title: [Neurological complications and outcomes of bacterial meningitis in children].
abstract: OBJECTIVE
  To analyze neurological complications and outcomes of bacterial meningitis (BM) in children.
  
  
  METHODS
  Fifty-five patients with BM, aged from 2 months to 12 years, were examined. Bacteriological study, clinical and biochemical blood tests and blood serology and cerebrospinal fluid (CSF) tests as well as serum molecular-genetic study were performed. Neuroimaging methods (neurosonography, computed (X-ray) tomography and brain magnetic resonance imaging) were used.
  
  
  CONCLUSIONS
  A key role of generalized meningococcal infection in the development of BM in children was confirmed. Brain edema was an early and life-threatening complication of BM. It was found in 9% of the patients with meningococcal infection, 7.3% with pneumococcal meningitis and 3.6% with haemophilus meningitis. Changes in the brain structure were not found in 80% of the patients, in 20%, the residual stage of BM was characterized by cerebral destructive/proliferative or atrophic changes of different severity. The dissociation between clinical and neuroimaging parameters and poor outcomes of BM, related to the complicated premorbid state, concomitant somatic/neurological pathology, BM severity, late laboratory diagnosis and untimely etiotropic antibacterial treatment, were identified in 65.5%.
authors.affiliation: Russian Medical Academy of Postgraduate Education, Moscow, Russia; Bashlyaeva Children's City Clinical Hospital, Moscow, Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Milovanova
authors.affiliation: Russian Medical Academy of Postgraduate Education, Moscow, Russia; Bashlyaeva Children's City Clinical Hospital, Moscow, Russia.
authors.forename: L N
authors.initials: LN
authors.lastname: Mazankova
authors.affiliation: Russian Medical Academy of Postgraduate Education, Moscow, Russia.
authors.forename: D A
authors.initials: DA
authors.lastname: Moiseenkova
authors.affiliation: Infections Clinical Hospital #2, Moscow, Russia.
authors.forename: I A
authors.initials: IA
authors.lastname: Soldatova
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001921:Brain; D002648:Child; D006801:Humans; D008279:Magnetic Resonance Imaging; D016920:Meningitis, Bacterial / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D008583:Meningitis, Haemophilus; D008586:Meningitis, Pneumococcal / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents