title: New strategies for improving stem cell therapy in ischemic heart disease.
abstract: Stem cell therapy is a promising approach to the treatment of ischemic heart disease via replenishing cell loss after myocardial infarction. Both preclinical studies and clinical trials have indicated that cardiac function improved consistently, but very modestly after cell-based therapy. This mainly attributed to low cell survival rate, engraftment and functional integration, which became the major challenges to regenerative medicine. In recent years, several new cell types have been developed to regenerate cardiomyocytes and novel delivery approaches helped to increase local cell retention. New strategies, such as cell pretreatment, gene-based therapy, tissue engineering, extracellular vesicles application and immunologic regulation, have surged and brought about improved cell survival and functional integration leading to better therapeutic effects after cell transplantation. In this review, we summarize these new strategies targeting at challenges of cardiac regenerative medicine and discuss recent evidences that may hint their effectiveness in the future clinical settings.
authors.affiliation: State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College, Chinese Academy of Medical Science, 167 Beilishi Road, West District, Beijing, 100037, China.
authors.forename: Peisen
authors.initials: P
authors.lastname: Huang
authors.affiliation: State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College, Chinese Academy of Medical Science, 167 Beilishi Road, West District, Beijing, 100037, China.
authors.forename: Xiaqiu
authors.initials: X
authors.lastname: Tian
authors.affiliation: State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College, Chinese Academy of Medical Science, 167 Beilishi Road, West District, Beijing, 100037, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
authors.affiliation: State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College, Chinese Academy of Medical Science, 167 Beilishi Road, West District, Beijing, 100037, China. yangyjfw@126.com.
authors.forename: Yuejin
authors.initials: Y
authors.lastname: Yang
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D015316:Genetic Therapy; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000235:genetics*; D017202:Myocardial Ischemia / Q000628:therapy*; D032383:Myocytes, Cardiac / Q000166:cytology*; D016032:Randomized Controlled Trials as Topic; D051381:Rats; D012038:Regeneration / Q000235:genetics; D033581:Stem Cell Transplantation / Q000379:methods*; D023822:Tissue Engineering
chemical_list: D035683:MicroRNAs
keywords: Exosomes; Ischemic heart disease; MicroRNAs; Stem cell transplantation; Tissue engineering; Transplantation immunology