title: Evaluation of the Relation between Vitamin D and Serum Omentin and Vaspin Levels in Women.
abstract: BACKGROUND
  Vitamin D deficiency is a common health problem seen worldwide. Adipokines released from adipose tissue play important roles in the control of appetite and satiety, modulation of body fat distribution, regulation of insulin sensitivity and secretion, control of blood pressure, and regulation of endothelial functions and inflammation. The aim of the present study is to investigate how vitamin D levels affect serum vaspin and omentin levels.
  
  
  METHODS
  This is a cross-sectional study design. A total of 77 female volunteers were included in the study, and they were divided into 3 groups according to vitamin D levels. Relation of vitamin D with serum vaspin and omentin levels was determined in these groups.
  
  
  RESULTS
  Serum omentin, vaspin and parathyroid hormone (PTH) levels differed significantly between the groups (p<0.001, p<0.001, p=0.001, respectively). Omentin levels correlated significantly and negatively with the vitamin D and vaspin levels, but there was a significant positive correlation between omentin and PTH (r=-0.626, p<0.001; r=-0.867, p<0.001; r=0.461, P<0.001, respectively). A significant positive correlation was detected between vaspin levels and vitamin D, whereas omentin and PTH levels correlated negatively and significantly (r=0.374, p<0.001; r=-0.867, p<0.001; r=-0.374, p=0.002, respectively).
  
  
  CONCLUSIONS
  Vitamin D may affect the release of adipokines from the adipose tissue, and this effect may be in a negative or positive manner. This effect of vitamin D may probably be mediated via vitamin D receptors exhibited in the adipose tissue, or via mechanisms not identified yet. The results of this study suggested that there was a significant, positive correlation between serum vitamin D levels and vaspin, whereas a significant, negative correlation between vitamin D levels and omentin. Further studies on larger series are needed in order to confirm these results.
authors.affiliation: Internal Medicine Clinic, Bezmialem Vakif University, Faculty of Medicine, Fatih, Istanbul, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Zorlu
authors.affiliation: Internal Medicine Clinic, Bezmialem Vakif University, Faculty of Medicine, Fatih, Istanbul, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Kiskac
authors.affiliation: Internal Medicine Clinic, Bezmialem Vakif University, Faculty of Medicine, Fatih, Istanbul, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Cakirca
authors.affiliation: Internal Medicine Clinic, Bezmialem Vakif University, Faculty of Medicine, Fatih, Istanbul, Turkey.
authors.forename: C
authors.initials: C
authors.lastname: Karatoprak
authors.affiliation: Deparment of Medical Biochemistry, Bezmialem Vakif University, Faculty of Medicine, Fatih, Istanbul, Turkey.
authors.forename: E M
authors.initials: EM
authors.lastname: Güler
authors.affiliation: Internal Medicine Clinic, Bezmialem Vakif University, Faculty of Medicine, Fatih, Istanbul, Turkey.
authors.forename: K
authors.initials: K
authors.lastname: Çelik
authors.affiliation: Internal Medicine Clinic, Bezmialem Vakif University, Faculty of Medicine, Fatih, Istanbul, Turkey.
authors.forename: I
authors.initials: I
authors.lastname: Gültepe
authors.affiliation: Internal Medicine Clinic, Bezmialem Vakif University, Faculty of Medicine, Fatih, Istanbul, Turkey.
authors.forename: M A
authors.initials: MA
authors.lastname: Cikrikcioglu
authors.affiliation: Deparment of Medical Biochemistry, Bezmialem Vakif University, Faculty of Medicine, Fatih, Istanbul, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Kocyigit
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood*; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D006801:Humans; D037102:Lectins / Q000097:blood*; D008875:Middle Aged; D015843:Serpins / Q000097:blood*; D014807:Vitamin D / Q000097:blood*
chemical_list: D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins; C507339:SERPINA12 protein, human; D015843:Serpins; D014807:Vitamin D