title: Sustained-release drug delivery of antimicrobials in controlling of supragingival oral biofilms.
abstract: Dental caries, a bacterial biofilm-associated disease, is a prevalent oral health problem. It is a bacterial biofilm-associated disease. Conventional means of combating this disease involves oral hygiene, mostly tooth brushing. Supplementary means of prevention and treatment is often necessary. The use of sustained-release delivery systems, locally applied to the oral cavity appears to be one of the most acceptable avenues for the delivery of antimicrobial agents. Area covered: The development and current approaches of local sustained delivery technologies applied to the oral cavity for treatment and prevention of dental caries is discussed. The use of polymeric drug delivery systems, varnishes, liposomes and nanoparticles is presented. Expert opinion: The use of local sustained-release delivery systems applied to the oral cavity has numerous clinical, pharmacological and toxicological advantages over conventional means. Various sustained-release technologies have been suggested over the course of several years. The current research on oral diseases concentrates predominantly on improving the drug delivery. With progress in pharmaceutical technology, sophisticated controlled-release platforms are being developed. The sustained release concept is innovative and there are few products available for the benefit of all populations. Harmonizing academic research with the dental industry will surely expedite the development and commercialization of more products of such pharmacological nature.
authors.affiliation: a Biofilm Research Laboratory, Institute of Dental Sciences , Hebrew University-Hadassah , Jerusalem , Israel.
authors.forename: Doron
authors.initials: D
authors.lastname: Steinberg
authors.affiliation: b Institute for Drug Research, School of Pharmacy , Hebrew University , Jerusalem , Israel.
authors.forename: Michael
authors.initials: M
authors.lastname: Friedman
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage*; D018441:Biofilms / Q000187:drug effects; D003692:Delayed-Action Preparations; D003731:Dental Caries / Q000517:prevention & control*; D016503:Drug Delivery Systems; D006801:Humans; D009055:Mouth
chemical_list: D000890:Anti-Infective Agents; D003692:Delayed-Action Preparations
keywords: Dental sustained-release delivery system; antibacterial agents; dental biofilm; dental caries; dental plaque; oral cavity