title: Simultaneous Polymerization and Polypeptide Particle Production via Reactive Spray-Drying.
abstract: A method for producing polypeptide particles via in situ polymerization of N-carboxyanhydrides during spray-drying has been developed. This method was enabled by the development of a fast and robust synthetic pathway to polypeptides using 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as an initiator for the ring-opening polymerization of N-carboxyanhydrides. The polymerizations finished within 5 s and proved to be very tolerant toward impurities such as amino acid salts and water. The formed particles were prepared by mixing the monomer, N-carboxyanhydride of l-glutamic acid benzyl ester (NCAGlu) and the initiator (DBU) during the atomization process in the spray-dryer and were spherical with a size of ∼1 μm. This method combines two steps; making it a straightforward process that facilitates the production of polypeptide particles. Hence, it furthers the use of spray-drying and polypeptide particles in the pharmaceutical industry.
authors.affiliation: Fiber and Polymer Technology, School of Chemical Science and Engineering, KTH, Royal Institute of Technology , SE-100 44 Stockholm, Sweden.
authors.forename: Lidija
authors.initials: L
authors.lastname: Glavas
authors.affiliation: Fiber and Polymer Technology, School of Chemical Science and Engineering, KTH, Royal Institute of Technology , SE-100 44 Stockholm, Sweden.
authors.forename: Karin
authors.initials: K
authors.lastname: Odelius
authors.affiliation: Fiber and Polymer Technology, School of Chemical Science and Engineering, KTH, Royal Institute of Technology , SE-100 44 Stockholm, Sweden.
authors.forename: Ann-Christine
authors.initials: AC
authors.lastname: Albertsson
mesh_terms: D003890:Desiccation; D018698:Glutamic Acid / Q000737:chemistry*; D046911:Macromolecular Substances / Q000737:chemistry*; D010316:Particle Size; D010455:Peptides / Q000737:chemistry*; D058105:Polymerization; D014867:Water / Q000737:chemistry*
chemical_list: D046911:Macromolecular Substances; D010455:Peptides; D014867:Water; D018698:Glutamic Acid