title: [Distribution characteristics of rs1891385A/C and rs10975519C/T polymorphisms of interleukin-33 gene in Guangxi population].
abstract: OBJECTIVE
  To explore the race- and gender-specific distribution characteristics of rs1891385A/C and rs10975519C/T polymorphism of interleukin-33 (IL-33) gene in Zhuang and Han populations.
  
  
  METHODS
  The polymorphisms of rs1891385A/C and rs10975519C/T of IL-33 gene in 283 subjects from Guangxi Zhuang Autonomous Region were analyzed with single base extension (PCR-SEB) and DNA sequencing to analyze the differences in their distribution frequencies between genders and between Zhuang and Han populations.
  
  
  RESULTS
  Three genotypes (AA, AC and CC) were found in rs1891385A/C with frequencies of 64.3%, 32.5% and 3.2%, respectively. The genotype and allele frequencies of rs1891385A/C in this Guangxi population showed no significant difference between Zhuang and Han subpopulations and between genders (P>0.05), but differed significantly from those in European and African black populations (P<0.01). Three genotypes (CC, CT and TT) were identified in rs10975519C/T with frequencies of 34.3%, 53.0%, and 12.7%, respectively, showing no significant ethnic or gender-specific differences in this population (P>0.05). The genotype frequency of rs10975519C/T in this population differed significantly from those in the European and Japanese populations (P<0.01), but the allele frequencies only showed significant differences from those in the European population (P<0.01).
  
  
  CONCLUSIONS
  rs1891385A/C and rs10975519C/T polymorphisms of IL-33 gene show a race-specific difference.
authors.affiliation: Department of Dermatology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, China.E-mail: gjnsdy-1987@163.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Guo
authors.forename: Yang
authors.initials: Y
authors.lastname: Xiang
authors.forename: Hua-Tuo
authors.initials: HT
authors.lastname: Huang
authors.forename: You-Fan
authors.initials: YF
authors.lastname: Peng
authors.forename: Ye-Sheng
authors.initials: YS
authors.lastname: Wei
authors.forename: Yan
authors.initials: Y
authors.lastname: Lan
mesh_terms: D044466:Asian People / Q000235:genetics*; D044383:Black People / Q000235:genetics; D002681:China; D005006:Ethnicity / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D000067596:Interleukin-33 / Q000235:genetics*; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA; D044465:White People / Q000235:genetics
chemical_list: D000067596:Interleukin-33