title: Use of electrospinning to construct biomaterials for peripheral nerve regeneration.
abstract: A number of limitations associated with the use of hollow nerve guidance conduits (NGCs) require further discussion. Most importantly, the functional recovery outcomes after the placement of hollow NGCs are poor even after the successful bridging of peripheral nerve injuries. However, nerve regeneration scaffolds built using electric spinning have several advantages that may improve functional recovery. Thus, the present study summarizes recent developments in this area, including the key cells that are combined with the scaffold and associated with nerve regeneration, the structure and configuration of the electrospinning design (which determines the performance of the electrospinning scaffold), the materials the electrospinning fibers are composed of, and the methods used to control the morphology of a single fiber. Additionally, this study also discusses the processes underlying peripheral nerve regeneration. The primary goals of the present review were to evaluate and consolidate the findings of studies that used scaffolding biomaterials built by electrospinning used for peripheral nerve regeneration support. It is amazing that the field of peripheral nerve regeneration continues to consistently produce such a wide variety of innovative techniques and novel types of equipment, because the introduction of every new process creates an opportunity for advances in materials for nerve repair.
authors.forename: Qi
authors.initials: Q
authors.lastname: Quan
authors.forename: Biao
authors.initials: B
authors.lastname: Chang
authors.forename: Hao Ye
authors.initials: HY
authors.lastname: Meng
authors.forename: Ruo Xi
authors.initials: RX
authors.lastname: Liu
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.forename: Shi Bi
authors.initials: SB
authors.lastname: Lu
authors.forename: Jiang
authors.initials: J
authors.lastname: Peng
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhao
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology; D001672:Biocompatible Materials; D006801:Humans; D009416:Nerve Regeneration / Q000502:physiology*; D059348:Peripheral Nerve Injuries / Q000503:physiopathology*; D010525:Peripheral Nerves / Q000473:pathology / Q000503:physiopathology*; D020127:Recovery of Function / Q000502:physiology*
chemical_list: D001672:Biocompatible Materials