title: Longitudinal associations between bone and adipose tissue biochemical markers with bone mineralization in boys during puberty.
abstract: We investigated longitudinal relationships between the biochemical markers of bone and adipose tissue with bone mineral content (BMC), bone mineral density (BMD), moderate-to-vigorous physical activity (MVPA) and sedentary time (SED) in pubertal boys.
  
  
  
  Ninety-six boys (11.9 ± 0.6 years old) were measured at baseline, after 12 and 24 months. Body composition (fat mass [FM], lean body mass [LBM]), and whole body (WB), lumbar spine (LS) and femoral neck (FN) BMD and BMC were assessed. Additionally, serum leptin, adiponectin, osteocalcin (OC) and C-terminal telopeptide of type I collagen (CTX) were measured.
  
  
  
  OC had a strong longitudinal inverse effect on changes in WB_BMD (p < 0.001) and LS_BMD (p = 0.021), while CTX had an inverse effect only on changes in FN_BMD (p = 0.011). Leptin had an inverse effect on changes in WB_BMC/WB_BMD (p = 0.001), FN_BMD (p = 0.002) and LS_BMD (p = 0.001). MVPA showed a longitudinal inverse effect on changes in leptin (p = 0.030), however no longitudinal effect of SED to biochemical markers of bone and adipose tissue was found.
  
  
  
  Bone metabolism markers have negative effect on bone mineral accrual during puberty. Increases in MVPA affect leptin, suggesting a positive link of MVPA through leptin metabolism on increases in bone mineralization during puberty.
authors.affiliation: Institute of Sport Sciences and Physiotherapy, Centre of Behavioural, Social and Health Science, Faculty of Medicine, University of Tartu, Tartu, Estonia.
authors.forename: Donvina
authors.initials: D
authors.lastname: Vaitkeviciute
authors.affiliation: Institute of Sport Sciences and Physiotherapy, Centre of Behavioural, Social and Health Science, Faculty of Medicine, University of Tartu, Tartu, Estonia.
authors.forename: Evelin
authors.initials: E
authors.lastname: Lätt
authors.affiliation: Institute of Sport Sciences and Physiotherapy, Centre of Behavioural, Social and Health Science, Faculty of Medicine, University of Tartu, Tartu, Estonia.
authors.forename: Jarek
authors.initials: J
authors.lastname: Mäestu
authors.affiliation: Institute of Sport Sciences and Physiotherapy, Centre of Behavioural, Social and Health Science, Faculty of Medicine, University of Tartu, Tartu, Estonia.
authors.forename: Toivo
authors.initials: T
authors.lastname: Jürimäe
authors.affiliation: Institute of Sport Sciences and Physiotherapy, Centre of Behavioural, Social and Health Science, Faculty of Medicine, University of Tartu, Tartu, Estonia.
authors.forename: Meeli
authors.initials: M
authors.lastname: Saar
authors.affiliation: Institute of Sport Sciences and Physiotherapy, Centre of Behavioural, Social and Health Science, Faculty of Medicine, University of Tartu, Tartu, Estonia.
authors.forename: Priit
authors.initials: P
authors.lastname: Purge
authors.affiliation: Institute of Clinical Medicine, Faculty of Medicine, University of Tartu, Tartu, Estonia.
authors.forename: Katre
authors.initials: K
authors.lastname: Maasalu
authors.affiliation: Institute of Sport Sciences and Physiotherapy, Centre of Behavioural, Social and Health Science, Faculty of Medicine, University of Tartu, Tartu, Estonia. jaak.jurimae@ut.ee.|Institute of Sport Pedagogy and Coaching Sciences, Centre of Behavioral, Social and Health Sciences, University of Tartu, 5 Jakobi Street, 51014, Tartu, Estonia. jaak.jurimae@ut.ee.
authors.forename: Jaak
authors.initials: J
authors.lastname: Jürimäe
mesh_terms: D052242:Adiponectin / Q000097:blood; D050154:Adiposity / Q000502:physiology*; D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D015519:Bone Density / Q000502:physiology*; D016723:Bone Remodeling / Q000502:physiology*; D002648:Child; D024042:Collagen Type I / Q000097:blood; D015444:Exercise / Q000502:physiology*; D006801:Humans; D020738:Leptin / Q000097:blood; D008137:Longitudinal Studies; D008297:Male; D015233:Models, Statistical; D015675:Osteocalcin / Q000097:blood; D010455:Peptides / Q000097:blood; D011627:Puberty / Q000097:blood / Q000502:physiology*; D057185:Sedentary Behavior
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D024042:Collagen Type I; D020738:Leptin; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin
keywords: Adipokines; Bone turnover; Longitudinal analysis; Physical activity; Pubertal boys