title: Prognostic factors in resected pancreatic neuroendocrine tumours: Experience in 95 patients.
abstract: BACKGROUND
  The aim of this study was to analyze prognostic factors for survival and recurrence in patients with resected pancreatic neuroendocrine tumors (PNT).
  
  
  METHODS
  Medical records of 95 patients with resected PNT were retrospectively reviewed. The variables studied were: age, sex, form of presentation (sporadic/familial tumors), functionality, type of tumor, localization, type of surgery, tumor size, multifocal tumors and recurrent rate. The new WHO classification (2010) was used.
  
  
  RESULTS
  There were 45 men and 50 women. Mean age was 46.8 years. Regarding the mode of presentation, it was sporadic in 66 patients (69.8%) and 29 cases were familial neuroendocrine tumors (30.2%) in association with MEN 1 syndrome. The 59% of patients suffered from non-functional tumors and 41% were functional: 20 insulinoma, 16 gastrinoma, and 3 glucagonoma. Distal pancreatectomy was the most common surgical procedure, followed by tumor enucleation in 19 patients. According to the WHO classification, 59 patients had a PNT G1, 24 PNT G2 and 12 with a poorly-differentiated carcinoma, respectively. The 5-year survival in well-differentiated tumors was 100%, regardless of the functionality. Sporadic PNT are more commonly unifocal (P<0.001), associating liver metastasis. Survival and recurrence rates after a mean follow-up of 85.3 months were 65.8 and 24%, respectively.
  
  
  CONCLUSIONS
  In our experience, WHO classification was an independent prognostic factor in PNT survival.
authors.affiliation: Servicio de Cirugía, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, España. Electronic address: sbuenof@um.es.
authors.forename: Francisco
authors.initials: F
authors.lastname: Sánchez-Bueno
authors.affiliation: Servicio de Cirugía, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, España.
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Rodríguez González
authors.affiliation: Servicio de Cirugía, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, España.
authors.forename: Gloria
authors.initials: G
authors.lastname: Torres Salmerón
authors.affiliation: Servicio de Cirugía, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, España.
authors.forename: Antonio
authors.initials: A
authors.lastname: Bernabé Peñalver
authors.affiliation: Servicio de Cirugía, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, España.
authors.forename: María
authors.initials: M
authors.lastname: Balsalobre Salmeron
authors.affiliation: Servicio de Anatomía Patológica, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, España.
authors.forename: Jesús
authors.initials: J
authors.lastname: de la Peña Moral
authors.affiliation: Servicio de Radiodiagnóstico, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, España.
authors.forename: Matilde
authors.initials: M
authors.lastname: Fuster Quiñonero
authors.affiliation: Servicio de Cirugía, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, España.
authors.forename: Pascual
authors.initials: P
authors.lastname: Parrilla Paricio
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000401:mortality / Q000601:surgery*; D010190:Pancreatic Neoplasms / Q000401:mortality / Q000601:surgery*; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D055815:Young Adult
keywords: Gastrinoma; Gastrinomas; Glucagonoma; Glucagonomas; Insulinoma; Insulinomas; Pancreas; Pancreatic neuroendocrine tumours; Pancreatic resection; Páncreas; Resección pancreática; Tumores neuroendocrinos del páncreas