title: [LOCAL ANTIBIOTIC THERAPY OF OSTEOMYELITIS USING NONABSORBABLE IMPLANT (REVIEW)].
abstract: Despite the variety of treatments available, including surgical procedures and antimicrobial therapy, bone infections is still a medical problem, because they are difficult to treat. Optimal treatment should stabilize the bone, promote the biological recovery of bone defects and destroy bacterial infection. Systemic antibiotics are part of the standard therapy after surgical treatment of infected bone, but their effectiveness is limited due to malnutrition and low absorption at the site of infection. Moreover, long-term treatment and higher doses are associated with serious side effects. In contrast, the antibiotic impregnated bone cements or fillers can act as a local anti-infective drug delivery system, which not only fills the dead space after debridement, but also provide high concentrations of antibiotics in a potential site of infection, no increase levels of antibiotics in serum. The review analyzed the use of antibiotic-impregnated cement as local delivery of antibiotics systems. Gentamycin impregnated polymethylmethacrylate (PMMA) beads, for the topical treatment of orthopedic infections clinically used for over 30 years. Application of antibiotic delivery systems using cement in the infected region is common method of treatment that continues to improve. On the downside of PMMA is that the material does not biodegradable requires subsequent invasive procedures necessary to remove the implant.
authors.affiliation: Karaganda State Medical University, Karaganda, Kazakhstan.
authors.forename: B
authors.initials: B
authors.lastname: Tuleubaev
authors.affiliation: Karaganda State Medical University, Karaganda, Kazakhstan.
authors.forename: D
authors.initials: D
authors.lastname: Saginova
authors.affiliation: Karaganda State Medical University, Karaganda, Kazakhstan.
authors.forename: T
authors.initials: T
authors.lastname: Abiyev
authors.affiliation: Karaganda State Medical University, Karaganda, Kazakhstan.
authors.forename: M
authors.initials: M
authors.lastname: Davletbaev
authors.affiliation: Karaganda State Medical University, Karaganda, Kazakhstan.
authors.forename: A
authors.initials: A
authors.lastname: Koshanova
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001843:Bone Cements / Q000627:therapeutic use; D016503:Drug Delivery Systems; D005839:Gentamicins / Q000008:administration & dosage; D006801:Humans; D010019:Osteomyelitis / Q000188:drug therapy*; D019904:Polymethyl Methacrylate
chemical_list: D000900:Anti-Bacterial Agents; D001843:Bone Cements; D005839:Gentamicins; D019904:Polymethyl Methacrylate