title: Global Efforts in the Development of Vaccines for Tuberculosis: Requirements for Improved Vaccines Against Mycobacterium tuberculosis.
abstract: Currently, more than 9.0 million people develop acute pulmonary tuberculosis (TB) each year and about 1.5 million people worldwide die from this infection. Thus, developing vaccines to prevent active TB disease remains a priority. This article discusses recent progress in the development of new vaccines against TB and focusses on the main requirements for development of improved vaccines against Mycobacterium tuberculosis (M. tb). Over the last two decades, significant progress has been made in TB vaccine development, and some TB vaccine candidates have currently completed a phase III clinical trial. The potential public health benefits of these vaccines are possible, but it will need much more effort, including new global governance investment on this research. This investment would certainly be less than the annual global financial toll of TB treatment.
authors.affiliation: Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, IPN, CD México, México. pmendezsamperio@gmail.com.
authors.forename: P
authors.initials: P
authors.lastname: Méndez-Samperio
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000382:microbiology; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000382:microbiology; D017326:Clinical Trials, Phase III as Topic; D016207:Cytokines / Q000096:biosynthesis / Q000276:immunology; D014943:Global Health; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D056724:Immunity, Humoral / Q000187:drug effects; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects / Q000276:immunology / Q000382:microbiology; D032581:Tuberculosis Vaccines / Q000008:administration & dosage* / Q000096:biosynthesis / Q000138:chemical synthesis; D014397:Tuberculosis, Pulmonary / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D014611:Vaccination; D014613:Vaccines, Attenuated; D022223:Vaccines, Subunit
chemical_list: D016207:Cytokines; D032581:Tuberculosis Vaccines; D014613:Vaccines, Attenuated; D022223:Vaccines, Subunit