title: Secondary consent to biospecimen use in a prostate cancer biorepository.
abstract: BACKGROUND
  Biorepository research has substantial societal benefits. This is one of the few studies to focus on male willingness to allow future research use of biospecimens.
  
  
  METHODS
  This study analyzed the future research consent questions from a prostate cancer biorepository study (N = 1931). The consent form asked two questions regarding use of samples in future studies (1) without and (2) with protected health information (PHI). Yes to both questions of use of samples was categorized as Yes-Always; Yes to without and No to with PHI was categorized as Yes-Conditional; No to without PHI was categorized as Never. We analyzed this outcome to determine significant predictors for consent to Yes-Always vs. Yes-Conditional.
  
  
  RESULTS
  99.33 % consented to future use of samples; 88.19 % consented to future use without PHI, and among those men 10.2 % consented to future use with PHI. Comparing Yes Always and Yes Conditional responses, bivariate analyses showed that race, family history, stage of cancer, and grade of cancer (Gleason), were significant at the α = 0.05 level. Using stepwise multivariable logistic regression, we found that African-American men were significantly more likely to respond Yes Always when compared to White men (p < 0.001). Those with a family history of prostate cancer were significantly more likely to respond Yes Always (p = 0.002).
  
  
  CONCLUSIONS
  There is general willingness to consent to future use of specimens without PHI among men.
authors.affiliation: Division of Public Health Sciences, Washington University School of Medicine, 600 S. Taylor Ave, Campus Box 8100, St. Louis, MO, 63110, USA. drakeb@wustl.edu.|Alvin J. Siteman Cancer Center, St. Louis, MO, USA. drakeb@wustl.edu.
authors.forename: Bettina F
authors.identifier: http://orcid.org/0000-0001-9340-5848
authors.initials: BF
authors.lastname: Drake
authors.affiliation: Division of Public Health Sciences, Washington University School of Medicine, 600 S. Taylor Ave, Campus Box 8100, St. Louis, MO, 63110, USA.
authors.forename: Katherine
authors.initials: K
authors.lastname: Brown
authors.affiliation: Vanderbilt University, Nashville, TN, USA.
authors.forename: Lucy D'Agostino
authors.initials: LD
authors.lastname: McGowan
authors.affiliation: University of Missouri School of Medicine, Columbia, MO, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Haslag-Minoff
authors.affiliation: Department of Communication, University of Utah, Salt Lake City, UT, USA.|Huntsman Cancer Institute, Salt Lake City, UT, USA.
authors.forename: Kimberly
authors.initials: K
authors.lastname: Kaphingst
mesh_terms: D000368:Aged; D044383:Black People; D066275:Health Information Exchange / Q000941:ethics / Q000706:statistics & numerical data*; D055991:Health Records, Personal / Q000941:ethics / Q000523:psychology*; D006801:Humans; D007258:Informed Consent / Q000941:ethics / Q000523:psychology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011467:Prostate / Q000473:pathology / Q000601:surgery; D011471:Prostatic Neoplasms / Q000208:ethnology / Q000473:pathology / Q000523:psychology* / Q000601:surgery; D011795:Surveys and Questionnaires; D014015:Tissue Banks / Q000941:ethics; D044465:White People; D001741:Black or African American
keywords: African–American; Biorepository; Consent; Prostate cancer; Protected health information