title: The role of BRD7 in embryo development and glucose metabolism.
abstract: Bromodomain-containing protein 7 (BRD7) is a member of bromodomain-containing protein family and its function has been implicated in several diseases. We have previously shown that BRD7 plays a role in metabolic processes. However, the effect of BRD7 deficiency in glucose metabolism and its role in in vivo have not been fully revealed. Here, we report the essential role of BRD7 during embryo development. Mice homozygous for BRD7 led to embryonic lethality at mid-gestation. Homozygous BRD7 knockout (KO) mice showed retardation in development, and eventually all BRD7 KO embryos died in utero prior to E16.5. Partial knockdown of Brd7 gene displayed mild changes in glucose metabolism.
authors.affiliation: Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Yoo
authors.initials: Y
authors.lastname: Kim
authors.affiliation: Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Mario
authors.initials: M
authors.lastname: Andrés Salazar Hernández
authors.affiliation: Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Hilde
authors.initials: H
authors.lastname: Herrema
authors.affiliation: Department of Internal Medicine, School of Medicine, Kastamonu, Hacettepe University, Ankara, Turkey.
authors.forename: Tuncay
authors.initials: T
authors.lastname: Delibasi
authors.affiliation: Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Sang Won
authors.initials: SW
authors.lastname: Park
mesh_terms: D000256:Adenoviridae / Q000378:metabolism; D000818:Animals; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics / Q000378:metabolism*; D003433:Crosses, Genetic; D059305:Diet, High-Fat; D020964:Embryo Loss / Q000235:genetics / Q000473:pathology; D047108:Embryonic Development / Q000187:drug effects / Q000235:genetics; D005260:Female; D017353:Gene Deletion; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects; D055785:Gene Knockdown Techniques; D005947:Glucose / Q000378:metabolism*; D006579:Heterozygote; D006706:Homeostasis / Q000187:drug effects / Q000235:genetics; D007328:Insulin / Q000494:pharmacology; D008099:Liver / Q000378:metabolism; D008297:Male; D018345:Mice, Knockout; D011247:Pregnancy; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D034741:RNA, Small Interfering / Q000378:metabolism; D000092468:Bromodomain Containing Proteins
chemical_list: D002868:Chromosomal Proteins, Non-Histone; D005947:Glucose; D007328:Insulin; D012333:RNA, Messenger; D034741:RNA, Small Interfering; C400206:Brd7 protein, mouse; D000092468:Bromodomain Containing Proteins
keywords: bromodomain-containing protein 7; embryogenesis; glucose metabolism