title: Soft tissue Rosai-Dorfman disease in child: A case report and literature review.
abstract: BACKGROUND
  Rosai-Dorfman disease was commonly characterized as massive, painless, bilateral, symmetric cervical lymphadenopathy, with fever, leukocytosis, and elevated sedimentation rate. However, soft tissue Rosai-Dorfman disease (STRDD) is a rare benign tumor.
  
  
  METHODS
  We hereby present 1 case of a 17-month-old girl, an isolated subcutaneous mass was detected on her right forearm, and no signs of pain, swelling, or erythema were observed at the site.
  
  
  RESULTS
  The patient underwent an excisional biopsy for the mass. Immunohistochemistry results showed that it was positive for S-100 protein and CD68, whereas negative for CD1a, which supported the diagnosis of STRDD.
  
  
  CONCLUSIONS
  The patient showed no evidence of recurrence or metastasis 2 years after the surgery.Some multifocal masses were reported to be much more prone to recurrence. Further follow-up of STRDD is necessary.
authors.affiliation: Department of Pediatric Orthopedics Department of Pathology, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai Department of Pediatric Orthopedics, Chengdu Women's and Children's Center Hospital, Chengdu, Sichuan Province, China.
authors.forename: Yunlan
authors.initials: Y
authors.lastname: Xu
authors.forename: Bingqiang
authors.initials: B
authors.lastname: Han
authors.forename: Jie
authors.initials: J
authors.lastname: Yang
authors.forename: Jing
authors.initials: J
authors.lastname: Ma
authors.forename: Ji
authors.initials: J
authors.lastname: Chen
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Wang
mesh_terms: D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D005542:Forearm; D015618:Histiocytosis, Sinus / Q000175:diagnosis* / Q000601:surgery*; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant