title: Emotion regulation and amygdala-precuneus connectivity: Focusing on attentional deployment.
abstract: Attentional deployment is an emotion regulation strategy that involves shifting attentional focus. Deploying attention to non-arousing, compared to arousing, regions of unpleasant images has been associated with reduced negative affect, reduced amygdala activation, and increased activity in fronto-parietal control networks. The current study examined neural correlates and functional connectivity associated with using attentional deployment to increase negative affect (deploying attention towards arousing unpleasant information) or to decrease negative affect (deploying attention away from arousing unpleasant information), compared to naturally viewing unpleasant images, in 42 individuals while concurrently monitoring eye movements. Directing attention to both arousing and non-arousing regions resulted in enhanced fronto-parietal activation compared to natural viewing, but only directing attention to non-arousing regions was associated with changes in amygdala activation. There were no significant differences in connectivity between naturally viewing unpleasant images and focusing on arousing regions. However, naturally viewing unpleasant images, relative to focusing on non-arousing regions, was associated with increased connectivity between the amygdala and visual cortex, while focusing on non-arousing regions of unpleasant images, compared to natural viewing, was associated with increased connectivity between the amygdala and the precuneus. Amygdala-precuneus connectivity correlated positively with eye-tracking measures of attentional deployment success and with trait reappraisal. Deploying attention away from arousing unpleasant information, then, may depend upon functional relationships between the amygdala and parietal regions implicated in attentional control. Furthermore, these relationships might relate to the ability to successfully implement attentional deployment, and the predisposition to utilize adaptive emotion regulation strategies.
authors.affiliation: Department of Psychiatry, University of California, San Francisco, CA, 94143, USA. jamie.ferri@ucsf.edu.
authors.forename: Jamie
authors.initials: J
authors.lastname: Ferri
authors.affiliation: Stony Brook University, Stony Brook, NY, 11794-2500, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Schmidt
authors.affiliation: Stony Brook University, Stony Brook, NY, 11794-2500, USA.
authors.forename: Greg
authors.initials: G
authors.lastname: Hajcak
authors.affiliation: Stony Brook University, Stony Brook, NY, 11794-2500, USA.
authors.forename: Turhan
authors.initials: T
authors.lastname: Canli
mesh_terms: D000679:Amygdala / Q000502:physiology*; D001288:Attention / Q000502:physiology*; D001931:Brain Mapping; D056348:Emotional Intelligence / Q000502:physiology; D004644:Emotions / Q000502:physiology*; D053483:Eye Movement Measurements; D005133:Eye Movements / Q000502:physiology; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D009483:Neuropsychological Tests; D010296:Parietal Lobe / Q000502:physiology*; D010775:Photic Stimulation; D011795:Surveys and Questionnaires; D014796:Visual Perception / Q000502:physiology; D055815:Young Adult
keywords: Attention; Emotion; Functional connectivity