title: Preparation of Chito-Oligomers by Hydrolysis of Chitosan in the Presence of Zeolite as Adsorbent.
abstract: An increasing interest has recently been shown to use chitin/chitosan oligomers (chito-oligomers) in medicine and food fields because they are not only water-soluble, nontoxic, and biocompatible materials, but they also exhibit numerous biological properties, including antibacterial, antifungal, and antitumor activities, as well as immuno-enhancing effects on animals. Conventional depolymerization methods of chitosan to chito-oligomers are either chemical by acid-hydrolysis under harsh conditions or by enzymatic degradation. In this work, hydrolysis of chitosan to chito-oligomers has been achieved by applying adsorption-separation technique using diluted HCl in the presence of different types of zeolite as adsorbents. The chito-oligomers were retrieved from adsorbents and characterized by differential scanning calorimetry (DSC), liquid chromatography/mass spectroscopy (LC/MS), and ninhydrin test.
authors.affiliation: Department of Chemical Engineering, Faculty of Engineering, Al-Hussein Bin Talal University, P.O. Box 20, Ma`an 71111, Jordan. khalida@ahu.edu.jo.|College of Engineering, King Saud University, P.O. Box 800, Riyadh 11421, Saudi Arabia. khalida@ahu.edu.jo.
authors.forename: Khalid A
authors.initials: KA
authors.lastname: Ibrahim
authors.affiliation: Department of Basic Sciences, Zarqa College, Al-Balqa Applied University, P.O. Box 313, Zarqa 13110, Jordan. bassameswed@bau.edu.jo.
authors.forename: Bassam I
authors.initials: BI
authors.lastname: El-Eswed
authors.affiliation: Department of Chemistry, Faculty of Science, Al-Hussein Bin Talal University, P.O. Box 20, Ma`an 71111, Jordan. abusbeih@ahu.edu.jo.
authors.forename: Khaleel A
authors.initials: KA
authors.lastname: Abu-Sbeih
authors.affiliation: Department of Pharmaceutical Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy and Medical Technology, Petra University, P.O. Box 961343, Amman 11196, Jordan. tarafat@uop.edu.jo.
authors.forename: Tawfeeq A
authors.initials: TA
authors.lastname: Arafat
authors.affiliation: Research and Innovation Center (RIC), The Jordanian Pharmaceutical Manufacturing Co., P.O. Box 94, Naor 11710, Jordan. momari@jpm.com.jo.
authors.forename: Mahmoud M H
authors.initials: MM
authors.lastname: Al Omari
authors.affiliation: Research and Innovation Center (RIC), The Jordanian Pharmaceutical Manufacturing Co., P.O. Box 94, Naor 11710, Jordan. fdarras@jpm.com.jo.
authors.forename: Fouad H
authors.initials: FH
authors.lastname: Darras
authors.affiliation: The Jordanian Pharmaceutical Manufacturing Co., P.O. Box 94, Naor 11710, Jordan. jpm@go.com.jo.
authors.forename: Adnan A
authors.initials: AA
authors.lastname: Badwan
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry; D000935:Antifungal Agents / Q000737:chemistry; D000970:Antineoplastic Agents / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D002686:Chitin / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D002853:Chromatography, Liquid; D006851:Hydrochloric Acid / Q000737:chemistry; D006868:Hydrolysis; D007202:Indicators and Reagents / Q000737:chemistry; D013058:Mass Spectrometry; D009555:Ninhydrin / Q000737:chemistry; D017641:Zeolites / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D007202:Indicators and Reagents; D017641:Zeolites; D002686:Chitin; D048271:Chitosan; D009555:Ninhydrin; D006851:Hydrochloric Acid
keywords: chito-oligomers; chitosan; depolymerization; hydrolysis; zeolite