title: Cloud-Based NoSQL Open Database of Pulmonary Nodules for Computer-Aided Lung Cancer Diagnosis and Reproducible Research.
abstract: Lung cancer is the leading cause of cancer-related deaths in the world, and its main manifestation is pulmonary nodules. Detection and classification of pulmonary nodules are challenging tasks that must be done by qualified specialists, but image interpretation errors make those tasks difficult. In order to aid radiologists on those hard tasks, it is important to integrate the computer-based tools with the lesion detection, pathology diagnosis, and image interpretation processes. However, computer-aided diagnosis research faces the problem of not having enough shared medical reference data for the development, testing, and evaluation of computational methods for diagnosis. In order to minimize this problem, this paper presents a public nonrelational document-oriented cloud-based database of pulmonary nodules characterized by 3D texture attributes, identified by experienced radiologists and classified in nine different subjective characteristics by the same specialists. Our goal with the development of this database is to improve computer-aided lung cancer diagnosis and pulmonary nodule detection and classification research through the deployment of this database in a cloud Database as a Service framework. Pulmonary nodule data was provided by the Lung Image Database Consortium and Image Database Resource Initiative (LIDC-IDRI), image descriptors were acquired by a volumetric texture analysis, and database schema was developed using a document-oriented Not only Structured Query Language (NoSQL) approach. The proposed database is now with 379 exams, 838 nodules, and 8237 images, 4029 of them are CT scans and 4208 manually segmented nodules, and it is allocated in a MongoDB instance on a cloud infrastructure.
authors.affiliation: Lab of Telemedicine and Medical Informatics, University Hospital Prof. Alberto Antunes, Institute of Computing, Federal University of Alagoas, Av. Lourival Melo Mota, Cidade Universitária, 57072-900, Maceió, Alagoas, Brazil. jrfj@ic.ufal.br.
authors.forename: José Raniery
authors.initials: JR
authors.lastname: Ferreira Junior
authors.affiliation: Lab of Telemedicine and Medical Informatics, University Hospital Prof. Alberto Antunes, Institute of Computing, Federal University of Alagoas, Av. Lourival Melo Mota, Cidade Universitária, 57072-900, Maceió, Alagoas, Brazil.
authors.forename: Marcelo Costa
authors.initials: MC
authors.lastname: Oliveira
authors.affiliation: Center of Imaging Sciences and Medical Physics, Internal Medicine Department, Ribeirão Preto Medical School, University of São Paulo, Av. dos Bandeirantes, Monte Alegre, Ribeirão Preto, São Paulo, Brazil.
authors.forename: Paulo Mazzoncini
authors.initials: PM
authors.lastname: de Azevedo-Marques
mesh_terms: D000067917:Cloud Computing; D016208:Databases, Factual; D003936:Diagnosis, Computer-Assisted; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D011857:Radiographic Image Interpretation, Computer-Assisted; D015203:Reproducibility of Results; D003074:Solitary Pulmonary Nodule / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed
keywords: 3D texture analysis; Cloud computing; Computer-aided detection; Computer-aided diagnosis; Database as a Service; Document-oriented nonrelational database; Image Database Resource Initiative; Lung Image Database Consortium; Lung cancer; MongoDB; NoSQL; Pulmonary nodule; Reproducible research