title: Two new phenolic acids from the fruits of Forsythia suspense.
abstract: Two new phenolic acids forsythiayanoside C (1) and forsythiayanoside D (2), were isolated from the fruits of Forsythia suspense (Thunb.) Vahl. Their structures were elucidated on the basis of chemical and spectral analysis, including 1D, 2D NMR analyses, HRESIMS and CD spectrometry. The cytotoxic and antioxidant activities testing showed that compound 2 exhibited free radical scavenging activity.
authors.affiliation: a College of Pharmacy , Harbin University of Commerce , Harbin 150076 , China.|b School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.|c Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education) , Shenyang Pharmaceutical University , Shenyang 110016 , China.
authors.forename: Xin-Jia
authors.initials: XJ
authors.lastname: Yan
authors.affiliation: a College of Pharmacy , Harbin University of Commerce , Harbin 150076 , China.|b School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.|c Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education) , Shenyang Pharmaceutical University , Shenyang 110016 , China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wen
authors.affiliation: a College of Pharmacy , Harbin University of Commerce , Harbin 150076 , China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Xiang
authors.affiliation: c Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education) , Shenyang Pharmaceutical University , Shenyang 110016 , China.
authors.forename: Dong
authors.initials: D
authors.lastname: Cai
authors.affiliation: b School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.|c Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education) , Shenyang Pharmaceutical University , Shenyang 110016 , China.
authors.forename: Chong-Ning
authors.initials: CN
authors.lastname: Lv
authors.affiliation: a College of Pharmacy , Harbin University of Commerce , Harbin 150076 , China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: a College of Pharmacy , Harbin University of Commerce , Harbin 150076 , China.
authors.forename: Zhong-Yuan
authors.initials: ZY
authors.lastname: Qu
authors.affiliation: a College of Pharmacy , Harbin University of Commerce , Harbin 150076 , China.
authors.forename: Yu-Jia
authors.initials: YJ
authors.lastname: Liu
authors.affiliation: b School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.|c Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education) , Shenyang Pharmaceutical University , Shenyang 110016 , China.
authors.forename: Jia-Lin
authors.initials: JL
authors.lastname: Qu
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031657:Forsythia / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D062385:Hydroxybenzoates / Q000737:chemistry / Q000302:isolation & purification*; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010084:Oxidation-Reduction
chemical_list: D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D016166:Free Radical Scavengers; D006027:Glycosides; D062385:Hydroxybenzoates; D017705:Lignans; C000616491:forsythiayanoside C; C000616492:forsythiayanoside D; C017616:phenolic acid
keywords: Forsythia suspense; Oleaceae; antioxidant activity; cytotoxic activity; phenolic acid