title: Preparation and characterization of alginate/silver/nicotinamide nanocomposites for treating diabetic wounds.
abstract: Silver/Alginate/Nicotinamide nanoparticles composite (Ag/ALG/Nic) was prepared and used for the first time to fabricate wound dressing material. Sodium alginate (ALG) was used as reducing and stabilizing agents for preparation of silver nanoparticles (Ag-NPs). Effect of concentrations of alginate (ALG) on the particle size of silver were studied and confirmed by different techniques like UV/vis spectroscopy, transmission electron microscope (TEM) and dynamic light scattering (DLS). Nonwoven viscous fabrics were used as a carrier for silver/alginate/nanoparticles composite by impregnated the nonwoven fabrics as per the padding-curing technique. Nicotinamide (Nic) as anti-inflammatory drug was entrapped into Ag-NPS/ALG/nonwoven fabrics. Scanning electron microscope and energy dispersive x-ray (SEM-EDX) were used to evaluate the presence of Ag/ALG/Nic nanoparticles composite anchored the nonwoven fabrics. The antibacterial activity of the Ag/ALG/Nic wound dressing material was evaluated against Escherichia coli (E. coli) and Staphylococcus Aureus (St. Aureus). The wound healing and histological studied were evaluated by using burn diabetic rat animals.
authors.affiliation: National Research Centre, Textile Research Division, Department of Pre-treatment and Finishing of Cellulosic Fibers, Dokki, Cairo, Egypt.
authors.forename: A S
authors.initials: AS
authors.lastname: Montaser
authors.affiliation: National Research Centre, Textile Research Division, Department of Pre-treatment and Finishing of Cellulosic Fibers, Dokki, Cairo, Egypt; CEITEC-Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic; SCITEG, a.s., Brno, Czech Republic. Electronic address: abdo_mohsennrc@yahoo.com.
authors.forename: A M
authors.initials: AM
authors.lastname: Abdel-Mohsen
authors.affiliation: National Research Centre, Textile Research Division, Department of Pre-treatment and Finishing of Cellulosic Fibers, Dokki, Cairo, Egypt.
authors.forename: M A
authors.initials: MA
authors.lastname: Ramadan
authors.affiliation: National Research Centre, Pathology Department, Dokki, Cairo, Egypt.
authors.forename: A A
authors.initials: AA
authors.lastname: Sleem
authors.affiliation: National Research Centre, Pharmacology Department, Dokki, Cairo, Egypt.
authors.forename: N M
authors.initials: NM
authors.lastname: Sahffie
authors.affiliation: CEITEC-Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic; SCITEG, a.s., Brno, Czech Republic; Faculty of Chemistry, Institute of Materials Chemistry, Brno University of Technology, Brno, Czech Republic.
authors.forename: J
authors.initials: J
authors.lastname: Jancar
authors.affiliation: National Research Centre, Textile Research Division, Department of Pre-treatment and Finishing of Cellulosic Fibers, Dokki, Cairo, Egypt.
authors.forename: A
authors.initials: A
authors.lastname: Hebeish
mesh_terms: D000279:Administration, Cutaneous; D000464:Alginates / Q000737:chemistry*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001458:Bandages; D002056:Burns / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000150:complications / Q000188:drug therapy / Q000382:microbiology; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D004927:Escherichia coli Infections / Q000150:complications / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D053761:Nanocomposites / Q000737:chemistry / Q000648:ultrastructure; D009536:Niacinamide / Q000494:pharmacology*; D010316:Particle Size; D011817:Rabbits; D051381:Rats; D012834:Silver / Q000737:chemistry*; D012867:Skin / Q000187:drug effects / Q000382:microbiology / Q000473:pathology; D013203:Staphylococcal Infections / Q000150:complications / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013311:Streptozocin; D013784:Textiles
chemical_list: D000464:Alginates; D000894:Anti-Inflammatory Agents, Non-Steroidal; D006603:Hexuronic Acids; D009536:Niacinamide; D012834:Silver; D013311:Streptozocin; D020723:Glucuronic Acid
keywords: Nanocomposite; Nonwoven fabrics; Wound dressing