title: Therapeutic effect of Colla corii asini on improving anemia and hemoglobin compositions in pregnant women with thalassemia.
abstract: Currently there is no consensus on treating anemia in pregnant thalassemia patients. In China, Colla corii asini (CCA) has been widely used for treating anemia for more than 2000 years. However, its clinical application in the thalassemia population is limited by a lack of quantitative evidence. The present study aims to investigate the therapeutic effect of CCA in increasing hemoglobin (Hb) concentration and improving abnormal hemoglobin compositions in pregnant patients with β-thalassemia. Seventy-two pregnant patients who met inclusion criteria were randomly assigned to either the treatment group or control group. Patients in the treatment group were given 15 g of CCA, while the control group were observed and followed up without any treatment. Levels of Hb, serum iron (SI), serum ferritin (SF) and three types of Hb components [adult hemoglobin (HbA), fetal hemoglobin (HbF), minor adult hemoglobin (HbA2)] were measured before and after treatment. Treatment with CCA led to a significant increase of Hb. The major Hb component induced by CCA was HbA, while levels of both HbA2 and HbF dropped after treatment. CCA treatment significantly increased SI, while SF remained unaffected. Our data suggest that CCA can improve anemia and optimize Hb components in pregnant patients with thalassemia without affecting iron reserves.
authors.affiliation: Department of Obstetrics, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
authors.forename: Yanfang
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Clinical Laboratory, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
authors.forename: Hui
authors.initials: H
authors.lastname: He
authors.affiliation: First School of Clinical Medicine, Guangzhou University of Chinese Medicine, No. 12 Jichang Road, Guangzhou, 510405, Guangdong, China.
authors.forename: Lilin
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Obstetrics, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
authors.forename: Xiangyi
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Obstetrics, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
authors.forename: Daocheng
authors.initials: D
authors.lastname: Li
authors.affiliation: First School of Clinical Medicine, Guangzhou University of Chinese Medicine, No. 12 Jichang Road, Guangzhou, 510405, Guangdong, China. gynspluo@hotmail.com.
authors.forename: Songping
authors.initials: S
authors.lastname: Luo
mesh_terms: D000740:Anemia / Q000097:blood / Q000188:drug therapy*; D005260:Female; D005293:Ferritins / Q000097:blood / Q000187:drug effects; D005319:Fetal Hemoglobin / Q000032:analysis; D005780:Gelatin / Q000494:pharmacology / Q000627:therapeutic use*; D006441:Hemoglobin A / Q000032:analysis; D006443:Hemoglobin A2 / Q000032:analysis; D006454:Hemoglobins / Q000032:analysis / Q000187:drug effects; D006801:Humans; D007501:Iron / Q000097:blood; D011247:Pregnancy; D016896:Treatment Outcome; D017086:beta-Thalassemia / Q000097:blood* / Q000188:drug therapy
chemical_list: D006454:Hemoglobins; C000612945:colla corii asini; D005780:Gelatin; D005293:Ferritins; D006441:Hemoglobin A; D006443:Hemoglobin A2; D005319:Fetal Hemoglobin; D007501:Iron
keywords: Anemia; Colla corii asini; Hemoglobin; Pregnancy; Thalassemia