title: [Novel biomarkers for latent tuberculosis infection by plasma proteomic profiling].
abstract: OBJECTIVE
  To screen specific biomarkers for latent tuberculosis infection by comparing the plasma proteomic profiling between latent tuberculosis infection and healthy controls.
  
  
  METHODS
  The plasma proteins from 15 cases with latent tuberculosis infection and 15 healthy controls were detected by the label-free quantitative proteomic technology. Differential expressed proteins were analyzed by GO, KEGG, and BiNGO analysis. Student's t test was used to analyze the differential expression between 2 groups.
  
  
  RESULTS
  Twenty-three candidate proteins were identified, among which 15 proteins were downregulated (<0.5-fold at P<0.05) and 8 proteins were upregulated (>2.0-fold at P<0.05) in the latent tuberculosis infection group. Bioinformatic analysis revealed 3 proteins AAT, C3 and C4A to be the most significant.
  
  
  CONCLUSIONS
  There were differential plasma protein profiles between latent tuberculosis infection and healthy controls. Candidate proteins AAT, C3 and C4A were promising biomarkers for discriminating cases with latent tuberculosis infection from healthy persons.
authors.affiliation: Beijing Chest Hospital, Capital Medical University; Beijing Tuberculosis and Thoracic Tumor Research Institute; Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing 101149, China.
authors.forename: H S
authors.initials: HS
authors.lastname: Sun
authors.forename: L P
authors.initials: LP
authors.lastname: Pan
authors.forename: H Y
authors.initials: HY
authors.lastname: Jia
authors.forename: F J
authors.initials: FJ
authors.lastname: Du
authors.forename: L H
authors.initials: LH
authors.lastname: Zheng
authors.forename: Q Y
authors.initials: QY
authors.lastname: Liu
authors.forename: Z D
authors.initials: ZD
authors.lastname: Zhang
mesh_terms: D015415:Biomarkers / Q000097:blood*; D001798:Blood Proteins / Q000032:analysis*; D016022:Case-Control Studies; D019295:Computational Biology; D006801:Humans; D055985:Latent Tuberculosis / Q000097:blood* / Q000175:diagnosis; D020543:Proteome / Q000032:analysis*
chemical_list: D015415:Biomarkers; D001798:Blood Proteins; D020543:Proteome