title: Deciphering and modifying LAFL transcriptional regulatory network in seed for improving yield and quality of storage compounds.
abstract: Increasing yield and quality of seed storage compounds in a sustainable way is a key challenge for our societies. Genome-wide analyses conducted in both monocot and dicot angiosperms emphasized drastic transcriptional switches that occur during seed development. In Arabidopsis thaliana, a reference species, genetic and molecular analyses have demonstrated the key role of LAFL (LEC1, ABI3, FUS3, and LEC2) transcription factors (TFs), in controlling gene expression programs essential to accomplish seed maturation and the accumulation of storage compounds. Here, we summarize recent progress obtained in the characterization of these LAFL proteins, their regulation, partners and target genes. Moreover, we illustrate how these evolutionary conserved TFs can be used to engineer new crops with altered seed compositions and point out the current limitations. Last, we discuss about the interest of investigating further the environmental and epigenetic regulation of this network for the coming years.
authors.affiliation: IJPB, INRA, AgroParisTech, CNRS, Université Paris-Saclay, RD10, 78026, Versailles Cedex, France. Electronic address: Abdelhak.Fatihi@versailles.inra.fr.
authors.forename: Abdelhak
authors.initials: A
authors.lastname: Fatihi
authors.affiliation: IJPB, INRA, AgroParisTech, CNRS, Université Paris-Saclay, RD10, 78026, Versailles Cedex, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Boulard
authors.affiliation: Institut de Biologie de l'ENS, CNRS UMR8197, Ecole Normale Supérieure, 46 rue d'Ulm, 75230, Paris cedex 05, France.
authors.forename: Daniel
authors.initials: D
authors.lastname: Bouyer
authors.affiliation: IJPB, INRA, AgroParisTech, CNRS, Université Paris-Saclay, RD10, 78026, Versailles Cedex, France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Baud
authors.affiliation: IJPB, INRA, AgroParisTech, CNRS, Université Paris-Saclay, RD10, 78026, Versailles Cedex, France.
authors.forename: Bertrand
authors.initials: B
authors.lastname: Dubreucq
authors.affiliation: IJPB, INRA, AgroParisTech, CNRS, Université Paris-Saclay, RD10, 78026, Versailles Cedex, France. Electronic address: Loic.Lepiniec@versailles.inra.fr.
authors.forename: Loïc
authors.initials: L
authors.lastname: Lepiniec
mesh_terms: D017360:Arabidopsis / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D029681:Arabidopsis Proteins / Q000235:genetics* / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D018506:Gene Expression Regulation, Plant; D053263:Gene Regulatory Networks; D012639:Seeds / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism
chemical_list: D029681:Arabidopsis Proteins; D014157:Transcription Factors
keywords: LAFL network; Oil; Seed development; Seed maturation; Seed storage proteins; Transcriptional regulation