title: Poly(lactic acid) based hydrogels.
abstract: Polylactide (PLA) and its copolymers are hydrophobic polyesters used for biomedical applications. Hydrogel medicinal implants have been used as drug delivery vehicles and scaffolds for tissue engineering, tissue augmentation and more. Since lactides are non-functional, they are copolymerized with hydrophilic monomers or conjugated to a hydrophilic moiety to form hydrogels. Copolymers of lactic and glycolic acids with poly(ethylene glycol) (PEG) provide thermo-responsive hydrogels. Physical crosslinking mechanisms of PEG-PLA or PLA-polysaccharides include: lactic acid segment hydrophobic interactions, stereocomplexation of D and L-lactic acid segments, ionic interactions, and chemical bond formation by radical or photo crosslinking. These hydrogels may also be tailored as stimulus responsive (pH, photo, or redox). PLA and its copolymers have also been polymerized to include urethane bonds to fabricate shape memory hydrogels. This review focuses on the synthesis, characterization, and applications of PLA containing hydrogels.
authors.affiliation: School of Pharmacy-Faculty of Medicine, The Hebrew University of Jerusalem, and Jerusalem College of Engineering (JCE), Jerusalem 91120, Israel. Electronic address: arijitb@ekmd.huji.ac.il.
authors.forename: Arijit
authors.initials: A
authors.lastname: Basu
authors.affiliation: School of Pharmacy-Faculty of Medicine, The Hebrew University of Jerusalem, and Jerusalem College of Engineering (JCE), Jerusalem 91120, Israel.
authors.forename: Konda Reddy
authors.initials: KR
authors.lastname: Kunduru
authors.affiliation: Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500037, India.
authors.forename: Sindhu
authors.initials: S
authors.lastname: Doppalapudi
authors.affiliation: School of Pharmacy-Faculty of Medicine, The Hebrew University of Jerusalem, and Jerusalem College of Engineering (JCE), Jerusalem 91120, Israel. Electronic address: avid@ekmd.huji.ac.il.
authors.forename: Abraham J
authors.initials: AJ
authors.lastname: Domb
authors.affiliation: Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500037, India.
authors.forename: Wahid
authors.initials: W
authors.lastname: Khan
mesh_terms: D000818:Animals; D006801:Humans; D020100:Hydrogels / Q000138:chemical synthesis* / Q000737:chemistry* / Q000528:radiation effects; D019344:Lactic Acid / Q000737:chemistry; D011091:Polyesters / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D013696:Temperature
chemical_list: D020100:Hydrogels; D011091:Polyesters; C542623:monomethoxypolyethyleneglycol-polylactide block copolymer; D019344:Lactic Acid; D011092:Polyethylene Glycols; C033616:poly(lactide)
keywords: Hydrogel; In situ hydrogel; PLA; PLA–PEG; Responsive polymer; Thermo-responsive