title: NHX-5, an Endosomal Na+/H+ Exchanger, Is Associated with Metformin Action.
abstract: Diabetes is one of the most impactful diseases worldwide. The most commonly prescribed anti-diabetic drug is metformin. In this study, we identified an endosomal Na(+)/H(+) exchanger (NHE) as a new potential target of metformin from an unbiased screen in Caenorhabditis elegans The same NHE homolog also exists in flies, where it too mediates the effects of metformin. Our results suggest that endosomal NHEs could be a metformin target and provide an insight into a novel mechanism of action of metformin on regulating the endocytic cycle.
authors.affiliation: From the Department of Biological Sciences, Inha University, Incheon 22212, South Korea.
authors.forename: Jeongho
authors.initials: J
authors.lastname: Kim
authors.affiliation: From the Department of Biological Sciences, Inha University, Incheon 22212, South Korea.
authors.forename: Hye-Yeon
authors.initials: HY
authors.lastname: Lee
authors.affiliation: the Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, Virginia 23298, and.
authors.forename: Jheesoo
authors.initials: J
authors.lastname: Ahn
authors.affiliation: the Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, Virginia 23298, and.
authors.forename: Moonjung
authors.initials: M
authors.lastname: Hyun
authors.affiliation: the Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, Virginia 23298, and.
authors.forename: Inhwan
authors.initials: I
authors.lastname: Lee
authors.affiliation: From the Department of Biological Sciences, Inha University, Incheon 22212, South Korea.
authors.forename: Kyung-Jin
authors.initials: KJ
authors.lastname: Min
authors.affiliation: the Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, Virginia 23298, and the Nagoya Research Center for Brain & Neural Circuits, Graduate School of Science, Nagoya University, Nagoya 464-8602, Japan yjyou@bio.nagoya-u.ac.jp.
authors.forename: Young-Jai
authors.initials: YJ
authors.lastname: You
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics / Q000378:metabolism*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism*; D011992:Endosomes / Q000235:genetics / Q000378:metabolism*; D008687:Metformin / Q000493:pharmacokinetics / Q000494:pharmacology; D017923:Sodium-Hydrogen Exchangers / Q000235:genetics / Q000378:metabolism*
chemical_list: D029742:Caenorhabditis elegans Proteins; D017923:Sodium-Hydrogen Exchangers; D008687:Metformin
keywords: Caenorhabditis elegans (C. elegans); Type 2 diabetes; autophagy; drug action; endosome; metformin; sodium-proton exchange