title: Mycobacteria and Autophagy: Many Questions and Few Answers.
abstract: Tuberculosis (TB) is an ancient disease caused byMycobacterium tuberculosis(Mtb). TB is one of the world's deadliest diseases, with one-third of infected individuals falling ill each year especially in many developing countries. Upon invading host cells, such as macrophages,Mtbcan replicate in infected cells by arresting phagosome maturation and then potentially escaping into the cytosol. Host cells have a mechanism to control intracellularMtbby inducing autophagy, which is an elaborate cellular process to target intracellular pathogens for degradation in infected cells. However, some factors ofMtbare involved in defense against killing by autophagy. Thus, this review highlights the recent advances in the interactions between autophagy andMtb.
authors.affiliation: State-key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070 China.
authors.forename: Min
authors.initials: M
authors.lastname: Liang
authors.affiliation: State-key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070 China.
authors.forename: Zeshan
authors.initials: Z
authors.lastname: Habib
authors.affiliation: Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA, 30602 USA.
authors.forename: Kaori
authors.initials: K
authors.lastname: Sakamoto
authors.affiliation: College of Informatics, Huazhong Agricultural University, Wuhan, 430070 China.
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.affiliation: State-key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070 China.
authors.forename: Gang
authors.initials: G
authors.lastname: Cao
mesh_terms: D000071182:Autophagosomes / Q000502:physiology; D001343:Autophagy; D054884:Host-Pathogen Interactions / Q000502:physiology*; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000472:pathogenicity*