title: Elevated Levels of Adhesion Proteins Are Associated With Low Ankle-Brachial Index.
abstract: Inflammation plays a pivotal role in peripheral artery disease (PAD). Cellular adhesion proteins mediate the interaction of leukocytes with endothelial cells during inflammation. To determine the association of cellular adhesion molecules with ankle-brachial index (ABI) and ABI category (≤1.0 vs >1.0) in a diverse population, 15 adhesion proteins were measured in the Multi-Ethnic Study of Atherosclerosis (MESA). To assess multivariable associations of each protein with ABI and ABI category, linear and logistic regression was used, respectively. Among 2364 participants, 23 presented with poorly compressible arteries (ABI > 1.4) and were excluded and 261 had ABI ≤ 1.0. Adjusting for traditional risk factors, elevated levels of soluble P-selectin, hepatocyte growth factor, and secretory leukocyte protease inhibitor were associated with lower ABI ( P = .0004, .001, and .002, respectively). Per each standard deviation of protein, we found 26%, 20%, and 19% greater odds of lower ABI category ( P = .001, .01, and .02, respectively). Further investigation into the adhesion pathway may shed new light on biological mechanisms implicated in PAD.
authors.affiliation: 1 Department of Internal Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA.|2 Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Berardi
authors.affiliation: 3 Department of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Colchester, VT, USA.
authors.forename: Christine L
authors.initials: CL
authors.lastname: Wassel
authors.affiliation: 2 Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Decker
authors.affiliation: 2 Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
authors.forename: Nicholas B
authors.initials: NB
authors.lastname: Larson
authors.affiliation: 2 Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
authors.forename: Phillip S
authors.initials: PS
authors.lastname: Kirsch
authors.affiliation: 2 Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
authors.forename: Mariza de
authors.initials: M
authors.lastname: Andrade
authors.affiliation: 4 Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Michael Y
authors.initials: MY
authors.lastname: Tsai
authors.affiliation: 5 Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.
authors.forename: James S
authors.initials: JS
authors.lastname: Pankow
authors.affiliation: 6 Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
authors.forename: Michele M
authors.initials: MM
authors.lastname: Sale
authors.affiliation: 2 Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
authors.forename: Hugues
authors.initials: H
authors.lastname: Sicotte
authors.affiliation: 5 Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Weihong
authors.initials: W
authors.lastname: Tang
authors.affiliation: 4 Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Naomi Q
authors.initials: NQ
authors.lastname: Hanson
authors.affiliation: 7 Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
authors.forename: Mary M
authors.initials: MM
authors.lastname: McDermott
authors.affiliation: 8 Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, USA.
authors.forename: Michael H
authors.initials: MH
authors.lastname: Criqui
authors.affiliation: 8 Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Allison
authors.affiliation: 2 Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
authors.forename: Suzette J
authors.initials: SJ
authors.lastname: Bielinski
mesh_terms: D000368:Aged; D055109:Ankle Brachial Index; D050197:Atherosclerosis / Q000097:blood* / Q000208:ethnology; D015415:Biomarkers / Q000097:blood; D015815:Cell Adhesion Molecules / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000097:blood* / Q000208:ethnology; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D015815:Cell Adhesion Molecules
keywords: P-selectin; ankle–brachial index; hepatocyte growth factor; peripheral artery disease; secretory leukocyte protease inhibitor