title: Staphylococcus aureus Infection of Human Gestational Membranes Induces Bacterial Biofilm Formation and Host Production of Cytokines.
abstract: Staphylococcus aureus, a metabolically flexible gram-positive pathogen, causes infections in a variety of tissues. Recent evidence implicates S. aureus as an emerging cause of chorioamnionitis and premature rupture of membranes, which are associated with preterm birth and neonatal disease. We demonstrate here that S. aureus infects and forms biofilms on the choriodecidual surface of explanted human gestational membranes. Concomitantly, S. aureus elicits the production of proinflammatory cytokines, which could ultimately perturb maternal-fetal tolerance during pregnancy. Therefore, targeting the immunological response to S. aureus infection during pregnancy could attenuate disease among infected individuals, especially in the context of antibiotic resistance.
authors.affiliation: Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: Ryan S
authors.initials: RS
authors.lastname: Doster
authors.affiliation: Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: Leslie A
authors.initials: LA
authors.lastname: Kirk
authors.affiliation: Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: Lauren M
authors.initials: LM
authors.lastname: Tetz
authors.affiliation: Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Rogers
authors.affiliation: Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: David M
authors.initials: DM
authors.lastname: Aronoff
authors.affiliation: Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.|Department of Veterans Affairs, Tennessee Valley Healthcare Systems, Nashville, TN, USA.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Gaddy
mesh_terms: D018441:Biofilms; D002821:Chorioamnionitis / Q000276:immunology* / Q000382:microbiology; D016207:Cytokines / Q000276:immunology*; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D010920:Placenta / Q000276:immunology / Q000382:microbiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology* / Q000382:microbiology; D047928:Premature Birth / Q000276:immunology / Q000382:microbiology; D013203:Staphylococcal Infections / Q000276:immunology*; D013211:Staphylococcus aureus / Q000276:immunology
chemical_list: D016207:Cytokines
keywords: Staphylococcus aureus; cytokine; gestational membranes