title: Recent advances of liquid chromatography-(tandem) mass spectrometry in clinical and forensic toxicology - An update.
abstract: Liquid chromatography (LC) coupled to mass spectrometry (MS) or tandem mass spectrometry (MS/MS) is a well-established and widely used technique in clinical and forensic toxicology as well as doping control especially for quantitative analysis. In recent years, many applications for so-called multi-target screening and/or quantification of drugs, poisons, and or their metabolites in biological matrices have been developed. Such methods have proven particularly useful for analysis of so-called new psychoactive substances that have appeared on recreational drug markets throughout the world. Moreover, the evolvement of high resolution MS techniques and the development of data-independent detection modes have opened new possibilities for applications of LC-(MS/MS) in systematic toxicological screening analysis in the so called general unknown setting. The present paper will provide an overview and discuss these recent developments focusing on the literature published after 2010.
authors.affiliation: University Hospital Jena, Institute of Forensic Medicine, Fürstengraben 23, D-07743 Jena, Germany.
authors.forename: Daniela
authors.initials: D
authors.lastname: Remane
authors.affiliation: University Hospital Jena, Institute of Forensic Medicine, Fürstengraben 23, D-07743 Jena, Germany.
authors.forename: Dirk K
authors.initials: DK
authors.lastname: Wissenbach
authors.affiliation: University Hospital Jena, Institute of Forensic Medicine, Fürstengraben 23, D-07743 Jena, Germany. Electronic address: frank.peters@med.uni-jena.de.
authors.forename: Frank T
authors.initials: FT
authors.lastname: Peters
mesh_terms: D002853:Chromatography, Liquid / Q000379:methods*; D053593:Forensic Toxicology; D006801:Humans; D011619:Psychotropic Drugs / Q000032:analysis; D053719:Tandem Mass Spectrometry / Q000379:methods*
chemical_list: D011619:Psychotropic Drugs
keywords: Doping; Identification; Liquid chromatography; Mass spectrometry; Matrix effect; Quantification; Screening; Toxicology