title: Fertility-sparing management and obstetric outcomes in a 20-year-old patient with a Sertoli-Leydig cell tumor of the ovary: A case report and review of the literature.
abstract: Sertoli-Leydig cell tumors (SLCTs) are an uncommon subtype of sex-cord stromal tumors of the ovary, which most commonly arise in women of reproductive age, creating an issue with regard to the preservation of fertility. The clinical manifestation of SLCTs varies widely, ranging from an asymptomatic clinical profile to extreme virilization. Correct diagnosis of SLCT is crucial and is primarily based on histopathological results. The current study presents the case of a 20-year-old woman who underwent unilateral salpingo-oophorectomy and adjuvant chemotherapy due to the diagnosis of an SLCT of the left ovary. Almost 2 years after the initial surgery, during the follow-up period, the patient conceived normally. Pregnancy was uneventful and the patient vaginally delivered a healthy infant at 38 weeks of gestation. A total of 1 year after delivery (3 years after the initial diagnosis), follow-up of the patient did not reveal any disease recurrence. In conclusion, SLCTs may be adequately treated by fertility-sparing surgery and chemotherapy in young women who wish to preserve their fertility. Natural conception, an uncomplicated pregnancy and a vaginal delivery are possible.
authors.affiliation: Third Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece.
authors.forename: Thomas
authors.initials: T
authors.lastname: Stavrakis
authors.affiliation: Third Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Kalogiannidis
authors.affiliation: Third Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece.
authors.forename: Stamatios
authors.initials: S
authors.lastname: Petousis
authors.affiliation: Department of Pathology, 'Agios Dimitrios' General Hospital, 54634 Thessaloniki, Greece.
authors.forename: Chrisoula
authors.initials: C
authors.lastname: Tsompanidou
authors.affiliation: Third Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece.
authors.forename: Dimitris
authors.initials: D
authors.lastname: Delkos
authors.affiliation: Third Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Prapas
authors.affiliation: Third Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece.
authors.forename: David
authors.initials: D
authors.lastname: Rousso
keywords: Sertoli-Leydig cell tumor; fertility-sparing surgery; hyperandrogonemia; sex-cord stromal tumor; virilization