title: OK-432 (Sapylin) Reduces Seroma Formation After Axillary Lymphadenectomy in Breast Cancer.
abstract: Purpose/aim: Modified radical mastectomy is the standard surgery for breast cancer in developing countries. However, seroma formation regarded as the most frequent postoperative complication limits the therapeutic benefit of mastectomy and axillary surgery. The purpose of this study was to evaluate the efficacy of OK-432 in reducing seroma formation after axillary dissection.
  
  
  METHODS
  This prospective cohort study included 80 patients with advanced breast cancer who underwent modified radical mastectomy. Patients were randomized into two groups, which differed with the OK-432 administration. N = 40 patients per group were treated with either OK-432 plus closed suction drainage or drainage-only.
  
  
  RESULTS
  In comparison with the drainage-only group, we found that patients in the OK-432 group had a lower drainage volume (p = .030) and a shorter duration of axillary drainage (p < .01). Besides, the use of OK-432 could reduce the incidence of seroma formation (p < .01) and the volume of seroma (p = .040). There were also significant differences in reducing the chance of evacuative punctures (p = .036) and the healing time (p < .01) between control and OK-432 group.
  
  
  CONCLUSIONS
  OK-432 not only shortened the suction drainage duration, but also significantly reduced seroma formation as well as the needs for aspiration punctures after modified radical mastectomy.
authors.affiliation: a Department of Thyroid and Breast Surgery, Tongji Hospital of Tongji Medical College , Huazhong University of Science and Technology , Wuhan , P. R. China.
authors.forename: Deguang
authors.initials: D
authors.lastname: Kong
authors.affiliation: b Department of Geriatrics, Tongji Hospital of Tongji Medical College , Huazhong University of Science and Technology , Wuhan , P. R. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.affiliation: a Department of Thyroid and Breast Surgery, Tongji Hospital of Tongji Medical College , Huazhong University of Science and Technology , Wuhan , P. R. China.
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Li
authors.affiliation: a Department of Thyroid and Breast Surgery, Tongji Hospital of Tongji Medical College , Huazhong University of Science and Technology , Wuhan , P. R. China.
authors.forename: Qiuxia
authors.initials: Q
authors.lastname: Cui
authors.affiliation: a Department of Thyroid and Breast Surgery, Tongji Hospital of Tongji Medical College , Huazhong University of Science and Technology , Wuhan , P. R. China.
authors.forename: Kun
authors.initials: K
authors.lastname: Wang
authors.affiliation: c Department of Oncology, Tongji Hospital of Tongji Medical College , Huazhong University of Science and Technology , P. R. China.
authors.forename: Kongming
authors.initials: K
authors.lastname: Wu
authors.affiliation: a Department of Thyroid and Breast Surgery, Tongji Hospital of Tongji Medical College , Huazhong University of Science and Technology , Wuhan , P. R. China.
authors.forename: Gaosong
authors.initials: G
authors.lastname: Wu
mesh_terms: D000328:Adult; D001365:Axilla; D001688:Biological Products / Q000008:administration & dosage / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000601:surgery*; D005260:Female; D006801:Humans; D015994:Incidence; D008197:Lymph Node Excision / Q000009:adverse effects*; D008198:Lymph Nodes / Q000601:surgery*; D015411:Mastectomy, Modified Radical / Q000009:adverse effects*; D008875:Middle Aged; D010844:Picibanil / Q000008:administration & dosage / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000453:epidemiology / Q000517:prevention & control*; D011446:Prospective Studies; D049291:Seroma / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D013396:Suction; D013997:Time Factors
chemical_list: D001688:Biological Products; C569879:streptococcal preparation 722; D010844:Picibanil
keywords: OK-432; Sapylin; breast cancer; modified radical mastectomy; postoperative complication; seroma formation