title: Case of a miniature dachshund with a primitive neuroectodermal tumor confined to the forebrain region treated with a combination of surgery and chemotherapy.
abstract: A miniature dachshund aged 9 years and 7 months with a history of polyuria/polydipsia and depression was referred. General physical and neurological examinations revealed no obvious abnormalities. MRI of the brain revealed a large space-occupying lesion in the left frontal lobe. This was surgically removed and pathologically diagnosed as a primitive neuroectodermal tumor (PNET). Although the clinical signs had been improved, follow-up MRI revealed recurrence of the tumor. Lomustine was administered, but 1 year after surgery, the dog exhibited cluster seizures and died. This is the first reported case of a dog with PNET confined to the forebrain region treated by surgical resection in combination with chemotherapy, as observed by repeated follow-up MRI.
authors.affiliation: Kyoto Animal Referral Medical Center, 208-4, Shinarami, Tai, Kumiyama-cho, Kuze-gun, Kyoto 613-0036, Japan.
authors.forename: Yuya
authors.initials: Y
authors.lastname: Nakamoto
authors.forename: Akihiko
authors.initials: A
authors.lastname: Yamada
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Uchida
authors.forename: Satoru
authors.initials: S
authors.lastname: Matsunaga
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Ozawa
mesh_terms: D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D003131:Combined Modality Therapy / Q000662:veterinary; D004283:Dog Diseases / Q000188:drug therapy* / Q000601:surgery*; D004285:Dogs; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D008130:Lomustine / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging / Q000662:veterinary; D009364:Neoplasm Recurrence, Local / Q000662:veterinary; D018242:Neuroectodermal Tumors, Primitive / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*
chemical_list: D018906:Antineoplastic Agents, Alkylating; D008130:Lomustine