title: Targeted Molecular Imaging of Cancer Cells Using MS2-Based (129)Xe NMR.
abstract: We have synthesized targeted, selective, and highly sensitive (129)Xe NMR nanoscale biosensors using a spherical MS2 viral capsid, Cryptophane A molecules, and DNA aptamers. The biosensors showed strong binding specificity toward targeted lymphoma cells (Ramos line). Hyperpolarized (129)Xe NMR signal contrast and hyper-CEST (129)Xe MRI image contrast indicated its promise as highly sensitive hyperpolarized (129)Xe NMR nanoscale biosensor for future applications in cancer detection in vivo.
authors.affiliation: Department of Chemistry, University of California , Berkeley, California 94720-1460, United States.|Materials Sciences Division and §Physical Biosciences Division, Lawrence Berkeley National Laboratory , Berkeley, California 94720-1460, United States.
authors.forename: Keunhong
authors.initials: K
authors.lastname: Jeong
authors.affiliation: Department of Chemistry, University of California , Berkeley, California 94720-1460, United States.|Materials Sciences Division and §Physical Biosciences Division, Lawrence Berkeley National Laboratory , Berkeley, California 94720-1460, United States.
authors.forename: Chawita
authors.initials: C
authors.lastname: Netirojjanakul
authors.affiliation: Department of Chemistry, University of California , Berkeley, California 94720-1460, United States.|Materials Sciences Division and §Physical Biosciences Division, Lawrence Berkeley National Laboratory , Berkeley, California 94720-1460, United States.
authors.forename: Henrik K
authors.initials: HK
authors.lastname: Munch
authors.affiliation: Department of Chemistry, University of California , Berkeley, California 94720-1460, United States.|Materials Sciences Division and §Physical Biosciences Division, Lawrence Berkeley National Laboratory , Berkeley, California 94720-1460, United States.
authors.forename: Jinny
authors.initials: J
authors.lastname: Sun
authors.affiliation: Department of Chemistry, University of California , Berkeley, California 94720-1460, United States.|Materials Sciences Division and §Physical Biosciences Division, Lawrence Berkeley National Laboratory , Berkeley, California 94720-1460, United States.
authors.forename: Joel A
authors.initials: JA
authors.lastname: Finbloom
authors.affiliation: Department of Chemistry, University of California , Berkeley, California 94720-1460, United States.|Materials Sciences Division and §Physical Biosciences Division, Lawrence Berkeley National Laboratory , Berkeley, California 94720-1460, United States.
authors.forename: David E
authors.initials: DE
authors.lastname: Wemmer
authors.affiliation: Department of Chemistry, University of California , Berkeley, California 94720-1460, United States.|Materials Sciences Division and §Physical Biosciences Division, Lawrence Berkeley National Laboratory , Berkeley, California 94720-1460, United States.
authors.forename: Alexander
authors.initials: A
authors.lastname: Pines
authors.affiliation: Department of Chemistry, University of California , Berkeley, California 94720-1460, United States.|Materials Sciences Division and §Physical Biosciences Division, Lawrence Berkeley National Laboratory , Berkeley, California 94720-1460, United States.
authors.forename: Matthew B
authors.initials: MB
authors.lastname: Francis
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry / Q000378:metabolism; D015374:Biosensing Techniques / Q000379:methods*; D002213:Capsid / Q000737:chemistry / Q000378:metabolism; D045744:Cell Line, Tumor; D006801:Humans; D017909:Levivirus; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D057054:Molecular Imaging / Q000379:methods*; D011083:Polycyclic Compounds / Q000737:chemistry; D011487:Protein Conformation
chemical_list: D052157:Aptamers, Nucleotide; D011083:Polycyclic Compounds; C545484:cryptophane A