title: Prevalence and characteristics of acid gastro-oesophageal reflux disease in Jackhammer oesophagus.
abstract: BACKGROUND
  An association between acid gastro-oesophageal reflux disease (GERD) and Jackhammer oesophagus has been suggested.
  
  
  OBJECTIVE
  To assess the prevalence and characteristics of acid-GERD in Jackhammer oesophagus and the efficacy of proton pump inhibitors.
  
  
  METHODS
  Data and outcomes of patients with Jackhammer oesophagus were assessed. Two groups were compared: (i) GERD, defined by endoscopic oesophagitis or by an increase in acid exposure time or by an acid-hypersensitive oesophagus and (ii) non-GERD defined by normal oesophageal acid exposure without acid-hypersensitive oesophagus.
  
  
  RESULTS
  Among the 1994 high-resolution manometries performed, 44 Jackhammer oesophagus (2.2%) were included (sex ratio M/F: 19/25; median age: 66 [61-75] years). Nineteen patients (43.2%) had GERD, 16 (36.4%) had no GERD and 9 patients (20.4%) were undetermined. Dysphagia was the predominant symptom (37/43 (86%)). After a median follow-up of 25.3 months [9.6-31.4], dysphagia was improved in 22/36 (61.1%) patients. Dysphagia improvement as well as other symptoms improvement was not associated with GERD status or proton-pump inhibitors use.
  
  
  CONCLUSIONS
  The prevalence of GERD is high among patients with Jackhammer oesophagus. The rates of symptom improvement in Jackhammer oesophagus were high regardless of the use of proton-pump inhibitors treatment or of the presence of GERD.
authors.affiliation: Gastroenterology Unit, CHRU Pontchaillou, University of Rennes 1, Rennes, France.
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Mallet
authors.affiliation: Digestive Disease Unit, CHRU Pontchaillou, University of Rennes 1, Rennes, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Ropert
authors.affiliation: Gastroenterology Unit, CHRU Pontchaillou, University of Rennes 1, Rennes, France; INSERM U991, University of Rennes 1, Rennes, France; CIC 1414, INPHY, University of de Rennes 1, Rennes, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Bouguen
authors.affiliation: Gastroenterology Unit, CHRU Pontchaillou, University of Rennes 1, Rennes, France; INSERM U991, University of Rennes 1, Rennes, France; CIC 1414, INPHY, University of de Rennes 1, Rennes, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Siproudhis
authors.affiliation: Gastroenterology Unit, CH Yves le Foll, Saint-Brieuc, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Boutroux
authors.affiliation: Gastroenterology Unit, CHRU Pontchaillou, University of Rennes 1, Rennes, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Bretagne
authors.affiliation: Gastroenterology Unit, CHRU Pontchaillou, University of Rennes 1, Rennes, France; Digestive Disease Unit, CHRU Pontchaillou, University of Rennes 1, Rennes, France; INSERM U991, University of Rennes 1, Rennes, France; CIC 1414, INPHY, University of de Rennes 1, Rennes, France. Electronic address: charlene.brochard@chu-rennes.fr.
authors.forename: Charlène
authors.initials: C
authors.lastname: Brochard
mesh_terms: D000368:Aged; D002637:Chest Pain / Q000209:etiology; D003680:Deglutition Disorders / Q000209:etiology; D016099:Endoscopy, Gastrointestinal; D015154:Esophageal Motility Disorders / Q000503:physiopathology*; D005260:Female; D005764:Gastroesophageal Reflux / Q000175:diagnosis* / Q000188:drug therapy* / Q000453:epidemiology*; D006356:Heartburn / Q000209:etiology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008365:Manometry; D008875:Middle Aged; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D054328:Proton Pump Inhibitors
keywords: Gastroesophageal reflux disease; Jackhammer oesophagus; Proton pump inhibitor