title: Ca(OH)2-Catalyzed Condensation of Aldehydes with Methyl ketones in Dilute Aqueous Ethanol: A Comprehensive Access to α,β-Unsaturated Ketones.
abstract: Cheap, abundant but seldom-employed Ca(OH)2 was found to be an excellent low-loading (5-10 mol%) catalyst for Claisen-Schmidt condensation of aldehydes with methyl ketones under mild conditions. It was interesting that dilute aqueous ethanol (20 v/v%) was unexpectedly discovered to be the optimal solvent. The reaction was scalable at least to 100 mmol and calcium could be precipitated by CO2 and removed by filtration. Evaporation of solvent directly afforded the product in the excellent 96% yield with high purity, as confirmed by its (1)H NMR spectrum.
authors.affiliation: Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002 China.
authors.forename: Lei
authors.initials: L
authors.lastname: Yu
authors.affiliation: Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002 China.
authors.forename: Mengting
authors.initials: M
authors.lastname: Han
authors.affiliation: Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002 China.
authors.forename: Jie
authors.initials: J
authors.lastname: Luan
authors.affiliation: Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002 China.|Jiangsu Yangnong Chemical Group Co. Ltd., Yangzhou, Jiangsu, 225009, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Xu
authors.affiliation: Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002 China.
authors.forename: Yuanhua
authors.initials: Y
authors.lastname: Ding
authors.affiliation: Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002 China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Xu