title: Chamigrane Sesquiterpenes from a Basidiomycetous Endophytic Fungus XG8D Associated with Thai Mangrove Xylocarpus granatum.
abstract: Six new chamigrane sesquiterpenes, merulinols A‒F (1‒6), and four known metabolites (7‒10) were isolated from the culture of the basidiomycetous fungus XG8D, a mangrove-derived endophyte. Their structures were elucidated mainly by 1D and 2D NMR, while the structures of 1 and 2 were further confirmed by single-crystal X-ray diffraction analysis. The in vitro cytotoxicity of all compounds was evaluated against three human cancer cell lines, MCF-7, Hep-G2, and KATO-3. Compounds 3 and 4 selectively displayed cytotoxicity against KATO-3 cells with IC50 values of 35.0 and 25.3 μM, respectively.
authors.affiliation: The United Graduate School of Agricultural Science, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan. csiwattra@hotmail.com.
authors.forename: Siwattra
authors.initials: S
authors.lastname: Choodej
authors.affiliation: Faculty of Science and Technology, Valaya Alongkorn Rajabhat University under Royal Patronage, Pathumtani 13138, Thailand. thapong_sthc@hotmail.com.
authors.forename: Thapong
authors.initials: T
authors.lastname: Teerawatananond
authors.affiliation: The United Graduate School of Agricultural Science, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan. mitunaga@gifu-u.ac.jp.
authors.forename: Tohru
authors.initials: T
authors.lastname: Mitsunaga
authors.affiliation: Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand. Khanitha.P@chula.ac.th.
authors.forename: Khanitha
authors.initials: K
authors.lastname: Pudhom
mesh_terms: D001487:Basidiomycota / Q000737:chemistry*; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray / Q000379:methods; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D060026:Endophytes / Q000737:chemistry*; D005658:Fungi / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D061986:MCF-7 Cells; D015394:Molecular Structure; D043982:Rhizophoraceae / Q000382:microbiology*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology; D013785:Thailand; D014961:X-Ray Diffraction / Q000379:methods
chemical_list: D012717:Sesquiterpenes
keywords: chamigrane; cytotoxic; endophytic fungus; sesquiterpene