title: [NEPHROPROTECTIVE PROPERTIES OF 5-HT3 RECEPTOR BLOCKER RU-63 IN EXPERIMENTAL ACUTE RENAL FAILURE UNDER HYPERGRAVITY CONDITIONS].
abstract: The effective diuretic dose of 5-HT3 receptor blocker RU-63 (1 mg/kg) was found in experiments on white rats. It is established that the diuretic and saluretic effects of compound RU-63 increase on the background of impact of the gravitational factor. Compound RU-63 (1 mg/kg, subcutaneously) administered daily under hypergravity conditions (3 g in the direction of centrifugal force toward the kidneys) in animals with model ischemic acute renal failure increased excretory function of kidneys, glomerular filtration rate, and creatininuresis (on average by 180%; p < 0.05), and decreased serum creatinine, urinary excretion of protein, lactate dehydrogenase, and g-glutamyl transferase (on average by 49%; p < 0.05) as compared to the untreated control. Under similar conditions, the diuretic hydrochlorothiazide (in a dose of 20 mg/kg, intragastric) produced a more pronounced creatininuretic action than that of RU-63 (by 358%; p < 0.05).
authors.forename: E N
authors.initials: EN
authors.lastname: Zaitseva
authors.forename: A V
authors.initials: AV
authors.lastname: Dubishchev
authors.forename: D S
authors.initials: DS
authors.lastname: Yakovlev
authors.forename: V A
authors.initials: VA
authors.lastname: Anisimova
mesh_terms: D058186:Acute Kidney Injury / Q000188:drug therapy* / Q000503:physiopathology / Q000652:urine; D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology*; D003404:Creatinine / Q000652:urine; D004232:Diuretics / Q000494:pharmacology*; D005919:Glomerular Filtration Rate; D006852:Hydrochlorothiazide / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology; D007770:L-Lactate Dehydrogenase / Q000652:urine; D011188:Potassium / Q000652:urine; D020011:Protective Agents / Q000494:pharmacology*; D011507:Proteinuria / Q000188:drug therapy* / Q000503:physiopathology / Q000652:urine; D051381:Rats; D044406:Receptors, Serotonin, 5-HT3 / Q000378:metabolism; D058831:Serotonin 5-HT3 Receptor Antagonists / Q000494:pharmacology*; D012964:Sodium / Q000652:urine; D005723:gamma-Glutamyltransferase / Q000652:urine
chemical_list: D001562:Benzimidazoles; D004232:Diuretics; D020011:Protective Agents; D044406:Receptors, Serotonin, 5-HT3; D058831:Serotonin 5-HT3 Receptor Antagonists; D006852:Hydrochlorothiazide; D012964:Sodium; D003404:Creatinine; D007770:L-Lactate Dehydrogenase; D005723:gamma-Glutamyltransferase; D011188:Potassium