title: Right-handed and left-handed G-quadruplexes have the same DNA sequence: distinct conformations induced by an organic small molecule and potassium.
abstract: Herein, we report two distinct G-quadruplex conformations of the same G-rich oligonucleotide, regulated by a small molecule. This is the first report in which both right- and left-handed G-quadruplex conformations have been obtained from the same sequence. We discriminated these two distinct conformations and investigated their kinetics and thermodynamics.
authors.affiliation: College of Chemistry and Molecular Sciences, Institute of Advanced Studies, Key Laboratory of Biomedical Polymers of Ministry of Education, Wuhan University, Wuhan, Hubei 430072, P. R. China. xzhou@whu.edu.cn srwang@whu.edu.cn.
authors.forename: Boshi
authors.initials: B
authors.lastname: Fu
authors.forename: Jinguo
authors.initials: J
authors.lastname: Huang
authors.forename: Yuqi
authors.initials: Y
authors.lastname: Chen
authors.forename: Yafen
authors.initials: Y
authors.lastname: Wang
authors.forename: Tianrui
authors.initials: T
authors.lastname: Xue
authors.forename: GuoHua
authors.initials: G
authors.lastname: Xu
authors.forename: Shaoru
authors.initials: S
authors.lastname: Wang
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhou
mesh_terms: D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry*; D054856:G-Quadruplexes; D007700:Kinetics; D011188:Potassium / Q000737:chemistry*; D054852:Small Molecule Libraries / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D054852:Small Molecule Libraries; D004247:DNA; D011188:Potassium