title: Pulmonary Hypertension in the Era of Mechanical Circulatory Support.
abstract: Left heart disease (LHD) represents the most common cause of pulmonary hypertension (PH), and is associated with worse prognosis compared with LHD without PH. In addition, PH due to LHD may prevent patients from receiving heart transplantation, because of risk of perioperative right ventricular failure. Current literature lacks comprehensive descriptions and management strategies of PH due to LHD. In this review, we summarize the literature that is available to highlight the definition, pathogenesis, and prognosis of PH due to LHD. Furthermore, we discuss the use of mechanical circulatory support (MCS) in this population. Finally, we provide recommendations regarding the management and reassessment of PH due to LHD in the specific context of MCS.
authors.affiliation: From the Duke Clinical Research Institute, Department of Medicine and Department of Surgery, Duke University Medical Center, Durham, North Carolina.
authors.forename: Yamini
authors.initials: Y
authors.lastname: Krishnamurthy
authors.forename: Lauren B
authors.initials: LB
authors.lastname: Cooper
authors.forename: Kishan S
authors.initials: KS
authors.lastname: Parikh
authors.forename: G Michael
authors.initials: GM
authors.lastname: Felker
authors.forename: Carmelo A
authors.initials: CA
authors.lastname: Milano
authors.forename: Joseph G
authors.initials: JG
authors.lastname: Rogers
authors.forename: Adrian F
authors.initials: AF
authors.lastname: Hernandez
authors.forename: Chetan B
authors.initials: CB
authors.lastname: Patel
mesh_terms: D006331:Heart Diseases / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy