title: Variables associated with physical health-related quality of life in Parkinson's disease patients presenting for deep brain stimulation.
abstract: Deep brain stimulation (DBS) benefits Parkinson's disease (PD) patient's quality of life specially in domains as mobility, activities of daily living (ADL) and bodily discomfort (BD), but little is known about the variables associated with these HRQOL domains in patients presenting for DBS. The objective is to evaluate variables associated with of HRQOL in a Brazilian sample of PD patients presenting for DBS treatment, specifically in the domains related with motor symptoms. In a cross-sectional study of 59 PD patients evaluated at outpatient Unit for Movement Disorders, multiple linear regression analysis was performed to identify independent variables associated with mobility, ADL and BD domains of the 39-item Parkinson's disease questionnaire (PDQ-39). UPDRS III "on" scores, duration of the disease, age, presence of comorbidities and anxiety and depressive symptoms quantified by hospital anxiety and depression scale (HADS), were the independent variables. In our results, HADS scores were independently associated to mobility domain: β coefficient 1.36 (95 % CI 0.55-2.15) and BD domain: β coefficient 1.57 (95 % CI 0.67-2.48). UPDRS III "on" scores were independently associated to mobility domain: 0.42 (95 % CI 0.03-0.81). The model of each multiple linear regression analysis explains 25 % of the mobility domain variability (p < 0.01) and 24 % of the BD domain variability (p < 0.01). Psychiatric symptoms were at least as relevant to quality of life as motor symptoms in PD patients presenting for DBS treatment. The effect of treating these psychiatric symptoms on patients' HRQOL deserves further investigation.
authors.affiliation: Department of Psychiatry, New York State Psychiatric Institute, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive Unit 24, New York, NY, 10032, USA. alexandrepaimdiaz@gmail.com.|Centro de Ciências da Saúde (CCS), Centro de Neurociências Aplicadas (CeNAp), Hospital Universitário (HU), Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil. alexandrepaimdiaz@gmail.com.|Unidade de Distúrbios do Movimento, Hospital Governador Celso Ramos (HGCR), Florianópolis, SC, Brazil. alexandrepaimdiaz@gmail.com.
authors.forename: Alexandre Paim
authors.initials: AP
authors.lastname: Diaz
authors.affiliation: Centro de Ciências da Saúde (CCS), Centro de Neurociências Aplicadas (CeNAp), Hospital Universitário (HU), Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil.|Unidade de Distúrbios do Movimento, Hospital Governador Celso Ramos (HGCR), Florianópolis, SC, Brazil.
authors.forename: Fernando Cini
authors.initials: FC
authors.lastname: Freitas
authors.affiliation: Centro de Ciências da Saúde (CCS), Centro de Neurociências Aplicadas (CeNAp), Hospital Universitário (HU), Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil.
authors.forename: Maria Emília
authors.initials: ME
authors.lastname: de Oliveira Thais
authors.affiliation: Centro de Ciências da Saúde (CCS), Centro de Neurociências Aplicadas (CeNAp), Hospital Universitário (HU), Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil.
authors.forename: Fernando Zanela
authors.initials: FZ
authors.lastname: da Silva Areas
authors.affiliation: Centro de Ciências da Saúde (CCS), Centro de Neurociências Aplicadas (CeNAp), Hospital Universitário (HU), Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil.|Departamento de Clínica Médica, CCS, HU, UFSC, Florianópolis, SC, Brazil.
authors.forename: Marcelo Liborio
authors.initials: ML
authors.lastname: Schwarzbold
authors.affiliation: Centro de Ciências da Saúde (CCS), Centro de Neurociências Aplicadas (CeNAp), Hospital Universitário (HU), Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Debona
authors.affiliation: Centro de Ciências da Saúde (CCS), Centro de Neurociências Aplicadas (CeNAp), Hospital Universitário (HU), Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil.|Laboratório de Neuropatologia, Serviço de Patologia, HU, UFSC, Florianópolis, Brazil.
authors.forename: Jean Costa
authors.initials: JC
authors.lastname: Nunes
authors.affiliation: Centro de Ciências da Saúde (CCS), Centro de Neurociências Aplicadas (CeNAp), Hospital Universitário (HU), Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Guarnieri
authors.affiliation: Department of Neurology, Center for Movement Disorders and Neurorestoration, University of Florida, 3450 Hull Road, Gainesville, FL, 32607, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Martinez-Ramirez
authors.affiliation: Departamento de Farmacologia, Centro de Ciências Biológicas (CCB), UFSC, Florianópolis, SC, Brazil.
authors.forename: Rui Daniel
authors.initials: RD
authors.lastname: Prediger
authors.affiliation: Department of Neurology, Center for Movement Disorders and Neurorestoration, University of Florida, 3450 Hull Road, Gainesville, FL, 32607, USA.
authors.forename: Aparna
authors.initials: A
authors.lastname: Wagle Shukla
authors.affiliation: Centro de Ciências da Saúde (CCS), Centro de Neurociências Aplicadas (CeNAp), Hospital Universitário (HU), Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil.|Unidade de Distúrbios do Movimento, Hospital Governador Celso Ramos (HGCR), Florianópolis, SC, Brazil.
authors.forename: Marcelo Neves
authors.initials: MN
authors.lastname: Linhares
authors.affiliation: Centro de Ciências da Saúde (CCS), Centro de Neurociências Aplicadas (CeNAp), Hospital Universitário (HU), Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil.|Departamento de Clínica Médica, CCS, HU, UFSC, Florianópolis, SC, Brazil.
authors.forename: Roger
authors.initials: R
authors.lastname: Walz
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D001938:Brazil; D003430:Cross-Sectional Studies; D046690:Deep Brain Stimulation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology* / Q000523:psychology; D011788:Quality of Life
keywords: Deep brain stimulation; Parkinson’s disease; Quality of life