title: High-speed spectral calibration by complex FIR filter in phase-sensitive optical coherence tomography.
abstract: Swept-laser sources offer a number of advantages for Phase-sensitive Optical Coherence Tomography (PhOCT). However, inter- and intra-sweep variability leads to calibration errors that adversely affect phase sensitivity. While there are several approaches to overcoming this problem, our preferred method is to simply calibrate every sweep of the laser. This approach offers high accuracy and phase stability at the expense of a substantial processing burden. In this approach, the Hilbert phase of the interferogram from a reference interferometer provides the instantaneous wavenumber of the laser, but is computationally expensive. Fortunately, the Hilbert transform may be approximated by a Finite Impulse-Response (FIR) filter. Here we explore the use of several FIR filter based Hilbert transforms for calibration, explicitly considering the impact of filter choice on phase sensitivity and OCT image quality. Our results indicate that the complex FIR filter approach is the most robust and accurate among those considered. It provides similar image quality and slightly better phase sensitivity than the traditional FFT-IFFT based Hilbert transform while consuming fewer resources in an FPGA implementation. We also explored utilizing the Hilbert magnitude of the reference interferogram to calculate an ideal window function for spectral amplitude calibration. The ideal window function is designed to carefully control sidelobes on the axial point spread function. We found that after a simple chromatic correction, calculating the window function using the complex FIR filter and the reference interferometer gave similar results to window functions calculated using a mirror sample and the FFT-IFFT Hilbert transform. Hence, the complex FIR filter can enable accurate and high-speed calibration of the magnitude and phase of spectral interferograms.
authors.affiliation: Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843, USA.
authors.forename: Sangmin
authors.initials: S
authors.lastname: Kim
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Stanford University, Stanford, CA, USA.
authors.forename: Patrick D
authors.initials: PD
authors.lastname: Raphael
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Stanford University, Stanford, CA, USA.
authors.forename: John S
authors.initials: JS
authors.lastname: Oghalai
authors.affiliation: Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843, USA.
authors.forename: Brian E
authors.initials: BE
authors.lastname: Applegate
keywords: (110.4500) Optical coherence tomography; (170.4500) Optical coherence tomography