title: MicroRNAs differentially expressed in Behçet disease are involved in interleukin-6 production.
abstract: BACKGROUND
  Behcet's disease (BD) is characterized by systemic recurrent inflammation with increased production of tumor necrosis factor (TNF)-α and interleukin (IL)-6 by peripheral blood mononuclear cells (PBMCs). To gain insight into the underlying mechanisms of this disease, the expression levels of distinct microRNAs in PBMCs of BD patients were determined and their association with TNF-α and IL-6 production was evaluated.
  
  
  RESULTS
  The expression levels of microRNAs, miR-638 and miR-4488, were reduced in patients with stable BD in comparison with healthy controls. In addition, the expression of miR-3591-3p was increased in patients with active BD when compared to patients with stable BD. Transfection of miR-638 and miR-4488 inhibitors, together with miR-3591-3p mimics, increased IL-6 mRNA levels in THP-1 cells in response to LPS stimulation.
  
  
  CONCLUSIONS
  We observed differential expression of microRNAs associated with increased production of IL-6 in BD patients.
authors.affiliation: Department of Microbiology, Ajou University School of Medicine, Youngtongku Wonchondong San 5, Suwon, 442-749 Korea.|Department of Biomedical Sciences, The Graduate School, Ajou University, Youngtongku Wonchondong San 5, Suwon, 442-749 Korea.
authors.forename: Min-Yeong
authors.initials: MY
authors.lastname: Woo
authors.affiliation: Department of Microbiology, Ajou University School of Medicine, Youngtongku Wonchondong San 5, Suwon, 442-749 Korea.|Department of Biomedical Sciences, The Graduate School, Ajou University, Youngtongku Wonchondong San 5, Suwon, 442-749 Korea.
authors.forename: Su Jin
authors.initials: SJ
authors.lastname: Yun
authors.affiliation: Department of Microbiology, Ajou University School of Medicine, Youngtongku Wonchondong San 5, Suwon, 442-749 Korea.|Department of Biomedical Sciences, The Graduate School, Ajou University, Youngtongku Wonchondong San 5, Suwon, 442-749 Korea.
authors.forename: Okki
authors.initials: O
authors.lastname: Cho
authors.affiliation: Department of Microbiology, Ajou University School of Medicine, Youngtongku Wonchondong San 5, Suwon, 442-749 Korea.|Department of Biomedical Sciences, The Graduate School, Ajou University, Youngtongku Wonchondong San 5, Suwon, 442-749 Korea.
authors.forename: Kyongmin
authors.initials: K
authors.lastname: Kim
authors.affiliation: Department of Dermatology, Ajou University School of Medicine, Youngtongku Wonchondong San 5, Suwon, 442-749 Korea.
authors.forename: Eun-So
authors.initials: ES
authors.lastname: Lee
authors.affiliation: Department of Microbiology, Ajou University School of Medicine, Youngtongku Wonchondong San 5, Suwon, 442-749 Korea.|Department of Biomedical Sciences, The Graduate School, Ajou University, Youngtongku Wonchondong San 5, Suwon, 442-749 Korea.
authors.forename: Sun
authors.initials: S
authors.lastname: Park
keywords: Behçet syndrome; Cytokine; Gene expression; Pathogenesis; microRNA