title: Validity of the Portuguese CHO-KLAT in Brazil.
abstract: BACKGROUND
  It is essential to assess the health-related quality of life outcomes of boys with haemophilia in Brazil. The Canadian Haemophilia Outcomes-Kids Life Assessment Tool (CHO-KLAT) was recently adapted for this population.
  
  
  OBJECTIVE
  To test the construct validity of the Portuguese version of the CHO-KLAT.
  
  
  METHODS
  We recruited 50 boys, with moderate [factor VIII (FVIII) level 1-5%] or severe (FVIII level <1%) haemophilia, to participate in a descriptive study to establish a baseline understanding of the current status of boys with haemophilia in Brazil. All boys were required to complete the Brazilian CHO-KLAT and Brazilian Pediatric Quality of Life Inventory (PedsQL) by self-report. We examined the correlation between the CHO-KLAT and PedsQL scores to establish the construct validity of the Brazilian version of the CHO-KLAT.
  
  
  RESULTS
  We obtained CHO-KLAT and PedsQL data from 35 boys with severe haemophilia and 15 with moderate haemophilia. They ranged in age from 7.3 to 18.0 years, with a mean of 13.0 years. They reported a mean CHO-KLAT score of 72.3 (range = 44.1-93.9). The mean PedsQL score was 79.9 (range = 45.7-96.7), with physical health (mean of 83.9) being better than psychosocial health (77.8). The Pearson's correlation between CHO-KLAT and PedsQL was 0.47 respectively (P < 0.001). The CHO-KLAT had a moderate and inverse relationship with the degree to which they were bothered by their haemophilia (ρ = -0.53), while the PedsQL had a weaker relationship (ρ = -0.27).
  
  
  CONCLUSIONS
  The results confirm the validity of the Portuguese version of the CHO-KLAT. This measure is now available for clinical trials in boys with haemophilia in Brazil.
authors.affiliation: Service of Hematology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
authors.forename: P R
authors.initials: PR
authors.lastname: Villaça
authors.affiliation: Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada.
authors.forename: V S
authors.initials: VS
authors.lastname: Blanchette
authors.affiliation: Centro de Hemofilia e Instituto da Criança, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
authors.forename: J D A
authors.initials: JD
authors.lastname: Carneiro
authors.affiliation: Unit of Hemophilia IHTC, Cláudio L.P. Correa, Hemocentro Unicamp, INCT do Sangue, University of Campinas, Campinas, Brazil.
authors.forename: M C
authors.initials: MC
authors.lastname: Ozelo
authors.affiliation: Department of Hematology, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
authors.forename: S
authors.initials: S
authors.lastname: Antunes
authors.affiliation: Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada.
authors.forename: B M
authors.initials: BM
authors.lastname: Feldman
authors.affiliation: Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Abad
authors.affiliation: Evaluating Children's Health Outcomes Research Centre, Laurentian University, Sudbury, ON, Canada.
authors.forename: K
authors.initials: K
authors.lastname: Usuba
authors.affiliation: School of Rural and Northern Health, Laurentian University, Sudbury, ON, Canada.
authors.forename: N L
authors.initials: NL
authors.lastname: Young
mesh_terms: D000293:Adolescent; D001938:Brazil; D002648:Child; D006467:Hemophilia A / Q000188:drug therapy*; D006801:Humans; D008297:Male; D017063:Outcome Assessment, Health Care / Q000379:methods*; D011788:Quality of Life
keywords: haemophilia; outcome measurement; paediatrics; quality of life