title: Cortactin enhances exosome secretion without altering cargo.
abstract: The role of cortactin, a regulator of late endosomal trafficking, in the biogenesis and secretion of exosomes is poorly understood. In this issue, Sinha et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201601025) elucidate the role of cortactin as a positive regulator of late endosomal docking and exosome secretion.
authors.affiliation: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, 3086, Australia.
authors.forename: Lahiru
authors.initials: L
authors.lastname: Gangoda
authors.affiliation: Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, 3086, Australia s.mathivanan@latrobe.edu.au.
authors.forename: Suresh
authors.initials: S
authors.lastname: Mathivanan
mesh_terms: D051376:Actin-Related Protein 2-3 Complex / Q000378:metabolism; D001692:Biological Transport; D045744:Cell Line, Tumor; D051356:Cortactin / Q000378:metabolism*; D055354:Exosomes / Q000378:metabolism*; D006801:Humans
chemical_list: D051376:Actin-Related Protein 2-3 Complex; D051356:Cortactin