title: Proteomics and molecular tools for unveiling missing links in the biochemical understanding of schizophrenia.
abstract: Psychiatric disorders are one of the biggest burdens to society, with significant personal and economical costs. Schizophrenia (SCZ), among them, is still poorly understood, and its molecular characterization is crucial to improve patients' diagnosis and treatment. The combination of genetic, biochemical, and environmental factors leads to systemic alterations, which are yet to be fully comprehended. Thus, understanding those missing links by connecting some molecular reports of SCZ is essential. From postmortem brain to animal models and cell culture, new tools are emerging, including recent advances in proteomics, and there is a need to apply them to solve these problems. Here, we review some of those features, mainly related to where proteomics could help, and discuss whether those new technologies could and should be applied to psychiatric disorder studies.
authors.affiliation: Department of Biochemistry and Tissue Biology, Laboratory of Neuroproteomics, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
authors.forename: Juliana M
authors.initials: JM
authors.lastname: Nascimento
authors.affiliation: Department of Biochemistry and Tissue Biology, Laboratory of Neuroproteomics, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
authors.forename: Sheila
authors.initials: S
authors.lastname: Garcia
authors.affiliation: Department of Biochemistry and Tissue Biology, Laboratory of Neuroproteomics, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
authors.forename: Verônica M
authors.initials: VM
authors.lastname: Saia-Cereda
authors.affiliation: Department of Biochemistry and Tissue Biology, Laboratory of Neuroproteomics, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
authors.forename: Aline G
authors.initials: AG
authors.lastname: Santana
authors.affiliation: Department of Biochemistry and Tissue Biology, Laboratory of Neuroproteomics, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
authors.forename: Caroline
authors.initials: C
authors.lastname: Brandao-Teles
authors.affiliation: Department of Biochemistry and Tissue Biology, Laboratory of Neuroproteomics, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
authors.forename: Giuliana S
authors.initials: GS
authors.lastname: Zuccoli
authors.affiliation: Department of Biochemistry and Tissue Biology, Laboratory of Neuroproteomics, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
authors.forename: Danielle G
authors.initials: DG
authors.lastname: Junqueira
authors.affiliation: Department of Biochemistry and Tissue Biology, Laboratory of Neuroproteomics, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
authors.forename: Guilherme
authors.initials: G
authors.lastname: Reis-de-Oliveira
authors.affiliation: Department of Biochemistry and Tissue Biology, Laboratory of Neuroproteomics, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
authors.forename: Paulo A
authors.initials: PA
authors.lastname: Baldasso
authors.affiliation: Department of Biochemistry and Tissue Biology, Laboratory of Neuroproteomics, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
authors.forename: Juliana S
authors.initials: JS
authors.lastname: Cassoli
authors.affiliation: Department of Biochemistry and Tissue Biology, Laboratory of Neuroproteomics, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
authors.forename: Daniel
authors.initials: D
authors.lastname: Martins-de-Souza
mesh_terms: D000818:Animals; D055354:Exosomes / Q000378:metabolism; D000072669:Gene Editing; D006801:Humans; D040901:Proteomics / Q000379:methods*; D012559:Schizophrenia / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D013234:Stem Cells / Q000378:metabolism
keywords: Biomarkers; CRISPR; MS; SRM; Schizophrenia; iPSCs