title: Preventive effect of Gardenia jasminoides on HCl/ethanol induced gastric injury in mice.
abstract: The therapeutic effect on HCl/ethanol induced gastric injury of Gardenia jasminoides (JXGJ-1 and JXGJ-2) were determined by a animal model. JXGJ-2 group reduced area of its gastric injury as compared to the control group, JXGJ-2 also helped in decreasing the gastric secretion volume results raised in pH value. The NO contents in serum, heart, liver, kidney and stomach of JXGJ-2 group were more than JXGJ-1 and control groups. JXGJ-2 reduce cytokine levels as compared to JXGJ-1 and control group. The serum and gastric tissue SOD, GSH-Px, GSH levels in JXGJ-2 treated mice were higher than JXGJ-1 treated and control mice, but the MDA, PC levels showed the crosscurrents, these levels were close to normal mice. Gardenia jasminoides could increase the occludin, EGF, EGFR, VEGF, IκB-α, nNOS, eNOS, Cu/Zn-SOD, Mn-SOD, CAT, GSH-Px (GSH1) mRNA and protein expressions and decrease the p38MAPK (p38), NF-κB, Bcl-2, COX-2, iNOS expressions in gastric tissues unlike to the control mice, JXGJ-2 had much better effect than JXGJ-1. JXGJ-1contained the higher genipin gentiobioside and gardenoside, they might be the key components of gastric injury inhibition. Gardenia jasminoides had a remarkable effect on gastric injury, and they were derived from two important components of genipin gentiobioside and gardenoside.
authors.affiliation: Department of Biological and Chemical Engineering, Chongqing University of Education, Chongqing 400067, China; Chongqing Collaborative Innovation Center of Functional Food, Chongqing University of Education, Chongqing 400067, China; Chongqing Engineering Technology Research Center for Functional Food, Chongqing University of Education, Chongqing 400067, China.
authors.forename: Shaocheng
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Biological and Chemical Engineering, Chongqing University of Education, Chongqing 400067, China; Chongqing Collaborative Innovation Center of Functional Food, Chongqing University of Education, Chongqing 400067, China; Chongqing Engineering Technology Research Center for Functional Food, Chongqing University of Education, Chongqing 400067, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Biological and Chemical Engineering, Chongqing University of Education, Chongqing 400067, China; Chongqing Collaborative Innovation Center of Functional Food, Chongqing University of Education, Chongqing 400067, China; Chongqing Engineering Technology Research Center for Functional Food, Chongqing University of Education, Chongqing 400067, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Sun
authors.affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201210, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Qian
authors.affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201210, China; Chongqing Three Gorges Natural Medicine Research Institute, Chongqing 404000, China. Electronic address: yhs_lucky@163.com.
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Shi
authors.affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201210, China. Electronic address: wangelle@hotmail.com.
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology; D000431:Ethanol / Q000009:adverse effects*; D032062:Gardenia / Q000737:chemistry*; D006851:Hydrochloric Acid / Q000009:adverse effects*; D039823:Iridoids / Q000494:pharmacology*; D008297:Male; D051379:Mice; D013270:Stomach / Q000187:drug effects* / Q000473:pathology; D013272:Stomach Diseases / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*
chemical_list: D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D039823:Iridoids; D000431:Ethanol; C007834:genipin; C056587:gardenoside; D006851:Hydrochloric Acid
keywords: Ethanol; Expression; Gastric injury; Geniposide; Lactobacillus casei Qian