title: [Patterns of ocular neurovascular reactions].
abstract: OBJECTIVE
  To examine factors and determinants of ocular neurovascular reactions (NVR).
  
  
  METHODS
  The study included 120 healthy participants of both sexes aged 20.9±0.6 years, who underwent a standard ophthalmic examination. Ocular microcirculation was recorded using laser Doppler flowmetry. Autonomic homeostasis and the intensity of slow-wave oscillations of hemodynamics were of interest. Autoregulation of cerebral blood flow was assessed by transcranial color-coded duplex scanning.
  
  
  RESULTS
  The dynamics of perfusion control mechanisms (myogenic and neurogenic) have been studied in the young healthy population of Krasnoyarsk. The role of the autonomic nervous system in initiating a particular type of ocular NVR has been identified. The authors have also determined the significance of the nitric oxide production intensity in different types of NVR.
  
  
  CONCLUSIONS
  The type of ocular NVR is determined by parameters of cerebral hemodynamics. Normotonic NVR is associated with effective autoregulation of cerebral blood flow, while hyper- and hypotonic types of reactions - with autoregulatory failure.
authors.affiliation: Krasnoyarsk State Medical University named after prof. V.F. Voyno-Yasenetsky, 1 Partizana Zeleznyaka St., Krasnoyarsk, Russian Federation, 660022.
authors.forename: V I
authors.initials: VI
authors.lastname: Lazarenko
authors.affiliation: Krasnoyarsk regional ophthalmological clinical hospital named after prof. P.G. Makarov, 1v Nikitina St., Krasnoyarsk, Russian Federation, 660022.
authors.forename: A S
authors.initials: AS
authors.lastname: Kadantseva
authors.affiliation: Krasnoyarsk State Medical University named after prof. V.F. Voyno-Yasenetsky, 1 Partizana Zeleznyaka St., Krasnoyarsk, Russian Federation, 660022.
authors.forename: Yu I
authors.initials: YI
authors.lastname: Savchenkov
authors.affiliation: Krasnoyarsk State Medical University named after prof. V.F. Voyno-Yasenetsky, 1 Partizana Zeleznyaka St., Krasnoyarsk, Russian Federation, 660022.
authors.forename: R I
authors.initials: RI
authors.lastname: Shatilova
mesh_terms: D001341:Autonomic Nervous System / Q000502:physiology; D001921:Brain / Q000098:blood supply*; D005123:Eye / Q000098:blood supply / Q000294:innervation; D005260:Female; D064368:Healthy Volunteers; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D017078:Laser-Doppler Flowmetry / Q000379:methods; D008297:Male; D008833:Microcirculation / Q000502:physiology*; D000069336:Neurovascular Coupling / Q000502:physiology*; D009569:Nitric Oxide / Q000378:metabolism; D009991:Oscillometry / Q000379:methods; D017585:Ultrasonography, Doppler, Transcranial / Q000379:methods; D055815:Young Adult
chemical_list: D009569:Nitric Oxide