title: A systematic review and meta-analysis of MDM2 polymorphisms in osteosarcoma susceptibility.
abstract: Two polymorphisms in the murine double minute 2 (MDM2) gene (rs1690916 and rs2279744) have been associated with the risk of osteosarcoma (OS). When we analyzed these two polymorphisms in two new independents cohorts (Spanish and Slovenian), we found no association. In order to clarify this, we conducted a meta-analysis including six populations, with a total of 246 OS patients and 1,760 controls for rs1690916; and 433 OS patients and 1,959 controls for rs2279744. Pooled odds ratio risks and corresponding 95% CI were estimated to assess the possible associations. Our results showed that these two polymorphisms were not associated with the susceptibility of OS under any genetic model studied. In conclusion, the present meta-analysis indicates that MDM2 rs1690916 and rs2279744 cannot be considered as genetic risk factors for OS susceptibility in the different populations. Therefore, the influence of these two polymorphisms on the risk of OS may be less important than previously suggested. Future studies are needed to confirm these results.
authors.affiliation: Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Medicine and Odontology, University of the Basque Country, UPV/EHU, Spain.
authors.forename: Nerea
authors.initials: N
authors.lastname: Bilbao-Aldaiturriaga
authors.affiliation: Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Medicine and Odontology, University of the Basque Country, UPV/EHU, Spain.
authors.forename: Ziortza
authors.initials: Z
authors.lastname: Askaiturrieta
authors.affiliation: Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Medicine and Odontology, University of the Basque Country, UPV/EHU, Spain.
authors.forename: Itsasne
authors.initials: I
authors.lastname: Granado-Tajada
authors.affiliation: Institute of Biochemistry, Faculty of Medicine, Ljubljana, Slovenia.
authors.forename: Katja
authors.initials: K
authors.lastname: Goričar
authors.affiliation: Institute of Biochemistry, Faculty of Medicine, Ljubljana, Slovenia.
authors.forename: Vita
authors.initials: V
authors.lastname: Dolžan
authors.lastname: For The Slovenian Osteosarcoma Study Group
authors.affiliation: Service of Pediatric Oncohematology, University Hospital La Paz, Madrid, Spain.
authors.forename: Purificación
authors.initials: P
authors.lastname: Garcia-Miguel
authors.affiliation: Unit of Pediatric Oncohematology, University Hospital Donostia, San Sebastián, Spain.
authors.forename: Nagore
authors.initials: N
authors.lastname: Garcia de Andoin
authors.affiliation: Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Medicine and Odontology, University of the Basque Country, UPV/EHU, Spain.
authors.forename: Idoia
authors.initials: I
authors.lastname: Martin-Guerrero
authors.affiliation: Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Medicine and Odontology, University of the Basque Country, UPV/EHU, Spain.|BioCruces Health Research Institute, Barakaldo, Spain.
authors.forename: Africa
authors.initials: A
authors.lastname: Garcia-Orad
mesh_terms: D020413:3' Untranslated Regions; D000483:Alleles; D015331:Cohort Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015337:Multicenter Studies as Topic; D016017:Odds Ratio; D012516:Osteosarcoma / Q000235:genetics*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics*; D012307:Risk Factors; D017524:Slovenia; D013030:Spain
chemical_list: D020413:3' Untranslated Regions; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2