title: Characterization of oscillatory changes in hippocampus and amygdala after deep brain stimulation of the infralimbic prefrontal cortex.
abstract: Deep brain stimulation (DBS) is a new investigational therapy that has generated positive results in refractory depression. Although the neurochemical and behavioral effects of DBS have been examined, less attention has been paid to the influence of DBS on the network dynamics between different brain areas, which could contribute to its therapeutic effects. Herein, we set out to identify the effects of 1 h DBS in the infralimbic cortex (IL) on the oscillatory network dynamics between hippocampus and basolateral amygdala (BLA), two regions implicated in depression and its treatment. Urethane-anesthetized rats with bilaterally implanted electrodes in the IL were exposed to 1 h constant stimulation of 130 Hz of frequency, 60 μA of constant current intensity and biphasic pulse width of 80 μsec. After a period of baseline recording, local field potentials (LFP) were recorded with formvar-insulated stainless steel electrodes. DBS of the IL increased the power of slow wave (SW, <1.5 Hz) and theta (3-12 Hz) frequencies in the hippocampus and BLA Furthermore, IL DBS caused a precise coupling in different frequency bands between both brain structures. The increases in SW band synchronization in hippocampus and BLA after DBS suggest that these changes may be important for the improvement of depressive behavior. In addition, the augmentation in theta synchrony might contribute to improvement in emotional and cognitive processes.
authors.affiliation: Neuronal Circuits Laboratory, Department of Human Anatomy and Embriology, Faculty of Medicine and Odontology University of Valencia, Valencia, 46010, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Cervera-Ferri
authors.affiliation: Neuronal Circuits Laboratory, Department of Human Anatomy and Embriology, Faculty of Medicine and Odontology University of Valencia, Valencia, 46010, Spain.
authors.forename: Vicent
authors.initials: V
authors.lastname: Teruel-Martí
authors.affiliation: Neuronal Circuits Laboratory, Department of Human Anatomy and Embriology, Faculty of Medicine and Odontology University of Valencia, Valencia, 46010, Spain Instituto de Investigación Sanitaria La Fe, Valencia, 46026, Spain.
authors.forename: Moises
authors.initials: M
authors.lastname: Barceló-Molina
authors.affiliation: Neuronal Circuits Laboratory, Department of Human Anatomy and Embriology, Faculty of Medicine and Odontology University of Valencia, Valencia, 46010, Spain.
authors.forename: Joana
authors.initials: J
authors.lastname: Martínez-Ricós
authors.affiliation: Neuronal Circuits Laboratory, Department of Human Anatomy and Embriology, Faculty of Medicine and Odontology University of Valencia, Valencia, 46010, Spain Instituto de Investigación Sanitaria La Fe, Valencia, 46026, Spain.
authors.forename: Aina
authors.initials: A
authors.lastname: Luque-García
authors.affiliation: Neuronal Circuits Laboratory, Department of Human Anatomy and Embriology, Faculty of Medicine and Odontology University of Valencia, Valencia, 46010, Spain Department of Cell Biology and Parasitology, Faculty of Medicine and Odontology University of Valencia, Valencia, 46010, Spain.
authors.forename: Sergio
authors.initials: S
authors.lastname: Martínez-Bellver
authors.affiliation: Institute of Biomedicine and Biotechnology of Cantabria, IBBTEC (CSIC University of Cantabria), Santander, 39011, Spain albert.adell@unican.es.
authors.forename: Albert
authors.initials: A
authors.lastname: Adell
mesh_terms: D000679:Amygdala / Q000502:physiology*; D000818:Animals; D001522:Behavior, Animal; D058256:Brain Waves; D046690:Deep Brain Stimulation; D004569:Electroencephalography; D006624:Hippocampus / Q000502:physiology*; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D017397:Prefrontal Cortex / Q000502:physiology*; D017208:Rats, Wistar; D012815:Signal Processing, Computer-Assisted; D013997:Time Factors
keywords: Antidepressant; brain oscillations; local field potential; modulatory index; mutual information