title: Overexpression of TP53 is associated with poor survival, but not with reduced response to hypomethylating agents in older patients with acute myeloid leukaemia.
authors.affiliation: Department of Haematology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
authors.forename: Lieke H
authors.initials: LH
authors.lastname: van der Helm
authors.affiliation: Department of Haematology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
authors.forename: Gerbrig
authors.initials: G
authors.lastname: Berger
authors.affiliation: Department of Pathology and Medical Biology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
authors.forename: Arjan
authors.initials: A
authors.lastname: Diepstra
authors.affiliation: Department of Haematology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
authors.forename: Gerwin
authors.initials: G
authors.lastname: Huls
authors.affiliation: Department of Haematology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
authors.forename: Edo
authors.initials: E
authors.lastname: Vellenga
mesh_terms: D000367:Age Factors; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology; D019175:DNA Methylation / Q000187:drug effects*; D015870:Gene Expression; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics* / Q000401:mortality*; D009154:Mutation; D011379:Prognosis; D016019:Survival Analysis; D016896:Treatment Outcome; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D016159:Tumor Suppressor Protein p53
keywords: TP53 mutation; acute myeloid leukaemia; hypomethylating agents; older age; treatment