title: Molecular mechanisms of action of quercetin in cancer: recent advances.
abstract: In the last few decades, the scientific community has discovered an immense potential of natural compounds in the treatment of dreadful diseases such as cancer. Besides the availability of a variety of natural bioactive molecules, efficacious cancer therapy still needs to be developed. So, to design an efficacious cancer treatment strategy, it is essential to understand the interactions of natural molecules with their respective cellular targets. Quercetin (Quer) is a naturally occurring flavonol present in many commonly consumed food items. It governs numerous intracellular targets, including the proteins involved in apoptosis, cell cycle, detoxification, antioxidant replication, and angiogenesis. The weight of available synergistic studies vigorously fortifies the utilization of Quer as a chemoprevention drug. This extensive review covers various therapeutic interactions of Quer with their recognized cellular targets involved in cancer treatment.
authors.affiliation: Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, Punjab, 160012, India.
authors.forename: Dharambir
authors.initials: D
authors.lastname: Kashyap
authors.affiliation: School of Biotechnology, Jawaharlal Nehru University, New Delhi, 110067, India.
authors.forename: Sonam
authors.initials: S
authors.lastname: Mittal
authors.affiliation: Department of Hematology and Oncology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia.
authors.forename: Katrin
authors.initials: K
authors.lastname: Sak
authors.affiliation: Department of Biotechnology, Maharishi Markandeshwar University, Mullana, Ambala, 133203, India.
authors.forename: Paavan
authors.initials: P
authors.lastname: Singhal
authors.affiliation: Department of Biotechnology, Maharishi Markandeshwar University, Mullana, Ambala, 133203, India. hardeep.biotech@gmail.com.
authors.forename: Hardeep Singh
authors.initials: HS
authors.lastname: Tuli
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D011794:Quercetin / Q000494:pharmacology*
chemical_list: D016588:Anticarcinogenic Agents; D000975:Antioxidants; D011794:Quercetin
keywords: Anti-angiogenesis; Anti-metastasis; Apoptosis; Cell cycle; Quercetin; Toxicity