title: Mechanistic insights into the potassium tert-butoxide-mediated synthesis of N-heterobiaryls.
abstract: We report herein that symmetrical and non-symmetrical N-heterobiaryls are produced by a potassium tert-butoxide-mediated dimerization of heterocyclic N-oxides. The reaction is scalable and transition metal-free, and can be carried out under thermal and microwave conditions. Preliminary mechanistic studies point to the involvement of radical anionic intermediates arising from the N-oxide substrates and potassium tert-butoxide.
authors.affiliation: Department of Chemistry, The University of Texas at San Antonio, San Antonio, TX 78249, USA. oleg.larionov@utsa.edu.
authors.forename: David E
authors.initials: DE
authors.lastname: Stephens
authors.affiliation: Department of Chemistry, The University of Texas at San Antonio, San Antonio, TX 78249, USA. oleg.larionov@utsa.edu and Centre for Biodiversity and Drug Discovery, Institute for Scientific Research and High Technology Services (INDICASAT-AIP), City of Knowledge, Panama City, Republic of Panama and Department of Biotechnology, Acharya Nagarjuna University, Nagarjuna Nagar, India.
authors.forename: Johant
authors.initials: J
authors.lastname: Lakey-Beitia
authors.affiliation: Department of Chemistry, The University of Texas at San Antonio, San Antonio, TX 78249, USA. oleg.larionov@utsa.edu.
authors.forename: Jessica E
authors.initials: JE
authors.lastname: Burch
authors.affiliation: Department of Chemistry, The University of Texas at San Antonio, San Antonio, TX 78249, USA. oleg.larionov@utsa.edu.
authors.forename: Hadi D
authors.initials: HD
authors.lastname: Arman
authors.affiliation: Department of Chemistry, The University of Texas at San Antonio, San Antonio, TX 78249, USA. oleg.larionov@utsa.edu.
authors.forename: Oleg V
authors.initials: OV
authors.lastname: Larionov