title: Regional Coherence Alterations Revealed by Resting-State fMRI in Post-Stroke Patients with Cognitive Dysfunction.
abstract: OBJECTIVE
  Post-stroke cognitive dysfunction greatly influences patients' quality of life after stroke. However, its neurophysiological basis remains unknown. This study utilized resting-state functional magnetic resonance imaging (fMRI) to investigate the alterations in regional coherence in patients after subcortical stroke.
  
  
  METHODS
  Resting-state fMRI measurements were acquired from 16 post-stroke patients with poor cognitive function (PSPC), 16 post-stroke patients with good cognitive function (PSGC) and 30 well-matched healthy controls (HC). Regional homogeneity (ReHo) was used to detect alterations in regional coherence. Abnormalities in regional coherence correlated with scores on neuropsychological scales.
  
  
  RESULTS
  Compared to the HC and the PSGC, the PSPC showed remarkably decreased ReHo in the bilateral anterior cingulate cortex and the left posterior cingulate cortex/precuneus. ReHo in the bilateral anterior cingulate cortex positively correlated with the scores on the Symbol Digit Modalities Test (r = 0.399, P = 0.036) and the Complex Figure Test-delayed recall subtest (r = 0.397, P = 0.036) in all post-stroke patients. Moreover, ReHo in the left posterior cingulate cortex/precuneus positively correlated with the scores on the Forward Digit Span Test (r = 0.485, P = 0.009) in all post-stroke patients.
  
  
  CONCLUSIONS
  Aberrant regional coherence was observed in the anterior and posterior cingulate cortices in post-stroke patients with cognitive dysfunction. ReHo could represent a promising indicator of neurobiological deficiencies in post-stroke patients.
authors.affiliation: Jiangsu Key Laboratory of Molecular and Functional Imaging, Medical School of Southeast University, Nanjing, Jiangsu, China.|Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, Jiangsu, China.
authors.forename: Cheng-Yu
authors.initials: CY
authors.lastname: Peng
authors.affiliation: Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Yu-Chen
authors.initials: YC
authors.lastname: Chen
authors.affiliation: Jiangsu Key Laboratory of Molecular and Functional Imaging, Medical School of Southeast University, Nanjing, Jiangsu, China.|Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, Jiangsu, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Cui
authors.affiliation: Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, Jiangsu, China.
authors.forename: Deng-Ling
authors.initials: DL
authors.lastname: Zhao
authors.affiliation: Jiangsu Key Laboratory of Molecular and Functional Imaging, Medical School of Southeast University, Nanjing, Jiangsu, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Jiao
authors.affiliation: Jiangsu Key Laboratory of Molecular and Functional Imaging, Medical School of Southeast University, Nanjing, Jiangsu, China.
authors.forename: Tian-Yu
authors.initials: TY
authors.lastname: Tang
authors.affiliation: Jiangsu Key Laboratory of Molecular and Functional Imaging, Medical School of Southeast University, Nanjing, Jiangsu, China.|Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, Jiangsu, China.
authors.forename: Shenghong
authors.initials: S
authors.lastname: Ju
authors.affiliation: Jiangsu Key Laboratory of Molecular and Functional Imaging, Medical School of Southeast University, Nanjing, Jiangsu, China.|Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, Jiangsu, China.
authors.forename: Gao-Jun
authors.initials: GJ
authors.lastname: Teng
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D001931:Brain Mapping; D016022:Case-Control Studies; D003071:Cognition; D060825:Cognitive Dysfunction / Q000175:diagnosis* / Q000209:etiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012146:Rest; D012307:Risk Factors; D020521:Stroke / Q000150:complications* / Q000523:psychology*