title: Progression of Macular Atrophy in Pattern Dystrophies.
abstract: To quantify the progression of macular atrophy associated with pattern dystrophies (PD).
  
  
  
  Retrospective, observational study including patients with reticular PD and macular atrophy. A detailed ophthalmologic exam was performed, and progression of macular atrophy areas was evaluated on fundus autofluorescence frames using RegionFinder software, a semiautomated software embedded in Spectralis device (Heidelberg Engineering, Heidelberg, Germany).
  
  
  
  We included 19 eyes of 12 patients. The median follow-up was 4.5 years (interquartile range [IQR]: 2.7-5.5). Three eyes (16%) had choroidal neovascularization. Atrophy involved foveal area in 21% (four of 19) of cases. Decreased vision occurred in three eyes (16%). The median atrophy progression rate evaluated by RegionFinder software was 0.101 mm(2)/year (IQR: 0.054-0.257).
  
  
  
  The progression of macular atrophy in PDs appears to be relatively slow. Further studies are necessary to correlate the progression of atrophy in PDs with genetic data. [Ophthalmic Surg Lasers Imaging Retina. 2016;47:652-658.].
authors.forename: Céline Mebsout
authors.initials: CM
authors.lastname: Pallado
authors.forename: Anne
authors.initials: A
authors.lastname: Sikorav
authors.forename: Oudy
authors.initials: O
authors.lastname: Semoun
authors.forename: Camille
authors.initials: C
authors.lastname: Jung
authors.forename: Eric H
authors.initials: EH
authors.lastname: Souied
mesh_terms: D000368:Aged; D001284:Atrophy / Q000175:diagnosis; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005584:Fovea Centralis / Q000473:pathology*; D005654:Fundus Oculi; D006801:Humans; D008268:Macular Degeneration / Q000175:diagnosis*; D008297:Male; D009887:Ophthalmoscopy; D055213:Retinal Pigment Epithelium / Q000473:pathology*; D012189:Retrospective Studies; D013997:Time Factors; D041623:Tomography, Optical Coherence