title: [Pathological Complete Response of Advanced Gastric Cancer after Docetaxel and S-1 Combination Neoadjuvant Chemotherapy-A Case Report].
abstract: A 70-year-old man with left abdominal pain was referred to our hospital, and was diagnosed with type 1 advanced gastric cancer with lymph node metastasis. Neoadjuvant chemotherapy(NAC)with docetaxel and S-1 combination was administered. After 2 courses of chemotherapy, total gastrectomy with D2 lymph node dissection, splenectomy, and cholecystectomy were performed. Pathologically, viable cancer cells were not evident in the primary lesion and lymph nodes. The pathological response of NAC was judged to be Grade 3. On immunohistochemical analysis of the biopsy specimens obtained before treatment, the cancer cells were positive for class III b-tubulin and negative for TS, DPD, and ERCC1. The anti-tumor effect of S-1 may have led to the pCR.
authors.affiliation: Dept. of Gastroenterological Surgery, Yokohama City University.
authors.forename: Sayaka
authors.initials: S
authors.lastname: Arisaka
authors.forename: Ryuji
authors.initials: R
authors.lastname: Kosaka
authors.forename: Chikara
authors.initials: C
authors.lastname: Kunisaki
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ichikawa
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Akiyama
authors.forename: Mitsuko
authors.initials: M
authors.lastname: Furuya
authors.forename: Kenichi
authors.initials: K
authors.lastname: Ohashi
authors.forename: Itaru
authors.initials: I
authors.lastname: Endo
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001706:Biopsy; D000077143:Docetaxel; D004338:Drug Combinations; D006801:Humans; D008297:Male; D020360:Neoadjuvant Therapy; D010094:Oxonic Acid / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D043823:Taxoids / Q000008:administration & dosage; D005641:Tegafur / Q000008:administration & dosage
chemical_list: D004338:Drug Combinations; D043823:Taxoids; C079198:S 1 (combination); D005641:Tegafur; D000077143:Docetaxel; D010094:Oxonic Acid