title: Combination of cisplatin and lurbinectedin as palliative chemotherapy in progressive malignant pleural mesothelioma: Report of two cases.
abstract: Malignant mesothelioma is an aggressive disease with dismal prognosis despite multimodal treatment including chemotherapy, surgery and radiotherapy. At progression it is possible to provide systemic second-line treatment but its effects are limited. Herein we report two patient cases with mesothelioma who received second-line chemotherapy with the combination of cisplatin and the novel compound lurbinectedin. The combination showed promising activity in both cases with manageable toxicity. We discuss the results of this regime in the light of historical as well as emerging data in mesothelioma.
authors.affiliation: Department of Oncology, Kantonsspital Graubünden, Loestrasse 170, 7000, Chur, Switzerland. Electronic address: ioannis.metaxas@ksgr.ch.
authors.forename: Yannis
authors.initials: Y
authors.lastname: Metaxas
authors.affiliation: Department of Oncology, Kantonsspital Graubünden, Loestrasse 170, 7000, Chur, Switzerland.
authors.forename: Richard
authors.initials: R
authors.lastname: Cathomas
authors.affiliation: Department of Oncology, Kantonsspital Graubünden, Loestrasse 170, 7000, Chur, Switzerland.
authors.forename: Michael
authors.initials: M
authors.lastname: Mark
authors.affiliation: Department of Oncology, Kantonsspital Graubünden, Loestrasse 170, 7000, Chur, Switzerland.
authors.forename: Roger
authors.initials: R
authors.lastname: von Moos
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002243:Carbolines / Q000008:administration & dosage / Q000009:adverse effects; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D017321:Clinical Trials, Phase I as Topic; D003131:Combined Modality Therapy; D006576:Heterocyclic Compounds, 4 or More Rings / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery; D008297:Male; D008654:Mesothelioma / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery; D000086002:Mesothelioma, Malignant; D010166:Palliative Care / Q000379:methods*; D010997:Pleural Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery; D011379:Prognosis
chemical_list: D002243:Carbolines; D006576:Heterocyclic Compounds, 4 or More Rings; C568606:PM 01183; D002945:Cisplatin
keywords: Lurbinectedin; Mesothelioma; Palliative chemotherapy