title: Impact of CDT Toxin on Human Diseases.
abstract: Cytolethal distending toxin (CDT) is found in Gram-negative bacteria, especially in certain Proteobacteria such as the Pasteurellaceae family, including Haemophilus ducreyi and Aggregatibacter (Actinobacillus) actinomycetemcomitans, in the Enterobacteriaceae family and the Campylobacterales order, including the Campylobacter and Helicobacter species. In vitro and in vivo studies have clearly shown that this toxin has a strong effect on cellular physiology (inflammation, immune response modulation, tissue damage). Some works even suggest a potential involvement of CDT in cancers. In this review, we will discuss these different aspects.
authors.affiliation: Microbes, Inflammation, Intestin et Susceptibilit&#233; de l'H&#244;te (M2iSH), Clermont Universit&#233;, Universit&#233; d'Auvergne; INSERM U1071; INRA USC2018, Clermont-Ferrand 63000, France. tfais@chu-clermontferrand.fr.|Laboratoire de Bact&#233;riologie, Centre Hospitalier Universitaire, Clermont-Ferrand 63000, France. tfais@chu-clermontferrand.fr.|Institut Universitaire de Technologie, Universit&#233; d'Auvergne, Aubi&#232;re 63170, France. tfais@chu-clermontferrand.fr.
authors.forename: Tiphanie
authors.initials: T
authors.lastname: Faïs
authors.affiliation: Microbes, Inflammation, Intestin et Susceptibilit&#233; de l'H&#244;te (M2iSH), Clermont Universit&#233;, Universit&#233; d'Auvergne; INSERM U1071; INRA USC2018, Clermont-Ferrand 63000, France. jdelmas@chu-clermontferrand.fr.|Laboratoire de Bact&#233;riologie, Centre Hospitalier Universitaire, Clermont-Ferrand 63000, France. jdelmas@chu-clermontferrand.fr.|Institut Universitaire de Technologie, Universit&#233; d'Auvergne, Aubi&#232;re 63170, France. jdelmas@chu-clermontferrand.fr.
authors.forename: Julien
authors.initials: J
authors.lastname: Delmas
authors.affiliation: Laboratoire de Bact&#233;riologie, Centre Hospitalier Universitaire, Clermont-Ferrand 63000, France. aserres@chu-clermontferrand.fr.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Serres
authors.affiliation: Microbes, Inflammation, Intestin et Susceptibilit&#233; de l'H&#244;te (M2iSH), Clermont Universit&#233;, Universit&#233; d'Auvergne; INSERM U1071; INRA USC2018, Clermont-Ferrand 63000, France. rbonnet@chu-clermontferrand.fr.|Laboratoire de Bact&#233;riologie, Centre Hospitalier Universitaire, Clermont-Ferrand 63000, France. rbonnet@chu-clermontferrand.fr.|Institut Universitaire de Technologie, Universit&#233; d'Auvergne, Aubi&#232;re 63170, France. rbonnet@chu-clermontferrand.fr.
authors.forename: Richard
authors.initials: R
authors.lastname: Bonnet
authors.affiliation: Microbes, Inflammation, Intestin et Susceptibilit&#233; de l'H&#244;te (M2iSH), Clermont Universit&#233;, Universit&#233; d'Auvergne; INSERM U1071; INRA USC2018, Clermont-Ferrand 63000, France. guillaume.dalmasso@udamail.fr.|Laboratoire de Bact&#233;riologie, Centre Hospitalier Universitaire, Clermont-Ferrand 63000, France. guillaume.dalmasso@udamail.fr.|Institut Universitaire de Technologie, Universit&#233; d'Auvergne, Aubi&#232;re 63170, France. guillaume.dalmasso@udamail.fr.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Dalmasso
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism*; D001427:Bacterial Toxins / Q000378:metabolism*; D002471:Cell Transformation, Neoplastic / Q000378:metabolism / Q000473:pathology; D004249:DNA Damage; D006090:Gram-Negative Bacteria / Q000276:immunology / Q000378:metabolism / Q000472:pathogenicity*; D016905:Gram-Negative Bacterial Infections / Q000276:immunology / Q000378:metabolism / Q000382:microbiology* / Q000473:pathology; D054884:Host-Pathogen Interactions; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D018836:Inflammation Mediators / Q000276:immunology / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D012307:Risk Factors
chemical_list: D001426:Bacterial Proteins; D001427:Bacterial Toxins; D018836:Inflammation Mediators; C067044:cytolethal distending toxin
keywords: CDT toxin; CDT-producing bacteria; DNA damage