title: The Multifaceted Roles of HY5 in Plant Growth and Development.
abstract: ELONGATED HYPOCOTYL5 (HY5), a member of the bZIP transcription factor family, inhibits hypocotyl growth and lateral root development, and promotes pigment accumulation in a light-dependent manner in Arabidopsis. Recent research on its role in different processes such as hormone, nutrient, abiotic stress (abscisic acid, salt, cold), and reactive oxygen species signaling pathways clearly places HY5 at the center of a transcriptional network hub. HY5 regulates the transcription of a large number of genes by directly binding to cis-regulatory elements. Recently, HY5 has also been shown to activate its own expression under both visible and UV-B light. Moreover, HY5 acts as a signal that moves from shoot to root to promote nitrate uptake and root growth. Here, we review recent advances on HY5 research in diverse aspects of plant development and highlight still open questions that need to be addressed in the near future for a complete understanding of its function in plant signaling and beyond.
authors.affiliation: Department of Biological and Environmental Sciences, Gothenburg University, Gothenburg 40530, Sweden. Electronic address: ngsreeram@gmail.com.
authors.forename: Sreeramaiah N
authors.initials: SN
authors.lastname: Gangappa
authors.affiliation: IFEVA, UBA, CONICET, Facultad de Agronomía, Avenida San Martín 4453, C1417DSE Buenos Aires, Argentina. Electronic address: botto@agro.uba.ar.
authors.forename: Javier F
authors.initials: JF
authors.lastname: Botto
mesh_terms: D000040:Abscisic Acid; D017360:Arabidopsis / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D029681:Arabidopsis Proteins / Q000187:drug effects / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology / Q000528:radiation effects; D050976:Basic-Leucine Zipper Transcription Factors / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology; D003080:Cold Temperature; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects / Q000528:radiation effects; D018506:Gene Expression Regulation, Plant; D008027:Light; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects / Q000528:radiation effects
chemical_list: D029681:Arabidopsis Proteins; D050976:Basic-Leucine Zipper Transcription Factors; C109254:HY5 protein, Arabidopsis; D009687:Nuclear Proteins; D000040:Abscisic Acid
keywords: HY5; HY5-orthologs; growth and development; hormonal cross-talk; photomorphogenesis; transcriptional regulation