title: A Software App for Radiotherapy with In-situ Dose-painting using high Z nanoparticles.
abstract: The purpose of this work is to develop an user friendly and free-to-download application software that can be employed for modeling Radiotherapy with In-situ Dose-painting (RAID) using high-Z nanoparticles (HZNPs). The RAID APP is software program written in Matlab (Mathworks, Natick, MA, USA) based on deterministic code developed to simulate the space-time intra-tumor HZNPs biodistribution within the tumor, and the corresponding dose enhancement in response to low dose rate (LDR) brachytherapy of I-125, Pd-102, Cs-131 and kilovoltage x-rays such as 50 keV and 100 keV. Through the GUI of RAID APP, the user will be directed to different features to compute various parameters related to the dose enhancement and the biodistribution of NPs within high risk tumor sub-volumes. The software was developed as tool for research purposes with potential for subsequent development to guide dose-painting treatment planning using radiosensitizers such as gold (Au) and platinum (Pt).
authors.affiliation: Department of Physics and Applied Physics, Medical Physics Program, University of Massachusetts Lowell, MA USA; Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
authors.forename: M
authors.initials: M
authors.lastname: Jermoumi
authors.affiliation: Department of Physics and Applied Physics, Medical Physics Program, University of Massachusetts Lowell, MA USA.
authors.forename: A
authors.initials: A
authors.lastname: Yucel
authors.affiliation: Department of Physics and Applied Physics, Medical Physics Program, University of Massachusetts Lowell, MA USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Hao
authors.affiliation: Department of Physics and Applied Physics, Medical Physics Program, University of Massachusetts Lowell, MA USA; Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
authors.forename: G
authors.initials: G
authors.lastname: Cifter
authors.affiliation: Department of Physics and Applied Physics, Medical Physics Program, University of Massachusetts Lowell, MA USA.
authors.forename: E
authors.initials: E
authors.lastname: Sajo
authors.affiliation: Department of Physics and Applied Physics, Medical Physics Program, University of Massachusetts Lowell, MA USA; Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
authors.forename: W
authors.initials: W
authors.lastname: Ngwa
keywords: Dose painting; dose enhancement; high atomic number nanoparticles