title: In vitro-Scientific evaluation on antimicrobial, antioxidant, cytotoxic properties and phytochemical constituents of traditional coastal medicinal plants.
abstract: In the present study, evaluation of antimicrobial, antioxidant, phytochemical constituents and toxicological properties of six coastal medicinal plants (CMP's) such as Ipomea biloba, Cantharanthus roseus, Cymbopogon citratus, Vitex negundo, Thespesia populnea and Pandanus tectorius was done. The maximum antimicrobial activity was recorded by methanolic extracts of V. negundo and T. populnea against bacterial and fungal pathogens. Similarly, methanolic extracts of V. negundo and T. populnea evidenced highest antioxidant properties. The extract of T. populnea showed the maximum cytotoxicity against Artemia salina with the LC50value of 478.11μg/ml. The hemolytic property of CMP's extracts was V. negundo (8.91%), T. populnea (21%) and C. citratus (64%) also the hemolytic index did not show any hemolysis of human erythrocytes. Furthermore, the TLC separation of V. negundo and T. populnea extracts exhibited the presence of Flavonoids (Rf-0.74) and Terpenoids (Rf-0.64). The present findings propose the promising clinical applications of selected CMP's.
authors.affiliation: Department of Biotechnology, Sri Kalishwari College (Autonomous), Sivakasi, Virudhunagar, 626 123, Virudhunagar District, Tamilnadu, India; Research Institute, SRM University, Kattankulathur, 603 203, Kancheepuram District, Tamilnadu, India. Electronic address: algaprakash@gmail.com.
authors.forename: Santhiyagu
authors.initials: S
authors.lastname: Prakash
authors.affiliation: Centre for Marine Science and Technology, Manonmaniam Sundaranar University, Rajakkamangalam, 629 502, Kanyakumari District, Tamilnadu, India.
authors.forename: Ramasamy
authors.initials: R
authors.lastname: Ramasubburayan
authors.affiliation: Department of Environmental Biotechnology, School of Environmental Sciences, Bharathidasan University, Tiruchirappalli, 620 024, Tamilnadu, India.
authors.forename: Vijayan Sri
authors.initials: VS
authors.lastname: Ramkumar
authors.affiliation: Department of Animal Health Management, Science Campus, Alagappa University, Karaikudi, 630 004, Tamilnadu, India.
authors.forename: Ethiraj
authors.initials: E
authors.lastname: Kannapiran
authors.affiliation: Department of Animal Science, Manonmaniam Sundaranar University, Abishekapatti - 627 012, Tirunelveli District, Tamilnadu, India.
authors.forename: Arunachalam
authors.initials: A
authors.lastname: Palavesam
authors.affiliation: Centre for Marine Science and Technology, Manonmaniam Sundaranar University, Rajakkamangalam, 629 502, Kanyakumari District, Tamilnadu, India.
authors.forename: Grasian
authors.initials: G
authors.lastname: Immanuel
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001156:Artemia / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects; D016923:Cell Death / Q000187:drug effects; D002855:Chromatography, Thin Layer; D045424:Complex Mixtures / Q000494:pharmacology; D017753:Ecosystem; D016166:Free Radical Scavengers / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D008519:Medicine, Traditional; D000432:Methanol / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D064209:Phytochemicals / Q000494:pharmacology*; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D018675:Toxicity Tests
chemical_list: D000890:Anti-Infective Agents; D000975:Antioxidants; D045424:Complex Mixtures; D016166:Free Radical Scavengers; D064209:Phytochemicals; D010936:Plant Extracts; D000432:Methanol
keywords: Antimicrobials; Antioxidants; CMP’s; Hemolytic properties