title: Mitochondrial lipids in neurodegeneration.
abstract: Mitochondrial dysfunction is a common feature of many neurodegenerative diseases, including proteinopathies such as Alzheimer's or Parkinson's disease, which are characterized by the deposition of aggregated proteins in the form of insoluble fibrils or plaques. The distinct molecular processes that eventually result in mitochondrial dysfunction during neurodegeneration are well studied but still not fully understood. However, defects in mitochondrial fission and fusion, mitophagy, oxidative phosphorylation and mitochondrial bioenergetics have been linked to cellular demise. These processes are influenced by the lipid environment within mitochondrial membranes as, besides membrane structure and curvature, recruitment and activity of different proteins also largely depend on the respective lipid composition. Hence, the interaction of neurotoxic proteins with certain lipids and the modification of lipid composition in different cell compartments, in particular mitochondria, decisively impact cell death associated with neurodegeneration. Here, we discuss the relevance of mitochondrial lipids in the pathological alterations that result in neuronal demise, focussing on proteinopathies.
authors.affiliation: Institute of Molecular Biosciences, University of Graz, Humboldtstraße 50, 8010, Graz, Austria.
authors.forename: Andreas
authors.initials: A
authors.lastname: Aufschnaiter
authors.affiliation: Institute of Molecular Biosciences, University of Graz, Humboldtstraße 50, 8010, Graz, Austria.
authors.forename: Verena
authors.initials: V
authors.lastname: Kohler
authors.affiliation: Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Svante Arrheniusväg 20C, 106 91, Stockholm, Sweden.
authors.forename: Jutta
authors.initials: J
authors.lastname: Diessl
authors.affiliation: Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Svante Arrheniusväg 20C, 106 91, Stockholm, Sweden.
authors.forename: Carlotta
authors.initials: C
authors.lastname: Peselj
authors.affiliation: Institute of Molecular Biosciences, University of Graz, Humboldtstraße 50, 8010, Graz, Austria.
authors.forename: Didac
authors.initials: D
authors.lastname: Carmona-Gutierrez
authors.affiliation: Institute of Molecular Biosciences, University of Graz, Humboldtstraße 50, 8010, Graz, Austria.
authors.forename: Walter
authors.initials: W
authors.lastname: Keller
authors.affiliation: Institute of Molecular Biosciences, University of Graz, Humboldtstraße 50, 8010, Graz, Austria. sabrina.buettner@su.se.|Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Svante Arrheniusväg 20C, 106 91, Stockholm, Sweden. sabrina.buettner@su.se.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Büttner
mesh_terms: D000818:Animals; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D008928:Mitochondria / Q000378:metabolism*; D051336:Mitochondrial Membranes / Q000378:metabolism; D063306:Mitophagy; D008954:Models, Biological; D009410:Nerve Degeneration / Q000378:metabolism* / Q000473:pathology
chemical_list: D008055:Lipids
keywords: Lipids; Mitochondria; Mitochondria-associated membranes; Mitochondrial dynamics; Neurodegeneration