title: Association of contrast-induced nephropathy with bare metal stent restenosis in STEMI patients treated with primary PCI.
abstract: BACKGROUND
  Contrast induced nephropathy (CIN) has been proven as a clinical condition related to adverse cardiovascular outcomes. However, relationship between CIN and stent restenosis (SR) remains unclear. In this study, we aimed to investigate the association of CIN with SR rates after primary percutaneous coronary intervention (PCI) and bare metal stent (BMS) implantation.
  
  
  METHODS
  A total number of 3225 patients who had undergone primary PCI for STEMI were retrospectively recruited. The medical reports of subjects were searched to find whether the patients had a control coronary angiogram (CAG) and 587 patients with control CAG were included in the study. The laboratory parameters of 587 patients were recorded and patients who developed CIN after primary PCI were defined. Contrast induced nephropathy was defined as either a 25% increase in serum creatinine from baseline or 0.5 mg/dL increase in absolute value, within 72 h of intravenous contrast administration.
  
  
  RESULTS
  The duration between primary PCI and control CAG was median 12 months [8-24 months]. The rate of SR was significantly higher in CIN (+) group compared to CIN (-) group (64% vs. 46%, p < 0.01). In multivariate Cox regression analysis, male gender, stent length, admission WBC levels and presence of CIN (HR 1.39, 95% CI 1.06-1.82, p < 0.01) remained as the independent predictors of SR in the study population.
  
  
  CONCLUSIONS
  Gender, stent length, higher serum WBC levels and presence of CIN are independently correlated with SR in STEMI patients treated with BMS implantation.
authors.affiliation: a Department of Cardiology , Siyami Ersek Cardiovascular and Thoracic Surgery Center , Istanbul , Turkey ;
authors.forename: Barış
authors.initials: B
authors.lastname: Güngör
authors.affiliation: a Department of Cardiology , Siyami Ersek Cardiovascular and Thoracic Surgery Center , Istanbul , Turkey ;
authors.forename: Mehmet Baran
authors.initials: MB
authors.lastname: Karataş
authors.affiliation: a Department of Cardiology , Siyami Ersek Cardiovascular and Thoracic Surgery Center , Istanbul , Turkey ;
authors.forename: Göktürk
authors.initials: G
authors.lastname: İpek
authors.affiliation: b Department of Cardiology , Derince Training and Research Hospital , Kocaeli , Turkey ;
authors.forename: Kazım Serhan
authors.initials: KS
authors.lastname: Özcan
authors.affiliation: a Department of Cardiology , Siyami Ersek Cardiovascular and Thoracic Surgery Center , Istanbul , Turkey ;
authors.forename: Yiğit
authors.initials: Y
authors.lastname: Çanga
authors.affiliation: a Department of Cardiology , Siyami Ersek Cardiovascular and Thoracic Surgery Center , Istanbul , Turkey ;
authors.forename: Tolga
authors.initials: T
authors.lastname: Onuk
authors.affiliation: a Department of Cardiology , Siyami Ersek Cardiovascular and Thoracic Surgery Center , Istanbul , Turkey ;
authors.forename: Muhammed
authors.initials: M
authors.lastname: Keskin
authors.affiliation: a Department of Cardiology , Siyami Ersek Cardiovascular and Thoracic Surgery Center , Istanbul , Turkey ;
authors.forename: Mert İlker
authors.initials: Mİ
authors.lastname: Hayıroğlu
authors.affiliation: c Department of Cardiology , Erzurum Training and Research Hospital , Erzurum , Turkey ;
authors.forename: Fatma Özpamuk
authors.initials: FÖ
authors.lastname: Karadeniz
authors.affiliation: d Department of Cardiology , Kahramanmaraş Necip Fazıl State Hospital , Kahramanmaraş , Turkey.
authors.forename: Aylin
authors.initials: A
authors.lastname: Sungur
authors.affiliation: a Department of Cardiology , Siyami Ersek Cardiovascular and Thoracic Surgery Center , Istanbul , Turkey ;
authors.forename: Recep
authors.initials: R
authors.lastname: Öztürk
authors.affiliation: a Department of Cardiology , Siyami Ersek Cardiovascular and Thoracic Surgery Center , Istanbul , Turkey ;
authors.forename: Osman
authors.initials: O
authors.lastname: Bolca
mesh_terms: D000368:Aged; D003287:Contrast Media / Q000009:adverse effects*; D017023:Coronary Angiography / Q000009:adverse effects*; D023903:Coronary Restenosis / Q000453:epidemiology* / Q000209:etiology; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D007674:Kidney Diseases / Q000139:chemically induced*; D016015:Logistic Models; D008297:Male; D008670:Metals; D008875:Middle Aged; D015999:Multivariate Analysis; D018384:Oxidative Stress / Q000187:drug effects; D062645:Percutaneous Coronary Intervention; D012189:Retrospective Studies; D012307:Risk Factors; D000072657:ST Elevation Myocardial Infarction / Q000601:surgery*; D015607:Stents / Q000009:adverse effects*; D014421:Turkey
chemical_list: D003287:Contrast Media; D008670:Metals; D003404:Creatinine
keywords: Contrast induced nephropathy; stent restenosis