title: CX3CL1/CX3CR1 in Alzheimer's Disease: A Target for Neuroprotection.
abstract: CX3C chemokine ligand 1 (CX3CL1) is an intriguing chemokine belonging to the CX3C family. CX3CL1 is secreted by neurons and plays an important role in modulating glial activation in the central nervous system after binding to its sole receptor CX3CR1 which mainly is expressed on microglia. Emerging data highlights the beneficial potential of CX3CL1-CX3CR1 in the pathogenesis of Alzheimer's disease (AD), a common progressive neurodegenerative disease, and in the progression of which neuroinflammation plays a vital role. Even so, the importance of CX3CL1/CX3CR1 in AD is still controversial and needs further clarification. In this review, we make an attempt to present a concise map of CX3CL1-CX3CR1 associated with AD to find biomarkers for early diagnosis or therapeutic interventions.
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
authors.forename: Peiqing
authors.initials: P
authors.lastname: Chen
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
authors.forename: Wenjuan
authors.identifier: 0000-0003-2529-3404
authors.initials: W
authors.lastname: Zhao
authors.affiliation: Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100 Haining Road, Shanghai 200080, China.
authors.forename: Yanjie
authors.initials: Y
authors.lastname: Guo
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Xu
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
authors.forename: Ming
authors.identifier: 0000-0001-6095-1973
authors.initials: M
authors.lastname: Yin
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism*; D000818:Animals; D054428:Chemokine CX3CL1 / Q000378:metabolism*; D006801:Humans; D017628:Microglia / Q000378:metabolism / Q000473:pathology; D009473:Neuronal Plasticity; D000066829:Neuroprotection; D019707:Receptors, Chemokine / Q000378:metabolism*
chemical_list: D054428:Chemokine CX3CL1; D019707:Receptors, Chemokine