title: High-grade undifferentiated pleomorphic sarcoma of the pelvis: A case report and review of literature.
abstract: High-grade spindle cell sarcomas are rare undifferentiated pleomorphic cancers that present a treatment challenge to urological practices, especially when they present in the pelvis. We report a 46-year-old male patient who presented to our urology clinic with urinary retention after having a Foley catheter placed at an outlying facility. A voiding trial was attempted, but the patient failed this trial. This failure resulted in cystoscopy with bilateral retrograde pyelograms, which revealed a compressed bladder due to extrinsic compression. This finding had been evaluated with a computed tomography (CT) scan with and without intravenous contrast that showed a 14 cm pelvic mass with bladder displacement and compression. A fine needle aspiration was done at this outlying facility, prior to referral to our office, and it confirmed spindle cell pathology. The mass was surgically excised with the histology revealing a pelvic spindle cell sarcoma with positive surgical margins. Further, metastatic work-up with CT/positron emission tomography revealed bone and lung metastasis. The patient is currently undergoing chemotherapy and radiation. In this case study, we will review staging, management, differential diagnosis, chemotherapy, and radiation.
authors.affiliation: West Virginia School of Osteopathic Medicine, West Virginia, USA.
authors.forename: Slava
authors.initials: S
authors.lastname: Agafonoff
authors.affiliation: Vaidya Urology Clinic, West Virginia, USA.
authors.forename: Shrikant K
authors.initials: SK
authors.lastname: Vaidya
authors.affiliation: Bellefonte Urological Service, Kentucky, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: DeFade
keywords: Pleomorphic sarcoma; retroperitoneum; soft tissue sarcoma; spindle cells