title: The Effects of Different Aspirin Dosing Frequencies and the Timing of Aspirin Intake in Primary and Secondary Prevention of Cardiovascular Disease: A Systematic Review.
abstract: Enhancing the effectiveness of aspirin by tailoring administration regimens is an important question among health professionals. We conducted a systematic review to evaluate the evidence on the effects of different aspirin regimens in terms of timing (chronotherapy) or frequency of dosing in the prevention of cardiovascular disease. Only two out of the 28 included studies reported long-term cardiovascular outcomes, highlighting an evidence gap that future research should address. The remaining 26 studies used surrogate outcomes.
authors.affiliation: Institute of Applied Health Research, College of Medical & Dental Sciences, University of Birmingham, Edgbaston, Birmingham, UK.
authors.forename: D
authors.initials: D
authors.lastname: Bem
authors.affiliation: Montreal Heart Institute, Research Centre, Montréal, QC, Canada.|Université de Montreal, Faculté de pharmacie, Montreal, QC, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Lordkipanidzé
authors.affiliation: Institute of Applied Health Research, College of Medical & Dental Sciences, University of Birmingham, Edgbaston, Birmingham, UK.
authors.forename: J
authors.initials: J
authors.lastname: Hodgkinson
authors.affiliation: Institute of Applied Health Research, College of Medical & Dental Sciences, University of Birmingham, Edgbaston, Birmingham, UK.
authors.forename: S
authors.initials: S
authors.lastname: Stevens
authors.affiliation: Institute of Applied Health Research, College of Medical & Dental Sciences, University of Birmingham, Edgbaston, Birmingham, UK.
authors.forename: S
authors.initials: S
authors.lastname: Bayliss
authors.affiliation: Institute of Applied Health Research, College of Medical & Dental Sciences, University of Birmingham, Edgbaston, Birmingham, UK.
authors.forename: D
authors.initials: D
authors.lastname: Moore
authors.affiliation: Institute of Applied Health Research, College of Medical & Dental Sciences, University of Birmingham, Edgbaston, Birmingham, UK. D.A.Fitzmaurice@bham.ac.uk.
authors.forename: D
authors.initials: D
authors.lastname: Fitzmaurice
authors.affiliation: Institute of Applied Health Research, College of Medical & Dental Sciences, University of Birmingham, Edgbaston, Birmingham, UK. j.dretzke@bham.ac.uk.
authors.forename: J
authors.initials: J
authors.lastname: Dretzke
mesh_terms: D001241:Aspirin / Q000008:administration & dosage*; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D004334:Drug Administration Schedule; D055870:Drug Chronotherapy; D006801:Humans; D011322:Primary Prevention / Q000379:methods*; D055502:Secondary Prevention / Q000379:methods*
chemical_list: D001241:Aspirin