title: CD30+ lymphoproliferative disorder with spindle-cell morphology.
abstract: Lymphomatoid papulosis (LyP) is classified as a CD30+ primary cutaneous lymphoproliferative disease. The phenotypic variability along the spectrum of CD30+ lymphoproliferative diseases is highlighted by the distinct histologic subtypes of LyP types A, B, C, and the more recently described types D, E, and F. We report the case of an elderly woman with a clinical presentation and histopathologic findings consistent with LyP, whose atypical CD30+ infiltrate uniquely demonstrated a spindle-cell morphology. To our knowledge, this is the first reported case of LyP characterized by CD30+ spindle-shaped cells, and may represent a new and distinct histologic variant of LyP.
authors.affiliation: The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY, USA.
authors.forename: Kathryn J
authors.initials: KJ
authors.lastname: Martires
authors.affiliation: Department of Dermatology, New York University, School of Medicine, New York, NY, USA.
authors.forename: Brandon E
authors.initials: BE
authors.lastname: Cohen
authors.affiliation: Department of Pathology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA, USA. David.S.Cassarino@kp.org.
authors.forename: David S
authors.initials: DS
authors.lastname: Cassarino
mesh_terms: D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D017730:Ki-1 Antigen / Q000378:metabolism*; D017731:Lymphomatoid Papulosis / Q000175:diagnosis* / Q000276:immunology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000276:immunology
chemical_list: D017730:Ki-1 Antigen
keywords: CD30 positive lymphoproliferative disorder; lymphomatoid papulosis; primary cutaneous anaplastic large cell lymphoma; primary cutaneous lymphoproliferative disease; spindle cells