title: Brain tumor imaging of rat fresh tissue using terahertz spectroscopy.
abstract: Tumor imaging by terahertz spectroscopy of fresh tissue without dye is demonstrated using samples from a rat glioma model. The complex refractive index spectrum obtained by a reflection terahertz time-domain spectroscopy system can discriminate between normal and tumor tissues. Both the refractive index and absorption coefficient of tumor tissues are higher than those of normal tissues and can be attributed to the higher cell density and water content of the tumor region. The results of this study indicate that terahertz technology is useful for detecting brain tumor tissue.
authors.affiliation: R&D Headquarters, Canon Inc., 3-30-2 Shimomaruko, Ohta-ku, Tokyo 146-8501, Japan.
authors.forename: Sayuri
authors.initials: S
authors.lastname: Yamaguchi
authors.affiliation: Medical Photonics Research Center, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu City, Shizuoka 431-3192, Japan.
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Fukushi
authors.affiliation: R&D Headquarters, Canon Inc., 3-30-2 Shimomaruko, Ohta-ku, Tokyo 146-8501, Japan.
authors.forename: Oichi
authors.initials: O
authors.lastname: Kubota
authors.affiliation: R&D Headquarters, Canon Inc., 3-30-2 Shimomaruko, Ohta-ku, Tokyo 146-8501, Japan.
authors.forename: Takeaki
authors.initials: T
authors.lastname: Itsuji
authors.affiliation: R&D Headquarters, Canon Inc., 3-30-2 Shimomaruko, Ohta-ku, Tokyo 146-8501, Japan.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Ouchi
authors.affiliation: Medical Photonics Research Center, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu City, Shizuoka 431-3192, Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Yamamoto
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000000981:diagnostic imaging*; D005910:Glioma / Q000000981:diagnostic imaging*; D051381:Rats; D055068:Terahertz Spectroscopy / Q000379:methods*