title: The Independent Importance of Pre-pregnancy Weight and Gestational Weight Gain for the Prevention of Large-for Gestational Age Brazilian Newborns.
abstract: Objectives To study the independent effect of pre-pregnancy weight, gestational weight gain (GWG), and other important risk factors on newborn birth weight. Methods Baseline data of 435 adult women and their singletons born between January and February 2012 at a public hospital in Brazil were used. Logistic regression was applied to determine the independent importance of pre-pregnancy weight and GWG for large for gestational age (LGA) newborns. Results Among all mothers, 37.9 % were overweight and obese before pregnancy and 45.3 % experienced excessive GWG. Among the newborns, 24.4 % were classified as LGA. Univariate analysis showed an association of family income, GWG, pre-pregnancy BMI and excessive GWG with LGA newborns. Smoking before and during pregnancy was associated with a decreased likelihood of giving birth to an LGA newborn compared to mothers who did not smoke. After adjustment for confounding variables, age at birth of first child, GWG, HbA1c and pre-pregnancy weight-GWG were significant and independent determinants of giving birth to an LGA newborn. Mothers with pre-pregnancy overweight and excessive GWG were more likely to deliver an LGA newborn (OR 2.54, P < 0.05) compared to mothers who were normal weight and experienced adequate GWG. Conclusions for Practice Age at first birth of child, GWG, HbA1c and pre-pregnancy overweight combined with excessive GWG are independent determinants of LGA newborns. The results of this study suggest that both primary prevention of overweight in women of childbearing age and management of GWG may be important strategies to reduce the number of LGA newborns and, consequently, the long-term public health burden of obesity.
authors.affiliation: Post-graduation Program in Health and Environment, University of Joinville Region, Rua Paulo Malschitzki, No 10, Joinville, SC, CEP 89.219-710, Brazil. marco.mastroeni@univille.br.|Department of Biological Sciences, University of Joinville Region, Rua Paulo Malschitzki, No 10, Joinville, SC, CEP 89.219-710, Brazil. marco.mastroeni@univille.br.|Population Health Intervention Research Unit, School of Public Health, University of Alberta, 3-50 University Terrace, 8303 - 112 St, Edmonton, AB, T6G 2T4, Canada. marco.mastroeni@univille.br.
authors.forename: Marco F
authors.identifier: 0000-0001-9276-8866
authors.initials: MF
authors.lastname: Mastroeni
authors.affiliation: Post-graduation Program in Health and Environment, University of Joinville Region, Rua Paulo Malschitzki, No 10, Joinville, SC, CEP 89.219-710, Brazil.
authors.forename: Sandra A
authors.initials: SA
authors.lastname: Czarnobay
authors.affiliation: Department of Biological Sciences, University of Joinville Region, Rua Paulo Malschitzki, No 10, Joinville, SC, CEP 89.219-710, Brazil.
authors.forename: Caroline
authors.initials: C
authors.lastname: Kroll
authors.affiliation: Post-graduation Program in Health and Environment, University of Joinville Region, Rua Paulo Malschitzki, No 10, Joinville, SC, CEP 89.219-710, Brazil.
authors.forename: Katherinne B W
authors.initials: KB
authors.lastname: Figueirêdo
authors.affiliation: Department of Physical Education, University of Joinville Region, Rua Paulo Malschitzki, No 10, Joinville, SC, CEP 89.219-710, Brazil.|Population Health Intervention Research Unit, School of Public Health, University of Alberta, 3-50 University Terrace, 8303 - 112 St, Edmonton, AB, T6G 2T4, Canada.
authors.forename: Silmara S B S
authors.initials: SS
authors.lastname: Mastroeni
authors.affiliation: Post-graduation Program in Health and Environment, University of Joinville Region, Rua Paulo Malschitzki, No 10, Joinville, SC, CEP 89.219-710, Brazil.
authors.forename: Jean C
authors.initials: JC
authors.lastname: Silva
authors.affiliation: Population Health Intervention Research Unit, School of Public Health, University of Alberta, 3-50 University Terrace, 8303 - 112 St, Edmonton, AB, T6G 2T4, Canada.
authors.forename: Mohammad K A
authors.initials: MK
authors.lastname: Khan
authors.affiliation: Population Health Intervention Research Unit, School of Public Health, University of Alberta, 3-50 University Terrace, 8303 - 112 St, Edmonton, AB, T6G 2T4, Canada.
authors.forename: Sarah
authors.initials: S
authors.lastname: Loehr
authors.affiliation: Population Health Intervention Research Unit, School of Public Health, University of Alberta, 3-50 University Terrace, 8303 - 112 St, Edmonton, AB, T6G 2T4, Canada.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Veugelers
mesh_terms: D000328:Adult; D001724:Birth Weight; D015992:Body Mass Index; D001938:Brazil; D005260:Female; D005320:Fetal Macrosomia / Q000209:etiology* / Q000517:prevention & control*; D006801:Humans; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D050177:Overweight / Q000150:complications*; D011247:Pregnancy; D037841:Pregnant People; D012307:Risk Factors; D015430:Weight Gain
keywords: Birth weight; Gestational weight gain; Large-for-gestational-age; Obesity; Pre-pregnancy weight