title: Prevalence of pyrazinamide resistance across the spectrum of drug resistant phenotypes of Mycobacterium tuberculosis.
abstract: Pyrazinamide resistance is largely unknown in the spectrum of drug resistant phenotypes. We summarize data on PZA resistance in clinical isolates from South Africa. PZA DST should be performed when considering its inclusion in treatment of patients with rifampicin-resistant TB or MDR-TB.
authors.affiliation: SA MRC Centre for Tuberculosis Research, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Stellenbosch University, South Africa.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Whitfield
authors.affiliation: SA MRC Centre for Tuberculosis Research, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Stellenbosch University, South Africa.
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Streicher
authors.affiliation: National Health Laboratory Service, Cape Town, South Africa.
authors.forename: Tania
authors.initials: T
authors.lastname: Dolby
authors.affiliation: National Health Laboratory Service, Cape Town, South Africa.
authors.forename: John A
authors.initials: JA
authors.lastname: Simpson
authors.affiliation: SA MRC Centre for Tuberculosis Research, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Stellenbosch University, South Africa.
authors.forename: Samantha L
authors.initials: SL
authors.lastname: Sampson
authors.affiliation: SA MRC Centre for Tuberculosis Research, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Stellenbosch University, South Africa.
authors.forename: Paul D
authors.initials: PD
authors.lastname: Van Helden
authors.affiliation: University of North Carolina at Chapel Hill, North Carolina, USA; Epidemiology for Global Health Institute, Department of Epidemiology and Social Medicine, Faculty of Medicine, University of Antwerp, Antwerp, Belgium.
authors.forename: Annelies
authors.initials: A
authors.lastname: Van Rie
authors.affiliation: SA MRC Centre for Tuberculosis Research, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Stellenbosch University, South Africa. Electronic address: rw1@sun.ac.za.
authors.forename: Robin M
authors.initials: RM
authors.lastname: Warren
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use*; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D005838:Genotype; D006801:Humans; D008826:Microbial Sensitivity Tests; D009154:Mutation; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000235:genetics / Q000472:pathogenicity; D010641:Phenotype; D015995:Prevalence; D011718:Pyrazinamide / Q000627:therapeutic use*; D013019:South Africa / Q000453:epidemiology; D018088:Tuberculosis, Multidrug-Resistant / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents; D011718:Pyrazinamide
keywords: DNA sequencing; Mycobacterium tuberculosis; Pyrazinamide; pncA gene