title: The amino-terminal segment in the β-domain of δ-cadinene synthase is essential for catalysis.
abstract: Despite its distance from the active site the flexible amino-terminal segment (NTS) in the β-domain of the plant sesquiterpene cyclase δ-cadinene synthase (DCS) is essential for active site closure and desolvation events during catalysis.
authors.affiliation: School of Chemistry, Cardiff University, Main Building Park Place, Cardiff CF10 3AT, UK. allemannrk@cardiff.ac.uk.
authors.forename: Verónica
authors.initials: V
authors.lastname: González
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Grundy
authors.forename: Juan A
authors.initials: JA
authors.lastname: Faraldos
authors.forename: Rudolf K
authors.initials: RK
authors.lastname: Allemann
mesh_terms: D055162:Biocatalysis; D020134:Catalytic Domain; D003368:Gossypium / Q000201:enzymology; D007535:Isomerases / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D015394:Molecular Structure
chemical_list: D007535:Isomerases; C097608:delta-cadinene synthase