title: The effects of resveratrol intervention on risk markers of cardiovascular health in overweight and obese subjects: a pooled analysis of randomized controlled trials.
abstract: Potential effects of resveratrol consumption on cardiovascular disease risk factors and body weight in overweight/obese adults have not been fully elucidated. Our present analysis was to evaluate the effects of resveratrol consumption on risk markers related to cardiovascular health in overweight/obese Individuals.
  
  
  
  Multiple literature databases were systematically searched, and 21 studies were included. Effect sizes were expressed as weighted mean difference (WMD) and 95% confidence interval (CI), and heterogeneity was assessed with the I2 test. Publication bias and subgroup analyses were also performed.
  
  
  
  There were variations in reporting quality of included studies. Resveratrol intervention significantly lowered total cholesterol (WMD, -0.19 mmol/L; 95% CI, -0.32 to -0.06; P = 0.004), systolic blood pressure (WMD, -2.26 mmHg; 95% CI, -4.82 to -0.49; P = 0.02), and fasting glucose (WMD, -0.22 mmol/L; 95% CI, -0.42 to -0.03; P = 0.03). Heterogeneity was noted for these outcomes (35.6%, 38.7% and 71.4%, respectively). Our subgroup analysis showed significant reductions in total cholesterol, systolic blood pressure, diastolic blood pressure, glucose, and insulin in subjects ingesting higher dose of resveratrol (≥300 mg/day).
  
  
  
  Our finding provides evidence that daily resveratrol consumption might be a candidate as an adjunct to pharmacological management to better prevent and control cardiovascular disease in overweight/obese individuals.
authors.affiliation: Department of Clinical Pharmacy, Department of Scientific Research and Education, Dongguan Third People's Hospital, Affiliated Dongguan Shilong People's Hospital of Southern Medical University, Dongguan, Guangdong, China.
authors.forename: Haohai
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Pharmacy, Guangdong Province Agricultural Reclamation Central Hospital, Zhanjiang, Guangdong, China.
authors.forename: Guangzhao
authors.initials: G
authors.lastname: Chen
authors.affiliation: Department of Gynaecology and Obstetrics, Dongguan Maternal and Child Health Hospital, Dongguan, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Liao
authors.affiliation: Department of Clinical Pharmacy, Department of Scientific Research and Education, Dongguan Third People's Hospital, Affiliated Dongguan Shilong People's Hospital of Southern Medical University, Dongguan, Guangdong, China.
authors.forename: Yongkun
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Clinical Laboratory, Dongguan Third People's Hospital, Affiliated Dongguan Shilong People's Hospital of Southern Medical University, Dongguan, Guangdong, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Pu
authors.affiliation: Department of Clinical Pharmacy, Department of Scientific Research and Education, Dongguan Third People's Hospital, Affiliated Dongguan Shilong People's Hospital of Southern Medical University, Dongguan, Guangdong, China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Xue
mesh_terms: D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000188:drug therapy*; D002784:Cholesterol / Q000097:blood; D006801:Humans; D007333:Insulin Resistance; D015201:Meta-Analysis as Topic; D009765:Obesity / Q000188:drug therapy*; D050177:Overweight / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic; D015203:Reproducibility of Results; D000077185:Resveratrol; D012307:Risk Factors; D013267:Stilbenes / Q000008:administration & dosage* / Q000097:blood
chemical_list: D015415:Biomarkers; D013267:Stilbenes; D002784:Cholesterol; D000077185:Resveratrol
keywords: Cardiovascular risk factors; obesity; overweight; resveratrol