title: The contribution of lesion location to upper limb deficit after stroke.
abstract: Motor deficit after stroke is related to regional anatomical damage.
  
  
  
  To examine the influence of lesion location on upper limb motor deficit in chronic patients with stroke.
  
  
  
  Lesion likelihood maps were created from T1-weighted structural MRI in 33 chronic patients with stroke with either purely subcortical lesions (SC, n=19) or lesions extending to any of the cortical motor areas (CM, n=14). We estimated lesion likelihood maps over the whole brain and applied multivoxel pattern analysis to seek the contribution weight of lesion likelihood to upper limb motor deficit. Among 5 brain regions of interest, the brain region with the greatest contribution to motor deficit was determined for each subgroup.
  
  
  
  The corticospinal tract was most likely to be damaged in both subgroups. However, while damage in the corticospinal tract was the best indicator of motor deficit in the SC patients, motor deficit in the CM patients was best explained by damage in brain areas activated during handgrip.
  
  
  
  Quantification of structural damage can add to models explaining motor outcome after stroke, but assessment of corticospinal tract damage alone is unlikely to be sufficient when considering patients with stroke with a wide range of lesion topography.
authors.affiliation: Sobell Department of Motor Neuroscience, UCL Institute of Neurology, London, UK.|Department of Neurology, Ewha Medical Research Institute, Ewha Womans University School of Medicine, Seoul, Korea.
authors.forename: Chang-Hyun
authors.initials: CH
authors.lastname: Park
authors.affiliation: Sobell Department of Motor Neuroscience, UCL Institute of Neurology, London, UK.
authors.forename: Nancy
authors.initials: N
authors.lastname: Kou
authors.affiliation: Sobell Department of Motor Neuroscience, UCL Institute of Neurology, London, UK.|The National Hospital for Neurology and Neurosurgery, London, UK.|UCLPartners Centre for Neurorehabilitation, UCL Institute of Neurology, London, UK.
authors.forename: Nick S
authors.initials: NS
authors.lastname: Ward
mesh_terms: D000368:Aged; D001072:Apraxias / Q000000981:diagnostic imaging* / Q000209:etiology*; D001132:Arm / Q000294:innervation*; D001921:Brain / Q000000981:diagnostic imaging*; D001931:Brain Mapping; D002544:Cerebral Infarction / Q000150:complications* / Q000000981:diagnostic imaging*; D002908:Chronic Disease; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000000981:diagnostic imaging; D009460:Neurologic Examination; D011712:Pyramidal Tracts / Q000000981:diagnostic imaging
keywords: ANATOMY; IMAGE ANALYSIS; MRI; STROKE