title: Endogenous Endophthalmitis in the American and Korean Population: An 8-year Retrospective Study.
abstract: OBJECTIVE
  To study the clinical features of endogenous endophthalmitis (EE) in sample patient populations from the USA and South Korea over an 8-year period.
  
  
  METHODS
  We reviewed data from 128 eyes of 60 American and 48 Korean patients diagnosed with EE and compared their clinical characteristics.
  
  
  RESULTS
  Fungemia and liver abscess were the most common extraocular infection sources among American (26.7%) and Korean patients (33.3%), respectively. Klebsiella pneumoniae and Candida species were the most common pathogens of EE in the Korean and the American patients, respectively. Endophthalmitis caused by fungi had a better visual prognosis than that caused by bacteria (p = 0.001). Vitrectomy was beneficial for eyes with EE due to virulent bacteria presenting with worse than counting finger vision.
  
  
  CONCLUSIONS
  The predisposing conditions and responsible organisms for EE vary in different regions of the world. The visual prognosis was strongly influenced by the underlying pathogen.
authors.affiliation: a Department of Ophthalmology, Massachusetts Eye and Ear Infirmary , Harvard Medical School , Boston , Massachusetts , USA.|b Department of Ophthalmology , Hanyang University Medical College , Seoul , Republic of Korea.
authors.forename: Heeyoon
authors.initials: H
authors.lastname: Cho
authors.affiliation: b Department of Ophthalmology , Hanyang University Medical College , Seoul , Republic of Korea.
authors.forename: Yong Un
authors.initials: YU
authors.lastname: Shin
authors.affiliation: c Department of Ophthalmology , Boston University School of Medicine , Boston , Massachusetts , USA.
authors.forename: Nicole H
authors.initials: NH
authors.lastname: Siegel
authors.affiliation: d Department of Ophthalmology , Seoul National University College of Medicine , Seoul , Republic of Korea.
authors.forename: Hyeong Gon
authors.identifier: http://orcid.org/0000-0002-1795-202X
authors.initials: HG
authors.lastname: Yu
authors.affiliation: a Department of Ophthalmology, Massachusetts Eye and Ear Infirmary , Harvard Medical School , Boston , Massachusetts , USA.
authors.forename: Lucia
authors.initials: L
authors.lastname: Sobrin
authors.affiliation: c Department of Ophthalmology , Boston University School of Medicine , Boston , Massachusetts , USA.
authors.forename: Achal
authors.initials: A
authors.lastname: Patel
authors.affiliation: a Department of Ophthalmology, Massachusetts Eye and Ear Infirmary , Harvard Medical School , Boston , Massachusetts , USA.|e Infectious Disease Unit, Department of Medicine , Massachusetts General Hospital, Harvard Medical School , Boston , Massachusetts , USA.
authors.forename: Marlene L
authors.initials: ML
authors.lastname: Durand
authors.affiliation: a Department of Ophthalmology, Massachusetts Eye and Ear Infirmary , Harvard Medical School , Boston , Massachusetts , USA.
authors.forename: Joan W
authors.initials: JW
authors.lastname: Miller
authors.affiliation: a Department of Ophthalmology, Massachusetts Eye and Ear Infirmary , Harvard Medical School , Boston , Massachusetts , USA.
authors.forename: Deeba
authors.initials: D
authors.lastname: Husain
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001419:Bacteria / Q000302:isolation & purification*; D009877:Endophthalmitis / Q000453:epidemiology* / Q000382:microbiology / Q000601:surgery; D015818:Eye Infections, Bacterial / Q000453:epidemiology* / Q000382:microbiology / Q000601:surgery; D015821:Eye Infections, Fungal / Q000453:epidemiology* / Q000382:microbiology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D005658:Fungi / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D014481:United States / Q000453:epidemiology; D014821:Vitrectomy; D014822:Vitreous Body / Q000382:microbiology*; D055815:Young Adult
keywords: Endogenous; endophthalmitis; infectious; vitrectomy