title: [Hypovolemic hyponatremia at the onset of severe ischemic stroke as a predictor of adverse outcome].
abstract: OBJECTIVE
  To study the prognostic value of disturbances of the water and electrolyte homeostasis in the acute stage of ischemic stroke (II) and their impact on the course and outcome.
  
  
  METHODS
  Disturbances of the water and electrolyte homeostasis associated with plasma sodium fluctuations were studied in 150 patients with severe II.
  
  
  RESULTS
  The poor outcome was associated with plasma osmolarity >297 mOsmol/L and plasma sodium concentration >155 mOsmol/L in the first day of severe II and with >303 mOsmol/L and >161 mOsmol/L, respectively, in the 3rd and 5th days. The prognosis was significantly worse in hypovolemia compared to normo- and hypervolemia.
  
  
  CONCLUSIONS
  Hypovolemic hyponatremia as a presentation of hyperosmolar syndrome at the onset of severe II can be considered as a relatedly independent predictor of the fatal outcome.
authors.affiliation: Orenburg State Medical Academy, Orenburg, Russia.
authors.forename: V I
authors.initials: VI
authors.lastname: Ershov
authors.affiliation: Orenburg State Medical Academy, Orenburg, Russia.
authors.forename: A N
authors.initials: AN
authors.lastname: Chirkov
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000175:diagnosis* / Q000209:etiology*; D020896:Hypovolemia / Q000097:blood / Q000150:complications*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012964:Sodium / Q000097:blood; D020521:Stroke / Q000097:blood / Q000150:complications* / Q000175:diagnosis*
chemical_list: D012964:Sodium