title: Effects of magnesium sulfate on airway smooth muscle contraction in rats.
abstract: Aim To investigate the effect of magnesium sulfate (MgSO4) at different doses on isolated tracheal smooth muscle contraction in rats induced by different mechanisms. Methods Twelve rats' tracheas were placed into organ bath. Consecutively, acetylcholine (10-6,10-5,10-4 M), histamine(10-8,10-5,10-3 M) and KCl (30,60 mM) solutions was administered for contractions. MgSO4 from 10-4 to 10-1 M concentrations were subsequently administered after each constrictive agent and relaxation degrees were recorded. Results In the acetylcholine and KCl groups, dose dependent strong contractions were observed, but not in the histamine group and that group was excluded. Significant relaxation occurred with gradually increasing doses of MgSO4. In the high dose KCl group, a slight increase in contractions after the administration of 10-4 and 10-3 M MgSO4 was recorded. Conclusion We suggest that MgSO4 is effective in relaxing airway smooth muscle contractions caused by different factors; however, it must be considered that low doses of MgSO4 may only lead to a slight increase in contractions.
authors.affiliation: Department of Anesthesiology and Reanimation, Suleyman Demirel University, School of Medicine,Isparta; Turkey.
authors.forename: Hatice
authors.initials: H
authors.lastname: Betul Altinisik
authors.affiliation: Department of Anesthesiology and Reanimation, Suleyman Demirel University, School of Medicine,Isparta; Turkey.
authors.forename: Pakize
authors.initials: P
authors.lastname: Kirdemir
authors.affiliation: Department of Anesthesiology and Reanimation, Suleyman Demirel University, School of Medicine,Isparta; Turkey.
authors.forename: Ugur
authors.initials: U
authors.lastname: Altinisik
authors.affiliation: Department of Pharmacology; Suleyman Demirel University, School of Medicine, Isparta; Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Gokalp
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D006632:Histamine / Q000494:pharmacology; D008278:Magnesium Sulfate / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects* / Q000502:physiology; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D014132:Trachea / Q000187:drug effects* / Q000502:physiology
chemical_list: D011189:Potassium Chloride; D008278:Magnesium Sulfate; D006632:Histamine; D000109:Acetylcholine
keywords: acetylcholine; histamine; potassium chloride