title: Approaches for enantioselective resolution of pharmaceuticals by miniaturised separation techniques with new chiral phases based on nanoparticles and monolithis.
abstract: This article discusses new developments in the preparation of nanoparticles and monoliths with emphasis upon their application as the stationary and pseudo-stationary phases for miniaturised liquid phase separation techniques, which have occurred in the last 10 years (from 2006 to the actuality). References included in this review represent current trends and state of the art in the application of these materials to the analysis, by EKC, CEC and miniaturised chromatography, of chiral compounds with environmental interest such as pharmaceuticals. Due to their extraordinary properties, columns prepared with these new chiral stationary or pseudo-stationary phases, based on materials such as gold nanoparticles, metal-organic frameworks, ordered mesoporous silicas, carbonaceous materials, polymeric-based and silica-based monoliths or molecularly imprinted materials, can usually show some improvements in the separation selectivity, column efficiency and chemical stability in comparison with conventional chiral columns available commercially.
authors.affiliation: Departamento de Tecnología Química y Energética, Tecnología Química y Ambiental, Tecnología Mecánica y Química Analítica, ESCET, Universidad Rey Juan Carlos, C/ Tulipán s/n, Móstoles, Madrid, Spain. isabel.sierra@urjc.es.
authors.forename: Isabel
authors.initials: I
authors.lastname: Sierra
authors.affiliation: Departamento de Química Analítica, Química Física e Ingeniería Química, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain.
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Marina
authors.affiliation: Departamento de Tecnología Química y Energética, Tecnología Química y Ambiental, Tecnología Mecánica y Química Analítica, ESCET, Universidad Rey Juan Carlos, C/ Tulipán s/n, Móstoles, Madrid, Spain.
authors.forename: Damián
authors.initials: D
authors.lastname: Pérez-Quintanilla
authors.affiliation: Departamento de Tecnología Química y Energética, Tecnología Química y Ambiental, Tecnología Mecánica y Química Analítica, ESCET, Universidad Rey Juan Carlos, C/ Tulipán s/n, Móstoles, Madrid, Spain.
authors.forename: Sonia
authors.initials: S
authors.lastname: Morante-Zarcero
authors.affiliation: Departamento de Tecnología Química y Energética, Tecnología Química y Ambiental, Tecnología Mecánica y Química Analítica, ESCET, Universidad Rey Juan Carlos, C/ Tulipán s/n, Móstoles, Madrid, Spain.
authors.forename: Mariana
authors.initials: M
authors.lastname: Silva
mesh_terms: D053801:Capillary Electrochromatography / Q000379:methods*; D020374:Chromatography, Micellar Electrokinetic Capillary / Q000379:methods*; D008904:Miniaturization / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry; D036103:Nanotechnology / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification; D012822:Silicon Dioxide / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D004364:Pharmaceutical Preparations; D012822:Silicon Dioxide
keywords: Chiral analysis; Miniaturised separation techniques; Monoliths; Nanoparticles; Pharmaceuticals