title: Unprotected Amino Acids as Stable Radical Precursors for Heterocycle C-H Functionalization.
abstract: An efficient and general method for the C-H alkylation of heteroarenes using unprotected amino acids as stable alkyl radical precursors is reported. This one-pot procedure is performed open to air under aqueous conditions and is effective for several natural and unnatural amino acids. Heterocycles of varying structure are suitably functionalized, and reactivity trends reflect the nucleophilic character of the radical species generated.
authors.affiliation: Department of Chemistry and Chemical Biology, University of California , 5200 North Lake Road, Merced, California 95343, United States.
authors.forename: Duy N
authors.initials: DN
authors.lastname: Mai
authors.affiliation: Department of Chemistry and Chemical Biology, University of California , 5200 North Lake Road, Merced, California 95343, United States.
authors.forename: Ryan D
authors.initials: RD
authors.lastname: Baxter