title: Histological Evaluation of Nano-Micro Titanium Implant Surface Treatment in Beagle Humerus.
abstract: The objective of this study was to investigate the effects of nano-micro titanium implant surface using histology in beagle dogs. A total of 48 screw-shaped implants (Megagen, Daegu, Korea) which dimensions were 4 mm in diameter and 8.5 mm in length, were used. The implants were classified into 4 groups (n = 12): machined surface (M group), RBM (Resorbable Blasting Media) surface (R group), nano surface which is nanotube formation on the machined surface (MA group) and nano-micro surface which is nanotube formation on the RBM surface (RA group). Anodic oxidation was performed at a constant voltage of 20 V for 10 min using a DC power supply (Fine Power F-3005; SG EMD, Anyang, Korea). The bone blocks were investigated using histology. There was no inflammation around implants, and new bone formation was shown along with the nano-micro titanium implant surfaces. The amount of bone formation was increased depending on time comparing 4 weeks and 12 weeks. At 12 weeks, lamellar bone was more formed along with the nano-micro titanium implant surfaces than 4 weeks. It indicated that nano-micro surface showed good result in terms of osseointegration.
authors.forename: Kwidug
authors.initials: K
authors.lastname: Yun
authors.forename: Seongsoo
authors.initials: S
authors.lastname: Kang
authors.forename: Gyejeong
authors.initials: G
authors.lastname: Oh
authors.forename: Hyunpil
authors.initials: H
authors.lastname: Lim
authors.forename: Kwangmin
authors.initials: K
authors.lastname: Lee
authors.forename: Hongso
authors.initials: H
authors.lastname: Yang
authors.forename: Mongsook
authors.initials: M
authors.lastname: Vang
authors.forename: Sangwon
authors.initials: S
authors.lastname: Park
mesh_terms: D000818:Animals; D001863:Bone Screws; D018786:Bone Substitutes / Q000737:chemistry / Q000494:pharmacology; D004285:Dogs; D006811:Humerus / Q000378:metabolism* / Q000473:pathology; D043942:Nanotubes / Q000737:chemistry*; D016348:Osseointegration / Q000187:drug effects*; D010012:Osteogenesis / Q000187:drug effects*; D014025:Titanium / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D018786:Bone Substitutes; D014025:Titanium