title: Salvage surgery after head and neck squamous cell carcinoma treated with bioradiotherapy.
abstract: The purpose of this study was to describe the results and complications of primary site salvage surgery after head and neck squamous cell carcinoma (HNSCC) treated with bioradiotherapy.
  
  
  
  We conducted a retrospective chart review of 268 patients treated with bioradiotherapy between March 2006 and December 2013 at the Hospital Universitari de Bellvitge-ICO.
  
  
  
  Fifty-nine patients developed local recurrence or had residual disease with a 1-year and 3-year overall survival of 47% and 15.4%, respectively. Salvage surgery was feasible in 22 patients (37.3%). There were 16 complications in these 22 patients (72.7%), 11 (50%) of which were major. Bilateral neck dissection was identified as a risk factor for complications.
  
  
  
  Salvage surgery after bioradiotherapy is associated with a high rate of complications. Neck dissection seems to be related to an increased rate of complications with no survival improvement. © 2016 Wiley Periodicals, Inc. Head Neck 39: 116-121, 2017.
authors.affiliation: Department of Otorhinolaryngology, Bellvitge University Hospital, Universitat de Barcelona, Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: Aleix
authors.initials: A
authors.lastname: Rovira
authors.affiliation: Department of Otorhinolaryngology, Bellvitge University Hospital, Universitat de Barcelona, Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: Jordi
authors.initials: J
authors.lastname: Tornero
authors.affiliation: Department of Medical Oncology, Catalan Institute of Oncology, Universitat de Barcelona, Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: Marc
authors.initials: M
authors.lastname: Oliva
authors.affiliation: Department of Medical Oncology, Catalan Institute of Oncology, Universitat de Barcelona, Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: Miren
authors.initials: M
authors.lastname: Taberna
authors.affiliation: Department of Medical Oncology, Catalan Institute of Oncology, Universitat de Barcelona, Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: Robert
authors.initials: R
authors.lastname: Montal
authors.affiliation: Department of Otorhinolaryngology, Bellvitge University Hospital, Universitat de Barcelona, Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: Julio
authors.initials: J
authors.lastname: Nogues
authors.affiliation: Department of Otorhinolaryngology, Bellvitge University Hospital, Universitat de Barcelona, Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: Anna
authors.initials: A
authors.lastname: Farre
authors.affiliation: Department of Otorhinolaryngology, Bellvitge University Hospital, Universitat de Barcelona, Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: Henry
authors.initials: H
authors.lastname: Lares
authors.affiliation: Statistics Unit, Hospital Duran I Reynalds, Catalan Institute of Oncology, Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: Valenti
authors.initials: V
authors.lastname: Navarro
authors.affiliation: Department of Maxillofacial Surgery, Bellvitge University Hospital, Universitat de Barcelona, Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: Antoni
authors.initials: A
authors.lastname: Mari
authors.affiliation: Department of Plastic and Reconstructive Surgery, Bellvitge University Hospital, Universitat de Barcelona, Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: Joan Maria
authors.initials: JM
authors.lastname: Vinals
authors.affiliation: Department of Radiotherapy, Hospital Duran I Reynalds, Catalan Institute of Oncology, Universitat de Barcelona, Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: Alicia
authors.initials: A
authors.lastname: Lozano
authors.affiliation: Department of Medical Oncology, Catalan Institute of Oncology, Universitat de Barcelona, Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: Ricard
authors.initials: R
authors.lastname: Mesia
authors.affiliation: Department of Otorhinolaryngology, Bellvitge University Hospital, Universitat de Barcelona, Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: Manel
authors.initials: M
authors.lastname: Manos
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D003131:Combined Modality Therapy; D000072700:Conservative Treatment; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D012189:Retrospective Studies; D016879:Salvage Therapy; D000077195:Squamous Cell Carcinoma of Head and Neck; D015996:Survival Rate
keywords: bioradiotherapy; cetuximab; head and neck cancer; head and neck squamous cell carcinoma; salvage surgery