title: Effect of the Fusarium toxins, zearalenone and deoxynivalenol, on the mouse brain.
abstract: The aim of this study was to find effects of Fusarium toxins on brain injury in mice. We evaluated the individual and combined effect of the Fusarium toxins zearalenone and deoxynivalenol on the mouse brain. We examined brain weight, protein, antioxidant indicators, and apoptosis. After 3 and 5days of treatment, increased levels of nitric oxide, total nitric oxide synthase, hydroxyl radical scavenging, and malondialdehyde were observed in the treatment groups. This was accompanied by reduced levels of brain protein, superoxide dismutase (apart from the low-dose zearalenone groups), glutathione, glutathione peroxidase activity, and percentage of apoptotic cells. By day 12, most of these indicators had returned to control group levels. The effects of zearalenone and deoxynivalenol were dose-dependent, and were synergistic in combination. Our results suggest that brain function is affected by zearalenone and deoxynivalenol.
authors.affiliation: College of Veterinary Medicine, Sichuan Agricultural University, Sichuan Province Key Laboratory of Animal Disease & Human Health, Key Laboratory of Environmental Hazard and Human Health of Sichuan Province, Chengdu, 611130, China.
authors.forename: Z H
authors.initials: ZH
authors.lastname: Ren
authors.affiliation: College of Veterinary Medicine, Sichuan Agricultural University, Sichuan Province Key Laboratory of Animal Disease & Human Health, Key Laboratory of Environmental Hazard and Human Health of Sichuan Province, Chengdu, 611130, China.
authors.forename: H D
authors.initials: HD
authors.lastname: Deng
authors.affiliation: College of Veterinary Medicine, Sichuan Agricultural University, Sichuan Province Key Laboratory of Animal Disease & Human Health, Key Laboratory of Environmental Hazard and Human Health of Sichuan Province, Chengdu, 611130, China.
authors.forename: Y T
authors.initials: YT
authors.lastname: Deng
authors.affiliation: College of Veterinary Medicine, Sichuan Agricultural University, Sichuan Province Key Laboratory of Animal Disease & Human Health, Key Laboratory of Environmental Hazard and Human Health of Sichuan Province, Chengdu, 611130, China. Electronic address: dengjl213@126.com.
authors.forename: J L
authors.initials: JL
authors.lastname: Deng
authors.affiliation: College of Veterinary Medicine, Sichuan Agricultural University, Sichuan Province Key Laboratory of Animal Disease & Human Health, Key Laboratory of Environmental Hazard and Human Health of Sichuan Province, Chengdu, 611130, China.
authors.forename: Z C
authors.initials: ZC
authors.lastname: Zuo
authors.affiliation: College of Veterinary Medicine, Sichuan Agricultural University, Sichuan Province Key Laboratory of Animal Disease & Human Health, Key Laboratory of Environmental Hazard and Human Health of Sichuan Province, Chengdu, 611130, China.
authors.forename: S M
authors.initials: SM
authors.lastname: Yu
authors.affiliation: College of Veterinary Medicine, Sichuan Agricultural University, Sichuan Province Key Laboratory of Animal Disease & Human Health, Key Laboratory of Environmental Hazard and Human Health of Sichuan Province, Chengdu, 611130, China.
authors.forename: L H
authors.initials: LH
authors.lastname: Shen
authors.affiliation: College of Veterinary Medicine, Sichuan Agricultural University, Sichuan Province Key Laboratory of Animal Disease & Human Health, Key Laboratory of Environmental Hazard and Human Health of Sichuan Province, Chengdu, 611130, China.
authors.forename: H M
authors.initials: HM
authors.lastname: Cui
authors.affiliation: College of Veterinary Medicine, Sichuan Agricultural University, Sichuan Province Key Laboratory of Animal Disease & Human Health, Key Laboratory of Environmental Hazard and Human Health of Sichuan Province, Chengdu, 611130, China.
authors.forename: Z W
authors.initials: ZW
authors.lastname: Xu
authors.affiliation: College of Veterinary Medicine, Sichuan Agricultural University, Sichuan Province Key Laboratory of Animal Disease & Human Health, Key Laboratory of Environmental Hazard and Human Health of Sichuan Province, Chengdu, 611130, China.
authors.forename: Y C
authors.initials: YC
authors.lastname: Hu
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D017209:Apoptosis / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004798:Enzymes / Q000378:metabolism; D005260:Female; D005670:Fusarium / Q000737:chemistry*; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D018377:Neurotransmitter Agents / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D014255:Trichothecenes / Q000008:administration & dosage / Q000633:toxicity*; D015025:Zearalenone / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D000975:Antioxidants; D004798:Enzymes; D018377:Neurotransmitter Agents; D014255:Trichothecenes; D008315:Malondialdehyde; D015025:Zearalenone; C007262:deoxynivalenol
keywords: Antioxidant system; Brain injury; Deoxynivalenol; Synergistic effect; Zearalenone