title: Hair growth promoting activity of cedrol isolated from the leaves of Platycladus orientalis.
abstract: Platycladus orientalis (L.) Franco is traditionally known to potentiate hair growth promotion. However, there has been no report on its main active ingredient responsible for the hair growth activity. In the current work, cedrol as a major constituent from P. orientalis was evaluated for its potential on hair growth in vivo. Different concentrations of cedrol (10, 20 and 30mg/mL) were applied topically over the shaved skin of C57BL/6 mice and monitored for 21days. Results indicated that cedrol significantly promoted hair growth in a dose-dependent manner, particularly for the female mice. Both male and female mice groups treated with 30mg/mL cedrol required shorter time than the blank control and 2% minoxidil groups at different growth stages. Compared with the blank control (8.87mm) and 2% minoxidil (9.94mm) groups at 21days, the hair length of female mice treated with 30mg/mL cedrol showed a remarkable increase with the value of 11.07mm. Hair in male and female mice groups treated with 30mg/mL cedrol was heavier than the 2% minoxidil (38.2 and 35.9mg, respectively) groups with the weight of 42.6 and 45.2mg, respectively. Further observation of the hair follicle demonstrated that cedrol exerted a remarkable effect on the hair follicle length. These findings suggested that cedrol may be the main active ingredient of P. orientalis and have the potential of becoming a new hair growth promoter.
authors.affiliation: School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: National Engineering Research Center for the Pharmaceutics of Traditional Chinese Medicines, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Han
authors.affiliation: School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Chen
authors.affiliation: Liaoning Xinzhong Modern Medicine Co. Ltd., Shenyang, 110041, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Guan
authors.affiliation: School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Fan-Zhi
authors.initials: FZ
authors.lastname: Qu
authors.affiliation: School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China; Key Laboratory of Structure-based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: zyq4885@126.com.
authors.forename: Yu-Qing
authors.initials: YQ
authors.lastname: Zhao
mesh_terms: D000818:Animals; D003460:Crystallization; D029779:Cupressaceae / Q000737:chemistry*; D005260:Female; D006197:Hair / Q000033:anatomy & histology / Q000166:cytology / Q000187:drug effects / Q000254:growth & development*; D008297:Male; D008810:Mice, Inbred C57BL; D009929:Organ Size / Q000187:drug effects; D018515:Plant Leaves / Q000737:chemistry*; D000081223:Polycyclic Sesquiterpenes; D012038:Regeneration / Q000187:drug effects; D013729:Terpenes / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000081223:Polycyclic Sesquiterpenes; D013729:Terpenes; C078669:cedrol
keywords: Cedrol; Hair follicle; Hair growth; Platycladus orientalis