title: Concentrations of omentin and vaspin versus insulin resistance in obese individuals.
abstract: BACKGROUND
  Omentin and vaspin are adipokines manifesting a potentially protective action against obesity-associated metabolic disturbances.
  
  
  OBJECTIVE
  Evaluation of relationship between serum concentrations of omentin and vaspin on one hand and indices of insulin resistance and anthropometric parameters in obese individuals on the other.
  
  
  METHODS
  The studies were conducted on 64 individuals. The investigated group (37 obese patients) included the subgroup with normal glucose tolerance (NGT) and with abnormal glucose tolerance (AGT). The control group (n=27) included healthy individuals with normal body weight. In all participants anthropometric analyses and biochemical tests, including estimation of omentin and vaspin concentrations were performed, and insulin resistance by HOMA-IR was evaluated.
  
  
  RESULTS
  Concentrations of examined adipokines manifested no significant differences between the examined groups. Median values of the index defining ratio between studied adipokine and degree of insulin resistance, i.e. omentin/HOMA-IR, proved to be different in the investigated and the control group while no such difference could be noted in cases of vaspin/HOMA-IR indices. In the studied population a negative relationship was detected between serum concentration of omentin and systolic blood pressure (p<0.04). Values of omentin/HOMA-IR index manifested a correlation with values of most anthropometric parameters (p<0.0001), blood pressure (p<0.0001) concentrations of TG (p<000.1) and HDL (p<0.0001), ISIbasal(p<0.00001), ISIgly(p<0.0001), Quicki (p<0.00001) and fasting insulinaemia (p<0.00001). In the case of vaspin/HOMA-IR index only its positive relationship with HDL concentration was noted (p<0.05).
  
  
  CONCLUSIONS
  In context of date of correlation, multiple regression and values of area of under receiver operating characteristics curve omentin, as compared to vaspin, seems to provide a better predictor of insulin resistance in obese individuals.
authors.affiliation: Division of Biology of Civilization-Related Diseases, Poznan University of Medical Sciences, Poznan, Poland. Electronic address: msperling@ump.edu.pl.
authors.forename: Marcelina
authors.initials: M
authors.lastname: Sperling
authors.affiliation: Division of Biology of Civilization-Related Diseases, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Teresa
authors.initials: T
authors.lastname: Grzelak
authors.affiliation: Division of Biology of Civilization-Related Diseases, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Pelczyńska
authors.affiliation: Division of Biology of Civilization-Related Diseases, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Paula
authors.initials: P
authors.lastname: Jasinska
authors.affiliation: Department of Education and Obesity Treatment and Metabolic Disorders, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Pawel
authors.initials: P
authors.lastname: Bogdanski
authors.affiliation: Department of Internal Medicine, Metabolic Disorders and Hypertension, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Danuta
authors.initials: D
authors.lastname: Pupek-Musialik
authors.affiliation: Division of Biology of Civilization-Related Diseases, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Krystyna
authors.initials: K
authors.lastname: Czyzewska
mesh_terms: D000328:Adult; D000886:Anthropometry; D016022:Case-Control Studies; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D058851:GPI-Linked Proteins / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance; D037102:Lectins / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism*; D012372:ROC Curve; D015843:Serpins / Q000378:metabolism*
chemical_list: D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins; C507339:SERPINA12 protein, human; D015843:Serpins
keywords: Insulin resistance; Obesity; Omentin; Vaspin