title: PI(4,5)P2 and L-type Ca(2+) Channels Partner Up to Fine-Tune Ca(2+) Dynamics in β Cells.
abstract: The PI(4,5)P2 level in the plasma membrane is dynamically regulated by cytoplasmic ATP production and receptor-mediated transmembrane signaling cascades. In this issue of Cell Chemical Biology, Xie et al. (2016) use optogenetics to micro-manipulate membrane PI(4,5)P2 and reveal how acute PI(4,5)P2 changes can alter intracellular Ca(2+) dynamics and insulin secretion in pancreatic β cells.
authors.affiliation: Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Korea. Electronic address: bcsuh@dgist.ac.kr.
authors.forename: Byung-Chang
authors.initials: BC
authors.lastname: Suh
authors.affiliation: Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Korea.
authors.forename: Jun-Hee
authors.initials: JH
authors.lastname: Yeon
authors.affiliation: Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Korea.
authors.forename: Cheon-Gyu
authors.initials: CG
authors.lastname: Park
mesh_terms: D002462:Cell Membrane; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells; D010716:Phosphatidylinositols; D015398:Signal Transduction
chemical_list: D010716:Phosphatidylinositols