title: Cu(I) complexes of bis(methyl)(thia/selena) salen ligands: Synthesis, characterization, redox behavior and DNA binding studies.
abstract: Mononuclear cuprous complexes 1 and 2, [{CH3E(o-C6H4)CH=NCH2}2Cu]ClO4; E=S/Se, have been synthesized by the reaction of bis(methyl)(thia/selena) salen ligands and [Cu(CH3CN)4]ClO4. Both the products were characterized by elemental analysis, ESI-MS, FT-IR,1H/13C/77Se NMR, and cyclic voltammetry. The complexes possess tetrahedral geometry around metal center with the N2S2/N2Se2coordination core. Cyclic voltammograms of complexes 1 and 2 displayed reversible anodic waves at E1/2=+0.08V and +0.10V, respectively, corresponding to the Cu(I)/Cu(II) redox couple. DNA binding studies of both the complexes were performed applying absorbance, fluorescence and molecular docking techniques. Competitive binding experiment of complexes with ct-DNA against ethidium bromide is performed to predict the mode of binding. The results indicate the groove binding mode of complexes 1 and 2 to DNA. The binding constants revealed the strong binding affinity of complexes towards ct-DNA.
authors.affiliation: Department of Chemical Sciences, Indian Institute of Science Education and Research, Kolkata, Mohanpur, 741252 Nadia, WB, India. Electronic address: ashu.asatkar@gmail.com.
authors.forename: Ashish K
authors.initials: AK
authors.lastname: Asatkar
authors.affiliation: School of Studies in Chemistry, Pt. Ravishankar Shukla University, Raipur 492010, India.
authors.forename: Mamta
authors.initials: M
authors.lastname: Tripathi
authors.affiliation: Department of Chemical Sciences, Indian Institute of Science Education and Research, Kolkata, Mohanpur, 741252 Nadia, WB, India.
authors.forename: Snigdha
authors.initials: S
authors.lastname: Panda
authors.affiliation: School of Studies in Chemistry, Pt. Ravishankar Shukla University, Raipur 492010, India.
authors.forename: Rama
authors.initials: R
authors.lastname: Pande
authors.affiliation: Department of Chemical Sciences, Indian Institute of Science Education and Research, Kolkata, Mohanpur, 741252 Nadia, WB, India.
authors.forename: Sanjio S
authors.initials: SS
authors.lastname: Zade
mesh_terms: D000818:Animals; D002417:Cattle; D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D004563:Electrochemistry; D004996:Ethidium / Q000737:chemistry; D008024:Ligands; D008968:Molecular Conformation; D062105:Molecular Docking Simulation; D009942:Organometallic Compounds / Q000138:chemical synthesis*; D010084:Oxidation-Reduction; D013050:Spectrometry, Fluorescence
chemical_list: D008024:Ligands; D009942:Organometallic Compounds; D003300:Copper; D004247:DNA; C427203:calf thymus DNA; D004996:Ethidium
keywords: Cu(I) complexes; Cyclic voltammetry; DNA binding; Thia/selena-salen