title: Platelet-Rich Fibrin With 1.2% Rosuvastatin for Treatment of Intrabony Defects in Chronic Periodontitis: A Randomized Controlled Clinical Trial.
abstract: Regenerative periodontal therapy encompasses use of various bioactive agents that are not only inflammomodulatory but also osteoclast-inhibitory or, rather, osteostimulative. Hypolipidemic statin drugs, particularly rosuvastatin (RSV), are known to be associated with alveolar bone formation and periodontal improvements. Platelet analogs such as platelet-rich fibrin (PRF), being rich sources of growth factors, have also come into widespread periodontal regenerative use. The aim of this study is to evaluate and compare efficacy of open flap debridement (OFD) with or without PRF or PRF + 1.2% RSV gel in treatment of intrabony defects (IBDs) in patients with chronic periodontitis (CP).
  
  
  
  Ninety individuals with a total of 90 IBDs were randomly assigned to one of three treatment groups: 1) OFD alone; 2) OFD + PRF; and 3) OFD + PRF + 1.2% RSV gel placement. Measurements recorded at baseline and 9 months after surgery were: 1) plaque index (PI); 2) modified sulcus bleeding index (mSBI); 3) probing depth (PD); 4) clinical attachment level (CAL); and 5) IBD depth.
  
  
  
  Significant PI and mSBI reductions were observed in all three groups. PRF placement significantly enhanced improvements in periodontal parameters compared with OFD alone. Addition of 1.2% RSV gel to PRF resulted in significantly greater CAL gain and PD and IBD depth reductions over 9 months compared with other groups.
  
  
  
  OFD with RSV (1.2%) and PRF results in significantly greater periodontal benefits compared with OFD alone or with PRF.
authors.affiliation: Department of Periodontology, Government Dental College and Research Institute, Bengaluru, Karnataka, India.
authors.forename: A R
authors.initials: AR
authors.lastname: Pradeep
authors.affiliation: Department of Periodontology, Government Dental College and Research Institute, Bengaluru, Karnataka, India.
authors.forename: Vibhuti
authors.initials: V
authors.lastname: Garg
authors.affiliation: Department of Periodontology, Government Dental College and Research Institute, Bengaluru, Karnataka, India.
authors.forename: Dharmendra
authors.initials: D
authors.lastname: Kanoriya
authors.affiliation: Department of Periodontology, Government Dental College and Research Institute, Bengaluru, Karnataka, India.
authors.forename: Sandeep
authors.initials: S
authors.lastname: Singhal
mesh_terms: D016301:Alveolar Bone Loss; D055113:Chronic Periodontitis / Q000188:drug therapy*; D005337:Fibrin; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D010512:Periodontal Index; D000073183:Platelet-Rich Fibrin; D000068718:Rosuvastatin Calcium / Q000627:therapeutic use*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000068718:Rosuvastatin Calcium; D005337:Fibrin
keywords: Alveolar bone loss; chronic periodontitis; periodontium; regeneration; rosuvastatin calcium; surgery