title: Transporters as Drug Targets in Neurological Diseases.
abstract: Membrane transport proteins have central physiological function in maintaining cerebral homeostasis. These transporters are expressed in almost all cerebral cells in which they regulate the movement of a wide range of solutes, including endogenous substrates, xenobiotic, and therapeutic drugs. Altered activity/expression of central nervous system (CNS) transporters has been implicated in the onset and progression of multiple neurological diseases. Neurological diseases are heterogeneous diseases that involve complex pathological alterations with only a few treatment options; therefore, there is a great need for the development of novel therapeutic treatments. To that end, transporters have emerged recently to be promising therapeutic targets to halt or slow the course of neurological diseases. The objective of this review is to discuss implications of transporters in neurological diseases and summarize available evidence for targeting transporters as decent therapeutic approach in the treatment of neurological diseases.
authors.affiliation: Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, Louisiana, USA.
authors.forename: H
authors.initials: H
authors.lastname: Qosa
authors.affiliation: Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, Louisiana, USA.
authors.forename: L A
authors.initials: LA
authors.lastname: Mohamed
authors.affiliation: Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, Louisiana, USA.
authors.forename: S
authors.initials: S
authors.lastname: Alqahtani
authors.affiliation: Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, Louisiana, USA.
authors.forename: B S
authors.initials: BS
authors.lastname: Abuasal
authors.affiliation: Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, Louisiana, USA.
authors.forename: R A
authors.initials: RA
authors.lastname: Hill
authors.affiliation: Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, Louisiana, USA. kaddoumi@ulm.edu.
authors.forename: A
authors.initials: A
authors.lastname: Kaddoumi
mesh_terms: D000818:Animals; D006801:Humans; D026901:Membrane Transport Proteins / Q000187:drug effects* / Q000378:metabolism*; D008959:Models, Neurological; D058990:Molecular Targeted Therapy / Q000379:methods*; D009422:Nervous System Diseases / Q000188:drug therapy* / Q000378:metabolism*
chemical_list: D026901:Membrane Transport Proteins