title: Magnetic Field-Induced Accentuation of Drug Release from Core/Shell Magnetic Mesoporous Silica Nanoparticles for Anticancer Treatment.
abstract: Drug (9-aminoacridine) loaded core/shell magnetic iron oxide-containing mesoporous silica nanoparticles (MMSN) were treated with HeLa cells and the drug carriers were agitated by expo- sure to magnetic field. Viability studies show the applicability of drug loaded magnetic material for anticancer treatment, which is enhanced upon stimulation with magnetic field. Confocal micrographs of fluorescein grafted MMSN-treated HeLa cells confirmed the ability of magnetic field to concentrate the synthesized material in the exposed area of the cells. The synthesized material and the applied drug delivery method may find application in magnetic field-responsive targeted treatment of cancer.
authors.lastname: Knezević Nikola Z
mesh_terms: D000585:Aminacrine / Q000008:administration & dosage* / Q000737:chemistry; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D003692:Delayed-Action Preparations / Q000008:administration & dosage* / Q000138:chemical synthesis / Q000528:radiation effects; D004058:Diffusion; D006801:Humans; D060526:Magnetic Fields; D058185:Magnetite Nanoparticles / Q000008:administration & dosage / Q000737:chemistry* / Q000528:radiation effects; D053769:Nanocapsules / Q000008:administration & dosage* / Q000737:chemistry / Q000528:radiation effects; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry* / Q000528:radiation effects
chemical_list: D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D058185:Magnetite Nanoparticles; D053769:Nanocapsules; D012822:Silicon Dioxide; D000585:Aminacrine