title: De-escalation of pivotal beta-lactam in ventilator-associated pneumonia does not impact outcome and marginally affects MDR acquisition.
authors.affiliation: Department of Anesthesiology and Critical Care, AP-HP, Hôpital Beaujon, Paris Diderot University, 92110, Clichy, France. emmanuel.weiss@aphp.fr.
authors.forename: E
authors.initials: E
authors.lastname: Weiss
authors.affiliation: Infection Control Unit, Hôpital d'Angers, Angers University, 49000, Angers, France.
authors.forename: J R
authors.initials: JR
authors.lastname: Zahar
authors.affiliation: Intensive Care Unit, Hôpital St Joseph, Paris Descartes University, 75014, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Garrouste-Orgeas
authors.affiliation: Joseph Fourier University, 38041, Saint-Martin-d'Hères, France.
authors.forename: S
authors.initials: S
authors.lastname: Ruckly
authors.affiliation: UMR 1137-IAME Team 5-DeSCID: Decision SCiences in Infectious Diseases, Control and Care Inserm/Univ Paris Diderot, Sorbonne Paris Cité, 75018, Paris, France.
authors.forename: W
authors.initials: W
authors.lastname: Essaied
authors.affiliation: Medical Intensive Care Unit, Hôpital Albert Michallon, Grenoble University, 38043, Grenoble, France.
authors.forename: C
authors.initials: C
authors.lastname: Schwebel
authors.affiliation: UMR 1137-IAME Team 5-DeSCID: Decision SCiences in Infectious Diseases, Control and Care Inserm/Univ Paris Diderot, Sorbonne Paris Cité, 75018, Paris, France.|Medical and Infectious Intensive Care Unit, AP-HP, Hôpital Bichat Claude Bernard, Paris Diderot University, 75018, Paris, France.
authors.forename: J F
authors.initials: JF
authors.lastname: Timsit
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D015780:Carbapenems / Q000627:therapeutic use; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D007362:Intensive Care Units; D053717:Pneumonia, Ventilator-Associated / Q000188:drug therapy* / Q000382:microbiology; D012189:Retrospective Studies; D018440:beta-Lactam Resistance; D047090:beta-Lactams / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D047090:beta-Lactams