title: 18F-DOPA PET/CT Physiological Distribution and Pitfalls: Experience in 215 Patients.
abstract: OBJECTIVE
  F-DOPA PET/CT is potentially helpful in the management of patients with low-grade brain tumors, movement disorders, and somatic neuroendocrine tumors. We describe the whole-body physiological distribution of F-DOPA uptake.
  
  
  METHODS
  We examined 215 patients with F-DOPA PET/CT. Among these, 161 had brain scans and 54 had whole-body scans.
  
  
  RESULTS
  Physiological distribution was negligible in the brain, with the exception of basal ganglia, whereas greatest activity was noted in the liver, pancreas, other exocrine glands, and the urinary system. Incidental tracer uptake sites were identified in 5.5% of patients. Some of these findings were due to inflammation, whereas in most cases, uptake was seen in benign tumors of the brain or in the endocrine or exocrine glands.
  
  
  CONCLUSIONS
  F-DOPA uptake may be seen in inflammatory tissue or benign tumors. Correlations with history, physical examination, laboratory examination, CT, MRI, and histology are necessary for optimal diagnosis.
authors.affiliation: From the *Neuroimaging Research Unit, Institute of Molecular Bioimaging and Physiology, IBFM-CNR, Italian National Research Council, Catanzaro; †Department of Biomedicine and Prevention, University "Tor Vergata," Rome; ‡Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila; Departments of §Neuroendocrinology, and ∥Nuclear Medicine and Molecular Imaging, IRCCS Neuromed, Pozzilli, Isernia; ¶Radiation Oncology Unit, Sant' Andrea Hospital, University Sapienza, Rome, and IRCCS Neuromed, Pozzilli (IS), Italy; and **Department of Nuclear Medicine, Santa Maria Della Misericordia Hospital, Rovigo, Italy.
authors.forename: Ferdinando F
authors.initials: FF
authors.lastname: Calabria
authors.forename: Agostino
authors.initials: A
authors.lastname: Chiaravalloti
authors.forename: Marielise L
authors.initials: ML
authors.lastname: Jaffrain-Rea
authors.forename: Maddalena
authors.initials: M
authors.lastname: Zinzi
authors.forename: Pasqualina
authors.initials: P
authors.lastname: Sannino
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Minniti
authors.forename: Domenico
authors.initials: D
authors.lastname: Rubello
authors.forename: Orazio
authors.initials: O
authors.lastname: Schillaci
mesh_terms: D000328:Adult; D000368:Aged; D001692:Biological Transport; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism*; D004295:Dihydroxyphenylalanine / Q000378:metabolism*; D005260:Female; D005462:Fluorine Radioisotopes; D006801:Humans; D008297:Male; D008875:Middle Aged; D000072078:Positron Emission Tomography Computed Tomography; D051598:Whole Body Imaging; D055815:Young Adult
chemical_list: D005462:Fluorine Radioisotopes; D004295:Dihydroxyphenylalanine