title: Frequent co-expression of EGFR and NeuGcGM3 ganglioside in cancer: it's potential therapeutic implications.
abstract: Interaction between epidermal growth factor receptor (EGFR) signaling with GM3 ganglioside expression has been previously described. However, little is known about EGFR and NeuGcGM3 co-expression in cancer patients and their therapeutic implications. In this paper, we evaluate the co-expression of EGFR and NeuGcGM3 ganglioside in tumors from 92 patients and in two spontaneous lung metastasis models of mice (Lewis lung carcinoma (3LL-D122) in C57BL/6 and mammary carcinoma (4T1) in BALB/c). As results, co-expression of EGFR and NeuGcGM3 ganglioside was frequently observed in 63 of 92 patients (68 %), independently of histological subtype. Moreover, EGFR is co-expressed with NeuGcGM3 ganglioside in the metastasis of 3LL-D122 and 4T1 murine models. Such dual expression appears to be therapeutically relevant, since combined therapy with mAbs against these two molecules synergistically increase the survival of mice treated. Overall, our results suggest that NeuGcGM3 and EGFR may coordinately contribute to the tumor cell biology and that therapeutic combinations against these two targets might be a valid strategy to explore.
authors.affiliation: Center of Molecular Immunology (CIM), 216 Street and 15 Avenue, Atabey, Playa, P.O. Box 16040, Habana, Cuba. addys@cim.sld.cu.
authors.forename: Addys González
authors.initials: AG
authors.lastname: Palomo
authors.affiliation: Center of Molecular Immunology (CIM), 216 Street and 15 Avenue, Atabey, Playa, P.O. Box 16040, Habana, Cuba.
authors.forename: Rancés Blanco
authors.initials: RB
authors.lastname: Santana
authors.affiliation: Department of Cell Biology and Tissues Banking, National Institute of Oncology and Radiology, 29 and F Street, Vedado, Plaza de la Revolución, P.O. Box 10400, Havana, Cuba.
authors.forename: Xiomara Escobar
authors.initials: XE
authors.lastname: Pérez
authors.affiliation: Department of Cell Biology and Tissues Banking, National Institute of Oncology and Radiology, 29 and F Street, Vedado, Plaza de la Revolución, P.O. Box 10400, Havana, Cuba.
authors.forename: Damián Blanco
authors.initials: DB
authors.lastname: Santana
authors.affiliation: Laboratory of Molecular Oncology, Quilmes National University, R. Sáenz Peña 180, P.O. Box B1876BXD, Buenos Aires, Argentina.
authors.forename: Mariano Rolando
authors.initials: MR
authors.lastname: Gabri
authors.affiliation: Center of Molecular Immunology (CIM), 216 Street and 15 Avenue, Atabey, Playa, P.O. Box 16040, Habana, Cuba.
authors.forename: Kalet León
authors.initials: KL
authors.lastname: Monzon
authors.affiliation: Center of Molecular Immunology (CIM), 216 Street and 15 Avenue, Atabey, Playa, P.O. Box 16040, Habana, Cuba.
authors.forename: Adriana Carr
authors.initials: AC
authors.lastname: Pérez
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D066246:ErbB Receptors / Q000096:biosynthesis / Q000235:genetics*; D005260:Female; D005679:G(M3) Ganglioside / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D015674:Mammary Neoplasms, Animal / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D051379:Mice; D009362:Neoplasm Metastasis
chemical_list: D000911:Antibodies, Monoclonal; D005679:G(M3) Ganglioside; C044298:N-glycolylneuraminyllactosylceramide; C541485:EGFR protein, mouse; D066246:ErbB Receptors
keywords: Co-expression; Combination therapy; EGFR, NeuGcGM3; Pulmonary metastasis