title: Salivary and hair glucocorticoids and sleep in very preterm children during school age.
abstract: Very preterm birth involves increased stress for the child, which may lead to programming of the hypothalamic-pituitary-adrenal (HPA) axis activity and poor sleep in later life. Moreover, there is evidence for a relationship between HPA axis activity and sleep. However, research with objective sleep measures in very preterm children during school-age is rare. Eighty-five healthy children born very preterm (<32nd gestational week) and 91 full-term children aged 7-12 years were recruited for the present study. To assess HPA axis activity, salivary cortisol was measured at awakening, 10, 20, and 30min later. In addition, hair cortisol and cortisone concentrations were quantified using liquid chromatography tandem mass spectrometry to assess cumulative endocrine activity over the preceding months. One night of in-home polysomnographic sleep assessment was conducted to assess sleep duration, sleep continuity, and sleep architecture. Children born very preterm showed significantly lower levels of cortisol at awakening and lower overall post-awakening cortisol secretion, lower cortisone in hair, and earlier sleep onset than full-term children. Across the whole sample, overall post-awakening cortisol secretion was positively related to sleep onset time and negatively to sleep duration. The association between prematurity status and post-awakening cortisol secretion was partially mediated by earlier sleep onset time. In conclusion, this study provides evidence for a possible down-regulation of the HPA axis activity and slightly earlier sleep phase in very preterm children during school age.
authors.affiliation: University of Basel, Department of Psychology, Basel, Switzerland.
authors.forename: Natalie
authors.initials: N
authors.lastname: Maurer
authors.affiliation: University of Basel, Department of Psychology, Basel, Switzerland.
authors.forename: Nadine
authors.initials: N
authors.lastname: Perkinson-Gloor
authors.affiliation: Technische Universität Dresden, Department of Psychology, Dresden, Germany.
authors.forename: Tobias
authors.initials: T
authors.lastname: Stalder
authors.affiliation: University of Basel, Department of Psychology, Basel, Switzerland.
authors.forename: Priska
authors.initials: P
authors.lastname: Hagmann-von Arx
authors.affiliation: Psychiatric Clinics of the University of Basel, Center for Affective, Stress, and Sleep Disorders, Basel, Switzerland; University of Basel, Faculty of Medicine, Department of Sport, Exercise and Health, Division Sport and Psychosocial Health, Basel, Switzerland.
authors.forename: Serge
authors.initials: S
authors.lastname: Brand
authors.affiliation: Psychiatric Clinics of the University of Basel, Center for Affective, Stress, and Sleep Disorders, Basel, Switzerland.
authors.forename: Edith
authors.initials: E
authors.lastname: Holsboer-Trachsler
authors.affiliation: University Children's Hospital Basel, Fetal and Neonatal Stress Research Group, Basel, Switzerland.
authors.forename: Sven
authors.initials: S
authors.lastname: Wellmann
authors.affiliation: University of Basel, Department of Psychology, Basel, Switzerland.
authors.forename: Alexander
authors.initials: A
authors.lastname: Grob
authors.affiliation: University Children's Hospital Basel, Division of Neuropediatrics and Developmental Medicine, Basel, Switzerland.
authors.forename: Peter
authors.initials: P
authors.lastname: Weber
authors.affiliation: University of Warwick, Department of Psychology, University Road, Coventry CV4 7AL, United Kingdom. Electronic address: s.lemola@warwick.ac.uk.
authors.forename: Sakari
authors.initials: S
authors.lastname: Lemola
mesh_terms: D002648:Child; D003348:Cortisone / Q000378:metabolism*; D005260:Female; D006197:Hair / Q000737:chemistry; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism / Q000503:physiopathology*; D062071:Infant, Extremely Premature; D008297:Male; D010913:Pituitary-Adrenal System / Q000378:metabolism / Q000503:physiopathology*; D012463:Saliva / Q000737:chemistry; D012890:Sleep / Q000502:physiology*
chemical_list: D003348:Cortisone; D006854:Hydrocortisone
keywords: Cortisol; Glucocorticoids; HPA axis activity; Preterm birth; Sleep architecture; Sleep electroencephalography