title: Valvular Cytomegalovirus Endocarditis.
abstract: Endocarditis is a rare presentation for cytomegalovirus (CMV) infection. We present the case of a 49-year-old man who underwent mitral and tricuspid valve replacement for valvular CMV endocarditis. The patient's past medical history was significant for human immunodeficiency virus, intravenous drug abuse, and chronic hepatitis B. During his clinical course, he was found to have tricuspid and mitral valve vegetations. After progressive valvular destruction despite antibiotic therapy, he underwent successful mitral and tricuspid valve replacement. Pathologic analysis of the culture-negative valve specimens were found to contain inclusion bodies consistent with CMV, and quantitative serum polymerase chain reaction returned a highly elevated CMV DNA count.
authors.affiliation: Midwestern University, Downers Grove, Illinois.
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Stear
authors.affiliation: Department of Cardiovascular and Thoracic Surgery, John H. Stroger Jr. Hospital, Chicago, Illinois.
authors.forename: David
authors.initials: D
authors.lastname: Shersher
authors.affiliation: Department of Pathology, John H. Stroger Jr. Hospital, Chicago, Illinois.
authors.forename: George J
authors.initials: GJ
authors.lastname: Kim
authors.affiliation: Department of Thoracic and Cardiac Surgery, Rush University Medical Center, Chicago, Illinois. Electronic address: douglas_r_smego@rush.edu.
authors.forename: Douglas R
authors.initials: DR
authors.lastname: Smego
mesh_terms: D001707:Biopsy, Needle; D003586:Cytomegalovirus Infections / Q000150:complications / Q000175:diagnosis*; D017548:Echocardiography, Transesophageal / Q000379:methods; D004696:Endocarditis / Q000000981:diagnostic imaging / Q000601:surgery* / Q000821:virology*; D005500:Follow-Up Studies; D006349:Heart Valve Diseases / Q000000981:diagnostic imaging / Q000601:surgery / Q000821:virology; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000473:pathology / Q000601:surgery* / Q000821:virology; D018570:Risk Assessment; D016896:Treatment Outcome; D014261:Tricuspid Valve / Q000473:pathology / Q000601:surgery* / Q000821:virology