title: Mumps virus pathogenesis: Insights and knowledge gaps.
abstract: The recent mumps outbreaks among MMR vaccinated persons have raised questions about the biological mechanisms related to mumps symptoms and complications in the background of waning immunity. Contrary to other paramyxoviruses, the understanding of mumps virus pathogenesis is limited, and further in-depth clinical studies are required to provide answers to important research questions.
authors.affiliation: a Centre for Infectious Disease Control , National Institute for Public Health and the Environment (RIVM) , Bilthoven , The Netherlands.|b Department of Viroscience , Erasmus University Medical Centre , Rotterdam , The Netherlands.
authors.forename: Sigrid
authors.initials: S
authors.lastname: Gouma
authors.affiliation: a Centre for Infectious Disease Control , National Institute for Public Health and the Environment (RIVM) , Bilthoven , The Netherlands.|b Department of Viroscience , Erasmus University Medical Centre , Rotterdam , The Netherlands.
authors.forename: Marion P G
authors.initials: MP
authors.lastname: Koopmans
authors.affiliation: a Centre for Infectious Disease Control , National Institute for Public Health and the Environment (RIVM) , Bilthoven , The Netherlands.
authors.forename: Rob S
authors.initials: RS
authors.lastname: van Binnendijk
mesh_terms: D002648:Child; D002675:Child, Preschool; D006801:Humans; D019359:Knowledge; D009107:Mumps / Q000473:pathology* / Q000503:physiopathology*; D009109:Mumps virus / Q000472:pathogenicity*
keywords: MMR vaccination; Mumps virus; T cell immunity; mucosal immunity; orchitis; parotitis; symptoms; viruria