title: To Conquer the Host, Influenza Virus Is Packing It In: Interferon-Antagonistic Strategies beyond NS1.
abstract: The nonstructural protein NS1 is well established as a virulence factor of influenza A virus counteracting induction of the antiviral type I interferon system. Recent studies now show that viral structural proteins, their derivatives, and even the genome itself also contribute to keeping the host defense under control. Here, we summarize the current knowledge on these NS1-independent interferon escape strategies.
authors.affiliation: Laboratory of Molecular Genetics, Institute for Virus Research, Kyoto University, Kyoto, Japan.
authors.forename: Michaela
authors.initials: M
authors.lastname: Weber-Gerlach
authors.affiliation: Institute for Virology, FB10-Veterinary Medicine, Justus Liebig University, Giessen, Germany friedemann.weber@vetmed.uni-giessen.de.
authors.forename: Friedemann
authors.identifier: 0000-0001-9737-337X
authors.initials: F
authors.lastname: Weber
mesh_terms: D054884:Host-Pathogen Interactions; D057131:Immune Evasion; D007372:Interferons / Q000037:antagonists & inhibitors*; D009975:Orthomyxoviridae / Q000276:immunology* / Q000502:physiology*; D017361:Viral Nonstructural Proteins / Q000378:metabolism*; D015678:Viral Structural Proteins / Q000378:metabolism*
chemical_list: C085820:INS1 protein, influenza virus; D017361:Viral Nonstructural Proteins; D015678:Viral Structural Proteins; D007372:Interferons