title: Evaluation of microvessel density and p53 expression in pancreatic adenocarcinoma.
abstract: OBJECTIVE
  To evaluate the prognostic significance of microvessel density and p53 expression in pancreatic cancer.
  
  
  METHODS
  Between 2008 and 2012, 49 patients with pancreatic adenocarcinoma underwent resection with curative intention. The resected specimens were immunohistochemically stained with anti-p53 and anti-CD34 antibodies. Microvessel density was assessed by counting vessels within ten areas of each tumoral section a highpower microscope.
  
  
  RESULTS
  The microvessel density ranged from 21.2 to 54.2 vessels/mm2. Positive nuclear staining for p53 was found in 20 patients (40.6%). The overall median survival rate after resection was 24.1 months and there were no differences in survival rates related to microvessel density or p53 positivity. Microvessel density was associated with tumor diameter greater than 3.0 cm and with R0 resection failure.
  
  
  CONCLUSIONS
  Microvessel density was associated with R1 resection and with larger tumors. p53 expression was not correlated with intratumoral microvessel density in pancreatic adenocarcinoma.
authors.affiliation: Faculdade de Medicina da Universidade de São Paulo, Departamento de Gastroenterologia.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Jureidini
authors.affiliation: Faculdade de Medicina da Universidade de São Paulo, Departamento de Gastroenterologia.
authors.forename: José Eduardo Monteiro
authors.initials: JE
authors.lastname: da Cunha
authors.affiliation: Faculdade de Medicina da Universidade de São Paulo, Departamento de Gastroenterologia.
authors.forename: Flavio
authors.initials: F
authors.lastname: Takeda
authors.affiliation: Faculdade de Medicina da Universidade de São Paulo, Departamento de Gastroenterologia.
authors.forename: Guilherme Naccache
authors.initials: GN
authors.lastname: Namur
authors.affiliation: Faculdade de Medicina da Universidade de São Paulo, Departamento de Gastroenterologia.
authors.forename: Thiago Costa
authors.initials: TC
authors.lastname: Ribeiro
authors.affiliation: Departamento de Patologia, São Paulo/SP, Brazil.
authors.forename: Rosely
authors.initials: R
authors.lastname: Patzina
authors.affiliation: Faculdade de Medicina da Universidade de São Paulo, Departamento de Gastroenterologia.
authors.forename: Estela Rr
authors.initials: ER
authors.lastname: Figueira
authors.affiliation: Faculdade de Medicina da Universidade de São Paulo, Departamento de Gastroenterologia.
authors.forename: Ulysses
authors.initials: U
authors.lastname: Ribeiro
authors.affiliation: Faculdade de Medicina da Universidade de São Paulo, Departamento de Gastroenterologia.
authors.forename: Telesforo
authors.initials: T
authors.lastname: Bacchella
authors.affiliation: Faculdade de Medicina da Universidade de São Paulo, Departamento de Gastroenterologia.
authors.forename: Ivan
authors.initials: I
authors.lastname: Cecconello
mesh_terms: D021441:Carcinoma, Pancreatic Ductal / Q000098:blood supply / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D000072662:Margins of Excision; D055806:Microvessels / Q000473:pathology*; D008875:Middle Aged; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000098:blood supply / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D011379:Prognosis; D015996:Survival Rate; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D016159:Tumor Suppressor Protein p53