title: Association between celiac disease and chronic hepatitis C.
abstract: Celiac disease is characterized by a gluten-induced damage of the small bowel in sensitive individuals that may cause malabsorption. Non-intestinal inflammatory diseases may trigger immunologic gluten intolerance in susceptible people and the HCV virus may be considered as a suitable candidate. Interferon therapy could precipitate symptom onset in subjects with silent celiac disease. In fact, symptoms such as diarrhea, anemia, and weight loss may occur during interferon therapy and are associated with serological positivity of anti-tranglutaminase antibodies. To date, considering the available literature data, it is very difficult to support a firm association between HCV chronic hepatitis and celiac disease. Thus, such a serological screening in HCV patients before starting interferon therapy should not be recommended. However, serology for celiac disease must be considered in patients who develop diarrhea and/or weight loss during such therapy.
authors.affiliation: Medical Department, Desio Hospital, Desio (Monza e Brianza), Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Casella
authors.affiliation: Medical Department, Desio Hospital, Desio (Monza e Brianza), Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Viganò
authors.affiliation: Gastroenterology and Hepatology Section, Department of Medicine, University of Perugia Medical School, Perugia, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Romano Settanni
authors.affiliation: Gastroenterology and Hepatology Section, Department of Medicine, University of Perugia Medical School, Perugia, Italy.
authors.forename: Olivia
authors.initials: O
authors.lastname: Morelli
authors.affiliation: Institute of Pathology, Spedali Civili di Brescia, Brescia, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Villanacci
authors.affiliation: Medical Department, Desio Hospital, Desio (Monza e Brianza), Italy.
authors.forename: Vittorio
authors.initials: V
authors.lastname: Baldini
authors.affiliation: Gastroenterology and Hepatology Section, Department of Medicine, University of Perugia Medical School, Perugia, Italy.
authors.forename: Gabrio
authors.initials: G
authors.lastname: Bassotti
keywords: Celiac disease; Chronic hepatitis; HCV virus; Interferon therapy; Liver disease