title: The Twin Study of Negative Valence Emotional Constructs.
abstract: The Twin Study of Negative Valence Emotional Constructs is a multi-site study designed to examine the relationship between a broad selection of potential measures designed to assess putative endophenotypes for negative valence systems (NVS) and early symptoms of internalizing disorders (IDs). In this article, we describe the sample characteristics, data collection protocols, and measures used. Pre-adolescent Caucasian twin pairs were recruited through the Mid-Atlantic Twin Registry; data collection began in February of 2013. Enrolled twins completed various dimensional self-report measures along with cognitive, emotional, and psychophysiological tasks designed to assess NVS function. Parents also completed surveys about their twins and themselves. In addition, a subset of the twins also participated in a neuroimaging protocols. Data collection is in the final stages, and preliminary analyses are underway. The findings will potentially expand our understanding of the mechanisms by which genetic and environmental factors contribute to individual differences in NVS phenotypes and provide new insights into underlying risk factors for IDs.
authors.affiliation: Virginia Institute for Psychiatric and Behavioral Genetics and Department of Psychiatry,Virginia Commonwealth University,Richmond,Virginia,USA.
authors.forename: Dever M
authors.initials: DM
authors.lastname: Carney
authors.affiliation: Emotion and Development Branch,National Institute of Mental Health,National Institutes of Health,Department of Health and Human Services,Bethesda,Maryland,USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Moroney
authors.affiliation: Emotion and Development Branch,National Institute of Mental Health,National Institutes of Health,Department of Health and Human Services,Bethesda,Maryland,USA.
authors.forename: Laura
authors.initials: L
authors.lastname: Machlin
authors.affiliation: Virginia Institute for Psychiatric and Behavioral Genetics and Department of Psychiatry,Virginia Commonwealth University,Richmond,Virginia,USA.
authors.forename: Shannon
authors.initials: S
authors.lastname: Hahn
authors.affiliation: Virginia Institute for Psychiatric and Behavioral Genetics and Department of Psychiatry,Virginia Commonwealth University,Richmond,Virginia,USA.
authors.forename: Jeanne E
authors.initials: JE
authors.lastname: Savage
authors.affiliation: Virginia Institute for Psychiatric and Behavioral Genetics and Department of Psychiatry,Virginia Commonwealth University,Richmond,Virginia,USA.
authors.forename: Minyoung
authors.initials: M
authors.lastname: Lee
authors.affiliation: Emotion and Development Branch,National Institute of Mental Health,National Institutes of Health,Department of Health and Human Services,Bethesda,Maryland,USA.
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Towbin
authors.affiliation: Emotion and Development Branch,National Institute of Mental Health,National Institutes of Health,Department of Health and Human Services,Bethesda,Maryland,USA.
authors.forename: Melissa A
authors.initials: MA
authors.lastname: Brotman
authors.affiliation: Emotion and Development Branch,National Institute of Mental Health,National Institutes of Health,Department of Health and Human Services,Bethesda,Maryland,USA.
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Pine
authors.affiliation: Emotion and Development Branch,National Institute of Mental Health,National Institutes of Health,Department of Health and Human Services,Bethesda,Maryland,USA.
authors.forename: Ellen
authors.initials: E
authors.lastname: Leibenluft
authors.affiliation: Virginia Institute for Psychiatric and Behavioral Genetics and Department of Psychiatry,Virginia Commonwealth University,Richmond,Virginia,USA.
authors.forename: Roxann
authors.initials: R
authors.lastname: Roberson-Nay
authors.affiliation: Virginia Institute for Psychiatric and Behavioral Genetics and Department of Psychiatry,Virginia Commonwealth University,Richmond,Virginia,USA.
authors.forename: John M
authors.initials: JM
authors.lastname: Hettema
mesh_terms: D000293:Adolescent; D001008:Anxiety Disorders / Q000000981:diagnostic imaging / Q000235:genetics / Q000523:psychology; D002648:Child; D004644:Emotions; D005260:Female; D006801:Humans; D008297:Male; D012042:Registries; D014427:Twins / Q000235:genetics*
keywords: anxiety; internalizing; negative valence; twin study