title: PICSAR: Long Noncoding RNA in Cutaneous Squamous Cell Carcinoma.
abstract: It is increasingly evident that long noncoding RNAs may play the roles of both oncogenes and tumor suppressors during cancer development. A new study from Piipponen et al. provides evidence that a long noncoding RNA, PICSAR, promotes cutaneous squamous cell carcinoma development through activation of extracellular signal-regulated kinase signaling. Because specific inhibition of PICSAR suppresses tumor growth, this long noncoding RNA may serve as a useful diagnostic marker and therapeutic target for cutaneous squamous cell carcinoma.
authors.affiliation: Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California 94305, USA.
authors.forename: Yunhai
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California 94305, USA.
authors.forename: Stefanie L
authors.initials: SL
authors.lastname: Morgan
authors.affiliation: Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California 94305, USA; Veterans Affairs Palo Alto Healthcare System, Palo Alto, California 94304, USA. Electronic address: kevwang@stanford.edu.
authors.forename: Kevin C
authors.initials: KC
authors.lastname: Wang
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D048049:Extracellular Signal-Regulated MAP Kinases; D006801:Humans; D062085:RNA, Long Noncoding / Q000235:genetics*; D015398:Signal Transduction; D012878:Skin Neoplasms
chemical_list: D062085:RNA, Long Noncoding; D048049:Extracellular Signal-Regulated MAP Kinases