title: Chronic lymphocytic lymphoma and concomitant renal cell carcinoma (Clear Cell Type): Review of the literature.
abstract: In the present report, a 73 years-old male patient who developed clear cell type renal cell carcinoma (RCC) 5 years after the diagnosis of chronic lymphocytic lymphoma (CLL) and plausible explanations for this association were discussed by the authors. The incidence of CLL and RCC occurring in the same patient is higher than that expected in the general population. Various explicative hypotheses of this concurrence include treatment-related development of a second malignancy, immunomodulatory mechanisms, viral aetiology, cytokine (interleukin 6) release from a tumor, and common genetic mutations. Further investigations are warranted.
authors.affiliation: Fırat University Faculty of Medicine, Department of Internal Medicine, Division of Adult Hematology, Elazığ, Turkey.
authors.forename: Burak
authors.initials: B
authors.lastname: Uz
authors.affiliation: Fırat University Faculty of Medicine, Department of Internal Medicine, Division of Adult Hematology, Elazığ, Turkey.
authors.forename: Ilhan
authors.initials: I
authors.lastname: Dolasik
authors.affiliation: Fırat University Faculty of Medicine, Department of Pathology, Elazığ, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Ucer
authors.affiliation: Fırat University Faculty of Medicine, Department of Pathology, Elazığ, Turkey.
authors.forename: Adile Ferda
authors.initials: AF
authors.lastname: Dagli
authors.affiliation: Fırat University Faculty of Medicine, Department of Pathology, Elazığ, Turkey.
authors.forename: Sercan
authors.initials: S
authors.lastname: Simsek
keywords: Chronic lymphocytic lymphoma; Renal cell carcinoma