title: One-pot sequential asymmetric hydrogenation of β-aryl-β-aryloxy acroleins.
abstract: A one-pot sequential asymmetric hydrogenation of β-aryl-β-aryloxy acroleins has been realized for the preparation of chiral 3-aryl-3-aryloxy alcohols with excellent yields and good enantioselectivities. This methodology can be employed in new synthetic routes for the synthesis of fluoxetine, atomoxetine, and related analogues.
authors.affiliation: School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P. R. China.
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Liu
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Chen
authors.forename: Zhenfeng
authors.initials: Z
authors.lastname: Zhang
authors.forename: Jian
authors.initials: J
authors.lastname: Qin
authors.forename: Min
authors.initials: M
authors.lastname: Zhao
authors.forename: Wanbin
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000171:Acrolein / Q000737:chemistry*; D000438:Alcohols / Q000138:chemical synthesis* / Q000737:chemistry; D006865:Hydrogenation; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D000171:Acrolein