title: Head and Neck Cutaneous Squamous Cell Carcinoma Clinicopathological Risk Factors according to Age and Gender: A Population-based Study.
abstract: BACKGROUND
  Clinicopathological risk factors for cutaneous squamous cell carcinoma of the head and neck (CSCCHN) are associated with local recurrence and metastasis.
  
  
  OBJECTIVE
  To compare the incidence and risk factors of CSCCHN by age and gender in order to help refine the clinical evaluation and treatment process.
  
  
  METHODS
  Clinical and pathological data of all patients diagnosed with CSCCHN during 2009-2011 were obtained from a central pathology laboratory in Israel. Estimated incidence rate calculation was standardized to the 2010 Israeli population. Independent risk factors for poorly differentiated CSCCHN were analyzed using logistic regression.
  
  
  RESULTS
  CSCCHN was diagnosed in 621 patients. Mean age was 75.2 years; mean tumor horizontal diameter was 11.1 ± 6.8 mm. The overall estimated incidence rate in males was higher than in females (106.2 vs. 54.3 per 1,000,000, P 0.001). Twenty cases (3.2%) had poorly differentiated CSCCHN. Scalp and ear anatomic locations were observed more often in males than in females (22.1% vs. 6.1% and 20.3% vs. 3.3%, respectively, P < 0.001). Per 1 mm increment, tumor horizontal diameter increased the risk for poorly differentiated CSCCHN by 6.7% (95% CI 1.3-12.4%, P = 0.014).
  
  
  CONCLUSIONS
  CSCCHN clinicopathological risk factors are not distributed evenly among different age and gender groups.
authors.forename: Itay
authors.initials: I
authors.lastname: Wiser
authors.forename: Alon
authors.initials: A
authors.lastname: Scope
authors.forename: David
authors.initials: D
authors.lastname: Azriel
authors.forename: Elhanan
authors.initials: E
authors.lastname: Zloczower
authors.forename: Narin N
authors.initials: NN
authors.lastname: Carmel
authors.forename: Avshalom
authors.initials: A
authors.lastname: Shalom
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000473:pathology; D015331:Cohort Studies; D005260:Female; D006258:Head and Neck Neoplasms / Q000453:epidemiology / Q000473:pathology; D006801:Humans; D015994:Incidence; D007557:Israel / Q000453:epidemiology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D012878:Skin Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology; D000077195:Squamous Cell Carcinoma of Head and Neck; D047368:Tumor Burden