title: Characterizing intestinal inflammation and fibrosis in Crohn's disease by photoacoustic imaging: feasibility study.
abstract: The pathology of Crohn's disease (CD) is characterized by obstructing intestinal strictures because of inflammation (with high levels of hemoglobin), fibrosis (high levels of collagen), or a combination of both. The accurate characterization of the strictures is critical for the management of CD. This study examines the feasibility of characterizing intestinal strictures by Photoacoustic imaging (PAI) without extrapolation from superficial biopsies. Ex vivo normal rat colon tissue, inflammatory and fibrotic intestinal strictures in rat trinitrobenzene sulfonic acid (TNBS) model were first differentiated by a PA-US parallel imaging system. Surgically removed human intestinal stricture specimens were afterwards imaged by a multiwavelength acoustic resolution PA microscope (ARPAM). The experiment results suggest that PAI is a potential tool for the diagnosis of the diseased conditions in intestinal strictures.
authors.affiliation: Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Hao
authors.initials: H
authors.lastname: Lei
authors.affiliation: Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
authors.forename: Laura A
authors.initials: LA
authors.lastname: Johnson
authors.affiliation: College of Physical Science and Technology, Heilongjiang University, Harbin, 150080, China; Department of Biomedical Engineering, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
authors.forename: Shengchun
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
authors.forename: David S
authors.initials: DS
authors.lastname: Moons
authors.affiliation: Department of Biomedical Engineering, NIH Ultrasonic Transducer Resource Center, University of Southern California, Los Angeles, CA 90089, USA.
authors.forename: Teng
authors.initials: T
authors.lastname: Ma
authors.affiliation: Department of Biomedical Engineering, NIH Ultrasonic Transducer Resource Center, University of Southern California, Los Angeles, CA 90089, USA.
authors.forename: Qifa
authors.initials: Q
authors.lastname: Zhou
authors.affiliation: Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Rice
authors.affiliation: Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Ni
authors.affiliation: Department of Biomedical Engineering, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Radiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
authors.forename: Xueding
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
authors.forename: Peter D R
authors.initials: PD
authors.lastname: Higgins
authors.affiliation: Department of Radiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
authors.forename: Guan
authors.initials: G
authors.lastname: Xu
keywords: (170.3880) Medical and biological imaging; (170.5120) Photoacoustic imaging; (170.7170) Ultrasound