title: The dual regulatory role of miR-204 in cancer.
abstract: MicroRNAs (miRNAs) are a group of endogenous, small (about 22 nucleotides) non-coding RNAs which negatively regulate gene expressions. As one of them, miR-204 originates from the sixth intron of the transient receptor potential melastatin 3 (TRPM3) gene. Therefore, expression of miR-204 is under the control of the TRPM3 promoter and regulated by genetic and epigenetic mechanisms. miR-204 has been found to play the important roles in development of eyes and adipogenesis. Its pathological functions have been observed in a few diseases including pulmonary arterial hypertension, diabetes, and various types of cancers. It is believed that miR-204 acts as a tumor-suppressor via promoting apoptosis, conferring the resistance of cancer cells to chemotherapy, and suppressing the self-renewal of cancer stem cells (CSCs) and the epithelial to mesenchymal transition (EMT). Expression of miR-204 is repressed by its targets XRN1 and TRKB in prostate cancer and endometrial carcinoma, respectively; therefore, they establish an oncogenic feedback loops that play an important role promoting development of cancer. In this review, we summarize our current knowledge regarding miR-204, including its expression, regulation and biological functions, especially focusing our discussion on its role in tumor development and tumor progression.
authors.affiliation: Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai, China.
authors.forename: Tianqi
authors.initials: T
authors.lastname: Li
authors.affiliation: Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai, China.
authors.forename: Hongjie
authors.initials: H
authors.lastname: Pan
authors.affiliation: Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai, China. runshengli2007@163.com.
authors.forename: Runsheng
authors.identifier: http://orcid.org/0000-0001-7943-0625
authors.initials: R
authors.lastname: Li
mesh_terms: D050156:Adipogenesis; D000818:Animals; D005123:Eye / Q000196:embryology; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D009369:Neoplasms / Q000209:etiology* / Q000235:genetics; D014411:Neoplastic Stem Cells; D050053:TRPM Cation Channels / Q000235:genetics
chemical_list: C549404:MIRN204 microRNA, human; D035683:MicroRNAs; D050053:TRPM Cation Channels; C475667:TRPM3 protein, human
keywords: Cancer; Target gene; Tumor-suppresive gene; miR-204