title: HIV and decreased risk of multiple sclerosis: role of low CD4+ lymphocyte count and male prevalence.
abstract: In this retrospective case-control study, we compared the number of circulating lymphocyte subsets among 31 healthy controls, 18 naïve and 40 antiretroviral-treated HIV patients, 28 untreated and 18 treated relapsing-remitting multiple sclerosis (MS) patients. Lymphocyte subsets were no different between untreated MS patients and controls. Untreated and treated MS had a lower CD8+ count and a higher CD4+ number compared to untreated and treated HIV patients except similar CD4+ number between treated MS and HIV patients. CD4/CD8 ratio was lower in female HIV non-responders and in relapsing MS women compared, respectively, to female HIV responders and remitting MS women, and there were no differences in men.
authors.affiliation: Multiple Sclerosis Clinical and Research Unit, Department of Systems Medicine, Tor Vergata University, Via Montpellier 1, 00133, Rome, Italy. tatiana.koud@gmail.com.|Neuroncology, Regina Elena National Cancer Institute, IFO, Via Elio Chianesi 53, 00144, Rome, Italy. tatiana.koud@gmail.com.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Koudriavtseva
authors.affiliation: Neuroncology, Regina Elena National Cancer Institute, IFO, Via Elio Chianesi 53, 00144, Rome, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Plantone
authors.affiliation: Clinical Pathology, Regina Elena National Cancer Institute, IFO, Via Elio Chianesi 53, 00144, Rome, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Mandoj
authors.affiliation: Biostatistics Unit, Regina Elena National Cancer Institute, IFO, Via Elio Chianesi 53, 00144, Rome, Italy.
authors.forename: Diana
authors.initials: D
authors.lastname: Giannarelli
authors.affiliation: Infectious Dermatology and Allergology Unit, S. Gallicano Dermatological Institute, IFO, Via Elio Chianesi 53, 00144, Rome, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Latini
authors.affiliation: Infectious Dermatology and Allergology Unit, S. Gallicano Dermatological Institute, IFO, Via Elio Chianesi 53, 00144, Rome, Italy.
authors.forename: Manuela
authors.initials: M
authors.lastname: Colafigli
authors.affiliation: Clinical Pathology and Microbiology, San Gallicano Dermatological Institute, IFO, Via Elio Chianesi 53, 00144, Rome, Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Trento
authors.affiliation: Clinical Pathology and Microbiology, San Gallicano Dermatological Institute, IFO, Via Elio Chianesi 53, 00144, Rome, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Cordiali-Fei
authors.affiliation: Clinical Pathology and Microbiology, San Gallicano Dermatological Institute, IFO, Via Elio Chianesi 53, 00144, Rome, Italy.
authors.forename: Fulvia
authors.initials: F
authors.lastname: Pimpinelli
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D015415:Biomarkers / Q000032:analysis; D018791:CD4 Lymphocyte Count; D016516:CD4-CD8 Ratio; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology; D016022:Case-Control Studies; D005260:Female; D000068717:Glatiramer Acetate / Q000627:therapeutic use; D015658:HIV Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology / Q000821:virology; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D016130:Immunophenotyping; D016899:Interferon-beta / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology / Q000821:virology; D011379:Prognosis; D012189:Retrospective Studies; D012737:Sex Factors; D019562:Viral Load / Q000187:drug effects
chemical_list: D019380:Anti-HIV Agents; D015415:Biomarkers; D007155:Immunologic Factors; D000068717:Glatiramer Acetate; D016899:Interferon-beta
keywords: CD4+ count; HIV positive dermatological patients; Multiple Sclerosis; circulating lymphocytes; gender