title: Oxygen Delivering Biomaterials for Tissue Engineering.
abstract: Tissue engineering (TE) has provided promising strategies for regenerating tissue defects, but few TE approaches have been translated for clinical applications. One major barrier in TE is providing adequate oxygen supply to implanted tissue scaffolds, since oxygen diffusion from surrounding vasculaturein vivois limited to the periphery of the scaffolds. Moreover, oxygen is also an important signaling molecule for controlling stem cell differentiation within TE scaffolds. Various technologies have been developed to increase oxygen deliveryin vivoand enhance the effectiveness of TE strategies. Such technologies include hyperbaric oxygen therapy, perfluorocarbon- and hemoglobin-based oxygen carriers, and oxygen-generating, peroxide-based materials. Here, we provide an overview of the underlying mechanisms and how these technologies have been utilized forin vivoTE applications. Emerging technologies and future prospects for oxygen delivery in TE are also discussed to evaluate the progress of this field towards clinical translation.
authors.affiliation: Translational TE Center, Johns Hopkins University School of Medicine, Baltimore MD 21287, USA; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore MD, 21205 USA.
authors.forename: Ashley L
authors.initials: AL
authors.lastname: Farris
authors.affiliation: Translational TE Center, Johns Hopkins University School of Medicine, Baltimore MD 21287, USA; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore MD, 21205 USA.
authors.forename: Alexandra N
authors.initials: AN
authors.lastname: Rindone
authors.affiliation: Translational TE Center, Johns Hopkins University School of Medicine, Baltimore MD 21287, USA; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore MD, 21205 USA; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore MD 21218, USA; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218, USA.
authors.forename: Warren L
authors.initials: WL
authors.lastname: Grayson