title: [Strategies of age-adapted pharmacotherapy in renal failure].
abstract: Many geriatric patients with multimorbidities have an increased risk for impaired renal function due to age and often the presence of comorbidities, such as diabetes mellitus, hypertension and heart failure. This impairment in kidney function in turn necessitates adjustments in drug therapy. A successful strategy for treating these patients includes treatment of the underlying diseases, a comprehensive review of the indications, selection of appropriate pharmacotherapeutic alternatives and for some drugs dose adjustment to the renal function. To achieve therapeutic success many patient individual factors, such as potentially complex medication regimens, polypharmacy, cognitive function and functional disabilities need to be considered when prescribing medications. This article describes the problems associated with drug therapy that is not adjusted to renal function and provides guidelines for assessment of the benefits and risks in patients with kidney failure. The characteristic features of geriatric patients in particular are considered and discussed.
authors.affiliation: Krankenhausapotheke, Uniklinik Köln, Gleueler Str. 88, 50937, Köln, Deutschland. rebekka.lenssen@uk-koeln.de.
authors.forename: R
authors.initials: R
authors.lastname: Lenssen
authors.affiliation: Krankenhausapotheke, Uniklinik Köln, Gleueler Str. 88, 50937, Köln, Deutschland. andrea.liekweg@uk-koeln.de.
authors.forename: A
authors.initials: A
authors.lastname: Liekweg
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D016903:Drug Monitoring / Q000379:methods; D019317:Evidence-Based Medicine; D005260:Female; D015577:Geriatric Assessment / Q000379:methods; D005858:Germany; D006801:Humans; D007674:Kidney Diseases / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D008297:Male; D019338:Polypharmacy; D012076:Renal Agents / Q000008:administration & dosage* / Q000009:adverse effects*; D051437:Renal Insufficiency / Q000175:diagnosis* / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D012076:Renal Agents
keywords: Age; Dose adjustment; Geriatrics; Impaired renal function; Polypharmacy