title: Modulating the Nucleated Self-Assembly of Tri-β(3) -Peptides Using Cucurbit[n]urils.
abstract: The modulation of the hierarchical nucleated self-assembly of tri-β(3) -peptides has been studied. β(3) -Tyrosine provided a handle to control the assembly process through host-guest interactions with CB[7] and CB[8]. By varying the cavity size from CB[7] to CB[8] distinct phases of assembling tri-β(3) -peptides were arrested. Given the limited size of the CB[7] cavity, only one aromatic β(3) -tyrosine can be simultaneously hosted and, hence, CB[7] was primarily acting as an inhibitor of self-assembly. In strong contrast, the larger CB[8] can form a ternary complex with two aromatic amino acids and hence CB[8] was acting primarily as cross-linker of multiple fibers and promoting the formation of larger aggregates. General insights on modulating supramolecular assembly can lead to new ways to introduce functionality in supramolecular polymers.
authors.affiliation: Molecular Nanofabrication Group of the MESA+, Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500AE, Enschede, Netherlands.|Bioinspired Molecular Engineering Laboratory of the MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, P.O. Box 217, 7500AE, Enschede, Netherlands.
authors.forename: Tushar
authors.initials: T
authors.lastname: Satav
authors.affiliation: Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, Netherlands.
authors.forename: Peter
authors.initials: P
authors.lastname: Korevaar
authors.affiliation: Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, Netherlands.
authors.forename: Tom F A
authors.initials: TF
authors.lastname: de Greef
authors.affiliation: Molecular Nanofabrication Group of the MESA+, Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500AE, Enschede, Netherlands. j.huskens@utwente.nl.
authors.forename: Jurriaan
authors.initials: J
authors.lastname: Huskens
authors.affiliation: Molecular Nanofabrication Group of the MESA+, Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500AE, Enschede, Netherlands. p.jonkheijm@utwente.nl.|Bioinspired Molecular Engineering Laboratory of the MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, P.O. Box 217, 7500AE, Enschede, Netherlands. p.jonkheijm@utwente.nl.
authors.forename: Pascal
authors.initials: P
authors.lastname: Jonkheijm
mesh_terms: D001952:Bridged-Ring Compounds / Q000737:chemistry*; D007093:Imidazoles / Q000737:chemistry*; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry*
chemical_list: D001952:Bridged-Ring Compounds; D007093:Imidazoles; D010455:Peptides
keywords: cooperativity; cucurbit[n]urils; host-guest systems; self-assembly