title: Resistance (R) Genes: Applications and Prospects for Plant Biotechnology and Breeding.
abstract: The discovery of novel plant resistance (R) genes (including their homologs and analogs) opened interesting possibilities for controlling plant diseases caused by several pathogens. However, due to environmental pressure and high selection operated by pathogens, several crop plants have lost specificity, broad-spectrum or durability of resistance. On the other hand, the advances in plant genome sequencing and biotechnological approaches, combined with the increasing knowledge on Rgenes have provided new insights on their applications for plant genetic breeding, allowing the identification and implementation of novel and efficient strategies that enhance or optimize their use for efficiently controlling plant diseases. The present review focuses on main perspectives of application of R-genes and its co-players for the acquisition of resistance to pathogens in cultivated plants, with emphasis on biotechnological inferences, including transgenesis, cisgenesis, directed mutagenesis and gene editing, with examples of success and challenges to be faced.
authors.affiliation: Federal University of Pernambuco, Center of Biological Sciences, Department of Genetics, Av. Prof. Moraes Rego, 1235, CEP 50670-420, Recife, PE, Brazil.
authors.forename: Valesca
authors.initials: V
authors.lastname: Pandolfi
authors.forename: Jose Ribamar Costa Ferreira
authors.initials: JRCF
authors.lastname: Neto
authors.forename: Manasses Daniel
authors.initials: MD
authors.lastname: da Silva
authors.forename: Lidiane Lindinalva Barbosa
authors.initials: LLB
authors.lastname: Amorim
authors.forename: Ana Carolina
authors.initials: AC
authors.lastname: Wanderley-Nogueira
authors.forename: Roberta Lane
authors.initials: RL
authors.lastname: de Oliveira Silva
authors.forename: Ederson Akio
authors.initials: EA
authors.lastname: Kido
authors.forename: Sergio
authors.initials: S
authors.lastname: Crovella
authors.forename: Ana Maria Benko
authors.initials: AMB
authors.lastname: Iseppon
mesh_terms: D029681:Arabidopsis Proteins / Q000235:genetics / Q000276:immunology*; D001709:Biotechnology / Q000379:methods; D064113:CRISPR-Cas Systems; D060467:Disease Resistance / Q000235:genetics*; D000072669:Gene Editing / Q000379:methods; D018506:Gene Expression Regulation, Plant / Q000276:immunology*; D054884:Host-Pathogen Interactions / Q000235:genetics / Q000276:immunology; D016297:Mutagenesis, Site-Directed; D000069600:Plant Breeding / Q000379:methods; D010935:Plant Diseases / Q000235:genetics / Q000276:immunology*; D057865:Plant Immunity / Q000235:genetics; D010940:Plant Proteins / Q000235:genetics / Q000276:immunology*; D010944:Plants / Q000235:genetics* / Q000276:immunology / Q000382:microbiology / Q000821:virology; D030821:Plants, Genetically Modified; D020033:Protein Isoforms / Q000235:genetics / Q000276:immunology; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000276:immunology*; D015398:Signal Transduction
chemical_list: D029681:Arabidopsis Proteins; D010940:Plant Proteins; D020033:Protein Isoforms; C418462:RPW8.1 protein, Arabidopsis; C084354:Pto protein, Lycopersicon; D017346:Protein Serine-Threonine Kinases
keywords: Disease resistance; directed mutagenesis; genetic modification; plant pathogen