title: Synthesis and evaluation of multi-wall carbon nanotube-paclitaxel complex as an anti-cancer agent.
abstract: OBJECTIVE
  The aim of this study was to design multi-walled carbon nanotubes (MWCNTs) loaded with paclitaxel (PTX) anti-cancer drug and investigate its anti-cancerous efficacy of human gastric cancer.
  
  
  BACKGROUND
  Carbon nanotubes (CNTs) represent a novel nano-materials applied in various fields such as drug delivery due to their unique chemical properties and high drug loading.
  
  
  METHODS
  In this study, multi-walled carbon nanotubes (MWCNTs) pre-functionalized covalently with a paclitaxel (PTX) as an anti-cancer drug and evaluated by different analyses including, scanning electron microscope (SEM), particle size analyzer and cellular analyses.
  
  
  RESULTS
  A well conjugated of anti-cancer drug on the carbon nanotube surfaces was shown. This study demonstrates that the MWCN-PTX complex is a potentially useful system for delivery of anti-cancer drugs. The flow cytometry, CFU and MTT assay results have disclosed that MWCNT/PTXs might promote apoptosis in MKN-45 gastric adenocarcinoma cell line.
  
  
  CONCLUSIONS
  According to results, our simple method can be designed a candidate material for chemotherapy. It has presented a few bio-related applications including, their successful use as a nano-carriers for drug transport.
authors.affiliation: Enzyme Technology Lab, Genetics & Metabolism Research Group, Pasteur Institute of Iran, Tehran, Iran.
authors.forename: Fariba
authors.initials: F
authors.lastname: Ghasemvand
authors.affiliation: Department of Biomaterials Engineering, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran.
authors.forename: Esmaeil
authors.initials: E
authors.lastname: Biazar
authors.affiliation: Department of Chemistry, Science and Research Branch, Islamic Azad University, Yazd, Iran.
authors.forename: Sara
authors.initials: S
authors.lastname: Tavakolifard
authors.affiliation: Department of Biomaterials Engineering, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Khaledian
authors.affiliation: Enzyme Technology Lab, Genetics & Metabolism Research Group, Pasteur Institute of Iran, Tehran, Iran.
authors.forename: Saeid
authors.initials: S
authors.lastname: Rahmanzadeh
authors.affiliation: Brain and Spinal Injury Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Daruosh
authors.initials: D
authors.lastname: Momenzadeh
authors.affiliation: Department of Biomaterials Engineering, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran.
authors.forename: Roshanak
authors.initials: R
authors.lastname: Afroosheh
authors.affiliation: Department of Biomaterials Engineering, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran.
authors.forename: Faezeh
authors.initials: F
authors.lastname: Zarkalami
authors.affiliation: Department of Biomaterials Engineering, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran.
authors.forename: Marjan
authors.initials: M
authors.lastname: Shabannezhad
authors.affiliation: Department of Biology, Garmsar Branch, Islamic Azad University, Garmsar, Iran.
authors.forename: Saeed
authors.initials: S
authors.lastname: Hesami Tackallou
authors.affiliation: Department of Anesthesiology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Nilofar
authors.initials: N
authors.lastname: Massoudi
authors.affiliation: Proteomics Research center, Shahid Beheshti University of medical sciences, Tehran, Iran; Stem cell preparation unit, Eye Research center, Farabi Eye Hospital, Tehran University of medical sciences, Tehran, Iran.
authors.forename: Saeed
authors.initials: S
authors.lastname: Heidari Keshel
keywords: Gastric cancer; MKN-45 cell line; Multi-walled carbon nanotubes; Paclitaxel; Structural investigations