title: Genetic association between NFKB1 -94 ins/del ATTG Promoter Polymorphism and cancer risk: a meta-analysis of 42 case-control studies.
abstract: Accumulating evidences have indicated that the functional -94 ins/del ATTG polymorphism in the promoter region of human nuclear factor-kappa B1 (NFKB1) gene may be associated with cancer risk. However, some studies yielded conflicting results. To clarify precise association, we performed a comprehensive meta-analysis of 42 case-control studies involving 43,000 subjects (18,222 cases and 24,778 controls). The overall results suggested that the -94 ins/del ATTG polymorphism had a decreased risk for cancer, reaching significant levels in five genetic models (dominant model: OR = 0.86, 95% CI = 0.79-0.95, P = 0.002; recessive model: OR = 0.84, 95% CI = 0.74-0.94, P = 0.003; homozygous model: OR = 0.77, 95% CI = 0.66-0.90, P = 0.001; heterozygous model: OR = 0.90, 95% CI = 0.83-0.98, P = 0.011; allelic model: OR = 0.89, 95% CI = 0.83-0.96, P = 0.002). Furthermore, the -94 ins/del ATTG polymorphism could confer a decreased or increased risk for cancer development among Asians and Caucasians, respectively. Additionally, the stratification analysis revealed a significant association between the variant and decreased risk of oral, ovarian, and nasopharyngeal cancer in Asians. After we adjusted p values using the Benjamini-Hochberg false discovery rate method to account for multiple comparisons, these associations remained.
authors.affiliation: West China Hospital/West China School of Medicine, Sichuan University, Chengdu, 610041, China.
authors.forename: Duan
authors.initials: D
authors.lastname: Wang
authors.affiliation: West China Hospital/West China School of Medicine, Sichuan University, Chengdu, 610041, China.
authors.forename: Tianhang
authors.initials: T
authors.lastname: Xie
authors.affiliation: Tianjin Hospital, Tianjin, 300211, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Orthopaedics, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, 610041, China.
authors.forename: Haoyang
authors.initials: H
authors.lastname: Wang
authors.affiliation: Center for Joint Surgery, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
authors.forename: Weinan
authors.initials: W
authors.lastname: Zeng
authors.affiliation: School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China.
authors.forename: Shuquan
authors.initials: S
authors.lastname: Rao
authors.affiliation: West China Hospital/West China School of Medicine, Sichuan University, Chengdu, 610041, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Zhou
authors.affiliation: Department of Orthopaedics, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, 610041, China.
authors.forename: Fuxing
authors.initials: F
authors.lastname: Pei
authors.affiliation: Department of Orthopaedics, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, 610041, China.
authors.forename: Zongke
authors.initials: Z
authors.lastname: Zhou
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006720:Homozygote; D006801:Humans; D052002:NF-kappa B p50 Subunit / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D011446:Prospective Studies; D012306:Risk; D044465:White People / Q000235:genetics
chemical_list: D052002:NF-kappa B p50 Subunit; C489548:NFKB1 protein, human