title: Molecular targets of gambogic acid in cancer: recent trends and advancements.
abstract: Natural compounds have been known as biosafety agents for their significant clinical and biological activity against dreadful diseases, including cancer, cardiovascular, and neurodegenerative disorders. Gambogic acid (GA), a naturally occurring xanthone-based moiety, reported from Garcinia hanburyi tree, is known to perform numerous intracellular and extracellular actions, including programmed cell death, autophagy, cell cycle arrest, antiangiogenesis, antimetastatic, and anti-inflammatory activities. In addition, GA-based synergistic approaches have been proven to enhance the healing strength of existing chemotherapeutic agents along with lesser side effects. The present review uncovers the bio-therapeutic potential of gambogic acid along with the possible mechanistic interactions of GA with its recognized cellular targets.
authors.affiliation: Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, Punjab, 160012, India.
authors.forename: Dharambir
authors.initials: D
authors.lastname: Kashyap
authors.affiliation: Department of Biotechnology, Maharishi Markandeshwar University, Mullana-Ambala, Haryana, 133207, India.
authors.forename: Rajkumar
authors.initials: R
authors.lastname: Mondal
authors.affiliation: Department of Biotechnology, Maharishi Markandeshwar University, Mullana-Ambala, Haryana, 133207, India. hardeep.biotech@gmail.com.
authors.forename: Hardeep Singh
authors.initials: HS
authors.lastname: Tuli
authors.affiliation: Department of Biochemistry, Delhi University, South Campus, New Delhi, India.
authors.forename: Gaurav
authors.initials: G
authors.lastname: Kumar
authors.affiliation: Department of Biotechnology, Maharishi Markandeshwar University, Mullana-Ambala, Haryana, 133207, India.
authors.forename: Anil K
authors.initials: AK
authors.lastname: Sharma
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology*; D015398:Signal Transduction / Q000187:drug effects*; D044004:Xanthones / Q000627:therapeutic use*
chemical_list: D044004:Xanthones; C052659:gambogic acid
keywords: Anti-inflammatory; Antiangiogenesis; Antimetastasis; Apoptosis; Autophagy; Gambogic acid; Synergistic effect