title: Community-Reviewed Biological Network Models for Toxicology and Drug Discovery Applications.
abstract: Biological network models offer a framework for understanding disease by describing the relationships between the mechanisms involved in the regulation of biological processes. Crowdsourcing can efficiently gather feedback from a wide audience with varying expertise. In the Network Verification Challenge, scientists verified and enhanced a set of 46 biological networks relevant to lung and chronic obstructive pulmonary disease. The networks were built using Biological Expression Language and contain detailed information for each node and edge, including supporting evidence from the literature. Network scoring of public transcriptomics data inferred perturbation of a subset of mechanisms and networks that matched the measured outcomes. These results, based on a computable network approach, can be used to identify novel mechanisms activated in disease, quantitatively compare different treatments and time points, and allow for assessment of data with low signal. These networks are periodically verified by the crowd to maintain an up-to-date suite of networks for toxicology and drug discovery applications.
authors.affiliation: Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette, Luxembourg.
authors.forename: Aishwarya Alex
authors.initials: AA
authors.lastname: Namasivayam
authors.affiliation: Pablo de Olavide University, Ctra. de Utrera, Seville, Spain.
authors.forename: Alejandro Ferreiro
authors.initials: AF
authors.lastname: Morales
authors.affiliation: Pablo de Olavide University, Ctra. de Utrera, Seville, Spain.
authors.forename: Ángela María Fajardo
authors.initials: ÁM
authors.lastname: Lacave
authors.affiliation: TWINCORE, Zentrum für Experimentelle und Klinische Infektionsforschung, Hannover, Germany.
authors.forename: Aravind
authors.initials: A
authors.lastname: Tallam
authors.affiliation: FM Pharm, Ltd., Sencanski put bb, Subotica, Serbia.
authors.forename: Borislav
authors.initials: B
authors.lastname: Simovic
authors.affiliation: Pablo de Olavide University, Ctra. de Utrera, Seville, Spain.
authors.forename: David Garrido
authors.initials: DG
authors.lastname: Alfaro
authors.affiliation: Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette, Luxembourg.
authors.forename: Dheeraj Reddy
authors.initials: DR
authors.lastname: Bobbili
authors.affiliation: Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud, Neuchâtel, Switzerland (part of Philip Morris International group of companies).
authors.forename: Florian
authors.initials: F
authors.lastname: Martin
authors.affiliation: Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette, Luxembourg.
authors.forename: Ganna
authors.initials: G
authors.lastname: Androsova
authors.affiliation: Kuban State University of Physical Education, Sport and Tourism, Krasnodar, Russia.
authors.forename: Irina
authors.initials: I
authors.lastname: Shvydchenko
authors.affiliation: Selventa, Alewife Center, Cambridge, MA, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Park
authors.affiliation: Center for Molecular Biology, "Severo Ochoa" - Spanish National Research Council, Madrid, Spain.
authors.forename: Jorge Val
authors.initials: JV
authors.lastname: Calvo
authors.affiliation: Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud, Neuchâtel, Switzerland (part of Philip Morris International group of companies).
authors.forename: Julia
authors.initials: J
authors.lastname: Hoeng
authors.affiliation: Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud, Neuchâtel, Switzerland (part of Philip Morris International group of companies).
authors.forename: Manuel C
authors.initials: MC
authors.lastname: Peitsch
authors.affiliation: Pablo de Olavide University, Ctra. de Utrera, Seville, Spain.
authors.forename: Manuel González Vélez
authors.initials: MG
authors.lastname: Racero
authors.affiliation: Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette, Luxembourg.
authors.forename: Maria
authors.initials: M
authors.lastname: Biryukov
authors.affiliation: Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud, Neuchâtel, Switzerland (part of Philip Morris International group of companies).
authors.forename: Marja
authors.initials: M
authors.lastname: Talikka
authors.affiliation: Pablo de Olavide University, Ctra. de Utrera, Seville, Spain.
authors.forename: Modesto Berraquero
authors.initials: MB
authors.lastname: Pérez
authors.affiliation: Center for Systems Biology, University of Iceland, Reykjavik, Iceland.
authors.forename: Neha
authors.initials: N
authors.lastname: Rohatgi
authors.affiliation: Pablo de Olavide University, Ctra. de Utrera, Seville, Spain.
authors.forename: Noberto
authors.initials: N
authors.lastname: Díaz-Díaz
authors.affiliation: Prakhya Research Laboratories, Lakshminagar, Selaiyur, Chennai, Tamil Nadu, India.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Mandarapu
authors.affiliation: Pablo de Olavide University, Ctra. de Utrera, Seville, Spain.
authors.forename: Rubén Amián
authors.initials: RA
authors.lastname: Ruiz
authors.affiliation: Institute of Biochemical Physics Russian Academy of Sciences, Moscow, Russia.
authors.forename: Sergey
authors.initials: S
authors.lastname: Davidyan
authors.affiliation: Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette, Luxembourg.
authors.forename: Shaman
authors.initials: S
authors.lastname: Narayanasamy
authors.affiliation: Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud, Neuchâtel, Switzerland (part of Philip Morris International group of companies).
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Boué
authors.affiliation: Institute of Bioorganic Chemistry Russian Academy of Sciences, Moscow, Russia.
authors.forename: Svetlana
authors.initials: S
authors.lastname: Guryanova
authors.affiliation: Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette, Luxembourg.
authors.forename: Susana Martínez
authors.initials: SM
authors.lastname: Arbas
authors.affiliation: AnalyzeDat Consulting Services, Edapally Byepass Junction, Kochi, Kerala, India.
authors.forename: Swapna
authors.initials: S
authors.lastname: Menon
authors.affiliation: Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud, Neuchâtel, Switzerland (part of Philip Morris International group of companies).
authors.forename: Yang
authors.initials: Y
authors.lastname: Xiang
keywords: COPD; biological network; crowdsourcing; drug discovery; toxicology