title: Novel approaches to preclinical research and TB vaccine development.
abstract: The 4th Global Forum on TB Vaccines, convened in Shanghai, China, from 21 - 24 April 2015, brought together a wide and diverse community involved in tuberculosis vaccine research and development to discuss the current status of, and future directions for this critical effort. This paper summarizes the sessions on Low-Dose NHP Challenge Models, Novel Approaches to Animal Models for TB Vaccine R&D, Novel Antigen Delivery Strategies, and Next Generation TB Vaccines and Vaccine Concepts. Summaries of all sessions from the 4th Global Forum are compiled in a special supplement of Tuberculosis. [August 2016, Vol 99, Supp S1, S1-S30].
authors.affiliation: Aeras, Rockville, MD, USA. Electronic address: bwalker@aeras.org.
authors.forename: Kenneth Barry
authors.initials: KB
authors.lastname: Walker
authors.affiliation: Wuhan University, Wuhan, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Guo
authors.affiliation: Aeras, Rockville, MD, USA.
authors.forename: Yan
authors.initials: Y
authors.lastname: Guo
authors.affiliation: University of Geneva, Geneva, Switzerland.
authors.forename: Johanna
authors.initials: J
authors.lastname: Poecheim
authors.affiliation: Aeras, Rockville, MD, USA.
authors.forename: Kamalakannan
authors.initials: K
authors.lastname: Velmurugan
authors.affiliation: Aeras, Rockville, MD, USA.
authors.forename: Lewis K
authors.initials: LK
authors.lastname: Schrager
mesh_terms: D000336:Aerosols; D001500:BCG Vaccine / Q000276:immunology / Q000494:pharmacology; D002986:Clinical Trials as Topic; D016503:Drug Delivery Systems; D015195:Drug Design; D055808:Drug Discovery; D004353:Drug Evaluation, Preclinical; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D006801:Humans; D014376:Tuberculosis / Q000175:diagnosis / Q000235:genetics / Q000517:prevention & control*; D032581:Tuberculosis Vaccines / Q000276:immunology / Q000494:pharmacology*; D014613:Vaccines, Attenuated / Q000276:immunology / Q000494:pharmacology; D014614:Vaccines, Synthetic / Q000276:immunology / Q000494:pharmacology; D000097625:HLA-E Antigens
chemical_list: D000336:Aerosols; D001500:BCG Vaccine; D015395:Histocompatibility Antigens Class I; D032581:Tuberculosis Vaccines; D014613:Vaccines, Attenuated; D014614:Vaccines, Synthetic; D000097625:HLA-E Antigens
keywords: Animal models; TB pathogenesis; Tuberculosis; Vaccines