title: Injectable and Glucose-Responsive Hydrogels Based on Boronic Acid-Glucose Complexation.
abstract: Injectable hydrogels have been widely used for a number of biomedical applications. Here, we report a new strategy to form an injectable and glucose-responsive hydrogel using the boronic acid-glucose complexation. The ratio of boronic acid and glucose functional groups is critical for hydrogel formation. In our system, polymers with 10-60% boronic acid, with the balance being glucose-modified, are favorable to form hydrogels. These hydrogels are shear-thinning and self-healing, recovering from shear-induced flow to a gel state within seconds. More importantly, these polymers displayed glucose-responsive release of an encapsulated model drug. The hydrogel reported here is an injectable and glucose-responsive hydrogel constructed from the complexation of boronic acid and glucose within a single component polymeric material.
authors.affiliation: Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University , Columbus, Ohio 43210, United States.
authors.forename: Yizhou
authors.initials: Y
authors.lastname: Dong
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.|Department of Anesthesiology, Children's Hospital Boston, Harvard Medical School , Boston, Massachusetts 02115, United States.
authors.forename: Weiheng
authors.initials: W
authors.lastname: Wang
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.|Department of Chemical Engineering, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.|Department of Anesthesiology, Children's Hospital Boston, Harvard Medical School , Boston, Massachusetts 02115, United States.
authors.forename: Omid
authors.initials: O
authors.lastname: Veiseh
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.
authors.forename: Eric A
authors.initials: EA
authors.lastname: Appel
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.|Department of Biology, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.
authors.forename: Kun
authors.initials: K
authors.lastname: Xue
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.|Department of Anesthesiology, Children's Hospital Boston, Harvard Medical School , Boston, Massachusetts 02115, United States.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Webber
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.|Department of Anesthesiology, Children's Hospital Boston, Harvard Medical School , Boston, Massachusetts 02115, United States.
authors.forename: Benjamin C
authors.initials: BC
authors.lastname: Tang
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.
authors.forename: Xi-Wen
authors.initials: XW
authors.lastname: Yang
authors.affiliation: Section on Islet Cell and Regenerative Biology, Research Division, Joslin Diabetes Center , One Joslin Place, Boston, Massachusetts 02215, United States.
authors.forename: Gordon C
authors.initials: GC
authors.lastname: Weir
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.|Department of Chemical Engineering, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.|Department of Anesthesiology, Children's Hospital Boston, Harvard Medical School , Boston, Massachusetts 02115, United States.|Institute for Medical Engineering and Science, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.
authors.forename: Robert
authors.initials: R
authors.lastname: Langer
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.|Department of Chemical Engineering, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.|Department of Anesthesiology, Children's Hospital Boston, Harvard Medical School , Boston, Massachusetts 02115, United States.|Institute for Medical Engineering and Science, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.
authors.forename: Daniel G
authors.initials: DG
authors.lastname: Anderson
mesh_terms: D001897:Boronic Acids / Q000737:chemistry*; D065546:Drug Liberation; D005456:Fluorescent Dyes / Q000737:chemistry; D005947:Glucose / Q000737:chemistry*; D020100:Hydrogels / Q000138:chemical synthesis / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007267:Injections; D007700:Kinetics; D058105:Polymerization; D012212:Rheology; D012235:Rhodamines / Q000737:chemistry
chemical_list: D001897:Boronic Acids; D005456:Fluorescent Dyes; D020100:Hydrogels; D012235:Rhodamines; D005947:Glucose; C029773:rhodamine B