title: AEG-1/MTDH/LYRIC: A Promiscuous Protein Partner Critical in Cancer, Obesity, and CNS Diseases.
abstract: Since its original discovery in 2002, AEG-1/MTDH/LYRIC has emerged as a primary regulator of several diseases including cancer, inflammatory diseases, and neurodegenerative diseases. AEG-1/MTDH/LYRIC has emerged as a key contributory molecule in almost every aspect of cancer progression, including uncontrolled cell growth, evasion of apoptosis, increased cell migration and invasion, angiogenesis, chemoresistance, and metastasis. Additionally, recent studies highlight a seminal role of AEG-1/MTDH/LYRIC in neurodegenerative diseases and obesity. By interacting with multiple protein partners, AEG-1/MTDH/LYRIC plays multifaceted roles in the pathogenesis of a wide variety of diseases. This review discusses the current state of understanding of AEG-1/MTDH/LYRIC regulation and function in cancer and other diseases with a focus on its association/interaction with several pivotal protein partners.
authors.affiliation: Virginia Commonwealth University, School of Medicine, Richmond, VA, United States; VCU Massey Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA, United States; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA, United States. Electronic address: luni.emdad@vcuhealth.org.
authors.forename: L
authors.initials: L
authors.lastname: Emdad
authors.affiliation: Virginia Commonwealth University, School of Medicine, Richmond, VA, United States; VCU Massey Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA, United States; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA, United States.
authors.forename: S K
authors.initials: SK
authors.lastname: Das
authors.affiliation: Virginia Commonwealth University, School of Medicine, Richmond, VA, United States.
authors.forename: B
authors.initials: B
authors.lastname: Hu
authors.affiliation: Virginia Commonwealth University, School of Medicine, Richmond, VA, United States.
authors.forename: T
authors.initials: T
authors.lastname: Kegelman
authors.affiliation: Ilsong Institute of Life Science, Hallym University, Anyang, Republic of Korea.
authors.forename: D-C
authors.initials: DC
authors.lastname: Kang
authors.affiliation: Cancer Preventive Material Development Research Center, Institute of Korean Medicine, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: S-G
authors.initials: SG
authors.lastname: Lee
authors.affiliation: Virginia Commonwealth University, School of Medicine, Richmond, VA, United States; VCU Massey Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA, United States; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA, United States.
authors.forename: D
authors.initials: D
authors.lastname: Sarkar
authors.affiliation: Virginia Commonwealth University, School of Medicine, Richmond, VA, United States; VCU Massey Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA, United States; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA, United States. Electronic address: paul.fisher@vcuhealth.org.
authors.forename: P B
authors.initials: PB
authors.lastname: Fisher
mesh_terms: D015815:Cell Adhesion Molecules / Q000378:metabolism*; D002493:Central Nervous System Diseases / Q000503:physiopathology*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008565:Membrane Proteins; D009369:Neoplasms / Q000503:physiopathology*; D009765:Obesity / Q000503:physiopathology*; D016601:RNA-Binding Proteins
chemical_list: D015815:Cell Adhesion Molecules; C483039:MTDH protein, human; D008565:Membrane Proteins; D016601:RNA-Binding Proteins
keywords: AEG-1/MTDH/LYRIC; CNS diseases; Cancer aggressiveness; Interacting proteins; Obesity