title: [Zinc and gastrointestinal disorders].
abstract: Zinc, an essential trace element, affects immune responses, skin metabolism, hormone composition, and some sensory function, so that the deficiency presents various symptoms such as immunodeficiency and taste obstacle. Further, the zinc deficiency also considers as a risk of various diseases. Recent reports demonstrated that -20% of the Japanese population was marginally zinc deficiency, and over 25% of the global population is at high risk of zinc deficiency. In gastrointestinal disorders, zinc plays an important role in the healing of mucosal and epithelial damage. In fact, polaprezinc, a chelate compound of zinc and L-carnosine, has been used for the treatment of gastric ulcer and gastritis. We describe here the therapeutic effect of zinc on gastrointestinal disorders.
authors.forename: Yasuki
authors.initials: Y
authors.lastname: Higashimura
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Takagi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Naito
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D005767:Gastrointestinal Diseases / Q000188:drug therapy*; D051547:Heme Oxygenase-1 / Q000378:metabolism; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects; D008264:Macrophages / Q000378:metabolism; D015032:Zinc / Q000627:therapeutic use*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D051547:Heme Oxygenase-1; D015032:Zinc