title: Prolyl carboxypeptidase purified from human placenta: its characterization and identification as an apelin-cleaving enzyme.
authors.affiliation: Laboratory of Medical Biochemistry, Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium. Electronic address: kaat.kehoe@uantwerpen.be.
authors.forename: Kaat
authors.initials: K
authors.lastname: Kehoe
authors.affiliation: Laboratory of Medical Biochemistry, Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium.
authors.forename: Roos
authors.initials: R
authors.lastname: Van Elzen
authors.affiliation: Laboratory of Medical Biochemistry, Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium.
authors.forename: Robert
authors.initials: R
authors.lastname: Verkerk
authors.affiliation: Laboratory of Medical Biochemistry, Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium.
authors.forename: Yani
authors.initials: Y
authors.lastname: Sim
authors.affiliation: Laboratory of Medicinal Chemistry, Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium.
authors.forename: Pieter
authors.initials: P
authors.lastname: Van der Veken
authors.affiliation: Laboratory of Medical Biochemistry, Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium.
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Lambeir
authors.affiliation: Laboratory of Medical Biochemistry, Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium.
authors.forename: Ingrid
authors.initials: I
authors.lastname: De Meester
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000073861:Apelin; D002268:Carboxypeptidases / Q000737:chemistry* / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism; D003089:Colipases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D004734:Energy Metabolism / Q000235:genetics; D004792:Enzyme Precursors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D005260:Female; D015870:Gene Expression; D054439:Ghrelin / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D007700:Kinetics; D010920:Placenta / Q000737:chemistry* / Q000201:enzymology; D011247:Pregnancy; D059748:Proteolysis; D013379:Substrate Specificity; D000521:alpha-MSH / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism
chemical_list: C115436:APLN protein, human; D000073861:Apelin; D003089:Colipases; D004792:Enzyme Precursors; D054439:Ghrelin; D036341:Intercellular Signaling Peptides and Proteins; C505799:obestatin, human; D000521:alpha-MSH; C037107:procolipase; D002268:Carboxypeptidases
keywords: (Pyr)-apelin-13; Energy homeostasis; Enzyme kinetics; Prolyl carboxypeptidase; Substrate specificity