title: High-affinity host-guest chemistry of large-ring cyclodextrins.
abstract: The host-guest chemistry of large-ring cyclodextrins (LRCDs) has been largely unexplored due to the lack of suitable guest molecules that bind with significant affinities to enable potential applications. Herein, we report their complexation with dodecaborate anions (B12X12(2-)), a novel class of guest molecules. The binding constants of the inorganic guests (10(4)-10(6) M(-1)) allow their classification as the first tight binders for LRCDs.
authors.affiliation: Department of Life Sciences and Chemistry, Jacobs University Bremen, Campus Ring 1, 28759 Bremen, Germany. k.assaf@jacobs-university.de w.nau@jacobs-university.de.
authors.forename: Khaleel I
authors.initials: KI
authors.lastname: Assaf
authors.affiliation: Department of Life Sciences and Chemistry, Jacobs University Bremen, Campus Ring 1, 28759 Bremen, Germany. k.assaf@jacobs-university.de w.nau@jacobs-university.de.
authors.forename: Detlef
authors.initials: D
authors.lastname: Gabel
authors.affiliation: Department of Microbiology and Bioprocess Technology, Institute of Biochemistry, Leipzig University, Johannisallee 21-23, 04103 Leipzig, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Zimmermann
authors.affiliation: Department of Life Sciences and Chemistry, Jacobs University Bremen, Campus Ring 1, 28759 Bremen, Germany. k.assaf@jacobs-university.de w.nau@jacobs-university.de.
authors.forename: Werner M
authors.initials: WM
authors.lastname: Nau
mesh_terms: D000838:Anions / Q000737:chemistry; D001896:Boron Compounds / Q000737:chemistry*; D003505:Cyclodextrins / Q000737:chemistry*
chemical_list: D000838:Anions; D001896:Boron Compounds; D003505:Cyclodextrins; C119788:dodecaborate