title: Pregabalin for Refractory Radicular Leg Pain due to Lumbar Spinal Stenosis: A Preliminary Prospective Study.
abstract: We investigated the efficacy of pregabalin (PGB) for neuropathic leg pain in lumbar spinal stenosis (LSS) patients with disturbed activities of daily living (ADL)/quality of life (QOL) in a prospective observational study. Subjects were a total of 104 LSS patients with neuropathic pain (NeP) in leg and neurological intermittent claudication (IMC) refractory to nonsteroidal anti-inflammatory drugs (NSAIDs) for at least a month. NeP was identified using screening tool, Pain DETECT questionnaire. Visual analog scale (VAS) scores and responses to the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ) were assessed before and 6 weeks after PGB treatment initiation. Changes in IMC distance and adverse events were also recorded. PGB significantly improved their VAS scores for pain and sleep quality (P < 0.001). With respect to JOABPEQ, significant improvements were observed with regard to the following dimensions: pain-related disorders (P < 0.01), lumbar spine dysfunction (P = 0.031), gait disturbance (P = 0.028), and psychological disorders (P = 0.014). The IMC distance showed an improvement tendency after PGB treatment, albeit with no significance (P = 0.063). Minor adverse events such as dizziness were observed. PGB can be effective for neuropathic leg pain refractory to NSAIDs in LSS patients, resulting in not only pain control but also improving lower back pain-related ADL/QOL scores.
authors.affiliation: Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Sumihisa
authors.initials: S
authors.lastname: Orita
authors.affiliation: Department of Orthopaedic Surgery, Japan Community Health Care Organization Funabashi Central Hospital, Funabashi 273-0021, Japan.
authors.forename: Masaomi
authors.initials: M
authors.lastname: Yamashita
authors.affiliation: Department of Orthopaedic Surgery, Shimoshizu National Hospital, Yotsukaido 284-0003, Japan.
authors.forename: Yawara
authors.initials: Y
authors.lastname: Eguchi
authors.affiliation: Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Miyako
authors.initials: M
authors.lastname: Suzuki
authors.affiliation: Department of Orthopaedic Surgery, Kitasato University, Sagamihara 252-0375, Japan.
authors.forename: Gen
authors.initials: G
authors.lastname: Inoue
authors.affiliation: Department of Orthopaedic Surgery, Kitasato University, Sagamihara 252-0375, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Miyagi
authors.affiliation: Department of Orthopaedic Surgery, Tsuga Saito Orthopaedic Clinic, Chiba 264-0025, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Watanabe
authors.affiliation: Department of Orthopaedic Surgery, Showa University, Tokyo 142-8666, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Ozawa
authors.affiliation: Department of Orthopaedic Surgery, Chiba Cancer Center, Chiba 260-0801, Japan.
authors.forename: Hiroto
authors.initials: H
authors.lastname: Kamoda
authors.affiliation: Department of Orthopaedic Surgery, Sanmu Medical Center, Sanmu 289-1326, Japan.
authors.forename: Tetsuhiro
authors.initials: T
authors.lastname: Ishikawa
authors.affiliation: Department of Orthopaedic Surgery, Eastern Chiba Medical Center, Togane 283-8686, Japan.
authors.forename: Yasuchika
authors.initials: Y
authors.lastname: Aoki
authors.affiliation: Department of Orthopaedic Surgery, Kumagaya General Hospital, Kumagaya 360-0013, Japan.
authors.forename: Toshinori
authors.initials: T
authors.lastname: Ito
authors.affiliation: Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Go
authors.initials: G
authors.lastname: Kubota
authors.affiliation: Department of Orthopaedic Surgery, Shimoshizu National Hospital, Yotsukaido 284-0003, Japan.
authors.forename: Munetaka
authors.initials: M
authors.lastname: Suzuki
authors.affiliation: Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Kazuyo
authors.initials: K
authors.lastname: Yamauchi
authors.affiliation: Department of Orthopaedic Surgery, Japan Community Health Care Organization Chiba Hospital, Chiba 260-8710, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Hanaoka
authors.affiliation: Department of Orthopaedic Surgery, Chiba National Medical Center, Chiba 260-0042, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Sakuma
authors.affiliation: Department of Orthopaedic Surgery, Funabashi Municipal Medical Center, Funabashi 273-8588, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Shimbo
authors.affiliation: Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Oikawa
authors.affiliation: Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Takane
authors.initials: T
authors.lastname: Suzuki
authors.affiliation: Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Takahashi
authors.affiliation: Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Ohtori
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000700:Analgesics / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007564:Japan; D007866:Leg / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy* / Q000209:etiology*; D010147:Pain Measurement; D058748:Pain Perception / Q000187:drug effects; D000069583:Pregabalin / Q000627:therapeutic use*; D011446:Prospective Studies; D013130:Spinal Stenosis / Q000150:complications*; D055815:Young Adult
chemical_list: D000700:Analgesics; D000069583:Pregabalin