title: Evidences of Herbal Medicine-Derived Natural Products Effects in Inflammatory Lung Diseases.
abstract: Pulmonary inflammation is a hallmark of many respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), and acute respiratory syndrome distress (ARDS). Most of these diseases are treated with anti-inflammatory therapy in order to prevent or to reduce the pulmonary inflammation. Herbal medicine-derived natural products have been used in folk medicine and scientific studies to evaluate the value of these compounds have grown in recent years. Many substances derived from plants have the biological effects in vitro and in vivo, such as flavonoids, alkaloids, and terpenoids. Among the biological activities of natural products derived from plants can be pointed out the anti-inflammatory, antiviral, antiplatelet, antitumor anti-allergic activities, and antioxidant. Although many reports have evaluated the effects of these compounds in experimental models, studies evaluating clinical trials are scarce in the literature. This review aims to emphasize the effects of these different natural products in pulmonary diseases in experimental models and in humans and pointing out some possible mechanisms of action.
authors.affiliation: Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Federal University of São Paulo, Diadema-SP 09972-270, Brazil.
authors.forename: Fernanda Paula R
authors.identifier: 0000-0001-5837-4310
authors.initials: FP
authors.lastname: Santana
authors.affiliation: School of Medicine, University of São Paulo, São Paulo-SP 01246903, Brazil.
authors.forename: Nathalia M
authors.identifier: 0000-0002-5340-5007
authors.initials: NM
authors.lastname: Pinheiro
authors.affiliation: Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Federal University of São Paulo, Diadema-SP 09972-270, Brazil.
authors.forename: Márcia Isabel B
authors.initials: MI
authors.lastname: Mernak
authors.affiliation: School of Medicine, University of São Paulo, São Paulo-SP 01246903, Brazil.
authors.forename: Renato F
authors.identifier: 0000-0001-6234-1458
authors.initials: RF
authors.lastname: Righetti
authors.affiliation: School of Medicine, University of São Paulo, São Paulo-SP 01246903, Brazil.
authors.forename: Mílton A
authors.initials: MA
authors.lastname: Martins
authors.affiliation: Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Federal University of São Paulo, Diadema-SP 09972-270, Brazil.
authors.forename: João H G
authors.initials: JH
authors.lastname: Lago
authors.affiliation: School of Medicine, University of São Paulo, São Paulo-SP 01246903, Brazil.
authors.forename: Fernanda D T Q Dos Santos
authors.identifier: 0000-0002-6402-3055
authors.initials: FD
authors.lastname: Lopes
authors.affiliation: School of Medicine, University of São Paulo, São Paulo-SP 01246903, Brazil.
authors.forename: Iolanda F L C
authors.initials: IF
authors.lastname: Tibério
authors.affiliation: Instituto de Saúde e Sociedade, Federal University of São Paulo, Santos-SP 11015-020, Brazil.
authors.forename: Carla M
authors.identifier: 0000-0003-1160-0442
authors.initials: CM
authors.lastname: Prado
mesh_terms: D000818:Animals; D001688:Biological Products / Q000627:therapeutic use*; D029001:Herbal Medicine / Q000379:methods*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000276:immunology; D008171:Lung Diseases / Q000188:drug therapy* / Q000276:immunology
chemical_list: D001688:Biological Products