title: [Impact of premature rupture of membranes on neonatal complications in preterm infants with gestational age <37 weeks].
abstract: OBJECTIVE
  To investigate the effect of premature rupture of the membrane (PROM) on neonatal complications in premature infants.
  
  
  METHODS
  The registration information of 7684 preterm infants with gestational age <37 weeks were collected from the cooperative units in the task group between January 1, 2014 to December 31, 2014. Specially trained personnel from each cooperative units filled in the unified form in a standardized format to record the gender, gestational age, birth weight, PROM, placental abruption, antenatal corticosteroid, Apgar score, amniotic fluid pollution, and complications of the infants. The data were analyzed comparatively between the cases with PROM and those without (control).
  
  
  RESULTS
  The preterm mortality rate was significantly lower but the incidences of ICH, NEC, ROP and BPD were significantly higher in PROM group than in the control group (P<0.05). The 95% confidence interval of the OR value was <1 for mortality, and was >1 for ICH, NEC, ROP and BPD. After adjustment for gestational age, birth weight, gender, mode of delivery, placental abruption, placenta previa, prenatal hormones, gestational diabetes mellitus (GDM), gestational period hypertension and 5-min Apgar score <7, the incidences of NEC, ROP and BPD were significantly different between the two groups (P<0.05) with 95% confidence interval of OR value >1, but the mortality rate and incidence of ICH were not significantly different between the two groups (P>0.05).
  
  
  CONCLUSIONS
  PROM is a risk factor for NEC, ROP and BPD in preterm infants, and adequate intervention of PROM can reduce the incidences of such complications as NEC, ROP and BPD in the infants.
authors.affiliation: Department of Very Preterm NICU, BaYi Children's Hospital Affiliated to Clinical Medical College in Army General Hospital Of Southern Medical University, Beijing, 100700, China.E-mail: neoduan0919@163.com.
authors.forename: Shun-Yan
authors.initials: SY
authors.lastname: Duan
authors.forename: Xiang-Yong
authors.initials: XY
authors.lastname: Kong
authors.forename: Feng-Dan
authors.initials: FD
authors.lastname: Xu
authors.forename: Hong-Yan
authors.initials: HY
authors.lastname: Lv
authors.forename: Rong
authors.initials: R
authors.lastname: Ju
authors.forename: Zhan-Kui
authors.initials: ZK
authors.lastname: Li
authors.forename: Shu-Juan
authors.initials: SJ
authors.lastname: Zeng
authors.forename: Hui
authors.initials: H
authors.lastname: Wu
authors.forename: Xue-Feng
authors.initials: XF
authors.lastname: Zhang
authors.forename: Wei-Peng
authors.initials: WP
authors.lastname: Liu
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.forename: Hong-Bin
authors.initials: HB
authors.lastname: Cheng
authors.forename: Yan-Jie
authors.initials: YJ
authors.lastname: Ding
authors.forename: Tie-Qiang
authors.initials: TQ
authors.lastname: Chen
authors.forename: Ping
authors.initials: P
authors.lastname: Xu
authors.forename: Li-Hong
authors.initials: LH
authors.lastname: Yang
authors.forename: Su-Jing
authors.initials: SJ
authors.lastname: Wu
authors.forename: Jin
authors.initials: J
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Peng
authors.forename: Xiao-Lin
authors.initials: XL
authors.lastname: Zhao
authors.forename: Hui-Xian
authors.initials: HX
authors.lastname: Qiu
authors.forename: Wei-Xi
authors.initials: WX
authors.lastname: Wen
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.forename: Lan
authors.initials: L
authors.lastname: Li
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wen
authors.forename: Guo
authors.initials: G
authors.lastname: Guo
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.forename: Gai-Mei
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authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Xiao-Ying
authors.initials: XY
authors.lastname: Zhao
authors.forename: Yun-Bo
authors.initials: YB
authors.lastname: Xu
authors.forename: Wen-Chao
authors.initials: WC
authors.lastname: Chen
authors.forename: Huan
authors.initials: H
authors.lastname: Yin
authors.forename: Xiao-Liang
authors.initials: XL
authors.lastname: Wang
authors.forename: Rui-Yan
authors.initials: RY
authors.lastname: Shan
authors.forename: Mei-Ying
authors.initials: MY
authors.lastname: Han
authors.forename: Chun-Yan
authors.initials: CY
authors.lastname: Yang
authors.forename: Zhi-Chun
authors.initials: ZC
authors.lastname: Feng
mesh_terms: D001034:Apgar Score; D001724:Birth Weight; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000473:pathology*; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000209:etiology*; D007234:Infant, Premature; D011247:Pregnancy; D012307:Risk Factors