title: Anosognosia in Dementia.
abstract: Progressive decline in memory (and other functions) is the defining feature of late-life dementia but affected individuals are often unaware of this impairment. This article reviews recent research on anosognosia in dementia, including methods of assessing anosognosia, its prevalence and developmental course in dementia, its occurrence in different forms of dementia, neuroimaging findings, and hypothesized component mechanisms. The results suggest that anosognosia is eventually exhibited by nearly all persons with dementia. Its occurrence is robustly associated with common dementia-related pathologies and damage to memory and self-referential brain networks and their interconnections.
authors.affiliation: Rush Alzheimer's Disease Center, Rush University Medical Center, 600 South Paulina Street, Chicago, IL, 60612, USA. rwilson@rush.edu.|Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA. rwilson@rush.edu.|Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA. rwilson@rush.edu.
authors.forename: Robert S
authors.initials: RS
authors.lastname: Wilson
authors.affiliation: Rush Alzheimer's Disease Center, Rush University Medical Center, 600 South Paulina Street, Chicago, IL, 60612, USA.
authors.forename: Joel
authors.initials: J
authors.lastname: Sytsma
authors.affiliation: Rush Alzheimer's Disease Center, Rush University Medical Center, 600 South Paulina Street, Chicago, IL, 60612, USA.|Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.|Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA.
authors.forename: Lisa L
authors.initials: LL
authors.lastname: Barnes
authors.affiliation: Rush Alzheimer's Disease Center, Rush University Medical Center, 600 South Paulina Street, Chicago, IL, 60612, USA.|Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA.
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Boyle
mesh_terms: D000377:Agnosia / Q000209:etiology*; D001364:Awareness; D003704:Dementia / Q000150:complications*; D006801:Humans; D008568:Memory; D009483:Neuropsychological Tests
keywords: Anosognosia; Dementia; Frontotemporal dementia; Memory awareness; Metacognition; Subjective memory