title: Hereditary lactate dehydrogenase M-subunit deficiency with late-developing pustular psoriasis-like lesions.
abstract: Hereditary lactate dehydrogenase (LDH) M-subunit deficiency is very rare and we have found reports of close to a dozen cases in the published work, two of which were associated with pustular psoriasis-like lesions. We report a third case of pustular psoriasis-like eruptions associated with LDH M-subunit deficiency, which occurred 24 years after the diagnosis of LDH M-subunit deficiency. These cases indicate that abnormal activity of LDH can induce pustular psoriatic lesions in the long term. Some patients with symptoms of hereditary LDH M-subunit deficiency have antecedent annular scaly plaque lesions, that resemble psoriatic lesions. We discuss a hypothesis to explain this scenario.
authors.affiliation: Department of Dermatology, Faculty of Medicine, Oita University, Yufu, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Takeo
authors.affiliation: Department of Dermatology, Faculty of Medicine, Oita University, Yufu, Japan.
authors.forename: Sakuhei
authors.initials: S
authors.lastname: Fujiwara
authors.affiliation: Department of Dermatology, Faculty of Medicine, Oita University, Yufu, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Sakai
authors.affiliation: Department of Dermatology, Faculty of Medicine, Oita University, Yufu, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Saito-Shono
authors.affiliation: Department of Dermatology, Faculty of Medicine, Oita University, Yufu, Japan.
authors.forename: Kazushi
authors.initials: K
authors.lastname: Ishikawa
authors.affiliation: Department of Dermatology, Faculty of Medicine, Oita University, Yufu, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Hatano
mesh_terms: D000328:Adult; D000595:Amino Acid Sequence / Q000235:genetics; D001706:Biopsy; D005091:Exons / Q000235:genetics; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007150:Immunohistochemistry; D007527:Isoenzymes / Q000172:deficiency / Q000235:genetics; D007770:L-Lactate Dehydrogenase / Q000172:deficiency* / Q000235:genetics*; D000080864:Lactate Dehydrogenase 5; D011239:Prednisolone / Q000627:therapeutic use; D011565:Psoriasis / Q000188:drug therapy / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D035583:Rare Diseases / Q000235:genetics*; D017422:Sequence Analysis, DNA; D017423:Sequence Analysis, RNA; D017384:Sequence Deletion; D012867:Skin / Q000473:pathology; D013997:Time Factors; D014633:Valine / Q000235:genetics
chemical_list: D005938:Glucocorticoids; D007527:Isoenzymes; D012333:RNA, Messenger; D011239:Prednisolone; D007770:L-Lactate Dehydrogenase; D000080864:Lactate Dehydrogenase 5; D014633:Valine
keywords: 
  nicotinamide adenine dinucleotide
  ; lactate dehydrogenase; lactate dehydrogenase-M subunit deficiency; pellagra; pustular psoriasis