title: Observed Patterns of Systemic Disease on PET/CT Scan in Patients with Presumed Ocular Tuberculosis: Findings and Hypotheses.
abstract: OBJECTIVE
  To report the clinical, investigational and PET/CT scan findings of patients with presumed ocular tuberculosis and suggest a hypotheses for the pathogenesis.
  
  
  METHODS
  Retrospective case review. Included were 10 males and 17 females with an age range: 23-71 years.
  
  
  RESULTS
  Clinical findings include granulomatous or non-granulomatous anterior uveitis, intermediate uveitis, panuveitis, vasculitis, and multifocal serpiginous-like choroidopathy. A total of 13 PET/CT scans were normal and 14 showed systemic disease. The commonest finding was metabolically active lymphadenopathy and was seen in 14 patients. Mediastinal lymphadenitis was seen in 12 patients, 3 patients had abdominal/pelvic lymphadenopathy and 3 patients had additional cervical lymphadenopathy. Two patients had only cervical lymphadenitis. One patient had lung parenchymal disease and one had bone/joint disease. The commonest pathology was lymphadenitis.
  
  
  CONCLUSIONS
  Uveitis is part of an immune response to mycobacteria that manifests as lymphadenitis in the chest/abdomen and as a uveitis.
authors.affiliation: a Department of Ophthalmology , Lilavati Hospital and Research Center , Mumbai , India.
authors.forename: Salil
authors.identifier: http://orcid.org/0000-0003-4175-459X
authors.initials: S
authors.lastname: Mehta
mesh_terms: D000328:Adult; D000368:Aged; D015862:Choroid Diseases / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008198:Lymph Nodes; D008297:Male; D008482:Mediastinum; D008875:Middle Aged; D049268:Positron-Emission Tomography; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D014388:Tuberculosis, Lymph Node / Q000000981:diagnostic imaging*; D014392:Tuberculosis, Ocular / Q000000981:diagnostic imaging*; D014605:Uveitis / Q000000981:diagnostic imaging*; D014657:Vasculitis / Q000000981:diagnostic imaging*; D055815:Young Adult