title: Volatile oil profile of some lamiaceous plants growing in Saudi Arabia and their biological activities.
abstract: A comparative investigation of hydro-distilled essential oils from aerial parts of Mentha longifolia L. (ML), Mentha microphylla K.Koch (MM), Mentha australis R.Br. (MA), and Teucrium polium L. (TP) growing in Al Madinah Al Munawwarah, Saudi Arabia, was carried out. The total numbers of identified constituents were 22, 23, 14, and 20 in ML, MM, MA, and TP oils, representing 93.0, 99.3, 78.1, and 81.1% of the total oil composition, respectively. Pulegone (40.7%) and cineole (33.4%) were the major components in ML, whereas carvone (64.6%) was the major one in MM. Furthermore, β-linalool (22.9%) and α-terpineol (12%) were the major components in MA, whereas, (E)-3-caren-2-ol accounted for 12.1% in TP. The essential oils of TP and MA exhibited promising activities against Leishmania donovani promastigotes with IC50 values of 2.3 and 3.7 μg/mL, respectively. In contrast, MA essential oils exhibited antifungal activities towards Candida krusei and C. glabrata with IC50 values of 1 and 1.2 μg/mL, respectively.
authors.affiliation: Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Al Madinah Al Munawwarah 30078, Saudi Arabia, E-mail: sribrahim@taibahu.edu.sa.
authors.forename: Sabrin R M
authors.initials: SRM
authors.lastname: Ibrahim
authors.affiliation: Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.|Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
authors.forename: Hossam M
authors.initials: HM
authors.lastname: Abdallah
authors.affiliation: Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.|Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, Egypt.
authors.forename: Gamal A
authors.initials: GA
authors.lastname: Mohamed
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Farag
authors.affiliation: Department of Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Khalid Z
authors.initials: KZ
authors.lastname: Alshali
authors.affiliation: Department of Botany, Faculty of Science, Beni Suef University, Beni Suef 62111, Egypt.|Department of Biology, Faculty of Science and Arts, Khulais, King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Emad A
authors.initials: EA
authors.lastname: Alsherif
authors.affiliation: National Center for Natural Products Research, Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University, MS 38677, USA.
authors.forename: Samir A
authors.initials: SA
authors.lastname: Ross
mesh_terms: D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology; D000981:Antiprotozoal Agents / Q000302:isolation & purification / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D005658:Fungi / Q000187:drug effects; D008401:Gas Chromatography-Mass Spectrometry; D007893:Leishmania donovani / Q000187:drug effects; D027541:Mentha / Q000737:chemistry*; D009822:Oils, Volatile / Q000302:isolation & purification* / Q000494:pharmacology; D010938:Plant Oils / Q000302:isolation & purification* / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects; D012529:Saudi Arabia; D013045:Species Specificity; D031367:Teucrium / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D000962:Antimalarials; D000981:Antiprotozoal Agents; D009822:Oils, Volatile; D010938:Plant Oils