title: Dynamic Patterns of Brain Structure-Behavior Correlation Across the Lifespan.
abstract: Although the brain/behavior correlation is one of the premises of cognitive neuroscience, there is still no consensus about the relationship between brain measures and cognitive function, and only little is known about the effect of age on this relationship. We investigated the age-associated variations on the spatial patterns of cortical thickness correlates of four cognitive domains. We showed that the spatial distribution of the cortical thickness correlates of each cognitive domain is distinctive and depicts varying age-association differences across the adult lifespan. Specifically, the present study provides evidence that distinct cognitive domains are associated with unique structural patterns in three adulthood periods: Early, middle, and late adulthood. These findings suggest a dynamic interaction between multiple neural substrates supporting each cognitive domain across the adult lifespan.
authors.affiliation: Department of Neurology.|Biomedical Engineering Department.
authors.forename: Qolamreza R
authors.initials: QR
authors.lastname: Razlighi
authors.affiliation: Department of Neurology.
authors.forename: Hwamee
authors.initials: H
authors.lastname: Oh
authors.affiliation: Department of Neurology.
authors.forename: Christian
authors.initials: C
authors.lastname: Habeck
authors.affiliation: Department of Neurology.
authors.forename: Deirdre
authors.initials: D
authors.lastname: O'Shea
authors.affiliation: Department of Neurology.
authors.forename: Elaine
authors.initials: E
authors.lastname: Gazes
authors.affiliation: Department of Neurology.
authors.forename: Teal
authors.initials: T
authors.lastname: Eich
authors.affiliation: Biomedical Engineering Department.
authors.forename: David B
authors.initials: DB
authors.lastname: Parker
authors.affiliation: Department of Psychiatry and Biostatistics, Columbia University, New York, NY 10032, USA.
authors.forename: Seonjoo
authors.initials: S
authors.lastname: Lee
authors.affiliation: Department of Neurology.
authors.forename: Yaakov
authors.initials: Y
authors.lastname: Stern
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D001921:Brain / Q000000981:diagnostic imaging* / Q000502:physiology*; D001931:Brain Mapping; D003071:Cognition / Q000502:physiology*; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D007091:Image Processing, Computer-Assisted; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D061212:Memory, Episodic; D008875:Middle Aged; D009483:Neuropsychological Tests; D011932:Reading; D014705:Verbal Behavior; D055815:Young Adult
keywords: adult lifespan; aging; brain behavior correlation; cognitive domain; cortical thickness