title: Preparation of Targeted Anionic Lipid-Coated Polyplexes for MicroRNA Delivery.
abstract: As nonviral nucleic acid delivery vehicles, lipid nanoparticles (LNPs) have been widely used. Here we describe the synthesis and evaluation of LNPs based on targeted anionic lipid-coated polyplexs for therapeutic delivery of microRNA (miRNA) mimics. These LNPs are particularly suited for therapeutic delivery of oligonucleotide agents to leukemia cells.
authors.affiliation: Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, 500 W. 12th Avenue, Columbus, OH, 43210, USA.
authors.forename: Xiaomeng
authors.initials: X
authors.lastname: Huang
authors.affiliation: Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, 500 W. 12th Avenue, Columbus, OH, 43210, USA.
authors.forename: Mengzi
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, 500 W. 12th Avenue, Columbus, OH, 43210, USA.
authors.forename: Xinmei
authors.initials: X
authors.lastname: Wang
authors.affiliation: Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, 500 W. 12th Avenue, Columbus, OH, 43210, USA.
authors.forename: L James
authors.initials: LJ
authors.lastname: Lee
authors.affiliation: Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, 500 W. 12th Avenue, Columbus, OH, 43210, USA. lee.1339@osu.edu.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Lee
mesh_terms: D000838:Anions / Q000737:chemistry*; D002460:Cell Line; D018014:Gene Transfer Techniques; D006801:Humans; D008055:Lipids / Q000138:chemical synthesis* / Q000737:chemistry; D008081:Liposomes; D035683:MicroRNAs / Q000737:chemistry / Q000235:genetics*; D053758:Nanoparticles
chemical_list: D000838:Anions; D008055:Lipids; D008081:Liposomes; D035683:MicroRNAs
keywords: Anionic lipid; Lipid nanoparticles; Targeted delivery; microRNA delivery