title: Serial Frequencies and Clinical Features of Uveitis in Hokkaido, Japan.
abstract: OBJECTIVE
  Environmental and lifestyle changes influence the clinical features of uveitis. This study reviewed the epidemiologic trends of uveitis in the Japanese population.
  
  
  METHODS
  A retrospective review of the past 80 years of reports from Hokkaido University Hospital.
  
  
  RESULTS
  In the 1930s, tuberculosis accounted for 46% and syphilitic uveitis for 31% of cases. The frequency of these diseases decreased to 12% in the 1950s; 8% in 1969; 0.6% in the 1990s; and 0.8% in the 2000s, while the rate of non-infectious uveitis increased. The three most common specific diagnoses were: sarcoidosis, Vogt-Koyanagi-Harada disease, and Behçet disease. Although Behçet disease was the most frequent non-infectious uveitis until the 1980s, sarcoidosis is now the most frequent cause of newly diagnosed non-infectious uveitis.
  
  
  CONCLUSIONS
  The etiology of uveitis has changed with the times. Tubercular and syphilitic cases have greatly decreased, and sarcoidosis is the most frequent type of uveitis today.
authors.affiliation: a Department of Ophthalmology , Hokkaido University Graduate School of Medicine , Sapporo , Japan.
authors.forename: Daiju
authors.initials: D
authors.lastname: Iwata
authors.affiliation: a Department of Ophthalmology , Hokkaido University Graduate School of Medicine , Sapporo , Japan.
authors.forename: Kazuomi
authors.initials: K
authors.lastname: Mizuuchi
authors.affiliation: a Department of Ophthalmology , Hokkaido University Graduate School of Medicine , Sapporo , Japan.
authors.forename: Koki
authors.initials: K
authors.lastname: Aoki
authors.affiliation: b Department of Ophthalmology , Health Sciences University of Hokkaido , Sapporo , Japan.
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Horie
authors.affiliation: a Department of Ophthalmology , Hokkaido University Graduate School of Medicine , Sapporo , Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Kase
authors.affiliation: a Department of Ophthalmology , Hokkaido University Graduate School of Medicine , Sapporo , Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Namba
authors.affiliation: a Department of Ophthalmology , Hokkaido University Graduate School of Medicine , Sapporo , Japan.
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Ohno
authors.affiliation: a Department of Ophthalmology , Hokkaido University Graduate School of Medicine , Sapporo , Japan.
authors.forename: Susumu
authors.initials: S
authors.lastname: Ishida
authors.affiliation: a Department of Ophthalmology , Hokkaido University Graduate School of Medicine , Sapporo , Japan.|b Department of Ophthalmology , Health Sciences University of Hokkaido , Sapporo , Japan.
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Kitaichi
mesh_terms: D000328:Adult; D044466:Asian People / Q000208:ethnology; D005260:Female; D006785:Hospitals, University / Q000706:statistics & numerical data; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D012189:Retrospective Studies; D013587:Syphilis / Q000208:ethnology; D014392:Tuberculosis, Ocular / Q000208:ethnology; D014605:Uveitis / Q000175:diagnosis* / Q000208:ethnology*
keywords: Behçet disease; etiology; sarcoidosis; syphilis; tuberculosis