title: Natural products from Cuscuta reflexa Roxb. with antiproliferation activities in HCT116 colorectal cell lines.
abstract: Parasitic Cuscuta reflexa Roxb. possesses many medicinal properties and is a rich source of a variety of biologically relevant natural products. Natural products are the prime source of leads, drugs, and drug templates, and many of the anticancer and antiviral drugs are either based on natural product or derived from them. Cancer is a devastating disease and one of the leading causes of death worldwide despite improvements in patient survival during the past 50 years; new and improved treatments for cancer are therefore actively sought. Colorectal cancer is the fourth most prevalent cancer worldwide and is responsible for nearly 9% of all cancer deaths. Our search for anticancer natural products from C. reflexa has yielded four natural products: Scoparone (1), p-coumaric acid (2), stigmasta-3,5-diene (3) and 1-O-p-hydroxycinnamoylglucose (4) and among them 1-O-p-hydroxycinnamoyldlucose (4) showed promising antiproliferative activities in HCT116 colorectal cell lines, whereas compounds 1-3 showed moderate activities.
authors.affiliation: a Department of Chemistry , University of AJK , Muzaffarabad , Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Riaz
authors.affiliation: b Department of Biology , Lahore University of Management Sciences , Lahore , Pakistan.
authors.forename: Aishah
authors.initials: A
authors.lastname: Bilal
authors.affiliation: c International Center for Chemical and Biological Sciences , University of Karachi , Karachi , Pakistan.
authors.forename: Muhammad Shaiq
authors.initials: MS
authors.lastname: Ali
authors.affiliation: c International Center for Chemical and Biological Sciences , University of Karachi , Karachi , Pakistan.
authors.forename: Itrat
authors.initials: I
authors.lastname: Fatima
authors.affiliation: b Department of Biology , Lahore University of Management Sciences , Lahore , Pakistan.
authors.forename: Amir
authors.initials: A
authors.lastname: Faisal
authors.affiliation: d Department of Pharmacy , Abbottabad University of Science and Technology , Abbottabad , Pakistan.
authors.forename: Muhammad Azhar
authors.initials: MA
authors.lastname: Sherkheli
authors.affiliation: a Department of Chemistry , University of AJK , Muzaffarabad , Pakistan.
authors.forename: Adnan
authors.initials: A
authors.lastname: Asghar
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D001688:Biological Products / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D034182:Cuscuta / Q000737:chemistry*; D045325:HCT116 Cells; D006801:Humans
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001688:Biological Products
keywords: Cuscuta reflexa; HCT116; colorectal cancer cell line; natural products