title: The evaluation of the synergistic effect of 3-(2,4-dihydroxyphenyl)propionic acid and l-ascorbic acid on tyrosinase inhibition.
abstract: 3-(2,4-Dihydroxyphenyl)propionic acid (DDPA) and l-ascorbic acid (vitamin C) show tyrosinase inhibition activity. A synergistic effect on tyrosinase inhibition was observed when the two compounds were mixed. The effect significantly decreased the IC50 value of both compounds.
authors.affiliation: Faculty of Agriculture, Kochi University, Nankoku, Japan.
authors.forename: Xinyang
authors.initials: X
authors.lastname: Chen
authors.affiliation: Faculty of Agriculture, Kochi University, Nankoku, Japan.
authors.forename: Aya
authors.initials: A
authors.lastname: Haniu
authors.affiliation: Faculty of Agriculture, Kochi University, Nankoku, Japan.
authors.forename: Takehiro
authors.initials: T
authors.lastname: Kashiwagi
authors.affiliation: Faculty of Nutrition, University of Kochi, Kochi, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Watanabe
authors.affiliation: Department of Medicinal Plant, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Watanabe
authors.affiliation: Kochi Prefectural Industrial Technology Center, Nankoku, Japan.
authors.forename: Yoshino
authors.initials: Y
authors.lastname: Okamoto
authors.affiliation: Kochi Prefectural Industrial Technology Center, Nankoku, Japan.
authors.forename: Masanobu
authors.initials: M
authors.lastname: Suzuki
authors.affiliation: Faculty of Agriculture, Kochi University, Nankoku, Japan.
authors.forename: Chul-Sa
authors.initials: CS
authors.lastname: Kim
mesh_terms: D000363:Agaricales / Q000737:chemistry / Q000201:enzymology; D001205:Ascorbic Acid / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004791:Enzyme Inhibitors / Q000737:chemistry*; D005656:Fungal Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000302:isolation & purification; D007700:Kinetics; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000302:isolation & purification; D010084:Oxidation-Reduction; D010666:Phenylpropionates / Q000737:chemistry*
chemical_list: C520847:3-(2,4-dihydroxyphenyl)propionic acid; D004791:Enzyme Inhibitors; D005656:Fungal Proteins; D010666:Phenylpropionates; D014442:Monophenol Monooxygenase; D001205:Ascorbic Acid