title: Relevance of 3D Cholangiography and Transient Elastography to Assess Cystic Fibrosis-Associated Liver Disease?
abstract: Background. Cystic fibrosis-associated liver disease (CFLD) is a major cause of death. The objective of our retrospective study was to describe the relevance of magnetic resonance imaging (MRI) and liver stiffness measurement (LSM) for CFLD evaluation. Methods. All cystic fibrosis adult patients evaluated by MRI and LSM were included. MR signs of portal hypertension (PHT), dysmorphia, or cholangitis were collected and LSM expressed in kPa and Metavir. Results. Of 25 patients, 52% had abnormal MRI. Median LSM was 5.7 kPa (3.4-9.9). Three patients had F2 score and one had F3 score. In patients with PHT, LSM was 7.85 kPa (3.7-9.9) compared to 5 (3.4-7.5) in others, p = 0.02. In patients with abnormal liver function tests, 50% had increased LSM (≥F2), whereas 94% with normal tests had normal LSM (p = 0.04). Seven patients had abnormal MRI despite normal ultrasonography. Conclusions. MRI and LSM provide useful information on CFLD and may help to screen patients with PHT.
authors.affiliation: Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France.
authors.forename: C
authors.initials: C
authors.lastname: Lemaitre
authors.affiliation: Department of Pneumology, Adult Cystic Fibrosis Centre, Rouen University Hospital, Rouen, France.
authors.forename: S
authors.initials: S
authors.lastname: Dominique
authors.affiliation: Department of Gastroenterology, Le Havre General Hospital, Le Havre, France.
authors.forename: E
authors.initials: E
authors.lastname: Billoud
authors.affiliation: Department of Radiology, Rouen University Hospital, Rouen, France.
authors.forename: M
authors.initials: M
authors.lastname: Eliezer
authors.affiliation: Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France.
authors.forename: H
authors.initials: H
authors.lastname: Montialoux
authors.affiliation: Clinical Biology Institute, Rouen University Hospital, Rouen, France.
authors.forename: M
authors.initials: M
authors.lastname: Quillard
authors.affiliation: Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France.
authors.forename: G
authors.initials: G
authors.lastname: Riachi
authors.affiliation: Department of Radiology, Rouen University Hospital, Rouen, France.
authors.forename: E
authors.initials: E
authors.lastname: Koning
authors.affiliation: Department of Pneumology, Adult Cystic Fibrosis Centre, Rouen University Hospital, Rouen, France.
authors.forename: H
authors.initials: H
authors.lastname: Morisse-Pradier
authors.affiliation: Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France; INSERM U1073, Institute for Research and Innovation in Biomedicine, Faculty of Medicine, University of Rouen, Rouen, France.
authors.forename: G
authors.initials: G
authors.lastname: Savoye
authors.affiliation: Department of Radiology, Rouen University Hospital, Rouen, France.
authors.forename: C
authors.initials: C
authors.lastname: Savoye-Collet
authors.affiliation: Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, France.
authors.forename: O
authors.initials: O
authors.lastname: Goria
mesh_terms: D000293:Adolescent; D000328:Adult; D002758:Cholangiography; D003550:Cystic Fibrosis / Q000150:complications*; D054459:Elasticity Imaging Techniques; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008107:Liver Diseases / Q000000981:diagnostic imaging* / Q000209:etiology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult