title: Single- and Bayesian Multi-Marker Genome-Wide Association for Haematological Parameters in Pigs.
abstract: Haematological traits are important traits that show associations with immune and metabolic status, as well as diseases in humans and animals. Mapping genome regions that affect the blood cell traits can contribute to the identification of genomic features useable as biomarkers for immune, disease and metabolic status. A genome-wide association study (GWAS) was conducted using PorcineSNP60 BeadChips. Single-marker and Bayesian multi-marker approaches were integrated to identify genomic regions and corresponding genes overlapping for both methods. GWAS was performed for haematological traits of 591 German Landrace pig. Heritability estimates for haematological traits were medium to high. In total 252 single SNPs associated with 12 haematological traits were identified (NegLog10 of p-value > 5). The Bayesian multi-marker approach revealed 102 QTL regions across the genome, indicated by 1-Mb windows with contribution to additive genetic variance above 0.5%. The integration of both methods resulted in 24 overlapping QTL regions. This study identified overlapping QTL regions from single- and multi-marker approaches for haematological traits. Identifying candidate genes that affect blood cell traits provides the first step towards the understanding of the molecular basis of haematological phenotypes.
authors.affiliation: Research Unit 'Functional Genome Analyses', Institute for Genome Biology, Leibniz Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, D-18196, Dummerstorf, Germany.
authors.forename: Siriluck
authors.initials: S
authors.lastname: Ponsuksili
authors.affiliation: Research Unit 'Genomics', Institute for Genome Biology, Leibniz Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, D-18196, Dummerstorf, Germany.
authors.forename: Henry
authors.initials: H
authors.lastname: Reyer
authors.affiliation: Research Unit 'Genomics', Institute for Genome Biology, Leibniz Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, D-18196, Dummerstorf, Germany.
authors.forename: Nares
authors.initials: N
authors.lastname: Trakooljul
authors.affiliation: Research Unit 'Genomics', Institute for Genome Biology, Leibniz Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, D-18196, Dummerstorf, Germany.
authors.forename: Eduard
authors.initials: E
authors.lastname: Murani
authors.affiliation: Research Unit 'Genomics', Institute for Genome Biology, Leibniz Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, D-18196, Dummerstorf, Germany.
authors.forename: Klaus
authors.identifier: http://orcid.org/0000-0002-9523-6790
authors.initials: K
authors.lastname: Wimmers
mesh_terms: D000818:Animals; D001499:Bayes Theorem; D001792:Blood Platelets / Q000378:metabolism; D002874:Chromosome Mapping; D004912:Erythrocytes / Q000378:metabolism; D055106:Genome-Wide Association Study; D006439:Hemodynamics / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci / Q000235:genetics*; D034421:Sus scrofa; D013552:Swine / Q000097:blood / Q000235:genetics*