title: Influence of cardiorespiratory fitness and physical activity levels on cardiometabolic risk factors during menopause transition: A MONET study.
abstract: To determine the influence of cardiorespiratory fitness (hereafter "fitness") and physical activity levels on cardiometabolic risk factors in premenopausal women going through the menopause transition. An ancillary study including 66 premenopausal women who participated to a 5-year observational, longitudinal study (2004 to 2009 in Ottawa) on the effects of menopause transition on body composition and cardiometabolic risk factors. Women underwent a graded exercise test on treadmill to measure peak oxygen uptake (VO2 peak) at year 1 and 5 and physical activity levels were measured using accelerometers. Cardiometabolic risk factors included: waist circumference, fasting plasma lipids, glucose and insulin levels, HOMA-IR score, c-reactive protein, apolipoprotein B (apoB) and resting systolic and diastolic blood pressure. Change in fitness was not associated with changes in cardiometabolic risk factors. The changes in total physical activity levels on the other hand showed a significant negative association with apoB levels. Three-way linear mixed model repeated measures, showed lower values of waist circumference, fasting triglycerides, insulin levels, HOMA-IR score, apoB and diastolic blood pressure in women with a fitness ≥ 30.0 mlO2 kg(- 1) min(- 1) compared to women with a fitness < 30.0 mlO2 kg(- 1) min(- 1) (P < 0.05). However, only fasting triglycerides was lower in women with physical activity levels ≥ 770.0 Kcal/day (P < 0.05). Between fitness and physical activity levels, fitness was associated with more favorable values of cardiometabolic risk factors in women followed for 5 years during the menopause transition.
authors.affiliation: School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada; Institut de recherche de l'Hôpital Montfort, Ottawa, ON, Canada; Behavioral and Metabolic Research Unit, University of Ottawa, Ottawa, ON, Canada.
authors.forename: Joseph
authors.initials: J
authors.lastname: Abdulnour
authors.affiliation: School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada; Institut de recherche de l'Hôpital Montfort, Ottawa, ON, Canada; Behavioral and Metabolic Research Unit, University of Ottawa, Ottawa, ON, Canada.
authors.forename: Sahar
authors.initials: S
authors.lastname: Razmjou
authors.affiliation: School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada; Behavioral and Metabolic Research Unit, University of Ottawa, Ottawa, ON, Canada.
authors.forename: Éric
authors.initials: É
authors.lastname: Doucet
authors.affiliation: Université de Sherbrooke, Faculté des sciences de l'activité physique, Sherbrooke, QC, Canada; Research Centre on Aging, Social Services and Health Centre-University Institute of Geriatrics of Sherbrooke, PQ, Canada.
authors.forename: Pierre
authors.initials: P
authors.lastname: Boulay
authors.affiliation: Université de Sherbrooke, Faculté des sciences de l'activité physique, Sherbrooke, QC, Canada; Research Centre on Aging, Social Services and Health Centre-University Institute of Geriatrics of Sherbrooke, PQ, Canada.
authors.forename: Martin
authors.initials: M
authors.lastname: Brochu
authors.affiliation: Department of Nutrition, Université de Montréal, Montreal, PQ, Canada; Montréal Diabetes Research Centre, Montréal, PQ, Canada; Institut de Recherche Cliniques de Montréal, Montreal, PQ, Canada.
authors.forename: Rémi
authors.initials: R
authors.lastname: Rabasa-Lhoret
authors.affiliation: Department of Kinesiology, Université de Montréal, Montréal, PQ, Canada.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Lavoie
authors.affiliation: School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada; Institut de recherche de l'Hôpital Montfort, Ottawa, ON, Canada.
authors.forename: Denis
authors.initials: D
authors.lastname: Prud'homme
keywords: Cardiometabolic risk factors; Cardiorespiratory fitness; Fitness; Menopause; Physical activity