title: Incidence of Symptomatic Congenital Toxoplasmosis During Ten Years in a Brazilian Hospital.
abstract: Population seroprevalence and rates of mother-to-child transmission are important in determining the incidence of congenital toxoplasmosis. (CT) Mother-to-child transmission depends on the timing of acute maternal infection and treatment during pregnancy. The incidence of CT varies widely across geographic regions, ranging from 1 to 10 cases per 10,000 live births. The incidence of symptomatic disease varies from 0.15 to 0.34 cases per 10,000.
  
  
  
  This is a review of patients treated at a pediatric CT clinic at a university hospital in the south of Brazil, from 2004 to 2014.
  
  
  
  The annual incidence of CT varied from 0 to 14 cases per 10,000 live births, with a mean incidence of 6 cases per 10,000 during the 10 years studied (CI 95%: 3.02-8.91). The incidence of symptomatic CT varied from 0 to 9 cases per 10,000 live births, with a mean incidence of 5 per 10,000 (CI 95%: 2.44-6.94). There were 5 (14.3%) asymptomatic cases. The main findings were retinochoroiditis (54%), intracranial calcifications (37.5%) and altered cerebrospinal fluid (37.5%).
  
  
  
  The incidence of CT and the rate of symptomatic cases were in accordance with the previous data from other studies in Brazil, being significantly higher than in previous North American and European studies.
authors.affiliation: From the *Pediatrics Resident, Pediatrics Department, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; †Pediatrics Department, and ‡Ophthalmology Department, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Adrianne Rahde
authors.initials: AR
authors.lastname: Bischoff
authors.forename: Luciana
authors.initials: L
authors.lastname: Friedrich
authors.forename: Jacobo Melamed
authors.initials: JM
authors.lastname: Cattan
authors.forename: Flávio Antonio de Freitas
authors.initials: FA
authors.lastname: Uberti
mesh_terms: D000293:Adolescent; D000328:Adult; D001938:Brazil / Q000453:epidemiology; D002825:Chorioretinitis; D005260:Female; D006761:Hospitals; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D012189:Retrospective Studies; D014125:Toxoplasmosis, Congenital / Q000453:epidemiology*; D055815:Young Adult