title: Epididymal Cystadenomas in von Hippel-Lindau Disease Showing Increased Activity on 68Ga DOTATATE PET/CT.
abstract: von Hippel-Lindau (VHL) disease is a familial cancer syndrome characterized by the development of a variety of malignant and benign tumors, including epididymal cystadenomas. We report a case of a VHL patient with bilateral epididymal cystadenomas who was evaluated with Ga DOTATATE PET/CT, showing intensely increased activity (SUVmax, 21.6) associated with the epididymal cystadenomas, indicating cell-surface overexpression of somatostatin receptors. The presented case supports the usefulness of somatostatin receptor imaging using Ga DOTA-conjugated peptides for detection and follow-up of VHL manifestations, as well as surveillance of asymptomatic gene carriers.
authors.affiliation: From the *Radiology and Imaging Sciences, Warren Grant Magnuson Clinical Center, †Division of Nuclear Medicine, RADIS, Clinical Center, and ‡Endocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD; §Endocrine and Thoracic Surgery, University Hospitals of Geneva, Geneva, Switzerland; and ∥Center for Research in Computer Vision, Electrical and Computer Science Department, University of Central Florida, Orlando, FL.
authors.forename: Georgios Z
authors.initials: GZ
authors.lastname: Papadakis
authors.forename: Corina
authors.initials: C
authors.lastname: Millo
authors.forename: Samira M
authors.initials: SM
authors.lastname: Sadowski
authors.forename: Ulas
authors.initials: U
authors.lastname: Bagci
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Patronas
mesh_terms: D003537:Cystadenoma / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D000072078:Positron Emission Tomography Computed Tomography; D019275:Radiopharmaceuticals; D013088:Spermatocele / Q000000981:diagnostic imaging*; D006623:von Hippel-Lindau Disease / Q000000981:diagnostic imaging*
chemical_list: D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; C513399:gallium Ga 68 dotatate