title: Acute endurance exercise lowers serum fibroblast growth factor 21 levels in Japanese men.
abstract: OBJECTIVE
  The independent effects of acute endurance exercise on FGF21 metabolism are poorly understood. Therefore, the purpose of this study was to determine whether acute endurance exercise modulates serum postprandial FGF21 levels in an age-dependent manner.
  
  
  METHODS
  Exercise intervention trial.
  
  
  METHODS
  Twenty-eight subjects participated in the experiment, of whom 13 were excluded mainly because of a serum FGF21 level below the limit of detection. Thus, data from seven young (age: 18-22 years) and eight elderly male subjects (age: 62-69 years) were analysed.
  
  
  METHODS
  Participants were asked to perform a cycling exercise for 30 min at 70% maximal oxygen uptake, following carbohydrate intake. Blood samples were collected pre-exercise and 0 min, 30 min, 1 h, 3 h and 24 h after the cessation of exercise. Serum FGF21 levels were measured by an enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Higher serum FGF21 was observed in the elderly subjects group throughout the experiment (P < 0·05). There was no significant increase in serum FGF21 levels after the cessation of exercise, whereas serum FGF21 levels were significantly lower 24 h after the exercise compared with those pre-exercise, 0 min, 30 min and 1 h after the cessation of exercise in both groups (P < 0·01). The response did not differ between the two groups because of no significant group × time interaction.
  
  
  CONCLUSIONS
  Acute endurance exercise lowers serum FGF21 levels 24 h following exercise. The results suggest that acute endurance exercise modulates postprandial FGF21 metabolism regardless of age.
authors.affiliation: Faculty of Agriculture, Ryukoku University, Otsu, Japan.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Taniguchi
authors.affiliation: Department of Health Promotion and Exercise, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan.|Research Fellow of Japan Society for the Promotion of Science, Tokyo, Japan.|Faculty of Sport Sciences, Waseda University, Tokorozawa, Japan.|Institute of Advanced Active Aging Research, Tokorozawa, Japan.
authors.forename: Kumpei
authors.initials: K
authors.lastname: Tanisawa
authors.affiliation: Faculty of Sport Sciences, Waseda University, Tokorozawa, Japan.
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Sun
authors.affiliation: Faculty of Sport Sciences, Waseda University, Tokorozawa, Japan.|Institute of Advanced Active Aging Research, Tokorozawa, Japan.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Higuchi
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000368:Aged; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D015444:Exercise; D005346:Fibroblast Growth Factors / Q000097:blood* / Q000378:metabolism; D006801:Humans; D007564:Japan; D008297:Male; D010101:Oxygen Consumption / Q000502:physiology; D019518:Postprandial Period; D013997:Time Factors; D055815:Young Adult
chemical_list: D004040:Dietary Carbohydrates; C414620:fibroblast growth factor 21; D005346:Fibroblast Growth Factors