title: Does Emotion Dysregulation Mediate the Relationship between Early Maltreatment and Later Substance Dependence? Findings of the CANSAS Study.
abstract: OBJECTIVE
  Maltreatment in childhood and adolescence is a risk factor for substance use disorders (SUDs) in adulthood. This association has rarely been investigated in the light of emotion dysregulation. To fill this gap, this study examines emotion dysregulation and SUDs among adults with a history of early maltreatment.
  
  
  METHODS
  Comparison of emotion dysregulation in adults with a history of early abuse and neglect who developed either an SUD (n = 105) or no mental disorder (n = 54). Further, a mediation model for the association between the severity of early maltreatment and SUDs was tested. Participants completed research diagnostic interviews for psychopathology, the Difficulties in Emotion Regulation Scale, and the Childhood Trauma Questionnaire.
  
  
  RESULTS
  By using hierarchical regression techniques and mediational analyses controlling for age and gender, it was possible to provide evidence for the mediating role of emotion dysregulation between early emotional and physical maltreatment and later SUDs.
  
  
  CONCLUSIONS
  Emotion dysregulation is a potential mechanism underlying the relationship between early emotional and physical maltreatment and the development of SUDs. In light of these findings, focusing on the early training of adaptive emotion regulation strategies after childhood maltreatment might be of considerable relevance to prevent the development of SUDs.
authors.affiliation: Department of Clinical Psychology and Psychotherapy, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Wolff
authors.forename: Julia
authors.initials: J
authors.lastname: Holl
authors.forename: Malte
authors.initials: M
authors.lastname: Stopsack
authors.forename: Elisabeth A
authors.initials: EA
authors.lastname: Arens
authors.forename: Anja
authors.initials: A
authors.lastname: Höcker
authors.forename: Katharina A
authors.initials: KA
authors.lastname: Staben
authors.forename: Philipp
authors.initials: P
authors.lastname: Hiller
authors.forename: Michael
authors.initials: M
authors.lastname: Klein
authors.forename: Ingo
authors.initials: I
authors.lastname: Schäfer
authors.forename: Sven
authors.initials: S
authors.lastname: Barnow
mesh_terms: D000328:Adult; D000342:Affective Symptoms / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology*; D002648:Child; D002649:Child Abuse / Q000523:psychology*; D004644:Emotions; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology*; D011795:Surveys and Questionnaires; D013997:Time Factors; D055815:Young Adult