title: G protein pathway suppressor 2 (GPS2) acts as a tumor suppressor in liposarcoma.
abstract: Liposarcoma(LPS) is the most common type of soft tissue sarcoma accounting for 20 % of all adult sarcomas. However, the molecular pathogenesis of this malignancy is still poorly understood. Here, we showed that GPS2 expression was downregulated in LPS and correlated with the prognosis of this disease. In vitro study showed that knockdown of GPS2 resulted in enhanced proliferation and migration of LPS cell line SW872, without significant influence of cell death. Conclusively, our results suggest that GPS2 may act as a tumor suppressor in LPS and serve as a potential prognosis marker for this disease.
authors.affiliation: Department of General Surgery, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Huang
authors.affiliation: Department of Experimental Hematology, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing, 100850, China.
authors.forename: Feng-Jun
authors.initials: FJ
authors.lastname: Xiao
authors.affiliation: Department of Experimental Hematology, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing, 100850, China.
authors.forename: Shao-Xia
authors.initials: SX
authors.lastname: Wang
authors.affiliation: Department of Experimental Hematology, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing, 100850, China.
authors.forename: Rong-Hua
authors.initials: RH
authors.lastname: Yin
authors.affiliation: Department of General Surgery, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
authors.forename: Can-Rong
authors.initials: CR
authors.lastname: Lu
authors.affiliation: Department of General Surgery, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
authors.forename: Qing-Fang
authors.initials: QF
authors.lastname: Li
authors.affiliation: Department of General Surgery, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
authors.forename: Na
authors.initials: N
authors.lastname: Liu
authors.affiliation: Department of General Surgery, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Experimental Hematology, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing, 100850, China. wangls@bmi.ac.cn.
authors.forename: Li-Sheng
authors.initials: LS
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China. lipeiyu6301@163.com.
authors.forename: Pei-Yu
authors.initials: PY
authors.lastname: Li
mesh_terms: D050156:Adipogenesis; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017209:Apoptosis / Q000235:genetics; D015415:Biomarkers; D002453:Cell Cycle / Q000235:genetics; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation; D005260:Female; D005500:Follow-Up Studies; D015870:Gene Expression; D055785:Gene Knockdown Techniques; D006801:Humans; D007150:Immunohistochemistry; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism*; D008080:Liposarcoma / Q000235:genetics / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015398:Signal Transduction; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D015415:Biomarkers; C103316:GPS2 protein, human; D047908:Intracellular Signaling Peptides and Proteins; D025521:Tumor Suppressor Proteins
keywords: DDLPS; GPS2; Liposarcoma; WDLPS