title: Cantharimide and Its Derivatives from the Blister Beetle Mylabris phalerata Palla.
abstract: Eleven new monoterpenoids including three 1-methyl cantharimide-type derivatives (1-3), five 1,2-dimethyl cantharimide-type derivatives (4, 5, 7-9), and three 1-hydroxymethyl-2-methyl cantharimide-type derivatives (10-12), together with seven known cantharimides (6, 13-18), were isolated from Mylabis phalerata Palla. The planar structures and absolute configurations of compounds 1-14 were fully elucidated on the basis of spectroscopic analysis, ECD spectra, single-crystal X-ray diffraction analysis, and chemical methods. Compounds 6, 15, 16, and 18 were found to be potent inhibitors of HBV virus, with IC50 values of 62, 42, 58, and 19 μM.
authors.affiliation: Chongqing Academy of Chinese Material Medical , Chongqing, 400065, People's Republic of China.
authors.forename: Yao-Bo
authors.initials: YB
authors.lastname: Zeng
authors.affiliation: Chongqing Academy of Chinese Material Medical , Chongqing, 400065, People's Republic of China.
authors.forename: Xiao-Ling
authors.initials: XL
authors.lastname: Liu
authors.affiliation: Chongqing Academy of Chinese Material Medical , Chongqing, 400065, People's Republic of China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College (State Key Laboratory of Bioactive Substance and Function of Natural Medicines) , Beijing, 100050, People's Republic of China.
authors.forename: Chuang-Jun
authors.initials: CJ
authors.lastname: Li
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College (State Key Laboratory of Bioactive Substance and Function of Natural Medicines) , Beijing, 100050, People's Republic of China.
authors.forename: Dong-Ming
authors.initials: DM
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Sciences, Southwest University , Chongqing, 400715, People's Republic of China.
authors.forename: Yao-Zong
authors.initials: YZ
authors.lastname: Peng
authors.affiliation: Chongqing Academy of Chinese Material Medical , Chongqing, 400065, People's Republic of China.
authors.forename: Xing
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Chongqing Academy of Chinese Material Medical , Chongqing, 400065, People's Republic of China.
authors.forename: Hong-Fei
authors.initials: HF
authors.lastname: Du
authors.affiliation: Chongqing Academy of Chinese Material Medical , Chongqing, 400065, People's Republic of China.
authors.forename: Chun-Bing
authors.initials: CB
authors.lastname: Tan
authors.affiliation: Chongqing Academy of Chinese Material Medical , Chongqing, 400065, People's Republic of China.
authors.forename: Yu-Yu
authors.initials: YY
authors.lastname: Zhang
authors.affiliation: Chongqing Academy of Chinese Material Medical , Chongqing, 400065, People's Republic of China.
authors.forename: Da-Jian
authors.initials: DJ
authors.lastname: Yang
mesh_terms: D000818:Animals; D002681:China; D001517:Coleoptera / Q000737:chemistry*; D018360:Crystallography, X-Ray; D020128:Inhibitory Concentration 50; D008968:Molecular Conformation; D015394:Molecular Structure; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D039821:Monoterpenes