title: Investigation of Pharmacological Activity of Caralluma penicillata: Anti-Inflammatory Properties and Gastritis Protection against Indomethacin in Adult Guinea Pigs.
abstract: Caralluma is a plant that possessing a great therapeutic potential in folk medicine in Yemen, namely, Caralluma penicillata (C. penicillata) as antiulcer. The study aims to evaluate the anti-inflammatory properties and gastritis protection activity of C. penicillata against indomethacin in adult guinea pigs. The study was divided into four parts: firstly, the optimum dose of extract as anti-inflammatory effect was determined. Secondly, the acute anti-inflammatory effect of extract were estimated. Thirdly, the repeated doses of extract against chronic inflammation was estimated. The anti-inflammatory activity of extract was compared with indomethacin as a prototype of drug against inflammation. Fourthly, the gastritis protection properties of extract with/without indomethacin were performed. The results showed that a 400 mg/kg of 10% ethanol extract produced the maximum of anti-inflammatory effect. Also, the single dose of extract was equipotent for indomethacin (10 mg/kg), but shorter in duration with regard to acute anti-inflammatory effect. In addition, the repeated doses of extract against chronic inflammation were less potent than indomethacin with regard to ulcerogenic effect. On the other hand, extract-indomethacin combination reduced the gastritis effect of indomethacin based on ulcer index and histological study.
authors.affiliation: Department of Pharmacology and Therapeutic, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen; Tihama Foundation for Drug Studies and Research, Hodeidah, Yemen.
authors.forename: Nabil
authors.initials: N
authors.lastname: Albaser
authors.affiliation: Department of Pharmacology and Therapeutic, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen; Tihama Foundation for Drug Studies and Research, Hodeidah, Yemen.
authors.forename: Najeeb
authors.initials: N
authors.lastname: Ghanem
authors.affiliation: Department of Pharmacology and Therapeutic, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen.
authors.forename: Mohanad
authors.initials: M
authors.lastname: Shehab
authors.affiliation: Department of Pharmacology and Therapeutic, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen; Tihama Foundation for Drug Studies and Research, Hodeidah, Yemen.
authors.forename: Adnan
authors.initials: A
authors.lastname: Al-Adhal
authors.affiliation: Tihama Foundation for Drug Studies and Research, Hodeidah, Yemen; Department of Pharmacy Practice, Faculty of Clinical Pharmacy, Hodeidah University, P.O. Box 3114, Hodeidah, Yemen.
authors.forename: Mohammed
authors.identifier: 0000-0002-0791-8602
authors.initials: M
authors.lastname: Amood Al-Kamarany