title: World Health Organization Group I Pulmonary Hypertension: Epidemiology and Pathophysiology.
abstract: Pulmonary arterial hypertension (PAH) is a debilitating disease characterized by pathologic remodeling of the resistance pulmonary arteries, ultimately leading to right ventricular (RV) failure and death. In this article we discuss the definition of PAH, the initial epidemiology based on the National Institutes of Health Registry, and the updated epidemiology gleaned from contemporary registries, pathogenesis of pulmonary vascular dysfunction and proliferation, and RV failure in PAH.
authors.affiliation: Cardiovascular Division, University of Minnesota Medical School, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA.
authors.forename: Kurt W
authors.initials: KW
authors.lastname: Prins
authors.affiliation: Section of Advanced Heart Failure and Pulmonary Hypertension, Cardiovascular Division, University of Minnesota Medical School, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA. Electronic address: tthenapp@umn.edu.
authors.forename: Thenappan
authors.initials: T
authors.lastname: Thenappan
mesh_terms: D014943:Global Health; D006801:Humans; D006976:Hypertension, Pulmonary / Q000145:classification / Q000453:epidemiology / Q000503:physiopathology; D009017:Morbidity / Q000639:trends; D011669:Pulmonary Wedge Pressure / Q000502:physiology*; D016278:Ventricular Function, Right / Q000502:physiology*; D014944:World Health Organization
keywords: Epidemiology; Pathophysiology; Pulmonary arterial hypertension; Pulmonary vasculature; Right ventricle