title: Mitogen-Activated Protein Kinases and Mitogen Kinase Phosphatase 1: A Critical Interplay in Macrophage Biology.
abstract: Macrophages are necessary in multiple processes during the immune response or inflammation. This review emphasizes the critical role of the mitogen-activated protein kinases (MAPKs) and mitogen kinase phosphatase-1 (MKP-1) in the functional activities of macrophages. While the phosphorylation of MAPKs is required for macrophage activation or proliferation, MKP-1 dephosphorylates these kinases, thus playing a balancing role in the control of macrophage behavior. MKP-1 is a nuclear-localized dual-specificity phosphatase whose expression is regulated at multiple levels, including at the transcriptional and post-transcriptional level. The regulatory role of MKP-1 in the interplay between MAPK phosphorylation/dephosphorylation makes this molecule a critical regulator of macrophage biology and inflammation.
authors.affiliation: Departament of Cell Biology, Physiology and Immunology, Universitat de Barcelona Barcelona, Spain.
authors.forename: Jorge
authors.initials: J
authors.lastname: Lloberas
authors.affiliation: Departament of Cell Biology, Physiology and Immunology, Universitat de Barcelona Barcelona, Spain.
authors.forename: Lorena
authors.initials: L
authors.lastname: Valverde-Estrella
authors.affiliation: Departament of Cell Biology, Physiology and Immunology, Universitat de Barcelona Barcelona, Spain.
authors.forename: Juan
authors.initials: J
authors.lastname: Tur
authors.affiliation: Departament of Cell Biology, Physiology and Immunology, Universitat de Barcelona Barcelona, Spain.
authors.forename: Tania
authors.initials: T
authors.lastname: Vico
authors.affiliation: Departament of Cell Biology, Physiology and Immunology, Universitat de Barcelona Barcelona, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Celada
keywords: immune response; inflammation; kinases; macrophages; phosphatases; signal transduction