title: Congenital and perinatally-acquired infections in resource-constrained settings.
abstract: Congenital and perinatal infections are a leading cause of neonatal and infant morbidity and mortality. Maternal screening, vaccines or treatment where available, constitute effective prevention strategies to reduce the burden of these diseases. Data on the burden of congenital and perinatal infections are very limited for low and middle-income regions.
  
  
  
  This review aims to summarize the burden of congenital and perinatal infections and the main challenges for their control in resource-limited settings. Articles were identified through the main electronic databases and cover the period 1971-2016. Expert commentary: Estimates from low and middle-income countries indicate that the burden of congenital infections may be higher in these regions than in industrialized countries. As preventive and curative strategies are available to tackle some of these infections, efforts at the international and national levels must be made to implement those and thus reduce their burden in resource-limited countries.
authors.affiliation: a Centro de Investigação em Saúde de Manhiça (CISM) , Maputo , Mozambique.|b ISGlobal, Barcelona Ctr. Int. Health Res. (CRESIB) , Hospital Clínic - Universitat de Barcelona , Barcelona , Spain.
authors.forename: Lola
authors.initials: L
authors.lastname: Madrid
authors.affiliation: a Centro de Investigação em Saúde de Manhiça (CISM) , Maputo , Mozambique.|b ISGlobal, Barcelona Ctr. Int. Health Res. (CRESIB) , Hospital Clínic - Universitat de Barcelona , Barcelona , Spain.
authors.forename: Rosauro
authors.initials: R
authors.lastname: Varo
authors.affiliation: a Centro de Investigação em Saúde de Manhiça (CISM) , Maputo , Mozambique.
authors.forename: Antonio
authors.initials: A
authors.lastname: Sitoe
authors.affiliation: a Centro de Investigação em Saúde de Manhiça (CISM) , Maputo , Mozambique.|b ISGlobal, Barcelona Ctr. Int. Health Res. (CRESIB) , Hospital Clínic - Universitat de Barcelona , Barcelona , Spain.
authors.forename: Quique
authors.initials: Q
authors.lastname: Bassat
mesh_terms: D003586:Cytomegalovirus Infections / Q000151:congenital / Q000517:prevention & control; D003906:Developing Countries; D005260:Female; D006561:Herpes Simplex / Q000151:congenital / Q000517:prevention & control; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D018743:Perinatal Care; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology / Q000469:parasitology / Q000821:virology; D011296:Prenatal Diagnosis; D012410:Rubella Syndrome, Congenital / Q000175:diagnosis / Q000517:prevention & control; D013590:Syphilis, Congenital / Q000175:diagnosis / Q000517:prevention & control; D014125:Toxoplasmosis, Congenital / Q000175:diagnosis / Q000517:prevention & control
keywords: TORCH; congenital infections; congenital syphilis; congenital toxoplasmosis; congenital varicella syndrome; cytomegalovirus; hepatitis B; neonatal herpes; parvovirus B19; rubella