title: Dendritic cells as gatekeepers of tolerance.
abstract: Dendritic cells (DC) are unique hematopoietic cells, linking innate and adaptive immune responses. In particular, they are considered as the most potent antigen presenting cells, governing both T cell immunity and tolerance. In view of their exceptional ability to present antigen and to interact with T cells, DC play distinct roles in shaping T cell development, differentiation and function. The outcome of the DC-T cell interaction is determined by the state of DC maturation, the type of DC subset, the cytokine microenvironment and the tissue location. Both regulatory T cells (Tregs) and DC are indispensable for maintaining central and peripheral tolerance. Over the past decade, accumulating data indicate that DC critically contribute to Treg differentiation and homeostasis.
authors.affiliation: Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany. waisman@uni-mainz.de.
authors.forename: Ari
authors.identifier: 0000-0003-4304-8234
authors.initials: A
authors.lastname: Waisman
authors.affiliation: Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.|Department of Microbiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
authors.forename: Dominika
authors.initials: D
authors.lastname: Lukas
authors.affiliation: Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
authors.forename: Björn E
authors.initials: BE
authors.lastname: Clausen
authors.affiliation: Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.|Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
authors.forename: Nir
authors.initials: N
authors.lastname: Yogev
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology / Q000378:metabolism / Q000628:therapy; D015415:Biomarkers; D002450:Cell Communication; D002454:Cell Differentiation; D003713:Dendritic Cells / Q000145:classification / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D007108:Immune Tolerance; D007167:Immunotherapy; D009928:Organ Specificity / Q000276:immunology; D010641:Phenotype; D015398:Signal Transduction; D016176:T-Lymphocyte Subsets
chemical_list: D015415:Biomarkers
keywords: Dendritic cells; Regulatory T cells; Tolerance induction