title: A Novel Application of Ti-Substituted Polyoxometalates: Anti-Inflammatory Activity in OVA-Induced Asthma Murine Model.
abstract: Objective. Asthma is a chronic inflammatory disorder. Despite extensive researches into the treatment and management of it, current treatments and management strategies are still limited. The search for a novel approach to its treatments is urgently needed. Researches on the potential medical use of polyoxometalates (POMs) have already shown it has antiviral and antitumor bioactivities. But the effects of POM in immune systems are still largely unknown. Methods. In order to investigate the role of POM in the asthmatic disease, we used OVA-induced asthma murine model and observed the pathological changes between mice that received three different Ti-substituted POMs (0.3 μg per mouse per dose) when challenged with OVA. We also measured the type 2 cytokine expressions to reveal the potential mechanism. Results and Conclusions. Our results showed that two Ti-substituted POMs, K5H2[FeW11TiO40]·17H2O and K5H[H2ZnW11TiO40]·35H2O, could reduce OVA-induced lung inflammation, serum IgE level (around 2000 ng/mL to less than 1000 ng/mL), leukocytes infiltration in the lung, and cytokines levels (including IL-4, IL-5, IL-13, and TNF-α) but Ti-centered POM K4[TiW12O40]·10H2O did not. Thus, Ti-substituted POMs may have pharmaceutical values especially in treatments for asthmatic diseases.
authors.affiliation: Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China.
authors.forename: Dong
authors.identifier: 0000-0002-2508-3282
authors.initials: D
authors.lastname: Li
authors.affiliation: Department of Hepatology, First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Xiuzhu
authors.initials: X
authors.lastname: Gao
authors.affiliation: College of Veterinary Medicine, Jilin University, Changchun 130062, China.
authors.forename: Jingmin
authors.identifier: 0000-0002-3522-195X
authors.initials: J
authors.lastname: Gu
authors.affiliation: Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Tian
authors.affiliation: Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China.
authors.forename: Yaqing
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Jin
authors.affiliation: Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Yan
authors.affiliation: Key Laboratory of Polyoxometalates Science of Ministry of Education, Faculty of Chemistry, Northeast Normal University, Changchun 130024, China.
authors.forename: Ya-Guang
authors.identifier: 0000-0002-5369-2229
authors.initials: YG
authors.lastname: Chen
authors.affiliation: Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China.
authors.forename: Xun
authors.initials: X
authors.lastname: Zhu