title: Interleukin 1α and the inflammatory process.
abstract: Inflammation occurs after disruption of tissue homeostasis by cell stress, injury or infection and ultimately involves the recruitment and retention of cells of hematopoietic origin, which arrive at the affected sites to resolve damage and initiate repair. Interleukin 1α (IL-1α) and IL-1β are equally potent inflammatory cytokines that activate the inflammatory process, and their deregulated signaling causes devastating diseases manifested by severe acute or chronic inflammation. Although much attention has been given to understanding the biogenesis of IL-1β, the biogenesis of IL-1α and its distinctive role in the inflammatory process remain poorly defined. In this review we examine key aspects of IL-1α biology and regulation and discuss its emerging importance in the initiation and maintenance of inflammation that underlie the pathology of many human diseases.
authors.affiliation: Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.
authors.forename: Nelson C
authors.initials: NC
authors.lastname: Di Paolo
authors.affiliation: Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.|Center for Transplantation and Immune-mediated Disorders, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.|Emory Vaccine Center, Departments of Pediatrics and Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
authors.forename: Dmitry M
authors.initials: DM
authors.lastname: Shayakhmetov
mesh_terms: D000067531:Alarmins / Q000378:metabolism; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D005786:Gene Expression Regulation; D006099:Granuloma / Q000209:etiology / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000503:physiopathology*; D053582:Interleukin-1alpha / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D008264:Macrophages / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D008954:Models, Biological; D009369:Neoplasms / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D011485:Protein Binding; D014176:Protein Biosynthesis; D011499:Protein Processing, Post-Translational; D017472:Receptors, Interleukin-1 / Q000502:physiology; D015398:Signal Transduction
chemical_list: D000067531:Alarmins; C508584:IL1A protein, human; D053582:Interleukin-1alpha; D017472:Receptors, Interleukin-1