title: An outbreak of multidrug-resistant tuberculosis among a family.
abstract: Tuberculosis is a major public health problem and it may be complicated by multidrug-resistant tuberculosis (MDR-TB). Wide transmission among immunocompetent contacts of the index case is possible. If you detect tuberculosis in two contacts of the index case, it is called an outbreak. The aim of our paper is to evaluate the characteristics of a MDR-TB outbreak affecting 7 people in a family treated during 2012-2014 in Istanbul Yedikule Training and Research Hospital for Chest Disease and Thoracic Surgery, Turkey. The cultures, spoligotyping, and DNA fingerprinting revealed the same Mycobacterium tuberculosis species as T1 genotype and ST53 subtype. All patients were negative for human immunodeficiency virus and free of other underlying diseases.
authors.affiliation: Yedikule Training and Research Hospital for Chest Disease and Thoracic Surgery, Department of Pulmonary Medicine, Zeytinburnu, Istanbul, Turkey. Electronic address: snmkaraosman@gmail.com.
authors.forename: Sinem
authors.initials: S
authors.lastname: Iliaz
authors.affiliation: Yedikule Training and Research Hospital for Chest Disease and Thoracic Surgery, Department of Pulmonary Medicine, Zeytinburnu, Istanbul, Turkey.
authors.forename: Emel
authors.initials: E
authors.lastname: Caglar
authors.affiliation: Istanbul University, Institute for Medical Experimental Research, Molecular Tuberculosis Epidemiology Laboratory, Fatih, Istanbul, Turkey.
authors.forename: Orhan Kaya
authors.initials: OK
authors.lastname: Koksalan
authors.affiliation: Yedikule Training and Research Hospital for Chest Disease and Thoracic Surgery, Department of Pulmonary Medicine, Zeytinburnu, Istanbul, Turkey.
authors.forename: Efsun Gonca Ugur
authors.initials: EG
authors.lastname: Chousein
mesh_terms: D000293:Adolescent; D005190:Family; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D009169:Mycobacterium tuberculosis / Q000235:genetics; D018088:Tuberculosis, Multidrug-Resistant / Q000175:diagnosis / Q000635:transmission*; D014421:Turkey; D055815:Young Adult
keywords: Contact; Multidrug resistance; Transmission; Tuberculosis