title: Autoantibodies to heterogeneous nuclear ribonuclear protein A1 (hnRNPA1) cause altered 'ribostasis' and neurodegeneration; the legacy of HAM/TSP as a model of progressive multiple sclerosis.
abstract: Several years following its discovery in 1980, infection with human T-lymphotropic virus type 1 (HTLV-1) was shown to cause HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), a disease biologically similar to progressive forms of multiple sclerosis (MS). In this manuscript, we review some of the clinical, pathological, and immunological similarities between HAM/TSP and MS with an emphasis on how autoantibodies to an RNA binding protein, heterogeneous nuclear ribonuclear protein A1 (hnRNP A1), might contribute to neurodegeneration in immune mediated diseases of the central nervous system.
authors.affiliation: Veterans Administration Medical Center, Memphis, TN, USA; Department of Neurology, University of Tennessee Health Science Center, Memphis, TN, USA; Department of Anatomy/Neurobiology, University of Tennessee Health Science Center, Memphis, TN, USA; Neuroscience Institute, University of Tennessee Health Science Center, Memphis, TN, USA. Electronic address: mlevin@uthsc.edu.
authors.forename: Michael C
authors.initials: MC
authors.lastname: Levin
authors.affiliation: Veterans Administration Medical Center, Memphis, TN, USA; Department of Neurology, University of Tennessee Health Science Center, Memphis, TN, USA.
authors.forename: Sangmin
authors.initials: S
authors.lastname: Lee
authors.affiliation: Veterans Administration Medical Center, Memphis, TN, USA; Department of Neurology, University of Tennessee Health Science Center, Memphis, TN, USA.
authors.forename: Lidia A
authors.initials: LA
authors.lastname: Gardner
authors.affiliation: Veterans Administration Medical Center, Memphis, TN, USA; Department of Neurology, University of Tennessee Health Science Center, Memphis, TN, USA.
authors.forename: Yoojin
authors.initials: Y
authors.lastname: Shin
authors.affiliation: Veterans Administration Medical Center, Memphis, TN, USA; Department of Neurology, University of Tennessee Health Science Center, Memphis, TN, USA; Department of Anatomy/Neurobiology, University of Tennessee Health Science Center, Memphis, TN, USA; Neuroscience Institute, University of Tennessee Health Science Center, Memphis, TN, USA.
authors.forename: Joshua N
authors.initials: JN
authors.lastname: Douglas
authors.affiliation: Veterans Administration Medical Center, Memphis, TN, USA; Department of Neurology, University of Tennessee Health Science Center, Memphis, TN, USA; Department of Anatomy/Neurobiology, University of Tennessee Health Science Center, Memphis, TN, USA; Neuroscience Institute, University of Tennessee Health Science Center, Memphis, TN, USA.
authors.forename: Hannah
authors.initials: H
authors.lastname: Salapa
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D000076245:Heterogeneous Nuclear Ribonucleoprotein A1; D034481:Heterogeneous-Nuclear Ribonucleoprotein Group A-B / Q000276:immunology*; D006801:Humans; D020528:Multiple Sclerosis, Chronic Progressive / Q000276:immunology* / Q000473:pathology; D019636:Neurodegenerative Diseases / Q000276:immunology / Q000473:pathology; D015493:Paraparesis, Tropical Spastic / Q000276:immunology* / Q000473:pathology
chemical_list: D001323:Autoantibodies; D000076245:Heterogeneous Nuclear Ribonucleoprotein A1; D034481:Heterogeneous-Nuclear Ribonucleoprotein Group A-B; C000619656:hnRNPA1 protein, human
keywords: Autoimmunity; HTLV-1; Multiple sclerosis; Neurodegeneration; RNA; RNA binding protein