title: Recent Advances in Substrate-Controlled Asymmetric Induction Derived from Chiral Pool α-Amino Acids for Natural Product Synthesis.
abstract: Chiral pool α-amino acids have been used as powerful tools for the total synthesis of structurally diverse natural products. Some common naturally occurring α-amino acids are readily available in both enantiomerically pure forms. The applications of the chiral pool in asymmetric synthesis can be categorized prudently as chiral sources, devices, and inducers. This review specifically examines recent advances in substrate-controlled asymmetric reactions induced by the chirality of α-amino acid templates in natural product synthesis research and related areas.
authors.affiliation: College of Pharmacy, Research Institute of Pharmaceutical Science, Gyeongsang National University, Jinju daero, Jinju 52828, Korea. million@gnu.ac.kr.
authors.forename: Seung-Mann
authors.initials: SM
authors.lastname: Paek
authors.affiliation: College of Pharmacy, Pusan National University, Busan 46241, Korea. navy7750@gmail.com.
authors.forename: Myeonggyo
authors.initials: M
authors.lastname: Jeong
authors.affiliation: College of Pharmacy, Pusan National University, Busan 46241, Korea. jju02160@gmail.com.
authors.forename: Jeyun
authors.initials: J
authors.lastname: Jo
authors.affiliation: College of Pharmacy, Research Institute of Pharmaceutical Science, Gyeongsang National University, Jinju daero, Jinju 52828, Korea. yumiizzi11@naver.com.
authors.forename: Yu Mi
authors.initials: YM
authors.lastname: Heo
authors.affiliation: College of Pharmacy, Dankook University, Cheonan 31116, Korea. hanyt@dankook.ac.kr.
authors.forename: Young Taek
authors.initials: YT
authors.lastname: Han
authors.affiliation: College of Pharmacy, Pusan National University, Busan 46241, Korea. hyun@pusan.ac.kr.
authors.forename: Hwayoung
authors.initials: H
authors.lastname: Yun
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D061565:Cycloaddition Reaction; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D001688:Biological Products
keywords: asymmetric induction; chiral pool; natural product; total synthesis; α-amino acid