title: [Cervical cancer screening with primary HPV-DNA test in the Local Health Authority 2 of Savona (Liguria Region, Northern Italy): a population-based study].
abstract: OBJECTIVE
  to describe the performance and the impact on the population coverage of a population-based organised screening programme with primary HPV-DNA test.
  
  
  METHODS
  population-based cohort study.
  
  
  METHODS
  organised screening programme for women aged 30-64 years.
  
  
  METHODS
  coverage of the target population with Pap test and HPV-DNA test, compliance to invitation, positivity at HPV-DNA testing, proportion of positive Pap test (squamous cells of undetermined significance or more severe, ASC-US+), referral for colposcopy, positive predictive value (PPV) of the cytology triage for grade-2 or more severe intraepithelial neoplasia (CIN2+), detection rate of CIN2+. Regarding coverage, seasonally adjusted trends of the PASSI surveillance from 2008 to 2014 were analysed. To evaluate performance, data of the information screening system were used.
  
  
  RESULTS
  from December 2011 to December 2014, 48,852 women were invited for screening and 22,991 participated (48.4%); in addition, 968 women spontaneously participated in the programme, achieving a total of 23,959 screened women. The HPV test resulted positive for 2,000 women (8.4%). After triage 1,049 women were referred for colposcopy because of ASC-US+ (No. 968) or inadequate result (No. 81). The compliance at 12 months retesting among women with positive HPV test and negative triage was 79.3%, and the HPV positive rate was 60.4%. In the whole, 1,322 women were referred for colposcopy (5.5%) and 1,221 were actually tested. The overall detection rate for CIN2+ was 6.2/1,000. From 2011 to 2014, spontaneous Pap tests passed from 7,461/year to 2,491/year; the test coverage achieved a positive trend and it settles in recent years to 83%, including 43% of HPV-DNA.
  
  
  CONCLUSIONS
  compliance to screening of invited women was satisfactory compared to previous experiences in Liguria Region (Northern Italy). Performance indicators confirm what was observed in other Italian experiences.
authors.affiliation: SC anatomia patologica, ASL 2 savonese, Savona. elisabetta.depetrini84@gmail.com.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Depetrini
authors.affiliation: IRCCS azienda ospedaliera universitaria San Martino - IST, Genova.
authors.forename: Luigina
authors.initials: L
authors.lastname: Bonelli
authors.affiliation: SC anatomia patologica, ASL 2 savonese, Savona.
authors.forename: Silvia
authors.initials: S
authors.lastname: Ardoino
authors.affiliation: SC anatomia patologica, ASL 2 savonese, Savona.
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Cirucca
authors.affiliation: Dipartimento cure primarie e attività distrettuali, ASL 2 savonese, Savona.
authors.forename: Renzo
authors.initials: R
authors.lastname: Contin
authors.affiliation: SC anatomia patologica, ASL 2 savonese, Savona.
authors.forename: Damiana
authors.initials: D
authors.lastname: De Leonardis
authors.affiliation: SC anatomia patologica, ASL 2 savonese, Savona.
authors.forename: Veronica
authors.initials: V
authors.lastname: Errigo
authors.affiliation: Dipartimento cure primarie e attività distrettuali, ASL 2 savonese, Savona.
authors.forename: Andrea
authors.initials: A
authors.lastname: Lugani
authors.affiliation: Segreteria organizzativa screening oncologici, ASL 2 savonese, Savona.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Franco
authors.affiliation: SC anatomia patologica, ASL 2 savonese, Savona.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Pastorino
authors.affiliation: Dipartimento di sanità pubblica, AUSL Modena.
authors.forename: Giuliano
authors.initials: G
authors.lastname: Carrozzi
authors.affiliation: SC anatomia patologica, ASL 2 savonese, Savona.
authors.forename: Ezio
authors.initials: E
authors.lastname: Venturino
mesh_terms: D000328:Adult; D015331:Cohort Studies; D003127:Colposcopy / Q000379:methods; D055088:Early Detection of Cancer; D005260:Female; D061809:Human Papillomavirus DNA Tests / Q000379:methods* / Q000706:statistics & numerical data; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008875:Middle Aged; D065006:Papanicolaou Test / Q000379:methods; D030361:Papillomavirus Infections / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D010349:Patient Compliance / Q000706:statistics & numerical data; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000821:virology