title: Salivary Gland Pathology in Sjögren's Syndrome.
abstract: Primary Sjögren syndrome (pSS) can be considered a systemic autoimmune disease with a strong organ bias. The involvement of the exocrine glands is prevalent and drives the pathognomonic manifestations of dryness that define the sicca syndrome. The salivary glands also represent the hub of pSS pathology. Elements belonging to both innate and acquired immune responses have been described at this site that contribute to disease establishment and progression. The interaction between those elements and their relative contributions to the clinical manifestations and lymphoma progression largely remain to be addressed.
authors.affiliation: Centre for Translational Inflammation Research, Institute of Inflammation and Ageing, ARUK Center for the Pathogenesis of Rheumatoid Arthritis, University of Birmingham, Queen Elizabeth Hospital, Mindelsohn Way, Birmingham B15 2WB, UK.
authors.forename: Joana
authors.initials: J
authors.lastname: Campos
authors.affiliation: Centre for Translational Inflammation Research, Institute of Inflammation and Ageing, ARUK Center for the Pathogenesis of Rheumatoid Arthritis, University of Birmingham, Queen Elizabeth Hospital, Mindelsohn Way, Birmingham B15 2WB, UK; Laboratory of Translational Immunology, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht 3584CX, The Netherlands.
authors.forename: Maarten R
authors.initials: MR
authors.lastname: Hillen
authors.affiliation: Centre for Translational Inflammation Research, Institute of Inflammation and Ageing, ARUK Center for the Pathogenesis of Rheumatoid Arthritis, University of Birmingham, Queen Elizabeth Hospital, Mindelsohn Way, Birmingham B15 2WB, UK. Electronic address: f.barone@bham.ac.uk.
authors.forename: Francesca
authors.initials: F
authors.lastname: Barone
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology* / Q000473:pathology; D018858:Germinal Center / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007370:Interferon Type I / Q000276:immunology*; D016393:Lymphoma, B-Cell; D012468:Salivary Gland Neoplasms; D012469:Salivary Glands / Q000276:immunology* / Q000473:pathology; D012859:Sjogren's Syndrome / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology
chemical_list: D007370:Interferon Type I
keywords: Autoimmune disease; Histopathology; Primary Sjögren's syndrome; Salivary glands