title: Correlation study between small vessel disease and early neurological deterioration in patients with mild/moderate acute ischemic stroke.
abstract: OBJECTIVE
  Cerebral small vessel disease (SVD) refers to a group of pathological processes that affect small arteries, arterioles, venules, and capillaries of the brain. We hypothesized that imaging markers of SVD could be associated with neurological deterioration during acute phase of mild/moderate ischemic stroke.
  
  
  METHODS
  We performed a prospective cohort with 687 consecutive patients with acute ischemic stroke and also with admission NIHSS score below 12 points. Imaging markers of SVD include silent lacunar infarction, deep cerebral microbleeds (CMBs), brain atrophy, periventricular and semiovale white matter hyperintensities, basal ganglia and semiovale enlarged perivascular spaces as well as SVD burden rating scale, which were evaluated and calculated, respectively. Early neurology deterioration (END) was defined as an increment of NIHSS score ≥2 points in the first 72 h after admission.
  
  
  RESULTS
  None of these imaging markers and rating scale of SVD significantly correlated with END after adjusted for major confounders. Post hoc analysis indicated similar negative results in different age, TOAST classification and infarction location subgroups. Only silent infarction (OR 2.42, 95%CI 1.33-5.10) and deep CMBs (OR 2.10, 95%CI 1.08-3.72) seemed to be predictors for END in female patients. However, due to the increased type I error in multiple comparisons, these relationships should not be regarded as statistically significant.
  
  
  CONCLUSIONS
  In patients with mild/moderate acute ischemic stroke, imaging markers of SVD did not correlate with END.
authors.affiliation: a Department of Neurology , Jinling Hospital, Southern Medical University , Nanjing , Jiangsu , China.|b Department of Neurology , Mianyang central Hospital , Mianyang , Sichuan , China.
authors.forename: Zhonglun
authors.initials: Z
authors.lastname: Chen
authors.affiliation: a Department of Neurology , Jinling Hospital, Southern Medical University , Nanjing , Jiangsu , China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: a Department of Neurology , Jinling Hospital, Southern Medical University , Nanjing , Jiangsu , China.
authors.forename: Wen
authors.initials: W
authors.lastname: Sun
authors.affiliation: a Department of Neurology , Jinling Hospital, Southern Medical University , Nanjing , Jiangsu , China.
authors.forename: Lulu
authors.initials: L
authors.lastname: Xiao
authors.affiliation: a Department of Neurology , Jinling Hospital, Southern Medical University , Nanjing , Jiangsu , China.
authors.forename: Qiliang
authors.initials: Q
authors.lastname: Dai
authors.affiliation: a Department of Neurology , Jinling Hospital, Southern Medical University , Nanjing , Jiangsu , China.
authors.forename: Yuezhou
authors.initials: Y
authors.lastname: Cao
authors.affiliation: a Department of Neurology , Jinling Hospital, Southern Medical University , Nanjing , Jiangsu , China.
authors.forename: Yunfei
authors.initials: Y
authors.lastname: Han
authors.affiliation: a Department of Neurology , Jinling Hospital, Southern Medical University , Nanjing , Jiangsu , China.
authors.forename: Wusheng
authors.initials: W
authors.lastname: Zhu
authors.affiliation: a Department of Neurology , Jinling Hospital, Southern Medical University , Nanjing , Jiangsu , China.
authors.forename: Gelin
authors.initials: G
authors.lastname: Xu
authors.affiliation: a Department of Neurology , Jinling Hospital, Southern Medical University , Nanjing , Jiangsu , China.
authors.forename: Xinfeng
authors.initials: X
authors.lastname: Liu
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000175:diagnosis* / Q000503:physiopathology; D059345:Cerebral Small Vessel Diseases / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000175:diagnosis* / Q000503:physiopathology
keywords: brain atrophy; cerebral microbleeds; early neurological deterioration; enlarged perivascular spaces; small vessel disease; white matter hyperintensities