title: Cytokines and cell adhesion molecules exhibit distinct profiles in health, ovarian cancer, and breast cancer.
abstract: OBJECTIVE
  We examined a panel of cytokines and cell adhesion molecules in an attempt to identify cancer specific profiles.
  
  
  METHODS
  Cytokines and cell adhesion arrays (Randox Ltd.) were measured in samples from women with a histological diagnosis of ovarian cancer ([Formula: see text]) or breast cancer ([Formula: see text]) or cancer free ([Formula: see text]). Random forest analysis was used for classification.
  
  
  RESULTS
  Ovarian cancer subjects were classified with a sensitivity of 85.7% (95% CI 50-100) and a specificity of 84.2% (95% CI 69.4-93.4). Breast cancer subjects were classified with a sensitivity of 70.8% (95% CI 47.1-86.4) and a specificity of 96.4% (95% CI 82.1-100).
  
  
  CONCLUSIONS
  Cytokine and cell adhesion molecule profiles provide additional information that may be useful for cancer characterization of female cancers.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, Canada.
authors.forename: Matthew P A
authors.initials: MP
authors.lastname: Henderson
authors.affiliation: Juravinski Cancer Centre, Medical Oncology, Hamilton Ontario, Canada.
authors.forename: Holger
authors.initials: H
authors.lastname: Hirte
authors.affiliation: Juravinski Cancer Centre, Medical Oncology, Hamilton Ontario, Canada.
authors.forename: Sebastien J
authors.initials: SJ
authors.lastname: Hotte
authors.affiliation: Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Kavsak
keywords: Cancer diagnostics; Laboratory medicine; Medical informatics; Statistics