title: Model systems for the study of steroid-induced IOP elevation.
abstract: Steroid-induced IOP elevation affects a significant number of patients. It results from a decrease in outflow facility of the aqueous humor. To understand the pathophysiology of this condition a number of model systems have been created. These include ex-vivo cell and organ cultures as well as in-vivo animal models in organisms ranging from rodents to primates. These model systems can be used to investigate specific aspects of steroid-induced IOP elevation. This brief review summarizes the strengths and limitations of the various model systems and provides examples of where these systems have been successfully used to advance our understanding of steroid-induced IOP elevation.
authors.affiliation: Department of Cell Biology, SUNY Downstate, NY, USA.
authors.forename: Ilya
authors.initials: I
authors.lastname: Rybkin
authors.affiliation: Departamento de Oftalmologia, Facultad de Medicina, Universidad Nacional del Nordeste, Corrientes, Argentina; Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors.forename: Rosana
authors.initials: R
authors.lastname: Gerometta
authors.affiliation: Department of Cell Biology, SUNY Downstate, NY, USA.
authors.forename: Gabrielle
authors.initials: G
authors.lastname: Fridman
authors.affiliation: Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors.forename: Oscar
authors.initials: O
authors.lastname: Candia
authors.affiliation: Department of Cell Biology, SUNY Downstate, NY, USA; Department of Ophthalmology, SUNY Downstate, NY, USA. Electronic address: john.danias@downstate.edu.
authors.forename: John
authors.initials: J
authors.lastname: Danias
mesh_terms: D000818:Animals; D018929:Cell Culture Techniques; D003907:Dexamethasone / Q000009:adverse effects; D004195:Disease Models, Animal; D005901:Glaucoma / Q000139:chemically induced / Q000503:physiopathology; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D009798:Ocular Hypertension / Q000139:chemically induced* / Q000503:physiopathology; D009924:Organ Culture Techniques; D014129:Trabecular Meshwork / Q000187:drug effects* / Q000473:pathology; D014222:Triamcinolone Acetonide / Q000009:adverse effects
chemical_list: D005938:Glucocorticoids; D003907:Dexamethasone; D014222:Triamcinolone Acetonide
keywords: Glaucoma; Intraocular pressure; Model; Steroids