title: Helicobacter pylori infection may increase the risk of progression of chronic hepatitis B disease among the Chinese population: a meta-analysis.
abstract: OBJECTIVE
  Helicobacter pylori is a bacterium that infects over 50% of the human population worldwide. An increasing number of studies have demonstrated that H. pylori may cause liver diseases, and the underlying relationship between H. pylori infection and chronic hepatitis B has attracted much attention. This study aimed to examine the association between H. pylori infection and the progression of chronic hepatitis B in the Chinese population.
  
  
  METHODS
  A search was performed of the PubMed/MEDLINE, Web of Science, and Cochrane Central Register of Controlled Trials (CENTRAL) databases, as well as the Chinese databases, China National Knowledge Infrastructure and Wanfang Data, for studies published between January 1, 1994 and November 1, 2015.
  
  
  RESULTS
  In total, 2977 patients were included in the chronic hepatitis B group, while 1668 participants were included in the healthy control group. The prevalence of H. pylori among patients with chronic hepatitis B was significantly higher than that among those without chronic hepatitis B. The pooled odds ratio was 3.17. In the subgroup analysis, the odds ratio was 4.28 for hepatitis B virus (HBV)-related cirrhosis and 6.02 for hepatocellular carcinoma.
  
  
  CONCLUSIONS
  These results indicate a strong relationship between H. pylori and chronic hepatitis B, particularly during HBV progression.
authors.affiliation: Department of Infectious Diseases, Xiangya Hospital, Central South University, Xiangya Road 87, Changsha, Hunan Province, 410008, China; Key Laboratory of Viral Hepatitis, Hunan Province, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Infectious Diseases, Xiangya Hospital, Central South University, Xiangya Road 87, Changsha, Hunan Province, 410008, China; Key Laboratory of Viral Hepatitis, Hunan Province, China.
authors.forename: Ruo-Chan
authors.initials: RC
authors.lastname: Chen
authors.affiliation: Department of Infectious Diseases, Xiangya Hospital, Central South University, Xiangya Road 87, Changsha, Hunan Province, 410008, China; Key Laboratory of Viral Hepatitis, Hunan Province, China.
authors.forename: Yi-Xiang
authors.initials: YX
authors.lastname: Zheng
authors.affiliation: Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Shu-Shan
authors.initials: SS
authors.lastname: Zhao
authors.affiliation: Department of Blood Transfusion, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.affiliation: Department of Infectious Diseases, Xiangya Hospital, Central South University, Xiangya Road 87, Changsha, Hunan Province, 410008, China; Key Laboratory of Viral Hepatitis, Hunan Province, China.
authors.forename: Rong-Rong
authors.initials: RR
authors.lastname: Zhou
authors.affiliation: Department of Infectious Diseases, Xiangya Hospital, Central South University, Xiangya Road 87, Changsha, Hunan Province, 410008, China; Key Laboratory of Viral Hepatitis, Hunan Province, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Infectious Diseases, Xiangya Hospital, Central South University, Xiangya Road 87, Changsha, Hunan Province, 410008, China; Key Laboratory of Viral Hepatitis, Hunan Province, China. Electronic address: 36165934@qq.com.
authors.forename: Ze-Bing
authors.initials: ZB
authors.lastname: Huang
authors.affiliation: Department of Infectious Diseases, Xiangya Hospital, Central South University, Xiangya Road 87, Changsha, Hunan Province, 410008, China; Key Laboratory of Viral Hepatitis, Hunan Province, China. Electronic address: xgfan57@126.com.
authors.forename: Xue-Gong
authors.initials: XG
authors.lastname: Fan
mesh_terms: D002681:China / Q000453:epidemiology; D018450:Disease Progression; D016481:Helicobacter Infections / Q000150:complications* / Q000382:microbiology; D016480:Helicobacter pylori / Q000235:genetics / Q000502:physiology; D006515:Hepatitis B virus / Q000235:genetics / Q000502:physiology; D019694:Hepatitis B, Chronic / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology / Q000821:virology; D006801:Humans; D008113:Liver Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000473:pathology / Q000821:virology
keywords: Chronic hepatitis B; Cirrhosis; Helicobacter pylori; Hepatocellular carcinoma