title: Recent insights into humoral immunity targeting Plasmodium falciparum and Plasmodium vivax malaria.
abstract: Recent efforts in malaria control have led to marked reductions in malaria incidence. However, new strategies are needed to sustain malaria elimination and eradication and achieve the World Health Organization goal of a malaria-free world. The development of highly effective vaccines would contribute to this goal and would be facilitated by a comprehensive understanding of humoral immune responses targeting Plasmodium falciparum and Plasmodium vivax malaria. New tools are required to facilitate the identification of vaccine candidates and the development of vaccines that induce functional and protective immunity. Here we discuss recent published findings, and unpublished work presented at the 2016 Molecular Approaches to Malaria conference, that highlight advancements in understanding humoral immune responses in the context of vaccine development. Highlights include the increased application of 'omics' and 'Big data' platforms to identify vaccine candidates, and the identification of novel functions of antibody responses that mediate protection. The application of these strategies and a global approach will increase the likelihood of rapid development of highly efficacious vaccines.
authors.affiliation: Burnet Institute for Medical Research and Public Health, Melbourne, Victoria 3004, Australia; Menzies School of Medical Research, Darwin, Northern Territory 0810, Australia. Electronic address: mboyle@burnet.edu.au.
authors.forename: Michelle J
authors.initials: MJ
authors.lastname: Boyle
authors.affiliation: Burnet Institute for Medical Research and Public Health, Melbourne, Victoria 3004, Australia.
authors.forename: Linda
authors.initials: L
authors.lastname: Reiling
authors.affiliation: KEMRI Centre for Geographic Medicine Research-Coast, Kilifi, Kenya.
authors.forename: Faith H
authors.initials: FH
authors.lastname: Osier
authors.affiliation: Burnet Institute for Medical Research and Public Health, Melbourne, Victoria 3004, Australia; Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria 3010, Australia; Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria 3004, Australia; Department of Infectious Diseases, Monash University, Melbourne, Victoria 3004, Australia.
authors.forename: Freya J I
authors.initials: FJ
authors.lastname: Fowkes
mesh_terms: D000913:Antibodies, Protozoan; D006801:Humans; D056724:Immunity, Humoral; D017780:Malaria Vaccines; D016778:Malaria, Falciparum / Q000276:immunology*; D016780:Malaria, Vivax / Q000276:immunology* / Q000517:prevention & control
chemical_list: D000913:Antibodies, Protozoan; D017780:Malaria Vaccines
keywords: Complement; Immunity; Malaria; Microarray; Phagocytosis; Plasmodium falciparum; Plasmodium vivax; Vaccine