title: Enhanced resting-state functional connectivity between core memory-task activation peaks is associated with memory impairment in MCI.
abstract: Resting-state functional connectivity (FC) is altered in Alzheimer's disease (AD) but its predictive value for episodic memory impairment is debated. Here, we aimed to assess whether resting-state FC in core brain regions activated during memory-task functional magnetic resonance imaging is altered and predictive of memory performance in AD and amnestic mild cognitive impairment (aMCI). Twenty-three elderly cognitively healthy controls (HC), 76 aMCI subjects, and 19 AD dementia patients were included. We computed resting-state FC between 18 meta-analytically determined peak coordinates of brain activation during successful memory retrieval. Higher FC between the parahippocampus, parietal cortex, and the middle frontal gyrus was observed in both AD and mild cognitive impairment compared to HC (false-discovery rate-corrected p < 0.05). The increase in FC between the parahippocampus and middle frontal gyrus was associated with reduced episodic memory in aMCI, independent of amyloid-beta positron emission tomography binding and apolipoprotein E ε4-carrier status. In conclusion, increased parahippocampal-prefrontal FC is predictive of impaired episodic memory in aMCI and may reflect a dysfunctional change within the episodic memory-related neural network.
authors.affiliation: Institute for Stroke and Dementia Research, Klinikum der Universität Muenchen, Ludwig-Maximilians-Universität LMU, Munich, Germany; Department of Management Science and Engineering, School of Management, Shanghai University, Shanghai, China. Electronic address: zhangyifei@shu.edu.cn.
authors.forename: Yifei
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Institute for Stroke and Dementia Research, Klinikum der Universität Muenchen, Ludwig-Maximilians-Universität LMU, Munich, Germany.
authors.forename: Lee
authors.initials: L
authors.lastname: Simon-Vermot
authors.affiliation: Institute for Stroke and Dementia Research, Klinikum der Universität Muenchen, Ludwig-Maximilians-Universität LMU, Munich, Germany.
authors.forename: Miguel Á
authors.initials: MÁ
authors.lastname: Araque Caballero
authors.affiliation: Institute for Stroke and Dementia Research, Klinikum der Universität Muenchen, Ludwig-Maximilians-Universität LMU, Munich, Germany.
authors.forename: Benno
authors.initials: B
authors.lastname: Gesierich
authors.affiliation: Institute for Stroke and Dementia Research, Klinikum der Universität Muenchen, Ludwig-Maximilians-Universität LMU, Munich, Germany.
authors.forename: Alexander N W
authors.initials: ANW
authors.lastname: Taylor
authors.affiliation: Institute for Stroke and Dementia Research, Klinikum der Universität Muenchen, Ludwig-Maximilians-Universität LMU, Munich, Germany.
authors.forename: Marco
authors.initials: M
authors.lastname: Duering
authors.affiliation: Institute for Stroke and Dementia Research, Klinikum der Universität Muenchen, Ludwig-Maximilians-Universität LMU, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Dichgans
authors.affiliation: Institute for Stroke and Dementia Research, Klinikum der Universität Muenchen, Ludwig-Maximilians-Universität LMU, Munich, Germany. Electronic address: Michael.Ewers@med.uni-muenchen.de.
authors.forename: Michael
authors.initials: M
authors.lastname: Ewers
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000523:psychology; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology; D003071:Cognition / Q000502:physiology; D060825:Cognitive Dysfunction / Q000000981:diagnostic imaging / Q000523:psychology*; D005260:Female; D059907:Functional Neuroimaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*; D061212:Memory, Episodic; D009415:Nerve Net / Q000000981:diagnostic imaging / Q000503:physiopathology; D011237:Predictive Value of Tests; D012146:Rest / Q000502:physiology*
keywords: Alzheimer's disease; Compensation; Episodic memory; Functional connectivity; Mild cognitive impairment; Network; Resting-state functional MRI