title: Multifocal tuberculous osteomyelitis in a 3-year-old child.
abstract: Multifocal skeletal tuberculosis accounts for less than 1% of all tuberculous lesions in children. A 3-year-old unimmunised child presented with painless symmetrical swelling of both arms, pallor and hepatosplenomegaly. A skeletal survey demonstrated lytic lesions of the metadiaphysis of both humeri, a rib and the sacrum. The possibility of Langerhans cell histiocytosis or multifocal fibrous dysplasia was considered; however, acid-fast bacilli were detected in the biopsy specimen and real-time polymerase chain reaction confirmed Mycobacterium tuberculosis infection. Culture for M. tuberculosis was negative. The patient responded to anti-tuberculous therapy.
authors.affiliation: a Departments of Paediatrics , University College of Medical Sciences and Guru Teg Bahadur Hospital , Delhi , India.
authors.forename: Pooja
authors.initials: P
authors.lastname: Dewan
authors.affiliation: b Departments of Radiology , University College of Medical Sciences and Guru Teg Bahadur Hospital , Delhi , India.
authors.forename: Anupama
authors.initials: A
authors.lastname: Tandon
authors.affiliation: a Departments of Paediatrics , University College of Medical Sciences and Guru Teg Bahadur Hospital , Delhi , India.
authors.forename: Smriti
authors.initials: S
authors.lastname: Rohatgi
authors.affiliation: b Departments of Radiology , University College of Medical Sciences and Guru Teg Bahadur Hospital , Delhi , India.
authors.forename: Shuaib
authors.initials: S
authors.lastname: Qureshi
mesh_terms: D000995:Antitubercular Agents / Q000008:administration & dosage; D001706:Biopsy; D002675:Child, Preschool; D003584:Cytological Techniques; D005260:Female; D006801:Humans; D008853:Microscopy; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification*; D010019:Osteomyelitis / Q000175:diagnosis* / Q000473:pathology*; D060888:Real-Time Polymerase Chain Reaction; D016896:Treatment Outcome; D014376:Tuberculosis / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology*
chemical_list: D000995:Antitubercular Agents
keywords: Bone; Child; Lytic; Multifocal; Tuberculosis