title: Cobalt-Catalyzed C-H Thiolation through Dehydrogenative Cross-Coupling.
abstract: A cobalt-catalyzed dehydrogenative cross-coupling of thiols and indoles is reported. Using a cooperative reaction system, a new mode of action for the cobalt-catalyzed C-heteroatom bond formation was found. The directed C-H activation catalysis overrides an undirected thiolation of indole in the 3-position that occurs in the absence of cobalt. Mechanistic studies indicate a sequence of C-H activation, thiolate transfer, and reductive elimination.
authors.affiliation: Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149, Münster, Germany.
authors.forename: Tobias
authors.initials: T
authors.lastname: Gensch
authors.affiliation: Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149, Münster, Germany.
authors.forename: Felix J R
authors.initials: FJ
authors.lastname: Klauck
authors.affiliation: Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149, Münster, Germany. glorius@uni-muenster.de.
authors.forename: Frank
authors.identifier: 0000-0002-0648-956X
authors.initials: F
authors.lastname: Glorius
keywords: C−H activation; C−heteroatom coupling; cobalt; cross-coupling; thiolation