title: The potential of miRNAs for diagnosis, treatment and monitoring of breast cancer.
abstract: Dysregulation of microRNAs (miRNAs) has a fundamental role in the initiation, development and progression of several human cancers, including breast cancer (BC), since strong evidence has shown that miRNAs can regulate the expression of oncogenes or tumor suppressor genes. A possible role of miRNAs in the diagnosis in BC has been demonstrated. As miRNAs has been found stable in biofluids, extracellular multiple miRNA profiles have been proposed as diagnostic tools, showing better diagnostic performance than individual miRNAs in BC. In this paper, based on the current literature, we present the role of microRNAs in the diagnosis and therapy monitoring of BC. Furthermore, we report new miRNA-based drugs that could be turned into promising therapy for BC, alone or in combination with conventional therapy. We also discuss how extracellular miRNAs could become new, easily accessible, affordable, non-invasive tools for BC patients.
authors.affiliation: a Institute of Molecular Bioimaging and Physiology, National Research Council (IBFM-CNR) , Segrate ( MI ), Italy.
authors.forename: Gloria
authors.initials: G
authors.lastname: Bertoli
authors.affiliation: a Institute of Molecular Bioimaging and Physiology, National Research Council (IBFM-CNR) , Segrate ( MI ), Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Cava
authors.affiliation: a Institute of Molecular Bioimaging and Physiology, National Research Council (IBFM-CNR) , Segrate ( MI ), Italy.
authors.forename: Isabella
authors.initials: I
authors.lastname: Castiglioni
mesh_terms: D000070416:Antagomirs / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D006801:Humans; D035683:MicroRNAs / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism; D058990:Molecular Targeted Therapy; D009367:Neoplasm Staging; D009857:Oncogenes; D011379:Prognosis; D059467:Transcriptome; D016896:Treatment Outcome
chemical_list: D000070416:Antagomirs; D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D035683:MicroRNAs
keywords: Biomarkers; breast cancer; microRNA/miRNAs