title: Blood ghrelin, adiponectin and resistin levels during controlled ovarian stimulation in IVF cycles.
abstract: The aim of the present study was to investigate changes of blood ghrelin, adiponectin and resistin levels in IVF/ICSI-ET cycles. Twenty women were stimulated with recombinant FSH in a GnRH agonist short protocol for IVF/ICSI. Blood samples were taken on cycle day 2 before the commencement of injections, on cycle day 6 and on the days of HCG injection, oocyte pick up (OPU), embryo transfer (ET) as well as 7 and 12 days post-ET. Serum E2 levels increased during the stimulation, peaking on the HCG day and declined thereafter (p<0.001). Serum progesterone levels started to increase on the OPU day, peaking on the ET day (p<0.001) and decreased on days 7 and 12 post-ET. Plasma ghrelin remained unchanged during the whole cycle. Serum adiponectin levels remained stable during the stimulation period until the ET day and decreased on days 7 and 12 post-ET (p<0.001). Serum resistin levels increased until the ET day (p<0.05), remained unchanged on day 7 post-ET and decreased on day 12 post-ET (p<0.05). The present study shows for the first time that ghrelin levels did not change significantly during IVF/ICSI-ET cycles. Resistin levels increased during the stimulation period while adiponectin levels remained stable decreasing during the luteal phase.
authors.affiliation: Department of Obstetrics and Gynecology, University of Thessaly, Larissa, Greece. kdafop@med.uth.gr.
authors.forename: K
authors.initials: K
authors.lastname: Dafopoulos
authors.forename: C I
authors.initials: CI
authors.lastname: Messini
authors.forename: G
authors.initials: G
authors.lastname: Anifandis
authors.forename: P
authors.initials: P
authors.lastname: Georgoulias
authors.forename: D
authors.initials: D
authors.lastname: Sourlas
authors.forename: I E
authors.initials: IE
authors.lastname: Messinis
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D005260:Female; D005307:Fertilization in Vitro; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D010062:Ovulation Induction; D052243:Resistin / Q000097:blood*
chemical_list: D052242:Adiponectin; D054439:Ghrelin; D052243:Resistin