title: Decreased adult neurogenesis in hibernating Syrian hamster.
abstract: Generation of new neurons from adult neural stem cells occurs in the dentate gyrus (DG) of the hippocampus and the lateral walls of the lateral ventricles. In this article, we study the neurogenesis that takes place during the hibernation of the Syrian hamster (Mesocricetus auratus). Using a variety of standard neurogenesis markers and 5-bromo-2-deoxyuridine (BrdU) incorporation, we describe a preferential decrease in the proliferation of newborn neurons in the subventricular zone (SVZ) of the hibernating hamsters (torpor) rather than in the hippocampus. Furthermore, we demonstrate that the proliferative capacity is recovered after 3-4days of torpor when arousal is triggered under natural conditions (i.e., not artificially provoked). In addition, we show that tau3R, a tau isoform with three microtubule-binding domains, is a suitable marker to study neurogenesis both in the SVZ and subgranular zone (SGZ) of the Syrian hamster brain.
authors.affiliation: Instituto Cajal, CSIC, Madrid, Spain; Laboratorio Cajal de Circuitos Corticales (CTB), Universidad Politécnica de Madrid, Madrid, Spain; Facultad de Farmacia, Universidad San Pablo CEU, Madrid, Spain. Electronic address: gleon@cajal.csic.es.
authors.forename: Gonzalo
authors.initials: G
authors.lastname: León-Espinosa
authors.affiliation: CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Spain; Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM), Campus Cantoblanco UAM, Madrid, Spain.
authors.forename: Esther
authors.initials: E
authors.lastname: García
authors.affiliation: Hospital Clínico San Carlos, Madrid, Spain.
authors.forename: Ulises
authors.initials: U
authors.lastname: Gómez-Pinedo
authors.affiliation: CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Spain; Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM), Campus Cantoblanco UAM, Madrid, Spain.
authors.forename: Félix
authors.initials: F
authors.lastname: Hernández
authors.affiliation: Instituto Cajal, CSIC, Madrid, Spain; Laboratorio Cajal de Circuitos Corticales (CTB), Universidad Politécnica de Madrid, Madrid, Spain; CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: DeFelipe
authors.affiliation: CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Spain; Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM), Campus Cantoblanco UAM, Madrid, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Ávila
mesh_terms: D000818:Animals; D001143:Arousal / Q000502:physiology; D001921:Brain / Q000166:cytology / Q000502:physiology*; D001973:Bromodeoxyuridine; D002452:Cell Count; D049109:Cell Proliferation / Q000502:physiology; D006605:Hibernation / Q000502:physiology*; D007150:Immunohistochemistry; D008297:Male; D008647:Mesocricetus; D039842:Neural Cell Adhesion Molecule L1 / Q000378:metabolism; D055495:Neurogenesis / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D012794:Sialic Acids / Q000378:metabolism; D055153:Stem Cell Niche / Q000502:physiology; D016875:tau Proteins / Q000378:metabolism
chemical_list: D039842:Neural Cell Adhesion Molecule L1; D012794:Sialic Acids; C103469:polysialyl neural cell adhesion molecule; D016875:tau Proteins; D001973:Bromodeoxyuridine
keywords: Syrian hamster; hibernation; neurogenesis