title: Micronuclei as a marker for medical screening of subjects continuously occupationally exposed to low doses of ionizing radiation.
abstract: BACKGROUND
  Genotoxicity assays are widely employed in human biomonitoring studies to assess genetic damage inflicted by genotoxic agents.
  
  
  OBJECTIVE
  Evaluation of micronuclei (MN) as a screening marker of occupational ionizing radiation (IR) exposure.
  
  
  METHODS
  Using micronucleus test, peripheral blood lymphocytes (PBL) of 402 control and exposed subjects were screened for genetic damage.
  
  
  RESULTS
  The mean frequencies of micronucleus test parameters were significantly higher in exposed persons. Increase of micronucleus yield with duration of exposure (DOE) by 0.303MN/year was revealed.
  
  
  CONCLUSIONS
  The obtained data encourage us to consider MN as valuable markers for preventive medical screening of occupationally exposed groups.
authors.affiliation: a Serbian Institute of Occupational Health "Dr Dragomir Karajovic" , Belgrade , Serbia.
authors.forename: Jelena
authors.initials: J
authors.lastname: Pajic
authors.affiliation: b Genotoxicology Department, Faculty of Applied Ecology "Futura" , University "Singidunum" , Belgrade , Serbia.
authors.forename: Dubravka
authors.initials: D
authors.lastname: Jovicic
authors.affiliation: a Serbian Institute of Occupational Health "Dr Dragomir Karajovic" , Belgrade , Serbia.|c Occupational Health Department, Faculty of Medicine , University of Belgrade , Belgrade , Serbia.
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Ps Milovanovic
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis* / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000737:chemistry; D008297:Male; D008403:Mass Screening / Q000379:methods; D015162:Micronucleus Tests / Q000379:methods*; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D011839:Radiation, Ionizing; D055771:Serbia / Q000453:epidemiology
chemical_list: D015415:Biomarkers
keywords: Micronuclei; biomarkers; low-dose ionizing radiation; medical screening; occupational exposure