title: Long-term treatment with the oncolytic ECHO-7 virus Rigvir of a melanoma stage IV M1c patient, a small cell lung cancer stage IIIA patient, and a histiocytic sarcoma stage IV patient-three case reports.
abstract: Oncolytic virotherapy is a recent addition to cancer treatment. Here, we describe positive treatment outcomes in three patients using Rigvir virotherapy. One of the patients is diagnosed with melanoma stage IV M1c, one with small cell lung cancer stage IIIA, and one with histiocytic sarcoma stage IV. The diagnoses of all patients are verified by histology or cytology. All patients started Rigvir treatment within a few months after being diagnosed and are currently continuing Rigvir treatment. The degree of regression of the disease has been determined by computed tomography. Safety assessment of adverse events graded according to NCI CTCAE did not show any value above grade 1 during Rigvir(®) treatment. Using current standard treatments, the survival of patients with the present diagnoses is low. In contrast, the patients described here were diagnosed 3.5, 7.0, and 6.6 years ago, and their condition has improved and been stabile for over 1.5, 6.5, and 4 years, respectively. These observations suggest that virotherapy using Rigvir can successfully be used in long-term treatment of patients with melanoma stage IV M1c, small cell lung cancer stage IIIA, and histiocytic sarcoma stage IV and therefore could be included in prospective clinical studies.
authors.affiliation: International Virotherapy Center, Riga, Latvia. peteris@virotherapy.eu.
authors.forename: Pēteris
authors.initials: P
authors.lastname: Alberts
authors.affiliation: Department of Radiology, Pauls Stradiņš Clinical University Hospital, Riga, Latvia.
authors.forename: Evija
authors.initials: E
authors.lastname: Olmane
authors.affiliation: International Virotherapy Center, Riga, Latvia.
authors.forename: Linda
authors.initials: L
authors.lastname: Brokāne
authors.affiliation: Department of Radiology, Pauls Stradiņš Clinical University Hospital, Riga, Latvia.
authors.forename: Zanda
authors.initials: Z
authors.lastname: Krastiņa
authors.affiliation: Department of Cytology, Pauls Stradiņš Clinical University Hospital, Riga, Latvia.
authors.forename: Māra
authors.initials: M
authors.lastname: Romanovska
authors.affiliation: Department of Radiology, Pauls Stradiņš Clinical University Hospital, Riga, Latvia.|Department of Radiology, Riga Stradiņš University, Riga, Latvia.
authors.forename: Kārlis
authors.initials: K
authors.lastname: Kupčs
authors.affiliation: Department of Pathology, Riga Eastern Clinical University Hospital, Riga, Latvia.|Department of Pathology, Faculty of Medicine, University of Latvia, Riga, Latvia.
authors.forename: Sergejs
authors.initials: S
authors.lastname: Isajevs
authors.affiliation: Outpatient Department, Riga Eastern Clinical University Hospital, Riga, Latvia.
authors.forename: Guna
authors.initials: G
authors.lastname: Proboka
authors.affiliation: ER Clinic, Riga, Latvia.
authors.forename: Romualds
authors.initials: R
authors.lastname: Erdmanis
authors.affiliation: Institute of Pathology, Pauls Stradiņš Clinical University Hospital, Riga, Latvia.
authors.forename: Jurijs
authors.initials: J
authors.lastname: Nazarovs
authors.affiliation: International Virotherapy Center, Riga, Latvia.
authors.forename: Dite
authors.initials: D
authors.lastname: Venskus
mesh_terms: D000369:Aged, 80 and over; D003584:Cytological Techniques; D064420:Drug-Related Side Effects and Adverse Reactions; D029822:Enterovirus B, Human; D005260:Female; D005500:Follow-Up Studies; D054747:Histiocytic Sarcoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D006651:Histocytochemistry; D006801:Humans; D008297:Male; D008545:Melanoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D008875:Middle Aged; D009367:Neoplasm Staging; D050130:Oncolytic Virotherapy / Q000379:methods*; D011446:Prospective Studies; D055752:Small Cell Lung Carcinoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
keywords: Histiocytic sarcoma; Rigvir; immunotherapy; melanoma; oncolytic virotherapy; small cell lung cancer; virotherapy