title: The Relationship Between Atherogenic Index and Carotid Artery Atherosclerosis in Familial Mediterranean Fever.
abstract: Familial Mediterranean fever (FMF) is a disease characterized by chronic inflammation. Atherogenic index of plasma (AIP) is a logarithmic value of the triglyceride to high-density lipoprotein cholesterol ratio and it is a good marker for atherosclerotic heart disease and cardiac risk. In this study, we investigated subclinical atherosclerosis and cardiac risks in patients with FMF. Patients with FMF (78 men and 84 women) and healthy controls (74 men and 82 women) were included in this study. The AIP values of the patients were calculated and carotid intima-media thicknesses (cIMTs) were measured. The cIMT ( P < .001) and AIP ( P < .001) values of patients with FMF were higher than the values of the control group. There was a positive correlation between cIMT and AIP values ( r = .304, P < .001). In regression analysis, we detected an independent relationship between cIMT and AIP (β = .248, P = .001). Atherogenic index of plasma may be highly correlated with the subclinical atherosclerosis. Particularly, male patients with FMF may have a high cardiac risk.
authors.affiliation: 1 Department of Cardiology, Necmettin Erbakan University, Konya, Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Icli
authors.affiliation: 2 Department of Internal Medicine, Recep Tayyip Erdogan University, Rize, Turkey.
authors.forename: Erkan
authors.initials: E
authors.lastname: Cure
authors.affiliation: 3 Department of Internal Medicine, Eskisehir Military Hospital, Eskisehir, Turkey.
authors.forename: Ali Ugur
authors.initials: AU
authors.lastname: Uslu
authors.affiliation: 4 Department of Endocrinology and Metabolism, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors.forename: Davut
authors.initials: D
authors.lastname: Sakiz
authors.affiliation: 5 Department of Biochemistry, Recep Tayyip Erdogan University, Rize, Turkey.
authors.forename: Medine Cumhur
authors.initials: MC
authors.lastname: Cure
authors.affiliation: 6 Department of Internal Medicine, Necmettin Erbakan University, Konya, Turkey.
authors.forename: Miyase
authors.initials: M
authors.lastname: Ozucan
authors.affiliation: 7 Department of Physical Medicine and Rehabilitation, Malatya State Hospital, Malatya, Turkey.
authors.forename: Rabia Aydogan
authors.initials: RA
authors.lastname: Baykara
authors.affiliation: 8 Department of Physical Medicine and Rehabilitation, Aksaray State Hospital, Aksaray, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Karakoyun
authors.affiliation: 9 Department of Cardiology, Gulhane Medical Faculty, Ankara, Turkey.
authors.forename: Sevket
authors.initials: S
authors.lastname: Balta
authors.affiliation: 9 Department of Cardiology, Gulhane Medical Faculty, Ankara, Turkey.
authors.forename: Cengiz
authors.initials: C
authors.lastname: Ozturk
authors.affiliation: 10 Division of Allergy and Clinical Immunology, Necmettin Erbakan University, Konya, Turkey.
authors.forename: Sevket
authors.initials: S
authors.lastname: Arslan
authors.affiliation: 11 Division of Rheumatology, Department of Internal Medicine, Malatya State Hospital, Malatya, Turkey.
authors.forename: Adem
authors.initials: A
authors.lastname: Kucuk
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002340:Carotid Artery Diseases / Q000097:blood; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D010505:Familial Mediterranean Fever / Q000097:blood*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D015415:Biomarkers; D008055:Lipids
keywords: atherogenic index of plasma; carotid intima–media thickness; familial Mediterranean fever; subclinical atherosclerosis