title: Use of plasma exchange or double filtration plasmapheresis to reduce body burden of polychlorinated biphenyls: A pilot trial.
abstract: The aim of the study was to examine whether plasma exchange (PE) or selective double filtration plasmapheresis (DFPP) is able to reduce the internal Polychlorinated biphenyl (PCB) burden of highly exposed participants of the health effects in high-level exposure to PCB (HELPcB) cohort. HELPcB is a surveillance program for former PCB-exposed workers of a German capacitor recycling company. After comparative evaluation of PE and DFPP in a phase I, DFPP was chosen as method for further treatment. In phase II, five participants underwent DFPP at weekly intervals for the duration of 12 weeks. Six PCB species were selected as indicators and were analyzed in the plasma before and after each treatment and 4 weeks after the last treatment. The PCB levels before and after each DFPP treatment showed a significant reduction in PCB blood levels; however, there was no significant change in PCB levels within the samples collected before each treatment as compared with the samples collected in the following week before treatment. Even the difference between PCB levels at the onset of the study and 4 weeks after the last treatment was not significant. The results of this pilot trial do not encourage further investigations in using therapeutic apheresis to reduce the PCB body burden.
authors.affiliation: Institute for Occupational Medicine and Social Medicine, RWTH Aachen University, Pauwelsstrasse 30, Aachen 52074, Germany.
authors.forename: Monika
authors.initials: M
authors.lastname: Gube
authors.affiliation: Institute for Occupational Medicine and Social Medicine, RWTH Aachen University, Pauwelsstrasse 30, Aachen 52074, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Schettgen
authors.affiliation: Institute for Occupational Medicine and Social Medicine, RWTH Aachen University, Pauwelsstrasse 30, Aachen 52074, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Kraus
authors.affiliation: Institute for Occupational Medicine and Social Medicine, RWTH Aachen University, Pauwelsstrasse 30, Aachen 52074, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Schikowsky
authors.affiliation: Apheresis Research Institute, Stadtwaldguertel 77, Cologne 50935, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Heibges
authors.affiliation: Apheresis Research Institute, Stadtwaldguertel 77, Cologne 50935, Germany.
authors.forename: Reinhard
authors.initials: R
authors.lastname: Klingel
authors.affiliation: Outpatient Center for Dialysis 'Dialyse am Hellweg', Stefanstr. 2, Dortmund 44135, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Hoffmann
authors.affiliation: Outpatient Center for Dialysis 'Dialyse am Hellweg', Stefanstr. 2, Dortmund 44135, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Wiemeyer
authors.affiliation: Outpatient Center for Dialysis 'Dialyse am Hellweg', Stefanstr. 2, Dortmund 44135, Germany.
authors.forename: Jewgeni
authors.initials: J
authors.lastname: Jacobson
authors.affiliation: Institute for Occupational Medicine and Social Medicine, RWTH Aachen University, Pauwelsstrasse 30, Aachen 52074, Germany.
authors.forename: André
authors.initials: A
authors.lastname: Esser
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001822:Body Burden; D015331:Cohort Studies; D004784:Environmental Monitoring / Q000379:methods; D005858:Germany; D006801:Humans; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000032:analysis*; D010865:Pilot Projects; D010951:Plasma Exchange; D010956:Plasmapheresis; D011078:Polychlorinated Biphenyls / Q000032:analysis / Q000097:blood*; D059027:Recycling; D016896:Treatment Outcome
chemical_list: D011078:Polychlorinated Biphenyls