title: [New insights of myositis-specific and -associated autoantibodies in juvenile and adult type myositis].
abstract: Myositis, which means inflammation of the muscles, is a general term used for inflammatory myopathies. Myositis is a rare idiopathic autoimmune disease. It is believed that environmental factors such as virus, bacteria, parasites, direct injuries, drugs side effect can trigger the immune system of genetically susceptible individuals to act against muscle tissues. There are several types of myositis with the same systemic symptoms such as muscle weakness, fatigue, muscle pain and inflammation. These include dermatomyositis, juvenile dermatomyositis, inclusion-body myositis, polymyositis, orbital myositis and myositis ossificans. Juvenile and adult dermatomyositis are chronic, immune-mediated inflammatory myopathies characterized by progressive proximal muscle weakness and typical skin symptoms. The aim of the authors was to compare the symptoms, laboratory and serological findings and disease course in children and adult patients with idiopathic inflammatory myopathy. Early diagnosis and aggressive immunosuppressive treatment improve the mortality of these patients. Myositis-specific autoantibodies have predictive and prognostic values regarding the associated overlap disease, response to treatment and disease course. The authors intend to lighten the clinical and pathogenetic significance of the new target autoantigens. Orv. Hetil., 2016, 157(29), 1179-1184.
authors.affiliation: Népegészségügyi Kar, Fizioterápiás Tanszék, Debreceni Egyetem Debrecen, Kassai u. 27., 4027.
authors.forename: Andrea
authors.initials: A
authors.lastname: Váncsa
authors.affiliation: Általános Orvostudományi Kar, Klinikai Központ, Belgyógyászati Intézet, Klinikai Immunológia Tanszék, Debreceni Egyetem Debrecen.
authors.forename: Katalin
authors.initials: K
authors.lastname: Dankó
mesh_terms: D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000187:drug effects*; D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000276:immunology*; D002648:Child; D002908:Chronic Disease; D003882:Dermatomyositis / Q000175:diagnosis / Q000276:immunology; D018450:Disease Progression; D042241:Early Diagnosis; D005221:Fatigue / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D018908:Muscle Weakness / Q000276:immunology; D009220:Myositis / Q000175:diagnosis* / Q000276:immunology*; D018979:Myositis, Inclusion Body / Q000175:diagnosis / Q000276:immunology; D055622:Orbital Myositis / Q000175:diagnosis / Q000276:immunology; D017285:Polymyositis / Q000175:diagnosis / Q000276:immunology; D011237:Predictive Value of Tests; D011379:Prognosis
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D007166:Immunosuppressive Agents
keywords: clinical immunology; idiopathic inflammatory myopathy; idiopathiás inflammatorikus myopathiák; klinikai immunológia; myositis-specific autoantibodies; myositisspecifikus autoantitestek