title: [A Study of Patients with Regional Lymph Node Recurrence after Breast Surgery].
abstract: Regional lymph node recurrence without distant metastasis after the initial treatment of breast cancer is a relatively rare event. The optimal management for regional lymph node recurrence is poorly understood. We retrospectively evaluated 21 patients who developed regional lymph node recurrence between January 1, 2003 and December 31, 2014. The median interval between regional lymph node recurrence and distant metastasis was 1.0 years(range, 0.4 to 2.5 years). On followup, 15 cases(71.4%)were found to eventually develop distant metastases. Median follow-up time after lymph node recurrence was 1.8 years(range, 0.4 to 20.3 years). The 2-year survival rate after regional lymph node recurrence was 65.5%. The mean distant-disease-free interval was 2.2 years in patients with estrogen receptor(ER)-positive tumor(n=10)and 0.7 years in patients with ER-negative tumor(n=11). The distant-disease-free interval after regional lymph node recurrence was significantly shorter in patients with ER-negative tumor than in patients with ER-positive tumor(p=0.008). The 2-year survival rate after regional lymph node recurrence was significantly lower in patients with ER-negative tumor(33.3%)than in patients with ER-positive tumor(100%, p=0.016). This study revealed that regional lymph node recurrence after initial treatment is associated with an increased risk of distant metastasis and death and ER-negative tumors are indicative of a poor prognosis.
authors.affiliation: Dept. of Surgery, Toyama City Hospital.
authors.forename: Wataru
authors.initials: W
authors.lastname: Fukushima
authors.forename: Shogo
authors.initials: S
authors.lastname: Maruzen
authors.forename: Yasumichi
authors.initials: Y
authors.lastname: Yagi
authors.forename: Shozo
authors.initials: S
authors.lastname: Sasaki
authors.forename: Itsuro
authors.initials: I
authors.lastname: Terada
authors.forename: Akemi
authors.initials: A
authors.lastname: Yoshikawa
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Kitagawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Fujimura
authors.forename: Ryohei
authors.initials: R
authors.lastname: Izumi
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Saito
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000737:chemistry / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008207:Lymphatic Metastasis; D008408:Mastectomy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000737:chemistry / Q000175:diagnosis* / Q000401:mortality; D011960:Receptors, Estrogen / Q000032:analysis; D012189:Retrospective Studies
chemical_list: D011960:Receptors, Estrogen