletal system. Arthroplasty may be indicated for damage related to active lupus or its treatment. As therapies for SLE have advanced, morbidity and mortality have declined, while the rate of joint replacement has increased. The age of SLE patients undergoing arthroplasty is increasing, and the indication for surgery is evolving-while avascular necrosis was previously the predominant indication for arthroplasty, osteoarthritis now accounts for a larger proportion of surgeries. Pain and functional outcomes of arthroplasty in SLE patients are comparable to those of the general population with osteoarthritis, but lupus remains an independent risk factor for post-hip arthroplasty complications and mortality. Further research is needed to characterize the impact of lupus disease activity and severity on arthroplasty outcomes.
authors.affiliation: Division of Rheumatology, Department of Medicine, Hospital for Special Surgery, 535 East 70th Street, New York, NY, 10021, USA. kasturis@hss.edu.
authors.forename: Shanthini
authors.initials: S
authors.lastname: Kasturi
authors.affiliation: Division of Rheumatology, Department of Medicine, Hospital for Special Surgery, 535 East 70th Street, New York, NY, 10021, USA.
authors.forename: Susan
authors.initials: S
authors.lastname: Goodman
mesh_terms: D019643:Arthroplasty, Replacement / Q000009:adverse effects*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D010003:Osteoarthritis / Q000209:etiology* / Q000601:surgery*; D010020:Osteonecrosis / Q000209:etiology / Q000601:surgery; D012307:Risk Factors; D016896:Treatment Outcome
keywords: Arthroplasty; Epidemiology; Joint replacement; Outcomes; Systemic lupus erythematosus