title: Phenotypic Assessment and the Discovery of Topiramate.
abstract: The role of phenotypic assessment in drug discovery is discussed, along with the discovery and development of TOPAMAX (topiramate), a billion-dollar molecule for the treatment of epilepsy and migraine.
authors.affiliation: Baruch S. Blumberg Institute , 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States.
authors.forename: Bruce E
authors.initials: BE
authors.lastname: Maryanoff
keywords: Drug discovery; anticonvulsant; epilepsy; phenotype; topiramate