title: Constituents from the Roots of Actinidia chinensis and Their Cytochrome P450 Enzyme Inhibitory Activities.
abstract: A newly discovered triterpenoid, (2α,3β)-2,3,23-trihydroxyurs-13(18)-en-28-oic acid (1), along with twelve known compounds (2 - 13), were isolated from the roots of Actinidia chinensis Planch (Actinidiaceae). Their chemical structures were determined by 1D- and 2D-NMR spectra and mass spectrometry (MS). The crude extracts and six main constituents (8 - 13) were tested for cytochrome P450 (CYPs) enzyme inhibitory activity. The results showed that, except for compound 8, compounds 9 - 13 had different inhibitory effects on the cytochrome P450 (CYPs) enzyme, and compound 9 significantly inhibited the catalytic activities of CYP3A4 to < 10% of its control activities.
authors.affiliation: School of Pharmacy, Second Military Medical University, No. 325 Guohe Road, Shanghai, 200433, P. R. China.|School of Pharmacy, Shanghai University of Medical & Health Sciences, Shanghai, 200237, P. R. China.
authors.forename: Yi-Xin
authors.initials: YX
authors.lastname: Xu
authors.affiliation: Chongqing Key Laboratory of Catalysis & Functional Organic Molecules, Chongqing Technology and Business University, Chongqing, 400067, P. R. China.
authors.forename: Zhao-Bao
authors.initials: ZB
authors.lastname: Xiang
authors.affiliation: School of Pharmacy, Second Military Medical University, No. 325 Guohe Road, Shanghai, 200433, P. R. China.
authors.forename: Yong-Sheng
authors.initials: YS
authors.lastname: Jin
authors.affiliation: School of Pharmacy, Second Military Medical University, No. 325 Guohe Road, Shanghai, 200433, P. R. China.
authors.forename: Wen
authors.initials: W
authors.lastname: Xu
authors.affiliation: School of Pharmacy, Second Military Medical University, No. 325 Guohe Road, Shanghai, 200433, P. R. China.
authors.forename: Lian-Na
authors.initials: LN
authors.lastname: Sun
authors.affiliation: School of Pharmacy, Second Military Medical University, No. 325 Guohe Road, Shanghai, 200433, P. R. China.
authors.forename: Wan-Sheng
authors.initials: WS
authors.lastname: Chen
authors.affiliation: School of Pharmacy, Second Military Medical University, No. 325 Guohe Road, Shanghai, 200433, P. R. China.
authors.forename: Hai-Sheng
authors.initials: HS
authors.lastname: Chen
mesh_terms: D029042:Actinidia / Q000737:chemistry*; D065607:Cytochrome P-450 Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: C000613431:(2alpha,3beta)-2,3,23-trihydroxyurs-13(18)-en-28-oic acid; D065607:Cytochrome P-450 Enzyme Inhibitors; D014315:Triterpenes; D003577:Cytochrome P-450 Enzyme System
keywords: 
  Actinidia chinensis 
  Planch
  ; Actinidiaceae; Cytochrome P450 enzyme inhibitory activity; Drug metabolism; Triterpenoid